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Sample records for npi cyclotron-based fast

  1. Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17β-estradiol.

    Science.gov (United States)

    Yasrebi, Ali; Hsieh, Anna; Mamounis, Kyle J; Krumm, Elizabeth A; Yang, Jennifer A; Magby, Jason; Hu, Pu; Roepke, Troy A

    2016-02-15

    Ghrelin's receptor, growth hormone secretagogue receptor (GHSR), is highly expressed in the arcuate nucleus (ARC) and in neuropeptide Y (NPY) neurons. Fasting, diet-induced obesity (DIO), and 17β-estradiol (E2) influence ARC Ghsr expression. It is unknown if these effects occur in NPY neurons. Therefore, we examined the expression of Npy, Agrp, and GHSR signaling pathway genes after fasting, DIO, and E2 replacement in ARC and pools of NPY neurons. In males, fasting increased ARC Ghsr and NPY Foxo1 but decreased NPY Ucp2. In males, DIO decreased ARC and NPY Ghsr and Cpt1c. In fed females, E2 increased Agrp, Ghsr, Cpt1c, and Foxo1 in ARC. In NPY pools, E2 decreased Foxo1 in fed females but increased Foxo1 in fasted females. DIO in females suppressed Agrp and augmented Cpt1c in NPY neurons. In summary, genes involved in GHSR signaling are differentially regulated between the ARC and NPY neurons in a sex-dependent manner. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  2. Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17β-estradiol

    Science.gov (United States)

    Yasrebi, Ali; Hsieh, Anna; Mamounis, Kyle J.; Krumm, Elizabeth A.; Yang, Jennifer A.; Magby, Jason; Hu, Pu; Roepke, Troy A.

    2015-01-01

    Ghrelin’s receptor, growth hormone secretagogue receptor (GHSR), is highly expressed in the arcuate nucleus (ARC) and in neuropeptide Y (NPY) neurons. Fasting, diet-induced obesity (DIO), and 17β-estradiol (E2) influence ARC Ghsr expression. It is unknown if these effects occur in NPY neurons. Therefore, we examined the expression of Npy, Agrp, and GHSR signaling pathway genes after fasting, DIO, and E2 replacement in ARC and pools of NPY neurons. In males, fasting increased ARC Ghsr and NPY Foxo1 but decreased NPY Ucp2. In males, DIO decreased ARC and NPY Ghsr and Cpt1c. In fed females, E2 increased Agrp, Ghsr, Cpt1c, and Foxo1 in ARC. In NPY pools, E2 decreased Foxo1 in fed females but increased Foxo1 in fasted females. DIO in females suppressed Agrp and augmented Cpt1c in NPY neurons. In summary, genes involved in GHSR signaling are differentially regulated between the ARC and NPY neurons in a sex-dependent manner. PMID:26577678

  3. Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response.

    Science.gov (United States)

    Wang, Qiao-Ping; Lin, Yong Qi; Zhang, Lei; Wilson, Yana A; Oyston, Lisa J; Cotterell, James; Qi, Yue; Khuong, Thang M; Bakhshi, Noman; Planchenault, Yoann; Browman, Duncan T; Lau, Man Tat; Cole, Tiffany A; Wong, Adam C N; Simpson, Stephen J; Cole, Adam R; Penninger, Josef M; Herzog, Herbert; Neely, G Gregory

    2016-07-12

    Non-nutritive sweeteners like sucralose are consumed by billions of people. While animal and human studies have demonstrated a link between synthetic sweetener consumption and metabolic dysregulation, the mechanisms responsible remain unknown. Here we use a diet supplemented with sucralose to investigate the long-term effects of sweet/energy imbalance. In flies, chronic sweet/energy imbalance promoted hyperactivity, insomnia, glucose intolerance, enhanced sweet taste perception, and a sustained increase in food and calories consumed, effects that are reversed upon sucralose removal. Mechanistically, this response was mapped to the ancient insulin, catecholamine, and NPF/NPY systems and the energy sensor AMPK, which together comprise a novel neuronal starvation response pathway. Interestingly, chronic sweet/energy imbalance promoted increased food intake in mammals as well, and this also occurs through an NPY-dependent mechanism. Together, our data show that chronic consumption of a sweet/energy imbalanced diet triggers a conserved neuronal fasting response and increases the motivation to eat. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. Y2 receptor signalling in NPY neurons controls bone formation and fasting induced feeding but not spontaneous feeding.

    Science.gov (United States)

    Qi, Yue; Fu, Melissa; Herzog, Herbert

    2016-02-01

    Y2 receptors have been implicated in the development of obesity and are a potential target for obesity treatment due to their known role of inhibiting neuropeptide Y (NPY) induced feeding responses. However, the precise neuronal population on which Y2 receptors act to fulfil this role is less clear. Here we utilise a novel inducible, postnatal onset NPY neurons specific deletion model to investigate the functional consequences of loss of Y2 signalling in this population of neurons on feeding and energy homeostasis regulation. While the consequences of lack of Y2 signalling in NPY neurons are confirmed in terms of the uncoupling of suppression/increasing of NPY and pro-opiomelanocortin (POMC) mRNA expression in the arcuate nuclei (Arc), respectively, this lack of Y2 signalling surprisingly does not have any significant effect on spontaneous food intake. Fasting induced food intake, however, is strongly increased but only in the first 1h after re-feeding. Consequently no significant changes in body weight are being observed although body weight gain is increased in male mice after postnatal onset Y2 deletion. Importantly, another known function of central Y2 receptor signalling, the suppression of bone formation is conserved in this conditional model with whole body bone mineral content being decreased. Taken together this model confirms the critical role of Y2 signalling to control NPY and associated POMC expression in the Arc, but also highlights the possibility that others, non-NPY neuronal Y2 receptors, are also involved in controlling feeding and energy homeostasis regulation. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. Neuropeptide Y (NPY), cocaine- and amphetamine-regulated transcript (CART) and cholecystokinin (CCK) in winter skate (Raja ocellata): cDNA cloning, tissue distribution and mRNA expression responses to fasting.

    Science.gov (United States)

    MacDonald, Erin; Volkoff, Hélène

    2009-04-01

    cDNAs encoding for neuropeptide Y (NPY), cocaine- and amphetamine-regulated transcript (CART) and cholecystokinin (CCK) were cloned in an elasmobranch fish, the winter skate. mRNA tissue distribution was examined for the three peptides as well as the effects of two weeks of fasting on their expression. Skate NPY, CART and CCK sequences display similarities with sequences for teleost fish but in general the degree of identity is relatively low (50%). All three peptides are present in brain and in several peripheral tissues, including gut and gonads. Within the brain, the three peptides are expressed in the hypothalamus, telencephalon, optic tectum and cerebellum. Two weeks of fasting induced an increase in telencephalon NPY and an increase in CCK in the gut but had no effects on hypothalamic NPY, CART and CCK, or on telencephalon CART. Our results provide basis for further investigation into the regulation of feeding in winter skate.

  6. Cyclotron-based neutron source for BNCT

    Energy Technology Data Exchange (ETDEWEB)

    Mitsumoto, T.; Yajima, S.; Tsutsui, H.; Ogasawara, T.; Fujita, K. [Sumitomo Heavy Industries, Ltd (Japan); Tanaka, H.; Sakurai, Y.; Maruhashi, A. [Kyoto University Research Reactor Institute (Japan)

    2013-04-19

    Kyoto University Research Reactor Institute (KURRI) and Sumitomo Heavy Industries, Ltd. (SHI) have developed a cyclotron-based neutron source for Boron Neutron Capture Therapy (BNCT). It was installed at KURRI in Osaka prefecture. The neutron source consists of a proton cyclotron named HM-30, a beam transport system and an irradiation and treatment system. In the cyclotron, H- ions are accelerated and extracted as 30 MeV proton beams of 1 mA. The proton beams is transported to the neutron production target made by a beryllium plate. Emitted neutrons are moderated by lead, iron, aluminum and calcium fluoride. The aperture diameter of neutron collimator is in the range from 100 mm to 250 mm. The peak neutron flux in the water phantom is 1.8 Multiplication-Sign 109 neutrons/cm{sup 2}/sec at 20 mm from the surface at 1 mA proton beam. The neutron source have been stably operated for 3 years with 30 kW proton beam. Various pre-clinical tests including animal tests have been done by using the cyclotron-based neutron source with {sup 10}B-p-Borono-phenylalanine. Clinical trials of malignant brain tumors will be started in this year.

  7. NPY modulates PYY function in the regulation of energy balance and glucose homeostasis.

    Science.gov (United States)

    Zhang, L; Nguyen, A D; Lee, I-C J; Yulyaningsih, E; Riepler, S J; Stehrer, B; Enriquez, R F; Lin, S; Shi, Y-C; Baldock, P A; Sainsbury, A; Herzog, H

    2012-08-01

    Both the neuronal-derived neuropeptide Y (NPY) and the gut hormone peptide YY (PYY) have been implicated in the regulation of energy balance and glucose homeostasis. However, despite similar affinities for the same Y receptors, the co-ordinated actions of these two peptides in energy and glucose homeostasis remain largely unknown. To investigate the mechanisms and possible interactions between PYY with NPY in the regulation of these processes, we utilized NPY/PYY single and double mutant mouse models and examined parameters of energy balance and glucose homeostasis. PYY(-/-) mice exhibited increased fasting-induced food intake, enhanced fasting and oral glucose-induced serum insulin levels, and an impaired insulin tolerance, - changes not observed in NPY(-/-) mice. Interestingly, whereas PYY deficiency-induced impairment in insulin tolerance remained in NPY(-/-) PYY(-/-) mice, effects of PYY deficiency on fasting-induced food intake and serum insulin concentrations at baseline and after the oral glucose bolus were absent in NPY(-/-) PYY(-/-) mice, suggesting that NPY signalling may be required for PYY's action on insulin secretion and fasting-induced hyperphagia. Moreover, NPY(-/-) PYY(-/-) , but not NPY(-/-) or PYY(-/-) mice had significantly decreased daily food intake, indicating interactive control by NPY and PYY on spontaneous food intake. Furthermore, both NPY(-/-) and PYY(-/-) mice showed significantly reduced respiratory exchange ratio during the light phase, with no additive effects observed in NPY(-/-) PYY(-/-) mice, indicating that NPY and PYY may regulate oxidative fuel selection via partly shared mechanisms. Overall, physical activity and energy expenditure, however, are not significantly altered by NPY and PYY single or double deficiencies. These findings show significant and diverse interactions between NPY and PYY signalling in the regulation of different aspects of energy balance and glucose homeostasis. © 2012 Blackwell Publishing Ltd.

  8. Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weight.

    Directory of Open Access Journals (Sweden)

    Paul A Baldock

    Full Text Available Changes in whole body energy levels are closely linked to alterations in body weight and bone mass. Here, we show that hypothalamic signals contribute to the regulation of bone mass in a manner consistent with the central perception of energy status. Mice lacking neuropeptide Y (NPY, a well-known orexigenic factor whose hypothalamic expression is increased in fasting, have significantly increased bone mass in association with enhanced osteoblast activity and elevated expression of bone osteogenic transcription factors, Runx2 and Osterix. In contrast, wild type and NPY knockout (NPY (-/- mice in which NPY is specifically over expressed in the hypothalamus (AAV-NPY+ show a significant reduction in bone mass despite developing an obese phenotype. The AAV-NPY+ induced loss of bone mass is consistent with models known to mimic the central effects of fasting, which also show increased hypothalamic NPY levels. Thus these data indicate that, in addition to well characterized responses to body mass, skeletal tissue also responds to the perception of nutritional status by the hypothalamus independently of body weight. In addition, the reduction in bone mass by AAV NPY+ administration does not completely correct the high bone mass phenotype of NPY (-/- mice, indicating the possibility that peripheral NPY may also be an important regulator of bone mass. Indeed, we demonstrate the expression of NPY specifically in osteoblasts. In conclusion, these data identifies NPY as a critical integrator of bone homeostatic signals; increasing bone mass during times of obesity when hypothalamic NPY expression levels are low and reducing bone formation to conserve energy under 'starving' conditions, when hypothalamic NPY expression levels are high.

  9. A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism.

    Science.gov (United States)

    He, Yanlin; Shu, Gang; Yang, Yongjie; Xu, Pingwen; Xia, Yan; Wang, Chunmei; Saito, Kenji; Hinton, Antentor; Yan, Xiaofeng; Liu, Chen; Wu, Qi; Tong, Qingchun; Xu, Yong

    2016-11-08

    Neurons that co-express agouti-related peptide (AgRP) and neuropeptide Y (NPY) are indispensable for normal feeding behavior. Firing activities of AgRP/NPY neurons are dynamically regulated by energy status and coordinate appropriate feeding behavior to meet nutritional demands. However, intrinsic mechanisms that regulate AgRP/NPY neural activities during the fed-to-fasted transition are not fully understood. We found that AgRP/NPY neurons in satiated mice express high levels of the small-conductance calcium-activated potassium channel 3 (SK3) and are inhibited by SK3-mediated potassium currents; on the other hand, food deprivation suppresses SK3 expression in AgRP/NPY neurons, and the decreased SK3-mediated currents contribute to fasting-induced activation of these neurons. Genetic mutation of SK3 specifically in AgRP/NPY neurons leads to increased sensitivity to diet-induced obesity, associated with chronic hyperphagia and decreased energy expenditure. Our results identify SK3 as a key intrinsic mediator that coordinates nutritional status with AgRP/NPY neural activities and animals' feeding behavior and energy metabolism. Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

  10. Knowledge and experiences of needle prick injuries (NPI) among ...

    African Journals Online (AJOL)

    Data collected included factors contributing to NPI and high-risk procedures leading to NPI, as perceived by these students. A knowledge assessment of NPI guidelines, policies and protocols and prevalence of NPI among these students was also done. Results: A response rate of 96 (74%) was achieved. The average age ...

  11. Cyclotron based nuclear science. Progress report, April 1, 1985-March 31, 1986

    International Nuclear Information System (INIS)

    Youngblood, D.H.

    1986-08-01

    Progress report for cyclotron based nuclear science cyclotron facility are summarized. Research is described under the headings heavy ion reactions, nuclear theory, atomic studies and activation analysis, superconducting cyclotron and instrumentation. Publications are listed

  12. The Neuropsychiatric Inventory--NPI. Validation of the Danish version

    DEFF Research Database (Denmark)

    Korner, A.; Lauritzen, Lotte; Lolk, A.

    2008-01-01

    NPI and NPI-VAS were high; only two domains had coefficients below 0.60: depression and agitation/aggression. NPI-total scores increase with increasing severity of dementia. The NPI did not fulfil the scalability assessed by the Mokken and Loevinger coefficients. The NPI Danish version is valid......Assessment of neuropsychiatric symptoms in dementia has great clinical importance. The aim of the study was validation of the Danish version of the NPI, using assessments of 72 demented and 29 non-demented of age 65+ years and their caregivers at three visits. The NPI was administered by the same...... and reliable in assessing neuropsychiatric symptoms in dementia but not fully scalable. The use of single item scores and not total sum score is recommended Udgivelsesdato: 2008...

  13. The role of NPY in learning and memory

    DEFF Research Database (Denmark)

    Gøtzsche, C. R.; Woldbye, D. P. D.

    2016-01-01

    with Y1 receptor-mediated neurogenesis could constitute necessary steps in consolidation and long-term retention of spatial memory. Altogether, NPY-induced effects on learning and memory seem to be biphasic, anatomically and temporally differential, and in support of a modulatory role of NPY at keeping......High levels of NPY expression in brain regions important for learning and memory together with its neuromodulatory and neurotrophic effects suggest a regulatory role for NPY in memory processes. Therefore it is not surprising that an increasing number of studies have provided evidence for NPY...... acting as a modulator of neuroplasticity, neurotransmission, and memory. Here these results are presented in relation to the types of memory affected by NPY and its receptors. NPY can exert both inhibitory and stimulatory effects on memory, depending on memory type and phase, dose applied, brain region...

  14. The role of NPY in learning and memory.

    Science.gov (United States)

    Gøtzsche, C R; Woldbye, D P D

    2016-02-01

    High levels of NPY expression in brain regions important for learning and memory together with its neuromodulatory and neurotrophic effects suggest a regulatory role for NPY in memory processes. Therefore it is not surprising that an increasing number of studies have provided evidence for NPY acting as a modulator of neuroplasticity, neurotransmission, and memory. Here these results are presented in relation to the types of memory affected by NPY and its receptors. NPY can exert both inhibitory and stimulatory effects on memory, depending on memory type and phase, dose applied, brain region, and NPY receptor subtypes. Thus NPY act as a resilience factor by impairing associative implicit memory after stressful and aversive events, as evident in models of fear conditioning, presumably via Y1 receptors in the amygdala and prefrontal cortex. In addition, NPY impairs acquisition but enhances consolidation and retention in models depending on spatial and discriminative types of associative explicit memory, presumably involving Y2 receptor-mediated regulations of hippocampal excitatory transmission. Moreover, spatial memory training leads to increased hippocampal NPY gene expression that together with Y1 receptor-mediated neurogenesis could constitute necessary steps in consolidation and long-term retention of spatial memory. Altogether, NPY-induced effects on learning and memory seem to be biphasic, anatomically and temporally differential, and in support of a modulatory role of NPY at keeping the system in balance. Obtaining further insight into memory-related effects of NPY could inspire the engineering of new therapeutics targeting diseases where impaired learning and memory are central elements. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Insulin controls food intake and energy balance via NPY neurons

    Directory of Open Access Journals (Sweden)

    Kim Loh

    2017-06-01

    Full Text Available Objectives: Insulin signaling in the brain has been implicated in the control of satiety, glucose homeostasis and energy balance. However, insulin signaling is dispensable in energy homeostasis controlling AgRP or POMC neurons and it is unclear which other neurons regulate these effects. Here we describe an ancient insulin/NPY neuronal network that governs energy homeostasis across phyla. Methods: To address the role of insulin action specifically in NPY neurons, we generated a variety of models by selectively removing insulin signaling in NPY neurons in flies and mice and testing the consequences on energy homeostasis. Results: By specifically targeting the insulin receptor in both fly and mouse NPY expressing neurons, we found NPY-specific insulin signaling controls food intake and energy expenditure, and lack of insulin signaling in NPY neurons leads to increased energy stores and an obese phenotype. Additionally, the lack of insulin signaling in NPY neurons leads to a dysregulation of GH/IGF-1 axis and to altered insulin sensitivity. Conclusions: Taken together, these results suggest that insulin actions in NPY neurons is critical for maintaining energy balance and an impairment of this pathway may be causally linked to the development of metabolic diseases. Keywords: Hypothalamus, NPY, Insulin, Obesity

  16. Lipopolysaccharide (LPS) and tumor necrosis factor alpha (TNFα) blunt the response of Neuropeptide Y/Agouti-related peptide (NPY/AgRP) glucose inhibited (GI) neurons to decreased glucose.

    Science.gov (United States)

    Hao, Lihong; Sheng, Zhenyu; Potian, Joseph; Deak, Adam; Rohowsky-Kochan, Christine; Routh, Vanessa H

    2016-10-01

    A population of Neuropeptide Y (NPY) neurons which co-express Agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus (ARC) are inhibited at physiological levels of brain glucose and activated when glucose levels decline (e.g. glucose-inhibited or GI neurons). Fasting enhances the activation of NPY/AgRP-GI neurons by low glucose. In the present study we tested the hypothesis that lipopolysaccharide (LPS) inhibits the enhanced activation of NPY/AgRP-GI neurons by low glucose following a fast. Mice which express green fluorescent protein (GFP) on their NPY promoter were used to identify NPY/AgRP neurons. Fasting for 24h and LPS injection decreased blood glucose levels. As we have found previously, fasting increased c-fos expression in NPY/AgRP neurons and increased the activation of NPY/AgRP-GI neurons by decreased glucose. As we predicted, LPS blunted these effects of fasting at the 24h time point. Moreover, the inflammatory cytokine tumor necrosis factor alpha (TNFα) blocked the activation of NPY/AgRP-GI neurons by decreased glucose. These data suggest that LPS and TNFα may alter glucose and energy homeostasis, in part, due to changes in the glucose sensitivity of NPY/AgRP neurons. Interestingly, our findings also suggest that NPY/AgRP-GI neurons use a distinct mechanism to sense changes in extracellular glucose as compared to our previous studies of GI neurons in the adjacent ventromedial hypothalamic nucleus. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Technical Note: Defining cyclotron-based clinical scanning proton machines in a FLUKA Monte Carlo system.

    Science.gov (United States)

    Fiorini, Francesca; Schreuder, Niek; Van den Heuvel, Frank

    2018-02-01

    Cyclotron-based pencil beam scanning (PBS) proton machines represent nowadays the majority and most affordable choice for proton therapy facilities, however, their representation in Monte Carlo (MC) codes is more complex than passively scattered proton system- or synchrotron-based PBS machines. This is because degraders are used to decrease the energy from the cyclotron maximum energy to the desired energy, resulting in a unique spot size, divergence, and energy spread depending on the amount of degradation. This manuscript outlines a generalized methodology to characterize a cyclotron-based PBS machine in a general-purpose MC code. The code can then be used to generate clinically relevant plans starting from commercial TPS plans. The described beam is produced at the Provision Proton Therapy Center (Knoxville, TN, USA) using a cyclotron-based IBA Proteus Plus equipment. We characterized the Provision beam in the MC FLUKA using the experimental commissioning data. The code was then validated using experimental data in water phantoms for single pencil beams and larger irregular fields. Comparisons with RayStation TPS plans are also presented. Comparisons of experimental, simulated, and planned dose depositions in water plans show that same doses are calculated by both programs inside the target areas, while penumbrae differences are found at the field edges. These differences are lower for the MC, with a γ(3%-3 mm) index never below 95%. Extensive explanations on how MC codes can be adapted to simulate cyclotron-based scanning proton machines are given with the aim of using the MC as a TPS verification tool to check and improve clinical plans. For all the tested cases, we showed that dose differences with experimental data are lower for the MC than TPS, implying that the created FLUKA beam model is better able to describe the experimental beam. © 2017 The Authors. Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists

  18. Regulation of hypothalamic NPY by diet and smoking.

    Science.gov (United States)

    Chen, Hui; Hansen, Michelle J; Jones, Jessica E; Vlahos, Ross; Bozinovski, Steve; Anderson, Gary P; Morris, Margaret J

    2007-02-01

    Appetite is regulated by a number of hypothalamic neuropeptides including neuropeptide Y (NPY), a powerful feeding stimulator that responds to feeding status, and drugs such as nicotine and cannabis. There is debate regarding the extent of the influence of obesity on hypothalamic NPY. We measured hypothalamic NPY in male Sprague-Dawley rats after short or long term exposure to cafeteria-style high fat diet (32% energy as fat) or laboratory chow (12% fat). Caloric intake and body weight were increased in the high fat diet group, and brown fat and white fat masses were significantly increased after 2 weeks. Hypothalamic NPY concentration was only significantly decreased after long term consumption of the high fat diet. Nicotine decreases food intake and body weight, with conflicting effects on hypothalamic NPY reported. Body weight, plasma hormones and brain NPY were investigated in male Balb/c mice exposed to cigarette smoke for 4 days, 4 and 12 weeks. Food intake was significantly decreased by smoke exposure (2.32+/-0.03g/24h versus 2.71+/-0.04g/24h in control mice (non-smoke exposed) at 12 weeks). Relative to control mice, smoke exposure led to greater weight loss, while pair-feeding the equivalent amount of chow caused an intermediate weight loss. Chronic smoke exposure, but not pair-feeding, was associated with decreased hypothalamic NPY concentration, suggesting an inhibitory effect of cigarette smoking on brain NPY levels. Thus, consumption of a high fat diet and smoke exposure reprogram hypothalamic NPY. Reduced NPY may contribute to the anorexic effect of smoke exposure.

  19. NPI one year on [Framatome-Siemens common product

    International Nuclear Information System (INIS)

    Ruess, F.; Lebreton, G.

    1990-01-01

    Nuclear Power International (NPI), a joint subsidiary of Framatome and Siemens was established in April 1989 to coordinate the development and marketing of a common PWR technology for the world market. Both parent companies command well proven PWR technology and can rely on experience gained with over 100 000MWe of nuclear capacity in operation, under construction or on order. The technology from each is being offered through NPI until the joint PWR technology which is under development, becomes available. NPI's experience to date is reviewed. (author)

  20. Health physics and quality control management of a cyclotron-based PET facility

    International Nuclear Information System (INIS)

    Jerabek, P.A.

    1995-01-01

    This paper provides an overview of the operation and management of a Positron Emission Tomography (PET) facility at the University of Texas. The facility components are discussed from an operations perspective with an emphasis on devices, and on practices and procedures which are implemented to ensure that personnel exposures are as low as reasonably achievable. The cyclotron-based PET facility uses in-house production of PET radioisotopes for preparation of radiopharmaceuticals. A combination of specially designed cyclotron equipped devices, radiopharmaceutical preparation devices, and shielded devices along with health physics practices have helped to make PET operations become routine

  1. Knowledge and experiences of needle prick injuries (NPI) among ...

    African Journals Online (AJOL)

    of acquiring blood-borne infections from the workplace. ... Adequate knowledge and adherence to safety practices could prevent the occurrence of NPI and the related ..... managers, develop surveillance systems, immunise against hepatitis.

  2. NPY/AgRP neurons are not essential for feeding responses to glucoprivation.

    Science.gov (United States)

    Luquet, Serge; Phillips, Colin T; Palmiter, Richard D

    2007-02-01

    Animals respond to hypoglycemia by eating and by stimulating gluconeogenesis. These responses to glucose deprivation are initiated by glucose-sensing neurons in the brain, but the neural circuits that control feeding behavior are not well established. Neurons in the arcuate region of the hypothalamus that express neuropeptide Y (NPY) and agouti-related protein (AgRP) have been implicated in mediating the feeding response to glucoprivation. We devised a method to selectively ablate these neurons in neonatal mice and then tested adult mice for their feeding responses to fasting, mild hypoglycemia, 2-deoxy-d-glucose and a ghrelin receptor agonist. Whereas the feeding response to the ghrelin receptor agonist was completely abrogated, the feeding response to glucoprivation was normal. The feeding response after a fast was attenuated when standard chow was available but normal with more palatable solid or liquid diet. We conclude that NPY/AgRP neurons are not necessary for generating or mediating the orexigenic response to glucose deficiency, but they are essential for the feeding response to ghrelin and refeeding on standard chow after a fast.

  3. Direct versus indirect actions of ghrelin on hypothalamic NPY neurons.

    Science.gov (United States)

    Hashiguchi, Hiroshi; Sheng, Zhenyu; Routh, Vanessa; Gerzanich, Volodymyr; Simard, J Marc; Bryan, Joseph

    2017-01-01

    Assess direct versus indirect action(s) of ghrelin on hypothalamic NPY neurons. Electrophysiology was used to measure ion channel activity in NPY-GFP neurons in slice preparations. Ca2+ imaging was used to monitor ghrelin activation of isolated NPY GFP-labeled neurons. Immunohistochemistry was used to localize Trpm4, SUR1 and Kir6.2 in the hypothalamus. Acylated ghrelin depolarized the membrane potential (MP) of NPY-GFP neurons in brain slices. Depolarization resulted from a decreased input resistance (IR) in ~70% of neurons (15/22) or an increased IR in the remainder (7/22), consistent with the opening or closing of ion channels, respectively. Although tetrodotoxin (TTX) blockade of presynaptic action potentials reduced ghrelin-induced changes in MP and IR, ghrelin still significantly depolarized the MP and decreased IR in TTX-treated neurons, suggesting that ghrelin directly opens cation channel(s) in NPY neurons. In isolated NPY-GFP neurons, ghrelin produced a sustained rise of [Ca2+]c, with an EC50 ~110 pM. Pharmacologic studies confirmed that the direct action of ghrelin was through occupation of the growth hormone secretagogue receptor, GHS-R, and demonstrated the importance of the adenylate cyclase/cAMP/protein kinase A (PKA) and phospholipase C/inositol triphosphate (PLC/IP3) pathways as activators of 5' AMP-activated protein kinase (AMPK). Activation of isolated neurons was not affected by CNQX or TTX, but reducing [Na+]o suppressed activation, suggesting a role for Na+-permeable cation channels. SUR1 and two channel partners, Kir6.2 and Trpm4, were identified immunologically in NPY-GFP neurons in situ. The actions of SUR1 and Trpm4 modulators were informative: like ghrelin, diazoxide, a SUR1 agonist, elevated [Ca2+]c and glibenclamide, a SUR1 antagonist, partially suppressed ghrelin action, while 9-phenanthrol and flufenamic acid, selective Trpm4 antagonists, blocked ghrelin actions on isolated neurons. Ghrelin activation was unaffected by nifedipine and

  4. Validity of the Brazilian version of the Neuropsychiatric Inventory Questionnaire (NPI-Q

    Directory of Open Access Journals (Sweden)

    Ana Luiza Camozzato

    2015-01-01

    Full Text Available The NPI-Q (Neuropsychiatry Inventory-Questionnaire was developed to facilitate the evaluation of neuropsychiatric symptoms. This study evaluated the internal consistency, the test-retest reliability of the Brazilian NPI-Q version and its convergent validity with the original NPI. Method The NPI-Q and the NPI were administered to 64 caregivers of dementia patients. Thirteen informants were asked to complete a second NPI-Q form. Results The internal consistency of the Brazilian NPI-Q version was 0.67 for the severity scale and 0.81 for the distress scale. The test-retest reliability of the total NPI-Q severity and the distress scales were 0.97 and 0.92, respectively (p < 0.001. There were significant correlations between the total NPI-Q severity score and the NPI (r = 0.75 and between the total NPI-Q distress score and the total NPI standard distress (r = 0.74. Conclusion The Brazilian NPI-Q version showed evidence of good psychometric properties and can be used in general clinical practice.

  5. The Role of Neuropeptide Y (NPY) in Uncontrolled Alcohol Drinking and Relapse Behavior Resulting from Exposure to Stressful Events

    National Research Council Canada - National Science Library

    Thiele, Todd E; Knapp, Darin J; Breese, George; McCown, Thomas J

    2007-01-01

    .... An interesting candidate is neuropeptide Y (NPY). Recent evidence suggests that low NPY levels promote high alcohol consumption, and it has been established the NPY protects against stress and anxiety...

  6. Genetic modulation of plasma NPY stress response is suppressed in substance abuse: association with clinical outcomes.

    Science.gov (United States)

    Xu, Ke; Hong, Kwangik Adam; Zhou, Zhifeng; Hauger, Richard L; Goldman, David; Sinha, Rajita

    2012-04-01

    Neuropeptide Y (NPY) is involved in stress regulation. Genetic variations predict plasma NPY and neural correlates of emotion and stress. We examined whether the functional NPY haplotype modulates stress-induced NPY and anxiety responses, and if plasma NPY stress responses are associated with substance dependence outcomes. Thirty-seven treatment-engaged, abstinent substance dependent (SD) patients and 28 healthy controls (HCs) characterized on NPY diplotypes (HH: high expression; HLLL: intermediate/low expression) were exposed to stress, alcohol/drug cues and neutral relaxing cues, using individualized guided imagery, in a 3-session laboratory experiment. Plasma NPY, heart rate and anxiety were assessed. Patients were prospectively followed for 90-days post-treatment to assess relapse outcomes. HH individuals showed significantly lower stress-induced NPY with greater heart rate and anxiety ratings, while the HLLL group showed the reverse pattern of NPY, anxiety and heart rate responses. This differential genetic modulation of NPY stress response was suppressed in the SD group, who showed no stress-related increases in NPY and higher heart rate and greater anxiety, regardless of diplotype. Lower NPY predicted subsequent higher number of days and greater amounts of post-treatment drug use. These preliminary findings are the first to document chronic drug abuse influences on NPY diplotype expression where NPY diplotype modulation of stress-related plasma NPY, heart rate and anxiety responses was absent in the substance abuse sample. The finding that lower stress-related NPY is predictive of greater relapse severity provides support for therapeutic development of neuropeptide Y targets in the treatment of substance use disorders. Copyright © 2011 Elsevier Ltd. All rights reserved.

  7. NPY2-receptor variation modulates iconic memory processes.

    Science.gov (United States)

    Arning, Larissa; Stock, Ann-Kathrin; Kloster, Eugen; Epplen, Jörg T; Beste, Christian

    2014-08-01

    Sensory memory systems are modality-specific buffers that comprise information about external stimuli, which represent the earliest stage of information processing. While these systems have been the subject of cognitive neuroscience research for decades, little is known about the neurobiological basis of sensory memory. However, accumulating evidence suggests that the glutamatergic system and systems influencing glutamatergic neural transmission are important. In the current study we examine if functional promoter variations in neuropeptide Y (NPY) and its receptor gene NPY2R affect iconic memory processes using a partial report paradigm. We found that iconic memory decayed much faster in individuals carrying the rare promoter NPY2R G allele which is associated with increased expression of the Y2 receptor. Possibly this effect is due to altered presynaptic inhibition of glutamate release, known to be modulated by Y2 receptors. Altogether, our results provide evidence that the functionally relevant single nucleotide polymorphism (SNP) in the NPY2R promoter gene affect circumscribed processes of early sensory processing, i.e. only the stability of information in sensory memory buffers. This leads us to suggest that especially the stability of information in sensory memory buffers depends on glutamatergic neural transmission and factors modulating glutamatergic turnover. Copyright © 2014 Elsevier B.V. and ECNP. All rights reserved.

  8. Interaction between neuropeptide Y (NPY) and brain-derived neurotrophic factor in NPY-mediated neuroprotection against excitotoxicity

    DEFF Research Database (Denmark)

    Xapelli, S; Bernardino, L; Ferreira, R

    2008-01-01

    The neuroprotective effect of neuropeptide Y (NPY) receptor activation was investigated in organotypic mouse hippocampal slice cultures exposed to the glutamate receptor agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA). Exposure of 2-week-old slice cultures, derived from 7-...

  9. Release of NPY in pig pancreas: Dual parasympathetic and sympathetic regulation

    International Nuclear Information System (INIS)

    Sheikh, S.P.; Holst, J.J.; Skak-Nielsen, T.; Knigge, U.; Warberg, J.; Theodorsson-Norheim, E.; Hoekfelt, T.; Lundberg, J.M.; Schwartz, T.W.

    1988-01-01

    Several lines of evidence have connected neuropeptide Y (NPY), a 36-residue polypeptide, to the sympathetic division of the autonomic nervous system. The authors studied the localization, the molecular characteristics, and the release of NPY and norepinephrine (NE) in the porcine pancreas. Immunohistochemical investigations revealed that NPY nerves around blood vessels were likely to be of adrenergic nature, whereas NPY-immunoreactive fibers close to exocrine and endocrine cells may originate from local ganglia also containing VIP (vasoactive intestinal peptide) and PHI (peptide histidine isoleucine). Electrical stimulation of the splanchnic nerve supply to the isolated perfused pig pancreas resulted in a corelease of NPY and NE into the venous effluent. Stimulation of the vagal nerves caused a sevenfold larger release of NPY without affecting the NE secretion. Characterization of the NPY immunoreactivity in the pancreatic tissue and in the venous effluent by gel filtration, high-performance liquid chromatography, and isoelectric focusing shoed that the immunoreactive NPY was indistinguishable from synthetic porcine NPY. It is concluded that, although NPY is associated with sympathetic perivascular neurons, the majority of the pancreatic NPY-containing nerve fibers are likely to belong to the parasympathetic division of the autonomic nervous system

  10. Intraperitoneal injection of neuropeptide Y (NPY) alters neurotrophin rat hypothalamic levels: Implications for NPY potential role in stress-related disorders.

    Science.gov (United States)

    Gelfo, Francesca; De Bartolo, Paola; Tirassa, Paola; Croce, Nicoletta; Caltagirone, Carlo; Petrosini, Laura; Angelucci, Francesco

    2011-06-01

    Neuropeptide Y (NPY) is a 36-amino acid peptide which exerts several regulatory actions within peripheral and central nervous systems. Among NPY actions preclinical and clinical data have suggested that the anxiolytic and antidepressant actions of NPY may be related to its antagonist action on the hypothalamic-pituitary-adrenal (HPA) axis. The neurotrophins brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are proteins involved in the growth, survival and function of neurons. In addition to this, a possible role of neurotrophins, particularly BDNF, in HPA axis hyperactivation has been proposed. To characterize the effect of NPY on the production of neurotrophins in the hypothalamus we exposed young adult rats to NPY intraperitoneal administration for three consecutive days and then evaluated BDNF and NGF synthesis in this brain region. We found that NPY treatment decreased BDNF and increased NGF production in the hypothalamus. Given the role of neurotrophins in the hypothalamus, these findings, although preliminary, provide evidence for a role of NPY as inhibitor of HPA axis and support the idea that NPY might be involved in pathologies characterized by HPA axis dysfunctions. Copyright © 2011 Elsevier Inc. All rights reserved.

  11. Pancreatic polypeptide controls energy homeostasis via Npy6r signaling in the suprachiasmatic nucleus in mice.

    Science.gov (United States)

    Yulyaningsih, Ernie; Loh, Kim; Lin, Shu; Lau, Jackie; Zhang, Lei; Shi, Yanchuan; Berning, Britt A; Enriquez, Ronaldo; Driessler, Frank; Macia, Laurence; Khor, Ee Cheng; Qi, Yue; Baldock, Paul; Sainsbury, Amanda; Herzog, Herbert

    2014-01-07

    Y-receptors control energy homeostasis, but the role of Npy6 receptors (Npy6r) is largely unknown. Young Npy6r-deficient (Npy6r(-/-)) mice have reduced body weight, lean mass, and adiposity, while older and high-fat-fed Npy6r(-/-) mice have low lean mass with increased adiposity. Npy6r(-/-) mice showed reduced hypothalamic growth hormone releasing hormone (Ghrh) expression and serum insulin-like growth factor-1 (IGF-1) levels relative to WT. This is likely due to impaired vasoactive intestinal peptide (VIP) signaling in the suprachiasmatic nucleus (SCN), where we found Npy6r coexpressed in VIP neurons. Peripheral administration of pancreatic polypeptide (PP) increased Fos expression in the SCN, increased energy expenditure, and reduced food intake in WT, but not Npy6r(-/-), mice. Moreover, intraperitoneal (i.p.) PP injection increased hypothalamic Ghrh mRNA expression and serum IGF-1 levels in WT, but not Npy6r(-/-), mice, an effect blocked by intracerebroventricular (i.c.v.) Vasoactive Intestinal Peptide (VPAC) receptors antagonism. Thus, PP-initiated signaling through Npy6r in VIP neurons regulates the growth hormone axis and body composition. Copyright © 2014 Elsevier Inc. All rights reserved.

  12. FAST

    DEFF Research Database (Denmark)

    Zuidmeer-Jongejan, Laurian; Fernandez-Rivas, Montserrat; Poulsen, Lars K.

    2012-01-01

    ABSTRACT: The FAST project (Food Allergy Specific Immunotherapy) aims at the development of safe and effective treatment of food allergies, targeting prevalent, persistent and severe allergy to fish and peach. Classical allergen-specific immunotherapy (SIT), using subcutaneous injections with aqu...

  13. Arcuate NPY neurons sense and integrate peripheral metabolic signals to control feeding.

    Science.gov (United States)

    Kohno, Daisuke; Yada, Toshihiko

    2012-12-01

    NPY neuron in the hypothalamic arcuate nucleus is a key feeding center. Studies have shown that NPY neuron in the arcuate nucleus has a role to induce food intake. The arcuate nucleus is structurally unique with lacking blood brain barrier. Peripheral energy signals including hormones and nutrition can reach the arcuate nucleus. In this review, we discuss sensing and integrating peripheral signals in NPY neurons. In the arcuate nucleus, ghrelin mainly activates NPY neurons. Leptin and insulin suppress the ghrelin-induced activation in 30-40% of the ghrelin-activated NPY neurons. Lowering glucose concentration activates 40% of NPY neurons. These results indicate that NPY neuron in the arcuate nucleus is a feeding center in which major peripheral energy signals are directly sensed and integrated. Furthermore, there are subpopulations of NPY neurons in regard to their responsiveness to peripheral signals. These findings suggest that NPY neuron in the arcuate nucleus is an essential feeding center to induce food intake in response to peripheral metabolic state. Copyright © 2012 Elsevier Ltd. All rights reserved.

  14. Techniques for calculations with nPI effective actions

    Directory of Open Access Journals (Sweden)

    Carrington M.E.

    2015-01-01

    Full Text Available We consider a symmetric scalar theory with quartic coupling in 2- and 3- dimensions and compare the self-consistent 4-point vertex obtained from the 4PI effective action with the Bethe-Salpeter 4-vertex from 2PI effective action. We show that when the coupling is large the contributions from the higher order effective action are large. We also show that one can solve the 2PI equations of motion in 4-dimensions, without introducing counter-terms, using a renormalization group method. This method provides a promising starting point to study the renormalization of higher order nPI theories.

  15. Origins of the many NPY-family receptors in mammals

    DEFF Research Database (Denmark)

    Larhammar, D; Wraith, A; Berglund, M M

    2001-01-01

    The NPY system has a multitude of effects and is particularly well known for its role in appetite regulation. We have found that the five presently known receptors in mammals arose very early in vertebrate evolution before the appearance of jawed vertebrates 400 million years ago. The genes Y(1), Y....... These observations pertain to the discussion whether ligands or receptors tend to appear first in evolution. The roles of Y(1) and Y(5) in feeding may differ between species demonstrating the importance of performing functional studies in additional mammals to mouse and rat....

  16. Structure and function of the amygdaloid NPY system: NPY Y2 receptors regulate excitatory and inhibitory synaptic transmission in the centromedial amygdala.

    Science.gov (United States)

    Wood, J; Verma, D; Lach, G; Bonaventure, P; Herzog, H; Sperk, G; Tasan, R O

    2016-09-01

    The amygdala is essential for generating emotional-affective behaviors. It consists of several nuclei with highly selective, elaborate functions. In particular, the central extended amygdala, consisting of the central amygdala (CEA) and the bed nucleus of the stria terminalis (BNST) is an essential component actively controlling efferent connections to downstream effectors like hypothalamus and brain stem. Both, CEA and BNST contain high amounts of different neuropeptides that significantly contribute to synaptic transmission. Among these, neuropeptide Y (NPY) has emerged as an important anxiolytic and fear-reducing neuromodulator. Here, we characterized the expression, connectivity and electrophysiological function of NPY and Y2 receptors within the CEA. We identified several NPY-expressing neuronal populations, including somatostatin- and calretinin-expressing neurons. Furthermore, in the main intercalated nucleus, NPY is expressed primarily in dopamine D1 receptor-expressing neurons but also in interspersed somatostatin-expressing neurons. Interestingly, NPY neurons did not co-localize with the Y2 receptor. Retrograde tract tracing experiments revealed that NPY neurons reciprocally connect the CEA and BNST. Functionally, the Y2 receptor agonist PYY3-36, reduced both, inhibitory as well as excitatory synaptic transmission in the centromedial amygdala (CEm). However, we also provide evidence that lack of NPY or Y2 receptors results in increased GABA release specifically at inhibitory synapses in the CEm. Taken together, our findings suggest that NPY expressed by distinct populations of neurons can modulate afferent and efferent projections of the CEA via presynaptic Y2 receptors located at inhibitory and excitatory synapses.

  17. Role of neuropeptide Y (NPY) in the regulation of reproduction: study based on catfish model.

    Science.gov (United States)

    Subhedar, Nishikant; Gaikwad, Archana; Biju, K C; Saha, Subhash

    2005-04-01

    Significance of NPY in the regulation of GnRH-LH axis was evaluated. Considerable NPY immunoreactivity was seen in the components like olfactory system, basal telencephalon, preoptic and tuberal areas, and the pituitary gland that serve as neuroanatomical substrates for processing reproductive information. Close anatomical association as well as colocalizations of NPY and GnRH were seen in the olfactory receptor neurons, olfactory nerve fibers and their terminals in the glomeruli, ganglion cells of nervus terminalis, medial olfactory tracts, fibers in the ventral telencephalon and pituitary. In the pituitary, NPY fibers seem to innervate the GnRH as well as LH cells. Intracranial administration of NPY resulted in significant increase in the GnRH immunoreactivity in all the components of the olfactory system. In the pituitary, NPY augmented the population of GnRH fibers and LH cells. HPLC analysis showed that salmon GnRH content in the olfactory organ, bulb, preoptic area+telencephalon and pituitary was also significantly increased following NPY treatment. NPY may play a role in positive regulation of GnRH throughout the neuraxis and also up-regulate the LH cells in the pituitary.

  18. NPY-leptin : opposing effects on appetitive and consummatory ingestive behavior and sexual behavior

    NARCIS (Netherlands)

    Ammar, AA; Sederholm, F; Saito, TR; Scheurink, AJW; Johnson, AE; Södersten, P.

    Many studies have indicated that neuropeptide Y (NPY) stimulates and leptin inhibits food intake. In line with this, intracerebroventricular injection of NPY (10 mu g) stimulated and leptin (10 mu g) inhibited intake of a sucrose solution when female rats were required to obtain the solution from a

  19. A small potassium current in AgRP/NPY neurons regulates feeding behavior and enery metabolism

    Science.gov (United States)

    Neurons that co-express agouti-related peptide (AgRP) and neuropeptide Y (NPY) are indispensable for normal feeding behavior. Firing activities of AgRP/NPY neurons are dynamically regulated by energy status and coordinate appropriate feeding behavior to meet nutritional demands. However, intrinsic m...

  20. Effects of NPY and the specific Y1 receptor agonist [D-His(26)]-NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats.

    Science.gov (United States)

    Rylkova, Daria; Boissoneault, Jeffrey; Isaac, Shani; Prado, Melissa; Shah, Hina P; Bruijnzeel, Adrie W

    2008-06-01

    Tobacco addiction is a chronic disorder that is characterized by dysphoria upon smoking cessation and relapse after periods of abstinence. Previous research suggests that Neuropeptide Y (NPY) and Y1 receptor agonists attenuate negative affective states and somatic withdrawal signs. The aim of the present experiments was to investigate the effects of NPY and the specific Y1 receptor agonist [D-His(26)]-NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats. The intracranial self-stimulation procedure was used to assess the effects of nicotine withdrawal on brain reward function as this procedure can provide a quantitative measure of emotional states in rodents. Elevations in brain reward thresholds are indicative of a deficit in brain reward function. In the first experiment, NPY did not prevent the elevations in brain reward thresholds associated with precipitated nicotine withdrawal and elevated the brain reward thresholds of the saline-treated control rats. Similar to NPY, [D-His(26)]-NPY did not prevent the elevations in brain reward thresholds associated with precipitated nicotine withdrawal and elevated the brain reward thresholds of the saline-treated control rats. Neither NPY nor [D-His(26)]-NPY affected the response latencies. In a separate experiment, it was demonstrated that the specific Y1 receptor antagonist BIBP-3226 prevented the NPY-induced elevations in brain reward thresholds. NPY attenuated the overall somatic signs associated with precipitated nicotine withdrawal. [D-His(26)]-NPY did not affect the overall somatic signs associated with precipitated nicotine withdrawal, but decreased the number of abdominal constrictions. Both NPY and [D-His(26)]-NPY attenuated the overall somatic signs associated with spontaneous nicotine withdrawal. These findings indicate that NPY and [D-His(26)]-NPY attenuate somatic nicotine withdrawal signs, but do not prevent the deficit in brain reward function associated

  1. Effect of Maluoning treatment on serum content of NPY in patients with COPD

    International Nuclear Information System (INIS)

    Wu Minghui; Jiang Anlai; Song Hedi

    2011-01-01

    Objective: To study the effect of maluoning treatment on serum NPY contents in patients with COPD. Methods: To COPD patients were divided into two groups: treatment group (n=40), control groups (n=30). Serum NPY contents were determined in two groups patients at 1d-3d before admission and one year later respectively. Results: The serum NPY level in two groups of COPD patients were not much different at admission(89.4±15.2) pg/ml vs (90.5±15.6) pg/ml (P>0.05). Serum NPY contents in 40 patients with Maluoning treatment after one year were apparently lower than those in the 30 patients without Maluoning treatment (72.9±13.8) pg/ml vs (81.8±14.6) pg/ml (P<0.05). Conclusion: Maluoning could markedly reduce the serum NPY content in patients with COPD. (authors)

  2. Novel role of NPY in neuroimmune interaction and lung growth after intrauterine growth restriction.

    Science.gov (United States)

    Thangaratnarajah, Chansutha; Dinger, Katharina; Vohlen, Christina; Klaudt, Christian; Nawabi, Jawed; Lopez Garcia, Eva; Kwapiszewska, Grazyna; Dobner, Julia; Nüsken, Kai D; van Koningsbruggen-Rietschel, Silke; von Hörsten, Stephan; Dötsch, Jörg; Alejandre Alcázar, Miguel A

    2017-09-01

    Individuals with intrauterine growth restriction (IUGR) are at risk for chronic lung disease. Using a rat model, we showed in our previous studies that altered lung structure is related to IL-6/STAT3 signaling. As neuropeptide Y (NPY), a coneurotransmitter of the sympathetic nervous system, regulates proliferation and immune response, we hypothesized that dysregulated NPY after IUGR is linked to IL-6, impaired myofibroblast function, and alveolar growth. IUGR was induced in rats by isocaloric low-protein diet; lungs were analyzed on embryonic day (E) 21, postnatal day (P) 3, P12, and P23. Finally, primary neonatal lung myofibroblasts (pnF) and murine embryonic fibroblasts (MEF) were used to assess proliferation, apoptosis, migration, and IL-6 expression. At E21, NPY and IL-6 expression was decreased, and AKT/PKC and STAT3/AMPKα signaling was reduced. Early reduction of NPY/IL-6 was associated with increased chord length in lungs after IUGR at P3, indicating reduced alveolar formation. At P23, however, IUGR rats exhibited a catch-up of body weight and alveolar growth coupled with more proliferating myofibroblasts. These structural findings after IUGR were linked to activated NPY/PKC, IL-6/AMPKα signaling. Complementary, IUGR-pnF showed increased survival, impaired migration, and reduced IL-6 compared with control-pnF (Co-pnF). In contrast, NPY induced proliferation, migration, and increased IL-6 synthesis in fibroblasts. Additionally, NPY -/- mice showed reduced IL-6 signaling and less proliferation of lung fibroblasts. Our study presents a novel role of NPY during alveolarization: NPY regulates 1 ) IL-6 and lung STAT3/AMPKα signaling, and 2 ) proliferation and migration of myofibroblasts. These new insights in pulmonary neuroimmune interaction offer potential strategies to enable lung growth. Copyright © 2017 the American Physiological Society.

  3. The Stimulatory Effect of Cerebral Intraventricular Injection of cNPY on Precocial Feeding Behavior in Neonatal Chicks (Gallus domesticus.

    Directory of Open Access Journals (Sweden)

    Guiqian Chen

    Full Text Available Neuropeptide Y (NPY is one of the most potent stimulants of food intake in many animals. Most of the supporting evidence for the effects of NPY has been gathered in mammalian species using porcine NPY. To investigate the effects of NPY on precocial feeding initiation in chicks, we firstly used chicken NPY (cNPY to study its role in food intake and spontaneous activities in 3-day-old male chicks. Food intake was monitored at different times after intracerebroventricular (ICV injection of cNPY (2.5, 5.0 or 10.0 μg/10 μL and anti-cNPY antibody (anti-cNPY (1:9000, 1:3000 or 1:1000 in dilution. cNPY given at different doses significantly increased food intake at 30 min, 60 min, 90 min and 120 min after injection. Chicks treated with 5.0 μg/10 μL of cNPY showed a maximal 4.48 fold increase in food intake comparing to the control at 30 min. There is still more than 2 fold increase in food intake at 120 min after injection of cNPY. Food intake was significantly inhibited by a single ICV injection of anti-cNPY diluted to 1:9000 (60% inhibition, 1:3000 (92% inhibition, and 1:1000 (95% inhibition at 30 min with 1:1000 being the maximally effective concentration. The inhibitory effects of anti-cNPY (diluted to1:9000, 1:3000, 1:1000 at 120 min post ICV injection were 22%, 42% and 46%, respectively. But ICV of anti-cNPY (1:3000 in dilution did not block the orexigenic effect of 2.5 μg/10 μL of cNPY. ICV injection of different concentrations of cNPY increases locomotor activity in a dose-dependent manner while ICV anti-cNPY greatly decreased the distance moved by each chick compared to control groups. Taken together, our results demonstrated that cNPY has a promoting effect on chick food intake and locomotor activity, and that endogenous cNPY might play a positive role in regulating precocial feeding behavior in newly hatched chicks.

  4. Clinical significance of determination of plasma ET and serum NSE, NPY levels in patients with Alzheimer diseases (AD)

    International Nuclear Information System (INIS)

    Song Hua

    2009-01-01

    Objective: To explore the clinical significance of changes of plasma ET and serum NSE, NPY levels in patients with Alzheimer diseases. Methods: Plasma ET and serum NSE, NPY levels were determined with RIA in 31 patients with Alzheimer diseases and 30 controls. Results: The plasma ET and serum NSE, NPY levels in the patients were significantly higher than those in controls (P<0.01). Plasma ET and serum NSE, NPY levels were mutually positively correlated (r=0.4895, 0.6014, P<0.01). Conclusion: Detection of plasma ET and serum NSE, NPY levels was helpful for the prediction of treatment effieacy in patients with Alzheimer diseases. (authors)

  5. Neuropeptide Y (NPY) and peptide YY (PYY) receptors in rat brain

    International Nuclear Information System (INIS)

    Ohkubo, T.; Niwa, M.; Yamashita, K.; Kataoka, Y.; Shigematsu, K.

    1990-01-01

    1. Specific binding sites for neuropeptide Y (NPY) and peptide YY (PYY) were investigated in rat brain areas using quantitative receptor autoradiography with 125 I-Bolton-Hunter NPY ( 125 I-BH-NPY) and 125 I-PYY, radioligands for PP-fold family peptides receptors. 2. There were no differences between localization of 125 I-BH-NPY and 125 I-PYY binding sites in the rat brain. High densities of the binding sites were present in the anterior olfactory nucleus, lateral septal nucleus, stratum radiatum of the hippocampus, posteromedial cortical amygdaloid nucleus, and area postrema. 3. In cold ligand-saturation experiments done in the presence of increasing concentrations of unlabeled NPY and PYY, 125 I-BH-NPY and 125 I-PYY binding to the stratum radiatum of the hippocampus, layer I of the somatosensory frontoparietal cortex, molecular layer of the cerebellum, and area postrema was single and of a high affinity. There was a significant difference between the affinities of 125 I-BH-NPY (Kd = 0.96 nM) and 125 I-PYY binding (Kd = 0.05 nM) to the molecular layer of the cerebellum. The binding of the two radioligands to the other areas examined had the same affinities. 4. When comparing the potency of unlabeled rat pancreatic polypeptide (rPP), a family peptide of NPY and PYY, to inhibit the binding to the areas examined, rPP displaced 125 I-BH-NPY and 125 I-PYY binding to the area postrema more potently than it did the binding to the stratum radiatum of the hippocampus, layer I of the somatosensory frontoparietal cortex, and molecular layer of the cerebellum. 5. Thus, the quantitative receptor autoradiographic method with 125 I-BH-NPY and 125 I-PYY revealed differences in binding characteristics of specific NPY and PYY binding sites in different areas of the rat brain. The results provide further evidence for the existence of multiple NPY-PYY receptors in the central nervous system

  6. Clinical significance of changes of plasma ET and NPY levels after treatment in patients with AMI

    International Nuclear Information System (INIS)

    Zhou Jinbao

    2005-01-01

    Objective: To investigate the changes of plasma ET and NPY levels in patients with AMI. Methods: Plasma ET and NPY levels were dynamically determined in 36 patients with AMI right after establishment of diagnosis and 8h, 24h, 4ph, 72h, 7d, 14d later. Levels in 35 healthy individuals were taken as control. Results: Before treatment was initiated, the levels of Et and Np in patients with AMI were significantly higher than those in controls (P <0.01). After one week of treatment, the levels dropped toward normal. Conclusion: Dynamic measurement of plasma ET and NPY levels in patients with AMI is of clinical importance. (authors)

  7. Quantitative Study of NPY-Expressing GABAergic Neurons and Axons in Rat Spinal Dorsal Horn*

    OpenAIRE

    Polg?r, Erika; Sardella, Thomas CP; Watanabe, Masahiko; Todd, Andrew J

    2010-01-01

    Between 25?40% of neurons in laminae I?III are GABAergic, and some of these express neuropeptide Y (NPY). We previously reported that NPY-immunoreactive axons form numerous synapses on lamina III projection neurons that possess the neurokinin 1 receptor (NK1r). The aims of this study were to determine the proportion of neurons and GABAergic boutons in this region that contain NPY, and to look for evidence that they selectively innervate different neuronal populations. We found that 4?6% of ne...

  8. Cross-cultural invariance of NPI-13: Entitlement as culturally specific, leadership and grandiosity as culturally universal.

    Science.gov (United States)

    Żemojtel-Piotrowska, Magdalena; Piotrowski, Jarosław; Rogoza, Radosław; Baran, Tomasz; Hitokoto, Hidefumi; Maltby, John

    2018-04-15

    The current study explores the problem with the lack of measurement invariance for the Narcissistic Personality Inventory (NPI) by addressing two issues: conceptual heterogeneity of narcissism and methodological issues related to the binary character of data. We examine the measurement invariance of the 13-item version of the NPI in three populations in Japan, Poland and the UK. Analyses revealed that leadership/authority and grandiose exhibitionism dimensions of the NPI were cross-culturally invariant, while entitlement/exploitativeness was culturally specific. Therefore, we proposed NPI-9 as indicating scalar invariance, and we examined the pattern of correlations between NPI-9 and other variables across three countries. The results suggest that NPI-9 is valid brief scale measuring general levels of narcissism in cross-cultural studies, while the NPI-13 remains suitable for research within specific countries. © 2018 International Union of Psychological Science.

  9. Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP.

    Science.gov (United States)

    Krashes, Michael J; Shah, Bhavik P; Koda, Shuichi; Lowell, Bradford B

    2013-10-01

    Agouti-related peptide (AgRP) neurons of the hypothalamus release a fast transmitter (GABA) in addition to neuropeptides (neuropeptide Y [NPY] and Agouti-related peptide [AgRP]). This raises questions as to their respective functions. The acute activation of AgRP neurons robustly promotes food intake, while central injections of AgRP, NPY, or GABA agonist results in the marked escalation of food consumption with temporal variance. Given the orexigenic capability of all three of these neuroactive substances in conjunction with their coexpression in AgRP neurons, we looked to unravel their relative temporal role in driving food intake. After the acute stimulation of AgRP neurons with DREADD technology, we found that either GABA or NPY is required for the rapid stimulation of feeding, and the neuropeptide AgRP, through action on MC4 receptors, is sufficient to induce feeding over a delayed yet prolonged period. These studies help to elucidate the neurochemical mechanisms of AgRP neurons in controlling temporally distinct phases of eating. Copyright © 2013 Elsevier Inc. All rights reserved.

  10. Polymorphism in NPY and IGF-I genes associate with reproductive ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-10-05

    Oct 5, 2009 ... effects of NPY and IGF-I genes on reproductive traits of chickens. Key words: ... flavor and good egg quality are accorded with Chinese consumers' taste. ... Numerous studies in mammals and more recently in teleost fish.

  11. Short-Term Prognostic Index for Breast Cancer: NPI or Lpi

    Directory of Open Access Journals (Sweden)

    V. Van Belle

    2011-01-01

    Full Text Available Axillary lymph node involvement is an important prognostic factor for breast cancer survival but is confounded by the number of nodes examined. We compare the performance of the log odds prognostic index (Lpi, using a ratio of the positive versus negative lymph nodes, with the Nottingham Prognostic Index (NPI for short-term breast cancer specific disease free survival. A total of 1818 operable breast cancer patients treated in the University Hospital of Leuven between 2000 and 2005 were included. The performance of the NPI and Lpi were compared on two levels: calibration and discrimination. The latter was evaluated using the concordance index (cindex, the number of patients in the extreme groups, and difference in event rates between these. The NPI had a significant higher cindex, but a significant lower percentage of patients in the extreme risk groups. After updating both indices, no significant differences between NPI and Lpi were noted.

  12. Identification of SNPs in NPY and LEP and the association with food ...

    Indian Academy of Sciences (India)

    gene can potentially affect the neuronal regulation of appetite and feeding behaviour in cattle ... in NPY. LEP is regulated by glucose after feeding (Mueller et al. 1998). .... cose metabolism regulates leptin secretion from cultured rat adipocytes.

  13. Hippocampal NPY gene transfer attenuates seizures without affecting epilepsy-induced impairment of LTP

    DEFF Research Database (Denmark)

    Sørensen, Andreas T; Nikitidou, Litsa; Ledri, Marco

    2009-01-01

    (TLE). However, our previous studies show that recombinant adeno-associated viral (rAAV)-NPY treatment in naive rats attenuates long-term potentiation (LTP) and transiently impairs hippocampal learning process, indicating that negative effect on memory function could be a potential side effect of NPY...... is significantly attenuated in vitro. Importantly, transgene NPY overexpression has no effect on short-term synaptic plasticity, and does not further compromise LTP in kindled animals. These data suggest that epileptic seizure-induced impairment of memory function in the hippocampus may not be further affected...... injected with rAAV-NPY, we show that rapid kindling-induced hippocampal seizures in vivo are effectively suppressed as compared to rAAV-empty injected (control) rats. Six to nine weeks later, basal synaptic transmission and short-term synaptic plasticity are unchanged after rapid kindling, while LTP...

  14. NPY gene transfer in the hippocampus attenuates synaptic plasticity and learning

    DEFF Research Database (Denmark)

    Sørensen, Andreas T; Kanter-Schlifke, Irene; Carli, Mirjana

    2008-01-01

    -mediated mechanisms. In addition, transgene NPY seems to be released during high frequency neuronal activity, leading to decreased glutamate release in excitatory synapses. Importantly, memory consolidation appears to be affected by the treatment. We found that long-term potentiation (LTP) in the CA1 area...... processing. Here we show, by electrophysiological recordings in CA1 of the hippocampal formation of rats, that hippocampal NPY gene transfer into the intact brain does not affect basal synaptic transmission, but slightly alters short-term synaptic plasticity, most likely via NPY Y2 receptor....... Future clinical progress, however, requires more detailed evaluation of possible side effects of this treatment. Until now it has been unknown whether rAAV vector-based NPY overexpression in the hippocampus alters normal synaptic transmission and plasticity, which could disturb learning and memory...

  15. Central and peripheral mechanisms of the NPY system in the regulation of bone and adipose tissue.

    Science.gov (United States)

    Shi, Yan-Chuan; Baldock, Paul A

    2012-02-01

    Skeletal research is currently undergoing a period of marked expansion. The boundaries of "bone" research are being re-evaluated and with this, a growing recognition of a more complex and interconnected biology than previously considered. One aspect that has become the focus of particular attention is the relationship between bone and fat homeostasis. Evidence from a number of avenues indicates that bone and adipose regulation are both related and interdependent. This review examines the neuropeptide Y (NPY) system, known to exert powerful control over both bone and fat tissue. The actions of this system are characterized by signaling both within specific nuclei of the hypothalamus and also the target tissues, mediated predominantly through two G-protein coupled receptors (Y1 and Y2). In bone tissue, elevated NPY levels act consistently to repress osteoblast activity. Moreover, both central Y2 receptor and osteoblastic Y1 receptor signaling act similarly to repress bone formation. Conversely, loss of NPY expression or receptor signaling induces increased osteoblast activity and bone mass in both cortical and cancellous envelopes. In fat tissue, NPY action is more complex. Energy homeostasis is powerfully altered by elevations in hypothalamic NPY, resulting in increases in fat accretion and body-wide energy conservation, through the action of locally expressed Y1 receptors, while local Y2 receptors act to inhibit NPY-ergic tone. Loss of central NPY expression has a markedly reduced effect, consistent with a physiological drive to promote fat accretion. In fat tissue, NPY and Y1 receptors act to promote lipogenesis, consistent with their roles in the brain. Y2 receptors expressed in adipocytes also act in this manner, showing an opposing action to their role in the hypothalamus. While direct investigation of these processes has yet to be completed, these responses appear to be interrelated to some degree. The starvation-based signal of elevated central NPY inducing

  16. Stress-related neuropeptides and alcoholism: CRH, NPY and beyond

    Science.gov (United States)

    Ciccocioppo, Roberto; Gehlert, Donald R.; Ryabinin, Andrey; Kaur, Simranjit; Cippitelli, Andrea; Thorsell, Annika; Lê, Anh D.; Hipskind, Philip A.; Hamdouchi, Chafiq; Lu, Jianliang; Hembre, Erik J.; Cramer, Jeffrey; Song, Min; McKinzie, David; Morin, Michelle; Economidou, Daina; Stopponi, Serena; Cannella, Nazzareno; Braconi, Simone; Kallupi, Marsida; de Guglielmo, Giordano; Massi, Maurizio; George, David T.; Gilman, Jody; Hersh, Jacqueline; Tauscher, Johannes T.; Hunt, Stephen P.; Hommer, Daniel; Heilig, Markus

    2009-01-01

    This article summarizes the proceedings of a symposium held at the conference on “Alcoholism and Stress: A Framework for Future Treatment Strategies” in Volterra, Italy, May 6–9, 2008. Chaired by Markus Heilig and Roberto Ciccocioppo, this symposium offered a forum for the presentation of recent data linking neuropetidergic neurotransmission to the regulation of different alcohol related behaviours in animals and in humans. Dr. Donald Gehlert described the development of a new corticotrophin releasing factor (CRH) receptor 1 antagonist and showed its efficacy in reducing alcohol consumption and stress-induced relapse in different animal models of alcohol abuse. Dr. Andrey Ryabinin reviewed recent findings in his laboratory indicating a role of the urocortin 1 (Ucn) receptor system in the regulation of alcohol intake. Dr. Annika Thorsell showed data supporting the significance of the neuropetide Y (NPY) receptor system in the modulation of behaviours associated with a history of ethanol intoxication. Dr. Roberto Ciccocioppo focused his presentation on the nociceptin/orphanin FQ (N/OFQ) receptors as treatment targets for alcoholism. Finally, Dr. Markus Heilig showed recent preclinical and clinical evidence suggesting that neurokinin 1 (NK1) antagonism may represent a promising new treatment for alcoholism. Collectively, these investigators highlighted the significance of neuropeptidergic neurotransmission in the regulation of neurobiological mechanisms of alcohol addiction. Data also revealed the importance of these systems as treatment targets for the development of new medication for alcoholism. PMID:19913192

  17. Gold nanoparticles production using reactor and cyclotron based methods in assessment of {sup 196,198}Au production yields by {sup 197}Au neutron absorption for therapeutic purposes

    Energy Technology Data Exchange (ETDEWEB)

    Khorshidi, Abdollah, E-mail: abkhorshidi@yahoo.com

    2016-11-01

    Medical nano-gold radioisotopes is produced regularly using high-flux nuclear reactors, and an accelerator-driven neutron activator can turn out higher yield of {sup 197}Au(n,γ){sup 196,198}Au reactions. Here, nano-gold production via radiative/neutron capture was investigated using irradiated Tehran Research Reactor flux and also simulated proton beam of Karaj cyclotron in Iran. {sup 197}Au nano-solution, including 20 nm shaped spherical gold and water, was irradiated under Tehran reactor flux at 2.5E + 13 n/cm{sup 2}/s for {sup 196,198}Au activity and production yield estimations. Meanwhile, the yield was examined using 30 MeV proton beam of Karaj cyclotron via simulated new neutron activator containing beryllium target, bismuth moderator around the target, and also PbF{sub 2} reflector enclosed the moderator region. Transmutation in {sup 197}Au nano-solution samples were explored at 15 and 25 cm distances from the target. The neutron flux behavior inside the water and bismuth moderators was investigated for nano-gold particles transmutation. The transport of fast neutrons inside bismuth material as heavy nuclei with a lesser lethargy can be contributed in enhanced nano-gold transmutation with long duration time than the water moderator in reactor-based method. Cyclotron-driven production of βeta-emitting radioisotopes for brachytherapy applications can complete the nano-gold production technology as a safer approach as compared to the reactor-based method. - Graphical abstract: This figure describes gold nanoparticles production via cyclotron based method. The aim of investigating is to estimate activity and saturation yield of {sup 197}Au(n,γ){sup 198}Au and {sup 197}Au(n,2n){sup 196}Au reactions using Karaj cyclotron available in Iran. The feasibility of a cyclotron-driven production of βeta-emitting radioisotopes was investigated for therapeutic applications via a new neutron activator design. - Highlights: • Nano-gold radioisotope production

  18. Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novel NPY-cleaving peptidases and potential drug interactions in CNS and Periphery.

    Science.gov (United States)

    Wagner, Leona; Wolf, Raik; Zeitschel, Ulrike; Rossner, Steffen; Petersén, Åsa; Leavitt, Blair R; Kästner, Florian; Rothermundt, Matthias; Gärtner, Ulf-Torsten; Gündel, Daniel; Schlenzig, Dagmar; Frerker, Nadine; Schade, Jutta; Manhart, Susanne; Rahfeld, Jens-Ulrich; Demuth, Hans-Ulrich; von Hörsten, Stephan

    2015-12-01

    The bioactivity of neuropeptide Y (NPY) is either N-terminally modulated with respect to receptor selectivity by dipeptidyl peptidase 4 (DP4)-like enzymes or proteolytic degraded by neprilysin or meprins, thereby abrogating signal transduction. However, neither the subcellular nor the compartmental differentiation of these regulatory mechanisms is fully understood. Using mass spectrometry, selective inhibitors and histochemistry, studies across various cell types, body fluids, and tissues revealed that most frequently DP4-like enzymes, aminopeptidases P, secreted meprin-A (Mep-A), and cathepsin D (CTSD) rapidly hydrolyze NPY, depending on the cell type and tissue under study. Novel degradation of NPY by cathepsins B, D, L, G, S, and tissue kallikrein could also be identified. The expression of DP4, CTSD, and Mep-A at the median eminence indicates that the bioactivity of NPY is regulated by peptidases at the interphase between the periphery and the CNS. Detailed ex vivo studies on human sera and CSF samples recognized CTSD as the major NPY-cleaving enzyme in the CSF, whereas an additional C-terminal truncation by angiotensin-converting enzyme could be detected in serum. The latter finding hints to potential drug interaction between antidiabetic DP4 inhibitors and anti-hypertensive angiotensin-converting enzyme inhibitors, while it ablates suspected hypertensive side effects of only antidiabetic DP4-inhibitors application. The bioactivity of neuropeptide Y (NPY) is either N-terminally modulated with respect to receptor selectivity by dipeptidyl peptidase 4 (DP4)-like enzymes or proteolytic degraded by neprilysin or meprins, thereby abrogating signal transduction. However, neither the subcellular nor the compartmental differentiation of these regulatory mechanisms is fully understood. Using mass spectrometry, selective inhibitors and histochemistry, studies across various cell types, body fluids, and tissues revealed that most frequently DP4-like enzymes

  19. Dependency-dependent interference: NPI interference, agreement attraction, and global pragmatic inferences

    Directory of Open Access Journals (Sweden)

    Ming eXiang

    2013-10-01

    Full Text Available Previous psycholinguistics studies have shown that when forming a long distance dependency in online processing, the parser sometimes accepts a sentence even though the required grammatical constraints are only partially met. A mechanistic account of how such errors arise sheds light on both the underlying linguistic representations involved and the processing mechanisms that put such representations together. In the current study, we contrast the NPI (negative polarity items interference effect, as shown by the acceptance of an ungrammatical sentence like The bills that democratic senators have voted for will ever become law, with the well-known phenomenon of agreement attraction (The key to the cabinets are…. On the surface, these two types of errors look alike and thereby can be explained as being driven by the same source: similarity based memory interference. However, we argue that the linguistic representations involved in NPI licensing are substantially different from those of subject-verb agreement, and therefore the interference effects in each domain potentially arise from distinct sources. In particular, we show that NPI interference at least partially arises from pragmatic inferences. In a self-paced reading study with an acceptability judgment task, we showed NPI interference was modulated by participants’ general pragmatic communicative skills, as quantified by the Autism-Spectrum Quotient (Baron-Cohen 2001, especially in offline tasks. Participants with more autistic traits were actually less prone to the NPI interference effect than those with fewer autistic traits. This result contrasted with agreement attraction conditions, which were not influenced by individual pragmatic skill differences. We also show that different NPI licensors have distinct interference profiles. We discuss two kinds of interference effects for NPI licensing: memory-retrieval based and pragmatically triggered.

  20. NPY intraperitoneal injections produce antidepressant-like effects and downregulate BDNF in the rat hypothalamus.

    Science.gov (United States)

    Gelfo, Francesca; Tirassa, Paola; De Bartolo, Paola; Croce, Nicoletta; Bernardini, Sergio; Caltagirone, Carlo; Petrosini, Laura; Angelucci, Francesco

    2012-06-01

    Several studies have documented an involvement of Neuropeptide Y (NPY) in stress-related disorders. Stress-related disorders are also characterized by changes in brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), neurotrophins implicated in the survival and function of neurons. Thus the aim of this study was to investigate whether an NPY intraperitoneal treatment has antidepressant-like effects in rats subjected to a classical stress paradigm, the Forced Swim Test (FST), in association with changes in local brain neurotrophin production. Rats were intraperitoneally injected with either NPY (60 μg/kg) or a vehicle for three consecutive days between two FST sessions and then tested for time spent (or delay onset) in immobile posture. Moreover, we measured by enzyme-linked immunosorbent assay (ELISA) neurotrophin levels in the hypothalamus and corticosterone levels in plasma. The data showed that NPY induced a significant delay in the onset and a significant reduction in the duration of the immobility posture in FST. We also found that NPY decreased BDNF levels in the hypothalamus and corticosterone levels in plasma. Immobility posture in FST can be reduced by antidepressant drugs. Thus, our data show an antidepressant-like effect of NPY associated with changes in BDNF levels in the hypothalamus and reduced activity of hypothalamic-pituitary-adrenal (HPA) axis. These findings, while confirming the involvement of the NPY system in stress-related disorders, suggest that a less invasive route of administration, such as an intraperitoneal injection, may be instrumental in coping with stressful events in animal models and perhaps in humans. © 2012 Blackwell Publishing Ltd.

  1. Comparison of a high-carbohydrate and high-protein breakfast effect on plasma ghrelin, obestatin, NPY and PYY levels in women with anorexia and bulimia nervosa

    Directory of Open Access Journals (Sweden)

    Sedlackova Dana

    2012-06-01

    Full Text Available Abstract Background The present study investigated plasma levels of gut-brain axis peptides ghrelin, obestatin, NPY and PYY after consumption of a high-carbohydrate (HC and high-protein (HP breakfast in patients with anorexia nervosa, bulimia nervosa and in healthy controls. These peptides play an important role in regulation of energy homeostasis and their secretion is disturbed under condition of eating disorders. As various types of consumed macronutrients may induce different plasma hormone responses, so we examined these responses in women patients with eating disorders and compared them with those of healthy controls. Methods We examined plasma hormone responses to HC and HP breakfast in patients with AN (n = 14; age: 24.6 ± 1.8 years, BMI: 15.3 ± 0.7, BN (n = 15; age: 23.2 ± 1.7 years, BMI: 20.5 ± 0.9 and healthy controls (n = 14; age: 24.9 ± 1.4 years, BMI: 21.1 ± 0.8. Blood samples were drawn from the cubital vein, the first blood drawn was collected before meal, and then 30, 60, 90, 120 and 150 min after breakfast consumption. Plasma hormone levels were determined by commercially available RIA kits. Results Fasting and postprandial plasma obestatin levels were significantly increased in both AN and BN patients, while plasma ghrelin levels were significantly increased in AN patients only. After breakfast consumption, plasma levels of ghrelin and obestatin decreased, although they were still above the range of values of healthy controls. Fasting NPY plasma levels were significantly increased in AN and BN patients and did not change postprandially. Fasting PYY levels were comparable in AN, BN and healthy controls, but postprandially significantly increased after HP breakfast in AN and BN patients. Different reactions to breakfast consumption was found for ghrelin and PYY among investigated groups, while for obestatin and NPY these reactions were similar in all groups. Conclusions Significant

  2. Clinical significance of determination of plasma NPY levels and serum lipid profile in patients with cerebral hemorrhage and cerebral infarction

    International Nuclear Information System (INIS)

    Huang Fujuan; Shen Airong; Yang Yongqing

    2010-01-01

    Objective: To study the clinical significance of changes of plasma NPY levels and serum lipid profile in patients with cerebral hemorrhage and cerebral infarction. Methods: Plasma NPY levels (with RIA) and serum lipid profile (with biochemistry) were determined in (1) 48 patients with acute cerebral hemorrhage (2) 46 patients with acute cerebral infarction and (3) controls.Results Plasma NPY levels in both patients with cerebral hemorrhage and patients with cerebral infarction were significantly higher than those in controls (P 0.05). Conclusion: NPY played important roles in the development and pathogenesis of cerebral vascular accidents. Lipid profile changes was the basic etiological factor. (authors)

  3. The clinical application of determination of plasma NPY levels for diagnosis and treatment of cardiovascular diseases

    International Nuclear Information System (INIS)

    Zheng Qing; Bao Yimin; Yang Yongqing

    2010-01-01

    Objective: To study the clinical usefulness of determination of plasma NPY levels for diagnosis and treatment of cardiovascular disease. Methods: Plasma levels of NPY were determined with RIA in 180 patients with heart failure from CHD, 89 patients with AMI, 58 patients with essential hypertension, 109 patients with PIH and 47 controls. Results: The plasma levels of NPY in 180 patients with heart failure were 206.37±40.1 pg/ml (I grade, P<0.05), 218.62±64.83 pg/ml (II grade, P<0.05), 269.16±56.57 pg/ml (III grade, P<0.01) and 314.82±56.73 pg/ml (IV grade, P<0.001), respectively. The plasma levels were 345.12±68.71 pg/ml and 191.46±38.92 pg/ml in patients with AMI and hypertension as a whole, respectively. All these levels were significantly higher than those in controls (P<0.05∼0.001). Among the patients, the plasma NPY levels increased along with advance of the disease process. Conclusion: Plasma NPY level was a useful marker for diagnosis and treatment of cardiovascular diseases. (authors)

  4. Alteration of NPY and Y1 receptor in dorsomedial and ventromedial areas of hypothalamus in anorectic tumor-bearing rats.

    Science.gov (United States)

    Chance, William T; Xiao, Chun; Dayal, Ramesh; Sheriff, Sulaiman

    2007-02-01

    Although previous studies have implicated NPY in the etiology of experimental cancer anorexia, the results have been difficult to interpret. Studies have suggested that although NPY level and message were decreased in the dorsomedial hypothalamic area (DMA), they were elevated in the ventromedial hypothalamic area (VMA). To better assess specific intra-area alterations of NPY, Y(1) receptor (Y(1) R), and agouti-related peptide (AgRP) in TB rats, we used radioimmunoassay, quantitative real-time RT-PCR, and immunohistochemistry. We found that NPY and AgRP mRNA were elevated significantly in whole hypothalamus of anorectic TB rats, while Y(1) R mRNA was decreased. Based on two replicates of four pooled samples each, both NPY and AgRP mRNA appeared to be elevated in the VMA of anorectic TB rats, while only AgRP exhibited a similar increase in the DMA. Levels of NPY were elevated in the VMA of both TB and pair-fed (PF) rats, but in the DMA only PF rats exhibited a significant NPY increase. NPY and Y(1) R immunohistochemistry revealed reduced NPY staining in PVN and ARC nucleus of TB and PF rats. Y(1) R immunostaining was also reduced in the ARC and PVN of TB rats, while PF rats exhibited elevated immunostaining in the PVN. These results continue to implicate dysfunction of NPY feeding systems in experimental cancer anorexia and suggest down-regulation of Y(1) R receptors as well as possible problems in NPY translation.

  5. [Cyclotron based nuclear science

    International Nuclear Information System (INIS)

    1993-07-01

    The period 1 April 1992--31 March 1993 saw the initial runs of three new spectrometers, which constitute a major portion of the new detection capabilities developed for this facility. These devices are the Proton Spectrometer (PSP) (data from which are shown on the cover of this document), the Mass Achroniat Recoil Mass Spectrometer (MARS), and the Multipole Dipole Multipole (MDM) Particle Spectrometer. The ECR-K500 cyclotron combination operated 5,849 hours. The beam was on target 39% of this time. Studies of nuclear dynamics and nuclear thermodynamics using the neutron ball have come to fruition. A critical re-evaluation of the available data on the giant monopole resonance indicated that the incompressibility is not specified to a range smaller than 200--350 MeV by those data. New systematic experiments using the MDM spectrometer are now underway. The MEGA collaboration obtained the first data on the μ → eγ decay rate and determination of the Michel parameter in normal μ decay. Experiments appear to confirm the existence of monoenergetic pair peaks even for relatively low Z projectile -- Z target combinations. Studies of the (α,2α) knockout reaction indicate that this reaction may prove to be a valuable tool for determination of reaction rates of astrophysical interest. Theoretical work reported in this document ranges from nuclear structure calculations using the IBM-2 model to calculations of kaon production and the in-medium properties of the rho and phi mesons. Nuclear dynamics and exotic shapes and fragmentation modes of hot nuclei are also addressed. New measurements of x-ray emission from highly ionized ions, of molecular dissociation and of surface interactions are reported. The research is presented in nearly 50 brief summaries usually including data and references

  6. [Cyclotron based nuclear science

    International Nuclear Information System (INIS)

    1991-08-01

    This report contains descriptions of research programs carried out by Institute staff, as well as progress on new instrumentation during the period, April 1, 1990, to March 31, 1991. The K500 cyclotron and ECR source provided beam for 4140 hours during the period. The beam was actually available for experiments 1927.50 hours and 1110.50 hours was devoted to developing new beams and exploring cyclotron performance. A wide range of beams from protons to Xe with energies from 2.4 MeV/u to 60 MeV/U have been used in experiments. The highest total energy beam accelerated was 35 MeV/u 63 Cu. The ECR source, made a tremendous improvement in accelerator performance and reliability. Substantial amounts of beam time were devoted to investigations of hot nuclei, electron-positron, giant resonances, atomic effects of high velocity ion beams, astrophysics related reactions and proton and alpha bremsstrahlung. Scientific accomplishments included determination of the heat capacity of nuclei through new insight into the level densities and establishing a lower limit for electron positron resonances a factor of ten better than previous measurements. The proton spectrometer, constructed for studies of the Gamow-Teller interaction is complete, and initial physics measurements will be made in the next few months. All of the BaF 2 crystals have been delivered and acceptance tests are underway. A K=315 MDM spectrometer has been obtained from Oxford University and is scheduled for installation in Spring 1992, after removal of the K=150 Enge split pole spectrometer. Institute groups continue participation in MEGA, instrumentation projects for RHIC, and few nucleon studies at LAMPF and KEK. Reports of these activities are included

  7. [Cyclotron based nuclear science

    International Nuclear Information System (INIS)

    1989-06-01

    This report contains papers on the following topics: Heavy ion reactors, nuclear structure and fundamental interactions; atomic and materials studies; nuclear theory; and superconducting cyclotron and instrumentation

  8. Neutron thermalization in reactor lattice cells: An NPY-project report

    International Nuclear Information System (INIS)

    Stamm'ler, R.J.J.; Takac, S.M.; Weiss, Z.J.

    1966-01-01

    The NPY-Project is a joint research programme in reactor physics between Norway, Poland, Yugoslavia and the International Atomic Energy Agency. One of the tasks of the project was to make a theoretical and experimental investigation of the phenomena of neutron thermalization in lattice cells, and this work is covered by the present monograph. The different lattices of the zero-power assemblies in the NPY countries offered ample opportunity for the theoreticians and experimentalists to test and compare their methods, and the exchange of experiences was stimulating and valuable. 85 refs, 26 figs, 19 tabs

  9. Clinical study on the changes of plasma Hcy, β2-m, cortisol, NPY levels and NPY contents in CSF in patients with acute traumatic intracranial hemorrhage as well as patients with cerebral infarction

    International Nuclear Information System (INIS)

    Ruan Wenhua; Yang Yongqing

    2007-01-01

    Objective: To invest/gate the clinical significance of the changes of plasma Hcy, β 2 -m, cortisol, NPY levels and NPY contents in CSF in patients with acute traumatic intracranial hemorrhage as well as patients with cerebral infarction. Methods: Plasma β 2 -m, cortisol, NPY, NPY in CSF (with RIA) and plasma Hey (with CLIA ) contents were measured in 68 patients with acute traumatic intracranial haemorrhage (mild 33, severe 35) as well as 39 patients with cerebral infarction (plus 35 controls). Results: The plasma β 2 -m, Hcy and 8h, 24h cortisol levels in all these patients were significantly higher than those in controls (P 2 -m, Hcy, cortisol levels and NPY contents in CSF were very prominent in all these patients studied. (authors)

  10. Enhanced Y1-receptor-mediated vasoconstrictive action of neuropeptide Y (NPY) in superior mesenteric arteries in portal hypertension.

    Science.gov (United States)

    Wiest, Reiner; Jurzik, Lars; Moleda, Lukas; Froh, Matthias; Schnabl, Bernd; von Hörsten, Stephan; Schölmerich, Juergen; Straub, Rainer H

    2006-03-01

    Vascular hyporeactivity to catecholamines contributes to arterial vasodilation and hemodynamic dysregulation in portal hypertension. Neuropeptide Y (NPY) is a sympathetic neurotransmitter facilitating adrenergic vasoconstriction via Y1-receptors on the vascular smooth muscle. Therefore, we investigated its role for vascular reactivity in the superior mesenteric artery (SMA) of portal vein ligated (PVL) and sham operated rats. In vitro perfused SMA vascular beds of rats were tested for the cumulative dose-response to NPY dependent on the presence and level of alpha1-adrenergic vascular tone (methoxamine MT: 0.3-10 microM). Moreover, the effect of NPY (50 nM) on vascular responsiveness to alpha1-adrenergic stimulation (MT: 0.3-300 microM) was evaluated. Y1-receptor function was tested by Y1-selective inhibition using BIBP-3226 (1 microM). NPY dose-dependently and endothelium-independently enhanced MT-pre-constriction in SMA. This potentiation was increasingly effective with increasing adrenergic pre-stimulation and being more pronounced in PVL rats as compared to sham rats at high MT concentrations. NPY enhanced vascular contractility only in PVL rats correcting the adrenergic vascular hyporeactivity. Y1-receptor inhibition completely abolished NPY-evoked vasoconstrictive effects. NPY endothelium-independently potentiates adrenergic vasoconstriction via Y1-receptors being more pronounced in portal hypertension improving mesenteric vascular contractility and thereby correcting the splanchnic vascular hyporeactivity. This makes NPY a superior vasoconstrictor counterbalancing arterial vasodilation in portal hypertension.

  11. Correlations of serum levels of leptin and other related factor (NPY, ADP) in female children with simple obesity

    International Nuclear Information System (INIS)

    Bai Hua; Wei Chunlei; Qian Mingzhu

    2008-01-01

    Objective: To study the changes of serum levels of leptin, NPY and ADP in female children with simple obesity. Methods: Serum levels of leptin, NPY and ADP were measured with radioimmunoassay (RIA) in 32 female children with simple obesity and 35 controls. Results: The serum levels of leptin, NPY were significantly higher in the obese children than those in controls (P<0.01), while the serum levels of ADP were significantly lower (P<0.01). Serum leptin levels were significantly positively correlated (r=0.6014, P<0.01) with NPY levels but were negatively correlated (r=-0.4786, P<0.01) with adiponectin (ADP) levels. Conclusion: Determination of serum leptin, NPY and ADP levels is of help for judgement of degree of obesity as wen as outcome prediction in female children. (authors)

  12. Activity-dependent volume transmission by transgene NPY attenuates glutamate release and LTP in the subiculum

    DEFF Research Database (Denmark)

    Sørensen, Andreas T; Kanter-Schlifke, Irene; Lin, En-Ju D

    2008-01-01

    Neuropeptide Y (NPY) gene transduction of the brain using viral vectors in epileptogenic regions can effectively suppress seizures in animals, and is being considered as a promising alternative treatment strategy for epilepsy. Therefore, it is fundamental to understand the detailed mechanisms...

  13. Bone Injury and Repair Trigger Central and Peripheral NPY Neuronal Pathways.

    Directory of Open Access Journals (Sweden)

    Cecília J Alves

    Full Text Available Bone repair is a specialized type of wound repair controlled by complex multi-factorial events. The nervous system is recognized as one of the key regulators of bone mass, thereby suggesting a role for neuronal pathways in bone homeostasis. However, in the context of bone injury and repair, little is known on the interplay between the nervous system and bone. Here, we addressed the neuropeptide Y (NPY neuronal arm during the initial stages of bone repair encompassing the inflammatory response and ossification phases in femoral-defect mouse model. Spatial and temporal analysis of transcriptional and protein levels of NPY and its receptors, Y1R and Y2R, reported to be involved in bone homeostasis, was performed in bone, dorsal root ganglia (DRG and hypothalamus after femoral injury. The results showed that NPY system activity is increased in a time- and space-dependent manner during bone repair. Y1R expression was trigged in both bone and DRG throughout the inflammatory phase, while a Y2R response was restricted to the hypothalamus and at a later stage, during the ossification step. Our results provide new insights into the involvement of NPY neuronal pathways in bone repair.

  14. Application of RIA of PRA, AT II and NPY in typing and therapy of EH patients

    International Nuclear Information System (INIS)

    Yang Yongqing; Wang Xiaozhou; Jiang Qinian

    2001-01-01

    Objective: To study the typing and AT II receptor inhibitor therapy for essential hypertension (EH) patients. Methods: Plasma RA, AT II and NPY levels were measured by radioimmunoassay (RIA) in 208 Patients with EH and 100 controls; plasma NPY levels were measured in 40 EH patients before and after AT II receptor inhibitor therapy. The mean coefficient of variation for intra and inter batch-assay were less than 10% and 15% respectively. Results: In 208 EH patients plasma PRA levels were increased, normal and decreased in 17.8%, 71.6% and 10.6% respectively, while in 128 EH patients Plasma AT II levels were increased, normal and decreased in 20.3%, 64.1% and 15.6% respectively. In 69 EH Plasma NPY levels were significantly higher than those in 40 control subjects. (17 grade I EH, 137.3 +- 32.6 pg/mL; 28 grade II EH, 148.5 +- 41.1 pg/mL; 24 grade III EH, 162.4 +- 42.7 pg/mL; 40 controls, 118.5 +- 30.5 pg/mL). In 40 EH patients plasma NPY levels were decreased after AT II receptor inhibitor therapy as the blood pressure decreased. Conclusion: Typing of EH patients according to levels of plasma PRA and AT II is useful in guiding treatment. AT II receptor inhibitors are indicated in those patients with increased plasma levels and NPY levels can be used for appraisal of the treatment efficacy

  15. Neuropeptide Y deficiency attenuates responses to fasting and high-fat diet in obesity-prone mice.

    Science.gov (United States)

    Patel, Hiralben R; Qi, Yong; Hawkins, Evan J; Hileman, Stanley M; Elmquist, Joel K; Imai, Yumi; Ahima, Rexford S

    2006-11-01

    Neuropeptide Y (NPY) stimulates feeding and weight gain, but deletion of the NPY gene does not affect food intake and body weight in mice bred on a mixed genetic background. We reasoned that the orexigenic action of NPY would be evident in C57Bl/6J mice susceptible to obesity. NPY deficiency has no significant effect in mice fed a normal rodent diet. However, energy expenditure is elevated during fasting, and hyperphagia and weight gain are blunted during refeeding. Expression of agouti-related peptide (AGRP) in the hypothalamus is increased in NPY knockout (NPYko) than wild-type mice, but unlike wild type there is no further increase in AGRP when NPYko mice are fasted. Moreover, NPYko mice have higher oxygen consumption and uncoupling protein-1 expression in brown adipose tissue during fasting. The failure of an increase in orexigenic peptides and higher thermogenesis may contribute to attenuation of weight gain when NPYko mice are refed. C57Bl/6J mice lacking NPY are also less susceptible to diet-induced obesity (DIO) as a result of reduced feeding and increased energy expenditure. The resistance to DIO in NPYko mice is associated with a reduction in nocturnal feeding and increased expression of anorexigenic hypothalamic peptides. Insulin, leptin, and triglyceride levels increase with adiposity in both wild-type and NPYko mice.

  16. Appetitive and consummatory ingestive behavior : Role of taste, dopamine and NPY

    OpenAIRE

    Sederholm, Fredrik

    2001-01-01

    The present thesis has examined the role of taste, dopamine and neuropeptide Y (NPY) in the regulation of the two phases of ingestive behavior: appetitive (approaching and handling of food) and consummatory ingestive behavior (chewing and swallowing). Behavioral studies were performed in male and female rats. THE ROLE OF TASTE: Background. A sweet stimulus loses its pleasantness to humans preloaded with glucose, but not if the subjects are food deprived. Thus, physiologi...

  17. Role of PPARα in the Control of Torpor through FGF21-NPY Pathway: From Circadian Clock to Seasonal Change in Mammals

    Directory of Open Access Journals (Sweden)

    Norio Ishida

    2009-01-01

    Full Text Available In nature, hibernating animals encounter fasting, cold temperature and short day seasonally. Torpor is a state of decreased physiological activity in an animal, usually characterized by a reduced body temperature and rate of metabolism to adapt such a severe environment. Ablation of the central clock synchronizer, the suprachiasmatic nucleus in brain, abolishes torpor, a hibernation-like state, implicating the circadian clock involved in this seasonal change. Biologists knows well the energy source of daily heterotherms/hibernators changed from glucose to lipids in winter. Here we review several lines of evidence of a master transcriptional regulator in lipid catabolism, PPARα, in the control of torpor through FGF21-NPY pathway. This indicate the importance of circadian—and photoperiod—regulation of PPARα to tell seasons in our body.

  18. The neuropeptides CCK and NPY and the changing view of cell-to-cell communication in the taste bud.

    Science.gov (United States)

    Herness, Scott; Zhao, Fang-Li

    2009-07-14

    The evolving view of the taste bud increasingly suggests that it operates as a complex signal processing unit. A number of neurotransmitters and neuropeptides and their corresponding receptors are now known to be expressed in subsets of taste receptor cells in the mammalian bud. These expression patterns set up hard-wired cell-to-cell communication pathways whose exact physiological roles still remain obscure. As occurs in other cellular systems, it is likely that neuropeptides are co-expressed with neurotransmitters and function as neuromodulators. Several neuropeptides have been identified in taste receptor cells including cholecystokinin (CCK), neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), and glucagon-like peptide 1 (GLP-1). Of these, CCK and NPY are the best studied. These two peptides are co-expressed in the same presynaptic cells; however, their postsynaptic actions are both divergent and antagonistic. CCK and its receptor, the CCK-1 subtype, are expressed in the same subset of taste receptor cells and the autocrine activation of these cells produces a number of excitatory physiological actions. Further, most of these cells are responsive to bitter stimuli. On the other hand, NPY and its receptor, the NPY-1 subtype, are expressed in different cells. NPY, acting in a paracrine fashion on NPY-1 receptors, results in inhibitory actions on the cell. Preliminary evidence suggests the NPY-1 receptor expressing cell co-expresses T1R3, a member of the T1R family of G-protein coupled receptors thought to be important in detection of sweet and umami stimuli. Thus the neuropeptide expressing cells co-express CCK, NPY, and CCK-1 receptor. Neuropeptides released from these cells during bitter stimulation may work in concert to both modulate the excitation of bitter-sensitive taste receptor cells while concurrently inhibiting sweet-sensitive cells. This modulatory process is similar to the phenomenon of lateral inhibition that occurs in other sensory systems.

  19. Promotional Model: A New Direction for National Program in Immunization (NPI) and Oral Rehydration Therapy (ORT) in Nigeria

    OpenAIRE

    P.EKERETE, Paulinus

    2000-01-01

    The National Program on Immunization (NPI), formerly known as the Expanded Program on Immunization (EPI) and Oral Rehydration Therapy (ORT), were relaunched in1984 after the problems of vaccine supply have been corrected. The NPI aimed to protect children against six childhood killer disease and ORT, to remedy dehydration. In order to achieve these objectives, Partner-in-Health strategy was set up to educate, convince and motivate mothers, pregnant women and community to accept the programme....

  20. @OceanSeaIceNPI: Positive Practice of Science Outreach via Social Media

    Science.gov (United States)

    Meyer, A.; Pavlov, A.; Rösel, A.; Granskog, M. A.; Gerland, S.; Hudson, S. R.; King, J.; Itkin, P.; Negrel, J.; Cohen, L.; Dodd, P. A.; de Steur, L.

    2016-12-01

    As researchers, we are keen to share our passion for science with the general public. We are encouraged to do so by colleagues, journalists, policy-makers and funding agencies. How can we best achieve this in a small research group without having specific resources and skills such as funding, dedicated staff, and training? How do we sustain communication on a regular basis as opposed to the limited lifetime of a specific project? The emerging platforms of social media have become powerful and inexpensive tools to communicate science for various audiences. Many research institutions and individual researchers are already advanced users of social media, but small research groups and labs remain underrepresented. A small group of oceanographers, sea ice, and atmospheric scientists at the Norwegian Polar Institute have been running their social media science outreach for two years @OceanSeaIceNPI. Here we share our successful experience of developing and maintaining a researcher-driven outreach through Instagram, Twitter and Facebook. We present our framework for sharing responsibilities within the group to maximize effectiveness. Each media channel has a target audience for which the posts are tailored. Collaboration with other online organizations and institutes is key for the growth of the channels. The @OceanSeaIceNPI posts reach more than 4000 followers on a weekly basis. If you have questions about our @OceanSeaIceNPI initiative, you can tweet them with a #ask_oceanseaicenpi hashtag anytime.

  1. Relationship between BMI and depression, according to the rs16139NPY gene

    Directory of Open Access Journals (Sweden)

    Hamideh Pishva

    2017-06-01

    Full Text Available Objective: obesity and depression are likely to interact mutually which makes it unclear if obesity causes depression or it leads to obesity; and how the genotypes have a role in obesity and depression.Methods and Materials: This cross sectional study was conducted on a sample of 400 individuals from the participants in the third phase of the comprehensive Iranian Multicenter Osteoporosis Study (IMOS. Anthropometric measurements and depression were assessed. To investigate the NPY polymorphism, PCR-RFLP was used. Binary logistic regression model was employed to determine depression as the dependent factor and gene polymorphismResults: the frequency of NPY rs16139 was 6%. No significant association could be found between NPY genotypes and depression (p >0.05. Furthermore, the results suggest that those with central obesity seem an increased chance of developing depression (P=0.02.Conclusion: There is a significant relationship between obesity and depression and obesity is a possible cause of depression. Waist circumference and abdominal obesity as components of metabolic syndrome have the most important effects on depression.

  2. Leptin, NPY, Melatonin and Zinc Levels in Experimental Hypothyroidism and Hyperthyroidism: The Relation to Zinc.

    Science.gov (United States)

    Baltaci, Abdulkerim Kasım; Mogulkoc, Rasim

    2017-06-01

    Since zinc mediates the effects of many hormones or is found in the structure of numerous hormone receptors, zinc deficiency leads to various functional impairments in the hormone balance. And also thyroid hormones have important activity on metabolism and feeding. NPY and leptin are affective on food intake and regulation of appetite. The present study is conducted to determine how zinc supplementation and deficiency affect thyroid hormones (free and total T3 and T4), melatonin, leptin, and NPY levels in thyroid dysfunction in rats. The experiment groups in the study were formed as follows: Control (C); Hypothyroidism (PTU); Hypothyroidism+Zinc (PTU+Zn); Hypothyroidism+Zinc deficient; Hyperthyroidism (H); Hyperthyroidism+Zinc (H+Zn); and Hyperthyroidism+Zinc deficient. Thyroid hormone parameters (FT 3 , FT 4 , TT 3 , and TT 4 ) were found to be reduced in hypothyroidism groups and elevated in the hyperthyroidism groups. Melatonin values increased in hyperthyroidism and decreased in hypothyroidism. Leptin and NPY levels both increased in hypo- and hyperthyroidism. Zinc levels, on the other hand, decreased in hypothyroidism and increased in hyperthyroidism. Zinc supplementation, particularly when thyroid function is impaired, has been demonstrated to markedly prevent these changes.

  3. Diet-induced obesity attenuates fasting-induced hyperphagia.

    Science.gov (United States)

    Briggs, D I; Lemus, M B; Kua, E; Andrews, Z B

    2011-07-01

    Obesity impairs arcuate (ARC) neuropeptide Y (NPY)/agouti-releated peptide (AgRP) neuronal function and renders these homeostatic neurones unresponsive to the orexigenic hormone ghrelin. In the present study, we investigated the effect of diet-induced obesity (DIO) on feeding behaviour, ARC neuronal activation and mRNA expression following another orexigenic stimulus, an overnight fast. We show that 9 weeks of high-fat feeding attenuates fasting-induced hyperphagia by suppressing ARC neuronal activation and hypothalamic NPY/AgRP mRNA expression. Thus, the lack of appropriate feeding responses in DIO mice to a fast is caused by failure ARC neurones to recognise and/or respond to orexigenic cues. We propose that fasting-induced hyperphagia is regulated not by homeostatic control of appetite in DIO mice, but rather by changes in the reward circuitry. © 2011 The Authors. Journal of Neuroendocrinology © 2011 Blackwell Publishing Ltd.

  4. Utility of the Neuropsychiatric Inventory Questionnaire (NPI-Q in the assessment of a sample of patients with Alzheimer's disease in Chile

    Directory of Open Access Journals (Sweden)

    Gada Musa

    Full Text Available ABSTRACT The Neuropsychiatric Inventory Questionnaire (NPI-Q is an informant-based instrument that measures the presence and severity of 12 Neuropsychiatric Symptoms (NPS in patients with dementia, as well as informant distress. Objective: To measure the psychometric properties of the NPI-Q and the prevalence of NPS in patients with Alzheimer's disease (AD in Chile. Methods: 53 patients with AD were assessed. Subjects were divided into two different groups: mild AD (n=26 and moderate AD (n=27. Convergent validity was estimated by correlating the outcomes of the NPI-Q with Neuropsychiatric Inventory (NPI scores and with a global cognitive efficiency test (Addenbrooke's Cognitive Examination - Revised - ACE-R. Reliability of the NPI-Q was analysed by calculating its internal consistency. Prevalence of NPS was estimated with both the NPI and NPI-Q. Results: Positive and significant correlations were observed between the NPI-Q, the NPI, and the ACE-R (r=0.730; p<0.01 and 0.315; p<0.05 respectively. The instrument displayed an adequate level of reliability (Cronbach's alpha=0.783. The most prevalent NPS were apathy/indifference (62.3% and dysphoria/depression (58.5%. Conclusion: The NPI-Q exhibited acceptable validity and reliability indicators for patients with AD in Chile, indicating that it is a suitable instrument for the routine assessment of NPS in clinical practice.

  5. Role of NPY Y1 receptor on acquisition, consolidation and extinction on contextual fear conditioning: dissociation between anxiety, locomotion and non-emotional memory behavior.

    Science.gov (United States)

    Lach, Gilliard; de Lima, Thereza Christina Monteiro

    2013-07-01

    Neuropeptide Y (NPY) is the most abundant peptide in the central nervous system (CNS) and is densely localized in the brain regions involved in stress, memory, fear and anxiety. Although previous research supports a role for NPY in the mediation of rodent and human emotional behavior, there is currently a lack of information on the effects of low doses of NPY that could have a potential therapeutic advantage, minimizing side-effects such as cognition impairment or sedation. Herein, we assessed the effects of intracerebroventricular (i.c.v.) administration of low doses of NPY, and of the Y1-agonist Leu31Pro34-NPY (LP-NPY) on contextual fear conditioning (CFC), as they have no effect on unconditioned anxiety-like, locomotor activity and non-emotional memory. NPY (3 pmol) and LP-NPY (1 pmol) inhibited freezing behavior when administered in the acquisition or consolidation stages, indicating a reduction of fear. When injected in the extinction phase, only NPY inhibited freezing behavior on CFC. Pre-treatment with the Y1-antagonist BIBO3304 before NPY and LP-NPY was able to prevent the inhibition of fear responses induced by both NPY agonists. Taken together, our results demonstrate robust fear-inhibiting effects of i.c.v. injection of NPY on contextual fear conditioning in rats, a response that is mediated, at least in part, by the Y1 receptor. Moreover, these treatments were unable to change locomotor activity or to show an anxiolytic-like effect, as evaluated in an open-field and an elevated plus-maze. This specific fear reduction effect may underlie resilience systems in the CNS and has potential therapeutic relevance in PTSD. Copyright © 2013 Elsevier Inc. All rights reserved.

  6. Comparison Between In-Beam and Offline Positron Emission Tomography Imaging of Proton and Carbon Ion Therapeutic Irradiation at Synchrotron- and Cyclotron-Based Facilities

    International Nuclear Information System (INIS)

    Parodi, Katia; Bortfeld, Thomas; Haberer, Thomas

    2008-01-01

    Purpose: The benefit of using dedicated in-beam positron emission tomography (PET) detectors in the treatment room instead of commercial tomographs nearby is an open question. This work quantitatively compares the measurable signal for in-beam and offline PET imaging, taking into account realistic acquisition strategies at different ion beam facilities. Both scenarios of pulsed and continuous irradiation from synchrotron and cyclotron accelerators are considered, because of their widespread use in most carbon ion and proton therapy centers. Methods and Materials: A mathematical framework is introduced to compare the time-dependent amount and spatial distribution of decays from irradiation-induced isotope production. The latter is calculated with Monte Carlo techniques for real proton treatments of head-and-neck and paraspinal tumors. Extrapolation to carbon ion irradiation is based on results of previous phantom experiments. Biologic clearance is modeled taking into account available data from previous animal and clinical studies. Results: Ratios between the amount of physical decays available for in-beam and offline detection range from 40% to 60% for cyclotron-based facilities, to 65% to 110% (carbon ions) and 94% to 166% (protons) at synchrotron-based facilities, and increase when including biologic clearance. Spatial distributions of decays during irradiation exhibit better correlation with the dose delivery and reduced influence of biologic processes. Conclusions: In-beam imaging can be advantageous for synchrotron-based facilities, provided that efficient PET systems enabling detection of isotope decays during beam extraction are implemented. For very short (<2 min) irradiation times at cyclotron-based facilities, a few minutes of acquisition time after the end of irradiation are needed for counting statistics, thus affecting patient throughput

  7. Human Lymphatic Mesenteric Vessels: Morphology and Possible Function of Aminergic and NPY-ergic Nerve Fibers.

    Science.gov (United States)

    D'Andrea, Vito; Panarese, Alessandra; Taurone, Samanta; Coppola, Luigi; Cavallotti, Carlo; Artico, Marco

    2015-09-01

    The lymphatic vessels have been studied in different organs from a morphological to a clinical point of view. Nevertheless, the knowledge of the catecholaminergic control of the lymphatic circulation is still incomplete. The aim of this work is to study the presence and distribution of the catecholaminergic and NPY-ergic nerve fibers in the whole wall of the human mesenteric lymphatic vessels in order to obtain knowledge about their morphology and functional significance. The following experimental procedures were performed: 1) drawing of tissue containing lymphatic vessels; 2) cutting of tissue; 3) staining of tissue; 4) staining of nerve fibers; 5) histofluorescence microscopy for the staining of catecholaminergic nerve fibers; 6) staining of neuropeptide Y like-immune reactivity; 7) biochemical assay of proteins; 8) measurement of noradrenaline; 9) quantitative analysis of images; 10) statistical analysis of data. Numerous nerve fibers run in the wall of lymphatic vessels. Many of them are catecholaminergic in nature. Some nerve fibers are NPY-positive. The biochemical results on noradrenaline amounts are in agreement with morphological results on catecholaminergic nerve fibers. Moreover, the morphometric results, obtained by the quantitative analysis of images and the subsequent statistical analysis of data, confirm all our morphological and biochemical data. The knowledge of the physiological or pathological mechanism regulating the functions of the lymphatic system is incomplete. Nevertheless the catecholaminergic nerve fibers of the human mesenteric lymphatic vessels come from the adrenergic periarterial plexuses of the mesenterial arterial bed. NPY-ergic nerve fibers may modulate the microcirculatory mesenterial bed in different pathological conditions.

  8. Development of neuropeptide Y (NPY) immunoreactive neurons in the rat occipital cortex: A combined immunohistochemical-autoradiographic study

    International Nuclear Information System (INIS)

    Cavanagh, M.E.; Parnavelas, J.G.

    1990-01-01

    The postnatal development of neuropeptide Y (NPY)-immunoreactive neurons, previously labeled with [3H]thymidine on embryonic days E14-E21, has been studied in the rat occipital cortex. Immunohistochemistry combined with autoradiography showed evidence of a modified inside-out pattern of maturation. NPY-neurons are generated between E14 and E20 and are found in layers II-VI of the cortex and the subcortical white matter. NPY neurons from all these birthdates are overproduced at first, although cells generated at E16 produce the greatest excess, followed by E15 and E17. Some of these transient neurons are found in the wrong layer for their birthdates, and their elimination produces a more correct alignment at maturity. However, most of the NPY neurons that survive are generated at E17, and these cells are found throughout layers II-VI with a preponderance in layer VI. This evidence is strongly suggestive of cell death rather than merely cessation of production of NPY

  9. Nuclear exportin receptor CAS regulates the NPI-1-mediated nuclear import of HIV-1 Vpr.

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    Eri Takeda

    Full Text Available Vpr, an accessory protein of human immunodeficiency virus type 1, is a multifunctional protein that plays an important role in viral replication. We have previously shown that the region between residues 17 and 74 of Vpr (Vpr(N17C74 contained a bona fide nuclear localization signal and it is targeted Vpr(N17C74 to the nuclear envelope and then imported into the nucleus by importin α (Impα alone. The interaction between Impα and Vpr is important not only for the nuclear import of Vpr but also for HIV-1 replication in macrophages; however, it was unclear whether full-length Vpr enters the nucleus in a manner similar to Vpr(N17C74. This study investigated the nuclear import of full-length Vpr using the three typical Impα isoforms, Rch1, Qip1 and NPI-1, and revealed that full-length Vpr is selectively imported by NPI-1, but not Rch1 and Qip1, after it makes contact with the perinuclear region in digitonin-permeabilized cells. A binding assay using the three Impα isoforms showed that Vpr bound preferentially to the ninth armadillo repeat (ARM region (which is also essential for the binding of CAS, the export receptor for Impα in all three isoforms. Comparison of biochemical binding affinities between Vpr and the Impα isoforms using surface plasmon resonance analysis demonstrated almost identical values for the binding of Vpr to the full-length isoforms and to their C-terminal domains. By contrast, the data showed that, in the presence of CAS, Vpr was released from the Vpr/NPI-1 complex but was not released from Rch1 or Qip1. Finally, the NPI-1-mediated nuclear import of Vpr was greatly reduced in semi-intact CAS knocked-down cells and was recovered by the addition of exogenous CAS. This report is the first to show the requirement for and the regulation of CAS in the functioning of the Vpr-Impα complex.

  10. Changes in the nutritional quality of fast-food items marketed at restaurants, 2010 v. 2013.

    Science.gov (United States)

    Soo, Jackie; Harris, Jennifer L; Davison, Kirsten K; Williams, David R; Roberto, Christina A

    2018-03-27

    To examine the nutritional quality of menu items promoted in four (US) fast-food restaurant chains (McDonald's, Burger King, Wendy's, Taco Bell) in 2010 and 2013. Menu items pictured on signs and menu boards were recorded at 400 fast-food restaurants across the USA. The Nutrient Profile Index (NPI) was used to calculate overall nutrition scores for items (higher scores indicate greater nutritional quality) and was dichotomized to denote healthier v. less healthy items. Changes over time in NPI scores and energy of promoted foods and beverages were analysed using linear regression. Four hundred fast-food restaurants (McDonald's, Burger King, Wendy's, Taco Bell; 100 locations per chain). NPI of fast-food items marketed at fast-food restaurants. Promoted foods and beverages on general menu boards and signs remained below the 'healthier' cut-off at both time points. On general menu boards, pictured items became modestly healthier from 2010 to 2013, increasing (mean (se)) by 3·08 (0·16) NPI score points (Prestaurants showed limited improvements in nutritional quality in 2013 v. 2010.

  11. Validation of computational methods for treatment planning of fast-neutron therapy using activation foil techniques

    International Nuclear Information System (INIS)

    Nigg, D.W.; Wemple, C.A.; Hartwell, J.K.; Harker, Y.D.; Venhuizen, J.R.; Risler, R.

    1997-12-01

    A closed-form direct method for unfolding neutron spectra from foil activation data is presented. The method is applied to measurements of the free-field neutron spectrum produced by the proton-cyclotron-based fast-neutron radiotherapy facility at the University of Washington (UW) School of Medicine. The results compare favorably with theoretical expectations based on an a-priori calculational model of the target and neutron beamline configuration of the UW facility

  12. Trans-arterial xenotransplantation (Tx) of newborn porcine islet (NPI). A clinic trial for type I diabetes

    International Nuclear Information System (INIS)

    Wang Wei; Mo Zhaohui; Huang Zufa; Luo Xianming; Liu Sheng; Ye Bin; Li Bing; Liu Yingxin

    2002-01-01

    Objective: Liver is an important site to host transplanted islets, and implanting of islets by hepatic artery is simpler than by portal vein. Authors' study evaluated efficiency of the method and possible complication in a clinical setting. Methods: From October 1998 to June 2000, 4 type I diabetic patients received 4 x 10 6 (2 cases) and 8 x 10 6 (2 cases) of NPI through hepatic artery. Before Tx, all cases had the history with ketosis and acidosis. Exogenous insulin doses used for these cases were 25-48 units and their GHb was 9%-11%. After Tx, the NPI recipients were treated with immunosuppressants including cyclosporin 8 mg/kg for 12 months, cellcept 2 g/d for 25 days, and methylprednisolone 500 mg at 1 st day, then reduced to 50 mg for 3 days until to 10 mg for 1 month. Liver function and CD4/CD8 of the recipients were measured before and after Tx. Results: After Tx, the dose of exogenous insulin was increased to 60 mg due to methylprednisolone treatment. When methylprednisolone dose was decreased, the requirement for insulin was reduced to 32%-58% of the dose used before Tx. The reduction of required insulin for NPI recipients was proportional to the number of implanted NPI. In addition, GHb was also reduced to normal level (4%-6%) 3 months after Tx. No significant alterations of liver function and CD4 and CD8 in blood were observed after Tx. Conclusion: Trans-arterial intro-hepatic xenotransplantation of NPI is an efficient and safe therapeutic method for type I diabetes. Combination of cyclosporin, cellcept, and methylprednisolone is an effective immunosuppressive strategy for NPI xenograft transplantation

  13. Clinical significance of measurement of changes of plasma NPY, CGRP and serum IGF-I levels in patients with acute cerebral infarction

    International Nuclear Information System (INIS)

    Deng Weiqun; Zhao Yushan

    2007-01-01

    Objective: To investigate the clinical significance of changes of plasma NPY, CGRP and serum IGF-I levels in patients with acute cerebral infarction. Methods: Plasma NPY, CGRP and serum IGF-I levels were determined with RIA in 32 patients with acute cerebral infarction both before and after treatment and 30 controls. Results: Before treatment plasma NPY levels were significantly higher (P<0.01) than those in the controls, while plasma CGRP and serum IGF-I levels were lower than those in controls (P<0.01). After treatment, plasma NPY levels decreased significantly (vs before treatment P<0.05), and plasma CGRP and serum IGF-I levels increased (P<0.05). Conclusion: Changes of plasma NPY, CGRP and serum IGF-I levels were closely related to the disease process in patients with acute cerebral infarction, determination of which was of important clinical values. (authors)

  14. Clinical significance of measurement of changes of plasma leptin and serum NPY levels after hemodialysis in patients with chronic renal failure

    International Nuclear Information System (INIS)

    Xia Zhengping

    2010-01-01

    Objective: To explore the clinical significance of changes of plasma leptin and serum NPY levels after hemodialysis in patients with chronic renal failure. Methods: Plasma leptin and serum NPY levels were measured with RIA both before and after hemodialysis in 31 patients with chronic renal failure as well as in 35 controls. Results: Before hemodialysis,plasma leptin and serum NPY levels were significantly higher in the patients than those in controls (P<0.01). After hemodialysis for 1 week the levels, though dropped markedly, still remained significantly higher than those in controls (P<0.05). Conclusion: The levels of leptin and NPY were significantly increased in patients with chronic renal failare. Hemodialysis could increase, the clearance rate of leptin and NPY and partially correct the levels with important clinical value. (authors)

  15. Primary study on the clinical significance of measurement of epidermal growth factor (EGF) and NPY concentrations in human semen plasma

    International Nuclear Information System (INIS)

    Zhang Jiyun; Ning Yong

    2008-01-01

    Objective: To investigate the difference between the semen plasma contents of EGF and NPY in fertile and non-fertile males with the relevant sperm count and motility. Methods: Semen plasma contents of EGF and NPY were determined with RIA in 110 non-fertile males. Simultaneous semen analysis revealed (1) Group A, n=45, with normal sperm count, (2) Group B, n=34 low sperm count (0-20) x 10 6 /ml and (3) Group C n=31, with aspermia. White blood cell/HPF was examined in all the semen specimens and sperm motile rate and motility were examined in Group A specimens. Results: The semen plasma contents of EGF and NPY in non-fertile males were significantly higher than those in fertile males (P 1 x 10 6 /ml) were significantly lower than those in specimens with more white blood cells (P<0.05). Conclusion: Higher semen plasma contents of EGF and NPY might exert toxic effect on the sperms, contributing to the development of infertility. (authors)

  16. Clinical significance of determination of plasma leptin, NPY and serum Hcy levels in patients with chronic renal diseases

    International Nuclear Information System (INIS)

    Lu Zhifeng

    2010-01-01

    Objective: To study the relationship between progress of disease and blood levels of leptin, NPY, Hcy in patients with chronic renal diseases. Methods: Plasma leptin, NPY (with RIA) and serum Hcy (with CLIA) were determined in (1) 32 patients with chronic pyelonephritis (2) 28 patients with dibetic nephropathy (3) 30 patients with chronic renal failure and (4) 30 controls. Results: Blood levels of leptin, NPY and Hcy were slightly higher in patients with chronic pyelonephritis than those in controls but without significance (P>0.05). In patients with diabetic nephropathy, the plasma leptin and serum Hcy levels were significantly higher than those in controls (P 0.05). In patients with chronic renal failure,the blood levels of NPY (P<0.05) and leptin, Hcy (P<0.01) were all significantly higher than those in controls. Conclusion: Blood levels of these three parameters especially leptin and Hcy, were increased in patients with chronic renal diseases and the increase was most significant in advanced cases. (authors)

  17. Insulin Detemir Causes Lesser Weight Gain in Comparison to Insulin Glargine: Role on Hypothalamic NPY and Galanin

    Directory of Open Access Journals (Sweden)

    Mohammad Ishraq Zafar

    2014-01-01

    Full Text Available Objective. Compared with other insulin analogues, insulin detemir induces less weight gain. This study investigated whether this effect was achieved by influencing the hypothalamic appetite regulators neuropeptide Y (NPY and galanin (GAL. Methods. Type  2 diabetic rat models were established with a high-fat diet and intraperitoneal injection of STZ. All rats were divided into NC, DM, DM+DE and DM+GLA groups. Glycemic levels of all study groups were checked at study onset and after 4 weeks of insulin treatment. Food intake and body weight were monitored during treatment. After 4 weeks, the hypothalamus of rats was examined for NPY and GAL mRNA and protein expression. Results. After 4 weeks of treatment, compared with the DM+GLA group, the DM+DE group exhibited less food intake (P<0.05 and less weight gain (P<0.05, but showed similar glycemic control. The expression of hypothalamic NPY and GAL at both mRNA and protein level were significantly lower (P<0.05 in the DM+DE group. Conclusion. Insulin detemir decreased food intake in type 2 diabetic rats, which led to reduced weight gain when compared to insulin glargine treatment. This effect is likely due to downregulation of hypothalamic NPY and GAL.

  18. Effects of plasma CGRP and NPY level changes on intestinal mucosal barrier injury after scald in rats

    International Nuclear Information System (INIS)

    Shao Lijian; Zhu Qingxian; He Ming; Zhang Hongyan

    2004-01-01

    Objective: To investigate the significance of plasma CGRP and NPY levels changes immediately after scald in rats. Methods: Thirty-two rat models of 30% TBSA III degree scald were prepared. Eight animals each were sacrificed at 3, 6,12 and 24 hrs; taking blood samples for determination of plasma CGRP, NPY levels and 5 cm of ileum for pathologic study. As controls, eight animals without scald were treated in the same way. Results: Plasma CGRP levels were decreased significantly after scald, reaching bottom value at 12 hr and remained lower than those in controls at 24 hr (p 0.05). Plasma levels of CGRP were negatively correlated to plasma NPY levels (p<0.01). Ileum mucosal injuries presented as edema, congestion with necrosis and slough of epithelium were most marked at 12 hr. Conclusion: Plasma CGRP and NPY levels changed significantly after scald and were mutually negatively correlated. Post-scald intestinal mucosa barrier injuries were possibly related to the changes of levels of those vasoactive peptides

  19. Proton and deuteron activation measurements at the NPI and future plans in SPIRAL2/NFS

    Science.gov (United States)

    Šimečková, Eva; Bém, Pavel; Mrázek, Jaromír; Štefánik, Milan; Běhal, Radomír; Gladolev, Vadim

    2017-09-01

    The proton- and deuteron-induced reactions are of a great interest for the assessment of induced radioactivity of accelerator components, target and beam stoppers as well as isotope production for medicine. In the present work, the deuteron-induced reaction cross sections on zinc were investigated by stacked-foil activation technique with deuteron beam of 20 MeV energy from the cyclotron U-120M of NPI CAS Řež. Also the proton activation cross section measurement of iron is presented. The comparison of present results to data of other authors and to predictions of evaluated data libraries is discussed. The investigation shall continue for higher proton and deuteron energy interval 20-35 MeV at SPIRAL2/NFS facility using a charged particle irradiation chamber with pneumatic transport system to measure isotopes and isomers with half-lives in minutes-regions.

  20. Motivating consumers for National Programme on Immunization (NPI) and Oral Rehydration Therapy (ORT) in Nigeria.

    Science.gov (United States)

    Ekerete, P P

    1997-01-01

    The Expanded Programme on Immunization (EPI) (changed to National Programme on Immunization (NPI) in 1996) and Oral Rehydration Therapy (ORT) were launched in Nigeria in 1979. The goal of EPI was Universal Childhood Immunization (UCI) 1990, that is, to vaccinate 80% of all children age 0-2 years by 1990, and 80% of all pregnant women were also expected to be vaccinated with Tetanus Toxoid Vaccine. The Oral Rehydration Therapy was designed to teach parents with children age 0-5 years how to prepare and use a salt-sugar solution to rehydrate children dehydrated by diarrhoea. Nigeria set up Partners-in-Health to mobilize and motivate mothers to accept the programme. In 1990 a National coverage survey was conducted to assess the level of attainment. The results show that some states were able to reach the target and some were not. It therefore became necessary to evaluate the contribution of those promotional elements adopted by Partners-in-Health to motivate mothers to accept the programme. The respondents were therefore asked to state the degree to which these elements motivated them to accept the programme. The data were collected and processed through a Likert rating scale and t-test procedure for test of significance between two sample means. The study revealed that some elements motivated mothers very strongly, others strongly, and most moderately or low, with health workers as major sources of motivation. The study also revealed that health workers alone can not sufficiently motivate mothers without the help of religious leaders, traditional leaders and mass media, etc. It was therefore recommended that health workers should be intensively used along with other promotional elements to promote the NPI/ORT programme in Nigeria.

  1. Reversed synaptic effects of hypocretin and NPY mediated by excitatory GABA-dependent synaptic activity in developing MCH neurons.

    Science.gov (United States)

    Li, Ying; Xu, Youfen; van den Pol, Anthony N

    2013-03-01

    In mature neurons, GABA is the primary inhibitory neurotransmitter. In contrast, in developing neurons, GABA exerts excitatory actions, and in some neurons GABA-mediated excitatory synaptic activity is more prevalent than glutamate-mediated excitation. Hypothalamic neuropeptides that modulate cognitive arousal and energy homeostasis, hypocretin/orexin and neuropeptide Y (NPY), evoked reversed effects on synaptic actions that were dependent on presynaptic GABA release onto melanin-concentrating hormone (MCH) neurons. MCH neurons were identified by selective green fluorescent protein (GFP) expression in transgenic mice. In adults, hypocretin increased GABA release leading to reduced excitation. In contrast, in the developing brain as studied here with analysis of miniature excitatory postsynaptic currents, paired-pulse ratios, and evoked potentials, hypocretin acted presynaptically to enhance the excitatory actions of GABA. The ability of hypocretin to enhance GABA release increases inhibition in adult neurons but paradoxically enhances excitation in developing MCH neurons. In contrast, NPY attenuation of GABA release reduced inhibition in mature neurons but enhanced inhibition during development by attenuating GABA excitation. Both hypocretin and NPY also evoked direct actions on developing MCH neurons. Hypocretin excited MCH cells by activating a sodium-calcium exchanger and by reducing potassium currents; NPY reduced activity by increasing an inwardly rectifying potassium current. These data for the first time show that both hypocretin and NPY receptors are functional presynaptically during early postnatal hypothalamic development and that both neuropeptides modulate GABA actions during development with a valence of enhanced excitation or inhibition opposite to that of the adult state, potentially allowing neuropeptide modulation of use-dependent synapse stabilization.

  2. Leptin, neuropeptide Y (NPY), melatonin and zinc levels in experimental hypothyroidism and hyperthyroidism: relation with melatonin and the pineal gland.

    Science.gov (United States)

    Baltaci, Abdulkerim Kasım; Mogulkoc, Rasim

    2018-03-02

    Background Melatonin, an important neurohormone released from the pineal gland, is generally accepted to exercise an inhibitor effect on the thyroid gland. Zinc mediates the effects of many hormones and is found in the structure of numerous hormone receptors. Aim The present study aims to examine the effect of melatonin supplementation and pinealectomy on leptin, neuropeptide Y (NPY), melatonin and zinc levels in rats with hypothyroidism and hyperthyroidism. Methods This study was performed on the 70 male rats. Experimental animals in the study were grouped as follows: control (C); hypothyroidism (PTU); hypothyroidism + melatonin (PTU + M); hypothyroidism + pinealectomy (PTU + Pnx); hyperthyroidism (H); hyperthyroidism + melatonin (H + M) and hyperthyroidism + pinealectomy (H + Pnx). Blood samples collected at the end of 4-week procedures were analyzed to determine melatonin, leptin, NPY and zinc levels. Results It was found that thyroid parameters thyroid stimulating hormone (TSH), free triiodthyronine (FT3), free thyroxine (FT4), total T3 (TT3) and total T4 (TT4) decreased in hypothyroidism groups and increased in the groups with hyperthyroidism. The changes in these hormones remained unaffected by melatonin supplementation and pinealectomy. Melatonin levels rose in hyperthyroidism and fell in hypothyroidism. Leptin and NPY levels increased in both hypothyroidism and hyperthyroidism. Zinc levels, on the other hand, decreased in hypothyroidism and pinealectomy, but increased in hyperthyroidism. Conclusion The results of the study demonstrate that hypothyroidism and hyperthyroidism affect leptin, NPY, melatonin and zinc values in different ways in rats. However, melatonin supplementation and pinealectomy do not have any significant influence on the changes occurring in leptin, NPY and zinc levels in thyroid dysfunction.

  3. Correlations of serum levels of TG with leptin and other related factors (L-1, NPY adiponectin) in patients with hyperlipidaemia

    International Nuclear Information System (INIS)

    Wang Donghong; Yu Ping; Wei Jingjun

    2007-01-01

    Objective: To study the changes and correlations of serum levels of triglyeride (TG), leptin, L -1, neuropeptide Y (NPY) and adiponectin in patients with hypertriglyceridemia (HTG). Methods: Serum levels of TG, leptin, L-1, NPY and adiponectin in 54 patients with HTG and 55 controls were measured with radioimmunoassay (RIA). Results: The serum levels of TG, Leptin, L -1 and NPY in patients with HTG [ (3.46 ± 1.14) mmol/L, (10.56 ±3.79) μg/L, (0.40 ± 0.18) μg/L, (115.89 ± 24.56) μg/L, respectively] were significantly higher than those in controls [ (1.26 ± 0.30) mmol/L, (5.66 ± 2.01) μg/L, (0.22 ± 0.09) μg/L, (95.21 ± 16.85) μg/L, respectively] P < 0.01 in all. But serum levels of adiponectin in patients with HTG (8.98 ± 3.51μg/L) was significantly lower than those in controls [(13.21 ± 9.46) μg/L, P < 0.01]. There were significantly positive correlations between serum TG levels and serum levels of leptin (r = 0.576, P < 0.05). There were also significantly positive correlations between serum leptin levels and serum levels of L-1 and NPY (r = 0.582; r = 0.479, respectively, P < 0.05). Conclusion: There was close relationship between increase in serum TG level and changes of serum levels of leptin, L-1, NPY, adiponectin. Neural-endocrine-immune system participated in fatty metabolism and could result in HTG. (authors)

  4. Television imaging system for fast neutron radiography using baby cyclotron

    International Nuclear Information System (INIS)

    Yoshii, Koji; Miya, Kenzo; Katoh, Norihiko.

    1993-01-01

    A television imaging system for fast neutron radiography (FNR-TV) developed using the fast neutron source reactor YAYOI was applied to the baby-cyclotron based fast neutron source to get images of thick objects quickly. In the system the same technique as a current television imaging system of thermal neutron radiography was applied, while the luminescent converter was used to detect fast neutrons. Using the CR39 track etch method it took about 7 h to get an image, while the FNR-TV only 20 s enough for taking the same object. However the FNR-TV imaging result of the simulation model of a large explosive device for the space launch vehicle of H-2 type was not so good as the image taken with the CR39 track etch method. The reason was that the luminescence intensity of the FNR-TV converter was a quarter of that in the YAYOI. (author)

  5. Clinical significance of measurement of changes of serum NSE and plasma NPY levels after treatment in pediatric patients with viral encephalitis

    International Nuclear Information System (INIS)

    Jin Bo; Zheng Guo

    2007-01-01

    Objective: To explore the significance ef changes of serum NSE and plasma NPY levels after treatment in pediatric patients with viral encephalitis. Methods: Serum NSE and plasma NPY levels were measured with RIA in 32 pediatric patients with viral encephalitis both before and after treatment as well as in 30 controls. Results: Before treatment, in the patients, the serum NSE and plasma NPY levels were significantly higher than those in controls (P<0.01). After 1 month's treatment the levels dropped markedly but still remained significantly higher than those in controls (P<0.05). Conclusion: Serum NSE and plasma NPY levels changes were closely related to the progress of viral encephalitis. (authors)

  6. Clinical relevance of determination the changes of serum cTnI, NPY and PGMP contents after treatment in patients with coronary heart diseases

    International Nuclear Information System (INIS)

    Ge Hengsong; Ma Chao; Wu Kaixia

    2011-01-01

    Objective: To explore the clinical significance of changes of serum cTnI, NPY and PGMP levels in patients with coronary heart diseases after treatment. Methods: Serum NPY, PGMP (with RIA), serum cTnI (with Biochemistry) levels were measured in 41 patients with coronary heart diseases both before and after treatment as well as in 35 normal controls. Results: Before treatment, serum cTnI, NPY and PGMP levels were significantly higher than those in controls (P 0.05), but serum PGMP level remained prominently higher (P<0.05). Conclusion: Pathogenesis and progress of CHD, might be closely related to serum cTnI, NPY and PGMP levels. (authors)

  7. Proliferative hypothalamic neurospheres express NPY, AGRP, POMC, CART and Orexin-A and differentiate to functional neurons.

    Directory of Open Access Journals (Sweden)

    Lígia Sousa-Ferreira

    Full Text Available Some pathological conditions with feeding pattern alterations, including obesity and Huntington disease (HD are associated with hypothalamic dysfunction and neuronal cell death. Additionally, the hypothalamus is a neurogenic region with the constitutive capacity to generate new cells of neuronal lineage, in adult rodents. The aim of the present work was to evaluate the expression of feeding-related neuropeptides in hypothalamic progenitor cells and their capacity to differentiate to functional neurons which have been described to be affected by hypothalamic dysfunction. Our study shows that hypothalamic progenitor cells from rat embryos grow as floating neurospheres and express the feeding-related neuropeptides Neuropeptide Y (NPY, Agouti-related Protein (AGRP, Pro-OpioMelanocortin (POMC, Cocaine-and-Amphetamine Responsive Transcript (CART and Orexin-A/Hypocretin-1. Moreover the relative mRNA expression of NPY and POMC increases during the expansion of hypothalamic neurospheres in proliferative conditions.Mature neurons were obtained from the differentiation of hypothalamic progenitor cells including NPY, AGRP, POMC, CART and Orexin-A positive neurons. Furthermore the relative mRNA expression of NPY, CART and Orexin-A increases after the differentiation of hypothalamic neurospheres. Similarly to the adult hypothalamic neurons the neurospheres-derived neurons express the glutamate transporter EAAT3. The orexigenic and anorexigenic phenotype of these neurons was identified by functional response to ghrelin and leptin hormones, respectively. This work demonstrates the presence of appetite-related neuropeptides in hypothalamic progenitor cells and neurons obtained from the differentiation of hypothalamic neurospheres, including the neuronal phenotypes that have been described by others as being affected by hypothalamic neurodegeneration. These in vitro models can be used to study hypothalamic progenitor cells aiming a therapeutic intervention to

  8. Glut2-dependent glucose-sensing controls thermoregulation by enhancing the leptin sensitivity of NPY and POMC neurons.

    Science.gov (United States)

    Mounien, Lourdes; Marty, Nell; Tarussio, David; Metref, Salima; Genoux, David; Preitner, Frédéric; Foretz, Marc; Thorens, Bernard

    2010-06-01

    The physiological contribution of glucose in thermoregulation is not completely established nor whether this control may involve a regulation of the melanocortin pathway. Here, we assessed thermoregulation and leptin sensitivity of hypothalamic arcuate neurons in mice with inactivation of glucose transporter type 2 (Glut2)-dependent glucose sensing. Mice with inactivation of Glut2-dependent glucose sensors are cold intolerant and show increased susceptibility to food deprivation-induced torpor and abnormal hypothermic response to intracerebroventricular administration of 2-deoxy-d-glucose compared to control mice. This is associated with a defect in regulated expression of brown adipose tissue uncoupling protein I and iodothyronine deiodinase II and with a decreased leptin sensitivity of neuropeptide Y (NPY) and proopiomelanocortin (POMC) neurons, as observed during the unfed-to-refed transition or following i.p. leptin injection. Sites of central Glut-2 expression were identified by a genetic tagging approach and revealed that glucose-sensitive neurons were present in the lateral hypothalamus, the dorsal vagal complex, and the basal medulla but not in the arcuate nucleus. NPY and POMC neurons were, however, connected to nerve terminals from Glut2-expressing neurons. Thus, our data suggest that glucose controls thermoregulation and the leptin sensitivity of NPY and POMC neurons through activation of Glut2-dependent glucose-sensing neurons located outside of the arcuate nucleus.

  9. Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects.

    Science.gov (United States)

    Ukkola, O; Kesäniemi, Y A

    2007-09-01

    Neuropeptide Y (NPY) plays a central in energy homeostasis and potentially in the development of obesity-related comorbidities, like type II diabetes. As the PreproNPY Leu7Pro polymorphism probably changes the intracellular processing of the synthesized preproNPY peptide, we assessed the hypothesis that PreproNPY Leu7Pro polymorphism is a risk factor for type II diabetes, impaired glucose tolerance and hypertension. Blood pressure recordings and oral glucose tolerance test were performed in the hypertensive (n=515) and control cohorts (n=525) of our well-defined Oulu Project Elucidating Risk of Atherosclerosis (OPERA) study. The prevalence of type II diabetes was 9% (n=93). The genotypes, insulin and glucose metabolism indexes and plasma ghrelin of the subjects were determined. Pro7 allele frequencies were 5.9, 5.3 and 11.3% in the total cohort, in subjects without and with type II diabetes, respectively. The PreproNPY Pro7 carrier status was a significant risk factor for type II diabetes, and the effect remained significant after adjustment for age, sex, waist circumference and study group (odds ratio=3.02, confidence interval: 1.67-5.44 and Pghrelin levels compared to non-carriers. The PreproNPY Pro7 allele is associated with an increased risk for type II diabetes. The risk seems to be associated with a higher insulin resistance among Pro7 carriers whereas low ghrelin concentrations in Pro7 carriers are possibly a consequence of high insulin levels.

  10. Social media connecting ocean sciences and the general public: the @OceanSeaIceNPI experiment

    Science.gov (United States)

    Pavlov, A. K.; Granskog, M. A.; Gerland, S.; Meyer, A.; Hudson, S. R.; Rösel, A.; King, J.; Itkin, P.; Cohen, L.; Dodd, P. A.; de Steur, L.

    2016-02-01

    As researchers we are constantly being encouraged by funding agencies, policy-makers and journalists to conduct effective outreach and to communicate our latest research findings. As environmental scientists we also understand the necessity of communicating our research to the general public. Many of us wish to become better science communicators but have little time and limited funding available to do so. How can we expend our science communication past project-based efforts that have a limited lifetime? Most critically, how can a small research groups do it without additional resources such as funds and communication officers? Social media is one answer, and has become a powerful and inexpensive tool for communicating science to different target audiences. Many research institutions and researchers are exploring the full breadth of possibilities brought by social media for reaching out to the general public, journalists, policy-makers, stake-holders, and research community. However, smaller research groups and labs are still underrepresented in social media. When it comes to practice, some essential difficulties can be encountered: identifying key target groups, defining the framework for sharing responsibilities and interaction within the research group, and finally, choosing a currently up-to-date social medium as a technical solution for communicating your research. Here, a group of oceanography and sea ice researchers (@OceanSeaIceNPI) share the positive experience of developing and maintaining for more than one year a researcher-driven outreach effort currently implemented through Instagram, Twitter and Facebook. We will present potential pitfalls and challenges that small research groups could face, and how to better overcome them. This will hopefully inspire and help other research groups and labs to conduct their own effective ocean science communication.

  11. Effects of Dietary Acute Tryptophan Depletion (ATD) on NPY Serum Levels in Healthy Adult Humans Whilst Controlling for Methionine Supply—A Pilot Study

    Science.gov (United States)

    Wong, Janice W. Y.; Morandini, Hugo A. E.; Dingerkus, Vita L. S.; Gaber, Tilman J.; Runions, Kevin C.; Mahfouda, Simone; Helmbold, Katrin; Bubenzer-Busch, Sarah; Koenemann, Rebecca; Stewart, Richard M.; Zepf, Florian D.

    2018-01-01

    Central nervous serotonin (5-HT) can influence behaviour and neuropsychiatric disorders. Evidence from animal models suggest that lowered levels of neuropeptide Y (NPY) may have similar effects, although it is currently unknown whether decreased central nervous 5-HT impact NPY concentrations. Given that the production of NPY is dependent on the essential amino acid methionine (MET), it is imperative to account for the presence of MET in such investigations. Hence, this study sought to examine the effects of acute tryptophan depletion (ATD; a dietary procedure that temporarily lowers central nervous 5-HT synthesis) on serum concentrations of NPY, whilst using the potential renal acid load indicator (PRAL) to control for levels of MET. In a double-blind repeated measures design, 24 adult humans randomly received an AA-load lacking in TRP (ATD) on one occasion, and a balanced control mixture with TRP (BAL) on a second occasion, both with a PRAL of nearly 47.3 mEq of MET. Blood samples were obtained at 90, 180, and 240 min after each of the AA challenges. ATD, and therefore, diminished substrate availability for brain 5-HT synthesis did not lead to significant changes in serum NPY concentrations over time, compared to BAL, under an acute acidotic stimulus. PMID:29751614

  12. Measurement of the generalized form factors near threshold via $\\gamma^* p \\to n\\pi^+$ at high $Q^2$

    OpenAIRE

    Park, Kijun; Gothe, Ralf; Adhikari, Krishna; Adikaram-Mudiyanselage, Dasuni; Anghinolfi, Marco; Baghdasaryan, Hovhannes; Ball, Jacques; Battaglieri, Marco; Baturin, Vitaly; Bedlinskiy, Ivan; Bennett, Robert; Biselli, Angela; Bookwalter, Craig; Boyarinov, Sergey; Branford, Derek

    2012-01-01

    We report the first extraction of the pion-nucleon multipoles near the production threshold for the $n\\pi^+$ channel at relatively high momentum transfer ($Q^2$ up to 4.2 $\\rm{GeV^2}$). The dominance of the s-wave transverse multipole ($E_{0+}$), expected in this region, allowed us to access the generalized form factor $G_1$ within the light-cone sum rule (LCSR) framework as well as the axial form factor $G_A$. The data analyzed in this work were collected by the nearly $4\\pi$ CEBAF Large Acc...

  13. Feed intake and brain neuropeptide Y (NPY) and cholecystokinin (CCK) gene expression in juvenile cobia fed plant-based protein diets with different lysine to arginine ratios.

    Science.gov (United States)

    Nguyen, Minh Van; Jordal, Ann-Elise Olderbakk; Espe, Marit; Buttle, Louise; Lai, Hung Van; Rønnestad, Ivar

    2013-07-01

    Cobia (Rachycentron canadum, Actinopterygii, Perciformes;10.5±0.1g) were fed to satiation with three plant-based protein test diets with different lysine (L) to arginine (A) ratios (LL/A, 0.8; BL/A, 1.1; and HL/A, 1.8), using a commercial diet as control for six weeks. The test diets contained 730 g kg(-1) plant ingredients with 505-529 g protein, 90.2-93.9 g lipid kg(-1) dry matter; control diet contained 550 g protein and 95 g lipid kg(-1) dry matter. Periprandial expression of brain NPY and CCK (npy and cck) was measured twice (weeks 1 and 6). At week one, npy levels were higher in pre-feeding than postfeeding cobia for all diets, except LL/A. At week six, npy levels in pre-feeding were higher than in postfeeding cobia for all diets. cck in pre-feeding cobia did not differ from that in postfeeding for all diets, at either time point. Cobia fed LL/A had lower feed intake (FI) than cobia fed BL/A and control diet, but no clear correlations between dietary L/A ratio and FI, growth and expression of npy and cck were detected. The data suggest that NPY serves as an orexigenic factor, but further studies are necessary to describe links between dietary L/A and regulation of appetite and FI in cobia. Copyright © 2013 Elsevier Inc. All rights reserved.

  14. Association of neuropeptide Y (NPY, interleukin-1B (IL1B genetic variants and correlation of IL1B transcript levels with vitiligo susceptibility.

    Directory of Open Access Journals (Sweden)

    Naresh C Laddha

    Full Text Available BACKGROUND: Vitiligo is a depigmenting disorder resulting from loss of functional melanocytes in the skin. NPY plays an important role in induction of immune response by acting on a variety of immune cells. NPY synthesis and release is governed by IL1B. Moreover, genetic variability in IL1B is reported to be associated with elevated NPY levels. OBJECTIVES: Aim of the present study was to explore NPY promoter -399T/C (rs16147 and exon2 +1128T/C (rs16139 polymorphisms as well as IL1B promoter -511C/T (rs16944 polymorphism and to correlate IL1B transcript levels with vitiligo. METHODS: PCR-RFLP method was used to genotype NPY -399T/C SNP in 454 patients and 1226 controls; +1128T/C SNP in 575 patients and 1279 controls and IL1B -511C/T SNP in 448 patients and 785 controls from Gujarat. IL1B transcript levels in blood were also assessed in 105 controls and 95 patients using real-time PCR. RESULTS: Genotype and allele frequencies for NPY -399T/C, +1128T/C and IL1B -511C/T SNPs differed significantly (p<0.0001, p<0.0001; p = 0.0161, p = 0.0035 and p<0.0001, p<0.0001 between patients and controls. 'TC' haplotype containing minor alleles of NPY polymorphisms was significantly higher in patients and increased the risk of vitiligo by 2.3 fold (p<0.0001. Transcript levels of IL1B were significantly higher, in patients compared to controls (p = 0.0029, in patients with active than stable vitiligo (p = 0.015, also in female patients than male patients (p = 0.026. Genotype-phenotype correlation showed moderate association of IL1B -511C/T polymorphism with higher IL1B transcript levels. Trend analysis revealed significant difference between patients and controls for IL1B transcript levels with respect to different genotypes. CONCLUSION: Our results suggest that NPY -399T/C, +1128T/C and IL1B -511C/T polymorphisms are associated with vitiligo and IL1B -511C/T SNP influences its transcript levels leading to increased risk for vitiligo in

  15. AgRP and NPY Expression in the Human Hypothalamic Infundibular Nucleus Correlate with Body Mass Index, Whereas Changes in alpha MSH Are Related to Type 2 Diabetes

    NARCIS (Netherlands)

    Alkemade, Anneke; Yi, Chun-Xia; Pei, Lei; Harakalova, Magdalena; Swaab, Dick F.; la Fleur, Susanne E.; Fliers, Eric; Kalsbeek, Andries

    2012-01-01

    Context: Rodent data show that altered hypothalamic signaling contributes to the development of obesity and insulin resistance. Objective: To determine differences in hypothalamic expression levels of neuropeptide Y (NPY), agouti-related peptide (AgRP), and alpha MSH in the infundibular nucleus, the

  16. Distribution of peptidergic populations in the human dentate gyrus (somatostatin [SOM-28, SOM-12] and neuropeptide Y [NPY]) during postnatal development.

    Science.gov (United States)

    Cebada-Sánchez, S; Insausti, R; González-Fuentes, J; Arroyo-Jiménez, M M; Rivas-Infante, E; Lagartos, M J; Martínez-Ruiz, J; Lozano, G; Marcos, P

    2014-10-01

    The postnatal development of the human hippocampal formation establishes the time and place at which we start autobiographical memories. However, data concerning the maturation of the neurochemical phenotypes characteristic of interneurons in the human hippocampus are scarce. We have studied the perinatal and postnatal changes of the dentate gyrus (DG) interneuron populations at three rostrocaudal levels. Immunohistochemically identified neurons and fibers for somatostatin (SOM-12 and SOM-28) and neuropeptide Y (NPY) and the co-localization of SOM-28 and NPY were analyzed. In total, 13 cases were investigated from late pregnancy (1 case), perinatal period (6 cases), first year (1 case), early infancy (3 cases), and late infancy (2 cases). Overall, the pattern of distribution of these peptides in the DG was similar to that of the adult. The distribution of cells was charted, and the cell density (number of positive cells/mm(2)) was calculated. The highest density corresponded to the polymorphic cell layer and was higher at pre- and perinatal periods. At increasing ages, neuron density modifications revealed a decrease from 5 postnatal months onward. In contrast, by late infancy, two immunoreactive bands for SOM-28 and NPY in the molecular layer were much better defined. Double-immunohistochemistry showed that NPY-positive neurons co-localized with SOM-28, whereas some fibers contained only one or other of the neuropeptides. Thus, this peptidergic population, presumably inhibitory, probably has a role in DG maturation and its subsequent functional activity in memory processing.

  17. Experimental study of changes of skin blister fluid NPY, IL-12, sICAM-1 and GM-CSF levels in patients with vitiligo in progressive stage

    International Nuclear Information System (INIS)

    Bi Mingye; Huang Haifen

    2011-01-01

    Objective: To explore the significance of changes of skin blister fluid NPY, IL-12, sICAM-1 and GM-CSF levels in patients with vitiligo in progressive stage. Methods: 80 patients with vitiligo in progressive stage were divided into two groups (vulgaris vitiligo groups : n=54, segmental vitiligo groups : n=26) Their blister fluid levels of NPY and GM-CSF were determined by radioimmunoassay(RIA), and IL-12 and sICAM-1 were determined by enzyme immunoassay. Results: The levels of skin blister fluid NPY were definitely higher in vitiliginous skin than those in non-vitiliginous patches in segmental vitiligo groups (P 0.05). The levels of skin blister fluid IL-12, sICAM-1 and GM-CSF were all obviously higher in vitiliginous skin than that in non-vitiliginous patches in vulgaris vitiligo groups (P 0.05). Conclusion: The changes of skin blister fluid NPY, IL-12, sICAM-1 and GM-CSF levels in vitiliginous skin may be closely related to development of difference type vitiligo patients with vitiligo, determination of 4 indexes might be helpful for studying the pathogenesis and clinical diagnosis of vitiligo. (authors)

  18. Association of Neuropeptide-Y (NPY) and Interleukin-1beta (IL1B), Genotype-Phenotype Correlation and Plasma Lipids with Type-II Diabetes.

    Science.gov (United States)

    Patel, Roma; Dwivedi, Mitesh; Mansuri, Mohmmad Shoab; Ansarullah; Laddha, Naresh C; Thakker, Ami; Ramachandran, A V; Begum, Rasheedunnisa

    2016-01-01

    Neuropeptide Y (NPY) is known to play a role in the regulation of satiety, energy balance, body weight, and insulin release. Interleukin-1beta (IL1B) has been associated with loss of beta-cell mass in type-II diabetes (TIID). The present study attempts to investigate the association of NPY exon2 +1128 T/C (Leu7Pro; rs16139), NPY promoter -399 T/C (rs16147) and IL1B -511 C/T (rs16944) polymorphisms with TIID and their correlation with plasma lipid levels, BMI, and IL1B transcript levels. PCR-RFLP was used for genotyping these polymorphisms in a case-control study involving 558 TIID patients and 1085 healthy age-matched controls from Gujarat. Linkage disequilibrium and haplotype analysis of the NPY polymorphic sites were performed to assess their association with TIID. IL1B transcript levels in PBMCs were also assessed in 108 controls and 101 patients using real-time PCR. Our results show significant association of both structural and promoter polymorphisms of NPY (p<0.0001 and p<0.0001 respectively) in patients with TIID. However, the IL1B C/T polymorphism did not show any association (p = 0.3797) with TIID patients. Haplotype analysis revealed more frequent association of CC and CT haplotypes (p = 3.34 x 10-5, p = 6.04 x 10-9) in diabetics compared to controls and increased the risk of diabetes by 3.02 and 2.088 respectively. Transcript levels of IL1B were significantly higher (p<0.0001) in patients as compared to controls. Genotype-phenotype correlation of IL1B polymorphism did not show any association with its higher transcript levels. In addition, NPY +1128 T/C polymorphism was found to be associated with increased plasma LDL levels (p = 0.01). The present study provides an evidence for a strong correlation between structural and promoter polymorphisms of NPY gene and upregulation of IL1B transcript levels with susceptibility to TIID and altering the lipid metabolism in Gujarat population.

  19. Association of Neuropeptide Y (NPY), Interleukin-1B (IL1B) Genetic Variants and Correlation of IL1B Transcript Levels with Vitiligo Susceptibility

    Science.gov (United States)

    Laddha, Naresh C.; Dwivedi, Mitesh; Mansuri, Mohmmad Shoab; Singh, Mala; Patel, Hetanshi H.; Agarwal, Nishtha; Shah, Anish M.; Begum, Rasheedunnisa

    2014-01-01

    Background Vitiligo is a depigmenting disorder resulting from loss of functional melanocytes in the skin. NPY plays an important role in induction of immune response by acting on a variety of immune cells. NPY synthesis and release is governed by IL1B. Moreover, genetic variability in IL1B is reported to be associated with elevated NPY levels. Objectives Aim of the present study was to explore NPY promoter −399T/C (rs16147) and exon2 +1128T/C (rs16139) polymorphisms as well as IL1B promoter −511C/T (rs16944) polymorphism and to correlate IL1B transcript levels with vitiligo. Methods PCR-RFLP method was used to genotype NPY -399T/C SNP in 454 patients and 1226 controls; +1128T/C SNP in 575 patients and 1279 controls and IL1B −511C/T SNP in 448 patients and 785 controls from Gujarat. IL1B transcript levels in blood were also assessed in 105 controls and 95 patients using real-time PCR. Results Genotype and allele frequencies for NPY −399T/C, +1128T/C and IL1B −511C/T SNPs differed significantly (pvitiligo by 2.3 fold (pvitiligo (p = 0.015), also in female patients than male patients (p = 0.026). Genotype-phenotype correlation showed moderate association of IL1B -511C/T polymorphism with higher IL1B transcript levels. Trend analysis revealed significant difference between patients and controls for IL1B transcript levels with respect to different genotypes. Conclusion Our results suggest that NPY −399T/C, +1128T/C and IL1B −511C/T polymorphisms are associated with vitiligo and IL1B −511C/T SNP influences its transcript levels leading to increased risk for vitiligo in Gujarat population. Up-regulation of IL1B transcript in patients advocates its possible role in autoimmune pathogenesis of vitiligo. PMID:25221996

  20. Molecular cloning and transcriptional analysis of a NPY receptor-like in common Chinese cuttlefish Sepiella japonica

    Science.gov (United States)

    Yang, Jingwen; Xu, Yuchao; Xu, Ke; Ping, Hongling; Shi, Huilai; Lü, Zhenming; Wu, Changwen; Wang, Tianming

    2017-08-01

    Neuropeptide Y (NPY) has a pivotal role in the regulation of many physiological processes. In this study, the gene encoding a NPY receptor-like from the common Chinese cuttlefish Sepiella japonica (SjNPYR-like) was identified and characterized. The full-length SjNPYR-like cDNA was cloned containing a 492-bp of 5' untranslated region (UTR), 1 182 bp open reading frame (ORF) encoding a protein of 393 amino acid residues, and 228 bp of 3' UTR. The putative protein was predicted to have a molecular weight of 45.54 kDa and an isoelectric point (pI) of 8.13. By informatic analyses, SjNPYR-like was identified as belonging to the class A G protein coupled receptor (GPCR) family (the rhodopsin-type). The amino acid sequence contained 12 potential phosphorylation sites and five predicted N-linked glycosylation sites. Multiple sequence alignment and 3D structure modeling were conducted to clarify SjNPYR bioinformatics characteristics. Phylogenetic analysis identifies it as an NPYR with identity of 33% to Lymnaea stagnalis NPFR. Transmembrane properties of SjNPYR-like were demonstrated in vitro using HEK293 cells and the pEGFP-N1 plasmid. Relative quantification of SjNPYR-like mRNA level confirmed a high level expression and broad distribution of SjNPYR - like in various tissues of female S. japonica. In addition, the transcriptional profile of SjNPYR - like in the brain, liver, and ovary during gonadal development was analyzed. The results provide basic understanding on the molecular characteristics of SjNPYR-like and its potentially physical functions.

  1. The tyrosine kinase receptor Tyro3 enhances lifespan and neuropeptide Y (Npy neuron survival in the mouse anorexia (anx mutation

    Directory of Open Access Journals (Sweden)

    Dennis Y. Kim

    2017-05-01

    Full Text Available Severe appetite and weight loss define the eating disorder anorexia nervosa, and can also accompany the progression of some neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS. Although acute loss of hypothalamic neurons that produce appetite-stimulating neuropeptide Y (Npy and agouti-related peptide (Agrp in adult mice or in mice homozygous for the anorexia (anx mutation causes aphagia, our understanding of the factors that help maintain appetite regulatory circuitry is limited. Here we identify a mutation (C19T that converts an arginine to a tryptophan (R7W in the TYRO3 protein tyrosine kinase 3 (Tyro3 gene, which resides within the anx critical interval, as contributing to the severity of anx phenotypes. Our observation that, like Tyro3−/− mice, anx/anx mice exhibit abnormal secondary platelet aggregation suggested that the C19T Tyro3 variant might have functional consequences. Tyro3 is expressed in the hypothalamus and other brain regions affected by the anx mutation, and its mRNA localization appeared abnormal in anx/anx brains by postnatal day 19 (P19. The presence of wild-type Tyro3 transgenes, but not an R7W-Tyro3 transgene, doubled the weight and lifespans of anx/anx mice and near-normal numbers of hypothalamic Npy-expressing neurons were present in Tyro3-transgenic anx/anx mice at P19. Although no differences in R7W-Tyro3 signal sequence function or protein localization were discernible in vitro, distribution of R7W-Tyro3 protein differed from that of Tyro3 protein in the cerebellum of transgenic wild-type mice. Thus, R7W-Tyro3 protein localization deficits are only detectable in vivo. Further analyses revealed that the C19T Tyro3 mutation is present in a few other mouse strains, and hence is not the causative anx mutation, but rather an anx modifier. Our work shows that Tyro3 has prosurvival roles in the appetite regulatory circuitry and could also provide useful insights towards the development of interventions

  2. Aberrant methylation of NPY, PENK, and WIF1 as a promising marker for blood-based diagnosis of colorectal cancer

    KAUST Repository

    Roperch, J.-P.

    2013-12-01

    Background: DNA methylation is a well-known epigenetic mechanism involved in epigenetic gene regulation. Several genes were reported hypermethylated in CRC, althought no gene marker was proven to be individually of sufficient sensitivity or specificity in routine clinical practice. Here, we identified novel epigenetic markers and assessed their combined use for diagnostic accuracy.Methods: We used methylation arrays on samples from several effluents to characterize methylation profiles in CRC samples and controls, as established by colonoscopy and pathology findings, and selected two differentially methylated candidate epigenetic genes (NPY, PENK). To this gene panel we added WIF, on the basis of being reported in literature as silenced by promoter hypermethylation in several cancers, including CRC. We measured their methylation degrees by quantitative multiplex-methylation specific PCR (QM-MSP) on 15 paired carcinomas and adjacent non-cancerous colorectal tissues and we subsequently performed a clinical validation on two different series of 266 serums, subdivided in 32 CRC, 26 polyps, 47 other cancers and 161 with normal colonoscopy. We assessed the results by receiver operating characteristic curve (ROC), using cumulative methylation index (CMI) as variable threshold.Results: We obtained CRC detection on tissues with both sensitivity and specificity of 100%. On serum CRC samples, we obtained sensitivity/specificity values of, e.g., 87%/80%, 78%/90% and 59%/95%, and negative predictive value/positive predictive value figures of 97%/47%, 95%/61% and 92%/70%. On serum samples from other cancers we obtained sensitivity/specificity of, e.g, 89%/25%, 43%/80% and 28%/91%.Conclusions: We showed the potential of NPY, PENK, and WIF1 as combined epigenetic markers for CRC diagnosis, both in tissue and serum and tested their use as serum biomarkers in other cancers. We optimized a QM-MSP for simultaneously quantifying their methylation levels. Our assay can be an effective

  3. Aberrant methylation of NPY, PENK, and WIF1 as a promising marker for blood-based diagnosis of colorectal cancer

    KAUST Repository

    Roperch, J.-P.; Incitti, R.; Forbin, S.; Bard, F.; Mansour, H.; Mesli, F.; Baumgaertner, I.; Brunetti, F.; Sobhani, I.

    2013-01-01

    Background: DNA methylation is a well-known epigenetic mechanism involved in epigenetic gene regulation. Several genes were reported hypermethylated in CRC, althought no gene marker was proven to be individually of sufficient sensitivity or specificity in routine clinical practice. Here, we identified novel epigenetic markers and assessed their combined use for diagnostic accuracy.Methods: We used methylation arrays on samples from several effluents to characterize methylation profiles in CRC samples and controls, as established by colonoscopy and pathology findings, and selected two differentially methylated candidate epigenetic genes (NPY, PENK). To this gene panel we added WIF, on the basis of being reported in literature as silenced by promoter hypermethylation in several cancers, including CRC. We measured their methylation degrees by quantitative multiplex-methylation specific PCR (QM-MSP) on 15 paired carcinomas and adjacent non-cancerous colorectal tissues and we subsequently performed a clinical validation on two different series of 266 serums, subdivided in 32 CRC, 26 polyps, 47 other cancers and 161 with normal colonoscopy. We assessed the results by receiver operating characteristic curve (ROC), using cumulative methylation index (CMI) as variable threshold.Results: We obtained CRC detection on tissues with both sensitivity and specificity of 100%. On serum CRC samples, we obtained sensitivity/specificity values of, e.g., 87%/80%, 78%/90% and 59%/95%, and negative predictive value/positive predictive value figures of 97%/47%, 95%/61% and 92%/70%. On serum samples from other cancers we obtained sensitivity/specificity of, e.g, 89%/25%, 43%/80% and 28%/91%.Conclusions: We showed the potential of NPY, PENK, and WIF1 as combined epigenetic markers for CRC diagnosis, both in tissue and serum and tested their use as serum biomarkers in other cancers. We optimized a QM-MSP for simultaneously quantifying their methylation levels. Our assay can be an effective

  4. POMC and NPY mRNA expression during development is increased in rat offspring brain from mothers fed with a high fat diet.

    Science.gov (United States)

    Klein, Marianne Orlandini; MacKay, Harry; Edwards, Alexander; Park, Su-Bin; Kiss, Ana Carolina Inhasz; Felicio, Luciano Freitas; Abizaid, Alfonso

    2018-02-01

    Developmental programing is influenced by perinatal nutrition and it has long-lasting impacts on adult metabolism in the offspring. In particular, maternal high fat diet has been associated with increased risk of obesity and metabolic disorders during adulthood in the descendants. These effects may be due to the effects of the high fat diet on the development of the systems that regulate food intake and energy balance in the offspring hypothalamus. The arcuate nucleus (ARC) may be a particularly sensitive region to it as this nucleus contains the POMC and AgRP/NPY neurons that integrate the melanocortin system. Thus, the aim of this study was to investigate the effects of maternal high fat diet during pregnancy on the transcription factors that regulate hypothalamic development in the offspring as a potential mechanism that may result in altered neuronal expression of POMC, NPY and/or AgRP. To this end, pregnant females exposed to high fat diet (60% fat diet since day 0 of pregnancy) or standard rat chow were sacrificed on days 12, 14, 16 and 18 of gestation to obtain brains from their developing fetuses and examine the mRNA expression of transcription factors associated with the development of cells in the ARC. Results show that, while no changes in transcription factor expression between groups were observed, POMC and NPY mRNA expression were higher on embryonic day 18 in the high fat group. These results suggest that POMC and NPY expression are altered by in utero exposure to a high fat diet, but these changes in gene expression are not associated with changes in the expression of transcription factors known to determine the fate of ARC cells. Copyright © 2017 ISDN. Published by Elsevier Ltd. All rights reserved.

  5. Communicating polar science to the general public: sharing the social media experience of @OceanSeaIceNPI

    Science.gov (United States)

    Rösel, Anja; Pavlov, Alexey K.; Granskog, Mats A.; Gerland, Sebastian; Meyer, Amelie; Hudson, Stephen R.; King, Jennifer; Itkin, Polona; Cohen, Lana; Dodd, Paul; de Steur, Laura

    2016-04-01

    The findings of climate science need to be communicated to the general public. Researchers are encouraged to do so by journalists, policy-makers and funding agencies and many of us want to become better science communicators. But how can we do this at the lab or small research group level without specifically allocated resources in terms of funds and communication officers? And how do we sustain communication on a regular basis and not just during the limited lifetime of a specific project? One of the solutions is to use the emerging platform of social media, which has become a powerful and inexpensive tool for communicating science to different target audiences. Many research institutions and individual researchers are already advanced users of social media, but small research groups and labs remain underrepresented. The group of oceanographers, sea ice and atmospheric scientists at the Norwegian Polar Institute (@OceanSeaIceNPI( will share our experiences developing and maintaining researcher-driven outreach for over a year through Instagram, Twitter and Facebook. We will present our solutions to some of the practical considerations such as identifying key target groups, defining the framework for sharing responsibilities and interactions within the research group, and choosing an up-to-date and appropriate social medium. By sharing this information, we aim to inspire and assist other research groups and labs in conducting their own effective science communication.

  6. Involvement of CD36 in Modulating the Decrease of NPY and AgRP Induced by Acute Palmitic Acid Stimulation in N1E-115 Cells

    Directory of Open Access Journals (Sweden)

    Yan Ma

    2017-06-01

    Full Text Available Central nervous system (CNS fatty acid sensing plays an important role in the regulation of food intake, and palmitic acid (PA is the most important long chain fatty acid (LCFA in the mammalian diet. To explore the effect of PA on central neuropeptide expression and the role of the cluster of the differentiation of 36 (CD36 in the process, N1E-115 cells were cultured with PA in the presence or absence of sulfosuccinimidyl-oleate (SSO, a CD36 inhibitor. Results showed that 10 μmol/L PA significantly reduced NPY and AgRP mRNA expression after 20 min of exposure, while the expression of CD36 was upregulated. The presence of SSO significantly attenuated the decrease of NPY and AgRP expression that was induced by PA alone, although no notable effect on PA- induced CD36 gene expression was observed. In conclusion, our study suggests the involvement of CD36 in the PA-induced decrease of NPY and AgRP in N1E-115 cells.

  7. Novel Cyclotron-Based Radiometal Production

    International Nuclear Information System (INIS)

    DeGrado, Timothy R.

    2013-01-01

    Accomplishments: (1) Construction of prototype solution target for radiometal production; (2) Testing of prototype target for production of following isotopes: a. Zr-89. Investigation of Zr-89 production from Y-89 nitrate solution. i. Defined problems of gas evolution and salt precipitation. ii. Solved problem of precipitation by addition of nitric acid. iii. Solved gas evolution problem with addition of backpressure regulator and constant degassing of target during irradiations. iv. Investigated effects of Y-89 nitrate concentration and beam current. v. Published abstracts at SNM and ISRS meetings; (3) Design of 2nd generation radiometal solution target. a. Included reflux chamber and smaller target volume to conserve precious target materials. b. Included aluminum for prototype and tantalum for working model. c. Included greater varicosities for improved heat transfer; and, (4) Construction of 2nd generation radiometal solution target started

  8. Activations of c-fos/c-jun signaling are involved in the modulation of hypothalamic superoxide dismutase (SOD) and neuropeptide Y (NPY) gene expression in amphetamine-mediated appetite suppression

    International Nuclear Information System (INIS)

    Hsieh, Y.-S.; Yang, S.-F.; Chiou, H.-L.; Kuo, D.-Y.

    2006-01-01

    Amphetamine (AMPH) is known as an anorectic agent. The mechanism underlying the anorectic action of AMPH has been attributed to its inhibitory action on hypothalamic neuropeptide Y (NPY), an appetite stimulant in the brain. This study was aimed to examine the molecular mechanisms behind the anorectic effect of AMPH. Results showed that AMPH treatment decreased food intake, which was correlated with changes of NPY mRNA level, but increased c-fos, c-jun and superoxide dismutase (SOD) mRNA levels in hypothalamus. To determine if c-fos or c-jun was involved in the anorectic response of AMPH, infusions of antisense oligonucleotide into the brain were performed at 1 h before daily AMPH treatment in freely moving rats, and the results showed that c-fos or c-jun knockdown could block this anorectic response and restore NPY mRNA level. Moreover, c-fos or c-jun knockdown could partially block SOD mRNA level that might involve in the modulation of NPY gene expression. It was suggested that c-fos/c-jun signaling might involve in the central regulation of AMPH-mediated feeding suppression via the modulation of NPY gene expression

  9. The Ontogeny and Brain Distribution Dynamics of the Appetite Regulators NPY, CART and pOX in Larval Atlantic Cod (Gadus morhua L.).

    Science.gov (United States)

    Le, Hoang T M D; Angotzi, Anna Rita; Ebbesson, Lars O E; Karlsen, Ørjan; Rønnestad, Ivar

    2016-01-01

    Similar to many marine teleost species, Atlantic cod undergo remarkable physiological changes during the early life stages with concurrent and profound changes in feeding biology and ecology. In contrast to the digestive system, very little is known about the ontogeny and the localization of the centers that control appetite and feed ingestion in the developing brain of fish. We examined the expression patterns of three appetite regulating factors (orexigenic: neuropeptide Y, NPY; prepro-orexin, pOX and anorexigenic: cocaine- and amphetamine-regulated transcript, CART) in discrete brain regions of developing Atlantic cod using chromogenic and double fluorescent in situ hybridization. Differential temporal and spatial expression patterns for each appetite regulator were found from first feeding (4 days post hatch; dph) to juvenile stage (76 dph). Neurons expressing NPY mRNA were detected in the telencephalon (highest expression), diencephalon, and optic tectum from 4 dph onward. CART mRNA expression had a wider distribution along the anterior-posterior brain axis, including both telencephalon and diencephalon from 4 dph. From 46 dph, CART transcripts were also detected in the olfactory bulb, region of the nucleus of medial longitudinal fascicle, optic tectum and midbrain tegmentum. At 4 and 20 dph, pOX mRNA expression was exclusively found in the preoptic region, but extended to the hypothalamus at 46 and 76 dph. Co-expression of both CART and pOX genes were also observed in several hypothalamic neurons throughout larval development. Our results show that both orexigenic and anorexigenic factors are present in the telencephalon, diencephalon and mesencephalon in cod larvae. The telencephalon mostly contains key factors of hunger control (NPY), while the diencephalon, and particularly the hypothalamus may have a more complex role in modulating the multifunctional control of appetite in this species. As the larvae develop, the overall progression in temporal and

  10. On the regulatory functions of neuropeptide Y (NPY) with respect to vascular resistance and exocrine and endocrine secretion in the pig pancreas

    DEFF Research Database (Denmark)

    Holst, J J; Orskov, C; Knuhtsen, S

    1989-01-01

    We compared the effects of electrical stimulation of the splanchnic nerves and infusions of neuropeptide Y, noradrenaline or a combination of the two on pancreatic vascular resistance and exocrine and endocrine secretion. For these studies we used isolated perfused pig pancreas with preserved...... splanchnic nerve supply. The exocrine secretion was stimulated with physiological concentrations of secretin and cholecystokinin octapeptide. Noradrenaline and NPY at 10(-8) M both increased pancreatic perfusion pressure. Their effects were additive and similar in magnitude to that of electrical stimulation...

  11. A natural variant of obestatin, Q90L, inhibits ghrelin's action on food intake and GH secretion and targets NPY and GHRH neurons in mice.

    Directory of Open Access Journals (Sweden)

    Rim Hassouna

    Full Text Available BACKGROUND: Ghrelin and obestatin are two gut-derived peptides originating from the same ghrelin/obestatin prepropeptide gene (GHRL. While ghrelin stimulates growth hormone (GH secretion and food intake and inhibits γ-aminobutyric-acid synaptic transmission onto GHRH (Growth Hormone Releasing Hormone neurons, obestatin blocks these effects. In Humans, GHRL gene polymorphisms have been associated with pathologies linked to an unbalanced energy homeostasis. We hypothesized that one polymorphism located in the obestatin sequence (Q to L substitution in position 90 of the ghrelin/obestatin prepropeptide, rs4684677 may impact on the function of obestatin. In the present study, we tested the activity of native and Q90L obestatin to modulate ghrelin-induced food intake, GH secretion, cFos activity in GHRH and Neuropeptide Y (NPY neurons and γ-aminobutyric-acid activity onto GHRH neurons. METHODOLOGY/PRINCIPAL FINDINGS: Food intake, GH secretion and electrophysiological recordings were assessed in C57BL/6 mice. cFos activity was measured in NPY-Renilla-GFP and GHRH-eGFP mice. Mice received saline, ghrelin or ghrelin combined to native or Q90L obestatin (30 nmol each in the early light phase. Ghrelin stimulation of food intake and GH secretion varied considerably among individual mice with 59-77% eliciting a robust response. In these high-responders, ghrelin-induced food intake and GH secretion were reduced equally by native and Q90L obestatin. In contrast to in vivo observations, Q90L was slightly more efficient than native obestatin in inhibiting ghrelin-induced cFos activation within the hypothalamic arcuate nucleus and the nucleus tractus solitarius of the brainstem. After ghrelin injection, 26% of NPY neurons in the arcuate nucleus expressed cFos protein and this number was significantly reduced by co-administration of Q90L obestatin. Q90L was also more potent that native obestatin in reducing ghrelin-induced inhibition of

  12. A natural variant of obestatin, Q90L, inhibits ghrelin's action on food intake and GH secretion and targets NPY and GHRH neurons in mice.

    Science.gov (United States)

    Hassouna, Rim; Zizzari, Philippe; Viltart, Odile; Yang, Seung-Kwon; Gardette, Robert; Videau, Catherine; Badoer, Emilio; Epelbaum, Jacques; Tolle, Virginie

    2012-01-01

    Ghrelin and obestatin are two gut-derived peptides originating from the same ghrelin/obestatin prepropeptide gene (GHRL). While ghrelin stimulates growth hormone (GH) secretion and food intake and inhibits γ-aminobutyric-acid synaptic transmission onto GHRH (Growth Hormone Releasing Hormone) neurons, obestatin blocks these effects. In Humans, GHRL gene polymorphisms have been associated with pathologies linked to an unbalanced energy homeostasis. We hypothesized that one polymorphism located in the obestatin sequence (Q to L substitution in position 90 of the ghrelin/obestatin prepropeptide, rs4684677) may impact on the function of obestatin. In the present study, we tested the activity of native and Q90L obestatin to modulate ghrelin-induced food intake, GH secretion, cFos activity in GHRH and Neuropeptide Y (NPY) neurons and γ-aminobutyric-acid activity onto GHRH neurons. Food intake, GH secretion and electrophysiological recordings were assessed in C57BL/6 mice. cFos activity was measured in NPY-Renilla-GFP and GHRH-eGFP mice. Mice received saline, ghrelin or ghrelin combined to native or Q90L obestatin (30 nmol each) in the early light phase. Ghrelin stimulation of food intake and GH secretion varied considerably among individual mice with 59-77% eliciting a robust response. In these high-responders, ghrelin-induced food intake and GH secretion were reduced equally by native and Q90L obestatin. In contrast to in vivo observations, Q90L was slightly more efficient than native obestatin in inhibiting ghrelin-induced cFos activation within the hypothalamic arcuate nucleus and the nucleus tractus solitarius of the brainstem. After ghrelin injection, 26% of NPY neurons in the arcuate nucleus expressed cFos protein and this number was significantly reduced by co-administration of Q90L obestatin. Q90L was also more potent that native obestatin in reducing ghrelin-induced inhibition of γ-aminobutyric-acid synaptic transmission onto GHRH neurons. These data support

  13. A Natural Variant of Obestatin, Q90L, Inhibits Ghrelin's Action on Food Intake and GH Secretion and Targets NPY and GHRH Neurons in Mice

    Science.gov (United States)

    Hassouna, Rim; Zizzari, Philippe; Viltart, Odile; Yang, Seung-Kwon; Gardette, Robert; Videau, Catherine; Badoer, Emilio; Epelbaum, Jacques; Tolle, Virginie

    2012-01-01

    Background Ghrelin and obestatin are two gut-derived peptides originating from the same ghrelin/obestatin prepropeptide gene (GHRL). While ghrelin stimulates growth hormone (GH) secretion and food intake and inhibits γ-aminobutyric-acid synaptic transmission onto GHRH (Growth Hormone Releasing Hormone) neurons, obestatin blocks these effects. In Humans, GHRL gene polymorphisms have been associated with pathologies linked to an unbalanced energy homeostasis. We hypothesized that one polymorphism located in the obestatin sequence (Q to L substitution in position 90 of the ghrelin/obestatin prepropeptide, rs4684677) may impact on the function of obestatin. In the present study, we tested the activity of native and Q90L obestatin to modulate ghrelin-induced food intake, GH secretion, cFos activity in GHRH and Neuropeptide Y (NPY) neurons and γ-aminobutyric-acid activity onto GHRH neurons. Methodology/Principal findings Food intake, GH secretion and electrophysiological recordings were assessed in C57BL/6 mice. cFos activity was measured in NPY-Renilla-GFP and GHRH-eGFP mice. Mice received saline, ghrelin or ghrelin combined to native or Q90L obestatin (30 nmol each) in the early light phase. Ghrelin stimulation of food intake and GH secretion varied considerably among individual mice with 59–77% eliciting a robust response. In these high-responders, ghrelin-induced food intake and GH secretion were reduced equally by native and Q90L obestatin. In contrast to in vivo observations, Q90L was slightly more efficient than native obestatin in inhibiting ghrelin-induced cFos activation within the hypothalamic arcuate nucleus and the nucleus tractus solitarius of the brainstem. After ghrelin injection, 26% of NPY neurons in the arcuate nucleus expressed cFos protein and this number was significantly reduced by co-administration of Q90L obestatin. Q90L was also more potent that native obestatin in reducing ghrelin-induced inhibition of γ-aminobutyric-acid synaptic

  14. The Ontogeny and Brain Distribution Dynamics of the Appetite Regulators NPY, CART and pOX in Larval Atlantic Cod (Gadus morhua L..

    Directory of Open Access Journals (Sweden)

    Hoang T M D Le

    Full Text Available Similar to many marine teleost species, Atlantic cod undergo remarkable physiological changes during the early life stages with concurrent and profound changes in feeding biology and ecology. In contrast to the digestive system, very little is known about the ontogeny and the localization of the centers that control appetite and feed ingestion in the developing brain of fish. We examined the expression patterns of three appetite regulating factors (orexigenic: neuropeptide Y, NPY; prepro-orexin, pOX and anorexigenic: cocaine- and amphetamine-regulated transcript, CART in discrete brain regions of developing Atlantic cod using chromogenic and double fluorescent in situ hybridization. Differential temporal and spatial expression patterns for each appetite regulator were found from first feeding (4 days post hatch; dph to juvenile stage (76 dph. Neurons expressing NPY mRNA were detected in the telencephalon (highest expression, diencephalon, and optic tectum from 4 dph onward. CART mRNA expression had a wider distribution along the anterior-posterior brain axis, including both telencephalon and diencephalon from 4 dph. From 46 dph, CART transcripts were also detected in the olfactory bulb, region of the nucleus of medial longitudinal fascicle, optic tectum and midbrain tegmentum. At 4 and 20 dph, pOX mRNA expression was exclusively found in the preoptic region, but extended to the hypothalamus at 46 and 76 dph. Co-expression of both CART and pOX genes were also observed in several hypothalamic neurons throughout larval development. Our results show that both orexigenic and anorexigenic factors are present in the telencephalon, diencephalon and mesencephalon in cod larvae. The telencephalon mostly contains key factors of hunger control (NPY, while the diencephalon, and particularly the hypothalamus may have a more complex role in modulating the multifunctional control of appetite in this species. As the larvae develop, the overall progression in

  15. Neutron spectrum determination of d(20)+Be source reaction by the dosimetry foils method

    Science.gov (United States)

    Stefanik, Milan; Bem, Pavel; Majerle, Mitja; Novak, Jan; Simeckova, Eva

    2017-11-01

    The cyclotron-based fast neutron generator with the thick beryllium target operated at the NPI Rez Fast Neutron Facility is primarily designed for the fast neutron production in the p+Be source reaction at 35 MeV. Besides the proton beam, the isochronous cyclotron U-120M at the NPI provides the deuterons in the energy range of 10-20 MeV. The experiments for neutron field investigation from the deuteron bombardment of thick beryllium target at 20 MeV were performed just recently. For the neutron spectrum measurement of the d(20)+Be source reaction, the dosimetry foils activation method was utilized. Neutron spectrum reconstruction from resulting reaction rates was performed using the SAND-II unfolding code and neutron cross-sections from the EAF-2010 nuclear data library. Obtained high-flux white neutron field from the d(20)+Be source is useful for the intensive irradiation experiments and cross-section data validation.

  16. Fast reactors

    International Nuclear Information System (INIS)

    Vasile, A.

    2001-01-01

    Fast reactors have capacities to spare uranium natural resources by their breeding property and to propose solutions to the management of radioactive wastes by limiting the inventory of heavy nuclei. This article highlights the role that fast reactors could play for reducing the radiotoxicity of wastes. The conversion of 238 U into 239 Pu by neutron capture is more efficient in fast reactors than in light water reactors. In fast reactors multi-recycling of U + Pu leads to fissioning up to 95% of the initial fuel ( 238 U + 235 U). 2 strategies have been studied to burn actinides: - the multi-recycling of heavy nuclei is made inside the fuel element (homogeneous option); - the unique recycling is made in special irradiation targets placed inside the core or at its surroundings (heterogeneous option). Simulations have shown that, for the same amount of energy produced (400 TWhe), the mass of transuranium elements (Pu + Np + Am + Cm) sent to waste disposal is 60,9 Kg in the homogeneous option and 204.4 Kg in the heterogeneous option. Experimental programs are carried out in Phenix and BOR60 reactors in order to study the feasibility of such strategies. (A.C.)

  17. Fast ejendom

    DEFF Research Database (Denmark)

    Pagh, Peter

    Bogen omfatter en gennemgang af lovgivning, praksis og teori vedrørende køb af fast ejendom og offentligretlig og privatretlig regulering. Bogen belyser bl.a. de privatretlige emner: købers misligholdelsesbeføjelser, servitutter, naboret, hævd og erstatningsansvar for miljøskader samt den...

  18. Improving access to interventions among mothers screened positive for post-partum depression (PPD) at National Programme on Immunization (NPI) clinics in south-western and south-eastern Nigeria - A service development report.

    Science.gov (United States)

    Bakare, Muideen O; Bello-Mojeed, Mashudat A; Munir, Kerim M; Duduyemi, Olaniyi O; Orovwigho, Andrew O; Odetunde, Odutola I; Taiwo, Olufemi G; Olofinlade, Jushua A; Omotoso, Olakunle N; Famurewa, Olayinka H; Omolabi, Oladipupo O; Jejeloye, Adebayo O

    2017-01-01

    We investigate the possibility of improving access to interventions among mothers screened positive for post-partum depression (PPD) at National Programme on Immunization (NPI) clinics randomly selected from Lagos and Enugu States in south-western and south-eastern Nigeria respectively. The principle of human centred design was employed by engaging the mothers screened positive for PPD to be part of the decision making regarding their further assessment and intervention services. The study brought intervention services to primary healthcare centre at the NPI clinics. Improvement in willingness to seek interventions was observed among the mothers screened positive for PPD in this study when compared to our observation in a previous report, where mothers diagnosed with PPD were referred and requested to visit a mental health facility closer to their NPI clinics for further assessment and interventions (95.2% versus 33.7%). Interventional services for the mothers diagnosed with PPD also impact positively on the growth parameters of their infants on follow-up. Principle of human centred design improved access to intervention services among the mothers and infants studied. NPI clinics at primary healthcare level would provide appropriate forum for early screening of mothers for PPD and interventions in low-resource setting like Nigeria. There would be improvement in maternal and child health coverage if the Nigerian Government can adapt human centred design principles employed in this study nationwide.

  19. N(G)-Acyl-argininamides as NPY Y(1) receptor antagonists: Influence of structurally diverse acyl substituents on stability and affinity.

    Science.gov (United States)

    Weiss, Stefan; Keller, Max; Bernhardt, Günther; Buschauer, Armin; König, Burkhard

    2010-09-01

    N(G)-Acylated argininamides, covering a broad range of lipophilicity (calculated logD values: -1.8-12.5), were synthesized and investigated for NPY Y(1) receptor (Y(1)R) antagonism, Y(1)R affinity and stability in buffer (N(G)-deacylation, yielding BIBP 3226). Broad structural variation of substituents was tolerated. The K(i) (binding) and K(b) values (Y(1)R antagonism) varied from low nM to one-digit muM. Most of the compounds proved to be sufficiently stable at pH 7.4 over 90min to determine reliable pharmacological data in vitro. Exceptionally high instability was detected when a succinyl moiety was attached to the guanidine, probably, due to an intramolecular cleavage mechanism. Copyright 2010 Elsevier Ltd. All rights reserved.

  20. Lowering glucose level elevates [Ca2+]i in hypothalamic arcuate nucleus NPY neurons through P/Q-type Ca2+ channel activation and GSK3β inhibition

    Science.gov (United States)

    Chen, Yu; Zhou, Jun; Xie, Na; Huang, Chao; Zhang, Jun-qi; Hu, Zhuang-li; Ni, Lan; Jin, You; Wang, Fang; Chen, Jian-guo; Long, Li-hong

    2012-01-01

    Aim: To identify the mechanisms underlying the elevation of intracellular Ca2+ level ([Ca2+]i) induced by lowering extracellular glucose in rat hypothalamic arcuate nucleus NPY neurons. Methods: Primary cultures of hypothalamic arcuate nucleus (ARC) neurons were prepared from Sprague-Dawley rats. NPY neurons were identified with immunocytochemical method. [Ca2+]i was measured using fura-2 AM. Ca2+ current was recorded using whole-cell patch clamp recording. AMPK and GSK3β levels were measured using Western blot assay. Results: Lowering glucose level in the medium (from 10 to 1 mmol/L) induced a transient elevation of [Ca2+]i in ARC neurons, but not in hippocampal and cortical neurons. The low-glucose induced elevation of [Ca2+]i in ARC neurons depended on extracellular Ca2+, and was blocked by P/Q-type Ca2+channel blocker ω-agatoxin TK (100 nmol/L), but not by L-type Ca2+ channel blocker nifedipine (10 μmol/L) or N-type Ca2+channel blocker ω-conotoxin GVIA (300 nmol/L). Lowering glucose level increased the peak amplitude of high voltage-activated Ca2+ current in ARC neurons. The low-glucose induced elevation of [Ca2+]i in ARC neurons was blocked by the AMPK inhibitor compound C (20 μmol/L), and enhanced by the GSK3β inhibitor LiCl (10 mmol/L). Moreover, lowering glucose level induced the phosphorylation of AMPK and GSK3β, which was inhibited by compound C (20 μmol/L). Conclusion: Lowering glucose level enhances the activity of P/Q type Ca2+channels and elevates [Ca2+]i level in hypothalamic arcuate nucleus neurons via inhibition of GSK3β. PMID:22504905

  1. Fast tomosynthesis

    International Nuclear Information System (INIS)

    Klotz, E.; Linde, R.; Tiemens, U.; Weiss, H.

    1978-01-01

    A system has been constructed for fast tomosynthesis, whereby X-ray photographs are made of a single layer of an object. Twenty five X-ray tubes illuminate the object simultaneously at different angles. The resulting coded image is decoded by projecting it with a pattern of lenses that have the same form as the pattern of X-ray tubes. The coded image is optically correlated with the pattern of the sources. The scale of this can be adjusted so that the desired layer of the object is portrayed. Experimental results of its use in a hospital are presented. (C.F.)

  2. Corticotropin-releasing factor overexpression in mice abrogates sex differences in body weight, visceral fat, and food intake response to a fast and alters levels of feeding regulatory hormones.

    Science.gov (United States)

    Wang, Lixin; Goebel-Stengel, Miriam; Yuan, Pu-Qing; Stengel, Andreas; Taché, Yvette

    2017-01-01

    Corticotropin-releasing factor overexpressing (CRF-OE) male mice showed an inhibited feeding response to a fast, and lower plasma acyl ghrelin and Fos expression in the arcuate nucleus compared to wild-type (WT) mice. We investigated whether hormones and hypothalamic feeding signals are impaired in CRF-OE mice and the influence of sex. Male and female CRF-OE mice and WT littermates (4-6 months old) fed ad libitum or overnight fasted were assessed for body, adrenal glands and perigonadal fat weights, food intake, plasma hormones, blood glucose, and mRNA hypothalamic signals. Under fed conditions, compared to WT, CRF-OE mice have increased adrenal glands and perigonadal fat weight, plasma corticosterone, leptin and insulin, and hypothalamic leptin receptor and decreased plasma acyl ghrelin. Compared to male, female WT mice have lower body and perigonadal fat and plasma leptin but higher adrenal glands weights. CRF-OE mice lost these sex differences except for the adrenals. Male CRF-OE and WT mice did not differ in hypothalamic expression of neuropeptide Y (NPY) and proopiomelanocortin (POMC), while female CRF-OE compared to female WT and male CRF-OE had higher NPY mRNA levels. After fasting, female WT mice lost more body weight and ate more food than male WT, while CRF-OE mice had reduced body weight loss and inhibited food intake without sex difference. In male WT mice, fasting reduced plasma insulin and leptin and increased acyl ghrelin and corticosterone while female WT showed only a rise in corticosterone. In CRF-OE mice, fasting reduced insulin while leptin, acyl ghrelin and corticosterone were unchanged with no sex difference. Fasting blood glucose was higher in CRF-OE with female > male. In WT mice, fasting increased hypothalamic NPY expression in both sexes and decreased POMC only in males, while in CRF-OE mice, NPY did not change, and POMC decreased in males and increased in females. These data indicate that CRF-OE mice have abnormal basal and fasting

  3. The red imported fire ant (Solenopsis invicta Buren kept Y not F: predicted sNPY endogenous ligands deorphanize the short NPF (sNPF receptor.

    Directory of Open Access Journals (Sweden)

    Prati Bajracharya

    Full Text Available Neuropeptides and their receptors play vital roles in controlling the physiology and behavior of animals. Short neuropeptide F (sNPF signaling regulates several physiological processes in insects such as feeding, locomotion, circadian rhythm and reproduction, among others. Previously, the red imported fire ant (Solenopsis invicta sNPF receptor (S. invicta sNPFR, a G protein-coupled receptor, was immunolocalized in queen and worker brain and queen ovaries. Differential distribution patterns of S. invicta sNPFR protein in fire ant worker brain were associated both with worker subcastes and with presence or absence of brood in the colony. However, the cognate ligand for this sNPFR has not been characterized and attempts to deorphanize the receptor with sNPF peptides from other insect species which ended in the canonical sequence LRLRFamide, failed. Receptor deorphanization is an important step to understand the neuropeptide receptor downstream signaling cascade. We cloned the full length cDNA of the putative S. invicta sNPF prepropeptide and identified the putative "sNPF" ligand within its sequence. The peptide ends with an amidated Tyr residue whereas in other insect species sNPFs have an amidated Phe or Trp residue at the C-terminus. We stably expressed the HA-tagged S. invicta sNPFR in CHO-K1 cells. Two S. invicta sNPFs differing at their N-terminus were synthesized that equally activated the sNPFR, SLRSALAAGHLRYa (EC50 = 3.2 nM and SALAAGHLRYa (EC50 = 8.6 nM. Both peptides decreased the intracellular cAMP concentration, indicating signaling through the Gαi-subunit. The receptor was not activated by sNPF peptides from other insect species, honey bee long NPF (NPY or mammalian PYY. Further, a synthesized peptide otherwise identical to the fire ant sequence but in which the C-terminal amidated amino acid residue 'Y' was switched to 'F', failed to activate the sNPFR. This discovery will now allow us to investigate the function of sNPY and

  4. Fast Convolution Module (Fast Convolution Module)

    National Research Council Canada - National Science Library

    Bierens, L

    1997-01-01

    This report describes the design and realisation of a real-time range azimuth compression module, the so-called 'Fast Convolution Module', based on the fast convolution algorithm developed at TNO-FEL...

  5. FAST: FAST Analysis of Sequences Toolbox

    Directory of Open Access Journals (Sweden)

    Travis J. Lawrence

    2015-05-01

    Full Text Available FAST (FAST Analysis of Sequences Toolbox provides simple, powerful open source command-line tools to filter, transform, annotate and analyze biological sequence data. Modeled after the GNU (GNU’s Not Unix Textutils such as grep, cut, and tr, FAST tools such as fasgrep, fascut, and fastr make it easy to rapidly prototype expressive bioinformatic workflows in a compact and generic command vocabulary. Compact combinatorial encoding of data workflows with FAST commands can simplify the documentation and reproducibility of bioinformatic protocols, supporting better transparency in biological data science. Interface self-consistency and conformity with conventions of GNU, Matlab, Perl, BioPerl, R and GenBank help make FAST easy and rewarding to learn. FAST automates numerical, taxonomic, and text-based sorting, selection and transformation of sequence records and alignment sites based on content, index ranges, descriptive tags, annotated features, and in-line calculated analytics, including composition and codon usage. Automated content- and feature-based extraction of sites and support for molecular population genetic statistics makes FAST useful for molecular evolutionary analysis. FAST is portable, easy to install and secure thanks to the relative maturity of its Perl and BioPerl foundations, with stable releases posted to CPAN. Development as well as a publicly accessible Cookbook and Wiki are available on the FAST GitHub repository at https://github.com/tlawrence3/FAST. The default data exchange format in FAST is Multi-FastA (specifically, a restriction of BioPerl FastA format. Sanger and Illumina 1.8+ FastQ formatted files are also supported. FAST makes it easier for non-programmer biologists to interactively investigate and control biological data at the speed of thought.

  6. Fasting and rheumatic diseases

    OpenAIRE

    Mohammad Hassan Jokar

    2015-01-01

    Fasting is one of the important religious practices of Muslims, in which the individuals abstain from eating and drinking from dawn to sunset. Fasting is not obligatory or even not allowed, in case it causes health problems to the fasting individual. Rheumatic diseases are a major group of chronic diseases which can bring about numerous problems while fasting. The aim of this article is to review the impact of Islamic fasting on rheumatic patients, based on the scientific evidences.

  7. The cross-section data from neutron activation experiments on niobium in the NPI p-7Li quasi-monoenergetic neutron field

    Directory of Open Access Journals (Sweden)

    Simakov S.P.

    2010-10-01

    Full Text Available The reaction of protons on 7Li target produces the high-energy quasi- monoenergetic neutron spectrum with the tail to lower energies. Proton energies of 19.8, 25.1, 27.6, 30.1, 32.6, 35.0 and 37.4 MeV were used to obtain quasi-monoenergetic neutrons with energies of 18, 21.6, 24.8, 27.6, 30.3, 32.9 and 35.6 MeV, respectively. Nb cross-section data for neutron energies higher than 22.5 MeV do not exist in the literature. Nb is the important material for fusion applications (IFMIF as well. The variable-energy proton beam of NPI cyclotron is utilized for the production of neutron field using thin lithium target. The carbon backing serves as the beam stopper. The system permits to produce neutron flux density about 109  n/cm2/s in peak at 30 MeV neutron energy. The niobium foils of 15 mm in diameter and approx. 0.75 g weight were activated. The nuclear spectroscopy methods with HPGe detector technique were used to obtain the activities of produced isotopes. The large set of neutron energies used in the experiment allows us to make the complex study of the cross-section values. The reactions (n,2n, (n,3n, (n,4n, (n,He3, (n,α and (n,2nα are studied. The cross-sections data of the (n,4n and (n,2nα are obtained for the first time. The cross-sections of (n,2n and (n,α reactions for higher neutron energies are strongly influenced by low energy tail of neutron spectra. This effect is discussed. The results are compared with the EAF-2007 library.

  8. Metabolic Benefit of Chronic Caloric Restriction and Activation of Hypothalamic AGRP/NPY Neurons in Male Mice Is Independent of Ghrelin

    Science.gov (United States)

    Rogers, Nicole H.; Walsh, Heidi; Alvarez-Garcia, Oscar; Park, Seongjoon; Gaylinn, Bruce; Thorner, Michael O.

    2016-01-01

    Aging is associated with attenuated ghrelin signaling. During aging, chronic caloric restriction (CR) produces health benefits accompanied by enhanced ghrelin production. Ghrelin receptor (GH secretagogue receptor 1a) agonists administered to aging rodents and humans restore the young adult phenotype; therefore, we tested the hypothesis that the metabolic benefits of CR are mediated by endogenous ghrelin. Three month-old male mice lacking ghrelin (Ghrelin−/−) or ghrelin receptor (Ghsr−/−), and their wild-type (WT) littermates were randomly assigned to 2 groups: ad libitum (AL) fed and CR, where 40% food restriction was introduced gradually to allow Ghrelin−/− and Ghsr−/− mice to metabolically adapt and avoid severe hypoglycemia. Twelve months later, plasma ghrelin, metabolic parameters, ambulatory activity, hypothalamic and liver gene expression, as well as body composition were measured. CR increased plasma ghrelin and des-acyl ghrelin concentrations in WT and Ghsr−/− mice. CR of WT, Ghsr−/−, and Ghrelin−/− mice markedly improved metabolic flexibility, enhanced ambulatory activity, and reduced adiposity. Inactivation of Ghrelin or Ghsr had no effect on AL food intake or food anticipatory behavior. In contrast to the widely held belief that endogenous ghrelin regulates food intake, CR increased expression of hypothalamic Agrp and Npy, with reduced expression of Pomc across genotypes. In the AL context, ablation of ghrelin signaling markedly inhibited liver steatosis, which correlated with reduced Pparγ expression and enhanced Irs2 expression. Although CR and administration of GH secretagogue receptor 1a agonists both benefit the aging phenotype, we conclude the benefits of chronic CR are a consequence of enhanced metabolic flexibility independent of endogenous ghrelin or des-acyl ghrelin signaling. PMID:26812158

  9. HCUP Fast Stats

    Data.gov (United States)

    U.S. Department of Health & Human Services — HCUP Fast Stats provides easy access to the latest HCUP-based statistics for health information topics. HCUP Fast Stats uses visual statistical displays in...

  10. Fast food (image)

    Science.gov (United States)

    Fast foods are quick, reasonably priced, and readily available alternatives to home cooking. While convenient and economical for a busy lifestyle, fast foods are typically high in calories, fat, saturated fat, ...

  11. Fast food tips (image)

    Science.gov (United States)

    ... challenge to eat healthy when going to a fast food place. In general, avoiding items that are deep ... challenge to eat healthy when going to a fast food place. In general, avoiding items that are deep ...

  12. Physiology of Ramadan fasting

    OpenAIRE

    Shokoufeh Bonakdaran

    2016-01-01

    Considering the emphasis of Islam on the importance of fasting, Muslims attempt to fast from dawn until sunset during the holy month of Ramadan. Fasting is associated with several benefits for normal and healthy individuals. However, it could pose high risks to the health of diabetic patients due to certain physiological changes. This study aimed to compare the physiological changes associated with fasting in healthy individuals and diabetic patients during Ramadan. Furthermore, we reviewed t...

  13. The prototype fast reactor

    International Nuclear Information System (INIS)

    Broomfield, A.M.

    1985-01-01

    The paper concerns the Prototype Fast Reactor (PFR), which is a liquid metal cooled fast reactor power station, situated at Dounreay, Scotland. The principal design features of a Fast Reactor and the PFR are given, along with key points of operating history, and health and safety features. The role of the PFR in the development programme for commercial reactors is discussed. (U.K.)

  14. The fast reactor

    International Nuclear Information System (INIS)

    1980-02-01

    The subject is discussed as follows: brief description of fast reactors; advantage in conserving uranium resources; experience, in UK and elsewhere, in fast reactor design, construction and operation; safety; production of plutonium, security aspects; consideration of future UK fast reactor programme. (U.K.)

  15. Ramadan, fasting and pregnancy

    DEFF Research Database (Denmark)

    Ahmed, Urfan Zahoor; Lykke, Jacob Alexander

    2014-01-01

    In Islam, the month of Ramadan is a period of fasting lasting 29 or 30 days. Epidemiological studies among Muslims in Denmark have not been conducted, but studies show, that fasting among pregnant Muslim women is common. Fasting does not increase the risk of growth restriction or preterm delivery...

  16. On the terminal homologation of physiologically active peptides as a means of increasing stability in human serum--neurotensin, opiorphin, B27-KK10 epitope, NPY.

    Science.gov (United States)

    Seebach, Dieter; Lukaszuk, Aneta; Patora-Komisarska, Krystyna; Podwysocka, Dominika; Gardiner, James; Ebert, Marc-Olivier; Reubi, Jean Claude; Cescato, Renzo; Waser, Beatrice; Gmeiner, Peter; Hübner, Harald; Rougeot, Catherine

    2011-05-01

    The terminal homologation by CH(2) insertion into the peptides mentioned in the title is described. This involves replacement of the N-terminal amino acid residue by a β(2) - and of the C-terminal amino acid residue by a β(3) -homo-amino acid moiety (β(2) hXaa and β(3) hXaa, resp.; Fig. 1). In this way, the structure of the peptide chain from the N-terminal to the C-terminal stereogenic center is identical, and the modified peptide is protected against cleavage by exopeptidases (Figs. 2 and 3). Neurotensin (NT; 1) and its C-terminal fragment NT(8-13) are ligands of the G-protein-coupled receptors (GPCR) NT1, NT2, NT3, and NT analogs are promising tools to be used in cancer diagnostics and therapy. The affinities of homologated NT analogs, 2b-2e, for NT1 and NT2 receptors were determined by using cell homogenates and tumor tissues (Table 1); in the latter experiments, the affinities for the NT1 receptor are more or less the same as those of NT (0.5-1.3 vs. 0.6 nM). At the same time, one of the homologated NT analogs, 2c, survives in human plasma for 7 days at 37° (Fig. 6). An NMR analysis of NT(8-13) (Tables 2 and 4, and Fig. 8) reveals that this N-terminal NT fragment folds to a turn in CD(3) OH. - In the case of the human analgesic opiorphin (3a), a pentapeptide, and of the HIV-derived B27-KK10 (4a), a decapeptide, terminal homologation (→3b and 4b, resp.) led to a 7- and 70-fold half-life increase in plasma (Fig. 9). With N-terminally homologated NPY, 5c, we were not able to determine serum stability; the peptide consisting of 36 amino acid residues is subject to cleavage by endopetidases. Three of the homologated compounds, 2b, 2c, and 5c, were shown to be agonists (Fig. 7 and 11). A comparison of terminal homologation with other stability-increasing terminal modifications of peptides is performed (Fig. 5), and possible applications of the neurotensin analogs, described herein, are discussed. Copyright © 2011 Verlag Helvetica Chimica

  17. Ramadan, fasting and pregnancy

    DEFF Research Database (Denmark)

    Ahmed, Urfan Zahoor; Lykke, Jacob Alexander

    2014-01-01

    In Islam, the month of Ramadan is a period of fasting lasting 29 or 30 days. Epidemiological studies among Muslims in Denmark have not been conducted, but studies show, that fasting among pregnant Muslim women is common. Fasting does not increase the risk of growth restriction or preterm delivery......, but there are reports of decreased foetal movements. Furthermore, the fasting may have long-term health consequences for the offspring, especially when they reach their middle age. According to Islam and the interpretation, pregnant and breast-feeding women are allowed to postpone the fasting of the month of Ramadan...

  18. Ramadan, faste og graviditet

    DEFF Research Database (Denmark)

    Ahmed, Urfan Zahoor; Lykke, Jacob Alexander

    2014-01-01

    In Islam, the month of Ramadan is a period of fasting lasting 29 or 30 days. Epidemiological studies among Muslims in Denmark have not been conducted, but studies show, that fasting among pregnant Muslim women is common. Fasting does not increase the risk of growth restriction or preterm delivery......, but there are reports of decreased foetal movements. Furthermore, the fasting may have long-term health consequences for the offspring, especially when they reach their middle age. According to Islam and the interpretation, pregnant and breast-feeding women are allowed to postpone the fasting of the month of Ramadan...

  19. The fast breeder reactor

    International Nuclear Information System (INIS)

    Collier, J.

    1990-01-01

    The arguments for and against the fast breeder reactor are debated. The case for the fast reactor is that the world energy demand will increase due to increasing population over the next forty years and that the damage to the global environment from burning fossil fuels which contribute to the greenhouse effect. Nuclear fission is the only large scale energy source which can achieve a cut in the use of carbon based fuels although energy conservation and renewable sources will also be important. Fast reactors produce more energy from uranium than other types of (thermal) reactors such as AGRs and PWRs. Fast reactors would be important from about 2020 onwards especially as by then many thermal reactors will need to be replaced. Fast reactors are also safer than normal reactors. The arguments against fast reactors are largely economic. The cost, especially the capital cost is very high. The viability of the technology is also questioned. (UK)

  20. The fast breeder reactor

    International Nuclear Information System (INIS)

    Davis, D.A.; Baker, M.A.W.; Hall, R.S.

    1990-01-01

    Following submission of written evidence, the Energy Committee members asked questions of three witnesses from the Central Electricity Generating Board and Nuclear Electric (which will be the government owned company running nuclear power stations after privatisation). Both questions and answers are reported verbatim. The points raised include where the responsibility for the future fast reactor programme should lie, with government only or with private enterprise or both and the viability of fast breeder reactors in the future. The case for the fast reactor was stated as essentially strategic not economic. This raised the issue of nuclear cost which has both a construction and a decommissioning element. There was considerable discussion as to the cost of building a European Fast reactor and the cost of the electricity it would generate compared with PWR type reactors. The likely demand for fast reactors will not arrive for 20-30 years and the need to build a fast reactor now is questioned. (UK)

  1. Fast reactors worldwide

    International Nuclear Information System (INIS)

    Hall, R.S.; Vignon, D.

    1985-01-01

    The paper concerns the evolution of fast reactors over the past 30 years, and their present status. Fast reactor development in different countries is described, and the present position, with emphasis on cost reduction and collaboration, is examined. The French development of the fast breeder type reactor is reviewed, and includes: the acquisition of technical skills, the search for competitive costs and the spx2 project, and more advanced designs. Future prospects are also discussed. (U.K.)

  2. Fast breeder reactors

    International Nuclear Information System (INIS)

    Heinzel, V.

    1975-01-01

    The author gives a survey of 'fast breeder reactors'. In detail the process of breeding, the reasons for the development of fast breeders, the possible breeder reactors, the design criteria, fuels, cladding, coolant, and safety aspects are reported on. Design data of some experimental reactors already in operation are summarized in stabular form. 300 MWe Prototype-Reactors SNR-300 and PFR are explained in detail and data of KWU helium-cooled fast breeder reactors are given. (HR) [de

  3. Fast wave current drive

    International Nuclear Information System (INIS)

    Goree, J.; Ono, M.; Colestock, P.; Horton, R.; McNeill, D.; Park, H.

    1985-07-01

    Fast wave current drive is demonstrated in the Princeton ACT-I toroidal device. The fast Alfven wave, in the range of high ion-cyclotron harmonics, produced 40 A of current from 1 kW of rf power coupled into the plasma by fast wave loop antenna. This wave excites a steady current by damping on the energetic tail of the electron distribution function in the same way as lower-hybrid current drive, except that fast wave current drive is appropriate for higher plasma densities

  4. Potential of cyclotron based accelerators for energy production and transmutation

    Energy Technology Data Exchange (ETDEWEB)

    Stammbach, T.; Adam, S.; Fitze, H.R. [Paul Scherrer Institute, Villigen (Switzerland)] [and others

    1995-10-01

    PSI operates a 590 MeV-cyclotron facility for high intensity proton beams for the production of intense beams of pions and muons. The facility, commissioned in 1974, has been partially upgraded and is now operated routinely at a beam current of 1 mA, which corresponds to a beam power of 0.6 MW. At this current, the beam losses in the cyclotron are about 0.02%. By the end of 1995 the authors expect to have 1.5 mA of protons. Extensive theoretical investigations on beam current limitations in isochronous cyclotrons were undertaken. They show that the longitudinal space charge effects dominate. Based on their experience the authors present a preliminary design of a cyclotron scheme that could produce a 10 MW beam as a driver for an {open_quotes}energy amplifier{close_quotes} as proposed by C. Rubbia and his collaborators. The expected efficiency for the conversion of AC into beam power would be about 50% (for the RF-systems only). The beam losses in the cyclotron are expected to be a few {mu}A, leading to a tolerable activation level.

  5. Fast multichannel analyser

    Energy Technology Data Exchange (ETDEWEB)

    Berry, A; Przybylski, M M; Sumner, I [Science Research Council, Daresbury (UK). Daresbury Lab.

    1982-10-01

    A fast multichannel analyser (MCA) capable of sampling at a rate of 10/sup 7/ s/sup -1/ has been developed. The instrument is based on an 8 bit parallel encoding analogue to digital converter (ADC) reading into a fast histogramming random access memory (RAM) system, giving 256 channels of 64 k count capacity. The prototype unit is in CAMAC format.

  6. A fast multichannel analyser

    International Nuclear Information System (INIS)

    Berry, A.; Przybylski, M.M.; Sumner, I.

    1982-01-01

    A fast multichannel analyser (MCA) capable of sampling at a rate of 10 7 s -1 has been developed. The instrument is based on an 8 bit parallel encoding analogue to digital converter (ADC) reading into a fast histogramming random access memory (RAM) system, giving 256 channels of 64 k count capacity. The prototype unit is in CAMAC format. (orig.)

  7. Islamic Fasting and Diabetes

    Directory of Open Access Journals (Sweden)

    Fereidoun Azizi

    2013-07-01

    Full Text Available The aim of this article is to review health-related aspects of Ramadan fasting in normal individuals and diabetics. During fasting days of Ramadan, glucose homeostasis is maintained by meal taken bepore dawn and by liver glycogen stores. Changes in serum lipids are variable and defend on the quality and quantity of food consumption and changes in weight. Compliant, well controlled type 2 diabetics may observe Ramadan fasting; but fasting is not recommended for type 1, non complaint, poorly controlled and pregnant diabetics. Although Ramadan fasting is safe for all healthy individuals and well controlled diabetics, those with uncontrolled diabetics and diabetics with complications should consult physicians and follow scientific recommendations.

  8. Fast Spectrum Reactors

    CERN Document Server

    Todd, Donald; Tsvetkov, Pavel

    2012-01-01

    Fast Spectrum Reactors presents a detailed overview of world-wide technology contributing to the development of fast spectrum reactors. With a unique focus on the capabilities of fast spectrum reactors to address nuclear waste transmutation issues, in addition to the well-known capabilities of breeding new fuel, this volume describes how fast spectrum reactors contribute to the wide application of nuclear power systems to serve the global nuclear renaissance while minimizing nuclear proliferation concerns. Readers will find an introduction to the sustainable development of nuclear energy and the role of fast reactors, in addition to an economic analysis of nuclear reactors. A section devoted to neutronics offers the current trends in nuclear design, such as performance parameters and the optimization of advanced power systems. The latest findings on fuel management, partitioning and transmutation include the physics, efficiency and strategies of transmutation, homogeneous and heterogeneous recycling, in addit...

  9. Fast ejendom III

    DEFF Research Database (Denmark)

    Munk-Hansen, Carsten

    Bogen er det tredje bind af tre planlagte bind om fast ejendom: I Overdragelsen, II Bolighandlen og III Ejerbeføjelsen. Fremstillingens giver et grundigt overblik over centrale områder af en omfattende regulering af fast ejendom, med angivelse af litteratur, hvor læseren kan søge yderligere...... oplysning. En ejer af fast ejendom er på særdeles mange områder begrænset i sin råden sammenlignet med ejeren af et formuegode i almindelighed. Fremstillingen tager udgangspunkt i ejerens perspektiv (fremfor samfundets eller myndighedernes). Både den privatretlige og offentligretlige regulering behandles......, eksempelvis ejendomsdannelsen, servitutter, naboretten, hævd, zoneinddelingen, den fysiske planlægning, beskyttelse af natur, beskyttelse af kultur, forurening fra fast ejendom, erstatning for forurening, jordforurening, ekspropriation, byggeri og adgang til fast ejendom....

  10. Fast fission phenomena

    International Nuclear Information System (INIS)

    Gregoire, Christian.

    1982-03-01

    Experimental studies of fast fission phenomena are presented. The paper is divided into three parts. In the first part, problems associated with fast fission processes are examined in terms of interaction potentials and a dynamic model is presented in which highly elastic collisions, the formation of compound nuclei and fast fission appear naturally. In the second part, a description is given of the experimental methods employed, the observations made and the preliminary interpretation of measurements suggesting the occurence of fast fission processes. In the third part, our dynamic model is incorporated in a general theory of the dissipative processes studied. This theory enables fluctuations associated with collective variables to be calculated. It is applied to highly inelastic collisions, to fast fission and to the fission dynamics of compound nuclei (for which a schematic representation is given). It is with these calculations that the main results of the second part can be interpreted [fr

  11. Valence-delocalization of the mixed-valence oxo-centered trinuclear iron propionates [FeIII2FeIIO(C2H5CO2)6(py)3[npy; n = 0, 1.5

    International Nuclear Information System (INIS)

    Nakamoto, Tadahiro; Katada, Motomi; Kawata, Satoshi; Kitagawa, Susumu; Sano, Hirotoshi; Konno, Michiko

    1994-01-01

    Mixed-valence trinuclear iron propionates [Fe III 2 Fe II O(C 2 H 5 CO 2 ) 6 (py) 3 [npy, where n = 0, 1.5, were synthesized and the structure of the pyridine-solvated complex was determined by single-crystal X-ray diffraction. Moessbauer spectra of the solvated propionate complex showed a temperature-dependent mixed-valence state related to phase transitions, reaching an almost delocalized valence state at room temperature. On the other hand, the non-solvated propionate showed a remarkable change of the spectral shape related to a phase transition, remaining in a localized valence state at higher temperatures up to room temperature. (orig.)

  12. Fast Breeder Reactor studies

    International Nuclear Information System (INIS)

    Till, C.E.; Chang, Y.I.; Kittel, J.H.; Fauske, H.K.; Lineberry, M.J.; Stevenson, M.G.; Amundson, P.I.; Dance, K.D.

    1980-07-01

    This report is a compilation of Fast Breeder Reactor (FBR) resource documents prepared to provide the technical basis for the US contribution to the International Nuclear Fuel Cycle Evaluation. The eight separate parts deal with the alternative fast breeder reactor fuel cycles in terms of energy demand, resource base, technical potential and current status, safety, proliferation resistance, deployment, and nuclear safeguards. An Annex compares the cost of decommissioning light-water and fast breeder reactors. Separate abstracts are included for each of the parts

  13. Fast track-hoftealloplastik

    DEFF Research Database (Denmark)

    Hansen, Torben Bæk; Gromov, Kirill; Kristensen, Billy B

    2017-01-01

    Fast-track surgery implies a coordinated perioperative approach aimed at reducing surgical stress and facilitating post-operative recovery. The fast-track programme has reduced post-operative length of stay and has led to shorter convalescence with more rapid functional recovery and decreased...... morbidity and mortality in total hip arthroplasty. It should now be a standard total hip arthroplasty patient pathway, but fine tuning of the multiple factors in the fast-track pathway is still needed in patients with special needs or high comorbidity burden....

  14. Fast Breeder Reactor studies

    Energy Technology Data Exchange (ETDEWEB)

    Till, C.E.; Chang, Y.I.; Kittel, J.H.; Fauske, H.K.; Lineberry, M.J.; Stevenson, M.G.; Amundson, P.I.; Dance, K.D.

    1980-07-01

    This report is a compilation of Fast Breeder Reactor (FBR) resource documents prepared to provide the technical basis for the US contribution to the International Nuclear Fuel Cycle Evaluation. The eight separate parts deal with the alternative fast breeder reactor fuel cycles in terms of energy demand, resource base, technical potential and current status, safety, proliferation resistance, deployment, and nuclear safeguards. An Annex compares the cost of decommissioning light-water and fast breeder reactors. Separate abstracts are included for each of the parts.

  15. [Effects on cervical spondylosis of vertebral artery type and the concentrations of plasma NPY and UII in the patients treated with the modified acupuncture at unilateral/bilateral Renying (ST 9)].

    Science.gov (United States)

    Wang, Yanfu; Ma, Chaoyang; Li, Lingxiao; Zhang, Ting; Gui, Xinghua; Chen, Hao

    2018-05-12

    To observe the differences in the clinical therapeutic effects on cervical spondylosis of vertebral artery type (CSA) between the modified acupuncture and the routine acupuncture at unilateral/bilateral Renying (ST 9) as well as the impacts on the concentrations of plasma neuropeptide Y (NPY) and urotensinⅡ(UⅡ) in the patients. A total of 160 patients were divided into a modified bilateral acupuncture group, a modified unilateral acupuncture group, a routine bilateral acupuncture group and a routine unilateral acupuncture group, 40 cases in each one according to the random number table. In the modified bilateral acupuncture group, the modified acupuncture was applied bilaterally to Renying (ST 9). In the modified unilateral acupuncture group, the modified acupuncture was applied unilaterally to Renying (ST 9). In the routine bilateral acupuncture group, the routine acupuncture was applied bilaterally to Renying (ST 9). In the routine unilateral acupuncture group, the routine acupuncture was applied unilaterally to Renying (ST 9). The treatment was given once every day, continuously for 6 days as one course. Two courses of treatment were required at the interval of 1 day. In each group, before and after treatment, we observed the peak systolic blood flow velocity (Vs) of the vertebral artery (VA) and the basilar artery (BA), cervical vertigo symptoms and functional assessment scales (ESCV) and the concentration of plasma NPY and UⅡ. The clinical therapeutic effects were compared among the groups. After treatment, the clinical therapeutic effect in the modified bilateral acupuncture group was 90.0% (36/40), which was better than 80.0% (32/40) in the modified unilateral acupuncture group, 77.5% (35/40) in the routine bilateral acupuncture group and 65.0% (26/40) in the routine unilateral acupuncture group (all P ST 9) effectively regulates the blood supply of the vertebral basilar artery and improves the cerebral circulation. The effects are superior to those of

  16. Intermittent fasting induces hypothalamic modifications resulting in low feeding efficiency, low body mass and overeating.

    Science.gov (United States)

    Chausse, Bruno; Solon, Carina; Caldeira da Silva, Camille C; Masselli Dos Reis, Ivan G; Manchado-Gobatto, Fúlvia B; Gobatto, Claudio A; Velloso, Licio A; Kowaltowski, Alicia J

    2014-07-01

    Intermittent fasting (IF) is an often-used intervention to decrease body mass. In male Sprague-Dawley rats, 24 hour cycles of IF result in light caloric restriction, reduced body mass gain, and significant decreases in the efficiency of energy conversion. Here, we study the metabolic effects of IF in order to uncover mechanisms involved in this lower energy conversion efficiency. After 3 weeks, IF animals displayed overeating during fed periods and lower body mass, accompanied by alterations in energy-related tissue mass. The lower efficiency of energy use was not due to uncoupling of muscle mitochondria. Enhanced lipid oxidation was observed during fasting days, whereas fed days were accompanied by higher metabolic rates. Furthermore, an increased expression of orexigenic neurotransmitters AGRP and NPY in the hypothalamus of IF animals was found, even on feeding days, which could explain the overeating pattern. Together, these effects provide a mechanistic explanation for the lower efficiency of energy conversion observed. Overall, we find that IF promotes changes in hypothalamic function that explain differences in body mass and caloric intake.

  17. FastStats: Measles

    Science.gov (United States)

    ... Women’s Health State and Territorial Data Reproductive Health Contraceptive Use Infertility Reproductive Health Notice Regarding FastStats Mobile ... measles, mumps, rubella: 91.9% (2015) Percent of adolescents aged 13-17 years vaccinated against measles, mumps, ...

  18. Fast neutrons dosimetry

    International Nuclear Information System (INIS)

    Rzyski, B.M.

    1977-01-01

    A proton recoil technique has been developed for inducing thermoluminescence with incident fast neutrons. CaF 2 was used as the TL phosphor, and cane sugar and polyethylene were used as proton radiators. The phosphor and the hydrogeneous material powders were well mixed, encapsulated in glass tubes and exposed to Am-Be sources, resulting in recoils from incident fast neutrons of energy between 0,25 and 11,25 MeV. The intrinsic response of pure CaF 2 to fast neutrons without a hydrogeneous radiator was checked by using LiF (TLD-700). Glow curves were recorded from room temperature up to 350 0 C after different doses of neutrons and gamma rays of 60 Co. First collision dose due to fast neutrons in tissue like materials such as cane sugar and polyethylene was also calculated [pt

  19. Dounreay fast reactor

    International Nuclear Information System (INIS)

    Maclennan, R.; Eggar, T.; Skeet, T.

    1992-01-01

    The short debate which followed a private notice question asking for a statement on Government policy on the future of the European fast breeder nuclear research programme is reported verbatim. In response to the question, the Minister for Energy said that the Government had decided in 1988 that the Dounreay prototype fast reactor would close in 1994. That decision had been confirmed. Funding of fast breeder research and development beyond 1993 is not a priority as commercialization is not expected until well into the next century. Dounreay will be supported financially until 1994 and then for its subsequent decommissioning and reprocessing of spent fuel. The debate raised issues such as Britain losing its lead in fast breeder research, loss of jobs and the Government's nuclear policy in general. However, the Government's position was that the research had reached a stage where it could be left and returned to in the future. (UK)

  20. CMS Fast Facts

    Data.gov (United States)

    U.S. Department of Health & Human Services — CMS has developed a new quick reference statistical summary on annual CMS program and financial data. CMS Fast Facts includes summary information on total program...

  1. Brug af faste vendinger

    DEFF Research Database (Denmark)

    Bergenholtz, Henning; Bjærge, Esben

    Ordbogen indelholder tekstproduktionsangivelser til ca. 17.000 idiomer, ordsprog, bevingede ord og andre faste vendinger. Det drejer sig bl.a. om angivelser til betydningen, grammatik, kollokationer, eksempler, synonymer og antonymer....

  2. Fasting and Urinary Stones

    Directory of Open Access Journals (Sweden)

    Ali Shamsa

    2013-11-01

    Full Text Available Introduction: Fasting is considered as one of the most important practices of Islam, and according to Prophet Mohammad, fasting is obligatory upon Muslims. The aim of this study is to evaluate the effects of fasting on urinary stones. Materials and Methods: Very few studies have been carried out on urinary stones and the effect of Ramadan fasting. The sources of the present study are Medline and articles presented by local and Muslim researchers. Meanwhile, since we are acquainted with three well-known researchers in the field of urology, we contacted them via email and asked for their professional opinions. Results: The results of studies about the relationship of urinary stones and their incidence in Ramadan are not alike, and are even sometimes contradictory. Some believe that increased incidence of urinary stones in Ramadan is related not to fasting, but to the rise of weather temperature in hot months, and an increase in humidity. Conclusion: Numerous biological and behavioral changes occur in people who fast in Ramadan and some researchers believe that urinary stone increases during this month.

  3. Fast breeder reactors

    International Nuclear Information System (INIS)

    Waltar, A.E.; Reynolds, A.B.

    1981-01-01

    This book describes the major design features of fast breeder reactors and the methods used for their design and analysis. The foremost objective of this book is to fulfill the need for a textbook on Fast Breeder Reactor (FBR) technology at the graduate level or the advanced undergraduate level. It is assumed that the reader has an introductory understanding of reactor theory, heat transfer, and fluid mechanics. The book is expected to be used most widely for a one-semester general course on fast breeder reactors, with the extent of material covered to vary according to the interest of the instructor. The book could also be used effectively for a two-quarter or a two-semester course. In addition, the book could serve as a text for a course on fast reactor safety since many topics other than those appearing in the safety chapters relate to FBR safety. Methodology in fast reactor design and analysis, together with physical descriptions of systems, is emphasized in this text more than numerical results. Analytical and design results continue to change with the ongoing evolution of FBR design whereas many design methods have remained fundamentally unchanged for a considerable time

  4. Fast reactor programme

    International Nuclear Information System (INIS)

    Plakman, J.C.

    1982-01-01

    This progress report summarizes the fast reactor research carried out by ECN during the period covering the year 1980. This research is mainly concerned with the cores of sodium-cooled breeders, in particular the SNR-300, and its related safety aspects. It comprises six items: A programme to determine relevant nuclear data of fission- and corrosion-products; A fuel performance programme comprising in-pile cladding failure experiments and a study of the consequences of loss-of-cooling and overpower; Basic research on fuel; Investigation of the changes in the mechanical properties of austenitic stainless steel DIN 1.4948 due to fast neutron doses, this material has been used in the manufacture of the reactor vessel and its internal components; Study of aerosols which could be formed at the time of a fast reactor accident and their progressive behaviour on leaking through cracks in the concrete containment; Studies on heat transfer in a sodium-cooled fast reactor core. As fast breeders operate at high power densities, an accurate knowledge of the heat transfer phenomena under single-phase and two-phase conditions is sought. (Auth.)

  5. Intermittent fasting dietary restriction regimen negatively influences reproduction in young rats: a study of hypothalamo-hypophysial-gonadal axis.

    Directory of Open Access Journals (Sweden)

    Sushil Kumar

    Full Text Available Nutritional infertility is very common in societies where women fail to eat enough to match their energy expenditure and such females often present as clinical cases of anorexia nervosa. The cellular and molecular mechanisms that link energy balance and central regulation of reproduction are still not well understood. Peripheral hormones such as estradiol, testosterone and leptin, as well as neuropeptides like kisspeptin and neuropeptides Y (NPY play a potential role in regulation of reproduction and energy balance with their primary target converging on the hypothalamic median eminence-arcuate region. The present study was aimed to explore the effects of negative energy state resulting from intermittent fasting dietary restriction (IF-DR regimen on complete hypothalamo-hypophysial-gonadal axis in Wistar strain young female and male rats. Significant changes in body weight, blood glucose, estrous cyclicity and serum estradiol, testosterone and LH level indicated the negative role of IF-DR regimen on reproduction in these young animals. Further, it was elucidated whether serum level of metabolic hormone, leptin plays a mechanistic role in suppressing hypothalamo-hypophysial-gonadal (HPG axis via energy regulators, kisspeptin and NPY in rats on IF-DR regimen. We also studied the effect of IF-DR regimen on structural remodeling of GnRH axon terminals in median eminence region of hypothalamus along with the glial cell marker, GFAP and neuronal plasticity marker, PSA-NCAM using immunostaining, Western blotting and RT-PCR. Together these data suggest that IF-DR regimen negatively influences reproduction in young animals due to its adverse effects on complete hypothalamus-hypophysial-gonadal axis and may explain underlying mechanism(s to understand the clinical basis of nutritional infertility.

  6. Intermittent fasting dietary restriction regimen negatively influences reproduction in young rats: a study of hypothalamo-hypophysial-gonadal axis.

    Science.gov (United States)

    Kumar, Sushil; Kaur, Gurcharan

    2013-01-01

    Nutritional infertility is very common in societies where women fail to eat enough to match their energy expenditure and such females often present as clinical cases of anorexia nervosa. The cellular and molecular mechanisms that link energy balance and central regulation of reproduction are still not well understood. Peripheral hormones such as estradiol, testosterone and leptin, as well as neuropeptides like kisspeptin and neuropeptides Y (NPY) play a potential role in regulation of reproduction and energy balance with their primary target converging on the hypothalamic median eminence-arcuate region. The present study was aimed to explore the effects of negative energy state resulting from intermittent fasting dietary restriction (IF-DR) regimen on complete hypothalamo-hypophysial-gonadal axis in Wistar strain young female and male rats. Significant changes in body weight, blood glucose, estrous cyclicity and serum estradiol, testosterone and LH level indicated the negative role of IF-DR regimen on reproduction in these young animals. Further, it was elucidated whether serum level of metabolic hormone, leptin plays a mechanistic role in suppressing hypothalamo-hypophysial-gonadal (HPG) axis via energy regulators, kisspeptin and NPY in rats on IF-DR regimen. We also studied the effect of IF-DR regimen on structural remodeling of GnRH axon terminals in median eminence region of hypothalamus along with the glial cell marker, GFAP and neuronal plasticity marker, PSA-NCAM using immunostaining, Western blotting and RT-PCR. Together these data suggest that IF-DR regimen negatively influences reproduction in young animals due to its adverse effects on complete hypothalamus-hypophysial-gonadal axis and may explain underlying mechanism(s) to understand the clinical basis of nutritional infertility.

  7. The fast breeder reactor

    International Nuclear Information System (INIS)

    Patterson, W.

    1990-01-01

    The author criticises the United Kingdom Atomic Energy Authority's fast breeder reactor programme in his evidence to the House of Commons Select Committee on Energy in January 1990. He argues for power generation by renewable means and greater efficiency in the use rather than in the generation of electricity. He refutes the arguments for nuclear power on the basis of reduced global warming as he claims support technology produces significant amounts of carbon dioxide in any case. Serious doubts are raised about the costs of a fast breeder reactor programme compared to, say, generation by pressurised water reactors. The idea of a uranium scarcity in several decades is also refuted. The reliability of fast breeder reactor technology is called into question. He argues against reprocessing plutonium for economic, health and safety reasons. (UK)

  8. The fast code

    Energy Technology Data Exchange (ETDEWEB)

    Freeman, L.N.; Wilson, R.E. [Oregon State Univ., Dept. of Mechanical Engineering, Corvallis, OR (United States)

    1996-09-01

    The FAST Code which is capable of determining structural loads on a flexible, teetering, horizontal axis wind turbine is described and comparisons of calculated loads with test data are given at two wind speeds for the ESI-80. The FAST Code models a two-bladed HAWT with degrees of freedom for blade bending, teeter, drive train flexibility, yaw, and windwise and crosswind tower motion. The code allows blade dimensions, stiffnesses, and weights to differ and models tower shadow, wind shear, and turbulence. Additionally, dynamic stall is included as are delta-3 and an underslung rotor. Load comparisons are made with ESI-80 test data in the form of power spectral density, rainflow counting, occurrence histograms, and azimuth averaged bin plots. It is concluded that agreement between the FAST Code and test results is good. (au)

  9. Fast harmonic field mapper

    International Nuclear Information System (INIS)

    Au, R.; Fowler, M.; Hanawa, H.; Riedel, J.; Qua, Z.G.

    1984-01-01

    In early 1983 it was decided to mount coils on arms separated by 120 degrees and buck them out so that the third harmonic dphi/dt component would be cancelled and thus the first and second field harmonics could be very accurately measured. The original intention was to do as others had done, namely, use fast ADC's to read the voltages, and computer process the result to get the Fourier components. However, because of the 100 to 1 dynamic range of the fast ADC's and the likelihood that noise would be a problem, the authors decided to do things differently. Using a fast Fourier transform analyzer was considered, but this instrument is very expensive, so they decided to use a completely electronic analog approach: The authors decided to use active bandpass filters to render the harmonic components

  10. Fast beam radiofrequency spectroscopy

    International Nuclear Information System (INIS)

    Pipkin, F.M.

    1983-01-01

    The combination of a fast atom or ion beam derived from a small accelerator with radiofrequency spectroscopy methods provides a powerful method for measuring the fine structure of atomic and molecular systems. The fast beam makes possible measurements in which two separated oscillatory fields are used to obtain resonance lines whose widths are less than the natural line width due to the lifetimes of the states. The separated oscillatory field lines have, in addition, a number of features which make possible measurements with greater precision and less sensitivity to systematic errors. The fast beam also makes accessible multiple photon radiofrequency transitions whose line width is intrinsically narrower than that of the single photon transitions and which offer great potential for high precision measurements. This report focuses on the techniques and their promise. Recent measurements of the fine structure of H and He + are used as illustrations

  11. The fast breeder reactor

    International Nuclear Information System (INIS)

    Keck, O.

    1984-01-01

    Nowadays the fast-breeder reactor is a negative symbol of advanced technology which is getting out of control and, due to its complexity, is incomprehensible for politicians and therefore by-passes the established order. The author lists the most important decisions over state aid to the fast-breeder-reactors up until the mid-seventies and uses documents from the appropriate advisory bodies as reference. He was also aided by interviews with those directly involved with the project. The empirical facts forces us to discard our traditional view of the relationship between state and industry with regard to advanced technology. The author explains that it is impossible to find any economic value in the fast-breeder reactor. The insight gained through this project allows him to draw conclusions which apply to all aspects of state aid to advanced technology. (orig.) [de

  12. Adopting preoperative fasting guidelines.

    Science.gov (United States)

    Anderson, Megan; Comrie, Rhonda

    2009-07-01

    In 1999, the American Society of Anesthesiologists adopted preoperative fasting guidelines to enhance the quality and efficiency of patient care. Guidelines suggest that healthy, non-pregnant patients should fast six hours from solids and two hours from liquids. Although these guidelines are in place, studies suggest that providers are still using the blanket statement "NPO after midnight" without regard to patient characteristics, the procedure, or the time of the procedure. Using theory to help change provider's beliefs may help make change more successful. Rogers' Theory of Diffusion of Innovations can assist in changing long-time practice by laying the groundwork for an analysis of the benefits and disadvantages of proposed changes, such as changes to fasting orders, while helping initiate local protocols instead of additional national guidelines.

  13. Proton Fast Ignition

    International Nuclear Information System (INIS)

    Key, M H; Freeman, R R; Hatchett, S P; MacKinnon, A J; Patel, P K; Snavely, R A; Stephens, R B

    2006-04-01

    Fast ignition (FI) by a laser generated ballistically focused proton beam is a more recently proposed alternative to the original concept of FI by a laser generated beam of relativistic electrons. It has potential advantages in less complex energy transport into dense plasma. Recent successful target heating experiments motivate further investigation of the feasibility of proton fast ignition. The concept, the physics and characteristics of the proton beams, the recent experimental work on focusing of the beams and heating of solid targets and the overall prospects for proton FI are discussed

  14. Fast breeder project (PSB)

    International Nuclear Information System (INIS)

    1976-07-01

    Activities performed during the 1st quarter of 1976 at or on behalf of the Gesellschaft fuer Kernforschung mbH, Karlsruhe, within the framework of the Fast Breeder Project are given a survey. The following project subdivisions are dealt with: Fuel rod development; materials testing and developments; corrosion studies and coolant analyses; physical experiments; reactor theory; safety of fast breeders; instrumentation and signal processing for core monitoring; effects on the environment; sodium technology tests; thermodynamic and fluid flow tests in gas. (HR) [de

  15. Magnetically Assisted Fast Ignition

    OpenAIRE

    Wang, W.-M.; Gibbon, P.; Sheng, Z.-M.; Li, Y.-T.

    2015-01-01

    Fast ignition (FI) is investigated via integrated particle-in-cell simulation including both generation andtransport of fast electrons, where petawatt ignition lasers of 2 ps and compressed targets of a peak density of300 g cm−3 and areal density of 0.49 g cm−2 at the core are taken. When a 20 MG static magnetic field isimposed across a conventional cone-free target, the energy coupling from the laser to the core is enhancedby sevenfold and reaches 14%. This value even exceeds that obtained u...

  16. Fast neutron dosimetry

    International Nuclear Information System (INIS)

    DeLuca, P.M. Jr.; Pearson, D.W.

    1993-01-01

    Research concentrated on three major areas during the last twelve months: (1) investigations of energy fluence and absorbed dose measurements using crystalline and hot pressed TLD materials exposes to ultrasoft beams of photons, (2) fast neutron kerma factor measurements for several important elements as well as NE-213 scintillation material response function determinations at the intense ''white'' source available at the WNR facility at LAMPF, and (3) kerma factor ratio determinations for carbon and oxygen to A-150 tissue equivalent plastic at the clinical fast neutron radiation facility at Harper Hospital, Detroit, MI. Progress summary reports of these efforts are given in this report

  17. Moms og fast ejendom

    DEFF Research Database (Denmark)

    Edlund, Hans Henrik

    1999-01-01

    I artiklen gives et overblik over, hvorledes fast ejendom behandles momsmæssigt. Derfor findes en kort skitsering af reglerne for moms på byggearbejder, afgrænsningen mellem momspligtig og momsfri udlejning, muligheden for frivillig registrering af udlejning samt opgørelse af reguleringsforpligte......I artiklen gives et overblik over, hvorledes fast ejendom behandles momsmæssigt. Derfor findes en kort skitsering af reglerne for moms på byggearbejder, afgrænsningen mellem momspligtig og momsfri udlejning, muligheden for frivillig registrering af udlejning samt opgørelse af...

  18. Fast ejendom II

    DEFF Research Database (Denmark)

    Munk-Hansen, Carsten

    Fremstillingen påviser, at lov om forbrugerbeskyttelse ved erhvervelse af fast ejendom mv. lider af en række svagheder og at ankenævnspraksis bevæger sig væk fra retspraksis på en række områder.......Fremstillingen påviser, at lov om forbrugerbeskyttelse ved erhvervelse af fast ejendom mv. lider af en række svagheder og at ankenævnspraksis bevæger sig væk fra retspraksis på en række områder....

  19. [Preoperative fasting. An update].

    Science.gov (United States)

    Spies, C D; Breuer, J P; Gust, R; Wichmann, M; Adolph, M; Senkal, M; Kampa, U; Weissauer, W; Schleppers, A; Soreide, E; Martin, E; Kaisers, U; Falke, K J; Haas, N; Kox, W J

    2003-11-01

    In Germany the predominant standard of preoperative care for elective surgery is fasting after midnight, with the aim of reducing the risk of pulmonary aspiration. However, for the past several years the scientific evidence supporting such a practice has been challenged. Experimental and clinical studies prove a reliable gastric emptying within 2 h suggesting that, particularly for limited intake of clear fluids up to 2 h preoperatively, there would be no increased risk for the patient. In addition, the general incidence of pulmonary aspiration during general anaesthesia (before induction, during surgery and during recovery) is extremely low, has a good prognosis and is more a consequence of insufficient airway protection and/or inadequate anaesthetic depth rather than due to the patient's fasting state. Therefore, primarily to decrease perioperative discomfort for patients, several national anaesthesia societies have changed their guidelines for preoperative fasting. They recommend a more liberal policy regarding per os intake of both liquid and solid food, with consideration of certain conditions and contraindications. The following article reviews the literature and gives an overview of the scientific background on which the national guidelines are based. The intention of this review is to propose recommendations for preoperative fasting regarding clear fluids for Germany as well.

  20. Integral Fast Reactor concept

    International Nuclear Information System (INIS)

    Till, C.E.; Chang, Y.I.

    1986-01-01

    The Integral Fast Reactor (IFR) is an innovative LMR concept, being developed at Argonne National Laboratory, that fully exploits the inherent properties of liquid metal cooling and metallic fuel to achieve breakthroughs in economics and inherent safety. This paper describes key features and potential advantages of the IFR concept, technology development status, fuel cycle economics potential, and future development path

  1. FastStats: Immunization

    Science.gov (United States)

    ... Women’s Health State and Territorial Data Reproductive Health Contraceptive Use Infertility Reproductive Health Notice Regarding FastStats Mobile ... 69 [PDF – 9.8 MB] Vaccination coverage among adolescents 13-17 years of age Health, United States, ...

  2. Integral Fast Reactor concept

    Energy Technology Data Exchange (ETDEWEB)

    Till, C.E.; Chang, Y.I.

    1986-01-01

    The Integral Fast Reactor (IFR) is an innovative LMR concept, being developed at Argonne National Laboratory, that fully exploits the inherent properties of liquid metal cooling and metallic fuel to achieve breakthroughs in economics and inherent safety. This paper describes key features and potential advantages of the IFR concept, technology development status, fuel cycle economics potential, and future development path.

  3. Parallel Fast Legendre Transform

    NARCIS (Netherlands)

    Alves de Inda, M.; Bisseling, R.H.; Maslen, D.K.

    1998-01-01

    We discuss a parallel implementation of a fast algorithm for the discrete polynomial Legendre transform We give an introduction to the DriscollHealy algorithm using polynomial arithmetic and present experimental results on the eciency and accuracy of our implementation The algorithms were

  4. The Integral Fast Reactor

    International Nuclear Information System (INIS)

    Till, C.E.; Chang, Y.I.; Lineberry, M.J.

    1990-01-01

    Argonne National Laboratory, since 1984, has been developing the Integral Fast Reactor (IFR). This paper will describe the way in which this new reactor concept came about; the technical, public acceptance, and environmental issues that are addressed by the IFR; the technical progress that has been made; and our expectations for this program in the near term. 5 refs., 3 figs

  5. Viden om faste vendinger

    DEFF Research Database (Denmark)

    Bergenholtz, Henning; Bjærge, Esben

    2012-01-01

    Ordbogen indeholder ca. 17.000 idiomer, ordsprog, bevingede ord og andre faste vendinger, som der oplyses mest muligt om. Hertil hører oplysninger om betydningen, grammatik, kollokationer, synonymer, stil, ordforbindelsestype, etymologiske angivelser og andre baggrundsoplysninger, links til...

  6. Integral Fast Reactor Program

    International Nuclear Information System (INIS)

    Chang, Y.I.; Walters, L.C.; Laidler, J.J.; Pedersen, D.R.; Wade, D.C.; Lineberry, M.J.

    1993-06-01

    This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1992. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R ampersand D

  7. FAST goes underground

    International Nuclear Information System (INIS)

    Fridlund, P.S.

    1985-01-01

    The FAST-M Cost Estimating Model is a parametric model designed to determine the costs associated with mining and subterranean operations. It is part of the FAST (Freiman Analysis of Systems Techniques) series of parametric models developed by Freiman Parametric Systems, Inc. The rising cost of fossil fuels has created a need for a method which could be used to determine and control costs in mining and subterranean operations. FAST-M fills this need and also provides scheduling information. The model works equally well for a variety of situations including underground vaults for hazardous waste storage, highway tunnels, and mass transit tunnels. In addition, costs for above ground structures and equipment can be calculated. The input for the model may be on a macro or a micro level. This allows the model to be used at various stages in a project. On the macro level, only general conditions and specifications need to be known. On the micro level, the smallest details may be included. As with other FAST models, reference cases are used to more accurately predict costs and scheduling. This paper will address how the model can be used for a variety of subterranean purposes

  8. Fast Air Temperature Sensors

    DEFF Research Database (Denmark)

    Hendricks, Elbert

    1998-01-01

    The note documents briefly work done on a newly developed sensor for making fast temperature measurements on the air flow in the intake ports of an SI engine and in the EGR input line. The work reviewed has been carried out in close cooperation with Civ. Ing. Michael Føns, the author (IAU...

  9. Project fast breeder (PSB)

    International Nuclear Information System (INIS)

    1978-01-01

    The annual report of the fast breeder project (PSB) contains contributions of the participating institutes on the four subjects: 1) Development of oxidic fuel rods and materials for the SNR line, 2) Physics and safety investigations for the SNR line, 3) Carbidic fuel elements, and 4) Back-up solution with gaseous coolant. (HK) [de

  10. Fast ejendom, I

    DEFF Research Database (Denmark)

    Munk-Hansen, Carsten

    , værdiforringende forhold, der ligger uden for ejendommen og andre særlige tilfælde. Bogen uddyber andre emner omtalt i 1. udgave, eksempelvis erhvervelsesbetingelser, købsoptioner, ansvarsfraskrivelse, licitationssalg mv. Bogen er det første af tre planlagte bind om fast ejendom: I Overdragelsen, II Bolighandlen...

  11. Handel med fast ejendom

    DEFF Research Database (Denmark)

    Edlund, Hans Henrik

    Bogen tilstræber at give et overblik over nogle af de vigtigste generelle problemområder på markedet for ejendomshandel, der jo bliver mere og mere kompliceret. Værket er opdelt i følgende hovedafsnit: Ejendomsbegrebet. Indgåelse af aftale om salg af fast ejendom. Begrænsninger i adgangen til...

  12. Fast Harmonic Chirp Summation

    DEFF Research Database (Denmark)

    Nielsen, Jesper Kjær; Jensen, Tobias Lindstrøm; Jensen, Jesper Rindom

    2017-01-01

    -robust to noise, or very computationally inten- sive. In this paper, we propose a fast algorithm for the harmonic chirp summation method which has been demonstrated in the liter- ature to be accurate and robust to noise. The proposed algorithm is orders of magnitudes faster than previous algorithms which is also...

  13. Nanolensed Fast Radio Bursts

    Science.gov (United States)

    Eichler, David

    2017-12-01

    It is suggested that fast radio bursts can probe gravitational lensing by clumpy dark matter objects that range in mass from 10-3 M ⊙-102 M ⊙. They may provide a more sensitive probe than observations of lensings of objects in the Magellanic Clouds, and could find or rule out clumpy dark matter with an extended mass spectrum.

  14. ATLAS fast physics monitoring

    Indian Academy of Sciences (India)

    The ATLAS Collaboration has set up a framework to automatically process the rapidly growing dataset and produce performance and physics plots for the most interesting analyses. The system is designed to give fast feedback. The histograms are produced within hours of data reconstruction (2–3 days after data taking).

  15. Calorie count - fast food

    Science.gov (United States)

    ... GO About MedlinePlus Site Map FAQs Customer Support Health Topics Drugs & Supplements Videos & Tools Español You Are Here: Home → Medical Encyclopedia → Calorie count - fast food URL of this page: //medlineplus.gov/ency/patientinstructions/ ...

  16. Fast breeder reactor research

    International Nuclear Information System (INIS)

    1975-01-01

    Full text: The meeting was attended by 15 participants from seven countries and two international organizations. The Eighth Annual Meeting of the International Working Group on Fast Reactors (IWGFR) was attended by representatives from France, Fed. Rep. Germany, Italy, Japan, United Kingdom, Union of Soviet Socialist Republics and the United States of America - countries that have made significant progress in developing the technology and physics of sodium cooled fast reactors and have extensive national programmes in this field - as well as by representatives of the Commission of the European Communities and the IAEA. The design of fast-reactor power plants is a more difficult task than developing facilities with thermal reactors. Different reactor kinetics and dynamics, a hard neutron spectrum, larger integral doses of fuel and structural material irradiation, higher core temperatures, the use of an essentially novel coolant, and, as a result of all these factors, the additional reliability and safety requirements that are imposed on the planning and operation of sodium cooled fast reactors - all these factors pose problems that can be solved comprehensively only by countries with a high level of scientific and technical development. The exchange of experience between these countries and their combined efforts in solving the fundamental problems that arise in planning, constructing and operating fast reactors are promoting technical progress and reducing the relative expenditure required for various studies on developing and introducing commercial fast reactors. For this reason, the meeting concentrated on reviewing and discussing national fast reactor programmes. The situation with regard to planning, constructing and operating fast experimental and demonstration reactors in the countries concerned, the experience accumulated in operating them, the difficulties arising during operation and ways of over-coming them, the search for optimal designs for the power

  17. Comparative Evaluation of Pain, Stress, Neuropeptide Y, ACTH, and Cortisol Levels Between a Conventional Postoperative Care Protocol and a Fast-Track Recovery Program in Patients Undergoing Major Abdominal Surgery.

    Science.gov (United States)

    Kapritsou, Maria; Papathanassoglou, Elizabeth D; Bozas, Evangelos; Korkolis, Dimitrios P; Konstantinou, Evangelos A; Kaklamanos, Ioannis; Giannakopoulou, Margarita

    2017-03-01

    Fast-track (FT) postoperative protocol in oncological patients after major abdominal surgery reduces complications and length of postoperative stay compared to the conventional (CON) protocol. However, stress and pain responses have not been compared between the two protocols. To compare stress, pain, and related neuropeptidic responses (adrenocorticotropic hormone [ACTH], cortisol, and neuropeptide Y [NPY]) between FT and CON protocols. A clinical trial with repeated measurements was conducted (May 2012 to May 2014) with a sample of 63 hepatectomized or pancreatectomized patients randomized into two groups: FT ( n = 29) or CON ( n = 34). Demographic and clinical data were collected, and pain (Visual Analog Scale [VAS] and Behavioral Pain Scale [BPS]) and stress responses (3 self-report questions) assessed. NPY, ACTH, and cortisol plasma levels were measured at T1 = day of admission, T2 = day of surgery, and T3 = prior to discharge. ACTH T1 and ACTH T2 levels were positively correlated with self-reported stress levels (ρ = .43 and ρ = .45, respectively, p .05). Neuropeptidic levels were higher in the FT group. Future research should evaluate this association further, as these biomarkers might serve as objective indicators of postoperative pain and stress.

  18. Preoperative fasting times: Prescribed and actual fasting times at ...

    African Journals Online (AJOL)

    The current international guidelines for preoperative fasting for elective surgery are 6 ... to determine whether this policy was being followed and patients were being starved ..... recommended fasting time, so that autonomous patients take care.

  19. Inorganic component of saliva during fasting and after fast break

    OpenAIRE

    Samad, Rasmidar

    2016-01-01

    Oral health is closely related to salivary components. Saliva consists of water, inorganic and organic materials. Fasting changes one???s meal and drinking time that in turn can affect the environment in oral cavity, including inorganic componenet of saliva. The purpose of this study is to determine the inorganic component of saliva during fasting and after fast break.

  20. Fast Flux Test Facility

    International Nuclear Information System (INIS)

    Munn, W.I.

    1981-01-01

    The Fast Flux Test Facility (FFTF), located on the Hanford site a few miles north of Richland, Washington, is a major link in the chain of development required to sustain and advance Liquid Metal Fast Breeder Reactor (LMFBR) technology in the United States. This 400 MWt sodium cooled reactor is a three loop design, is operated by Westinghouse Hanford Company for the US Department of Energy, and is the largest research reactor of its kind in the world. The purpose of the facility is three-fold: (1) to provide a test bed for components, materials, and breeder reactor fuels which can significantly extend resource reserves; (2) to produce a complete body of base data for the use of liquid sodium in heat transfer systens; and (3) to demonstrate inherent safety characteristics of LMFBR designs

  1. Fast radiographic systems

    International Nuclear Information System (INIS)

    Domanus, J.C.

    1984-08-01

    Industrial radiography can be performed with shorter exposure times, when instead of X-ray film with lead intensifying screens the radiographic paper with fluorescent screen is used. With paper radiography one can obtain lower material, equipment, and labor costs, shorter exposure and processing times, and easier radiation protection. The speed of the radiographic inspection can also be increased by the use of fluorometallic intensifying screens together with a special brand of X-ray film. Before accepting either of the two fast radiographic systems one must be sure that they can produce radiographs of adequate image quality. Therefore an investigation was performed on that subject using ISO wire IQI's and ASTM penetrameters. The radiographic image quality was tested for aluminium and steel up to 30 mm thick using various brands of radiographic paper and X-ray film with fluorometallic screens and comparing them with fast X-ray films with lead screens. Both systems give satisfactory results. (author)

  2. Fast geometric algorithms

    International Nuclear Information System (INIS)

    Noga, M.T.

    1984-01-01

    This thesis addresses a number of important problems that fall within the framework of the new discipline of Computational Geometry. The list of topics covered includes sorting and selection, convex hull algorithms, the L 1 hull, determination of the minimum encasing rectangle of a set of points, the Euclidean and L 1 diameter of a set of points, the metric traveling salesman problem, and finding the superrange of star-shaped and monotype polygons. The main theme of all the work was to develop a set of very fast state-of-the-art algorithms that supersede any rivals in terms of speed and ease of implementation. In some cases existing algorithms were refined; for others new techniques were developed that add to the present database of fast adaptive geometric algorithms. What emerges is a collection of techniques that is successful at merging modern tools developed in analysis of algorithms with those of classical geometry

  3. The ELETTRA fast magnets

    International Nuclear Information System (INIS)

    Tommasini, D.

    1992-01-01

    The design of the fast magnets to be used to inject the electron beam into the 2 GeV storage ring Elettra is presented and discussed. Injection makes use of two types of fast magnets: the septa and the kickers. There are two identical septa magnets of the so called 'eddy current' type, which will be housed in a vacuum tank. The orbit bump is generated by four identical kicker magnets symmetrically placed around the mid-point of a single straight section: they will be in air with an internal vacuum chamber. Extensive electric and magnetic tests have been performed on prototypes, and the relevant results are presented and discussed. (author) 6 refs.; 6 figs.; 2 tabs

  4. Fast timing discriminator

    International Nuclear Information System (INIS)

    Lo, C.C.

    1977-01-01

    The processing of pulses with very fast risetimes for timing purposes involves many problems because of the large equivalent bandwidths involved. For pulses with risetimes in the 150 ps range (and full widths at half maximum (FWHM) of 400 ps) bandwidths in excess of 1GHz are required. Furthermore, these very narrow pulses with current amplitudes as small as 1 mA carry very small charges ( -12 coulomb), therefore, requiring very sensitive trigger circuits. The difficulty increases when timing characteristics in the picosecond range are sought especially when a wide input signal amplitude range causes a time-walk problem. The fast timing discriminator described has a time-walk of approximately +-75 ps over the input signal range from 80 mV to 3V. A schematic of the discriminator is included, and operation and performance are discussed

  5. Fast reactor database

    International Nuclear Information System (INIS)

    1996-02-01

    This publication contains detailed data on liquid metal cooled fast reactors (LMFRs), specifically plant parameters and design details. Each LMFR power plant is characterized by about 400 parameters, by design data and by relevant materials. The report provides general and detailed design characteristics including structural materials, data on experimental, demonstration, prototype and commercial size LMFRs. The focus is on practical issues that are useful to engineers, scientists, managers and university students and professors. The report includes updated information contained in IAEA previous publications on LMFR plant parameters: IWGRF/51 (1985) and IWGFR/80 (1991) and reflects experience gained from two consultants meetings held in Vienna (1993,1994). This compilation of data was produced by members of the IAEA International Working Group on Fast Reactors (IWGFR)

  6. Fast electrochemical actuator

    International Nuclear Information System (INIS)

    Uvarov, I V; Postnikov, A V; Svetovoy, V B

    2016-01-01

    Lack of fast and strong microactuators is a well-recognized problem in MEMS community. Electrochemical actuators can develop high pressure but they are notoriously slow. Water electrolysis produced by short voltage pulses of alternating polarity can overcome the problem of slow gas termination. Here we demonstrate an actuation regime, for which the gas pressure is relaxed just for 10 μs or so. The actuator consists of a microchamber filled with the electrolyte and covered with a flexible membrane. The membrane bends outward when the pressure in the chamber increases. Fast termination of gas and high pressure developed in the chamber are related to a high density of nanobubbles in the chamber. The physical processes happening in the chamber are discussed so as problems that have to be resolved for practical applications of this actuation regime. The actuator can be used as a driving engine for microfluidics. (paper)

  7. PHENIX Fast TOF

    Energy Technology Data Exchange (ETDEWEB)

    Soha, Aria [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Chiu, Mickey [Brookhaven National Lab. (BNL), Upton, NY (United States); Mannel, Eric [Brookhaven National Lab. (BNL), Upton, NY (United States); Stoll, Sean [Brookhaven National Lab. (BNL), Upton, NY (United States); Lynch, Don [Brookhaven National Lab. (BNL), Upton, NY (United States); Boose, Steve [Brookhaven National Lab. (BNL), Upton, NY (United States); Northacker, Dave [Brookhaven National Lab. (BNL), Upton, NY (United States); Alfred, Marcus [Howard Univ., Washington, DC (United States); Lindesay, James [Howard Univ., Washington, DC (United States); Chujo, Tatsuya [Univ. of Tsukuba (Japan); Inaba, Motoi [Univ. of Tsukuba (Japan); Nonaka, Toshihiro [Univ. of Tsukuba (Japan); Sato, Wataru [Univ. of Tsukuba (Japan); Sakatani, Ikumi [Univ. of Tsukuba (Japan); Hirano, Masahiro [Univ. of Tsukuba (Japan); Choi, Ihnjea [Univ. of Illinois, Urbana-Champaign, IL (United States)

    2014-01-15

    This is a technical scope of work (TSW) between the Fermi National Accelerator Laboratory (Fermilab) and the experimenters of PHENIX Fast TOF group who have committed to participate in beam tests to be carried out during the FY2014 Fermilab Test Beam Facility program. The goals for this test beam experiment are to verify the timing performance of the two types of time-of-flight detector prototypes.

  8. Fast diamond photoconductors

    International Nuclear Information System (INIS)

    Pochet, T.

    1993-01-01

    Preliminary results on the response of type Ib and IIa diamond photodetectors to fast laser pulse exposures at 265 and 530 nm are presented. The influence of the applied bias, the laser wavelengths and the light intensity on the detector sensitivity is studied. Also, recent measurements with 1.25 MeV gamma ray pulses are reported. (authors). 13 refs., 7 figs., 1 tab

  9. Integral fast reactor

    International Nuclear Information System (INIS)

    Chang, Y.I.

    1989-01-01

    The Integral Fast Reactor (IFR) is an innovative liquid metal reactor concept being developed at Argonne National Laboratory. It seeks to specifically exploit the inherent properties of liquid metal cooling and metallic fuel in a way that leads to substantial improvements in the characteristics of the complete reactor system. This paper describes the key features and potential advantages of the IFR concept, with emphasis on its safety characteristics

  10. Fast antihydrogen beam spectroscopy

    International Nuclear Information System (INIS)

    Neumann, R.

    1989-01-01

    The motivation for production and precision spectroscopy of antihydrogen atoms is outlined. An experimental configuration is considered, concerning laser-microwave spectroscopy of a fast hydrogen beam with characteristics similar to those of an antihydrogen beam emanating from an antiproton-positron overlap region in an antiproton storage ring. In particular, a possible experiment for the measurement of the ground state hyperfine structure splitting is described. (orig.)

  11. The Integral Fast Reactor

    International Nuclear Information System (INIS)

    Chang, Y.I.

    1988-01-01

    The Integral Fast Reactor (IFR) is an innovative liquid metal reactor concept being developed at Argonne National Laboratory. It seeks to specifically exploit the inherent properties of liquid metal cooling and metallic fuel in a way that leads to substantial improvements in the characteristics of the complete reactor system. This paper describes the key features and potential advantages of the IFR concept, with emphasis on its safety characteristics. 3 refs., 4 figs., 1 tab

  12. Fasting - the ultimate diet?

    Science.gov (United States)

    Johnstone, A M

    2007-05-01

    Adult humans often undertake acute fasts for cosmetic, religious or medical reasons. For example, an estimated 14% of US adults have reported using fasting as a means to control body weight and this approach has long been advocated as an intermittent treatment for gross refractory obesity. There are unique historical data sets on extreme forms of food restriction that give insight into the consequences of starvation or semi-starvation in previously healthy, but usually non-obese subjects. These include documented medical reports on victims of hunger strike, famine and prisoners of war. Such data provide a detailed account on how the body adapts to prolonged starvation. It has previously been shown that fasting for the biblical period of 40 days and 40 nights is well within the overall physiological capabilities of a healthy adult. However, the specific effects on the human body and mind are less clearly documented, either in the short term (hours) or in the longer term (days). This review asks the following three questions, pertinent to any weight-loss therapy, (i) how effective is the regime in achieving weight loss, (ii) what impact does it have on psychology? and finally, (iii) does it work long-term?

  13. ADT fast losses MD

    CERN Document Server

    Priebe, A; Dehning, B; Redaelli, S; Salvachua Ferrando, BM; Sapinski, M; Solfaroli Camillocci, M; Valuch, D

    2013-01-01

    The fast beam losses in the order of 1 ms are expected to be a potential major luminosity limitation for higher beam energies after the LHC long shutdown (LS1). Therefore a Quench Test is planned in the winter 2013 to estimate the quench limit in this timescale and revise the current models. This experiment was devoted to determination the LHC Transverse Damper (ADT) as a system for fast losses induction. A non-standard operation of the ADT was used to develop the beam oscillation instead of suppressing them. The sign flip method had allowed us to create the fast losses within several LHC turns at 450 GeV during the previous test (26th March 2012). Thus, the ADT could be potentially used for the studies of the UFO ("Unidentied Falling Object") impact on the cold magnets. Verification of the system capability and investigations of the disturbed beam properties were the main objectives of this MD. During the experiment, the pilot bunches of proton beam were excited independently in the horizontal and vertical ...

  14. Fast Light Optical Gyroscopes

    Science.gov (United States)

    Smith, David D.

    2015-01-01

    Next-generation space missions are currently constrained by existing spacecraft navigation systems which are not fully autonomous. These systems suffer from accumulated dead-reckoning errors and must therefore rely on periodic corrections provided by supplementary technologies that depend on line-of-sight signals from Earth, satellites, or other celestial bodies for absolute attitude and position determination, which can be spoofed, incorrectly identified, occluded, obscured, attenuated, or insufficiently available. These dead-reckoning errors originate in the ring laser gyros themselves, which constitute inertial measurement units. Increasing the time for standalone spacecraft navigation therefore requires fundamental improvements in gyroscope technologies. One promising solution to enhance gyro sensitivity is to place an anomalous dispersion or fast light material inside the gyro cavity. The fast light essentially provides a positive feedback to the gyro response, resulting in a larger measured beat frequency for a given rotation rate as shown in figure 1. Game Changing Development has been investing in this idea through the Fast Light Optical Gyros (FLOG) project, a collaborative effort which began in FY 2013 between NASA Marshall Space Flight Center (MSFC), the U.S. Army Aviation and Missile Research, Development, and Engineering Center (AMRDEC), and Northwestern University. MSFC and AMRDEC are working on the development of a passive FLOG (PFLOG), while Northwestern is developing an active FLOG (AFLOG). The project has demonstrated new benchmarks in the state of the art for scale factor sensitivity enhancement. Recent results show cavity scale factor enhancements of approx.100 for passive cavities.

  15. Metabolic Effects of Intermittent Fasting.

    Science.gov (United States)

    Patterson, Ruth E; Sears, Dorothy D

    2017-08-21

    The objective of this review is to provide an overview of intermittent fasting regimens, summarize the evidence on the health benefits of intermittent fasting, and discuss physiological mechanisms by which intermittent fasting might lead to improved health outcomes. A MEDLINE search was performed using PubMed and the terms "intermittent fasting," "fasting," "time-restricted feeding," and "food timing." Modified fasting regimens appear to promote weight loss and may improve metabolic health. Several lines of evidence also support the hypothesis that eating patterns that reduce or eliminate nighttime eating and prolong nightly fasting intervals may result in sustained improvements in human health. Intermittent fasting regimens are hypothesized to influence metabolic regulation via effects on (a) circadian biology, (b) the gut microbiome, and (c) modifiable lifestyle behaviors, such as sleep. If proven to be efficacious, these eating regimens offer promising nonpharmacological approaches to improving health at the population level, with multiple public health benefits.

  16. Neighborhood fast food availability and fast food consumption.

    Science.gov (United States)

    Oexle, Nathalie; Barnes, Timothy L; Blake, Christine E; Bell, Bethany A; Liese, Angela D

    2015-09-01

    Recent nutritional and public health research has focused on how the availability of various types of food in a person's immediate area or neighborhood influences his or her food choices and eating habits. It has been theorized that people living in areas with a wealth of unhealthy fast-food options may show higher levels of fast-food consumption, a factor that often coincides with being overweight or obese. However, measuring food availability in a particular area is difficult to achieve consistently: there may be differences in the strict physical locations of food options as compared to how individuals perceive their personal food availability, and various studies may use either one or both of these measures. The aim of this study was to evaluate the association between weekly fast-food consumption and both a person's perceived availability of fast-food and an objective measure of fast-food presence - Geographic Information Systems (GIS) - within that person's neighborhood. A randomly selected population-based sample of eight counties in South Carolina was used to conduct a cross-sectional telephone survey assessing self-report fast-food consumption and perceived availability of fast food. GIS was used to determine the actual number of fast-food outlets within each participant's neighborhood. Using multinomial logistic regression analyses, we found that neither perceived availability nor GIS-based presence of fast-food was significantly associated with weekly fast-food consumption. Our findings indicate that availability might not be the dominant factor influencing fast-food consumption. We recommend using subjective availability measures and considering individual characteristics that could influence both perceived availability of fast food and its impact on fast-food consumption. If replicated, our findings suggest that interventions aimed at reducing fast-food consumption by limiting neighborhood fast-food availability might not be completely effective

  17. Serum Lipid Profile: Fasting or Non-fasting?

    OpenAIRE

    Nigam, P. K.

    2010-01-01

    Serum lipid profile has now become almost a routine test. It is usually done in fasting state due to certain limitations in non-fasting serum sample. In the recent past efforts have been made to simplify blood sampling by replacing fasting lipid profile with non-fasting lipid profile. However, fasting specimen is preferred if cardiovascular risk assessment is based on total cholesterol, LDL cholesterol or non-HDL cholesterol. A lot has yet to be done in this area. Till then we have to believe...

  18. Hispanics in Fast Food Jobs.

    Science.gov (United States)

    Charner, Ivan; Fraser, Bryna Shore

    A study examined the employment of Hispanics in the fast-food industry. Data were obtained from a national survey of employees at 279 fast-food restaurants from seven companies in which 194 (4.2 percent) of the 4,660 respondents reported being Hispanic. Compared with the total sample, Hispanic fast-food employees were slightly less likely to be…

  19. Fast reactors: potential for power

    International Nuclear Information System (INIS)

    1983-02-01

    The subject is discussed as follows: basic facts about conventional and fast reactors; uranium economy; plutonium and fast reactors; cooling systems; sodium coolant; safety engineering; handling and recycling plutonium; safeguards; development of fast reactors in Britain and abroad; future progress. (U.K.)

  20. Fast reactors in nuclear power

    Energy Technology Data Exchange (ETDEWEB)

    Kazachkovskii, O

    1981-02-01

    The possible applications are discussed of fast reactor nuclear power plants. Basic differences are explained in fast and thermal reactors, mainly with a view to nuclear fuel utilization. Discussed in more detail are the problems of nuclear fuel reproduction and the nost important technical problems of fast reactors. Flow charts are shown of heat transfer for fast reactors BN-350 (loop design) and BN-600 (integral coolant circuit design). Main specifications are given for demonstration and power fast reactors in operation, under construction and in project-stage.

  1. Knowledge management in fast reactors

    International Nuclear Information System (INIS)

    Kuriakose, K.K.; Satya Murty, S.A.V.; Swaminathan, P.; Raj, Baldev

    2010-01-01

    This paper highlights the work that is being carried out in Knowledge Management of Fast Reactors at Indira Gandhi Centre for Atomic Research (IGCAR) including a few examples of how the knowledge acquired because of various incidents in the initial years has been utilized for the successful operation of Fast Breeder Test Reactor. It also briefly refers to the features of the IAEA initiative on the preservation of Knowledge in the area of Fast Reactors in the form of 'Fast Reactor Knowledge Organization System' (FR-KOS), which is based on a taxonomy for storage and mining of Fast Reactor Knowledge. (author)

  2. Fast photomultiplier ELUP 151

    International Nuclear Information System (INIS)

    Andreeva, L.I.; Belokon', V.A.; Krasin, E.V.

    1992-01-01

    High-velocity photomultiplier is described. The latter is recommended to be used in nuclear physics, plasma physics, nuclear medical diagnostics and at measurement of fast-occurring process parameters. Main specifications are as follows: range of spectral sensitivity - 0.2-0.7 μm; limit of dinamic characteristic linearity - up to 5A; dark current at +20 deg C ambient temperature - maximum 10-8A, time of anode pulse growth - maximum 8 ns; photocathode quantum yield in the maximum of spectral characteristic (λ max =380-420 nm) - 24-26%; supply voltage - 4-5 kV

  3. Fast neutron dosimetry

    International Nuclear Information System (INIS)

    DeLuca, P.M. Jr.; Pearson, D.W.

    1992-01-01

    This progress report concentrates on two major areas of dosimetry research: measurement of fast neutron kerma factors for several elements for monochromatic and white spectrum neutron fields and determination of the response of thermoluminescent phosphors to various ultra-soft X-ray energies and beta-rays. Dr. Zhixin Zhou from the Shanghai Institute of Radiation Medicine, People's Republic of China brought with him special expertise in the fabrication and use of ultra-thin TLD materials. Such materials are not available in the USA. The rather unique properties of these materials were investigated during this grant period

  4. The fast encryption package

    Science.gov (United States)

    Bishop, Matt

    1988-01-01

    The organization of some tools to help improve passwork security at a UNIX-based site is described along with how to install and use them. These tools and their associated library enable a site to force users to pick reasonably safe passwords (safe being site configurable) and to enable site management to try to crack existing passworks. The library contains various versions of a very fast implementation of the Data Encryption Standard and of the one-way encryption functions used to encryp the password.

  5. Fast breeder reactors

    International Nuclear Information System (INIS)

    Ollier, J.L.

    1987-01-01

    The first industrial-scale fast breeder reactor (FBR) is the Superphenix I at Crays-Melville. It was designed and built by Novatome, a French company, and Ansaldo, an Italian company. The advantages of FBRs are summarized. The status of Superphenix and the testing schedule is given. The stages in its power escalation in 1986 are given. The article is optimistic about the future for FBRs and expects FBRs to take over from PWRs at the beginning of the 21st Century. To achieve economic viability, European financial cooperation for the research and development programme is advocated. (UK)

  6. Sodium cooled fast reactor

    Energy Technology Data Exchange (ETDEWEB)

    Hokkyo, N; Inoue, K; Maeda, H

    1968-11-21

    In a sodium cooled fast neutron reactor, an ultrasonic generator is installed at a fuel assembly hold-down mechanism positioned above a blanket or fission gas reservoir located above the core. During operation of the reactor an ultrsonic wave of frequency 10/sup 3/ - 10/sup 4/ Hz is constantly transmitted to the core to resonantly inject the primary bubble with ultrasonic energy to thereby facilitate its growth. Hence, small bubbles grow gradually to prevent the sudden boiling of sodium if an accident occurs in the cooling system during operation of the reactor.

  7. Fast multichannel scaler

    International Nuclear Information System (INIS)

    Okayasu, T.; Takeuchi, S.; Nagai, S.

    1987-01-01

    A fast multichannel scaler achieving the minimum dwell time of 50 ns is described. The dead time due to memory cycle is eliminated by 4-phase operation of parallel-4 groups of counter RAMs. The MCS has 4 k channels in total. Differential nonlinearity is less than 0.4%. If an input pulse arrives near the channel boundary, it is caught temporarily for both channels and then sorted to go into a proper channel. Thus, the dead time near the channel boundary is also eliminated

  8. Fast delta Hadamard transform

    International Nuclear Information System (INIS)

    Fenimore, E.E.; Weston, G.S.

    1981-01-01

    In many fields (e.g., spectroscopy, imaging spectroscopy, photoacoustic imaging, coded aperture imaging) binary bit patterns known as m sequences are used to encode (by multiplexing) a series of measurements in order to obtain a larger throughput. The observed measurements must be decoded to obtain the desired spectrum (or image in the case of coded aperture imaging). Decoding in the past has used a technique called the fast Hadamard transform (FHT) whose chief advantage is that it can reduce the computational effort from N 2 multiplies of N log 2 N additions or subtractions. However, the FHT has the disadvantage that it does not readily allow one to sample more finely than the number of bits used in the m sequence. This can limit the obtainable resolution and cause confusion near the sample boundaries (phasing errors). Both 1-D and 2-D methods (called fast delta Hadamard transforms, FDHT) have been developed which overcome both of the above limitations. Applications of the FDHT are discussed in the context of Hadamard spectroscopy and coded aperture imaging with uniformly redundant arrays. Special emphasis has been placed on how the FDHT can unite techniques used by both of these fields into the same mathematical basis

  9. Fast Fourier transform telescope

    International Nuclear Information System (INIS)

    Tegmark, Max; Zaldarriaga, Matias

    2009-01-01

    We propose an all-digital telescope for 21 cm tomography, which combines key advantages of both single dishes and interferometers. The electric field is digitized by antennas on a rectangular grid, after which a series of fast Fourier transforms recovers simultaneous multifrequency images of up to half the sky. Thanks to Moore's law, the bandwidth up to which this is feasible has now reached about 1 GHz, and will likely continue doubling every couple of years. The main advantages over a single dish telescope are cost and orders of magnitude larger field-of-view, translating into dramatically better sensitivity for large-area surveys. The key advantages over traditional interferometers are cost (the correlator computational cost for an N-element array scales as Nlog 2 N rather than N 2 ) and a compact synthesized beam. We argue that 21 cm tomography could be an ideal first application of a very large fast Fourier transform telescope, which would provide both massive sensitivity improvements per dollar and mitigate the off-beam point source foreground problem with its clean beam. Another potentially interesting application is cosmic microwave background polarization.

  10. The integral fast reactor

    International Nuclear Information System (INIS)

    Till, C.E.

    1987-01-01

    On April 3rd, 1986, two dramatic demonstrations of the inherent capability of sodium-cooled fast reactors to survive unprotected loss of cooling accidents were carried out on the experimental sodium-cooled power reactor, EBR-II, on the Idaho site of Argonne National Laboratory. Transients potentially of the most serious kind, one an unprotected loss of flow, the other an unprotected loss of heat sink, both initiated from full power. In both cases the reactor quietly shut itself down, without damage of any kind. These tests were a part of the on-going development program at Argonne to develop an advanced reactor with significant new inherent safety characteristics. Called the Integral Fast Reactor, or IFR, the basic thrust is to develop everything that is needed for a complete nuclear power system - reactor, closed fuel cycle, and waste processing - as a single optimized entity, and, for simplicity in concept, as an integral part of a single plant. The particular selection of reactor materials emphasizes inherent safety characteristics and also makes possible a simplified closed fuel cycle and waste process improvements

  11. The integral fast reactor

    International Nuclear Information System (INIS)

    Till, C.E.

    1987-01-01

    On April 3rd, 1986, two demonstrations of the inherent capability of sodium-cooled fast reactors to survive unprotected loss of cooling accidents were carried out on the experimental sodium-cooled power reactor, EBR-II, on the Idaho site of Argonne National Laboratory. Transients potentially of the most serious kind, one an unprotected loss of flow, the other an unprotected loss of heat sink, both initiated from full power. In both cases the reactor quietly shut itself down, without damage of any kind. These tests were a part of the on-going development program at Argonne to develop an advanced reactor with significant new inherent safety characteristics. Called the integral fast reactor, or IFR, the basic thrust is to develop everything that is needed for a complete nuclear power system - reactor, closed fuel cycle, and waste processing - as a single optimized entity, and, for simplicity in concept, as an integral part of a single plant. The particular selection of reactor materials emphasizes inherent safety characteristics also makes possible a simplified close fuel cycle and waste process improvements. The paper describes the IFR concept, the inherent safety, tests, and status of IFR development today

  12. Islamic fasting and multiple sclerosis

    Science.gov (United States)

    2014-01-01

    Background Month-long daytime Ramadan fasting pose s major challenges to multiple sclerosis (MS) patients in Muslim countries. Physicians should have practical knowledge on the implications of fasting on MS. We present a summary of database searches (Cochrane Database of Systematic Reviews, PubMed) and a mini-symposium on Ramadan fasting and MS. In this symposium, we aimed to review the effect of fasting on MS and suggest practical guidelines on management. Discussion In general, fasting is possible for most stable patients. Appropriate amendment of drug regimens, careful monitoring of symptoms, as well as providing patients with available evidence on fasting and MS are important parts of management. Evidence from experimental studies suggests that calorie restriction before disease induction reduces inflammation and subsequent demyelination and attenuates disease severity. Fasting does not appear to have unfavorable effects on disease course in patients with mild disability (Expanded Disability Status Scale (EDSS) score ≤3). Most experts believed that during fasting (especially in summer), some MS symptoms (fatigue, fatigue perception, dizziness, spasticity, cognitive problems, weakness, vision, balance, gait) might worsen but return to normal levels during feasting. There was a general consensus that fasting is not safe for patients: on high doses of anti-convulsants, anti-spastics, and corticosteroids; with coagulopathy or active disease; during attacks; with EDSS score ≥7. Summary These data suggest that MS patients should have tailored care. Fasting in MS patients is a challenge that is directly associated with the spiritual belief of the patient. PMID:24655543

  13. Fast Food Jobs. National Study of Fast Food Employment.

    Science.gov (United States)

    Charner, Ivan; Fraser, Bryna Shore

    A study examined employment in the fast-food industry. The national survey collected data from employees at 279 fast-food restaurants from seven companies. Female employees outnumbered males by two to one. The ages of those fast-food employees in the survey sample ranged from 14 to 71, with fully 70 percent being in the 16- to 20-year-old age…

  14. Materials analysis fast ions

    CERN Document Server

    Denker, A; Rauschenberg, J; Röhrich, J; Strub, E

    2006-01-01

    Materials analysis with ion beams exploits the interaction of ions with the electrons and nuclei in the sample. Among the vast variety of possible analytical techniques available with ion beams we will restrain to ion beam analysis with ion beams in the energy range from one to several MeV per mass unit. It is possible to use either the back-scattered projectiles (RBS – Rutherford Back Scattering) or the recoiled atoms itself (ERDA – Elastic Recoil Detection Analysis) from the elastic scattering processes. These techniques allow the simultaneous and absolute determination of stoichiometry and depth profiles of the detected elements. The interaction of the ions with the electrons in the sample produces holes in the inner electronic shells of the sample atoms, which recombine and emit X-rays characteristic for the element in question. Particle Induced X-ray Emission (PIXE) has shown to be a fast technique for the analysis of elements with an atomic number above 11.

  15. Fast multilevel radiative transfer

    International Nuclear Information System (INIS)

    Paletou, Frederic; Leger, Ludovick

    2007-01-01

    The vast majority of recent advances in the field of numerical radiative transfer relies on approximate operator methods better known in astrophysics as Accelerated Lambda-Iteration (ALI). A superior class of iterative schemes, in term of rates of convergence, such as Gauss-Seidel and successive overrelaxation methods were therefore quite naturally introduced in the field of radiative transfer by Trujillo Bueno and Fabiani Bendicho [A novel iterative scheme for the very fast and accurate solution of non-LTE radiative transfer problems. Astrophys J 1995;455:646]; it was thoroughly described for the non-LTE two-level atom case. We describe hereafter in details how such methods can be generalized when dealing with non-LTE unpolarised radiation transfer with multilevel atomic models, in monodimensional geometry

  16. Fast reactor programme

    International Nuclear Information System (INIS)

    Hoekstra, E.K.

    1976-11-01

    Estimated reactivity effects of fission products in the SNR-300 fast breeder are given. Neutron cross sections of 127 I and 129 I are also given. Results of the in-pile canning failure experiments on fuel pins R54-F35 and F39 are discussed. Sinter experiments using mixed UC-UN powders are reported. Results of tensile tests on high-dose and low-dose irradiated specimens of 18Cr1 1Ni stainless steel (DIN 1.4948) used in the SNR-300 reactor vessel are given. It is shown that the aerosol behaviour in condensing sodium vapour can be described by the same MADCA model developed for the decay of aerosols in condensing water vapour. Results of heat transfer measurements in the electrically heated 28-rod bundle under liquid-phase and subsequently under two-phase conditions are commented on

  17. The Integral Fast Reactor

    International Nuclear Information System (INIS)

    Till, C.E.

    1985-01-01

    During the past two years, scientists from Argonne have developed an advanced breeder reactor with a closed self contained fuel cycle. The Integral Fast Reactor (IFR) is a new reactor concept, adaptable to a variety of designs, that is based on a fuel cycle radically different from the CRBR line of breeder development. The essential features of the IFR are metal fuel, pool layout, and pyro- and electro-reprocessing in a facility integral with the reactor plant. The IFR shows promise to provide an inexhaustible, safe, economic, environmentally acceptable, and diversion resistant source of nuclear power. It shows potential for major improvement in all of the areas that have led to concern about nuclear power

  18. Fast reactors and nonproliferation

    International Nuclear Information System (INIS)

    Orlov, V.V.

    1997-01-01

    1.Three aspects of nonproliferation relevant to nuclear power are: Pu buildup in NPP spent fuel cooling ponds (∼ 104 t in case of consumption of ∼ 107 t cheap uranium). Danger of illegal radiochemical extraction of Pu for weapons production; Pu extraction from NPP fuel at the plants available in nuclear countries, its burning along with weapon-grade Pu in NPP reactors or in special-purpose burners; increased hazard of nuclear weapons sprawl with breeders and closed fuel cycle technology spreading all over the world. 2.The latter is one of major obstacles to creation of large-scale nuclear power. 3.Nuclear power of the first stage using 235 U will be able to meet the demands of certain fuel-deficient countries and regions, replacing ∼ 5-10% of conventional fuels in the global consumption for a number of decades. 4.Fast reactors of the first generation and the currently employed fuel technology are far from exhausting their potential for solving economic problems and meeting the challenges of safety, radioactive waste and nonproliferation. Development of large-scale nuclear power will become an option accepted by society for solving energy problems in the following century, provided a breeder technology is elaborated and demonstrated in the next 15-20 years, which would comply with the totality of the following requirement: full internal Pu breeding deterministic elimination of severe accidents involving fuel damage and high radioactivity releases: fast runaway, loss of coolant, fires, steam and hydrogen explosions, etc.; reaching a balance between radioactive wastes disposed of and uranium mined in terms of radiation hazard; technology of closed fuel cycle preventing its use for Pu extraction and permitting physical protection from fuel thefts;economic competitiveness of nuclear power for most of countries and regions, i.e. primarily the cost of NPPs with fat reactors is to be below the cost of modern LWR plants, etc

  19. Promotion and Fast Food Demand

    OpenAIRE

    Timothy J. Richards; Luis Padilla

    2009-01-01

    Many believe that fast food promotion is a significant cause of the obesity epidemic in North America. Industry members argue that promotion only reallocates brand shares and does not increase overall demand. We study the effect of fast food promotion on market share and total demand by estimating a discrete / continuous model of fast food restaurant choice and food expenditure that explicitly accounts for both spatial and temporal determinants of demand. Estimates are obtained using a unique...

  20. New fast reactor installation concept

    International Nuclear Information System (INIS)

    Anon.

    1976-01-01

    The large size and complexity of fast reactor installations are emphasised and these difficulties will be increased with the advent of fast reactors of higher power. In this connection a new concept of fast reactor installation is described with a view to reducing the size of the installation and enabling most components, including even the primary vessel, to be constructed within the confines of a workshop. Full constructional details are given. (U.K.)

  1. Fast mixed spectrum reactor concept

    International Nuclear Information System (INIS)

    Kouts, H.J.C.; Fischer, G.J.; Cerbone, R.J.

    1979-04-01

    The Fast Mixed Spectrum Reactor is a highly promising concept for a fast reactor with improved features of proliferation resistance, and excellent utilization of uranium resources. In technology, it can be considered to be a branch of fast breeder development, though its operation and implications are different from those of FBR'S in important respects. Successful development programs are required in several areas to bring FMSR to reality, but the payoff from a successful program can be high

  2. FastChem: An ultra-fast equilibrium chemistry

    Science.gov (United States)

    Kitzmann, Daniel; Stock, Joachim

    2018-04-01

    FastChem is an equilibrium chemistry code that calculates the chemical composition of the gas phase for given temperatures and pressures. Written in C++, it is based on a semi-analytic approach, and is optimized for extremely fast and accurate calculations.

  3. Fast pitch softball injuries.

    Science.gov (United States)

    Meyers, M C; Brown, B R; Bloom, J A

    2001-01-01

    The popularity of fast pitch softball in the US and throughout the world is well documented. Along with this popularity, there has been a concomitant increase in the number of injuries. Nearly 52% of cases qualify as major disabling injuries requiring 3 weeks or more of treatment and 2% require surgery. Interestingly, 75% of injuries occur during away games and approximately 31% of traumas occur during nonpositional and conditioning drills. Injuries range from contusions and tendinitis to ligamentous disorders and fractures. Although head and neck traumas account for 4 to 12% of cases, upper extremity traumas account for 23 to 47% of all injuries and up to 19% of cases involve the knee. Approximately 34 to 42% of injuries occur when the athlete collides with another individual or object. Other factors involved include the quality of playing surface, athlete's age and experience level, and the excessive physical demands associated with the sport. Nearly 24% of injuries involve base running and are due to poor judgement, sliding technique, current stationary base design, unorthodox joint and extremity position during ground impact and catching of cleats. The increasing prevalence of overtraining syndrome among athletes has been attributed to an unclear definition of an optimal training zone, poor communication between player and coach, and the limited ability of bone and connective tissue to quickly respond to match the demands of the sport. This has led routinely to arm, shoulder and lumbar instability, chronic nonsteroidal anti-inflammatory drug (NSAID) use and time loss injuries in 45% of pitching staff during a single season. Specific attention to a safer playing environment, coaching and player education, and sport-specific training and conditioning would reduce the risk, rate and severity of fast pitch traumas. Padding of walls, backstops, rails and dugout areas, as well as minimising use of indoor facilities, is suggested to decrease the number of collision

  4. The polarization of fast neutrons

    International Nuclear Information System (INIS)

    Talov, V.V.

    2000-01-01

    The present work is the review of polarization of fast neutrons and methods of polarization analysis. This also includes information about polarization of fast neutrons from first papers, which described polarization in the D(d,n) 3 He, 7 Li(p,n) 7 Be, and T(p,n) 3 He reactions. (authors)

  5. FastStats: Child Health

    Science.gov (United States)

    ... Women’s Health State and Territorial Data Reproductive Health Contraceptive Use Infertility Reproductive Health Notice Regarding FastStats Mobile ... table 6 [PDF – 2.7 MB] Related FastStats Adolescent Health ADHD Asthma Infant Health More data: reports ...

  6. Fast feedback in classroom practice

    NARCIS (Netherlands)

    Emmett, K.M.; Klaassen, K.; Eijkelhof, H.

    2009-01-01

    In this article we describe one application of the fast feedback method (see Berg 2003 Aust. Sci. Teach. J. 28–34) in secondary mechanics education. Two teachers tried out a particular sequence twice, in consecutive years, once with and once without the use of fast feedback. We found the method to

  7. Uranium and the fast reactor

    International Nuclear Information System (INIS)

    Price, T.

    1982-01-01

    The influence of uranium availability upon the future of the fast reactor is reviewed. The important issues considered are uranium reserves and resources, uranium market prices, fast reactor economics and the political availability of uranium to customers in other countries. (U.K.)

  8. Fasting and nonfasting lipid levels

    DEFF Research Database (Denmark)

    Langsted, Anne; Freiberg, Jacob J; Nordestgaard, Børge G

    2008-01-01

    Lipid profiles are usually measured after fasting. We tested the hypotheses that these levels change only minimally in response to normal food intake and that nonfasting levels predict cardiovascular events.......Lipid profiles are usually measured after fasting. We tested the hypotheses that these levels change only minimally in response to normal food intake and that nonfasting levels predict cardiovascular events....

  9. Oil Analysis by Fast DSC

    NARCIS (Netherlands)

    Wetten, I.A.; Herwaarden, A.W.; Splinter, R.; Ruth, van S.M.

    2014-01-01

    Thermal analysis of Olive and Sunflower Oil is done by Fast DSC to evaluate its potential to replace DSC for adulteration detection. DSC measurements take hours, Fast DSC minutes. Peak temperatures of the crystallisation peak in cooling for different Olive and Sunflower Oils are both comparable to

  10. The safety of fast reactors

    International Nuclear Information System (INIS)

    Justin, F.

    1976-01-01

    A response is made to the main questions that a man in the street may arise concerning fast breeder reactors, in particular: the advantages of this line, dangerous materials contained in fast breeder reactors, containment shells protecting the environment from radiations, main studies now in progress [fr

  11. Fast reactor programme

    International Nuclear Information System (INIS)

    Plakman, J.C.

    1981-06-01

    The accuracy requirements and the status of the evaluated fission-product cross sections for fast reactors are reviewed; the work on calculating the sensitivity of the sodium void effect to fission-product cross sections is described; some results of the intercomparison of adjusted data sets for capture cross sections of fission-products (RCN-2A and CARNAVAL-IV) are discussed; the applicability of the maximum-likelihood method for the analysis of resolved resonance parameters for a large class of fission-product nuclides is demonstrated; the neutron cross sections for corrosion product 64 Ni are evaluated. Some results of post-irradiation examination of a loss-of-cooling experiment are given; the progress in testing the equipment and instrumentation for transient-overpower experiments is reported. The proceedings in the thermochemical investigations on uranium compounds with some fission-products are described. The creep behaviour of a heat of DIN 1.4948 parent metal is investigated with respect to the changes in strain with different test temperatures. Sodium smoke aerosols have been produced and analysed with respect to their aerodynamic behaviour and morphology. The two-phase local boiling experiments have been analysed to find criteria for the occurrence of different boiling regimes with the objection to deduce general dryout correlations

  12. Fast ignition breakeven scaling

    International Nuclear Information System (INIS)

    Slutz, Stephen A.; Vesey, Roger Alan

    2005-01-01

    A series of numerical simulations have been performed to determine scaling laws for fast ignition break even of a hot spot formed by energetic particles created by a short pulse laser. Hot spot break even is defined to be when the fusion yield is equal to the total energy deposited in the hot spot through both the initial compression and the subsequent heating. In these simulations, only a small portion of a previously compressed mass of deuterium-tritium fuel is heated on a short time scale, i.e., the hot spot is tamped by the cold dense fuel which surrounds it. The hot spot tamping reduces the minimum energy required to obtain break even as compared to the situation where the entire fuel mass is heated, as was assumed in a previous study [S. A. Slutz, R. A. Vesey, I. Shoemaker, T. A. Mehlhorn, and K. Cochrane, Phys. Plasmas 7, 3483 (2004)]. The minimum energy required to obtain hot spot break even is given approximately by the scaling law E T = 7.5(ρ/100) -1.87 kJ for tamped hot spots, as compared to the previously reported scaling of E UT = 15.3(ρ/100) -1.5 kJ for untamped hotspots. The size of the compressed fuel mass and the focusability of the particles generated by the short pulse laser determines which scaling law to use for an experiment designed to achieve hot spot break even

  13. Fast liner proposal

    International Nuclear Information System (INIS)

    Sherwood, A.R.; Freeman, B.L.; Gerwin, R.A.; Jarboe, T.R.; Krakowski, R.A.; Malone, R.C.; Marshall, J.; Miller, R.L.; Suydam, B.

    1977-08-01

    This is a proposal to study, both theoretically and experimentally, the possibility of making a fusion reactor by magnetically imploding a cylindrical metallic shell on a prepared plasma. The approach is characterized by the following features: (1) the nonrotating liner would be driven by an axial current, (2) the plasma would also carry an axial current that provides an azimuthal magnetic field for thermal insulation in both the radial and longitudinal directions, (3) solid end plugs would be utilized to prevent axial loss of particles, and (4) liner speeds would be in the 10 6 cm/s range. The preliminary calculations indicate (1) that the energetics are favorable (energy inputs of about 10 MJ might produce a machine in the break-even regime), (2) that radiation and heat losses could be made tolerable, (3) that alpha-particle heating could be made very effective, and (4) that Taylor instabilities in a fast liner might be harmless because of the large viscosities at high pressures. A preliminary conceptual design of the sort of fusion reactor that might result from such an approach is discussed, as are some of the relevant reactor scaling arguments

  14. Fast reactor recharging device

    International Nuclear Information System (INIS)

    Artemiev, L.N.; Kurilkin, V.V.

    1979-01-01

    Disclosure is made of a device for recharging a fast-neutron reactor, intended for the transfer of fuel assemblies and rods of the control and safety system, having profiled heads to be gripped on the outside. The device comprises storage drums whose compartments for rods of the control and safety system are identical to compartments for fuel assemblies. In order to store and transport rods of the control and safety system from the storage drums to the recharging mechanism provision is made for sleeve-type holders. When placed in such a holder, the dimensions of a rod of the control and safety system are equal to those of a fuel assembly. To join a holder to a rod of the control and safety system, on the open end of each holder there is mounted a collet, whereas on the surface of each rod of the control and safety system, close to its head, there is provided an encircling groove to interact with the collet. The grip of the recharging mechanism is provided with a stop interacting with the collet in order to open the latter and withdraw the safety and control system rod from its holder

  15. The ATLAS Fast Tracker

    CERN Document Server

    Volpi, Guido; The ATLAS collaboration

    2015-01-01

    The use of tracking information at the trigger level in the LHC Run II period is crucial for the trigger an data acquisition (TDAQ) system. The tracking precision is in fact important to identify specific decay products of the Higgs boson or new phenomena, a well as to distinguish the contributions coming from many contemporary collisions that occur at every bunch crossing. However, the track reconstruction is among the most demanding tasks performed by the TDAQ computing farm; in fact, full reconstruction at full Level-1 trigger accept rate (100 KHz) is not possible. In order to overcome this limitation, the ATLAS experiment is planning the installation of a specific processor: the Fast Tracker (FTK), which is aimed at achieving this goal. The FTK is a pipeline of high performance electronic, based on custom and commercial devices, which is expected to reconstruct, with high resolution, the trajectories of charged tracks with a transverse momentum above 1 GeV, using the ATLAS inner tracker information. Patte...

  16. Fast breeder fuel cycle

    International Nuclear Information System (INIS)

    1978-07-01

    This contribution is prepared for the answer to the questionnaire of working group 5, subgroup B. B.1. is the short review of the fast breeder fuel cycles based on the reference large commercial Japanese LMFBR. The LMFBRs are devided into two types. FBR-A is the reactor to be used before 2000, and its burnup and breeding ratio are relatively low. The reference fuel cycle requirement is calculated based on the FBR-A. FBR-B is the one to be used after 2000, and its burnup and breeding ratio are relatively high. B.2. is basic FBR fuel reprocessing scheme emphasizing the differences with LWR reprocessing. This scheme is based on the conceptual design and research and development work on the small scale LMFBR reprocessing facility of Japan. The facility adopts a conventional PUREX process except head end portions. The report also describes the effects of technical modifications of conventional reprocessing flow sheets, and the problems to be solved before the adoption of these alternatives

  17. Fast Aerial Video Stitching

    Directory of Open Access Journals (Sweden)

    Jing Li

    2014-10-01

    Full Text Available The highly efficient and robust stitching of aerial video captured by unmanned aerial vehicles (UAVs is a challenging problem in the field of robot vision. Existing commercial image stitching systems have seen success with offline stitching tasks, but they cannot guarantee high-speed performance when dealing with online aerial video sequences. In this paper, we present a novel system which has an unique ability to stitch high-frame rate aerial video at a speed of 150 frames per second (FPS. In addition, rather than using a high-speed vision platform such as FPGA or CUDA, our system is running on a normal personal computer. To achieve this, after the careful comparison of the existing invariant features, we choose the FAST corner and binary descriptor for efficient feature extraction and representation, and present a spatial and temporal coherent filter to fuse the UAV motion information into the feature matching. The proposed filter can remove the majority of feature correspondence outliers and significantly increase the speed of robust feature matching by up to 20 times. To achieve a balance between robustness and efficiency, a dynamic key frame-based stitching framework is used to reduce the accumulation errors. Extensive experiments on challenging UAV datasets demonstrate that our approach can break through the speed limitation and generate an accurate stitching image for aerial video stitching tasks.

  18. Pile oscillator ROB-1, cooperation NPY

    Energy Technology Data Exchange (ETDEWEB)

    Petrovic, M; Markovic, V; Obradovic, D; Kocic, A; Velickovic, LJ; Jovanovic, S [Boris Kidric Institute of nuclear sciences Vinca, Belgrade (Yugoslavia)

    1965-11-15

    The present paper explains the purpose of the work on reactor kinetics and separately deals with the region for which the ROB-1 reactor oscillator is constructed. The theoretical part concerns the basic principles on which the oscillator operates. the paper also discusses the details of the oscillator, the procedure for preparation and measurement, and analyzes the source of errors. In addition several examples of the use of oscillator are given. (author)

  19. Pile oscillator ROB-1, cooperation NPY

    International Nuclear Information System (INIS)

    Petrovic, M.; Markovic, V.; Obradovic, D.; Kocic, A.; Velickovic, LJ.; Jovanovic, S.

    1965-11-01

    The present paper explains the purpose of the work on reactor kinetics and separately deals with the region for which the ROB-1 reactor oscillator is constructed. The theoretical part concerns the basic principles on which the oscillator operates. the paper also discusses the details of the oscillator, the procedure for preparation and measurement, and analyzes the source of errors. In addition several examples of the use of oscillator are given. (author)

  20. Fast-prototyping of VLSI

    International Nuclear Information System (INIS)

    Saucier, G.; Read, E.

    1987-01-01

    Fast-prototyping will be a reality in the very near future if both straightforward design methods and fast manufacturing facilities are available. This book focuses, first, on the motivation for fast-prototyping. Economic aspects and market considerations are analysed by European and Japanese companies. In the second chapter, new design methods are identified, mainly for full custom circuits. Of course, silicon compilers play a key role and the introduction of artificial intelligence techniques sheds a new light on the subject. At present, fast-prototyping on gate arrays or on standard cells is the most conventional technique and the third chapter updates the state-of-the art in this area. The fourth chapter concentrates specifically on the e-beam direct-writing for submicron IC technologies. In the fifth chapter, a strategic point in fast-prototyping, namely the test problem is addressed. The design for testability and the interface to the test equipment are mandatory to fulfill the test requirement for fast-prototyping. Finally, the last chapter deals with the subject of education when many people complain about the lack of use of fast-prototyping in higher education for VLSI

  1. FAST MRI breast screening revisited

    International Nuclear Information System (INIS)

    Jain, Manish; Jain, Arushi; Hyzy, Marek D.; Werth, Graziella

    2017-01-01

    Screening for breast cancer in high-risk women takes about 40 minutes to acquire an MRI scan and is time-intensive to report. There is recent interest in the performance of an abbreviated MRI protocol (FAST) in the screening setting. FAST scans have a reported negative predictive value of 99.8%. This study evaluates the false positive rates (FPR) and recall rates for FAST scans as compared to full diagnostic studies (FD). A database of all screening breast MRI scans performed at our institution between 30 June 2013 and 1 July 2014 (n = 591) was created by one of the researchers, who did not subsequently analyse the MRI scans. The T1W and first post-contrast and subtracted images from each of these scans (FAST protocol) were assessed by experienced breast MRI radiologists, blinded to the final diagnosis. The findings were then compared with the FD result. The recall rates were 6.6% for FAST scans and 5.8% for FD scans. FPR rates were 4.7% and 3.9% respectively. There is no statistically significant difference in the recall rates or FPR of FAST scans in comparison with full diagnostic studies. Given the absence of statistically significant difference in the FPR and recall rates in comparison with FD, FAST scans can replace FD for screening of breast cancer.

  2. Fast food: unfriendly and unhealthy.

    Science.gov (United States)

    Stender, S; Dyerberg, J; Astrup, A

    2007-06-01

    Although nutrition experts might be able to navigate the menus of fast-food restaurant chains, and based on the nutritional information, compose apparently 'healthy' meals, there are still many reasons why frequent fast-food consumption at most chains is unhealthy and contributes to weight gain, obesity, type 2 diabetes and coronary artery disease. Fast food generally has a high-energy density, which, together with large portion sizes, induces over consumption of calories. In addition, we have found it to be a myth that the typical fast-food meal is the same worldwide. Chemical analyses of 74 samples of fast-food menus consisting of French fries and fried chicken (nuggets/hot wings) bought in McDonalds and KFC outlets in 35 countries in 2005-2006 showed that the total fat content of the same menu varies from 41 to 65 g at McDonalds and from 42 to 74 g at KFC. In addition, fast food from major chains in most countries still contains unacceptably high levels of industrially produced trans-fatty acids (IP-TFA). IP-TFA have powerful biological effects and may contribute to increased weight gain, abdominal obesity, type 2 diabetes and coronary artery disease. The food quality and portion size need to be improved before it is safe to eat frequently at most fast-food chains.

  3. Fast reactor physics - an overview

    International Nuclear Information System (INIS)

    Lee, S.M.

    2004-01-01

    An introduction to the basic features of fast neutron reactors is made, highlighting the differences from the more conventional thermal neutron reactors. A discussion of important feedback reactivity mechanisms is given. Then an overview is presented of the methods of fast reactor physics, which play an important role in the successful design and operation of fast reactors. The methods are based on three main elements, namely (i) nuclear data bases, (ii) numerical methods and computer codes, and (iii) critical experiments. These elements are reviewed and the present status and future trends are summarized. (author)

  4. [Fast food promotes weight gain].

    Science.gov (United States)

    Stender, Steen; Dyerberg, Jørn; Astrup, Arne V

    2007-05-07

    The total amounts of fat in a fast food menu consisting of French fries and fried Chicken Nuggets from McDonald's and KFC, respectively, bought in 35 different countries vary from 41 to 71 gram. In most countries the menu contained unacceptably high amounts of industrially-produced trans fat which contributes to an increased risk of ischaemic heart disease, weight gain, abdominal fat accumulation and type 2 diabetes. The quality of the ingredients in fast food ought to be better and the size of the portions smaller and less energy-dense so that frequent fast food meals do not increase the risk of obesity and diseases among customers.

  5. FastStats: Contraceptive Use

    Science.gov (United States)

    ... Growth (data are for 2011-2015) Related FastStats Infertility Reproductive Health More data Condom Use During Sexual Intercourse Among Females and Males 15-44 in the United States [PDF – 430 ...

  6. Fast global sequence alignment technique

    KAUST Repository

    Bonny, Mohamed Talal; Salama, Khaled N.

    2011-01-01

    fast alignment algorithm, called 'Alignment By Scanning' (ABS), to provide an approximate alignment of two DNA sequences. We compare our algorithm with the wellknown sequence alignment algorithms, the 'GAP' (which is heuristic) and the 'Needleman

  7. Allegheny County Fast Food Establishments

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — The Allegheny County Health Department has generated this list of fast food restaurants by exporting all chain restaurants without an alcohol permit from the...

  8. FastStats: Mental Health

    Science.gov (United States)

    ... Women’s Health State and Territorial Data Reproductive Health Contraceptive Use Infertility Reproductive Health Notice Regarding FastStats Mobile ... Use of Selected Nonmedication Mental Health Services by Adolescent Boys and Girls With Serious Emotional or Behavioral ...

  9. Fast neutron spectrometry and dosimetry

    International Nuclear Information System (INIS)

    Blaize, S.; Ailloud, J.; Mariani, J.; Millot, J.P.

    1958-01-01

    We have studied fast neutron spectrometry and dosimetry through the recoil protons they produce in hydrogenated samples. In spectrometric, we used nuclear emulsions, in dosimetric, we used polyethylene coated with zinc sulphide and placed before a photomultiplier. (author) [fr

  10. The Fast Theater Model (FATHM)

    National Research Council Canada - National Science Library

    Brown, Gerald G; Washburn, Alan R

    2002-01-01

    The Fast Theater Model (FATHM) is an aggregated joint theater combat model that fuses Air Force Air-to-Ground attack sortie optimization with Ground-to-Ground deterministic Lanchester fire-exchange battles using attrition rates...

  11. The price of fast fashion

    Science.gov (United States)

    2018-01-01

    The fashion industry has changed rapidly in recent years with the increased prevalence of fast fashion, impacting the environment. Efforts to green this polluting industry require action from businesses and consumers.

  12. FastStats: Body Measurements

    Science.gov (United States)

    ... this? Submit What's this? Submit Button NCHS Home Body Measurements Recommend on Facebook Tweet Share Compartir Data ... 7 MB] Related FastStats Obesity/Overweight Related Links Body Mass Index table CDC Growth Charts National Health ...

  13. Fast generation of dendritic cells

    DEFF Research Database (Denmark)

    Kvistborg, P; Bøgh, Marie; Pedersen, A W

    2009-01-01

    we have developed fast DC protocol by comparing two different fast DC protocols with SDDC. DC were evaluated by FACS analysis, and the optimal profile was considered: CD14(low), CD80(high), CD83(high), CD86(high), CCR7(high), HLA class I and II(high). FACS profiles were used as the selection criteria...... together with yield and morphology. Two fast DC protocols fulfilled these criteria and were selected for functional analysis. Our results demonstrate that DC generated within 5days or 48h are comparable with SDDC both phenotypically and functionally. However, we found that 48h DC were more susceptible than...... SDDC to the IL-10 inducing stimulus of TLR ligands (R848 and LPS). Thus to determine the clinical relevance of fast DC protocols in cancer settings, small phase I trials should be conducted monitoring regulatory T cells carefully....

  14. Contraband detection with fast neutrons

    Energy Technology Data Exchange (ETDEWEB)

    Buffler, Andy E-mail: abuffler@science.uct.ac.za

    2004-11-01

    Recent terror events and the increase in the trade of illicit drugs have fuelled the exploration of the use of fast neutrons as probes for the detection of hidden contraband, especially explosives, in packages ranging in size from small mail items to cargo containers. The various approaches using fast neutrons for contraband detection, presently under development, are reviewed. The role that a neutron system might play in the non-intrusive interrogation of airline luggage is discussed.

  15. Review of fast reactor activities

    International Nuclear Information System (INIS)

    1982-01-01

    A description of some highlights of the activities performed by the Commission of the European Communities in the field of fast reactors is given. They fall into two categories: coordinating and harmonizing activities and research activities. The former are essentially performed in the frame of the Fast Reactor Coordinating Committee (FRCC), the latter in the Commission's Joint Research Center and to some extent under contract in research centers of the Member States

  16. Upgrading ATLAS Fast Calorimeter Simulation

    CERN Document Server

    Heath, Matthew Peter; The ATLAS collaboration

    2017-01-01

    Producing the very large samples of simulated events required by many physics and performance studies with the ATLAS detector using the full GEANT4 detector simulation is highly CPU intensive. Fast simulation tools are a useful way of reducing CPU requirements when detailed detector simulations are not needed. During the LHC Run-1, a fast calorimeter simulation (FastCaloSim) was successfully used in ATLAS. FastCaloSim provides a simulation of the particle energy response at the calorimeter read-out cell level, taking into account the detailed particle shower shapes and the correlations between the energy depositions in the various calorimeter layers. It is interfaced to the standard ATLAS digitization and reconstruction software, and it can be tuned to data more easily than Geant4. Now an improved version of FastCaloSim is in development, incorporating the experience with the version used during Run-1. The new FastCaloSim aims to overcome some limitations of the first version by improving the description of s...

  17. Direct Fast-Neutron Detection

    International Nuclear Information System (INIS)

    DC Stromswold; AJ Peurrung; RR Hansen; PL Reeder

    2000-01-01

    Direct fast-neutron detection is the detection of fast neutrons before they are moderated to thermal energy. We have investigated two approaches for using proton-recoil in plastic scintillators to detect fast neutrons and distinguish them from gamma-ray interactions. Both approaches use the difference in travel speed between neutrons and gamma rays as the basis for separating the types of events. In the first method, we examined the pulses generated during scattering in a plastic scintillator to see if they provide a means for distinguishing fast-neutron events from gamma-ray events. The slower speed of neutrons compared to gamma rays results in the production of broader pulses when neutrons scatter several times within a plastic scintillator. In contrast, gamma-ray interactions should produce narrow pulses, even if multiple scattering takes place, because the time between successive scattering is small. Experiments using a fast scintillator confirmed the presence of broader pulses from neutrons than from gamma rays. However, the difference in pulse widths between neutrons and gamma rays using the best commercially available scintillators was not sufficiently large to provide a practical means for distinguishing fast neutrons and gamma rays on a pulse-by-pulse basis. A faster scintillator is needed, and that scintillator might become available in the literature. Results of the pulse-width studies were presented in a previous report (peurrung et al. 1998), and they are only summarized here

  18. Fast Calorimeter Simulation in ATLAS

    CERN Document Server

    Schaarschmidt, Jana; The ATLAS collaboration

    2017-01-01

    Producing the very large samples of simulated events required by many physics and performance studies with the ATLAS detector using the full GEANT4 detector simulation is highly CPU intensive. Fast simulation tools are a useful way of reducing CPU requirements when detailed detector simulations are not needed. During the LHC Run-1, a fast calorimeter simulation (FastCaloSim) was successfully used in ATLAS. FastCaloSim provides a simulation of the particle energy response at the calorimeter read-out cell level, taking into account the detailed particle shower shapes and the correlations between the energy depositions in the various calorimeter layers. It is interfaced to the standard ATLAS digitization and reconstruction software, and it can be tuned to data more easily than GEANT4. It is 500 times faster than full simulation in the calorimeter system. Now an improved version of FastCaloSim is in development, incorporating the experience with the version used during Run-1. The new FastCaloSim makes use of mach...

  19. Fast reactor database. 2006 update

    International Nuclear Information System (INIS)

    2006-12-01

    Liquid metal cooled fast reactors (LMFRs) have been under development for about 50 years. Ten experimental fast reactors and six prototype and commercial size fast reactor plants have been constructed and operated. In many cases, the overall experience with LMFRs has been rather good, with the reactors themselves and also the various components showing remarkable performances, well in accordance with the design expectations. The fast reactor system has also been shown to have very attractive safety characteristics, resulting to a large extent from the fact that the fast reactor is a low pressure system with large thermal inertia and negative power and temperature coefficients. In addition to the LMFRs that have been constructed and operated, more than ten advanced LMFR projects have been developed, and the latest designs are now close to achieving economic competitivity with other reactor types. In the current world economic climate, the introduction of a new nuclear energy system based on the LMFR may not be considered by utilities as a near future option when compared to other potential power plants. However, there is a strong agreement between experts in the nuclear energy field that, for sustainability reasons, long term development of nuclear power as a part of the world's future energy mix will require the fast reactor technology, and that, given the decline in fast reactor development projects, data retrieval and knowledge preservation efforts in this area are of particular importance. This publication contains detailed design data and main operational data on experimental, prototype, demonstration, and commercial size LMFRs. Each LMFR plant is characterized by about 500 parameters: physics, thermohydraulics, thermomechanics, by design and technical data, and by relevant sketches. The focus is on practical issues that are useful to engineers, scientists, managers, university students and professors with complete technical information of a total of 37 LMFR

  20. FAST: An advanced code system for fast reactor transient analysis

    International Nuclear Information System (INIS)

    Mikityuk, Konstantin; Pelloni, Sandro; Coddington, Paul; Bubelis, Evaldas; Chawla, Rakesh

    2005-01-01

    One of the main goals of the FAST project at PSI is to establish a unique analytical code capability for the core and safety analysis of advanced critical (and sub-critical) fast-spectrum systems for a wide range of different coolants. Both static and transient core physics, as well as the behaviour and safety of the power plant as a whole, are studied. The paper discusses the structure of the code system, including the organisation of the interfaces and data exchange. Examples of validation and application of the individual programs, as well as of the complete code system, are provided using studies carried out within the context of designs for experimental accelerator-driven, fast-spectrum systems

  1. Preoperative fasting time in children.

    LENUS (Irish Health Repository)

    Adeel, S

    2012-02-01

    The aim of preoperative fasting is to prevent regurgitation and pulmonary aspiration while limiting potential problems of thirst, dehydration and hypoglycaemia. The American Society of Anaesthesiologists (ASA) has suggested guidelines for preoperative fasting for children undergoing elective surgery. We did a postal survey to determine the current practice regarding these guidelines amongst all specialist registrars in anaesthesia in Ireland. A questionnaire was sent to all specialist registrars in anaesthesia (90 in total), 60 (67%) were returned and analysed. The question asked was how long children should be kept fasting before elective surgery. The results of our survey suggest that most of the respondents are following the ASA guidelines for clear fluids and solids however there were differing opinion regarding the duration of fasting for formula milk and breast milk. In conclusion, we would recommend greater awareness and collaboration between anaesthetists, nurses and surgeons to ensure that fasting instructions are consistent with the ASA guidelines and that patient and their parents understand these directives as well.

  2. Review of fast reactor activities in India

    International Nuclear Information System (INIS)

    Paranjpe, S.R.

    1982-01-01

    A review of fast reactor activities in India is introduced. One stage of construction of the Fast Breeder Test Reactor (FBTR) and design studies for 500MWe Prototype Fast Breeder Reactor (PFBR) are briefly summarized. The emphasis is on fast reactor physics, materials studies, radiochemistry, and the safety and fuel reprocessing programme

  3. Observations of fast variable objects

    International Nuclear Information System (INIS)

    Alekseev, G.N.

    1978-01-01

    A problem on studying fast variable astronomic objects is considered. The basis of the method used in the experiment is a detailed photoelectric study of a fast variableness along with spectroscopy of a high time resolution. Power spectrum of the SS Cyg brightness oscillations and autocorrelation function of the AX Mon brightness are analyzed as an example. To provide a reliable identification of parameters of star active regions responsible for the fast variableness, an experiment is proposed, the ''synchronous spectroscopy'' method being used. The method is based on the supposition about temporary stationarity of occasional processes within the limits of the time scale of several hours. The block diagram of the experiment is described

  4. Review of fast reactor activities

    Energy Technology Data Exchange (ETDEWEB)

    Balz, W [Commission of the European Communities, Brussels (Belgium)

    1978-07-01

    The Commission of the European Communities continued its activities on the following lines: activities aimed at preparing for commercialization of fast breeder reactors which are essentially performed in the frame of Fast Reactor Coordinating Committee (FRCC); the execution of its own research program in the Joint Research Center. The report covers activities of the FRCC, of the Safety Working Group (SWG), the Whole Core Accident Code (WAC) subgroup, Containment (CONT) subgroup, Codes and Standards Working Group (CSWG). Research and development activities are concerned with LMFBR safety, subassembly thermal hydraulics, fuel-coolant interactions, post-accident heat removal, dynamic load response, safety related material properties, utilization limits of fast breeder fuels, plutonium and actinide aspects of nuclear fuel cycle.

  5. Fast reactor collaboration in Europe

    International Nuclear Information System (INIS)

    Smith, G.E.I.

    1987-01-01

    Fast reactors have been developed in several European countries, the United Kingdom, France, Germany and Italy. A suggestion to collaborate on fast reactor research and development resulted in an Intergovernmental Memorandum of Understanding signed in 1984 by the UK, France, Germany, Italy and Belgium. Holland was expected to join later. This provided for co-operation between electric utilities, reactor design, research and development companies and fuel cycle companies. Three steering committees have so far been set up, the European fast reactor utilities Group, the European research and development and the European fuel cycle steering committees. Progress on these is detailed. The main areas of technology exchange are listed in the Appendix. The possibility exists for a series of three large demonstration plants to be built in Europe and a fuel reprocessing plant to confirm the reactor system. (U.K.)

  6. Future Assets, Student Talent (FAST)

    Science.gov (United States)

    1992-01-01

    Future Assets, Student Talent (FAST) motivates and prepares talented students with disabilities to further their education and achieve High Tech and professional employment. The FAST program is managed by local professionals, business, and industry leaders; it is modeled after High School High Tech project TAKE CHARGE started in Los Angeles in 1983. Through cooperative efforts of Alabama Department of Education, Vocational Rehabilitation, Adult and Children Services, and the President's Committee on Employment of People with Disabilities, north central Alabama was chosen as the second site for a High School High Tech project. In 1986 local business, industry, education, government agencies, and rehabilitation representatives started FAST. The program objectives and goals, results and accomplishments, and survey results are included.

  7. Review of fast reactor activities

    International Nuclear Information System (INIS)

    Balz, W.

    1978-01-01

    The Commission of the European Communities continued its activities on the following lines: activities aimed at preparing for commercialization of fast breeder reactors which are essentially performed in the frame of Fast Reactor Coordinating Committee (FRCC); the execution of its own research program in the Joint Research Center. The report covers activities of the FRCC, of the Safety Working Group (SWG), the Whole Core Accident Code (WAC) subgroup, Containment (CONT) subgroup, Codes and Standards Working Group (CSWG). Research and development activities are concerned with LMFBR safety, subassembly thermal hydraulics, fuel-coolant interactions, post-accident heat removal, dynamic load response, safety related material properties, utilization limits of fast breeder fuels, plutonium and actinide aspects of nuclear fuel cycle

  8. The polarization of fast neutrons

    International Nuclear Information System (INIS)

    Talov, V.V.

    2001-01-01

    It is insufficient to know coordinates and momentum to describe a state of a neutron. It is necessary to define a spin orientation. As far as it is known from quantum mechanics, a half spin has a projection in the positive direction or in the negative direction. The probability of both projections in an unpolarized beam is equal. If a direction exists, in which the projection is more probably then beam is called polarized in this direction. It is essential to know polarization of neutrons for characteristics of a neutron source, which is emitting it. The question of polarization of fast neutrons came up in 50's. The present work is the review of polarization of fast neutrons and methods of polarization analysis. This also includes information about polarization of fast neutrons from first papers, which described polarization in the D(d,n) 3 He, 7 Li (p,n) 7 Be, T(p,n) 3 He reactions. (authors)

  9. Review of fast reactor activities

    International Nuclear Information System (INIS)

    Haeussermann, W.; Royen, J.

    1978-01-01

    Since 1971, when the Co-ordinating Group on Gas-Cooled Fast reactors Development was set up, the participating countries have maintained an interest in keeping this option as a back-up solution to the sodium cooled fast reactors. Two different concepts were investigated, one based on coated particle type fuel elements and the other on pin type fuel elements. The coated particles studies have been brought to an end, and resources were concentrated on the further development of the pin type concept. The work done in previous years covered design and safety investigations, heat transfer studies and irradiation experiments in thermal reactors

  10. Overview of tritium fast-fission yields

    International Nuclear Information System (INIS)

    Tanner, J.E.

    1981-03-01

    Tritium production rates are very important to the development of fast reactors because tritium may be produced at a greater rate in fast reactors than in light water reactors. This report focuses on tritium production and does not evaluate the transport and eventual release of the tritium in a fast reactor system. However, if an order-of-magnitude increase in fast fission yields for tritium is confirmed, fission will become the dominant production source of tritium in fast reactors

  11. Causes And Effects Of Fast Food

    Directory of Open Access Journals (Sweden)

    Eman Al-Saad

    2015-08-01

    Full Text Available Fast food affects our life in many aspects. In fact There are many reasons that have been shown why people continuing eating fast food while they knew about its negative effects on their health and family because of eating fast food. The commercial advertisements play a major role in consuming fast food. In this research I will focus on causes and effects of eating fast food.

  12. Causes And Effects Of Fast Food

    OpenAIRE

    Eman Al-Saad

    2015-01-01

    Fast food affects our life in many aspects. In fact There are many reasons that have been shown why people continuing eating fast food while they knew about its negative effects on their health and family because of eating fast food. The commercial advertisements play a major role in consuming fast food. In this research I will focus on causes and effects of eating fast food.

  13. Fast data processing with Spark

    CERN Document Server

    Sankar, Krishna

    2015-01-01

    Fast Data Processing with Spark - Second Edition is for software developers who want to learn how to write distributed programs with Spark. It will help developers who have had problems that were too big to be dealt with on a single computer. No previous experience with distributed programming is necessary. This book assumes knowledge of either Java, Scala, or Python.

  14. A fast fractional difference algorithm

    DEFF Research Database (Denmark)

    Jensen, Andreas Noack; Nielsen, Morten Ørregaard

    2014-01-01

    We provide a fast algorithm for calculating the fractional difference of a time series. In standard implementations, the calculation speed (number of arithmetic operations) is of order T 2, where T is the length of the time series. Our algorithm allows calculation speed of order T log...

  15. A Fast Fractional Difference Algorithm

    DEFF Research Database (Denmark)

    Jensen, Andreas Noack; Nielsen, Morten Ørregaard

    We provide a fast algorithm for calculating the fractional difference of a time series. In standard implementations, the calculation speed (number of arithmetic operations) is of order T 2, where T is the length of the time series. Our algorithm allows calculation speed of order T log...

  16. Fast Timing for Collider Detectors

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    Advancements in fast timing particle detectors have opened up new possibilities to design collider detectors that fully reconstruct and separate event vertices and individual particles in the time domain. The applications of these techniques are considered for the physics at HL-LHC.

  17. Fast and Objective MRTD measurement

    NARCIS (Netherlands)

    Jong, A.N. de; Bakker, S.J.M.

    1988-01-01

    Manufacturers and Users of the Thermal Imagers have spent very much time upon the definition and measurement of the generally accepted performance curve: MRTD (Minimum Resolvable Temperature Difference). The need for a cheap and fast, objective measurement method has considerably increased since the

  18. Fast algorithm of track detection

    International Nuclear Information System (INIS)

    Nehrguj, B.

    1980-01-01

    A fast algorithm of variable-slope histograms is proposed, which allows a considerable reduction of computer memory size and is quite simple to carry out. Corresponding FORTRAN subprograms given a triple speed gain have been included in spiral reader data handling software

  19. Enhanced Model for Fast Ignition

    Energy Technology Data Exchange (ETDEWEB)

    Mason, Rodney J. [Research Applications Corporation, Los Alamos, NM (United States)

    2010-10-12

    Laser Fusion is a prime candidate for alternate energy production, capable of serving a major portion of the nation's energy needs, once fusion fuel can be readily ignited. Fast Ignition may well speed achievement of this goal, by reducing net demands on laser pulse energy and timing precision. However, Fast Ignition has presented a major challenge to modeling. This project has enhanced the computer code ePLAS for the simulation of the many specialized phenomena, which arise with Fast Ignition. The improved code has helped researchers to understand better the consequences of laser absorption, energy transport, and laser target hydrodynamics. ePLAS uses efficient implicit methods to acquire solutions for the electromagnetic fields that govern the accelerations of electrons and ions in targets. In many cases, the code implements fluid modeling for these components. These combined features, "implicitness and fluid modeling," can greatly facilitate calculations, permitting the rapid scoping and evaluation of experiments. ePLAS can be used on PCs, Macs and Linux machines, providing researchers and students with rapid results. This project has improved the treatment of electromagnetics, hydrodynamics, and atomic physics in the code. It has simplified output graphics, and provided new input that avoids the need for source code access by users. The improved code can now aid university, business and national laboratory users in pursuit of an early path to success with Fast Ignition.

  20. Fast simulation of ultrasound images

    DEFF Research Database (Denmark)

    Jensen, Jørgen Arendt; Nikolov, Svetoslav

    2000-01-01

    , and a whole image can take a full day. Simulating 3D images and 3D flow takes even more time. A 3D image of 64 by 64 lines can take 21 days, which is not practical for iterative work. This paper presents a new fast simulation method based on the Field II program. In imaging the same spatial impulse response...

  1. The Integral Fast Reactor concept

    International Nuclear Information System (INIS)

    Till, C.E.; Chang, Y.I.

    1986-01-01

    The Integral Fast Reactor (IFR) is an innovative LMR concept, being developed at Argonne National Laboratory, that exploits the inherent properties of liquid metal cooling and metallic fuel to achieve breakthroughs in economics and inherent safety. This paper describes the key features and potential advantages of the IFR concept, its technology development status, fuel cycle economics potential, and its future development path

  2. Fast-Track Teacher Recruitment.

    Science.gov (United States)

    Grant, Franklin Dean

    2001-01-01

    Schools need a Renaissance human-resources director to implement strategic staffing and fast-track teacher-recruitment plans. The HR director must attend to customer satisfaction, candidate supply, web-based recruitment possibilities, stabilization of newly hired staff, retention of veteran staff, utilization of retired employees, and latest…

  3. Fast reactor research in Switzerland

    International Nuclear Information System (INIS)

    Brogli, R.; Hudina, M.; Pelloni, S.; Sigg, B.; Stanculescu, A.

    1998-01-01

    The small Swiss research program on fast reactors serves to further understanding of the role of LMFR for energy production and to convert radioactive waste to more environmentally benign forms. These activities are on the one hand the contribution to the comparison of advanced nuclear systems and bring on the other to our physical and engineers understanding. (author)

  4. Ultra-fast silicon detectors

    Energy Technology Data Exchange (ETDEWEB)

    Sadrozinski, H. F.-W., E-mail: hartmut@scipp.ucsc.edu [Santa Cruz Institute for Particle Physics, UC Santa Cruz, Santa Cruz, CA 95064 (United States); Ely, S.; Fadeyev, V.; Galloway, Z.; Ngo, J.; Parker, C.; Petersen, B.; Seiden, A.; Zatserklyaniy, A. [Santa Cruz Institute for Particle Physics, UC Santa Cruz, Santa Cruz, CA 95064 (United States); Cartiglia, N.; Marchetto, F. [INFN Torino, Torino (Italy); Bruzzi, M.; Mori, R.; Scaringella, M.; Vinattieri, A. [University of Florence, Department of Physics and Astronomy, Sesto Fiorentino, Firenze (Italy)

    2013-12-01

    We propose to develop a fast, thin silicon sensor with gain capable to concurrently measure with high precision the space (∼10 μm) and time (∼10 ps) coordinates of a particle. This will open up new application of silicon detector systems in many fields. Our analysis of detector properties indicates that it is possible to improve the timing characteristics of silicon-based tracking sensors, which already have sufficient position resolution, to achieve four-dimensional high-precision measurements. The basic sensor characteristics and the expected performance are listed, the wide field of applications are mentioned and the required R and D topics are discussed. -- Highlights: •We are proposing thin pixel silicon sensors with 10's of picoseconds time resolution. •Fast charge collection is coupled with internal charge multiplication. •The truly 4-D sensors will revolutionize imaging and particle counting in many applications.

  5. Fast light in atomic media

    International Nuclear Information System (INIS)

    Akulshin, Alexander M; McLean, Russell J

    2010-01-01

    Atomic media have played a major role in studies of fast light. One of their attractive features is the ability to manipulate experimental parameters to control the dispersive properties that determine the group velocity of a propagating light pulse. We give an overview of the experimental methods, based on both linear and nonlinear atom–light interaction, that have produced superluminal propagation in atomic media, and discuss some of the significant theoretical contributions to the issues of pulse preservation and reconciling faster-than-light propagation and the principle of causality. The comparison of storage of light, enhanced Kerr nonlinearity and efficient wave mixing processes in slow and fast light atomic media illustrates their common and distinct features. (review article)

  6. Why are idioms recognized fast?

    Science.gov (United States)

    Tabossi, Patrizia; Fanari, Rachele; Wolf, Kinou

    2009-06-01

    It is an established fact that idiomatic expressions are fast to process. However, the explanation of the phenomenon is controversial. Using a semantic judgment paradigm, where people decide whether a string is meaningful or not, the present experiment tested the predictions deriving from the three main theories of idiom recognition-the lexical representation hypothesis, the idiom decomposition hypothesis, and the configuration hypothesis. Participants were faster at judging decomposable idioms, nondecomposable idioms, and clichés than at judging their matched controls. The effect was comparable for all conventional expressions. The results were interpreted as suggesting that, as posited by the configuration hypothesis, the fact that they are known expressions, rather than idiomaticity, explains their fast recognition.

  7. Spherical Demons: Fast Surface Registration

    Science.gov (United States)

    Yeo, B.T. Thomas; Sabuncu, Mert; Vercauteren, Tom; Ayache, Nicholas; Fischl, Bruce; Golland, Polina

    2009-01-01

    We present the fast Spherical Demons algorithm for registering two spherical images. By exploiting spherical vector spline interpolation theory, we show that a large class of regularizers for the modified demons objective function can be efficiently implemented on the sphere using convolution. Based on the one parameter subgroups of diffeomorphisms, the resulting registration is diffeomorphic and fast – registration of two cortical mesh models with more than 100k nodes takes less than 5 minutes, comparable to the fastest surface registration algorithms. Moreover, the accuracy of our method compares favorably to the popular FreeSurfer registration algorithm. We validate the technique in two different settings: (1) parcellation in a set of in-vivo cortical surfaces and (2) Brodmann area localization in ex-vivo cortical surfaces. PMID:18979813

  8. ATLAS FTK: The Fast Tracker

    CERN Document Server

    T, Iizawa; The ATLAS collaboration

    2014-01-01

    The Fast TracKer (FTK) will perform global track reconstruction after each Level-1 trigger accept to enable the software-based High Level Trigger to have early access to tracking information. FTK is a dedicated processor based on a mixture of advanced technologies. Modern, powerful Field Programmable Gate Arrays (FPGAs) form an important part of the system architecture, and the large level of computing power required for pattern recognition is provided by incorporating standard-cell ASICs named Associative Memory (AM). FTK provides global track reconstruction in the full inner silicon detector in approximately 100 microseconds with resolution comparable to the offline algorithms. It allows a fast and precise detection of the primary and secondary vertex information. The track and vertex information is then used by the High Level Trigger algorithms, allowing highly improved trigger performance for the important signatures such as b-jets. In this paper, the architecture and the hardware development status of FT...

  9. [Preoperative fasting guidelines: an update].

    Science.gov (United States)

    López Muñoz, A C; Busto Aguirreurreta, N; Tomás Braulio, J

    2015-03-01

    Anesthesiology societies have issued various guidelines on preoperative fasting since 1990, not only to decrease the incidence of lung aspiration and anesthetic morbidity, but also to increase patient comfort prior to anesthesia. Some of these societies have been updating their guidelines, as such that, since 2010, we now have 2 evidence-based preoperative fasting guidelines available. In this article, an attempt is made to review these updated guidelines, as well as the current instructions for more controversial patients such as infants, the obese, and a particular type of ophthalmic surgery. Copyright © 2014 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Publicado por Elsevier España, S.L.U. All rights reserved.

  10. Fast computation of Krawtchouk moments

    Czech Academy of Sciences Publication Activity Database

    Honarvar Shakibaei Asli, B.; Flusser, Jan

    2014-01-01

    Roč. 288, č. 1 (2014), s. 73-86 ISSN 0020-0255 R&D Projects: GA ČR GAP103/11/1552 Institutional support: RVO:67985556 Keywords : Krawtchouk polynomial * Krawtchouk moment * Geometric moment * Impulse response * Fast computation * Digital filter Subject RIV: JD - Computer Applications, Robotics Impact factor: 4.038, year: 2014 http://library.utia.cas.cz/separaty/2014/ZOI/flusser-0432452.pdf

  11. Fast, low noise transimpedance preamplifier

    International Nuclear Information System (INIS)

    Parlakyan, L.K.

    1995-01-01

    A single-channel transimpedance preamplifier for fast dielectric detectors is described. The main specifications of the preamplifier are: rise time is 1,5 ns; gain is 3,5 mV/μ A (with two section- 210 mV/μ A); r.m.s input noise is 30 n A; power consumption is 22 m W. Depending on supply voltage, the parameters may vary in a wide range. 5 refs

  12. The fast slow TDPAC spectrometer

    International Nuclear Information System (INIS)

    Cekic, B.; Koicki, S.; Manasijevic, M.; Ivanovic, N.; Koteski, V.; Milosevic, Z.; Radisavljevic, I.; Cavor, J.; Novakovic, N.; Marjanovic, D.

    2001-01-01

    A 2-BaF 2 detector - fast slow time spectrometer for time differential perturbed angular correlations (TDPAC) experiments is described. This apparatus has been developed in the Group for Hyperfine Interactions in the Institute for Nuclear Sciences in VINCA. The excellent time resolution combined with high efficiency offered by these detectors enables one high counting rate performance and is operating in the wide temperature range 78-1200 K. (author)

  13. Fast superconducting magnetic field switch

    Science.gov (United States)

    Goren, Yehuda; Mahale, Narayan K.

    1996-01-01

    The superconducting magnetic switch or fast kicker magnet is employed with electron stream or a bunch of electrons to rapidly change the direction of flow of the electron stream or bunch of electrons. The apparatus employs a beam tube which is coated with a film of superconducting material. The tube is cooled to a temperature below the superconducting transition temperature and is subjected to a constant magnetic field which is produced by an external dc magnet. The magnetic field produced by the dc magnet is less than the critical field for the superconducting material, thus, creating a Meissner Effect condition. A controllable fast electromagnet is used to provide a magnetic field which supplements that of the dc magnet so that when the fast magnet is energized the combined magnetic field is now greater that the critical field and the superconducting material returns to its normal state allowing the magnetic field to penetrate the tube. This produces an internal field which effects the direction of motion and of the electron stream or electron bunch. The switch can also operate as a switching mechanism for charged particles.

  14. The instrumentation of fast reactor

    International Nuclear Information System (INIS)

    Endo, Akira

    2003-03-01

    The author has been engaged in the development of fast reactors over the last 30 years with both an involvement with the early technology development on the experimental breeder reactor Joyo, and latterly continuing this work on the prototype breeder reactor, Monju. In order to pass on this experience to younger engineers this paper is produced to outline this experience in the sincere hope that the information given will be utilised in future educational training material. The paper discusses the wide diversity on the associated instrument technology which the fast breeder reactor requires. The first chapter outlines the fast reactor system, followed by discussions on reactor instrumentation, measurement principles, temperature dependencies, and verification response characteristics from various viewpoints, are discussed in chapters two and three. The important issues of failed fuel location detection, and sodium leak detection from steam generators are discussed in chapters 4 and 5 respectively. Appended to this report is an explanation on the methods of measuring response characteristics on instrumentation systems using error analysis, random signal theory and measuring method of response characteristic by AR (autoregressive) model on which it appears is becoming an indispensable problem for persons involved with this technology in the future. (author)

  15. Fast reactors: the industrial perspective

    International Nuclear Information System (INIS)

    Vaughan, R.D.

    1986-01-01

    Industrial participation in the development of the fast reactor is reviewed, from the construction of PFR at Dounreay to the initial steps towards collaboration in Europe. The optimum design of the fast reactor has changed considerably from the days when it was needed urgently to forestall a shortage of uranium to today when uranium is abundant and cheap. The evolution of the reactor design over this period is described. Collaboration in Europe is shown to be the only answer to high development costs and the search for a reactor which will compete with thermal reactors in today's environment. The partner countries in this collaboration are all motivated differently, and this is leading to some delays in concluding the necessary agreements. The objective on the industrial front is now to participate in the two or three demonstration fast reactors that will be built in Europe during the remainder of the century leading, it is hoped, to a competitive reactor design by the year 2000. (author)

  16. ATLAS Fast Physics Monitoring: TADA

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00375930; The ATLAS collaboration; Elsing, Markus

    2017-01-01

    The ATLAS experiment at the LHC is recording data from proton-proton collisions with 13 TeV center-of-mass energy since spring 2015. The collaboration is using a fast physics monitoring framework (TADA) to automatically perform a broad range of fast searches for early signs of new physics and to monitor the data quality across the year with the full analysis level calibrations applied to the rapidly growing data.TADA is designed to provide fast feedback directly after the collected data has been fully calibrated and processed at the Tier-0, the CERN Data Center. The system can monitor a large range of physics channels, offline data quality and physics performance quantities nearly final analysis level object calibrations. TADA output is available on a website accessible by the whole collaboration that gets updated twice a day with the data from newly processed runs. Hints of potentially interesting physics signals or performance issues identified in this way are reported to be followed up by physics or combin...

  17. ATLAS fast physics monitoring: TADA

    Science.gov (United States)

    Sabato, G.; Elsing, M.; Gumpert, C.; Kamioka, S.; Moyse, E.; Nairz, A.; Eifert, T.; ATLAS Collaboration

    2017-10-01

    The ATLAS experiment at the LHC has been recording data from proton-proton collisions with 13 TeV center-of-mass energy since spring 2015. The collaboration is using a fast physics monitoring framework (TADA) to automatically perform a broad range of fast searches for early signs of new physics and to monitor the data quality across the year with the full analysis level calibrations applied to the rapidly growing data. TADA is designed to provide fast feedback directly after the collected data has been fully calibrated and processed at the Tier-0. The system can monitor a large range of physics channels, offline data quality and physics performance quantities. TADA output is available on a website accessible by the whole collaboration. It gets updated twice a day with the data from newly processed runs. Hints of potentially interesting physics signals or performance issues identified in this way are reported to be followed up by physics or combined performance groups. The note reports as well about the technical aspects of TADA: the software structure to obtain the input TAG files, the framework workflow and structure, the webpage and its implementation.

  18. ATLAS Fast Physics Monitoring: TADA

    CERN Document Server

    Elsing, Markus; The ATLAS collaboration; Sabato, Gabriele; Kamioka, Shusei; Nairz, Armin Michael; Moyse, Edward; Gumpert, Christian

    2016-01-01

    The ATLAS Experiment at the LHC is recording data from proton-proton collisions with 13 TeV center-of-mass energy since spring 2015. The collaboration is using a fast physics monitoring framework (TADA) to automatically perform a broad range of fast searches for early signs of new physics and to monitor the data quality across the year with the full analysis level calibrations applied to the rapidly growing data. TADA is designed to provide fast feedback directly after the collected data has been fully calibrated and processed at the Tier-0. The system can monitor a large range of physics channels, offline data quality and physics performance quantities nearly final analysis level object calibrations. TADA output is available on a website accessible by the whole collaboration that gets updated twice a day with the data from newly processed runs. Hints of potentially interesting physics signals or performance issues identified in this way are reported to be followed up by physics or combined performance groups...

  19. Fast superconducting magnetic field switch

    International Nuclear Information System (INIS)

    Goren, Y.; Mahale, N.K.

    1996-01-01

    The superconducting magnetic switch or fast kicker magnet is employed with electron stream or a bunch of electrons to rapidly change the direction of flow of the electron stream or bunch of electrons. The apparatus employs a beam tube which is coated with a film of superconducting material. The tube is cooled to a temperature below the superconducting transition temperature and is subjected to a constant magnetic field which is produced by an external dc magnet. The magnetic field produced by the dc magnet is less than the critical field for the superconducting material, thus, creating a Meissner Effect condition. A controllable fast electromagnet is used to provide a magnetic field which supplements that of the dc magnet so that when the fast magnet is energized the combined magnetic field is now greater that the critical field and the superconducting material returns to its normal state allowing the magnetic field to penetrate the tube. This produces an internal field which effects the direction of motion and of the electron stream or electron bunch. The switch can also operate as a switching mechanism for charged particles. 6 figs

  20. Fast Reactors and Nuclear Nonproliferation

    International Nuclear Information System (INIS)

    Avrorina, E.N.; Chebeskovb, A.N.

    2013-01-01

    Conclusion remarks: 1. Fast reactor start-up with U-Pu fuel: – dependent on thermal reactors, – no needs in U enrichment, – needs in SNF reprocessing, – Pu is a little suitable for NED, – practically impossible gun-type NED, – difficulties for implosion-type NED: necessary tests, advanced technologies, etc. – Pu in blankets is similar to WPu by isotopic composition, – Use of blanket for production isotopes (e.g. 233 U), – Combined reprocessing of SNF: altogether blanket and core, – Blanket elimination: decrease in Pu production – No pure Pu separation. 2. Fast reactor start-up with U fuel: - Needs in both U enrichment and SNF reprocessing, - Independent of thermal reactors, - Good Pu bred in the core let alone blankets, - NED of simple gun-type design, - Increase of needs in SWU, - Increased demands in U supply. 3. Fast reactors for export: - Uranium shortage, - To replace thermal reactors in future, - No blankets (depends on the country, though), - Fuel supply and SNF take back, - International centers for rendering services of NFC. Time has come to remove from FRs and their NFC the label unfairly identifying them as the most dangerous installations of nuclear power from the standpoint of being a proliferation problem

  1. A repeating fast radio burst.

    Science.gov (United States)

    Spitler, L G; Scholz, P; Hessels, J W T; Bogdanov, S; Brazier, A; Camilo, F; Chatterjee, S; Cordes, J M; Crawford, F; Deneva, J; Ferdman, R D; Freire, P C C; Kaspi, V M; Lazarus, P; Lynch, R; Madsen, E C; McLaughlin, M A; Patel, C; Ransom, S M; Seymour, A; Stairs, I H; Stappers, B W; van Leeuwen, J; Zhu, W W

    2016-03-10

    Fast radio bursts are millisecond-duration astronomical radio pulses of unknown physical origin that appear to come from extragalactic distances. Previous follow-up observations have failed to find additional bursts at the same dispersion measure (that is, the integrated column density of free electrons between source and telescope) and sky position as the original detections. The apparent non-repeating nature of these bursts has led to the suggestion that they originate in cataclysmic events. Here we report observations of ten additional bursts from the direction of the fast radio burst FRB 121102. These bursts have dispersion measures and sky positions consistent with the original burst. This unambiguously identifies FRB 121102 as repeating and demonstrates that its source survives the energetic events that cause the bursts. Additionally, the bursts from FRB 121102 show a wide range of spectral shapes that appear to be predominantly intrinsic to the source and which vary on timescales of minutes or less. Although there may be multiple physical origins for the population of fast radio bursts, these repeat bursts with high dispersion measure and variable spectra specifically seen from the direction of FRB 121102 support an origin in a young, highly magnetized, extragalactic neutron star.

  2. Astrid (fast breeder nuclear reactor)

    International Nuclear Information System (INIS)

    2014-01-01

    This document presents ASTRID (Advanced Sodium Technological Reactor for Industrial Demonstration), a French project of sodium-cooled fast breeder reactor, fourth generation reactor which should be fuelled by uranium 238 rather than uranium 235, and should therefore need less extracted natural uranium to produce electricity. The operation principle of fast breeder reactors is described. They notably directly consume plutonium, allow an easier radioactive waste management as they transform long life radioactive elements into shorter life elements by transmutation. The regeneration process is briefly described, and the various operation modes are evoked (iso-generator, sub-generator, and breeder). Some peculiarities of sodium-cooled reactors are outlined. The Astrid operation principle is described, its main design innovations outlined. Various challenges are discussed regarding safety of supply and waste processing, and the safety of future reactors. Major actors are indicated: CEA, Areva, EDF, SEIV Alcen, Toshiba, Rolls Royce, and Comex. Some key data are indicated: expected lifetime, expected availability rate, cost. The projected site is Marcoule and fast breeder reactors operated or under construction in the world are indicated. The document also proposes an overview of the background and evolution of reactors of 4. generation

  3. Medical radiography with fast neutrons

    International Nuclear Information System (INIS)

    Duehmke, E.

    1980-01-01

    Neutron radiography is important in medicine for two reasons. On the one hand, macroradiographical findings are different from X-ray findings, i.e. new information may be gained on the morphology of humans and animals. On the other hand, there is a direct practical application in the radiotherapy of malignant tumours if one considers the assessment of the growth of malignant processes. Fast neutrons are required for neutron radiographies of biological objects with a diameter of more than 2 cm. In addition sensitive, two-dimensional detectors must be used which are selective for fast neutrons. The book describes the optimisation and sensitisation of a detector using the example of cellulose nitrate foil for fast reactor neutrons. Images of human spinal chords with tumours proved by pathological and anatomical examinations give a better picture of the dimensions of the tumour than comparative X-ray pictures. For examinations of living patients, neutron radiography should be applied only in those tumour-bearing parts of the bodies in which radiation treatment is required for therapeutical purposes anyway. (orig./MG) [de

  4. The Fast-Casual Conundrum: Fast-Casual Restaurant Entrées Are Higher in Calories than Fast Food.

    Science.gov (United States)

    Schoffman, Danielle E; Davidson, Charis R; Hales, Sarah B; Crimarco, Anthony E; Dahl, Alicia A; Turner-McGrievy, Gabrielle M

    2016-10-01

    Frequently eating fast food has been associated with consuming a diet high in calories, and there is a public perception that fast-casual restaurants (eg, Chipotle) are healthier than traditional fast food (eg, McDonald's). However, research has not examined whether fast-food entrées and fast-casual entrées differ in calorie content. The purpose of this study was to determine whether the caloric content of entrées at fast-food restaurants differed from that found at fast-casual restaurants. This study was a cross-sectional analysis of secondary data. Calorie information from 2014 for lunch and dinner entrées for fast-food and fast-casual restaurants was downloaded from the MenuStat database. Mean calories per entrée between fast-food restaurants and fast-casual restaurants and the proportion of restaurant entrées that fell into different calorie ranges were assessed. A t test was conducted to test the hypothesis that there was no difference between the average calories per entrée at fast-food and fast-casual restaurants. To examine the difference in distribution of entrées in different calorie ranges between fast-food and fast-casual restaurants, χ(2) tests were used. There were 34 fast-food and 28 fast-casual restaurants included in the analysis (n=3,193 entrées). Fast-casual entrées had significantly more calories per entrée (760±301 kcal) than fast-food entrées (561±268; Prestaurants to determine whether the energy content or nutrient density of full meals (ie, entrées with sides and drinks) differs between fast-casual restaurants and fast-food restaurants. Calorie-conscious consumers should consider the calorie content of entrée items before purchase, regardless of restaurant type. Copyright © 2016 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

  5. Status of national programmes on fast reactors

    International Nuclear Information System (INIS)

    1994-04-01

    Based on the International Working Group on Fast reactors (IWGFR) members' request, the IAEA organized a special meeting on Fast Reactor Development and the Role of the IAEA in May 1993. The purpose of the meeting was to review and discuss the status and recent development, to present major changes in fast reactor programmes and to recommend future activities on fast reactors. The IWGFR took note that in some Member States large prototypes have been built or are under construction. However, some countries, due to their current budget constraints, have reduced the level of funding for research and development programmes on fast reactors. The IWGFR noted that in this situation the international exchange of information and cooperation on the development of fast reactors is highly desirable and stressed the importance of the IAEA's programme on fast reactors. These proceedings contain important and useful information on national programmes and new developments in sodium cooled fast reactors in Member States. Refs, figs and tabs

  6. Fleet Assistance and Support Team (FAST) Lab

    Data.gov (United States)

    Federal Laboratory Consortium — The FAST team was established by PMA-264 for introduction of multistatic ASW systems into the Fleet.FAST provides Air ASW mission planning, tactics/tactical sensor...

  7. Percentage of Fast-Track Receipts

    Data.gov (United States)

    Social Security Administration — The dataset provides the percentage of fast-track receipts by state during the reporting fiscal year. Fast-tracked cases consist of those cases identified as Quick...

  8. Gluconeogenesis and fasting in cerebral malaria

    NARCIS (Netherlands)

    van Thien, H.; Ackermans, M. T.; Weverling, G. J.; Dang Vinh, T.; Endert, E.; Kager, P. A.; Sauerwein, H. P.

    2004-01-01

    BACKGROUND: In healthy subjects after an overnight fast, glucose production is for approximately 50% derived from glycogenolysis. If the fast is prolonged, glucose production decreases due to a decline in glycogenolysis, while gluconeogenesis remains stable. In cerebral malaria, glucose production

  9. The Fast Simulation Chain for ATLAS

    CERN Document Server

    Basalaev, Artem; The ATLAS collaboration

    2016-01-01

    In order to generate the huge number of Monte Carlo events that will be required by the ATLAS experiment over the next several runs, a very fast simulation is critical. Fast detector simulation alone, however, is insufficient: with very high numbers of simultaneous proton-proton collisions expected in Run 3 and beyond, the digitization (detector response emulation) and event reconstruction time quickly become comparable to the time required for detector simulation. The ATLAS Fast Chain simulation has been developed to solve this problem. Modules are implemented for fast simulation, fast digitization, and fast track reconstruction. The application is sufficiently fast -- several orders of magnitude faster than the standard simulation -- that the simultaneous proton-proton collisions can be generated during the simulation job, so Pythia8 also runs concurrently with the rest of the algorithms. The Fast Chain has been built to be extremely modular and flexible, so that each sample can be custom-tailored to match ...

  10. The digital backend of FAST

    Science.gov (United States)

    Yu, Xinying; Zhang, Xia; Duan, Ran; li, di; Hao, Jie

    2015-08-01

    The receiver system is an important part of FAST (Five-hundred-meter Aperture Spherical Radio Telescope) and plays a key role in determining the performance of the telescope.This research covers three major aspects: establishment of system synchronization and timestamps, field-programmable gate array (FPGA)-based data transmission and analysis, and the rear receiver monitoring system. We intend to combine the use of GPS and a frequency standard instrument with network access to Unix timestamps to form actual timestamps. The data are stored with timestamps that contain integer and fractional seconds to be precise and headers, which are primarily intended to distinguish the data from each other.The data analysis procedures includes converting the timestamp information to real-time information, and merging the 8 channels’ data conversion results into frequency and energy data using corresponding conversion formulae. We must develop tailored monitoring software for the FAST receiver to customize the data format and perform data transmission. Signals on the front-end and back-end of the receiver can be monitored and controlled by adjusting the parameters on the software to increase the flexibility of the receiver.Most operations are performed on FPGA board, which can be shown from the figure, including the analog-to-digital conversion (ADC), fast Fourier transform (FFT), and pulse per second (1PPS) and Unix timestamp access operations.When analog data arrive, we initialize two ADCs at a sampling rate of 3Gsps, following by 8-channel FFT parallel processing.In collaboration with the Institute of Automation, we have developed a custom FPGA board which we call "FDB"("FAST Digital Backend"). The board is integrated with two Virtex-6 and one Virtex-5 high-speed Xilinx chips. The main function of the two Virtex-6 devices is to run the FFT and PFB programs, whereas the main function of Virtex-5 is configuration of the board.This research is indispensable for realizing the

  11. Fast Weight Long Short-Term Memory

    OpenAIRE

    Keller, T. Anderson; Sridhar, Sharath Nittur; Wang, Xin

    2018-01-01

    Associative memory using fast weights is a short-term memory mechanism that substantially improves the memory capacity and time scale of recurrent neural networks (RNNs). As recent studies introduced fast weights only to regular RNNs, it is unknown whether fast weight memory is beneficial to gated RNNs. In this work, we report a significant synergy between long short-term memory (LSTM) networks and fast weight associative memories. We show that this combination, in learning associative retrie...

  12. Fast Foods, Organic Foods, Fad Diets

    Science.gov (United States)

    There is no standard definition of fast food. Generally, fast food is eaten without cutlery, and fast-food restaurants have no wait staff. Failure to have a standardized definition makes it difficult to compare studies. Foods available outside the home tend to be high in energy and fat compared w...

  13. Introduction of the experimental fast reactor JOYO

    International Nuclear Information System (INIS)

    Matsuba, Ken-ichi; Kawahara, Hirotaka; Aoyama, Takafumi

    2006-01-01

    The experimental fast reactor JOYO at O-arai Engineering Center of Japan Nuclear Cycle Development Institute is the first liquid metal cooled fast reactor in Japan. This paper describes the plant outline, experiences on the fast reactor technology and test results accumulated through twenty eight years successful operation of JOYO. (author)

  14. Comparison of Fast-Food and Non-Fast-Food Children's Menu Items

    Science.gov (United States)

    Serrano, Elena L.; Jedda, Virginia B.

    2009-01-01

    Objective: Compare the macronutrient content of children's meals sold by fast-food restaurants (FFR) and non-fast-food restaurants (NFF). Design: All restaurants within the designated city limits were surveyed. Non-fast-food children's meals were purchased, weighed, and analyzed using nutrition software. All fast-food children's meals were…

  15. Experimental and numerical studies of the fast ions confined in TFR 600 during fast neutrals injection

    International Nuclear Information System (INIS)

    Gagey, B.

    1980-08-01

    We present a comparison between experimental fast neutrals spectrum measured with a very simple electrostatic analyzer which has been absolutely calibrated, spectrum obtained during fast neutrals injection in TFR 600, and numerical fast neutrals spectrum obtained from a modified Monte-Carlo calculation code. This comparison allows us to draw important conclusions on the fast ions behavior in the plasma

  16. ATLAS FTK Fast Track Trigger

    CERN Document Server

    Iizawa, T; The ATLAS collaboration

    2014-01-01

    The Fast TracKer (FTK) will perform global track reconstruction after each Level-1 trigger accept signal to enable the software-based higher level trigger to have early access to tracking information. FTK is a dedicated processor based on a mixture of advanced technologies. Modern, powerful Field Programmable Gate Arrays (FPGAs) form an important part of the system architecture, and the large level of computing power required for pattern recognition is provided by incorporating standard-cell ASICs named Associative Memory (AM). Motivation and the architecture of the FTK system will be presented, and the status of hardware and simulation will be following.

  17. Fast feedback for linear colliders

    International Nuclear Information System (INIS)

    Hendrickson, L.; Adolphsen, C.; Allison, S.; Gromme, T.; Grossberg, P.; Himel, T.; Krauter, K.; MacKenzie, R.; Minty, M.; Sass, R.

    1995-01-01

    A fast feedback system provides beam stabilization for the SLC. As the SLC is in some sense a prototype for future linear colliders, this system may be a prototype for future feedbacks. The SLC provides a good base of experience for feedback requirements and capabilities as well as a testing ground for performance characteristics. The feedback system controls a wide variety of machine parameters throughout the SLC and associated experiments, including regulation of beam position, angle, energy, intensity and timing parameters. The design and applications of the system are described, in addition to results of recent performance studies

  18. Fast transfer of shared data

    International Nuclear Information System (INIS)

    Timmer, C.; Abbott, D.J.; Heyes, W.G.; Jostizembski, E.; MacLeod, R.W.; Wolin, E.

    2000-01-01

    The Event Transfer system enables its users to produce events (data) and share them with other users by utilizing shared memory on either Solaris or Linux-based computers. Its design emphasizes speed, reliability, ease of use, and recoverability from crashes. In addition to fast local operation, the ET system allows network transfer of events. Using multi-threaded code based on POSIX threades and mutexes, a successful implementation was developed which allowed passing events over 500 kHz on a 4 cpu Sun workstation and 150 kHz on a dual cpu PC

  19. PUC fast track nips returns

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    In the first of what it says will be annual cost-of-capital proceedings to set returns on equity and rates of return on rate base for electric utilities, the California Public Utilities Commission (PUC) lowered from 1989 levels the 1990 returns on common equity (ROE) and rates of return (ROR) for the state's four major investor-owned electric utilities. Under this fast-track procedure, by May 8 of every year, utilities will have to file an application for rate adjustments that reflect their projected costs of capital for the following year

  20. Fast global sequence alignment technique

    KAUST Repository

    Bonny, Mohamed Talal

    2011-11-01

    Bioinformatics database is growing exponentially in size. Processing these large amount of data may take hours of time even if super computers are used. One of the most important processing tool in Bioinformatics is sequence alignment. We introduce fast alignment algorithm, called \\'Alignment By Scanning\\' (ABS), to provide an approximate alignment of two DNA sequences. We compare our algorithm with the wellknown sequence alignment algorithms, the \\'GAP\\' (which is heuristic) and the \\'Needleman-Wunsch\\' (which is optimal). The proposed algorithm achieves up to 51% enhancement in alignment score when it is compared with the GAP Algorithm. The evaluations are conducted using different lengths of DNA sequences. © 2011 IEEE.

  1. Fast-acting valve actuator

    Science.gov (United States)

    Cho, Nakwon

    1980-01-01

    A fast-acting valve actuator utilizes a spring driven pneumatically loaded piston to drive a valve gate. Rapid exhaust of pressurized gas from the pneumatically loaded side of the piston facilitates an extremely rapid piston stroke. A flexible selector diaphragm opens and closes an exhaust port in response to pressure differentials created by energizing and de-energizing a solenoid which controls the pneumatic input to the actuator as well as selectively providing a venting action to one side of the selector diaphragm.

  2. The integral fast reactor concept

    International Nuclear Information System (INIS)

    Chang, Yoon I.; Marchaterre, J.F.

    1987-01-01

    The Integral Fast Reactor (IFR) is an innovative liquid metal reactor concept being developed at Argonne National Laboratory. It seeks to specifically exploit the inherent properties of liquid metal cooling and metallic fuel in a way that leads to substantial improvements in the characteristics of the complete reactor system. The IFR concept consists of four technical features: (1) liquid sodium cooling, (2) pool-type reactor configuration, (3) metallic fuel, and (4) an integral fuel cycle, based on pyrometallurgical processing and injection-cast fuel fabrication, with the fuel cycle facility collocated with the reactor, if so desired. This paper gives a review of the IFR concept

  3. Fast processor for dilepton triggers

    International Nuclear Information System (INIS)

    Katsanevas, S.; Kostarakis, P.; Baltrusaitis, R.

    1983-01-01

    We describe a fast trigger processor, developed for and used in Fermilab experiment E-537, for selecting high-mass dimuon events produced by negative pions and anti-protons. The processor finds candidate tracks by matching hit information received from drift chambers and scintillation counters, and determines their momenta. Invariant masses are calculated for all possible pairs of tracks and an event is accepted if any invariant mass is greater than some preselectable minimum mass. The whole process, accomplished within 5 to 10 microseconds, achieves up to a ten-fold reduction in trigger rate

  4. Electrochemistry in fast reactor technology

    International Nuclear Information System (INIS)

    Mathews, C.K.

    1987-01-01

    Electrochemistry plays a significant role in the production, characterisation or behaviour of the fuel, the coolant and structural materials used in fast reactor systems. The role of electrochemistry in sodium production, in the fuel cycle, in the development of electrochemical meters used for the on-line monitoring of the various impurities at sub ppm levels and in the recovery of plutonium and uranium are discussed. The advantage of voltammmetric techniques in the analysis of impurities and the application of electrochemical meters have been investigated. (author). 5 figs., 15 refs

  5. Concept and canons of fasting in Ayurveda

    Directory of Open Access Journals (Sweden)

    H Shripathi Adiga

    2013-03-01

    Full Text Available Ayurveda, manoeuvres mankind to head a healthy life in order to pursue four-fold bliss. With a view to combat physical and mental annoyances, classics have explicated two-fold therapeutic modalities; langhana/depletion and brihmana/nourishing. Upavasa /fasting is one among ten depletion therapies explained. It is envisioned at all three levels of Ayurvedic therapies- rational/objectively planned, psychological, and spiritual. Fasting is reckoned to be refraining from all forms of food intake for a given period, under supervision of a qualified physician. Acharya Charaka advocates fasting in diseases of milder intensity, in those due to aama (metabolic toxin, after purificatory procedures. Fasting person should avoid beautifying oneself, day sleep, sexual acts, and feasting prior and ulterior to fasting. Fasting is contraindicated in very young, elderly, emaciated, pregnant lady, and shortly after strenuous exercise. The principle avers that fasting kindles metabolic/digestive fire which, in absence of food, brings about paachana of vitiated doshas, thereby riposting health. Sound fasting ensues proper elimination of excretory wastes, clear belch, sweat, and taste for food. Benefits of fasting include lucidity of sense organs, lightness of body and mind, control of diseases, and enthusiasm. Yoga Shastra describes fasting with respect to three levels of food: physical, impressions, and associations and a means to unite three bodies: astral, physical, and causal. Ayurveda thus advocates fasting depending upon the dosha, agni, vaya, kala, and bala of the individual, as a preventive as well as therapeutic modality.

  6. The Fast Simulation Chain for ATLAS

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00399337; The ATLAS collaboration; Marshall, Zach

    2017-01-01

    In order to generate the huge number of Monte Carlo events that will be required by the ATLAS experiment over the next several runs, a very fast simulation is critical. Fast detector simulation alone, however, is insufficient: with very high numbers of simultaneous proton-proton collisions expected in Run 3 and beyond, the digitization (detector response emulation) and event reconstruction time quickly become comparable to the time required for detector simulation. The ATLAS Fast Chain simulation has been developed to solve this problem. Modules are implemented for fast simulation, fast digitization, and fast track reconstruction. The application is sufficiently fast—several orders of magnitude faster than the standard simulation—that the simultaneous proton-proton collisions can be generated during the simulation job, so Pythia8 also runs concurrently with the rest of the algorithms. The Fast Chain has been built to be extremely modular and flexible, so that each sample can be custom-tailored to match th...

  7. Neighborhood fast food restaurants and fast food consumption: A national study

    OpenAIRE

    Richardson, Andrea S; Boone-Heinonen, Janne; Popkin, Barry M; Gordon-Larsen, Penny

    2011-01-01

    Abstract Background Recent studies suggest that neighborhood fast food restaurant availability is related to greater obesity, yet few studies have investigated whether neighborhood fast food restaurant availability promotes fast food consumption. Our aim was to estimate the effect of neighborhood fast food availability on frequency of fast food consumption in a national sample of young adults, a population at high risk for obesity. Methods We used national data from U.S. young adults enrolled...

  8. Fast reactor core monitoring device

    International Nuclear Information System (INIS)

    Sanda, Toshio; Inoue, Kotaro; Azekura, Kazuo.

    1982-01-01

    Purpose: To enable the rapid and accurate on-line identification of the state of a fast reactor core by effectively utilizing the measured data on the temperature and flow rate of the coolant. Constitution: The spacial power distribution and average assembly power are quickly calculated using an approximate calculating method, the measured values and the calculated values of the inlet and outlet temperature difference, flow rate and coolant physical values of an assembly are combined and are individually obtained, the most definite respective values and their errors are obtained by a least square method utilizing a formula of the relation between these values, and the power distribution and the temperature distribution of a reactor core are estimated in this manner. Accordingly, even when the measuring accuracy and the calculating accuracy are equal as in a fast reactor, the power distribution and the temperature distribution can be accurately estimated on-line at a high speed in a nuclear reactor, information required for the operator is provided, and the reactor can thus be safely and efficiently operated. (Yoshihara, H.)

  9. Fast breeder fuel element development

    International Nuclear Information System (INIS)

    Marth, W.; Muehling, G.

    1983-08-01

    This report is a compilation of the papers which have been presented during a seminar ''Fast Breeder Fuel Element Development'' held on November 15/16, 1982 at KfK. The papers give a survey of the status, of the obtained results and of the necessary work, which still has to be done in the frame of various development programmes for fast breeder fuel elements. In detail the following items were covered by the presentations: - the requirements and boundary conditions for the design of fuel pins and elements both for the reference concept of the SNR 300 core and for the large, commercial breeder type of the future (presentation 1,2 and 6); - the fabrication, properties and characterization of various mixed oxide fuel types (presentations 3,4 and 5); - the operational fuel pin behaviour, limits of different design concepts and possible mechanism for fuel pin failures (presentations (7 and 8); - the situation of cladding- and wrapper materials development especially with respect to the high burn-up values of commercial reactors (presentations 9 and 10); - the results of the irradiation experiments performed under steady-state and non-stationary operational conditions and with failed fuel pins (presentations 11, 12, 13 and 14). (orig./RW) [de

  10. Computerized tomography using fast neutrons

    International Nuclear Information System (INIS)

    Maier-Schuler, P.

    1992-03-01

    The equipment is transportable and can be used at different neutron sources. CT-images are presented showing that it is possible to get good results by using CT with fast neutrons in non destructive testing. Small defects with high contrasts can be detected as well as larger defects with small differences in material density. Since the neutrons interact with the nuclei and not with the electron density the CT-images contain different information compared with X-ray or γ images. As neutron sources always emit γ-radiation too, this radiation can be detected simultaneously with the neutrons. Therefore one can get a γ CT-image along with the neutron image. For the examination of small samples or objects containing materials with great differences in the linear attenuation coefficients like Al and H 2 thermal neutrons have been used for CT-measurements too. A spatial resolution and a density resolution of 0.1 mm and about 5% respectively could be achieved in the CT-images with fast neutrons and 0.04 mm with thermal neutrons. (orig./HP) [de

  11. Fast calorimeter simulation in LHCb

    CERN Multimedia

    CERN. Geneva

    2018-01-01

    Fast calorimeter simulation in LHCb In HEP experiments CPU resources required by MC simulations are constantly growing and become a very large fraction of the total computing power (greater than 75%). At the same time the pace of performance improvements from technology is slowing down, so the only solution is a more efficient use of resources. Efforts are ongoing in the LHC experiments to provide multiple options for simulating events in a faster way when higher statistics is needed. A key of the success for this strategy is the possibility of enabling fast simulation options in a common framework with minimal action by the final user. In this talk we will describe the solution adopted in Gauss, the LHCb simulation software framework, to selectively exclude particles from being simulated by the Geant4 toolkit and to insert the corresponding hits generated in a faster way. The approach, integrated within the Geant4 toolkit, has been applied to the LHCb calorimeter but it could also be used for other subdetec...

  12. The 'SURA' fast reactor program

    International Nuclear Information System (INIS)

    Anon.

    1979-01-01

    The Commissariat a l'Energie Atomique's SURA program on fast reactor safety consists of two specific testing programs on fastbreeder reactor safety: the Cabri and Scarabee programs. Both Cabri and Scarabee are examples of multinational research collaboration. The CEA and the Karlsruhe Nuclear Research Center are each covering half of the construction costs. Britain, the US and Japan are also due to participate in these experiments. The aim of the programs is to examine the behaviour of fuel in sodium cooled fast reactors. The Cabri program consists of setting off a reactivity accident in a power reactor core which is cooled with liquid sodium, such an accident occurring after a sharp increase in reactivity or as a result of the pump suddenly breaking down without there at the same time being any fall in the control rods. In 1967 the Commissariat a l'Energie Atomique started its Scarabee research program which is trying to analyse the sort of things that can go wrong with fuel cooling systems and what the consequences can be [fr

  13. ATLAS FTK: Fast Track Trigger

    CERN Document Server

    Volpi, Guido; The ATLAS collaboration

    2015-01-01

    An overview of the ATLAS Fast Tracker processor is presented, reporting the design of the system, its expected performance, and the integration status. The next LHC runs, with a significant increase in instantaneous luminosity, will provide a big challenge to the trigger and data acquisition systems of all the experiments. An intensive use of the tracking information at the trigger level will be important to keep high efficiency in interesting events, despite the increase in multiple p-p collisions per bunch crossing (pile-up). In order to increase the use of tracks within the High Level Trigger (HLT), the ATLAS experiment planned the installation of an hardware processor dedicated to tracking: the Fast TracKer (FTK) processor. The FTK is designed to perform full scan track reconstruction at every Level-1 accept. To achieve this goal, the FTK uses a fully parallel architecture, with algorithms designed to exploit the computing power of custom VLSI chips, the Associative Memory, as well as modern FPGAs. The FT...

  14. Fast electron transport in shaped solid targets

    International Nuclear Information System (INIS)

    Anle Lei; Cao, L.H.; He, X.T.; Zhang, W.Y.; Tanaka, K.A.; Kodama, R.; Mima, K.; Nakamura, T.; Normatsu, T.; Yu, W.

    2010-01-01

    Complete text of publication follows. The scheme of fast ignition fusion energy relies on the ultra-intense ultra-short (UIUS) laser energy transport into the compressed core plasma. One solution is to insert a hollow cone in the fuel shell to block the UIUS laser from the coronal plasma, thus allowing it to reach the core plasma. The cone not only can guide the UIUS laser to its tip, but can play important roles in the specific cone-in-shell target designed for FI. It was found in a PIC simulation that the cone can guide the fast electrons generated at the inner wall to propagate along the wall surface toward its tip, which would increase the energy density at the tip and might enhance the heating of the core plasma. Surface guiding of fast electrons with planar foil targets has been demonstrated experimentally. However, the guided fast electrons will mix the electrons generated ahead by the laser light with a planar target, and hence one cannot experimentally quantitatively validate the guide of the fast electrons. We investigate the cone guiding of fast electrons with an inverse cone target. We found a novel surface current of fast electrons propagating along the cone wall. The fast electrons generated at the planar outer tip of the inverse cone are guided and confined to propagate along the inverse cone wall to form a surface current by induced transient electric and magnetic fields associated with the current itself. Once departing from the source at the outer tip, this surface current of fast electrons is 'clean', neither experiencing the interacting laser light nor mixing fast electrons ahead, unlike those in cone or planar targets. This surface current in the inverse cone may explicitly give the capability of the guide of fast electron energy by the cone wall. The guiding and confinement of fast electrons is of important for fast ignition in inertial confinement fusion and several applications in high energy density science.

  15. Intermittent Fasting Promotes Fat Loss With Lean Mass Retention, Increased Hypothalamic Norepinephrine Content, and Increased Neuropeptide Y Gene Expression in Diet-Induced Obese Male Mice.

    Science.gov (United States)

    Gotthardt, Juliet D; Verpeut, Jessica L; Yeomans, Bryn L; Yang, Jennifer A; Yasrebi, Ali; Roepke, Troy A; Bello, Nicholas T

    2016-02-01

    Clinical studies indicate alternate-day, intermittent fasting (IMF) protocols result in meaningful weight loss in obese individuals. To further understand the mechanisms sustaining weight loss by IMF, we investigated the metabolic and neural alterations of IMF in obese mice. Male C57/BL6 mice were fed a high-fat diet (HFD; 45% fat) ad libitum for 8 weeks to promote an obese phenotype. Mice were divided into four groups and either maintained on ad libitum HFD, received alternate-day access to HFD (IMF-HFD), and switched to ad libitum low-fat diet (LFD; 10% fat) or received IMF of LFD (IMF-LFD). After 4 weeks, IMF-HFD (∼13%) and IMF-LFD (∼18%) had significantly lower body weights than the HFD. Body fat was also lower (∼40%-52%) in all diet interventions. Lean mass was increased in the IMF-LFD (∼12%-13%) compared with the HFD and IMF-HFD groups. Oral glucose tolerance area under the curve was lower in the IMF-HFD (∼50%), whereas the insulin tolerance area under the curve was reduced in all diet interventions (∼22%-42%). HPLC measurements of hypothalamic tissue homogenates indicated higher (∼55%-60%) norepinephrine (NE) content in the anterior regions of the medial hypothalamus of IMF compared with the ad libitum-fed groups, whereas NE content was higher (∼19%-32%) in posterior regions in the IMF-LFD group only. Relative gene expression of Npy in the arcuate nucleus was increased (∼65%-75%) in IMF groups. Our novel findings indicate that intermittent fasting produces alterations in hypothalamic NE and neuropeptide Y, suggesting the counterregulatory processes of short-term weight loss are associated with an IMF dietary strategy.

  16. Seminar | Development of a PET Cyclotron Based Irradiation Setup for Proton Radiobiology | 25 June

    CERN Multimedia

    2015-01-01

    Sharif Hasan Mahmoud Ghithan, a Palestinian postdoctoral researcher at the Laboratory of Instrumentation and Experimental Particle Physics (Portugal), will discuss the development of an out-of-yoke irradiation setup using the proton beam from a cyclotron that ordinarily produces radioisotopes for Positron Emission Tomography (PET). The speaker will also discuss possible future use of the results of this research for CERN’s new LEIR biomedical facility. The seminar will be proposed in the framework of a meeting of the CERN Medical Applications Study Group.   25 June, 2 p.m. to 3 p.m. Room 13-2-005 ABSTRACT: In this new irradiation setup, the current from a 20 mm thick aluminum transmission foil is read out by homemade transimpedance electronics, providing online dose information. The main monitoring variables, delivered in real-time, include beam current, integrated charge and dose rate. Hence the dose and integrated current delivered at a given instant to an experimental setu...

  17. Cyclotron-based nuclear science. Progress report, April 1, 1979-March 31, 1980

    Energy Technology Data Exchange (ETDEWEB)

    1980-06-01

    Research at the cyclotron institute is summarized. These major areas are covered: nuclear structure; nuclear reactions and scattering; polarization studies; interdisciplinary nuclear science; instrumentation and systems development; and publications. (GHT)

  18. Cyclotron based nuclear science: Progress report, April 1, 1986-March 31, 1987

    International Nuclear Information System (INIS)

    1987-08-01

    This report contains descriptions of research programs at the Institute, progress on construction of the K500 cyclotron, and descriptions of new experimental devices being built to take advantage of new beams that will be available. Several milestones were reached in construction of the new cyclotron during the period. In early summer, 1986, the magnet was completed with all trim coils and shimming iron in place. During July and August, the final field maps were made, which will be used for calculations of run parameters. In the spring, one rf amplifier was completed and tested over the full frequency and power range. Also in the spring, the computer control system successfully operated positioning controls and trim coil power supplies. Final assembly of the rf system including the dees, resonators and other 2 rf amplifiers is now underway. Initial attempts at getting beam are expected in September. The design of the ECR source was completed in the fall. A beam line configuration has been designed for the K500 cyclotron which will result initially in 3 lines, with a fourth to be added in 1988. With the eminent completion of the K500, there has been considerable instrumentation development. A 4π neutron calorimeter is under construction for heavy ion reaction studies, construction is beginning on a proton spectrometer for studies of Gamow-Teller matrix elements with the (d, 2 He) reaction, and several detector systems are being developed. During the year, the 88 inch cyclotron operated 4845 hours for research and beam development. Research programs in nuclear science scheduled 57% of the time. Atomic physics programs used 19% of the time, and a program in trace analysis scheduled 6%. An industrial testing laboratory used 18 hours. The remainder of the time was used for beam development, primarily for increasing the energy and/or intensity of heavy ion beams

  19. SPES: A new cyclotron-based facility for research and applications with high-intensity beams

    Science.gov (United States)

    Maggiore, M.; Campo, D.; Antonini, P.; Lombardi, A.; Manzolaro, M.; Andrighetto, A.; Monetti, A.; Scarpa, D.; Esposito, J.; Silvestrin, L.

    2017-06-01

    In 2016, Laboratori Nazionali di Legnaro (Italy) started the commissioning of a new accelerator facility based on a high-power cyclotron able to deliver proton beams up to 70 MeV of energy and 700 μA current. Such a machine is the core of the Selective Production of Exotic Species (SPES) project whose main goal is to provide exotics beam for nuclear and astrophysics research and to deliver high-intensity proton beams for medical applications and neutrons generator.

  20. [Cyclotron based nuclear science]. Progress in research, April 1, 1992--March 31, 1993

    Energy Technology Data Exchange (ETDEWEB)

    1993-07-01

    The period 1 April 1992--31 March 1993 saw the initial runs of three new spectrometers, which constitute a major portion of the new detection capabilities developed for this facility. These devices are the Proton Spectrometer (PSP) (data from which are shown on the cover of this document), the Mass Achroniat Recoil Mass Spectrometer (MARS), and the Multipole Dipole Multipole (MDM) Particle Spectrometer. The ECR-K500 cyclotron combination operated 5,849 hours. The beam was on target 39% of this time. Studies of nuclear dynamics and nuclear thermodynamics using the neutron ball have come to fruition. A critical re-evaluation of the available data on the giant monopole resonance indicated that the incompressibility is not specified to a range smaller than 200--350 MeV by those data. New systematic experiments using the MDM spectrometer are now underway. The MEGA collaboration obtained the first data on the {mu} {yields} e{gamma} decay rate and determination of the Michel parameter in normal {mu} decay. Experiments appear to confirm the existence of monoenergetic pair peaks even for relatively low Z{sub projectile} -- Z{sub target} combinations. Studies of the ({alpha},2{alpha}) knockout reaction indicate that this reaction may prove to be a valuable tool for determination of reaction rates of astrophysical interest. Theoretical work reported in this document ranges from nuclear structure calculations using the IBM-2 model to calculations of kaon production and the in-medium properties of the rho and phi mesons. Nuclear dynamics and exotic shapes and fragmentation modes of hot nuclei are also addressed. New measurements of x-ray emission from highly ionized ions, of molecular dissociation and of surface interactions are reported. The research is presented in nearly 50 brief summaries usually including data and references.

  1. Cyclotron based nuclear science: Progress report, April 1, 1987-March 31, 1988

    International Nuclear Information System (INIS)

    1988-08-01

    This report discusses experiment run on the K500 cyclotron and 88 in cyclotron at Texas AandM University. The main topics of these experiments are: Heavy ion reactions; Nuclear structure and fundamental interactions; Atomic and material science; Nuclear theory; and Superconducting cyclotron and instrumentation

  2. Single bunch fast longitudinal instability

    International Nuclear Information System (INIS)

    Wang, J.M.; Pellegrini, C.

    1979-01-01

    Single bunch longitudinal instability producing an increase of the bunch area have been observed in proton synchrotron and storage rings. Signals at microwave frequencies are observed during the bunch blow-up and because of this the effect has been called the microwave instability. A similar increase in bunch area is observed also in electron storage rings, where it is usually referred to as the bunch lengthening effect. This paper is an attempt to obtain a more general theory of this effect. Here we describe the model used and the method of calculation, together with some general results. More detailed results will be given in another paper. The main result is the derivation of a condition for the existence of a fast longitudinal bunch blow-up. This condition is a generalized threshold formula, showing explicitly the dependence on the bunch energy spread and length. This condition is qualitatively in agreement with Boussard's suggestion

  3. Fast High-Quality Noise

    DEFF Research Database (Denmark)

    Frisvad, Jeppe Revall; Wyvill, Geoff

    2007-01-01

    At the moment the noise functions available in a graphics programmer's toolbox are either slow to compute or they involve grid-line artifacts making them of lower quality. In this paper we present a real-time noise computation with no grid-line artifacts or other regularity problems. In other words......, we put a new tool in the box that computes fast high-quality noise. In addition to being free of artifacts, the noise we present does not rely on tabulated data (everything is computed on the fly) and it is easy to adjust quality vs. quantity for the noise. The noise is based on point rendering (like...... spot noise), but it extends to more than two dimensions. The fact that it is based on point rendering makes art direction of the noise much easier....

  4. Integral fast reactor safety features

    International Nuclear Information System (INIS)

    Cahalan, J.E.; Kramer, J.M.; Marchaterre, J.F.; Mueller, C.J.; Pedersen, D.R.; Sevy, R.H.; Wade, D.C.; Wei, T.Y.C.

    1988-01-01

    The Integral Fast Reactor (IFR) is an advanced liquid-metal-cooled reactor concept being developed at Argonne National Laboratory. The two major goals of the IFR development effort are improved economics and enhanced safety. In addition to liquid metal cooling, the principal design features that distinguish the IFR are: (1) a pool-type primary system, (2) an advanced ternary alloy metallic fuel, and (3) an integral fuel cycle with on-site fuel reprocessing and fabrication. This paper focuses on the technical aspects of the improved safety margins available in the IFR concept. This increased level of safety is made possible by (1) the liquid metal (sodium) coolant and pool-type primary system layout, which together facilitate passive decay heat removal, and (2) a sodium-bonded metallic fuel pin design with thermal and neutronic properties that provide passive core responses which control and mitigate the consequences of reactor accidents

  5. Fast thermal transients on valve

    International Nuclear Information System (INIS)

    Ferjancic, M.; Stok, B.; Halilovic, M.; Koc, P.; Mole, N.; Otrin, Z.; Kotar, A.

    2007-01-01

    One of the regulatory body methods to supervise nuclear safety of a nuclear power plant is a review of plant modifications and evaluation of their impact on plant operating experience. The Slovenian Nuclear Safety Administration (SNSA) licensed in April 2003 the use of leak-before-break (LBB) methodology in the Krsko NPP for the primary loop including surge line and connecting pipelines with minimal diameter of 6 inch. The SNSA decision based also on fracture mechanics analyses that include direct pipe failure mechanisms such as water hammer, creep damage, erosion and corrosion, fatigue and environmental conditions over the entire life of the plant. The evaluation of the operating transients pointed out, that presumed loadings, used for the LBB analysis, did not incorporate all the fast thermal transients data. For that purpose the SNSA requested Faculty of Mechanical Engineering (FS) in Ljubljana to perform additional analyses. The results of the analysis shall confirm the validity of the LBB analysis. (author)

  6. Decoherence recuperating fast environmental dynamics

    International Nuclear Information System (INIS)

    Cetinbas, Murat

    2010-01-01

    We examine the exact internal decoherence dynamics of a qubit in an isolated Josephson charge-qubit quantum computer in the presence of one- and two-body static internal imperfections. By help of open system dynamics quantifiers, i.e. purity, fidelity, covariance and Loschmidt echo, we distinguish between non-unitary and unitary components of internal decoherence dynamics and show that the non-unitary component consists of two processes: system-environment entanglement and incoherence. Our results indicate that the incoherence process is the major source of internal decoherence rather than system-environment entanglement. We find that strong one-body intra-environmental interactions, which generate fast environmental dynamics, result in a rapid suppression of decoherence induced by both system-environment entanglement and incoherence processes. We explain the mechanisms of suppression of decoherence for these two processes and discuss our results.

  7. First results on fast baking

    Energy Technology Data Exchange (ETDEWEB)

    Visentin, B. [CEA-Saclay, DSM/DAPNIA/SACM - 91191 Gif/Yvette Cedex (France)]. E-mail: bvisentin@cea.fr; Gasser, Y. [CEA-Saclay, DSM/DAPNIA/SACM - 91191 Gif/Yvette Cedex (France); Charrier, J.P. [CEA-Saclay, DSM/DAPNIA/SACM - 91191 Gif/Yvette Cedex (France)

    2006-07-15

    High gradient performances of bulk niobium cavities go through a low-temperature baking during one or two days, the temperature parameter is adjusted in a narrow tuning range around 110 or 120deg, C. With such treatment, the intrinsic quality factor Q{sub 0} is improved at high fields. Assuming the oxygen diffusion is involved in this phenomenon, we have developed the 'fast baking' (145deg, C/3h) as an alternative method. Similar results have been achieved with this method compared to standard baking. Consequently, for the first time, a link between oxygen diffusion and high field Q-slope has been demonstrated. Furthermore, this method open the way to a simpler and better baking procedure for the large-scale cavity production due to:*time reduction and *possibility to combine baking and drying during cavity preparation.

  8. Fast determination of plasma parameters

    International Nuclear Information System (INIS)

    Wijnands, T.J.; Parlange, F.; Joffrin, E.

    1995-01-01

    Fast analysis of diagnostic signals of a tokamak discharge is demonstrated by using 4 fundamentally different techniques. A comparison between Function Parametrization (FP), Canonical Correlation Analysis (CCA) and a particular Neural Network (NN) configuration known as the Multi Layer Perceptron (MLP) is carried out, thereby taking a unique linear model based on a Singular Value Decomposition (SVD) as a reference. The various techniques provide all functional representations of characteristic plasma parameters in terms of the values of the measurements and are based on an analysis of a large, experimentally achieved database. A brief mathematical description of the various techniques is given, followed by two particular applications to Tore Supra diagnostic data. The first problem is concerned with the identification of the plasma boundary parameters using the poloidal field and differential poloidal flux measurements. A second application involves the interpretation of line integrated data from the multichannel interfero-polarimeter to obtain the central value of the safety factor. (author) 4 refs.; 3 figs

  9. First results on fast baking

    International Nuclear Information System (INIS)

    Visentin, B.; Gasser, Y.; Charrier, J.P.

    2006-01-01

    High gradient performances of bulk niobium cavities go through a low-temperature baking during one or two days, the temperature parameter is adjusted in a narrow tuning range around 110 or 120deg, C. With such treatment, the intrinsic quality factor Q 0 is improved at high fields. Assuming the oxygen diffusion is involved in this phenomenon, we have developed the 'fast baking' (145deg, C/3h) as an alternative method. Similar results have been achieved with this method compared to standard baking. Consequently, for the first time, a link between oxygen diffusion and high field Q-slope has been demonstrated. Furthermore, this method open the way to a simpler and better baking procedure for the large-scale cavity production due to:*time reduction and *possibility to combine baking and drying during cavity preparation

  10. Fast algorithm for Morphological Filters

    International Nuclear Information System (INIS)

    Lou Shan; Jiang Xiangqian; Scott, Paul J

    2011-01-01

    In surface metrology, morphological filters, which evolved from the envelope filtering system (E-system) work well for functional prediction of surface finish in the analysis of surfaces in contact. The naive algorithms are time consuming, especially for areal data, and not generally adopted in real practice. A fast algorithm is proposed based on the alpha shape. The hull obtained by rolling the alpha ball is equivalent to the morphological opening/closing in theory. The algorithm depends on Delaunay triangulation with time complexity O(nlogn). In comparison to the naive algorithms it generates the opening and closing envelope without combining dilation and erosion. Edge distortion is corrected by reflective padding for open profiles/surfaces. Spikes in the sample data are detected and points interpolated to prevent singularities. The proposed algorithm works well both for morphological profile and area filters. Examples are presented to demonstrate the validity and superiority on efficiency of this algorithm over the naive algorithm.

  11. Fast spin-echo imaging

    International Nuclear Information System (INIS)

    Mackey, K.; Zoarski, G.; Bentson, J.R.; Lufkin, R.B.; Melki, P.; Jolesz, F.

    1991-01-01

    This paper reports on a partial radio-frequency (RF) echo-planar pulse sequence called contiguous slice fast spin echo (CSFSE) which is undergoing clinical trials for spine MR imaging. In this variation of rapid acquisition relaxation enhanced (RARE) spin-echo imaging, rapid 180 degrees RF pulse generated refocused echoes, producing T2-weighted images in about one-third the time of conventional double-echo technique. Forty patients with suspected pathology of the spine were imaged with conventional double-echo and closely matched CSFSE techniques on a GE Signa 1.5-T Advantage system. Cases were reviewed by two board-certified neuroradiologists. In all cases the CSFSE images were of equal or superior quality compared with those obtained with the conventional double-echo technique. Pathologic processes that were imaged consisted of inflammatory, neoplastic, posttraumatic, and degenerative conditions

  12. On Grounding of Fast Ships

    DEFF Research Database (Denmark)

    Simonsen, Bo Cerup; Pedersen, Preben Terndrup

    1997-01-01

    The paper deals with analysis of grounding of high-speed crafts. It is the purpose to present a comprehensive mathematical model for calculation of the overall dynamic ship response during grounding. This procedure is applied to derive the motions, the time varying sectional forces and the local...... loads during grounding on plane, sloping, sandy bottoms for six different designs of fast monohull ships made from steel, aluminium or GRP sandwich materials. The results show that the effect of the hull flexibility is to reduce the overall dynamic sectional loads on the hull girder. The considered...... numerical examples also indicate that, even with impact speeds of 40 knots against a 1:10 sloping bottom, the global strength of the hull girder is not exceeded by the grounding induced loads.For the local deformation of high-speed ship hulls at the point of contact with the ground, the paper presents...

  13. Holography for fast reactor inspection

    International Nuclear Information System (INIS)

    Tozer, B.A.

    1980-01-01

    Holography, an optical process whereby an image of the original subject can be reconstructed in three dimensions, is being developed for use as an optical inspection tool. With a potential information storage density of 10 16 bits/m 2 , the ability to reconstruct in 3 dimensions, a depth of field of up to 8 metres, extremely wide angle of view, and potentially diffraction limited resolution, holography should be invaluable for the optical recording of fast reactors during construction, and the inspection of optically accessible regions during operation, or maintenance down-times. The photographic emulsions used for high resolution holography are fine-grained and fog only very slowly when subjected to γ-radiation, so that inspection of highly radio-active regions and components can be effected satisfactorily. Some of the practical limitations affecting holography are described and ways of overcoming them discussed. Some preliminary results are presented. (author)

  14. Integral fast reactor safety features

    International Nuclear Information System (INIS)

    Cahalan, J.E.; Kramer, J.M.; Marchaterre, J.F.; Mueller, C.J.; Pedersen, D.R.; Sevy, R.H.; Wade, D.C.; Wei, T.Y.C.

    1988-01-01

    The integral fast reactor (IFR) is an advanced liquid-metal-cooled reactor concept being developed at Argonne National Laboratory. The two major goals of the IFR development effort are improved economics and enhanced safety. In addition to liquid metal cooling, the principal design features that distinguish the IFR are: a pool-type primary system, and advanced ternary alloy metallic fuel, and an integral fuel cycle with on-site fuel reprocessing and fabrication. This paper focuses on the technical aspects of the improved safety margins available in the IFR concept. This increased level of safety is made possible by the liquid metal (sodium) coolant and pool-type primary system layout, which together facilitate passive decay heat removal, and a sodium-bonded metallic fuel pin design with thermal and neutronic properties that provide passive core responses which control and mitigate the consequences of reactor accidents

  15. Fast wall of thermonuclear device

    International Nuclear Information System (INIS)

    Kitamura, Kazunori.

    1990-01-01

    A protruding molten metal reservoir is disposed to a sealing vessel embedded in the armour tile of fast walls, and molten metal of low melting point such as tin, lead or alloy thereof is filled in the sealing vessel. The volume of the molten metal reservoir is determined such that the surface level of the molten metal is kept within the molten metal reservoir even when the sealed low melting point metal is solidified at room temperature. When the temperature is lowered during plasma interruption period and the sealed low melting molten metal is solidified to reduce the volume, most of the molten metal reservoir regioin constitutes a vacuum gap. However, the inner wall of the sealing vessel other than the molten metal reservior region can be kept into contact with the sealed metal. Accordingly, the temperature and the sublimation loss of the armour tile can be kept low even upon plasma heat application. (I.N.)

  16. Fast form alpha-2-macroglobulin

    DEFF Research Database (Denmark)

    Biltoft, Daniel; Gram, Jørgen Brodersen; Larsen, Anette

    2017-01-01

    Objectives: Investigation of the blood compatibility requires a number of sensitive assays to quantify the activation of the blood protein cascades and cells induced by biomaterials. A global assay measuring the blood compatibility of biomaterials could be a valuable tool in such regard....... In this study, we investigated whether an enzyme-linked immunosorbent assay (ELISA), that specifically measures the electrophoretic "fast form" of α2-macroglobulin (F-α2M), could be a sensitive and global marker for activation of calcium dependent and in-dependent proteases in plasma exposed to biomaterials...... in vitro. Methods: A F-α2M specific monoclonal antibody was generated and applied in an ELISA setup. Using the F-α2M ELISA, we investigated activation of calcium dependent and in-dependent proteases by polyvinylchloride (n=10), polytetrafluoroethylene (n=10) and silicone (n=10) tubings as well as glass...

  17. Measurement of fast transient pressures

    International Nuclear Information System (INIS)

    Procaccia, Henri

    1978-01-01

    The accuracy, reliability and sensitivity of a pressure transducers define its principal static characteristics. When the quantity measured varies with time, the measurement carries a dynamic error and a delay depending on the frequency of this variation. Hence, when fast pressure changes in a fluid have to be determined, different kinds of pressure transducers can be used depending on their inherent dynamic characteristics which must be compared with those of the transient phenomenon to be analysed. The text describes the pressure transducers generally employed in industry for analysing such phenomenon and gives two practical applications developed in the EDF: the first submits the measurements and results of pump cavitation tests carried out at the Vitry II EDF power station; the second deals with hammer blows particularly noticed in nuclear power stations and required the use of transducers of exceptionally high performance such as strain gauge transducers and piezoelectric transducers (response time within 1m sec.) [fr

  18. Single bunch fast longitudinal instability

    International Nuclear Information System (INIS)

    Wang, J.M.; Pellegrini, C.

    1979-01-01

    Single bunch longitudinal instability producing an increase of the bunch areas has been observed in proton synchrotron and storage rings. Singals at microwave frequencies are observed during the bunch blow-up and because of this the effect has been called the microwave instability. A similar increase in bunch area is observed also in electron storage rings, where it is usually referred to as the bunch lengthening effect. This paper is an attempt to obtain a more general theory of this effect. Here we describe the model used and the method of calculation, together with some general results. The main result of this paper is the derivation of a condition for the existence of a fast longitudinal bunch blow-up. This condition is a generalized threshold formula, showing explicitly the dependence on the bunch energy spread and length

  19. Interfacial effects in fast reactors

    International Nuclear Information System (INIS)

    Saidi, M.S.; Driscoll, M.J.

    1979-05-01

    The problem of increased resonance capture rates near zone interfaces in fast reactor media has been examined both theoretically and experimentally. An interface traversing assembly was designed, constructed and employed to measure U-238 capture rates near th blanket--reflector interface in the MIT Blanket Test Facility. Prior MIT experiments on a thorium--uranium interface in a blanket assembly were also reanalyzed. Extremely localized fertile capture rate increases of on the order of 50% were measured immediately at the interfaces relative to extrapolation of asymptotic interior traverses, and relative to state-of-the-art (LIB-IV, SPHINX, ANISN/2DB) calculations which employ infinite-medium self-shielding throughout a given zone. A method was developed to compute a spatially varying background scattering cross section per absorber nucleus which takes into account both homogeneous and heterogeneous effects on the interface flux transient

  20. Fast-scan NMR imaging

    International Nuclear Information System (INIS)

    Iwaoka, Hideto; Matsuura, Hiroyuki; Sugiyama, Tadashi; Hirata, Takaaki

    1987-01-01

    This paper describes the Fast Recovery (FR) method for fast-scan Nuclear Magnetic Resonance imaging. The FR method uses a sequence of four radio frequency pulses - alternating selective 90 deg nutation pulses and nonselective 180 deg pulses. One free induction decay (FID) signal and one echo signal are detected and averaged to compute a 2-D image. In the modified FR method, extra 180 deg pulses are applied between 90 deg pulses to cause refocusing and the resultant spin echo signals are averaged to improve the signal to noise ratio. For the FR and modified FR sequences, the macroscopic magnetization is restored to equilibrium quickly and exactly; scan time can consequently be less than that for conventional pulse sequences, such as used in the saturation recovery method, without any penalty in signal to noise ratio. This paper derives expressions for the signal to noise ratio, scan time ratio and contrast noise ratio, compares the FR and modified FR methods with the saturation recovery method and presents experimental results for human body images. In theory and practice, the signal to noise ratio for the FR method is larger than that for the modified FR method. For a given signal to noise ratio the scan time is between one half and one fourth that for the saturation recovery method. The optimum repetition period, T r , is 0.07 ∼ 0.25 s for the FR method, and 0.1 ∼ 0.5 s for the modified FR method. Contrast noise ratio is low for high speed imaging, T r = 0.07 ∼ 0.25 s, but, high contrast noise ratio image is obtained for T r > 0.5 s. (author)

  1. FastBit Reference Manual

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Kesheng

    2007-08-02

    An index in a database system is a data structure that utilizes redundant information about the base data to speed up common searching and retrieval operations. Most commonly used indexes are variants of B-trees, such as B+-tree and B*-tree. FastBit implements a set of alternative indexes call compressed bitmap indexes. Compared with B-tree variants, these indexes provide very efficient searching and retrieval operations by sacrificing the efficiency of updating the indexes after the modification of an individual record. In addition to the well-known strengths of bitmap indexes, FastBit has a special strength stemming from the bitmap compression scheme used. The compression method is called the Word-Aligned Hybrid (WAH) code. It reduces the bitmap indexes to reasonable sizes and at the same time allows very efficient bitwise logical operations directly on the compressed bitmaps. Compared with the well-known compression methods such as LZ77 and Byte-aligned Bitmap code (BBC), WAH sacrifices some space efficiency for a significant improvement in operational efficiency. Since the bitwise logical operations are the most important operations needed to answer queries, using WAH compression has been shown to answer queries significantly faster than using other compression schemes. Theoretical analyses showed that WAH compressed bitmap indexes are optimal for one-dimensional range queries. Only the most efficient indexing schemes such as B+-tree and B*-tree have this optimality property. However, bitmap indexes are superior because they can efficiently answer multi-dimensional range queries by combining the answers to one-dimensional queries.

  2. Physical studies of fast ignition in China

    International Nuclear Information System (INIS)

    He, X T; Cai, Hong-bo; Wu, Si-zhong; Cao, Li-hua; Zhang, Hua; He, Ming-qing; Chen, Mo; Wu, Jun-feng; Zhou, Cang-tao; Zhou, Wei-Min; Shan, Lian-qiang; Wang, Wei-wu; Zhang, Feng; Bi, Bi; Zhao, Zong-qing; Gu, Yu-qiu; Zhang, Bao-han; Wang, Wei; Fang, Zhi-heng; Lei, An-le

    2015-01-01

    Fast ignition approach to inertial confinement fusion is one of the important goals today, in addition to central hot spot ignition in China. The SG-IIU and PW laser facilities are coupled to investigate the hot spot formation for fast ignition. The SG-III laser facility is almost completed and will be coupled with tens kJ PW lasers for the demonstration of fast ignition. In recent years, for physical studies of fast ignition, we have been focusing on the experimental study of implosion symmetry, M-band radiation preheating and mixing, advanced fast ignition target design, and so on. In addition, the modeling capabilities and code developments enhanced our ability to perform the hydro-simulation of the compression implosion, and the particle-in-cell (PIC) and hybrid-PIC simulation of the generation, transport and deposition of relativistic electron beams. Considerable progress has been achieved in understanding the critical issues of fast ignition. (paper)

  3. Should Type 1 diabetics fast in Ramadan.

    Science.gov (United States)

    Mohsin, Fauzia; Azad, Kishwar; Zabeen, Bedowra; Tayyeb, Samin; Baki, Abdul; Nahar, Nazmun

    2015-05-01

    Fasting during the holy month of Ramadan is obligatory for all healthy adult and adolescent Muslims from the age of 12 years. This involves abstaining from eating or drinking from early dawn (Suhur/Sehri) till sunset (Iftar).Fasting is not meant to create excessive hardships or impart any adverse effect to the Muslim individual. As such, Islam has exempted certain categories of people from fasting including young children, travelers, the sick, the elderly,and pregnant and lactating women. According to expert opinion, people with type 1 diabetes who fast during Ramadan are at very high risk of metabolic deterioration. However, some recent studies have demonstrated that individuals with type 1 diabetes who are otherwise healthy and stable, can fast during Ramadan provided they comply with the Ramadan focused management plan and are under close professional supervision. This article discusses how to assess, counsel, monitor and manage people with type 1 diabetes who wish to fast during Ramadan.

  4. International Experience with Fast Reactor Operation & Testing

    International Nuclear Information System (INIS)

    Sackett, John I.; Grandy, C.

    2013-01-01

    Conclusion: • Worldwide experience with fast reactors has demonstrated the robustness of the technology and it stands ready for worldwide deployment. • The lessons learned are many and there is danger that what has been learned will be forgotten given that there is little activity in fast reactor development at the present time. • For this reason it is essential that knowledge of fast reactor technology be preserved, an activity supported in the U.S. as well as other countries

  5. Fasting: Molecular Mechanisms and Clinical Applications

    OpenAIRE

    Longo, Valter D.; Mattson, Mark P.

    2014-01-01

    Fasting has been practiced for millennia, but only recently studies have shed light on its role in adaptive cellular responses that reduce oxidative damage and inflammation, optimize energy metabolism and bolster cellular protection. In lower eukaryotes, chronic fasting extends longevity in part by reprogramming metabolic and stress resistance pathways. In rodents intermittent or periodic fasting protects against diabetes, cancers, heart disease and neurodegeneration, while in humans it helps...

  6. Psychology into economics: fast and frugal heuristics

    OpenAIRE

    Schilirò, Daniele

    2015-01-01

    The present essay focuses on the fast and frugal heuristics program set forth by Gerd Gigerenzer and his fellows. In particular it examines the contribution of Gigerenzer and Goldstein (1996) ‘Reasoning the Fast and Frugal Way: Models of Bounded Rationality’. This essay, following the theoretical propositions and the empirical evidence of Gigerenzer and Goldstein, points out that simple cognitive mechanisms such as fast and frugal heuristics can be capable of successful performance in real wo...

  7. Fasting guidelines for diabetic children and adolescents

    OpenAIRE

    Azad, Kiswhar; Mohsin, Fauzia; Zargar, Abdul Hamid; Zabeen, Bedowra; Ahmad, Jamal; Raza, Syed Abbas; Tayyeb, Samin; Bajaj, Sarita; Ishtiaq, Osama; Kalra, Sanjay

    2012-01-01

    Fasting during the month of Ramadan, the ninth month of Islamic lunar calendar, is obligatory for all healthy adult and adolescent Muslims from the age of 12 years. Fasting starts from early dawn (Sohur/Sehri) till sunset (Iftar). During this period one has to abstain from eating and drinking. Islam has allowed many categories of people to be exempted from fasting, for example, young children, travelers, the sick, the elderly, pregnant, and lactating women. According to expert opinion, patien...

  8. Fast decoding algorithms for coded aperture systems

    International Nuclear Information System (INIS)

    Byard, Kevin

    2014-01-01

    Fast decoding algorithms are described for a number of established coded aperture systems. The fast decoding algorithms for all these systems offer significant reductions in the number of calculations required when reconstructing images formed by a coded aperture system and hence require less computation time to produce the images. The algorithms may therefore be of use in applications that require fast image reconstruction, such as near real-time nuclear medicine and location of hazardous radioactive spillage. Experimental tests confirm the efficacy of the fast decoding techniques

  9. Fast breeder reactors an engineering introduction

    CERN Document Server

    Judd, A M

    1981-01-01

    Fast Breeder Reactors: An Engineering Introduction is an introductory text to fast breeder reactors and covers topics ranging from reactor physics and design to engineering and safety considerations. Reactor fuels, coolant circuits, steam plants, and control systems are also discussed. This book is comprised of five chapters and opens with a brief summary of the history of fast reactors, with emphasis on international and the prospect of making accessible enormous reserves of energy. The next chapter deals with the physics of fast reactors and considers calculation methods, flux distribution,

  10. The new ATLAS Fast Calorimeter Simulation

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00223142; The ATLAS collaboration

    2017-01-01

    Current and future need for large scale simulated samples motivate the development of reliable fast simulation techniques. The new Fast Calorimeter Simulation is an improved parameterized response of single particles in the ATLAS calorimeter that aims to accurately emulate the key features of the detailed calorimeter response as simulated with Geant4, yet approximately ten times faster. Principal component analysis and machine learning techniques are used to improve the performance and decrease the memory need compared to the current version of the ATLAS Fast Calorimeter Simulation. A prototype of this new Fast Calorimeter Simulation is in development and its integration into the ATLAS simulation infrastructure is ongoing.

  11. The new ATLAS Fast Calorimeter Simulation

    Science.gov (United States)

    Schaarschmidt, J.; ATLAS Collaboration

    2017-10-01

    Current and future need for large scale simulated samples motivate the development of reliable fast simulation techniques. The new Fast Calorimeter Simulation is an improved parameterized response of single particles in the ATLAS calorimeter that aims to accurately emulate the key features of the detailed calorimeter response as simulated with Geant4, yet approximately ten times faster. Principal component analysis and machine learning techniques are used to improve the performance and decrease the memory need compared to the current version of the ATLAS Fast Calorimeter Simulation. A prototype of this new Fast Calorimeter Simulation is in development and its integration into the ATLAS simulation infrastructure is ongoing.

  12. Impact of intermittent fasting on glucose homeostasis.

    Science.gov (United States)

    Varady, Krista A

    2016-07-01

    This article provides an overview of the most recent human trials that have examined the impact of intermittent fasting on glucose homeostasis. Our literature search retrieved one human trial of alternate day fasting, and three trials of Ramadan fasting published in the past 12 months. Current evidence suggests that 8 weeks of alternate day fasting that produces mild weight loss (4% from baseline) has no effect on glucose homeostasis. As for Ramadan fasting, decreases in fasting glucose, insulin, and insulin resistance have been noted after 4 weeks in healthy normal weight individuals with mild weight loss (1-2% from baseline). However, Ramadan fasting may have little impact on glucoregulatory parameters in women with polycystic ovarian syndrome who failed to observe weight loss. Whether intermittent fasting is an effective means of regulating glucose homeostasis remains unclear because of the scarcity of studies in this area. Large-scale, longer-term randomized controlled trials will be required before the use of fasting can be recommended for the prevention and treatment of metabolic diseases.

  13. A fast-slow logic system

    International Nuclear Information System (INIS)

    Kawashima, Hideo.

    1977-01-01

    A fast-slow logic system has been made for use in multi-detector experiments in nuclear physics such as particle-gamma and particle-particle coincidence experiments. The system consists of a fast logic system and a slow logic system. The fast logic system has a function of fast coincidences and provides timing signals for the slow logic system. The slow logic system has a function of slow coincidences and a routing control of input analog signals to the ADCs. (auth.)

  14. Fast-track totalknæalloplastik

    DEFF Research Database (Denmark)

    Gromov, Kirill; Kristensen, Billy B; Jørgensen, Christoffer Calov

    2017-01-01

    patients are eligible for fast-track TKA, and hence the fast-track concept should be standard at all joint replacement facilities. Future challenges of fast-track TKA include safe introduction of outpatient protocols, acute and chronic pain after surgery and optimal utilization of post......Fast-track total knee arthroplasty (TKA) is a well-established concept including optimized logistics and evidence-based treatment, focusing on minimizing surgical stress and improved post-operative recovery, thus leading to lower mortality and morbidity as well as high patient satisfaction. All...

  15. Fasting: molecular mechanisms and clinical applications.

    Science.gov (United States)

    Longo, Valter D; Mattson, Mark P

    2014-02-04

    Fasting has been practiced for millennia, but, only recently, studies have shed light on its role in adaptive cellular responses that reduce oxidative damage and inflammation, optimize energy metabolism, and bolster cellular protection. In lower eukaryotes, chronic fasting extends longevity, in part, by reprogramming metabolic and stress resistance pathways. In rodents intermittent or periodic fasting protects against diabetes, cancers, heart disease, and neurodegeneration, while in humans it helps reduce obesity, hypertension, asthma, and rheumatoid arthritis. Thus, fasting has the potential to delay aging and help prevent and treat diseases while minimizing the side effects caused by chronic dietary interventions. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. Fasting: Molecular Mechanisms and Clinical Applications

    Science.gov (United States)

    Longo, Valter D.; Mattson, Mark P.

    2014-01-01

    Fasting has been practiced for millennia, but only recently studies have shed light on its role in adaptive cellular responses that reduce oxidative damage and inflammation, optimize energy metabolism and bolster cellular protection. In lower eukaryotes, chronic fasting extends longevity in part by reprogramming metabolic and stress resistance pathways. In rodents intermittent or periodic fasting protects against diabetes, cancers, heart disease and neurodegeneration, while in humans it helps reduce obesity, hypertension, asthma and rheumatoid arthritis. Thus, fasting has the potential to delay aging and help prevent and treat diseases while minimizing the side effects caused by chronic dietary interventions. PMID:24440038

  17. LTFR-4, Library Generated for Fast Reactor Design Program from JAERI Fast-Set Multigroup Constant

    International Nuclear Information System (INIS)

    Suzuki, Tomoo

    1971-01-01

    Nature of physical problem solved: The program processes JAERI-Fast group constants sets of less than 30-group and prepares a binary library tape for efficient usage by a series of related fast reactor design calculation programmes

  18. Intermediate and fast neutron absorbed doses in fast neutron field at the RB reactor

    International Nuclear Information System (INIS)

    Sokcic-Kostic, M.; Pesic, M.; Antic, D.

    1987-10-01

    The experimental fuel channel EFC is created as one of the fast neutron fields at the RB reactor. The intermediate and fast neutron spectra in EFC are measured by activation technique. The intermediate and fast neutron absorbed doses are computed on the basis of these experimental results. At the end the obtained doses are compared. (author)

  19. The UK commercial demonstration fast reactor design

    International Nuclear Information System (INIS)

    Holmes, J.A.G.

    1987-01-01

    The paper on the UK Commercial Demonstration Fast Reactor design was presented to the seminar on 'European Commercial Fast Reactor Programme, London 1987. The design is discussed under the topic headings:- primary circuit, intermediate heat exchangers and pumps, fuel and core, refuelling, steam generators, and nuclear island layout. (U.K.)

  20. Predictors of Ramadan fasting during pregnancy

    NARCIS (Netherlands)

    van Bilsen, Lily A.; Savitri, Ary I.; Amelia, Dwirani; Baharuddin, Mohammad; Grobbee, Diederick E.; Uiterwaal, Cuno S P M

    2016-01-01

    Although the health effects of Ramadan fasting during pregnancy are still unclear, it is important to identify the predictors and motivational factors involved in women's decision to observe the fast. We investigated these factors in a cross sectional study of 187 pregnant Muslim women who attended

  1. Metabolic Profiles in Children During Fasting

    NARCIS (Netherlands)

    van Veen, Merel R.; van Hasselt, Peter M.; de Sain-van der Velden, Monique G. M.; Verhoeven, Nanda; Hofstede, Floris C.; de Koning, Tom J.; Visser, Gepke

    BACKGROUND: Hypoglycemia is one of the most common metabolic derangements in childhood. To establish the cause of hypoglycemia, fasting tolerance tests can be used. Currently available reference values for fasting tolerance tests have limitations in their use in daily practice. OBJECTIVE: The aim of

  2. Advanced Safeguards Approaches for New Fast Reactors

    International Nuclear Information System (INIS)

    Durst, Philip C.; Therios, Ike; Bean, Robert; Dougan, A.; Boyer, Brian; Wallace, Rick L.; Ehinger, Michael H.; Kovacic, Don N.; Tolk, K.

    2007-01-01

    This third report in the series reviews possible safeguards approaches for new fast reactors in general, and the ABR in particular. Fast-neutron spectrum reactors have been used since the early 1960s on an experimental and developmental level, generally with fertile blanket fuels to 'breed' nuclear fuel such as plutonium. Whether the reactor is designed to breed plutonium, or transmute and 'burn' actinides depends mainly on the design of the reactor neutron reflector and the whether the blanket fuel is 'fertile' or suitable for transmutation. However, the safeguards issues are very similar, since they pertain mainly to the receipt, shipment and storage of fresh and spent plutonium and actinide-bearing 'TRU'-fuel. For these reasons, the design of existing fast reactors and details concerning how they have been safeguarded were studied in developing advanced safeguards approaches for the new fast reactors. In this regard, the design of the Experimental Breeder Reactor-II 'EBR-II' at the Idaho National Laboratory (INL) was of interest, because it was designed as a collocated fast reactor with a pyrometallurgical reprocessing and fuel fabrication line--a design option being considered for the ABR. Similarly, the design of the Fast Flux Facility (FFTF) on the Hanford Site was studied, because it was a successful prototype fast reactor that ran for two decades to evaluate fuels and the design for commercial-scale fast reactors

  3. A new electret dosimeter for fast neutrons

    International Nuclear Information System (INIS)

    Campos, L.L.; Suarez, A.A.; Mascarenhas, S.

    1982-01-01

    A new electret for fast-neutron personnel dosimetry is described and calibration curves obtained. Its performance may be improved by changes in the wall composition and geometric parameters. The advantages of electrets over TL and film are the non-erasure of information, low cost, fast reading and portability. (U.K.)

  4. A silicon diode for fast neutron dosimetry

    International Nuclear Information System (INIS)

    Anon.

    1983-01-01

    The effect of fast neutrons on both animate and inanimate objects, including human beings, can be extremely serious and cumulative. There is thus a need for a small, simple and cheap component which will provide a permanent or semi-permanent record of the accumulated fast neutron dose

  5. Advanced Safeguards Approaches for New Fast Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Durst, Philip C.; Therios, Ike; Bean, Robert; Dougan, A.; Boyer, Brian; Wallace, Rick L.; Ehinger, Michael H.; Kovacic, Don N.; Tolk, K.

    2007-12-15

    This third report in the series reviews possible safeguards approaches for new fast reactors in general, and the ABR in particular. Fast-neutron spectrum reactors have been used since the early 1960s on an experimental and developmental level, generally with fertile blanket fuels to “breed” nuclear fuel such as plutonium. Whether the reactor is designed to breed plutonium, or transmute and “burn” actinides depends mainly on the design of the reactor neutron reflector and the whether the blanket fuel is “fertile” or suitable for transmutation. However, the safeguards issues are very similar, since they pertain mainly to the receipt, shipment and storage of fresh and spent plutonium and actinide-bearing “TRU”-fuel. For these reasons, the design of existing fast reactors and details concerning how they have been safeguarded were studied in developing advanced safeguards approaches for the new fast reactors. In this regard, the design of the Experimental Breeder Reactor-II “EBR-II” at the Idaho National Laboratory (INL) was of interest, because it was designed as a collocated fast reactor with a pyrometallurgical reprocessing and fuel fabrication line – a design option being considered for the ABR. Similarly, the design of the Fast Flux Facility (FFTF) on the Hanford Site was studied, because it was a successful prototype fast reactor that ran for two decades to evaluate fuels and the design for commercial-scale fast reactors.

  6. Faste vendinger med en bestemt betydning

    DEFF Research Database (Denmark)

    Bergenholtz, Henning; Bjærge, Esben

    2012-01-01

    Ordbogen giver oplysnnger om ca. 17.000 idiomer, ordsprog, bevingede ord og andre faste vendinger, som kan findes og er ordnet efter betydningen.......Ordbogen giver oplysnnger om ca. 17.000 idiomer, ordsprog, bevingede ord og andre faste vendinger, som kan findes og er ordnet efter betydningen....

  7. Fast reactor fuel reprocessing. An Indian perspective

    International Nuclear Information System (INIS)

    Natarajan, R.; Raj, Baldev

    2005-01-01

    The Department of Atomic Energy (DAE) envisioned the introduction of Plutonium fuelled fast reactors as the intermediate stage, between Pressurized Heavy Water Reactors and Thorium-Uranium-233 based reactors for the Indian Nuclear Power Programme. This necessitated the closing of the fast reactor fuel cycle with Plutonium rich fuel. Aiming to develop a Fast Reactor Fuel Reprocessing (FRFR) technology with low out of pile inventory, the DAE, with over four decades of operating experience in Thermal Reactor Fuel Reprocessing (TRFR), had set up at the India Gandhi Center for Atomic Research (IGCAR), Kalpakkam, R and D facilities for fast reactor fuel reprocessing. After two decades of R and D in all the facets, a Pilot Plant for demonstrating FRFR had been set up for reprocessing the FBTR (Fast Breeder Test Reactor) spent mixed carbide fuel. Recently in this plant, mixed carbide fuel with 100 GWd/t burnup fuel with short cooling period had been successfully reprocessed for the first time in the world. All the challenging problems encountered had been successfully overcome. This experience helped in fine tuning the designs of various equipments and processes for the future plants which are under construction and design, namely, the DFRP (Demonstration Fast reactor fuel Reprocessing Plant) and the FRP (Fast reactor fuel Reprocessing Plant). In this paper, a comprehensive review of the experiences in reprocessing the fast reactor fuel of different burnup is presented. Also a brief account of the various developmental activities and strategies for the DFRP and FRP are given. (author)

  8. Nutrient quality of fast food kids meals

    Science.gov (United States)

    Exposure of children to kids’ meals at fast food restaurants is high; however, the nutrient quality of such meals has not been systematically assessed. We assessed the nutrient quality of fast food meals marketed to young children, i.e., "kids meals". The nutrient quality of kids’ meals was assessed...

  9. Aspects of the fast reactors fuel cycle

    International Nuclear Information System (INIS)

    Zouain, D.M.

    1982-06-01

    The fuel cycle for fast reactors, is analysed, regarding the technical aspects of the developing of the reprocessing stages and the fuel fabrication. The environmental impact of LMFBRs and the waste management of this cycle are studied. The economic aspects of the fuel cycle, are studied too. Some coments about the Brazilian fast reactors programs are done. (E.G.) [pt

  10. Can fast and slow intelligence be differentiated?

    NARCIS (Netherlands)

    Partchev, I.; de Boeck, P.

    2012-01-01

    Responses to items from an intelligence test may be fast or slow. The research issue dealt with in this paper is whether the intelligence involved in fast correct responses differs in nature from the intelligence involved in slow correct responses. There are two questions related to this issue: 1.

  11. Fast-track revision knee arthroplasty

    DEFF Research Database (Denmark)

    Husted, Henrik; Otte, Niels Kristian Stahl; Kristensen, Billy B

    2011-01-01

    Abstract Background and purpose Fast-track surgery has reduced the length of hospital stay (LOS), morbidity, and convalescence in primary hip and knee arthroplasty (TKA). We assessed whether patients undergoing revision TKA for non-septic indications might also benefit from fast-track surgery...

  12. Review of Fast Reactor Activities, March 1980

    International Nuclear Information System (INIS)

    Balz, W.

    1980-01-01

    As in previous years, a short outline of the major achievements made since the last IWGFR meeting is given in the following. On 18 February 1980 the Council of Ministers has approved a resolution in which they recognise the strategic importance of fast breeder reactors and the need to continue the efforts towards maintaining an effective fast breeder option in the Member States

  13. Analytical model for fast-shock ignition

    International Nuclear Information System (INIS)

    Ghasemi, S. A.; Farahbod, A. H.; Sobhanian, S.

    2014-01-01

    A model and its improvements are introduced for a recently proposed approach to inertial confinement fusion, called fast-shock ignition (FSI). The analysis is based upon the gain models of fast ignition, shock ignition and considerations for the fast electrons penetration into the pre-compressed fuel to examine the formation of an effective central hot spot. Calculations of fast electrons penetration into the dense fuel show that if the initial electron kinetic energy is of the order ∼4.5 MeV, the electrons effectively reach the central part of the fuel. To evaluate more realistically the performance of FSI approach, we have used a quasi-two temperature electron energy distribution function of Strozzi (2012) and fast ignitor energy formula of Bellei (2013) that are consistent with 3D PIC simulations for different values of fast ignitor laser wavelength and coupling efficiency. The general advantages of fast-shock ignition in comparison with the shock ignition can be estimated to be better than 1.3 and it is seen that the best results can be obtained for the fuel mass around 1.5 mg, fast ignitor laser wavelength ∼0.3  micron and the shock ignitor energy weight factor about 0.25

  14. Is fasting necessary for elective cerebral angiography?

    Science.gov (United States)

    Kwon, O-K; Oh, C W; Park, H; Bang, J S; Bae, H-J; Han, M K; Park, S-H; Han, M H; Kang, H-S; Park, S-K; Whang, G; Kim, B-C; Jin, S-C

    2011-05-01

    In order to prevent unexpected events such as aspiration pneumonia, cerebral angiography has been performed under fasting in most cases. We investigated prospectively the necessity of fasting before elective cerebral angiography. The study is an open-labeled clinical trial without random allocation. In total, 2554 patients who underwent elective cerebral angiography were evaluated on development of nausea, vomiting, and pulmonary aspiration during and after angiography. Potential risks and benefits associated with fasting were provided in written documents and through personal counseling to patients before the procedure. The patients chose their fasting or nonfasting option. No restriction in diet was given after angiography. The patients were observed for 24 hours. Nausea and vomiting during and within 1 hour after angiography was considered as a positive event associated with cerebral angiography. The overall incidence of nausea and vomiting during and within 1 hour after angiography was 1.05% (27/2554 patients). There was no patient with pulmonary aspiration. No statistical difference in nausea and vomiting development between the fasting and the diet groups was found. The incidence of nausea and vomiting associated with cerebral angiography is low and not affected by diet or fasting. Pulmonary aspiration had no difference between the diet and the fasting group. Our study suggests that fasting may not be necessary for patients who undergo elective cerebral angiography.

  15. Fasting the Microbiota to Improve Metabolism?

    Science.gov (United States)

    Haas, Joel T; Staels, Bart

    2017-10-03

    While intermittent or periodic fasting provides a variety of favorable health benefits, the molecular mediators of these effects are poorly understood. In this issue of Cell Metabolism, Li and colleagues (2017) highlight the role of gut microbiota in mediating benefits of intermittent fasting through activation of adipose tissue beiging. Copyright © 2017. Published by Elsevier Inc.

  16. Advances by the Integral Fast Reactor Program

    International Nuclear Information System (INIS)

    Lineberry, M.J.; Pedersen, D.R.; Walters, L.C.; Cahalan, J.E.

    1991-01-01

    The advances by the Integral Fast Reactor Program at Argonne National Laboratory are the subject of this paper. The Integral Fast Reactor (IFR) is an advanced liquid-metal-cooled reactor concept being developed at Argonne National Laboratory. The advances stressed in the paper include fuel irradiation performance, improved passive safety, and the development of a prototype fuel cycle facility. 14 refs

  17. The RHIC injection fast kicker

    International Nuclear Information System (INIS)

    Forsyth, E.B.; Pappas, G.C.; Tuozzolo, J.E.; Zhang, W.

    1995-01-01

    The purpose of the injection kicker is to provide the ultimate deflection to the incoming beam from the Alternating Gradient Synchrotron (AGS) into the Relativistic Heavy Ion Collider (RHIC). The beam is kicked in the vertical direction to place it on the equilibrium orbit of RHIC. Each bunch in the AGS is transferred separately, and stacked box-car fashion in the appropriate RHIC rf bucket. In order to achieve the required deflection angle four magnets powered by four pulsers will be used for each ring of RHIC. When the bunches are stacked in RHIC the last few rf buckets are left unfilled in order to provide a gap in the beam to facilitate the ejection or beam abort process. This also means there is not a severe constraint on the fall-time of the injection kicker. One prototype pulser has been built and tested. Much of the development effort has gone into the magnet design. Although lumped ferrite magnets are simpler to build and require less power to reach full field, a transmission line magnet was developed because of the very fast rise-time requirement and the tolerances imposed on the field variation and ripple

  18. Isochoric Implosions for Fast Ignition

    International Nuclear Information System (INIS)

    Clark, D S; Tabak, M

    2007-01-01

    Various gain models have shown the potentially great advantages of Fast Ignition (FI) Inertial Confinement Fusion (ICF) over its conventional hot spot ignition counterpart [e.g., S. Atzeni, Phys. Plasmas 6, 3316 (1999); M. Tabak et al., Fusion Sci. and Technology 49, 254 (2006)]. These gain models, however, all assume nearly uniform-density fuel assemblies. In contrast, conventional ICF implosions yield hollowed fuel assemblies with a high-density shell of fuel surrounding a low-density, high-pressure hot spot. Hence, to realize fully the advantages of FI, an alternative implosion design must be found which yields nearly isochoric fuel assemblies without substantial hot spots. Here, it is shown that a self-similar spherical implosion of the type originally studied by Guderley [Luftfahrtforschung 19, 302 (1942)] may be employed to yield precisely such quasi-isochoric imploded states. The difficulty remains, however, of accessing these self-similarly imploding configurations from initial conditions representing an actual ICF target, namely a uniform, solid-density shell at rest. Furthermore, these specialized implosions must be realized for practicable drive parameters and at the scales and energies of interest in ICF. A direct-drive implosion scheme is presented which meets all of these requirements and reaches a nearly isochoric assembled density of 300 g=cm 3 and areal density of 2.4 g=cm 2 using 485 kJ of laser energy

  19. Ultra-Fast Hadronic Calorimetry

    Energy Technology Data Exchange (ETDEWEB)

    Denisov, Dmitri [Fermilab; Lukić, Strahinja [VINCA Inst. Nucl. Sci., Belgrade; Mokhov, Nikolai [Fermilab; Striganov, Sergei [Fermilab; Ujić, Predrag [VINCA Inst. Nucl. Sci., Belgrade

    2017-12-18

    Calorimeters for particle physics experiments with integration time of a few ns will substantially improve the capability of the experiment to resolve event pileup and to reject backgrounds. In this paper time development of hadronic showers induced by 30 and 60 GeV positive pions and 120 GeV protons is studied using Monte Carlo simulation and beam tests with a prototype of a sampling steel-scintillator hadronic calorimeter. In the beam tests, scintillator signals induced by hadronic showers in steel are sampled with a period of 0.2 ns and precisely time-aligned in order to study the average signal waveform at various locations w.r.t. the beam particle impact. Simulations of the same setup are performed using the MARS15 code. Both simulation and test beam results suggest that energy deposition in steel calorimeters develop over a time shorter than 3 ns providing opportunity for ultra-fast calorimetry. Simulation results for an "ideal" calorimeter consisting exclusively of bulk tungsten or copper are presented to establish the lower limit of the signal integration window.

  20. Fast and scalable inequality joins

    KAUST Repository

    Khayyat, Zuhair

    2016-09-07

    Inequality joins, which is to join relations with inequality conditions, are used in various applications. Optimizing joins has been the subject of intensive research ranging from efficient join algorithms such as sort-merge join, to the use of efficient indices such as (Formula presented.)-tree, (Formula presented.)-tree and Bitmap. However, inequality joins have received little attention and queries containing such joins are notably very slow. In this paper, we introduce fast inequality join algorithms based on sorted arrays and space-efficient bit-arrays. We further introduce a simple method to estimate the selectivity of inequality joins which is then used to optimize multiple predicate queries and multi-way joins. Moreover, we study an incremental inequality join algorithm to handle scenarios where data keeps changing. We have implemented a centralized version of these algorithms on top of PostgreSQL, a distributed version on top of Spark SQL, and an existing data cleaning system, Nadeef. By comparing our algorithms against well-known optimization techniques for inequality joins, we show our solution is more scalable and several orders of magnitude faster. © 2016 Springer-Verlag Berlin Heidelberg

  1. [Fast neutron cross section measurements

    International Nuclear Information System (INIS)

    Knoll, G.F.

    1992-01-01

    From its inception, the Nuclear Data Project at the University of Michigan has concentrated on two major objectives: (1) to carry out carefully controlled nuclear measurements of the highest possible reliability in support of the national nuclear data program, and (2) to provide an educational opportunity for students with interests in experimental nuclear science. The project has undergone a successful transition from a primary dependence on our photoneutron laboratory to one in which our current research is entirely based on a unique pulsed 14 MeV fast neutron facility. The new experimental facility is unique in its ability to provide nanosecond bursts of 14 MeV neutrons under conditions that are ''clean'' and as scatter-free as possible, and is the only one of its type currently in operation in the United States. It has been designed and put into operation primarily by graduate students, and has met or exceeded all of its important initial performance goals. We have reached the point of its routine operation, and most of the data are now in hand that will serve as the basis for the first two doctoral dissertations to be written by participating graduate students. Our initial results on double differential neutron cross sections will be presented at the May 1993 Fusion Reactor Technology Workshop. We are pleased to report that, after investing several years in equipment assembly and optimization, the project has now entered its ''data production'' phase

  2. The Fast TracKer

    CERN Document Server

    Potamianos, Karolos Jozef; The ATLAS collaboration

    2018-01-01

    The Fast Tracker (FTK) is a hardware upgrade to the ATLAS trigger and data acquisition system providing global track reconstruction to the High-Level Trigger (HLT) with the goal to improve pile-up rejection. The FTK processes incoming data from the Pixel and SCT detectors (part of the Inner Detector, ID) at up to 100 kHz using custom electronic boards. ID hits are matched to pre-defined track patterns stored in associative memory (AM) on custom ASICs and data routing, reduction and parameter extraction is achieved with processing on FPGAs. With 8000 AM chips and 2000 FPGAs, the FTK provides enough resources to reconstruct tracks with transverse momentum greater than 1 GeV/c in the whole tracking volume with an average latency below 100 microseconds at collisions intensities expected in Runs II and III of the LHC. The tracks will be available at the beginning of the trigger selection process, which allows development of pile-up resilient triggering strategies to identify b-quarks and tau-leptons, as well as pr...

  3. The ATLAS Fast Tracker system

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00353645; The ATLAS collaboration

    2017-01-01

    From 2010 to 2012 the Large Hadron Collider (LHC) operated at a centre-of-mass energy of 7 TeV and 8 TeV, colliding bunches of particles every 50 ns. During operation, the ATLAS trigger system has performed efficiently contributing to important results, including the discovery of the Higgs boson in 2012. The LHC restarted in 2015 and will operate for four years at a center of mass energy of 13 TeV and bunch crossing of 50 ns and 25 ns. These running conditions result in the mean number of overlapping proton-proton interactions per bunch crossing increasing from 20 to 60. The Fast Tracker (FTK) system is designed to deliver full event track reconstruction for all tracks with transverse momentum above 1 GeV at a Level-1 rate of 100 kHz with an average latency below 100 microseconds. This will allow the trigger to utilize tracking information from the entire detector at an earlier event selection stage than ever before, allowing for more efficient event rejection. To achieve this goal the system uses a parallel ...

  4. Fast multichannel analog storage system

    International Nuclear Information System (INIS)

    Freytag, D.R.

    1982-11-01

    A Multichannel Analog Storage System based on a commercial 32-channel parallel in/serial out (PISO) analog shift register is described. The basic unit is a single width CAMAC module containing 512 analog cells and the associated logic for data storage and subsequent readout. At sampling rates of up to 30 MHz the signals are strobed directly into the PISO. At higher rates signals are strobed into a fast presampling stage and subsequently transferred in block form into an array of PISO's. Sampling rates of 300 MHz have been achieved with the present device and 1000 MHz are possible with improved signal drivers. The system is well suited for simultaneous handling of many signal channels with moderate numbers of samples in each channel. RMS noise over full scale signal has been measured as 1:3000 (approx. = 11 bit). However, nonlinearities in the response and differences in sensitivity of the analog cells require an elaborate calibration system in order to realize 11 bit accuracy for the analog information

  5. How fast do eels grow

    International Nuclear Information System (INIS)

    Hansen, H.J.M.

    1988-01-01

    Not so very much about the growth pattern of the eel is known yet. Eels move about nearly all the time. They are thus very difficult to follow and we do not, for examble, yet know how long it actually takes for them to grow to maturity in the wild. So far, a macroscopic analysis of the number of bright and dark areas (growth rings) in the 'earstones' has been used to determine eel age, but this method was recently challenged. Use of radioisotopes has been suggested previously for this purpose. For this present study the rare earth elements, europium-152 and europium-155 are used. When incubated in artificial sea water, a satisfactory final radioactive label was achieved. Two experiments were planned in collaboration with the Swedish Environmental Protection Agency. 2000 Elvers were set out in 1982, in the cooling water outlet of the Oskarshamn nuclear power plant, each marked with europium-155. In 1984 another 10 000 elvers labelled with europium-152 were set out under similar conditions. The idea was mainly to see how fast the eels would grow, and to compare their known age with that determined by examining the earstones. Results showed that there was no clear-cut correlation between actual eel age and the biological age determination used so far. During four years, only 10 of the original 1300 eels were recaptured. It is thus hard to say anything definite from our results on the viability of setting out elvers in the environment

  6. The effect of fasting on surgical performance

    DEFF Research Database (Denmark)

    Schefte, David Fenger; Rosenstock, Steffen Jais

    2016-01-01

    BACKGROUND: It is unknown whether fasting has any impact on surgical performance. This simulator-based study investigates whether fasting affects surgical performance. METHODS: Twelve healthy medical students [seven women, mean age 26.5 years (range 23-34)] with no prior experience with surgical...... simulators underwent a short course introduction to the LapSim(®) simulator. After having reached a predefined level, the participants performed five simulated salpingectomies on the LapSim(®) simulator 5-30 days after the initial introduction. The procedures took place at 9 a.m. and 2 p.m. after fasting...... in the longitudinal axis with the left hand. CONCLUSION: The simulator-based study suggests that 17 h of fasting does not deteriorate surgical performance. Further studies on the effect of fasting on surgical performance are needed....

  7. Economic Issues of Fast Reactor in China

    International Nuclear Information System (INIS)

    Yang Hongyi

    2013-01-01

    Conclusions: 1. More and more fast reactors could be appearing in the world currently and near future. 2. China gets little experience and practice about the economics issues of sodium cooled fast reactors. 3. The economic issues become more and more important for the deplot of fast reactors. Suggestions: 1. An authoritative economic evaluation solution for fast reactor and related fuel cycles facilities is necessary. The solution may be developed by the interested country in order to share the few data, experience and methodology. 2. A new initiative to help to share the economic information for fast reactor and related fuel cycle facilities is necessary. A meeting like TM-44899 organized by the IAEA is very beneficial for this topic and hopefully will continue

  8. Practical Management of Diabetes during Ramadan Fast

    Directory of Open Access Journals (Sweden)

    Sherif IH

    2007-01-01

    Full Text Available Fasting in Ramadan is obligatory for all healthy Muslim adults. No food or drink may be consumed between dawn and sunset [1]. Strictly speaking, the fast of Ramadan is a period of “intermittent fasting” or daily cycles of “alternating” fasting and feeding periods. The periods of the fasting and feeding vary by the geographical locations and by time of the year. During the month of Ramadan, there are two main meals in most Moslem communities. These are commonly referred to by their Arabic origin, namely the “Iftar” (i.e. break of fast immediately after sunset and “Sohur or Suhoor” (i.e. pre-dawn meal. As the Islamic calendar year is lunar, Ramadan (the ninth month therefore starts approximately 10 days earlier each year on the Gregorian calendar. This year, 2007, Ramadan is likely to start between 12th and 14th September.

  9. Fast-track hip and knee arthroplasty

    DEFF Research Database (Denmark)

    Husted, Henrik

    2012-01-01

    Fast-track hip and knee arthroplasty aims at giving the patients the best available treatment at all times, being a dynamic entity. Fast-track combines evidence-based, clinical features with organizational optimization including a revision of traditions resulting in a streamlined pathway from...... on clinical and organizational aspects of fast-track hip and knee arthroplasty (I–IX). A detailed description of the fast-track set-up and its components is provided. Major results include identification of patient characteristics to predict length of stay and satisfaction with different aspects...... of the hospital stay (I); how to optimize analgesia by using a compression bandage in total knee arthroplasty (II); the clinical and organizational set-up facilitating or acting as barriers for early discharge (III); safety aspects following fast-track in the form of few readmissions in general (IV) and few...

  10. Proximity to Fast-Food Outlets and Supermarkets as Predictors of Fast-Food Dining Frequency.

    Science.gov (United States)

    Athens, Jessica K; Duncan, Dustin T; Elbel, Brian

    2016-08-01

    This study used cross-sectional data to test the independent relationship of proximity to chain fast-food outlets and proximity to full-service supermarkets on the frequency of mealtime dining at fast-food outlets in two major urban areas, using three approaches to define access. Interactions between presence of a supermarket and presence of fast-food outlets as predictors of fast-food dining were also tested. Residential intersections for respondents in point-of-purchase and random-digit-dial telephone surveys of adults in Philadelphia, PA, and Baltimore, MD, were geocoded. The count of fast-food outlets and supermarkets within quarter-mile, half-mile, and 1-mile street network buffers around each respondent's intersection was calculated, as well as distance to the nearest fast-food outlet and supermarket. These variables were regressed on weekly fast-food dining frequency to determine whether proximity to fast food and supermarkets had independent and joint effects on fast-food dining. The effect of access to supermarkets and chain fast-food outlets varied by study population. Among telephone survey respondents, supermarket access was the only significant predictor of fast-food dining frequency. Point-of-purchase respondents were generally unaffected by proximity to either supermarkets or fast-food outlets. However, ≥1 fast-food outlet within a 1-mile buffer was an independent predictor of consuming more fast-food meals among point-of-purchase respondents. At the quarter-mile distance, ≥1 supermarket was predictive of fewer fast-food meals. Supermarket access was associated with less fast-food dining among telephone respondents, whereas access to fast-food outlets were associated with more fast-food visits among survey respondents identified at point-of-purchase. This study adds to the existing literature on geographic determinants of fast-food dining behavior among urban adults in the general population and those who regularly consume fast food. Copyright

  11. Predictors of Ramadan fasting during pregnancy

    Directory of Open Access Journals (Sweden)

    Lily A. van Bilsen

    2016-12-01

    Full Text Available Although the health effects of Ramadan fasting during pregnancy are still unclear, it is important to identify the predictors and motivational factors involved in women’s decision to observe the fast. We investigated these factors in a cross sectional study of 187 pregnant Muslim women who attended antenatal care visits in the Budi Kemuliaan Hospital, Jakarta, Indonesia. The odds of adherence to fasting were reduced by 4% for every week increase in gestational age during Ramadan [odds ratio (OR 0.96; 95% confidence interval (CI 0.92, 1.00; p = 0.06] and increased by 10% for every one unit increase of women’s prepregnancy body mass index (BMI (OR 1.10; 95% CI 0.99, 1.23; p = 0.08. Nonparticipation was associated with opposition from husbands (OR 0.34; 95% CI 0.14, 0.82; p = 0.02 and with women’s fear of possible adverse effects of fasting on their own or the baby’s health (OR 0.47; 95% CI 0.22, 1.01; p = 0.05 and OR 0.43; 95% CI 0.21, 0.89; p = 0.02, respectively, although they were attenuated in multivariable analysis. Neither age, income, education, employment, parity, experience of morning sickness, nor fasting during pregnancy outside of Ramadan determined fasting during pregnancy. Linear regression analysis within women who fasted showed that the number of days fasted were inversely associated with women’s gestational age, fear of possible adverse effects of fasting on their own or the fetal health, and with opposition from husbands. In conclusion, earlier gestational age during Ramadan, husband’s opinion and possibly higher prepregnancy BMI, influence women’s adherence to Ramadan fasting during pregnancy. Fear of adverse health effects of Ramadan fasting is common in both fasting and non-fasting pregnant women.

  12. Neighborhood fast food restaurants and fast food consumption: a national study.

    Science.gov (United States)

    Richardson, Andrea S; Boone-Heinonen, Janne; Popkin, Barry M; Gordon-Larsen, Penny

    2011-07-08

    Recent studies suggest that neighborhood fast food restaurant availability is related to greater obesity, yet few studies have investigated whether neighborhood fast food restaurant availability promotes fast food consumption. Our aim was to estimate the effect of neighborhood fast food availability on frequency of fast food consumption in a national sample of young adults, a population at high risk for obesity. We used national data from U.S. young adults enrolled in wave III (2001-02; ages 18-28) of the National Longitudinal Study of Adolescent Health (n = 13,150). Urbanicity-stratified multivariate negative binomial regression models were used to examine cross-sectional associations between neighborhood fast food availability and individual-level self-reported fast food consumption frequency, controlling for individual and neighborhood characteristics. In adjusted analysis, fast food availability was not associated with weekly frequency of fast food consumption in non-urban or low- or high-density urban areas. Policies aiming to reduce neighborhood availability as a means to reduce fast food consumption among young adults may be unsuccessful. Consideration of fast food outlets near school or workplace locations, factors specific to more or less urban settings, and the role of individual lifestyle attitudes and preferences are needed in future research.

  13. Neighborhood fast food restaurants and fast food consumption: A national study

    Directory of Open Access Journals (Sweden)

    Gordon-Larsen Penny

    2011-07-01

    Full Text Available Abstract Background Recent studies suggest that neighborhood fast food restaurant availability is related to greater obesity, yet few studies have investigated whether neighborhood fast food restaurant availability promotes fast food consumption. Our aim was to estimate the effect of neighborhood fast food availability on frequency of fast food consumption in a national sample of young adults, a population at high risk for obesity. Methods We used national data from U.S. young adults enrolled in wave III (2001-02; ages 18-28 of the National Longitudinal Study of Adolescent Health (n = 13,150. Urbanicity-stratified multivariate negative binomial regression models were used to examine cross-sectional associations between neighborhood fast food availability and individual-level self-reported fast food consumption frequency, controlling for individual and neighborhood characteristics. Results In adjusted analysis, fast food availability was not associated with weekly frequency of fast food consumption in non-urban or low- or high-density urban areas. Conclusions Policies aiming to reduce neighborhood availability as a means to reduce fast food consumption among young adults may be unsuccessful. Consideration of fast food outlets near school or workplace locations, factors specific to more or less urban settings, and the role of individual lifestyle attitudes and preferences are needed in future research.

  14. Fasts, feasts and festivals in diabetes-1: Glycemic management during Hindu fasts

    Directory of Open Access Journals (Sweden)

    Sanjay Kalra

    2015-01-01

    Full Text Available This communication is the first of a series on South Asian fasts, festivals, and diabetes, designed to spread awareness and stimulate research on this aspect of diabetes and metabolic care. It describes the various fasts observed as part of Hindu religion and offers a classification scheme for them, labeling them as infrequent and frequent. The infrequent fasts are further sub-classified as brief and prolonged, to facilitate a scientific approach to glycemic management during these fasts. Pre-fast counseling, non-pharmacological therapy, pharmacological modification, and post-fast debriefing are discussed in detail. All available drug classes and molecules are covered in this article, which provides guidance about necessary changes in dosage and timing of administration. While in no way exhaustive, the brief review offers a basic framework which diabetes care professionals can use to counsel and manage persons in their care who wish to observe various Hindu fasts.

  15. A prospective audit of preprocedural fasting practices on a transplant ward: when fasting becomes starving.

    Science.gov (United States)

    Vidot, Helen; Teevan, Kate; Carey, Sharon; Strasser, Simone; Shackel, Nicholas

    2016-03-01

    To investigate the prevalence and duration of preprocedural medically ordered fasting during a period of hospitalisation in an Australian population of patients with hepatic cirrhosis or following liver transplantation and to identify potential solutions to reduce fasting times. Protein-energy malnutrition is a common finding in patients with hepatic cirrhosis and can impact significantly on survival and quality of life. Protein and energy requirements in patients with cirrhosis are higher than those of healthy individuals. A significant feature of cirrhosis is the induction of starvation metabolism following seven to eight hours of food deprivation. Many investigative and interventional procedures for patients with cirrhosis necessitate a period of fasting to comply with anaesthesia guidelines. An observational study of the fasting episodes for 34 hospitalised patients with hepatic cirrhosis or following liver transplantation. Nutritional status was estimated using subjective global assessment and handgrip strength. The prevalence and duration of fasting practices for diagnostic or investigational procedures were estimated using electronic records and patient notes. Thirty-three patients (97%) were malnourished. Twenty-two patients (65%) were fasted during the observation period. There were 43 occasions of fasting with a median fasting time of 13·5 hours. On 40 occasions fasting times exceeded the maximum six-hour guideline recommended prior to the administration of anaesthesia by the majority of Anaesthesiology Societies. The majority of procedures (77%) requiring fasting occurred after midday. Eating breakfast on the day of the procedure reduced fasting time by 45%. Medically ordered preprocedural fasting times almost always exceed existing guidelines in this nutritionally compromised group. Adherence to fasting guidelines and eating breakfast before the procedure can reduce fasting times significantly and avoid the potential induction of starvation metabolism

  16. A review of the UK fast reactor programme. March 1977

    International Nuclear Information System (INIS)

    Smith, R.D.

    1977-01-01

    This paper reports on the Fast Reactor Programme of United Kingdom. These are the main lines: Dounreay Fast Reactor; Prototype Fast Reactor; Commercial Fast Reactor; engineering development; materials development; chemical engineering/sodium technology; fast reactor fuel; fuel cycle; safety; reactor performance study

  17. Fast Physics Testbed for the FASTER Project

    Energy Technology Data Exchange (ETDEWEB)

    Lin, W.; Liu, Y.; Hogan, R.; Neggers, R.; Jensen, M.; Fridlind, A.; Lin, Y.; Wolf, A.

    2010-03-15

    This poster describes the Fast Physics Testbed for the new FAst-physics System Testbed and Research (FASTER) project. The overall objective is to provide a convenient and comprehensive platform for fast turn-around model evaluation against ARM observations and to facilitate development of parameterizations for cloud-related fast processes represented in global climate models. The testbed features three major components: a single column model (SCM) testbed, an NWP-Testbed, and high-resolution modeling (HRM). The web-based SCM-Testbed features multiple SCMs from major climate modeling centers and aims to maximize the potential of SCM approach to enhance and accelerate the evaluation and improvement of fast physics parameterizations through continuous evaluation of existing and evolving models against historical as well as new/improved ARM and other complementary measurements. The NWP-Testbed aims to capitalize on the large pool of operational numerical weather prediction products. Continuous evaluations of NWP forecasts against observations at ARM sites are carried out to systematically identify the biases and skills of physical parameterizations under all weather conditions. The highresolution modeling (HRM) activities aim to simulate the fast processes at high resolution to aid in the understanding of the fast processes and their parameterizations. A four-tier HRM framework is established to augment the SCM- and NWP-Testbeds towards eventual improvement of the parameterizations.

  18. Power from plutonium: fast reactor fuel

    International Nuclear Information System (INIS)

    Bishop, J.F.W.

    1981-01-01

    Points of similarity and of difference between fast reactor fuel and fuels for AGR and PWR plants are established. The flow of uranium and plutonium in fast and thermal systems is also mentioned, establishing the role of the fast reactor as a plutonium burner. A historical perspective of fast reactors is given in which the substantial experience accumulated in test and prototype is indicated and it is noted that fast reactors have now entered the commercial phase. The relevance of the data obtained in the test and prototype reactors to the behaviour of commercial fast reactor fuel is considered. The design concepts employed in fuel are reviewed, including sections on core support styles, pin support and pin detail. This is followed by a discussion of current issues under the headings of manufacture, performance and reprocessing. This section includes a consideration of gel fuel, achievable burn-up, irradiation induced distortions and material choices, fuel form, and fuel failure mechanisms. Future development possibilities are also discussed and the Paper concludes with a view on the logic of a UK fast reactor strategy. (U.K.)

  19. The energy gap and the fast reactor

    International Nuclear Information System (INIS)

    Hill, J.

    1977-01-01

    The background to the development of fast reactors is summarized. In Britain, the results of the many experiments performed, the operation of the Dounreay Fast Reactor for the past 18 years and the first year's operation of the larger Prototype Fast Reactor have all been very encouraging, in that they demonstrated that the performance corresponded well with predictions, breeding is possible, and the system is exceptionally stable in operation. The next step in fast reactor engineering is to build a full-scale fast reactor power station. There would seem to be little reason to expect more trouble than could reasonably be expected in constructing any large project of this general nature. However, from an engineering point of view continuity of experience is required. If a decision to build a commercial fast reactor were taken today there would be a 14-year gap between strating this and the start of the Prototype Fast Reactor. This is already much too long. From an environmental standpoint we have to demonstrate that we can manufacture and reprocess fast reacctor fuel for a substantial programme in a way that does not lead to pollution of the environment, and that plutonium-containing fuel can be transported in the quantities required in safety and in a way that does not attract terrorists or require a private army to ensure its security. Finally, we have to find a way to allow many countries to obtain the energy they need from fast reactors, without leading to the proliferation of nuclear weapons or weapons capability. (author)

  20. Fast reactor fuel reprocessing in the UK

    International Nuclear Information System (INIS)

    Allardice, R.H.; Williams, J.; Buck, C.

    1977-01-01

    Enriched uranium metal fuel irradiated in the Dounreay Fast Reactor has been reprocessed and refabricated in plants specifically designed for the purpose in the U.K. since 1961. Efficient and reliable fuel recycle is essential to the development of a plutonium based fast reactor system and the importance of establishing at an early stage fast reactor fuel reprocessing has been reinforced by current world difficulties in reprocessing high burn-up thermal reactor oxide fuel. In consequence, the U.K. has decided to reprocess irradiated fuel from the 250 MW(E) Prototype Fast Reactor as an integral part of the fast reactor development programme. Flowsheet and equipment development work for the small scale fully active demonstration plant have been carried out over the past 5 years and the plant will be commissioned and ready for active operation during 1977. In parallel, a comprehensive waste management system has been developed and installed. Based on this development work and the information which will arise from active operation of the plant a parallel development programme has been initiated to provide the basis for the design of a large scale fast reactor fuel reprocessing plant to come into operation in the late 1980s to support the projected U.K. fast reactor installation programme. The paper identifies the important differences between fast reactor and thermal reactor fuel reprocessing technologies and describes some of the development work carried out in these areas for the small scale P.F.R. fuel reprocessing operation. In addition, the development programme in aid of the design of a larger scale fast reactor fuel reprocessing plant is outlined and the current design philosophy is discussed

  1. Some questions and answers concerning fast reactors

    International Nuclear Information System (INIS)

    Marshall, W.

    1980-01-01

    The theme of the lecture is the place of the fast reactor in an evolving nuclear programme. The whole question of plutonium is first considered, ie its method of production and the ways in which it can be used in the fast reactor fuel cycle. Whether fast reactors are necessary is then discussed. Their safety is examined with particular attention to those design features which are most criticised ie high volumetric power density of the core, and the use of liquid sodium as coolant. Attention is then paid to environmental and safeguard aspects. (U.K.)

  2. Fast breeder reactors--lecture 4

    International Nuclear Information System (INIS)

    Marshall, W.; Davies, L.M.

    1986-01-01

    This paper discusses the economics of fast breeder reactors. An algebraic background is presented which represents the various views expressed by different nations regarding the cost of fast breeder reactors and their associated fuel cycle services, the timescale by which they might be available, and the simultaneous variations in the price of uranium. Actual presentations made by individual countries in recent discussions serve to verify the general nature of this present discussion. It is assumed that if nuclear power is to make a long term contribution to the needs of the world, the introduction of fast breeder reactors is both essential and necessary

  3. Fast plunges into Kerr black holes

    Energy Technology Data Exchange (ETDEWEB)

    Hadar, Shahar [Racah Institute of Physics, Hebrew University,Jerusalem 91904 (Israel); Porfyriadis, Achilleas P.; Strominger, Andrew [Center for the Fundamental Laws of Nature, Harvard University,Cambridge, MA 02138 (United States)

    2015-07-15

    Most extreme-mass-ratio-inspirals of small compact objects into supermassive black holes end with a fast plunge from an eccentric last stable orbit. For rapidly rotating black holes such fast plunges may be studied in the context of the Kerr/CFT correspondence because they occur in the near-horizon region where dynamics are governed by the infinite dimensional conformal symmetry. In this paper we use conformal transformations to analytically solve for the radiation emitted from fast plunges into near-extreme Kerr black holes. We find perfect agreement between the gravity and CFT computations.

  4. Euratom contributions in Fast Reactor research programmes

    International Nuclear Information System (INIS)

    Fanghänel, Th.; Somers, J.

    2013-01-01

    The Sustainable Nuclear Initiative: • demonstrate long-term sustainability of nuclear energy; • demonstration reactors of Gen IV: •more efficient use of resources; • closed fuel cycle; • reduced proliferation risks; • enhanced safety features. • Systems pursued in Europe: • Sodium-cooled fast reactor SFR; • Lead-cooled fast reactor LFR; • Gas-cooled fast reactor GFR. Sustainable Nuclear Energy Technology Platform SNE-TP promotes research, development and demonstration of the nuclear fission technologies necessary to achieve the SET-Plan goals

  5. Fast-track revision knee arthroplasty

    DEFF Research Database (Denmark)

    Husted, Henrik; Otte, Niels Kristian Stahl; Kristensen, Billy B

    2011-01-01

    Abstract Background and purpose Fast-track surgery has reduced the length of hospital stay (LOS), morbidity, and convalescence in primary hip and knee arthroplasty (TKA). We assessed whether patients undergoing revision TKA for non-septic indications might also benefit from fast-track surgery....... Methods 29 patients were operated with 30 revision arthroplasties. Median age was 67 (34-84) years. All patients followed a standardized fast-track set-up designed for primary TKA. We determined the outcome regarding LOS, morbidity, mortality, and satisfaction. Results Median LOS was 2 (1-4) days...

  6. The fast debris evolution model

    Science.gov (United States)

    Lewis, H. G.; Swinerd, G. G.; Newland, R. J.; Saunders, A.

    2009-09-01

    The 'particles-in-a-box' (PIB) model introduced by Talent [Talent, D.L. Analytic model for orbital debris environmental management. J. Spacecraft Rocket, 29 (4), 508-513, 1992.] removed the need for computer-intensive Monte Carlo simulation to predict the gross characteristics of an evolving debris environment. The PIB model was described using a differential equation that allows the stability of the low Earth orbit (LEO) environment to be tested by a straightforward analysis of the equation's coefficients. As part of an ongoing research effort to investigate more efficient approaches to evolutionary modelling and to develop a suite of educational tools, a new PIB model has been developed. The model, entitled Fast Debris Evolution (FADE), employs a first-order differential equation to describe the rate at which new objects ⩾10 cm are added and removed from the environment. Whilst Talent [Talent, D.L. Analytic model for orbital debris environmental management. J. Spacecraft Rocket, 29 (4), 508-513, 1992.] based the collision theory for the PIB approach on collisions between gas particles and adopted specific values for the parameters of the model from a number of references, the form and coefficients of the FADE model equations can be inferred from the outputs of future projections produced by high-fidelity models, such as the DAMAGE model. The FADE model has been implemented as a client-side, web-based service using JavaScript embedded within a HTML document. Due to the simple nature of the algorithm, FADE can deliver the results of future projections immediately in a graphical format, with complete user-control over key simulation parameters. Historical and future projections for the ⩾10 cm LEO debris environment under a variety of different scenarios are possible, including business as usual, no future launches, post-mission disposal and remediation. A selection of results is presented with comparisons with predictions made using the DAMAGE environment model

  7. The Adverse Effects and Treatment Results of Smoking Cessation Pharmacotherapy During Fasting/Non-Fasting State.

    Science.gov (United States)

    Iliaz, Sinem; Tural Onur, Seda; Uysal, Mehmet Atilla; Chousein, Efsun Gonca Uğur; Tanriverdi, Elif; Bagci, Belma Akbaba; Bahadir, Ayse; Hattatoglu, Didem Gorgun; Ortakoylu, Mediha Gonenc; Yurt, Sibel

    2017-07-03

    Cigarette smoking is one of the most common addictions worldwide. Muslim smokers reduce the number of cigarettes they smoke during Ramadan due to the long fasting hours. We aimed to share our experience in a smoking cessation clinic during Ramadan by analyzing the efficacy and adverse effects of once-daily dosing of bupropion or varenicline in a fasting group compared with conventional dosing in a non-fasting group. We analyzed 57 patients who attended our smoking cessation clinic during Ramadan of 2014 and 2015, and at least one follow-up visit. For the fasting patients, we prescribed bupropion or varenicline after dinner (once daily) as the maintenance therapy. We recorded demographic characteristics of the patients, fasting state, drugs taken for smoking cessation, and the dosage of the medication. At the first follow-up visit, adverse effects seen with the treatment were recorded. We conducted telephone interviews 6 months after the first visits of the patients to learn the current smoking status of the groups. Of the total 57 patients, 20 (35.1%) were fasting and 37 (64.9%) were not fasting. Fasting and non-fasting patients were similar for sex, age, smoking pack-years, marital status, educational status, and mean Fagerström scores (p >.05). Adverse effects and quit rates after 6 months of follow-up were similar between the fasting and non-fasting groups (p >.05). Although our sample size was small, we found no difference in the rates of adverse effects or smoking cessation using a single daily oral dose of bupropion or varenicline between a fasting group and a non-fasting group that received conventional dosing.

  8. Determinants of fast food consumption in Kampala, Uganda | Ayo ...

    African Journals Online (AJOL)

    Consumption of fast-food in Uganda is becoming an increasingly important ... to study the consumption and expenditure behaviour of consumers of fast-food in ... to restaurant negatively influenced the probability of fast-food consumption and ...

  9. Fast Food Combos Make Type A Lunches

    Science.gov (United States)

    Stashower, Gloria

    1974-01-01

    Clark County school district in Las Vegas, Nevada, has combination lunches available for high school students that meet Type A nutrition requirements but which resemble the commercial fast food menus teenagers prefer. (MLF)

  10. 400 Area/Fast Flux Test Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The 400 Area at Hanford is home primarily to the Fast Flux Test Facility (FFTF), a DOE-owned, formerly operating, 400-megawatt (thermal) liquid-metal (sodium)-cooled...

  11. The fast reactor and energy supply

    International Nuclear Information System (INIS)

    1979-01-01

    The progress made with fast reactor development in many countries is summarised showing that the aim is to provide to the nation concerned an ability to instal fast reactor power stations at the end of this century or early in the next one. Accepting the importance of fast reactors as a potential independent source of energy, problems concerning economics, industrial capability, technical factors, public acceptibility and in particular plutonium management, are discussed. It is concluded that although fast reactors have reached a comparatively advanced stage of development, a number of factors make it likely that their introduction for electricity generation will be a gradual process. Nevertheless it is necessary to complete demonstration and development phases in good time. (U.K.)

  12. THE RAMADAN FAST AND THE DIABETIC PATIENT

    African Journals Online (AJOL)

    ill .. :).' A diabetic patient could fall into this category; if he wishes to fast, therefore, several important criteria have to be met. ... Diabetes-Endocrine Unit, University ofNatal, Durban ... the effects such foods could have on diabetics control.

  13. FastStats: A to Z

    Science.gov (United States)

    ... Women’s Health State and Territorial Data Reproductive Health Contraceptive Use Infertility Reproductive Health Notice Regarding FastStats Mobile ... Access to Health Care Accidents/Unintentional Injuries ADHD Adolescent Health Adult Day Services Centers AIDS/HIV Alcohol ...

  14. White adipose tissue coloring by intermittent fasting.

    Science.gov (United States)

    Kivelä, Riikka; Alitalo, Kari

    2017-11-01

    Intermittent fasting (IF) has been shown to promote metabolic health in several organisms. Two recent papers show that IF induces white adipose tissue beiging and increases thermogenesis, which improves metabolic health in mice.

  15. FastBit: Interactively Searching Massive Data

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Kesheng; Ahern, Sean; Bethel, E. Wes; Chen, Jacqueline; Childs, Hank; Cormier-Michel, Estelle; Geddes, Cameron; Gu, Junmin; Hagen, Hans; Hamann, Bernd; Koegler, Wendy; Lauret, Jerome; Meredith, Jeremy; Messmer, Peter; Otoo, Ekow; Perevoztchikov, Victor; Poskanzer, Arthur; Prabhat,; Rubel, Oliver; Shoshani, Arie; Sim, Alexander; Stockinger, Kurt; Weber, Gunther; Zhang, Wei-Ming

    2009-06-23

    As scientific instruments and computer simulations produce more and more data, the task of locating the essential information to gain insight becomes increasingly difficult. FastBit is an efficient software tool to address this challenge. In this article, we present a summary of the key underlying technologies, namely bitmap compression, encoding, and binning. Together these techniques enable FastBit to answer structured (SQL) queries orders of magnitude faster than popular database systems. To illustrate how FastBit is used in applications, we present three examples involving a high-energy physics experiment, a combustion simulation, and an accelerator simulation. In each case, FastBit significantly reduces the response time and enables interactive exploration on terabytes of data.

  16. Fast Exact Euclidean Distance (FEED) Transformation

    NARCIS (Netherlands)

    Schouten, Theo; Kittler, J.; van den Broek, Egon; Petrou, M.; Nixon, M.

    2004-01-01

    Fast Exact Euclidean Distance (FEED) transformation is introduced, starting from the inverse of the distance transformation. The prohibitive computational cost of a naive implementation of traditional Euclidean Distance Transformation, is tackled by three operations: restriction of both the number

  17. Islamic fasting and oral health and diseases

    Directory of Open Access Journals (Sweden)

    A Javadzadeh Blouri

    2014-12-01

    Full Text Available Fasting is a religious obligation, which can be challenging for individuals with oral conditions due to its stringent code of conduct. Moreover, food abstinence during fasting can restrict oral feeding even further in patients whose nutrition has been already compromised. Previous research has mainly concentrated on oral hygiene and gum health, disregarding orodental conditions and diseases. This highlights the importance of further research in this regard. In this paper, we intended to clarify the correlation between fasting and oral injections, bleeding following tooth extraction, and brushing to overcome common misconceptions which indicate the breach of religious disciplines under such circumstances. We also aimed to determine the grave effects of fasting on health in case of severe immunological deficiencies, chronic oral ulcers and certain drug administration protocols for those with rigid religious beliefs.

  18. Relationship between glycated haemoglobin and fasting plasma ...

    African Journals Online (AJOL)

    Emmanuel Musenge

    2016-07-30

    Jul 30, 2016 ... Relationship between glycated haemoglobin and fasting plasma glucose ... major stakeholders in the management of diabetes mellitus to consider FPG as an ..... HbA1c among customers of health examination services.

  19. Waves from Propulsion Systems of Fast Ferries

    DEFF Research Database (Denmark)

    Taatø, Søren Haugsted; Aage, Christian; Arnskov, Michael M.

    1998-01-01

    Waves from fast ferries have become an environmental problem of growing concern to the public. Fast ferries produce not only higher waves than conventional ships but also fundamentally different wave systems when they sail at supercritical speeds. Hitherto, ship waves have been considered as being...... generated by the ship hulls alone. Whereas this assumption may be reasonable for conventional ships with large hulls and limited propulsive power, the situation is different for fast ferries with their smaller hulls and very large installed power. A simple theoretical model and a series of model tests...... on a monohull fast ferry seem to indicate that a substantial part of the wave-making can be directly attributed to the propulsion system itself. Thus, two wave systems are created with different phases, but with similar frequency contents, which means that they merge into one system behind the ship, very...

  20. Upgrading the Fast Calorimeter Simulation in ATLAS

    CERN Document Server

    Schaarschmidt, Jana; The ATLAS collaboration

    2017-01-01

    The tremendous need for simulated samples now and even more so in the future, encourage the development of fast simulation techniques. The Fast Calorimeter Simulation is a faster though less accurate alternative to the full calorimeter simulation with Geant4. It is based on parametrizing the longitudunal and lateral energy deposits of single particles in the ATLAS calorimeter. Principal component analysis and machine learning techniques are used to improve the performance and decrease the memory need compared to the current version of the ATLAS Fast Calorimeter Simulation. The parametrizations are expanded to cover very high energies and very forward detector regions, to increase the applicability of the tool. A prototype of this upgraded Fast Calorimeter Simulation has been developed and first validations with single particles show substantial improvements over the previous version.

  1. Design codes for fast reactor steam generators

    International Nuclear Information System (INIS)

    Townley, C.H.A.

    1978-01-01

    The paper reviews the design methods and design criteria which are available for fast reactor structures, and discusses the materials data which are required to demonstrate the integrity of the plant components. (author)

  2. Fast reactor fuel design and development

    International Nuclear Information System (INIS)

    Bishop, J.F.W.; Chamberlain, A.; Holmes, J.A.G.

    1977-01-01

    Fuel design parameters for oxide and carbide fast reactor fuels are reviewed in the context of minimising the total uranium demands for a combined thermal and fast reactor system. The major physical phenomena conditioning fast reactor fuel design, with a target of high burn-up, good breeding and reliable operation, are characterised. These include neutron induced void swelling, irradiation creep, pin failure modes, sub-assembly structural behaviour, behaviour of defect fuel, behaviour of alternative fuel forms. The salient considerations in the commercial scale fabrication and reprocessing of the fuels are reviewed, leading to the delineation of possible routes for the manufacture and reprocessing of Commercial Reactor fuel. From the desiderata and restraints arising from Surveys, Performance and Manufacture, the problems posed to the Designer are considered, and a narrow range of design alternatives is proposed. The paper concludes with a consideration of the development areas and the conceptual problems for fast reactors associated with those areas

  3. Fast ion loss diagnostic plans for NSTX

    International Nuclear Information System (INIS)

    Darrow, D. S.; Bell, R.; Johnson, R.; Kugel, H.; Wilson, J. R.; Cecil, F. E.; Maingi, R.; Krasilnikov, A.; Alekseyev, A.

    2000-01-01

    The prompt loss of neutral beam ions from the National Spherical Torus Experiment (NSTX) is expected to be between 12% and 42% of the total 5 MW of beam power. There may, in addition, be losses of fast ions arising from high harmonic fast wave (HHFW) heating. Most of the lost ions will strike the HHFW antenna or the neutral beam dump. To measure these losses in the 2000 experimental campaign, thermocouples in the antenna, several infrared camera views, and a Faraday cup lost ion probe will be employed. The probe will measure loss of fast ions with E > 1 keV at three radial locations, giving the scrape-off length of the fast ions

  4. Safeguards challenges of Fast Breeder Reactor

    International Nuclear Information System (INIS)

    Ko, H. S.

    2010-01-01

    Although the safeguards system of Sodium Fast Reactor (SFR) seems similar to that of Light Water Reactor (LWR), it was raised safeguards challenges of SFR that resulted from the visual opacity of liquid sodium, chemical reactivity of sodium and other characteristics of fast reactor. As it is the basic concept stage of the safeguards of SFR in Korea, this study tried to analyze the latest similar study of safeguards issues of the Fast Breeder Reactor (FBR) at Joyo and Monju in Japan. For this reason, this study is to introduce some potential safeguards challenges of Fast Breeder Reactor. With this analysis, future study could be to address the safeguards challenges of SFR in Korea

  5. Slow and Fast Light, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — In response to the NASA Small Business Innovation Research (SBIR) Program 2015 Phase I Solicitation S3.08: Slow and Fast Light, Torch Technologies in partnership...

  6. (LH) secretion in fasted prepubertal ewes

    African Journals Online (AJOL)

    DR. NJ TONUKARI

    2012-01-10

    Jan 10, 2012 ... decreased luteinizing hormone (LH) secretion in fasted prepubertal ewes .... kisspeptin-10 injection could restore the baseline levels of. LH changed by ..... Terasawa E (2005). Role of GABA in the mechanism of the onset of.

  7. Nonfasting Versus Initial Fasting Ketogenic Diet

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2005-02-01

    Full Text Available A retrospective evaluation of the ketogenic diet (KD was conducted comparing efficacy and tolerability of the diet with or without initial fasting and fluid restriction and involving university centers in Seoul, Korea.

  8. FastStats: Illegal Drug Use

    Science.gov (United States)

    ... Contraceptive Use Infertility Reproductive Health Notice Regarding FastStats Mobile Application Get Email Updates To receive email updates ... for Alcohol and Drug Information National Center on Addiction and Substance Abuse (CASA) Get Email Updates To ...

  9. Economic evaluation of fast reactor fuel cycling

    International Nuclear Information System (INIS)

    Hu Ping; Zhao Fuyu; Yan Zhou; Li Chong

    2012-01-01

    Economic calculation and analysis of two kinds of nuclear fuel cycle are conducted by check off method, based on the nuclear fuel cycling process and model for fast reactor power plant, and comparison is carried out for the economy of fast reactor fuel cycle and PWR once-through fuel cycle. Calculated based on the current price level, the economy of PWR one-through fuel cycle is better than that of the fast reactor fuel cycle. However, in the long term considering the rising of the natural uranium's price and the development of the post treatment technology for nuclear fuels, the cost of the fast reactor fuel cycle is expected to match or lower than that of the PWR once-through fuel cycle. (authors)

  10. Direct reading fast microwave interferometer for EBT

    International Nuclear Information System (INIS)

    Uckan, T.

    1984-10-01

    A simple and inexpensive 4-mm direct reading fast (rise time approx. 100 μs) microwave interferometer is described. The system is particularly useful for density measurements on the ELMO Bumpy Torus (EBT) during pulsed operation

  11. Multichannel scaler with fast channel advance

    International Nuclear Information System (INIS)

    Murphy, D.M.

    1985-01-01

    A multichannel scaler has been constructed which is capable of running as fast as 250 ns per channel. It is compact, low power and requires no special construction techniques. Readout is into a memory accessible by a microprocessor. (orig.)

  12. Sociodemographic differences in fast food price sensitivity

    Science.gov (United States)

    Meyer, Katie A.; Guilkey, David K.; Ng, Shu Wen; Duffey, Kiyah J.; Popkin, Barry M.; Kiefe, Catarina I.; Steffen, Lyn M.; Shikany, James M.; Gordon-Larsen, Penny

    2014-01-01

    Importance Fiscal food policies (e.g., taxation) are increasingly proposed to improve population-level health, but their impact on health disparities is unknown. Objective We estimated subgroup-specific effects of fast food price changes on fast food consumption and cardio-metabolic outcomes, hypothesizing inverse associations between fast food price with fast food consumption, BMI, and insulin resistance and stronger associations among blacks (vs. whites) and participants with relatively lower education or income. Design 20-year follow-up (5 exams) in a biracial U.S. prospective cohort: Coronary Artery Risk Development in Young Adults (CARDIA) (1985/86–2005/06, baseline n=5,115). Participants Aged 18–30 at baseline; designed for equal recruitment by race (black/white), educational attainment, age, and gender. Exposures Community-level price data from the Council for Community and Economic Research (C2ER) temporally- and geographically-linked to study participants’ home address at each exam. Main outcome and measures Participant-reported number of fast food eating occasions per week; BMI (kg/m2) from clinical assessment of weight and height; homeostatic model assessment insulin resistance (HOMA-IR) from fasting glucose and insulin. Covariates included individual- and community-level social and demographic factors. Results In repeated measures regression, multivariable-adjusted associations between fast food price and consumption were non-linear (quadratic, pconsumption at higher prices; estimates varied according to race (interaction term p=0.04), income (p=0.07), and education (p=0.03). For example, at the 10th percentile of price ($1.25/serving), blacks and whites had mean fast food consumption (times/week) of 2.2 (95% CI: 2.1–2.3) and 1.6 (1.5–1.7), respectively, while at the 90th percentile of price ($1.53/serving), respective mean consumption estimates were 1.9 (1.8–2.0) and 1.5 (1.4–1.6). We observed differential price effects on HOMA

  13. Fast decoding algorithms for geometric coded apertures

    International Nuclear Information System (INIS)

    Byard, Kevin

    2015-01-01

    Fast decoding algorithms are described for the class of coded aperture designs known as geometric coded apertures which were introduced by Gourlay and Stephen. When compared to the direct decoding method, the algorithms significantly reduce the number of calculations required when performing the decoding for these apertures and hence speed up the decoding process. Experimental tests confirm the efficacy of these fast algorithms, demonstrating a speed up of approximately two to three orders of magnitude over direct decoding.

  14. Transmutation of Americium in Fast Neutron Facilities

    OpenAIRE

    Zhang, Youpeng

    2011-01-01

    In this thesis, the feasibility to use a medium sized sodium cooled fast reactor fully loaded with MOX fuel for efficient transmutation of americium is investigated by simulating the safety performance of a BN600-type fast reactor loaded with different fractions of americium in the fuel, using the safety parameters obtained with the SERPENT Monte Carlo code. The focus is on americium mainly due to its long-term contribution to the radiotoxicity of spent nuclear fuel and its deterioration on c...

  15. Differential staining of bacteria: acid fast stain.

    Science.gov (United States)

    Reynolds, Jackie; Moyes, Rita B; Breakwell, Donald P

    2009-11-01

    Acid-fastness is an uncommon characteristic shared by the genera Mycobacterium (Section 10A) and Nocardia. Because of this feature, this stain is extremely helpful in identification of these bacteria. Although Gram positive, acid-fast bacteria do not take the crystal violet into the wall well, appearing very light purple rather than the deep purple of normal Gram-positive bacteria. (c) 2009 by John Wiley & Sons, Inc.

  16. Effects of Ramadan Fasting on Stroke

    OpenAIRE

    ÇOMOĞLU, Selçuk; TEMİZHAN, Ahmet; PEŞİNCİ, Emel; TANDOĞAN, İzzet; ÖZBAKIR, Şenay

    2014-01-01

    The effects of fasting on humans have not been adequately investigated. Ramadan fasting is a great opportunity for scientific research due to its peculiar nature. With this in mind, we conducted research on the effects of Ramadan on stroke, which is one of the most common causes of death in adults. Patients hospitalized solely for ischemic stroke and intracerebral hemorrhage were evaluated retrospectively. The ratio of these cases to other patients hospitalized in the neurology department w...

  17. Personal Factors and Fast Food Consumption

    OpenAIRE

    Saraniya Devendra

    2016-01-01

    Asian peoples including Sri Lankans are generally fond of cooking food items in their homes. It is understandable that on the other hand, growing knowledge and adoption of western culture bring a modification in food consumption pattern among Sri Lankan families who lives in a particular city area. As such, it is useful to identify the Personal Factors (PF) that influence on Fast Food Consumption (FFC), since the Sri Lankans change their behavior to have fast foods of developed countries from...

  18. Decommissioning of fast reactors after sodium draining

    International Nuclear Information System (INIS)

    2009-11-01

    Acknowledging the importance of passing on knowledge and experience, as well mentoring the next generation of scientists and engineers, and in response to expressed needs by Member States, the IAEA has undertaken concrete steps towards the implementation of a fast reactor data retrieval and knowledge preservation initiative. Decommissioning of fast reactors and other sodium bearing facilities is a domain in which considerable experience has been accumulated. Within the framework and drawing on the wide expertise of the Technical Working Group on Fast Reactors (TWG-FR), the IAEA has initiated activities aiming at preserving the feedback (lessons learned) from this experience and condensing those to technical recommendations on fast reactor design features that would ease their decommissioning. Following a recommendation by the TWG-FR, the IAEA had convened a topical Technical Meeting (TM) on 'Operational and Decommissioning Experience with Fast Reactors', hosted by CEA, Centre d'Etudes de Cadarache, France, from 11 to 15 March 2002 (IAEA-TECDOC- 1405). The participants in that TM exchanged detailed technical information on fast reactor operation and decommissioning experience with various sodium cooled fast reactors, and, in particular, reviewed the status of the various decommissioning programmes. The TM concluded that the decommissioning of fast reactors to reach safe enclosure presented no major difficulties, and that this had been accomplished mainly through judicious adaptation of processes and procedures implemented during the reactor operation phase, and the development of safe sodium waste treatment processes. However, the TM also concluded that, on the path to achieving total dismantling, challenges remain with regard to the decommissioning of components after sodium draining, and suggested that a follow-on TM be convened, that would provide a forum for in-depth scientific and technical exchange on this topic. This publication constitutes the Proceedings of

  19. Universal Fast Breeder Reactor Subassembly Counter manual

    International Nuclear Information System (INIS)

    Menlove, H.O.; Eccleston, G.W.; Swansen, J.E.; Goris, P.; Abedin-Zadeh, R.; Ramalho, A.

    1984-08-01

    A neutron coincidence counter has been designed for the measurement of fast breeder reactor fuel assemblies. This assay system can accommodate the full range of geometries and masses found in fast breeder subassemblies under IAEA safeguards. The system's high-performance capability accommodates high plutonium loadings of up to 16 kg. This manual describes the system and its operation and gives performance and calibration parameters for typical applications

  20. Go Natural : a new fast food concept

    OpenAIRE

    Coelho, João Miguel Rodrigues

    2013-01-01

    Go Natural is a 100% Portuguese healthy fast food chain that was created by two siblings’ entrepreneurs, Diogo and Joana Martorell, whom had the wish to make something different. This company was chosen to serve as the setting of a Teaching Marketing study, with the purpose of being used as a pedagogical tool in undergraduate programs. This case provides students the opportunity to become familiar with brand expansions and the fast food market. In 2004, this pioneer brand provi...