Neutron spectrum determination of d(20)+Be source reaction by the dosimetry foils method

Science.gov (United States)

Stefanik, Milan; Bem, Pavel; Majerle, Mitja; Novak, Jan; Simeckova, Eva

2017-11-01

The cyclotron-based fast neutron generator with the thick beryllium target operated at the NPI Rez Fast Neutron Facility is primarily designed for the fast neutron production in the p+Be source reaction at 35 MeV. Besides the proton beam, the isochronous cyclotron U-120M at the NPI provides the deuterons in the energy range of 10-20 MeV. The experiments for neutron field investigation from the deuteron bombardment of thick beryllium target at 20 MeV were performed just recently. For the neutron spectrum measurement of the d(20)+Be source reaction, the dosimetry foils activation method was utilized. Neutron spectrum reconstruction from resulting reaction rates was performed using the SAND-II unfolding code and neutron cross-sections from the EAF-2010 nuclear data library. Obtained high-flux white neutron field from the d(20)+Be source is useful for the intensive irradiation experiments and cross-section data validation.

Light ions cyclotron bombardment to simulate fast neutron radiation damage in nuclear materials

International Nuclear Information System (INIS)

Segura, E.; Lucki, G.; Aguiar, D.

1984-01-01

The applicability and limitations of the use of cyclotron light ions bombardment to simulate the effects of the neutron irradiation are presented. Light ions with energies of about 10 MeV are capable to produce homogeneous damage in specimens suitable for measuring bulk mechanical properties although their low damage rate of 10 -5 dpa.sec -1 limit the dose range to a few dpa. On the other hand, cyclotron alpha particle implantation provides a fast and convenient way of introducing helium with a minimum of side effects so that we can take advantage of this technique to get better understanding of the mechanism by which this insoluble gas produces high temperature embrittlement. Some experimental details such as dimensions and cooling techniques are described. Finally a description of the infrastructure for cyclotron alpha particle implantation and a creep-test facility of the Division of Radiation Damage at IPEN-CNEN/SP are presented. (Author) [pt

Role of neuropeptide Y (NPY) in the regulation of reproduction: study based on catfish model.

Science.gov (United States)

Subhedar, Nishikant; Gaikwad, Archana; Biju, K C; Saha, Subhash

2005-04-01

Significance of NPY in the regulation of GnRH-LH axis was evaluated. Considerable NPY immunoreactivity was seen in the components like olfactory system, basal telencephalon, preoptic and tuberal areas, and the pituitary gland that serve as neuroanatomical substrates for processing reproductive information. Close anatomical association as well as colocalizations of NPY and GnRH were seen in the olfactory receptor neurons, olfactory nerve fibers and their terminals in the glomeruli, ganglion cells of nervus terminalis, medial olfactory tracts, fibers in the ventral telencephalon and pituitary. In the pituitary, NPY fibers seem to innervate the GnRH as well as LH cells. Intracranial administration of NPY resulted in significant increase in the GnRH immunoreactivity in all the components of the olfactory system. In the pituitary, NPY augmented the population of GnRH fibers and LH cells. HPLC analysis showed that salmon GnRH content in the olfactory organ, bulb, preoptic area+telencephalon and pituitary was also significantly increased following NPY treatment. NPY may play a role in positive regulation of GnRH throughout the neuraxis and also up-regulate the LH cells in the pituitary.

Status Report on Cyclotron Operation

International Nuclear Information System (INIS)

Kovacs, P.; Szuecs, I.; Ander, I.; Lakatos, T.; Tarkanyi, F.

2004-01-01

Complete text of publication follows. The operation of the cyclotron in 2004 was concentrated to the usual 9 months; January, July and August were reserved for maintenance and holidays. The overall working time of the accelerator was 3554 hours, the time used for systematic maintenance was 450 hours. The breakdown periods amounted to 70 hours last year, included in it a 50 hours repair of RF control module under guarantee. The cyclotron was available for users during 3034 hours. The effectively used beam-on-target time statistics is summarized in Table 1. Developments: A new measuring site with a HPGe detector based gamma spectrometer is under installation in the basement of the Cyclotron Laboratory. A two channel pneumatic rabbit system is also under development to enable fast transport of samples between the new measuring site and two irradiation sites (the low intensity fast neutron irradiation site and the beam line used for Thin Layer Activation). (author)

NPY/AgRP neurons are not essential for feeding responses to glucoprivation.

Science.gov (United States)

Luquet, Serge; Phillips, Colin T; Palmiter, Richard D

2007-02-01

Animals respond to hypoglycemia by eating and by stimulating gluconeogenesis. These responses to glucose deprivation are initiated by glucose-sensing neurons in the brain, but the neural circuits that control feeding behavior are not well established. Neurons in the arcuate region of the hypothalamus that express neuropeptide Y (NPY) and agouti-related protein (AgRP) have been implicated in mediating the feeding response to glucoprivation. We devised a method to selectively ablate these neurons in neonatal mice and then tested adult mice for their feeding responses to fasting, mild hypoglycemia, 2-deoxy-d-glucose and a ghrelin receptor agonist. Whereas the feeding response to the ghrelin receptor agonist was completely abrogated, the feeding response to glucoprivation was normal. The feeding response after a fast was attenuated when standard chow was available but normal with more palatable solid or liquid diet. We conclude that NPY/AgRP neurons are not necessary for generating or mediating the orexigenic response to glucose deficiency, but they are essential for the feeding response to ghrelin and refeeding on standard chow after a fast.

Current drive with fast waves, electron cyclotron waves, and neutral injection in the DIII-D tokamak

International Nuclear Information System (INIS)

Prater, R.; Petty, C.C.; Pinsker, R.I.

1993-01-01

Current drive experiments have been performed on the DIII-D tokamak using fast waves, electron cyclotron waves, and neutral injection. Fast wave experiments were performed using a 4-strap antenna with 1 MW of power at 60 MHz. These experiments showed effective heating of electrons, with a global heating efficiency equivalent to that of neutral injection even when the single pass damping was calculated to be as small as 5%. The damping was probably due to the effect of multiple passes of the wave through the plasma. Fast wave current drive experiments were performed with a toroidally directional phasing of the antenna straps. Currents driven by fast wave current drive (FWCD) in the direction of the main plasma current of up to 100 kA were found, not including a calculated 40 kA of bootstrap current. Experiments with FWCD in the counter current direction showed little current drive. In both cases, changes in the sawtooth behavior and the internal inductance qualitatively support the measurement of FWCD. Experiments on electron cyclotron current drive have shown that 100 kA of current can be driven by 1 MW of power at 60 GHz. Calculations with a Fokker-Planck code show that electron cyclotron current drive (ECCD) can be well predicted when the effects of electron trapping and of the residual electric field are included. Experiments on driving current with neutral injection showed that effective current drive could be obtained and discharges with full current drive were demonstrated. Interestingly, all of these methods of current drive had about the same efficiency. (Author)

Self-consistent Study of Fast Particle Redistribution by Alfven Eigenmodes During Ion Cyclotron Resonance Heating

International Nuclear Information System (INIS)

Bergkvist, T.; Hellsten, T.; Johnson, T.

2006-01-01

Alfven eigenmodes (AEs) excited by fusion born α particles can degrade the heating efficiency of a burning plasma and throw out αs. To experimentally study the effects of excitation of AEs and the redistribution of the fast ions, ion cyclotron resonance heating (ICRH) is often used. The distribution function of thermonuclear αs in a reactor is expected to be isotropic and constantly renewed through DT reactions. The distribution function of cyclotron heated ions is strongly anisotropic, and the ICRH do not only renew the distribution function but also provide a strong decorrelation mechanism between the fast ions and the AE. Because of the sensitivity of the AE dynamics on the details of the distribution function, the location of the resonance surfaces in phase space and the extent of the overlapping resonant regions for different AEs, a self-consistent treatment of the AE excitation and the ICRH is necessary. Interactions of fast ions with AEs during ICRH has been implemented in the SELFO code. Simulations are in good agreement with the experimentally observer pitch-fork splitting and rapid damping of the AE as ICRH is turned off. The redistribution of fast ions have been studied in the presence of several driven AEs. (author)

The role of NPY in learning and memory.

Science.gov (United States)

Gøtzsche, C R; Woldbye, D P D

2016-02-01

High levels of NPY expression in brain regions important for learning and memory together with its neuromodulatory and neurotrophic effects suggest a regulatory role for NPY in memory processes. Therefore it is not surprising that an increasing number of studies have provided evidence for NPY acting as a modulator of neuroplasticity, neurotransmission, and memory. Here these results are presented in relation to the types of memory affected by NPY and its receptors. NPY can exert both inhibitory and stimulatory effects on memory, depending on memory type and phase, dose applied, brain region, and NPY receptor subtypes. Thus NPY act as a resilience factor by impairing associative implicit memory after stressful and aversive events, as evident in models of fear conditioning, presumably via Y1 receptors in the amygdala and prefrontal cortex. In addition, NPY impairs acquisition but enhances consolidation and retention in models depending on spatial and discriminative types of associative explicit memory, presumably involving Y2 receptor-mediated regulations of hippocampal excitatory transmission. Moreover, spatial memory training leads to increased hippocampal NPY gene expression that together with Y1 receptor-mediated neurogenesis could constitute necessary steps in consolidation and long-term retention of spatial memory. Altogether, NPY-induced effects on learning and memory seem to be biphasic, anatomically and temporally differential, and in support of a modulatory role of NPY at keeping the system in balance. Obtaining further insight into memory-related effects of NPY could inspire the engineering of new therapeutics targeting diseases where impaired learning and memory are central elements. Copyright © 2015 Elsevier Ltd. All rights reserved.

Current drive with fast waves, electron cyclotron waves, and neutral injection in the DIII-D tokamak

International Nuclear Information System (INIS)

Prater, R.; Petty, C.C.; Pinsker, R.I.; Chiu, S.C.; deGrassie, J.S.; Harvey, R.W.; Ikel, H.; Lin-Liu, Y.R.; Luce, T.C.; James, R.A.; Porkolab, M.; Baity, F.W.; Goulding, R.H.; Hoffmann, D.J.; Kawashima, H.; Trukhin, V.

1992-09-01

Current drive experiments have been performed on the DIII-D tokamak using fast waves, electron cyclotron waves, and neutral injection. Fast wave experiments were performed using a 4-strap antenna with 1 MW of power at 60 MHz. These experiments showed effective heating of electrons, with a global heating efficiency equivalent to that of neutral injection even when the single pass damping was calculated to be as small as 5%. The damping was probably due to the effect of multiple passes of the wave through the plasma. Fast wave current drive experiments were performed with a toroidally directional phasing of the antenna straps. Currents driven by fast wave current drive (FWCD) in the direction of the main plasma current of up to 100 kA were found, not including a calculated 40 kA of bootstrap current. Experiments with FWCD in the counter current direction showed little current drive. In both cases, changes in the sawtooth behavior and the internal inductance qualitatively support the measurement of FWCD. Experiments on electron cyclotron current drive have shown that 100 kA of current can be driven by 1 MW of power at 60 GHz. Calculations with a Fokker-Planck code show that electron cyclotron current drive (ECCD) can be well predicted when the effects of electron trapping and of the residual electric field are included. Experiments on driving current with neutral injection showed that effective current drive could be obtained and discharges with full current drive were demonstrated. Interestingly, all of these methods of current drive had about the same efficiency, 0.015 x 10 20 MA/MW/m 2

Absorption of fast waves at moderate to high ion cyclotron harmonics on DIII-D

International Nuclear Information System (INIS)

Pinsker, R.I.; Porkolab, M.; Heidbrink, W.W.; Luo, Y.; Petty, C.C.; Prater, R.; Choi, M.; Schaffner, D.A.; Baity, F.W.; Fredd, E.; Hosea, J.C.; Harvey, R.W.; Smirnov, A.P.; Murakami, M.; Zeeland, M.A. Van

2006-01-01

The absorption of fast Alfven waves (FW) by ion cyclotron harmonic damping in the range of harmonics from 4th to 8th is studied theoretically and with experiments in the DIII-D tokamak. A formula for linear ion cyclotron absorption on ions with an arbitrary distribution function which is symmetric about the magnetic field is used to estimate the single-pass damping for various cases of experimental interest. It is found that damping on fast ions from neutral beam injection can be significant even at the 8th harmonic if the fast ion beta, the beam injection energy and the background plasma density are high enough and the beam injection geometry is appropriate. The predictions are tested in several L-mode experiments in DIII-D with FW power at 60 MHz and at 116 MHz. It is found that 4th and 5th harmonic absorption of the 60 MHz power on the beam ions can be quite strong, but 8th harmonic absorption of the 116 MHz power appears to be weaker than expected. The linear modelling predicts a strong dependence of the 8th harmonic absorption on the initial pitch-angle of the injected beam, which is not observed in the experiment. Possible explanations of the discrepancy are discussed

The role of NPY in learning and memory

DEFF Research Database (Denmark)

Gøtzsche, C. R.; Woldbye, D. P. D.

2016-01-01

with Y1 receptor-mediated neurogenesis could constitute necessary steps in consolidation and long-term retention of spatial memory. Altogether, NPY-induced effects on learning and memory seem to be biphasic, anatomically and temporally differential, and in support of a modulatory role of NPY at keeping......High levels of NPY expression in brain regions important for learning and memory together with its neuromodulatory and neurotrophic effects suggest a regulatory role for NPY in memory processes. Therefore it is not surprising that an increasing number of studies have provided evidence for NPY...... acting as a modulator of neuroplasticity, neurotransmission, and memory. Here these results are presented in relation to the types of memory affected by NPY and its receptors. NPY can exert both inhibitory and stimulatory effects on memory, depending on memory type and phase, dose applied, brain region...

Intraperitoneal injection of neuropeptide Y (NPY) alters neurotrophin rat hypothalamic levels: Implications for NPY potential role in stress-related disorders.

Science.gov (United States)

Gelfo, Francesca; De Bartolo, Paola; Tirassa, Paola; Croce, Nicoletta; Caltagirone, Carlo; Petrosini, Laura; Angelucci, Francesco

2011-06-01

Neuropeptide Y (NPY) is a 36-amino acid peptide which exerts several regulatory actions within peripheral and central nervous systems. Among NPY actions preclinical and clinical data have suggested that the anxiolytic and antidepressant actions of NPY may be related to its antagonist action on the hypothalamic-pituitary-adrenal (HPA) axis. The neurotrophins brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are proteins involved in the growth, survival and function of neurons. In addition to this, a possible role of neurotrophins, particularly BDNF, in HPA axis hyperactivation has been proposed. To characterize the effect of NPY on the production of neurotrophins in the hypothalamus we exposed young adult rats to NPY intraperitoneal administration for three consecutive days and then evaluated BDNF and NGF synthesis in this brain region. We found that NPY treatment decreased BDNF and increased NGF production in the hypothalamus. Given the role of neurotrophins in the hypothalamus, these findings, although preliminary, provide evidence for a role of NPY as inhibitor of HPA axis and support the idea that NPY might be involved in pathologies characterized by HPA axis dysfunctions. Copyright © 2011 Elsevier Inc. All rights reserved.

Fast-scanning heterodyne receiver for measurement of the electron cyclotron emission from high-temperature plasmas

International Nuclear Information System (INIS)

Efthimion, P.C.; Arunasalam, V.; Bitzer, R.; Campbell, L.; Hosea, J.C.

1979-03-01

A fast-scanning heterodyne receiver was developed that measures the fundamental cyclotron emission from the PLT plasma and thus ascertains the time evolution of the electron temperature profile. The receiver scans 60 to 90 GHz every 10 milliseconds and is interfaced to a computer for completely automated calibrated temperature measurements

A gyrokinetic calculation of transmission and reflection of the fast wave in the ion cyclotron range of frequencies

International Nuclear Information System (INIS)

Lashmore-Davies, C.N.; Fuchs, V.; Dendy, R.O.

1993-01-01

A full-wave equation has been obtained from the gyrokinetic theory for the fast wave traversing a minority cyclotron resonance [Phys. Fluids B 4, 493 (1992)] with the aid of the fast wave approximation [Phys. Fluids 31, 1614 (1988)]. This theory describes the transmission, reflection, and absorption of the fast wave for arbitrary values of the parallel wave number. For oblique propagation the absorption is due to both ion cyclotron damping by minority ions and mode conversion to the ion Bernstein wave. The results for a 3 He minority in a D plasma indicate that for perpendicular propagation and minority temperatures of a few keV the power lost by the fast wave is all mode converted whereas for minority temperatures ∼100 keV∼30% of the incident power is dissipated by the minority ions due to the gyrokinetic correction. The gyrokinetic correction also results in a significant reduction in the reflection coefficient for low field side incidence when k zLB approx-lt 1 and the minority and hybrid resonances overlap

Regulation of hypothalamic NPY by diet and smoking.

Science.gov (United States)

Chen, Hui; Hansen, Michelle J; Jones, Jessica E; Vlahos, Ross; Bozinovski, Steve; Anderson, Gary P; Morris, Margaret J

2007-02-01

Appetite is regulated by a number of hypothalamic neuropeptides including neuropeptide Y (NPY), a powerful feeding stimulator that responds to feeding status, and drugs such as nicotine and cannabis. There is debate regarding the extent of the influence of obesity on hypothalamic NPY. We measured hypothalamic NPY in male Sprague-Dawley rats after short or long term exposure to cafeteria-style high fat diet (32% energy as fat) or laboratory chow (12% fat). Caloric intake and body weight were increased in the high fat diet group, and brown fat and white fat masses were significantly increased after 2 weeks. Hypothalamic NPY concentration was only significantly decreased after long term consumption of the high fat diet. Nicotine decreases food intake and body weight, with conflicting effects on hypothalamic NPY reported. Body weight, plasma hormones and brain NPY were investigated in male Balb/c mice exposed to cigarette smoke for 4 days, 4 and 12 weeks. Food intake was significantly decreased by smoke exposure (2.32+/-0.03g/24h versus 2.71+/-0.04g/24h in control mice (non-smoke exposed) at 12 weeks). Relative to control mice, smoke exposure led to greater weight loss, while pair-feeding the equivalent amount of chow caused an intermediate weight loss. Chronic smoke exposure, but not pair-feeding, was associated with decreased hypothalamic NPY concentration, suggesting an inhibitory effect of cigarette smoking on brain NPY levels. Thus, consumption of a high fat diet and smoke exposure reprogram hypothalamic NPY. Reduced NPY may contribute to the anorexic effect of smoke exposure.

The Neuropsychiatric Inventory--NPI. Validation of the Danish version

DEFF Research Database (Denmark)

Korner, A.; Lauritzen, Lotte; Lolk, A.

2008-01-01

NPI and NPI-VAS were high; only two domains had coefficients below 0.60: depression and agitation/aggression. NPI-total scores increase with increasing severity of dementia. The NPI did not fulfil the scalability assessed by the Mokken and Loevinger coefficients. The NPI Danish version is valid......Assessment of neuropsychiatric symptoms in dementia has great clinical importance. The aim of the study was validation of the Danish version of the NPI, using assessments of 72 demented and 29 non-demented of age 65+ years and their caregivers at three visits. The NPI was administered by the same...... and reliable in assessing neuropsychiatric symptoms in dementia but not fully scalable. The use of single item scores and not total sum score is recommended Udgivelsesdato: 2008...

2-D time evolution of T/sub e/ during sawtooth crash based on fast ECE [electron cyclotron emission] measurements on TFTR

International Nuclear Information System (INIS)

Kuo-Petravic, G.

1988-12-01

Electron cyclotron emission measurements taken at 20 locations in the horizontal midplane during a sawtooth crash have been analysed based on the assumption of fast rigid rotation of the plasma. Due to this fast rotation (∼100μsec), which remains fairly constant throughout the sawtooth crash, we have been able to make time-to-space reconstructions of half the poloidal plane using points which are separated in time by not more than 40μsec. The existence of a temperature flattening in the precursor phase, which we interpret as an m = 1 temperature island, is clearly demonstrated, and its location and width agree well with local emissivity measurements from soft x-ray tomography viewing the same poloidal plane. The rotating temperature island in the precursor phase, the outward movement of the region of high T/sub c/ during the crash phase, and the shape of T/sub e/ during the crash phase, and the shape of T/sub e/ distribution after the crash during the successor phase have all been documented in a time sequence of color contours. 4 refs., 10 figs

Knowledge and experiences of needle prick injuries (NPI) among ...

African Journals Online (AJOL)

Data collected included factors contributing to NPI and high-risk procedures leading to NPI, as perceived by these students. A knowledge assessment of NPI guidelines, policies and protocols and prevalence of NPI among these students was also done. Results: A response rate of 96 (74%) was achieved. The average age ...

Cyclotron-based neutron source for BNCT

Energy Technology Data Exchange (ETDEWEB)

Mitsumoto, T.; Yajima, S.; Tsutsui, H.; Ogasawara, T.; Fujita, K. [Sumitomo Heavy Industries, Ltd (Japan); Tanaka, H.; Sakurai, Y.; Maruhashi, A. [Kyoto University Research Reactor Institute (Japan)

2013-04-19

Kyoto University Research Reactor Institute (KURRI) and Sumitomo Heavy Industries, Ltd. (SHI) have developed a cyclotron-based neutron source for Boron Neutron Capture Therapy (BNCT). It was installed at KURRI in Osaka prefecture. The neutron source consists of a proton cyclotron named HM-30, a beam transport system and an irradiation and treatment system. In the cyclotron, H- ions are accelerated and extracted as 30 MeV proton beams of 1 mA. The proton beams is transported to the neutron production target made by a beryllium plate. Emitted neutrons are moderated by lead, iron, aluminum and calcium fluoride. The aperture diameter of neutron collimator is in the range from 100 mm to 250 mm. The peak neutron flux in the water phantom is 1.8 Multiplication-Sign 109 neutrons/cm{sup 2}/sec at 20 mm from the surface at 1 mA proton beam. The neutron source have been stably operated for 3 years with 30 kW proton beam. Various pre-clinical tests including animal tests have been done by using the cyclotron-based neutron source with {sup 10}B-p-Borono-phenylalanine. Clinical trials of malignant brain tumors will be started in this year.

ULTRA-LOW INTENSITY PROTON BEAMS FOR RADIATION RESPONSE RELATED EXPERIMENTS AT THE U-120M CYCLOTRON

Directory of Open Access Journals (Sweden)

Tomas Matlocha

2018-05-01

Full Text Available The U-120M cyclotron at the Nuclear Physics Institute (NPI of the Czech Academy of Sciences in Rez is used for radiation hardness tests of electronics for high-energy physics experiments. These tests are usually carried out with proton fluxes of the order of 105–109 proton·cm−2·s−1. Some tests done for the upgrade of the Inner Tracking System of the ALICE experiment at CERN, however, required proton beam intensities several orders of magnitude lower. This paper presents a method which has been developed to achieve the proton beam flux of the order of 1 proton · cm−2·s−1. The method is mainly based on reduction of the discharge current in the cyclotron internal Penning type ion source. Influence of this new operation mode on the lifetime of ion source cathodes is discussed.

NPY gene transfer in the hippocampus attenuates synaptic plasticity and learning

DEFF Research Database (Denmark)

Sørensen, Andreas T; Kanter-Schlifke, Irene; Carli, Mirjana

2008-01-01

-mediated mechanisms. In addition, transgene NPY seems to be released during high frequency neuronal activity, leading to decreased glutamate release in excitatory synapses. Importantly, memory consolidation appears to be affected by the treatment. We found that long-term potentiation (LTP) in the CA1 area...... processing. Here we show, by electrophysiological recordings in CA1 of the hippocampal formation of rats, that hippocampal NPY gene transfer into the intact brain does not affect basal synaptic transmission, but slightly alters short-term synaptic plasticity, most likely via NPY Y2 receptor....... Future clinical progress, however, requires more detailed evaluation of possible side effects of this treatment. Until now it has been unknown whether rAAV vector-based NPY overexpression in the hippocampus alters normal synaptic transmission and plasticity, which could disturb learning and memory...

Dependency-dependent interference: NPI interference, agreement attraction, and global pragmatic inferences

Directory of Open Access Journals (Sweden)

Ming eXiang

2013-10-01

Full Text Available Previous psycholinguistics studies have shown that when forming a long distance dependency in online processing, the parser sometimes accepts a sentence even though the required grammatical constraints are only partially met. A mechanistic account of how such errors arise sheds light on both the underlying linguistic representations involved and the processing mechanisms that put such representations together. In the current study, we contrast the NPI (negative polarity items interference effect, as shown by the acceptance of an ungrammatical sentence like The bills that democratic senators have voted for will ever become law, with the well-known phenomenon of agreement attraction (The key to the cabinets are…. On the surface, these two types of errors look alike and thereby can be explained as being driven by the same source: similarity based memory interference. However, we argue that the linguistic representations involved in NPI licensing are substantially different from those of subject-verb agreement, and therefore the interference effects in each domain potentially arise from distinct sources. In particular, we show that NPI interference at least partially arises from pragmatic inferences. In a self-paced reading study with an acceptability judgment task, we showed NPI interference was modulated by participants’ general pragmatic communicative skills, as quantified by the Autism-Spectrum Quotient (Baron-Cohen 2001, especially in offline tasks. Participants with more autistic traits were actually less prone to the NPI interference effect than those with fewer autistic traits. This result contrasted with agreement attraction conditions, which were not influenced by individual pragmatic skill differences. We also show that different NPI licensors have distinct interference profiles. We discuss two kinds of interference effects for NPI licensing: memory-retrieval based and pragmatically triggered.

Study and impact of fast electrons diagnosed by electron cyclotron radiation on Tore-Supra tokamak

International Nuclear Information System (INIS)

Gomez, P.

1999-12-01

This thesis aims at characterizing the dynamics of fast electrons generated by the Landau absorption of the hybrid wave and studying their effects on electron cyclotron radiation. The different processes involved in the propagation and resonant absorption of the hybrid wave in plasmas are described. A method such as ray-tracing allows the characterization of the dynamics of heating but this method relies on the hypothesis of geometrical optics. Whenever absorption rate is low as it is in Tore-Supra, the hybrid wave undergoes a series of successive reflections on the edge of the plasma before being completely absorbed. These reflections generate an electromagnetic chaos in which geometrical optics hypothesis are no longer valid. A statistical treatment of the Fokker-Planck equation allows the calculation of the mean distribution function of electrons in the plasma submitted to hybrid wave. The electron cyclotron radiation is then deduced and by assuming that plasma behaves like a black body, a theoretical radiative temperature is calculated. The confrontation of this theoretical temperature profile with experimental values allows the validation of this modeling and the estimation of the effects of fast electrons on temperature measurements. (A.C.)

Validity of the Brazilian version of the Neuropsychiatric Inventory Questionnaire (NPI-Q

Directory of Open Access Journals (Sweden)

Ana Luiza Camozzato

2015-01-01

Full Text Available The NPI-Q (Neuropsychiatry Inventory-Questionnaire was developed to facilitate the evaluation of neuropsychiatric symptoms. This study evaluated the internal consistency, the test-retest reliability of the Brazilian NPI-Q version and its convergent validity with the original NPI. Method The NPI-Q and the NPI were administered to 64 caregivers of dementia patients. Thirteen informants were asked to complete a second NPI-Q form. Results The internal consistency of the Brazilian NPI-Q version was 0.67 for the severity scale and 0.81 for the distress scale. The test-retest reliability of the total NPI-Q severity and the distress scales were 0.97 and 0.92, respectively (p < 0.001. There were significant correlations between the total NPI-Q severity score and the NPI (r = 0.75 and between the total NPI-Q distress score and the total NPI standard distress (r = 0.74. Conclusion The Brazilian NPI-Q version showed evidence of good psychometric properties and can be used in general clinical practice.

Release of NPY in pig pancreas: Dual parasympathetic and sympathetic regulation

International Nuclear Information System (INIS)

Sheikh, S.P.; Holst, J.J.; Skak-Nielsen, T.; Knigge, U.; Warberg, J.; Theodorsson-Norheim, E.; Hoekfelt, T.; Lundberg, J.M.; Schwartz, T.W.

1988-01-01

Several lines of evidence have connected neuropeptide Y (NPY), a 36-residue polypeptide, to the sympathetic division of the autonomic nervous system. The authors studied the localization, the molecular characteristics, and the release of NPY and norepinephrine (NE) in the porcine pancreas. Immunohistochemical investigations revealed that NPY nerves around blood vessels were likely to be of adrenergic nature, whereas NPY-immunoreactive fibers close to exocrine and endocrine cells may originate from local ganglia also containing VIP (vasoactive intestinal peptide) and PHI (peptide histidine isoleucine). Electrical stimulation of the splanchnic nerve supply to the isolated perfused pig pancreas resulted in a corelease of NPY and NE into the venous effluent. Stimulation of the vagal nerves caused a sevenfold larger release of NPY without affecting the NE secretion. Characterization of the NPY immunoreactivity in the pancreatic tissue and in the venous effluent by gel filtration, high-performance liquid chromatography, and isoelectric focusing shoed that the immunoreactive NPY was indistinguishable from synthetic porcine NPY. It is concluded that, although NPY is associated with sympathetic perivascular neurons, the majority of the pancreatic NPY-containing nerve fibers are likely to belong to the parasympathetic division of the autonomic nervous system

Knowledge based operation assist system for JAERI AVF cyclotron

International Nuclear Information System (INIS)

Agematsu, T.; Okumura, S.; Yokota, W.; Arakawa, K.; Murakami, T.; Okamura, T.

1992-01-01

We have developed two operation assist systems for easy and rapid operation of the JAERI AVF cyclotron. One is a knowledge based expert system guiding the sequence of parameter adjustment to inexperienced cyclotron operators. The other is a real-time simulation of the beam trajectories which are calculated from actual operating parameters. It graphically indicates feasible setting range of parameters that satisfies the acceptance of the cyclotron. These systems provide a human interface to adjust the parameters of the cyclotron. (author)

Neutron radiography by using JSW baby cyclotron

International Nuclear Information System (INIS)

Toda, Yojiro

1995-01-01

At present, JSW baby cyclotrons are mostly used for the production of the radioisotopes for medical use. The attempt to use this baby cyclotron for neutron radiography began already in 1981. The feasibility of the neutron radiography for the explosives in metallic cases which are used for H1 rockets was investigated. In 1983, it was shown that the neutron radiography by using the baby cyclotron in Muroran Works, Japan Steel Works, Ltd. was able to be carried out as a routine work. Since then, the nondestructive inspection by neutron radiography has been performed for rocket pyrotechnic articles, and contributed to heighten their reliability. Further, the radiography by using fast neutrons was developed and put to practical use for recent large H2 rockets. The JSW baby cyclotron BC 168 which has been used for neutron radiography can accelerate 16 MeV protons or 8 MeV deuterons up to 50 μA. The principle of thermal neutron radiography is the generation of fast neutrons by irradiating a Be target with the proton beam accelerated by a baby cyclotron, the moderation of the fast neutrons, the formation of the thermal neutron flux of uniform distribution with a collimator, the thermal neutron flux hitting the Gd plate in a film cassette through an object, and the exposure of an X-ray film to electrons from the Gd plate. Fast neutron radiography apparatus, and commercial neutron radiography are described. (K.I.)

Insulin controls food intake and energy balance via NPY neurons

Directory of Open Access Journals (Sweden)

Kim Loh

2017-06-01

Full Text Available Objectives: Insulin signaling in the brain has been implicated in the control of satiety, glucose homeostasis and energy balance. However, insulin signaling is dispensable in energy homeostasis controlling AgRP or POMC neurons and it is unclear which other neurons regulate these effects. Here we describe an ancient insulin/NPY neuronal network that governs energy homeostasis across phyla. Methods: To address the role of insulin action specifically in NPY neurons, we generated a variety of models by selectively removing insulin signaling in NPY neurons in flies and mice and testing the consequences on energy homeostasis. Results: By specifically targeting the insulin receptor in both fly and mouse NPY expressing neurons, we found NPY-specific insulin signaling controls food intake and energy expenditure, and lack of insulin signaling in NPY neurons leads to increased energy stores and an obese phenotype. Additionally, the lack of insulin signaling in NPY neurons leads to a dysregulation of GH/IGF-1 axis and to altered insulin sensitivity. Conclusions: Taken together, these results suggest that insulin actions in NPY neurons is critical for maintaining energy balance and an impairment of this pathway may be causally linked to the development of metabolic diseases. Keywords: Hypothalamus, NPY, Insulin, Obesity

Optimization approach for saddling cost of medical cyclotrons with fuzziness

International Nuclear Information System (INIS)

Abass, S.A.; Massoud, E.M.A.

2007-01-01

Most radiation fields are combinations of different kinds of radiation. The radiations of most significance are fast neutrons, thermal neutrons, primary gammas and secondary gammas. Thermos's composite shielding materials are designed to attenuate these types of radiation. The shielding design requires an accurate cost-benefit analysis based on uncertainty optimization technique. The theory of fuzzy sets has been employed to formulate and solve the problem of cost-benefit analysis of medical cyclotron. This medical radioisotope production cyclotron is based in Sydney, Australia

Experimental observation of acoustic emissions generated by a pulsed proton beam from a hospital-based clinical cyclotron

International Nuclear Information System (INIS)

Jones, Kevin C.; Solberg, Timothy D.; Avery, Stephen; Vander Stappen, François; Janssens, Guillaume; Prieels, Damien; Bawiec, Christopher R.; Lewin, Peter A.; Sehgal, Chandra M.

2015-01-01

Purpose: To measure the acoustic signal generated by a pulsed proton spill from a hospital-based clinical cyclotron. Methods: An electronic function generator modulated the IBA C230 isochronous cyclotron to create a pulsed proton beam. The acoustic emissions generated by the proton beam were measured in water using a hydrophone. The acoustic measurements were repeated with increasing proton current and increasing distance between detector and beam. Results: The cyclotron generated proton spills with rise times of 18 μs and a maximum measured instantaneous proton current of 790 nA. Acoustic emissions generated by the proton energy deposition were measured to be on the order of mPa. The origin of the acoustic wave was identified as the proton beam based on the correlation between acoustic emission arrival time and distance between the hydrophone and proton beam. The acoustic frequency spectrum peaked at 10 kHz, and the acoustic pressure amplitude increased monotonically with increasing proton current. Conclusions: The authors report the first observation of acoustic emissions generated by a proton beam from a hospital-based clinical cyclotron. When modulated by an electronic function generator, the cyclotron is capable of creating proton spills with fast rise times (18 μs) and high instantaneous currents (790 nA). Measurements of the proton-generated acoustic emissions in a clinical setting may provide a method for in vivo proton range verification and patient monitoring

Cyclotrons with fast variable and/or multiple energy extraction

Directory of Open Access Journals (Sweden)

C. Baumgarten

2013-10-01

Full Text Available We discuss the possibility in principle of stripping extraction in combination with reverse bends in isochronous separate-sector cyclotrons (and/or fixed field alternating gradient accelerators. If one uses reverse bends between the sectors (instead of or in combination with drifts and places stripper foils at the sector exit edges, the stripped beam has a reduced bending radius and it should be able to leave the cyclotron within the range of the valley—even if the beam is stripped at less than full energy. We are especially interested in stripping of H_{2}^{+}, as it doubles the charge to mass ratio of the ions. However the method could be applied to other ions or ionized molecules as well. For the production of proton beams by stripping extraction of an H_{2}^{+} beam, we discuss possible designs for three types of machines: First, a low-energy cyclotron for the simultaneous production of several beams at multiple energies—for instance 15, 30, and 70 MeV—thus allowing beam delivery on several isotope production targets. In this case it can be an advantage to have a strong energy dependence of the direction of the extracted beam. Second, we consider a fast variable-energy proton machine for cancer therapy that should allow extraction (of the complete beam at all energies in the range of about 70 MeV to about 250 MeV into the same beam line. Third, we consider a high-intensity high-energy machine, where the main design goals are extraction with low losses, low activation of components, and high reliability. Especially if such a machine is considered for an accelerator driven system (ADS, this extraction mechanism has advantages: Beam trips by the failure of electrostatic elements could be avoided and the turn separation would be less critical, which allows operation at lower main cavity voltages. This would in turn reduce the number of rf trips. The price that has to be paid for these advantages is an increase in size and/or field

Fast wave heating of two-ion plasmas in the Princeton large torus through minority cyclotron resonance damping

International Nuclear Information System (INIS)

Hosea, J.; Bernabei, S.; Colestock, P.

1979-07-01

Strong minority proton heating is produced in PLT through ion cyclotron resonance damping of fast waves at moderate rf power levels. In addition to demonstrating good proton confinement, the proton energy distribution is consistent with Fokker--Planck theory which provides the prescription for extrapolation of this heating regime to higher rf power levels

Structure and function of the amygdaloid NPY system: NPY Y2 receptors regulate excitatory and inhibitory synaptic transmission in the centromedial amygdala.

Science.gov (United States)

Wood, J; Verma, D; Lach, G; Bonaventure, P; Herzog, H; Sperk, G; Tasan, R O

2016-09-01

The amygdala is essential for generating emotional-affective behaviors. It consists of several nuclei with highly selective, elaborate functions. In particular, the central extended amygdala, consisting of the central amygdala (CEA) and the bed nucleus of the stria terminalis (BNST) is an essential component actively controlling efferent connections to downstream effectors like hypothalamus and brain stem. Both, CEA and BNST contain high amounts of different neuropeptides that significantly contribute to synaptic transmission. Among these, neuropeptide Y (NPY) has emerged as an important anxiolytic and fear-reducing neuromodulator. Here, we characterized the expression, connectivity and electrophysiological function of NPY and Y2 receptors within the CEA. We identified several NPY-expressing neuronal populations, including somatostatin- and calretinin-expressing neurons. Furthermore, in the main intercalated nucleus, NPY is expressed primarily in dopamine D1 receptor-expressing neurons but also in interspersed somatostatin-expressing neurons. Interestingly, NPY neurons did not co-localize with the Y2 receptor. Retrograde tract tracing experiments revealed that NPY neurons reciprocally connect the CEA and BNST. Functionally, the Y2 receptor agonist PYY3-36, reduced both, inhibitory as well as excitatory synaptic transmission in the centromedial amygdala (CEm). However, we also provide evidence that lack of NPY or Y2 receptors results in increased GABA release specifically at inhibitory synapses in the CEm. Taken together, our findings suggest that NPY expressed by distinct populations of neurons can modulate afferent and efferent projections of the CEA via presynaptic Y2 receptors located at inhibitory and excitatory synapses.

Regulation of ion drifts and anisotropies by parametrically unstable finite-amplitude Alfvén-cyclotron waves in the fast solar wind

Energy Technology Data Exchange (ETDEWEB)

Maneva, Y. G. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Araneda, J. A. [Departamento de Física, Universidad de Concepción, 4070386 (Chile); Marsch, E., E-mail: yana.g.maneva@nasa.gov [Institute for Experimental and Applied Physics, Christian Albrechts University at Kiel, D-24118 Kiel (Germany)

2014-03-10

We study the preferential heating and differential acceleration of minor ions by dissipation of ion-acoustic waves (IAWs) generated by parametric instabilities of a finite-amplitude monochromatic Alfvén-cyclotron pump wave. We consider the associated kinetic effects of Landau damping and nonlinear pitch-angle scattering of protons and α particles in the tenuous plasma of coronal holes and the fast solar wind. Various data collected by Wind spacecraft show signatures for a local transverse heating of the minor ions, presumably by Alfvén-cyclotron wave dissipation, and an unexpected parallel heating by a so far unknown mechanism. Here, we present the results from a set of 1.5 dimensional hybrid simulations in search for a plausible explanation for the observed field-aligned kinetic features in the fast solar wind minor ions. We investigate the origin and regulation of ion relative drifts and temperature anisotropies in low plasma β, fast solar wind conditions. Depending on their initial drifts, both ion species can heat up not only transversely through cyclotron resonance and non-resonant wave-particle interactions, but also strongly in the parallel direction by Landau damping of the daughter IAWs. We discuss the dependence of the relative ion drifts and temperature anisotropies on the plasma β of the individual species and we describe the effect of the pump wave amplitude on the ion heating and acceleration.

NPI one year on [Framatome-Siemens common product

International Nuclear Information System (INIS)

Ruess, F.; Lebreton, G.

1990-01-01

Nuclear Power International (NPI), a joint subsidiary of Framatome and Siemens was established in April 1989 to coordinate the development and marketing of a common PWR technology for the world market. Both parent companies command well proven PWR technology and can rely on experience gained with over 100 000MWe of nuclear capacity in operation, under construction or on order. The technology from each is being offered through NPI until the joint PWR technology which is under development, becomes available. NPI's experience to date is reviewed. (author)

Arcuate NPY neurons sense and integrate peripheral metabolic signals to control feeding.

Science.gov (United States)

Kohno, Daisuke; Yada, Toshihiko

2012-12-01

NPY neuron in the hypothalamic arcuate nucleus is a key feeding center. Studies have shown that NPY neuron in the arcuate nucleus has a role to induce food intake. The arcuate nucleus is structurally unique with lacking blood brain barrier. Peripheral energy signals including hormones and nutrition can reach the arcuate nucleus. In this review, we discuss sensing and integrating peripheral signals in NPY neurons. In the arcuate nucleus, ghrelin mainly activates NPY neurons. Leptin and insulin suppress the ghrelin-induced activation in 30-40% of the ghrelin-activated NPY neurons. Lowering glucose concentration activates 40% of NPY neurons. These results indicate that NPY neuron in the arcuate nucleus is a feeding center in which major peripheral energy signals are directly sensed and integrated. Furthermore, there are subpopulations of NPY neurons in regard to their responsiveness to peripheral signals. These findings suggest that NPY neuron in the arcuate nucleus is an essential feeding center to induce food intake in response to peripheral metabolic state. Copyright © 2012 Elsevier Ltd. All rights reserved.

New development of neutron radiography with a small cyclotron

International Nuclear Information System (INIS)

Ikeda, Yasushi; Ohkubo, Kohei; Kato, Toshihiko; Nakamura, Tomihisa; Fuji, Takayoshi.

1990-01-01

A series of neutron radiography testing has been performed for several years by using a small accelerator called 'Baby Cyclotron' manufactured by Japan Steel Works, Ltd. The Baby Cyclotron produces fast neutrons at the rate of 4x10 12 n/cm 2 s, and enables to perform neutron radiography imaging by various techniques. The most important application of this Baby Cyclotron radiography system is the non-destructive testing (NDT) of various explosive devices prepared for space launch vehicles. It is assured that thermal neutron radiography testing is a very useful means for the NDT. Also fast neutron radiography testing is in progress. The fast neutron radiography with a CR39 track-etch image recorder was developed, and it was shown to be the very useful NDT means when the thicker objects used for new H-2 launch vehicles had to be examined. Because thermal neutron radiography has the high detectability of hydrogenous materials, organic elastomers such as O-rings and explosive powder are clearly observable through the opaque steel walls of containers. The Baby Cyclotron and the neutron radiography facility, thermal neutron and fast neutron radiography testings and so on are reported. (K.I.)

Neuropeptide Y (NPY) and peptide YY (PYY) receptors in rat brain

International Nuclear Information System (INIS)

Ohkubo, T.; Niwa, M.; Yamashita, K.; Kataoka, Y.; Shigematsu, K.

1990-01-01

1. Specific binding sites for neuropeptide Y (NPY) and peptide YY (PYY) were investigated in rat brain areas using quantitative receptor autoradiography with 125 I-Bolton-Hunter NPY ( 125 I-BH-NPY) and 125 I-PYY, radioligands for PP-fold family peptides receptors. 2. There were no differences between localization of 125 I-BH-NPY and 125 I-PYY binding sites in the rat brain. High densities of the binding sites were present in the anterior olfactory nucleus, lateral septal nucleus, stratum radiatum of the hippocampus, posteromedial cortical amygdaloid nucleus, and area postrema. 3. In cold ligand-saturation experiments done in the presence of increasing concentrations of unlabeled NPY and PYY, 125 I-BH-NPY and 125 I-PYY binding to the stratum radiatum of the hippocampus, layer I of the somatosensory frontoparietal cortex, molecular layer of the cerebellum, and area postrema was single and of a high affinity. There was a significant difference between the affinities of 125 I-BH-NPY (Kd = 0.96 nM) and 125 I-PYY binding (Kd = 0.05 nM) to the molecular layer of the cerebellum. The binding of the two radioligands to the other areas examined had the same affinities. 4. When comparing the potency of unlabeled rat pancreatic polypeptide (rPP), a family peptide of NPY and PYY, to inhibit the binding to the areas examined, rPP displaced 125 I-BH-NPY and 125 I-PYY binding to the area postrema more potently than it did the binding to the stratum radiatum of the hippocampus, layer I of the somatosensory frontoparietal cortex, and molecular layer of the cerebellum. 5. Thus, the quantitative receptor autoradiographic method with 125 I-BH-NPY and 125 I-PYY revealed differences in binding characteristics of specific NPY and PYY binding sites in different areas of the rat brain. The results provide further evidence for the existence of multiple NPY-PYY receptors in the central nervous system

Effects of NPY and the specific Y1 receptor agonist [D-His(26)]-NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats.

Science.gov (United States)

Rylkova, Daria; Boissoneault, Jeffrey; Isaac, Shani; Prado, Melissa; Shah, Hina P; Bruijnzeel, Adrie W

2008-06-01

Tobacco addiction is a chronic disorder that is characterized by dysphoria upon smoking cessation and relapse after periods of abstinence. Previous research suggests that Neuropeptide Y (NPY) and Y1 receptor agonists attenuate negative affective states and somatic withdrawal signs. The aim of the present experiments was to investigate the effects of NPY and the specific Y1 receptor agonist [D-His(26)]-NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats. The intracranial self-stimulation procedure was used to assess the effects of nicotine withdrawal on brain reward function as this procedure can provide a quantitative measure of emotional states in rodents. Elevations in brain reward thresholds are indicative of a deficit in brain reward function. In the first experiment, NPY did not prevent the elevations in brain reward thresholds associated with precipitated nicotine withdrawal and elevated the brain reward thresholds of the saline-treated control rats. Similar to NPY, [D-His(26)]-NPY did not prevent the elevations in brain reward thresholds associated with precipitated nicotine withdrawal and elevated the brain reward thresholds of the saline-treated control rats. Neither NPY nor [D-His(26)]-NPY affected the response latencies. In a separate experiment, it was demonstrated that the specific Y1 receptor antagonist BIBP-3226 prevented the NPY-induced elevations in brain reward thresholds. NPY attenuated the overall somatic signs associated with precipitated nicotine withdrawal. [D-His(26)]-NPY did not affect the overall somatic signs associated with precipitated nicotine withdrawal, but decreased the number of abdominal constrictions. Both NPY and [D-His(26)]-NPY attenuated the overall somatic signs associated with spontaneous nicotine withdrawal. These findings indicate that NPY and [D-His(26)]-NPY attenuate somatic nicotine withdrawal signs, but do not prevent the deficit in brain reward function associated

Cyclotron based nuclear science. Progress report, April 1, 1985-March 31, 1986

International Nuclear Information System (INIS)

Youngblood, D.H.

1986-08-01

Progress report for cyclotron based nuclear science cyclotron facility are summarized. Research is described under the headings heavy ion reactions, nuclear theory, atomic studies and activation analysis, superconducting cyclotron and instrumentation. Publications are listed

Changes in the nutritional quality of fast-food items marketed at restaurants, 2010 v. 2013.

Science.gov (United States)

Soo, Jackie; Harris, Jennifer L; Davison, Kirsten K; Williams, David R; Roberto, Christina A

2018-03-27

To examine the nutritional quality of menu items promoted in four (US) fast-food restaurant chains (McDonald's, Burger King, Wendy's, Taco Bell) in 2010 and 2013. Menu items pictured on signs and menu boards were recorded at 400 fast-food restaurants across the USA. The Nutrient Profile Index (NPI) was used to calculate overall nutrition scores for items (higher scores indicate greater nutritional quality) and was dichotomized to denote healthier v. less healthy items. Changes over time in NPI scores and energy of promoted foods and beverages were analysed using linear regression. Four hundred fast-food restaurants (McDonald's, Burger King, Wendy's, Taco Bell; 100 locations per chain). NPI of fast-food items marketed at fast-food restaurants. Promoted foods and beverages on general menu boards and signs remained below the 'healthier' cut-off at both time points. On general menu boards, pictured items became modestly healthier from 2010 to 2013, increasing (mean (se)) by 3·08 (0·16) NPI score points (Prestaurants showed limited improvements in nutritional quality in 2013 v. 2010.

Cyclotron Development and Technical Aspects on Accelerator Based Laboratory Development

International Nuclear Information System (INIS)

Sunarhadijoso

2000-01-01

BATAN is planning to establish an accelerator-based laboratory at P3TM Yogyakarta as an effort in the development and use of accelerator technology for improving industrial performance and public welfare. This paper reviews several aspects of cyclotron technology and describes the combination of a linear accelerator - cyclotron system as an alternative to be considered in the planing of the laboratory. The progress of cyclotron technology is discussed covering three generations, i.e. conventional cyclotron, synchrocyclotron and AVF cyclotron generations. The planning should not consider the accelerator application for radioisotope production because it is established in Serpong with the existing negative ion cyclotron. The proposed facility at P3TM may comprise two linear accelerators coupled with a positive ion cyclotron of synchrocyclotron generation. In fact, the attachment of the synchrocyclotron unit is flexible and it can be installed subsequently if the higher energy particle beam, which can not be produced by the linear accelerators, is extremely needed. Some technical aspects related to ion beam application, building construction and infrastructure, human resources, and specification of function test are discussed for additional information in the implementation of the planning. (author)

Study of the fast electron distribution function in lower hybrid and electron cyclotron current driven plasmas in the WT-3 tokamak

International Nuclear Information System (INIS)

Ogura, K.; Tanaka, H.; Ide, S.

1991-01-01

The distribution function f(p-vector) of fast electrons produced by lower hybrid current drive (LHCD) is investigated in the WT-3 tokamak, using a combination of measurements of the hard X-ray (HXR) angular distribution with respect to the toroidal magnetic field and observations of the HXR radial profile. The data obtained indicate the formation of a plateau-like region in f(p-vector) which corresponds to a region of resonant interaction between the lower hybrid (LH) wave and the electrons. The energy of the fast electrons in the peripheral plasma region is observed to be higher than that in the central plasma region under operational conditions with a high plasma current (I p ≥ 80 kA). At low current (I p < or approx. 50 kA), however, the energy of fast electrons is constant along the plasma radius. In the current ramp-up phase, fast electrons are generated in the directions normal to and opposite to the LH wave propagation. The latter case is ascribed to a negatively biased toroidal electric field induced by the current ramp-up. To study the characteristic change of f(p-vector) for various current drive mechanisms, HXR measurements are performed in electron cyclotron current driven (ECCD) plasma and in Ohmic heating (OH) plasma. In ECCD plasma, the perpendicular energy of fast electrons increases, which indicates that fast electrons are accelerated perpendicularly by electron cyclotron heating. In both LHCD and ECCD plasmas, fast electrons flow in the direction opposite to the wave propagation, while no such fast electrons are formed in OH plasma. (author). 33 refs, 16 figs, 1 tab

Biomedical cyclotron facility

International Nuclear Information System (INIS)

MacDonald, N.S.; Birdsall, R.; Takahaski, J.; McConnel, L.; Wood, R.; Wakakuwa, S.

1976-01-01

During the fifth year of operation the mechanical performance of the cyclotron and accessory equipment was excellent. Major items put into operation were a small computer system interfaced with Ge-Li gamma spectrometer and a pneumatic-tube system for fast delivery of short-lived radionuclides. A table is presented listing the radionuclides produced

Direct versus indirect actions of ghrelin on hypothalamic NPY neurons.

Science.gov (United States)

Hashiguchi, Hiroshi; Sheng, Zhenyu; Routh, Vanessa; Gerzanich, Volodymyr; Simard, J Marc; Bryan, Joseph

2017-01-01

Assess direct versus indirect action(s) of ghrelin on hypothalamic NPY neurons. Electrophysiology was used to measure ion channel activity in NPY-GFP neurons in slice preparations. Ca2+ imaging was used to monitor ghrelin activation of isolated NPY GFP-labeled neurons. Immunohistochemistry was used to localize Trpm4, SUR1 and Kir6.2 in the hypothalamus. Acylated ghrelin depolarized the membrane potential (MP) of NPY-GFP neurons in brain slices. Depolarization resulted from a decreased input resistance (IR) in ~70% of neurons (15/22) or an increased IR in the remainder (7/22), consistent with the opening or closing of ion channels, respectively. Although tetrodotoxin (TTX) blockade of presynaptic action potentials reduced ghrelin-induced changes in MP and IR, ghrelin still significantly depolarized the MP and decreased IR in TTX-treated neurons, suggesting that ghrelin directly opens cation channel(s) in NPY neurons. In isolated NPY-GFP neurons, ghrelin produced a sustained rise of [Ca2+]c, with an EC50 ~110 pM. Pharmacologic studies confirmed that the direct action of ghrelin was through occupation of the growth hormone secretagogue receptor, GHS-R, and demonstrated the importance of the adenylate cyclase/cAMP/protein kinase A (PKA) and phospholipase C/inositol triphosphate (PLC/IP3) pathways as activators of 5' AMP-activated protein kinase (AMPK). Activation of isolated neurons was not affected by CNQX or TTX, but reducing [Na+]o suppressed activation, suggesting a role for Na+-permeable cation channels. SUR1 and two channel partners, Kir6.2 and Trpm4, were identified immunologically in NPY-GFP neurons in situ. The actions of SUR1 and Trpm4 modulators were informative: like ghrelin, diazoxide, a SUR1 agonist, elevated [Ca2+]c and glibenclamide, a SUR1 antagonist, partially suppressed ghrelin action, while 9-phenanthrol and flufenamic acid, selective Trpm4 antagonists, blocked ghrelin actions on isolated neurons. Ghrelin activation was unaffected by nifedipine and

Superconducting cyclotrons

International Nuclear Information System (INIS)

Blosser, H.G.; Johnson, D.A.; Burleigh, R.J.

1976-01-01

Superconducting cyclotrons are particularly appropriate for acceleration of heavy ions. A review is given of design features of a superconducting cyclotron with energy 440 (Q 2 /A) MeV. A strong magnetic field (4.6 tesla average) leads to small physical size (extraction radius 65 cm) and low construction costs. Operating costs are also low. The design is based on established technology (from present cyclotrons and from large bubble chambers). Two laboratories (in Chalk River, Canada and in East Lansing, Michigan) are proceeding with construction of full-scale prototype components for such cyclotrons

Proton and deuteron activation measurements at the NPI and future plans in SPIRAL2/NFS

Science.gov (United States)

Šimečková, Eva; Bém, Pavel; Mrázek, Jaromír; Štefánik, Milan; Běhal, Radomír; Gladolev, Vadim

2017-09-01

The proton- and deuteron-induced reactions are of a great interest for the assessment of induced radioactivity of accelerator components, target and beam stoppers as well as isotope production for medicine. In the present work, the deuteron-induced reaction cross sections on zinc were investigated by stacked-foil activation technique with deuteron beam of 20 MeV energy from the cyclotron U-120M of NPI CAS Řež. Also the proton activation cross section measurement of iron is presented. The comparison of present results to data of other authors and to predictions of evaluated data libraries is discussed. The investigation shall continue for higher proton and deuteron energy interval 20-35 MeV at SPIRAL2/NFS facility using a charged particle irradiation chamber with pneumatic transport system to measure isotopes and isomers with half-lives in minutes-regions.

Alteration of NPY and Y1 receptor in dorsomedial and ventromedial areas of hypothalamus in anorectic tumor-bearing rats.

Science.gov (United States)

Chance, William T; Xiao, Chun; Dayal, Ramesh; Sheriff, Sulaiman

2007-02-01

Although previous studies have implicated NPY in the etiology of experimental cancer anorexia, the results have been difficult to interpret. Studies have suggested that although NPY level and message were decreased in the dorsomedial hypothalamic area (DMA), they were elevated in the ventromedial hypothalamic area (VMA). To better assess specific intra-area alterations of NPY, Y(1) receptor (Y(1) R), and agouti-related peptide (AgRP) in TB rats, we used radioimmunoassay, quantitative real-time RT-PCR, and immunohistochemistry. We found that NPY and AgRP mRNA were elevated significantly in whole hypothalamus of anorectic TB rats, while Y(1) R mRNA was decreased. Based on two replicates of four pooled samples each, both NPY and AgRP mRNA appeared to be elevated in the VMA of anorectic TB rats, while only AgRP exhibited a similar increase in the DMA. Levels of NPY were elevated in the VMA of both TB and pair-fed (PF) rats, but in the DMA only PF rats exhibited a significant NPY increase. NPY and Y(1) R immunohistochemistry revealed reduced NPY staining in PVN and ARC nucleus of TB and PF rats. Y(1) R immunostaining was also reduced in the ARC and PVN of TB rats, while PF rats exhibited elevated immunostaining in the PVN. These results continue to implicate dysfunction of NPY feeding systems in experimental cancer anorexia and suggest down-regulation of Y(1) R receptors as well as possible problems in NPY translation.

Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novel NPY-cleaving peptidases and potential drug interactions in CNS and Periphery.

Science.gov (United States)

Wagner, Leona; Wolf, Raik; Zeitschel, Ulrike; Rossner, Steffen; Petersén, Åsa; Leavitt, Blair R; Kästner, Florian; Rothermundt, Matthias; Gärtner, Ulf-Torsten; Gündel, Daniel; Schlenzig, Dagmar; Frerker, Nadine; Schade, Jutta; Manhart, Susanne; Rahfeld, Jens-Ulrich; Demuth, Hans-Ulrich; von Hörsten, Stephan

2015-12-01

The bioactivity of neuropeptide Y (NPY) is either N-terminally modulated with respect to receptor selectivity by dipeptidyl peptidase 4 (DP4)-like enzymes or proteolytic degraded by neprilysin or meprins, thereby abrogating signal transduction. However, neither the subcellular nor the compartmental differentiation of these regulatory mechanisms is fully understood. Using mass spectrometry, selective inhibitors and histochemistry, studies across various cell types, body fluids, and tissues revealed that most frequently DP4-like enzymes, aminopeptidases P, secreted meprin-A (Mep-A), and cathepsin D (CTSD) rapidly hydrolyze NPY, depending on the cell type and tissue under study. Novel degradation of NPY by cathepsins B, D, L, G, S, and tissue kallikrein could also be identified. The expression of DP4, CTSD, and Mep-A at the median eminence indicates that the bioactivity of NPY is regulated by peptidases at the interphase between the periphery and the CNS. Detailed ex vivo studies on human sera and CSF samples recognized CTSD as the major NPY-cleaving enzyme in the CSF, whereas an additional C-terminal truncation by angiotensin-converting enzyme could be detected in serum. The latter finding hints to potential drug interaction between antidiabetic DP4 inhibitors and anti-hypertensive angiotensin-converting enzyme inhibitors, while it ablates suspected hypertensive side effects of only antidiabetic DP4-inhibitors application. The bioactivity of neuropeptide Y (NPY) is either N-terminally modulated with respect to receptor selectivity by dipeptidyl peptidase 4 (DP4)-like enzymes or proteolytic degraded by neprilysin or meprins, thereby abrogating signal transduction. However, neither the subcellular nor the compartmental differentiation of these regulatory mechanisms is fully understood. Using mass spectrometry, selective inhibitors and histochemistry, studies across various cell types, body fluids, and tissues revealed that most frequently DP4-like enzymes

Neuropeptide Y deficiency attenuates responses to fasting and high-fat diet in obesity-prone mice.

Science.gov (United States)

Patel, Hiralben R; Qi, Yong; Hawkins, Evan J; Hileman, Stanley M; Elmquist, Joel K; Imai, Yumi; Ahima, Rexford S

2006-11-01

Neuropeptide Y (NPY) stimulates feeding and weight gain, but deletion of the NPY gene does not affect food intake and body weight in mice bred on a mixed genetic background. We reasoned that the orexigenic action of NPY would be evident in C57Bl/6J mice susceptible to obesity. NPY deficiency has no significant effect in mice fed a normal rodent diet. However, energy expenditure is elevated during fasting, and hyperphagia and weight gain are blunted during refeeding. Expression of agouti-related peptide (AGRP) in the hypothalamus is increased in NPY knockout (NPYko) than wild-type mice, but unlike wild type there is no further increase in AGRP when NPYko mice are fasted. Moreover, NPYko mice have higher oxygen consumption and uncoupling protein-1 expression in brown adipose tissue during fasting. The failure of an increase in orexigenic peptides and higher thermogenesis may contribute to attenuation of weight gain when NPYko mice are refed. C57Bl/6J mice lacking NPY are also less susceptible to diet-induced obesity (DIO) as a result of reduced feeding and increased energy expenditure. The resistance to DIO in NPYko mice is associated with a reduction in nocturnal feeding and increased expression of anorexigenic hypothalamic peptides. Insulin, leptin, and triglyceride levels increase with adiposity in both wild-type and NPYko mice.

Fast wave heating experiments in the ion cyclotron range of frequencies on ATF

Energy Technology Data Exchange (ETDEWEB)

Kwon, M; Shepard, T D; Goulding, R H [Oak Ridge National Lab., TN (United States); and others

1992-07-01

Fast wave heating experiments in the ion cyclotron range of frequencies (ICRF) were performed on target plasmas produced by 350 kW of electron cyclotron heating at 53 GHz and also by neutral beam injection in the Advanced Toroidal Facility (ATF). Various heating regimes were investigated in the frequency range between 9.2 MHz and 28.8 MHz with magnetic fields of 0.95 T and 1.9 T on axis. The nominal pulse lengths of up to 200 kW RF power were in the range between 100 and 400 ms. Data from spectroscopy, loading measurements, and edge RF and Langmuir probes were used to characterize the RF induced effects on the ATF plasma. In the hydrogen minority regime at low plasma density, large suprathermal ion tails were observed with a neutral particle analyser. At high density (n-bar{sub e} {>=} 5.0 x 10{sup 13} cm{sup -3}) substantial increases in antenna loading were observed, but ICRF power was insufficient to produce definitive heating results. A two-dimensional RF heating code, ORION, and a Fokker-Planck code, RFTRANS, were used to simulate these experiments. A simulation of future high power, higher density experiments in ATF indicates improved bulk heating results due to the improved loading and more efficient thermalization of the minority tail. (author). 29 refs, 16 figs, 3 tabs.

Measurements of the fast ion distribution during neutral beam injection and ion cyclotron heating in ATF [Advanced Toroidal Facility

International Nuclear Information System (INIS)

Wade, M.R.; Kwon, M.; Thomas, C.E.; Colchin, R.J.; England, A.C.; Gossett, J.M.; Horton, L.D.; Isler, R.C.; Lyon, J.F.; Rasmussen, D.A.; Rayburn, T.M.; Shepard, T.D.; Bell, G.L.; Fowler, R.H.; Morris, R.N.

1990-01-01

A neutral particle analyzer (NPA) with horizontal and vertical scanning capability has been used to make initial measurements of the fast ion distribution during neutral beam injection (NBI) and ion cyclotron heating (ICH) on the Advanced Toroidal Facility (ATF). These measurements are presented and compared with the results of modeling codes that predict the analyzer signals during these heating processes. 6 refs., 5 figs

Genetic modulation of plasma NPY stress response is suppressed in substance abuse: association with clinical outcomes.

Science.gov (United States)

Xu, Ke; Hong, Kwangik Adam; Zhou, Zhifeng; Hauger, Richard L; Goldman, David; Sinha, Rajita

2012-04-01

Neuropeptide Y (NPY) is involved in stress regulation. Genetic variations predict plasma NPY and neural correlates of emotion and stress. We examined whether the functional NPY haplotype modulates stress-induced NPY and anxiety responses, and if plasma NPY stress responses are associated with substance dependence outcomes. Thirty-seven treatment-engaged, abstinent substance dependent (SD) patients and 28 healthy controls (HCs) characterized on NPY diplotypes (HH: high expression; HLLL: intermediate/low expression) were exposed to stress, alcohol/drug cues and neutral relaxing cues, using individualized guided imagery, in a 3-session laboratory experiment. Plasma NPY, heart rate and anxiety were assessed. Patients were prospectively followed for 90-days post-treatment to assess relapse outcomes. HH individuals showed significantly lower stress-induced NPY with greater heart rate and anxiety ratings, while the HLLL group showed the reverse pattern of NPY, anxiety and heart rate responses. This differential genetic modulation of NPY stress response was suppressed in the SD group, who showed no stress-related increases in NPY and higher heart rate and greater anxiety, regardless of diplotype. Lower NPY predicted subsequent higher number of days and greater amounts of post-treatment drug use. These preliminary findings are the first to document chronic drug abuse influences on NPY diplotype expression where NPY diplotype modulation of stress-related plasma NPY, heart rate and anxiety responses was absent in the substance abuse sample. The finding that lower stress-related NPY is predictive of greater relapse severity provides support for therapeutic development of neuropeptide Y targets in the treatment of substance use disorders. Copyright © 2011 Elsevier Ltd. All rights reserved.

Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP.

Science.gov (United States)

Krashes, Michael J; Shah, Bhavik P; Koda, Shuichi; Lowell, Bradford B

2013-10-01

Agouti-related peptide (AgRP) neurons of the hypothalamus release a fast transmitter (GABA) in addition to neuropeptides (neuropeptide Y [NPY] and Agouti-related peptide [AgRP]). This raises questions as to their respective functions. The acute activation of AgRP neurons robustly promotes food intake, while central injections of AgRP, NPY, or GABA agonist results in the marked escalation of food consumption with temporal variance. Given the orexigenic capability of all three of these neuroactive substances in conjunction with their coexpression in AgRP neurons, we looked to unravel their relative temporal role in driving food intake. After the acute stimulation of AgRP neurons with DREADD technology, we found that either GABA or NPY is required for the rapid stimulation of feeding, and the neuropeptide AgRP, through action on MC4 receptors, is sufficient to induce feeding over a delayed yet prolonged period. These studies help to elucidate the neurochemical mechanisms of AgRP neurons in controlling temporally distinct phases of eating. Copyright © 2013 Elsevier Inc. All rights reserved.

Modeling of neutron emission spectroscopy in JET discharges with fast tritons from (T)D ion cyclotron heating

International Nuclear Information System (INIS)

Tardocchi, M.; Gorini, G.; Andersson Sunden, E.; Conroy, S.; Ericsson, G.; Gatu Johnson, M.; Giacomelli, L.; Hellesen, C.; Hjalmarsson, A.; Kaellne, J.; Ronchi, E.; Sjoestrand, H.; Weiszflog, M.; Johnson, T.; Lamalle, P. U.

2006-01-01

The measurement of fast ion populations is one of the diagnostic capabilities provided by neutron emission spectroscopy (NES). NES measurements were carried out during JET trace tritium campaign with the magnetic proton recoil neutron spectrometer. A favorable plasma scenario is (T)D where the resulting 14 MeV neutron yield is dominated by suprathermal emission from energetic tritons accelerated by radio frequency at their fundamental cyclotron frequency. Information on the triton distribution function has been derived from NES data with a simple model based on two components referred to as bulk (B) and high energy (HE). The HE component is based on strongly anisotropic tritium distribution that can be used for routine best-fit analysis to provide tail temperature values (T HE ). This article addresses to what extent the T HE values are model dependent by comparing the model above with a two-temperature (bi-) Maxwellian model featuring parallel and perpendicular temperatures. The bi-Maxwellian model is strongly anisotropic and frequently used for radio frequency theory

NPY2-receptor variation modulates iconic memory processes.

Science.gov (United States)

Arning, Larissa; Stock, Ann-Kathrin; Kloster, Eugen; Epplen, Jörg T; Beste, Christian

2014-08-01

Sensory memory systems are modality-specific buffers that comprise information about external stimuli, which represent the earliest stage of information processing. While these systems have been the subject of cognitive neuroscience research for decades, little is known about the neurobiological basis of sensory memory. However, accumulating evidence suggests that the glutamatergic system and systems influencing glutamatergic neural transmission are important. In the current study we examine if functional promoter variations in neuropeptide Y (NPY) and its receptor gene NPY2R affect iconic memory processes using a partial report paradigm. We found that iconic memory decayed much faster in individuals carrying the rare promoter NPY2R G allele which is associated with increased expression of the Y2 receptor. Possibly this effect is due to altered presynaptic inhibition of glutamate release, known to be modulated by Y2 receptors. Altogether, our results provide evidence that the functionally relevant single nucleotide polymorphism (SNP) in the NPY2R promoter gene affect circumscribed processes of early sensory processing, i.e. only the stability of information in sensory memory buffers. This leads us to suggest that especially the stability of information in sensory memory buffers depends on glutamatergic neural transmission and factors modulating glutamatergic turnover. Copyright © 2014 Elsevier B.V. and ECNP. All rights reserved.

Feed intake and brain neuropeptide Y (NPY) and cholecystokinin (CCK) gene expression in juvenile cobia fed plant-based protein diets with different lysine to arginine ratios.

Science.gov (United States)

Nguyen, Minh Van; Jordal, Ann-Elise Olderbakk; Espe, Marit; Buttle, Louise; Lai, Hung Van; Rønnestad, Ivar

2013-07-01

Cobia (Rachycentron canadum, Actinopterygii, Perciformes;10.5±0.1g) were fed to satiation with three plant-based protein test diets with different lysine (L) to arginine (A) ratios (LL/A, 0.8; BL/A, 1.1; and HL/A, 1.8), using a commercial diet as control for six weeks. The test diets contained 730 g kg(-1) plant ingredients with 505-529 g protein, 90.2-93.9 g lipid kg(-1) dry matter; control diet contained 550 g protein and 95 g lipid kg(-1) dry matter. Periprandial expression of brain NPY and CCK (npy and cck) was measured twice (weeks 1 and 6). At week one, npy levels were higher in pre-feeding than postfeeding cobia for all diets, except LL/A. At week six, npy levels in pre-feeding were higher than in postfeeding cobia for all diets. cck in pre-feeding cobia did not differ from that in postfeeding for all diets, at either time point. Cobia fed LL/A had lower feed intake (FI) than cobia fed BL/A and control diet, but no clear correlations between dietary L/A ratio and FI, growth and expression of npy and cck were detected. The data suggest that NPY serves as an orexigenic factor, but further studies are necessary to describe links between dietary L/A and regulation of appetite and FI in cobia. Copyright © 2013 Elsevier Inc. All rights reserved.

Diet-induced obesity attenuates fasting-induced hyperphagia.

Science.gov (United States)

Briggs, D I; Lemus, M B; Kua, E; Andrews, Z B

2011-07-01

Obesity impairs arcuate (ARC) neuropeptide Y (NPY)/agouti-releated peptide (AgRP) neuronal function and renders these homeostatic neurones unresponsive to the orexigenic hormone ghrelin. In the present study, we investigated the effect of diet-induced obesity (DIO) on feeding behaviour, ARC neuronal activation and mRNA expression following another orexigenic stimulus, an overnight fast. We show that 9 weeks of high-fat feeding attenuates fasting-induced hyperphagia by suppressing ARC neuronal activation and hypothalamic NPY/AgRP mRNA expression. Thus, the lack of appropriate feeding responses in DIO mice to a fast is caused by failure ARC neurones to recognise and/or respond to orexigenic cues. We propose that fasting-induced hyperphagia is regulated not by homeostatic control of appetite in DIO mice, but rather by changes in the reward circuitry. © 2011 The Authors. Journal of Neuroendocrinology © 2011 Blackwell Publishing Ltd.

Slow wave cyclotron maser

International Nuclear Information System (INIS)

Kho, T.H.; Lin, A.T.

1988-01-01

Cyclotron masers such as Gyrotrons and the Autoresonance Masers, are fast wave devices: the electromagnetic wave's phase velocity v rho , is greater than the electron beam velocity, v b . To be able to convert the beam kinetic energy into radiation in these devices the beam must have an initial transverse momentum, usually obtained by propagating the beam through a transverse wiggler magnet, or along a nonuniform guide magnetic field before entry into the interaction region. Either process introduces a significant amount of thermal spread in the beam which degrades the performance of the maser. However, if the wave phase velocity v rho v b , the beam kinetic energy can be converted directly into radiation without the requirement of an initial transverse beam momentum, making a slow wave cyclotron maser a potentially simpler and more compact device. The authors present the linear and nonlinear physics of the slow wave cyclotron maser and examine its potential for practical application

Decontamination of the activation product based on a legal revision of the cyclotron vault room on the non-self-shield compact medical cyclotron

International Nuclear Information System (INIS)

Komiya, Isao; Umezu, Yoshiyuki; Fujibuchi, Toshiou; Nakamura, Kazumasa; Baba, Shingo; Honda, Hiroshi

2016-01-01

The non-self-shield compact medical cyclotron and the cyclotron vault room were in operation for 27 years. They have now been decommissioned. We efficiently implemented a technique to identify an activation product in the cyclotron vault room. Firstly, the distribution of radioactive concentrations in the concrete of the cyclotron vault room was estimated by calculation from the record of the cyclotron operation. Secondly, the comparison of calculated results with an actual measurement was performed using a NaI scintillation survey meter and a high-purity germanium detector. The calculated values were overestimated as compared to the values measured using the Nal scintillation survey meter and the high-purity germanium detector. However, it could limit the decontamination area. By simulating the activation range, we were able to minimize the concrete core sampling. Finally, the appropriate range of radioactivated area in the cyclotron vault room was decontaminated based on the results of the calculation. After decontamination, the radioactive concentration was below the detection limit value in all areas inside the cyclotron vault room. By these procedures, the decommissioning process of the cyclotron vault room was more efficiently performed. (author)

Utility of the Neuropsychiatric Inventory Questionnaire (NPI-Q in the assessment of a sample of patients with Alzheimer's disease in Chile

Directory of Open Access Journals (Sweden)

Gada Musa

Full Text Available ABSTRACT The Neuropsychiatric Inventory Questionnaire (NPI-Q is an informant-based instrument that measures the presence and severity of 12 Neuropsychiatric Symptoms (NPS in patients with dementia, as well as informant distress. Objective: To measure the psychometric properties of the NPI-Q and the prevalence of NPS in patients with Alzheimer's disease (AD in Chile. Methods: 53 patients with AD were assessed. Subjects were divided into two different groups: mild AD (n=26 and moderate AD (n=27. Convergent validity was estimated by correlating the outcomes of the NPI-Q with Neuropsychiatric Inventory (NPI scores and with a global cognitive efficiency test (Addenbrooke's Cognitive Examination - Revised - ACE-R. Reliability of the NPI-Q was analysed by calculating its internal consistency. Prevalence of NPS was estimated with both the NPI and NPI-Q. Results: Positive and significant correlations were observed between the NPI-Q, the NPI, and the ACE-R (r=0.730; p<0.01 and 0.315; p<0.05 respectively. The instrument displayed an adequate level of reliability (Cronbach's alpha=0.783. The most prevalent NPS were apathy/indifference (62.3% and dysphoria/depression (58.5%. Conclusion: The NPI-Q exhibited acceptable validity and reliability indicators for patients with AD in Chile, indicating that it is a suitable instrument for the routine assessment of NPS in clinical practice.

Health physics aspects of the 1.5M cyclotron

International Nuclear Information System (INIS)

Song, W.J.; Du, H.L.; Wei, Z.Q.; Xia, X.S.; Zheng, H.Z.; Jiang, G.F.; Liu, Y.Y.

1987-01-01

The 1.5m cyclotron in Institute of Modern Physics, Academia Sinica had operated for about 20 years until 1984 then converted to 1.7m sector focusing cyclotron. In this period it mainly used for fast neutron physics, light ion induced nucleus reactions, radioisotope production and heavy ion reactions. The health physics performed on this cyclotron including personnel dose monitoring, area monitoring (radiation field, radioactive aerosol, surface contamination and activated components etc.), maintenance inspection, environment survey and waste disposal is presented in this paper

Central and peripheral mechanisms of the NPY system in the regulation of bone and adipose tissue.

Science.gov (United States)

Shi, Yan-Chuan; Baldock, Paul A

2012-02-01

Skeletal research is currently undergoing a period of marked expansion. The boundaries of "bone" research are being re-evaluated and with this, a growing recognition of a more complex and interconnected biology than previously considered. One aspect that has become the focus of particular attention is the relationship between bone and fat homeostasis. Evidence from a number of avenues indicates that bone and adipose regulation are both related and interdependent. This review examines the neuropeptide Y (NPY) system, known to exert powerful control over both bone and fat tissue. The actions of this system are characterized by signaling both within specific nuclei of the hypothalamus and also the target tissues, mediated predominantly through two G-protein coupled receptors (Y1 and Y2). In bone tissue, elevated NPY levels act consistently to repress osteoblast activity. Moreover, both central Y2 receptor and osteoblastic Y1 receptor signaling act similarly to repress bone formation. Conversely, loss of NPY expression or receptor signaling induces increased osteoblast activity and bone mass in both cortical and cancellous envelopes. In fat tissue, NPY action is more complex. Energy homeostasis is powerfully altered by elevations in hypothalamic NPY, resulting in increases in fat accretion and body-wide energy conservation, through the action of locally expressed Y1 receptors, while local Y2 receptors act to inhibit NPY-ergic tone. Loss of central NPY expression has a markedly reduced effect, consistent with a physiological drive to promote fat accretion. In fat tissue, NPY and Y1 receptors act to promote lipogenesis, consistent with their roles in the brain. Y2 receptors expressed in adipocytes also act in this manner, showing an opposing action to their role in the hypothalamus. While direct investigation of these processes has yet to be completed, these responses appear to be interrelated to some degree. The starvation-based signal of elevated central NPY inducing

Short-Term Prognostic Index for Breast Cancer: NPI or Lpi

Directory of Open Access Journals (Sweden)

V. Van Belle

2011-01-01

Full Text Available Axillary lymph node involvement is an important prognostic factor for breast cancer survival but is confounded by the number of nodes examined. We compare the performance of the log odds prognostic index (Lpi, using a ratio of the positive versus negative lymph nodes, with the Nottingham Prognostic Index (NPI for short-term breast cancer specific disease free survival. A total of 1818 operable breast cancer patients treated in the University Hospital of Leuven between 2000 and 2005 were included. The performance of the NPI and Lpi were compared on two levels: calibration and discrimination. The latter was evaluated using the concordance index (cindex, the number of patients in the extreme groups, and difference in event rates between these. The NPI had a significant higher cindex, but a significant lower percentage of patients in the extreme risk groups. After updating both indices, no significant differences between NPI and Lpi were noted.

Induction of mutations in antibiotic-producing microorganisms by fast neutrons from the U-120 cyclotron

International Nuclear Information System (INIS)

Wolf, J.; Huczkowski, J.; Siejka, D.; Krasnowolski, S.; Brodowicz, M.

1976-01-01

The purpose of this study was to investigate the activity of fast neutrons from a U-120 cyclotron in the induction of mutations in streptomycetes, resulting in strains with enhanced antibiotic production. Three streptomycete strains producing the antibiotics: lincomycin, moenomycin, and demethylchlorotetracycline were used. Correlation between the survival rate of spores of the examined strains and neutron dose was determined. Several morphological and physiological features (particularly production of antibiotics for 1543 variants derived from the parent strains) and their distribution within the population were also studied. The survival rate of the streptomycetes spores after irradiation with fast neutrons was found to be an individual strain property. Several variants with considerably increased antibiotic yield were isolated. The results are compared with those obtained after treatment with other mutagens. Several variants of one of the strains with a strongly enhanced antibiotic yield (200-220%) were isolated. No such variants were found after UV irradiation. (author)

Potential of cyclotron based accelerators for energy production and transmutation

Energy Technology Data Exchange (ETDEWEB)

Stammbach, T.; Adam, S.; Fitze, H.R. [Paul Scherrer Institute, Villigen (Switzerland)] [and others

1995-10-01

PSI operates a 590 MeV-cyclotron facility for high intensity proton beams for the production of intense beams of pions and muons. The facility, commissioned in 1974, has been partially upgraded and is now operated routinely at a beam current of 1 mA, which corresponds to a beam power of 0.6 MW. At this current, the beam losses in the cyclotron are about 0.02%. By the end of 1995 the authors expect to have 1.5 mA of protons. Extensive theoretical investigations on beam current limitations in isochronous cyclotrons were undertaken. They show that the longitudinal space charge effects dominate. Based on their experience the authors present a preliminary design of a cyclotron scheme that could produce a 10 MW beam as a driver for an {open_quotes}energy amplifier{close_quotes} as proposed by C. Rubbia and his collaborators. The expected efficiency for the conversion of AC into beam power would be about 50% (for the RF-systems only). The beam losses in the cyclotron are expected to be a few {mu}A, leading to a tolerable activation level.

Pancreatic polypeptide controls energy homeostasis via Npy6r signaling in the suprachiasmatic nucleus in mice.

Science.gov (United States)

Yulyaningsih, Ernie; Loh, Kim; Lin, Shu; Lau, Jackie; Zhang, Lei; Shi, Yanchuan; Berning, Britt A; Enriquez, Ronaldo; Driessler, Frank; Macia, Laurence; Khor, Ee Cheng; Qi, Yue; Baldock, Paul; Sainsbury, Amanda; Herzog, Herbert

2014-01-07

Y-receptors control energy homeostasis, but the role of Npy6 receptors (Npy6r) is largely unknown. Young Npy6r-deficient (Npy6r(-/-)) mice have reduced body weight, lean mass, and adiposity, while older and high-fat-fed Npy6r(-/-) mice have low lean mass with increased adiposity. Npy6r(-/-) mice showed reduced hypothalamic growth hormone releasing hormone (Ghrh) expression and serum insulin-like growth factor-1 (IGF-1) levels relative to WT. This is likely due to impaired vasoactive intestinal peptide (VIP) signaling in the suprachiasmatic nucleus (SCN), where we found Npy6r coexpressed in VIP neurons. Peripheral administration of pancreatic polypeptide (PP) increased Fos expression in the SCN, increased energy expenditure, and reduced food intake in WT, but not Npy6r(-/-), mice. Moreover, intraperitoneal (i.p.) PP injection increased hypothalamic Ghrh mRNA expression and serum IGF-1 levels in WT, but not Npy6r(-/-), mice, an effect blocked by intracerebroventricular (i.c.v.) Vasoactive Intestinal Peptide (VPAC) receptors antagonism. Thus, PP-initiated signaling through Npy6r in VIP neurons regulates the growth hormone axis and body composition. Copyright © 2014 Elsevier Inc. All rights reserved.

[Cyclotron based nuclear science

International Nuclear Information System (INIS)

1989-06-01

This report contains papers on the following topics: Heavy ion reactors, nuclear structure and fundamental interactions; atomic and materials studies; nuclear theory; and superconducting cyclotron and instrumentation

New superconducting cyclotron driven scanning proton therapy systems

International Nuclear Information System (INIS)

Klein, Hans-Udo; Baumgarten, Christian; Geisler, Andreas; Heese, Juergen; Hobl, Achim; Krischel, Detlef; Schillo, Michael; Schmidt, Stefan; Timmer, Jan

2005-01-01

Since one and a half decades ACCEL is investing in development and engineering of state of the art particle-therapy systems. A new medical superconducting 250 MeV proton cyclotron with special focus on the present and future beam requirements of fast scanning treatment systems has been designed. The first new ACCEL medical proton cyclotron is under commissioning at PSI for their PROSCAN proton therapy facility having undergone successful factory tests especially of the closed loop cryomagnetic system. The second cyclotron is part of ACCEL's integrated proton therapy system for Europe's first clinical center, RPTC in Munich. The cyclotron, the energy selection system, the beamline as well as the four gantries and patient positioners have been installed. The scanning system and major parts of the control software have already been tested. We will report on the concept of ACCEL's superconducting cyclotron driven scanning proton therapy systems and the current status of the commissioning work at PSI and RPTC

Support vector machine based fault detection approach for RFT-30 cyclotron

Energy Technology Data Exchange (ETDEWEB)

Kong, Young Bae, E-mail: ybkong@kaeri.re.kr; Lee, Eun Je; Hur, Min Goo; Park, Jeong Hoon; Park, Yong Dae; Yang, Seung Dae

2016-10-21

An RFT-30 is a 30 MeV cyclotron used for radioisotope applications and radiopharmaceutical researches. The RFT-30 cyclotron is highly complex and includes many signals for control and monitoring of the system. It is quite difficult to detect and monitor the system failure in real time. Moreover, continuous monitoring of the system is hard and time-consuming work for human operators. In this paper, we propose a support vector machine (SVM) based fault detection approach for the RFT-30 cyclotron. The proposed approach performs SVM learning with training samples to construct the classification model. To compensate the system complexity due to the large-scale accelerator, we utilize the principal component analysis (PCA) for transformation of the original data. After training procedure, the proposed approach detects the system faults in real time. We analyzed the performance of the proposed approach utilizing the experimental data of the RFT-30 cyclotron. The performance results show that the proposed SVM approach can provide an efficient way to control the cyclotron system.

Effect of Maluoning treatment on serum content of NPY in patients with COPD

International Nuclear Information System (INIS)

Wu Minghui; Jiang Anlai; Song Hedi

2011-01-01

Objective: To study the effect of maluoning treatment on serum NPY contents in patients with COPD. Methods: To COPD patients were divided into two groups: treatment group (n=40), control groups (n=30). Serum NPY contents were determined in two groups patients at 1d-3d before admission and one year later respectively. Results: The serum NPY level in two groups of COPD patients were not much different at admission(89.4±15.2) pg/ml vs (90.5±15.6) pg/ml (P>0.05). Serum NPY contents in 40 patients with Maluoning treatment after one year were apparently lower than those in the 30 patients without Maluoning treatment (72.9±13.8) pg/ml vs (81.8±14.6) pg/ml (P<0.05). Conclusion: Maluoning could markedly reduce the serum NPY content in patients with COPD. (authors)

Cross-cultural invariance of NPI-13: Entitlement as culturally specific, leadership and grandiosity as culturally universal.

Science.gov (United States)

Żemojtel-Piotrowska, Magdalena; Piotrowski, Jarosław; Rogoza, Radosław; Baran, Tomasz; Hitokoto, Hidefumi; Maltby, John

2018-04-15

The current study explores the problem with the lack of measurement invariance for the Narcissistic Personality Inventory (NPI) by addressing two issues: conceptual heterogeneity of narcissism and methodological issues related to the binary character of data. We examine the measurement invariance of the 13-item version of the NPI in three populations in Japan, Poland and the UK. Analyses revealed that leadership/authority and grandiose exhibitionism dimensions of the NPI were cross-culturally invariant, while entitlement/exploitativeness was culturally specific. Therefore, we proposed NPI-9 as indicating scalar invariance, and we examined the pattern of correlations between NPI-9 and other variables across three countries. The results suggest that NPI-9 is valid brief scale measuring general levels of narcissism in cross-cultural studies, while the NPI-13 remains suitable for research within specific countries. © 2018 International Union of Psychological Science.

Clinical study on the changes of plasma Hcy, β2-m, cortisol, NPY levels and NPY contents in CSF in patients with acute traumatic intracranial hemorrhage as well as patients with cerebral infarction

International Nuclear Information System (INIS)

Ruan Wenhua; Yang Yongqing

2007-01-01

Objective: To invest/gate the clinical significance of the changes of plasma Hcy, β 2 -m, cortisol, NPY levels and NPY contents in CSF in patients with acute traumatic intracranial hemorrhage as well as patients with cerebral infarction. Methods: Plasma β 2 -m, cortisol, NPY, NPY in CSF (with RIA) and plasma Hey (with CLIA ) contents were measured in 68 patients with acute traumatic intracranial haemorrhage (mild 33, severe 35) as well as 39 patients with cerebral infarction (plus 35 controls). Results: The plasma β 2 -m, Hcy and 8h, 24h cortisol levels in all these patients were significantly higher than those in controls (P 2 -m, Hcy, cortisol levels and NPY contents in CSF were very prominent in all these patients studied. (authors)

Interaction between neuropeptide Y (NPY) and brain-derived neurotrophic factor in NPY-mediated neuroprotection against excitotoxicity

DEFF Research Database (Denmark)

Xapelli, S; Bernardino, L; Ferreira, R

2008-01-01

The neuroprotective effect of neuropeptide Y (NPY) receptor activation was investigated in organotypic mouse hippocampal slice cultures exposed to the glutamate receptor agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA). Exposure of 2-week-old slice cultures, derived from 7-...

Novel role of NPY in neuroimmune interaction and lung growth after intrauterine growth restriction.

Science.gov (United States)

Thangaratnarajah, Chansutha; Dinger, Katharina; Vohlen, Christina; Klaudt, Christian; Nawabi, Jawed; Lopez Garcia, Eva; Kwapiszewska, Grazyna; Dobner, Julia; Nüsken, Kai D; van Koningsbruggen-Rietschel, Silke; von Hörsten, Stephan; Dötsch, Jörg; Alejandre Alcázar, Miguel A

2017-09-01

Individuals with intrauterine growth restriction (IUGR) are at risk for chronic lung disease. Using a rat model, we showed in our previous studies that altered lung structure is related to IL-6/STAT3 signaling. As neuropeptide Y (NPY), a coneurotransmitter of the sympathetic nervous system, regulates proliferation and immune response, we hypothesized that dysregulated NPY after IUGR is linked to IL-6, impaired myofibroblast function, and alveolar growth. IUGR was induced in rats by isocaloric low-protein diet; lungs were analyzed on embryonic day (E) 21, postnatal day (P) 3, P12, and P23. Finally, primary neonatal lung myofibroblasts (pnF) and murine embryonic fibroblasts (MEF) were used to assess proliferation, apoptosis, migration, and IL-6 expression. At E21, NPY and IL-6 expression was decreased, and AKT/PKC and STAT3/AMPKα signaling was reduced. Early reduction of NPY/IL-6 was associated with increased chord length in lungs after IUGR at P3, indicating reduced alveolar formation. At P23, however, IUGR rats exhibited a catch-up of body weight and alveolar growth coupled with more proliferating myofibroblasts. These structural findings after IUGR were linked to activated NPY/PKC, IL-6/AMPKα signaling. Complementary, IUGR-pnF showed increased survival, impaired migration, and reduced IL-6 compared with control-pnF (Co-pnF). In contrast, NPY induced proliferation, migration, and increased IL-6 synthesis in fibroblasts. Additionally, NPY -/- mice showed reduced IL-6 signaling and less proliferation of lung fibroblasts. Our study presents a novel role of NPY during alveolarization: NPY regulates 1 ) IL-6 and lung STAT3/AMPKα signaling, and 2 ) proliferation and migration of myofibroblasts. These new insights in pulmonary neuroimmune interaction offer potential strategies to enable lung growth. Copyright © 2017 the American Physiological Society.

The Stimulatory Effect of Cerebral Intraventricular Injection of cNPY on Precocial Feeding Behavior in Neonatal Chicks (Gallus domesticus.

Directory of Open Access Journals (Sweden)

Guiqian Chen

Full Text Available Neuropeptide Y (NPY is one of the most potent stimulants of food intake in many animals. Most of the supporting evidence for the effects of NPY has been gathered in mammalian species using porcine NPY. To investigate the effects of NPY on precocial feeding initiation in chicks, we firstly used chicken NPY (cNPY to study its role in food intake and spontaneous activities in 3-day-old male chicks. Food intake was monitored at different times after intracerebroventricular (ICV injection of cNPY (2.5, 5.0 or 10.0 μg/10 μL and anti-cNPY antibody (anti-cNPY (1:9000, 1:3000 or 1:1000 in dilution. cNPY given at different doses significantly increased food intake at 30 min, 60 min, 90 min and 120 min after injection. Chicks treated with 5.0 μg/10 μL of cNPY showed a maximal 4.48 fold increase in food intake comparing to the control at 30 min. There is still more than 2 fold increase in food intake at 120 min after injection of cNPY. Food intake was significantly inhibited by a single ICV injection of anti-cNPY diluted to 1:9000 (60% inhibition, 1:3000 (92% inhibition, and 1:1000 (95% inhibition at 30 min with 1:1000 being the maximally effective concentration. The inhibitory effects of anti-cNPY (diluted to1:9000, 1:3000, 1:1000 at 120 min post ICV injection were 22%, 42% and 46%, respectively. But ICV of anti-cNPY (1:3000 in dilution did not block the orexigenic effect of 2.5 μg/10 μL of cNPY. ICV injection of different concentrations of cNPY increases locomotor activity in a dose-dependent manner while ICV anti-cNPY greatly decreased the distance moved by each chick compared to control groups. Taken together, our results demonstrated that cNPY has a promoting effect on chick food intake and locomotor activity, and that endogenous cNPY might play a positive role in regulating precocial feeding behavior in newly hatched chicks.

Studies on fast wave current drive in the JAERI tokamaks

International Nuclear Information System (INIS)

Kimura, H.; Yamamoto, T.; Fujii, T.; Kawashima, H.; Tamai, H.; Saigusa, M.; Imai, T.; Hamamatsu, K.; Fukuyama, A.

1991-01-01

Fast wave electron heating experiment (FWEH) on JFT-2M and JT-60 and analysis of fast wave current drive (FWCD) ability on JT-60U are presented. In the JFT-2M, absorption of fast waves have been investigated by using a phased four-loop antenna array. The absorption of the fast waves has been studied for various plasma parameters by using combination of other additional heating methods such as electron cyclotron heating (ECH) and ion cyclotron heating. It is shown that the absorption efficiency estimated from various methods well correlates with one calculated theoretically in single pass damping. Interaction of the fast waves with fast electrons in combination with ECH has been examined through the measurement of non-thermal electron cyclotron emission (ECE). The observed ECE during FWEH is well explained by the theoretical model, which indicates generation of the appreciable energetic fast electrons by the fast waves. New four-loop array antennas have been employed to improve the absorption of unidirectionally-propagating waves. Characteristics of antenna loading resistance can be reproduced by a coupling calculation code. In JT-60, FWEH experiment in combination with lower hybrid current drive was performed. Power absorption efficiency of fast wave is substantially improved in combination with LHCD of relatively low power for both phasing modes. Bulk electron heating is observed with high-k // mode and coupling with fast electron is confirmed in hard X-ray emission with low-k // mode. The results are consistent with theoretical prediction based on 1.D full wave code. Synergetic effects between FWEH and LHCD are found. Coupling calculation indicates that eight-loop antenna is favourable for keeping high directivity in the required N // -range. Current drive efficiency is calculated with 1-D full wave code including trapped particle effects and higher harmonic ion cyclotron damping

Electromagnetic Cyclotron Waves in the Solar Wind: Wind Observation and Wave Dispersion Analysis

Science.gov (United States)

Jian, L. K.; Moya, P. S.; Vinas, A. F.; Stevens, M.

2016-01-01

Wind observed long-lasting electromagnetic cyclotron waves near the proton cyclotron frequency on 11 March 2005, in the descending part of a fast wind stream. Bi-Maxwellian velocity distributions are fitted for core protons, beam protons, and alpha-particles. Using the fitted plasma parameters we conduct kinetic linear dispersion analysis and find ion cyclotron and/or firehose instabilities grow in six of 10 wave intervals. After Doppler shift, some of the waves have frequency and polarization consistent with observation, thus may be correspondence to the cyclotron waves observed.

Two dimensional code for modeling of high ione cyclotron harmonic fast wave heating and current drive

International Nuclear Information System (INIS)

Grekov, D.; Kasilov, S.; Kernbichler, W.

2016-01-01

A two dimensional numerical code for computation of the electromagnetic field of a fast magnetosonic wave in a tokamak at high harmonics of the ion cyclotron frequency has been developed. The code computes the finite difference solution of Maxwell equations for separate toroidal harmonics making use of the toroidal symmetry of tokamak plasmas. The proper boundary conditions are prescribed at the realistic tokamak vessel. The currents in the RF antenna are specified externally and then used in Ampere law. The main poloidal tokamak magnetic field and the ''kinetic'' part of the dielectric permeability tensor are treated iteratively. The code has been verified against known analytical solutions and first calculations of current drive in the spherical torus are presented.

Electron Cyclotron Maser Emissions from Evolving Fast Electron Beams

Science.gov (United States)

Tang, J. F.; Wu, D. J.; Chen, L.; Zhao, G. Q.; Tan, C. M.

2016-05-01

Fast electron beams (FEBs) are common products of solar active phenomena. Solar radio bursts are an important diagnostic tool for understanding FEBs and the solar plasma environment in which they propagate along solar magnetic fields. In particular, the evolution of the energy spectrum and velocity distribution of FEBs due to the interaction with the ambient plasma and field during propagation can significantly influence the efficiency and properties of their emissions. In this paper, we discuss the possible evolution of the energy spectrum and velocity distribution of FEBs due to energy loss processes and the pitch-angle effect caused by magnetic field inhomogeneity, and we analyze the effects of the evolution on electron-cyclotron maser (ECM) emission, which is one of the most important mechanisms for producing solar radio bursts by FEBs. Our results show that the growth rates all decrease with the energy loss factor Q, but increase with the magnetic mirror ratio σ as well as with the steepness index δ. Moreover, the evolution of FEBs can also significantly influence the fastest growing mode and the fastest growing phase angle. This leads to the change of the polarization sense of the ECM emission. In particular, our results also reveal that an FEB that undergoes different evolution processes will generate different types of ECM emission. We believe the present results to be very helpful for a more comprehensive understanding of the dynamic spectra of solar radio bursts.

ELECTRON CYCLOTRON MASER EMISSIONS FROM EVOLVING FAST ELECTRON BEAMS

International Nuclear Information System (INIS)

Tang, J. F.; Wu, D. J.; Chen, L.; Zhao, G. Q.; Tan, C. M.

2016-01-01

Fast electron beams (FEBs) are common products of solar active phenomena. Solar radio bursts are an important diagnostic tool for understanding FEBs and the solar plasma environment in which they propagate along solar magnetic fields. In particular, the evolution of the energy spectrum and velocity distribution of FEBs due to the interaction with the ambient plasma and field during propagation can significantly influence the efficiency and properties of their emissions. In this paper, we discuss the possible evolution of the energy spectrum and velocity distribution of FEBs due to energy loss processes and the pitch-angle effect caused by magnetic field inhomogeneity, and we analyze the effects of the evolution on electron-cyclotron maser (ECM) emission, which is one of the most important mechanisms for producing solar radio bursts by FEBs. Our results show that the growth rates all decrease with the energy loss factor Q , but increase with the magnetic mirror ratio σ as well as with the steepness index δ . Moreover, the evolution of FEBs can also significantly influence the fastest growing mode and the fastest growing phase angle. This leads to the change of the polarization sense of the ECM emission. In particular, our results also reveal that an FEB that undergoes different evolution processes will generate different types of ECM emission. We believe the present results to be very helpful for a more comprehensive understanding of the dynamic spectra of solar radio bursts.

Fast neutron radiography testing for components of launch vehicles by a baby-cyclotron

International Nuclear Information System (INIS)

Ikeda, Y.; Ohkubo, K.; Matsumoto, G.; Nakamura, T.; Nozaki, Y.; Wakasa, S.; Toda, Y.; Kato, T.

1990-01-01

Recently, neutron radiography (NR) has become an important means of nondestructive testing (NDT) in Japan. Especially thermal neutron radiography testing (NRT) has been used for the NDT of various explosive devices of launch vehicles, which are developed as a H-series program by the National Space Development Agency (NASDA) of Japan. The NRT for launch vehicles has been carried out at the NR facility of a baby-cyclotron. In the NRT a conventional film method based on silver-halide emulsion has been exclusively employed to inspect various testing objects including components, and many valuable results have been obtained so far successfully. However, recently, the launch vehicles to be shot up have become much larger. With larger launch vehicles, the parts used in them have also become larger and thicker. One main disadvantage of the NRT by thermal neutrons is somewhat weak penetrability through objects because the energy is small. With the conventional thermal neutron radiography (TNR), steel objects being thicker than 40 to 50 mm are difficult to test through them because scattered neutrons obstruct real image of the object. Consequently a new method of NRT should be developed instead of TNR and applied to the new components of H-2 launch vehicles. In order to cope with the requirement, fast neutron radiography (FNR) has been studied for testing the new components of H-2, such as large separation bolts

Future cyclotron systems : an industrial perspective

International Nuclear Information System (INIS)

Stevenson, N.R.; Dickie, W.J.

1995-09-01

The use of commercial cyclotron systems for the production of radioisotopes continues to grow on a world-wide scale. Improvements in technology have significantly increased the production capabilities of modem cyclotron-based isotope production facilities. In particular, the change to negative ion acceleration and new high power systems have resulted in dramatic improvements in reliability, increases in capacity, and decreases in personnel radiation dose. As more and more older machines are retired decisions regarding their replacement are made based on several factors including the market's potential and the cyclotron system's abilities. Taking the case of the recently upgraded TR30 cyclotron at TRIUMF/Nordion, we investigate the requirements industrial/medical users are likely to impose on future commercial cyclotron systems and the impact this will have on cyclotron technology by the end of the century. (author)

Future cyclotron systems: An industrial perspective

International Nuclear Information System (INIS)

Stevenson, N.R.; Dickie, W.J.

1995-09-01

The use of commercial cyclotron systems for the production of radioisotopes continues to grow on a world-wide scale. Improvements in technology have significantly increased the production capabilities of modern cyclotron-based isotope production facilities. In particular, the change to negative ion acceleration and new high power systems have resulted in dramatic improvements in reliability, increases in capacity, and decreases in personnel radiation dose. As more and more older machines are retired, decisions regarding their replacement are made based on several factors including the market's potential and the cyclotron system's abilities. Taking the case of the recently upgraded TR30 cyclotron at TRIUMF/Nordion, the authors investigate the requirements industrial/medical users are likely to impose on future commercial cyclotron systems and the impact this will have on cyclotron technology by the end of the century

Electron cyclotron measurements with the fast scanning heterdyne radiometer on the tokamak fusion test reactor

International Nuclear Information System (INIS)

Taylor, G.; Efthimion, P.C.; McCarthy, M.P.; Fredd, E.A.; Cutler, R.C.

1986-01-01

Three fast scanning heterodyne receivers, swept between 75-110 GHz, 110-170 GHz, and 170-210 GHz, have measured electron cyclotron emission on the horizontal midplane of the tokamak fusion test reactor (TFTR) plasma. A second harmonic microwave mixer in the 170-210 GHz receiver allows the use of a 75-110 GHz backward wave oscillator as a swept local oscillator. Electron temperature profile evolution data with a time resolution of 2 msec and a profile acquisition rate of 250 Hz are presented for gas-fuelled and pellet-fuelled ohmic and neutral beam heated plasmas with toroidal fields up to 5.2 tesla. Recent results from a swept mode absolute calibration technique which can improve the accuracy and data collection efficiency during in-situ calibration are also presented

Hippocampal NPY gene transfer attenuates seizures without affecting epilepsy-induced impairment of LTP

DEFF Research Database (Denmark)

Sørensen, Andreas T; Nikitidou, Litsa; Ledri, Marco

2009-01-01

(TLE). However, our previous studies show that recombinant adeno-associated viral (rAAV)-NPY treatment in naive rats attenuates long-term potentiation (LTP) and transiently impairs hippocampal learning process, indicating that negative effect on memory function could be a potential side effect of NPY...... is significantly attenuated in vitro. Importantly, transgene NPY overexpression has no effect on short-term synaptic plasticity, and does not further compromise LTP in kindled animals. These data suggest that epileptic seizure-induced impairment of memory function in the hippocampus may not be further affected...... injected with rAAV-NPY, we show that rapid kindling-induced hippocampal seizures in vivo are effectively suppressed as compared to rAAV-empty injected (control) rats. Six to nine weeks later, basal synaptic transmission and short-term synaptic plasticity are unchanged after rapid kindling, while LTP...

NPY intraperitoneal injections produce antidepressant-like effects and downregulate BDNF in the rat hypothalamus.

Science.gov (United States)

Gelfo, Francesca; Tirassa, Paola; De Bartolo, Paola; Croce, Nicoletta; Bernardini, Sergio; Caltagirone, Carlo; Petrosini, Laura; Angelucci, Francesco

2012-06-01

Several studies have documented an involvement of Neuropeptide Y (NPY) in stress-related disorders. Stress-related disorders are also characterized by changes in brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), neurotrophins implicated in the survival and function of neurons. Thus the aim of this study was to investigate whether an NPY intraperitoneal treatment has antidepressant-like effects in rats subjected to a classical stress paradigm, the Forced Swim Test (FST), in association with changes in local brain neurotrophin production. Rats were intraperitoneally injected with either NPY (60 μg/kg) or a vehicle for three consecutive days between two FST sessions and then tested for time spent (or delay onset) in immobile posture. Moreover, we measured by enzyme-linked immunosorbent assay (ELISA) neurotrophin levels in the hypothalamus and corticosterone levels in plasma. The data showed that NPY induced a significant delay in the onset and a significant reduction in the duration of the immobility posture in FST. We also found that NPY decreased BDNF levels in the hypothalamus and corticosterone levels in plasma. Immobility posture in FST can be reduced by antidepressant drugs. Thus, our data show an antidepressant-like effect of NPY associated with changes in BDNF levels in the hypothalamus and reduced activity of hypothalamic-pituitary-adrenal (HPA) axis. These findings, while confirming the involvement of the NPY system in stress-related disorders, suggest that a less invasive route of administration, such as an intraperitoneal injection, may be instrumental in coping with stressful events in animal models and perhaps in humans. © 2012 Blackwell Publishing Ltd.

On the automatic control of the ITER ion cyclotron system

Energy Technology Data Exchange (ETDEWEB)

Bosia, G. [Department of General Physics, University of Turin, Via P. Giuria 1, 10 125 Turin (Italy)], E-mail: giuseppe.bosia@to.infn.it

2007-10-15

The ITER ion cyclotron heating system requires an efficient control system capable of: (i) providing the desired array radiation spectrum, to optimize plasma coupling and absorption and to minimize parasitic power losses in the plasma edge; (ii) maintaining the RF power flow to the plasma against significant load variations, including fast fluctuations induced by ELMs; (iii) reliably detecting and suppressing RF voltage breakdowns in the array and/or in the transmission system, to avoid local equipment damage and (iv) implementing an accurate real time record of performance. In this paper specific aspects of the tuning control system, related to recent conceptual and engineering effort [K. Vulliez, et al., Design of the ITER ion cyclotron heating launcher based on in-vessel tuning system, Article ID106C, this conference] are addressed.

Ion cyclotron emission by spontaneous emission

Energy Technology Data Exchange (ETDEWEB)

Da Costa, O [Commission of the European Communities, Abingdon (United Kingdom). JET Joint Undertaking; Gresillon, D [Ecole Polytechnique, 91 - Palaiseau (France). Lab. de Physique des Milieux Ionises

1994-07-01

The goal of the study is to examine whether the spontaneous emission can account for ICE (ion cyclotron emission) experimental results, or part of them. A straightforward approach to plasma emission is chosen, investigating the near equilibrium wave radiation by gyrating ions, and thus building from the majority and fast fusion ions the plasma fluctuations and emission on the fast magnetoacoustic or compressional Alfven wave mode in the IC frequency range. Similarities with the ICE experiments are shown: the emission temperature in the presence of fast ions (even in a very small amount), the strong fast ion emission increase with the harmonic, the fine double-line splitting of each peak, the linear but not proportional increase of the peak width with the harmonic. 3 refs., 2 figs.

Ion cyclotron emission by spontaneous emission

International Nuclear Information System (INIS)

Da Costa, O.; Gresillon, D.

1994-01-01

The goal of the study is to examine whether the spontaneous emission can account for ICE (ion cyclotron emission) experimental results, or part of them. A straightforward approach to plasma emission is chosen, investigating the near equilibrium wave radiation by gyrating ions, and thus building from the majority and fast fusion ions the plasma fluctuations and emission on the fast magnetoacoustic or compressional Alfven wave mode in the IC frequency range. Similarities with the ICE experiments are shown: the emission temperature in the presence of fast ions (even in a very small amount), the strong fast ion emission increase with the harmonic, the fine double-line splitting of each peak, the linear but not proportional increase of the peak width with the harmonic. 3 refs., 2 figs

Quantitative Study of NPY-Expressing GABAergic Neurons and Axons in Rat Spinal Dorsal Horn*

OpenAIRE

Polg?r, Erika; Sardella, Thomas CP; Watanabe, Masahiko; Todd, Andrew J

2010-01-01

Between 25?40% of neurons in laminae I?III are GABAergic, and some of these express neuropeptide Y (NPY). We previously reported that NPY-immunoreactive axons form numerous synapses on lamina III projection neurons that possess the neurokinin 1 receptor (NK1r). The aims of this study were to determine the proportion of neurons and GABAergic boutons in this region that contain NPY, and to look for evidence that they selectively innervate different neuronal populations. We found that 4?6% of ne...

The Juelich compact cyclotron - a multi-purpose irradiation facility

International Nuclear Information System (INIS)

Hemmerich, J.; Hoelzle, R.; Kogler, W.

1977-01-01

A commercially available variable-energy compact cyclotron has been installed at the Kernforschungsanlage Juelich. It is equipped to accelerate protons, deuterons, 3 He- and α-particles. A +- 60 0 switching magnet allows to switch the beam to any of seven external target stations. Three separately shielded target rooms allow a flexible use of the cyclotron for a wide range of applications such as production of short-lived nuclides, activation analysis, radiation damage studies in metals and studies of biological effects of fast neutron irradiation. (orig.) [de

Bone Injury and Repair Trigger Central and Peripheral NPY Neuronal Pathways.

Directory of Open Access Journals (Sweden)

Cecília J Alves

Full Text Available Bone repair is a specialized type of wound repair controlled by complex multi-factorial events. The nervous system is recognized as one of the key regulators of bone mass, thereby suggesting a role for neuronal pathways in bone homeostasis. However, in the context of bone injury and repair, little is known on the interplay between the nervous system and bone. Here, we addressed the neuropeptide Y (NPY neuronal arm during the initial stages of bone repair encompassing the inflammatory response and ossification phases in femoral-defect mouse model. Spatial and temporal analysis of transcriptional and protein levels of NPY and its receptors, Y1R and Y2R, reported to be involved in bone homeostasis, was performed in bone, dorsal root ganglia (DRG and hypothalamus after femoral injury. The results showed that NPY system activity is increased in a time- and space-dependent manner during bone repair. Y1R expression was trigged in both bone and DRG throughout the inflammatory phase, while a Y2R response was restricted to the hypothalamus and at a later stage, during the ossification step. Our results provide new insights into the involvement of NPY neuronal pathways in bone repair.

Fast wave absorption at the Alfven resonance during ion cyclotron resonance heating

International Nuclear Information System (INIS)

Heikkinen, J.A.; Hellsten, T.; Alava, M.J.

1991-01-01

For ICRH scenarii where the majority cyclotron resonance intersects the plasma core, mode conversion of the fast magnetosonic wave to an Alfven wave takes place at the plasma boundary on the high field side. Simple analytical estimates of the converted power for this mode conversion process are derived and compared with numerical calculations including finite electron inertia and kinetic effects. The converted power is found to depend on the local value of the wave field as well as on plasma parameters at the Alfven wave resonance. The interference with the reflected wave will therefore modify the mode conversion. If the conversion layer is localized near the wall, the conversion will be strongly reduced. The conversion coefficient is found to be strongest for small density gradients and high density and it is sensitive to the value of the parallel wave number. Whether it increases or decreases with the latter depends on the ion composition. Analysis of this problem for ICRH in JET predicts that a large fraction of the power is mode converted at the plasma boundary for first harmonic heating of tritium in a deuterium-tritium plasma. (author). 13 refs, 10 figs, 1 tab

Building on TR-24 success. Advanced Cyclotron Systems Inc. launches a new cyclotron model

International Nuclear Information System (INIS)

Russell Watt; William Gyles; Alexander Zyuzin

2015-01-01

ACSI is designing a new 30 MeV cyclotron based on the TR-24. While minimizing changes from the proven TR-24, including maintaining the same outer dimensions, the energy of the cyclotron will be increased to 30 MeV, which will make it the most compact, non-superconducting, 30 MeV cyclotron design to date. Maximum beam current will match the TR-24 at 1 mA. With the size and footprint of a typical low energy PET cyclotron, this system will offer users a cost effective solution for a diversified facility capable of producing a wide spectrum of PET and SPECT radioisotopes for research and commercial distribution. (author)

NPY-leptin : opposing effects on appetitive and consummatory ingestive behavior and sexual behavior

NARCIS (Netherlands)

Ammar, AA; Sederholm, F; Saito, TR; Scheurink, AJW; Johnson, AE; Södersten, P.

Many studies have indicated that neuropeptide Y (NPY) stimulates and leptin inhibits food intake. In line with this, intracerebroventricular injection of NPY (10 mu g) stimulated and leptin (10 mu g) inhibited intake of a sucrose solution when female rats were required to obtain the solution from a

Neutron thermalization in reactor lattice cells: An NPY-project report

International Nuclear Information System (INIS)

Stamm'ler, R.J.J.; Takac, S.M.; Weiss, Z.J.

1966-01-01

The NPY-Project is a joint research programme in reactor physics between Norway, Poland, Yugoslavia and the International Atomic Energy Agency. One of the tasks of the project was to make a theoretical and experimental investigation of the phenomena of neutron thermalization in lattice cells, and this work is covered by the present monograph. The different lattices of the zero-power assemblies in the NPY countries offered ample opportunity for the theoreticians and experimentalists to test and compare their methods, and the exchange of experiences was stimulating and valuable. 85 refs, 26 figs, 19 tabs

Clinical significance of determination of plasma ET and serum NSE, NPY levels in patients with Alzheimer diseases (AD)

International Nuclear Information System (INIS)

Song Hua

2009-01-01

Objective: To explore the clinical significance of changes of plasma ET and serum NSE, NPY levels in patients with Alzheimer diseases. Methods: Plasma ET and serum NSE, NPY levels were determined with RIA in 31 patients with Alzheimer diseases and 30 controls. Results: The plasma ET and serum NSE, NPY levels in the patients were significantly higher than those in controls (P<0.01). Plasma ET and serum NSE, NPY levels were mutually positively correlated (r=0.4895, 0.6014, P<0.01). Conclusion: Detection of plasma ET and serum NSE, NPY levels was helpful for the prediction of treatment effieacy in patients with Alzheimer diseases. (authors)

Effect of hot α-particles on ion cyclotron absorption

International Nuclear Information System (INIS)

Cairns, R.A.; Kay, A.; Lashmore-Davies, C.N.

1987-01-01

Ion cyclotron heating involves mode conversion of the incident fast wave to a Bernstein mode, which is generally stongly damped and only propagates in a localized region of the plasma. The usual theoretical approach to this problem involves solution of fourth or higher order equations, but by treating the Bernstein mode as a driven response to the fast wave we obtain a simple second order equation. Comparison of its solutions with those of higher order equations shows that this approach gives good results. The same method can be used to consider the effect of a small population of hot α-particles on ion cyclotron heating, since it does away with the need for a small larmor radius expansion. The results indicate that a small concentration of α-particles can absorb a substantial fraction of the incident energy

The Role of Neuropeptide Y (NPY) in Uncontrolled Alcohol Drinking and Relapse Behavior Resulting from Exposure to Stressful Events

National Research Council Canada - National Science Library

Thiele, Todd E; Knapp, Darin J; Breese, George; McCown, Thomas J

2007-01-01

.... An interesting candidate is neuropeptide Y (NPY). Recent evidence suggests that low NPY levels promote high alcohol consumption, and it has been established the NPY protects against stress and anxiety...

Medical Cyclotrons

Science.gov (United States)

Friesel, D. L.; Antaya, T. A.

Particle accelerators were initially developed to address specific scientific research goals, yet they were used for practical applications, particularly medical applications, within a few years of their invention. The cyclotron's potential for producing beams for cancer therapy and medical radioisotope production was realized with the early Lawrence cyclotrons and has continued with their more technically advanced successors — synchrocyclotrons, sector-focused cyclotrons and superconducting cyclotrons. While a variety of other accelerator technologies were developed to achieve today's high energy particles, this article will chronicle the development of one type of accelerator — the cyclotron, and its medical applications. These medical and industrial applications eventually led to the commercial manufacture of both small and large cyclotrons and facilities specifically designed for applications other than scientific research.

Cyclotron operating mode determination based on intelligent methods

International Nuclear Information System (INIS)

Ouda, M.M.E.M.

2011-01-01

Particle accelerators are generators that produce beams of charged particles with energies depending on the accelerator type. The MGC-20 cyclotron is a cyclic particle accelerator used for accelerating protons, deuterons, alpha particles, and helium-3 to different energies. Main applications are isotopes production, nuclear reactions studies, and mass spectroscopy studies and other industrial applications. The cyclotron is a complicated machine depends on using a strong magnetic field and high frequency-high voltage electric field together to accelerate and bend charged particles inside the accelerating chamber. It consists of the following main parts, the radio frequency system, the main magnet with the auxiliary concentric and harmonic coils, the electrostatic deflector, and the ion source, the beam transport system, and high precision and high stability DC power supplies.To accelerate a particle to certain energy, one has to adjust the cyclotron operating parameters to be suitable to accelerate this particle to that energy. If the cyclotron operating parameters together are adjusted to accelerate a charged particle to certain energy, then these parameters together are named the operating mode to accelerate this particle to that energy. For example the operating mode to accelerate protons to 18 MeV is named the (18 MeV protons operating mode). The operating mode includes many parameters that must be adjusted together to be successful to accelerate, extract, focus, steer a particle from the ion source to the experiment. Due to the big number of parameters in the operating modes, 19 parameters have been selected in this thesis to be used in an intelligent system based on feed forward back propagation neural network to determine the parameters for new operating modes. The new intelligent system depends on the available information about the currently used operating modes.The classic way to determine a new operating mode was depending on trial and error method to

Automated cyclotron tuning using beam phase measurements

International Nuclear Information System (INIS)

Timmer, J.H.; Roecken, H.; Stephani, T.; Baumgarten, C.; Geisler, A.

2006-01-01

The ACCEL K250 superconducting cyclotron is specifically designed for the use in proton therapy systems. The compact medical 250 MeV proton accelerator fulfils all present and future beam requirements for fast scanning treatment systems and is delivered as a turn key system; no operator is routinely required. During operation of the cyclotron heat dissipation of the RF system induces a small drift in iron temperature. This temperature drift slightly detunes the magnetic field and small corrections must be made. A non-destructive beam phase detector has been developed to measure and quantify the effect of a magnetic field drift. Signal calculations were made and the design of the capacitive pickup probe was optimised to cover the desired beam current range. Measurements showed a very good agreement with the calculated signals and beam phase can be measured with currents down to 3 nA. The measured phase values are used as input for a feedback loop controlling the current in the superconducting coil. The magnetic field of the cyclotron is tuned automatically and online to maintain a fixed beam phase. Extraction efficiency is thereby optimised continuously and activation of the cyclotron is minimised. The energy and position stability of the extracted beam are well within specification

A novel fast-scanning microwave heterodyne radiometer system for electron cyclotron emission measurements in the HT-7 superconducting tokamak

International Nuclear Information System (INIS)

Zhang, S.Y.; Wan, Y.X.; Xie, J.K.; Luo, J.R.; Li, J.G.; Kuang, G.L.; Gao, X.; Zhang, X.D.; Wan, B.N.; Wang, K.J.; Mao, J.S.; Gong, X.Z.; Qin, P.J.

2000-01-01

Two sets of fast-scanning microwave heterodyne radiometer receiver systems employing backward-wave oscillators in the 78-118 GHz and 118-178 GHz ranges were developed for electron cyclotron emission measurements (ECE) on the HT-7 superconducting tokamak. The double-sideband radiometer in the 78-118 GHz range measures 16 ECE frequency points with a scanning period of 0.65 ms. The novel design of the 2 mm fast-scanning heterodyne radiometer in the 118-178 GHz range enables the unique system to measure 48 ECE frequency points in 0.65 ms periodically. The plasma profile consistency in reproducible ohmic plasmas was used to relatively calibrate each channel by changing the toroidal magnetic field shot-by-shot. The absolute temperature value was obtained by a comparison with the results from the soft x-ray pulse height analysis measurements and Thomson scattering system. A preliminary temperature profile measurement result in pellet injection plasma is presented. (author)

Enhanced Y1-receptor-mediated vasoconstrictive action of neuropeptide Y (NPY) in superior mesenteric arteries in portal hypertension.

Science.gov (United States)

Wiest, Reiner; Jurzik, Lars; Moleda, Lukas; Froh, Matthias; Schnabl, Bernd; von Hörsten, Stephan; Schölmerich, Juergen; Straub, Rainer H

2006-03-01

Vascular hyporeactivity to catecholamines contributes to arterial vasodilation and hemodynamic dysregulation in portal hypertension. Neuropeptide Y (NPY) is a sympathetic neurotransmitter facilitating adrenergic vasoconstriction via Y1-receptors on the vascular smooth muscle. Therefore, we investigated its role for vascular reactivity in the superior mesenteric artery (SMA) of portal vein ligated (PVL) and sham operated rats. In vitro perfused SMA vascular beds of rats were tested for the cumulative dose-response to NPY dependent on the presence and level of alpha1-adrenergic vascular tone (methoxamine MT: 0.3-10 microM). Moreover, the effect of NPY (50 nM) on vascular responsiveness to alpha1-adrenergic stimulation (MT: 0.3-300 microM) was evaluated. Y1-receptor function was tested by Y1-selective inhibition using BIBP-3226 (1 microM). NPY dose-dependently and endothelium-independently enhanced MT-pre-constriction in SMA. This potentiation was increasingly effective with increasing adrenergic pre-stimulation and being more pronounced in PVL rats as compared to sham rats at high MT concentrations. NPY enhanced vascular contractility only in PVL rats correcting the adrenergic vascular hyporeactivity. Y1-receptor inhibition completely abolished NPY-evoked vasoconstrictive effects. NPY endothelium-independently potentiates adrenergic vasoconstriction via Y1-receptors being more pronounced in portal hypertension improving mesenteric vascular contractility and thereby correcting the splanchnic vascular hyporeactivity. This makes NPY a superior vasoconstrictor counterbalancing arterial vasodilation in portal hypertension.

Experiments on ion cyclotron damping at the deuterium fourth harmonic in DIII-D

International Nuclear Information System (INIS)

Pinsker, R.I.; Petty, C.C.; Baity, F.W.; Bernabei, S.; Greenough, N.; Heidbrink, W.W.; Mau, T.K.; Porkolab, M.

1999-05-01

Absorption of fast Alfven waves by the energetic ions of an injected beam is evaluated in the DIII-D tokamak. Ion cyclotron resonance absorption at the fourth harmonic of the deuteron cyclotron frequency is observed with deuterium neutral beam injection (f = 60 MHz, B T = 1.9 T). Enhanced D-D neutron rates are evidence of absorption at the Doppler-shifted cyclotron resonance. Characteristics of global energy confinement provide further proof of substantial beam acceleration by the rf. In many cases, the accelerated deuterons cause temporary stabilization of the sawtooth (monster sawteeth), at relatively low rf power levels of ∼1 MW

A critical evaluation of the role of the cyclotron in radiation therapy

International Nuclear Information System (INIS)

Wolber, G.

1984-01-01

The present situation in heavy particle radiotherapy is reviewed. The potential of the cyclotron and competing devices is evaluated with respect to dose distribution, dose rate, versatility, size, and cost. Some related non-physical problems characterizing radiation therapy in general are briefly considered. It turns out that compact cyclotrons for 30 to 60 MeV protons hold their leading position in fast neutron therapy at least, as they do in radioisotope production

Comparison of a high-carbohydrate and high-protein breakfast effect on plasma ghrelin, obestatin, NPY and PYY levels in women with anorexia and bulimia nervosa

Directory of Open Access Journals (Sweden)

Sedlackova Dana

2012-06-01

Full Text Available Abstract Background The present study investigated plasma levels of gut-brain axis peptides ghrelin, obestatin, NPY and PYY after consumption of a high-carbohydrate (HC and high-protein (HP breakfast in patients with anorexia nervosa, bulimia nervosa and in healthy controls. These peptides play an important role in regulation of energy homeostasis and their secretion is disturbed under condition of eating disorders. As various types of consumed macronutrients may induce different plasma hormone responses, so we examined these responses in women patients with eating disorders and compared them with those of healthy controls. Methods We examined plasma hormone responses to HC and HP breakfast in patients with AN (n = 14; age: 24.6 ± 1.8 years, BMI: 15.3 ± 0.7, BN (n = 15; age: 23.2 ± 1.7 years, BMI: 20.5 ± 0.9 and healthy controls (n = 14; age: 24.9 ± 1.4 years, BMI: 21.1 ± 0.8. Blood samples were drawn from the cubital vein, the first blood drawn was collected before meal, and then 30, 60, 90, 120 and 150 min after breakfast consumption. Plasma hormone levels were determined by commercially available RIA kits. Results Fasting and postprandial plasma obestatin levels were significantly increased in both AN and BN patients, while plasma ghrelin levels were significantly increased in AN patients only. After breakfast consumption, plasma levels of ghrelin and obestatin decreased, although they were still above the range of values of healthy controls. Fasting NPY plasma levels were significantly increased in AN and BN patients and did not change postprandially. Fasting PYY levels were comparable in AN, BN and healthy controls, but postprandially significantly increased after HP breakfast in AN and BN patients. Different reactions to breakfast consumption was found for ghrelin and PYY among investigated groups, while for obestatin and NPY these reactions were similar in all groups. Conclusions Significant

Knowledge and experiences of needle prick injuries (NPI) among ...

African Journals Online (AJOL)

of acquiring blood-borne infections from the workplace. ... Adequate knowledge and adherence to safety practices could prevent the occurrence of NPI and the related ..... managers, develop surveillance systems, immunise against hepatitis.

Control philosophy and diagnostic systems of Superconducting Cyclotron

International Nuclear Information System (INIS)

Roy, Anindya; Bhattacharjee, Tanushyam; Chaddha, N.; Bhole, R.B.; Pal, Sarbajit; Samanta, N.C.; Dutta, C.D.; Mukhopadhyay, B.; Panda, U.S.; Sarkar, B.; Nabhiraj, P.Y.; Sarkar, D.

2009-01-01

The control system has the primary task of monitoring and control of all the important parameters of a machine comprises of various sub-systems. The paper describes the philosophy of the distributed control system of Superconducting Cyclotron implemented with the support of reliable and fast control network. The paper also describes the field hardware interfaced with various software platforms at different levels of individual sub-systems e.g. Main Magnet Power Supply, Trim-coil Power Supplies, He Liquefier/Refrigerator Plant, Cryogen Delivery System, RF System, ECR Ion source, Vacuum System, Radiation Monitoring System, Alarm Annunciation System, LCW System of SC Cyclotron. The database management system facilitating the exchange of control data among the sub-systems, serving as primary source of information to understand the behavior of the cyclotron, is also discussed. A brief description of various beam diagnostic instruments and their respective control systems e.g. Main Probe, Borescope, Beam viewer, Magnetic channel control system, Beam line slit control system, are briefly described. (author)

Correlations of serum levels of leptin and other related factor (NPY, ADP) in female children with simple obesity

International Nuclear Information System (INIS)

Bai Hua; Wei Chunlei; Qian Mingzhu

2008-01-01

Objective: To study the changes of serum levels of leptin, NPY and ADP in female children with simple obesity. Methods: Serum levels of leptin, NPY and ADP were measured with radioimmunoassay (RIA) in 32 female children with simple obesity and 35 controls. Results: The serum levels of leptin, NPY were significantly higher in the obese children than those in controls (P<0.01), while the serum levels of ADP were significantly lower (P<0.01). Serum leptin levels were significantly positively correlated (r=0.6014, P<0.01) with NPY levels but were negatively correlated (r=-0.4786, P<0.01) with adiponectin (ADP) levels. Conclusion: Determination of serum leptin, NPY and ADP levels is of help for judgement of degree of obesity as wen as outcome prediction in female children. (authors)

Radiation safety and operational health physics of hospital based medical cyclotrons

International Nuclear Information System (INIS)

Mukherjee, B.

2002-01-01

Full text: Compact, low energy, high current Medical Cyclotrons are now primarily used to produce large activities of short lived, neutron deficient, positron- emitting radioisotopes. These isotopes constitute the key ingredients of important PET (Positron Emission Tomography) radiopharmaceuticals used in diagnostic nuclear medicine. The PET-radioisotope producing Medical Cyclotrons are now increasingly installed in modern urban hospitals in many countries of the world. Modern Medical Cyclotrons run at a very high beam current (∼100-200 micro Amp) level and thereby produce intense fields of parasitic gamma rays and neutrons, causing the activation of cyclotron components, ambient air and radiation exposure to patients and members of the public. This report highlights the important operational aspects and the characteristics of the radiation fields produced by Medical Cyclotrons. The pathways of personnel radiation exposure are also analyzed. The above information constitutes the scientific basis of a sound operational health physics service, which is manifested in an effective dose reduction and an enhanced radiological safety of the Medical Cyclotron facility within the framework of ALARA

Development of neuropeptide Y (NPY) immunoreactive neurons in the rat occipital cortex: A combined immunohistochemical-autoradiographic study

International Nuclear Information System (INIS)

Cavanagh, M.E.; Parnavelas, J.G.

1990-01-01

The postnatal development of neuropeptide Y (NPY)-immunoreactive neurons, previously labeled with [3H]thymidine on embryonic days E14-E21, has been studied in the rat occipital cortex. Immunohistochemistry combined with autoradiography showed evidence of a modified inside-out pattern of maturation. NPY-neurons are generated between E14 and E20 and are found in layers II-VI of the cortex and the subcortical white matter. NPY neurons from all these birthdates are overproduced at first, although cells generated at E16 produce the greatest excess, followed by E15 and E17. Some of these transient neurons are found in the wrong layer for their birthdates, and their elimination produces a more correct alignment at maturity. However, most of the NPY neurons that survive are generated at E17, and these cells are found throughout layers II-VI with a preponderance in layer VI. This evidence is strongly suggestive of cell death rather than merely cessation of production of NPY

Cyclotron resonance cooling by strong laser field

International Nuclear Information System (INIS)

Tagcuhi, Toshihiro; Mima, Kunioka

1995-01-01

Reduction of energy spread of electron beam is very important to increase a total output radiation power in free electron lasers. Although several cooling systems of particle beams such as a stochastic cooling are successfully operated in the accelerator physics, these cooling mechanisms are very slow and they are only applicable to high energy charged particle beams of ring accelerators. We propose here a new concept of laser cooling system by means of cyclotron resonance. Electrons being in cyclotron motion under a strong magnetic field can resonate with circular polarized electromagnetic field, and the resonance take place selectively depending on the velocity of the electrons. If cyclotron frequency of electrons is equal to the frequency of the electromagnetic field, they absorb the electromagnetic field energy strongly, but the other electrons remain unchanged. The absorbed energy will be converted to transverse kinetic energy, and the energy will be dumped into the radiation energy through bremastrahlung. To build a cooling system, we must use two laser beams, where one of them is counter-propagating and the other is co-propagating with electron beam. When the frequency of the counter-propagating laser is tuned with the cyclotron frequency of fast electrons and the co-propagating laser is tuned with the cyclotron frequency of slow electrons, the energy of two groups will approach and the cooling will be achieved. We solve relativistic motions of electrons with relativistic radiation dumping force, and estimate the cooling rate of this mechanism. We will report optimum parameters for the electron beam cooling system for free electron lasers

A small potassium current in AgRP/NPY neurons regulates feeding behavior and enery metabolism

Science.gov (United States)

Neurons that co-express agouti-related peptide (AgRP) and neuropeptide Y (NPY) are indispensable for normal feeding behavior. Firing activities of AgRP/NPY neurons are dynamically regulated by energy status and coordinate appropriate feeding behavior to meet nutritional demands. However, intrinsic m...

Health physics and quality control management of a cyclotron-based PET facility

International Nuclear Information System (INIS)

Jerabek, P.A.

1995-01-01

This paper provides an overview of the operation and management of a Positron Emission Tomography (PET) facility at the University of Texas. The facility components are discussed from an operations perspective with an emphasis on devices, and on practices and procedures which are implemented to ensure that personnel exposures are as low as reasonably achievable. The cyclotron-based PET facility uses in-house production of PET radioisotopes for preparation of radiopharmaceuticals. A combination of specially designed cyclotron equipped devices, radiopharmaceutical preparation devices, and shielded devices along with health physics practices have helped to make PET operations become routine

Experiments on ion cyclotron damping at the deuterium fourth harmonic in DIII-D

International Nuclear Information System (INIS)

Pinsker, R. I.; Baity, F. W.; Bernabei, S.; Greenough, N.; Heidbrink, W. W.; Mau, T. K.; Petty, C. C.; Porkolab, M.

1999-01-01

Absorption of fast Alfven waves by the energetic ions of an injected beam is evaluated in the DIII-D tokamak. Ion cyclotron resonance absorption at the fourth harmonic of the deuteron cyclotron frequency is observed with deuterium neutral beam injection (f=60 MHz, B T =1.9 T). Enhanced D-D neutron rates are evidence of absorption at the Doppler-shifted cyclotron resonance. Characteristics of global energy confinement provide further proof of substantial beam acceleration by the rf. In many cases, the accelerated deuterons cause temporary stabilization of the sawtooth (''monster sawteeth''), at relatively low rf power levels of ∼1 MW. (c) 1999 American Institute of Physics

The clinical application of determination of plasma NPY levels for diagnosis and treatment of cardiovascular diseases

International Nuclear Information System (INIS)

Zheng Qing; Bao Yimin; Yang Yongqing

2010-01-01

Objective: To study the clinical usefulness of determination of plasma NPY levels for diagnosis and treatment of cardiovascular disease. Methods: Plasma levels of NPY were determined with RIA in 180 patients with heart failure from CHD, 89 patients with AMI, 58 patients with essential hypertension, 109 patients with PIH and 47 controls. Results: The plasma levels of NPY in 180 patients with heart failure were 206.37±40.1 pg/ml (I grade, P<0.05), 218.62±64.83 pg/ml (II grade, P<0.05), 269.16±56.57 pg/ml (III grade, P<0.01) and 314.82±56.73 pg/ml (IV grade, P<0.001), respectively. The plasma levels were 345.12±68.71 pg/ml and 191.46±38.92 pg/ml in patients with AMI and hypertension as a whole, respectively. All these levels were significantly higher than those in controls (P<0.05∼0.001). Among the patients, the plasma NPY levels increased along with advance of the disease process. Conclusion: Plasma NPY level was a useful marker for diagnosis and treatment of cardiovascular diseases. (authors)

How cyclotrons work

International Nuclear Information System (INIS)

Nolan, D.

1992-01-01

The operating principles of a cyclic accelerator are presented based on the IBA Cyclone 30 negative ion cyclotron, selected for the Australia's first medical cyclotron. Its main features are: acceleration with variable energy of between 15-30 million electron volts, the capability of extracting two beams simultaneously, low power consumption, easy maintenance. Other aspects not directly related to the principle of operation discussed include the vacuum and the radio-frequency systems as well as the complex computerized control system used to automatically control start-up and shut-down operations. ills

Cyclotron based nuclear science: Progress report, April 1, 1987-March 31, 1988

International Nuclear Information System (INIS)

1988-08-01

This report discusses experiment run on the K500 cyclotron and 88 in cyclotron at Texas AandM University. The main topics of these experiments are: Heavy ion reactions; Nuclear structure and fundamental interactions; Atomic and material science; Nuclear theory; and Superconducting cyclotron and instrumentation

Export of radiopharmaceuticals and establishment of export base of cyclotron

International Nuclear Information System (INIS)

Jung, Kyungil; Kim, Youngsik

2006-01-01

Sam young Unit ech has seized an opportunity to advance into the radiopharmaceuticals market through successful transfer of radiopharmaceuticals manufacturing technology and medical cyclotron, an original technology in nuclear medicine that is the core of less developed areas in nuclear-related fields. The company has continued to push for research development and establishment of market base through industry-academia-research center cooperation with an aim to complement relatively less developed domestic technology and market than in advanced countries, and is making efforts to establish export base in the overseas market based on stabilized supply in the domestic market. As for radiopharmaceuticals, the company is exporting Tc-99m generator to Vietnam, Thailand and the Philippines and preparing itself to export manufacture facilities for Tc-99m generator to Syria and Kazakhstan. In addition, it plans to export 13Mev Cyclotron that has been commercialized after being developed in the domestic market to the U. S. The company plans to grow up to play a pivotal role in the domestic RT area by conducting proactive business activities with an aim to revitalize the domestic market and further domestic original technologies and products in the global market

Vancouver Cyclotron Conference

International Nuclear Information System (INIS)

Clark, David J.

1993-01-01

Although no longer on the high energy frontier, the cyclotron field is still a major scientific growth area. Its progress is highlighted at the international conference on cyclotron design, development and utilization held at intervals of about three years, under the auspices of the International Union of Pure and Applied Physics (IUPAP). Vancouver, surrounded by mountains, water and some cyclotrons, provided a pleasant setting for the 13th Conference, held last summer. With over 200 cyclotrons in operation around the world, the attendance, 241 delegates and 26 industrial exhibitors, was a near record, reflecting the flourishing state of the field. The early sessions covered the initial operation of new or upgraded cyclotron facilities. Major facilities completed since the previous Conference in Berlin in May 1989 included the 400 MeV ring cyclotron at Osaka, the U400M cyclotron at Dubna which will be coupled to the U400 to give 20 MeV nucléon uranium beams, the 130 MeV cyclotron at Jyvaskyla (in Finland, the furthest north!), the 110 MeV JAERI machine in Japan, and the 65 MeV proton therapy cyclotron in Nice. Among the facility upgrades were the KFA cyclotron at Julich which will inject the 2.5 GeV storage ring COSY, and the addition of an FM mode to the K=200 CW mode at Uppsala to give protons up to 180 MeV. The impressive current of 1.5 mA at 72 MeV obtained from the PSI Injector II will soon be injected into the 590 MeV ring

Development of a Medical Cyclotron Production Facility

Science.gov (United States)

Allen, Danny R.

2003-08-01

Development of a Cyclotron manufacturing facility begins with a business plan. Geographics, the size and activity of the medical community, the growth potential of the modality being served, and other business connections are all considered. This business used the customer base established by NuTech, Inc., an independent centralized nuclear pharmacy founded by Danny Allen. With two pharmacies in operation in Tyler and College Station and a customer base of 47 hospitals and clinics the existing delivery system and pharmacist staff is used for the cyclotron facility. We then added cyclotron products to contracts with these customers to guarantee a supply. We partnered with a company in the process of developing PET imaging centers. We then built an independent imaging center attached to the cyclotron facility to allow for the use of short-lived isotopes.

Development of a Medical Cyclotron Production Facility

International Nuclear Information System (INIS)

Allen, Danny R.

2003-01-01

Development of a Cyclotron manufacturing facility begins with a business plan. Geographics, the size and activity of the medical community, the growth potential of the modality being served, and other business connections are all considered. This business used the customer base established by NuTech, Inc., an independent centralized nuclear pharmacy founded by Danny Allen. With two pharmacies in operation in Tyler and College Station and a customer base of 47 hospitals and clinics the existing delivery system and pharmacist staff is used for the cyclotron facility. We then added cyclotron products to contracts with these customers to guarantee a supply. We partnered with a company in the process of developing PET imaging centers. We then built an independent imaging center attached to the cyclotron facility to allow for the use of short-lived isotopes

Ion cyclotron resonance heating

International Nuclear Information System (INIS)

Tajima, T.

1982-01-01

Ion cyclotron resonance heating of plasmas in tokamak and EBT configurations has been studied using 1-2/2 and 2-1/2 dimensional fully self-consistent electromagnetic particle codes. We have tested two major antenna configurations; we have also compared heating efficiencies for one and two ion species plasmas. We model a tokamak plasma with a uniform poloidal field and 1/R toroidal field on a particular q surface. Ion cyclotron waves are excited on the low field side by antennas parallel either to the poloidal direction or to the toroidal direction with different phase velocities. In 2D, minority ion heating (vsub(perpendicular)) and electron heating (vsub(parallel),vsub(perpendicular)) are observed. The exponential electron heating seems due to the decay instability. The minority heating is consistent with mode conversion of fast Alfven waves and heating by electrostatic ion cyclotron modes. Minority heating is stronger with a poloidal antenna. The strong electron heating is accompanied by toroidal current generation. In 1D, no thermal instability was observed and only strong minority heating resulted. For an EBT plasma we model it by a multiple mirror. We have tested heating efficiency with various minority concentrations, temperatures, mirror ratios, and phase velocities. In this geometry we have beach or inverse beach heating associated with the mode conversion layer perpendicular to the toroidal field. No appreciable electron heating is observed. Heating of ions is linear in time. For both tokamak and EBT slight majority heating above the collisional rate is observed due to the second harmonic heating. (author)

Technical Note: Defining cyclotron-based clinical scanning proton machines in a FLUKA Monte Carlo system.

Science.gov (United States)

Fiorini, Francesca; Schreuder, Niek; Van den Heuvel, Frank

2018-02-01

Cyclotron-based pencil beam scanning (PBS) proton machines represent nowadays the majority and most affordable choice for proton therapy facilities, however, their representation in Monte Carlo (MC) codes is more complex than passively scattered proton system- or synchrotron-based PBS machines. This is because degraders are used to decrease the energy from the cyclotron maximum energy to the desired energy, resulting in a unique spot size, divergence, and energy spread depending on the amount of degradation. This manuscript outlines a generalized methodology to characterize a cyclotron-based PBS machine in a general-purpose MC code. The code can then be used to generate clinically relevant plans starting from commercial TPS plans. The described beam is produced at the Provision Proton Therapy Center (Knoxville, TN, USA) using a cyclotron-based IBA Proteus Plus equipment. We characterized the Provision beam in the MC FLUKA using the experimental commissioning data. The code was then validated using experimental data in water phantoms for single pencil beams and larger irregular fields. Comparisons with RayStation TPS plans are also presented. Comparisons of experimental, simulated, and planned dose depositions in water plans show that same doses are calculated by both programs inside the target areas, while penumbrae differences are found at the field edges. These differences are lower for the MC, with a γ(3%-3 mm) index never below 95%. Extensive explanations on how MC codes can be adapted to simulate cyclotron-based scanning proton machines are given with the aim of using the MC as a TPS verification tool to check and improve clinical plans. For all the tested cases, we showed that dose differences with experimental data are lower for the MC than TPS, implying that the created FLUKA beam model is better able to describe the experimental beam. © 2017 The Authors. Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists

On the problem of negative dissipation of fast waves at the fundamental ion cyclotron resonance and the accuracy of absorption estimates

International Nuclear Information System (INIS)

Castejon, F.; Pavlov, S.S.; Swanson, D. G.

2002-01-01

Negative dissipation appears when ion cyclotron resonance (ICR) heating at first harmonic in a thermal plasma is estimated using some numerical schemes. The causes of the appearance of such a problem are investigated analytically and numerically in this work showing that the problem is connected with the accuracy with which the absorption coefficient at the first ICR harmonic is estimated. The corrections for the absorption estimation are presented for the case of quasiperpendicular propagation of fast wave in this frequency range. A method to solve the problem of negative dissipation is presented and, as a result, an enhancement of absorption is found for reactor-size plasmas

Relationship between BMI and depression, according to the rs16139NPY gene

Directory of Open Access Journals (Sweden)

Hamideh Pishva

2017-06-01

Full Text Available Objective: obesity and depression are likely to interact mutually which makes it unclear if obesity causes depression or it leads to obesity; and how the genotypes have a role in obesity and depression.Methods and Materials: This cross sectional study was conducted on a sample of 400 individuals from the participants in the third phase of the comprehensive Iranian Multicenter Osteoporosis Study (IMOS. Anthropometric measurements and depression were assessed. To investigate the NPY polymorphism, PCR-RFLP was used. Binary logistic regression model was employed to determine depression as the dependent factor and gene polymorphismResults: the frequency of NPY rs16139 was 6%. No significant association could be found between NPY genotypes and depression (p >0.05. Furthermore, the results suggest that those with central obesity seem an increased chance of developing depression (P=0.02.Conclusion: There is a significant relationship between obesity and depression and obesity is a possible cause of depression. Waist circumference and abdominal obesity as components of metabolic syndrome have the most important effects on depression.

Two-stream cyclotron radiative instabilities due to the marginally mirror-trapped fraction for fustion alphas in tokamaks

Energy Technology Data Exchange (ETDEWEB)

Arunasalam, V.

1995-07-01

It is shown here that the marginally mirror-trapped fraction of the newly-born fusion alpha particles in the deuterium-tritium (DT) reaction dominated tokamak plasmas can induce a two-stream cyclotron radiative instability for the fast Alfven waves propagating near the harmonics of the alpha particle cyclotron frequency {omega}{sub c{alpha}}. This can explain both the experimentally observed time behavior and the spatially localized origin of the fusion product ion cyclotron emission (ICE) in TFTR at frequencies {omega} {approx} m{omega}{sub c{alpha}}.

Two-stream cyclotron radiative instabilities due to the marginally mirror-trapped fraction for fustion alphas in tokamaks

International Nuclear Information System (INIS)

Arunasalam, V.

1995-07-01

It is shown here that the marginally mirror-trapped fraction of the newly-born fusion alpha particles in the deuterium-tritium (DT) reaction dominated tokamak plasmas can induce a two-stream cyclotron radiative instability for the fast Alfven waves propagating near the harmonics of the alpha particle cyclotron frequency ω cα . This can explain both the experimentally observed time behavior and the spatially localized origin of the fusion product ion cyclotron emission (ICE) in TFTR at frequencies ω ∼ mω cα

Role of NPY Y1 receptor on acquisition, consolidation and extinction on contextual fear conditioning: dissociation between anxiety, locomotion and non-emotional memory behavior.

Science.gov (United States)

Lach, Gilliard; de Lima, Thereza Christina Monteiro

2013-07-01

Neuropeptide Y (NPY) is the most abundant peptide in the central nervous system (CNS) and is densely localized in the brain regions involved in stress, memory, fear and anxiety. Although previous research supports a role for NPY in the mediation of rodent and human emotional behavior, there is currently a lack of information on the effects of low doses of NPY that could have a potential therapeutic advantage, minimizing side-effects such as cognition impairment or sedation. Herein, we assessed the effects of intracerebroventricular (i.c.v.) administration of low doses of NPY, and of the Y1-agonist Leu31Pro34-NPY (LP-NPY) on contextual fear conditioning (CFC), as they have no effect on unconditioned anxiety-like, locomotor activity and non-emotional memory. NPY (3 pmol) and LP-NPY (1 pmol) inhibited freezing behavior when administered in the acquisition or consolidation stages, indicating a reduction of fear. When injected in the extinction phase, only NPY inhibited freezing behavior on CFC. Pre-treatment with the Y1-antagonist BIBO3304 before NPY and LP-NPY was able to prevent the inhibition of fear responses induced by both NPY agonists. Taken together, our results demonstrate robust fear-inhibiting effects of i.c.v. injection of NPY on contextual fear conditioning in rats, a response that is mediated, at least in part, by the Y1 receptor. Moreover, these treatments were unable to change locomotor activity or to show an anxiolytic-like effect, as evaluated in an open-field and an elevated plus-maze. This specific fear reduction effect may underlie resilience systems in the CNS and has potential therapeutic relevance in PTSD. Copyright © 2013 Elsevier Inc. All rights reserved.

Trans-arterial xenotransplantation (Tx) of newborn porcine islet (NPI). A clinic trial for type I diabetes

International Nuclear Information System (INIS)

Wang Wei; Mo Zhaohui; Huang Zufa; Luo Xianming; Liu Sheng; Ye Bin; Li Bing; Liu Yingxin

2002-01-01

Objective: Liver is an important site to host transplanted islets, and implanting of islets by hepatic artery is simpler than by portal vein. Authors' study evaluated efficiency of the method and possible complication in a clinical setting. Methods: From October 1998 to June 2000, 4 type I diabetic patients received 4 x 10 6 (2 cases) and 8 x 10 6 (2 cases) of NPI through hepatic artery. Before Tx, all cases had the history with ketosis and acidosis. Exogenous insulin doses used for these cases were 25-48 units and their GHb was 9%-11%. After Tx, the NPI recipients were treated with immunosuppressants including cyclosporin 8 mg/kg for 12 months, cellcept 2 g/d for 25 days, and methylprednisolone 500 mg at 1 st day, then reduced to 50 mg for 3 days until to 10 mg for 1 month. Liver function and CD4/CD8 of the recipients were measured before and after Tx. Results: After Tx, the dose of exogenous insulin was increased to 60 mg due to methylprednisolone treatment. When methylprednisolone dose was decreased, the requirement for insulin was reduced to 32%-58% of the dose used before Tx. The reduction of required insulin for NPI recipients was proportional to the number of implanted NPI. In addition, GHb was also reduced to normal level (4%-6%) 3 months after Tx. No significant alterations of liver function and CD4 and CD8 in blood were observed after Tx. Conclusion: Trans-arterial intro-hepatic xenotransplantation of NPI is an efficient and safe therapeutic method for type I diabetes. Combination of cyclosporin, cellcept, and methylprednisolone is an effective immunosuppressive strategy for NPI xenograft transplantation

Gold nanoparticles production using reactor and cyclotron based methods in assessment of {sup 196,198}Au production yields by {sup 197}Au neutron absorption for therapeutic purposes

Energy Technology Data Exchange (ETDEWEB)

Khorshidi, Abdollah, E-mail: abkhorshidi@yahoo.com

2016-11-01

Medical nano-gold radioisotopes is produced regularly using high-flux nuclear reactors, and an accelerator-driven neutron activator can turn out higher yield of {sup 197}Au(n,γ){sup 196,198}Au reactions. Here, nano-gold production via radiative/neutron capture was investigated using irradiated Tehran Research Reactor flux and also simulated proton beam of Karaj cyclotron in Iran. {sup 197}Au nano-solution, including 20 nm shaped spherical gold and water, was irradiated under Tehran reactor flux at 2.5E + 13 n/cm{sup 2}/s for {sup 196,198}Au activity and production yield estimations. Meanwhile, the yield was examined using 30 MeV proton beam of Karaj cyclotron via simulated new neutron activator containing beryllium target, bismuth moderator around the target, and also PbF{sub 2} reflector enclosed the moderator region. Transmutation in {sup 197}Au nano-solution samples were explored at 15 and 25 cm distances from the target. The neutron flux behavior inside the water and bismuth moderators was investigated for nano-gold particles transmutation. The transport of fast neutrons inside bismuth material as heavy nuclei with a lesser lethargy can be contributed in enhanced nano-gold transmutation with long duration time than the water moderator in reactor-based method. Cyclotron-driven production of βeta-emitting radioisotopes for brachytherapy applications can complete the nano-gold production technology as a safer approach as compared to the reactor-based method. - Graphical abstract: This figure describes gold nanoparticles production via cyclotron based method. The aim of investigating is to estimate activity and saturation yield of {sup 197}Au(n,γ){sup 198}Au and {sup 197}Au(n,2n){sup 196}Au reactions using Karaj cyclotron available in Iran. The feasibility of a cyclotron-driven production of βeta-emitting radioisotopes was investigated for therapeutic applications via a new neutron activator design. - Highlights: • Nano-gold radioisotope production

Clinical significance of changes of plasma ET and NPY levels after treatment in patients with AMI

International Nuclear Information System (INIS)

Zhou Jinbao

2005-01-01

Objective: To investigate the changes of plasma ET and NPY levels in patients with AMI. Methods: Plasma ET and NPY levels were dynamically determined in 36 patients with AMI right after establishment of diagnosis and 8h, 24h, 4ph, 72h, 7d, 14d later. Levels in 35 healthy individuals were taken as control. Results: Before treatment was initiated, the levels of Et and Np in patients with AMI were significantly higher than those in controls (P <0.01). After one week of treatment, the levels dropped toward normal. Conclusion: Dynamic measurement of plasma ET and NPY levels in patients with AMI is of clinical importance. (authors)

The neuropeptides CCK and NPY and the changing view of cell-to-cell communication in the taste bud.

Science.gov (United States)

Herness, Scott; Zhao, Fang-Li

2009-07-14

The evolving view of the taste bud increasingly suggests that it operates as a complex signal processing unit. A number of neurotransmitters and neuropeptides and their corresponding receptors are now known to be expressed in subsets of taste receptor cells in the mammalian bud. These expression patterns set up hard-wired cell-to-cell communication pathways whose exact physiological roles still remain obscure. As occurs in other cellular systems, it is likely that neuropeptides are co-expressed with neurotransmitters and function as neuromodulators. Several neuropeptides have been identified in taste receptor cells including cholecystokinin (CCK), neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), and glucagon-like peptide 1 (GLP-1). Of these, CCK and NPY are the best studied. These two peptides are co-expressed in the same presynaptic cells; however, their postsynaptic actions are both divergent and antagonistic. CCK and its receptor, the CCK-1 subtype, are expressed in the same subset of taste receptor cells and the autocrine activation of these cells produces a number of excitatory physiological actions. Further, most of these cells are responsive to bitter stimuli. On the other hand, NPY and its receptor, the NPY-1 subtype, are expressed in different cells. NPY, acting in a paracrine fashion on NPY-1 receptors, results in inhibitory actions on the cell. Preliminary evidence suggests the NPY-1 receptor expressing cell co-expresses T1R3, a member of the T1R family of G-protein coupled receptors thought to be important in detection of sweet and umami stimuli. Thus the neuropeptide expressing cells co-express CCK, NPY, and CCK-1 receptor. Neuropeptides released from these cells during bitter stimulation may work in concert to both modulate the excitation of bitter-sensitive taste receptor cells while concurrently inhibiting sweet-sensitive cells. This modulatory process is similar to the phenomenon of lateral inhibition that occurs in other sensory systems.

MICHIGAN: Cyclotron conference

Energy Technology Data Exchange (ETDEWEB)

Anon.

1984-10-15

A sense of excitement was in the air as cyclotron physicists and engineers from 17 countries convened on 30 April for the opening of the Tenth International Conference on Cyclotrons and Their Applications. Some 50 years after its invention, the redoubtable cyclotron remains a topic of compelling current interest. Cyclotron experts gathered at Michigan State University's Kellogg Center to hear of latest developments, of progress and successes on new machines which had come into operation, of new projects which were underway, and of dreams which lay ahead.

Electromagnetic cyclotron harmonic waves

International Nuclear Information System (INIS)

Ohnuma, T.; Watanabe, T.; Hamamatsu, K.

1981-09-01

Electromagnetic electron cyclotron harmonic waves just below the electron cyclotron harmonics are investigated numerically and experimentally. Backward waves which are observed to propagate nearly perpendicular to the magnetic field just below the electron cyclotron frequency in a high density magnetoplasma are confirmed to be in accord with the theoretical electromagnetic cyclotron waves. (author)

MICHIGAN: Cyclotron conference

International Nuclear Information System (INIS)

Anon.

1984-01-01

A sense of excitement was in the air as cyclotron physicists and engineers from 17 countries convened on 30 April for the opening of the Tenth International Conference on Cyclotrons and Their Applications. Some 50 years after its invention, the redoubtable cyclotron remains a topic of compelling current interest. Cyclotron experts gathered at Michigan State University's Kellogg Center to hear of latest developments, of progress and successes on new machines which had come into operation, of new projects which were underway, and of dreams which lay ahead

Fast wave current drive

International Nuclear Information System (INIS)

Goree, J.; Ono, M.; Colestock, P.; Horton, R.; McNeill, D.; Park, H.

1985-07-01

Fast wave current drive is demonstrated in the Princeton ACT-I toroidal device. The fast Alfven wave, in the range of high ion-cyclotron harmonics, produced 40 A of current from 1 kW of rf power coupled into the plasma by fast wave loop antenna. This wave excites a steady current by damping on the energetic tail of the electron distribution function in the same way as lower-hybrid current drive, except that fast wave current drive is appropriate for higher plasma densities

Test and calibration of the magnetic measurement system for the Superconducting Cyclotron at LNS, Catania

International Nuclear Information System (INIS)

Giove, D.; Rossi, L.; Gmaj, P.; LoMonaco, L.; Raia, G.

1992-01-01

The apparatus for magnetic measurements before commissioning of the Superconducting Cyclotron is presented. This is a fast system designed for the systematic mapping of cyclotron fields. A search coil measures the field variation by scanning the median plane radially. The absolute value of the field is measured by NMR probes placed at the cyclotron centre and at the RF cavity holes. Accounting for dead times (coil return, drift measurement); the conservative estimate was made of measuring one full map per hour, with an azimuthal step of 1 o . A brief description of the software used and probe calibration data are included. (author) 4 refs.; 1 fig.; 1 tab

Installation and testing of a hospital-based cyclotron for radiation therapy and isotope production

International Nuclear Information System (INIS)

Almond, P.R.; Marbach, J.R.; Otte, V.A.

1983-01-01

A hospital based cyclotron is under installation at The University of Texas M.D. Anderson Hospital in Houston. This machine will be used for the production of radioactive isotopes and for the generation of neutrons for the radiotherapy treatment of cancer. It is a Cyclotron Corporation CP-42 negative proton accelerator. For neutron production the protons are transported through an isocentrically mounted beam transport system that can be rotated around the patient. The shielding requirements of this facility will be described as will the initial measurements on the characteristics of the neutron beam

Clinical significance of measurement of changes of plasma leptin and serum NPY levels after hemodialysis in patients with chronic renal failure

International Nuclear Information System (INIS)

Xia Zhengping

2010-01-01

Objective: To explore the clinical significance of changes of plasma leptin and serum NPY levels after hemodialysis in patients with chronic renal failure. Methods: Plasma leptin and serum NPY levels were measured with RIA both before and after hemodialysis in 31 patients with chronic renal failure as well as in 35 controls. Results: Before hemodialysis,plasma leptin and serum NPY levels were significantly higher in the patients than those in controls (P<0.01). After hemodialysis for 1 week the levels, though dropped markedly, still remained significantly higher than those in controls (P<0.05). Conclusion: The levels of leptin and NPY were significantly increased in patients with chronic renal failare. Hemodialysis could increase, the clearance rate of leptin and NPY and partially correct the levels with important clinical value. (authors)

Clinical significance of determination of plasma NPY levels and serum lipid profile in patients with cerebral hemorrhage and cerebral infarction

International Nuclear Information System (INIS)

Huang Fujuan; Shen Airong; Yang Yongqing

2010-01-01

Objective: To study the clinical significance of changes of plasma NPY levels and serum lipid profile in patients with cerebral hemorrhage and cerebral infarction. Methods: Plasma NPY levels (with RIA) and serum lipid profile (with biochemistry) were determined in (1) 48 patients with acute cerebral hemorrhage (2) 46 patients with acute cerebral infarction and (3) controls.Results Plasma NPY levels in both patients with cerebral hemorrhage and patients with cerebral infarction were significantly higher than those in controls (P 0.05). Conclusion: NPY played important roles in the development and pathogenesis of cerebral vascular accidents. Lipid profile changes was the basic etiological factor. (authors)

Comparative study of ion cyclotron waves at Mars, Venus and Earth

Science.gov (United States)

Wei, H. Y.; Russell, C. T.; Zhang, T. L.; Blanco-Cano, X.

2011-08-01

Ion cyclotron waves are generated in the solar wind when it picks up freshly ionized planetary exospheric ions. These waves grow from the free energy of the highly anisotropic distribution of fresh pickup ions, and are observed in the spacecraft frame with left-handed polarization and a wave frequency near the ion's gyrofrequency. At Mars and Venus and in the Earth's polar cusp, the solar wind directly interacts with the planetary exospheres. Ion cyclotron waves with many similar properties are observed in these diverse plasma environments. The ion cyclotron waves at Mars indicate its hydrogen exosphere to be extensive and asymmetric in the direction of the interplanetary electric field. The production of fast neutrals plays an important role in forming an extended exosphere in the shape and size observed. At Venus, the region of exospheric proton cyclotron wave production may be restricted to the magnetosheath. The waves observed in the solar wind at Venus appear to be largely produced by the solar-wind-Venus interaction, with some waves at higher frequencies formed near the Sun and carried outward by the solar wind to Venus. These waves have some similarity to the expected properties of exospherically produced proton pickup waves but are characterized by magnetic connection to the bow shock or by a lack of correlation with local solar wind properties respectively. Any confusion of solar derived waves with exospherically derived ion pickup waves is not an issue at Mars because the solar-produced waves are generally at much higher frequencies than the local pickup waves and the solar waves should be mostly absorbed when convected to Mars distance as the proton cyclotron frequency in the plasma frame approaches the frequency of the solar-produced waves. In the Earth's polar cusp, the wave properties of ion cyclotron waves are quite variable. Spatial gradients in the magnetic field may cause this variation as the background field changes between the regions in which

Polymorphism in NPY and IGF-I genes associate with reproductive ...

African Journals Online (AJOL)

STORAGESEVER

2009-10-05

Oct 5, 2009 ... effects of NPY and IGF-I genes on reproductive traits of chickens. Key words: ... flavor and good egg quality are accorded with Chinese consumers' taste. ... Numerous studies in mammals and more recently in teleost fish.

Effects of plasma CGRP and NPY level changes on intestinal mucosal barrier injury after scald in rats

International Nuclear Information System (INIS)

Shao Lijian; Zhu Qingxian; He Ming; Zhang Hongyan

2004-01-01

Objective: To investigate the significance of plasma CGRP and NPY levels changes immediately after scald in rats. Methods: Thirty-two rat models of 30% TBSA III degree scald were prepared. Eight animals each were sacrificed at 3, 6,12 and 24 hrs; taking blood samples for determination of plasma CGRP, NPY levels and 5 cm of ileum for pathologic study. As controls, eight animals without scald were treated in the same way. Results: Plasma CGRP levels were decreased significantly after scald, reaching bottom value at 12 hr and remained lower than those in controls at 24 hr (p 0.05). Plasma levels of CGRP were negatively correlated to plasma NPY levels (p<0.01). Ileum mucosal injuries presented as edema, congestion with necrosis and slough of epithelium were most marked at 12 hr. Conclusion: Plasma CGRP and NPY levels changed significantly after scald and were mutually negatively correlated. Post-scald intestinal mucosa barrier injuries were possibly related to the changes of levels of those vasoactive peptides

Cyclotron waves in plasma

CERN Document Server

Lominadze, D G

2013-01-01

Cyclotron Waves in Plasma is a four-chapter text that covers the basic physical concepts of the theory of cyclotron waves and cyclotron instabilities, brought about by the existence of steady or alternating plasma currents flowing perpendicular to the magnetic field.This book considers first a wide range of questions associated with the linear theory of cyclotron oscillations in equilibrium plasmas and in electron plasmas in metals and semiconductors. The next chapter deals with the parametric excitation of electron cyclotron oscillations in plasma in an alternating electric field. A chapter f

Diffusion induced by cyclotron resonance heating

International Nuclear Information System (INIS)

Riyopoulos, S.; Tajima, T.; Hatori, T.; Pfirsch, D.

1985-09-01

The wave induced particle transport during the ion cyclotron resonance heating is studied in collisionless toroidal plasmas. It is shown that the previously neglected non-conservation of the toroidal angular momentum IP/sub phi/ caused by the toroidal wave component E/sub phi/ is necessary to allow particle diffusion and yields the leading diffusive contribution. While the induced ion transport for the rf power in contemporary experiments is of the order of the neoclassical value, that of fast alpha particles is quite large if resonance is present

Application of RIA of PRA, AT II and NPY in typing and therapy of EH patients

International Nuclear Information System (INIS)

Yang Yongqing; Wang Xiaozhou; Jiang Qinian

2001-01-01

Objective: To study the typing and AT II receptor inhibitor therapy for essential hypertension (EH) patients. Methods: Plasma RA, AT II and NPY levels were measured by radioimmunoassay (RIA) in 208 Patients with EH and 100 controls; plasma NPY levels were measured in 40 EH patients before and after AT II receptor inhibitor therapy. The mean coefficient of variation for intra and inter batch-assay were less than 10% and 15% respectively. Results: In 208 EH patients plasma PRA levels were increased, normal and decreased in 17.8%, 71.6% and 10.6% respectively, while in 128 EH patients Plasma AT II levels were increased, normal and decreased in 20.3%, 64.1% and 15.6% respectively. In 69 EH Plasma NPY levels were significantly higher than those in 40 control subjects. (17 grade I EH, 137.3 +- 32.6 pg/mL; 28 grade II EH, 148.5 +- 41.1 pg/mL; 24 grade III EH, 162.4 +- 42.7 pg/mL; 40 controls, 118.5 +- 30.5 pg/mL). In 40 EH patients plasma NPY levels were decreased after AT II receptor inhibitor therapy as the blood pressure decreased. Conclusion: Typing of EH patients according to levels of plasma PRA and AT II is useful in guiding treatment. AT II receptor inhibitors are indicated in those patients with increased plasma levels and NPY levels can be used for appraisal of the treatment efficacy

[Cyclotron based nuclear science

International Nuclear Information System (INIS)

1991-08-01

This report contains descriptions of research programs carried out by Institute staff, as well as progress on new instrumentation during the period, April 1, 1990, to March 31, 1991. The K500 cyclotron and ECR source provided beam for 4140 hours during the period. The beam was actually available for experiments 1927.50 hours and 1110.50 hours was devoted to developing new beams and exploring cyclotron performance. A wide range of beams from protons to Xe with energies from 2.4 MeV/u to 60 MeV/U have been used in experiments. The highest total energy beam accelerated was 35 MeV/u 63 Cu. The ECR source, made a tremendous improvement in accelerator performance and reliability. Substantial amounts of beam time were devoted to investigations of hot nuclei, electron-positron, giant resonances, atomic effects of high velocity ion beams, astrophysics related reactions and proton and alpha bremsstrahlung. Scientific accomplishments included determination of the heat capacity of nuclei through new insight into the level densities and establishing a lower limit for electron positron resonances a factor of ten better than previous measurements. The proton spectrometer, constructed for studies of the Gamow-Teller interaction is complete, and initial physics measurements will be made in the next few months. All of the BaF 2 crystals have been delivered and acceptance tests are underway. A K=315 MDM spectrometer has been obtained from Oxford University and is scheduled for installation in Spring 1992, after removal of the K=150 Enge split pole spectrometer. Institute groups continue participation in MEGA, instrumentation projects for RHIC, and few nucleon studies at LAMPF and KEK. Reports of these activities are included

The Midwest Proton Radiation Institute project at the Indiana University Cyclotron Facility

Energy Technology Data Exchange (ETDEWEB)

Anferov, V; Broderick, B; Collins, J C; Friesel, D L; Jenner, D; Jones, W P; Katuin, J; Klein, S B; Starks, W; Self, J; Schreuder, N [IUCF, Bloomington, Indiana 47408 (United States)

2001-12-12

The IUCF cyclotrons ceased delivering particle beams for physics research and became dedicated medical proton beam accelerators in 1999. Removal of the beam lines and nuclear research facilities associated with the cyclotrons to make room for the new medical beam delivery systems was completed in October, 2000. A new achromatic beam line was completed, extending from the main stage cyclotron and ending at a temporary research platform. This beam line is being commissioned during ongoing applied research. The achromatic line will deliver 0.5 {mu}A of 205 MeV protons from which the treatment room technician may draw current at any time via fast switching, laminated magnets located at the entrances to the energy selection systems upstream of each of the treatment rooms. Three treatment rooms are planned, one containing two fixed horizontal lines and two gantry rooms. The cyclotrons will also support full time research in radiation effects, single event upset, radiation biology and pre-clinical research. This contribution describes the status of the medical construction project.

Clinical significance of measurement of changes of plasma NPY, CGRP and serum IGF-I levels in patients with acute cerebral infarction

International Nuclear Information System (INIS)

Deng Weiqun; Zhao Yushan

2007-01-01

Objective: To investigate the clinical significance of changes of plasma NPY, CGRP and serum IGF-I levels in patients with acute cerebral infarction. Methods: Plasma NPY, CGRP and serum IGF-I levels were determined with RIA in 32 patients with acute cerebral infarction both before and after treatment and 30 controls. Results: Before treatment plasma NPY levels were significantly higher (P<0.01) than those in the controls, while plasma CGRP and serum IGF-I levels were lower than those in controls (P<0.01). After treatment, plasma NPY levels decreased significantly (vs before treatment P<0.05), and plasma CGRP and serum IGF-I levels increased (P<0.05). Conclusion: Changes of plasma NPY, CGRP and serum IGF-I levels were closely related to the disease process in patients with acute cerebral infarction, determination of which was of important clinical values. (authors)

Electromagnetic waves near the proton cyclotron frequency: Stereo observations

Energy Technology Data Exchange (ETDEWEB)

Jian, L. K. [Department of Astronomy, University of Maryland, College Park, MD 20742 (United States); Wei, H. Y.; Russell, C. T. [Institute of Geophysics and Planetary Physics, University of California, Los Angeles, CA 90095 (United States); Luhmann, J. G. [Space Science Laboratory, University of California, Berkeley, CA 94720 (United States); Klecker, B. [Max-Planck-Institut für Extraterrestrische Physik, D-85741 Garching (Germany); Omidi, N. [Solana Scientific Inc., Solana Beach, CA 92075 (United States); Isenberg, P. A. [Institute for the Study of Earth, Oceans, and Space, University of New Hampshire, Durham, NH 03824 (United States); Goldstein, M. L.; Figueroa-Viñas, A. [Heliophysics Science Division, NASA Goddard Space Flight Center, MD 20771 (United States); Blanco-Cano, X., E-mail: lan.jian@nasa.gov [Instituto de Geofisica, Universidad Nacional Autónoma de México, Coyoacán D.F. (Mexico)

2014-05-10

Transverse, near-circularly polarized, parallel-propagating electromagnetic waves around the proton cyclotron frequency were found sporadically in the solar wind throughout the inner heliosphere. They could play an important role in heating and accelerating the solar wind. These low-frequency waves (LFWs) are intermittent but often occur in prolonged bursts lasting over 10 minutes, named 'LFW storms'. Through a comprehensive survey of them from Solar Terrestrial Relations Observatory A using dynamic spectral wave analysis, we have identified 241 LFW storms in 2008, present 0.9% of the time. They are left-hand (LH) or right-hand (RH) polarized in the spacecraft frame with similar characteristics, probably due to Doppler shift of the same type of waves or waves of intrinsically different polarities. In rare cases, the opposite polarities are observed closely in time or even simultaneously. Having ruled out interplanetary coronal mass ejections, shocks, energetic particles, comets, planets, and interstellar ions as LFW sources, we discuss the remaining generation scenarios: LH ion cyclotron instability driven by greater perpendicular temperature than parallel temperature or by ring-beam distribution, and RH ion fire hose instability driven by inverse temperature anisotropy or by cool ion beams. The investigation of solar wind conditions is compromised by the bias of the one-dimensional Maxwellian fit used for plasma data calibration. However, the LFW storms are preferentially detected in rarefaction regions following fast winds and when the magnetic field is radial. This preference may be related to the ion cyclotron anisotropy instability in fast wind and the minimum in damping along the radial field.

Solid targets and irradiation facilities for production of diagnostic and therapeutic radionuclides at the Debrecen cyclotron

International Nuclear Information System (INIS)

Tarkanyi, F.; Ando, L.; Szucs, Z.; Mahunka, I.; Kovacs, Z.

2000-01-01

The MGC-20E (NIIEFA, Leningrad, USSR) variable energy compact cyclotron (k=20) was installed in ATOMKI (Debrecen, Hungary) in 1985. Protons, deuterons, 3 He- and α-particles can be accelerated with currents up to 300 μA for internal irradiation and up to 50 μA for external beams. The establishment of the Cyclotron Laboratory was partly supported by the International Atomic Energy Agency. The application of the cyclotron is multipurpose: basic nuclear research, application of activation technique for analytical and wear studies, application of intense fast neutron source for agro-biological, bio-medical application and for radiation damage test of electronic components, and finally radioisotope production for medical diagnostics and for other scientific and applied fields. The cyclotron laboratory has six target rooms, a radiochemistry laboratory and a medical unit equipped with PET

Cyclotron waves in plasma

International Nuclear Information System (INIS)

Lominadse, D.G.

1975-01-01

The book deals with fundamental physical concepts of the theory of cyclotron waves and cyclotron instabilities conditioned by the presence in plasma of direct or alternating electric currents passing in it perpendicularily to a magnetic field. A great variety of problems is considered connected with the linear theory of cyclotron oscillations in equilibrium and electron plasma of metals and semiconductors. Parametric excitations of electron cyclotron oscillations of plasma in an alternating electric field are studied. Particular attention is paid to the investigation of plasma turbulence arising as a result of development of cyclotron instabilities. Experimental data are discussed and compared with theoretical results

Cyclotrons: 1978

International Nuclear Information System (INIS)

Martin, J.A.

1978-01-01

A compilation is presented of the experimental facilities of the world's cyclotrons including history and status, staff and operation, research staff, target facilities, magnet, acceleration system, vacuum system, characteristic beams, beam properties, and a plan view of the facility for each cyclotron

Ponderomotive force near cyclotron resonance

Energy Technology Data Exchange (ETDEWEB)

Kono, Mitsuo; Sanuki, Heiji

1987-01-01

The ponderomotive force, which is involved in the excitation of macroscopic behaviors of plasma caused by wave motion, plays an important role in various non-linear wave motion phenomena. In the present study, equations for the pondermotive force for plasma in a uniform magnetic field is derived using a renormalization theory which is based on the Vlasov equation. It is shown that the pondermotive force, which diverges at the cyclotron resonence point according to adiabatic approximation, can be expressed by a non-divergent equation by taking into account the instability of the cyclotron orbit due to high-order scattering caused by a wave. This is related with chaotic particle behaviors near cyclotron resonance, where the pondermotive force is small and the diffusion process prevails. It is assumed here that the amplitude of the high-frequency electric field is not large and that the broadening of cyclotron levels is smaller than the distance between the levels. A global chaos will be created if the amplitude of the electric field becomes greater to allow the broadening to exceed the distance between the levels. (Nogami, K.).

Cyclotron transitions of bound ions

Science.gov (United States)

Bezchastnov, Victor G.; Pavlov, George G.

2017-06-01

A charged particle in a magnetic field possesses discrete energy levels associated with particle rotation around the field lines. The radiative transitions between these levels are the well-known cyclotron transitions. We show that a bound complex of particles with a nonzero net charge displays analogous transitions between the states of confined motion of the entire complex in the field. The latter bound-ion cyclotron transitions are affected by a coupling between the collective and internal motions of the complex and, as a result, differ from the transitions of a "reference" bare ion with the same mass and charge. We analyze the cyclotron transitions for complex ions by including the coupling within a rigorous quantum approach. Particular attention is paid to comparison of the transition energies and oscillator strengths to those of the bare ion. Selection rules based on integrals of collective motion are derived for the bound-ion cyclotron transitions analytically, and the perturbation and coupled-channel approaches are developed to study the transitions quantitatively. Representative examples are considered and discussed for positive and negative atomic and cluster ions.

One-D full-wave description of plasma emission and absorption in the ion cyclotron range of frequency in tokamaks

International Nuclear Information System (INIS)

Fraboulet, D.; Becoulet, A.; Nguyen, F.

1998-11-01

To maintain the ignition state in a tokamak fusion reactor, a control must be performed on the population of alpha-products, and this implies the ability to diagnose those α-particles. It is studied here whether the detection of emission radiated in the ion cyclotron range of frequency be a reactor plasma can provide useful information concerning fusion products, especially concerning their density profile. It is shown that the detection of the radiation emitted by the fast alpha particles along their cyclotron motion can give access to moments of their distribution function. This requires to compute the phase of the emitted field, using a full-wave approach. Such a technique allows to set in a convenient way the inverse problem of the determination of the emitting α-particles distribution through the radiation detection. A brief analysis of the expected situation in a reactor-relevant plasma is given. In parallel, the 1-D full-wave code developed in this frame is also useful for studying the physics of Fast Wave plasma heating. It enables to take into account the mode conversion of the Fast Wave into the Ion Bernstein Wave that appears near each ion cyclotron resonance. Results show that higher order terms may significantly alter the energy partitioning, in hot plasma cases involving mode conversion heating and/or ion cyclotron high harmonics heating. (author)

Hamiltonian study of the response of a tokamak plasma to the ion cyclotron heating wave: minor heating and current generation by the fast wave

International Nuclear Information System (INIS)

Becoulet, A.

1990-06-01

The role of additional Heatings, such as the Ion Cyclotron Heating, is to raise magnetic fusion plasmas to higher temperatures, to satisfy the ignition condition. The understanding of the wave absorption mechanisms by the plasma first requires a precise description of the particle individual trajectories. The Hamiltonian mechanics, through action-angle variables, allows this description, and makes the computation of the wave-particle interaction easier. We then derive a quantitative evaluation of the intrinsic stochasticity for ionic trajectories perturbated by the fast wave. This stochasticity, combinated to the collisional effects, gives the validity domain for a quasilinear approximation of the evolution equation. This equation is then written under a variational formulation, and solved semi-analytically. Results conclude to the importance of the Hamiltonian chaos in the formation of the deeply anisotropic distribution tails, encountered in minority heating scenarios. Direct interaction of the electrons and the fast wave is similarly analysed. The influence of the various parameters (wave spectrum, magnetic configuration, frequency,...) is then examined in order to optimize this scenario of fast wave current drive in tokamaks [fr

Radiation shielding and health physics instrumentation for PET medical cyclotrons

International Nuclear Information System (INIS)

Mukherjee, B.

2002-01-01

Full text: Modern Medical Cyclotrons produce a variety of short-lived positron emitting PET radioisotopes, and as a result are the source of intense neutron and gamma radiations. Since such cyclotrons are housed within hospitals or medical clinics, there is significant potential for un-intentional exposure to staff or patients in proximity to cyclotron facilities. Consequently, the radiological hazards associated with Cyclotrons provide the impetus for an effective radiological shielding and continuous monitoring of various radiation levels in the cyclotron environment. Management of radiological hazards is of paramount importance for the safe operation of a Medical Cyclotron facility. This work summarised the methods of shielding calculations for a compact hospital based Medical Cyclotron currently operating in Canada, USA and Australia. The design principle and operational history of a real-time health physics monitoring system (Watchdog) operating at a large multi-energy Medical Cyclotron is also highlighted

Identification of minority ion cyclotron emission during radio frequency heating in the JET tokamak

International Nuclear Information System (INIS)

Cottrell, G.A.

1999-11-01

First measurements and identification of Minority Ion Cyclotron Emission (MICE) during ICRF (H)D minority heating in the JET tokamak are presented. An inner wall radiofrequency (rf) probe shows the new single MICE spectral line, downshifted from the heating, frequency and appearing ∼ 400 ms after the ICRH switch-on. The line is narrow (Δω / ω) ∼ 0.04), characterised by the ion cyclotron frequency of minority protons in the outer edge mid-plane plasma and is observed irrespective of whether single or multi-frequency ICRH is applied. Threshold conditions for MICE are: coupled RF power to the plasma P rf ≥ 4.5 MW; total fast ion energy content W fast ≥ 0.6 MJ. At the time of the rapid switch-on of MICE, the measured power loss from the energetic minority ions is ∼ 0.1 ± 0.1 MW, constituting rf . The observations are consistent with the classical evolution and population of the plasma edge with ∼ 3 MeV ICRH protons on orbits near the outboard limiters. Particle loss and energy filtering contribute to a local non-Maxwellian energetic ion distribution which is susceptible to ion cyclotron instability

Generation of plasma rotation in a tokamak by ion-cyclotron absorption of fast Alfven waves

International Nuclear Information System (INIS)

Perkins, F.W.; White, R.B.; Bonoli, P.T.; Chan, V.S.

2001-01-01

A mechanism is proposed and evaluated for driving rotation in tokamak plasmas by minority ion-cyclotron heating, even though this heating introduces negligible angular momentum. The mechanism has two elements: First, angular momentum transport is governed by a diffusion equation with a boundary condition at the separatrix. Second, Monte Carlo calculations show that ion-cyclotron energized particles will provide a torque density source which has a zero volume integral but separated positive and negative regions. With such a source, a solution of the diffusion equation predicts that ion-cyclotron heating will cause a rotational shear layer to develop. The corresponding jump in plasma rotation ΔΩ is found to be negative outwards when the ion-cyclotron surface lies on the low-field side of the magnetic axis and positive outwards with the resonance on the high-field side. The magnitude of the jump ΔΩ=(4q max WJ 2 *) (eBR 3 a 2 n e (2π) 2 ) -1 (τ M /τ E ) where |J 2 *|≅2-4 is a nondimensional rotation frequency calculated by the Monte Carlo ORBIT code [R. B. White and M. S. Chance, Phys. Fluids 27, 2455 (1984)]. For a no-slip boundary condition when the resonance lies on the low-field side of the magnetic axis, the sense of predicted axial rotation is co-current and overall agreement with experiment is good. When the resonance lies on the high-field side, the predicted rotation becomes countercurrent for a no-slip boundary while the observed rotation remains co-current. The rotational shear layer position is controllable and of sufficient magnitude to affect microinstabilities

Implementation of EPICS based vacuum control system for variable energy cyclotron centre, Kolkata

Science.gov (United States)

Roy, Anindya; Bhole, R. B.; Nandy, Partha P.; Yadav, R. C.; Pal, Sarbajit; Roy, Amitava

2015-03-01

The vacuum system of the Room Temperature (K = 130) Cyclotron of Variable Energy Cyclotron Centre is comprised of vacuum systems of main machine and Beam Transport System. The vacuum control system is upgraded to a PLC based Automated system from the initial relay based Manual system. The supervisory control of the vacuum system is implemented in Experimental Physics and Industrial Control System (EPICS). An EPICS embedded ARM based vacuum gauge controller is developed to mitigate the requirement of vendor specific gauge controller for gauges and also for seamless integration of the gauge controllers with the control system. A set of MS-Windows ActiveX components with embedded EPICS Channel Access interface are developed to build operator interfaces with less complex programming and to incorporate typical Windows feature, e.g., user authentication, file handling, better fonts, colors, mouse actions etc. into the operator interfaces. The control parameters, monitoring parameters, and system interlocks of the system are archived in MySQL based EPICS MySQL Archiver developed indigenously. In this paper, we describe the architecture, the implementation details, and the performance of the system.

Implementation of EPICS based vacuum control system for variable energy cyclotron centre, Kolkata

Energy Technology Data Exchange (ETDEWEB)

Roy, Anindya, E-mail: r-ani@vecc.gov.in; Bhole, R. B.; Nandy, Partha P.; Yadav, R. C.; Pal, Sarbajit; Roy, Amitava [Variable Energy Cyclotron Centre, 1/AF Bidhan Nagar, Kolkata 700064 (India)

2015-03-15

The vacuum system of the Room Temperature (K = 130) Cyclotron of Variable Energy Cyclotron Centre is comprised of vacuum systems of main machine and Beam Transport System. The vacuum control system is upgraded to a PLC based Automated system from the initial relay based Manual system. The supervisory control of the vacuum system is implemented in Experimental Physics and Industrial Control System (EPICS). An EPICS embedded ARM based vacuum gauge controller is developed to mitigate the requirement of vendor specific gauge controller for gauges and also for seamless integration of the gauge controllers with the control system. A set of MS-Windows ActiveX components with embedded EPICS Channel Access interface are developed to build operator interfaces with less complex programming and to incorporate typical Windows feature, e.g., user authentication, file handling, better fonts, colors, mouse actions etc. into the operator interfaces. The control parameters, monitoring parameters, and system interlocks of the system are archived in MySQL based EPICS MySQL Archiver developed indigenously. In this paper, we describe the architecture, the implementation details, and the performance of the system.

Implementation of EPICS based vacuum control system for variable energy cyclotron centre, Kolkata

International Nuclear Information System (INIS)

Roy, Anindya; Bhole, R. B.; Nandy, Partha P.; Yadav, R. C.; Pal, Sarbajit; Roy, Amitava

2015-01-01

The vacuum system of the Room Temperature (K = 130) Cyclotron of Variable Energy Cyclotron Centre is comprised of vacuum systems of main machine and Beam Transport System. The vacuum control system is upgraded to a PLC based Automated system from the initial relay based Manual system. The supervisory control of the vacuum system is implemented in Experimental Physics and Industrial Control System (EPICS). An EPICS embedded ARM based vacuum gauge controller is developed to mitigate the requirement of vendor specific gauge controller for gauges and also for seamless integration of the gauge controllers with the control system. A set of MS-Windows ActiveX components with embedded EPICS Channel Access interface are developed to build operator interfaces with less complex programming and to incorporate typical Windows feature, e.g., user authentication, file handling, better fonts, colors, mouse actions etc. into the operator interfaces. The control parameters, monitoring parameters, and system interlocks of the system are archived in MySQL based EPICS MySQL Archiver developed indigenously. In this paper, we describe the architecture, the implementation details, and the performance of the system

Clinical significance of determination of plasma leptin, NPY and serum Hcy levels in patients with chronic renal diseases

International Nuclear Information System (INIS)

Lu Zhifeng

2010-01-01

Objective: To study the relationship between progress of disease and blood levels of leptin, NPY, Hcy in patients with chronic renal diseases. Methods: Plasma leptin, NPY (with RIA) and serum Hcy (with CLIA) were determined in (1) 32 patients with chronic pyelonephritis (2) 28 patients with dibetic nephropathy (3) 30 patients with chronic renal failure and (4) 30 controls. Results: Blood levels of leptin, NPY and Hcy were slightly higher in patients with chronic pyelonephritis than those in controls but without significance (P>0.05). In patients with diabetic nephropathy, the plasma leptin and serum Hcy levels were significantly higher than those in controls (P 0.05). In patients with chronic renal failure,the blood levels of NPY (P<0.05) and leptin, Hcy (P<0.01) were all significantly higher than those in controls. Conclusion: Blood levels of these three parameters especially leptin and Hcy, were increased in patients with chronic renal diseases and the increase was most significant in advanced cases. (authors)

Cyclotrons as mass spectrometers

International Nuclear Information System (INIS)

Clark, D.J.

1984-04-01

The principles and design choices for cyclotrons as mass spectrometers are described. They are illustrated by examples of cyclotrons developed by various groups for this purpose. The use of present high energy cyclotrons for mass spectrometry is also described. 28 references, 12 figures

Cyclotron Phase-Coherent Ion Spatial Dispersion in a Non-Quadratic Trapping Potential is Responsible for FT-ICR MS at the Cyclotron Frequency

Science.gov (United States)

Nagornov, Konstantin O.; Kozhinov, Anton N.; Tsybin, Yury O.

2018-01-01

Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) at the cyclotron frequency instead of the reduced cyclotron frequency has been experimentally demonstrated using narrow aperture detection electrode (NADEL) ICR cells. Here, based on the results of SIMION simulations, we provide the initial mechanistic insights into the cyclotron frequency regime generation in FT-ICR MS. The reason for cyclotron frequency regime is found to be a new type of a collective motion of ions with a certain dispersion in the initial characteristics, such as pre-excitation ion velocities, in a highly non-quadratic trapping potential as realized in NADEL ICR cells. During ion detection, ions of the same m/z move in phase for cyclotron ion motion but out of phase for magnetron (drift) ion motion destroying signals at the fundamental and high order harmonics that comprise reduced cyclotron frequency components. After an initial magnetron motion period, ion clouds distribute into a novel type of structures - ion slabs, elliptical cylinders, or star-like structures. These structures rotate at the Larmor (half-cyclotron) frequency on a plane orthogonal to the magnetic field, inducing signals at the true cyclotron frequency on each of the narrow aperture detection electrodes. To eliminate the reduced cyclotron frequency peak upon dipolar ion detection, a number of slabs or elliptical cylinders organizing a star-like configuration are formed. In a NADEL ICR cell with quadrupolar ion detection, a single slab or an elliptical cylinder is sufficient to minimize the intensity of the reduced cyclotron frequency components, particularly the second harmonic. [Figure not available: see fulltext.

Directory of cyclotrons used for radionuclide production in Member States

International Nuclear Information System (INIS)

1998-03-01

The directory of cyclotrons used for radionuclide production is an update of the data base on cyclotrons that was compiled in 1983 by the International Atomic Energy Agency. The directory contains technical, utilization and administrative information supplied to the IAEA as of October 1997. The directory was prepared through information collected by questionnaires sent to institutions that either have a cyclotron, or that were identified to be in the process of installation of a cyclotron. The directory contains 206 entries for cyclotrons operating in 34 Member States. The largest concentration of cyclotrons for radionuclide production are located in the United States of America (66), Japan (33) and Germany (22). The largest number of cyclotrons for a single country is the United States of America. The expansion in number of cyclotrons during the last decade has been driven by the advent of advances in medical imaging instrumentation (PET, SPET and more recently 511 KeV emission tomography); introduction of user friendly compact medical cyclotrons from several companies that manufacture cyclotrons; and recent decisions that 15 O-oxygen PET studies in Japan, and 18 F-FDG PET studies in Germany are eligible for reimbursement by government or insurance companies

Directory of cyclotrons used for radionuclide production in Member States

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-03-01

The directory of cyclotrons used for radionuclide production is an update of the data base on cyclotrons that was compiled in 1983 by the International Atomic Energy Agency. The directory contains technical, utilization and administrative information supplied to the IAEA as of October 1997. The directory was prepared through information collected by questionnaires sent to institutions that either have a cyclotron, or that were identified to be in the process of installation of a cyclotron. The directory contains 206 entries for cyclotrons operating in 34 Member States. The largest concentration of cyclotrons for radionuclide production are located in the United States of America (66), Japan (33) and Germany (22). The largest number of cyclotrons for a single country is the United States of America. The expansion in number of cyclotrons during the last decade has been driven by the advent of advances in medical imaging instrumentation (PET, SPET and more recently 511 KeV emission tomography); introduction of user friendly compact medical cyclotrons from several companies that manufacture cyclotrons; and recent decisions that {sup 15}O-oxygen PET studies in Japan, and {sup 18}F-FDG PET studies in Germany are eligible for reimbursement by government or insurance companies.

Remote target removal for the Oak Ridge 86-inch Cyclotron

International Nuclear Information System (INIS)

Walls, A.A.

1982-01-01

A remotely operated target remover has been plaed in operation at the 86-Inch Cyclotron located in Oak Ridge. The system provides for the remote removal of a target from inside the cyclotron, loading it into a cask, and the removal of the cask from the 1.5 m (5-ft) shielding walls. The remote system consists of multiple electrical and pneumatically operated equipment which is designed for controlled step-by-step operation, operated with an electrical control panel, and monitored by a television system. The target remover has reduced the radiation exposures to operating personnel at the facility and has increased the effective operating time. The system is fast, requires a minimum of skill to operate, and has demonstrated both reliability and durability

Medical applications of cyclotrons

International Nuclear Information System (INIS)

Jean, R.; Fauchet, M.

1978-01-01

Isochronous cyclotrons used to accelerate different charged particles (protons, deuterons, alphas...) at variable energies, have important medical applications, for neutron teletherapy, in vivo or in vitro activation analysis or production of short-lived radioisotopes for nuclear medicine. The characteristics of the cyclotron presently available are described for these three applications (low energy 'compact' cyclotrons, cyclotrons of intermediate and high energies), and their advantages are discussed from the points of view of the medical requirements, the financial investments and the results obtained. (orig.) [de

Reversed shear Alfven eigenmode stabilization by localized electron cyclotron heating

Energy Technology Data Exchange (ETDEWEB)

Van Zeeland, M A; Hyatt, A W; Lohr, J; Petty, C C [General Atomics, PO Box 85608 San Diego, CA 92186-5608 (United States); Heidbrink, W W [University of California-Irvine, Irvine, CA 92697 (United States); Nazikian, R; Solomon, W M; Gorelenkov, N N; Kramer, G J [Princeton Plasma Physics Laboratory, Princeton, NJ 08543-0451 (United States); Austin, M E [University of Texas-Austin, Austin, TX 78712 (United States); Berk, H L [Institute for Fusion Studies, University of Texas at Austin, Austin, TX 78712 (United States); Holcomb, C T; Makowski, M A [Lawrence Livermore National Laboratory, Livermore, CA (United States); McKee, G R [University of Wisconsin-Madison, Madison, WI 53726 (United States); Sharapov, S E [Euratom/UKAEA Fusion Association, Culham, Abingdon, Oxfordshire, OX14 3DB (United Kingdom); Rhodes, T L [University of California-Los Angeles, Los Angeles, California, 90095 (United States)], E-mail: vanzeeland@fusion.gat.com

2008-03-15

Reversed shear Alfven eigenmode (RSAE) activity in DIII-D is stabilized by electron cyclotron heating (ECH) applied near the minimum of the magnetic safety factor (q{sub min}) in neutral beam heated discharges with reversed-magnetic shear. The degree of RSAE stabilization, fast ion density and the volume averaged neutron production (S{sub n}) are highly dependent on ECH deposition location relative to q{sub min}. While discharges with ECH stabilization of RSAEs have higher S{sub n} and more peaked fast ion profiles than discharges with significant RSAE activity, neutron production remains strongly reduced (up to 60% relative to TRANSP predictions assuming classical fast ion transport) even when RSAEs are stabilized.

Clinical significance of measurement of changes of serum NSE and plasma NPY levels after treatment in pediatric patients with viral encephalitis

International Nuclear Information System (INIS)

Jin Bo; Zheng Guo

2007-01-01

Objective: To explore the significance ef changes of serum NSE and plasma NPY levels after treatment in pediatric patients with viral encephalitis. Methods: Serum NSE and plasma NPY levels were measured with RIA in 32 pediatric patients with viral encephalitis both before and after treatment as well as in 30 controls. Results: Before treatment, in the patients, the serum NSE and plasma NPY levels were significantly higher than those in controls (P<0.01). After 1 month's treatment the levels dropped markedly but still remained significantly higher than those in controls (P<0.05). Conclusion: Serum NSE and plasma NPY levels changes were closely related to the progress of viral encephalitis. (authors)

Channeling experiments at IPNE Cyclotron

Energy Technology Data Exchange (ETDEWEB)

Constantin, F; Dumitru, M; Ivan, A [Cyclotron Laboratory, Institute of Atomic Physics, Institute of Physics and Nuclear Engineering, R-76900 Bucharest, P.O.Box MG-6, (Romania)

1992-01-01

Channeling experiments have been performed at the I.P.N.E Cyclotron using a 3 MeV alpha beam. A slide system cut the beam up to 5 minutes spatial resolution with a maximum 60 nA beam current on the target. The two-axis goniometer, fully computer-controlled, moves the target, a silicon wafer, with 2.5 minute resolution, while an alpha particle sensitive solid state detector, monitors the backscattered particle fluence. In the first stage, channeling appears to be a simple, fast and reliable method for precise monocrystal orientation. A reduction of the host yield by a factor of two allowed impurities and defects to be studied. (Author).

The observation of nonlinear ion cyclotron wave excitation during high-harmonic fast wave heating in the large helical device

International Nuclear Information System (INIS)

Kasahara, H.; Seki, T.; Kumazawa, R.; Saito, K.; Mutoh, T.; Kubo, S.; Shimozuma, T.; Igami, H.; Yoshimura, Y.; Takahashi, H.; Yamada, I.; Tokuzawa, T.; Ohdachi, S.; Morita, S.; Nomura, G.; Shimpo, F.; Komori, A.; Motojima, O.; Oosako, T.; Takase, Y.

2008-01-01

A wave detector, a newly designed magnetic probe, is installed in the large helical device (LHD). This wave detector is a 100-turn loop coil with electrostatic shield. Comparing a one-loop coil to this detector, this detector has roughly constant power coupling in the lower frequency range of 40 MHz, and it can easily detect magnetic wave in the frequency of a few megahertz. During high-harmonic fast wave heating, lower frequency waves (<10 MHz) were observed in the LHD for the first time, and for the power density threshold of lower frequency wave excitation (7.5 MHz) the power density of excited pumped wave (38.47 MHz) was approximately -46 dBm/Hz. These lower frequencies are kept constant for electron density and high energy particle distribution, and these lower frequency waves seem to be ion cyclotron waves caused by nonlinear wave-particle interaction, for example, parametric decay instability.

Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects.

Science.gov (United States)

Ukkola, O; Kesäniemi, Y A

2007-09-01

Neuropeptide Y (NPY) plays a central in energy homeostasis and potentially in the development of obesity-related comorbidities, like type II diabetes. As the PreproNPY Leu7Pro polymorphism probably changes the intracellular processing of the synthesized preproNPY peptide, we assessed the hypothesis that PreproNPY Leu7Pro polymorphism is a risk factor for type II diabetes, impaired glucose tolerance and hypertension. Blood pressure recordings and oral glucose tolerance test were performed in the hypertensive (n=515) and control cohorts (n=525) of our well-defined Oulu Project Elucidating Risk of Atherosclerosis (OPERA) study. The prevalence of type II diabetes was 9% (n=93). The genotypes, insulin and glucose metabolism indexes and plasma ghrelin of the subjects were determined. Pro7 allele frequencies were 5.9, 5.3 and 11.3% in the total cohort, in subjects without and with type II diabetes, respectively. The PreproNPY Pro7 carrier status was a significant risk factor for type II diabetes, and the effect remained significant after adjustment for age, sex, waist circumference and study group (odds ratio=3.02, confidence interval: 1.67-5.44 and Pghrelin levels compared to non-carriers. The PreproNPY Pro7 allele is associated with an increased risk for type II diabetes. The risk seems to be associated with a higher insulin resistance among Pro7 carriers whereas low ghrelin concentrations in Pro7 carriers are possibly a consequence of high insulin levels.

Oblique electron cyclotron emission for electron distribution studies (invited)

International Nuclear Information System (INIS)

Preische, S.; Efthimion, P.C.; Kaye, S.M.

1997-01-01

Electron cyclotron emission (ECE) at an oblique angle to the magnetic field provides a means of probing the electron distribution function both in energy and physical space through changes in and constraints on the relativistic electron cyclotron resonance condition. Diagnostics based on this Doppler shifted resonance are able to study a variety of electron distributions through changes in the location of the resonance in physical or energy space accomplished by changes in the viewing angle and frequency, and the magnetic field. For the case of observation across a changing magnetic field, such as across the tokamak midplane, the constraint on the resonance condition for real solutions to the dispersion relation can constrain the physical location of optically thin emission. A new Oblique ECE diagnostic was installed and operated on the PBX-M tokamak for the study of energetic electrons during lower hybrid current drive. It has a view 33 degree with respect to perpendicular in the tokamak midplane, receives second harmonic X-mode emission, and is constrained to receive single pass emission by SiC viewing dumps on the tokamak walls. Spatial localization of optically thin emission from superthermal electrons (50 endash 100 keV) was obtained by observation of emission upshifted from a thermal cyclotron harmonic. The localized measurements of the electron energy distribution and the superthermal density profile made by this diagnostic demonstrate its potential to study the spatial transport of energetic electrons on fast magnetohydrodynamic time scales or anomalous diffusion time scales. Oblique ECE can also be used to study electron distributions that may have a slight deviation from a Maxwellian by localizing the emission in energy space. (Abstract Truncated)

An experimental study on cyclotron-Cherenkov radiation

Energy Technology Data Exchange (ETDEWEB)

Lee, C Y; Masuzaki, M; Yoshida, H; Toyosugi, N; Kamada, K; Ando, R [Kanazawa Univ. (Japan). Department of Physics

1997-12-31

Dielectric-loaded cylindrical waveguide configurations with an injected electron beam in which the growth rate of the cyclotron-Cherenkov instability surpasses that of the Cherenkov instability were sought by numerical treatment, and one configuration of this kind was found. This configuration consists of a metallic core and an outer metallic cylinder with a dielectric liner on the inner surface. Based on the calculations, an experimental device was designed and assembled to investigate experimentally radiation due to the cyclotron-Cherenkov instability. Beam propagation in the dielectric-loaded coaxial waveguide and microwave radiation due to the cyclotron-Cherenkov instability and the Cherenkov instability were studied. (author). 6 figs., 10 refs.

Clinical relevance of determination the changes of serum cTnI, NPY and PGMP contents after treatment in patients with coronary heart diseases

International Nuclear Information System (INIS)

Ge Hengsong; Ma Chao; Wu Kaixia

2011-01-01

Objective: To explore the clinical significance of changes of serum cTnI, NPY and PGMP levels in patients with coronary heart diseases after treatment. Methods: Serum NPY, PGMP (with RIA), serum cTnI (with Biochemistry) levels were measured in 41 patients with coronary heart diseases both before and after treatment as well as in 35 normal controls. Results: Before treatment, serum cTnI, NPY and PGMP levels were significantly higher than those in controls (P 0.05), but serum PGMP level remained prominently higher (P<0.05). Conclusion: Pathogenesis and progress of CHD, might be closely related to serum cTnI, NPY and PGMP levels. (authors)

Corticotropin-releasing factor overexpression in mice abrogates sex differences in body weight, visceral fat, and food intake response to a fast and alters levels of feeding regulatory hormones.

Science.gov (United States)

Wang, Lixin; Goebel-Stengel, Miriam; Yuan, Pu-Qing; Stengel, Andreas; Taché, Yvette

2017-01-01

Corticotropin-releasing factor overexpressing (CRF-OE) male mice showed an inhibited feeding response to a fast, and lower plasma acyl ghrelin and Fos expression in the arcuate nucleus compared to wild-type (WT) mice. We investigated whether hormones and hypothalamic feeding signals are impaired in CRF-OE mice and the influence of sex. Male and female CRF-OE mice and WT littermates (4-6 months old) fed ad libitum or overnight fasted were assessed for body, adrenal glands and perigonadal fat weights, food intake, plasma hormones, blood glucose, and mRNA hypothalamic signals. Under fed conditions, compared to WT, CRF-OE mice have increased adrenal glands and perigonadal fat weight, plasma corticosterone, leptin and insulin, and hypothalamic leptin receptor and decreased plasma acyl ghrelin. Compared to male, female WT mice have lower body and perigonadal fat and plasma leptin but higher adrenal glands weights. CRF-OE mice lost these sex differences except for the adrenals. Male CRF-OE and WT mice did not differ in hypothalamic expression of neuropeptide Y (NPY) and proopiomelanocortin (POMC), while female CRF-OE compared to female WT and male CRF-OE had higher NPY mRNA levels. After fasting, female WT mice lost more body weight and ate more food than male WT, while CRF-OE mice had reduced body weight loss and inhibited food intake without sex difference. In male WT mice, fasting reduced plasma insulin and leptin and increased acyl ghrelin and corticosterone while female WT showed only a rise in corticosterone. In CRF-OE mice, fasting reduced insulin while leptin, acyl ghrelin and corticosterone were unchanged with no sex difference. Fasting blood glucose was higher in CRF-OE with female > male. In WT mice, fasting increased hypothalamic NPY expression in both sexes and decreased POMC only in males, while in CRF-OE mice, NPY did not change, and POMC decreased in males and increased in females. These data indicate that CRF-OE mice have abnormal basal and fasting

Development of an Ethernet enabled microcontroller based module for Superconducting Cyclotron ECR beam line control

International Nuclear Information System (INIS)

Chatterjee, M.; Koley, D.; Nabhiraj, P.Y.

2012-01-01

An Ethernet enabled control and data acquisition module is developed for remote control and monitoring of the ECR beam line equipment of the Superconducting Cyclotron. The PIC microcontroller based module supports multiple general purpose analog and digital inputs and outputs for interfacing with various equipments and an embedded web server. The remote monitoring and control of the equipment are achieved through the web based user interface. The user authenticated access to control parameters and module configuration parameters ensures the operational safety of the equipment under control. This module is installed in Superconducting Cyclotron ECR beam line for the control and monitoring of vacuum pumping modules, comprising of pumps, gate valves and dual vacuum gauges. The installation of these modules results in a distributed control with localised field cabling and hence better fault diagnosis. (author)

Operational experience and recent developments at the National Medical Cyclotron, Sydney

International Nuclear Information System (INIS)

Conard, E.M.; Arnott, D.W.

1996-01-01

The National Medical Cyclotron, Sydney, Australia commenced operation in mid 1991, with a mission to provide PET and SPECT radionuclides throughout Australia. The realization of the present production capacity has been synonymous with the development of the facility's industrial cyclotron (IBA Cyclone 30). The choice of cyclotron was based on the Cyclone 30's virtues as a compact, user-friendly, energy efficient cyclotron, offering the beam quality characteristic of negative ion technology. Development of the cyclotron has improved reliability and increased beam capacity, while improvements to targetry have increased production reliability. More recently, the installation and commissioning of a new solid target irradiation facility has provided much needed redundancy. This paper describes the major cyclotron and targetry developments carried out to date. (orig.)

Identification of SNPs in NPY and LEP and the association with food ...

Indian Academy of Sciences (India)

gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle ... in NPY. LEP is regulated by glucose after feeding (Mueller et al. 1998). .... cose metabolism regulates leptin secretion from cultured rat adipocytes.

Insulin Detemir Causes Lesser Weight Gain in Comparison to Insulin Glargine: Role on Hypothalamic NPY and Galanin

Directory of Open Access Journals (Sweden)

Mohammad Ishraq Zafar

2014-01-01

Full Text Available Objective. Compared with other insulin analogues, insulin detemir induces less weight gain. This study investigated whether this effect was achieved by influencing the hypothalamic appetite regulators neuropeptide Y (NPY and galanin (GAL. Methods. Type  2 diabetic rat models were established with a high-fat diet and intraperitoneal injection of STZ. All rats were divided into NC, DM, DM+DE and DM+GLA groups. Glycemic levels of all study groups were checked at study onset and after 4 weeks of insulin treatment. Food intake and body weight were monitored during treatment. After 4 weeks, the hypothalamus of rats was examined for NPY and GAL mRNA and protein expression. Results. After 4 weeks of treatment, compared with the DM+GLA group, the DM+DE group exhibited less food intake (P<0.05 and less weight gain (P<0.05, but showed similar glycemic control. The expression of hypothalamic NPY and GAL at both mRNA and protein level were significantly lower (P<0.05 in the DM+DE group. Conclusion. Insulin detemir decreased food intake in type 2 diabetic rats, which led to reduced weight gain when compared to insulin glargine treatment. This effect is likely due to downregulation of hypothalamic NPY and GAL.

Manufacture and analysis of exciter RF generator for proton cyclotron Decy-13

International Nuclear Information System (INIS)

Prajitno

2011-01-01

Exciter of the RF generator for 13 MeV proton cyclotron have been analyzed and manufactured. RF generator will be used as a source of alternating voltage accelerating of the Decy-13 cyclotron which designed by PTAPB-BATAN. Based on the basic design documents that have been made, the Decy-13 cyclotron will use 1.275 Tesla magnetic field so that the RF generator frequency when using the fourth harmonic is 77.667 MHz. One of the radio frequency signal generation technique where the output frequency is very stable and easy to set up and is currently being developed is the technique of Direct Digital Synthesizer (DDS). DDS technology is an innovative circuit architecture that allows fast and precise frequency manipulation of its output, under full digital control. Prototype of the RF generator exciter that was created using DDS type AD9851 manufactured by Analog Devices with a fundamental frequency of 30 MHz and controlled by the ATmega16 micro controller. To avoid unexpected frequency of its output, the output signal of the DDS is passed to the passive band pass filter circuit. The test results showed that the exciter output frequency range is 2 MHz with center frequency of 77.667 MHz. and stop band -3 dB. While RF power output 10 Watt require 12 V power supply with current 1,6 A. Although the exciter prototype still needs improvement but the results are as expected. (author)

Primary study on the clinical significance of measurement of epidermal growth factor (EGF) and NPY concentrations in human semen plasma

International Nuclear Information System (INIS)

Zhang Jiyun; Ning Yong

2008-01-01

Objective: To investigate the difference between the semen plasma contents of EGF and NPY in fertile and non-fertile males with the relevant sperm count and motility. Methods: Semen plasma contents of EGF and NPY were determined with RIA in 110 non-fertile males. Simultaneous semen analysis revealed (1) Group A, n=45, with normal sperm count, (2) Group B, n=34 low sperm count (0-20) x 10 6 /ml and (3) Group C n=31, with aspermia. White blood cell/HPF was examined in all the semen specimens and sperm motile rate and motility were examined in Group A specimens. Results: The semen plasma contents of EGF and NPY in non-fertile males were significantly higher than those in fertile males (P 1 x 10 6 /ml) were significantly lower than those in specimens with more white blood cells (P<0.05). Conclusion: Higher semen plasma contents of EGF and NPY might exert toxic effect on the sperms, contributing to the development of infertility. (authors)

@OceanSeaIceNPI: Positive Practice of Science Outreach via Social Media

Science.gov (United States)

Meyer, A.; Pavlov, A.; Rösel, A.; Granskog, M. A.; Gerland, S.; Hudson, S. R.; King, J.; Itkin, P.; Negrel, J.; Cohen, L.; Dodd, P. A.; de Steur, L.

2016-12-01

As researchers, we are keen to share our passion for science with the general public. We are encouraged to do so by colleagues, journalists, policy-makers and funding agencies. How can we best achieve this in a small research group without having specific resources and skills such as funding, dedicated staff, and training? How do we sustain communication on a regular basis as opposed to the limited lifetime of a specific project? The emerging platforms of social media have become powerful and inexpensive tools to communicate science for various audiences. Many research institutions and individual researchers are already advanced users of social media, but small research groups and labs remain underrepresented. A small group of oceanographers, sea ice, and atmospheric scientists at the Norwegian Polar Institute have been running their social media science outreach for two years @OceanSeaIceNPI. Here we share our successful experience of developing and maintaining a researcher-driven outreach through Instagram, Twitter and Facebook. We present our framework for sharing responsibilities within the group to maximize effectiveness. Each media channel has a target audience for which the posts are tailored. Collaboration with other online organizations and institutes is key for the growth of the channels. The @OceanSeaIceNPI posts reach more than 4000 followers on a weekly basis. If you have questions about our @OceanSeaIceNPI initiative, you can tweet them with a #ask_oceanseaicenpi hashtag anytime.

Reversed synaptic effects of hypocretin and NPY mediated by excitatory GABA-dependent synaptic activity in developing MCH neurons.

Science.gov (United States)

Li, Ying; Xu, Youfen; van den Pol, Anthony N

2013-03-01

In mature neurons, GABA is the primary inhibitory neurotransmitter. In contrast, in developing neurons, GABA exerts excitatory actions, and in some neurons GABA-mediated excitatory synaptic activity is more prevalent than glutamate-mediated excitation. Hypothalamic neuropeptides that modulate cognitive arousal and energy homeostasis, hypocretin/orexin and neuropeptide Y (NPY), evoked reversed effects on synaptic actions that were dependent on presynaptic GABA release onto melanin-concentrating hormone (MCH) neurons. MCH neurons were identified by selective green fluorescent protein (GFP) expression in transgenic mice. In adults, hypocretin increased GABA release leading to reduced excitation. In contrast, in the developing brain as studied here with analysis of miniature excitatory postsynaptic currents, paired-pulse ratios, and evoked potentials, hypocretin acted presynaptically to enhance the excitatory actions of GABA. The ability of hypocretin to enhance GABA release increases inhibition in adult neurons but paradoxically enhances excitation in developing MCH neurons. In contrast, NPY attenuation of GABA release reduced inhibition in mature neurons but enhanced inhibition during development by attenuating GABA excitation. Both hypocretin and NPY also evoked direct actions on developing MCH neurons. Hypocretin excited MCH cells by activating a sodium-calcium exchanger and by reducing potassium currents; NPY reduced activity by increasing an inwardly rectifying potassium current. These data for the first time show that both hypocretin and NPY receptors are functional presynaptically during early postnatal hypothalamic development and that both neuropeptides modulate GABA actions during development with a valence of enhanced excitation or inhibition opposite to that of the adult state, potentially allowing neuropeptide modulation of use-dependent synapse stabilization.

Phase-space resolved measurement of 2nd harmonic ion cyclotron heating using FIDA tomography at the ASDEX Upgrade tokamak

DEFF Research Database (Denmark)

Weiland, M.; Bilato, R.; Geiger, B.

2017-01-01

Recent upgrades to the FIDA (fast-ion D-alpha) diagnostic at ASDEX Upgrade allow to reconstruct the fast-ion phase space at several radial positions with decent energy and pitch resolution. These new diagnostic capabilities are applied to study the physics of 2nd harmonic ion cyclotron heating, w....... Furthermore, comparisons to other fast-ion diagnostics (neutron yield and neutral particle analyzers) are discussed....

Radiation protection of cyclotron vault with maze in PET Cyclotron Center

International Nuclear Information System (INIS)

Fueloep, Marko

2003-01-01

The PET Cyclotron center (PCC) is a complex for production, research and application of positron radiopharmaceuticals for PET (Positron Emission Tomography), which was commissioned this year (2004) in Bratislava, Slovak Republic. Positron radionuclides are produced by 18/9 MeV proton/deuteron cyclotron CYCLONE 18/9. Radiation protection of personnel and inhabitants against ionizing radiation in the PCC is solved with regard to the ICRP recommendations and Slovak regulatory system, protection rules and criteria and optimization of radiation protection. In the article comparisons of calculated and measured neutron and gamma dose equivalent rates around the CYCLONE 18/9 and at various points behind the shielding of cyclotron vault with maze are presented. Description of the CYCLONE 18/9 as a source of angular distribution of neutron energy spectra (production of 18 F was considered) was simulated by Monte Carlo code MCNPX. Code MCNP4B was used for shielding calculation of cyclotron vault with maze. Neutron energy spectra behind the shielding were measured by Bonner spectrometer. The values of neutron dose equivalent, which were calculated and measured around the CYCLONE 18/9 and at various points behind the shielding of cyclotron vault with maze, are within the range of factor 2. (authors)

A visual assistance environment for cyclotron operation

International Nuclear Information System (INIS)

Okamura, Tetsuya; Murakami, Tohru; Agematsu, Takashi; Okumura, Susumu; Arakawa, Kazuo.

1993-01-01

A computer-based operation system for a cyclotron which assists inexperienced operators has been developed. Cyclotron start-up operations require dozens of adjustable parameters to be finely tuned to maximize extracted beam current. The human interfaces of the system provide a visual environment designed to enhance beam parameter adjustments. First, the mental model of operators is analyzed. It is supposed to be composed of five partial mental models: beam behavior model, feasible setting regions model, parameter sensitivity model, parameter mutual relation model, and status map model. Next, based on these models, three visual interfaces are developed, i.e., (1) Beam trajectory is rapidly calculated and graphically displayed whenever the operators change the cyclotron parameters. (2) Feasible setting regions (FSR) of the parameters that satisfy the cyclotron's beam acceptance criteria are indicated. (3) Search traces, being a historical visual map of beam current values, are superimposed on the FSRs. Finally, to evaluate system effectiveness, the search time required to reach maximum beam current conditions was measured. In addition, system operability was evaluated using written questionnaires. Results of the experiment showed that the search time to reach specific beam conditions was reduced by approximately 65% using these interfaces. The written questionnaires survey showed the operators highly evaluate system operability. (author)

Injection and extraction for cyclotrons

International Nuclear Information System (INIS)

Heikkinen, P.

1994-01-01

External ion sources for cyclotrons are needed for polarised and heavy ions. This calls for injection systems, either radial or axial. Radial injection is also needed when a cyclotron works as a booster after another cyclotron or a linear accelerator (usually tandem). Requirements for injection differ from separated sector cyclotrons where there is plenty of room to house inflectors and/or strippers, to superconducting cyclotrons where the space is limited by a small magnet gap, and high magnetic field puts other limitations to the inflectors. Several extraction schemes are used in cyclotrons. Stripping injection is used for H - and also for heavy ions where the q/m ratio is usually doubled. For other cases, electric and magnetic deflection has to be used. To increase the turn separation before the first deflector, both resonant and non-resonant schemes are used. In this lecture, external injection systems are surveyed and some rules to thumb for injection parameters are given. Extraction schemes are also reviewed. (orig.)

Optimized choice of method for determining proliferation response of peripheral lymphocytes to mitogens in low dose irradiation with cyclotron fast neutrons

International Nuclear Information System (INIS)

Refka, Z.; Svec, M.; Aganov, P.; Svoboda, V.; Podzimek, F.

1989-01-01

Heparinized venous blood sampled from seven donors was irradiated with doses of 0.1; 0.25; 0.5; 1.0; 2.0 and 3.0 Gy of fast neutrons of a mean energy of 7.6 MeV using the U 120 M isochronous cyclotron. A non-irradiated control sample was also prepared. A lymphoblastic transformation test was conducted with both the intact and irradiated samples. The samples were cultivated in the RPMI-1640 medium with and without a mitogen addition, this in five time variants, viz., for 48, 72, 90, 96 and 120 hours. The proliferation was monitored of lymphocytes stimulated with mitogens PHA, CON-A and PWM in dependence on the time of cultivation and on the radiation dose. The dose dependent relative response was also studied of the irradiated lymphocytes. (E.J.). 8 figs., 1 tab., 18 refs

Medical cyclotron: why, where, how

International Nuclear Information System (INIS)

Scheer, Kurt; Comar, Dominique; Kellershohn, Claude

1976-01-01

Cyclotrons for medical purposes are particularly useful for the production of radioactive isotopes of elements normally constituting organic matter ( 15 O, 13 N, 11 C). The short half-life and positron emission of those elements are of great interest in medical diagnosis. Many others carrier-free radioisotopes can be produced by cyclotrons. Three categories of cyclotrons are mentioned. Desk top cyclotron only adapted to the production of short-lived radioisotopes in a hospital; low energy and average energy cyclotrons which require well-entrained personnel for their operation and are best adapted to the production of radioelements on a regional or even national scale. Examples relative to the interest of short-lived radioisotopes in lung and brain investigations and tumor detection are given

Cyclotrons for isotope production

International Nuclear Information System (INIS)

Milton, B.F.; Stevenson, N.R.

1995-06-01

Cyclotrons continue to be efficient accelerators for radioisotope production. In recent years, developments in the accelerator technology have greatly increased the practical beam current in these machines while also improving the overall system reliability. These developments combined with the development of new isotopes for medicine and industry, and a retiring of older machines indicates a strong future for commercial cyclotrons. In this paper we will survey recent developments in the areas of cyclotron technology, and isotope production, as they relate to the new generation of commercial cyclotrons. We will also discuss the possibility of systems capable of extracted energies up to 100 MeV and extracted beam currents of up to 2.0 mA. (author). 6 refs., 2 tabs., 3 figs

Production and definition of a fast neutron beam for medical use

International Nuclear Information System (INIS)

Tran, D.T.

1979-01-01

A review is made on the nuclear reactions which could be used for fast neutrons production by means of charged particles accelerated from cyclotrons. The following reactions are considered: 7 Li(p,n), 7 Li(d,n); 9 Be(p,n), 9 Be(d,n); D(d,n). These reactions are examined in view of application in fast neutron therapy. Clinical criteria are taken into account for selection of the most interesting reactions for which a study is carried out in more details. Alternative profiles of cyclotron are then depicted and compared. Their respective advantages and drawbacks are discussed [fr

The effects of electron cyclotron heating and current drive on toroidal Alfvén eigenmodes in tokamak plasmas

Science.gov (United States)

Sharapov, S. E.; Garcia-Munoz, M.; Van Zeeland, M. A.; Bobkov, B.; Classen, I. G. J.; Ferreira, J.; Figueiredo, A.; Fitzgerald, M.; Galdon-Quiroga, J.; Gallart, D.; Geiger, B.; Gonzalez-Martin, J.; Johnson, T.; Lauber, P.; Mantsinen, M.; Nabais, F.; Nikolaeva, V.; Rodriguez-Ramos, M.; Sanchis-Sanchez, L.; Schneider, P. A.; Snicker, A.; Vallejos, P.; the AUG Team; the EUROfusion MST1 Team

2018-01-01

Dedicated studies performed for toroidal Alfvén eigenmodes (TAEs) in ASDEX-Upgrade (AUG) discharges with monotonic q-profiles have shown that electron cyclotron resonance heating (ECRH) can make TAEs more unstable. In these AUG discharges, energetic ions driving TAEs were obtained by ion cyclotron resonance heating (ICRH). It was found that off-axis ECRH facilitated TAE instability, with TAEs appearing and disappearing on timescales of a few milliseconds when the ECRH power was switched on and off. On-axis ECRH had a much weaker effect on TAEs, and in AUG discharges performed with co- and counter-current electron cyclotron current drive (ECCD), the effects of ECCD were found to be similar to those of ECRH. Fast ion distributions produced by ICRH were computed with the PION and SELFO codes. A significant increase in T e caused by ECRH applied off-axis is found to increase the fast ion slowing-down time and fast ion pressure causing a significant increase in the TAE drive by ICRH-accelerated ions. TAE stability calculations show that the rise in T e causes also an increase in TAE radiative damping and thermal ion Landau damping, but to a lesser extent than the fast ion drive. As a result of the competition between larger drive and damping effects caused by ECRH, TAEs become more unstable. It is concluded, that although ECRH effects on AE stability in present-day experiments may be quite significant, they are determined by the changes in the plasma profiles and are not particularly ECRH specific.

Transition region, coronal heating and the fast solar wind

Science.gov (United States)

Li, Xing

2003-07-01

It is assumed that magnetic flux tubes are strongly concentrated at the boundaries of supergranule convection cells. A power law spectrum of high frequency Alfvén waves with a spectral index -1 originating from the sun is assumed to supply all the energy needed to energize the plasma flowing in such magnetic flux tubes. At the high frequency end, the waves are eroded by ions due to ion cyclotron resonance. The magnetic flux concentration is essential since it allows a sufficiently strong energy flux to be carried by high frequency ion cyclotron waves and these waves can be readily released at the coronal base by cyclotron resonance. The main results are: 1. The waves are capable of creating a steep transition region, a hot corona and a fast solar wind if both the wave frequency is high enough and the magnetic flux concentration is sufficiently strong in the boundaries of the supergranule convection zone. 2. By primarily heating alpha particles only, it is possible to produce a steep transition region, a hot corona and a fast solar wind. Coulomb coupling plays a key role in transferring the thermal energy of alpha particles to protons and electrons at the corona base. The electron thermal conduction then does the remaining job to create a sharp transition region. 3. Plasma species (even ions) may already partially lose thermal equilibrium in the transition region, and minor ions may already be faster than protons at the very base of the corona. 4. The model predicts high temperature alpha particles (Talpha ~ 2 x 107 K) and low proton temperatures (Tp solar radii, suggesting that hydrogen Lyman lines observed by UVCS above coronal holes may be primarily broadened by Alfvén waves in this range.

Fourier Transform Ion Cyclotron Resonance Mass Spectrometry at the Cyclotron Frequency.

Science.gov (United States)

Nagornov, Konstantin O; Kozhinov, Anton N; Tsybin, Yury O

2017-04-01

The phenomenon of ion cyclotron resonance allows for determining mass-to-charge ratio, m/z, of an ensemble of ions by means of measurements of their cyclotron frequency, ω c . In Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), the ω c quantity is usually unavailable for direct measurements: the resonant state is located close to the reduced cyclotron frequency (ω + ), whereas the ω c and the corresponding m/z values may be calculated via theoretical derivation from an experimental estimate of the ω + quantity. Here, we describe an experimental observation of a new resonant state, which is located close to the ω c frequency and is established because of azimuthally-dependent trapping electric fields of the recently developed ICR cells with narrow aperture detection electrodes. We show that in mass spectra, peaks close to ω + frequencies can be reduced to negligible levels relative to peaks close to ω c frequencies. Due to reduced errors with which the ω c quantity is obtained, the new resonance provides a means of cyclotron frequency measurements with precision greater than that achieved when ω + frequency peaks are employed. The described phenomenon may be considered for a development into an FT-ICR MS technology with increased mass accuracy for applications in basic research, life, and environmental sciences. Graphical Abstract ᅟ.

Development of HM12 cyclotron for PET

International Nuclear Information System (INIS)

Morita, Takuzo; Kawama, Tetsuo; Fujii, Kazuo

2000-01-01

In Japan, there are at present more than 30 PET (Positron Emission Tomography) facilities. The movements of medical insurance application to the PET diagnosis using [ 18 F] FDG (2-[ 18 F]-fluoro-2-deoxy-glucose) by the Ministry of Health and Welfare are being enhanced by PET related people. Therefore, more clinical centers using PET system are expected to be built in the near future. HM12 cyclotron was developed to meet such market demands for PET, and the prototype machine has been rent to Cyclotron Radio Isotope Center (CYRIC) of Tohoku University since Oct. 1998 for their use of clinical research with positron emitters like 11 C, 13 N, 15 O and 18 F. We got many technical data of HM12 Cyclotron on the clinical base. The data was enough to establish the reliability of HM12 system operation under the clinical condition. The first commercial product of HM12 Cyclotron was delivered to National Cancer Center in March 2000. The final performance test will be finished by the end of June 2000. (author)

Survey on radionuclide producing using cyclotron method in Malaysia

International Nuclear Information System (INIS)

Mohd Fadli Mohammad Noh

2008-01-01

This research discuss about basic design and systems of medical cyclotron that Malaysia currently have, its applications in radionuclide production and upcoming technologies of cyclotron. Surveys have been carried out on cyclotron facilities at Hospital Putrajaya and Wijaya International Medical Center, WIMC as well as reactor facility at Malaysia Nuclear Agency. The sources in this research also involves on-line and library searches. Information obtained are recorded, categorized, synthesized and discussed. systems of cyclotron of Hospital Putrajaya are further discussed in details. Based from the surveys carried out, it is found out that cyclotron facilities both in Hospital Putrajaya and WIMC only produce ( 18 F)FDG with radioactivity of 18 F produced in 2007 are 16479 mCi and 92546 mCi respectively. Survey also revealed that radioisotope production at Nuclear Malaysia has had its operation been ceased. A new radiopharmaceutical, namely CHOL is suggested to be synthesized by both facilities as a new PET tracer. Latest developments concerning technologies of cyclotron as well as other accelerators such as laser for future medical accelerator, prospect of boron neutron capture and the potential of hadron therapy in Malaysia are discussed here. Radioisotope production in Malaysia is expected to keep booming in future due to increase in usage of PET techniques and the construction of more compact, easy to handle and less costly cyclotrons. (author)

Advances in superconducting cyclotrons at MSU

International Nuclear Information System (INIS)

Blosser, H.; Antaya, T.; Au, R.

1987-01-01

Intensive work on superconducting cyclotrons began at MSU in late 1973 (a brief earlier study had occurred in the early 1960's) and continues vigorously at present. One large cyclotron, the ''K500'', has been operating for a number of years, a second, the ''K800'', is nearing completion, the first operating tests of its magnet having occurred at the time of the previous conference, and a third, the ''medical cyclotron'', is now also nearing completion with first operation of its magnet expected just after the present conference. These cyclotrons like other superconducting cyclotrons are all dramatically smaller than comparable room temperature machines; overall weight is typically about 1/20th of that of room temperature cyclotrons of the same energy. This large reduction in the quantities of materials is partially offset by added complexity, but finally, a net overall cost savings of 50 to 70 % typically results; as a consequence the superconducting cyclotron is widely viewed as the cyclotron of the future. The thirteen years of experience at MSU involving three of these cyclotrons, together with much important work at other laboratories, gives a rather clear view of the advantages and disadvantages of various design approaches including by now a rather significant period of long term evaluation. This paper reviews highlights of this program. (author)

Leptin, NPY, Melatonin and Zinc Levels in Experimental Hypothyroidism and Hyperthyroidism: The Relation to Zinc.

Science.gov (United States)

Baltaci, Abdulkerim Kasım; Mogulkoc, Rasim

2017-06-01

Since zinc mediates the effects of many hormones or is found in the structure of numerous hormone receptors, zinc deficiency leads to various functional impairments in the hormone balance. And also thyroid hormones have important activity on metabolism and feeding. NPY and leptin are affective on food intake and regulation of appetite. The present study is conducted to determine how zinc supplementation and deficiency affect thyroid hormones (free and total T3 and T4), melatonin, leptin, and NPY levels in thyroid dysfunction in rats. The experiment groups in the study were formed as follows: Control (C); Hypothyroidism (PTU); Hypothyroidism+Zinc (PTU+Zn); Hypothyroidism+Zinc deficient; Hyperthyroidism (H); Hyperthyroidism+Zinc (H+Zn); and Hyperthyroidism+Zinc deficient. Thyroid hormone parameters (FT 3 , FT 4 , TT 3 , and TT 4 ) were found to be reduced in hypothyroidism groups and elevated in the hyperthyroidism groups. Melatonin values increased in hyperthyroidism and decreased in hypothyroidism. Leptin and NPY levels both increased in hypo- and hyperthyroidism. Zinc levels, on the other hand, decreased in hypothyroidism and increased in hyperthyroidism. Zinc supplementation, particularly when thyroid function is impaired, has been demonstrated to markedly prevent these changes.

Medical cyclotron facilities

International Nuclear Information System (INIS)

1984-09-01

This report examines the separate proposals from the Austin Hospital and the Australian Atomic Energy Commission for a medical cyclotron facility. The proponents have argued that a cyclotron facility would benefit Australia in areas of patient care, availability and export of radioisotopes, and medical research. Positron emission tomography (PET) and neutron beam therapy are also examined

Development of Medical Cyclotron in KIRAMS

International Nuclear Information System (INIS)

Chai, Jong Seo; Jung, In Su; An, Dong Hyun

2005-01-01

This paper is presented on the development and status of medical cyclotron at the Korea Institute of Radiological and Medical Sciences (KIRAMS) at present. We have developed medical cyclotron which is KIRAMS-13. And the improvement of KIRAMS-13 is presented. Furthermore, the design of new cyclotrons, such as KIRAMS-5 and KIRAMS-30 cyclotron, are presented, and R and D studies for future plan of heavy ion accelerator are discussed

All-magnetic extraction for cyclotron beam reacceleration

Science.gov (United States)

Hudson, E.D.; Mallory, M.L.

1975-07-22

An isochronous cyclotron can be modified to provide an initial electron stripping stage, a complete acceleration of the stripped ions through the cyclotron to a first energy state, means for returning the ions to an intermediate cyclotron orbit through a second stripping stage, further acceleration of the now higher energy stripped ions through the cyclotron to their final energy, and final extraction of the ions from the cyclotron. (auth)

Trends in cyclotrons for radionuclide production

International Nuclear Information System (INIS)

Vera Ruiz, H.; Lambrecht, R.M.

1999-01-01

The IAEA recently concluded a worldwide survey of the cyclotrons used for radionuclide production. Most of the institutions responded to the questionnaire. The responses identified technical, utilisation and administrative information for 206 cyclotrons. Compiled data includes the characteristics, performance and popularity of each of the different commercial cyclotrons. Over 20 cyclotrons are scheduled for installation in 1998. The expansion in the number of cyclotron installations during the last decade was driven by the advent of advances in medical imaging instrumentation (namely, positron emission tomography (PET), and more recently by 511 KeV emission tomography); introduction of user friendly compact medical cyclotrons; and recent governmental decisions that permit reimbursement for cyclotron radiopharmaceutical studies by the government or insurance companies. The priorities for the production of clinical, commercial and research radionuclides were identified. The emphasis is on radionuclides used for medical diagnosis with SPET (e.g. 123 I, 201 Tl) and PET (e.g. 11 C, 13 N, 15 O, 18 F) radiopharmaceuticals, and for individualized patient radiation treatment planning (e.g. 64 Cu, 86 Y, 124 I) with PET. There is an emerging trend to advance the cyclotron as an alternative method to nuclear reactors for the production of neutron-rich radionuclides (e.g. 64 Cu, 103 Pd, 186 Re) needed for therapeutic applications. (authors)

Promotional Model: A New Direction for National Program in Immunization (NPI) and Oral Rehydration Therapy (ORT) in Nigeria

OpenAIRE

P.EKERETE, Paulinus

2000-01-01

The National Program on Immunization (NPI), formerly known as the Expanded Program on Immunization (EPI) and Oral Rehydration Therapy (ORT), were relaunched in1984 after the problems of vaccine supply have been corrected. The NPI aimed to protect children against six childhood killer disease and ORT, to remedy dehydration. In order to achieve these objectives, Partner-in-Health strategy was set up to educate, convince and motivate mothers, pregnant women and community to accept the programme....

Stability and nonlinear dynamics of gyrotrons at cyclotron harmonics

International Nuclear Information System (INIS)

Saraph, G.P.; Nusinovich, G.S.; Antonsen, T.M. Jr.; Levush, B.

1992-01-01

Gyrotrons operating at higher harmonics of the cyclotron frequency can overcome the frequency limitations caused by achievable strength of the magnetic field. However, the excitation of modes at the fundamental frequency exhibit a major problem for stable operation of harmonic gyrotron at high power with high efficiency. Therefore the issues of stability of gyrotron operation at the cyclotron harmonics and nonlinear dynamics of mode interaction are of great importance. The results of the authors stability analysis and multimode simulation are presented here. A detailed nonlinear theory of steady state single mode operation at cyclotron harmonics has been presented previously, taking into account beam-wave coupling and nonlinear gain function at cyclotron harmonics. A set of equations describing low gain regime interaction of modes resonant at different cyclotron harmonics was studied before. The multifrequency time-dependent nonlinear analysis presented here is based on previous gyrotron studies and beam-wave interaction at cyclotron harmonics. The authors have determined the parameter space for stable single mode operation at the second harmonic. The nonlinear dynamics of mode evolution and mode interaction for a harmonic gyrotron is presented. A new nonlinear effect in which the parasite at the fundamental harmonic helps excite the operating mode at the second harmonic has been demonstrated

A mobile superconducting cyclotron for PET and neutron radiography

International Nuclear Information System (INIS)

Griffiths, R.

1988-01-01

The report addresses the development of a mobile superconducting cyclotron for PET (positron emission tomography) and neutron radiography. Proposals for an ultralight cyclotron were made by Finlan et al., who suggested a novel technique of utilising a superconducting magnet with RF acceleration and iron sectors contained within the room temperature bore of the magnet. Detailed design of a cyclotron based on this concept has progressed well at Oxford Instruments. The main design priorities were to minimise the weight and power consumption of the cyclotron. The cyclotron required a large amount of shielding to reduce either radiation background levels or stray magnetic field. Thus low background levels of radiation and magnetic field are key design criteria. The superconducting magnet has a mean field of 2.35 Tesla and a room temperature bore diameter of 500 mm. Three pairs of profiled iron sectors placed in the center of the warm bore of the magnet provide an azimuthally varying magnetic field. This permits the use of high beam currents with low background. A novel technique is incorporated to reduce the stray magnetic field and radiation from the cyclotron. The RF system consists of three pairs of resonators mounted within the warm bore of the magnet between the iron sectors. (Nogami, K.)

Modular beam diagnostics instrument design for Cyclotrons

International Nuclear Information System (INIS)

Chaddha, N.; Bhole, R.B.; Sahoo, S.; Nandy, P.P.; Pal, S.

2012-01-01

The Cyclotrons at VECC, Kolkata i.e. Room Temperature Cyclotron (RTC) and Superconducting Cyclotron (SCC) comprise of internal and external Beam Diagnostic systems. These systems provide the beam developer with position, intensity, beam profile, a visual impression of the size and shape of ion beam, and operational control over diagnostic components like 3-finger probe, Beam Viewer probe, Deflector probe, Faraday cup, X-Y slit, Beam viewer etc. Automation of these components was initially done using customised modules for individual sub-system. An expansion of this facility and various levels of complexity demand modular design to cater easy modification and upgradation. The overall requirements are analysed and modular cards are developed based on basic functionalities like valve operation, probe/slit/viewer control, position read-out, Interlock, aperture control of beam line and communication. A 32-bit Advanced RISC Machine (ARM) based card with embedded EPICS is chosen as the master controller and FPGA/microcontroller is used for functional modules. The paper gives a comprehensive description of all modules and their integration with the control system. (author)

Modelling third harmonic ion cyclotron acceleration of deuterium beams for JET fusion product studies experiments

DEFF Research Database (Denmark)

Schneider, M.; Johnson, T.; Dumont, R.

2016-01-01

Recent JET experiments have been dedicated to the studies of fusion reactions between deuterium (D) and Helium-3 (3He) ions using neutral beam injection (NBI) in synergy with third harmonic ion cyclotron radio-frequency heating (ICRH) of the beam. This scenario generates a fast ion deuterium tail...... enhancing DD and D3He fusion reactions. Modelling and measuring the fast deuterium tail accurately is essential for quantifying the fusion products. This paper presents the modelling of the D distribution function resulting from the NBI+ICRF heating scheme, reinforced by a comparison with dedicated JET fast...

Theoretical and experimental study of modes associated to ion cyclotron heating on TFR

International Nuclear Information System (INIS)

Pignol, L.

1985-05-01

In this work, the ion cyclotron wave evolution is followed thanks to a coherent scattering device using carbon dioxide laser radiation. A theoretical part presents the dispersion equation that obey the waves excited in the plasma by antenna emitting ion cyclotron frequency. Then measurements given by the diagnostic are given. Fast and slow waves evidenced theoretically, are experimentally observed. Two simple theoretical models allow to extract physical quantities characteristics of the two modes. These two modes are followed along the radial coordinate of the tore and their behavior through the hybrid curve is studied. measured spectra shape is shown to confirm the described numerical code validity. Time study of the slow wave shows of internal relaxation phenomenon of plasma [fr

Computer design of a compact cyclotron

International Nuclear Information System (INIS)

Bing Wang; Huanfeng Hao; Qinggao Yao; Jinquan Zhang; Mingtao Song; Vorozhtsov, S.B.; Smirnov, V.L.; Hongwei Zhao

2011-01-01

Here we present results of the computer design of the structural elements of a compact cyclotron by the example of HITFiL cyclotron selected as the driving accelerator that is under construction at the Institute of Modern Physics (Lanzhou, China). In the article a complex approach to modeling of the compact cyclotron, including calculation of electromagnetic fields of the structural elements and beam dynamics calculations, is described. The existing design data on the axial injection, magnetic, acceleration and extraction systems of the cyclotron are used as a starting point in the simulation. Some of the upgrades of the cyclotron structural elements were proposed, which led to substantial improvement of the beam quality and transmission

Robust high-yield ~1 TBq production of cyclotron based sodium [99mTc]pertechnetate.

Science.gov (United States)

Andersson, J D; Thomas, B; Selivanova, S V; Berthelette, E; Wilson, J S; McEwan, A J B; Gagnon, K

2018-03-02

This paper presents the irradiation and processing of high-current 100 Mo targets at the University of Alberta (UofA) in a GMP compliant setting. For purpose of comparison with a second production facility, additional studies at Centre Hospitalier Universitaire de Sherbrooke (CHUS) are also described. More than 70% of today's diagnostic radiopharmaceuticals are based on 99m Tc, however the conventional supply chain for obtaining 99m Tc is fragile. The aim of this work was to demonstrate reliable high yield production and processing of 99m Tc with medium-energy, high-current, cyclotrons. We used two cyclotrons (TR-24, Advanced Cyclotron Systems, Inc) for irradiations with 22 MeV or 24 MeV incident energy and 400 μA current up to a maximum of 6 h. The irradiated 100 Mo was dissolved using peroxide, basified using ammonium carbonate, and purified using a PEG-based solid phase extraction technique. High-yield productions with 22 MeV (400 μA, 6 h) yielded an average isolated [ 99m Tc]TcO 4 - yield of 878 GBq ± 99 GBq (23.7 Ci ± 2.7 Ci) decay corrected to EOB, n = 8 (isolated saturation yield: 4.36 ± 0.49 GBq/μA). Irradiations with 24 MeV (400 μA, 6 h) resulted in an average isolated [ 99m Tc]TcO 4 - yield of 993 GBq ± 100 GBq (26.8 Ci ± 2.7 Ci) decay corrected to EOB, n = 7 (isolated saturation yield: 4.97 ± 0.50 GBq/μA). These yields corresponds to 600-700 GBq (16-19 Ci) of [ 99m Tc]TcO 4 - at release (i.e. 3 hour post-EOB). For all tested batches, the QC results were within the recently published specifications in the European Pharmacopoeia. Reliable near-TBq production yields for 99m Tc can be obtained using medium-energy cyclotrons. This work presents evidence that medium-energy high-current cyclotrons can provide high yields of [ 99m Tc]TcO 4 - with radionuclidic impurities levels within the specifications of the existing European Pharmacopoeia monograph, indicating that this

Association of Neuropeptide-Y (NPY) and Interleukin-1beta (IL1B), Genotype-Phenotype Correlation and Plasma Lipids with Type-II Diabetes.

Science.gov (United States)

Patel, Roma; Dwivedi, Mitesh; Mansuri, Mohmmad Shoab; Ansarullah; Laddha, Naresh C; Thakker, Ami; Ramachandran, A V; Begum, Rasheedunnisa

2016-01-01

Neuropeptide Y (NPY) is known to play a role in the regulation of satiety, energy balance, body weight, and insulin release. Interleukin-1beta (IL1B) has been associated with loss of beta-cell mass in type-II diabetes (TIID). The present study attempts to investigate the association of NPY exon2 +1128 T/C (Leu7Pro; rs16139), NPY promoter -399 T/C (rs16147) and IL1B -511 C/T (rs16944) polymorphisms with TIID and their correlation with plasma lipid levels, BMI, and IL1B transcript levels. PCR-RFLP was used for genotyping these polymorphisms in a case-control study involving 558 TIID patients and 1085 healthy age-matched controls from Gujarat. Linkage disequilibrium and haplotype analysis of the NPY polymorphic sites were performed to assess their association with TIID. IL1B transcript levels in PBMCs were also assessed in 108 controls and 101 patients using real-time PCR. Our results show significant association of both structural and promoter polymorphisms of NPY (p<0.0001 and p<0.0001 respectively) in patients with TIID. However, the IL1B C/T polymorphism did not show any association (p = 0.3797) with TIID patients. Haplotype analysis revealed more frequent association of CC and CT haplotypes (p = 3.34 x 10-5, p = 6.04 x 10-9) in diabetics compared to controls and increased the risk of diabetes by 3.02 and 2.088 respectively. Transcript levels of IL1B were significantly higher (p<0.0001) in patients as compared to controls. Genotype-phenotype correlation of IL1B polymorphism did not show any association with its higher transcript levels. In addition, NPY +1128 T/C polymorphism was found to be associated with increased plasma LDL levels (p = 0.01). The present study provides an evidence for a strong correlation between structural and promoter polymorphisms of NPY gene and upregulation of IL1B transcript levels with susceptibility to TIID and altering the lipid metabolism in Gujarat population.

Startup work on Inshas cyclotron

International Nuclear Information System (INIS)

Vorogushin, M.F.; Strokach, A.P.; Shikhov, V.Ya.; Galchuk, A.V.; Soliman, A.N.; El-Abyad, M.; Comsan, M.N.H.; Saleh, Z.A.; Azzam, A.N.

2001-01-01

Startup works on the MGC-20 variable energy cyclotron in the Inshas Nuclear Research Center (Egypt) are described. The cyclotron is intended for acceleration of hydrogen and helium ions in a wide energy range (for protons - from 5 to 20 MeV). Main units of the cyclotron and results of computer experimental acceleration of protons to 18 MeV are described. The prospects of furthers investigations are presented [ru

Cyclotrons in developing countries

International Nuclear Information System (INIS)

Vera Ruiz, Hernan

2004-01-01

Cyclotron accelerators are prolific sources of charged particle for the production of radionuclides and have become an essential tool in the practice of modern nuclear medicine by providing reliable radiotracers for SPECT and PET studies. In a recent survey conducted by the IAEA in 2001, the growth in the number of cyclotron facilities installed in laboratories and hospitals in developed as well as developing countries was recorded. This trend, which started in the late 70's, continues in the present time also and all indications are that it will continue in the next five to ten years. The reasons for this growth are several: technology involved has become more user or 'hospital friendly', third party reimbursement for several clinical studies based on F-18 PET radiopharmaceuticals at least in some of the advanced countries started in 1998 and above all, the clear irrefutable and demonstrable conclusion of the positive cost/benefit outcomes of PET studies in the field of oncology to a lesser degree, thus far, for cardiology and neurology. It is however recognizable that the overall financial cost of the technology, which comprises the premises to house the facility, the cyclotron accelerator, the corresponding radiochemistry and quality control equipment and the PET cameras can be nevertheless an expensive proposition that requires careful advance planning. This fact is even more relevant when the facility is planned for installation in a developing country, which, frequently, in addition to having a lack of sufficient financial resources, do have shortage of qualified human resources to efficiently run the facility. In spite of the above, it is fact that more and more public as well as private organizations in the developing countries are setting up cyclotron/PET programmes or are seriously considering the installation of such a facility

Ion source and injection line for high intensity medical cyclotron

Science.gov (United States)

Jia, XianLu; Guan, Fengping; Yao, Hongjuan; Zhang, TianJue; Yang, Jianjun; Song, Guofang; Ge, Tao; Qin, Jiuchang

2014-02-01

A 14 MeV high intensity compact cyclotron, CYCIAE-14, was built at China Institute of Atomic Energy (CIAE). An injection system based on the external H- ion source was used on CYCIAE-14 so as to provide high intensity beam, while most positron emission tomography cyclotrons adopt internal ion source. A beam intensity of 100 μA/14 MeV was extracted from the cyclotron with a small multi-cusp H- ion source (CIAE-CH-I type) and a short injection line, which the H- ion source of 3 mA/25 keV H- beam with emittance of 0.3π mm mrad and the injection line of with only 1.2 m from the extraction of ion source to the medial plane of the cyclotron. To increase the extracted beam intensity of the cyclotron, a new ion source (CIAE-CH-II type) of 9.1 mA was used, with maximum of 500 μA was achieved from the cyclotron. The design and test results of the ion source and injection line optimized for high intensity acceleration will be given in this paper.

Improving cancer treatment with cyclotron produced radionuclides. Progress report

Energy Technology Data Exchange (ETDEWEB)

Larson, S.M.; Finn, R.D.

1993-11-01

This report describes our continuing long term goal of promoting nuclear medicine applications by improving the scientific basis for tumor diagnosis, treatment and treatment follow-up based on the use of cyclotron produced radiotracers in oncology. The program includes 3 interactive components: Radiochemistry/Cyclotron; Pharmacology; and Immunology. An essential strategy is as follows: novel radionuclides and radiotracers developed in the Radiochemistry/Cyclotron section will be employed in the Pharmacology and Immunology sections during the next year. The development of novel radionuclides and tracers is of course useful in and of itself, but their utility is greatly enhanced by the interaction with the immunology and pharmacology components of the program.

Correlations of serum levels of TG with leptin and other related factors (L-1, NPY adiponectin) in patients with hyperlipidaemia

International Nuclear Information System (INIS)

Wang Donghong; Yu Ping; Wei Jingjun

2007-01-01

Objective: To study the changes and correlations of serum levels of triglyeride (TG), leptin, L -1, neuropeptide Y (NPY) and adiponectin in patients with hypertriglyceridemia (HTG). Methods: Serum levels of TG, leptin, L-1, NPY and adiponectin in 54 patients with HTG and 55 controls were measured with radioimmunoassay (RIA). Results: The serum levels of TG, Leptin, L -1 and NPY in patients with HTG [ (3.46 ± 1.14) mmol/L, (10.56 ±3.79) μg/L, (0.40 ± 0.18) μg/L, (115.89 ± 24.56) μg/L, respectively] were significantly higher than those in controls [ (1.26 ± 0.30) mmol/L, (5.66 ± 2.01) μg/L, (0.22 ± 0.09) μg/L, (95.21 ± 16.85) μg/L, respectively] P < 0.01 in all. But serum levels of adiponectin in patients with HTG (8.98 ± 3.51μg/L) was significantly lower than those in controls [(13.21 ± 9.46) μg/L, P < 0.01]. There were significantly positive correlations between serum TG levels and serum levels of leptin (r = 0.576, P < 0.05). There were also significantly positive correlations between serum leptin levels and serum levels of L-1 and NPY (r = 0.582; r = 0.479, respectively, P < 0.05). Conclusion: There was close relationship between increase in serum TG level and changes of serum levels of leptin, L-1, NPY, adiponectin. Neural-endocrine-immune system participated in fatty metabolism and could result in HTG. (authors)

Techniques for calculations with nPI effective actions

Directory of Open Access Journals (Sweden)

Carrington M.E.

2015-01-01

Full Text Available We consider a symmetric scalar theory with quartic coupling in 2- and 3- dimensions and compare the self-consistent 4-point vertex obtained from the 4PI effective action with the Bethe-Salpeter 4-vertex from 2PI effective action. We show that when the coupling is large the contributions from the higher order effective action are large. We also show that one can solve the 2PI equations of motion in 4-dimensions, without introducing counter-terms, using a renormalization group method. This method provides a promising starting point to study the renormalization of higher order nPI theories.

Adjustment guidance for cyclotron by real-time display of feasible setting regions

International Nuclear Information System (INIS)

Okamura, Tetsuya; Murakami, Tohru

1990-01-01

A computer aided operation system for start-up of cyclotron is being developed in order to support operators who, through their experiences and intuition, adjust dozens of components to maximize extracted beam current. This paper describes a guidance method using real-time display of feasible setting regions of adjustment parameters. It is a function of the beam adjustment support system. The followings are the key points of this paper. (1) It is proposed that a cyclotron can be modeled as a series of mapping of beam condition. In this model, the adjustment is consider to be a searching process for a mapping which maps the beam condition into the acceptance of cyclotron. (2) The searching process is formulated as a nonlinear minimization problem. In order to solve this problem, a fast search algorithm composed of a line search method (golden section search) and an image processing method (border following) is developed. The solutions are the feasible setting regions. (3) A human interface which displays feasible setting regions and a search history is realized for the beam adjustment support system It enables that the operators and the computers cooperate the operation of beam adjustment. (author)

The Medical Cyclotron Facility in RMC, Parel, BARC

International Nuclear Information System (INIS)

Gopalakrishna, Arjun; Banerjee, Sharmila

2017-01-01

The Medical Cyclotron Facility in Radiation Medicine Centre (RMC) is the first one of its kind, installed in 2002. "1"8F based radiotracers are produced in this facility on a routine basis for Positron Emission Tomography (PET), of in-house patients, as well as for supply to other nuclear medicine centers in Mumbai as well as Pune. The facility consists of the following sub parts - Cyclotron and support equipment; Radiochemistry synthesis laboratory; Quality control (QC) laboratory

Effects of Dietary Acute Tryptophan Depletion (ATD) on NPY Serum Levels in Healthy Adult Humans Whilst Controlling for Methionine Supply—A Pilot Study

Science.gov (United States)

Wong, Janice W. Y.; Morandini, Hugo A. E.; Dingerkus, Vita L. S.; Gaber, Tilman J.; Runions, Kevin C.; Mahfouda, Simone; Helmbold, Katrin; Bubenzer-Busch, Sarah; Koenemann, Rebecca; Stewart, Richard M.; Zepf, Florian D.

2018-01-01

Central nervous serotonin (5-HT) can influence behaviour and neuropsychiatric disorders. Evidence from animal models suggest that lowered levels of neuropeptide Y (NPY) may have similar effects, although it is currently unknown whether decreased central nervous 5-HT impact NPY concentrations. Given that the production of NPY is dependent on the essential amino acid methionine (MET), it is imperative to account for the presence of MET in such investigations. Hence, this study sought to examine the effects of acute tryptophan depletion (ATD; a dietary procedure that temporarily lowers central nervous 5-HT synthesis) on serum concentrations of NPY, whilst using the potential renal acid load indicator (PRAL) to control for levels of MET. In a double-blind repeated measures design, 24 adult humans randomly received an AA-load lacking in TRP (ATD) on one occasion, and a balanced control mixture with TRP (BAL) on a second occasion, both with a PRAL of nearly 47.3 mEq of MET. Blood samples were obtained at 90, 180, and 240 min after each of the AA challenges. ATD, and therefore, diminished substrate availability for brain 5-HT synthesis did not lead to significant changes in serum NPY concentrations over time, compared to BAL, under an acute acidotic stimulus. PMID:29751614

Radiation shielding analysis of medical cyclotron at Radiation Medicine Centre, Parel

International Nuclear Information System (INIS)

Gathibandhe, M.V.; Agrawal, R.A.; Utge, C.G.

2003-01-01

Full text: PET (Positron Emission Tomography) is a diagnostic method to obtain 3-D functional images of the distribution of radio-nuclides introduced in the human body as tracers for specific biological processes. Tracers are produced by bombardment of different target nuclides by protons and deuterons of high energy produced in the cyclotron. A Wipro-GE medical cyclotron was installed in the basement of RMC, Parel. Shielding around the cyclotron is provided in the form of borated concrete walls of required thickness to limit dose rates to design values as per AERB criteria. The roof of the cyclotron room is made of heavy concrete. Entry in to the room is through a maze. Shielding analysis for the cyclotron room has been carried out using computer code ANISN. The maze has been analyzed using code MCNP. Based on the analysis carried out additional shielding was recommended to meet the design requirements. The paper discusses the shielding analysis carried out for the cyclotron room and the maze. Dose rate estimated at various locations are highlighted

Numerical analysis on the synergy between electron cyclotron current drive and lower hybrid current drive in tokamak plasmas

International Nuclear Information System (INIS)

Chen, S Y; Hong, B B; Liu, Y; Lu, W; Huang, J; Tang, C J; Ding, X T; Zhang, X J; Hu, Y J

2012-01-01

The synergy between electron cyclotron current drive (ECCD) and lower hybrid current drive (LHCD) is investigated numerically with the parameters of the HL-2A tokamak. Based on the understanding of the synergy mechanisms, a high current driven efficiency or a desired radial current profile can be achieved through properly matching the parameters of ECCD and LHCD due to the flexibility of ECCD. Meanwhile, it is found that the total current driven by the electron cyclotron wave (ECW) and the lower hybrid wave (LHW) simultaneously can be smaller than the sum of the currents driven by the ECW and LHW separately, when the power of the ECW is much larger than the LHW power. One of the reasons leading to this phenomenon (referred to as negative synergy in this context) is that fast current-carrying electrons tend to be trapped, when the perpendicular velocity driven by the ECW is large and the parallel velocity decided by the LHW is correspondingly small. (paper)

Modelling of non-thermal electron cyclotron emission during ECRH

International Nuclear Information System (INIS)

Tribaldos, V.; Krivenski, V.

1990-01-01

The existence of suprathermal electrons during Electron Cyclotron Resonance Heating experiments in tokamaks is today a well established fact. At low densities the creation of large non-thermal electron tails affects the temperature profile measurements obtained by 2 nd harmonic, X-mode, low-field side, electron cyclotron emission. At higher densities suprathermal electrons can be detected by high-field side emission. In electron cyclotron current drive experiments a high energy suprathermal tail, asymmetric in v, is observed. Non-Maxwellian electron distribution functions are also typically observed during lower-hybrid current drive experiments. Fast electrons have been observed during ionic heating by neutral beams as well. Two distinct approaches are currently used in the interpretation of the experimental results: simple analytical models which reproduce some of the expected non-Maxwellian characteristics of the electron distribution function are employed to get a qualitative picture of the phenomena; sophisticated numerical Fokker-Planck calculations give the electron distribution function from which the emission spectra are computed. No algorithm is known to solve the inverse problem, i.e. to compute the electron distribution function from the emitted spectra. The proposed methods all relay on the basic assumption that the electron distribution function has a given functional dependence on a limited number of free parameters, which are then 'measured' by best fitting the experimental results. Here we discuss the legitimacy of this procedure. (author) 7 refs., 5 figs

Fast wave current drive in DIII-D

International Nuclear Information System (INIS)

Petty, C.C.; Callis, R.W.; Chiu, S.C.; deGrassie, J.S.; Forest, C.B.; Freeman, R.L.; Gohil, P.; Harvey, R.W.; Ikezi, H.; Lin-Liu, Y.-R.

1995-02-01

The non-inductive current drive from fast Alfven waves launched by a directional four-element antenna was measured in the DIII-D tokamak. The fast wave frequency (60 MHz) was eight times the deuterium cyclotron frequency at the plasma center. An array of rf pickup loops at several locations around the torus was used to verify the directivity of the four-element antenna. Complete non-inductive current drive was achieved using a combination of fast wave current drive (FWCD) and electron cyclotron current drive (ECCD) in discharges for which the total plasma current was inductively ramped down from 400 to 170 kA. For discharges with steady plasma current, up to 110 kA of FWCD was inferred from an analysis of the loop voltage, with a maximum non-inductive current (FWCD, ECCD, and bootstrap) of 195 out of 310 kA. The FWCD efficiency increased linearly with central electron temperature. For low current discharges, the FWCD efficiency was degraded due to incomplete fast wave damping. The experimental FWCD was found to agree with predictions from the CURRAY ray-tracing code only when a parasitic loss of 4% per pass was included in the modeling along with multiple pass damping

Analytic descriptions of ion cyclotron absorption

International Nuclear Information System (INIS)

Bers, A.; Francis, G.; Fuchs, V.; Lashmore-Davies, C.N.; Ram, A.K.

1987-05-01

Analysis of energy propagation and absorption in ion-cyclotron heating of tokamak plasmas has relied on numerical solutions of fourth (and sixth) order differential equations for slab models of the plasma (poloidal) cross section. Realistic two-dimensional and fully toroidal geometry analyses would become quite unwieldy. It is shown here that the analysis of the slab model can be simplified considerably. A first-order differential equation is shown to describe the transmission coefficient for the fast wave, and it is solved analytically. A second order differential equation is shown to adequately describe both transmission and reflection. Conditions for ion absorption or mode conversion are derived. Including toroidal effects in propagation, conditions for electron absorption on the mode-converted ion-Bernstein waves are also described analytically

Dynamic effects on cyclotron scattering in pulsar accretion columns

International Nuclear Information System (INIS)

Brainerd, J.J.; Meszaros, P.

1991-01-01

A resonant scattering model for photon reprocessing in a pulsar accretion column is presented. The accretion column is optically thin to Thomson scattering and optically thick to resonant scattering at the cyclotron frequency. Radiation from the neutron star surface propagates freely through the column until the photon energy equals the local cyclotron frequency, at which point the radiation is scattered, much of it back toward the star. The radiation pressure in this regime is insufficient to stop the infall. Some of the scattered radiation heats the stellar surface around the base of the column, which adds a softer component to the spectrum. The partial blocking by the accretion column of X-rays from the surface produces a fan beam emission pattern. X-rays above the surface cyclotron frequency freely escape and are characterized by a pencil beam. Gravitational light bending produces a pencil beam pattern of column-scattered radiation in the antipodal direction, resulting in a strongly angle-dependent cyclotron feature. 31 refs

Risk assessment of 30 MeV cyclotron facilities

Energy Technology Data Exchange (ETDEWEB)

Jeong, Gyo Seong; Lee, Jin Woo [Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup (Korea, Republic of); Kim, Chong Yeal [Dept. of Radiation Science and Technology, Chonbuk National University, Jeonju (Korea, Republic of)

2017-03-15

A cyclotron is a kind of particle accelerator that produces a beam of charged particles for the production of medical, industrial, and research radioisotopes. More than 30 cyclotrons are operated in Korea to produce 18F, an FDG synthesis at hospitals. A 30-MeV cyclotron was installed at ARTI (Advanced Radiation Technology Institute, KAERI) mainly for research regarding isotope production. In this study, we analyze and estimate the items of risk such as the problems in the main components of the cyclotron, the loss of radioactive materials, the leakage of coolant, and the malfunction of utilities, fres and earthquakes. To estimate the occurrence frequency in an accident risk assessment, five levels, i.e., Almost certain, Likely, Possible, Unlikely, and Rare, are applied. The accident consequence level is classified under four grades based on the annual permissible dose for radiation workers and the public in the nuclear safety law. The analysis of the accident effect is focused on the radioactive contamination caused by radioisotope leakage and radioactive material leakage of a ventilation filter due to a free. To analyze the risks, Occupation Safety and Health Acts is applied. In addition, action plans against an accident were prepared after a deep discussion among relevant researchers. In this acts, we will search for hazard and introduce the risk assessment for the research 30-MeV cyclotron facilities of ARTI.

Risk assessment of 30 MeV cyclotron facilities

International Nuclear Information System (INIS)

Jeong, Gyo Seong; Lee, Jin Woo; Kim, Chong Yeal

2017-01-01

A cyclotron is a kind of particle accelerator that produces a beam of charged particles for the production of medical, industrial, and research radioisotopes. More than 30 cyclotrons are operated in Korea to produce 18F, an FDG synthesis at hospitals. A 30-MeV cyclotron was installed at ARTI (Advanced Radiation Technology Institute, KAERI) mainly for research regarding isotope production. In this study, we analyze and estimate the items of risk such as the problems in the main components of the cyclotron, the loss of radioactive materials, the leakage of coolant, and the malfunction of utilities, fres and earthquakes. To estimate the occurrence frequency in an accident risk assessment, five levels, i.e., Almost certain, Likely, Possible, Unlikely, and Rare, are applied. The accident consequence level is classified under four grades based on the annual permissible dose for radiation workers and the public in the nuclear safety law. The analysis of the accident effect is focused on the radioactive contamination caused by radioisotope leakage and radioactive material leakage of a ventilation filter due to a free. To analyze the risks, Occupation Safety and Health Acts is applied. In addition, action plans against an accident were prepared after a deep discussion among relevant researchers. In this acts, we will search for hazard and introduce the risk assessment for the research 30-MeV cyclotron facilities of ARTI

Leptin, neuropeptide Y (NPY), melatonin and zinc levels in experimental hypothyroidism and hyperthyroidism: relation with melatonin and the pineal gland.

Science.gov (United States)

Baltaci, Abdulkerim Kasım; Mogulkoc, Rasim

2018-03-02

Background Melatonin, an important neurohormone released from the pineal gland, is generally accepted to exercise an inhibitor effect on the thyroid gland. Zinc mediates the effects of many hormones and is found in the structure of numerous hormone receptors. Aim The present study aims to examine the effect of melatonin supplementation and pinealectomy on leptin, neuropeptide Y (NPY), melatonin and zinc levels in rats with hypothyroidism and hyperthyroidism. Methods This study was performed on the 70 male rats. Experimental animals in the study were grouped as follows: control (C); hypothyroidism (PTU); hypothyroidism + melatonin (PTU + M); hypothyroidism + pinealectomy (PTU + Pnx); hyperthyroidism (H); hyperthyroidism + melatonin (H + M) and hyperthyroidism + pinealectomy (H + Pnx). Blood samples collected at the end of 4-week procedures were analyzed to determine melatonin, leptin, NPY and zinc levels. Results It was found that thyroid parameters thyroid stimulating hormone (TSH), free triiodthyronine (FT3), free thyroxine (FT4), total T3 (TT3) and total T4 (TT4) decreased in hypothyroidism groups and increased in the groups with hyperthyroidism. The changes in these hormones remained unaffected by melatonin supplementation and pinealectomy. Melatonin levels rose in hyperthyroidism and fell in hypothyroidism. Leptin and NPY levels increased in both hypothyroidism and hyperthyroidism. Zinc levels, on the other hand, decreased in hypothyroidism and pinealectomy, but increased in hyperthyroidism. Conclusion The results of the study demonstrate that hypothyroidism and hyperthyroidism affect leptin, NPY, melatonin and zinc values in different ways in rats. However, melatonin supplementation and pinealectomy do not have any significant influence on the changes occurring in leptin, NPY and zinc levels in thyroid dysfunction.

A line-of-sight electron cyclotron emission receiver for electron cyclotron resonance heating feedback control of tearing modes

DEFF Research Database (Denmark)

Oosterbeek, J.W.; Bürger, A.; Westerhof, E.

2008-01-01

An electron cyclotron emission (ECE) receiver inside the electron cyclotron resonance heating (ECRH) transmission line has been brought into operation. The ECE is extracted by placing a quartz plate acting as a Fabry-Perot interferometer under an angle inside the electron cyclotron wave (ECW) bea...

Validation of computational methods for treatment planning of fast-neutron therapy using activation foil techniques

International Nuclear Information System (INIS)

Nigg, D.W.; Wemple, C.A.; Hartwell, J.K.; Harker, Y.D.; Venhuizen, J.R.; Risler, R.

1997-12-01

A closed-form direct method for unfolding neutron spectra from foil activation data is presented. The method is applied to measurements of the free-field neutron spectrum produced by the proton-cyclotron-based fast-neutron radiotherapy facility at the University of Washington (UW) School of Medicine. The results compare favorably with theoretical expectations based on an a-priori calculational model of the target and neutron beamline configuration of the UW facility

Origins of the many NPY-family receptors in mammals

DEFF Research Database (Denmark)

Larhammar, D; Wraith, A; Berglund, M M

2001-01-01

The NPY system has a multitude of effects and is particularly well known for its role in appetite regulation. We have found that the five presently known receptors in mammals arose very early in vertebrate evolution before the appearance of jawed vertebrates 400 million years ago. The genes Y(1), Y....... These observations pertain to the discussion whether ligands or receptors tend to appear first in evolution. The roles of Y(1) and Y(5) in feeding may differ between species demonstrating the importance of performing functional studies in additional mammals to mouse and rat....

Proliferative hypothalamic neurospheres express NPY, AGRP, POMC, CART and Orexin-A and differentiate to functional neurons.

Directory of Open Access Journals (Sweden)

Lígia Sousa-Ferreira

Full Text Available Some pathological conditions with feeding pattern alterations, including obesity and Huntington disease (HD are associated with hypothalamic dysfunction and neuronal cell death. Additionally, the hypothalamus is a neurogenic region with the constitutive capacity to generate new cells of neuronal lineage, in adult rodents. The aim of the present work was to evaluate the expression of feeding-related neuropeptides in hypothalamic progenitor cells and their capacity to differentiate to functional neurons which have been described to be affected by hypothalamic dysfunction. Our study shows that hypothalamic progenitor cells from rat embryos grow as floating neurospheres and express the feeding-related neuropeptides Neuropeptide Y (NPY, Agouti-related Protein (AGRP, Pro-OpioMelanocortin (POMC, Cocaine-and-Amphetamine Responsive Transcript (CART and Orexin-A/Hypocretin-1. Moreover the relative mRNA expression of NPY and POMC increases during the expansion of hypothalamic neurospheres in proliferative conditions.Mature neurons were obtained from the differentiation of hypothalamic progenitor cells including NPY, AGRP, POMC, CART and Orexin-A positive neurons. Furthermore the relative mRNA expression of NPY, CART and Orexin-A increases after the differentiation of hypothalamic neurospheres. Similarly to the adult hypothalamic neurons the neurospheres-derived neurons express the glutamate transporter EAAT3. The orexigenic and anorexigenic phenotype of these neurons was identified by functional response to ghrelin and leptin hormones, respectively. This work demonstrates the presence of appetite-related neuropeptides in hypothalamic progenitor cells and neurons obtained from the differentiation of hypothalamic neurospheres, including the neuronal phenotypes that have been described by others as being affected by hypothalamic neurodegeneration. These in vitro models can be used to study hypothalamic progenitor cells aiming a therapeutic intervention to

A conceptual design of high-temperature superconducting isochronous cyclotron magnet

International Nuclear Information System (INIS)

Jiao, F.; Tang, Y.; Li, J.; Ren, L.; Shi, J.

2011-01-01

A design of High-temperature superconducting (HTS) isochronous cyclotron magnet is proposed. The maximum magnetic field of cyclotron main magnet reaches 3 T. Laying the HTS coil aboard the magnetic pole will raise the availability of the magnetic Field. Super-iron structure can provide a high uniformity and high gradient magnetic field. Super-iron structure can raise the availability of the HTS materials. Along with the development of High-temperature superconducting (HTS) materials, the technology of HTS magnet is becoming increasingly important in the Cyclotron, which catches growing numbers of scholars' attentions. Based on the analysis of the problems met in the process of marrying superconducting materials with ferromagnetic materials, this article proposes a design of HTS isochronous cyclotron magnet. The process of optimization of magnet and the methods of realizing target parameters are introduced after taking finite element software as analyzing tools.

Method and apparatus for ion cyclotron spectrometry

Science.gov (United States)

Dahl, David A [Idaho Falls, ID; Scott, Jill R [Idaho Falls, ID; McJunkin, Timothy R [Idaho Falls, ID

2010-08-17

An ion cyclotron spectrometer may include a vacuum chamber that extends at least along a z-axis and means for producing a magnetic field within the vacuum chamber so that a magnetic field vector is generally parallel to the z-axis. The ion cyclotron spectrometer may also include means for producing a trapping electric field within the vacuum chamber that includes at least a first section that induces a first magnetron effect that increases a cyclotron frequency of an ion and at least a second section that induces a second magnetron effect that decreases the cyclotron frequency of an ion. The cyclotron frequency changes induced by the first and second magnetron effects substantially cancel one another so that an ion traversing the at least first and second sections will experience no net change in cyclotron frequency.

Commercial compact cyclotrons in the 90's

International Nuclear Information System (INIS)

Milton, B.F.

1995-09-01

Cyclotrons continue to be efficient accelerators for radio-isotope production. In recent years, developments in the accelerator technology have greatly increased the practical beam current in these machines while also improving the overall system reliability. These developments combined with the development of new isotopes for medicine and industry, and a retiring of older machines indicate a strong future for commercial cyclotrons. In this paper we will survey recent developments in the areas of cyclotron technology, as they relate to the new generation of commercial cyclotrons. Design criteria for the different types of commercial cyclotrons will be presented, with reference to those demands that differ from those in a research oriented cyclotron project. We will also discuss the possibility of systems designed for higher energies and capable of extracted beam currents of up to 2.0 mA. (author)

Commercial compact cyclotrons in the 90's

International Nuclear Information System (INIS)

Milton, B.F.

1995-09-01

Cyclotrons continue to be efficient accelerators for radio-isotope production. In recent years, developments in the accelerator technology have greatly increased the practical beam current in these machines while also improving the overall system reliability. These developments combined with the development of new isotopes for medicine and industry, and a retiring of older machines indicate a strong future for commercial cyclotrons. In this paper the authors will survey recent developments in the areas of cyclotron technology, as they relate to the new generation of commercial cyclotrons. Design criteria for the different types of commercial cyclotrons will be presented, with reference to those demands that differ from those in a research oriented cyclotron project. The authors also discuss the possibility of systems designed for higher energies and capable of extracted beam currents of up to 2.0 mA

Ion-cyclotron-resonance- and Fourier-transform-ion-cyclotron-resonance spectroscopy: technology and application

International Nuclear Information System (INIS)

Luederwald, I.

1977-01-01

Instrumentation and technology of Ion-Cyclotron-Resonance and Fourier-Transform-Ion-Cyclotron-Resonance Spectroscopy are described. The method can be applied to studies of ion/molecule reactions in gas phase, to obtain thermodynamic data as gas phase acidity or basicity, proton and electron affinity, and to establish reaction mechanisms and ion structures. (orig.) [de

Nuclear exportin receptor CAS regulates the NPI-1-mediated nuclear import of HIV-1 Vpr.

Directory of Open Access Journals (Sweden)

Eri Takeda

Full Text Available Vpr, an accessory protein of human immunodeficiency virus type 1, is a multifunctional protein that plays an important role in viral replication. We have previously shown that the region between residues 17 and 74 of Vpr (Vpr(N17C74 contained a bona fide nuclear localization signal and it is targeted Vpr(N17C74 to the nuclear envelope and then imported into the nucleus by importin α (Impα alone. The interaction between Impα and Vpr is important not only for the nuclear import of Vpr but also for HIV-1 replication in macrophages; however, it was unclear whether full-length Vpr enters the nucleus in a manner similar to Vpr(N17C74. This study investigated the nuclear import of full-length Vpr using the three typical Impα isoforms, Rch1, Qip1 and NPI-1, and revealed that full-length Vpr is selectively imported by NPI-1, but not Rch1 and Qip1, after it makes contact with the perinuclear region in digitonin-permeabilized cells. A binding assay using the three Impα isoforms showed that Vpr bound preferentially to the ninth armadillo repeat (ARM region (which is also essential for the binding of CAS, the export receptor for Impα in all three isoforms. Comparison of biochemical binding affinities between Vpr and the Impα isoforms using surface plasmon resonance analysis demonstrated almost identical values for the binding of Vpr to the full-length isoforms and to their C-terminal domains. By contrast, the data showed that, in the presence of CAS, Vpr was released from the Vpr/NPI-1 complex but was not released from Rch1 or Qip1. Finally, the NPI-1-mediated nuclear import of Vpr was greatly reduced in semi-intact CAS knocked-down cells and was recovered by the addition of exogenous CAS. This report is the first to show the requirement for and the regulation of CAS in the functioning of the Vpr-Impα complex.

Developing the smallest possible medical cyclotron

CERN Multimedia

Katarina Anthony

2011-01-01

Imagine a portable medical cyclotron operated in a conventional radioactive facility at a hospital. Imagine a nurse or technician switching it on and producing isotopes at the patient’s bedside. Sounds like science fiction? Think again.   CERN has teamed up with Spain’s national scientific research centre (CIEMAT) to develop an avant-garde cyclotron to be used for Positron Emission Tomography (PET). “We plan to make a cyclotron that doesn't need an insulated building or ‘vault’: a cyclotron small enough to fit inside a hospital lift,” explains Jose Manuel Perez, who is leading the CIEMAT/CERN collaboration. “It will be the smallest possible medical cyclotron for single patient dose production and will dramatically reduce costs for hospitals.” While PET technology has transformed imaging techniques, many of its medical benefits have remained confined to highly specialised hospitals. “Studies have foun...

Role of PPARα in the Control of Torpor through FGF21-NPY Pathway: From Circadian Clock to Seasonal Change in Mammals

Directory of Open Access Journals (Sweden)

Norio Ishida

2009-01-01

Full Text Available In nature, hibernating animals encounter fasting, cold temperature and short day seasonally. Torpor is a state of decreased physiological activity in an animal, usually characterized by a reduced body temperature and rate of metabolism to adapt such a severe environment. Ablation of the central clock synchronizer, the suprachiasmatic nucleus in brain, abolishes torpor, a hibernation-like state, implicating the circadian clock involved in this seasonal change. Biologists knows well the energy source of daily heterotherms/hibernators changed from glucose to lipids in winter. Here we review several lines of evidence of a master transcriptional regulator in lipid catabolism, PPARα, in the control of torpor through FGF21-NPY pathway. This indicate the importance of circadian—and photoperiod—regulation of PPARα to tell seasons in our body.

A real-time positron monitor for the estimation of stack effluent releases from PET medical cyclotron facilities

International Nuclear Information System (INIS)

Mukherjee, Bhaskar.

2002-01-01

Large activities of short-lived positron emitting radiopharmaceuticals are routinely manufactured by modern Medical Cyclotron facilities for positron emission tomography (PET) applications. During radiochemical processing, a substantial fraction of the volatile positron emitting radiopharmaceuticals are released into the atmosphere. An inexpensive, fast response positron detector using a simple positron-annihilation chamber has been developed for real-time assessment of the stack release of positron emitting effluents at the Australian National Medical Cyclotron. The positron detector was calibrated by using a 3.0 ml (1.50 MBq) aliquot of 18 FDG and interfaced to an industrial standard datalogger for the real-time acquisition of stack release data

Medical cyclotron basic concepts and its applications

International Nuclear Information System (INIS)

Kumar, Rajeev; Sonkawade, R.G.

2012-01-01

More than 3000 nuclides are known, of which approximately 2700 are radioactive, and rest are stable. The majority of radionuclides are artificially produced in the reactor and cyclotron. In a cyclotron, Charge particle such as proton, Deuteron, á (Alpha) particle, 3 He particles and so forth are accelerated in circular paths within the Dees under vacuum by means of an electromagnetic field. These accelerated particles can possess few KeV to several BeV of kinetic energy depending on the design of the cyclotron. At our setup we have an 11 MeV dual beam multi target cyclotron which is capable producing 11 C, 13 N, 15 O, 18 F and 2 F radioisotopes and all have been successfully produced and tested in our lab. Earlier cyclotrons were the best source of high-energy beams for nuclear physics experiments; several cyclotrons are still in use for this type of research. Cyclotrons can be used to treat cancer. Ion beams from cyclotrons can be used, as in proton therapy. The positron emitting isotopes are suitable for PET imaging. As discussed we are producing mainly Carbon-11, Nitrogen-13, Oxygen-15, and Fluorine-18: These are positron emitters used in PET for studying brain physiology and pathology, in particular for localizing epileptic focus, and in dementia, psychiatry and neuropharmacology studies. So these are having significant role in diagnosis of Oncological, Neurological and Cardiological disorder. More than ninety percent we are producing 18 F in FDG. 18 F in FDG (Flouro-Deoxy-glucose) has become very important in detection of cancers and the monitoring of progress in their treatment, using PET. Medical cyclotron is complex equipment requiring delicate handling by highly trained personnel. The aim of this article is to highlight few finer aspects of Medical cyclotron operation, including precautions for safety and smooth functioning of this sophisticated equipment. (author)

20 years Rossendorf cyclotron

International Nuclear Information System (INIS)

1978-08-01

On the occasion of the 20th anniversary of initiating of the Rossendorf cyclotron accounts are given of most important works and results in the field of accelerator engineering and utilization of this machine. The reports show the trend of development and actual spectrum of application. The enclosed literature lists give a survey of technical and experimental works at cyclotron. (author)

Association of Neuropeptide Y (NPY), Interleukin-1B (IL1B) Genetic Variants and Correlation of IL1B Transcript Levels with Vitiligo Susceptibility

Science.gov (United States)

Laddha, Naresh C.; Dwivedi, Mitesh; Mansuri, Mohmmad Shoab; Singh, Mala; Patel, Hetanshi H.; Agarwal, Nishtha; Shah, Anish M.; Begum, Rasheedunnisa

2014-01-01

Background Vitiligo is a depigmenting disorder resulting from loss of functional melanocytes in the skin. NPY plays an important role in induction of immune response by acting on a variety of immune cells. NPY synthesis and release is governed by IL1B. Moreover, genetic variability in IL1B is reported to be associated with elevated NPY levels. Objectives Aim of the present study was to explore NPY promoter −399T/C (rs16147) and exon2 +1128T/C (rs16139) polymorphisms as well as IL1B promoter −511C/T (rs16944) polymorphism and to correlate IL1B transcript levels with vitiligo. Methods PCR-RFLP method was used to genotype NPY -399T/C SNP in 454 patients and 1226 controls; +1128T/C SNP in 575 patients and 1279 controls and IL1B −511C/T SNP in 448 patients and 785 controls from Gujarat. IL1B transcript levels in blood were also assessed in 105 controls and 95 patients using real-time PCR. Results Genotype and allele frequencies for NPY −399T/C, +1128T/C and IL1B −511C/T SNPs differed significantly (pvitiligo by 2.3 fold (pvitiligo (p = 0.015), also in female patients than male patients (p = 0.026). Genotype-phenotype correlation showed moderate association of IL1B -511C/T polymorphism with higher IL1B transcript levels. Trend analysis revealed significant difference between patients and controls for IL1B transcript levels with respect to different genotypes. Conclusion Our results suggest that NPY −399T/C, +1128T/C and IL1B −511C/T polymorphisms are associated with vitiligo and IL1B −511C/T SNP influences its transcript levels leading to increased risk for vitiligo in Gujarat population. Up-regulation of IL1B transcript in patients advocates its possible role in autoimmune pathogenesis of vitiligo. PMID:25221996

Medical cyclotrons

International Nuclear Information System (INIS)

Wolf, A.P.

1976-01-01

Cyclotrons as tools for therapy and for the production of radionuclides for use in nuclear medicine have been extensively reviewed in the literature. The current world status with respect to cyclotrons used primarily for research, development and application in nuclear medicine is reviewed here in the context of geographical distribution and type of use, presently available commercial types, machine characteristics and trends. Aspects of design requirements from a user perspective such as machine, beam and target characteristics are covered. Some special problems concerning many factors which can lead to effective production of the desired radionuclide or product are considered in light of machine characteristics. Consideration is also given to future directions for accelerators in nuclear medicine

High-intensity cyclotrons for radioisotope production and accelerator driven systems

Energy Technology Data Exchange (ETDEWEB)

Jongen, Y.; Vandeplassche, D.; Kleeven, W.; Beeckman, W.; Zaremba, S.; Lannoye, G.; Stichelbaut, F

2002-04-22

IBA recently proposed a new method to extract high-intensity positive ion beams from a cyclotron based on the concept of auto-extraction. We review the design of a 14 MeV, multi-milliampere cyclotron using this new technology. IBA is also involved in the design of the accelerator system foreseen to drive the MYRRHA facility, a multipurpose neutron source developed jointly by SCK-CEN and IBA.

Application of superconductivity in cyclotron construction

International Nuclear Information System (INIS)

Blosser, H.G.

1982-01-01

This paper reviews major concepts and design features of the new class of cyclotrons which use superconducting coils to provide main magnet excitation. The discussion begins with a brief historical review tracing the evolution of these ''superconducting'' cyclotrons and the impact of this application of superconductivity in pushing back traditional cyclotron construction limits. This is followed by a review of the principal phenomena which come into play to set new limits on the operating regime, and the nature of these limits, some of which arise from orbit properties and some of which result from construction intricacies in the coil and in the rf system. Conclusions anticipate a future widely encompassing role in the application of superconductivity to cyclotron

Association of neuropeptide Y (NPY, interleukin-1B (IL1B genetic variants and correlation of IL1B transcript levels with vitiligo susceptibility.

Directory of Open Access Journals (Sweden)

Naresh C Laddha

Full Text Available BACKGROUND: Vitiligo is a depigmenting disorder resulting from loss of functional melanocytes in the skin. NPY plays an important role in induction of immune response by acting on a variety of immune cells. NPY synthesis and release is governed by IL1B. Moreover, genetic variability in IL1B is reported to be associated with elevated NPY levels. OBJECTIVES: Aim of the present study was to explore NPY promoter -399T/C (rs16147 and exon2 +1128T/C (rs16139 polymorphisms as well as IL1B promoter -511C/T (rs16944 polymorphism and to correlate IL1B transcript levels with vitiligo. METHODS: PCR-RFLP method was used to genotype NPY -399T/C SNP in 454 patients and 1226 controls; +1128T/C SNP in 575 patients and 1279 controls and IL1B -511C/T SNP in 448 patients and 785 controls from Gujarat. IL1B transcript levels in blood were also assessed in 105 controls and 95 patients using real-time PCR. RESULTS: Genotype and allele frequencies for NPY -399T/C, +1128T/C and IL1B -511C/T SNPs differed significantly (p<0.0001, p<0.0001; p = 0.0161, p = 0.0035 and p<0.0001, p<0.0001 between patients and controls. 'TC' haplotype containing minor alleles of NPY polymorphisms was significantly higher in patients and increased the risk of vitiligo by 2.3 fold (p<0.0001. Transcript levels of IL1B were significantly higher, in patients compared to controls (p = 0.0029, in patients with active than stable vitiligo (p = 0.015, also in female patients than male patients (p = 0.026. Genotype-phenotype correlation showed moderate association of IL1B -511C/T polymorphism with higher IL1B transcript levels. Trend analysis revealed significant difference between patients and controls for IL1B transcript levels with respect to different genotypes. CONCLUSION: Our results suggest that NPY -399T/C, +1128T/C and IL1B -511C/T polymorphisms are associated with vitiligo and IL1B -511C/T SNP influences its transcript levels leading to increased risk for vitiligo in

Radiation safety and quality control in the cyclotron laboratory

International Nuclear Information System (INIS)

Sharma, S.; Krause, G.; Ebadi, M.

2006-01-01

Radiation safety was determined to maintain quality control in the cyclotron laboratory. Based on the results of 438 runs in the Faraday cup (20 μA for 10 min), 20 runs on 18 O-water target (40 μA for 2 h) and 10 runs on 18 O-gas targets (30 μA for 45 min), we have established that occupationally exposed workers remain 10 ± 5 times below federal regulatory limits (FRLs) in the cyclotron vault, 30 ± 8 times below FRL in the radiochemistry laboratory and 200 ± 10 times below the FRL outside the cyclotron laboratory during beam operation. (The FRL for unrestricted area are <20 μSv in 1 h.) The non-occupationally exposed workers serving in offices in the vicinity of the cyclotron vault within 100 m distance remained 200 times below the FRL irrespective of beam being on or off, suggesting that routine beam operation of 40 μA for 2 h once a day during office hours is safe provided quality control and system performance measures as discussed in this report are strictly maintained. (authors)

New irradiation facilities at the Australian national medical cyclotron

International Nuclear Information System (INIS)

Parcell, S.K.; Arnott, D.W.; Conard, E.M.

1999-01-01

Two new irradiation facilities have been developed at the National Medical Cyclotron for radionuclide production. The first relocates PET irradiations from the cyclotron vault to a dedicated PET beam room, to improve accessibility and reduce radiation exposures associated with target maintenance. This new facility consists of a beam line to transport 16-30 MeV proton beams from the cyclotron to 1 of 8 PET targets mounted on a target rack. The target rack has increased the number of targets available for production and experimentation. The second is a completely independent solid target irradiation facility for SPECT. This facility consists of a beam line to transport 26-30 MeV proton beams from the cyclotron to a dedicated beam room containing one solid target station. A new pneumatic target transfer system was also developed to transport the solid target to and from the existing chemistry hot cells. The beam line and target components are operated under the control of a dedicated PLC with a PC based user interface. The development and some technical aspects of these new irradiation facilities are discussed here. (author)

Improving cancer treatment with cyclotron produced radionuclides

International Nuclear Information System (INIS)

Larson, S.M.; Finn, R.D.

1992-01-01

Our goal is to improve the scientific basis for tumor diagnosis, treatment and treatment follow-up based on the use of cyclotron produced radiotracers in oncology. The grant includes 3 interactive components: Radiochemistry/Cyclotron; Pharmacology; and Immunology. The radiochemistry group seeks to develop innovative cyclotron targetry, radiopharmaceuticals, and radiolabeled antibodies, which are then used to assess important unanswered questions in tumor pharmacology and immunology. Examples include selected positron emitting radionuclides, such as Iodine-124, and Ga-66; I-124, I-123, I-131 labeled iododeoxyuridine, C-11 colchicine, and antimetabolites, like C-11 methotrexate; and radiolabeled antibodies, 3F8, M195, A33, and MRK16 for application in the pharmacology and immunology projects. The pharmacology program studies tumor resistance to chemotherapy, particularly the phenomenon of multidrug resistance and the relationship between tumor uptake and retention and the tumor response for anti-metabolite drugs. The immunology program studies the physiology of antibody localization at the tissue level as the basis for novel approaches to improving tumor localization such as through the use of an artificial lymphatic system which mechanically reduces intratumoral pressures in tumors in vivo. Quantitative imaging approaches based on PET and SPECT in radioimmunotherapy are studied to give greater insight into the physiology of tumor localization and dosimetry

Passive cyclotron current drive for fusion plasmas

International Nuclear Information System (INIS)

Kernbichler, W.

1995-01-01

The creation of toroidal current using cyclotron radiation in a passive way is, together with the well known bootstrap current, an interesting method for stationary current drive in high-temperature fusion reactors. Here, instead of externally applied RF-waves, fish-scale like structures at the first wall help to create enough asymmetry in the self generated cyclotron radiation intensity to drive a current within the plasma. The problem of computing passive cyclotron current drive consists of actually two linked problems, which are the computation of the electron equilibrium under the presence of self-generated radiation, and the computation of the photon equilibrium in a bounded system with a distorted electron distribution. This system of integro-differential equations cannot be solved directly in an efficient way. Therefore a linearization procedure was developed to decouple both sets of equations, finally linked through a generalized local current drive efficiency. The problem of the exact accounting for the wall profile effects was reduced to the solution of a Fredholm-type integral equation of the 2 nd -kind. Based on all this an extensive computer code was developed to compute the passively driven current as well as radiation losses, radiation transport and overall efficiencies. The results therefrom give an interesting and very detailed insight into the problems related to passive cyclotron current drive

Medical isotope production experience at the V.G. Khlopin Radium Institute cyclotron

International Nuclear Information System (INIS)

Solin, L.M.

2000-01-01

Radium Institute cyclotron MGC-20 is used since 1990. There are four cyclotrons of such type in Russia and four abroad: in Finland, in Hungary, in North Korea and in Egypt. The Radium institute cyclotron was used in different fields, such as radioisotope production, nuclear physics, physics and engineering. For ten years some improvements of the Radium Institute cyclotron operation have been made. Those are: creation of the automatic control system based on IBM PC, development of a new power supply for the ion source, creation of the deflector electronic protection from discharges, change of the main elements of the cyclotron with high induced radioactivity. Moreover we investigated the possibility of the negative ions acceleration at the MGC-20 cyclotron without ion source exchange. The maximum value of the proton beam current reached was about 30 μA for 10 MeV H - beam energy. To extract the proton beam from the cyclotron after the stripping foil we made an additional output beam line. It was used for determination of the horizontal and vertical emittance. A special device was constructed and used for measurements of emittance. The latter amounted 30 π mm mrad for horizontal direction and 16 π mm mrad for vertical direction

National Medical Cyclotron

International Nuclear Information System (INIS)

Boyd, Rex.

1991-01-01

The National Medical Cyclotron, under construction at Sydney's Royal Prince Alfred Hospital(RPAH) is to be operated by the Australian Nuclear Science and Technology Organization in collaboration with the hospital. Its main purpose is to produce radioisotopes on commercial basis for distribution to hospitals through Australia as well as short-lived radioisotopes (2 minutes to 2 hours) for immediate application at RPAH in Positron Emission Tomography, to study the dynamics of human physiology and metabolism in organs, bones and soft tissues. A list of the principal cyclotron-produced radionuclides is provided. ills

Cyclotron Lines in Accreting Neutron Star Spectra

Science.gov (United States)

Wilms, Jörn; Schönherr, Gabriele; Schmid, Julia; Dauser, Thomas; Kreykenbohm, Ingo

2009-05-01

Cyclotron lines are formed through transitions of electrons between discrete Landau levels in the accretion columns of accreting neutron stars with strong (1012 G) magnetic fields. We summarize recent results on the formation of the spectral continuum of such systems, describe recent advances in the modeling of the lines based on a modification of the commonly used Monte Carlo approach, and discuss new results on the dependence of the measured cyclotron line energy from the luminosity of transient neutron star systems. Finally, we show that Simbol-X will be ideally suited to build and improve the observational database of accreting and strongly magnetized neutron stars.

Appetitive and consummatory ingestive behavior : Role of taste, dopamine and NPY

OpenAIRE

Sederholm, Fredrik

2001-01-01

The present thesis has examined the role of taste, dopamine and neuropeptide Y (NPY) in the regulation of the two phases of ingestive behavior: appetitive (approaching and handling of food) and consummatory ingestive behavior (chewing and swallowing). Behavioral studies were performed in male and female rats. THE ROLE OF TASTE: Background. A sweet stimulus loses its pleasantness to humans preloaded with glucose, but not if the subjects are food deprived. Thus, physiologi...

Ion sources for cyclotron applications

International Nuclear Information System (INIS)

Leung, K.N.; Bachman, D.A.; McDonald, D.S.; Young, A.T.

1992-07-01

The use of a multicusp plasma generator as an ion source has many advantages. The development of both positive and negative ion beams based on the multicusp source geometry is presented. It is shown that these sources can be operated at steady state or cw mode. As a result they are very suitable for cyclotron operations

Cyclotrons and positron emitting radiopharmaceuticals

International Nuclear Information System (INIS)

Wolf, A.P.; Fowler, J.S.

1984-01-01

The state of the art of Positron Emission Tomography (PET) technology as related to cyclotron use and radiopharmaceutical production is reviewed. The paper discusses available small cyclotrons, the positron emitters which can be produced and the yields possible, target design, and radiopharmaceutical development and application. 97 refs., 12 tabs

A new cyclotron for biomedical research

International Nuclear Information System (INIS)

Wolber, G.

1988-01-01

This paper presents the rationale for replacing the old AEG Compact Cyclotron (built in 1969/71) of the Institute for Radiology and Pathophysiology at the German Cancer Research Center by a 30 MeV H - /15 MeV D - cyclotron. A status report is followed by the scientific and technical reasoning as well as budgetary and organizational considerations. In the appendix we tried to explain the function of a cyclotron in a simple and comprehensive manner. (orig.) [de

Activity-dependent volume transmission by transgene NPY attenuates glutamate release and LTP in the subiculum

DEFF Research Database (Denmark)

Sørensen, Andreas T; Kanter-Schlifke, Irene; Lin, En-Ju D

2008-01-01

Neuropeptide Y (NPY) gene transduction of the brain using viral vectors in epileptogenic regions can effectively suppress seizures in animals, and is being considered as a promising alternative treatment strategy for epilepsy. Therefore, it is fundamental to understand the detailed mechanisms...

Cyclotrons and positron emitting radiopharmaceuticals

Energy Technology Data Exchange (ETDEWEB)

Wolf, A.P.; Fowler, J.S.

1984-01-01

The state of the art of Positron Emission Tomography (PET) technology as related to cyclotron use and radiopharmaceutical production is reviewed. The paper discusses available small cyclotrons, the positron emitters which can be produced and the yields possible, target design, and radiopharmaceutical development and application. 97 refs., 12 tabs. (ACR)

Influence of partially-stripped impurity ions on the cyclotron absorption of the fast magnetosonic wave in TFR plasmas

International Nuclear Information System (INIS)

1985-11-01

Injection of vanadium ions by the laser blow-off technique has permitted to modify at will the impurity content in TFR plasmas prior to ion-cyclotron resonance (ICR) heating experiments in the mode conversion regime. The initial rate of increase of the central deuteron temperature has thus been enhanced. By solving the wave propagation equation in the WKB approximation, it has been possible to account for the enhanced dTsub(D)(O)/dt value by wave energy deposition on resonating V 21+ ions, provided a fraction (of the order of 1O%) of these ions has been accelerated to the tens of keV range. Previous experimental ICR heating results, in conditions such that the proton cyclotron layer is outside the limiter radius, can be explained by similar resonance processes on intrinsic metal impurity ions

Optimization of the FAST ICRF antenna using TOPICA code

International Nuclear Information System (INIS)

Sorba, M.; Milanesio, D.; Maggiora, R.; Tuccillo, A.

2010-01-01

Ion Cyclotron Resonance Heating is one of the most important auxiliary heating systems in most plasma confinement experiments. Because of this, the need for very accurate design of ion cyclotron (IC) launchers has dramatically grown in recent years. Furthermore, a reliable simulation tool is a crucial request in the successful design of these antennas, since full testing is impossible outside experiments. One of the most advanced and validated simulation codes is TOPICA, which offers the possibility to handle the geometrical level of detail of a real antenna in front of an accurately described plasma scenario. Adopting this essential tool made possible to reach a refined design of ion cyclotron radio frequency antenna for the FAST (Fusion Advanced Studies Torus) experiment . Starting from a streamlined antenna model and then following well-defined refinement procedures, an optimized launcher design in terms of power delivered to plasma has been finally achieved. The computer-assisted geometry refinements allowed an increase in the performances of the antenna and notably in power handling: the extent of the gained improvements were not experienced in the past, essentially due to the absence of predictive tools capable of analyzing the detailed effects of antenna geometry in plasma facing conditions. Thus, with the help of TOPICA code, it has been possible to comply with the FAST experiment requirements in terms of vacuum chamber constraints and power delivered to plasma. Once an antenna geometry was optimized with a reference plasma profile, the analysis of the performances of the launcher has been extended with respect to two plasma scenarios. Exploiting all TOPICA features, it has been possible to predict the behavior of the launcher in real operating conditions, for instance varying the position of the separatrix surface. In order to fulfil the analysis of the FAST IC antenna, the study of the RF potentials, which depend on the parallel electric field computation

Cyclotron method for heavy ion acceleration

International Nuclear Information System (INIS)

Gikal, B.N.; Gul'bekyan, G.G.; Kutner, V.B.; Oganesyan, R.Ts.

1984-01-01

Studies on heavy ion beams in a wide range of masses (up to uranium) and energies disclose essential potential opportunities for solution of both fundamental scientific and significant economical problems. A cyclotron method for heavy ion acceleration is considered. Development of low and medium energy heavy ion accelerators is revealed. The design of a complex comprising two isochronous cyclotrons which is planned to be constrdcted 1n the JINR is described. The cyclotron complex includes the U-400 and the U-400 M cyclotrons and it is intended for acceleration of both 35-20 MeV/nucleon superheavy ions such as Xe-U and 120 MeV/nucleon light ions. Certain systems of the accelerators are described. Prospects of the U-400 and the U-400 M development are displayed

Cyclotron based nuclear science: Progress report, April 1, 1986-March 31, 1987

International Nuclear Information System (INIS)

1987-08-01

This report contains descriptions of research programs at the Institute, progress on construction of the K500 cyclotron, and descriptions of new experimental devices being built to take advantage of new beams that will be available. Several milestones were reached in construction of the new cyclotron during the period. In early summer, 1986, the magnet was completed with all trim coils and shimming iron in place. During July and August, the final field maps were made, which will be used for calculations of run parameters. In the spring, one rf amplifier was completed and tested over the full frequency and power range. Also in the spring, the computer control system successfully operated positioning controls and trim coil power supplies. Final assembly of the rf system including the dees, resonators and other 2 rf amplifiers is now underway. Initial attempts at getting beam are expected in September. The design of the ECR source was completed in the fall. A beam line configuration has been designed for the K500 cyclotron which will result initially in 3 lines, with a fourth to be added in 1988. With the eminent completion of the K500, there has been considerable instrumentation development. A 4π neutron calorimeter is under construction for heavy ion reaction studies, construction is beginning on a proton spectrometer for studies of Gamow-Teller matrix elements with the (d, 2 He) reaction, and several detector systems are being developed. During the year, the 88 inch cyclotron operated 4845 hours for research and beam development. Research programs in nuclear science scheduled 57% of the time. Atomic physics programs used 19% of the time, and a program in trace analysis scheduled 6%. An industrial testing laboratory used 18 hours. The remainder of the time was used for beam development, primarily for increasing the energy and/or intensity of heavy ion beams

Acceleration of the Fast Solar Wind through Minor Ions

Science.gov (United States)

Li, X.

2004-01-01

It is assumed that the magnetic flux tubes are strongly concentrated at the boundaries of the supergranule convection cells. A power law spectrum of high frequency Alfvén waves with a spectral index -1 originating from the sun is assumed to supply all the energy needed to energize the plasma flowing in such magnetic flux tubes. At the high frequency end, the waves are eroded by ions due to ion cyclotron resonance. The magnetic flux concentration is essential since it allows a sufficiently strong energy flux to be carried by high frequency ion cyclotron waves and these waves can be readily released at the coronal base by cyclotron resonance. The main results are: 1. By primarily heating alpha particles only, it is possible to produce a steep transition region, a hot corona and a fast solar wind. Coulomb coupling plays a key role in transferring the thermal energy of alpha particles to protons and electrons at the corona base. The electron thermal conduction then does the remaining job to create a sharp transition region. 2. Plasma species may already partially lose thermal equilibrium in the transition region, minor ions may already be faster than protons at the very bottom of the corona. 3. The model predicts high temperature alpha particles (T 2 × 107 K) and low proton temperatures (Tp solar radii, suggests that hydrogen Lyman lines observed by UVCS above coronal holes may be primarily broadened by Alfvén waves in this range.

Electron cyclotron waves transmission: new approach for the characterization of electron distribution functions in Tokamak hot plasmas

International Nuclear Information System (INIS)

Michelot, Y.

1995-10-01

Fast electrons are one of the basic ingredients of plasma operations in many existing thermonuclear fusion research devices. However, the understanding of fast electrons dynamics during creation and sustainment of the superthermal electrons tail is far for being satisfactory. For this reason, the Electron Cyclotron Transmission (ECT) diagnostic was implemented on Tore Supra tokamak. It consists on a microwave transmission system installed on a vertical chord crossing the plasma center and working in the frequency range 77-109 GHz. Variations of the wave amplitude during the propagation across the plasma may be due to refraction and resonant absorption. For the ECT, the most common manifestation of refraction is a reduction of the received power density with respect to the signal detected in vacuum, due to the spreading and deflection of the wave beam. Wave absorption is observed in the vicinity of the electron cyclotron harmonics and may be due both to thermal plasma and to superthermal electron tails. It has a characteristic frequency dependence due to the relativistic mass variation in the wave-electron resonance condition. This thesis presents the first measurements of: the extraordinary mode optical depth at the third harmonics, the electron temperature from the width of a cyclotron absorption line and the relaxation times of the electron distribution during lower hybrid current drive from the ordinary mode spectral superthermal absorption line at the first harmonic. (J.S.). 175 refs., 110 figs., 9 tabs., 3 annexes

Cost benefit analysis of the radiological shielding of medical cyclotrons using a genetic algorithm

International Nuclear Information System (INIS)

Mukherjee, Bhaskar

2001-01-01

Adequate radiation shielding is vital to the safe operation of modern commercial medical cyclotrons producing large yields of short-lived radioisotopes. The radiological shielding constitutes a significant capital investment for any new cyclotron-based radioisotope production facility; hence, the shielding design requires an accurate cost-benefit analysis often based on a complex multi-variant optimization technique. This paper demonstrates the application of a Genetic Algorithm (GA) for the optimum design of the high yield target cave of a Medical Cyclotron radioisotope production facility based in Sydney, Australia. The GA is a novel optimization technique that mimics the Darwinian Evolution paradigm and is ideally suited to search for global optima in a large multi-dimensional solution space

Commercial cyclotrons. Part I: Commercial cyclotrons in the energy range 10 30 MeV for isotope production

Science.gov (United States)

Papash, A. I.; Alenitsky, Yu. G.

2008-07-01

A survey of commercial cyclotrons for production of medical and industrial isotopes is presented. Compact isochronous cyclotrons which accelerate negative hydrogen ions in the energy range 10 30 MeV have been widely used over the last 25 years for production of medical isotopes and other applications. Different cyclotron models for the energy range 10 12 MeV with moderate beam intensity are used for production of 11C, 13N, 15O, and 18F isotopes widely applied in positron emission tomography. Commercial cyclotrons with high beam intensity are available on the market for production of most medical and industrial isotopes. In this work, the physical and technical parameters of different models are compared. Possibilities of improving performance and increasing intensity of H- beams up to 2 3 mA are discussed.

Solid targetry for compact cyclotrons

International Nuclear Information System (INIS)

Comor, J.

2004-01-01

In this presentation authors present experimental results of solid targetry for compact cyclotrons. It is concluded: Solid targetry is not restricted to large accelerator centers anymore; Small and medium scale radioisotope production is feasible with compact cyclotrons; The availability of versatile solid target systems is expected to boost the radiochemistry of 'exotic' positron emitters

Fast wave current drive in neutral beam heated plasmas on DIII-D

International Nuclear Information System (INIS)

Petty, C.C.; Forest, C.B.; Pinsker, R.I.

1997-04-01

The physics of non-inductive current drive and current profile control using the fast magnetosonic wave has been demonstrated on the DIII-D tokamak. In non-sawtoothing discharges formed by neutral beam injection (NBI), the radial profile of the fast wave current drive (FWCD) was determined by the response of the loop voltage profile to co, counter, and symmetric antenna phasings, and was found to be in good agreement with theoretical models. The application of counter FWCD increased the magnetic shear reversal of the plasma and delayed the onset of sawteeth, compared to co FWCD. The partial absorption of fast waves by energetic beam ions at high harmonics of the ion cyclotron frequency was also evident from a build up of fast particle pressure near the magnetic axis and a correlated increase in the neutron rate. The anomalous fast particle pressure and neutron rate increased with increasing NBI power and peaked when a harmonic of the deuterium cyclotron frequency passed through the center of the plasma. The experimental FWCD efficiency was highest at 2 T where the interaction between the fast waves and the beam ions was weakest; as the magnetic field strength was lowered, the FWCD efficiency decreased to approximately half of the maximum theoretical value

arXiv Cyclotrons: Magnetic Design and Beam Dynamics

CERN Document Server

Zaremba, Simon

Classical, isochronous, and synchro-cyclotrons are introduced. Transverse and longitudinal beam dynamics in these accelerators are covered. The problem of vertical focusing and iscochronism in compact isochronous cyclotrons is treated in some detail. Different methods for isochronization of the cyclotron magnetic field are discussed. The limits of the classical cyclotron are explained. Typical features of the synchro-cyclotron, such as the beam capture problem, stable phase motion, and the extraction problem are discussed. The main design goals for beam injection are explained and special problems related to a central region with an internal ion source are considered. The principle of a Penning ion gauge source is addressed. The issue of vertical focusing in the cyclotron centre is briefly discussed. Several examples of numerical simulations are given. Different methods of (axial) injection are briefly outlined. Different solutions for beam extraction are described. These include the internal target, extracti...

Recent development and progress of IBA cyclotrons

Energy Technology Data Exchange (ETDEWEB)

Kleeven, W., E-mail: Willem.Kleeven@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Abs, M., E-mail: Michel.Abs@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Delvaux, J.L., E-mail: Jean-Luc.Delvaux@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Forton, E., E-mail: Eric.Forton@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Jongen, Y., E-mail: Yves.Jongen@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Medeiros Romao, L., E-mail: Luis.MedeirosRomao@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Nactergal, B., E-mail: Benoit.Nactergal@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Nuttens, V., E-mail: Vincent.Nuttens@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Servais, T., E-mail: Thomas.Servais@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Vanderlinden, T., E-mail: Thierry.Vanderlinden@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Zaremba, S., E-mail: Simon.Zaremba@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium)

2011-12-15

Several cyclotron development projects were recently realized by Ion Beam Applications S.A. (IBA). This contribution presents three of them: (i) the intensity enhancement of the Cyclone 30 cyclotron, a machine mainly used for the production of SPECT isotopes. This project is related with the increased demand for {sup 201}Tl because of the shortage of Mo/Tc generators from nuclear reactors, (ii) development of a new versatile multiple-particle K = 30 isotope-production cyclotron (the Cyclone 30XP) being able to accelerate H{sup -}, D{sup -} and also {alpha}-particles. The {alpha}-beam of this cyclotron will allow the production of new therapeutic isotopes (e.g. {sup 211}At) and (iii) commissioning of the Cyclone 70 cyclotron installed for Arronax in France. This machine is similar to the C30XP but provides higher energy (K = 70) and allows research on new types of medical isotopes.

Synchro-cyclotron

CERN Multimedia

CERN PhotoLab

1972-01-01

The electromagnetic coil which forms the first section of the proton extraction channel in the improved synchro-cyclotron. The photograph shows the positioning gear and the current septum. An extraction efficiency above 50% is expected.

SPES: A new cyclotron-based facility for research and applications with high-intensity beams

Science.gov (United States)

Maggiore, M.; Campo, D.; Antonini, P.; Lombardi, A.; Manzolaro, M.; Andrighetto, A.; Monetti, A.; Scarpa, D.; Esposito, J.; Silvestrin, L.

2017-06-01

In 2016, Laboratori Nazionali di Legnaro (Italy) started the commissioning of a new accelerator facility based on a high-power cyclotron able to deliver proton beams up to 70 MeV of energy and 700 μA current. Such a machine is the core of the Selective Production of Exotic Species (SPES) project whose main goal is to provide exotics beam for nuclear and astrophysics research and to deliver high-intensity proton beams for medical applications and neutrons generator.

Human Lymphatic Mesenteric Vessels: Morphology and Possible Function of Aminergic and NPY-ergic Nerve Fibers.

Science.gov (United States)

D'Andrea, Vito; Panarese, Alessandra; Taurone, Samanta; Coppola, Luigi; Cavallotti, Carlo; Artico, Marco

2015-09-01

The lymphatic vessels have been studied in different organs from a morphological to a clinical point of view. Nevertheless, the knowledge of the catecholaminergic control of the lymphatic circulation is still incomplete. The aim of this work is to study the presence and distribution of the catecholaminergic and NPY-ergic nerve fibers in the whole wall of the human mesenteric lymphatic vessels in order to obtain knowledge about their morphology and functional significance. The following experimental procedures were performed: 1) drawing of tissue containing lymphatic vessels; 2) cutting of tissue; 3) staining of tissue; 4) staining of nerve fibers; 5) histofluorescence microscopy for the staining of catecholaminergic nerve fibers; 6) staining of neuropeptide Y like-immune reactivity; 7) biochemical assay of proteins; 8) measurement of noradrenaline; 9) quantitative analysis of images; 10) statistical analysis of data. Numerous nerve fibers run in the wall of lymphatic vessels. Many of them are catecholaminergic in nature. Some nerve fibers are NPY-positive. The biochemical results on noradrenaline amounts are in agreement with morphological results on catecholaminergic nerve fibers. Moreover, the morphometric results, obtained by the quantitative analysis of images and the subsequent statistical analysis of data, confirm all our morphological and biochemical data. The knowledge of the physiological or pathological mechanism regulating the functions of the lymphatic system is incomplete. Nevertheless the catecholaminergic nerve fibers of the human mesenteric lymphatic vessels come from the adrenergic periarterial plexuses of the mesenterial arterial bed. NPY-ergic nerve fibers may modulate the microcirculatory mesenterial bed in different pathological conditions.

Characterization of electron cyclotron resonance hydrogen plasmas

International Nuclear Information System (INIS)

Outten, C.A.

1990-01-01

Electron cyclotron resonance (ECR) plasmas yield low energy and high ion density plasmas. The characteristics downstream of an ECR hydrogen plasma were investigated as a function of microwave power and magnetic field. A fast-injection Langmuir probe and a carbon resistance probe were used to determine plasma potential (V p ), electron density (N e ), electron temperature (T e ), ion energy (T i ), and ion fluence. Langmuir probe results showed that at 17 cm downstream from the ECR chamber the plasma characteristics are approximately constant across the center 7 cm of the plasma for 50 Watts of absorbed power. These results gave V p = 30 ± 5 eV, N e = 1 x 10 8 cm -3 , and T e = 10--13 eV. In good agreement with the Langmuir probe results, carbon resistance probes have shown that T i ≤ 50 eV. Also, based on hydrogen chemical sputtering of carbon, the hydrogen (ion and energetic neutrals) fluence rate was determined to be 1 x 10 16 /cm 2 -sec. at a pressure of 1 x 10 -4 Torr and for 50 Watts of absorbed power. 19 refs

Compact superconducting cyclotron C400 for hadron therapy

Energy Technology Data Exchange (ETDEWEB)

Jongen, Y.; Abs, M.; Blondin, A.; Kleeven, W.; Zaremba, S.; Vandeplassche, D. [IBA, Chemin du Cyclotron 3, B-1348 Louvain-la-Neuve (Belgium); Aleksandrov, V.; Gursky, S.; Karamyshev, O. [JINR, Joliot-Curie 6, 141980 Dubna, Moscow region (Russian Federation); Karamysheva, G., E-mail: gkaram@nu.jinr.r [JINR, Joliot-Curie 6, 141980 Dubna, Moscow region (Russian Federation); Kazarinov, N.; Kostromin, S.; Morozov, N.; Samsonov, E.; Shirkov, G.; Shevtsov, V.; Syresin, E.; Tuzikov, A. [JINR, Joliot-Curie 6, 141980 Dubna, Moscow region (Russian Federation)

2010-12-01

The compact superconducting isochronous cyclotron C400 has been designed by the IBA-JINR collaboration. It will be the first cyclotron in the world capable of delivering protons, carbon and helium ions for cancer treatment. The cyclotron construction is started this year within the framework of the Archade project (Caen, France). {sup 12}C{sup 6+} and {sup 4}He{sup 2+} ions will be accelerated to 400 MeV/uu energy and extracted by the electrostatic deflector, H{sub 2}{sup +} ions will be accelerated to the energy of 265 MeV/uu and extracted by stripping. The magnet yoke has a diameter of 6.6 m, the total weight of the magnet is about 700 t. The designed magnetic field corresponds to 4.5 T in the hills and 2.45 T in the valleys. Superconducting coils will be enclosed in a cryostat; all other parts of the cyclotron will be warm. Three external ion sources will be mounted on the switching magnet on the injection line located below the cyclotron. The main parameters of the cyclotron, its design, the current status of the development work on the cyclotron systems are presented.

The NSCL cyclotron gas stopper – Entering commissioning

Energy Technology Data Exchange (ETDEWEB)

Schwarz, S. [National Superconducting Cyclotron Laboratory, East Lansing, MI (United States); Bollen, G. [Department of Physics and Astronomy, Michigan State University, East Lansing, MI (United States); Facility for Rare Isotope Beams, East Lansing, MI (United States); Chouhan, S. [Facility for Rare Isotope Beams, East Lansing, MI (United States); Das, J.J. [National Superconducting Cyclotron Laboratory, East Lansing, MI (United States); Green, M. [Facility for Rare Isotope Beams, East Lansing, MI (United States); Magsig, C. [National Superconducting Cyclotron Laboratory, East Lansing, MI (United States); Morrissey, D.J. [National Superconducting Cyclotron Laboratory, East Lansing, MI (United States); Department of Chemistry, Michigan State University, East Lansing, MI 48824 (United States); Ottarson, J.; Sumithrarachchi, C. [National Superconducting Cyclotron Laboratory, East Lansing, MI (United States); Villari, A.C.C.; Zeller, A. [Facility for Rare Isotope Beams, East Lansing, MI (United States)

2016-06-01

Linear gas stopping cells have been used successfully at NSCL to slow down ions produced by projectile fragmentation from the 100 MeV/u to the keV energy range. These ‘stopped beams’ have first been used for low-energy high precision experiments and more recently for NSCLs re-accelerator ReA. A gas-filled reverse cyclotron is currently under construction by the NSCL to complement the existing stopping cells: Due to its extended stopping length, efficient stopping and fast extraction is expected even for light and medium-mass ions, which are difficult to thermalize in linear gas cells. The device is based on a 2.6 T maximum-field cyclotron-type magnet to confine the injected beam while it is slowed down in ≈100 mbar of LN{sub 2}-temperature helium gas. Once thermalized, the beam will be transported to the center of the device by a traveling-wave RF-carpet system, extracted along the symmetry axis with an ion conveyor and miniature RF-carpets, and accelerated to a few tens of keV of energy for delivery to the users. The superconducting magnet has been constructed on a 60 kV platform and energized to its nominal field strength. The magnet’s two cryostats use 3 cryo-refrigerators each and liquid-nitrogen cooled thermal shields to cool the coil pair to superconductivity. This concept, chosen not to have to rely on external liquid helium, has been working well. Measurements of axial and radial field profiles confirm the field calculations. The individual RF-ion guiding components for low-energy ion transport through the device have been tested successfully. The beam stopping chamber with its 0.9 m-diameter RF carpet system and the ion extraction system are being prepared for installation inside the magnet for low-energy ion transport tests.

A full wave code for ion cyclotron waves in toroidal plasmas

International Nuclear Information System (INIS)

Brambilla, M.

1996-02-01

The code TORIC solves the finite Larmor radius wave equations in the ion cyclotron frequency range in arbitrary axisymmetric toroidal geometry. The model used describes the compressional and torsional Alfven waves (or, depending on the parallel phase velocity, the kinetic counterpart of the latter), and ion Bernstein waves excited by mode conversion near the first ion cyclotron harmonic. In the ion response the broadening of the absorption regions due to the finite width of the cyclotron resonance of individual ions in toroidal geometry is taken into account. The parallel component of the wave electric field is evaluated on the same footing as the transverse ones; the response of the electrons includes Landau damping, Transit Time damping and the mixed term. The numerical approach uses a spectral representation of the solution in the poloidal angle θ, and cubic finite elements in the radial variable ψ. Great flexibility is provided in the way ion Bernstein waves excited by mode conversion are damped when their wavelength becomes comparable with the ion Larmor radius, in the regularization of Alfven resonances, and in the treatment of the outer plasma layers. As an option, we have also implemented the Order Reduction Algorithm, which provides a particularly fast, yet accurate evaluation of the power deposition profiles in toroidal geometry. Thee present report describes the model and its numerical implementation, and provides the information needed to use the code. A few examples illustrating applications of TORIC are also included. (orig.)

Design study of electrostatic inflector in compact cyclotron injection system

International Nuclear Information System (INIS)

Zhang Tianjue; Fan Mingwu

1996-01-01

The beam dynamics behaviour in electrostatic inflector is investigated for a vertical type injection system to a compact cyclotron. The computer aided design and matching of the inflector are based on the simulation of computed beam orbit. Modeling and simulation are done on PC-486 to form a software package. The software package can be used to develop a new type cyclotron design combining with the software package CYCCAE developed by China Institute of Atomic Energy three years ago

Electron-cyclotron-resonance ion sources (review)

International Nuclear Information System (INIS)

Golovanivskii, K.S.; Dougar-Jabon, V.D.

1992-01-01

The physical principles are described and a brief survey of the present state is given of ion sources based on electron-cyclotron heating of plasma in a mirror trap. The characteristics of ECR sources of positive and negative ions used chiefly in accelerator technology are presented. 20 refs., 10 figs., 3 tabs

Activations of c-fos/c-jun signaling are involved in the modulation of hypothalamic superoxide dismutase (SOD) and neuropeptide Y (NPY) gene expression in amphetamine-mediated appetite suppression

International Nuclear Information System (INIS)

Hsieh, Y.-S.; Yang, S.-F.; Chiou, H.-L.; Kuo, D.-Y.

2006-01-01

Amphetamine (AMPH) is known as an anorectic agent. The mechanism underlying the anorectic action of AMPH has been attributed to its inhibitory action on hypothalamic neuropeptide Y (NPY), an appetite stimulant in the brain. This study was aimed to examine the molecular mechanisms behind the anorectic effect of AMPH. Results showed that AMPH treatment decreased food intake, which was correlated with changes of NPY mRNA level, but increased c-fos, c-jun and superoxide dismutase (SOD) mRNA levels in hypothalamus. To determine if c-fos or c-jun was involved in the anorectic response of AMPH, infusions of antisense oligonucleotide into the brain were performed at 1 h before daily AMPH treatment in freely moving rats, and the results showed that c-fos or c-jun knockdown could block this anorectic response and restore NPY mRNA level. Moreover, c-fos or c-jun knockdown could partially block SOD mRNA level that might involve in the modulation of NPY gene expression. It was suggested that c-fos/c-jun signaling might involve in the central regulation of AMPH-mediated feeding suppression via the modulation of NPY gene expression

Cyclotron-based nuclear science. Progress report, April 1, 1979-March 31, 1980

Energy Technology Data Exchange (ETDEWEB)

1980-06-01

Research at the cyclotron institute is summarized. These major areas are covered: nuclear structure; nuclear reactions and scattering; polarization studies; interdisciplinary nuclear science; instrumentation and systems development; and publications. (GHT)

Glut2-dependent glucose-sensing controls thermoregulation by enhancing the leptin sensitivity of NPY and POMC neurons.

Science.gov (United States)

Mounien, Lourdes; Marty, Nell; Tarussio, David; Metref, Salima; Genoux, David; Preitner, Frédéric; Foretz, Marc; Thorens, Bernard

2010-06-01

The physiological contribution of glucose in thermoregulation is not completely established nor whether this control may involve a regulation of the melanocortin pathway. Here, we assessed thermoregulation and leptin sensitivity of hypothalamic arcuate neurons in mice with inactivation of glucose transporter type 2 (Glut2)-dependent glucose sensing. Mice with inactivation of Glut2-dependent glucose sensors are cold intolerant and show increased susceptibility to food deprivation-induced torpor and abnormal hypothermic response to intracerebroventricular administration of 2-deoxy-d-glucose compared to control mice. This is associated with a defect in regulated expression of brown adipose tissue uncoupling protein I and iodothyronine deiodinase II and with a decreased leptin sensitivity of neuropeptide Y (NPY) and proopiomelanocortin (POMC) neurons, as observed during the unfed-to-refed transition or following i.p. leptin injection. Sites of central Glut-2 expression were identified by a genetic tagging approach and revealed that glucose-sensitive neurons were present in the lateral hypothalamus, the dorsal vagal complex, and the basal medulla but not in the arcuate nucleus. NPY and POMC neurons were, however, connected to nerve terminals from Glut2-expressing neurons. Thus, our data suggest that glucose controls thermoregulation and the leptin sensitivity of NPY and POMC neurons through activation of Glut2-dependent glucose-sensing neurons located outside of the arcuate nucleus.

H-superconducting cyclotron for PET isotope production

International Nuclear Information System (INIS)

Smirnov, V.L.; Vorozhtsov, S.B.; Vincent, J.

2014-01-01

The scientific design of a 14-MeV H - compact superconducting cyclotron for producing of the 18 F and 13 N isotopes has been developed. Main requirements to the facility as a medical accelerator are met in the design. In particular, the main requirement for the cyclotron was the smallest possible size due to the superconducting magnet. The calculations show that the proposed cyclotron allows extracted beam intensity over 500 μA. To increase system reliability and production rates, an external H - ion source is applied. The choice of the cyclotron concept, design of the structure elements, calculation of the electromagnetic fields and beam dynamics from the ion source to the extraction system were performed.

Fast-ion Dα measurements of the fast-ion distribution (invited)

International Nuclear Information System (INIS)

Heidbrink, W. W.

2010-01-01

The fast-ion Dα (FIDA) diagnostic is an application of charge-exchange recombination spectroscopy. Fast ions that neutralize in an injected neutral beam emit Balmer-α light with a large Doppler shift. The spectral shift is exploited to distinguish the FIDA emission from other bright sources of Dα light. Background subtraction is the main technical challenge. A spectroscopic diagnostic typically achieves temporal, energy, and transverse spatial resolution of ∼1 ms, ∼10 keV, and ∼2 cm, respectively. Installations that use narrow-band filters achieve high spatial and temporal resolution at the expense of spectral information. For high temporal resolution, the bandpass-filtered light goes directly to a photomultiplier, allowing detection of ∼50 kHz oscillations in FIDA signal. For two-dimensional spatial profiles, the bandpass-filtered light goes to a charge-coupled device camera; detailed images of fast-ion redistribution at instabilities are obtained. Qualitative and quantitative models relate the measured FIDA signals to the fast-ion distribution function. The first quantitative comparisons between theory and experiment found excellent agreement in beam-heated magnetohydrodynamics (MHD)-quiescent plasmas. FIDA diagnostics are now in operation at magnetic-fusion facilities worldwide. They are used to study fast-ion acceleration by ion cyclotron heating, to detect fast-ion transport by MHD modes and microturbulence, and to study fast-ion driven instabilities.

Status report on cyclotron operation

International Nuclear Information System (INIS)

Kovacs, P.; Szuecs, I.; Ander, I.; Lakatos, T.; Fenyvesi, A.; Ditroi, F.; Takacs, S.; Tarkanyi, F.

2004-01-01

The operation of the cyclotron in 2003 was again concentrated to 9 months; January, July and August were reserved for maintenance, renewal works and holidays. The overall working time of the accelerator was 4051 hours. The cyclotron was available for users for 3682 hours. In order to improve the circumstances of the irradiations renewal and improvements were done. (N.T.)

Spiral inflector and central region study for three cyclotrons at CIAE

International Nuclear Information System (INIS)

Zhang Tianjue; Yao Hongjuan; Guan Fengping; Chu Chengjie; Lu Yinlong; Jia Xianlu; Zhong Junqing; Yang Jianjun; Xing Jiansheng; Lin Yuzheng

2007-01-01

The beam dynamics behaviour in the compact cyclotron central region is investigated. The design study for central region, including the spiral inflector, Dee tip, shield and posts, for three cyclotrons at CIAE will be described in this paper. The code development by CIAE and the UNIX based codes developed by TRIUMF were implemented on WINDOWS/PC by CIAE for the spiral inflector and central region design will be given too

An ion source upgrade for an axial injection based commercial cyclotron

International Nuclear Information System (INIS)

Dehnel, M.P.; Stewart, T.; Roeder, M.; Le Du, K.

2005-01-01

The TRIUMF H - volume-cusp ion source technology licensed by Dehnel Consulting Ltd ranges in output current from 1 to 15 mA with beam energies in the 22-30 keV range. For those Cyclone 30 cyclotrons installed with an early 1980's style Lawrence Berkeley Lab (LBL) volume-cusp ion source, an upgrade to a 5 mA TRIUMF H - volume-cusp ion source would pay dividends in terms of longer filament, filament post and ion source lens lifetime, as well as less eroded material build-up in the source. In addition, the 5 mA ion source would approximately double the beam current available to inject into the cyclotron while reducing the emittance by about a factor of four. The new system has the potential to significantly boost radioisotope production at Cyclone 30 facilities utilizing the older style LBL ion source

Boron neutron capture therapy (BNCT) using fast neutrons: Effects in two human tumor cell lines

International Nuclear Information System (INIS)

Sauerwein, W.; Ziegler, W.; Szypniewski, H.; Streffer, C.

1990-01-01

The results demonstrate that the effect of fast neutrons on cell survival in cell culture can be enhanced by boron neutron capture reaction. Even with lower enhancement ratios, the concept of NCT assisted fast neutron therapy may successfully be applied for tumor treatment with the Essen cyclotron. (orig.)

A national medical cyclotron facility: report to the Minister of Health by the Medical Cyclotron Committee

International Nuclear Information System (INIS)

1985-01-01

Research and training in nuclear medicine in Australia are both limited by the lack of a medical cyclotron facility. The Committee recommends the establishment of a national medical cyclotron to provide a supply of short-lived radioisotopes for research in relevant fields of medicine, and for diagnostic use in nuclear medicine

Distribution of peptidergic populations in the human dentate gyrus (somatostatin [SOM-28, SOM-12] and neuropeptide Y [NPY]) during postnatal development.

Science.gov (United States)

Cebada-Sánchez, S; Insausti, R; González-Fuentes, J; Arroyo-Jiménez, M M; Rivas-Infante, E; Lagartos, M J; Martínez-Ruiz, J; Lozano, G; Marcos, P

2014-10-01

The postnatal development of the human hippocampal formation establishes the time and place at which we start autobiographical memories. However, data concerning the maturation of the neurochemical phenotypes characteristic of interneurons in the human hippocampus are scarce. We have studied the perinatal and postnatal changes of the dentate gyrus (DG) interneuron populations at three rostrocaudal levels. Immunohistochemically identified neurons and fibers for somatostatin (SOM-12 and SOM-28) and neuropeptide Y (NPY) and the co-localization of SOM-28 and NPY were analyzed. In total, 13 cases were investigated from late pregnancy (1 case), perinatal period (6 cases), first year (1 case), early infancy (3 cases), and late infancy (2 cases). Overall, the pattern of distribution of these peptides in the DG was similar to that of the adult. The distribution of cells was charted, and the cell density (number of positive cells/mm(2)) was calculated. The highest density corresponded to the polymorphic cell layer and was higher at pre- and perinatal periods. At increasing ages, neuron density modifications revealed a decrease from 5 postnatal months onward. In contrast, by late infancy, two immunoreactive bands for SOM-28 and NPY in the molecular layer were much better defined. Double-immunohistochemistry showed that NPY-positive neurons co-localized with SOM-28, whereas some fibers contained only one or other of the neuropeptides. Thus, this peptidergic population, presumably inhibitory, probably has a role in DG maturation and its subsequent functional activity in memory processing.

Development of cyclotron solid targetry

International Nuclear Information System (INIS)

D'Souza, J.; Deans, T.; Cryer, D.; Price, R.

2004-01-01

Full text: Western Australia's first medical cyclotron was recently installed in the Department of Medical Technology and Physics at Sir Charles Gairdner Hospital. The cyclotron is routinely used for 18 F production using a liquid target, and now research is being undertaken into solid target bombardment for production of novel isotopes such as 124 I, 64 Cu and 96 Tc. The IBA Cyclone 18/9 has a maximum proton beam energy of 18MeV and maximum beam current of 80μA. A proton beam is generated by the acceleration of H- ions in the evacuated cyclotron (10 -6 bar) which are then stripped of 2 electrons just prior to exiting a target port. Each port has two strippers which are made of 10μm thick carbon with dimensions 12mmxl3mm. Due to their thinness, the strippers are easily ruptured. The Cyclone 18/9 has 8 target ports. In order to fit a target onto the cyclotron when the cyclotron is already evacuated the target is first evacuated to 10 -3 bar by a roughing pump before an isolation valve at the port is opened. This stops any damage that may occur by the flow of air from the target reservoir to the cyclotron eg to the strippers. The first step in the project to develop solid targetry is to build a beam line in order to measure the beam profile. If successful, this design will be improved in order to have a beam line and target holder that are suitable for use in solid target bombardment. A 40cm beam line with an internal diameter of 3.6cm was built to fit onto the IBA Cyclone 18/9. The beam line, made out of aluminium, incorporates a step 5cm from the end at which a target material can be fitted. A cover fits onto the beam line, behind the target in order to maintain vacuum. The cover is held in place by the vacuum within the beam line. At the end of bombardment, the beam line can be isolated from the vacuum of the target and normal air pressure restored. In doing so the cover plate falls open and the target falls into a lead pot, ready for removal from the cyclotron

Observations of rotation in JET plasmas with electron heating by ion cyclotron resonance heating

DEFF Research Database (Denmark)

Hellsten, T.; Johnson, T. J.; Van Eester, D.

2012-01-01

The rotation of L-mode plasmas in the JET tokamak heated by waves in the ion cyclotron range of frequencies (ICRF) damped on electrons, is reported. The plasma in the core is found to rotate in the counter-current direction with a high shear and in the outer part of the plasma with an almost......, electron absorption of the fast magnetosonic wave by transit time magnetic pumping and electron Landau damping (TTMP/ELD) is the dominating absorption mechanism. Inverted mode conversion is done in (He-3)-H plasmas where the mode converted waves are essentially absorbed by electron Landau damping. Similar...... rotation profiles are seen when heating at the second harmonic cyclotron frequency of He-3 and with mode conversion at high concentrations of He-3. The magnitude of the counter-rotation is found to decrease with an increasing plasma current. The correlation of the rotation with the electron temperature...

Moderate long-term modulation of neuropeptide Y in hypothalamic arcuate nucleus induces energy balance alterations in adult rats.

Directory of Open Access Journals (Sweden)

Lígia Sousa-Ferreira

Full Text Available Neuropeptide Y (NPY produced by arcuate nucleus (ARC neurons has a strong orexigenic effect on target neurons. Hypothalamic NPY levels undergo wide-ranging oscillations during the circadian cycle and in response to fasting and peripheral hormones (from 0.25 to 10-fold change. The aim of the present study was to evaluate the impact of a moderate long-term modulation of NPY within the ARC neurons on food consumption, body weight gain and hypothalamic neuropeptides. We achieved a physiological overexpression (3.6-fold increase and down-regulation (0.5-fold decrease of NPY in the rat ARC by injection of AAV vectors expressing NPY and synthetic microRNA that target the NPY, respectively. Our work shows that a moderate overexpression of NPY was sufficient to induce diurnal over-feeding, sustained body weight gain and severe obesity in adult rats. Additionally, the circulating levels of leptin were elevated but the immunoreactivity (ir of ARC neuropeptides was not in accordance (POMC-ir was unchanged and AGRP-ir increased, suggesting a disruption in the ability of ARC neurons to response to peripheral metabolic alterations. Furthermore, a dysfunction in adipocytes phenotype was observed in these obese rats. In addition, moderate down-regulation of NPY did not affect basal feeding or normal body weight gain but the response to food deprivation was compromised since fasting-induced hyperphagia was inhibited and fasting-induced decrease in locomotor activity was absent.These results highlight the importance of the physiological ARC NPY levels oscillations on feeding regulation, fasting response and body weight preservation, and are important for the design of therapeutic interventions for obesity that include the NPY.

Use of maze in cyclotron hoppers

International Nuclear Information System (INIS)

Fernandes, Fernando A.; Alves, Juliano S.; Fochesatto, Cintia; Cerioli, Luciane; Borges, Joao Alfredo; Gonzalez, Delfin; Silva, Daniel C.

2013-01-01

Introduction: the increasing number of cyclotrons in Brazil due to constitutional amendment 49 /06 that enabled the production of radiopharmaceuticals with a short half - life by private companies. The radionuclides used for PET - CT require production centers near or within the diagnostic centers. In order to minimize maintenance and operating risks, gaining efficiency, our facility was the first in Brazil to use the access to a cyclotron bunker via maze, rather than armored door stopper type. Materials: the design calculations were based on the Monte Carlo method (MCNP5 - Monte Carlo N-Particletransportcode version 5). At the ends of the labyrinth are installed a door of polyethylene, for thermalization of neutrons, and other of wood for limiting access. Both legs of the maze have wall thickness of 100cm. In inspection Brazilian CNEN realize measures of dose rate for neutrons and gamma 9 points: 7 around the bunker, 1 over the bunker and 1 in the exhaust with the cyclotron operating with maximum load, double beam of 50uA for 2 hours. After commissioning were carried out around the bunker, the following measures: cumulative dose in three months with dosimeters for neutron rate dose with a gas proportional detector type filled with 3 He and polyethylene neutron moderator and dose rate with a Geiger - Mueller detector for gamma radiation. Readings with neutron detectors were classified as background radiation and dose rates were always below the limits established in standard EN 3.01, and the calculation of the predicted regardless of the intensity of irradiation inside the bunker. Conclusion: the use of labyrinths as a way to access the bunkers cyclotron has been shown to be effective as the radiation shielding and efficient by allowing quick and easy access, virtually eliminating the maintenance

Design Study of a Mini Cyclotron for the Application of Biomedical Accelerator Mass Spectrometry

International Nuclear Information System (INIS)

Kim, Jong-Won; Yun, Chong-Chul; Youn, Min-Yong; Wang, Sonjong

2009-01-01

A small cyclotron has been considered for the use of biomedical accelerator mass spectrometer (BAMS). Over a decade ago a few cyclotrons had been constructed and tested for AMS, but technical problems of instability and poor transmission efficiency caused to discontinue further developments. The major reason of the demise of cyclotron AMS was the dominance of commercial Tandem-based AMS facilities. Now BAMS may ask for more compact system, and perhaps using positive ions to accelerate isotope tracers is a favorable feature. The design of a cyclotron to meet the requirements of BAMS has been performed by adopting a compact magnet with high stability and a flat-topping rf system to increase transmission efficiency.

Measurement of fast minority /sub 3/He/sup + +/ energy distribution during ICRF heating

Science.gov (United States)

Post, D.E. Jr.; Grisham, L.R.; Medley, S.S.

A method and means for measuring the fast /sub 3/He/sup + +/ distribution during /sub 3/He/sup + +/ minority Ion Cyclotron Resonance Frequency (ICRF) heating is disclosed. The present invention involves the use of 10 to 100 keV beams of neutral helium atoms to neutralize the fast /sub 3/He/sup + +/ ions in a heated plasma by double charge exchange (/sub 3/He/sup + +/ + /sub 4/He/sup 0/ ..-->.. /sub 3/He/sup 0/ + /sub 4/He/sup + +/). The neutralized fast /sub 3/He/sup 0/ atoms then escape from the hot plasma confined by a magnetic field and are detected by conventional neutral particle analyzing means. This technique permits the effectiveness of the coupling of the ion cyclotron waves to the /sub 3/He/sup + +/ minority ions to be accurately measured. The present invention is particularly adapted for use in evaluating the effectiveness of the intermediate coupling between the RF heating and the /sub 3/He/sup + +/ in an energetic toroidal plasma.

Ion cyclotron emission due to collective instability of fusion products and beam ions in TFTR and JET

International Nuclear Information System (INIS)

Dendy, R.O.; McClements, K.G.; Lashmore Davies, C.N.; Cottrell, G.A.; Majeski, R.; Cauffman, S.

1995-01-01

Ion cyclotron emission (ICE) has been observed from neutral beam heated TFTR and JET tritium experiments at sequential cyclotron harmonics of both fusion products and beam ions. The emission originates from the outer midplane plasma, where fusion products and beam ions are likely to have a drifting ring-type velocity-space distribution that is anisotropic and sharply peaked. Fusion product driven ICE can be attributed to the magnetoacoustic cyclotron instability, which involves the excitation of obliquely propagating waves on the fast Alfven/ion Bernstein branch at cyclotron harmonics of the fusion products. Differences between ICE observations in JET and TFTR appear to reflect the sensitivity of the instability growth rate to the ratio υ birth /c A , where υ birth is the fusion product birth speed and c A is the local Alfven speed: for fusion products in the outer midplane edge of TFTR supershots, υ birth A ; for alpha particles in the outer midplane edge of JET, the opposite inequality applies. If sub-Alfvenic fusion products are isotropic or have undergone even a moderate degree of thermalization, the magnetoacoustic instability cannot occur. In contrast, the super-Alfvenic alpha particles that are present in the outer midplane of JET can drive the magnetoacoustic cyclotron instability even if they are isotropic or have a relatively broad distribution of speeds. These conclusions may account for the observation that fusion product driven ICE in JET persists for longer than fusion product driven ICE in TFTR. A separate mechanism is proposed for the excitation of beam driven ICE in TFTR: electrostatic ion cyclotron harmonic waves, supported by strongly sub-Alfvenic beam ions, can be destabilized by a low concentration of such ions with a very anrrow spread of velocities in the parallel direction. 25 refs, 14 figs

Ion cyclotron emission due to collective instability of fusion products and beam ions in TFTR and JET

International Nuclear Information System (INIS)

Dendy, R.O.; Clements, K.G.; Lashmore-Davies, C.N.; Cottrell, G.A.; Majeski, R.; Cauffman, S.

1995-06-01

Ion cyclotron emission (ICE) has been observed from neutral beam-heated TFTR and JET tritium experiments at sequential cyclotron harmonics of both fusion products and beam ions. The emission originates from the outer mid-plane plasma, where fusion products and beam ions are likely to have a drifting ring-type velocity-space distribution which is anisotropic and sharply peaked. Fusion product-driven ICE in both TFTR and JET can be attributed to the magnetoacoustic cyclotron instability, which involves the excitation of obliquely propagating waves on the fast Alfven/ion Bernstein branch at cyclotron harmonics of the fusion products. Differences between ICE observations in JET and TFTR appear to reflect the sensitivity of the instability growth rate to the ratio υ birth /c A , where υ birth is the fusion product birth speed and c A is the local Alfven speed:for fusion products in the outer midplane edge of TFTR, υ birth A ; for alpha-particles in the outer midplane edge of JET, the opposite inequality applies. If sub-Alfvenic fusion products are isotropic or have undergone even a moderate degree of thermalization, the magnetoacoustic instability cannot occur. In contrast, the super-Alfvenic alpha-particles which are present in the outer mid-plane of JET can drive the magnetoacoustic cyclotron instability even if they are isotropic or have a relatively broad distribution of speeds. These conclusions may account for the observation that fusion product-driven ICE in JET persists for longer than fusion product-driven ICE in TFTR. (Author)

Commissioning of cryogen delivery system for superconducting cyclotron magnet

International Nuclear Information System (INIS)

Pal, G.; Nandi, C.; Bhattacharyya, T.K.; Chaudhuri, J.; Bhandari, R.K.

2005-01-01

A K-500 superconducting cyclotron is being constructed at VECC Kolkata. The cryogen delivery system distributes liquid helium and liquid nitrogen to the superconducting cyclotron. Liquid helium is required to cool the cyclotron magnet and cryopanels. Liquid nitrogen is used to reduce the capacity of the helium liquefier. This paper describes the system, the current status and the commissioning experiences of cryogen delivery system for cyclotron magnet. (author)

Progress report: Variable Energy Cyclotron Centre, Calcutta

International Nuclear Information System (INIS)

1999-01-01

This volume of the progress report brings out the scientific and technical activities of Variable Energy Cyclotron Centre, Calcutta during the year 1999. This includes brief review of the various R and D activities of the Centre and outside users of the cyclotron from the universities and other research institutes. The operational activities of the cyclotron with ECR ion sources, accelerator oriented research activities, activities on detector, target and electronics are reported. The activities of the Computer and Informatics group are described. The status report of the ongoing projects is also provided. The main activities of the superconducting cyclotron project, radioactive ion beam project, heavy ion experimental facility, advanced computational facility, recovery and analysis of helium from hot springs and material science research are described

Microwave power coupling with electron cyclotron resonance ...

Indian Academy of Sciences (India)

600 W microwave power with an average electron density of ∼ 6 × 1011 cm. −3 ... the angular frequency of the cyclotron motion, e is the electron charge, m is the mass of .... is also suitable for ECR plasma-based applications like high-quality ...

10 GHz ECRIS for Warsaw Cyclotron

CERN Document Server

Sudlitz, K

1999-01-01

Cusp type, 10 GHz ECRIS has been built and tested earlier. For obtaining intensive beams, more relevant for cyclotron, cusp geometry has been replaced by hexapole. Discharge chamber (stainless steel, 50 mm diameter, 250 mm long) is an extension of a coaxial line, feeding RF (9,6 GHz, up to 200 W) to the plasma. The NdFeB hexapole (0,52 T on the surface) has been used. The axial magnetic field is created by water cooled coils. The axial injection line dedicated to K160 isochronous heavy ion cyclotron has been constructed. The line consists of Glaser lenses, double focusing magnet, solenoid and mirror type inflector. The system provides sufficient transmission of the beam from ECR ion source to the firsts orbits of the cyclotron for m/q ranging from 7 to 2. After successful initial tests which were done in July 1997 the ECRIS serves as an external source for Warsaw Cyclotron.

Ion cyclotron heating in TMX-U

International Nuclear Information System (INIS)

Dimonte, G.; Barter, J.; Romesser, T.; Molvik, A.W.; Cummins, W.F.; Falabella, S.; Poulsen, P.

1987-01-01

Ion cyclotron heating (ICH) is applied to TMX-U to improve the thermal barrier performance by reducing the passing ion collisionality. During its development, measurements of the antenna loading resistance, R p , and the absorption efficiency, η, were compared with calculations with the antenna design code ANTENA over a wide range of densities and frequencies. Good agreement in R p was obtained in the short wavelength slow wave regime but not for long wavelength fast waves because the experimental magnetic field gradients are not modelled in ANTENA. Similarly, η is much larger experimentally (40%) than in ANTENA (10%) due to the magnetic beach in TMX-U. In its application, ICH successfully decreased the passing ion collisionality tenfold but did not extend thermal barrier plugging to higher density, indicating that collisional barrier filling is not currently limiting TMX-U performance. (author). 23 refs, 23 figs

Electron cyclotron harmonic wave acceleration

Science.gov (United States)

Karimabadi, H.; Menyuk, C. R.; Sprangle, P.; Vlahos, L.

1987-01-01

A nonlinear analysis of particle acceleration in a finite bandwidth, obliquely propagating electromagnetic cyclotron wave is presented. It has been suggested by Sprangle and Vlahos in 1983 that the narrow bandwidth cyclotron radiation emitted by the unstable electron distribution inside a flaring solar loop can accelerate electrons outside the loop by the interaction of a monochromatic wave propagating along the ambient magnetic field with the ambient electrons. It is shown here that electrons gyrating and streaming along a uniform, static magnetic field can be accelerated by interacting with the fundamental or second harmonic of a monochromatic, obliquely propagating cyclotron wave. It is also shown that the acceleration is virtually unchanged when a wave with finite bandwidth is considered. This acceleration mechanism can explain the observed high-energy electrons in type III bursts.

Electron cyclotron harmonic wave acceleration

International Nuclear Information System (INIS)

Karimabadi, H.; Menyuk, C.R.; Sprangle, P.; Vlahos, L.; Salonika Univ., Greece)

1987-01-01

A nonlinear analysis of particle acceleration in a finite bandwidth, obliquely propagating electromagnetic cyclotron wave is presented. It has been suggested by Sprangle and Vlahos in 1983 that the narrow bandwidth cyclotron radiation emitted by the unstable electron distribution inside a flaring solar loop can accelerate electrons outside the loop by the interaction of a monochromatic wave propagating along the ambient magnetic field with the ambient electrons. It is shown here that electrons gyrating and streaming along a uniform, static magnetic field can be accelerated by interacting with the fundamental or second harmonic of a monochromatic, obliquely propagating cyclotron wave. It is also shown that the acceleration is virtually unchanged when a wave with finite bandwidth is considered. This acceleration mechanism can explain the observed high-energy electrons in type III bursts. 31 references

83-inch cyclotron research program. Final report

International Nuclear Information System (INIS)

Parkinson, W.C.

1983-07-01

In June of 1960 the US Atomic Energy Commission authorized the construction of a modern variable energy cyclotron facility at The University of Michigan to be used for research in nuclear spectroscopy. The Legislature of the State of Michigan made available funds for construction of a building to house the 83-inch cyclotron and auxiliary equipment as well as the University's remodeled 42-inch cyclotron. The research program centered around the 83-inch cyclotron was funded by the AEC and its successors, the Energy Research and Development Administration (ERDA) and the Department of Energy (DOE), from September 1964 through March 1977. The program represented a continuation of the research effort using the 42-inch cyclotron facility which had been supported continuously by the AEC since February 1950. This final report to DOE briefly describes the research facility, the research program, and highlights the principal accomplishments of the effort. It begins with a historical note to place this effort within the context of nuclear physics research in the Department of Physics of the University of Michigan

Recycling and recommissioning a used biomedical cyclotron

International Nuclear Information System (INIS)

Carroll, L.R.; Ramsey, F.; Armbruster, J.; Montenero, M.

2001-01-01

Biomedical Cyclotrons have a very long life, but there eventually comes a time when any piece of equipment has to be retired from service. From time to time, we have the opportunity to help find new homes for used cyclotrons which, with relatively modest overhaul and refurbishment, can have many additional years of productive service, and thus represent a very valuable asset. The reasons for retiring a cyclotron vary, of course, but in our experience it is often due to an institution's changing priorities or changing needs, rather than the due to any fundamental age-related deficiency in the cyclotron itself. In this paper we will report on the relocation and successful restoration of a used TCC CP-42 cyclotron, which was moved from M.D. Anderson Hospital in Houston to Denton, Texas in early 1998, where it is presently being used for R and D and commercial production of biomedical isotopes. Ownership of the machine has been transferred to the University of North Texas; facility, manpower, and operational resources are provided by International Isotopes, Inc

Diagnostic system for the nuclear medicine with baby cyclotron

International Nuclear Information System (INIS)

Kashihara, Masao; Wakasa, Shyuichiro

1982-01-01

The system of cyclotron nuclear medicine consists of ''RI-production by using the cyclotron'', ''production of radio-pharmaceuticals labeled with RI'', ''positron tomography''. On the other hand, Ultra compact cyclotron (Baby cyclotron) itself, RI production technique and positron tomography have been rapidly developed and advanced. We think that these three functions must be balance in the development in order to spread this system into the routine work in the hospital. However, since the technology of the synthesis for the labeled compounds is not so developed so far, more advance can be strongly expected. In this report, construction of the cyclotron nuclear medicine, utility for the practical use of RI produced by using the cyclotron, technique of RI production, and the studies on automated and efficient productions of radio-pharmaceuticals labeled with short-lived positron emitters for medical diagnostic use are described. (author)

CACTUS - a multidetector set-up at the Oslo Cyclotron

International Nuclear Information System (INIS)

Guttormsen, M.; Bjerke, B.; Messelt, S.; Olsen, E.A.; Ramsoey, T.; Rekstad, J.; Tveter, T.S.; Wikne, J.C.; Kownacki, J.

1989-06-01

The design and construction of the multidetector system CACTUS is discussed, and its operation in the context of the Oslo Cyclotron is described. The multidetector system has been initiated to meet the requirements at the Oslo Cyclotron Laboratory in the experimental work on nuclear structure at high intrinsic excitation energy. The laboratory has developed a promising technique based on measuring γ-decay after single nucleon transfer reactions with the use of pγ coincidences. However, a proper interpretation of the experimental results has often been difficult due to low counting rates. One of the most important aims for the new experimental set-up has been to obtain pγ as well as pγγ coincidence spectra with high statistics. The CACTUS detector system which is mounted on the 90 o beam line of the cyclotron, consists of 28 NaI and 2 Ge detectors in combination with 8 Si particle telescopes

Experimental study of changes of skin blister fluid NPY, IL-12, sICAM-1 and GM-CSF levels in patients with vitiligo in progressive stage

International Nuclear Information System (INIS)

Bi Mingye; Huang Haifen

2011-01-01

Objective: To explore the significance of changes of skin blister fluid NPY, IL-12, sICAM-1 and GM-CSF levels in patients with vitiligo in progressive stage. Methods: 80 patients with vitiligo in progressive stage were divided into two groups (vulgaris vitiligo groups : n=54, segmental vitiligo groups : n=26) Their blister fluid levels of NPY and GM-CSF were determined by radioimmunoassay(RIA), and IL-12 and sICAM-1 were determined by enzyme immunoassay. Results: The levels of skin blister fluid NPY were definitely higher in vitiliginous skin than those in non-vitiliginous patches in segmental vitiligo groups (P 0.05). The levels of skin blister fluid IL-12, sICAM-1 and GM-CSF were all obviously higher in vitiliginous skin than that in non-vitiliginous patches in vulgaris vitiligo groups (P 0.05). Conclusion: The changes of skin blister fluid NPY, IL-12, sICAM-1 and GM-CSF levels in vitiliginous skin may be closely related to development of difference type vitiligo patients with vitiligo, determination of 4 indexes might be helpful for studying the pathogenesis and clinical diagnosis of vitiligo. (authors)

DISSIPATION OF PARALLEL AND OBLIQUE ALFVÉN-CYCLOTRON WAVES—IMPLICATIONS FOR HEATING OF ALPHA PARTICLES IN THE SOLAR WIND

Energy Technology Data Exchange (ETDEWEB)

Maneva, Y. G.; Poedts, Stefaan [Centre for Mathematical Plasma Astrophysics, KU Leuven, B-3001 Leuven (Belgium); Viñas, Adolfo F.; Moya, Pablo S.; Wicks, Robert T., E-mail: yana.maneva@wis.kuleuven.be [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States)

2015-11-20

We perform 2.5D hybrid simulations with massless fluid electrons and kinetic particle-in-cell ions to study the temporal evolution of ion temperatures, temperature anisotropies, and velocity distribution functions in relation to the dissipation and turbulent evolution of a broadband spectrum of parallel and obliquely propagating Alfvén-cyclotron waves. The purpose of this paper is to study the relative role of parallel versus oblique Alfvén-cyclotron waves in the observed heating and acceleration of alpha particles in the fast solar wind. We consider collisionless homogeneous multi-species plasma, consisting of isothermal electrons, isotropic protons, and a minor component of drifting α particles in a finite-β fast stream near the Earth. The kinetic ions are modeled by initially isotropic Maxwellian velocity distribution functions, which develop nonthermal features and temperature anisotropies when a broadband spectrum of low-frequency nonresonant, ω ≤ 0.34 Ω{sub p}, Alfvén-cyclotron waves is imposed at the beginning of the simulations. The initial plasma parameter values, such as ion density, temperatures, and relative drift speeds, are supplied by fast solar wind observations made by the Wind spacecraft at 1 AU. The imposed broadband wave spectra are left-hand polarized and resemble Wind measurements of Alfvénic turbulence in the solar wind. The imposed magnetic field fluctuations for all cases are within the inertial range of the solar wind turbulence and have a Kraichnan-type spectral slope α = −3/2. We vary the propagation angle from θ = 0° to θ = 30° and θ = 60°, and find that the heating of alpha particles is most efficient for the highly oblique waves propagating at 60°, whereas the protons exhibit perpendicular cooling at all propagation angles.

DISSIPATION OF PARALLEL AND OBLIQUE ALFVÉN-CYCLOTRON WAVES—IMPLICATIONS FOR HEATING OF ALPHA PARTICLES IN THE SOLAR WIND

International Nuclear Information System (INIS)

Maneva, Y. G.; Poedts, Stefaan; Viñas, Adolfo F.; Moya, Pablo S.; Wicks, Robert T.

2015-01-01

We perform 2.5D hybrid simulations with massless fluid electrons and kinetic particle-in-cell ions to study the temporal evolution of ion temperatures, temperature anisotropies, and velocity distribution functions in relation to the dissipation and turbulent evolution of a broadband spectrum of parallel and obliquely propagating Alfvén-cyclotron waves. The purpose of this paper is to study the relative role of parallel versus oblique Alfvén-cyclotron waves in the observed heating and acceleration of alpha particles in the fast solar wind. We consider collisionless homogeneous multi-species plasma, consisting of isothermal electrons, isotropic protons, and a minor component of drifting α particles in a finite-β fast stream near the Earth. The kinetic ions are modeled by initially isotropic Maxwellian velocity distribution functions, which develop nonthermal features and temperature anisotropies when a broadband spectrum of low-frequency nonresonant, ω ≤ 0.34 Ω p , Alfvén-cyclotron waves is imposed at the beginning of the simulations. The initial plasma parameter values, such as ion density, temperatures, and relative drift speeds, are supplied by fast solar wind observations made by the Wind spacecraft at 1 AU. The imposed broadband wave spectra are left-hand polarized and resemble Wind measurements of Alfvénic turbulence in the solar wind. The imposed magnetic field fluctuations for all cases are within the inertial range of the solar wind turbulence and have a Kraichnan-type spectral slope α = −3/2. We vary the propagation angle from θ = 0° to θ = 30° and θ = 60°, and find that the heating of alpha particles is most efficient for the highly oblique waves propagating at 60°, whereas the protons exhibit perpendicular cooling at all propagation angles

The development of technology for the improvement of cyclotron performance

Energy Technology Data Exchange (ETDEWEB)

Chai, Jong Seo; Kim, Y. S.; Ha, J. H.; Lee, M. Y.; Lee, H. S

1999-05-01

We show the first-order beam optics theory which is a simplified theory that can be used to carry out the initial design of a cyclotron. Based on this, a computer program has been developed to determine main cyclotron parameters such as number of magnet sectors, sector angle, hill and valley fields, and overall size of the cyclotron etc. We then show the result of two-dimensional magnetic field calculation using POISSON program. By using this program, one can determine magnet yoke geometry and the average magnetic fields etc. Finally, the three-dimensional computer program OPERA-3D had been invoked to determine magnet pole tips (i.e. sector). Validity of the design can be seen by investigating magnetic fields, radial and vertical focusing frequencies as a function of the beam energy. In this report, we show the results of cyclotron magnet design. And we designed 72 MHz RF system and ion source system. We tested RF resonance each coupling methods. We show the result of RF design and prototype operation. Our developed ion source is PIG type. We described our design methods and implementation. We report the result of getting negative hydrogen ion.

Technical Note: Building a combined cyclotron and MRI facility: Implications for interference

Energy Technology Data Exchange (ETDEWEB)

Hofman, Mark B. M.; Kuijer, Joost P. A.; Ridder, Jan Willem de; Perk, Lars R.; Verdaasdonk, Rudolf M. [Physics and Medical Technology, VU University Medical Center, Amsterdam 1007 MB (Netherlands) and BV Cyclotron VU, Amsterdam 1081HV (Netherlands)

2013-01-15

Purpose: With the introduction of hybrid PET/MRI systems, it has become more likely that the cyclotron and MRI systems will be located close to each other. This study considered the interference between a cyclotron and a superconducting MRI system. Methods: Interactions between cyclotrons and MRIs are theoretically considered. The main interference is expected to be the perturbation of the magnetic field in the MRI due to switching on or off the magnetic field of the cyclotron. MR imaging is distorted by a dynamic spatial gradient of an external inplane magnetic field larger than 0.5-0.04 {mu}T/m, depending on the specific MR application. From the design of a cyclotron, it is expected that the magnetic fringe field at large distances behaves as a magnetic dipolar field. This allows estimation of the full dipolar field and its spatial gradients from a single measurement. Around an 18 MeV cyclotron (Cyclone, IBA), magnetic field measurements were performed on 5 locations and compared with calculations based upon a dipolar field model. Results: At the measurement locations the estimated and measured values of the magnetic field component and its spatial gradients of the inplane component were compared, and found to agree within a factor 1.1 for the magnetic field and within a factor of 1.5 for the spatial gradients of the field. In the specific case of the 18 MeV cyclotron with a vertical magnetic field and a 3T superconducting whole body MR system, a minimum distance of 20 m has to be considered to prevent interference. Conclusions: This study showed that a dipole model is sufficiently accurate to predict the interference of a cyclotron on a MRI scanner, for site planning purposes. The cyclotron and a whole body MRI system considered in this study need to be placed more than 20 m apart, or magnetic shielding should be utilized.

Method and apparatuses for ion cyclotron spectrometry

Science.gov (United States)

Dahl, David A [Idaho Falls, ID; Scott, Jill R [Idaho Falls, ID; McJunkin, Timothy R [Idaho Falls, ID

2012-03-06

An ion cyclotron spectrometer may include a vacuum chamber that extends at least along a z-axis and means for producing a magnetic field within the vacuum chamber so that a magnetic field vector is generally parallel to the z-axis. The ion cyclotron spectrometer may also include means for producing a trapping electric field within the vacuum chamber. The trapping electric field may comprise a field potential that, when taken in cross-section along the z-axis, includes at least one section that is concave down and at least one section that is concave up so that ions traversing the field potential experience a net magnetron effect on a cyclotron frequency of the ions that is substantially equal to zero. Other apparatuses and a method for performing ion cyclotron spectrometry are also disclosed herein.

Cyclotron radiation by a multi-group method

International Nuclear Information System (INIS)

Chu, T.C.

1980-01-01

A multi-energy group technique is developed to study conditions under which cyclotron radiation emission can shift a Maxwellian electron distribution into a non-Maxwellian; and if the electron distribution is non-Maxwellian, to study the rate of cyclotron radiation emission as compared to that emitted by a Maxwellian having the same mean electron density and energy. The assumptions in this study are: the electrons should be in an isotropic medium and the magnetic field should be uniform. The multi-group technique is coupled into a multi-group Fokker-Planck computer code to study electron behavior under the influence of cyclotron radiation emission in a self-consistent fashion. Several non-Maxwellian distributions were simulated to compare their cyclotron emissions with the corresponding energy and number density equivalent Maxwellian distribtions

The RBE of Fractionated Fast Neutron on Walker 256 Carcinosarcoma with KCCH-Cyclotron

International Nuclear Information System (INIS)

Yoo, Seong Yul; Koh, Kyoung Hwan; Cho, Chul Koo; Park, Charn Il; Kang, Wee Saing

1987-01-01

For evaluation of biological effect of p+(50.5 MeV) Be neutron beam produced by Korea Cancer Center Hospital(KCCH) cyclotron the RBE had been measured in experimental tumor Walker 256 carcinosarcoma as well as normal tissue, mouse intestine and bone marrow, in single and fractionated irradiation. As pilot study, the RBE had been measured for the mouse jejunal crypt cells in single whole body irradiation of which the result was 2.8. The obtained RBE values of TCD 50 of Walker 256 tumor, bone marrow and intestine in single irradiation were 1.9, 1.9 and 1.5 respectively. In fractionated irradiation, the RBE value of tumor Walker 256 was decreased as increasing of fraction number and increased as increasing of fraction size

Low energy cyclotron for radiocarbon dating

International Nuclear Information System (INIS)

Welch, J.J.

1984-12-01

The measurement of naturally occurring radioisotopes whose half lives are less than a few hundred million years but more than a few years provides information about the temporal behavior of geologic and climatic processes, the temporal history of meteoritic bodies as well as the production mechanisms of these radioisotopes. A new extremely sensitive technique for measuring these radioisotopes at tandem Van de Graaff and cyclotron facilities has been very successful though the high cost and limited availability have been discouraging. We have built and tested a low energy cyclotron for radiocarbon dating similar in size to a conventional mass spectrometer. These tests clearly show that with the addition of a conventional ion source, the low energy cyclotron can perform the extremely high sensitivity 14 C measurements that are now done at accelerator facilities. We found that no significant background is present when the cyclotron is tuned to accelerate 14 C negative ions and the transmission efficiency is adequate to perform radiocarbon dating on milligram samples of carbon. The internal ion source used did not produce sufficient current to detect 14 C directly at modern concentrations. We show how a conventional carbon negative ion source, located outside the cyclotron magnet, would produce sufficient beam and provide for quick sampling to make radiocarbon dating milligram samples with a modest laboratory instrument feasible

Neuropeptide Y enhances olfactory mucosa responses to odorant in hungry rats.

Science.gov (United States)

Negroni, Julia; Meunier, Nicolas; Monnerie, Régine; Salesse, Roland; Baly, Christine; Caillol, Monique; Congar, Patrice

2012-01-01

Neuropeptide Y (NPY) plays an important role in regulating appetite and hunger in vertebrates. In the hypothalamus, NPY stimulates food intake under the control of the nutritional status. Previous studies have shown the presence of NPY and receptors in rodent olfactory system, and suggested a neuroproliferative role. Interestingly, NPY was also shown to directly modulate olfactory responses evoked by a food-related odorant in hungry axolotls. We have recently demonstrated that another nutritional cue, insulin, modulates the odorant responses of the rat olfactory mucosa (OM). Therefore, the aim of the present study was to investigate the potential effect of NPY on rat OM responses to odorants, in relation to the animal's nutritional state. We measured the potential NPY modulation of OM responses to odorant, using electro-olfactogram (EOG) recordings, in fed and fasted adult rats. NPY application significantly and transiently increased EOG amplitudes in fasted but not in fed rats. The effects of specific NPY-receptor agonists were similarly quantified, showing that NPY operated mainly through Y1 receptors. These receptors appeared as heterogeneously expressed by olfactory neurons in the OM, and western blot analysis showed that they were overexpressed in fasted rats. These data provide the first evidence that NPY modulates the initial events of odorant detection in the rat OM. Because this modulation depends on the nutritional status of the animal, and is ascribed to NPY, the most potent orexigenic peptide in the central nervous system, it evidences a strong supplementary physiological link between olfaction and nutritional processes.

PIXE analysis by baby cyclotron

International Nuclear Information System (INIS)

Yoshida, Hyogo; Tanaka, Teruaki; Ito, Takashi; Toda, Yohjiro; Wakasa, Hideichiro

1988-01-01

The Japan Steel Works, Ltd. has been supplying a very small sized cyclotron (Baby Cyclotron) to hospitals and research facilities. The cyclotron is designed to produce short-lived radioisotopes for medical use. In the present study, this cyclotron is modified so that it can serve for PIXE analysis. The PIXE (particle induced X-ray emission) technique has the following features: (1) Down to 1 ng of trace material in a sample (mg - μg) can be detected, (2) An analysis run is completed in one to ten minutes, permitting economical analysis for a large number of samples, (3) Several elements can be analyzed simultaneously, with an almost constant sensitivity for a variety of elements ranging from aluminum to heavy metals, (4) Analysis can be performed nondestructively without a chemical process, and (5) The use of microbeam can provide data on the distribution of elements with a resolution of several μm. Software for analysis is developed to allow the modified equipment to perform peak search, background fitting, and identification and determination of peaks. A study is now being conducted to examine the performance of the equipment for PIXE analysis of thin samples. Satisfactory results have been obtained. The analysis time, excluding the background correction, is 5-10 min. (Nogami, K.)

Operation of the Karlsruhe Isochronous Cyclotron in 1975

International Nuclear Information System (INIS)

Schulz, F.; Schweickert, H.

1976-06-01

The operation of the Karlsruhe Isochronous Cyclotron in 1975 is briefly surveyed. The main reasons for a very short period for maintenance, repair and installation, and several additional efforts to improve the reliability of the accelerator installation, are discussed. The status and the results of several technical developments for the cyclotron are described: 1) the axial injection system; 2) computer aided cyclotron operation; 3) ion source development; 4) capacitive current measurement at the external beam; 5) new correction coils for the cyclotron; 6) improvement of the neutron time-of-flight spectrometer. As there is an increasing interest in using this type of accelerator for research in fields other than nuclear physics, it was felt appropriate to present short surveys on investigations at our cyclotron in 1975 in the fields of: 1) solid state physics; 2) engineering; 3) materials research; 4) nuclear medicine; 5) nuclear chemistry. (orig.) [de

Dynamics of fast ions in Tokamaks

International Nuclear Information System (INIS)

Helander, P.

1994-01-01

Fast ions play a prominent role in the heating of tokamak plasmas by, e.g. neutral-beam injection, ion-cyclotron-resonance heating, and alpha-particle heating. In this thesis, a number of physical and mathematical problems concerning the dynamics of fast ions in tokamaks are addressed. First, the motion under adiabatic perturbations is studied. The frequencies of instabilities excited in tokamaks sometimes vary slowly with time. The existence of an adiabatic invariant of particle motion in such circumstances is shown to lead to a rapid convection of particles in the radial direction. Generalized adiabatic invariants are constructed for systems where the slowly varying parameter is subjected to small, but rapidly varying, fluctuations. Second, the onset of stochastic motion under resonant perturbations is considered. It is shown that the finite width of fast-ion drift orbits significantly affects the threshold for stochastic motion caused by magnetic field ripple or ion-cyclotron-resonance heating. Finite-orbit-width effects are also shown to reduce the strength of resonant interaction between alpha particles and internal kink modes. Third, the diffusive motion in the stochastic regime is analysed mathematically. Monte Carlo operators for the motion on long time-scales are constructed, and the validity of the quasilinear diffusion coefficient is examined. Finally, the effects of close ion collisions are investigated. It is demonstrated that close encounters with fast ions produce a high-energy tail in the distribution functions of impurity ions, and that close collisions between fusion-generated alpha particles give rise to a population of such particles with energies extending up to twice the birth energy. 44 refs

Gaseous radioactive effluent restrictions, measurement, and minimization at a PET/cyclotron facility

International Nuclear Information System (INIS)

Plascjak, P.S.; Kim, K.K.; Googins, S.W.; Meyer, W.C. Jr.

1993-01-01

In the US, restrictions on the release of radioactive effluents from PET (positron emission tomography)/cyclotron facilities are typically imposed by State regulatory agencies and may be based on various methodologies and limits published by numerous agencies. This work presents suitable effluent concentration limits for various chemical forms of radioisotopes routinely produced in PET/cyclotron facilities. They were determined by application of metabolic models defined by ICRP 53 and ICRP 26/30 which will result in compliance with effective dose equivalent limits of 100 mrem per year at the release point. The NIH Cyclotron Facility effluent air monitoring system, environmental dosimetry program, and simple, effective systems for radioactive effluent minimization are also described. (orig.)

Present and future superconducting cyclotrons

International Nuclear Information System (INIS)

Nolen, J.A. Jr.

1987-01-01

This paper begins with a brief review of the status of present superconducting (SC) cyclotron projects, including the two which are currently operating and the six which are under construction. The next section summarizes the main features shared by five of these machines, while the third section presents recent developments and new concepts introduced in the other three ''second generation'' SC cyclotrons. Projects in early stages of development are discussed in the fourth section

NIRS-Chiba isochronous cyclotron 1975

International Nuclear Information System (INIS)

Ogawa, H.; Kumamoto, Y.; Yamada, T.; Hiramoto, T.

1976-02-01

The cyclotron facility installed according to the recommendation of the Atomic Energy Committee of Japan is used for neutron therapy and production of short-lived radioisotopes. Construction on the facility was started in the autumn of 1972, and completed in March 1974. Described are the following: beam transport and the experimental hall, machine research and improvement, machine time sharing and the particles and energies, characteristics of the cyclotron, and facility personnel. (auth.)

Isochronous cyclotron for thermonuclear reactors driving

International Nuclear Information System (INIS)

Alenitskij, Yu.G.

1998-01-01

The main requirements to an accelerator as a part of an electronuclear power plant are considered. The range of the parameters of the accelerated proton and deuteron beams, for which the isochronous cyclotron is the most profitable, is proposed. An opportunity of using the cyclotron to drive the research reactors of various types is considered

Cyclotron to Oslo University

International Nuclear Information System (INIS)

Sandstad, J.

1978-01-01

The new cyclotron was delivered to Oslo University on September 21st 1978, and was mannfactured by A/B Scandtronix of Uppsala, Sweden. The contract price was 6,8 million Norwegian kroner and installation will cost a further 4 million. The main specifications are given. The energy will be 36 MeV for protons and alpha particles, 18 MeV deuterons and 48 MeV for helium 3. The principle of a cyclotron is briefly described. While the primary purpose of the machine is nuclear research it is also planned to produce short-lived radioisotopes, primarily iodine 123. (JIW)

Effect of ion clouds micromotion on measured signal in Fourier transform ion cyclotron resonance: Computer simulation.

Science.gov (United States)

Vladimirov, Gleb; Kostyukevich, Yury; Kharybin, Oleg; Nikolaev, Eugene

2017-08-01

Particle-in-cell-based realistic simulation of Fourier transform ion cyclotron resonance experiments could be used to generate ion trajectories and a signal induced on the detection electrodes. It has been shown recently that there is a modulation of "reduced" cyclotron frequencies in ion cyclotron resonance signal caused by Coulomb interaction of ion clouds. In this work it was proposed to use this modulation in order to determine frequency difference between an ion of known m/z and all other ions generating signal in ion cyclotron resonance cell. It is shown that with an increase of number of ions in ion cyclotron resonance trap, the modulation index increases, which lead to a decrease in the accuracy of determination of peak intensities by super Fourier transform resolution methods such as filter diagonalization method.

Cyclotron for industrial production of radioisotopes: relevants characteristics

International Nuclear Information System (INIS)

Lima, Wanderley de

1997-01-01

The industrial production of radioisotopes requests cyclotrons with easy maintenance services, high productivity and low operation costs. To obtain this performance the experts on the have achieved excellent results, taking advantage of modern resources in calculation and modeling. Only by the maximum exploitation of the azimutal variation of the magnetic field, a physical concept introduced in 1967 with the isocronous cyclotrons, it was possible to construct cyclotrons with only 30% of the electrical consumption required by the former cyclotrons. On the other hand, the acceleration of negative ions enable the 100% accelerated beam utilization, without internal energy dissipation, obtaining beam intensities up to 1mA in continuous running which represents an increased factor of 15. Other construction parameters were optimized aiming at reliability and reduction in the components activation. Concerning energy consumption and the beam intensity supplied, a present cyclotron with 30 MeV and 300μA of protons current is 15 times more efficient than its precedent. (author). 6 refs., 1 fig., 2 tabs

Present situation of 'baby cyclotron'

International Nuclear Information System (INIS)

Yamada, Teruo

1981-01-01

A ''baby cyclotron'' has been developed by the Japan Steel Works, Ltd. Its No. 1 model (proton 9.4 MeV) was delivered to the Nakano Hospital of National Sanatorium in March, 1979. It is being used successfully for the production of 11 C, 13 N and 15 O and labeled compounds. The proton or deuteron particles accelerated in the cyclotron collide on target materials. The target box, which is automatically changeable, is directly installed to the accelerating box, thereby taking the safety measures for any leaking radiation. The following matters are described: the production of short-lived radioisotopes (RI yields and treatment); the processes of production in the Nakano Hospital, with No. 1 baby cyclotron, including the photosynthesis of labeled compounds such as 11 C-labeled glucose; the research on the automation in the synthesis of organic labeled compounds like 11 C-palmitic acid. (J.P.N.)

Cryogenic system for VECC K500 superconducting cyclotron

CERN Document Server

Pal, G; Bhattacharyya, T K; Bhandari, R K

2009-01-01

VEC Centre, Kolkata in India is at an advanced stage of commissioning a K500 superconducting cyclotron. The superconducting coil of the magnet for cyclotron is cooled by liquid helium. Three liquid helium cooled cryopanels, placed inside the Dees of the radiofrequency system, maintain the vacuum in the acceleration region of the superconducting cyclotron. The cryogenic system for magnet for cyclotron has been tested by cooling the coil and energizing the magnet. The cryogenic system for cryopanels has also been tested. Heater and temperature sensor were placed on the liquid helium cold head for cryopanel. The temperature of the cold head was observed to be below 20 K upto a heat load of 11.7 watt.

The Berkeley Accelerator Space Effects (BASE) Facility - A new mission for the 88-Inch Cyclotron at LBNL

International Nuclear Information System (INIS)

McMahan, M.A.

2005-01-01

In FY04, the 88-Inch Cyclotron began a new operating mode that supports a local research program in nuclear science, R and D in accelerator technology and a test facility for the National Security Space (NSS) community (the US Air Force and NRO). The NSS community (and others on a cost recovery basis) can take advantage of both the light- and heavy-ion capabilities of the cyclotron to simulate the space radiation environment. A significant portion of this work involves the testing of microcircuits for single event effects. The experimental areas within the building that are used for the radiation effects testing are now called the Berkeley Accelerator Space Effects (BASE) Facility. Improvements to the facility to provide increased reliability, quality assurance and new capabilities are underway and will be discussed. These include a 16 A MeV 'cocktail' of beams for heavy ion testing, a neutron beam, more robust dosimetry, and other upgrades

Nonlinear cyclotron absorption and stimulated scattering

International Nuclear Information System (INIS)

Chung, T.H.

1986-01-01

In electron cyclotron resonance heating (ECRH), wave sources heating a plasma linearly with respect to intensity; but as the intensity of ECRH gets larger, there might appear nonlinear effects that would result in cutoff of net absorption. This thesis uses quantum mechanical theory to derive a threshold microwave intensity for nonlinear absorption. The quantum mechanical theory estimates that the threshold microwave intensity for nonlinear absorption is about 10 5 watts/cm 2 for a microwave heating experiment (T/sub e/ = 100 ev, λ = 3,783 cm, B = 2.5 kG). This value seems large considering the present power capabilities of microwave sources (10 2 ∼ 10 3 watts/cm 2 ), but for a low temperature plasma, this threshold will go down. There is another nonlinear phenomenon called stimulated cyclotron scattering that enhances photon scattering by electrons gyrating in a magnetic field. This is expected to prevent incoming photons from arriving at the central region of the fusion plasma, where absorption mainly takes place. Theory based on a photon transport model predicts that the threshold intensity for the stimulated cyclotron scattering is about 10 4 watts/cm 2 for the plasma parameters mentioned above. This value seems large also, but a longer wavelength of microwaves and a larger magnitude magnetic field, which will be the case in reactor type facilities, will lower the threshold intensity to levels comparable with the currently developed microwave sources

Concept of the detuned primary coupling and model measurements for the radiofrequency system of the VINCY cyclotron

International Nuclear Information System (INIS)

Bojovic, B.; Susini, A.

1999-01-01

A new concept of the impedance matching of a radiofrequency (RF) amplifier (primary) coupled to a cyclotron RF cavity (secondary) is discussed. In this arrangement the necessity of moving the coupling loop in vacuum is avoided, and the impedance matching for different operating frequencies is performed only by a variable capacitor. A design procedure based on the transformer equations is proposed, and the design of the RF system of the VINCY Cyclotron, the main part of the TESLA Accelerator Installation, based on the concept of the detuned primary coupling is presented. The measurements on a 1:1 scale model of the RF system of the VINCY Cyclotron were carried out for the whole range of the operating frequencies. The results obtained confirmed the viability of the coupling concept for the cyclotron RF systems. (authors)

Variable-Energy Cyclotron for Proton Therapy Application

CERN Document Server

Alenitsky, Yu G; Vorozhtsov, A S; Glazov, A A; Mytsyn, G V; Molokanov, A G; Onishchenko, L M

2004-01-01

The requirements to characteristics of the beams used for proton therapy are considered. The operation and proposed cyclotrons for proton therapy are briefly described. The technical decisions of creation of the cyclotron with energy variation in the range 70-230 MeV and with current up to 100 nA are estimated. Taking into account the fact, that the size and cost of the cyclotron are approximately determined by the maximum proton energy, it is realistically offered to limit the maximum proton energy to 190 MeV and to elaborate a cyclotron project with a warm winding of the magnet for acceleration of H^{-} ions. The energy of the extracted protons for each run is determined by a stripped target radius in the vacuum chamber of the accelerator, and the radiation dose field for the patient is created by the external devices using the developed techniques.

Radiation exposure to workers at cyclotron facilities

International Nuclear Information System (INIS)

Ribeiro, M.S.; Sanches, M.P.; Sanchez, A.S.; Rodrigues, D.L.

2001-01-01

Radiopharmaceuticals quickly furnish the information doctors need to establish a precise diagnosis of the patient's condition, and therefore to prescribe the most effective therapy. In cancerology, F18-FDG, the most widely used PET imaging tracer, excels in the early detection of cancer tumors, even very tiny ones, which it locates and clearly distinguishes from healthy surrounding tissues. IPEN-CNEN/SP has two cyclotron accelerators used mainly for radioisotope production to be utilized in nuclear medicine for diagnosis and therapy. The first is a CV-28 cyclotron, variable energy that came into operation in 1982, which was used to produce F18-FDG and Iodine 123 up to 1998. The second, a Cyclone 30 cyclotron, 30 MeV, commenced operation in 1998 for certification purpose, and due to increase demand for radiopharmaceuticals in Brazil, started F18-FDG production in 1999. Cyclotron Laboratory will be a reference Research and Developing Center in our country and will help the Brazilian and Latin-American community. It is necessary to have an adequate database to allow regular follow up and analysis of the individual dose distributions for each group involved in the cyclotron activities. These databases are also important means to assess the effectiveness of efforts in order to maintain doses ALARA and reduce inequalities. The official individual occupational dosimetry is provided by certified Laboratory of Thermoluminescent Dosimetry at IPEN-CNEN/SP. This paper describes the occupational doses distribution in Laboratory of Cyclotrons at IPEN-CNEN/SP from January, 1998 to July, 2000 and propose improvements for the future. (author)

Neutron field inside a PET Cyclotron vault room

International Nuclear Information System (INIS)

Vega C, H.R.; Mendez, R.; Iniguez, M.P.; Climent, J.M.; Penuelas, I.; Barquero, R.

2006-01-01

The neutron field around a Positron Emission Tomography cyclotron was investigated during 18 F radioisotope production with an 18 MeV proton beam. In this study the Ion Beam Application cyclotron, model Cyclone 18/9, was utilized. Measurements were carried out with a Bonner sphere neutron spectrometer with pairs of thermoluminescent dosemeters (TLD600 and TLD700) as thermal neutron detector. The TLDs readouts were utilized to unfold the neutron spectra at three different positions inside the cyclotron's vault room. With the spectra the Ambient dose equivalent was calculated. Neutron spectra unfolding were performed with the BUNKIUT code and the UTA4 response matrix. Neutron spectra were also determined by Monte Carlo calculations using a detailed model of cyclotron and vault room. (Author)

Radiation protection and safety culture for cyclotron workers

International Nuclear Information System (INIS)

Gomaa, M.A.

1998-01-01

The main aim of the present study is to review radiation protection and safety culture measures to be applied to cyclotron workers. The radiation protection (measures are based on Basic Safety standards for the protection) of the health of workers and the general public against the dangers arising from ionizing radiation, while the safety culture are based on IAEA publications

Ramifide resonators for cyclotrons

International Nuclear Information System (INIS)

Smirnov, Yu.V.

2000-01-01

The resonators with the conductors ramified form for cyclotrons are systematized and separated into the self-contained class - the ramified resonators for cyclotrons (Carr). The ramified resonators are compared with the quarter-wave and half-wave nonramified resonators, accomplished from the transmitting lines fragments. The CRR are classified into two types: ones with the additional structural element, switched in parallel and in series. The CRR may include several additional structural elements. The CRR calculations may be concluded by analytical methods - the method of matrix calculation or the method of telegraph equations and numerical methods - by means of the ISFEL3D, MAFIA and other programs [ru

Hyperphagia of hyperthyroidism: is neuropeptide Y involved?

Science.gov (United States)

Pétervári, Erika; Balaskó, Márta; Jech-Mihálffy, Andrea; Székely, Miklós

2005-11-01

The possible role of neuropeptide Y (NPY) was studied in rats with hypermetabolism and hyperphagia induced by thyroxine (50-100-200 microg/day s.c. for 3-4 weeks). Both metabolic rate and body temperature increased quickly with thyroxine treatment, while hyperphagia started to develop only after 2 weeks of treatment. The weight gain rate progressively decreased or stopped. The NPY-induced hyperphagia was not altered significantly during thyroxine treatment (in severe thyrotoxicosis it was rather suppressed); the fasting-induced hyperphagia was smaller than in controls following 1 week of treatment, and it became enhanced only after 3 weeks, when the deficit in body weight indicated a certain level of starvation already prior to the food deprivation. The NPY-antagonist D-Tyr27,36,D-Thr32-NPY27,36 suppressed this fasting-induced hyperphagia, suggesting that endogenous NPY is involved in this late phase. In conclusion, hyperthyroidism per se does not increase the NPY activity, instead the quickly developing hyperthermia may inhibit the NPY actions; NPY may, however, be activated by a concurrent hypermetabolism-induced starvation.

Radioisotope production with a medical cyclotron

International Nuclear Information System (INIS)

Silvester, D.J.

1974-01-01

The cyclotron of Hammersmith hospital in England was completed and started the operation in 1955. The feature is in its design operable at high beam current, reaching 500μA in internal beam and 300μA in external beam. In 1960's, twelve nuclides of radioactive pharmaceuticals were produced with the cyclotron. C-11, N-13 and O-15 have been used in the form of radioactive gases such as CO or H 2 O to test lung functions. F-18 has been used for bone scanning. K-43 is employed in the research of electrolyte balancing together with Na-24 and Br-77. Fe-52 is utilized in iron ion researches as a tracer. Cs-129 is highly evaluated as an isotope for imaging cardiac clogging part. Radioisotopes must be much more used in the examination of in vivo metabolic function. For this purpose, peculiarly labelled compounds should be further developed. It is welcome that the persons paying attention to the medical prospect of cyclotrons are increasing. The author hopes to continue his endeavour to find new products made with the cyclotron for human welfare. (Wakatsuki, Y.)

Second harmonic ion cylotron resonance heating by the fast magnetosonic wave on the PLT tokamak

International Nuclear Information System (INIS)

Thompson, H.R. Jr.

1984-01-01

Second harmonic ion cyclotron resonance heating by the fast magnetosonic wave, and the propagation of the fast wave from the fundamental of the ion cyclotron frequency to its second harmonic was investigated in a hydrogen plasma on the PLT tokamak. The theory of fast magnetosonic wave propagation was extended to include the effects of density gradients, plasma current, and impurity ion species. The damping of the fast wave at the second harmonic is calculated, where the theory has been extended to include the full radial dependence of the fast wave fields. Power deposition profiles and eigenmode Q's are calculated using this theory. The effects of the interaction between the ion Bernstein wave and the fast magnetosonic wave are calculated, and enhanced fast wave damping is predicted. The antenna loading is calculated including the effects of overlap of the fast wave eigenmodes. During the second harmonic heating experiments, the antenna loading was characterized as a function of the plasma parameters, and efficient coupling of the RF power to the plasma at high density was observed. At very low densities, fast wave eigenmodes were identified on PLT, and their Q's are measured. Eigenmodes with different toroidal directions of propagation were observed to exhibit large splitting in density due to the plasma current. Efficient bulk heating, with centrally peaked profiles, is observed at the second harmonic, and a tail, which decreases monotonically with energy, is observed on the ion distribution

NORTICA - a new code for cyclotron analysis

International Nuclear Information System (INIS)

Gorelov, D.; Johnson, D.; Marti, F.

2001-01-01

The new package NORTICA (Numerical ORbit Tracking In Cyclotrons with Analysis) of computer codes for beam dynamics simulations is under development at NSCL. The package was started as a replacement for the code MONSTER developed in the laboratory in the past. The new codes are capable of beam dynamics simulations in both CCF (Coupled Cyclotron Facility) accelerators, the K500 and K1200 superconducting cyclotrons. The general purpose of this package is assisting in setting and tuning the cyclotrons taking into account the main field and extraction channel imperfections. The computer platform for the package is Alpha Station with UNIX operating system and X-Windows graphic interface. A multiple programming language approach was used in order to combine the reliability of the numerical algorithms developed over the long period of time in the laboratory and the friendliness of modern style user interface. This paper describes the capability and features of the codes in the present state

NORTICA—a new code for cyclotron analysis

Science.gov (United States)

Gorelov, D.; Johnson, D.; Marti, F.

2001-12-01

The new package NORTICA (Numerical ORbit Tracking In Cyclotrons with Analysis) of computer codes for beam dynamics simulations is under development at NSCL. The package was started as a replacement for the code MONSTER [1] developed in the laboratory in the past. The new codes are capable of beam dynamics simulations in both CCF (Coupled Cyclotron Facility) accelerators, the K500 and K1200 superconducting cyclotrons. The general purpose of this package is assisting in setting and tuning the cyclotrons taking into account the main field and extraction channel imperfections. The computer platform for the package is Alpha Station with UNIX operating system and X-Windows graphic interface. A multiple programming language approach was used in order to combine the reliability of the numerical algorithms developed over the long period of time in the laboratory and the friendliness of modern style user interface. This paper describes the capability and features of the codes in the present state.

Fast-ion dynamics in the TEXTOR tokamak measured by collective Thomson scattering

DEFF Research Database (Denmark)

Bindslev, H.; Nielsen, S.K.; Porte, L.

2006-01-01

Here we present the first measurements by collective Thomson scattering of the evolution of fast-ion populations in a magnetically confined fusion plasma. 150 kW and 110 Ghz radiation from a gyrotron were scattered in the TEXTOR tokamak plasma with energetic ions generated by neutral beam injection...... and ion cyclotron resonance heating. The temporal behavior of the spatially resolved fast-ion velocity distribution is inferred from the received scattered radiation. The fast-ion dynamics at sawteeth and the slowdown after switch off of auxiliary heating is resolved in time. The latter is shown...

Real-time control of tearing modes using a line-of-sight electron cyclotron emission diagnostic

International Nuclear Information System (INIS)

Hennen, B A; Westerhof, E; De Baar, M R; Bongers, W A; Thoen, D J; Nuij, P W J M; Steinbuch, M; Oosterbeek, J W; Buerger, A

2010-01-01

The stability and performance of tokamak plasmas are limited by instabilities such as neoclassical tearing modes. This paper reports on an experimental proof of principle of a feedback control approach for real-time, autonomous suppression and stabilization of tearing modes in a tokamak. The system combines an electron cyclotron emission diagnostic for sensing of the tearing modes in the same sight line with a steerable electron cyclotron resonance heating and current drive (ECRH/ECCD) antenna. A methodology for fast detection of q = m/n = 2/1 tearing modes and retrieval of their location, rotation frequency and phase is presented. Set-points to establish alignment of the ECRH/ECCD deposition location with the centre of the tearing mode are generated in real time and forwarded in closed loop to the steerable launcher and as a modulation pulse train to the gyrotron. Experimental results demonstrate the capability of the control system to track externally perturbed tearing modes in real time.

FAST Plasma Scenarios and Equilibrium Configurations

International Nuclear Information System (INIS)

Calabro, G.; Crisanti, F.; Ramogida, G.; Cardinali, A.; Cucchiaro, A.; Maddaluno, G.; Pizzuto, A.; Pericoli Ridolfini, V.; Tuccillo, A.A.; Zonca, F.; Albanese, R.; Granucci, G.; Nowak, S.

2008-01-01

In this paper we present the Fusion Advanced Studies Torus (FAST) plasma scenarios and equilibrium configurations, designed to reproduce the ITER ones (with scaled plasma current) and suitable to fulfil plasma conditions for integrated studies of burning plasma physics, Plasma Wall interaction, ITER relevant operation problems and Steady State scenarios. The attention is focused on FAST flexibility in terms of both performance and physics that can be investigated: operations are foreseen at a wide range of parameters from high performance H-Mode (toroidal field, B T , up to 8.5 T; plasma current, I P , up to 8 MA) to advanced tokamak (AT) operation (I P =3 MA) as well as full non inductive current scenario (I P =2 MA). The coupled heating power is provided with 30MW delivered by an Ion Cyclotron Resonance Heating (ICRH) system (30-90MHz), 6 MW by a Lower Hybrid (LH) system (3.7 or 5 GHz) for the long pulse AT scenario, 4 MW by an Electron Cyclotron Resonant Heating (ECRH) system (170 GHz-B T =6T) for MHD and electron heating localized control and, eventually, with 10 MW by a Negative Ion Beam (NNBI), which the ports are designed to accommodate. In the reference H-mode scenario FAST preserves (with respect to ITER) fast ions induced as well as turbulence fluctuation spectra, thus, addressing the cross-scale couplings issue of micro- to meso-scale physics. The noninductive scenario at I P =2MA is obtained with 60-70 % of bootstrap and the remaining by LHCD. Predictive simulations of the H-mode scenarios described above have been performed by means of JETTO code, using a semi-empirical mixed Bohm/gyro-Bohm transport model. Plasma position and Shape Control studies are also presented for the reference scenario

Considerations, measurements and logistics associated with low-energy cyclotron decommissioning

International Nuclear Information System (INIS)

Sunderland, J. J.; Erdahl, C. E.; Bender, B. R.; Sensoy, L.; Watkins, G. L.

2012-01-01

The University of Iowa’s 20-year-old 17 MeV Scanditronix cyclotron underwent decommissioning in the summer of 2011. To satisfy local, state and federal regulations defining removal, transportation and long-term safe and environmentally secure disposal of the 22 ton activated cyclotron, a series of nuclear spectroscopic measurements were performed to characterize the nature and extent of proton and neutron activation of the 22-ton cyclotron, its associated targets, and the concrete wall that was demolished to remove the old cyclotron. Neutron activation of the concrete wall was minimal and below exempt concentrations resulting in standard landfill disposal. The cyclotron assessment revealed the expected array of short and medium-lived radionuclides. Subsequent calculations suggest that meaningful levels residual activity will have decayed virtually to background after 15 years, with the total residual activity of the entire cyclotron dropping below 37 MBq (1 mCi).

MM-wave cyclotron auto-resonance maser for plasma heating

Science.gov (United States)

Ceccuzzi, S.; Dattoli, G.; Di Palma, E.; Doria, A.; Gallerano, G. P.; Giovenale, E.; Mirizzi, F.; Spassovsky, I.; Ravera, G. L.; Surrenti, V.; Tuccillo, A. A.

2014-02-01

Heating and Current Drive systems are of outstanding relevance in fusion plasmas, magnetically confined in tokamak devices, as they provide the tools to reach, sustain and control burning conditions. Heating systems based on the electron cyclotron resonance (ECRH) have been extensively exploited on past and present machines DEMO, and the future reactor will require high frequencies. Therefore, high power (≥1MW) RF sources with output frequency in the 200 - 300 GHz range would be necessary. A promising source is the so called Cyclotron Auto-Resonance Maser (CARM). Preliminary results of the conceptual design of a CARM device for plasma heating, carried out at ENEA-Frascati will be presented together with the planned R&D development.

Applied research with cyclotrons

International Nuclear Information System (INIS)

Apel, P.; Dmitriev, S.; Gulbekian, G.; Gikal, B.; Ivanov, O.; Reutov, V.; Skuratov, V.

2005-01-01

During the past three decades the Flerov laboratory carried out research and development of a number of applications that have found or may find use in modern technologies. One of the applications is the so-called ion track technology enabling us to create micro- and nano-structured materials. Accelerated heavy ion beams are the unique tools for structuring insulating solids in a controllable manner. At FLNR JINR the U-400 cyclotron and the IC-100 cyclotron are employed for irradiation of materials to be modified by the track-etch technique. For practical applications, U-400 delivers the 86 Kr ion beams with total energies of 250, 350, 430 and 750 MeV, and the 136 Xe ion beams with the energy of 430 MeV. The cyclotron is equipped with a specialized channel for irradiation of polymer foils. IC-100 is a compact accelerator specially designed for the technological uses. High-intensity krypton ion beams with the energy of ∼ 1 MeV/u are available now at IC-100. Production of track-etch membranes is an example of mature technology based on irradiation with accelerated ions. The track-etch membranes offer distinct advantages over other types of membranes due to their precisely determined structure. One-pore, oligo-pore and multi-pore samples can serve as models for studying the transport of liquids, gases, particles, solutes, and electrolytes in narrow channels. Track-etch pores are also used as templates for making nano wires, nano tubes or array of nano rods. The microstructures obtained this way may find use in miniaturized devices such as sensors for biologically important molecules. Bulk and surface modification for the production of new composites and materials with special optical properties can be performed with ion beams. Flexible printed circuits, high-performance heat transfer modules, X-ray filters, and protective signs are examples of products developed in collaboration with research and industrial partners. Some recent achievements and promising ideas that

Development of baby cyclotron for PET in Korea

International Nuclear Information System (INIS)

Chai, J.S.; Kim, Y.S.; Hu, J.Y.; Shin, Y.C.; Yoon, M.H.

2001-01-01

Development of a 13 MeV cyclotron for Positron Emission Tomography (PET) has been in progress since April 1999 at the Korea Cancer Center Hospital (KCCH). The study has been carried out in a joint collaboration between KCCH and the Pohang University of Science and Technology (POSTECH). Increasing desire for an uninterrupted, reliable and timely supply of the isotopes to customers has prompted obtaining a dedicated 5-13 MeV cyclotron for PET applications and pursuing the purchase of another 30MeV medical cyclotron in the very near future. A decision has been made to design the PET cyclotron in Korea. This will not only ease the problems associated with maintenance during operation but also keep the door open for continuous upgrading of the machine in the future

A CCD camera probe for a superconducting cyclotron

International Nuclear Information System (INIS)

Marti, F.; Blue, R.; Kuchar, J.; Nolen, J.A.; Sherrill, B.; Yurkon, J.

1991-01-01

The traditional internal beam probes in cyclotrons have consisted of a differential element, a wire or thin strip, and a main probe with several fingers to determine the vertical distribution of the beam. The resolution of these probes is limited, especially in the vertical direction. The authors have developed a probe for their K1200 superconducting cyclotron based on a CCD TV camera that works in a 6 T magnetic field. The camera looks at the beam spot on a scintillating screen. The TV image is processed by a frame grabber that digitizes and displays the image in pseudocolor in real time. This probe has much better resolution than traditional probes. They can see beams with total currents as low as 0.1 pA, with position resolution of about 0.05 mm

Suppression of cyclotron instability in Electron Cyclotron Resonance ion sources by two-frequency heating

International Nuclear Information System (INIS)

Skalyga, V.; Izotov, I.; Mansfeld, D.; Kalvas, T.; Koivisto, H.; Komppula, J.; Kronholm, R.; Laulainen, J.; Tarvainen, O.

2015-01-01

Multiple frequency heating is one of the most effective techniques to improve the performance of Electron Cyclotron Resonance (ECR) ion sources. The method increases the beam current and average charge state of the extracted ions and enhances the temporal stability of the ion beams. It is demonstrated in this paper that the stabilizing effect of two-frequency heating is connected with the suppression of electron cyclotron instability. Experimental data show that the interaction between the secondary microwave radiation and the hot electron component of ECR ion source plasmas plays a crucial role in mitigation of the instabilities

Initial operation of the cyclotron CYTRACK

International Nuclear Information System (INIS)

Denisov, Yu.N.; Dolya, S.N.; Kalinichenko, V.V.; Karamysheva, G.A.; Kostromin, S.A.; Fedorenko, S.B.

2005-01-01

The industrial cyclotron CYTRACK is dedicated to produce the track membranes. It is the basic instrument for the industry of membrane products to be consumed in medicine, biotechnology, pharmacology, microelectronics and many other industries. Cyclotron CYTRACK started working in August 2002. Argon ions were accelerated to the project energy - 2.4 MeV/nucleon, the extracted beam intensity was about 200 nA, the extraction efficiency totaled ∼50%

Manufacturing on the radiopharmaceuticals produced by cyclotron

International Nuclear Information System (INIS)

Ueda, Nobuo

1994-01-01

Radiopharmaceutical (RP) produced by cyclotrons are widely used for the in vivo diagnosis of various diseases such as cancer, cerebral vascular disorders and cardiac diseases. The nuclides used as RPs and their nuclear reactions, and the quantity of RPs supplied in Japan in the last five years are shown. These RPs are delivered to about 1,100 hospitals in Japan. Thallium-201 and iodine-123 showed very high growth rate. Recently, two new I-123 RPs, BMIPP and MIBG which are heart-imaging agents, have been supplied. It suggests that the quantity of I-123 will increase much more in future. The image diagnostic method using RPs is called in vivo nuclear medicine, and has become the indispensable means for medical institutions together with X-ray CT, nuclear magnetic resonance imaging and ultrasonic diagnosis. The RPs for in vivo diagnosis generally used at present are classified into those labeled with the RIs produced with cyclotrons and those labeled with Tc-99m formed by the decay of Mo-99. The quantity being used is overwhelmingly more in the latter, but the former shows the tendency of growth. The commercial production of cyclotron RIs for medical use, the chemical forms and the diagnostic purposes of the RPs using cyclotron RIs, and the state of use of the cyclotron-produced RPs are reported. (K.I.)

Bayesian fuzzy logic-based estimation of electron cyclotron heating (ECH) power deposition in MHD control systems

Energy Technology Data Exchange (ETDEWEB)

Davoudi, Mehdi, E-mail: mehdi.davoudi@polimi.it [Department of Electrical and Computer Engineering, Buein Zahra Technical University, Buein Zahra, Qazvin (Iran, Islamic Republic of); Davoudi, Mohsen, E-mail: davoudi@eng.ikiu.ac.ir [Department of Electrical Engineering, Imam Khomeini International University, Qazvin, 34148-96818 (Iran, Islamic Republic of)

2017-06-15

Highlights: • A couple of algorithms to diagnose if Electron Cyclotron Heating (ECH) power is deposited properly on the expected deposition minor radius are proposed. • The algorithms are based on Bayesian theory and Fuzzy logic. • The algorithms are tested on the off-line experimental data acquired from Frascati Tokamak Upgrade (FTU), Frascati, Italy. • Uncertainties and evidences derived from the combination of online information formed by the measured diagnostic data and the prior information are also estimated. - Abstract: In the thermonuclear fusion systems, the new plasma control systems use some measured on-line information acquired from different sensors and prior information obtained by predictive plasma models in order to stabilize magnetic hydro dynamics (MHD) activity in a tokamak. Suppression of plasma instabilities is a key issue to improve the confinement time of controlled thermonuclear fusion with tokamaks. This paper proposes a couple of algorithms based on Bayesian theory and Fuzzy logic to diagnose if Electron Cyclotron Heating (ECH) power is deposited properly on the expected deposition minor radius (r{sub DEP}). Both algorithms also estimate uncertainties and evidences derived from the combination of the online information formed by the measured diagnostic data and the prior information. The algorithms have been employed on a set of off-line ECE channels data which have been acquired from the experimental shot number 21364 at Frascati Tokamak Upgrade (FTU), Frascati, Italy.

Electron cyclotron emission measurements during 28 GHz electron cyclotron resonance heating in Wendelstein WVII-A stellarator

International Nuclear Information System (INIS)

Hartfuss, H.J.; Gasparino, U.; Tutter, M.; Brakel, R.; Cattanei, G.; Dorst, D.; Elsner, A.; Engelhardt, K.; Erckmann, V.; Grieger, G.; Grigull, P.; Hacker, H.; Jaeckel, H.; Jaenicke, R.; Junker, J.; Kick, M.; Kroiss, H.; Kuehner, G.; Maassberg, H.; Mahn, C.; Mueller, G.; Ohlendorf, W.; Rau, F.; Renner, H.; Ringler, H.; Sardei, F.; Weller, A.; Wobig, H.; Wuersching, E.; Zippe, M.; Kasparek, W.; Mueller, G.A.; Raeuchle, E.; Schueller, P.G.; Schwoerer, K.; Thumm, M.

1987-11-01

Electron cyclotron emission measurements have been carried out on electron cyclotron resonance heated plasmas in the WENDELSTEIN VII-A Stellarator. Blackbody radiation from the thermalized plasma main body as well as radiation from a small amount of weakly relativistic suprathermal electrons has been detected. In addition sideband emission has been observed near the second harmonic of the heating line source. Harmonic generation and parametric wave decay at the upper hybrid layer may be a reasonable explanation. (orig.)

A new generation of medical cyclotrons for the 90's

International Nuclear Information System (INIS)

Milton, B.F.

1995-08-01

Cyclotrons continue to be efficient accelerators for use in radio-isotope production. In recent years, developments in accelerator technology have greatly increased the practical beam current in these machines while also improving the overall system reliability. These developments combined with the development of new isotopes for medicine and industry, and a retiring of older machines indicates a strong future for commercial cyclotrons. In this paper the authors will survey recent developments in the areas of cyclotron technology as they relate to the new generation of commercial cyclotrons. Existing and potential markets for these cyclotrons will be presented. They will also discuss the possibility of systems capable of extracted energies up to 150 MeV and extracted beam currents of up to 2.0 mA

A new generation of medical cyclotrons for the 90's

International Nuclear Information System (INIS)

Milton, B.F.

1995-08-01

Cyclotrons continue to be efficient accelerators for use in radio-isotope production. In recent years, developments in accelerator technology have greatly increased the practical beam current in these machines while also improving the overall system reliability. These developments combined with the development of new isotopes for medicine and industry, and a retiring of older machines indicates a strong future for commercial cyclotrons. In this paper we will survey recent developments in the areas of cyclotron technology as they relate to the new generation of commercial cyclotrons. Existing and potential markets for these cyclotrons will be presented. We will also discuss the possibility of systems capable of extracted energies up to 150 MeV and extracted beam currents of up to 2.0 mA. (author)

A small low energy cyclotron for radioisotope measurements

International Nuclear Information System (INIS)

Bertsche, K.J.

1989-11-01

Direct detection of 14 C by accelerator mass spectrometry has proved to be a much more sensitive method for radiocarbon dating than the decay counting method invented earlier by Libby. A small cyclotron (the ''cyclotrino'') was proposed for direct detection of radiocarbon in 1980. This combined the suppression of background through the use of negative ions, which had been used effectively in tandem accelerators, with the high intrinsic mass resolution of a cyclotron. Development of a small electrostatically-focused cyclotron for use as a mass spectrometer was previously reported but the sensitivity needed for detection of 14 C at natural abundance was not achieved. The major contributions of this work are the integration of a high current external ion source with a small flat-field, electrostatically-focused cyclotron to comprise a system capable of measuring 14 C at natural levels, and the analysis of ion motion in such a cyclotron, including a detailed analysis of phase bunching and its effect on mass resolution. A high current cesium sputter negative ion source generates a beam of carbon ions which is pre-separated with a Wien filter and is transported to the cyclotron via a series of electrostatic lenses. Beam is injected radially into the cyclotron using electrostatic deflectors and an electrostatic mirror. Axial focusing is entirely electrostatic. A microchannel plate detector is used with a phase-grated output. In its present form the system is capable of improving the sensitivity of detecting 14 C in some biomedical experiments by a factor of 10 4 . Modifications are discussed which could bring about an additional factor of 100 in sensitivity, which is important for archaeological and geological applications. Possibilities for measurements of other isotopes, such as 3 H, and 10 Be, and 26 Al, are discussed. 70 refs

ROKCY-12 (KCCH PET-dedicated cyclotron): main features and improvements

International Nuclear Information System (INIS)

Chai, J. S.; Kim, Y. S.; Yang, Y. T.; Jung, I. S.; Hong, S. S.; Lee, M. Y.; Jang, H. S.; Kim, J. H.

2002-01-01

In this paper, we describe the development of 13 MeV cyclotron (ROKCY-12) that can be used for a Position Emission Tomography(PET) purpose. This cyclotron with a maximum beam energy of 13 MeV can produce radio isotopes especially 18 F which has a relatively short half lifetime of 110 minutes. First, we show the beam characteristics can be used to carry out the operation of ROCKY-12. Based on this, a computer program has been developed to determine main cyclotron parameters such as cyclotron magnet, RF system, ion source, vacuum system and other cyclotron operation parameters. And then we show the result of design and manufacturing feature of ROKCY-12. By using this design program, one can determines magnet yoke geometry and the average magnetic fields etc. And then the three-dimensional computer program OPERA-3D has been invoked to determine magnet pole tips. Validity of the design can be seen by investigating magnetic fields, radial and vertical focusing frequencies as a function of the beam energy. In this paper, we show the results of cyclotron beam by ROCKY-12. We designed 77.3 MHz RF system and ion source system. We tested RF resonance each coupling methods. We show the result of RF design and prototype operation. Developed ion source is PIG type. We described our design methods and implementation. We report the result of getting negative hydrogen ion. Cyclotron controller asks inputs of every sensor and output of every instrument for notifying current condition to operator. It has independent controllers, for example DC power supply, vacuum system, beam profile system, beam extraction system, RF system, ion source, cooling unit and so on. Basically, each control system uses RS-485 for communication to main control computer. Consumers reward products and services that feature quality, originality, a distinct personality and charm. The International Standardization Organization (ISO) requires, as its mission, that we achieve competitive superiority by

On the origin of cyclotron lines in the spectra of X-ray pulsars

Directory of Open Access Journals (Sweden)

Mushtukov A. A.

2014-01-01

Full Text Available Cyclotron resonance scattering features are observed in the spectra of some X-ray pulsars and show significant changes in the line energy with the pulsar luminosity. In a case of bright sources, the line centroid energy is anti-correlated with the luminosity. Such a behaviour is often associated with the onset and growth of the accretion column, which is believed to be the origin of the observed emission and the cyclotron lines. However, this scenario inevitably implies large gradient of the magnetic field strength within the line-forming region, and it makes the formation of the observed line-like features problematic. Moreover, the observed variation of the cyclotron line energy is much smaller than could be anticipated for the corresponding luminosity changes. We argue that a more physically realistic situation is that the cyclotron line forms when the radiation emitted by the accretion column is reflected from the neutron star surface. The idea is based on the facts that a substantial part of column luminosity is intercepted by the neutron star surface and the reflected radiation should contain absorption features. The reflection model is developed and applied to explain the observed variations of the cyclotron line energy in a bright X-ray pulsar V 0332+53 over a wide range of luminosities.

U-2g0 cyclotron operational experience and improvement

International Nuclear Information System (INIS)

Gigal, B.N.; Gul'bekyan, G.G.; Kozlov, S.I.; Oganesyan, R.Ts.

1983-01-01

Brief description of main syste's of the U-200 isochronous 2-m cyclotron put into opera ion in 1968 is given and its operational characteristics a e presented. The cyclotron is used for conducting inve tigations in the field of nuclear physics. Ions from d uterium to argon have been accelerated in the cyclotro'. Annual time of target irradiation constitutes 2000-4000. The specific features of the cyclotron are: high l vel of a magnetic field (of about 20 kOe), possibili y of acceleration of ions with different mass-to-charge ratio a low correcting winding power, simple and high-e fective beam extraction by the method of charge exchange on a thin target allowing to vary smoothly energy of extracted ons. An experience in the U-200 cyclotron development and o eration is used as the basis for designing and choosing basic parameters of the U-200P, U-250, U-400 heavy ion cyclotrons

Electron-Cyclotron Waves

NARCIS (Netherlands)

Westerhof, E.

1994-01-01

The essential elements of the theory of electron cyclotron waves are reviewed, The two main electro-magnetic modes of propagation are identified and their dispersion and absorption properties are discussed. The importance of the use of the relativistic resonance condition is stressed.

Visual assistance system for cyclotron operation

International Nuclear Information System (INIS)

Okamura, Tetsuya; Tachikawa, Toshiki; Murakami, Tohru.

1994-01-01

A computer-based operation system for a cyclotron which assists operators has been developed. It is the operation assistance system depending on visual sense to indicate beam parameters to operators. First, the mental model of operators at the time of beam adjustment was analyzed, and it was presumed to be composed of five partial mental models, that is, beam behavior model, feasible setting region model, parameter sensitivity model, parameter interrelation model and status map model. Next, three visual interfaces were developed. Beam trajectory is rapidly calculated and graphically displayed whenever operators change parameters. Feasible setting regions (FSR) for parameters that satisfy the beam acceptance criteria of a cyclotron are indicated. The distribution of beam current values which are the quantity for evaluating adjustment is indicated as search history. Finally, for evaluating the system effectiveness, the search time required to reach the optimum conditions was measured. In addition, the system usability was evaluated by written questionnaires. The result of experiment showed the reduction of search time by about 65%. The written questionnaires survey showed the operators highly evaluate system usability. (K.I.)

Lower-hybrid absorption at the ion cyclotron harmonics

International Nuclear Information System (INIS)

Puri, S.

1975-01-01

In the presence of magnetic field gradients, the lower-hybrid wave can be absorbed through linear collisionless damping at the location of cyclotron or cyclotron harmonic resonances acting as singular turning points in the path of the advancing wave-front. (Auth.)

The essential theory of fast wave current drive with full wave method

International Nuclear Information System (INIS)

Liu Yan; Gong Xueyu; Yang Lei; Yin Chenyan; Yin Lan

2007-01-01

The full wave numerical method is developed for analyzing fast wave current drive in the range of ion cyclotron waves in tokamak plasmas, taking into account finite larmor radius effects and parallel dispersion. the physical model, the dispersion relation on the assumption of Finite Larmor Radius (FLR) effects and the form of full wave be used for computer simulation are developed. All of the work will contribute to further study of fast wave current drive. (authors)

Fabrication of beam diagnostic components for Superconducting Cyclotron at Kolkata

International Nuclear Information System (INIS)

Roy, S.; Bhattacharya, S.; Das, T.; Bhattacharyya, T.K.; Pal, S.; Pal, G.; Mallik, C.; Bhandari, R.K.

2009-01-01

The viewer probe and main probe are used for determining the position and current of charged particles as it is accelerated inside the superconducting cyclotron. The viewer probe is used to visually observe the shape of the charged particle beam inside the cyclotron with the help of a borescope. The main probe measures the distribution of charged particles. The viewer probe and main probe are bellow sealed. They can be positioned with an accuracy of 0.5 mm at different radii within the superconducting cyclotron. M9 slit is placed after the exit flange of the cyclotron. It determines the position of the beam leaving the cyclotron. The beam line has slits, faraday cup, beam viewers, collimators, etc. for beam diagnostics. This paper presents the mechanical design and details of beam diagnostic components. (author)

MC-50 AVF cyclotron operation

Energy Technology Data Exchange (ETDEWEB)

Chae, Jong Seo; Lee, Dong Hoon; Kim, You Seok; Park, Chan Won; Lee, Yong Min; Hong, Sung Seok; Lee, Min Yong

1995-12-01

The first cyclotron in Korea, MC-59 cyclotron is used for neutron irradiation, radionuclide development, production and material and biomedical research. 50.5MeV and 35MeV proton beam have been extracted with 20-70 .mu.A. A total of beam extraction time are 1095.7 hours. 206.5 hours are used for the developments and 663.8 hours are for radionuclide production and development and 225.4 hours for application researches. The shutdown days are 23days. Fundamental data for failure decrement and efficient beam extraction were composed and maintenance technologies were developed. (author). 8 tabs., 17 figs., 10 refs.

MC-50 AVF cyclotron operation

International Nuclear Information System (INIS)

Kim, Yu Seok; Chai, Jong Seo; Bak, Seong Ki; Park, Chan Won; Jo, Young Ho; Hong, Seong Seok; Lee, Min Yong; Jang Ho Ha

2000-01-01

The first cyclotron in Korea, MC-50 cyclotron is used for neutron irradiation, radionuclide development, production and material and biomedical research. 50.5MeV and 35MeV proton beam have been extracted with 20-60μA. A total of beam extraction time are 1095.7 hours. 206.5 hours are used for the developments and 663.8 hours are for radionuclide production and development and 225.4 hours for application researches. The shutdown days are 23 days. Fundamental data for failure decrement and efficient beam extraction were composed and maintenance technologies were developed

MC-50 AVF cyclotron operation

Energy Technology Data Exchange (ETDEWEB)

Kim, Yu Seok; Chai, Jong Seo; Bak, Seong Ki; Park, Chan Won; Jo, Young Ho; Hong, Seong Seok; Lee, Min Yong; Jang Ho Ha

2000-01-01

The first cyclotron in Korea, MC-50 cyclotron is used for neutron irradiation, radionuclide development, production and material and biomedical research. 50.5MeV and 35MeV proton beam have been extracted with 20-60{mu}A. A total of beam extraction time are 1095.7 hours. 206.5 hours are used for the developments and 663.8 hours are for radionuclide production and development and 225.4 hours for application researches. The shutdown days are 23 days. Fundamental data for failure decrement and efficient beam extraction were composed and maintenance technologies were developed.

MC-50 AVF cyclotron operation

International Nuclear Information System (INIS)

Chae, Jong Seo; Lee, Dong Hoon; Kim, You Seok; Park, Chan Won; Lee, Yong Min; Hong, Sung Seok; Lee, Min Yong.

1995-12-01

The first cyclotron in Korea, MC-59 cyclotron is used for neutron irradiation, radionuclide development, production and material and biomedical research. 50.5MeV and 35MeV proton beam have been extracted with 20-70 .mu.A. A total of beam extraction time are 1095.7 hours. 206.5 hours are used for the developments and 663.8 hours are for radionuclide production and development and 225.4 hours for application researches. The shutdown days are 23days. Fundamental data for failure decrement and efficient beam extraction were composed and maintenance technologies were developed. (author). 8 tabs., 17 figs., 10 refs

Radioisotope production in the I. Ph. P. E. cyclotron for medical application

Energy Technology Data Exchange (ETDEWEB)

Krasnov, N.N.; Dmitriyev, P.P.; Konjakhin, N.A.; Ognev, A.A. (Gosudarstvennyj Komitet po Ispol' zovaniyu Atomnoj Ehnergii SSSR, Obninsk. Fiziko-Ehnergeticheskij Inst.)

1982-01-01

The production methods for seven radioisotopes, Ga-67, Sr-85, Pd-103, In-111, Tm-167, Hg-197 and Pb-203, by using a classical 1.5m cyclotron in the Institute of Physics and Power Engineering, Obninsk, USSR, are described. At present, more than 50 cyclotrons in different countries are used for the production of radioisotopes applied to medicine. Radioisotopes are produced with the cyclotron in the I.Ph.P.E. in the form of irradiated targets, which are delivered to Moscow radiopharmaceutical factory, where radiopharmaceuticals are produced on the base of these targets. The cyclotron is operated in two regimes providing the acceleration of protons, deuterons and alpha -particles. Two types of target assemblies are used for irradiation, the one is intended for the internal beam, and the other is for the external beam. The reactions used for the production of seven radioisotopes described above, the types of targets, particle energy, respective irradiated materials, beam current, thick target yield and the amount of respective radioisotopes produced per year are reported. Metals have large heat conductivity, therefore the use of metal targets increases beam current, and increases the production rate of radioisotopes.

Control of alpha-particle transport by ion cyclotron resonance heating

International Nuclear Information System (INIS)

Chang, C.S.; Imre, K.; Weitzner, H.; Colestock, P.

1990-01-01

In this paper control of radial alpha-particle transport by using ion cyclotron range of frequency (ICRF) waves is investigated in a large-aspect-ratio tokamak geometry. Spatially inhomogeneous ICRF wave energy with properly selected frequencies and wave numbers can induce fast convective transports of alpha particles at the speed of order v α ∼ (P RF /n α ε 0 )ρ p , where R RF is the ICRF wave power density, n α is the alpha-particle density, ε 0 is the alpha-particle birth energy, and ρ p is the poloidal gyroradius of alpha particles at the birth energy. Application to International Thermonuclear Experimental Reactor (ITER) plasma is studied and possible antenna designs to control alpha-particle flux are discussed

Building 211 cyclotron characterization survey report

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-03-30

The Building 211 Cyclotron Characterization Survey includes an assessment of the radioactive and chemical inventory of materials stored within the facility; an evaluation of the relative distribution of accelerator-produced activation products within various cyclotron components and adjacent structures; measurement of the radiation fields throughout the facility; measurement and assessment of internal and external radioactive surface contamination on various equipment, facility structures, and air-handling systems; and an assessment of lead (Pb) paint and asbestos hazards within the facility.

Cyclotron beam dynamic simulations in MATLAB

International Nuclear Information System (INIS)

Karamysheva, G.A.; Karamyshev, O.V.; Lepkina, O.E.

2008-01-01

MATLAB is useful for beam dynamic simulations in cyclotrons. Programming in an easy-to-use environment permits creation of models in a short space of time. Advanced graphical tools of MATLAB give good visualization features to created models. The beam dynamic modeling results with an example of two different cyclotron designs are presented. Programming with MATLAB opens wide possibilities of the development of the complex program, able to perform complete block of calculations for the design of the accelerators

Amplification of radiation near cyclotron frequency due to electron population inversion

International Nuclear Information System (INIS)

Lee, L.C.; Wu, C.S.

1980-01-01

Amplification of electromagnetic waves via the cyclotron maser mechanism by a population of weakly relativistic electrons is studied. The effect of a tenuous population of low energy background plasma is included. It is found that both the ordinary and extraordinary modes can be excited by the weakly relativistic electrons with a loss-cone distribution. The growth rate for the extraordinary mode is much higher than that for the ordinary mode. Velocity spread in the energetic electron distribution function may reduce the growth rate by a factor of approximately 10 from that in the monoenergetic case. The maximum growth rate for the fast extraordinary mode (X mode) occurs near the upper hybrid cutoff frequency. Numerical results are obtained and discussed

Graphical user interface for yield and dose estimations for cyclotron-produced technetium.

Science.gov (United States)

Hou, X; Vuckovic, M; Buckley, K; Bénard, F; Schaffer, P; Ruth, T; Celler, A

2014-07-07

The cyclotron-based (100)Mo(p,2n)(99m)Tc reaction has been proposed as an alternative method for solving the shortage of (99m)Tc. With this production method, however, even if highly enriched molybdenum is used, various radioactive and stable isotopes will be produced simultaneously with (99m)Tc. In order to optimize reaction parameters and estimate potential patient doses from radiotracers labeled with cyclotron produced (99m)Tc, the yields for all reaction products must be estimated. Such calculations, however, are extremely complex and time consuming. Therefore, the objective of this study was to design a graphical user interface (GUI) that would automate these calculations, facilitate analysis of the experimental data, and predict dosimetry. The resulting GUI, named Cyclotron production Yields and Dosimetry (CYD), is based on Matlab®. It has three parts providing (a) reaction yield calculations, (b) predictions of gamma emissions and (c) dosimetry estimations. The paper presents the outline of the GUI, lists the parameters that must be provided by the user, discusses the details of calculations and provides examples of the results. Our initial experience shows that the proposed GUI allows the user to very efficiently calculate the yields of reaction products and analyze gamma spectroscopy data. However, it is expected that the main advantage of this GUI will be at the later clinical stage when entering reaction parameters will allow the user to predict production yields and estimate radiation doses to patients for each particular cyclotron run.

Magnet design and test of positron emission tomography cyclotron

International Nuclear Information System (INIS)

Wei Tao; Yang Guojun; He Xiaozhong; Pang Jian; Zhao Liangchao; Zhang Kaizhi

2012-01-01

An 11 MeV H - compact cyclotron used for medical radioactive isotope production is under construction in Institute of Fluid Physics, CAEP. The cyclotron magnet adopts the design of small valley gaps and coulee structure which can provide high average magnetic field and strong focus ability. To achieve 5 × 10 -4 measuring accuracy, a magnetic field mapping system has been developed. After iterative correction using field measurement data, the total phase excursion of the cyclotron is within ± 9° and the first harmonic is less than 10 -3 T, which are all acceptable. Furthermore, the beam testing declares the successful construction of the cyclotron magnet. Besides, some magnetic field influence factors were discussed, including the magnetic field distortion and measurement error. (authors)

Radiation safety aspects of the AGOR superconducting cyclotron facility

NARCIS (Netherlands)

Beijers, JPM; de Meijer, RJ

1996-01-01

This paper describes shielding calculations and skyshine estimates for the new AGOR K=600 superconducting cyclotron facility. Both simple, semi-empirical models and Monte-Carlo simulations were used. The calculations are based on a 200 MeV proton beam incident on a trick aluminum target. Also the

[Cyclotron based nuclear science

International Nuclear Information System (INIS)

1993-07-01

The period 1 April 1992--31 March 1993 saw the initial runs of three new spectrometers, which constitute a major portion of the new detection capabilities developed for this facility. These devices are the Proton Spectrometer (PSP) (data from which are shown on the cover of this document), the Mass Achroniat Recoil Mass Spectrometer (MARS), and the Multipole Dipole Multipole (MDM) Particle Spectrometer. The ECR-K500 cyclotron combination operated 5,849 hours. The beam was on target 39% of this time. Studies of nuclear dynamics and nuclear thermodynamics using the neutron ball have come to fruition. A critical re-evaluation of the available data on the giant monopole resonance indicated that the incompressibility is not specified to a range smaller than 200--350 MeV by those data. New systematic experiments using the MDM spectrometer are now underway. The MEGA collaboration obtained the first data on the μ → eγ decay rate and determination of the Michel parameter in normal μ decay. Experiments appear to confirm the existence of monoenergetic pair peaks even for relatively low Z projectile -- Z target combinations. Studies of the (α,2α) knockout reaction indicate that this reaction may prove to be a valuable tool for determination of reaction rates of astrophysical interest. Theoretical work reported in this document ranges from nuclear structure calculations using the IBM-2 model to calculations of kaon production and the in-medium properties of the rho and phi mesons. Nuclear dynamics and exotic shapes and fragmentation modes of hot nuclei are also addressed. New measurements of x-ray emission from highly ionized ions, of molecular dissociation and of surface interactions are reported. The research is presented in nearly 50 brief summaries usually including data and references

Studies of electron cyclotron emission on text

International Nuclear Information System (INIS)

Gandy, R.F.

1990-07-01

The Auburn University electron cyclotron emission (ECE) system has made many significant contributions to the TEXT experimental program during the past five years. Contributions include electron temperature information used in the following areas of study: electron cyclotron heating (ECH), pellet injection, and impurity/energy transport. Details of the role which the Auburn ECE system has played will now be discussed

Cyclotrons for the production of radioactive beams

International Nuclear Information System (INIS)

Clark, D.J.

1990-01-01

This paper describes the characteristics and design choices for modern cyclotrons. Cyclotrons can be used in 3 areas in the radioactive beam field: the production of high energy heavy ion beams for use in fragmentation, the spallation of targets with high energy protons, and the acceleration of radioactive beams from low energy to the MeV/u range. 16 refs., 6 figs

Wave fronts of electromagnetic cyclotron harmonic waves

International Nuclear Information System (INIS)

Ohnuma, T.; Watanabe, T.

1982-01-01

In an inhomogeneous high-density magnetized plasma, the spatial properties of the wave fronts and ray trajectories of electromagnetic ordinary and extraordinary cyclotron harmonic waves are investigated. Those waves which are radiated from a local source are found to have wave fronts which are almost parallel to the magnetic field. Also, the reflective properties of the electromagnetic cyclotron harmonic waves are confirmed

JSW's baby cyclotron

International Nuclear Information System (INIS)

Toda, Y.; Kaneda, Y.; Satoh, Y.; Suzukawa, I.; Yamada, T.

1983-01-01

Designed by The Japan Steel Works, Ltd., specially for installation in a hospital's medical department and nuclear research laboratory, '' JSW BABY CYCLOTRON '' has been developed to produce short-lived radioisotopes such as 11C, 13N, 15O and 18F. JSW's Baby Cyclotron has some design features. 1) Fixed energy and four sector azimuthally varying field. 2) Compact figure desired for hospital's nuclear medical department 3) A bitter type magnet yoke shielding activity 4) Simple control and operation 5) Easy maintenance without skilled personnel. Type BC105 (P:10MeV, d:5MeV), BC107 (P:10MeV, d:7MeV), BC168 (P:16MeV, d:8MeV) and BC1710 (P:17MeV, d:10MeV) are available according to required amount of radioisotopes. In our radioisotope production test, yield and purity of 11C, 13N, 15O and 18F are usable to clinical diagnosis

Cyclotron produced radiopharmaceuticals

International Nuclear Information System (INIS)

Kopicka, K.; Fiser, M.; Hradilek, P.; Hanc, P.; Lebeda, O.

2003-01-01

Some of the cyclotron-produced radionuclides may serve as important materials for the production of radiopharmaceuticals. This lecture deals with basic information relating to various aspects of these compounds. In comparison with radionuclides /compounds used for non-medical purposes, radiopharmaceuticals are subject to a broader scale of regulations, both from the safety and efficacy point of view; besides that, there are both radioactive and medical aspects that must be taken into account for any radiopharmaceutical. According to the regulations and in compliance with general rules of work with radioactivity, radiopharmaceuticals should only be prepared/manufactured under special conditions, using special areas and special equipment and applying special procedures (e.g. sterilisation, disinfection, aseptic work). Also, there are special procedures for cleaning and maintenance. Sometimes the requirements for the product safety clash with those for the safety of the personnel; several examples of solutions pertaining to these cases are given in the lecture. Also, the specific role of cyclotron radiopharmaceuticals is discussed. (author)

Excitation and propagation of electromagnetic fluctuations with ion-cyclotron range of frequency in magnetic reconnection laboratory experiment

International Nuclear Information System (INIS)

Inomoto, Michiaki; Tanabe, Hiroshi; Ono, Yasushi; Kuwahata, Akihiro

2013-01-01

Large-amplitude electromagnetic fluctuations of ion-cyclotron-frequency range are detected in a laboratory experiment inside the diffusion region of a magnetic reconnection with a guide field. The fluctuations have properties similar to kinetic Alfvén waves propagating obliquely to the guide field. Temporary enhancement of the reconnection rate is observed during the occurrence of the fluctuations, suggesting a relationship between the modification in the local magnetic structure given by these fluctuations and the intermittent fast magnetic reconnection

POMC and NPY mRNA expression during development is increased in rat offspring brain from mothers fed with a high fat diet.

Science.gov (United States)

Klein, Marianne Orlandini; MacKay, Harry; Edwards, Alexander; Park, Su-Bin; Kiss, Ana Carolina Inhasz; Felicio, Luciano Freitas; Abizaid, Alfonso

2018-02-01

Developmental programing is influenced by perinatal nutrition and it has long-lasting impacts on adult metabolism in the offspring. In particular, maternal high fat diet has been associated with increased risk of obesity and metabolic disorders during adulthood in the descendants. These effects may be due to the effects of the high fat diet on the development of the systems that regulate food intake and energy balance in the offspring hypothalamus. The arcuate nucleus (ARC) may be a particularly sensitive region to it as this nucleus contains the POMC and AgRP/NPY neurons that integrate the melanocortin system. Thus, the aim of this study was to investigate the effects of maternal high fat diet during pregnancy on the transcription factors that regulate hypothalamic development in the offspring as a potential mechanism that may result in altered neuronal expression of POMC, NPY and/or AgRP. To this end, pregnant females exposed to high fat diet (60% fat diet since day 0 of pregnancy) or standard rat chow were sacrificed on days 12, 14, 16 and 18 of gestation to obtain brains from their developing fetuses and examine the mRNA expression of transcription factors associated with the development of cells in the ARC. Results show that, while no changes in transcription factor expression between groups were observed, POMC and NPY mRNA expression were higher on embryonic day 18 in the high fat group. These results suggest that POMC and NPY expression are altered by in utero exposure to a high fat diet, but these changes in gene expression are not associated with changes in the expression of transcription factors known to determine the fate of ARC cells. Copyright © 2017 ISDN. Published by Elsevier Ltd. All rights reserved.

Emergency situation in a medical cyclotron facility

International Nuclear Information System (INIS)

Kumar, Rajeev; Bhat, M.K.; Singh, D.K.; Pthania, B.S.; Pandit, A.G.; Jacob, M.J.

2010-01-01

Full text: Medical cyclotron is a particle accelerator used in producing short lived radioisotopes such as 18 F, 11 C, 15 O, 13 N, 18 F-2 gas etc. Positron Emission Tomography (PET) is a nuclear imaging modality that has rapidly gained favour. 18 F-FDG is the most widely used radiopharmaceutical with a half-life of 109.8 min. Having more than five years experience in this field we face lots of emergency conditions in the medical cyclotron facility. On the basis of harm we have divided in to three categories i.e. Harm of (a) working personnel, (b) Equipment and (c) environment. Radioactive gas leak and Target foil rupture is considered as the major emergency situations during medical cyclotron operations because there is a potential of over exposure to the working personnel. Radiation protection survey of a self-shielded medical cyclotron installation was carried out during normal and emergency conditions. It is found that the induced activity in the target foil increases with its successive usages. Recommendations have also been made to reduce personal exposure while handling the radioactive gas leak and target foil rupture conditions

On Ion Cyclotron Current Drive for sawtooth control

International Nuclear Information System (INIS)

Eriksson, L.-G.; Johnson, T.; Hellsten, T.; Mayoral, M.-L.; McDonald, D.; Santala, M.; Vries, P. de; Coda, S.; Sauter, O.; Mueck, A.; Buttery, R.J.; Mantsinen, M.J.; Noterdaeme, J.-M.; Westerhof, E.

2006-01-01

Experiments using Ion Cyclotron Current Drive (ICCD) to control sawteeth are presented. In particular, discharges demonstrating shortening of fast ion induced long sawteeth reported in [L.-G. Eriksson et al., Physical Review Letters 92, 235004 (2004)] by ICCD have been analysed in detail. Numerical simulations of the ICCD driven currents are shown to be consistent with the experimental observations. They support the hypothesis that an increase of the magnetic shear, due to the driven current, at the surface where the safety factor is unity was the critical factor for the shortening of the sawteeth. In view of the potential utility of ICCD, the mechanisms for the current drive have been further investigated experimentally. This includes the influence of the averaged energy of the resonating ions carrying the current and the spectrum of the launched waves. The results of these experiments are discussed in the light of theoretical considerations. (author)

Status report on the cyclotron

International Nuclear Information System (INIS)

Kormany, Z.

2002-01-01

Complete text of publication follows. The operation of the cyclotron in 2001 was again concentrated to the usual 9 months; January, July and August were reserved for maintenance and holidays. The overall working time of the accelerator was 4300 hours, the breakdown periods amounted to 66 hours last year. The cyclotron was available for users during 3751 hours, the effectively used beam-on-target time is summarized in Table 1. The total time required for machine setup and beam tuning or spent waiting for the start of an irradiation was 272 hours. The control of the adjustable collimators applied in the beam transport system of the cyclotron was renewed during the winter maintenance period. They have been connected to the programmable logic controllers (PLC) and their new control code frees the operators from the long and slow manual setting process. The successful renewal of the control of this and other subsystems (cyclotron and beam transport power supplies) made lots of adjusting and measuring elements on the original control desk needless. To provide more space for the control PCs and remove all unnecessary devices, the unused part of the control desk has been dismantled. The short beam line used mainly for radiation hardness studies was equipped with a new oil-diffusion vacuum system during the summer maintenance. Its components are also connected to the PLC and the same automatic control has been provided like for the other vacuum stands of- the beam transport system. Another short beam line - basically a mirror image of the first one - has also been installed and successfully tested by trial irradiations. (R.P.)

RF control hardware design for CYCIAE-100 cyclotron

Energy Technology Data Exchange (ETDEWEB)

Yin, Zhiguo, E-mail: bitbearAT@hotmail.com; Fu, Xiaoliang; Ji, Bin; Zhao, Zhenlu; Zhang, Tianjue; Li, Pengzhan; Wei, Junyi; Xing, Jiansheng; Wang, Chuan

2015-11-21

The Beijing Radioactive Ion-beam Facility project is being constructed by BRIF division of China Institute of Atomic Energy. In this project, a 100 MeV high intensity compact proton cyclotron is built for multiple applications. The first successful beam extraction of CYCIAE-100 cyclotron was done in the middle of 2014. The extracted proton beam energy is 100 MeV and the beam current is more than 20 μA. The RF system of the CYCIAE-100 cyclotron includes two half-wavelength cavities, two 100 kW tetrode amplifiers and power transmission line systems (all above are independent from each other) and two sets of Low Level RF control crates. Each set of LLRF control includes an amplitude control unit, a tuning control unit, a phase control unit, a local Digital Signal Process control unit and an Advanced RISC Machines based EPICS IOC unit. These two identical LLRF control crates share one common reference clock and take advantages of modern digital technologies (e.g. DSP and Direct Digital Synthesizer) to achieve closed loop voltage and phase regulations of the dee-voltage. In the beam commission, the measured dee-voltage stability of RF system is better than 0.1% and phase stability is better than 0.03°. The hardware design of the LLRF system will be reviewed in this paper.

Statistical fluctuations in cooperative cyclotron radiation

Science.gov (United States)

Anishchenko, S. V.; Baryshevsky, V. G.

2018-01-01

Shot noise is the cause of statistical fluctuations in cooperative cyclotron radiation generated by an ensemble of electrons oscillating in magnetic field. Autophasing time - the time required for the cooperative cyclotron radiation power to peak - is the critical parameter characterizing the dynamics of electron-oscillators interacting via the radiation field. It is shown that premodulation of charged particles leads to a considerable narrowing of the autophasing time distribution function for which the analytic expression is obtained. When the number of particles Ne exceeds a certain value that depends on the degree to which the particles have been premodulated, the relative root-mean-square deviation (RMSD) of the autophasing time δT changes from a logarithmic dependence on Ne (δT ∼ 1 / lnNe) to square-root (δT ∼ 1 /√{Ne }). A slight energy spread (∼4%) results in a twofold drop of the maximum attainable power of cooperative cyclotron radiation.

Decommissioning analyzis of a university cyclotron

International Nuclear Information System (INIS)

Eggermont, G.X.; Buls, N.; Hermanne, A.

1996-01-01

In the widespread use of some medical nuclear facilities, such as cyclotrons for isotope production, Life cycle analyzis, including decommissioning, was not taken into account. The structural materials of an accelerator and the concrete shielding of the bunker are activated by neutrons. This could yield a considerable volume of nuclear waste and needs radiation protection concern for occupational workers and the environment during some decennia. At the university of Brussels (WB) a prospective radiation protection and waste analyzis is being made for the later decommissioning of their cyclotron. Only few similar studies have been published. In Belgium future nuclear dismantling operations will be submitted to a radiation protection authorization procedure. Meanwhile the nuclear waste authorities insist on dismantling planning, including financial provisioning. An optimization exercise was made at the VUB-cyclotron, taking into account international trends to clearance levels for low level nuclear waste. Conceptual prevention opportunities e.g. selective material choice could be identified for future accelerator constructions. (author)

Simulation of operation modes of isochronous cyclotron by a new interactive method

International Nuclear Information System (INIS)

Taraszkiewicz, R.; Talach, M.; Sulikowski, J.; Doruch, H.; Norys, T.; Sroka, A.; Kiyan, I.N.; )

2007-01-01

Operation mode simulation methods are based on selection of trim coil currents in the isochronous cyclotron for formation of the required magnetic field at a certain level of the main coil current. The traditional current selection method is based on finding a solution for all trim coils simultaneously. After setting the calculated operation mode, it is usually necessary to perform a control measurement of the magnetic field map and to repeat the calculation for a more accurate solution. The new current selection method is based on successively finding solutions for each particular trim coil. The trim coils are taken one by one in reverse order from the edge to the center of the isochronous cyclotron. The new operation mode simulation method is based on the new current selection method. The new method, as against the traditional one, includes iterative calculation of the kinetic energy at the extraction radius. A series of experiments on proton beam formation within the range of working acceleration radii at extraction energies from 32 to 59 MeV, which were carried out at the AIC144 multipurpose isochronous cyclotron (designed mainly for the eye melanoma treatment and production of radioisotopes) at the INP PAS (Cracow), showed that the new method makes unnecessary any control measurements of magnetic fields for getting the desired operation mode, which indicates a high accuracy of the calculation. (authors)

Comparison Between In-Beam and Offline Positron Emission Tomography Imaging of Proton and Carbon Ion Therapeutic Irradiation at Synchrotron- and Cyclotron-Based Facilities

International Nuclear Information System (INIS)

Parodi, Katia; Bortfeld, Thomas; Haberer, Thomas

2008-01-01

Purpose: The benefit of using dedicated in-beam positron emission tomography (PET) detectors in the treatment room instead of commercial tomographs nearby is an open question. This work quantitatively compares the measurable signal for in-beam and offline PET imaging, taking into account realistic acquisition strategies at different ion beam facilities. Both scenarios of pulsed and continuous irradiation from synchrotron and cyclotron accelerators are considered, because of their widespread use in most carbon ion and proton therapy centers. Methods and Materials: A mathematical framework is introduced to compare the time-dependent amount and spatial distribution of decays from irradiation-induced isotope production. The latter is calculated with Monte Carlo techniques for real proton treatments of head-and-neck and paraspinal tumors. Extrapolation to carbon ion irradiation is based on results of previous phantom experiments. Biologic clearance is modeled taking into account available data from previous animal and clinical studies. Results: Ratios between the amount of physical decays available for in-beam and offline detection range from 40% to 60% for cyclotron-based facilities, to 65% to 110% (carbon ions) and 94% to 166% (protons) at synchrotron-based facilities, and increase when including biologic clearance. Spatial distributions of decays during irradiation exhibit better correlation with the dose delivery and reduced influence of biologic processes. Conclusions: In-beam imaging can be advantageous for synchrotron-based facilities, provided that efficient PET systems enabling detection of isotope decays during beam extraction are implemented. For very short (<2 min) irradiation times at cyclotron-based facilities, a few minutes of acquisition time after the end of irradiation are needed for counting statistics, thus affecting patient throughput

Cyclotron will not survive yet this year without state support

International Nuclear Information System (INIS)

Marcan, P.

2005-01-01

In this paper the project of the Cyclotron Center of the Slovak republic is described. On the basis of this project the state joint-stock company Biont was constituted. Small cyclotron is in operation; big cyclotron is in process of manufacture and it will be put in operation in 2007. Small cyclotron will be used for production of radiopharmaceuticals. Positron emission tomograph (PET) in Oncological Institute of St. Elizabeth (in Bratislava) and gamma camera in Central Military Hospital (in Ruzomberok) are constituents of the Biont. The PET will be also in Biont. The hadron therapy of ophthalmic tumors is planned. Financial plans of the Biont up to 2009 are presented

The problems of high efficient extraction from the isochronous cyclotron

International Nuclear Information System (INIS)

Schwabe, J.

1994-06-01

The problem of high efficient extraction (η ≥ 50%) from isochronous cyclotrons (with the exception of the stripping method) is not completely solved up to this day. This problem is specifically important, because these cyclotrons are being also applied in the production of medical radioisotopes, labeled pharmaceuticals as well as in neutron therapy (oncology), machine industry, agriculture (plant mutagenesis), etc. The aim of the proposed topic is to solve this problem on the AIC-144 isochronous cyclotron in the INP (Institute of Nuclear Physics). Lately, a beam of 20 MeV deuterons with an efficiency of ca. 15% was extracted from this cyclotron. (author). 25 refs, 14 figs

The local distribution of radiation quality of a collimated fast neutron beam from 15 MeV deuterons on beryllium

International Nuclear Information System (INIS)

Fidorra, J.; Booz, J.

1978-01-01

The local distribution of radiation quality (ysub(F), ysub(D)) of a collimated fast neutron beam from 14 MeV deuterons on Beryllium was studied with a spherical 1/2 inch EG and G proportional counter simulating a diameter of 2μm. The deuterons were accelerated by the compact cyclotron CV-28 of the Kernforschungsanlage Juelich. The collimator was constructed by the Cyclotron Corporation. The mean neutron energy was 6 MeV. The measurements were performed in air and in a water phantom at a target skin distance of 125 cm. The energy deposition spectra of fast neutrons obtained at various positions were separated into three components of different radiation quality: the gamma component, the recoil proton component, and the heavy ion component

Ion cyclotron emission in tokamak plasmas; Emission cyclotronique ionique dans les plasmas de tokamak

Energy Technology Data Exchange (ETDEWEB)

Fraboulet, D.

1996-09-17

Detection of {alpha}(3.5 MeV) fusion products will be of major importance for the achievement of self sustained discharges in fusion thermonuclear reactors. Due to their cyclotronic gyration in the confining magnetic field of a tokamak, {alpha} particles are suspected to radiate in the radio-frequency band [RF: 10-500 MHz]. Our aim is to determine whether detection of RF emission radiated from a reactor plasma can provide information concerning those fusion products. We observed experimentally that the RF emission radiated from fast ions situated in the core of the discharge is detectable with a probe located at the plasma edge. For that purpose, fast temporal acquisition of spectral power was achieved in a narrow frequency band. We also propose two complementary models for this emission. In the first one, we describe locally the energy transfer between the photon population and the plasma and we compute the radiation equilibrium taking place in the tokamak. {alpha} particles are not the unique species involved in the equilibrium and it is necessary to take into account all other species present in the plasma (Deuterium, Tritium, electrons,...). Our second model consists in the numerical resolution of the Maxwell-Vlasov with the use of a variational formulation, in which all polarizations are considered and the 4 first cyclotronic harmonics are included in a 1-D slab geometry. The development of this second model leads to the proposal for an experimental set up aiming to the feasibility demonstration of a routine diagnostic providing the central {alpha} density in a reactor. (author). 166 refs.

Cyclotron Production of Technetium-99m

Science.gov (United States)

Gagnon, Katherine M.

-produced 99mTc has been extensively compared with relevant United States Pharmacopeia (USP) specifications for the existing 99Mo/99mTc production strategy. Additional quality testing, including biodistribution studies of [ 99mTc]pertechnetate and [99mTc]disofenin in both mice and rabbits was also evaluated. Using the strategies and results presented throughout this dissertation, this thesis concludes with the world's first cyclotron-based 99mTc patient images obtained as part of a Phase I Clinical Trial at the University of Alberta using [99m Tc]pertechnetate.

Fast neutron dosimeter with wide base silicon diode

International Nuclear Information System (INIS)

Ma Lu

1986-01-01

This paper briefly introduces a wide base silicon diode fast neutron dosimeter with wide measuring range and good energy response to fast neutron. It is suitable to be used to detect fast neutrons in the mixed field of γ-ray, thermal neutrons and fast neutrons

Thermal Stabilization of Cryogenic System in Superconducting Cyclotron

International Nuclear Information System (INIS)

Shin, Seung Jae; Kim, Kyung Min; Cho, Hyung Hee; Hong, Bong Hwan; Kang, Joon Sun; Ahn, Dong Hyun

2011-01-01

Radiology has some useful applications for medical purpose. For cancer therapy, the superconducting cyclotron should generate heavy ion beams. It radiates heavy ion beams to cancer patients. In order to make cyclotron system stable, the cryogenic system which makes superconducting state should work constantly. However, radiation heat transfer of cryogenic system should be considered because liquid helium's boiling point is extremely low and there is huge temperature difference between the cryogenic system and ambient temperature. Accordingly, thermal analysis should be carried out. In this paper, the numerical analysis of the cryogenic system in practical superconducting cyclotron show temperature distribution and suggest the number of coolers using ANSYS Workbench program

The Cyclotron Center of the Slovak Republic

International Nuclear Information System (INIS)

Podhorsky, D.; Ruzicka, J.; Macasek, F.; Makaiova, I.; Saro, S.; Kristiak, J.; Fulup, M.

2001-01-01

The Cyclotron Center of the Slovak Republic was established at the beginning of August 1999 - within the Slovak-Office of Standards, Metrology and Testing (SOSMT), in Bratislava, Slovak Republic. It will have two cyclotrons - a large heavy and light cyclotron DC-72, which will be constructed by the Joint Institute for Nuclear Research (JINR), Dubna, Russian Federation, and a small commercial light ion cyclotron IBA 18/9. The heavy ion source of the electron resonance type (DECRS-2M) will be used for low and medium energy experiments in physics. The small electron accelerator is planned for different applications, including improving the properties of plastics, increasing the resistance of cables to fire and temperature, the sterilization of medical disposables in the CC SR. The main purpose of the Cyclotron Center of the Slovak Republic (CC SR) is to catch the present approach and trends in the area of improving of inhabitants life and health quality using the progressive technology, which is introduced by bringing into practice of the physical equipment - accelerators, producing beams of high energy particles. Experts of nuclear physics and of the related branches have no experimental basis in Slovakia, as after dissolution of the former the Czech and Slovak Federal Republic all bigger nuclear equipment were left in the Czech Republic. The Slovak Republic is one of the European countries where cancer and cardiovascular diseases have a rapidly increasing tendency (the rate of new oncological cases is approximately 20,000/year at the population of 5 million inhabitants) - early diagnostics of population is necessary to be updated urgently. The Slovak Republic use a great part of electricity (about 60 %) from its own nuclear power stations and thus it is in need of education of rising generations of experts from different nuclear fields. The Government of the Slovak republic on June 18, 1996 approved the strategic aim of building up the Cyclotron Laboratory at the

A radioisotope production cyclotron designed to minimize dose

International Nuclear Information System (INIS)

Szlavik, F.F.; Moritz, L.E.

1992-01-01

This paper describes a radioisotope production cyclotron which has been designed to minimize the dose to personnel during operation and maintenance. The design incorporates lessons learned from the operation of a CP42 cyclotron and has resulted in a reduction of the dose by a factor of more than 10. (author)

Geometric analysis of phase bunching in the central region of cyclotron

International Nuclear Information System (INIS)

Miyawaki, Nobumasa; Fukuda, Mitsuhiro; Kurashima, Satoshi; Kashiwagi, Hirotsugu; Okumura, Susumu; Arakawa, Kazuo; Kamiya, Tomihiro

2013-01-01

An optimum condition for realizing phase bunching in the central region of a cyclotron was quantitatively clarified by a simplified geometric trajectory analysis of charged particles from the first to the second acceleration gap. The phase bunching performance was evaluated for a general case of a cyclotron. The phase difference of incident particles at the second acceleration gap depends on the combination of four parameters: the acceleration harmonic number h, the span angle θ D of the dee electrode, the span angle θ F from the first to the second acceleration gap, the ratio R V of the peak acceleration voltage between the cyclotron and ion source. Optimum values of θ F for phase bunching were limited by the relationship between h and θ D , which is 90°/h+θ D /2≤θ F ≤180°/h+θ D /2, and sin θ F >0. The phase difference with respect to the reference particle at the second acceleration gap is minimized for voltage-ratios between two and four for an initial phase difference within 40 RF degrees. Although the slope of the first acceleration gap contributes to the RF phase at which the particles reach the second acceleration gap, phase bunching was not affected. An orbit simulation of the AVF cyclotron at the Japan Atomic Energy Agency verifies the evaluation based on geometric analysis

Electromagnetic Ion Cyclotron Waves in the Helium Branch Induced by Multiple Electromagnetic Ion Cyclotron Triggered Emissions

Science.gov (United States)

Shoji, M.; Omura, Y.; Grison, B.; Pickett, J. S.; Dandouras, I. S.; Engebretson, M. J.

2011-12-01

Electromagnetic ion cyclotron (EMIC) triggered emissions with rising tones between the H+ and He+ cyclotron frequencies were found in the inner magnetosphere by the recent Cluster observations. Another type of EMIC wave with a constant frequency is occasionally observed below the He+ cyclotron frequency after the multiple EMIC triggered emissions. We performed a self-consistent hybrid simulation with a one-dimensional cylindrical magnetic flux model approximating the dipole magnetic field of the Earth's inner magnetosphere. In the presence of energetic protons with a sufficient density and temperature anisotropy, multiple EMIC triggered emissions are reproduced due to the nonlinear wave growth mechanism of rising-tone chorus emissions, and a constant frequency wave in the He+ EMIC branch is subsequently generated. Through interaction with the multiple EMIC rising-tone emissions, the velocity distribution function of the energetic protons is strongly modified. Because of the pitch angle scattering of the protons, the gradient of the distribution in velocity phase space is enhanced along the diffusion curve of the He+ branch wave, resulting in the linear growth of the EMIC wave in the He+ branch.

Properties of the TRIUMF cyclotron beam

International Nuclear Information System (INIS)

Craddock, M.K.; Blackmore, E.W.; Dutto, G.; Kost, C.J.; Mackenzie, G.H.; Richardson, J.R.; Root, L.W.; Schmor, P.

1975-08-01

Eight percent of the 300 keV d.c. beam from the ion source can be transmitted to 500 MeV in the TRIUMF cyclotron, without using the buncher. The beam losses are entirely accounted for; there are no significant losses due to orbit dynamic problems during 1500 turns of acceleration. The phase history is in good agreement with predictions based on the magnetic field survey. The effect of the harmonic coils and injection parameters on beam quality has been investigated. (author)

Characterization of fast pyrolysis products generated from several western USA woody species

Science.gov (United States)

Jacqueline M. Jarvis; Deborah S. Page-Dumroese; Nathaniel M. Anderson; Yuri Corilo; Ryan P. Rodgers

2014-01-01

Woody biomass has the potential to be utilized at an alternative fuel source through its pyrolytic conversion. Here, fast pyrolysis bio-oils derived from several western USA woody species are characterized by negative-ion electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI FT-ICR MS) to determine molecular-level composition. The...

Involvement of CD36 in Modulating the Decrease of NPY and AgRP Induced by Acute Palmitic Acid Stimulation in N1E-115 Cells

Directory of Open Access Journals (Sweden)

Yan Ma

2017-06-01

Full Text Available Central nervous system (CNS fatty acid sensing plays an important role in the regulation of food intake, and palmitic acid (PA is the most important long chain fatty acid (LCFA in the mammalian diet. To explore the effect of PA on central neuropeptide expression and the role of the cluster of the differentiation of 36 (CD36 in the process, N1E-115 cells were cultured with PA in the presence or absence of sulfosuccinimidyl-oleate (SSO, a CD36 inhibitor. Results showed that 10 μmol/L PA significantly reduced NPY and AgRP mRNA expression after 20 min of exposure, while the expression of CD36 was upregulated. The presence of SSO significantly attenuated the decrease of NPY and AgRP expression that was induced by PA alone, although no notable effect on PA- induced CD36 gene expression was observed. In conclusion, our study suggests the involvement of CD36 in the PA-induced decrease of NPY and AgRP in N1E-115 cells.

Conceptual design of the RF accelerating cavities for a superconducting cyclotron

International Nuclear Information System (INIS)

Maggiore, M.; Calabretta, L.; Di Giacomo, M.; Rifuggiato, D.; Battaglia, D.; Piazza, L.

2006-01-01

A superconducting cyclotron accelerating ions up to 250 A MeV, for medical applications and radioactive ions production is being studied at Laboratori Nazionali del Sud in Catania. The radio frequency (RF) system, working in the fourth harmonic, is based on four normal conducting radio frequency cavities operating at 93 MHz. This paper describes an unusual multi-stem cavity design, performed with 3D electromagnetic codes. Our aim is to obtain a cavity, completely housed inside the cyclotron, with a voltage distribution ranging from 65 kV in the injection region to a peak value of 120 kV in the extraction region, and having a low power consumption

Radiation protection problems by the operation of the cyclotron facility

International Nuclear Information System (INIS)

Durcik, M.; Nikodemova, D.

1998-01-01

The Cyclotron Center in Bratislava will consist of two cyclotrons. First - cyclotron DC-72 with maximal energy of 72 MV for protons for making experiments, for teaching process, for radioisotope production as 123 I and for neutron and proton therapy. Second - compact cyclotron with maximal proton energy of 18 MeV will be used for radioisotopes production for medical diagnosis as 1 *F (fluorodeoxyglucose), 81 Rb/ 81 Kr generator. This paper deals with the radiation protection problems by the operation of tis cyclotron facility as radiation protection of workers, monitoring plan, ventilation, safety lock and limitation and radiation monitoring. For proposed and continuing practices at the accelerator facility, the following general principles have to be fulfilled: (1) practices should produce sufficient benefit to offset the radiation detriment they case (justification); (2) the magnitude of the individual doses should be kept as low as achievable (optimization of protection); (3) individual exposures are subject to dose limits and some control of risk from potential exposures (dose and risk limits)

A 30 MeV H- cyclotron for isotope production

International Nuclear Information System (INIS)

Milton, B.F.; Dawson, R.; Erdman, K.L.

1989-05-01

Because of an expanding market for radioisotopes there is a need for a new generation of cyclotrons designed specifically for this purpose. TRIUMF is cooperating with a local industrial company in designing and constructing such a cyclotron. It will be a four sector H - cyclotron, exploiting the newly developed high brightness multicusp ion source. This source with H - current capability in excess of 5 mA makes feasible accelerated H - beam intensities of up to 500 μA. Beam extraction is by stripping to H + in a thin graphite foil. Extraction of two high-intensity beams, with energy variable from 15 to 30 MeV is planned. The use of an external ion source, provision of a good vacuum in the acceleration region, and the careful choice of materials for components in the median plane leads to a cyclotron that will have low activation and can be easily serviced in spite of the very high operating beam intensities. A design extension to 70 MeV using many of the design features of the 30 MeV cyclotron can be easily made. Such a machine with a good quality variable energy beam is a highly desirable source of protons for isotope production, injection into higher energy high intensity acceleration, injection into higher energy high intensity accelerators, and as an irradiation facility for ocular melanomas. Design of the 30 MeV cyclotron is well advanced and construction is in progress

Ion-Beam-Excited Electrostatic Ion Cyclotron Waves

DEFF Research Database (Denmark)

Michelsen, Poul; Pécseli, Hans; Juul Rasmussen, Jens

1976-01-01

Self-excited electrostatic ion cyclotron waves were observed in an ion-beam-plasma system produced in a DP-operated Q-machine. The frequency of the waves showed the theoretically predicted variation with the magnetic field.......Self-excited electrostatic ion cyclotron waves were observed in an ion-beam-plasma system produced in a DP-operated Q-machine. The frequency of the waves showed the theoretically predicted variation with the magnetic field....

Calculation of particle dynamics in CI-10 cyclotron

International Nuclear Information System (INIS)

Samsonov, E.V.; Karamysheva, G.A.; Vorozhtsov, S.B.

1999-01-01

The calculations of beam dynamic characteristics of High-Intensity Cyclotron-Injector CI-10 for deuteron beam of 15 MeV energy are presented. Analytical estimations of space charge effects are given. In order to increase the intensity of the accelerator beam some ideas about the cyclotron design modification are given too. (author)

Design of RF system for CYCIAE-230 superconducting cyclotron

Energy Technology Data Exchange (ETDEWEB)

Yin, Zhiguo, E-mail: bitbearAT@hotmail.com; Ji, Bin; Fu, Xiaoliang; Cao, Xuelong; Zhao, Zhenlu; Zhang, Tinajue

2017-05-11

The CYCIAE230 is a low-current, compact superconducting cyclotron designed for proton therapy. The Radio Frequency system consists of four RF cavities and applies second harmonic to accelerate beams. The driving power for the cavity system is estimated to be approximately 150 kW. The LLRF controller is a self-made device developed and tested at low power using a small-scale cavity model. In this paper, the resonator systems of an S.C. cyclotron in history are reviewed. Contrary to those RF systems, the cavities of the CYCIAE230 cyclotron connect two opposite dees. Two high-power RF windows are included in the system. Each window carries approximately 75 kW RF power from the driver to the cavities. Thus, the RF system for the CY-CIAE230 cyclotron is operated in driven push–pull mode. The two-way amplifier-coupler-cavity systems are operated with approximately the same amount of RF power but 180° out of phase compared with each other. The design, as well as the technical advantage and limitations of this operating mode, of the CYCIAE230 cyclotron RF system is analyzed.

Design of RF system for CYCIAE-230 superconducting cyclotron

Science.gov (United States)

Yin, Zhiguo; Ji, Bin; Fu, Xiaoliang; Cao, Xuelong; Zhao, Zhenlu; Zhang, Tinajue

2017-05-01

The CYCIAE230 is a low-current, compact superconducting cyclotron designed for proton therapy. The Radio Frequency system consists of four RF cavities and applies second harmonic to accelerate beams. The driving power for the cavity system is estimated to be approximately 150 kW. The LLRF controller is a self-made device developed and tested at low power using a small-scale cavity model. In this paper, the resonator systems of an S.C. cyclotron in history are reviewed. Contrary to those RF systems, the cavities of the CYCIAE230 cyclotron connect two opposite dees. Two high-power RF windows are included in the system. Each window carries approximately 75 kW RF power from the driver to the cavities. Thus, the RF system for the CY-CIAE230 cyclotron is operated in driven push-pull mode. The two-way amplifier-coupler-cavity systems are operated with approximately the same amount of RF power but 180° out of phase compared with each other. The design, as well as the technical advantage and limitations of this operating mode, of the CYCIAE230 cyclotron RF system is analyzed.

Topological model of composite fermions in the cyclotron band generator picture: New insights

Science.gov (United States)

Staśkiewicz, Beata

2018-03-01

A combinatorial group theory in the braid groups is correlated with the unusual "anyon" statistic of particles in 2D Hall system in the fractional quantum regime well. On this background has been derived cyclotron band generator as a modification and generalization band generator, first established to solve the word and conjugacy problems in the braid group terms. Topological commensurability condition has been embraced by canonical factors - like, based on the concept of parallel descending cycles. Owing to this we can mathematically capture the general hierarchy of correlated states in the lowest Landau level, describing the fractional quantum Hall effect hierarchy, in terms of cyclotron band generators, especially for those being beyond conventional composite fermions model. It has been also shown that cyclotron braid subgroups, developed for interpretation of Laughlin correlations, are a special case of the right-angled Artin groups.

Proceedings of eighth joint workshop on electron cyclotron emission and electron cyclotron resonance heating. Vol. 1

International Nuclear Information System (INIS)

1993-03-01

The theory of electron cyclotron resonance phenomena is highly developed. The main theoretical tools are well established, generally accepted and able to give a satisfactory description of the main results obtained in electron cyclotron emission, absorption and current drive experiments. In this workshop some advanced theoretical and numerical tools have been presented (e.g., 3-D Fokker-Planck codes, treatment of the r.f. beam as a whole, description of non-linear and finite-beam effects) together with the proposal for new scenarios for ECE and ECA measurements (e.g., for diagnosing suprathermal populations and their radial transport). (orig.)

Proceedings of eighth joint workshop on electron cyclotron emission and electron cyclotron resonance heating. Vol. 2

International Nuclear Information System (INIS)

1993-03-01

The theory of electron cyclotron resonance phenomena is highly developed. The main theoretical tools are well established, generally accepted and able to give a satisfactory description of the main results obtained in electron cyclotron emission, absorption and current drive experiments. In this workshop some advanced theoretical and numerical tools have been presented (e.g., 3-D Fokker-Planck codes, treatment of the r.f. beam as a whole, description of non-linear and finite-beam effects) together with the proposal for new scenarios for ECE and ECA measurements (e.g., for diagnosing suprathermal populations and their radial transport). (orig.)

Central nervous system neuropeptide Y regulates mediators of hepatic phospholipid remodeling and very low-density lipoprotein triglyceride secretion via sympathetic innervation

Science.gov (United States)

Rojas, Jennifer M.; Bruinstroop, Eveline; Printz, Richard L.; Alijagic-Boers, Aldijana; Foppen, Ewout; Turney, Maxine K.; George, Leena; Beck-Sickinger, Annette G.; Kalsbeek, Andries; Niswender, Kevin D.

2015-01-01

Objective Elevated very low-density lipoprotein (VLDL)-triglyceride (TG) secretion from the liver contributes to an atherogenic dyslipidemia that is associated with obesity, diabetes and the metabolic syndrome. Numerous models of obesity and diabetes are characterized by increased central nervous system (CNS) neuropeptide Y (NPY); in fact, a single intracerebroventricular (icv) administration of NPY in lean fasted rats elevates hepatic VLDL-TG secretion and does so, in large part, via signaling through the CNS NPY Y1 receptor. Thus, our overarching hypothesis is that elevated CNS NPY action contributes to dyslipidemia by activating central circuits that modulate liver lipid metabolism. Methods Chow-fed Zucker fatty (ZF) rats were pair-fed by matching their caloric intake to that of lean controls and effects on body weight, plasma TG, and liver content of TG and phospholipid (PL) were compared to ad-libitum (ad-lib) fed ZF rats. Additionally, lean 4-h fasted rats with intact or disrupted hepatic sympathetic innervation were treated with icv NPY or NPY Y1 receptor agonist to identify novel hepatic mechanisms by which NPY promotes VLDL particle maturation and secretion. Results Manipulation of plasma TG levels in obese ZF rats, through pair-feeding had no effect on liver TG content; however, hepatic PL content was substantially reduced and was tightly correlated with plasma TG levels. Treatment with icv NPY or a selective NPY Y1 receptor agonist in lean fasted rats robustly activated key hepatic regulatory proteins, stearoyl-CoA desaturase-1 (SCD-1), ADP-ribosylation factor-1 (ARF-1), and lipin-1, known to be involved in remodeling liver PL into TG for VLDL maturation and secretion. Lastly, we show that the effects of CNS NPY on key liporegulatory proteins are attenuated by hepatic sympathetic denervation. Conclusions These data support a model in which CNS NPY modulates mediators of hepatic PL remodeling and VLDL maturation to stimulate VLDL-TG secretion that is

Calculation of proton beam initial orbit at cyclotron central region

International Nuclear Information System (INIS)

Pramudita Anggraita

2012-01-01

A calculation of proton beam initial orbits at cyclotron central region was carried out using Scilab 5.2.0. The calculation was done in 2 dimensions in a homogeneous magnetic field of 1.66 tesla at frequency of fourth harmonics. The positions of ion source, dees, and dummy dees follow those of GE Minitrace cyclotron, peak dee voltage 30 kV. The calculation yields result comparable to those simulated at KIRAMS-13 cyclotron. (author)

Cyclotron resonant scattering feature simulations. II. Description of the CRSF simulation process

Science.gov (United States)

Schwarm, F.-W.; Ballhausen, R.; Falkner, S.; Schönherr, G.; Pottschmidt, K.; Wolff, M. T.; Becker, P. A.; Fürst, F.; Marcu-Cheatham, D. M.; Hemphill, P. B.; Sokolova-Lapa, E.; Dauser, T.; Klochkov, D.; Ferrigno, C.; Wilms, J.

2017-05-01

Context. Cyclotron resonant scattering features (CRSFs) are formed by scattering of X-ray photons off quantized plasma electrons in the strong magnetic field (of the order 1012 G) close to the surface of an accreting X-ray pulsar. Due to the complex scattering cross-sections, the line profiles of CRSFs cannot be described by an analytic expression. Numerical methods, such as Monte Carlo (MC) simulations of the scattering processes, are required in order to predict precise line shapes for a given physical setup, which can be compared to observations to gain information about the underlying physics in these systems. Aims: A versatile simulation code is needed for the generation of synthetic cyclotron lines. Sophisticated geometries should be investigatable by making their simulation possible for the first time. Methods: The simulation utilizes the mean free path tables described in the first paper of this series for the fast interpolation of propagation lengths. The code is parallelized to make the very time-consuming simulations possible on convenient time scales. Furthermore, it can generate responses to monoenergetic photon injections, producing Green's functions, which can be used later to generate spectra for arbitrary continua. Results: We develop a new simulation code to generate synthetic cyclotron lines for complex scenarios, allowing for unprecedented physical interpretation of the observed data. An associated XSPEC model implementation is used to fit synthetic line profiles to NuSTAR data of Cep X-4. The code has been developed with the main goal of overcoming previous geometrical constraints in MC simulations of CRSFs. By applying this code also to more simple, classic geometries used in previous works, we furthermore address issues of code verification and cross-comparison of various models. The XSPEC model and the Green's function tables are available online (see link in footnote, page 1).

Monitoring of the current profile by using cyclotronic electron waves in tokamaks; Controle du profil de courant par ondes cyclotroniques electroniques dans les tokamaks

Energy Technology Data Exchange (ETDEWEB)

Dumont, R

2001-08-01

The subject of this thesis is the study of the cyclotronic electron wave as a monitoring tool of the current profile. The first chapter is dedicated to basic notions concerning tokamak plasmas and current generation. The second chapter is centered on the use of fast electrons to generate current and on its modelling. The propagation and absorption of the cyclotronic electron wave require a specific polarization state whose characteristics must be carefully chosen according to some parameters of the discharge, the chapter 3 deals with this topic. The absorption of a wave in a plasma depends greatly on the velocity distribution of the particles that make up the plasma and this distribution is constantly modified by the energy of the wave, so this phenomenon is non-linear and its physical description is difficult. In a case of a fusion plasma, a sophisticated approximation called quasi-linear theory can be applied with some restrictions that are presented in chapter 4. Chapters 5 and 6 are dedicated to kinetics scenarios involving the low hybrid wave and the cyclotronic electron wave inside the plasma. Some experiments dedicated to the study of the cyclotronic electron wave have been performed in Tore-supra (France) and FTU (Italy) tokamaks, they are presented in the last chapter. (A.C.)

The development of cyclotron radiopharmaceuticals

Energy Technology Data Exchange (ETDEWEB)

Yang, Seung Dae; Chun, K. W.; Suh, Y. S.; Lee, J. D.; Ahn, S. H. and others

1999-03-01

The purpose of this project is to developthe radiopharmaceuticals and automatic synthetic unit for labelled compounds, and to establish mass production system of radiopharmaceuticals. These will contribute to the early diagnosis of the disease hard to cure. The contents of this project are as follows, the development of the radiopharmaceutical for imaging of cancer, the development of automatic synthesizer for the synthesis of radio-pharmaceuticals, the development of hormone derivatives labelled with {sup 12}'3I, the development of the radiopharmaceuticals for therapy of cancer labelled with cyclotron produced radionuclides, the development of radiopharmaceuticals for therapy of cancer labelled with cyclotron produced radionuclides, the development of radiopharmaceuticals for imaging of myocardial metabolism.

The development of cyclotron radiopharmaceuticals

International Nuclear Information System (INIS)

Yang, Seung Dae; Chun, K. W.; Suh, Y. S.; Lee, J. D.; Ahn, S. H. and others

1999-03-01

The purpose of this project is to develop the radiopharmaceuticals and automatic synthetic unit for labelled compounds, and to establish mass production system of radiopharmaceuticals. These will contribute to the early diagnosis of the disease hard to cure. The contents of this project are as follows, the development of the radiopharmaceutical for imaging of cancer, the development of automatic synthesizer for the synthesis of radio-pharmaceuticals, the development of hormone derivatives labelled with 12 '3I, the development of the radiopharmaceuticals for therapy of cancer labelled with cyclotron produced radionuclides, the development of radiopharmaceuticals for therapy of cancer labelled with cyclotron produced radionuclides, the development of radiopharmaceuticals for imaging of myocardial metabolism

Aberrant methylation of NPY, PENK, and WIF1 as a promising marker for blood-based diagnosis of colorectal cancer

KAUST Repository

Roperch, J.-P.; Incitti, R.; Forbin, S.; Bard, F.; Mansour, H.; Mesli, F.; Baumgaertner, I.; Brunetti, F.; Sobhani, I.

2013-01-01

Background: DNA methylation is a well-known epigenetic mechanism involved in epigenetic gene regulation. Several genes were reported hypermethylated in CRC, althought no gene marker was proven to be individually of sufficient sensitivity or specificity in routine clinical practice. Here, we identified novel epigenetic markers and assessed their combined use for diagnostic accuracy.Methods: We used methylation arrays on samples from several effluents to characterize methylation profiles in CRC samples and controls, as established by colonoscopy and pathology findings, and selected two differentially methylated candidate epigenetic genes (NPY, PENK). To this gene panel we added WIF, on the basis of being reported in literature as silenced by promoter hypermethylation in several cancers, including CRC. We measured their methylation degrees by quantitative multiplex-methylation specific PCR (QM-MSP) on 15 paired carcinomas and adjacent non-cancerous colorectal tissues and we subsequently performed a clinical validation on two different series of 266 serums, subdivided in 32 CRC, 26 polyps, 47 other cancers and 161 with normal colonoscopy. We assessed the results by receiver operating characteristic curve (ROC), using cumulative methylation index (CMI) as variable threshold.Results: We obtained CRC detection on tissues with both sensitivity and specificity of 100%. On serum CRC samples, we obtained sensitivity/specificity values of, e.g., 87%/80%, 78%/90% and 59%/95%, and negative predictive value/positive predictive value figures of 97%/47%, 95%/61% and 92%/70%. On serum samples from other cancers we obtained sensitivity/specificity of, e.g, 89%/25%, 43%/80% and 28%/91%.Conclusions: We showed the potential of NPY, PENK, and WIF1 as combined epigenetic markers for CRC diagnosis, both in tissue and serum and tested their use as serum biomarkers in other cancers. We optimized a QM-MSP for simultaneously quantifying their methylation levels. Our assay can be an effective

Aberrant methylation of NPY, PENK, and WIF1 as a promising marker for blood-based diagnosis of colorectal cancer

KAUST Repository

Roperch, J.-P.

2013-12-01

Background: DNA methylation is a well-known epigenetic mechanism involved in epigenetic gene regulation. Several genes were reported hypermethylated in CRC, althought no gene marker was proven to be individually of sufficient sensitivity or specificity in routine clinical practice. Here, we identified novel epigenetic markers and assessed their combined use for diagnostic accuracy.Methods: We used methylation arrays on samples from several effluents to characterize methylation profiles in CRC samples and controls, as established by colonoscopy and pathology findings, and selected two differentially methylated candidate epigenetic genes (NPY, PENK). To this gene panel we added WIF, on the basis of being reported in literature as silenced by promoter hypermethylation in several cancers, including CRC. We measured their methylation degrees by quantitative multiplex-methylation specific PCR (QM-MSP) on 15 paired carcinomas and adjacent non-cancerous colorectal tissues and we subsequently performed a clinical validation on two different series of 266 serums, subdivided in 32 CRC, 26 polyps, 47 other cancers and 161 with normal colonoscopy. We assessed the results by receiver operating characteristic curve (ROC), using cumulative methylation index (CMI) as variable threshold.Results: We obtained CRC detection on tissues with both sensitivity and specificity of 100%. On serum CRC samples, we obtained sensitivity/specificity values of, e.g., 87%/80%, 78%/90% and 59%/95%, and negative predictive value/positive predictive value figures of 97%/47%, 95%/61% and 92%/70%. On serum samples from other cancers we obtained sensitivity/specificity of, e.g, 89%/25%, 43%/80% and 28%/91%.Conclusions: We showed the potential of NPY, PENK, and WIF1 as combined epigenetic markers for CRC diagnosis, both in tissue and serum and tested their use as serum biomarkers in other cancers. We optimized a QM-MSP for simultaneously quantifying their methylation levels. Our assay can be an effective

On the acceleration of alpha particles in the fast solar wind

International Nuclear Information System (INIS)

Gomberoff, L.; Hernandez, R.

1992-01-01

Recently, Gomberoff and Elgueta (1991) showed that in a plasma composed of anisotropic protons and alpha particles drifting along an external magnetic field with a small velocity relative to the protons, strong left-hand polarized electromagnetic ion cyclotron waves can be generated. These waves can accelerate the alpha particles to velocities well in excess of the proton bulk velocity. Here the authors assume a more realistic model of the solar wind by considering a double-humped proton distribution. It is shown that the secondary proton beam has no important effects on the ion cyclotron waves for beam densities of the order of those observed in fast solar wind conditions. The fact that the alpha proton drift velocity is modulated by the Alfven velocity remains unexplained

Relationship Between the Parameters of the Linear and Nonlinear Wave Generation Stages in a Magnetospheric Cyclotron Maser in the Backward-Wave Oscillator Regime

Science.gov (United States)

Demekhov, A. G.

2017-03-01

By using numerical simulations we generalize certain relationships between the parameters of quasimonochromatic whistler-mode waves generated at the linear and nonlinear stages of the cyclotron instability in the backward-wave oscillator regime. One of these relationships is between the wave amplitude at the nonlinear stage and the linear growth rate of the cyclotron instability. It was obtained analytically by V.Yu.Trakhtengerts (1984) for a uniform medium under the assumption of constant frequency and amplitude of the generated wave. We show that a similar relationship also holds for the signals generated in a nonuniform magnetic field and having a discrete structure in the form of short wave packets (elements) with fast frequency drift inside each element. We also generalize the formula for the linear growth rate of absolute cyclotron instability in a nonuniform medium and analyze the relationship between the frequency drift rate in the discrete elements and the wave amplitude. These relationships are important for analyzing the links between the parameters of chorus emissions in the Earth's and planetary magnetospheres and the characteristics of the energetic charged particles generating these signals.

Electromagnetic ion cyclotron waves observed near the oxygen cyclotron frequency by ISEE 1 and 2

International Nuclear Information System (INIS)

Fraser, B.J.; Samson, J.C.; Hu, Y.D.; McPherron, R.L.; Russell, C.T.

1992-01-01

Pc 2 electromagnetic ion cyclotron waves at 0.1 waves at 0.1 Hz, near the oxygen cyclotron frequency, have been observed by ISEE 1 and 2 between L = 7.6 and 5.8 on an inbound near-equatorial pass in the dusk sector. The waves occurred in a thick plasmapause of width ∼ 1.5 R E and penetrated ∼1 R E into the plasmasphere. Wave onset was accompanied by significant increases in the thermal (0-100 eV) He + and the warm (0.1-16 keV/e) O + and He + heavy ion populations. The most intense waves (8 nT) were observed in the outer plasmasphere where convection drift velocities (E x B)/B 2 were largest and the Alfven velocity was a minimum. Wave polarization is predominantly left-handed with propagation almost parallel to the ambient magnetic field, and the spectral slot and polarization reversal predicted by cold plasma propagation theory are identified in the wave data. Poynting fluxes calculated during the first 15 min of the event show wave energy propagation directions both parallel and antiparallel to the field. Computations of the experimental wave spectra during the passage through the plasmapause show that the spectral slots relate to local plasma parameters, possibly suggesting an ion cyclotron wave growth source near the spacecraft. A regular wave packet structure seen over the first 30 min of the event may be attributed to the modulation of this energy source by the Pc 5 waves seen at the same time. Overall, the results are considered an example of an electromagnetic ion cyclotron wave-particle interaction occurring during the outer plasmasphere refilling process at the time of the substorm recovery phase

Heating tokamaks via the ion-cyclotron and ion-ion hybrid resonances

International Nuclear Information System (INIS)

Perkins, F.W.

1977-04-01

For the ion-ion hybrid resonance it is shown that: (1) the energy absorption occurs via a sequence of mode conversions; (2) a poloidal field component normal to the ion-ion hybrid mode conversion surface strongly influences the mode conversion process so that roughly equal electron and ion heating occurs in the present proton-deuterium experiments, while solely electron heating is predicted to prevail in deuterium-tritium reactors; (3) the ion-ion hybrid resonance suppresses toroidal eigenmodes; and (4) wave absorption in minority fundamental ion-cyclotron heating experiments will be dominated by ion-ion hybrid mode conversion absorption for minority concentrations exceeding roughly 1 percent. For the ion-cyclotron resonance, it is shown that: (1) ion-cyclotron mode conversion leads to surface electron heating; and (2) ion-cyclotron mode conversion absorption dominates fundamental ion-cyclotron absorption thereby preventing efficient ion heating

The cross-section data from neutron activation experiments on niobium in the NPI p-7Li quasi-monoenergetic neutron field

Directory of Open Access Journals (Sweden)

Simakov S.P.

2010-10-01

Full Text Available The reaction of protons on 7Li target produces the high-energy quasi- monoenergetic neutron spectrum with the tail to lower energies. Proton energies of 19.8, 25.1, 27.6, 30.1, 32.6, 35.0 and 37.4 MeV were used to obtain quasi-monoenergetic neutrons with energies of 18, 21.6, 24.8, 27.6, 30.3, 32.9 and 35.6 MeV, respectively. Nb cross-section data for neutron energies higher than 22.5 MeV do not exist in the literature. Nb is the important material for fusion applications (IFMIF as well. The variable-energy proton beam of NPI cyclotron is utilized for the production of neutron field using thin lithium target. The carbon backing serves as the beam stopper. The system permits to produce neutron flux density about 109  n/cm2/s in peak at 30 MeV neutron energy. The niobium foils of 15 mm in diameter and approx. 0.75 g weight were activated. The nuclear spectroscopy methods with HPGe detector technique were used to obtain the activities of produced isotopes. The large set of neutron energies used in the experiment allows us to make the complex study of the cross-section values. The reactions (n,2n, (n,3n, (n,4n, (n,He3, (n,α and (n,2nα are studied. The cross-sections data of the (n,4n and (n,2nα are obtained for the first time. The cross-sections of (n,2n and (n,α reactions for higher neutron energies are strongly influenced by low energy tail of neutron spectra. This effect is discussed. The results are compared with the EAF-2007 library.

Ion Cyclotron Resonance Facility (ICR)

Data.gov (United States)

Federal Laboratory Consortium — his facility is charged with developing and exploiting the unique capabilities of Fourier Transform Ion Cyclotron Resonance (FT-ICR) mass spectrometry, and leads the...

Present status of device controls and hardware interfaces for the RCNP ring cyclotron

International Nuclear Information System (INIS)

Yamazaki, T.; Tamura, K.; Hosono, K.

1994-01-01

Since the first proton beam from the injector AVF cyclotron was injected to the ring cyclotron in 1991, the computer control system has been used for the beam acceleration of the ring cyclotron. Some device control modules have been updated, and computer configuration has been changed in 1992. Total control system performs basic facilities almost satisfactory under actual cyclotron operation. (author)

The PET / cyclotron facility at Putrajaya Hospital - an update

International Nuclear Information System (INIS)

Siti Najila Mohd Janib; Suzilawati Muhd Sarowi; Munira Shaikh Nasir; Zulkifli Mohamed Hashim

2006-01-01

Malaysia desire to have a cyclotron for nuclear medical use came into realisation recently with the establishment of a PET/Cyclotron Facility at Putrajaya Hospital. The testing and commissioning of the cyclotron, hot cells, QC equipment and PET/CT started on March 27, culminating in the first patient to be injected on May 10 2006. Three other patients were to be followed on May 15. The patients from both the Kuala Lumpur and Putrajaya Hospital were pre-selected by physicians from these hospitals. The 18 MeV cyclotron is capable of generating 16.4 MeV protons and 8.4 MeV deuterons. The cyclotron at Putrajaya has three targets (2 liquid and 1 gas) and is capable of producing 18 F-FDG and 18 F-DOPA. To complement this, the facility has 2 modules for FDG synthesis, 1 for F-DOPA and 1 for nucleophilic synthesis. The facility will be GMP compliant. For the first production for human use, the water-18 target was irradiated for 50 minutes at 20 mA to produce 1.3 Ci of F-18. At the end of synthesis, the activity of the FDG obtained was 600 mCi. The product was then injected to a 26-year-old female, with a suspected adenocarcinoma. (Author)

Medical use of fast neutrons in radiotherapy and radiography

International Nuclear Information System (INIS)

Bewley, D.K.

1975-01-01

Over 400 patients have been treated with fast neutrons from a cyclotron at Hammersmith Hospital, London, using 16 MeV deuterons on beryllium. A large variety of malignant disease is included in this trial. A randomized trial of fast neutron therapy for cancer of the mouth and throat is in progress and preliminary results will be given. Fast neutron radiographs are often taken to check the positions of the fields used on the patients. These show no contrast from bone, but demonstrate only the presence of gas-filled cavities. As a diagnostic method, fast neutron radiography suffers from a number of disadvantages, the main ones being lack of sensitivity of the image-forming system and the hazard to the patient due to a large Quality Factor. Estimation of the absorbed dose given to different types of tissue is an important factor in the medical use of fast neutrons. More data are needed on the processes whereby fast neutrons impart energy to matter, particularly for neutrons above 15 MeV

Progress report on the Milan superconducting cyclotron

International Nuclear Information System (INIS)

Acerbi, E.; Alessandria, F.; Baccaglioni, G.; Bellomo, G.; Birattari, C.; Bosotti, A.; Broggi, F.; Cortesi, G.; DeMartinis, C.; Fabrici, E.; Ferrari, A.; Giove, D.; Giussani, A.; Giussani, W.; Michelato, P.; Pagani, C.; Rivoltella, G.; Rossi, L.; Serafini, L.; Sussetto, A.; Torri, V.; Varisco, G.; Cuttone, G.; Raia, G.; Kai, L.

1988-01-01