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Sample records for nonresilient counterparts chronic

  1. Chronic Lymphocytic Leukemia B-Cell Normal Cellular Counterpart: Clues From a Functional Perspective.

    Science.gov (United States)

    Darwiche, Walaa; Gubler, Brigitte; Marolleau, Jean-Pierre; Ghamlouch, Hussein

    2018-01-01

    Chronic lymphocytic leukemia (CLL) is characterized by the clonal expansion of small mature-looking CD19+ CD23+ CD5+ B-cells that accumulate in the blood, bone marrow, and lymphoid organs. To date, no consensus has been reached concerning the normal cellular counterpart of CLL B-cells and several B-cell types have been proposed. CLL B-cells have remarkable phenotypic and gene expression profile homogeneity. In recent years, the molecular and cellular biology of CLL has been enriched by seminal insights that are leading to a better understanding of the natural history of the disease. Immunophenotypic and molecular approaches (including immunoglobulin heavy-chain variable gene mutational status, transcriptional and epigenetic profiling) comparing the normal B-cell subset and CLL B-cells provide some new insights into the normal cellular counterpart. Functional characteristics (including activation requirements and propensity for plasma cell differentiation) of CLL B-cells have now been investigated for 50 years. B-cell subsets differ substantially in terms of their functional features. Analysis of shared functional characteristics may reveal similarities between normal B-cell subsets and CLL B-cells, allowing speculative assignment of a normal cellular counterpart for CLL B-cells. In this review, we summarize current data regarding peripheral B-cell differentiation and human B-cell subsets and suggest possibilities for a normal cellular counterpart based on the functional characteristics of CLL B-cells. However, a definitive normal cellular counterpart cannot be attributed on the basis of the available data. We discuss the functional characteristics required for a cell to be logically considered to be the normal counterpart of CLL B-cells.

  2. The geomorphology of wetlands in drylands: Resilience, nonresilience, or …?

    Science.gov (United States)

    Tooth, Stephen

    2018-03-01

    Over the last decade, much attention has focused on wetland resilience to disturbances such as extreme weather events, longer climate change, and human activities. In geomorphology and cognate disciplines, resilience is defined in various ways and has physical and socioeconomic dimensions but commonly is taken to mean the ability of a system to (A) withstand disturbance, (B) recover from disturbance, or (C) adapt and evolve in response to disturbance to a more desirable (e.g., stable) configuration. Most studies of wetland resilience have tended to focus on the more-or-less permanently saturated humid region wetlands, but whether the findings can be readily transferred to wetlands in drylands remains unclear. Given the natural climatic variability and overall strong moisture deficit characteristic of drylands, are such wetlands likely to be more resilient or less resilient? Focusing on wetlands in the South African drylands, this paper uses existing geomorphological, sedimentological, and geochronological data sets to provide the spatial (up to 50 km2) and temporal (late Quaternary) framework for an assessment of geomorphological resilience. Some wetlands have been highly resilient to environmental (especially climate) change, but others have been nonresilient with marked transformations in channel-floodplain structure and process connectivity having been driven by natural factors (e.g., local base-level fall, drought) or human activities (e.g., channel excavation, floodplain drainage). Key issues related to the assessment of wetland resilience include channel-floodplain dynamics in relation to geomorphological thresholds, wetland geomorphological 'life cycles', and the relative roles of natural and human activities. These issues raise challenges for the involvement of geomorphologists in the practical application of the resilience concept in wetland management. A key consideration is how geomorphological resilience interfaces with other dimensions of resilience

  3. When Violence Can Appear With Different Male Partners: Identification of Resilient and Non-resilient Women in the European Union

    Directory of Open Access Journals (Sweden)

    Juan Herrero

    2018-06-01

    Full Text Available Introduction: Little scholarly attention has been paid to the analysis of the history of intimate partner violence (IPV against women with different male partners and how it could be related to levels of IPV with the current male partner. From this point of view, been a victim of IPV could increase the vulnerability of women and, therefore, exert a negative influence on the selection of partners over time, thus increasing the odds of potentially mating with abusive male partners. Alternatively, for some women victims of IPV in previous relationships, there may be additional resources that reduce their vulnerability to victimization by new partners.Methodology: The present study analyzes levels of IPV in different partners of 2376 heterosexual women from the 28 countries of the European Union living together as a couple who had previously lived with a different male partner.Analysis/Discussion: Multilevel regression results indicated that resilient women were younger, more satisfied with household income, and were involved in shorter relationships. As for their previous levels of victimization, they scored lower on child abuse and non-partner adult victimization. Also, their levels of victimization from previous partners were the same as those of the non-resilient women, with the exception of physical IPV victimization where resilient women scored higher than non-resilient women. Resilient women also informed the interviewer to have ended the abusive relationship because of the violence to a greater extent than non-resilient women and seemed to suffer fewer psychological difficulties due to previous violent relationships. Finally, countries scoring higher on human development index (HDI showed a larger proportion of resilient women.Conclusion: Resilient women are mostly characterized by fewer psychological difficulties and lower frequency of adverse situations (in childhood or in adulthood when compared to non-resilient women. Although resilient

  4. ACCOUNTING TREATMENTS SPECIFIC TO COUNTERPART COMMERCIAL TRANSACTIONS

    Directory of Open Access Journals (Sweden)

    Lucia PALIU - POPA

    2010-12-01

    Full Text Available Given the lack of availability of funds in foreign currency, felt in many countries, especially in the developing and developed countries and the economic or financial crisis in the global foreign exchange, counterpart commercial transactions were imposed as a “disarming” condition of the international trade. In the counterpart a purchase transaction is combined with a sale transaction, an import with an export in order to ensure balanced trade between the partners, trade that involves eliminating or reducing the currency as a payment source and its replacement with trade of goods and services. Thus, in the context of an acute need to export of greatly industrialized countries, where the overproduction phenomenon tends to have a chronic character, the counterpart has become a highly complex and sustainable phenomenon, which has seen a steady increase in the volume of amounts, with a geographical area and large variety of forms and mechanisms of implementation. Based on the characteristics and structure of counterpart transactions, we shall describe in this paper the accounting models specific to international trade, as part of the combined foreign trade transactions without neglecting the tax treatments that influence the entry in the accounts

  5. Quantum experiments without classical counterparts

    International Nuclear Information System (INIS)

    Pavicic, M.

    2005-01-01

    Full text: We present a generalized and exhaustive method of finding the directions of the quantization axes of the measured eigenstates within experiments which have no classical counterparts. The method relies on a constructive and exhaustive definition of sets of such directions (which we call Kochen-Specker vectors) in a Hilbert space of any dimension as well as of all the remaining vectors of the space. Kochen-Specker vectors are elements of any set of orthonormal states, i.e., vectors in n-dim Hilbert space, Hn, n > 2 to which it is impossible to assign 1s and 0s in such a way that no two mutually orthogonal vectors from the set are both assigned 1 and that not all mutually orthogonal vectors are assigned 0. Our constructive definition of such Kochen-Specker vectors is based on algorithms that generate MMP diagrams corresponding to blocks of orthogonal vectors in Rn, on algorithms that single out those diagrams on which algebraic to 0-1 states cannot be defined, and on algorithms that solve nonlinear equations describing the orthogonalities of the vectors by means of statistically polynomially complex interval analysis and self-teaching programs. The algorithms are limited neither by the number of dimensions nor by the number of vectors. To demonstrate the power of the algorithms, all 4-dim KS vector systems containing up to 24 vectors were generated and described, all 3-dim vector systems containing up to 30 vectors were scanned, and several general properties of KS vectors were found. (author)

  6. Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

    Science.gov (United States)

    ... and abnormal sensations. CIDP is closely related to Guillain-Barre syndrome and it is considered the chronic counterpart ... and abnormal sensations. CIDP is closely related to Guillain-Barre syndrome and it is considered the chronic counterpart ...

  7. Electromagnetic Counterparts to Black Hole Mergers

    Science.gov (United States)

    Schnittman, Jeremy D.

    2011-01-01

    During the final moments of a binary black hole (BH) merger, the gravitational wave (GW) luminosity of the system is greater than the combined electromagnetic (EM) output of the entire observable universe. However, the extremely weak coupling between GWs and ordinary matter makes these waves very difficult to detect directly. Fortunately, the inspirating BH system will interact strongly-on a purely Newtonian level-with any surrounding material in the host galaxy, and this matter can in turn produce unique EM signals detectable at Earth. By identifying EM counterparts to GW sources, we will be able to study the host environments of the merging BHs, in turn greatly expanding the scientific yield of a mission like LISA. Here we present a comprehensive review of the recent literature on the subject of EM counterparts, as well as a discussion of the theoretical and observational advances required to fully realize the scientific potential of the field.

  8. Biological formal counterparts of logical machines

    Energy Technology Data Exchange (ETDEWEB)

    Moreno-diaz, R; Hernandez Guarch, F

    1983-01-01

    The significance of the McCulloch-Pitts formal neural net theory (1943) is still nowadays frequently misunderstood, and their basic units are wrongly considered as factual models for neurons. As a consequence, the whole original theory and its later addenda are unreasonably criticized for their simplicity. But, as it was proved then and since, the theory is after the modular neurophysiological counterpart of logical machines, so that it actually provides biologically plausible models for automata, turing machines, etc., and not vice versa. In its true context, no theory has surpassed its proposals. In McCulloch and Pitts memoriam and for the sake of future theoretical research, the authors stress this important historical point, including also some recent results on the neurophysiological counterparts of modular arbitrary probabilistic automata. 16 references.

  9. Gamma Ray Bursts-Afterglows and Counterparts

    Science.gov (United States)

    Fishman, Gerald J

    1998-01-01

    Several breakthrough discoveries were made last year of x-ray, optical and radio afterglows and counterparts to gamma-ray bursts, and a redshift has been associated with at least one of these. These discoveries were made possible by the fast, accurate gamma-ray burst locations of the BeppoSAX satellite. It is now generally believed that the burst sources are at cosmological distances and that they represent the most powerful explosions in the Universe. These observations also open new possibilities for the study of early star formation, the physics of extreme conditions and perhaps even cosmology. This session will concentrate on recent x-ray, optical and radio afterglow observations of gamma-ray bursts, associated redshift measurements, and counterpart observations. Several review and theory talks will also be presented, along with a summary of the astrophysical implications of the observations. There will be additional poster contributions on observations of gamma-ray burst source locations at wavelengths other than gamma rays. Posters are also solicited that describe new observational capabilities for rapid follow-up observations of gamma-ray bursts.

  10. Optimizing searches for electromagnetic counterparts of gravitational wave triggers

    Science.gov (United States)

    Coughlin, Michael W.; Tao, Duo; Chan, Man Leong; Chatterjee, Deep; Christensen, Nelson; Ghosh, Shaon; Greco, Giuseppe; Hu, Yiming; Kapadia, Shasvath; Rana, Javed; Salafia, Om Sharan; Stubbs11, Christopher

    2018-04-01

    With the detection of a binary neutron star system and its corresponding electromagnetic counterparts, a new window of transient astronomy has opened. Due to the size of the sky localization regions, which can span hundreds to thousands of square degrees, there are significant benefits to optimizing tilings for these large sky areas. The rich science promised by gravitational-wave astronomy has led to the proposal for a variety of proposed tiling and time allocation schemes, and for the first time, we make a systematic comparison of some of these methods. We find that differences of a factor of 2 or more in efficiency are possible, depending on the algorithm employed. For this reason, with future surveys searching for electromagnetic counterparts, care should be taken when selecting tiling, time allocation, and scheduling algorithms to optimize counterpart detection.

  11. A possible human counterpart of the principle of increasing entropy

    International Nuclear Information System (INIS)

    Liang, Y.; An, K.N.; Yang, G.; Huang, J.P.

    2014-01-01

    It is well-known that the principle of increasing entropy holds for isolated natural systems that contain non-adaptive molecules. Here we present, for the first time, an experimental evidence for a possible human counterpart of the principle in an isolated social system that involves adaptive humans. Our work shows that the human counterpart is valid even though interactions among humans in social systems are distinctly different from those among molecules in natural systems. Thus, it becomes possible to understand social systems from this natural principle, at least to some extent.

  12. Search for infrared counterparts of gamma-ray bursters

    International Nuclear Information System (INIS)

    Schaefer, B.E.; Cline, T.L.

    1985-01-01

    The result of two searches for infrared counterparts of Gamma-ray Bursters (GRB's) is reported. The first search was made using data from the Infrared Astronomy Satellite and covered 23 positions. The second search was made with the Kitt Peak 1.5 m telescope and covered 3 positions. In neither of these two searches was any infrared candidate detected

  13. Continual Lie algebras and noncommutative counterparts of exactly solvable models

    Science.gov (United States)

    Zuevsky, A.

    2004-01-01

    Noncommutative counterparts of exactly solvable models are introduced on the basis of a generalization of Saveliev-Vershik continual Lie algebras. Examples of noncommutative Liouville and sin/h-Gordon equations are given. The simplest soliton solution to the noncommutative sine-Gordon equation is found.

  14. VARIABILITY OF OPTICAL COUNTERPARTS IN THE CHANDRA GALACTIC BULGE SURVEY

    Energy Technology Data Exchange (ETDEWEB)

    Britt, C. T.; Hynes, R. I.; Johnson, C. B.; Baldwin, A.; Collazzi, A.; Gossen, L. [Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA 70803-4001 (United States); Jonker, P. G.; Torres, M. A. P. [SRON, Netherlands Institute for Space Research, Sorbonnelaan 2, 3584 CA Utrecht (Netherlands); Nelemans, G. [Department of Astrophysics, IMAPP, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ, Nijmegen (Netherlands); Maccarone, T. [Department of Physics, Texas Tech University, Box 41051, Science Building, Lubbock, TX 79409-1051 (United States); Steeghs, D.; Greiss, S. [Astronomy and Astrophysics, Department of Physics, University of Warwick, Coventry, CV4 7AL (United Kingdom); Heinke, C. [Department of Physics, University of Alberta, CCIS 4-183, Edmonton, AB T6G 2E1 (Canada); Bassa, C. G. [Jodrell Bank Centre for Astrophysics, School of Physics and Astronomy, University of Manchester, Manchester M13 9PL (United Kingdom); Villar, A. [Department of Physics, Massachussettes Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307 (United States); Gabb, M. [Department of Physics, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431-0991 (United States)

    2014-09-01

    We present optical light curves of variable stars consistent with the positions of X-ray sources identified with the Chandra X-ray Observatory for the Chandra Galactic Bulge Survey (GBS). Using data from the Mosaic-II instrument on the Blanco 4 m Telescope at CTIO, we gathered time-resolved photometric data on timescales from ∼2 hr to 8 days over the 3/4 of the X-ray survey containing sources from the initial GBS catalog. Among the light curve morphologies we identify are flickering in interacting binaries, eclipsing sources, dwarf nova outbursts, ellipsoidal variations, long period variables, spotted stars, and flare stars. Eighty-seven percent of X-ray sources have at least one potential optical counterpart. Twenty-seven percent of these candidate counterparts are detectably variable; a much greater fraction than expected for randomly selected field stars, which suggests that most of these variables are real counterparts. We discuss individual sources of interest, provide variability information on candidate counterparts, and discuss the characteristics of the variable population.

  15. 76 FR 61090 - Endangered and Threatened Species; Counterpart Regulations

    Science.gov (United States)

    2011-10-03

    ..., National Fire Plan Counterpart Regulation Alternative Consultation Agreements (ACAs). DATES: This is effective on October 1, 2011. ADDRESSES: The final decision of revocation is available on the internet at http://www.nmfs.noaa.gov/pr/laws/esa/policies.htm#consultation and http://www.fws.gov/endangered/esa...

  16. Search for Gravitational Wave Counterparts with Fermi GBM

    Science.gov (United States)

    Hui, C. M.

    2017-01-01

    The progenitor of short gamma-ray bursts (GRBs) is believed to be the merger of two compact objects. This type of events will also produce gravitational waves. Since the gravitational waves discovery by LIGO, the search for a joint detection with an electromagnetic counterpart has been ongoing. Fermi GBM detects approximately 40 short GRBs per year, and we have been expanding our search looking for faint events in the GBM data that did not trigger onboard.

  17. Identification of a Likely Radio Counterpart to the Rapid Burster

    Science.gov (United States)

    Moore, Christopher B.; Rutledge, Robert E.; Fox, Derek W.; Guerriero, Robert A.; Lewin, Walter H. G.; Fender, Robert; van Paradijs, Jan

    2000-04-01

    We have identified a likely radio counterpart to the low-mass X-ray binary MXB 1730-335 (the Rapid Burster). The counterpart has shown 8.4 GHz radio on/off behavior correlated with the X-ray on/off behavior as observed by the RXTE/ASM during six VLA observations. The probability of an unrelated, randomly varying background source duplicating this behavior is 1%-3% depending on the correlation timescale. The location of the radio source is R.A. 17h33m24.61s, decl. -33 deg23'19.8" (J2000), +/-0.1". We do not detect 8.4 GHz radio emission coincident with type II (accretion-driven) X-ray bursts. The ratio of radio to X-ray emission during such bursts is constrained to be below the ratio observed during X-ray-persistent emission at the 2.9 σ level. Synchrotron bubble models of the radio emission can provide a reasonable fit to the full data set, collected over several outbursts, assuming that the radio evolution is the same from outburst to outburst but given the physical constraints the emission is more likely to be due to ~1 hr radio flares such as have been observed from the X-ray binary GRS 1915+105.

  18. Negative-strand RNA viruses: the plant-infecting counterparts.

    Science.gov (United States)

    Kormelink, Richard; Garcia, Maria Laura; Goodin, Michael; Sasaya, Takahide; Haenni, Anne-Lise

    2011-12-01

    While a large number of negative-strand (-)RNA viruses infect animals and humans, a relative small number have plants as their primary host. Some of these have been classified within families together with animal/human infecting viruses due to similarities in particle morphology and genome organization, while others have just recently been/or are still classified in floating genera. In most cases, at least two striking differences can still be discerned between the animal/human-infecting viruses and their plant-infecting counterparts which for the latter relate to their adaptation to plants as hosts. The first one is the capacity to modify plasmodesmata to facilitate systemic spread of infectious viral entities throughout the plant host. The second one is the capacity to counteract RNA interference (RNAi, also referred to as RNA silencing), the innate antiviral defence system of plants and insects. In this review an overview will be presented on the negative-strand RNA plant viruses classified within the families Bunyaviridae, Rhabdoviridae, Ophioviridae and floating genera Tenuivirus and Varicosavirus. Genetic differences with the animal-infecting counterparts and their evolutionary descendants will be described in light of the above processes. Copyright © 2011 Elsevier B.V. All rights reserved.

  19. Driving protocol for a Floquet topological phase without static counterpart

    Science.gov (United States)

    Quelle, A.; Weitenberg, C.; Sengstock, K.; Morais Smith, C.

    2017-11-01

    Periodically driven systems play a prominent role in optical lattices. In these ultracold atomic systems, driving is used to create a variety of interesting behaviours, of which an important example is provided by topological states of matter. Such Floquet topological phases have a richer classification than their equilibrium counterparts. Although there exist analogues of the equilibrium topological phases that are characterised by a Chern number, the corresponding Hall conductivity, and protected edge states, there is an additional possibility. This is a phase that has a vanishing Chern number and no Hall conductivity, but nevertheless hosts anomalous topological edge states (Rudner et al (2013 Phys. Rev. X 3 031005)). Due to experimental difficulties associated with the observation of such a phase, it has not been experimentally realised in optical lattices so far. In this paper, we show that optical lattices prove to be a good candidate for its realisation and observation, because they can be driven in a controlled manner. Specifically, we present a simple shaking protocol that serves to realise this special Floquet phase, discuss the specific properties that it has, and propose a method to experimentally detect this fascinating topological phase that has no counterpart in equilibrium systems.

  20. X-ray Counterparts of Infrared Faint Radio Sources

    Science.gov (United States)

    Schartel, Norbert

    2011-10-01

    Infrared Faint Radio Sources (IFRS) are radio sources with extremely faint or even absent infrared emission in deep Spitzer Surveys. Models of their spectral energy distributions, the ratios of radio to infrared flux densities and their steep radio spectra strongly suggest that IFRS are AGN at high redshifts (2IFRS, but if confirmed, the increased AGN numbers at these redshifts will account for the unresolved part of the X-ray background. The identification of X-ray counterparts of IFRS is considered to be the smoking gun for this hypothesis. We propose to observe 8 IFRS using 30ks pointed observations. X-ray detections of IFRS with different ratios of radio-to-infrared fluxes, will constrain the class-specific SED.

  1. Gravitational Coleman–Weinberg potential and its finite temperature counterpart

    Energy Technology Data Exchange (ETDEWEB)

    Bhattacharjee, Srijit [Astroparticle Physics and Cosmology Division, Saha Institute of Nuclear Physics, Kolkata 700064 (India); Discipline of Physics, Indian Institute of Technology Gandhinagar, Ahmedabad, Gujarat 382424 (India); Majumdar, Parthasarathi [Department of Physics, Ramakrishna Mission Vivekananada University, Belur Math, Howrah 711202 (India)

    2014-08-15

    Coleman–Weinberg (CW) phenomena for the case of gravitons minimally coupled to massless scalar field is studied. The one-loop effect completely vanishes if there is no self-interaction term present in the matter sector. The one-loop effective potential is shown to develop an instability in the form of acquiring an imaginary part, which can be traced to the tachyonic pole in the graviton propagator. The finite temperature counterpart of this CW potential is computed to study the behaviour of the potential in the high and low temperature regimes with respect to the typical energy scale of the theory. Finite temperature contribution to the imaginary part of gravitational CW potential exhibits a damped oscillatory behaviour; all thermal effects are damped out as the temperature vanishes, consistent with the zero-temperature result.

  2. ELECTROMAGNETIC COUNTERPARTS TO BLACK HOLE MERGERS DETECTED BY LIGO

    Energy Technology Data Exchange (ETDEWEB)

    Loeb, Abraham, E-mail: aloeb@cfa.harvard.edu [Department of Astronomy, Harvard University, 60 Garden St., Cambridge, MA 02138 (United States)

    2016-03-10

    Mergers of stellar-mass black holes (BHs), such as GW150914 observed by Laser Interferometer Gravitational Wave Observatory (LIGO), are not expected to have electromagnetic counterparts. However, the Fermi GBM detector identified a γ-ray transient 0.4 s after the gravitational wave (GW) signal GW150914 with consistent sky localization. I show that the two signals might be related if the BH binary detected by LIGO originated from two clumps in a dumbbell configuration that formed when the core of a rapidly rotating massive star collapsed. In that case, the BH binary merger was followed by a γ-ray burst (GRB) from a jet that originated in the accretion flow around the remnant BH. A future detection of a GRB afterglow could be used to determine the redshift and precise localization of the source. A population of standard GW sirens with GRB redshifts would provide a new approach for precise measurements of cosmological distances as a function of redshift.

  3. Unidentified EGRET sources and their possible Fermi counterparts

    International Nuclear Information System (INIS)

    Lyapin, A R; Arkhangelskaja, I V; Larin, D S

    2017-01-01

    Unidentified EGRET sources from 3EG catalog have been analyzed. Preliminary data analysis has shown at least 23 of these sources coincide with those in 3FGL Fermi catalogue within 1, 2 and 3 sigma error intervals of the coordinates and fluxes. Their properties are discussed in the presented work. Even 3-sigma difference allows supposing sources similarity because of more than 3-sigma distinctions in values of fluxes between identified EGRET sources and their Fermi counterparts. For instance, the coincidence between 3EG J1255-0549 and 3FGL J1256.1-0547 was reported in Fermi catalogues 1FGL, 2FGL, 3FGL. However, these sources fluxes (in units of 10 −8 photons × cm −2 × s −1 ) in the energy band E > 100 MeV were 179.7 ± 6.7 (3EG), 44.711 ± 0.724 (3FGL), 53.611 ± 0.997 (2FGL) and 67.939 ± 1.861 (1FGL). Such effect was observed for sufficient portion of identified EGRET sources. It could cause by troubles of particles identification by Fermi/LAT trigger system. Very often charged particles recognized as gamma-quanta because of wrong backsplash analysis. Nevertheless, gammas counts as charged particles due analogous reason and rejected during ground data processing. For example, it appears as geomagnetic modulation presence on gamma-quanta count rate latitudinal profiles in energy band E > 20 MeV. (paper)

  4. The Hunt for a Counterpart to GW150914

    Science.gov (United States)

    Kohler, Susanna

    2016-07-01

    On 14 September 2015, the Laser Interferometer Gravitational-wave Observatory (LIGO) in a pre-operative testing state at the time detected its first sign of gravitational-waves. The LIGO team sprang into action, performing data-quality checks on this unexpected signal. Within two days, they had sent a notification to 63 observing teams at observatories representing the entire electromagnetic spectrum, from radio to gamma-ray wavelengths.Illustration of a binary neutron star merger. The neutron stars 1) inspiral, 2) can produce a short gamma-ray burst, 3) can fling out hot, radioactive material in the form of a kilonova, and 4) form a massive neutron star or black hole with a possible remnant debris disk around it. [NASA/ESA/A. Feild (STScI)]Thus began the very first hunt for an electromagnetic counterpart to a detected gravitational wave signal.What were they looking for?As two compact objects in a binary system merge, the system is expected to emit energy in the form of gravitational waves. If both of the compact objects are black holes, were unlikely to see any electromagnetic radiation in the process, unless the merger is occurring in an (improbable) environment filled with gas and dust.But if one or both of the two compact objects is a neutron star, then there are a number of electromagnetic signatures that could occur due to energetic outflows. If a relativistic jet forms, we could see a short gamma-ray burst and X-ray, optical, and radio afterglows. Sub-relativistic outflows could produce optical and near-infrared signals, or a radio blast wave.Timeline of observations of GW150914, separated by wavelength band, and relative to the time of the gravitational-wave trigger. The top row shows LIGO information releases. The bottom four rows show high-energy, optical, near-infrared, and radio observations, respectively. Click for a closer look! [Abbott et al. 2016]Surprise SignalSince LIGO and Virgo (LIGOs European counterpart), wereprimarily expecting to detect

  5. A dynamic counterpart of Lamb vector in viscous compressible aerodynamics

    International Nuclear Information System (INIS)

    Liu, L Q; Wu, J Z; Shi, Y P; Zhu, J Y

    2014-01-01

    The Lamb vector is known to play a key role in incompressible fluid dynamics and vortex dynamics. In particular, in low-speed steady aerodynamics it is solely responsible for the total force acting on a moving body, known as the vortex force, with the classic two-dimensional (exact) Kutta–Joukowski theorem and three-dimensional (linearized) lifting-line theory as the most famous special applications. In this paper we identify an innovative dynamic counterpart of the Lamb vector in viscous compressible aerodynamics, which we call the compressible Lamb vector. Mathematically, we present a theorem on the dynamic far-field decay law of the vorticity and dilatation fields, and thereby prove that the generalized Lamb vector enjoys exactly the same integral properties as the Lamb vector does in incompressible flow, and hence the vortex-force theory can be generalized to compressible flow with exactly the same general formulation. Moreover, for steady flow of polytropic gas, we show that physically the force exerted on a moving body by the gas consists of a transverse force produced by the original Lamb vector and a new longitudinal force that reflects the effects of compression and irreversible thermodynamics. (paper)

  6. Analysis of SCTF/CCTF counterpart test results

    International Nuclear Information System (INIS)

    Okubo, Tsutomu; Sobajima, Makoto; Iwamura, Takamichi; Ohnuki, Akira; Abe, Yutaka; Adachi, Hiromichi; Murao, Yoshio

    1990-06-01

    Slab Core Test Facility (SCTF) and Cylindrical Core Test Facility (CCTF) are large scale experimental facilities of Japan Atomic Energy Research Institute (JAERI) for the investigation of reflooding behavior during a postulated loss-of-coolant accident (LOCA) in PWRs. Although the flow area scaling ratios of both facilities to a 1,000 MWe class PWR are the same and 1/21.4, the SCTF has the same core width as the radius of the reference PWR while the CCTF has a 1/4.5 times shorter core radius. Therefore, a few SCTF/CCTF counterpart tests were conducted in order to investigate the difference in core reflooding behavior between in the SCTF and CCTF tests as well as the effect of core radial length on core two-dimensional thermo-hydrodynamic behavior. This report present the test results and an analysis on them. Major results obtained are: (1) Taking account of the differences in test conditions and facility design, core reflooding behavior is considered to be similar between the SCTF and the CCTF test. Main difference of the facility design is in the effective core flow area and this is considered to result in the difference in core water accumulation behavior. (2) The effect of core radial length on core two-dimensional thermo-hydrodynamic behavior has been observed to be significant and heat transfer enhancement or degradation in radial direction is more significant for the longer radius core. (3) In addition, where the core power varies significantly in the radial direction, significant heat transfer enhancement has been observed in the higher power bundle during the LPCI period. Also, in the peripheral region, heat transfer degradation has been observed more significantly in the outer bundle even they have the same bundle power. (4) Magnitude of these heat transfer enhancement or degradation was larger at the higher elevation than the midplane level in the SCTF test, whereas smaller in the CCTF test. (author)

  7. Health and functional status and utilization of health care services among holocaust survivors and their counterparts in Israel.

    Science.gov (United States)

    Iecovich, Esther; Carmel, Sara

    2010-01-01

    To examine differences in health and functional status and in utilization of health services between holocaust survivors and their counterparts; and (b) to investigate if holocaust survivor status is a significant predictor of health status, functional status, and utilization of health services. The study included 1255 respondents of whom 272 were holocaust survivors. Interviews were conducted face-to-face at the respondents' homes. Participants were asked about their health (self-rated health and comorbidity) and functional (ADL and IADL) status, utilization of inpatient and outpatient health care services, age, gender, education, marital status, length of residence in Israel, and if they were holocaust survivors. Holocaust survivors, who were frailer and more chronically ill compared to their counterparts, visited their family physician and the nurse at the health care clinic more often than their counterparts did, and received more homecare services. Yet, there were no differences between them in the utilization of other health care services such as visits to specialists, emergency department, and hospitalizations. Holocaust survivors are more homebound due to more morbidity and functional limitations and therefore receive more health home care services that offset the utilization of other health services. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  8. Cyclic Fatigue Resistance of 3 Proprietary Rotary File Brands and their Analogous EdgeEndo Counterparts.

    Science.gov (United States)

    2018-04-26

    Resistance of 3 Proprietary Rotary File Brands and their Analogous EdgeEndo Counterparts. 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Sd...Endodontics 14. ABSTRACT Cyclic Fatigue Resistance of 3 Proprietary Rotary File Brands and their Analogous EdgeEndo Counterparts. David J. Weyh DDS...Resistance of 3 Proprietary Rotary File Brands and their Analogous EdgeEndo Counterparts. David J. Weyh DDS Jarom J. Ray DDS Introduction: The aim of this

  9. An integrable counterpart of the D-AKNS soliton hierarchy from so(3,R)

    International Nuclear Information System (INIS)

    Ma, Wen-Xiu

    2014-01-01

    An integrable counterpart of the D-AKNS soliton hierarchy is generated from a matrix spectral problem associated with so(3,R). Hamiltonian structures of the resulting counterpart soliton hierarchy are furnished by using the trace identity, which yields its Liouville integrability. -- Highlights: •Use the Lie algebra so(3,R) to generate a counterpart of the D-AKNS soliton hierarchy. •Generate Hamiltonian structures depending potentials by the trace identity. •Obtain hierarchies of independent commuting symmetries and conserved densities.

  10. X(3872) and the search for its bottomonium counterpart at the LHC

    CERN Document Server

    Toms, Konstantin; The ATLAS collaboration

    2016-01-01

    X(3872) history and theoretical status overview. ATLAS study of the ψ(2S) and X(3872) production. Search for X(3872) bottomonium counterpart by ATLAS. Search for Xb at CMS. Determination of X(3872) quantum numbers at LHCb.

  11. Chronic pancreatitis

    Science.gov (United States)

    Chronic pancreatitis - chronic; Pancreatitis - chronic - discharge; Pancreatic insufficiency - chronic; Acute pancreatitis - chronic ... abuse over many years. Repeated episodes of acute pancreatitis can lead to chronic pancreatitis. Genetics may be ...

  12. Comparison of nutrition composition of transgenic maize (chitinase gene) with its non-transgenic counterpart

    OpenAIRE

    Ping-mei, Yan; Yu-kui, Rui; Xiao-yan, Yan; Zheng, Chai; Qing, Wang; Jian-zhong, Du; Yi, Sun

    2011-01-01

    In order to compare the nutrition components of transgenic maize seeds (chitinase gene), achieved by the pollen-mediated approach, with its non-transgenic counterpart, Vitamin B1, vitamin B2, fatty acids and essential amino acids of transgenic maize seeds and their counterparts were analyzed by the Chinese national standard methods or AOAC methods. The results showed that the contents of all the six kinds of fatty acids detected in transgenic maize seeds were significantly higher than those i...

  13. Massive scalar counterpart of gravitational waves in scalarized neutron star binaries

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Jing [Sun Yat-sen University, School of Physics and Astronomy, Guangzhou (China)

    2017-09-15

    In analogy with spontaneous magnetization of ferromagnets below the Curie temperature, a neutron star (NS), with a compactness above a certain critical value, may undergo spontaneous scalarization and exhibit an interior nontrivial scalar configuration. Consequently, the exterior spacetime is changed, and an external scalar field appears, which subsequently triggers a scalarization of its companion. The dynamical interplay produces a gravitational scalar counterpart of tensor gravitational waves. In this paper, we resort to scalar-tensor theory and demonstrate that the gravitational scalar counterpart from a double neutron star (DNS) and a neutron star-white dwarf (NS-WD) system become massive. We report that (1) a gravitational scalar background field, arising from convergence of external scalar fields, plays the role of gravitational scalar counterpart in scalarized DNS binary, and the appearance of a mass-dimensional constant in a Higgs-like gravitational scalar potential is responsible for a massive gravitational scalar counterpart with a mass of the order of the Planck scale; (2) a dipolar gravitational scalar radiated field, resulting from differing binding energies of NS and WD, plays the role of a gravitational scalar counterpart in scalarized orbital shrinking NS-WDs, which oscillates around a local and scalar-energy-density-dependent minimum of the gravitational scalar potential and obtains a mass of the order of about 10{sup -21} eV/c{sup 2}. (orig.)

  14. Rice (Oryza sativa L.) containing the bar gene is compositionally equivalent to the nontransgenic counterpart.

    Science.gov (United States)

    Oberdoerfer, Regina B; Shillito, Raymond D; de Beuckeleer, Marc; Mitten, Donna H

    2005-03-09

    This publication presents an approach to assessing compositional equivalence between grain derived from glufosinate-tolerant rice grain, genetic event LLRICE62, and its nontransgenic counterpart. Rice was grown in the same manner as is common for commercial production, using either conventional weed control practices or glufosinate-ammonium herbicide. A two-season multisite trial design provided a robust data set to evaluate environmental effects between the sites. Statistical comparisons to test for equivalence were made between glufosinate-tolerant rice and a conventional counterpart variety. The key nutrients, carbohydrates, protein, iron, calcium, thiamin, riboflavin, and niacin, for which rice can be the principal dietary source, were investigated. The data demonstrate that rice containing the genetic locus LLRICE62 has the same nutritional value as its nontransgenic counterpart, and most results for nutritional components fall within the range of values reported for rice commodities in commerce.

  15. Observations of the First Electromagnetic Counterpart to a Gravitational-wave Source by the TOROS Collaboration

    Science.gov (United States)

    Díaz, M. C.; Macri, L. M.; Garcia Lambas, D.; Mendes de Oliveira, C.; Nilo Castellón, J. L.; Ribeiro, T.; Sánchez, B.; Schoenell, W.; Abramo, L. R.; Akras, S.; Alcaniz, J. S.; Artola, R.; Beroiz, M.; Bonoli, S.; Cabral, J.; Camuccio, R.; Castillo, M.; Chavushyan, V.; Coelho, P.; Colazo, C.; Costa-Duarte, M. V.; Cuevas Larenas, H.; DePoy, D. L.; Domínguez Romero, M.; Dultzin, D.; Fernández, D.; García, J.; Girardini, C.; Gonçalves, D. R.; Gonçalves, T. S.; Gurovich, S.; Jiménez-Teja, Y.; Kanaan, A.; Lares, M.; Lopes de Oliveira, R.; López-Cruz, O.; Marshall, J. L.; Melia, R.; Molino, A.; Padilla, N.; Peñuela, T.; Placco, V. M.; Quiñones, C.; Ramírez Rivera, A.; Renzi, V.; Riguccini, L.; Ríos-López, E.; Rodriguez, H.; Sampedro, L.; Schneiter, M.; Sodré, L.; Starck, M.; Torres-Flores, S.; Tornatore, M.; Zadrożny, A.

    2017-10-01

    We present the results of prompt optical follow-up of the electromagnetic counterpart of the gravitational-wave event GW170817 by the Transient Optical Robotic Observatory of the South Collaboration. We detected highly significant dimming in the light curves of the counterpart ({{Δ }}g=0.17+/- 0.03 mag, {{Δ }}r=0.14+/- 0.02 mag, {{Δ }}I=0.10+/- 0.03 mag) over the course of only 80 minutes of observations obtained ˜35 hr after the trigger with the T80-South telescope. A second epoch of observations, obtained ˜59 hr after the event with the EABA 1.5 m telescope, confirms the fast fading nature of the transient. The observed colors of the counterpart suggest that this event was a “blue kilonova” relatively free of lanthanides.

  16. Discovery of the optical counterpart and early optical observations of GRB 990712

    DEFF Research Database (Denmark)

    Sahu, K.C.; Vreesvijk, P.; Bakos, G.

    2000-01-01

    We present the discovery observations of the optical counterpart of the gamma-ray burst GRB 990712 taken 4.16 hr after the outburst and discuss its light curve observed in the V, R, and I bands during the first similar to 35 days after the outburst. The observed light curves were fitted with a po......We present the discovery observations of the optical counterpart of the gamma-ray burst GRB 990712 taken 4.16 hr after the outburst and discuss its light curve observed in the V, R, and I bands during the first similar to 35 days after the outburst. The observed light curves were fitted...

  17. Stability patterns for a size-structured population model and its stage-structured counterpart

    DEFF Research Database (Denmark)

    Zhang, Lai; Pedersen, Michael; Lin, Zhigui

    2015-01-01

    In this paper we compare a general size-structured population model, where a size-structured consumer feeds upon an unstructured resource, to its simplified stage-structured counterpart in terms of equilibrium stability. Stability of the size-structured model is understood in terms of an equivale...... to the population level....

  18. Counterpart experimental study of ISP-42 PANDA tests on PUMA facility

    International Nuclear Information System (INIS)

    Yang, Jun; Choi, Sung-Won; Lim, Jaehyok; Lee, Doo-Yong; Rassame, Somboon; Hibiki, Takashi; Ishii, Mamoru

    2013-01-01

    Highlights: ► Counterpart tests were performed on two large-scale BWR integral facilities. ► Similarity of post-LOCA system behaviors observed between two tests. ► Passive core and containment cooling systems work as design in both tests. -- Abstract: A counterpart test to the Passive Nachwärmeabfuhr und Druckabbau Test Anlage (Passive Decay Heat Removal and Depressurization Test Facility, PANDA) International Standard Problem (ISP)-42 test was conducted at the Purdue University Multi-Dimensional Integral Test Assembly (PUMA) facility. Aimed to support code validation on a range of light water reactor (LWR) containment issues, the ISP-42 test consists of six sequential phases (Phases A–F) with separately defined initial and boundary conditions, addressing different stages of anticipated accident scenario and system responses. The counterpart test was performed from Phases A to D, which are within the scope of the normal integral tests performed on the PUMA facility. A scaling methodology was developed by using the PANDA facility as prototype and PUMA facility as test model, and an engineering scaling has been applied to the PUMA facility. The counterpart test results indicated that functions of passive safety systems, such as passive containment cooling system (PCCS) start-up, gravity-driven cooling system (GDCS) discharge, PCCS normal operation and overload function were confirmed in both the PANDA and PUMA facilities with qualitative similarities

  19. Infrared Counterparts to Chandra X-Ray Sources in the Antennae

    Science.gov (United States)

    Clark, D. M.; Eikenberry, S. S.; Brandl, B. R.; Wilson, J. C.; Carson, J. C.; Henderson, C. P.; Hayward, T. L.; Barry, D. J.; Ptak, A. F.; Colbert, E. J. M.

    2007-03-01

    We use deep J (1.25 μm) and Ks (2.15 μm) images of the Antennae (NGC 4038/4039) obtained with the Wide-field InfraRed Camera on the Palomar 200 inch (5 m) telescope, together with the Chandra X-ray source list of Zezas and coworkers to search for infrared counterparts to X-ray point sources. We establish an X-ray/IR astrometric frame tie with ~0.5" rms residuals over a ~4.3' field. We find 13 ``strong'' IR counterparts brighter than Ks=17.8 mag and 99.9% confidence level that IR counterparts to X-ray sources are ΔMKs~1.2 mag more luminous than average non-X-ray clusters. We also note that the X-ray/IR matches are concentrated in the spiral arms and ``overlap'' regions of the Antennae. This implies that these X-ray sources lie in the most ``super'' of the Antennae's super star clusters, and thus trace the recent massive star formation history here. Based on the NH inferred from the X-ray sources without IR counterparts, we determine that the absence of most of the ``missing'' IR counterparts is not due to extinction, but that these sources are intrinsically less luminous in the IR, implying that they trace a different (possibly older) stellar population. We find no clear correlation between X-ray luminosity classes and IR properties of the sources, although small-number statistics hamper this analysis.

  20. IDENTIFYING ELUSIVE ELECTROMAGNETIC COUNTERPARTS TO GRAVITATIONAL WAVE MERGERS: AN END-TO-END SIMULATION

    International Nuclear Information System (INIS)

    Nissanke, Samaya; Georgieva, Alexandra; Kasliwal, Mansi

    2013-01-01

    Combined gravitational wave (GW) and electromagnetic (EM) observations of compact binary mergers should enable detailed studies of astrophysical processes in the strong-field gravity regime. This decade, ground-based GW interferometers promise to routinely detect compact binary mergers. Unfortunately, networks of GW interferometers have poor angular resolution on the sky and their EM signatures are predicted to be faint. Therefore, a challenging goal will be to unambiguously pinpoint the EM counterparts of GW mergers. We perform the first comprehensive end-to-end simulation that focuses on: (1) GW sky localization, distance measures, and volume errors with two compact binary populations and four different GW networks; (2) subsequent EM detectability by a slew of multiwavelength telescopes; and (3) final identification of the merger counterpart amidst a sea of possible astrophysical false positives. First, we find that double neutron star binary mergers can be detected out to a maximum distance of 400 Mpc (or 750 Mpc) by three (or five) detector GW networks, respectively. Neutron-star-black-hole binary mergers can be detected a factor of 1.5 further out; their median to maximum sky localizations are 50-170 deg 2 (or 6-65 deg 2 ) for a three (or five) detector GW network. Second, by optimizing depth, cadence, and sky area, we quantify relative fractions of optical counterparts that are detectable by a suite of different aperture-size telescopes across the globe. Third, we present five case studies to illustrate the diversity of scenarios in secure identification of the EM counterpart. We discuss the case of a typical binary, neither beamed nor nearby, and the challenges associated with identifying an EM counterpart at both low and high Galactic latitudes. For the first time, we demonstrate how construction of low-latency GW volumes in conjunction with local universe galaxy catalogs can help solve the problem of false positives. We conclude with strategies that would

  1. Do Foreign-Owned Firms Provide Better Working Conditions Than Their Domestic Counterparts? A Comparative Analysis

    OpenAIRE

    Hijzen, Alexander; Martins, Pedro S.; Schank, Thorsten; Upward, Richard

    2010-01-01

    This paper analyses to what extent working conditions in foreign-owned firms differ from those in their domestic counterparts. It makes three main contributions. First, we replicate the consensus in the empirical literature by applying a standardised methodology to firm-level data for three developed (Germany, Portugal, UK) and two emerging economies (Brazil, Indonesia). We show that, consistent with previous evidence, foreign-owned firms offer substantially higher average wages than domestic...

  2. HST/ACS Imaging of Omega Centauri: Optical Counterparts of Chandra X-Ray Sources

    Science.gov (United States)

    Cool, Adrienne M.; Haggard, Daryl; Arias, Tersi; Brochmann, Michelle; Dorfman, Jason; Gafford, April; White, Vivian; Anderson, Jay

    2013-02-01

    We present results of a search for optical counterparts of X-ray sources in and toward the globular cluster Omega Centauri (NGC 5139) using the Advanced Camera for Surveys (ACS) on the Hubble Space Telescope. The ACS data consist of a mosaic of Wide Field Channel images obtained using F625W, F435W, and F658N filters; with nine pointings we cover the central ~10' × 10' of the cluster and encompass 109 known Chandra sources. We find promising optical counterparts for 59 of the sources, ~40 of which are likely to be associated with the cluster. These include 27 candidate cataclysmic variables (CVs), 24 of which are reported here for the first time. Fourteen of the CV candidates are very faint, with absolute magnitudes in the range M 625 =10.4-12.6, making them comparable in brightness to field CVs near the period minimum discovered in the Sloan Digital Sky Survey. Additional optical counterparts include three BY Dra candidates, a possible blue straggler, and a previously reported quiescent low-mass X-ray binary. We also identify 3 foreground stars and 11 probable active galactic nuclei. Finally, we report the discovery of a group of seven stars whose X-ray properties are suggestive of magnetically active binaries, and whose optical counterparts lie on or very near the metal-rich anomalous giant and subgiant branches in ω Cen. If the apparent association between these seven stars and the RGB/SGB-a stars is real, then the frequency of X-ray sources in this metal-rich population is enhanced by a factor of at least five relative to the other giant and subgiant populations in the cluster. If these stars are not members of the metal-rich population, then they bring the total number of red stragglers (also known as sub-subgiants) that have been identified in ω to Cen 20, the largest number yet known in any globular cluster.

  3. The credit counterparts of broad money : a structural base for macroeconomic policy

    OpenAIRE

    Steele, Gerald

    2014-01-01

    Tautological structures bring clarity to arguments in macroeconomics: familiar structures relate to the circulation of money, the circular flow of real income, and the balance of international payments. Less familiar is a structure incorporating all aspects of macroeconomic policy interventions. The origins and use of the credit counterparts of broad money are examined in the context of the application of UK monetary policy in the period since 1945.

  4. Finding X-ray counterparts for unidentified sources in the 105 months BAT survey - 1

    Science.gov (United States)

    Stephen, J. B.; Bassani, L.; Malizia, A.; Masetti, N.; Ubertini, P.

    2018-02-01

    We provide X-ray counterparts for the unidentified Swift/BAT sources listed in the 105 month catalogue (Oh et al. 2018, ApJS in press). These associations were found by cross-correlating the list of U1,U2 and U3 sources with the ROSAT Bright (RASSBSC, Voges et al. 1999, A & A, 349, 389) and the XMM-Newton Slew (XMMSlew, Saxton et al. 2008, A & A, 480, 611) catalogues.

  5. Finding X-ray counterparts for unidentified sources in the 105 months BAT survey - 2

    Science.gov (United States)

    Stephen, J. B.; Bassani, L.; Malizia, A.; Masetti, N.; Ubertini, P.

    2018-02-01

    We provide X-ray counterparts for unidentified Swift/BAT sources in the 105 month catalogue (Oh et al. 2018, ApJS in press). They were found by cross-correlating the list of U1,U2 and U3 sources with the ROSAT Bright (RASSBSC, Voges et al. 1999, A & A, 349, 389) and XMM-Newton Slew (XMMSlew, Saxton et al. 2008, A & A, 480, 611) catalogues and optically identified as reported in Atel #11340.

  6. The optical counterpart of IGR J00291+5934 in quiescence

    Science.gov (United States)

    D'Avanzo, P.; Campana, S.; Covino, S.; Israel, G. L.; Stella, L.; Andreuzzi, G.

    2007-09-01

    Aims:The recent (December 2004) discovery of the sixth accretion-powered millisecond X-ray pulsar IGR J00291+5934 provides a very good chance to deepen our knowledge of such systems. Although these systems are well studied at high energies, poor informations are available for their optical/NIR counterparts during quiescence. Up to now, only for SAX J1808.4-3658, the first discovered system of this type, we have a secure multiband detection of its optical counterpart in quiescence. Among the seven known system IGR J00291+5934 is the one that resembles SAX J1808.4-3658 more closely. Methods: With the Italian 3.6 m TNG telescope, we have performed deep optical and NIR photometry of the field of IGR J00291+5934 during quiescence in order to look for the presence of a variable counterpart. Results: We present here the first multiband (VRIJH) detection of the optical and NIR counterpart of IGR J00291+5934 in quiescence as well as a deep upper limit in the K-band. We obtain an optical light curve that shows variability consistent with a sinusoidal modulation at the known 2.46 h orbital period and present evidence for a strongly irradiated companion. Based on observations made with the Italian Telescopio Nazionale Galileo (TNG) operated on the island of La Palma by the Fundación Galileo Galilei of the INAF (Istituto Nazionale di Astrofisica) at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias.

  7. INVESTIGATING THE OPTICAL COUNTERPART CANDIDATES OF FOUR INTEGRAL SOURCES LOCALIZED WITH CHANDRA

    International Nuclear Information System (INIS)

    Özbey Arabacı, Mehtap; Kalemci, Emrah; Tomsick, John A.; Bodaghee, Arash; Halpern, Jules; Chaty, Sylvain; Rodriguez, Jerome; Rahoui, Farid

    2012-01-01

    We report on the optical spectroscopic follow-up observations of the candidate counterparts to four INTEGRAL sources: IGR J04069+5042, IGR J06552–1146, IGR J21188+4901, and IGR J22014+6034. The candidate counterparts were determined with Chandra, and the optical observations were performed with 1.5 m RTT-150 telescope (TÜBİTAK National Observatory, Antalya, Turkey) and 2.4 m Hiltner Telescope (MDM Observatory, Kitt Peak, Arizona). Our spectroscopic results show that one of the two candidates of IGR J04069+5042 and the one observed for IGR J06552–1146 could be active late-type stars in RS CVn systems. However, according to the likelihood analysis based on Chandra and INTEGRAL, two optically weaker sources in the INTEGRAL error circle of IGR J06552–1146 have higher probabilities to be the actual counterpart. The candidate counterparts of IGR J21188+4901 are classified as an active M-type star and a late-type star. Among the optical spectra of four candidates of IGR J22014+6034, two show Hα emission lines, one is a late-type star, and the other is an M type. The likelihood analysis favors a candidate with no distinguishing features in the optical spectrum. Two of the candidates classified as M-type dwarfs, are similar to some IGR candidates claimed to be symbiotic stars. However, some of the prominent features of symbiotic systems are missing in our spectra, and their NIR colors are not consistent with those expected for giants. We consider the IR colors of all IGR candidates claimed to be symbiotic systems and find that low-resolution optical spectrum may not be enough for conclusive identification.

  8. The optical counterpart of the bright X-ray transient Swift J1745-26

    NARCIS (Netherlands)

    Muñoz-Darias, T.; de Ugarte Postigo, A.; Russell, D.M.; Guziy, S.; Gorosabel, J.; Casares, J.; Armas Padilla, M.; Charles, P.A.; Fender, R.P.; Belloni, T.M.; Lewis, F.; Motta, S.; Castro-Tirado, A.; Mundell, C.G.; Sánchez-Ramirez, R.; Thöne, C.C.

    2013-01-01

    We present a 30-day monitoring campaign of the optical counterpart of the bright X-ray transient Swift J1745−26, starting only 19 min after the discovery of the source. We observe the system peaking at i′ ∼ 17.6 on day six (MJD 561 92) to then decay at a rate of ∼0.04 mag d−1. We show that the

  9. Strategic Wholesale Pricing for an Incumbent Supplier Facing with a Competitive Counterpart

    OpenAIRE

    Sun, Jianwu

    2014-01-01

    We introduce a wholesale pricing strategy for an incumbent supplier facing with a competitive counterpart. We propose a profit function which considers both the present loss and future loss from a wholesale price and then study the optimal wholesale prices for different objectives about this profit function for the incumbent supplier. First, we achieve an optimal wholesale price for the incumbent supplier to maximize his expected profit. Then, to reduce the risk originating from the fluctuati...

  10. A comparative study between South African serial killers and their American counterparts

    OpenAIRE

    2009-01-01

    M.A. This dissertation explores the similarities and differences between South African serial killers and their American counterparts. Seven male candidates, each having committed their reign of terror within the relevant time period, have been included. The candidates compared well in home environments, number of friendships, emotional maturity, abuse undergone, temperament, and anti-social behaviour. Differences were found in comparing family bonding, wealth and education. This dissertat...

  11. Counterpart synchronization of duplex networks with delayed nodes and noise perturbation

    International Nuclear Information System (INIS)

    Wei, Xiang; Wu, Xiaoqun; Lu, Jun-an; Zhao, Junchan

    2015-01-01

    In the real world, many complex systems are represented not by single networks but rather by sets of interdependent ones. In these specific networks, nodes in one network mutually interact with nodes in other networks. This paper focuses on a simple representative case of two-layer networks (the so-called duplex networks) with unidirectional inter-layer couplings. That is, each node in one network depends on a counterpart in the other network. Accordingly, the former network is called the response layer and the latter network is the drive layer. Specifically, synchronization between each node in the drive layer and its counterpart in the response layer (counterpart synchronization (CS)) in these kinds of duplex networks with delayed nodes and noise perturbation is investigated. Based on the LaSalle-type invariance principle, a control technique is proposed and a sufficient condition is developed for realizing CS of duplex networks. Furthermore, two corollaries are derived as special cases. In addition, node dynamics within each layer can be varied and topologies of the two layers are not necessarily identical. Therefore, the proposed synchronization method can be applied to a wide range of multiplex networks. Numerical examples are provided to illustrate the feasibility and effectiveness of the results. (paper)

  12. DISCOVERY OF A TRANSIENT GAMMA-RAY COUNTERPART TO FRB 131104

    International Nuclear Information System (INIS)

    DeLaunay, J. J.; Murase, K.; Mészáros, P.; Keivani, A.; Messick, C.; Mostafá, M. A.; Oikonomou, F.; Tešić, G.; Turley, C. F.; Fox, D. B.

    2016-01-01

    We report our discovery in Swift satellite data of a transient gamma-ray counterpart (3.2 σ confidence) to the fast radio burst (FRB) FRB 131104, the first such counterpart to any FRB. The transient has a duration T _9_0 ≳ 100 s and a fluence S_γ ≈ 4 × 10"−"6 erg cm"−"2, increasing the energy budget for this event by more than a billion times; at the nominal z ≈ 0.55 redshift implied by its dispersion measure, the burst’s gamma-ray energy output is E_γ ≈ 5 × 10"5"1 erg. The observed radio to gamma-ray fluence ratio for FRB 131104 is consistent with a lower limit we derive from Swift observations of another FRB, which is not detected in gamma-rays, and with an upper limit previously derived for the brightest gamma-ray flare from SGR 1806−20, which was not detected in the radio. X-ray, ultraviolet, and optical observations beginning two days after the FRB do not reveal any associated afterglow, supernova, or transient; Swift observations exclude association with the brightest 65% of Swift gamma-ray burst (GRB) X-ray afterglows, while leaving the possibility of an associated supernova at much more than 10% the FRB’s nominal distance, D ≳ 320 Mpc, largely unconstrained. Transient high-luminosity gamma-ray emission arises most naturally in a relativistic outflow or shock breakout, such as, for example, from magnetar flares, GRBs, relativistic supernovae, and some types of galactic nuclear activity. Our discovery thus bolsters the case for an extragalactic origin for some FRBs and suggests that future rapid-response observations might identify long-lived counterparts, resolving the nature of these mysterious phenomena and realizing their promise as probes of cosmology and fundamental physics.

  13. INTERSTELLAR SCINTILLATION AND THE RADIO COUNTERPART OF THE FAST RADIO BURST FRB 150418

    Energy Technology Data Exchange (ETDEWEB)

    Akiyama, Kazunori [Massachusetts Institute of Technology, Haystack Observatory, Route 40, Westford, MA 01886 (United States); Johnson, Michael D., E-mail: kazu@haystack.mit.edu [Harvard Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States)

    2016-06-10

    Keane et al. have recently reported the discovery of a new fast radio burst (FRB), FRB 150418, with a promising radio counterpart at 5.5 and 7.5 GHz—a rapidly decaying source, falling from 200–300 μ Jy to 100 μ Jy on timescales of ∼6 days. This transient source may be associated with an elliptical galaxy at redshift z = 0.492, providing the first firm spectroscopic redshift for an FRB and the ability to estimate the density of baryons in the intergalactic medium via the combination of known redshift and radio dispersion of the FRB. An alternative explanation, first suggested by Williams and Berger, is that the identified counterpart may instead be a compact active galactic nucleus (AGN). The putative counterpart’s variation may then instead be extrinsic, caused by refractive scintillation in the ionized interstellar medium of the Milky Way, which would invalidate the association with FRB 150418. We examine this latter explanation in detail and show that the reported observations are consistent with scintillating radio emission from the core of a radio-loud AGN having a brightness temperature T {sub b} ≳ 10{sup 9} K. Using numerical simulations of the expected scattering for the line of sight to FRB 150418, we provide example images and light curves of such an AGN at 5.5 and 7.5 GHz. These results can be compared with continued radio monitoring to conclusively determine the importance of scintillation for the observed radio variability, and they show that scintillation is a critical consideration for continued searches for FRB counterparts at radio wavelengths.

  14. DISCOVERY OF A TRANSIENT GAMMA-RAY COUNTERPART TO FRB 131104

    Energy Technology Data Exchange (ETDEWEB)

    DeLaunay, J. J.; Murase, K.; Mészáros, P.; Keivani, A.; Messick, C.; Mostafá, M. A.; Oikonomou, F.; Tešić, G.; Turley, C. F. [Department of Physics, Pennsylvania State University, University Park, PA 16802 (United States); Fox, D. B., E-mail: jjd330@psu.edu [Department of Astronomy and Astrophysics, Pennsylvania State University, University Park, PA 16802 (United States)

    2016-11-20

    We report our discovery in Swift satellite data of a transient gamma-ray counterpart (3.2 σ confidence) to the fast radio burst (FRB) FRB 131104, the first such counterpart to any FRB. The transient has a duration T {sub 90} ≳ 100 s and a fluence S{sub γ} ≈ 4 × 10{sup −6} erg cm{sup −2}, increasing the energy budget for this event by more than a billion times; at the nominal z ≈ 0.55 redshift implied by its dispersion measure, the burst’s gamma-ray energy output is E{sub γ} ≈ 5 × 10{sup 51} erg. The observed radio to gamma-ray fluence ratio for FRB 131104 is consistent with a lower limit we derive from Swift observations of another FRB, which is not detected in gamma-rays, and with an upper limit previously derived for the brightest gamma-ray flare from SGR 1806−20, which was not detected in the radio. X-ray, ultraviolet, and optical observations beginning two days after the FRB do not reveal any associated afterglow, supernova, or transient; Swift observations exclude association with the brightest 65% of Swift gamma-ray burst (GRB) X-ray afterglows, while leaving the possibility of an associated supernova at much more than 10% the FRB’s nominal distance, D ≳ 320 Mpc, largely unconstrained. Transient high-luminosity gamma-ray emission arises most naturally in a relativistic outflow or shock breakout, such as, for example, from magnetar flares, GRBs, relativistic supernovae, and some types of galactic nuclear activity. Our discovery thus bolsters the case for an extragalactic origin for some FRBs and suggests that future rapid-response observations might identify long-lived counterparts, resolving the nature of these mysterious phenomena and realizing their promise as probes of cosmology and fundamental physics.

  15. INTERSTELLAR SCINTILLATION AND THE RADIO COUNTERPART OF THE FAST RADIO BURST FRB 150418

    International Nuclear Information System (INIS)

    Akiyama, Kazunori; Johnson, Michael D.

    2016-01-01

    Keane et al. have recently reported the discovery of a new fast radio burst (FRB), FRB 150418, with a promising radio counterpart at 5.5 and 7.5 GHz—a rapidly decaying source, falling from 200–300 μ Jy to 100 μ Jy on timescales of ∼6 days. This transient source may be associated with an elliptical galaxy at redshift z = 0.492, providing the first firm spectroscopic redshift for an FRB and the ability to estimate the density of baryons in the intergalactic medium via the combination of known redshift and radio dispersion of the FRB. An alternative explanation, first suggested by Williams and Berger, is that the identified counterpart may instead be a compact active galactic nucleus (AGN). The putative counterpart’s variation may then instead be extrinsic, caused by refractive scintillation in the ionized interstellar medium of the Milky Way, which would invalidate the association with FRB 150418. We examine this latter explanation in detail and show that the reported observations are consistent with scintillating radio emission from the core of a radio-loud AGN having a brightness temperature T _b ≳ 10"9 K. Using numerical simulations of the expected scattering for the line of sight to FRB 150418, we provide example images and light curves of such an AGN at 5.5 and 7.5 GHz. These results can be compared with continued radio monitoring to conclusively determine the importance of scintillation for the observed radio variability, and they show that scintillation is a critical consideration for continued searches for FRB counterparts at radio wavelengths.

  16. Bright optical synchrotron counterpart of the western hot spot in Pictor A

    International Nuclear Information System (INIS)

    Roeser, H.J.; Meisenheimer, K.; Royal Observatory, Edinburgh, Scotland)

    1987-01-01

    A B = 19.5 mag bright, highly polarized object was detected close to the western hot spot in Pictor A during an optical polarization survey of radio hot spots in classical double radio sources. The unresolved source exhibits a featureless continuum between 400 and 800 nm and is identified as the optical counterpart of the radio hot spot. It is surrounded by optical filaments aligned roughly perpendicular to the source axis. The hot spot is also marginally detected in an Einstein IPC frame. 17 references

  17. The radio and optical counterpart of the new Fermi LAT flaring source J0109+6134

    Science.gov (United States)

    Paredes, J. M.; Martí, J.; Peracaula, M.

    2010-02-01

    Following the recent ATELs #2414, #2416 and #2420 concerning the Fermi-LAT, AGILE and Swift/XRT consistent detections of the new gamma-ray flaring source J0109+6134, we wish to remind that the proposed radio counterpart (VCS2 J0109+6133/GT 0106+613) was extensively observed nearly two decades ago by different authors in the context of the GT catalogue of Galactic Plane radio sources (Taylor and Gregory 1983, AJ, 88, 1784; Gregory and Taylor 1986, AJ 92, 371).

  18. Understanding possible electromagnetic counterparts to loud gravitational wave events: Binary black hole effects on electromagnetic fields

    International Nuclear Information System (INIS)

    Palenzuela, Carlos; Lehner, Luis; Yoshida, Shin

    2010-01-01

    In addition to producing loud gravitational waves, the dynamics of a binary black hole system could induce emission of electromagnetic radiation by affecting the behavior of plasmas and electromagnetic fields in their vicinity. We study how the electromagnetic fields are affected by a pair of orbiting black holes through the merger. In particular, we show how the binary's dynamics induce a variability in possible electromagnetically induced emissions as well as an enhancement of electromagnetic fields during the late-merge and merger epochs. These time dependent features will likely leave their imprint in processes generating detectable emissions and can be exploited in the detection of electromagnetic counterparts of gravitational waves.

  19. HST/ACS IMAGING OF OMEGA CENTAURI: OPTICAL COUNTERPARTS OF CHANDRA X-RAY SOURCES

    International Nuclear Information System (INIS)

    Cool, Adrienne M.; Arias, Tersi; Brochmann, Michelle; Dorfman, Jason; Gafford, April; White, Vivian; Haggard, Daryl; Anderson, Jay

    2013-01-01

    We present results of a search for optical counterparts of X-ray sources in and toward the globular cluster Omega Centauri (NGC 5139) using the Advanced Camera for Surveys (ACS) on the Hubble Space Telescope. The ACS data consist of a mosaic of Wide Field Channel images obtained using F625W, F435W, and F658N filters; with nine pointings we cover the central ∼10' × 10' of the cluster and encompass 109 known Chandra sources. We find promising optical counterparts for 59 of the sources, ∼40 of which are likely to be associated with the cluster. These include 27 candidate cataclysmic variables (CVs), 24 of which are reported here for the first time. Fourteen of the CV candidates are very faint, with absolute magnitudes in the range M 625 =10.4-12.6, making them comparable in brightness to field CVs near the period minimum discovered in the Sloan Digital Sky Survey. Additional optical counterparts include three BY Dra candidates, a possible blue straggler, and a previously reported quiescent low-mass X-ray binary. We also identify 3 foreground stars and 11 probable active galactic nuclei. Finally, we report the discovery of a group of seven stars whose X-ray properties are suggestive of magnetically active binaries, and whose optical counterparts lie on or very near the metal-rich anomalous giant and subgiant branches in ω Cen. If the apparent association between these seven stars and the RGB/SGB-a stars is real, then the frequency of X-ray sources in this metal-rich population is enhanced by a factor of at least five relative to the other giant and subgiant populations in the cluster. If these stars are not members of the metal-rich population, then they bring the total number of red stragglers (also known as sub-subgiants) that have been identified in ω to Cen 20, the largest number yet known in any globular cluster.

  20. PSB-VVER counterpart experiment simulating a small cold leg break LOCA

    International Nuclear Information System (INIS)

    Blinkov, V.N.; Melikhov, O.I.; Kapustin, A.V.; Lipatov, I.A.; Dremin, G.I.; Nikonov, S.M.; Rovnov, A.A.; Elkin, I.V.; Pylev, S.S.

    2005-01-01

    Full text of publication follows: An experiment simulating a small break LOCA has been performed in PSB-VVER facility, under PSB-VVER OECD Project. The test is intended to be a counterpart one to an experiment performed in the LOBI integral test facility. The objectives of the PSB-VVER small cold leg break test are: to study VVER-1000 thermal hydraulic response following a small break in the cold leg, to provide data for code assessment regarding phenomena indicated in the VVER-1000 code validation matrix and to study the scaling effect. The scenario for the PSB-VVER experiment has been designed taking the LOBI BL-34 test as reference. The ratio of primary system volumes (without volume of the pressurizer and the surge line) has been chosen to scale the reference experiment conditions and to generate the conditions of PSB-VVER cold leg break experiment. The resulting conditions are compared with the LOBI cold leg break test conditions by means of different counterpart test criteria. Comparing the two experiments in terms of the criteria shows that basic requirements to the counterpart test are fulfilled. A pretest analysis with RELAP5/MOD3.2 code has shown that the PSBVVER small break experiment is expected to show the same relevant phenomena and main events as the LOBI BL-34 test. The predicted PSB-VVER primary pressure is very close to that measured in the LOBI facility. The measured pressure in the PSB-VVER primary system has turned out to be very close to that registered in LOBI BL-34 test. This verifies the approach used for developing the conditions of the PSB-VVER counterpart test. The experiment results and the RELAP5/MOD3.2 pretest calculation are in good agreement. A posttest calculation of the experiment with RELAP5/MOD3.2 code has been performed in order to assess the codes capability to simulate the phenomena relevant to the test. The code has shown a reasonable prediction of the phenomena measured in the experiment. (authors)

  1. PSB-VVER counterpart experiment simulating a small cold leg break LOCA

    Energy Technology Data Exchange (ETDEWEB)

    Blinkov, V.N.; Melikhov, O.I.; Kapustin, A.V.; Lipatov, I.A.; Dremin, G.I.; Nikonov, S.M.; Rovnov, A.A. [Elektrogorsk Research and Engineering Center, EREC, Bezymiannaja Street, 6, Elektrogorsk, Moscow Region, 142530 (Russian Federation); Elkin, I.V.; Pylev, S.S. [NSI RRC ' Kurchatov Institute' , Kurchatov Sq., 1, Moscow, 123182 (Russian Federation)

    2005-07-01

    Full text of publication follows: An experiment simulating a small break LOCA has been performed in PSB-VVER facility, under PSB-VVER OECD Project. The test is intended to be a counterpart one to an experiment performed in the LOBI integral test facility. The objectives of the PSB-VVER small cold leg break test are: to study VVER-1000 thermal hydraulic response following a small break in the cold leg, to provide data for code assessment regarding phenomena indicated in the VVER-1000 code validation matrix and to study the scaling effect. The scenario for the PSB-VVER experiment has been designed taking the LOBI BL-34 test as reference. The ratio of primary system volumes (without volume of the pressurizer and the surge line) has been chosen to scale the reference experiment conditions and to generate the conditions of PSB-VVER cold leg break experiment. The resulting conditions are compared with the LOBI cold leg break test conditions by means of different counterpart test criteria. Comparing the two experiments in terms of the criteria shows that basic requirements to the counterpart test are fulfilled. A pretest analysis with RELAP5/MOD3.2 code has shown that the PSBVVER small break experiment is expected to show the same relevant phenomena and main events as the LOBI BL-34 test. The predicted PSB-VVER primary pressure is very close to that measured in the LOBI facility. The measured pressure in the PSB-VVER primary system has turned out to be very close to that registered in LOBI BL-34 test. This verifies the approach used for developing the conditions of the PSB-VVER counterpart test. The experiment results and the RELAP5/MOD3.2 pretest calculation are in good agreement. A posttest calculation of the experiment with RELAP5/MOD3.2 code has been performed in order to assess the codes capability to simulate the phenomena relevant to the test. The code has shown a reasonable prediction of the phenomena measured in the experiment. (authors)

  2. Optical and radio counterpart of Circinus X-1 (3U 1516-56)

    Energy Technology Data Exchange (ETDEWEB)

    Whelan, J A.J.; Murdin, P G; Peterson, B A [Anglo-Australian Observatory, Epping (Australia); and others

    1977-11-01

    Circinus X-1 (3U 1516-56) has a radio counterpart which, at high frequencies, show flares with the same 16.6 day periodicity as the X-ray intensity. In each cycle the radio flare occurs shortly after the intensity drop-off which defines the X-ray modulation. The radio source is positionally coincident with a faint red star having very strong H..cap alpha.. and weak He I emission lines which are probably variable. The object may be an early-type emission-line star or a symbiotic star, at a distance of 10 kpc.

  3. THE IDENTIFICATION OF THE X-RAY COUNTERPART TO PSR J2021+4026

    Energy Technology Data Exchange (ETDEWEB)

    Weisskopf, Martin C.; Elsner, Ronald F.; O' Dell, Stephen L.; Tennant, Allyn F. [NASA Marshall Space Flight Center, Space Science Office, VP62, Huntsville, AL 35812 (United States); Romani, Roger W. [Department of Physics, Stanford University, Stanford, CA 94305 (United States); Razzano, Massimiliano [Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy); Belfiore, Andrea; Saz Parkinson, Pablo; Ziegler, Marcus; Dormody, Michael [Santa Cruz Institute for Particle Physics, Department of Physics, University of California at Santa Cruz, Santa Cruz, CA 95064 (United States); Ray, Paul S. [Space Science Division, Naval Research Laboratory, Washington, DC 20375 (United States); Kerr, Matthew [Kavli Institute for Particle Astrophysics and Cosmology, Stanford University, 452 Lomita Mall, Stanford, CA 94305 (United States); Harding, Alice [Astrophysics Science Division, NASA Goddard Space Flight Center, Code 663, Greenbelt, MD 20771 (United States); Swartz, Douglas A. [Universities Space Research Association, NASA Marshall Space Flight Center, Space Science Office, VP62, Huntsville, AL 35812 (United States); Carraminana, Alberto [Instituto Nacional de Astrofisica, Optica y Electronica, Luis Enrique Erro 1, Tonantzintla, Puebla 72840 (Mexico); Becker, Werner; Kanbach, Gottfried [Max-Planck-Institut fuer extraterrestrische Physik, 85741 Garching bei Muenchen (Germany); De Luca, Andrea [INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica, I-20133 Milano (Italy); Thompson, David J. [Astroparticle Physics Laboratory, NASA Goddard Space Flight Center, Code 661, Greenbelt, MD 20771 (United States)

    2011-12-10

    We report the probable identification of the X-ray counterpart to the {gamma}-ray pulsar PSR J2021+4026 using imaging with the Chandra X-ray Observatory Advanced CCD Imaging Spectrometer and timing analysis with the Fermi satellite. Given the statistical and systematic errors, the positions determined by both satellites are coincident. The X-ray source position is R.A. 20{sup h}21{sup m}30.{sup s}733, decl. +40 Degree-Sign 26'46.''04 (J2000) with an estimated uncertainty of 1.''3 combined statistical and systematic error. Moreover, both the X-ray to {gamma}-ray and the X-ray to optical flux ratios are sensible assuming a neutron star origin for the X-ray flux. The X-ray source has no cataloged infrared-to-visible counterpart and, through new observations, we set upper limits to its optical emission of i' > 23.0 mag and r' > 25.2 mag. The source exhibits an X-ray spectrum with most likely both a power law and a thermal component. We also report on the X-ray and visible light properties of the 43 other sources detected in our Chandra observation.

  4. GRB 170817A as a jet counterpart to gravitational wave trigger GW 170817

    Science.gov (United States)

    Lamb, Gavin P.; Kobayashi, Shiho

    2018-05-01

    Fermi/GBM (Gamma-ray Burst Monitor) and INTEGRAL (the International Gamma-ray Astrophysics Laboratory) reported the detection of the γ-ray counterpart, GRB 170817A, to the LIGO (Light Interferometer Gravitational-wave Observatory)/Virgo gravitational wave detected binary neutron star merger, GW 170817. GRB 170817A is likely to have an internal jet or another origin such as cocoon emission, shock-breakout, or a flare from a viscous disc. In this paper we assume that the γ-ray emission is caused by energy dissipation within a relativistic jet and we model the afterglow synchrotron emission from a reverse- and forward-shock in the outflow. We show the afterglow for a low-luminosity γ-ray burst (GRB) jet with a high Lorentz-factor (Γ); a low-Γ and low-kinetic energy jet; a low-Γ, high kinetic energy jet; structured jets viewed at an inclination within the jet-half-opening angle; and an off-axis `typical' GRB jet. All jet models will produce observable afterglows on various timescales. The late-time afterglow from 10-110 days can be fit by a Gaussian structured jet viewed at a moderate inclination, however the GRB is not directly reproduced by this model. These jet afterglow models can be used for future GW detected NS merger counterparts with a jet afterglow origin.

  5. Tribological Response of Heat Treated AISI 52100 Steels Against Steel and Ceramic Counterparts

    Directory of Open Access Journals (Sweden)

    Türedi E.

    2017-09-01

    Full Text Available AISI 52100 bearing steels are commonly used in applications requiring high hardness and abrasion resistance. The bearing steels are working under dynamic loads in service conditions and their toughness properties become important. In order to provide the desired mechanical properties, various heat treatments (austenizing, quenching and tempering are usually applied. In this study, AISI 52100 bearing steel samples were austenized at 900°C for ½ h and water quenched to room temperature. Then tempering was carried out at 795°C, 400°C and 200°C for ½ h. In order to investigate the effect of heat treatment conditions on wear behavior, dry friction tests were performed according to ASTM G99-05 Standard with a ‘ball-on-disk’ type tribometer. The samples were tested against steel and ceramic counterparts using the parameters of 100 m distance and 30 N load and 0.063 m/s rotational speed. After wear test, the surface characterization was carried out using microscopy. Wear loss values were calculated using a novel optical method on both flat and counterpart specimens.

  6. THE IDENTIFICATION OF THE X-RAY COUNTERPART TO PSR J2021+4026

    International Nuclear Information System (INIS)

    Weisskopf, Martin C.; Elsner, Ronald F.; O'Dell, Stephen L.; Tennant, Allyn F.; Romani, Roger W.; Razzano, Massimiliano; Belfiore, Andrea; Saz Parkinson, Pablo; Ziegler, Marcus; Dormody, Michael; Ray, Paul S.; Kerr, Matthew; Harding, Alice; Swartz, Douglas A.; Carramiñana, Alberto; Becker, Werner; Kanbach, Gottfried; De Luca, Andrea; Thompson, David J.

    2011-01-01

    We report the probable identification of the X-ray counterpart to the γ-ray pulsar PSR J2021+4026 using imaging with the Chandra X-ray Observatory Advanced CCD Imaging Spectrometer and timing analysis with the Fermi satellite. Given the statistical and systematic errors, the positions determined by both satellites are coincident. The X-ray source position is R.A. 20 h 21 m 30. s 733, decl. +40°26'46.''04 (J2000) with an estimated uncertainty of 1.''3 combined statistical and systematic error. Moreover, both the X-ray to γ-ray and the X-ray to optical flux ratios are sensible assuming a neutron star origin for the X-ray flux. The X-ray source has no cataloged infrared-to-visible counterpart and, through new observations, we set upper limits to its optical emission of i' > 23.0 mag and r' > 25.2 mag. The source exhibits an X-ray spectrum with most likely both a power law and a thermal component. We also report on the X-ray and visible light properties of the 43 other sources detected in our Chandra observation.

  7. Motor skills in Czech children with attention-deficit/hyperactivity disorder and their neurotypical counterparts.

    Science.gov (United States)

    Scharoun, S M; Bryden, P J; Otipkova, Z; Musalek, M; Lejcarova, A

    2013-11-01

    Attention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed neurobehavioural disorder. Characterized by recurring problems with impulsiveness and inattention in combination with hyperactivity, motor impairments have also been well documented in the literature. The aim of this study was to compare the fine and gross motor skills of male and female children with ADHD and their neurotypical counterparts within seven skill assessments. This included three fine motor tasks: (1) spiral tracing, (2) dot filling, (3) tweezers and beads; and four gross motor tasks: (1) twistbox, (2) foot tapping, (3) small plate finger tapping, and (4) large plate finger tapping. It was hypothesized that children with ADHD would display poorer motor skills in comparison to neurotypical controls in both fine and gross motor assessments. However, statistically significant differences between the groups only emerged in four of the seven tasks (spiral tracing, dot filling, tweezers and beads and foot tapping). In line with previous findings, the complexity underlying upper limb tasks solidified the divide in performance between children with ADHD and their neurotypical counterparts. In light of similar research, impairments in lower limb motor skill were also observed. Future research is required to further delineate trends in motor difficulties in ADHD, while further investigating the underlying mechanisms of impairment. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. Probing extra dimension through gravitational wave observations of compact binaries and their electromagnetic counterparts

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Hao; Gu, Bao-Min; Wang, Yong-Qiang; Liu, Yu-Xiao [Institute of Theoretical Physics, Lanzhou University, Lanzhou 730000 (China); Huang, Fa Peng [Theoretical Physics Division, Institute of High Energy Physics, Chinese Academy of Sciences, P.O. Box 918-4, Beijing 100049 (China); Meng, Xin-He, E-mail: yuh13@lzu.edu.cn, E-mail: gubm15@lzu.edu.cn, E-mail: huangfp@ihep.ac.cn, E-mail: yqwang@lzu.edu.cn, E-mail: xhm@nankai.edu.cn, E-mail: liuyx@lzu.edu.cn [School of Physics, Nankai University, Tianjin 300071 (China)

    2017-02-01

    The future gravitational wave (GW) observations of compact binaries and their possible electromagnetic counterparts may be used to probe the nature of the extra dimension. It is widely accepted that gravitons and photons are the only two completely confirmed objects that can travel along null geodesics in our four-dimensional space-time. However, if there exist extra dimensions and only GWs can propagate freely in the bulk, the causal propagations of GWs and electromagnetic waves (EMWs) are in general different. In this paper, we study null geodesics of GWs and EMWs in a five-dimensional anti-de Sitter space-time in the presence of the curvature of the universe. We show that for general cases the horizon radius of GW is longer than EMW within equal time. Taking the GW150914 event detected by the Advanced Laser Interferometer Gravitational-Wave Observatory and the X-ray event detected by the Fermi Gamma-ray Burst Monitor as an example, we study how the curvature k and the constant curvature radius l affect the horizon radii of GW and EMW in the de Sitter and Einstein-de Sitter models of the universe. This provides an alternative method for probing extra dimension through future GW observations of compact binaries and their electromagnetic counterparts.

  9. A CANDIDATE OPTICAL COUNTERPART TO THE MIDDLE AGED γ -RAY PULSAR PSR J1741–2054

    Energy Technology Data Exchange (ETDEWEB)

    Mignani, R. P.; Marelli, M.; Luca, A. De; Salvetti, D.; Belfiore, A. [INAF—Istituto di Astrofisica Spaziale e Fisica Cosmica Milano, via E. Bassini 15, I-20133, Milano (Italy); Testa, V. [INAF—Osservatorio Astronomico di Roma, via Frascati 33, I-00040, Monteporzio (Italy); Pierbattista, M. [Department of Astrophysics and Theory of Gravity, Maria Curie-Sklodowska University, ul. Radziszewskiego 10, 20-031 Lublin (Poland); Razzano, M. [Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, I-56127 Pisa (Italy); Shearer, A.; Moran, P. [Centre for Astronomy, National University of Ireland, Newcastle Road, Galway (Ireland)

    2016-07-10

    We carried out deep optical observations of the middle aged γ -ray pulsar PSR J1741−2054 with the Very Large Telescope (VLT). We identified two objects, of magnitudes m {sub v} = 23.10 ± 0.05 and m {sub v} = 25.32 ± 0.08, at positions consistent with the very accurate Chandra coordinates of the pulsar, the faintest of which is more likely to be its counterpart. From the VLT images we also detected the known bow-shock nebula around PSR J1741−2054. The nebula is displaced by ∼0.″9 (at the 3 σ confidence level) with respect to its position measured in archival data, showing that the shock propagates in the interstellar medium consistently with the pulsar proper motion. Finally, we could not find evidence of large-scale extended optical emission associated with the pulsar wind nebula detected by Chandra , down to a surface brightness limit of ∼28.1 mag arcsec{sup −2}. Future observations are needed to confirm the optical identification of PSR J1741−2054 and characterize the spectrum of its counterpart.

  10. THE VARIABLE NEAR-INFRARED COUNTERPART OF THE MICROQUASAR GRS 1758–258

    International Nuclear Information System (INIS)

    Luque-Escamilla, Pedro L.; Martí, Josep; Muñoz-Arjonilla, Álvaro J.

    2014-01-01

    We present a new study of the microquasar system GRS 1758–258 in the near-infrared domain based on archival observations with the Hubble Space Telescope and the NICMOS camera. In addition to confirming the near-infrared counterpart pointed out by Muñoz-Arjonilla et al., we show that this object displays significant photometric variability. From its average magnitudes, we also find that GRS 1758–258 fits well within the correlation between the optical/near-infrared and X-ray luminosity known to exist for low-mass, black-hole candidate X-ray binaries in a hard state. Moreover, the spectral energy distribution built using all radio, near-infrared, and X-ray data available closest in time to the NICMOS observations can be reasonably interpreted in terms of a self-absorbed radio jet and an irradiated accretion disk model around a stellar-mass black hole. All these facts match the expected behavior of a compact binary system and strengthen our confidence in the counterpart identification

  11. Core-collapse supernovae as possible counterparts of IceCube neutrino multiplets

    Energy Technology Data Exchange (ETDEWEB)

    Strotjohann, Nora Linn; Kowalski, Marek; Franckowiak, Anna [DESY, Zeuthen (Germany); Voge, Markus [Bonn Univ. (Germany). Physikalisches Institut; Collaboration: IceCube-Collaboration

    2016-07-01

    While an astrophysical neutrino flux has been detected by the IceCube Neutrino Observatory its sources remain so far unidentified. IceCube's Optical Follow-up Program is designed to search for the counterparts of neutrino multiplets using the full energy range of the IceCube detector down to 100 GeV. Two or more muon neutrinos arriving from the same direction within few seconds can trigger follow-up observations with optical and X-ray telescopes. Since 2010 the Palomar Transient Factory has followed up about 40 such neutrino alerts and detected several supernovae. Many of the detections are however likely random coincidences. In this talk I describe our search for supernovae and the prospects of identifying a supernova as a source of high-energy neutrinos.

  12. Strategic wholesale pricing for an incumbent supplier facing with a competitive counterpart.

    Science.gov (United States)

    Sun, Jianwu

    2014-01-01

    We introduce a wholesale pricing strategy for an incumbent supplier facing with a competitive counterpart. We propose a profit function which considers both the present loss and future loss from a wholesale price and then study the optimal wholesale prices for different objectives about this profit function for the incumbent supplier. First, we achieve an optimal wholesale price for the incumbent supplier to maximize his expected profit. Then, to reduce the risk originating from the fluctuation in the competitive supplier's wholesale price, we integrate the conditional value-at-risk (CVaR) measure in financial risk management into this study and derive an optimal wholesale price to maximize CVaR about profit for the incumbent supplier. Besides, the properties of the two optimal wholesale prices are discussed. Finally, some management insights are suggested for the incumbent supplier in a competitive setting.

  13. Experiment data report for semiscale Mod-1 test S-06-4 (LOFT counterpart test)

    International Nuclear Information System (INIS)

    Gillins, R.L.; Sackett, K.E.; Coppin, C.E.

    1977-12-01

    Recorded test data are presented for Test S-06-4 of the Semiscale Mod-1 LOFT counterpart test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-06-4 was conducted from initial conditions of 15,653 kPa and 564 K to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold leg of the intact loop to simulate emergency core coolant injection in a PWR. The heater rods in the electrically heated core were operated at an axial peak power density which was 100 percent of the maximum peak power density

  14. Experiment data report for semiscale Mod-1 test S-06-1 (LOFT counterpart test)

    International Nuclear Information System (INIS)

    Collins, B.L.; Patton, M.L. Jr.; Sackett, K.E.

    1977-07-01

    Recorded test data are presented for Test S-06-1 of the Semiscale Mod-1 LOFT counterpart test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying an hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-06-1 was conducted from initial conditions of 15 568 kPa and 564 K to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold leg of the intact loop to simulate emergency core coolant injection in a PWR. The heater rods in the electrically heated core were operated at an axial peak power density which was 30% of the maximum peak power density

  15. Experiment data report for semiscale Mod-1 Test S-06-2 (LOFT counterpart test)

    International Nuclear Information System (INIS)

    Patton, M.L. Jr.; Collins, B.L.; Sackett, K.E.

    1977-08-01

    Recorded test data are presented for Test S-06-2 of the Semiscale Mod-1 LOFT counterpart test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying an hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-06-2 was conducted from initial conditions of 15 513 kPa and 563 K to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold leg of the intact loop to simulate emergency core coolant injection in a PWR. The heater rods in the electrically heated core were operated at an axial peak power density which was 50% of the maximum peak power density

  16. A systematic search for dwarf counterparts to ultra compact high velocity clouds

    Science.gov (United States)

    Bennet, Paul; Sand, David J.; Crnojevic, Denija; Strader, Jay

    2015-01-01

    Observations of the Universe on scales smaller than typical, massive galaxies challenge the standard Lambda Cold Dark Matter paradigm for structure formation. It is thus imperative to discover and characterize the faintest dwarf galaxy systems, not just within the Local Group, but in relatively isolated environments as well in order to properly connect them with models of structure formation. Here we report on a systematic search of public ultraviolet and optical archives for dwarf galaxy counterparts to so-called Ultra Compact High Velocity Clouds (UCHVCs), which are compact, isolated HI sources recently found in the Galactic Arecibo L-band Feed Array-HI (GALFA-HI) and Arecibo Legacy Fast ALFA (ALFALFA-HI) surveys. Our search has uncovered at least three strong dwarf galaxy candidates, and we present their inferred star formation rate and structural properties here.

  17. Strategic Wholesale Pricing for an Incumbent Supplier Facing with a Competitive Counterpart

    Directory of Open Access Journals (Sweden)

    Jianwu Sun

    2014-01-01

    Full Text Available We introduce a wholesale pricing strategy for an incumbent supplier facing with a competitive counterpart. We propose a profit function which considers both the present loss and future loss from a wholesale price and then study the optimal wholesale prices for different objectives about this profit function for the incumbent supplier. First, we achieve an optimal wholesale price for the incumbent supplier to maximize his expected profit. Then, to reduce the risk originating from the fluctuation in the competitive supplier’s wholesale price, we integrate the conditional value-at-risk (CVaR measure in financial risk management into this study and derive an optimal wholesale price to maximize CVaR about profit for the incumbent supplier. Besides, the properties of the two optimal wholesale prices are discussed. Finally, some management insights are suggested for the incumbent supplier in a competitive setting.

  18. A SEARCH FOR AN OPTICAL COUNTERPART TO THE GRAVITATIONAL-WAVE EVENT GW151226

    Energy Technology Data Exchange (ETDEWEB)

    Smartt, S. J.; Smith, K. W.; Young, D. R.; Inserra, C.; Wright, D. E.; Jerkstrand, A.; Maguire, K.; Mueller, B. [Astrophysics Research Centre, School of Mathematics and Physics, Queens University Belfast, Belfast BT7 1NN (United Kingdom); Chambers, K. C.; Huber, M. E.; Denneau, L.; Flewelling, H.; Heinze, A.; Magnier, E. A.; Sherstyuk, A.; Stalder, B.; Schultz, A. S. B. [Institute of Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); Chen, T.-W. [Max-Planck-Institut für Extraterrestrische Physik, Giessenbachstraße 1, D-85748, Garching (Germany); Coughlin, M. [Department of Physics, Harvard University, Cambridge, MA 02138 (United States); Rest, A., E-mail: s.smartt@qub.ac.uk [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); and others

    2016-08-20

    We present a search for an electromagnetic counterpart of the gravitational-wave source GW151226. Using the Pan-STARRS1 telescope we mapped out 290 square degrees in the optical i {sub P1} filter, starting 11.5 hr after the LIGO information release and lasting for an additional 28 days. The first observations started 49.5 hr after the time of the GW151226 detection. We typically reached sensitivity limits of i {sub P1} = 20.3–20.8 and covered 26.5% of the LIGO probability skymap. We supplemented this with ATLAS survey data, reaching 31% of the probability region to shallower depths of m ≃ 19. We found 49 extragalactic transients (that are not obviously active galactic nuclei), including a faint transient in a galaxy at 7 Mpc (a luminous blue variable outburst) plus a rapidly decaying M-dwarf flare. Spectral classification of 20 other transient events showed them all to be supernovae. We found an unusual transient, PS15dpn, with an explosion date temporally coincident with GW151226, that evolved into a type Ibn supernova. The redshift of the transient is secure at z = 0.1747 ± 0.0001 and we find it unlikely to be linked, since the luminosity distance has a negligible probability of being consistent with that of GW151226. In the 290 square degrees surveyed we therefore do not find a likely counterpart. However we show that our survey strategy would be sensitive to NS–NS mergers producing kilonovae at D{sub L} ≲ 100 Mpc, which is promising for future LIGO/Virgo searches.

  19. Subaru Hyper Suprime-Cam Survey for an optical counterpart of GW170817

    Science.gov (United States)

    Tominaga, Nozomu; Tanaka, Masaomi; Morokuma, Tomoki; Utsumi, Yousuke; Yamaguchi, Masaki S.; Yasuda, Naoki; Tanaka, Masayuki; Yoshida, Michitoshi; Fujiyoshi, Takuya; Furusawa, Hisanori; Kawabata, Koji S.; Lee, Chien-Hsiu; Motohara, Kentaro; Ohsawa, Ryou; Ohta, Kouji; Terai, Tsuyoshi; Abe, Fumio; Aoki, Wako; Asakura, Yuichiro; Barway, Sudhanshu; Bond, Ian A.; Fujisawa, Kenta; Honda, Satoshi; Ioka, Kunihito; Itoh, Youichi; Kawai, Nobuyuki; Kim, Ji Hoon; Koshimoto, Naoki; Matsubayashi, Kazuya; Miyazaki, Shota; Saito, Tomoki; Sekiguchi, Yuichiro; Sumi, Takahiro; Tristram, Paul J.

    2018-03-01

    We perform a z-band survey for an optical counterpart of the binary neutron star coalescence GW170817 with Subaru/Hyper Suprime-Cam. Our untargeted transient search covers 23.6 deg2 corresponding to the 56.6% credible region of GW170817 and reaches the 50% completeness magnitude of 20.6 mag on average. As a result, we find 60 candidate extragalactic transients, including J-GEM17btc (also known as SSS17a/DLT17ck). While J-GEM17btc is associated with NGC 4993, which is firmly located inside the 3D skymap of GW170817, the other 59 candidates do not have distance information in the GLADE v2 catalog or NASA/IPAC Extragalactic Database. Among 59 of the candidates, 58 are located at the center of extended objects in the Pan-STARRS1 catalog, while one candidate has an offset. We present location, z-band apparent magnitude, and time variability of the candidates and evaluate the probabilities that they are located within the 3D skymap of GW170817. The probability for J-GEM17btc is 64%, which is much higher than for the other 59 candidates (9.3 × 10-3-2.1 × 10-1%). Furthermore, the possibility that at least one of the other 59 candidates is located within the 3D skymap is only 3.2%. Therefore, we conclude that J-GEM17btc is the most likely and distinguished candidate to be the optical counterpart of GW170817.

  20. Subaru Hyper Suprime-Cam Survey for an optical counterpart of GW170817‡

    Science.gov (United States)

    Tominaga, Nozomu; Tanaka, Masaomi; Morokuma, Tomoki; Utsumi, Yousuke; Yamaguchi, Masaki S.; Yasuda, Naoki; Tanaka, Masayuki; Yoshida, Michitoshi; Fujiyoshi, Takuya; Furusawa, Hisanori; Kawabata, Koji S.; Lee, Chien-Hsiu; Motohara, Kentaro; Ohsawa, Ryou; Ohta, Kouji; Terai, Tsuyoshi; Abe, Fumio; Aoki, Wako; Asakura, Yuichiro; Barway, Sudhanshu; Bond, Ian A.; Fujisawa, Kenta; Honda, Satoshi; Ioka, Kunihito; Itoh, Youichi; Kawai, Nobuyuki; Kim, Ji Hoon; Koshimoto, Naoki; Matsubayashi, Kazuya; Miyazaki, Shota; Saito, Tomoki; Sekiguchi, Yuichiro; Sumi, Takahiro; Tristram, Paul J.

    2018-02-01

    We perform a z-band survey for an optical counterpart of the binary neutron star coalescence GW170817 with Subaru/Hyper Suprime-Cam. Our untargeted transient search covers 23.6 deg2 corresponding to the 56.6% credible region of GW170817 and reaches the 50% completeness magnitude of 20.6 mag on average. As a result, we find 60 candidate extragalactic transients, including J-GEM17btc (also known as SSS17a/DLT17ck). While J-GEM17btc is associated with NGC 4993, which is firmly located inside the 3D skymap of GW170817, the other 59 candidates do not have distance information in the GLADE v2 catalog or NASA/IPAC Extragalactic Database. Among 59 of the candidates, 58 are located at the center of extended objects in the Pan-STARRS1 catalog, while one candidate has an offset. We present location, z-band apparent magnitude, and time variability of the candidates and evaluate the probabilities that they are located within the 3D skymap of GW170817. The probability for J-GEM17btc is 64%, which is much higher than for the other 59 candidates (9.3 × 10-3-2.1 × 10-1%). Furthermore, the possibility that at least one of the other 59 candidates is located within the 3D skymap is only 3.2%. Therefore, we conclude that J-GEM17btc is the most likely and distinguished candidate to be the optical counterpart of GW170817.

  1. A Search for Optical Counterparts of Chandra Sources in Omega Centauri using ACS

    Science.gov (United States)

    Haggard, D.; Fuller, A. D.; Dorfman, J. L.; Cool, A. M.; Anderson, J.; Edmonds, P. D.; Davies, M. B.

    2002-12-01

    The globular cluster Omega Centauri, with its high mass and large, moderate density core, is of interest both for its population of primordial binaries and for the large number of tidal-capture and/or exchange-collision binaries it may harbor. We have obtained a 3x3 mosaic of Wide Field Camera pointings with HST's Advanced Camera for Surveys, covering a 10'x10' field out to the cluster's half-mass radius. Containing ~1.7 million detected stars, the resulting mosaic represents the most complete image of Omega Cen yet obtained. Here we report preliminary findings of a search in these data for optical counterparts to more than 100 faint X-ray sources (Lx ~ 2 x 1030 - 5 x 1032 erg-s-1) detected in our prior study of Omega Cen using the Chandra X-ray Observatory. Cluster X-ray sources are likely to consist primarily of accreting binary stars and close detached binaries with active coronae. Significant numbers of active galaxies in the background are also expected to be present. Using B, R, and H-alpha images, we are searching for optical counterparts that are H-alpha-bright and blue, as signatures of accretion in cataclysmic variables and/or quiescent low-mass X-ray binaries. Active binaries (e.g., BY Draconis stars) may appear as weaker H-alpha emitters lying on or slightly redward of the main sequence. This work is supported by NASA grant GO-9442 from the Space Telescope Science Institute.

  2. Follow Up of GW170817 and Its Electromagnetic Counterpart by Australian-Led Observing Programmes

    Science.gov (United States)

    Andreoni, I.; Ackley, K.; Cooke, J.; Acharyya, A.; Allison, J. R.; Anderson, G. E.; Ashley, M. C. B.; Baade, D.; Bailes, M.; Bannister, K.; Beardsley, A.; Bessell, M. S.; Bian, F.; Bland, P. A.; Boer, M.; Booler, T.; Brandeker, A.; Brown, I. S.; Buckley, D. A. H.; Chang, S.-W.; Coward, D. M.; Crawford, S.; Crisp, H.; Crosse, B.; Cucchiara, A.; Cupák, M.; de Gois, J. S.; Deller, A.; Devillepoix, H. A. R.; Dobie, D.; Elmer, E.; Emrich, D.; Farah, W.; Farrell, T. J.; Franzen, T.; Gaensler, B. M.; Galloway, D. K.; Gendre, B.; Giblin, T.; Goobar, A.; Green, J.; Hancock, P. J.; Hartig, B. A. D.; Howell, E. J.; Horsley, L.; Hotan, A.; Howie, R. M.; Hu, L.; Hu, Y.; James, C. W.; Johnston, S.; Johnston-Hollitt, M.; Kaplan, D. L.; Kasliwal, M.; Keane, E. F.; Kenney, D.; Klotz, A.; Lau, R.; Laugier, R.; Lenc, E.; Li, X.; Liang, E.; Lidman, C.; Luvaul, L. C.; Lynch, C.; Ma, B.; Macpherson, D.; Mao, J.; McClelland, D. E.; McCully, C.; Möller, A.; Morales, M. F.; Morris, D.; Murphy, T.; Noysena, K.; Onken, C. A.; Orange, N. B.; Osłowski, S.; Pallot, D.; Paxman, J.; Potter, S. B.; Pritchard, T.; Raja, W.; Ridden-Harper, R.; Romero-Colmenero, E.; Sadler, E. M.; Sansom, E. K.; Scalzo, R. A.; Schmidt, B. P.; Scott, S. M.; Seghouani, N.; Shang, Z.; Shannon, R. M.; Shao, L.; Shara, M. M.; Sharp, R.; Sokolowski, M.; Sollerman, J.; Staff, J.; Steele, K.; Sun, T.; Suntzeff, N. B.; Tao, C.; Tingay, S.; Towner, M. C.; Thierry, P.; Trott, C.; Tucker, B. E.; Väisänen, P.; Krishnan, V. Venkatraman; Walker, M.; Wang, L.; Wang, X.; Wayth, R.; Whiting, M.; Williams, A.; Williams, T.; Wolf, C.; Wu, C.; Wu, X.; Yang, J.; Yuan, X.; Zhang, H.; Zhou, J.; Zovaro, H.

    2017-12-01

    The discovery of the first electromagnetic counterpart to a gravitational wave signal has generated follow-up observations by over 50 facilities world-wide, ushering in the new era of multi-messenger astronomy. In this paper, we present follow-up observations of the gravitational wave event GW170817 and its electromagnetic counterpart SSS17a/DLT17ck (IAU label AT2017gfo) by 14 Australian telescopes and partner observatories as part of Australian-based and Australian-led research programs. We report early- to late-time multi-wavelength observations, including optical imaging and spectroscopy, mid-infrared imaging, radio imaging, and searches for fast radio bursts. Our optical spectra reveal that the transient source emission cooled from approximately 6 400 K to 2 100 K over a 7-d period and produced no significant optical emission lines. The spectral profiles, cooling rate, and photometric light curves are consistent with the expected outburst and subsequent processes of a binary neutron star merger. Star formation in the host galaxy probably ceased at least a Gyr ago, although there is evidence for a galaxy merger. Binary pulsars with short (100 Myr) decay times are therefore unlikely progenitors, but pulsars like PSR B1534+12 with its 2.7 Gyr coalescence time could produce such a merger. The displacement ( 2.2 kpc) of the binary star system from the centre of the main galaxy is not unusual for stars in the host galaxy or stars originating in the merging galaxy, and therefore any constraints on the kick velocity imparted to the progenitor are poor.

  3. Chronic Pancreatitis.

    Science.gov (United States)

    Stram, Michelle; Liu, Shu; Singhi, Aatur D

    2016-12-01

    Chronic pancreatitis is a debilitating condition often associated with severe abdominal pain and exocrine and endocrine dysfunction. The underlying cause is multifactorial and involves complex interaction of environmental, genetic, and/or other risk factors. The pathology is dependent on the underlying pathogenesis of the disease. This review describes the clinical, gross, and microscopic findings of the main subtypes of chronic pancreatitis: alcoholic chronic pancreatitis, obstructive chronic pancreatitis, paraduodenal ("groove") pancreatitis, pancreatic divisum, autoimmune pancreatitis, and genetic factors associated with chronic pancreatitis. As pancreatic ductal adenocarcinoma may be confused with chronic pancreatitis, the main distinguishing features between these 2 diseases are discussed. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. Chronic Pericarditis

    Science.gov (United States)

    ... surgery) and is considered subacute. Causes Usually, the cause of chronic effusive pericarditis is unknown. However, it may be caused by cancer, tuberculosis , or an underactive thyroid gland ( hypothyroidism ), and it occasionally occurs in people with chronic ...

  5. Chronic Pain

    Science.gov (United States)

    ... pain. Psychotherapy, relaxation and medication therapies, biofeedback, and behavior modification may also be employed to treat chronic pain. × ... pain. Psychotherapy, relaxation and medication therapies, biofeedback, and behavior modification may also be employed to treat chronic pain. ...

  6. AT 2017gfo: An Anisotropic and Three-component Kilonova Counterpart of GW170817

    Science.gov (United States)

    Perego, Albino; Radice, David; Bernuzzi, Sebastiano

    2017-12-01

    The detection of a kilo/macronova electromagnetic counterpart (AT 2017gfo) of the first gravitational-wave signal compatible with the merger of two neutron stars (GW170817) has confirmed the occurrence of r-process nucleosynthesis in this kind of event. The blue and red components of AT 2017gfo have been interpreted as the signature of multi-component ejecta in the merger dynamics. However, the explanation of AT 2017gfo in terms of the properties of the ejecta and of the ejection mechanisms is still incomplete. In this work, we analyze AT 2017gfo with a new semi-analytic model of kilo/macronova inferred from general-relativistic simulations of the merger and long-term numerical models of the merger aftermath. The model accounts for the anisotropic emission from the three known mass ejecta components: dynamic, winds, and secular outflows from the disk. The early multi-band light curves of AT 2017gfo can only be explained by the presence of a relatively low-opacity component of the ejecta at high latitudes. This points to the key role of weak interactions in setting the ejecta properties and determining the nucleosynthetic yields. Our model also constrains the total ejected mass associated to AT 2017gfo to be between 0.042 and 0.077 {M}⊙ , the observation angle of the source to be between π /12 and 7π /36, and the mass of the disk to be ≳ 0.08 {M}⊙ .

  7. Moringa oleifera Root Induces Cancer Apoptosis more Effectively than Leave Nanocomposites and Its Free Counterpart

    Science.gov (United States)

    Abd-Rabou, Ahmed A; Abdalla, Aboelfetoh M; Ali, Naglaa A; Zoheir, Khairy MA

    2017-01-01

    Medicinal plants are important elements of indigenous medical system that have persisted in developing countries. Many of the botanical chemo-preventions currently used as potent anticancer agents. However, some important anticancer agents are still extracted from plants because they cannot be synthesized chemically on a commercial scale due to their complex structures that often contain several chiral centers. The aim of this study was to test different extracts from the Moringa oleifera leaves (ML), its PLGA-CS-PEG nanocomposites (MLn), as well as root core (Rc) and outer (Ro) parts for activity against hepatocarcinoma HepG2, breast MCF7, and colorectal HCT 116/ Caco-2 cells in vitro. Nano-composites were prepared and characterized. Then, the nanocomposites and the free counterparts were screened on different propagated cancer cell lines. The underlying cytotoxic impact was followed using apoptosis measurements. All extracts kill the different cancer cells with different ratios, but intriguingly, the root core extract could kill the majority of cancer cells (approximately 70-80%), while sparing normal BHK-21 cells with minimal inhibitory effect (approximately 30-40%). Apoptotic cell increment came to confirm the cytotoxic effects of these extracts on HCT 116 cells (Rc: 212% and Ro: 180%, respectively) and HepG2 cells (ML: 567.5% and MLn: 608%, respectively) compared to control (100%) mechanistically wise. Moringa oleifera nanocomposites may have potential for use as a natural source of anti-cancer compounds. PMID:28843248

  8. Do Asian women do as well as their Caucasian counterparts in IVF treatment: Cohort study.

    Science.gov (United States)

    Kan, Andrew; Leung, Peter; Luo, Kehui; Fay, Louise; Tan, Chunyan Leeann

    2015-06-01

    To evaluate if there is a difference in pregnancy rate between Asian and Caucasian women when they undergo in vitro fertilization (IVF). This was a retrospective cohort study set in a private reproductive medicine clinic. The study consisted of a total of 2594 patients (Asian, n = 522; Caucasian, n = 2072) undergoing IVF managed by a single doctor over a 10 year period. The main outcome measures were clinical pregnancy rate and live birth rate. Logistic regression was used to control for confounding factors. Asian women achieved a significantly lower clinical pregnancy and live birth rate than their Caucasian counterparts, despite replacement of more embryos. This difference was not significant after controlling for age and duration of infertility. Despite higher doses of gonadotrophin, they achieved fewer oocytes and had resultant fewer embryos for transfer or cryopreservation. In a study designed to reduce the effect of confounding factors by looking at a large number of patients from a single IVF unit under the care of a single doctor, there does not appear to be a difference in IVF pregnancy rate as a result of race. Asian women tend to present for IVF treatment at a later age after having tried for a longer period of time and this contributes significantly to their lower pregnancy rate. © 2014 The Authors. Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology.

  9. iPTF SEARCH FOR AN OPTICAL COUNTERPART TO GRAVITATIONAL-WAVE TRANSIENT GW150914

    Energy Technology Data Exchange (ETDEWEB)

    Kasliwal, M. M.; Cao, Y.; Barlow, T.; Bellm, E.; Cook, D.; Duggan, G. E.; Kulkarni, S. R.; Lunnan, R. [Cahill Center for Astrophysics, California Institute of Technology, Pasadena, CA 91125 (United States); Cenko, S. B.; Singer, L. P. [Astrophysics Science Division, NASA Goddard Space Flight Center, Code 661, Greenbelt, MD 20771 (United States); Corsi, A.; Palliyaguru, N. [Texas Tech University, Physics Department, Lubbock, TX 79409-1051 (United States); Bhalerao, V. [Inter-University Centre for Astronomy and Astrophysics (IUCAA), Post Bag 4, Ganeshkhind, Pune 411007 (India); Ferretti, R. [The Oskar Klein Centre, Department of Physics, Stockholm University, SE-106 91 Stockholm (Sweden); Frail, D. A. [National Radio Astronomy Observatory, Socorro, NM (United States); Horesh, A.; Manulis, I. [Department of Particle Physics and Astrophysics, Weizmann Institute of Science, 76100 Rehovot (Israel); Kendrick, R. [Lockheed Martin Space Systems Company, Palo Alto, CA (United States); Laher, R. [Spitzer Science Center, California Institute of Technology, M/S 314-6, Pasadena, CA 91125 (United States); Masci, F. [Infrared Processing and Analysis Center, California Institute of Technology, Pasadena, CA 91125 (United States); and others

    2016-06-20

    The intermediate Palomar Transient Factory (iPTF) autonomously responded to and promptly tiled the error region of the first gravitational-wave event GW150914 to search for an optical counterpart. Only a small fraction of the total localized region was immediately visible in the northern night sky, due both to Sun-angle and elevation constraints. Here, we report on the transient candidates identified and rapid follow-up undertaken to determine the nature of each candidate. Even in the small area imaged of 126 deg{sup 2}, after extensive filtering, eight candidates were deemed worthy of additional follow-up. Within two hours, all eight were spectroscopically classified by the Keck II telescope. Curiously, even though such events are rare, one of our candidates was a superluminous supernova. We obtained radio data with the Jansky Very Large Array and X-ray follow-up with the Swift satellite for this transient. None of our candidates appear to be associated with the gravitational-wave trigger, which is unsurprising given that GW150914 came from the merger of two stellar-mass black holes. This end-to-end discovery and follow-up campaign bodes well for future searches in this post-detection era of gravitational waves.

  10. Intramuscular keratocyst as a soft tissue counterpart of keratocystic odontogenic tumor: differential diagnosis by immunohistochemistry.

    Science.gov (United States)

    Abé, Tatsuya; Maruyama, Satoshi; Yamazaki, Manabu; Essa, Ahmed; Babkair, Hamzah; Mikami, Toshihiko; Shingaki, Susumu; Kobayashi, Tadaharu; Hayashi, Takafumi; Cheng, Jun; Saku, Takashi

    2014-01-01

    Keratocystic odontogenic tumor (KCOT), a developmental jaw cyst previously referred to as odontogenic keratocyst (OKC), typically arises in the jawbone. In this article, however, we report a case of KCOT located within the temporalis muscle. We compared its immunohistochemical profiles with those of authentic jaw KCOT, orthokeratinized odontogenic cyst, and epidermoid cyst in order to consider whether a soft tissue counterpart of KCOT could be a separate disease entity. The patient was a 46-year-old man with a well-defined cystic lesion within the left temporalis muscle. On computed tomographic images, the lesion was recognized as a cystic lesion, although KCOT was not included in the clinical differential diagnoses. The location of the lesion was not within bone but, rather, within the temporalis muscle that was attached to the jawbones. Our review of the literature has disclosed more than 20 peripheral KCOT cases of the oral mucosa and more than 10 cases of the skin, but only 1 case arising in muscle. Immunohistochemical investigation of the present intramuscular case reveals KCOT-characteristic profiles distinct from the other 3 types of cysts investigated. The results indicate that KCOT-like lesions can arise within soft tissues, although use of the term odontogenic might seem inappropriate in those cases. © 2013.

  11. Comparing gas separation performance between all known zeolites and their zeolitic imidazolate framework counterparts.

    Science.gov (United States)

    Gómez-Álvarez, Paula; Hamad, Said; Haranczyk, Maciej; Ruiz-Salvador, A Rabdel; Calero, Sofia

    2016-01-07

    To find optimal porous materials for adsorption-based separations is a challenging task due to the extremely large number of possible pore topologies and compositions. New porous material classes such as Metal Organic Frameworks (MOFs) are emerging, and hope to replace traditionally used materials such as zeolites. Computational screening offers relatively fast searching for candidate structures as well as side-by-side comparisons between material families. This work is pioneering at examining the families comprised by the experimentally known zeolites and their respective Zeolitic Imidazolate Framework (ZIF) counterparts in the context of a number of environmental and industrial separations involving carbon dioxide, nitrogen, methane, oxygen, and argon. Additionally, unlike related published work, here all the targeted structures have been previously relaxed through energy minimization. On the first level of characterization, we considered a detailed pore characterization, identifying 24 zeolites as promising candidates for gas separation based on adsorbate sizes. The second level involved interatomic potential-based calculations to assess the adsorption performance of the materials. We found no correlation in the values of heat of adsorption between zeolites and ZIFs sharing the same topology. A number of structures were identified as potential experimental targets for CO2/N2, and CO2/CH4 affinity-based separations.

  12. Experiment data report for semiscale Mod-1 Test S-06-5. (LOFT counterpart test)

    International Nuclear Information System (INIS)

    1977-06-01

    Recorded test data are presented for Test S-06-5 of the Semiscale Mod-1 LOFT counterpart test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-06-5 was conducted from initial conditions of 2272 psia and 536 0 F to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the broken loop cold leg piping. During the test, cooling water was injected into the cold legs of the intact and broken loops to simulate emergency core coolant injection in a PWR. The purpose of Test S-06-5 was to assess the influence of the break nozzle geometry on core thermal and system response and on the subcooled and low quality mass flow rates at the break locations

  13. VERY LONG BASELINE INTERFEROMETRY SEARCH FOR THE RADIO COUNTERPART OF HESS J1943+213

    Energy Technology Data Exchange (ETDEWEB)

    Gabanyi, K. E. [Konkoly Observatory, Research Centre for Astronomy and Earth Sciences of the Hungarian Academy of Sciences, P.O. Box 67, Budapest H-1525 (Hungary); Dubner, G.; Giacani, E. [Instituto de Astronomia y Fisica del Espacio (CONICET-UBA), CC 67, Suc. 28, 1428 Buenos Aires (Argentina); Paragi, Z.; Pidopryhora, Y. [Joint Institute for VLBI in Europe, Postbus 2, 7990 AA Dwingeloo (Netherlands); Frey, S., E-mail: gabanyi@konkoly.hu [FOeMI Satellite Geodetic Observatory, P.O. Box 585, H-1592 Budapest (Hungary)

    2013-01-01

    HESS J1943+213, a TeV point source close to the Galactic plane recently discovered by the H.E.S.S. Collaboration, was proposed to be an extreme BL Lacertae object, though a pulsar wind nebula (PWN) nature could not be completely discarded. To investigate its nature, we performed high-resolution radio observations with the European Very Long Baseline Interferometry Network (EVN) and reanalyzed archival continuum and H I data. The EVN observations revealed a compact radio counterpart of the TeV source. The low brightness temperature and the resolved nature of the radio source are indications against the beamed BL Lacertae hypothesis. The radio/X-ray source appears immersed in a {approx}1' elliptical feature, suggesting a possible galactic origin (PWN nature) for the HESS source. We found that HESS J1943+213 is located in the interior of a {approx}1 Degree-Sign diameter H I feature and explored the possibility of them being physically related.

  14. Phylogenetic comparisons of a coastal bacterioplankton community with its counterparts in open ocean and freshwater systems.

    Science.gov (United States)

    Rappé; Vergin; Giovannoni

    2000-09-01

    In order to extend previous comparisons between coastal marine bacterioplankton communities and their open ocean and freshwater counterparts, here we summarize and provide new data on a clone library of 105 SSU rRNA genes recovered from seawater collected over the western continental shelf of the USA in the Pacific Ocean. Comparisons to previously published data revealed that this coastal bacterioplankton clone library was dominated by SSU rRNA gene phylotypes originally described from surface waters of the open ocean, but also revealed unique SSU rRNA gene lineages of beta Proteobacteria related to those found in clone libraries from freshwater habitats. beta Proteobacteria lineages common to coastal and freshwater samples included members of a clade of obligately methylotrophic bacteria, SSU rRNA genes affiliated with Xylophilus ampelinus, and a clade related to the genus Duganella. In addition, SSU rRNA genes were recovered from such previously recognized marine bacterioplankton SSU rRNA gene clone clusters as the SAR86, SAR11, and SAR116 clusters within the class Proteobacteria, the Roseobacter clade of the alpha subclass of the Proteobacteria, the marine group A/SAR406 cluster, and the marine Actinobacteria clade. Overall, these results support and extend previous observations concerning the global distribution of several marine planktonic prokaryote SSU rRNA gene phylotypes, but also show that coastal bacterioplankton communities contain SSU rRNA gene lineages (and presumably bacterioplankton) shown previously to be prevalent in freshwater habitats.

  15. Comparative evaluation of corrosion behaviour of type K thin film thermocouple and its bulk counterpart

    International Nuclear Information System (INIS)

    Mukherjee, S.K.; Barhai, P.K.; Srikanth, S.

    2011-01-01

    Highlights: → Anodic vacuum arc deposited chromel and alumel films are more 'noble' in 5% NaCl solution than their respective wires. → Chromel undergoes localised corrosion while alumel shows uniform corrosion. → Virgin samples of chromel-alumel TFTCs exhibit good thermoelectric response. → Their thermoelectric outputs remain largely unaffected when shelved under normal atmospheric conditions. → After 288 h of exposure in salt spray environment, their thermoelectric outputs show noticeable change due to size effects. - Abstract: This paper investigates the corrosion behaviour of type K thermoelements and their thin films, and compares the performance of chromel-alumel thin film thermocouple with its wire counterpart before and after exposure to 5% NaCl medium. Potentiodynamic polarisation tests reveal that chromel and alumel films are more 'noble' than their respective wires. Alumel corrodes faster when coupled with chromel in films than as wires. Secondary electron micrographs and electrochemical impedance spectroscopy measurements suggest that chromel shows localised corrosion while alumel undergoes uniform corrosion. Corrosion adversely affects the thermocouple output and introduces an uncertainty in the measurement.

  16. UPTF test 21D counterpart test in the MIDAS test facility

    International Nuclear Information System (INIS)

    Yoon, B. C.; Ah, D. J.; Joo, I. C.; Kwon, T. S.; Park, W. M.; Song, C. H.

    2002-01-01

    This paper describes the experimental results of UPTF Test 21D counterpart tests in the downcomer during the late reflood phase of LBLOCA. The experiments have been performed in the MIDAS test facility using superheated steam and water. The test condition was determined,based on the test results of UPTF Test 21D, by applying the 'modified linear scaling method of 1/4.077 length scale. The tests of ECC direct bypass and void height are performed separately to estimate each phenomena quantitatively. The tests were carried out by varying the injection steam flow rate of intact cold legs widely to investigate the effect of steam flow rate on the direct bypass fraction and void height. In the tests, separate effect tests have been performed in cases of DVI-1,DVI- 2 and DVI-1 and 2 injections to see the direct bypass fraction according to the DVI nozzle combination. From the tests, we found that the fraction of direct ECC bypass and the void height observed in the MIDAS test facility reasonably well agree with those of UPTF test 21- D. It confirms that the applied 'modified linear scaling law' reproduces major thermal hydraulics phenomena in the downcomer during the LBLOCA reflood phase

  17. Elaboration of a guideline for counterpart testing of integral loop systems

    International Nuclear Information System (INIS)

    Karwat, H.

    1988-01-01

    A previous study on the problems of scaling and extrapolation of experimental results indicated the necessity to overcome some uncertainty in the achievable code accuracy when applied to full size reactor systems. The empirical approach in simulating interfacial relationships within systems behaviour codes in combination with the liberty of nodalisation requires a careful assessment of the overall validity of the code verification concept. Several new test facilities are presently under construction to study fluid-dynamic effects of interest for the behaviour of PWRs under small break LOCA conditions in a larger dimension and with somewhat modified scaling considerations. The test results expected from these new facilities may be useful to assess the overall validity of the analytical simulation concept of the applied computer codes. Test facilities of interest within the European Community are the - LOBI Test Facility (vol. scaling 1/700) at JRC-Ispra - SPES Test Facility (vol. scaling 1/425) in Italy - BETHSY Facility (vol scaling 1/100) in France and outside Europe the - ROSA IV Facility (vol. scaling 1/50) in Japan. Main objective of the study was the elaboration of a guideline for the particular requirements of meaningful counterpart testing with the final aim to qualify the overall validity of code simulation concepts and the expected predictive accuracy of code applications for full size prototype PWRs

  18. THE SOCIALIST YOUTH UNION (1957–1976 – POLISH COUNTERPART OF KOMSOMOL

    Directory of Open Access Journals (Sweden)

    Joanna Sadowska

    2016-10-01

    Full Text Available The political system of the Polish People’s Republic was modelled on the Soviet one. Polish youth organizations had the ambitions of being counterparts of Komsomol: they adopted similar work methods and tried to play a similar role in the country. The obvious differences resulted from the specificity of each country and the differences in the societies. The most deeply rooted in the memory of Poles is the Socialist Youth Union, which, being the most stable, existed for almost 20 years with nearly 1.3 million members in the early 1970s. The Union was closely connected with the Polish United Workers’ Party and it had to accomplish two main kinds of political task: to select and prepare future members of the Party, both ordinary and those in the managerial positions, and to educate the whole young generation. The Party indeed treated the organization as its agency, an office dealing with the affairs of youths. However, non-political activity of the Union (culture, entertainment, tourism, etc. was much more effective and evaluated more positively. Actually, there was much more falsehood in the Union: many members were almost completely passive and the work was often only simulated.

  19. Superatom spectroscopy and the electronic state correlation between elements and isoelectronic molecular counterparts.

    Science.gov (United States)

    Peppernick, Samuel J; Gunaratne, K D Dasitha; Castleman, A W

    2010-01-19

    Detailed in the present investigation are results pertaining to the photoelectron spectroscopy of negatively charged atomic ions and their isoelectronic molecular counterparts. Experiments utilizing the photoelectron imaging technique are performed on the negative ions of the group 10 noble metal block (i.e. Ni-, Pd-, and Pt-) of the periodic table at a photon energy of 2.33 eV (532 nm). The accessible electronic transitions, term energies, and orbital angular momentum components of the bound electronic states in the atom are then compared with photoelectron images collected for isoelectronic early transition metal heterogeneous diatomic molecules, M-X- (M = Ti,Zr,W; X = O or C). A superposition principle connecting the spectroscopy between the atomic and molecular species is observed, wherein the electronic structure of the diatomic is observed to mimic that present in the isoelectronic atom. The molecular ions studied in this work, TiO-, ZrO-, and WC- can then be interpreted as possessing superatomic electronic structures reminiscent of the isoelectronic elements appearing on the periodic table, thereby quantifying the superatom concept.

  20. Water adsorption and dissociation on Ni(110): How is it different from its close packed counterparts?

    Energy Technology Data Exchange (ETDEWEB)

    Seenivasan, H.; Tiwari, Ashwani K., E-mail: ashwani@iiserkol.ac.in [Indian Institute of Science Education and Research Kolkata, Mohanpur 741252 (India)

    2014-05-07

    Water adsorption and dissociation on Ni(110) surface is studied in detail and compared with its close packed counterparts using density functional theory calculations. Water adsorption occurs on the top site as found on Ni(100) and Ni(111) but the adsorption is stronger on Ni(110). H and OH preferably adsorb on the short bridge sites (brgshort) opposed to hollow sites on (100) and (111) surfaces. Energy barriers for water molecule dissociation on Ni(110) as obtained from the transition state (TS) calculations were low compared to other Ni low indexed surfaces. TS geometries at different positions of the lattice coordinate, Q, were obtained to study the effect of surface temperature on dissociation of H{sub 2}O molecules. These calculations revealed that second layer atoms were also involved in the TS. Dissociation probabilities are obtained using a semi-classical approximation by sampling Q for a Boltzmann distribution at different temperatures. Results showed that the increasing surface temperature significantly increases the dissociation probabilities at lower energies and saturates near the barrier for dissociation. Although the contribution from both top and second layers is similar at low surface temperatures, motion of top layer atoms contribute more towards dissociation probability at higher surface temperatures. Dissociation probabilities obtained are more than one order of magnitude higher than that on Ni(100) and Ni(111) surfaces suggesting Ni(110) to be more reactive among the low indexed Ni surfaces.

  1. The cocoon emission - an electromagnetic counterpart to gravitational waves from neutron star mergers

    Science.gov (United States)

    Gottlieb, Ore; Nakar, Ehud; Piran, Tsvi

    2018-01-01

    Short gamma-ray bursts are believed to arise from compact binary mergers (either neutron star-neutron star or black hole-neutron star). If so, their jets must penetrate outflows that are ejected during the merger. As a jet crosses the ejecta, it dissipates its energy, producing a hot cocoon that surrounds it. We present here 3D numerical simulations of jet propagation in mergers' outflows, and we calculate the resulting emission. This emission consists of two components: the cooling emission, the leakage of the thermal energy of the hot cocoon, and the cocoon macronova that arises from the radioactive decay of the cocoon's material. This emission gives a brief (∼1 h) blue, wide angle signal. While the parameters of the outflow and jet are uncertain, for the configurations we have considered, the signal is bright (∼-14 to -15 absolute magnitude) and outshines all other predicted ultraviolet-optical signals. The signal is brighter when the jet breakout time is longer, and its peak brightness does not depend strongly on the highly uncertain opacity. A rapid search for such a signal is a promising strategy to detect an electromagnetic merger counterpart. A detected candidate could be then followed by deep infrared searches for the longer but weaker macronova arising from the rest of the ejecta.

  2. Identifying open magnetic field regions of the Sun and their heliospheric counterparts

    Science.gov (United States)

    Krista, L. D.; Reinard, A.

    2017-12-01

    Open magnetic regions on the Sun are either long-lived (coronal holes) or transient (dimmings) in nature. Both phenomena are fundamental to our understanding of the solar behavior as a whole. Coronal holes are the sources of high-speed solar wind streams that cause recurrent geomagnetic storms. Furthermore, the variation of coronal hole properties (area, location, magnetic field strength) over the solar activity cycle is an important marker of the global evolution of the solar magnetic field. Dimming regions, on the other hand, are short-lived coronal holes that often emerge in the wake of solar eruptions. By analyzing their physical properties and their temporal evolution, we aim to understand their connection with their eruptive counterparts (flares and coronal mass ejections) and predict the possibility of a geomagnetic storm. The author developed the Coronal Hole Automated Recognition and Monitoring (CHARM) and the Coronal Dimming Tracker (CoDiT) algorithms. These tools not only identify but track the evolution of open magnetic field regions. CHARM also provides daily coronal hole maps, that are used for forecasts at the NOAA Space Weather Prediction Center. Our goal is to better understand the processes that give rise to eruptive and non-eruptive open field regions and investigate how these regions evolve over time and influence space weather.

  3. “The Scum of the Earth”? Foreign People Smugglers and Their Local Counterparts in Indonesia

    Directory of Open Access Journals (Sweden)

    Antje Missbach

    2011-01-01

    Full Text Available Since 2008, the number of asylum seekers and refugees trying to reach Australia from Indonesia by boat has increased. With many of them hailing from conflict-ridden countries such as Afghanistan, Iraq and Sri Lanka, most entered Indonesia with short-term tourist visas or fraudulent papers or no documents at all. It is widely known that a significant number of these ‘irregular’ migrants pay various types of brokers (often labelled, accurately or otherwise, ‘human smugglers’ at least at one stage – either to enter the country or to escape it. As a non-signatory to the UN Refugee Convention, Indonesia does not permit local integration. While a substantial part of these migrants are detained in the 13 immigration detention centres scattered around the archipelago, many roam freely, looking for opportunities for onward migration. Due to the restrictive border protection arrangements between Australia and Indonesia and a number of bilateral intelligence measures for deterring ‘unwanted’ migrants, human smugglers have been gradually forced to adapt strategies, routes and prices. According to much of the available data, most human smugglers are not Indonesians but foreigners who have been lingering in Indonesia for many years. This article demonstrates, moreover, that these foreigners depend upon local contacts to successfully carry out their risky business. Most often, the Indonesian counterparts are solely facilitators or handymen, but in a number of cases Indonesian authorities have also been involved in this highly lucrative business.

  4. Access and Social Capital: A Profile of Community College and Global Counterparts

    Directory of Open Access Journals (Sweden)

    Rosalind Latiner Raby

    2014-12-01

    Full Text Available Alternatives to the traditional four-year public and private university include a sector of higher education that offers a more advanced curriculum than secondary school and serves as a local and often lower-cost pathway that gives options for university overflow for adult learners, displaced workers, life-long learners, workforce learners, developmental learners, and non-traditional learners (Raby and Valeau 2009. These institutional types are known by several names including College of Further Education, Community College, Polytechnic, Technical College, and Technical and Further Education (TAFE and are found on all continents. Based on a literature review of 1,083 academic publications these institutions share a mission that views educational access as necessary for growing the economic and social capital that is needed to help students improve lives. Central to this mission is the belief that any amount of post-secondary education is life-enhancing, regardless of length of study or level of completion. This article examines application of this mission at community colleges and global counterparts throughout the world.

  5. A Search for High-Energy Counterparts to Fast Radio Bursts

    Science.gov (United States)

    Cunningham, Virginia A.; Cenko, Bradley

    2018-01-01

    We report on a search for high-energy counterparts to Fast Radio Bursts (FRBs) with the Fermi Gamma-ray Burst Monitor (GBM), Fermi Large Area Telescope (LAT), and the Swift Burst Alert Telescope (BAT). We find no significant associations for any of the 14 FRBs in our sample, but report upper limits to the high-energy fluence for each on timescales of ∼0.1, 1, 10, and 100 s. We report lower limits on the radio to high-energy fluence, fr / fγ, for timescales of ∼0.1 and 100 s. The non-detection of high-energy emission is expected if FRBs are analogous to the giant pulses seen from the Crab pulsar, but the observed radio fluences of FRBs are orders of magnitude larger than even the most extreme giant pulses would be at the implied cosmological distances. It has also been proposed that events similar to magnetar hyperflares produce FRBs; this might be a viable model, but our fr / fγ lower limits are in tension with the fr / fγ upper limit for the 2004 superburst of SGR 1806‑20, for 6 out of the 12 FRBs that we study. This demonstrates the utility of analyses of high-energy data for FRBs in tracking down the nature of these elusive sources.

  6. X-ray counterpart candidates for six new γ-ray pulsars

    Science.gov (United States)

    Zyuzin, Dmitry A.; Karpova, Anna V.; Shibanov, Yuriy A.

    2018-05-01

    Using archival X-ray data, we have found point-like X-ray counterpart candidates positionally coincident with six γ-ray pulsars discovered recently in the Fermi Gamma-ray Space Telescope data by the Einstein@Home project. The candidates for PSRs J0002+6216, J0554+3107, J1844-0346, and J1105-6037 are detected with Swift, and those for PSRs J0359+5414 and J2017+3625 are detected with Chandra. Despite a low count statistics for some candidates, assuming plausible constraints on the absorbing column density towards the pulsars, we show that X-ray spectral properties for all of them are consistent with those observed for other pulsars. J0359+5414 is the most reliably identified object. We detect a nebula around it, whose spectrum and extent suggest that this is a pulsar wind nebula powered by the pulsar. Associations of J0002+6216 and J1844-0346 with supernova remnants CTB 1 and G28.6-0.1 are proposed.

  7. Real-time Automatic Search for Multi-wavelength Counterparts of DWF Transients

    Science.gov (United States)

    Murphy, Christopher; Cucchiara, Antonino; Andreoni, Igor; Cooke, Jeff; Hegarty, Sarah

    2018-01-01

    The Deeper Wider Faster (DWF) survey aims to find and classify the fastest transients in the Universe. DWF utilizes the Dark Energy Camera (DECam), collecting a continuous sequence of 20s images over a 3 square degree field of view.Once an interesting transient is detected during DWF observations, the DWF collaboration has access to several facilities for rapid follow-up in multiple wavelengths (from gamma to radio).An online web tool has been designed to help with real-time visual classification of possible astrophysical transients in data collected by the DWF observing program. The goal of this project is to create a python-based code to improve the classification process by querying several existing archive databases. Given the DWF transient location and search radius, the developed code will extract a list of possible counterparts and all available information (e.g. magnitude, radio fluxes, distance separation).Thanks to this tool, the human classifier can make a quicker decision in order to trigger the collaboration rapid-response resources.

  8. A Comparative Theoretical and Computational Study on Robust Counterpart Optimization: I. Robust Linear Optimization and Robust Mixed Integer Linear Optimization

    Science.gov (United States)

    Li, Zukui; Ding, Ran; Floudas, Christodoulos A.

    2011-01-01

    Robust counterpart optimization techniques for linear optimization and mixed integer linear optimization problems are studied in this paper. Different uncertainty sets, including those studied in literature (i.e., interval set; combined interval and ellipsoidal set; combined interval and polyhedral set) and new ones (i.e., adjustable box; pure ellipsoidal; pure polyhedral; combined interval, ellipsoidal, and polyhedral set) are studied in this work and their geometric relationship is discussed. For uncertainty in the left hand side, right hand side, and objective function of the optimization problems, robust counterpart optimization formulations induced by those different uncertainty sets are derived. Numerical studies are performed to compare the solutions of the robust counterpart optimization models and applications in refinery production planning and batch process scheduling problem are presented. PMID:21935263

  9. Energetic particle counterparts for geomagnetic pulsations of Pc1 and IPDP types

    Directory of Open Access Journals (Sweden)

    T. A. Yahnina

    Full Text Available Using the low-altitude NOAA satellite particle data, we study two kinds of localised variations of energetic proton fluxes at low altitude within the anisotropic zone equatorward of the isotropy boundary. These flux variation types have a common feature, i.e. the presence of precipitating protons measured by the MEPED instrument at energies more than 30 keV, but they are distinguished by the fact of the presence or absence of the lower-energy component as measured by the TED detector on board the NOAA satellite. The localised proton precipitating without a low-energy component occurs mostly in the morning-day sector, during quiet geomagnetic conditions, without substorm injections at geosynchronous orbit, and without any signatures of plasmaspheric plasma expansion to the geosynchronous distance. This precipitation pattern closely correlates with ground-based observations of continuous narrow-band Pc1 pulsations in the frequency range 0.1–2 Hz (hereafter Pc1. The precipitation pattern containing the low energy component occurs mostly in the evening sector, under disturbed geomagnetic conditions, and in association with energetic proton injections and significant increases of cold plasma density at geosynchronous orbit. This precipitation pattern is associated with geomagnetic pulsations called Intervals of Pulsations with Diminishing Periods (IPDP, but some minor part of the events is also related to narrow-band Pc1. Both Pc1 and IPDP pulsations are believed to be the electromagnetic ion-cyclotron waves generated by the ion-cyclotron instability in the equatorial plane. These waves scatter energetic protons in pitch angles, so we conclude that the precipitation patterns studied here are the particle counterparts of the ion-cyclotron waves.

    Key words. Ionosphere (particle precipitation – Magnetospheric physics (energetic particles, precipitating – Space plasma physics (wave-particle interactions

  10. Energetic particle counterparts for geomagnetic pulsations of Pc1 and IPDP types

    Directory of Open Access Journals (Sweden)

    T. A. Yahnina

    2003-12-01

    Full Text Available Using the low-altitude NOAA satellite particle data, we study two kinds of localised variations of energetic proton fluxes at low altitude within the anisotropic zone equatorward of the isotropy boundary. These flux variation types have a common feature, i.e. the presence of precipitating protons measured by the MEPED instrument at energies more than 30 keV, but they are distinguished by the fact of the presence or absence of the lower-energy component as measured by the TED detector on board the NOAA satellite. The localised proton precipitating without a low-energy component occurs mostly in the morning-day sector, during quiet geomagnetic conditions, without substorm injections at geosynchronous orbit, and without any signatures of plasmaspheric plasma expansion to the geosynchronous distance. This precipitation pattern closely correlates with ground-based observations of continuous narrow-band Pc1 pulsations in the frequency range 0.1–2 Hz (hereafter Pc1. The precipitation pattern containing the low energy component occurs mostly in the evening sector, under disturbed geomagnetic conditions, and in association with energetic proton injections and significant increases of cold plasma density at geosynchronous orbit. This precipitation pattern is associated with geomagnetic pulsations called Intervals of Pulsations with Diminishing Periods (IPDP, but some minor part of the events is also related to narrow-band Pc1. Both Pc1 and IPDP pulsations are believed to be the electromagnetic ion-cyclotron waves generated by the ion-cyclotron instability in the equatorial plane. These waves scatter energetic protons in pitch angles, so we conclude that the precipitation patterns studied here are the particle counterparts of the ion-cyclotron waves.Key words. Ionosphere (particle precipitation – Magnetospheric physics (energetic particles, precipitating – Space plasma physics (wave-particle interactions

  11. Transcriptome analysis of adiposity in domestic ducks by transcriptomic comparison with their wild counterparts.

    Science.gov (United States)

    Chen, L; Luo, J; Li, J X; Li, J J; Wang, D Q; Tian, Y; Lu, L Z

    2015-06-01

    Excessive adiposity is a major problem in the duck industry, but its molecular mechanisms remain unknown. Genetic comparisons between domestic and wild animals have contributed to the exploration of genetic mechanisms responsible for many phenotypic traits. Significant differences in body fat mass have been detected between domestic and wild ducks. In this study, we used the Peking duck and Anas platyrhynchos as the domestic breed and wild counterpart respectively and performed a transcriptomic comparison of abdominal fat between the two breeds to comprehensively analyze the transcriptome basis of adiposity in ducks. We obtained approximately 350 million clean reads; assembled 61 250 transcripts, including 23 699 novel ones; and identified alternative 5' splice sites, alternative 3' splice sites, skipped exons and retained intron as the main alternative splicing events. A differential expression analysis between the two breeds showed that 753 genes exhibited differential expression. In Peking ducks, some lipid metabolism-related genes (IGF2, FABP5, BMP7, etc.) and oncogenes (RRM2, AURKA, CYR61, etc.) were upregulated, whereas genes related to tumor suppression and immunity (TNFRSF19, TNFAIP6, IGSF21, NCF1, etc.) were downregulated, suggesting adiposity might closely associate with tumorigenesis in ducks. Furthermore, 280 576 single-nucleotide variations were found differentiated between the two breeds, including 8641 non-synonymous ones, and some of the non-synonymous ones were found enriched in genes involved in lipid-associated and immune-associated pathways, suggesting abdominal fat of the duck undertakes both a metabolic function and immune-related function. These datasets enlarge our genetic information of ducks and provide valuable resources for analyzing mechanisms underlying adiposity in ducks. © 2015 Stichting International Foundation for Animal Genetics.

  12. Independent introductions and admixtures have contributed to adaptation of European maize and its American counterparts.

    Directory of Open Access Journals (Sweden)

    Jean-Tristan Brandenburg

    2017-03-01

    Full Text Available Through the local selection of landraces, humans have guided the adaptation of crops to a vast range of climatic and ecological conditions. This is particularly true of maize, which was domesticated in a restricted area of Mexico but now displays one of the broadest cultivated ranges worldwide. Here, we sequenced 67 genomes with an average sequencing depth of 18x to document routes of introduction, admixture and selective history of European maize and its American counterparts. To avoid the confounding effects of recent breeding, we targeted germplasm (lines directly derived from landraces. Among our lines, we discovered 22,294,769 SNPs and between 0.9% to 4.1% residual heterozygosity. Using a segmentation method, we identified 6,978 segments of unexpectedly high rate of heterozygosity. These segments point to genes potentially involved in inbreeding depression, and to a lesser extent to the presence of structural variants. Genetic structuring and inferences of historical splits revealed 5 genetic groups and two independent European introductions, with modest bottleneck signatures. Our results further revealed admixtures between distinct sources that have contributed to the establishment of 3 groups at intermediate latitudes in North America and Europe. We combined differentiation- and diversity-based statistics to identify both genes and gene networks displaying strong signals of selection. These include genes/gene networks involved in flowering time, drought and cold tolerance, plant defense and starch properties. Overall, our results provide novel insights into the evolutionary history of European maize and highlight a major role of admixture in environmental adaptation, paralleling recent findings in humans.

  13. Optical Counterparts for Low-Luminosity X-ray Sources in Omega Centauri

    Science.gov (United States)

    Cool, Adrienne

    2002-07-01

    We propose to use narrow-band HAlpha imaging with ACS to search for the optical counterparts of low-luminosity X-ray sources {Lx 2 x 10^30 - 5 x 10^32 erg/s} in the globular cluster Omega Centauri. With 9 WFC fields, we will cover the inner two core radii of the cluster, and encompass about 90 of the faint sources we have identified with Chandra. Approximately 30-50 of these sources should be cluster members, the remainder being mostly background galaxies plus a smaller number of foreground stars. This large population of low-Lx cluster X-ray sources is second only to the more than 100 faint sources recently discovered in 47 Tuc with Chandra {Grindlay et al. 2001a}, which have been identified as a mixture of cataclysmic variables, quiescent low-mass X-ray binaries, millisecond pulsars, and coronally active main-sequence binaries. Our Cycle 6 WFPC2 program successfully identified 2 of the 3 then-known faint X-ray sources in the core of Omega Cen using H-alpha imaging. We now propose to expand the areal coverage by a factor of about 18 to encompass the much larger number of sources that have since been discovered with Chandra. The extreme crowding in the central regions of Omega Cen requires the resolution of HST to obtain optical IDs. These identifications are key to making meaningful comparisons between the populations of faint X-ray sources in different clusters, in an effort to understand their origins and role in cluster dynamics.

  14. Reversal of functional disorders by aspiration, expiration and cough reflexes and their voluntary counterparts

    Directory of Open Access Journals (Sweden)

    Zoltan eTomori

    2012-12-01

    Full Text Available Agonal gasping provoked by asphyxia can save ~15% of mammals even from untreated ventricular fibrillation, but it fails to revive infants with sudden infant death syndrome. Our systematic study of airway reflexes in cats and other animals indicated that in addition to cough, there are 2 distinct airway reflexes that may contribute to auto-resuscitation. Gasp- and sniff-like spasmodic inspirations can be elicited by nasopharyngeal stimulation, strongly activating the brainstem generator for inspiration, which is also involved in the control of gasping. This aspiration reflex (AspR is characterized by spasmodic inspiration without subsequent active expiration and can be elicited during agonal gasping, caused by brainstem trans-sections in cats. Stimulation of the larynx can activate the generator for expiration to evoke the expiration reflex, manifesting with prompt expiration without preceding inspiration. Stimulation of the oro-pharynx and lower airways provokes the cough reflex which results from activating of both generators. The powerful potential of the AspR resembling auto-resuscitation by gasping can influence the control mechanisms of vital functions, mediating reversal of various functional disorders.The AspR in cats interrupted hypoxic apnea, laryngo- and bronchospasm, apneusis and even transient asphyxic coma, and can normalize various hypo- and hyper-functional disorders. Introduction of a nasogastric catheter evoked similar spasmodic inspirations in premature infants and interrupted hiccough attacks in adults. Coughing on demand can prevent anaphylactic shock and resuscitate the pertinent subject. Sniff representing nasal inspiratory pressure and maximal inspiratory and expiratory pressures are voluntary counterparts of airway reflexes, and are useful for diagnosis and therapy of various cardio-respiratory and neuromuscular disorders.

  15. Multiband counterparts of two eclipsing ultraluminous X-ray sources in M 51

    Science.gov (United States)

    Urquhart, R.; Soria, R.; Johnston, H. M.; Pakull, M. W.; Motch, C.; Schwope, A.; Miller-Jones, J. C. A.; Anderson, G. E.

    2018-04-01

    We present the discovery and interpretation of ionized nebulae around two ultraluminous X-ray sources in M 51; both sources share the rare property of showing X-ray eclipses by their companion stars and are therefore prime targets for follow-up studies. Using archival Hubble Space Telescope images, we found an elongated, 100-pc-long emission-line structure associated with one X-ray source (CXOM51 J132940.0+471237; ULX-1 for simplicity), and a more circular, ionized nebula at the location of the second source (CXOM51 J132939.5+471244; ULX-2 for simplicity). We observed both nebulae with the Large Binocular Telescope's Multi-Object Double Spectrograph. From our analysis of the optical spectra, we argue that the gas in the ULX-1 bubble is shock-ionized, consistent with the effect of a jet with a kinetic power of ≈2 × 1039 erg s-1. Additional X-ray photoionization may also be present, to explain the strength of high-ionization lines such as He II λ4686 and [Ne V] λ3426. On the other hand, the emission lines from the ULX-2 bubble are typical for photoionization by normal O stars suggesting that the nebula is actually an H II region not physically related to the ULX but is simply a chance alignment. From archival Very Large Array data, we also detect spatially extended, steep-spectrum radio emission at the location of the ULX-1 bubble (consistent with its jet origin), but no radio counterpart for ULX-2 (consistent with the lack of shock-ionized gas around that source).

  16. THE X-RAY COUNTERPART OF THE HIGH-B PULSAR PSR J0726–2612

    International Nuclear Information System (INIS)

    Speagle, J. S.; Kaplan, D. L.; Van Kerkwijk, M. H.

    2011-01-01

    Middle-aged, cooling neutron stars are observed both as relatively rapidly spinning radio pulsars and as more slowly spinning, strongly magnetized isolated neutron stars (INSs), which stand out by their thermal X-ray spectra. The difference between the two classes may be that the INSs initially had much stronger magnetic fields, which decayed. To test this, we used the Chandra X-ray Observatory to observe 1RXS J072559.8–261229, a possible X-ray counterpart to PSR J0726–2612, which, with its 3.44 s period and 3 × 10 13 G inferred magnetic field strength, is the nearest and least extincted among the possible slowly spinning, strong-field INS progenitors (it likely is in the Gould Belt, at ∼1 kpc). We confirm the identification and find that the pulsar has a spectrum consistent with being purely thermal, with blackbody temperature kT = 87 ± 5 eV and radius R = 5.7 +2.6 –1.3 km at a distance of 1 kpc. We detect sinusoidal pulsations at twice the radio period with a semi-amplitude of 27% ± 5%. The properties of PSR J0726–2612 strongly resemble those of the INSs, except for its much shorter characteristic age of 200 kyr (instead of several Myr). We conclude that PSR J0726–2612 is indeed an example of a young INS, one that started with a magnetic field strength on the low end of those inferred for the INSs, and that, therefore, decayed by a relatively small amount. Our results suggest that the long-period, strong-field pulsars and the INSs are members of the same class, and open up new opportunities to understand the puzzling X-ray and optical emission of the INSs through radio observations of PSR J0726–2612.

  17. THE X-RAY COUNTERPART OF THE HIGH-B PULSAR PSR J0726-2612

    Energy Technology Data Exchange (ETDEWEB)

    Speagle, J. S.; Kaplan, D. L. [Physics Department, University of Wisconsin-Milwaukee, Milwaukee, WI 53211 (United States); Van Kerkwijk, M. H., E-mail: kaplan@uwm.edu, E-mail: joshuaspeagle@college.harvard.edu, E-mail: mhvk@astro.utoronto.ca [Department of Astronomy and Astrophysics, University of Toronto, 60 St. George Street, Toronto, ON M5S 3H8 (Canada)

    2011-12-20

    Middle-aged, cooling neutron stars are observed both as relatively rapidly spinning radio pulsars and as more slowly spinning, strongly magnetized isolated neutron stars (INSs), which stand out by their thermal X-ray spectra. The difference between the two classes may be that the INSs initially had much stronger magnetic fields, which decayed. To test this, we used the Chandra X-ray Observatory to observe 1RXS J072559.8-261229, a possible X-ray counterpart to PSR J0726-2612, which, with its 3.44 s period and 3 Multiplication-Sign 10{sup 13} G inferred magnetic field strength, is the nearest and least extincted among the possible slowly spinning, strong-field INS progenitors (it likely is in the Gould Belt, at {approx}1 kpc). We confirm the identification and find that the pulsar has a spectrum consistent with being purely thermal, with blackbody temperature kT = 87 {+-} 5 eV and radius R = 5.7{sup +2.6}{sub -1.3} km at a distance of 1 kpc. We detect sinusoidal pulsations at twice the radio period with a semi-amplitude of 27% {+-} 5%. The properties of PSR J0726-2612 strongly resemble those of the INSs, except for its much shorter characteristic age of 200 kyr (instead of several Myr). We conclude that PSR J0726-2612 is indeed an example of a young INS, one that started with a magnetic field strength on the low end of those inferred for the INSs, and that, therefore, decayed by a relatively small amount. Our results suggest that the long-period, strong-field pulsars and the INSs are members of the same class, and open up new opportunities to understand the puzzling X-ray and optical emission of the INSs through radio observations of PSR J0726-2612.

  18. Life-cycle Analysis of Bioproducts and Their Conventional Counterparts in GREET

    Energy Technology Data Exchange (ETDEWEB)

    Dunn, Jennifer B. [Argonne National Lab. (ANL), Argonne, IL (United States); Adom, Felix [Argonne National Lab. (ANL), Argonne, IL (United States); Sather, Norm [Argonne National Lab. (ANL), Argonne, IL (United States); Han, Jeongwoo [Argonne National Lab. (ANL), Argonne, IL (United States); Snyder, Seth [Argonne National Lab. (ANL), Argonne, IL (United States); He, Chang [Northwestern Univ., Evanston, IL (United States); Gong, Jian [Northwestern Univ., Evanston, IL (United States); Yue, Dajun [Northwestern Univ., Evanston, IL (United States); You, Fengqi [Northwestern Univ., Evanston, IL (United States)

    2015-09-01

    To further expand upon the literature in this field and to develop a platform for bioproduct LCA, we developed LCA results for ten bioproducts produced either from algal glycerol or from corn stover-derived sugars. We used Argonne National Laboratory’s Greenhouse gases, Regulated Emissions, and Energy use in Transportation (GREETTM) model as the platform for this study. The data and calculations reported herein are available to GREET users in a bioproducts module included in the fall 2015 GREET release. This report documents our approach to this analysis and the results. In Chapter 2, we review the process we underwent to select the bioproducts for analysis based on market and technology readiness criteria. In Chapter 3, we review key parameters for production of the two feedstocks we considered: corn stover and algae. Given the lack of publicly available information about the production of bioproducts, which is caused in large part by the emerging nature of the industry, we developed Aspen Plus® simulations of the processes that could be used to produce each bioproduct. From these simulations, we extracted the energy and material flows of these processes, which were important inputs to the GREET bioproducts module. Chapter 4 provides the details of these Aspen Plus simulations. It is important to compare the LCA results for bioproducts to those for their petroleum counterparts. We therefore also developed material and energy flow data for conventional products based mostly on the literature. These data are described in Chapter 5 and are also included in the GREET bioproducts module. In Chapter 6, we present results from this analysis and examine areas for refinement and future research.

  19. Microbiological profile of chronic suppurative otits media among HIV ...

    African Journals Online (AJOL)

    Background: Immune compromised HIV/AIDS infected children have consistently shown a higher prevalence of chronic suppurative otitis media than their immune competent counterparts.This study aimed to compare the microbial isolates from ear discharges in HIV infected and non infected children. Method: This was a ...

  20. Search for the NIR counterpart to GRB130807A/SWIFTJ1759.2-2736 in quiescence

    NARCIS (Netherlands)

    Greiss, S.; Steeghs, D.; Jonker, P.G.; Maccarone, T.; Torres, M.A.P.; Heinke, C.; Wijnands, R.

    2013-01-01

    In order to search for the counterpart of the transient source SWIFTJ1759.2-2736 (Atel #5268), we investigated near-infrared (NIR) data of the Galactic Bulge region obtained as part of the VVV survey (Minniti et al. 2010, New Astronomy, Volume 15, 433). The observations took place while the source

  1. The second Herschel-ATLAS Data Release - III. Optical and near-infrared counterparts in the North Galactic Plane field

    Science.gov (United States)

    Furlanetto, C.; Dye, S.; Bourne, N.; Maddox, S.; Dunne, L.; Eales, S.; Valiante, E.; Smith, M. W.; Smith, D. J. B.; Ivison, R. J.; Ibar, E.

    2018-05-01

    This paper forms part of the second major public data release of the Herschel Astrophysical Terahertz Large Area Survey (H-ATLAS). In this work, we describe the identification of optical and near-infrared counterparts to the submillimetre detected sources in the 177 deg2 North Galactic Plane (NGP) field. We used the likelihood ratio method to identify counterparts in the Sloan Digital Sky Survey and in the United Kingdom InfraRed Telescope Imaging Deep Sky Survey within a search radius of 10 arcsec of the H-ATLAS sources with a 4σ detection at 250 μm. We obtained reliable (R ≥ 0.8) optical counterparts with r performance of the likelihood ratio method to identify optical and near-infrared counterparts taking into account the depth and area of both input catalogues. Using catalogues with the same surface density of objects in the overlapping ˜25 deg2 area, we obtained that the reliable fraction in the near-infrared (54.8 per cent) is significantly higher than in the optical (36.4 per cent). Finally, using deep radio data which covers a small region of the NGP field, we found that 80-90 per cent of our reliable identifications are correct.

  2. Aggression as a Motive for Gossip During Conflict : The Role of Power, Social Value Orientation, and Counterpart's Behavior

    NARCIS (Netherlands)

    Jeuken, E.; Beersma, B.; ten Velden, F.S.; Dijkstra, M.T.M.

    Not much is known about the motives behind the use of gossip in conflict situations. We report a laboratory experiment that examined the influence of social value orientation, counterpart's behavior, and power on the motive to use gossip for indirect aggression in a conflict situation. Results

  3. Aggression as a motive for gossip during conflict: The role of power, social value orientation, and counterpart's behavior

    NARCIS (Netherlands)

    Jeuken, A. E.; Beersma, B.; Ten Velden, F.S.; Dijkstra, M.T.M.

    2015-01-01

    Not much is known about the motives behind the use of gossip in conflict situations. We report a laboratory experiment that examined the influence of social value orientation, counterpart's behavior, and power on the motive to use gossip for indirect aggression in a conflict situation. Results

  4. THE SUB-mJy RADIO POPULATION OF THE E-CDFS: OPTICAL AND INFRARED COUNTERPART IDENTIFICATION

    Energy Technology Data Exchange (ETDEWEB)

    Bonzini, M.; Mainieri, V.; Padovani, P.; Rosati, P. [ESO, Karl-Schwarzschild-Strasse 2, D-85748 Garching (Germany); Kellermann, K. I. [National Radio Astronomy Observatory, 520 Edgemont Road, Charlottesville, VA 22903-2475 (United States); Miller, N. [Department of Astronomy, University of Maryland, College Park, MD 20742-2421 (United States); Tozzi, P.; Balestra, I. [INAF Osservatorio Astronomico di Trieste, via G.B. Tiepolo 11, I-34131, Trieste (Italy); Vattakunnel, S. [Dipartimento di Fisica Universit di Trieste, piazzale Europa 1, I-34127 Trieste (Italy); Brandt, W. N.; Luo, B. [Department of Astronomy and Astrophysics, Pennsylvania State University, University Park, PA 16802 (United States); Xue, Y. Q., E-mail: mbonzini@eso.org [Key Laboratory for Research in Galaxies and Cosmology, Department of Astronomy, University of Science and Technology of China, Chinese Academy of Sciences, Hefei, Anhui 230026 (China)

    2012-11-15

    We study a sample of 883 sources detected in a deep Very Large Array survey at 1.4 GHz in the Extended Chandra Deep Field South. This paper focuses on the identification of their optical and infrared (IR) counterparts. We use a likelihood-ratio technique that is particularly useful when dealing with deep optical images to minimize the number of spurious associations. We find a reliable counterpart for 95% of our radio sources. Most of the counterparts (74%) are detected at optical wavelengths, but there is a significant fraction (21%) that are only detectable in the IR. Combining newly acquired optical spectra with data from the literature, we are able to assign a redshift to 81% of the identified radio sources (37% spectroscopic). We also investigate the X-ray properties of the radio sources using the Chandra 4 Ms and 250 ks observations. In particular, we use a stacking technique to derive the average properties of radio objects undetected in the Chandra images. The results of our analysis are collected in a new catalog containing the position of the optical/IR counterpart, the redshift information, and the X-ray fluxes. It is the deepest multi-wavelength catalog of radio sources, which will be used for future study of this galaxy population.

  5. The Effect of Counterpart Material on the Sliding Wear of TiAlN Coatings Deposited by Reactive Cathodic Pulverization

    Directory of Open Access Journals (Sweden)

    Michell Felipe Cano Ordoñez

    2015-11-01

    Full Text Available This work aims to study the effect of the counterpart materials (100Cr6, Al2O3 and WC-Co on the tribological properties of TiAlN thin films deposited on AISI H13 steel substrate by reactive magnetron co-sputtering. The structural characterization of the TiAlN films, performed by X-ray diffraction, showed (220 textured fcc crystalline structure. The values of hardness and elastic modulus obtained by nanoindentation were 27 GPa and 420 GPa, respectively, which resulted in films with a relatively high resistance to plastic deformation. Ball-on-disk sliding tests were performed using normal loads of 1 N and 3 N, and 0.10 m/s of tangential velocity. The wear coefficient of the films was determined by measuring the worn area using profilometry every 1000 cycles. The mechanical properties and the chemical stability of the counterpart material, debris formation and the contact stress influences the friction and the wear behavior of the studied tribosystems. Increasing the hardness of the counterpart decreases the coefficient of friction (COF due to lower counterpart material transference and tribofilm formation, which is able to support the contact pressure. High shear stress concentration at the coating/substrate interface was reported for higher load promoting failure of the film-substrate system for all tribopairs

  6. Post-test analysis of the ROSA/LSTF and PKL counterpart test

    Energy Technology Data Exchange (ETDEWEB)

    Carlos, S., E-mail: scarlos@iqn.upv.es [Departament d’Enginyeria Química i Nuclear, Universitat Politècnica de València, Camí de Vera, 14, València Spain (Spain); Querol, A., E-mail: anquevi@iqn.upv.es [Departament d’Enginyeria Química i Nuclear, Universitat Politècnica de València, Camí de Vera, 14, València Spain (Spain); Instituto de Seguridad Industrial, Radiofísica y Medioambiental, Universitat Politècnica de València, Camí de Vera, 14, València (Spain); Gallardo, S., E-mail: sergalbe@iqn.upv.es [Departament d’Enginyeria Química i Nuclear, Universitat Politècnica de València, Camí de Vera, 14, València Spain (Spain); Instituto de Seguridad Industrial, Radiofísica y Medioambiental, Universitat Politècnica de València, Camí de Vera, 14, València (Spain); Sanchez-Saez, F., E-mail: frasansa@etsii.upv.es [Departament d’Enginyeria Química i Nuclear, Universitat Politècnica de València, Camí de Vera, 14, València Spain (Spain); and others

    2016-02-15

    Highlights: • TRACE modelization for PKL and ROSA/LSTF installations. • Secondary-side depressurization as accident management action. • CET vs PCT relation. • Analysis of differences in the vessel models. - Abstract: Experimental facilities are scaled models of commercial nuclear power plants, and are of great importance to improve nuclear power plants safety. Thus, the results obtained in the experiments undertaken in such facilities are essential to develop and improve the models implemented in the thermal-hydraulic codes, which are used in safety analysis. The experiments and inter-comparisons of the simulated results are usually performed in the frame of international programmes in which different groups of several countries simulate the behaviour of the plant under the accidental conditions established, using different codes and models. The results obtained are compared and studied to improve the knowledge on codes performance and nuclear safety. Thus, the Nuclear Energy Agency (NEA), in the nuclear safety work area, auspices several programmes which involve experiments in different experimental facilities. Among the experiments proposed in NEA programmes, one on them consisted of performing a counterpart test between ROSA/LSTF and PKL facilities, with the main objective of determining the effectiveness of late accident management actions in a small break loss of coolant accident (SBLOCA). This study was proposed as a result of the conclusion obtained by the NEA Working Group on the Analysis and Management of Accidents, which analyzed different installations and observed differences in the measurements of core exit temperature (CET) and maximum peak cladding temperature (PCT). In particular, the transient consists of a small break loss of coolant accident (SBLOCA) in a hot leg with additional failure of safety systems but with accident management measures (AM), consisting of a fast secondary-side depressurization, activated by the CET. The paper

  7. Post-test analysis of the ROSA/LSTF and PKL counterpart test

    International Nuclear Information System (INIS)

    Carlos, S.; Querol, A.; Gallardo, S.; Sanchez-Saez, F.

    2016-01-01

    Highlights: • TRACE modelization for PKL and ROSA/LSTF installations. • Secondary-side depressurization as accident management action. • CET vs PCT relation. • Analysis of differences in the vessel models. - Abstract: Experimental facilities are scaled models of commercial nuclear power plants, and are of great importance to improve nuclear power plants safety. Thus, the results obtained in the experiments undertaken in such facilities are essential to develop and improve the models implemented in the thermal-hydraulic codes, which are used in safety analysis. The experiments and inter-comparisons of the simulated results are usually performed in the frame of international programmes in which different groups of several countries simulate the behaviour of the plant under the accidental conditions established, using different codes and models. The results obtained are compared and studied to improve the knowledge on codes performance and nuclear safety. Thus, the Nuclear Energy Agency (NEA), in the nuclear safety work area, auspices several programmes which involve experiments in different experimental facilities. Among the experiments proposed in NEA programmes, one on them consisted of performing a counterpart test between ROSA/LSTF and PKL facilities, with the main objective of determining the effectiveness of late accident management actions in a small break loss of coolant accident (SBLOCA). This study was proposed as a result of the conclusion obtained by the NEA Working Group on the Analysis and Management of Accidents, which analyzed different installations and observed differences in the measurements of core exit temperature (CET) and maximum peak cladding temperature (PCT). In particular, the transient consists of a small break loss of coolant accident (SBLOCA) in a hot leg with additional failure of safety systems but with accident management measures (AM), consisting of a fast secondary-side depressurization, activated by the CET. The paper

  8. THE SCUBA-2 COSMOLOGY LEGACY SURVEY: MULTIWAVELENGTH COUNTERPARTS TO 10{sup 3} SUBMILLIMETER GALAXIES IN THE UKIDSS-UDS FIELD

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Chian-Chou; Smail, Ian; Ma, Cheng-Jiun; Simpson, James M.; Swinbank, A. Mark [Centre for Extragalactic Astronomy, Department of Physics, Durham University, South Road, Durham DH1 3LE (United Kingdom); Ivison, Rob J.; Arumugam, Vinodiran; Mortlock, Alice; Dunlop, James S.; Michałowski, Michał J. [Institute for Astronomy, University of Edinburgh, Royal Observatory, Blackford Hill, Edinburgh EH9 3HJ (United Kingdom); Almaini, Omar; Conselice, Christopher J.; Hartley, Will G. [University of Nottingham, School of Physics and Astronomy, Nottingham, NG7 2RD (United Kingdom); Geach, James E. [Center for Astrophysics Research, Science and Technology Research Institute, University of Hertfordshire, Hatfield AL10 9AB (United Kingdom); Simpson, Chris [Astrophysics Research Institute, Liverpool John Moores University, Liverpool Science Park, 146 Brownlow Hill, Liverpool L3 5RF (United Kingdom); Aretxaga, Itziar [Instituto Nacional de Astrofísica, Óptica y Electrónica (INAOE), Luis Enrique Erro 1, Sta. Ma. Tonantzintla, Puebla (Mexico); Blain, Andrew [Physics and Astronomy, University of Leicester, Leicester, LE1 7RH (United Kingdom); Chapman, Scott C. [Department of Physics and Atmospheric Science, Dalhousie University, 6310 Coburg Road, Halifax, NS B3H 4R2 (Canada); Farrah, Duncan [Department of Physics, Virginia Tech, Blacksburg, VA 24061 (United States); Halpern, Mark [Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, BC V6T 1Z1 (Canada); and others

    2016-04-01

    We present multiwavelength identifications for the counterparts of 1088 submillimeter sources detected at 850 μm in the SCUBA-2 Cosmology Legacy Survey study of the UKIRT Infrared Deep Sky Survey-Ultra-Deep Survey (UDS) field. By utilizing an Atacama Large Millimeter Array (ALMA) pilot study on a subset of our bright SCUBA-2 sample as a training set, along with the deep optical–near-infrared (OIR) data available in this field, we develop a novel technique, Optical–IR Triple Color (OIRTC), using z − K, K − [3.6], [3.6] − [4.5] colors to select the candidate submillimeter galaxy (SMG) counterparts. By combining radio identification and the OIRTC technique, we find counterpart candidates for 80% of the Class = 1 ≥ 4σ SCUBA-2 sample, defined as those that are covered by both radio and OIR imaging and the base sample for our scientific analyses. Based on the ALMA training set, we expect the accuracy of these identifications to be 82% ± 20%, with a completeness of 69% ± 16%, essentially as accurate as the traditional p-value technique but with higher completeness. We find that the fraction of SCUBA-2 sources having candidate counterparts is lower for fainter 850 μm sources, and we argue that for follow-up observations sensitive to SMGs with S{sub 850} ≳ 1 mJy across the whole ALMA beam, the fraction with multiple counterparts is likely to be >40% for SCUBA-2 sources at S{sub 850} ≳ 4 mJy. We find that the photometric redshift distribution for the SMGs is well fit by a lognormal distribution, with a median redshift of z = 2.3 ± 0.1. After accounting for the sources without any radio and/or OIRTC counterpart, we estimate the median redshift to be z = 2.6 ± 0.1 for SMGs with S{sub 850} > 1 mJy. We also use this new large sample to study the clustering of SMGs and the far-infrared properties of the unidentified submillimeter sources by stacking their Herschel SPIRE far-infrared emission.

  9. Comparison of Physical Fitness Parameters with EUROFIT Test Battery of Male Adolescent Soccer Players and Sedentary Counterparts

    Directory of Open Access Journals (Sweden)

    Özgür ERİKOĞLU

    2015-09-01

    Full Text Available The aim of this study was to compare physical fitness parameters of male adolescent soccer players and sedentary counterparts. A total of 26 male adolescents participated in this study voluntarily: Active soccer players (n: 3, age x : 13,00 ± 0,00 and sedentary counterparts (n: 13, age x :12,92 ± 0,75. The EUROFIT test battery was used to determine physical fitness. The test battery includes body height and weight measurements, touching the discs, flamingo balan ce, throwing health ball, vertical jumping, sit and reach, sit - up for 30 s, 20 meter sprint run, and 20 meter shuttle run tests. Data were analyzed by Mann Whitney U test. Significance was defined as p.05. In conclusion, children who do sports are more successful on most of the fitness parameters than sedentary children.

  10. THE NATURE OF THE BRIGHT ULX X-2 IN NGC 3921: A CHANDRA POSITION AND HST CANDIDATE COUNTERPART

    Energy Technology Data Exchange (ETDEWEB)

    Jonker, P. G.; Heida, M.; Torres, M. A. P.; Ratti, E. M. [SRON, Netherlands Institute for Space Research, Sorbonnelaan 2, 3584 CA Utrecht (Netherlands); Miller-Jones, J. C. A. [International Centre for Radio Astronomy Research, Curtin University, GPO Box U1987, Perth, WA 6845 (Australia); Fabian, A. C.; Walton, D. J. [Institute of Astronomy, Madingley Road, Cambridge CB3 0HA (United Kingdom); Miniutti, G. [Centro de Astrobiologia (CSIC-INTA), Departamento de Astrofisica, ESA, P.O. Box 78, E-28691 Villanueva de la Canada, Madrid (Spain); Roberts, T. P., E-mail: p.jonker@sron.nl [Department of Physics, Durham University, South Road, Durham DH1 3LE (United Kingdom)

    2012-10-10

    We report on Chandra observations of the bright ultraluminous X-ray (ULX) source in NGC 3921. Previous XMM-Newton observations reported in the literature show the presence of a bright ULX at a 0.5-10 keV luminosity of 2 Multiplication-Sign 10{sup 40} erg s{sup -1}. Our Chandra observation finds the source at a lower luminosity of Almost-Equal-To 8 Multiplication-Sign 10{sup 39} erg s{sup -1}; furthermore, we provide a Chandra position of the ULX accurate to 0.''7 at 90% confidence. The X-ray variability makes it unlikely that the high luminosity is caused by several separate X-ray sources. In three epochs of archival Hubble Space Telescope observations, we find a candidate counterpart to the ULX. There is direct evidence for variability between the two epochs of WFPC2 F814W observations with the observation obtained in 2000 showing a brighter source. Furthermore, converting the 1994 F336W and 2000 F300W WFPC2 and the 2010 F336W WFC3 observations to the Johnson U-band filter assuming a spectral type of O7I, we find evidence for a brightening of the U-band light in 2000. Using the higher resolution WFC3 observations, we resolve the candidate counterpart into two sources of similar color. We discuss the nature of the ULX and the probable association with the optical counterpart(s). Finally, we investigate a potential new explanation for some (bright) ULXs as the decaying stages of flares caused by the tidal disruption of a star by a recoiled supermassive black hole. However, we find that there should be at most only one of such systems within z = 0.08.

  11. Achilles tendon injuries in elite athletes: lessons in pathophysiology from their equine counterparts.

    Science.gov (United States)

    Patterson-Kane, Janet C; Rich, Tina

    2014-01-01

    Superficial digital flexor tendon (SDFT) injury in equine athletes is one of the most well-accepted, scientifically supported companion animal models of human disease (i.e., exercise-induced Achilles tendon [AT] injury). The SDFT and AT are functionally and clinically equivalent (and important) energy-storing structures for which no equally appropriate rodent, rabbit, or other analogues exist. Access to equine tissues has facilitated significant advances in knowledge of tendon maturation and aging, determination of specific exercise effects (including early life), and definition of some of the earliest stages of subclinical pathology. Access to human surgical biopsies has provided complementary information on more advanced phases of disease. Importantly, equine SDFT injuries are only a model for acute ruptures in athletes, not the entire spectrum of human tendonopathy (including chronic tendon pain). In both, pathology begins with a potentially prolonged phase of accumulation of (subclinical) microdamage. Recent work has revealed remarkably similar genetic risk factors, including further evidence that tenocyte dysfunction plays an active role. Mice are convenient but not necessarily accurate models for multiple diseases, particularly at the cellular level. Mechanistic studies, including tendon cell responses to combinations of exercise-associated stresses, require a more thorough investigation of cross-species conservation of key stress pathway auditors. Molecular evidence has provided some context for the poor performance of mouse models; equines may provide better systems at this level. The use of horses may be additionally justifiable based on comparable species longevity, lifestyle factors, and selection pressure by similar infectious agents (e.g., herpesviruses) on general cell stress pathway evolution. © The Author 2014. Published by Oxford University Press on behalf of the Institute for Laboratory Animal Research. All rights reserved. For permissions

  12. Search for high confidence AGN candidates and its counterparts in the Fermi-LAT unassociated sample using machine learning

    Energy Technology Data Exchange (ETDEWEB)

    Einecke, Sabrina [Technical University Dortmund (Germany); Doert, Marlene [Ruhr-University Bochum (Germany)

    2016-07-01

    The third Fermi-LAT source catalog (3FGL) is the deepest all-sky survey in gamma-rays and comprises 3033 point sources. While for 2023 sources plausible associations have been found, 1010 remain unassociated. A search for active galactic nuclei (AGN) will help to reduce the number of unassociated sources, and will increase our knowledge of the population of gamma-ray emitting AGN. Several machine learning approaches applied to Fermi data have shown the capability of this method. The extension to multiwavelength data improves these studies, and at the same time offers the possibility to determine the most likely corresponding counterpart. As the 95% confidence region of the localization by the Fermi measurement is in the order of several arcminutes, generally multiple point sources at different wavelengths are located within this region and the association is ambiguous. To figure out the most likely counterpart, the associated sample is used to train machine learning classifiers as e.g. the random forest. Therefore, all possible combinations of the Fermi measurement and the measurements at a second wavelength are considered for a particular source. In this talk, the statistical model to obtain high confidence AGN counterpart candidates is described as well as the validation of the model to estimate the performance.

  13. Chronic pancreatitis.

    Science.gov (United States)

    Kleeff, Jorg; Whitcomb, David C; Shimosegawa, Tooru; Esposito, Irene; Lerch, Markus M; Gress, Thomas; Mayerle, Julia; Drewes, Asbjørn Mohr; Rebours, Vinciane; Akisik, Fatih; Muñoz, J Enrique Domínguez; Neoptolemos, John P

    2017-09-07

    Chronic pancreatitis is defined as a pathological fibro-inflammatory syndrome of the pancreas in individuals with genetic, environmental and/or other risk factors who develop persistent pathological responses to parenchymal injury or stress. Potential causes can include toxic factors (such as alcohol or smoking), metabolic abnormalities, idiopathic mechanisms, genetics, autoimmune responses and obstructive mechanisms. The pathophysiology of chronic pancreatitis is fairly complex and includes acinar cell injury, acinar stress responses, duct dysfunction, persistent or altered inflammation, and/or neuro-immune crosstalk, but these mechanisms are not completely understood. Chronic pancreatitis is characterized by ongoing inflammation of the pancreas that results in progressive loss of the endocrine and exocrine compartment owing to atrophy and/or replacement with fibrotic tissue. Functional consequences include recurrent or constant abdominal pain, diabetes mellitus (endocrine insufficiency) and maldigestion (exocrine insufficiency). Diagnosing early-stage chronic pancreatitis is challenging as changes are subtle, ill-defined and overlap those of other disorders. Later stages are characterized by variable fibrosis and calcification of the pancreatic parenchyma; dilatation, distortion and stricturing of the pancreatic ducts; pseudocysts; intrapancreatic bile duct stricturing; narrowing of the duodenum; and superior mesenteric, portal and/or splenic vein thrombosis. Treatment options comprise medical, radiological, endoscopic and surgical interventions, but evidence-based approaches are limited. This Primer highlights the major progress that has been made in understanding the pathophysiology, presentation, prevalence and management of chronic pancreatitis and its complications.

  14. QUEST FOR COSMOS SUBMILLIMETER GALAXY COUNTERPARTS USING CARMA AND VLA: IDENTIFYING THREE HIGH-REDSHIFT STARBURST GALAXIES

    International Nuclear Information System (INIS)

    Smolčić, V.; Navarrete, F.; Bertoldi, F.; Aravena, M.; Sheth, K.; Ilbert, O.; Yun, M. S.; Salvato, M.; Finoguenov, A.; McCracken, H. J.; Diener, C.; Aretxaga, I.; Hughes, D.; Wilson, G.; Riechers, D. A.; Capak, P.; Scoville, N. Z.; Karim, A.; Schinnerer, E.

    2012-01-01

    We report on interferometric observations at 1.3 mm at 2''-3'' resolution using the Combined Array for Research in Millimeter-wave Astronomy. We identify multi-wavelength counterparts of three submillimeter galaxies (SMGs; F 1m > 5.5 mJy) in the COSMOS field, initially detected with MAMBO and AzTEC bolometers at low, ∼10''-30'', resolution. All three sources—AzTEC/C1, Cosbo-3, and Cosbo-8—are identified to coincide with positions of 20 cm radio sources. Cosbo-3, however, is not associated with the most likely radio counterpart, closest to the MAMBO source position, but with that farther away from it. This illustrates the need for intermediate-resolution (∼2'') mm-observations to identify the correct counterparts of single-dish-detected SMGs. All of our three sources become prominent only at NIR wavelengths, and their mm-to-radio flux based redshifts suggest that they lie at redshifts z ∼> 2. As a proof of concept, we show that photometric redshifts can be well determined for SMGs, and we find photometric redshifts of 5.6 ± 1.2, 1.9 +0.9 –0.5 , and ∼4 for AzTEC/C1, Cosbo-3, and Cosbo-8, respectively. Using these we infer that these galaxies have radio-based star formation rates of ∼> 1000 M ☉ yr –1 and IR luminosities of ∼10 13 L ☉ consistent with properties of high-redshift SMGs. In summary, our sources reflect a variety of SMG properties in terms of redshift and clustering, consistent with the framework that SMGs are progenitors of z ∼ 2 and today's passive galaxies.

  15. Comparison of nutritional value of transgenic peanut expressing bar and rcg3 genes with non-transgenic counterparts

    International Nuclear Information System (INIS)

    Robab, U.E.; )

    2014-01-01

    The transgenic peanut plants expressing bar and rcg3 genes were subjected to assessment of any change in nutritional value of the crop at various locations. The protein and fat contents of transgenic lines were compared with the non-transgenic parent varieties. Protein content in the transgenic lines was higher as compared to that in non-transgenic counterparts and differences among locations for fat and protein content were significant. No differences among fatty acids were recorded for genes, events and locations. Irrespective of small differences, all the values were in range described for this crop and transgenic lines appeared to be substantially equivalent to non-transgenic parent varieties. (author)

  16. [Chronic diarrhea].

    Science.gov (United States)

    Stelzer, Teresa; Heuss, Ludwig Theodor

    2014-09-01

    Defined by lasting more than four weeks - is a common but often challenging clinical scenario. It is important to be aware that diarrhoea means different things to different patients. The evaluation of chronic diarrhoea depends on taking an excellent history and careful physical examination as well as planning investigations thoughtfully. Functional diarrhea ist the most common cause of chronic diarrhea in the developed countries and motility disorders are more common than inflammatory, osmotic or secretory causes. In some cases categorizing patients by their stool characteristics can be helpful in directing further evaluation.

  17. An Enhanced Method for Scheduling Observations of Large Sky Error Regions for Finding Optical Counterparts to Transients

    Energy Technology Data Exchange (ETDEWEB)

    Rana, Javed; Singhal, Akshat; Gadre, Bhooshan; Bhalerao, Varun; Bose, Sukanta, E-mail: javed@iucaa.in [Inter-University Centre for Astronomy and Astrophysics, Post Bag 4, Ganeshkhind, Pune 411 007 (India)

    2017-04-01

    The discovery and subsequent study of optical counterparts to transient sources is crucial for their complete astrophysical understanding. Various gamma-ray burst (GRB) detectors, and more notably the ground-based gravitational wave detectors, typically have large uncertainties in the sky positions of detected sources. Searching these large sky regions spanning hundreds of square degrees is a formidable challenge for most ground-based optical telescopes, which can usually image less than tens of square degrees of the sky in a single night. We present algorithms for better scheduling of such follow-up observations in order to maximize the probability of imaging the optical counterpart, based on the all-sky probability distribution of the source position. We incorporate realistic observing constraints such as the diurnal cycle, telescope pointing limitations, available observing time, and the rising/setting of the target at the observatory’s location. We use simulations to demonstrate that our proposed algorithms outperform the default greedy observing schedule used by many observatories. Our algorithms are applicable for follow-up of other transient sources with large positional uncertainties, such as Fermi -detected GRBs, and can easily be adapted for scheduling radio or space-based X-ray follow-up.

  18. Chronic myelogenous leukemia (CML)

    Science.gov (United States)

    CML; Chronic myeloid leukemia; Chronic granulocytic leukemia; Leukemia - chronic granulocytic ... nuclear disaster. It takes many years to develop leukemia from radiation exposure. Most people treated for cancer ...

  19. Chronic Meningococcaemia

    African Journals Online (AJOL)

    clinical features, complications, laboratory findings and treatment of this condition are discussed. The resemblance, both clinically and histologically, to allergic vasculitis is stressed. S. Air. Med. J., 48, 2154 (1974). Chronic meningococcaemia is an uncommon condition today, but was well recognised in the early decades of.

  20. Chronic gastritis.

    Science.gov (United States)

    Sipponen, Pentti; Maaroos, Heidi-Ingrid

    2015-06-01

    Prevalence of chronic gastritis has markedly declined in developed populations during the past decades. However, chronic gastritis is still one of the most common serious pandemic infections with such severe killing sequelae as peptic ulcer or gastric cancer. Globally, on average, even more than half of people may have a chronic gastritis at present. Helicobacter pylori infection in childhood is the main cause of chronic gastritis, which microbial origin is the key for the understanding of the bizarre epidemiology and course of the disease. A life-long and aggressive inflammation in gastritis results in destruction (atrophic gastritis) of stomach mucosa with time (years and decades). The progressive worsening of atrophic gastritis results subsequently in dysfunctions of stomach mucosa. Atrophic gastritis will finally end up in a permanently acid-free stomach in the most extreme cases. Severe atrophic gastritis and acid-free stomach are the highest independent risk conditions for gastric cancer known so far. In addition to the risks of malignancy and peptic ulcer, acid-free stomach and severe forms of atrophic gastritis may associate with failures in absorption of essential vitamins, like vitamin B12, micronutrients (like iron, calcium, magnesium and zinc), diet and medicines.

  1. Chronic Pancreatitis

    International Nuclear Information System (INIS)

    Betancur, Jorge

    2002-01-01

    It is presented a case of a man with alcoholic chronic pancreatitis, whose marked dilatation of the ducts reasoned the issue. The severe untreatable pain was the surgery indication, which was practiced without complications either during or after the surgery. By the way, a shallow revision of the literature is made, by mentioning classification, physiopatholoy, clinical square, medical, surgical and endoscopic treatment

  2. Identifying resilient and non-resilient middle-adolescents in a ...

    African Journals Online (AJOL)

    The aim in this study was to develop a way of identifying resilient and non- resilient middle adolescents in a formerly black-only urban residential (township) school, in order to ultimately support the development of learners' resilience under stressful circumstances. A Resilience Scale was developed to screen for resilient ...

  3. Chronic Myelogenous Leukemia

    Science.gov (United States)

    Chronic myelogenous leukemia Overview Chronic myelogenous leukemia (CML) is an uncommon type of cancer of the blood cells. The term "chronic" in chronic myelogenous leukemia indicates that this cancer ...

  4. Chronic motor tic disorder

    Science.gov (United States)

    Chronic vocal tic disorder; Tic - chronic motor tic disorder ... Chronic motor tic disorder is more common than Tourette syndrome . Chronic tics may be forms of Tourette syndrome. Tics usually start ...

  5. Chronic thyroiditis (Hashimoto disease)

    Science.gov (United States)

    Hashimoto thyroiditis; Chronic lymphocytic thyroiditis; Autoimmune thyroiditis; Chronic autoimmune thyroiditis; Lymphadenoid goiter - Hashimoto; Hypothyroidism - Hashimoto; Type 2 polyglandular autoimmune ...

  6. Differential production of proteolytic enzymes by normal human fibroblasts and their counterparts transformed by treatment with 60Co gamma rays

    International Nuclear Information System (INIS)

    Nishitani, Koji; Namba, Masayoshi; Ohkubo, Shigeki; Kimoto, Tetsuo

    1985-01-01

    Production of proteolytic enzymes by human fibroblasts in the process of transformation was investigated. The cells used were normal human fibroblasts (KSM-6) and their in vitro counterparts transformed by treatment with 60 Co gamma rays (KMST-6). Cells seeded by treatment with EDTA were cultured in a serum free medium. Proteolytic enzymes in the culture medium of cells were assayed using a synthetic substrate, N-α-(p-tosyl)-L-arginine ( 3 H) methyl ester hydrochloride. The transformed cells (KMST-6) produced a larger amount of enzymes than normal cells (KMS-6). The enzyme production in both cell lines was high in the exponential growth stage and then decreased as the cells reached confluency. The proteolytic enzymes produced by these cells were trypsin- and thrombin-like enzymes. Cell growth of KMST-6 or KMS-6 was not inhibited by the addition of protease inhibitors to the culture medium. (author)

  7. Distribution of apparent activation energy counterparts during thermo - And thermo-oxidative degradation of Aronia melanocarpa (black chokeberry).

    Science.gov (United States)

    Janković, Bojan; Marinović-Cincović, Milena; Janković, Marija

    2017-09-01

    Kinetics of degradation for Aronia melanocarpa fresh fruits in argon and air atmospheres were investigated. The investigation was based on probability distributions of apparent activation energy of counterparts (ε a ). Isoconversional analysis results indicated that the degradation process in an inert atmosphere was governed by decomposition reactions of esterified compounds. Also, based on same kinetics approach, it was assumed that in an air atmosphere, the primary compound in degradation pathways could be anthocyanins, which undergo rapid chemical reactions. A new model of reactivity demonstrated that, under inert atmospheres, expectation values for ε a occured at levels of statistical probability. These values corresponded to decomposition processes in which polyphenolic compounds might be involved. ε a values obeyed laws of binomial distribution. It was established that, for thermo-oxidative degradation, Poisson distribution represented a very successful approximation for ε a values where there was additional mechanistic complexity and the binomial distribution was no longer valid. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Comparative study of He bubble formation in nanostructured reduced activation steel and its coarsen-grained counterpart

    Science.gov (United States)

    Liu, W. B.; Zhang, J. H.; Ji, Y. Z.; Xia, L. D.; Liu, H. P.; Yun, D.; He, C. H.; Zhang, C.; Yang, Z. G.

    2018-03-01

    High temperature (550 °C) He ions irradiation was performed on nanostructured (NS) and coarsen-grained (CG) reduced activation steel to investigate the effects of GBs/interfaces on the formation of bubbles during irradiation. Experimental results showed that He bubbles were preferentially trapped at dislocations and/or grain boundaries (GBs) for both of the samples. Void denuded zones (VDZs) were observed in the CG samples, while VDZs near GBs were unobvious in NS sample. However, both the average bubble size and the bubble density in peak damage region of the CG sample were significantly larger than that observed in the NS sample, which indicated that GBs play an important role during the irradiation, and the NS steel had better irradiation resistance than its CG counterpart.

  9. RODOS - The domestic counterpart

    International Nuclear Information System (INIS)

    Vamanu, Dan V.

    1999-01-01

    One term of reference for validly teaming up with Project RODOS (Real-Time-On-Line Decision Support System for Nuclear Emergencies in Europe) is to institutionally - contribute research initiatives geared towards emulating the RODOS functions on novel conceptual pathways, expand system's coverage of issues that are relevant in a nuclear crisis management and bring in a domestic perspective on how the system may best perform in each and every national - i.e. legal, managerial, logistic and cultural environment. On this line, one reviews the approach taken in the IFIN-HH RODOS Group to address the challenge, as well a number of representative outputs. These include: i) A phase-one, pre-RODOS, period (1990 - 1994), involving topical field orientation, feasibility demonstrations and expertise acquisition by hands-on training in environmental radiology modeling and DSS code development, the resulting products - codes in the 'APUD' and 'ACA-IFA' family, including custom versions developed by appointment of the IAEA Safety Section and AECL-Research, Ontario, Canada - being favourably reviewed by the NEA/OECD Data Bank; ii) A phase-two, upgrading and consolidation period (1994 -1996), assisted by the IAEA fellowship system and the US Government via the Nuclear Regulatory Commission in Washington, D.C, having on record an effective participation in the development of the US NRC, EPA, and DOE's 'FRMAC Assessment Manual - The Federal manual for Assessing Environmental Data during a Radiological Emergency', and the 'RTM-95 International Technical Response Manual', and the research initiative of developing a software support for the manuals' implementation - the codes 'ROBOT' (Rule-Oriented Basic Operational Tool); iii) A phase-three period (1996 - ), evolving within the RODOS framework and featuring, inter alia: (a) the application of the ROBOT concept in the development of a standalone software platform, code-named NOTEPAD for DSS support in field operations, nuclear accident drills, expert service provision on issues such as siting and health and environmental impact assessment, mainly targeting the accident source near-field; (b) a likewise experiment in the summary assessment of the far-field consequences of an atmospheric release ('QuickFIX'); (c) a research initiative in modeling the dispersion in complex topography terrains, using linearized equations of the mesoscale meteorology and heuristic concepts; (d) the development, by appointment of the Swiss Federal Institute of Technology ETH-Zurich and under the joint guidance of Institut de protection et de surete nucleaire CEA-IPSN and Kernforschungszentrum Karlsruhe, of the technical specifications and working - prototypes of the 'CONTAINMENT' module in the software package 'STEPS' (Source Term Estimation based on Plant Status). (author)

  10. Biological characteristics and clinical outcome of triple negative primary breast cancer in older women - comparison with their younger counterparts.

    Directory of Open Access Journals (Sweden)

    Binafsha M Syed

    Full Text Available Triple negative (ER, PgR and HER2 negative breast cancers (TNBCs are often considered as a poor prognostic phenotype. There is dearth of evidence showing the prevalence and biological behaviour of TNBCs in older women. This study aimed to analyse their biological characteristics in comparison with a well characterised younger series from a single centre with long term clinical follow-up. Over 37 years (1973-2010, 1,758 older (≥70 years women with early operable (<5 cm primary breast cancer were managed in a dedicated clinic and have complete clinical information available. Of these 813 patients underwent primary surgery and 575 had good quality tumour samples available for tissue microarray analysis using indirect immunohistochemistry. A total of 127 patients (22.1% had TNBCs and full biological analysis of 15 biomarkers was performed. The results were compared with those of their younger (<70 years counterparts 342 (18.9% from a previously characterised, consecutive series of primary breast cancer treated in the same unit (1986-1998. The 127 older patients with TNBCs showed lower rates of Ki67 and CK 7/8 positivity and high rates of bcl2 and CK18 positivity when compared with their younger counterparts (p<0.05. There was no significant difference in the long term clinical outcome between the two age groups, despite the fact that 47% of the younger patients had adjuvant chemotherapy, while none in the older cohort received such treatment. EGFR, axillary stage and pathological size showed prognostic significance in older women with TNBCs on univariate analysis. Despite not having received adjuvant chemotherapy, the older series had clinical outcome similar to the younger patients almost half of whom had chemotherapy. This appears to be related to other biomarkers (in addition to ER/PgR/HER2 eg Ki67, bcl2 and cytokeratins which have different expression patterns influencing prognosis.

  11. The Discovery of the Electromagnetic Counterpart of GW170817: Kilonova AT 2017gfo/DLT17ck

    International Nuclear Information System (INIS)

    Valenti, Stefano; Yang, Sheng; Tartaglia, Leonardo; Sand, David J.; Cappellaro, Enrico; Corsi, Alessandra; Jha, Saurabh W.; Reichart, Daniel E.; Haislip, Joshua; Kouprianov, Vladimir

    2017-01-01

    During the second observing run of the Laser Interferometer Gravitational-wave Observatory (LIGO) and Virgo Interferometer, a gravitational-wave signal consistent with a binary neutron star coalescence was detected on 2017 August 17th (GW170817), quickly followed by a coincident short gamma-ray burst trigger detected by the Fermi satellite. The Distance Less Than 40 (DLT40) Mpc supernova search performed pointed follow-up observations of a sample of galaxies regularly monitored by the survey that fell within the combined LIGO+Virgo localization region and the larger Fermi gamma-ray burst error box. Here we report the discovery of a new optical transient (DLT17ck, also known as SSS17a; it has also been registered as AT 2017gfo) spatially and temporally coincident with GW170817. The photometric and spectroscopic evolution of DLT17ck is unique, with an absolute peak magnitude of M _r = −15.8 ± 0.1 and an r -band decline rate of 1.1 mag day"−"1. This fast evolution is generically consistent with kilonova models, which have been predicted as the optical counterpart to binary neutron star coalescences. Analysis of archival DLT40 data does not show any sign of transient activity at the location of DLT17ck down to r ∼ 19 mag in the time period between 8 months and 21 days prior to GW170817. This discovery represents the beginning of a new era for multi-messenger astronomy, opening a new path by which to study and understand binary neutron star coalescences, short gamma-ray bursts, and their optical counterparts.

  12. Bimodal Long-lasting Components in Short Gamma-Ray Bursts: Promising Electromagnetic Counterparts to Neutron Star Binary Mergers

    Energy Technology Data Exchange (ETDEWEB)

    Kisaka, Shota; Sakamoto, Takanori [Department of Physics and Mathematics, Aoyama Gakuin University, Sagamihara, Kanagawa, 252-5258 (Japan); Ioka, Kunihito, E-mail: kisaka@phys.aoyama.ac.jp, E-mail: tsakamoto@phys.aoyama.ac.jp, E-mail: kunihito.ioka@yukawa.kyoto-u.ac.jp [Center for Gravitational Physics, Yukawa Institute for Theoretical Physics, Kyoto University, Kyoto 606-8502 (Japan)

    2017-09-10

    Long-lasting emission of short gamma-ray bursts (GRBs) is crucial to reveal the physical origin of the central engine as well as to detect electromagnetic (EM) counterparts to gravitational waves (GWs) from neutron star binary mergers. We investigate 65 X-ray light curves of short GRBs, which is six times more than previous studies, by combining both Swift /BAT and XRT data. The light curves are found to consist of two distinct components at >5 σ with bimodal distributions of luminosity and duration, i.e., extended (with a timescale of ≲10{sup 3} s) and plateau emission (with a timescale of ≳10{sup 3} s), which are likely the central engine activities, but not afterglows. The extended emission has an isotropic energy comparable to the prompt emission, while the plateau emission has ∼0.01–1 times this energy. Half (50%) of our sample has both components, while the other half is consistent with having both components. This leads us to conjecture that almost all short GRBs have both the extended and plateau emission. The long-lasting emission can be explained by the jets from black holes with fallback ejecta, and could power macronovae (or kilonovae) like GRB 130603B and GRB 160821B. Based on the observed properties, we quantify the detectability of EM counterparts to GWs, including the plateau emission scattered to the off-axis angle, with CALET /HXM, INTEGRAL /SPI-ACS, Fermi /GBM, MAXI /GSC, Swift /BAT, XRT, the future ISS-Lobster /WFI, Einstein Probe /WXT, and eROSITA .

  13. The Discovery of the Electromagnetic Counterpart of GW170817: Kilonova AT 2017gfo/DLT17ck

    Energy Technology Data Exchange (ETDEWEB)

    Valenti, Stefano; Yang, Sheng; Tartaglia, Leonardo [Department of Physics, University of California, 1 Shields Avenue, Davis, CA 95616-5270 (United States); Sand, David J. [Department of Astronomy/Steward Observatory, 933 North Cherry Avenue, Room N204, Tucson, AZ 85721-0065 (United States); Cappellaro, Enrico [INAF Osservatorio Astronomico di Padova, Vicolo dell’Osservatorio 5, I-35122 Padova (Italy); Corsi, Alessandra [Physics and Astronomy Department, Texas Tech University, Lubbock, TX 79409 (United States); Jha, Saurabh W. [Department of Physics and Astronomy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 (United States); Reichart, Daniel E.; Haislip, Joshua; Kouprianov, Vladimir [Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (United States)

    2017-10-20

    During the second observing run of the Laser Interferometer Gravitational-wave Observatory (LIGO) and Virgo Interferometer, a gravitational-wave signal consistent with a binary neutron star coalescence was detected on 2017 August 17th (GW170817), quickly followed by a coincident short gamma-ray burst trigger detected by the Fermi satellite. The Distance Less Than 40 (DLT40) Mpc supernova search performed pointed follow-up observations of a sample of galaxies regularly monitored by the survey that fell within the combined LIGO+Virgo localization region and the larger Fermi gamma-ray burst error box. Here we report the discovery of a new optical transient (DLT17ck, also known as SSS17a; it has also been registered as AT 2017gfo) spatially and temporally coincident with GW170817. The photometric and spectroscopic evolution of DLT17ck is unique, with an absolute peak magnitude of M {sub r} = −15.8 ± 0.1 and an r -band decline rate of 1.1 mag day{sup −1}. This fast evolution is generically consistent with kilonova models, which have been predicted as the optical counterpart to binary neutron star coalescences. Analysis of archival DLT40 data does not show any sign of transient activity at the location of DLT17ck down to r ∼ 19 mag in the time period between 8 months and 21 days prior to GW170817. This discovery represents the beginning of a new era for multi-messenger astronomy, opening a new path by which to study and understand binary neutron star coalescences, short gamma-ray bursts, and their optical counterparts.

  14. Nuclear counterparts of the cytoplasmic mitochondrial 12S rRNA gene: a problem of ancient DNA and molecular phylogenies.

    Science.gov (United States)

    van der Kuyl, A C; Kuiken, C L; Dekker, J T; Perizonius, W R; Goudsmit, J

    1995-06-01

    Monkey mummy bones and teeth originating from the North Saqqara Baboon Galleries (Egypt), soft tissue from a mummified baboon in a museum collection, and nineteenth/twentieth-century skin fragments from mangabeys were used for DNA extraction and PCR amplification of part of the mitochondrial 12S rRNA gene. Sequences aligning with the 12S rRNA gene were recovered but were only distantly related to contemporary monkey mitochondrial 12S rRNA sequences. However, many of these sequences were identical or closely related to human nuclear DNA sequences resembling mitochondrial 12S rRNA (isolated from a cell line depleted in mitochondria) and therefore have to be considered contamination. Subsequently in a separate study we were able to recover genuine mitochondrial 12S rRNA sequences from many extant species of nonhuman Old World primates and sequences closely resembling the human nuclear integrations. Analysis of all sequences by the neighbor-joining (NJ) method indicated that mitochondrial DNA sequences and their nuclear counterparts can be divided into two distinct clusters. One cluster contained all temporary cytoplasmic mitochondrial DNA sequences and approximately half of the monkey nuclear mitochondriallike sequences. A second cluster contained most human nuclear sequences and the other half of monkey nuclear sequences with a separate branch leading to human and gorilla mitochondrial and nuclear sequences. Sequences recovered from ancient materials were equally divided between the two clusters. These results constitute a warning for when working with ancient DNA or performing phylogenetic analysis using mitochondrial DNA as a target sequence: Nuclear counterparts of mitochondrial genes may lead to faulty interpretation of results.

  15. A Therapeutic Approach for Treating Chronic Illness and Disability among College Students

    Science.gov (United States)

    Haemmelmann, Katie L.; McClain, Mary-Catherine

    2013-01-01

    Research in chronic illness and disability (CID) in college students has demonstrated that students with disabilities encounter more difficulties psychosocially than their nondisabled counterparts. Subsequently, these difficulties impact the ability of these students to successfully adapt. Using the illness intrusiveness model in combination with…

  16. Chronic Pancreatitis

    International Nuclear Information System (INIS)

    Vavrecka, A.; Bilicky, J.

    2011-01-01

    Chronic pancreatitis is an ongoing inflammatory process that may over time lead to mal digestion, malabsorption and diabetic syndrome. Identification of risk (etiological) factors based on classifications TIGAR-O or later M-ANNHEIM. These factors (environmental and / or genetic) leads to failure of the stability of the digestive and lysosomal enzymes in the acinar cells, resulting in premature activation of digestive enzymes in the pancreas, and repeated nekroinflamation and fibrosis. The incidence has of the upward trend. Clinically the disease manifests itself in most cases with pain and possibly with nonspecific dyspeptic troubles. Decisive role in the diagnosis playing imaging methods, trans abdominal ultrasonography, computed tomography, magnetic resonance imaging, magnetic cholangiopancretography and foremost endoscopic ultrasonography, which has the highest sensitivity and specificity. Endoscopic retrograde cholangiopancreatography is currently regarded as a method for therapy, not for diagnosis. Less importance is now attached to a functional test. Symptomatic treatment is usually conservative. Abstinence is necessary, easily digestible, but calorie-rich diet with reduced fat. Most patients needed treatment with analgesics. In case of insufficient effect of analgesics is necessary to consider endoscopic therapy or surgery. If the external secretory insufficiency is present are served pancreatic extracts. Diabetic syndrome requires insulin delivery. Generally, chronic pancreatitis is a disease treatable but incurable. Proportion of patients are also dying of pancreatic cancer. (author)

  17. NEW OPTICAL/ULTRAVIOLET COUNTERPARTS AND THE SPECTRAL ENERGY DISTRIBUTIONS OF NEARBY, THERMALLY EMITTING, ISOLATED NEUTRON STARS

    International Nuclear Information System (INIS)

    Kaplan, D. L.; Kamble, A.; Van Kerkwijk, M. H.; Ho, W. C. G.

    2011-01-01

    We present Hubble Space Telescope optical and ultraviolet photometry for five nearby, thermally emitting neutron stars. With these measurements, all seven such objects have confirmed optical and ultraviolet counterparts. Combining our data with archival space-based photometry, we present spectral energy distributions for all sources and measure the 'optical excess': the factor by which the measured photometry exceeds that extrapolated from X-ray spectra. We find that the majority have optical and ultraviolet fluxes that are inconsistent with that expected from thermal (Rayleigh-Jeans) emission, exhibiting more flux at longer wavelengths. We also find that most objects have optical excesses between 5 and 12, but that one object (RX J2143.0+0654) exceeds the X-ray extrapolation by a factor of more than 50 at 5000 A, and that this is robust to uncertainties in the X-ray spectra and absorption. We consider explanations for this ranging from atmospheric effects, magnetospheric emission, and resonant scattering, but find that none is satisfactory.

  18. TOWARD UNDERSTANDING THE B[e] PHENOMENON. III. PROPERTIES OF THE OPTICAL COUNTERPART OF IRAS 00470+6429

    International Nuclear Information System (INIS)

    Miroshnichenko, A. S.; Chentsov, E. L.; Klochkova, V. G.; Zharikov, S. V.; Grankin, K. N.; Kusakin, A. V.; Gandet, T. L.; Klingenberg, G.; Kildahl, S.; Rudy, R. J.; Lynch, D. K.; Venturini, C. C.; Mazuk, S.; Puetter, R. C.; Perry, R. B.; Carciofi, A. C.; Bjorkman, K. S.; Gray, R. O.; Bernabei, S.; Polcaro, V. F.

    2009-01-01

    FS CMa type stars are a group of Galactic objects with the B[e] phenomenon. They exhibit strong emission-line spectra and infrared excesses, which are most likely due to recently formed circumstellar dust. The group content and identification criteria were described in the first two papers of the series. In this paper we report our spectroscopic and photometric observations of the optical counterpart of IRAS 00470+6429 obtained in 2003-2008. The optical spectrum is dominated by emission lines, most of which have P Cyg type profiles. We detected significant brightness variations, which may include a regular component, and variable spectral line profiles in both shape and position. The presence of a weak Li I 6708 A line in the spectrum suggests that the object is most likely a binary system with a B2-B3 spectral-type primary companion of a luminosity log L/L sun = 3.9 ± 0.3 and a late-type secondary companion. We estimate a distance toward the object to be 2.0 ± 0.3 kpc from the Sun.

  19. Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA.

    Directory of Open Access Journals (Sweden)

    Niek Wit

    Full Text Available Monoubiquitylation of the homotrimeric DNA sliding clamp PCNA at lysine residue 164 (PCNA(K164 is a highly conserved, DNA damage-inducible process that is mediated by the E2/E3 complex Rad6/Rad18. This ubiquitylation event recruits translesion synthesis (TLS polymerases capable of replicating across damaged DNA templates. Besides PCNA, the Rad6/Rad18 complex was recently shown in yeast to ubiquitylate also 9-1-1, a heterotrimeric DNA sliding clamp composed of Rad9, Rad1, and Hus1 in a DNA damage-inducible manner. Based on the highly similar crystal structures of PCNA and 9-1-1, K185 of Rad1 (Rad1(K185 was identified as the only topological equivalent of PCNA(K164. To investigate a potential role of posttranslational modifications of Rad1(K185 in DNA damage management, we here generated a mouse model with a conditional deletable Rad1(K185R allele. The Rad1(K185 residue was found to be dispensable for Chk1 activation, DNA damage survival, and class switch recombination of immunoglobulin genes as well as recruitment of TLS polymerases during somatic hypermutation of immunoglobulin genes. Our data indicate that Rad1(K185 is not a functional counterpart of PCNA(K164.

  20. Thermodynamic Stability of Ice II and Its Hydrogen-Disordered Counterpart: Role of Zero-Point Energy.

    Science.gov (United States)

    Nakamura, Tatsuya; Matsumoto, Masakazu; Yagasaki, Takuma; Tanaka, Hideki

    2016-03-03

    We investigate why no hydrogen-disordered form of ice II has been found in nature despite the fact that most of hydrogen-ordered ices have hydrogen-disordered counterparts. The thermodynamic stability of a set of hydrogen-ordered ice II variants relative to ice II is evaluated theoretically. It is found that ice II is more stable than the disordered variants so generated as to satisfy the simple ice rule due to the lower zero-point energy as well as the pair interaction energy. The residual entropy of the disordered ice II phase gradually compensates the unfavorable free energy with increasing temperature. The crossover, however, occurs at a high temperature well above the melting point of ice III. Consequently, the hydrogen-disordered phase does not exist in nature. The thermodynamic stability of partially hydrogen-disordered ices is also scrutinized by examining the free-energy components of several variants obtained by systematic inversion of OH directions in ice II. The potential energy of one variant is lower than that of the ice II structure, but its Gibbs free energy is slightly higher than that of ice II due to the zero-point energy. The slight difference in the thermodynamic stability leaves the possibility of the partial hydrogen-disorder in real ice II.

  1. A Dark Energy Camera Search for an Optical Counterpart to the First Advanced LIGO Gravitational Wave Event GW150914

    Science.gov (United States)

    Soares-Santos, M.; Kessler, R.; Burger, E.; Annis, J.; Brout, D.; Buckley-Geer, E.; Chen, H.; Cowperthwaite, P. S.; Diehl, H.T.; Doctor, Z.; hide

    2016-01-01

    We report the results of a deep search for an optical counterpart to the gravitational wave (GW) event GW150914, the first trigger from the Advanced LIGO GW detectors. We used the Dark Energy Camera (DECam) to image a 102 deg(exp 2) area, corresponding to 38% of the initial trigger high-probability sky region and to 11% of the revised high-probability region. We observed in the i and z bands at 4-5, 7, and 24 days after the trigger. The median 5(sigma) point-source limiting magnitudes of our search images are i = 22.5 and z = 21.8 mag. We processed the images through a difference-imaging pipeline using templates from pre-existing Dark Energy Survey data and publicly available DECam data. Due to missing template observations and other losses, our effective search area subtends 40 deg(exp 2), corresponding to a 12% total probability in the initial map and 3% in the final map. In this area, we search for objects that decline significantly between days 4-5 and day 7, and are undetectable by day 24, finding none to typical magnitude limits of i = 21.5, 21.1, 20.1 for object colors (i-z)= 1, 0, -1, respectively. Our search demonstrates the feasibility of a dedicated search program with DECam and bodes well for future research in this emerging field.

  2. CYGNUS X-3: ITS LITTLE FRIEND’S COUNTERPART, THE DISTANCE TO CYGNUS X-3, AND OUTFLOWS/JETS

    Energy Technology Data Exchange (ETDEWEB)

    McCollough, M. L.; Dunham, M. M. [Smithsonian Astrophysical Observatory, 60 Garden Street, Cambridge, MA 02138 (United States); Corrales, L., E-mail: mmccollough@cfa.harvard.edu [Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States)

    2016-10-20

    Chandra observations have revealed a feature within 16″ of Cygnus X-3 that varied in phase with Cygnus X-3. This feature was shown to be a Bok globule that is along the line of sight to Cygnus X-3. We report on observations made with the Submillimeter Array to search for molecular emission from this globule, also known as Cygnus X-3's “Little Friend.” We have found a counterpart in both {sup 12}CO (2-1) and {sup 13}CO (2-1) emission. From the velocity shift of the molecular lines we are able to find two probable distances based on the Bayesian model of Milky Way kinematics of Reid et al. For the LF velocity of −47.5 km s{sup −1}, we find distances of 6.1 ± 0.6 kpc (62% probability) and 7.8 ± 0.6 kpc (38% probability). This yields distances to Cyg X-3 of 7.4 ± 1.1 kpc and 10.2 ± 1.2 kpc, respectively. Based on the probabilities entailed, we take 7.4 ± 1.1 kpc as the preferred distance to Cyg X-3. We also report the discovery of bipolar molecular outflow, suggesting that there is active star formation occurring within the Little Friend.

  3. UNVEILING THE NATURE OF THE UNIDENTIFIED GAMMA-RAY SOURCES. III. GAMMA-RAY BLAZAR-LIKE COUNTERPARTS AT LOW RADIO FREQUENCIES

    Energy Technology Data Exchange (ETDEWEB)

    Massaro, F.; Funk, S. [SLAC National Laboratory and Kavli Institute for Particle Astrophysics and Cosmology, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); D' Abrusco, R.; Paggi, A. [Harvard-Smithsonian Astrophysical Observatory, 60 Garden Street, Cambridge, MA 02138 (United States); Giroletti, M. [INAF Istituto di Radioastronomia, via Gobetti 101, I-40129 Bologna (Italy); Masetti, N. [INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica di Bologna, via Gobetti 101, I-40129 Bologna (Italy); Tosti, G. [Dipartimento di Fisica, Universita degli Studi di Perugia, I-06123 Perugia (Italy); Nori, M. [Department of Physics and Astronomy, University of Bologna, viale Berti Pichat 6/2, I-40127 Bologna (Italy)

    2013-07-01

    About one-third of the {gamma}-ray sources listed in the second Fermi Large Area Telescope catalog (2FGL) have no firmly established counterpart at lower energies and so are classified as unidentified gamma-ray sources (UGSs). Here, we propose a new approach to find candidate counterparts for the UGSs based on the 325 MHz radio survey performed with the Westerbork Synthesis Radio Telescope in the northern hemisphere. First, we investigate the low-frequency radio properties of blazars, the largest known population of {gamma}-ray sources; then we search for sources with similar radio properties combining the information derived from the Westerbork Northern Sky Survey (WENSS) with those of the NRAO Very Large Array Sky Survey. We present a list of candidate counterparts for 32 UGSs with at least one counterpart in the WENSS. We also performed an extensive research in the literature to look for infrared and optical counterparts of the {gamma}-ray blazar candidates selected using the low-frequency radio observations to confirm their nature. On the basis of our multifrequency research, we identify 23 new {gamma}-ray blazar candidates out of the 32 UGSs investigated. Comparison with previous results on the UGSs is also presented. Finally, we speculate on the advantages of using low-frequency radio observations to associate UGSs and to search for {gamma}-ray pulsar candidates.

  4. Older Korean adults have lower physical function despite longer exercise times compared to their Japanese counterparts: A Japan-Korea comparative study.

    Science.gov (United States)

    Jung, Songee; Okubo, Yoshiro; Osuka, Yosuke; Seino, Satoshi; Park, Joonsung; Nho, Hosung; Tanaka, Kiyoji

    2018-04-01

    We aimed to compare the level of physical function (PF) and habitual exercise between older Japanese and Korean adults. A comparative study was carried out on 1069 community-dwelling older Japanese and Korean adults (mean age 73.9 ± 5.2 years). The participants were asked to complete a self-reported questionnaire regarding habitual exercise and covariates. PF age, a composite measure of PF, was derived from the 12 items, using principal component analysis. PF age and habitual exercise were compared between the Japanese and Korean adults, using analysis of covariance (ancova) and multivariable logistic regression analysis adjusted for all covariates using propensity scores. ancova showed that PF age in older Japanese adults was significantly younger than in their Korean counterparts. Older Japanese adults exercised significantly less frequently than their Korean counterparts. Furthermore, older Japanese adults practiced significantly less walking, mountain climbing and bicycling, but more calisthenics, resistance training, ball games and dances than their Korean counterparts. We found that older Korean adults had lower PF (3.7 years older in PF age) than their Japanese counterparts. Although the overall frequency and amount of habitual exercise in older Korean adults were higher than those in their Japanese counterparts, particular types of exercise might have contributed to the higher PF levels among older Japanese adults. Thus, older Korean adults might need to engage more in habitual exercises that are specifically effective in maintaining PF. Geriatr Gerontol Int 2018; 18: 576-583. © 2017 Japan Geriatrics Society.

  5. Atypical Chronic Myelogenous Leukemia

    Science.gov (United States)

    ... myeloproliferative neoplasms, leukemia , and other conditions . Chronic Myelomonocytic Leukemia Key Points Chronic myelomonocytic leukemia is a disease ... chance of recovery) and treatment options. Chronic myelomonocytic leukemia is a disease in which too many myelocytes ...

  6. Chronic lymphocytic leukemia (CLL)

    Science.gov (United States)

    ... is used for painful and enlarged lymph nodes. Blood transfusions or platelet transfusions may be required if blood ... unexplained fatigue, bruising, excessive sweating, or weight loss. Alternative ... Leukemia - chronic lymphocytic (CLL); Blood cancer - chronic lymphocytic leukemia; Bone marrow cancer - chronic ...

  7. Chronic Pancreatitis in Children

    Science.gov (United States)

    ... E-News Sign-Up Home Patient Information Children/Pediatric Chronic Pancreatitis in Children Chronic Pancreatitis in Children What symptoms would my child have? Frequent or chronic abdominal pain is the most common symptom of pancreatitis. The ...

  8. Searching for gamma-ray counterparts to gravitational waves from merging binary neutron stars with the Cherenkov Telescope Array

    Science.gov (United States)

    Patricelli, B.; Stamerra, A.; Razzano, M.; Pian, E.; Cella, G.

    2018-05-01

    The merger of binary neutron star (BNS) systems are predicted to be progenitors of short gamma-ray bursts (GRBs); the definitive probe of this association came with the recent detection of gravitational waves (GWs) from a BNS merger by Advanced LIGO and Advanced Virgo (GW170817), in coincidence with the short GRB 170817A observed by Fermi-GBM and INTEGRAL. Short GRBs are also expected to emit very-high energy (VHE, > 10S0 GeV) photons and VHE electromagnetic (EM) upper limits have been set with observations performed by ground-based gamma-ray detectors and during the intense EM follow-up campaign associated with GW170817/GRB 170817A. In the next years, the searches for VHE EM counterparts will become more effective thanks to the Cherenkov Telescope Array (CTA): this instrument will be fundamental for the EM follow-up of transient GW events at VHE, owing to its unprecedented sensitivity, rapid response (few tens of seconds) and capability to monitor large sky areas via survey-mode operation. We present a comprehensive study on the prospects for joint GW and VHE EM observations of merging BNSs with Advanced LIGO, Advanced Virgo and CTA, based on detailed simulations of the multi-messenger emission and detection. We propose a new observational strategy optimized on the prior assumptions about the EM emission. The method can be further generalized to include other electromagnetic emission models. According to this study CTA will cover most of the region of the GW skymap for the intermediate and most energetic on-axis GRBs associated to the GW event. We estimate the expected joint GW and VHE EM detection rates and we found this rate goes from 0.08 up to 0.5 events per year for the most energetic EM sources.

  9. Paying for convenience: comparing the cost of takeaway meals with their healthier home-cooked counterparts in New Zealand.

    Science.gov (United States)

    Mackay, Sally; Vandevijvere, Stefanie; Xie, Pei; Lee, Amanda; Swinburn, Boyd

    2017-09-01

    Convenience and cost impact on people's meal decisions. Takeaway and pre-prepared foods save preparation time but may contribute to poorer-quality diets. Analysing the impact of time on relative cost differences between meals of varying convenience contributes to understanding the barrier of time to selecting healthy meals. Six popular New Zealand takeaway meals were identified from two large national surveys and compared with similar, but healthier, home-made and home-assembled meals that met nutrition targets consistent with New Zealand Eating and Activity Guidelines. The cost of each complete meal, cost per kilogram, and confidence intervals of the cost of each meal type were calculated. The time-inclusive cost was calculated by adding waiting or preparation time cost at the minimum wage. A large urban area in New Zealand. For five of six popular meals, the mean cost of the home-made and home-assembled meals was cheaper than the takeaway meals. When the cost of time was added, all home-assembled meal options were the cheapest and half of the home-made meals were at least as expensive as the takeaway meals. The home-prepared meals were designed to provide less saturated fat and Na and more vegetables than their takeaway counterparts; however, the home-assembled meals provided more Na than the home-made meals. Healthier home-made and home-assembled meals were, except one, cheaper options than takeaways. When the cost of time was added, either the home-made or the takeaway meal was the most expensive. This research questions whether takeaways are better value than home-prepared meals.

  10. Associating Fast Radio Bursts with Extragalactic Radio Sources: General Methodology and a Search for a Counterpart to FRB 170107

    Science.gov (United States)

    Eftekhari, T.; Berger, E.; Williams, P. K. G.; Blanchard, P. K.

    2018-06-01

    The discovery of a repeating fast radio burst (FRB) has led to the first precise localization, an association with a dwarf galaxy, and the identification of a coincident persistent radio source. However, further localizations are required to determine the nature of FRBs, the sources powering them, and the possibility of multiple populations. Here we investigate the use of associated persistent radio sources to establish FRB counterparts, taking into account the localization area and the source flux density. Due to the lower areal number density of radio sources compared to faint optical sources, robust associations can be achieved for less precise localizations as compared to direct optical host galaxy associations. For generally larger localizations that preclude robust associations, the number of candidate hosts can be reduced based on the ratio of radio-to-optical brightness. We find that confident associations with sources having a flux density of ∼0.01–1 mJy, comparable to the luminosity of the persistent source associated with FRB 121102 over the redshift range z ≈ 0.1–1, require FRB localizations of ≲20″. We demonstrate that even in the absence of a robust association, constraints can be placed on the luminosity of an associated radio source as a function of localization and dispersion measure (DM). For DM ≈1000 pc cm‑3, an upper limit comparable to the luminosity of the FRB 121102 persistent source can be placed if the localization is ≲10″. We apply our analysis to the case of the ASKAP FRB 170107, using optical and radio observations of the localization region. We identify two candidate hosts based on a radio-to-optical brightness ratio of ≳100. We find that if one of these is indeed associated with FRB 170107, the resulting radio luminosity (1029‑ 4 × 1030 erg s‑1 Hz‑1, as constrained from the DM value) is comparable to the luminosity of the FRB 121102 persistent source.

  11. Newly synthesized MgAl2Ge2: A first-principles comparison with its silicide and carbide counterparts

    Science.gov (United States)

    Tanveer Karim, A. M. M.; Hadi, M. A.; Alam, M. A.; Parvin, F.; Naqib, S. H.; Islam, A. K. M. A.

    2018-06-01

    Using plane-wave pseudopotential density functional theory (DFT), the first-principle calculations are performed to investigate the structural aspects, mechanical behaviors and electronic features of the newly synthesized CaAl2Si2-prototype intermetallic compound, MgAl2Ge2 for the first time and the results are compared with those calculated for its silicide and carbide counterparts MgAl2Si2 and MgAl2C2. The calculated lattice constants agree fairly well with their corresponding experimental values. The estimated elastic tensors satisfy the mechanical stability conditions for MgAl2Ge2 along with MgAl2Si2 and MgAl2C2. The level of elastic anisotropy increases following the sequence of X-elements Ge → Si → C. MgAl2Ge2 and MgAl2Si2 are expected to be ductile and damage tolerant, while MgAl2C2 is a brittle one. MgAl2Ge2 and MgAl2Si2 should exhibit better thermal shock resistance and low thermal conductivity and accordingly these can be used as thermal barrier coating (TBC) materials. The Debye temperature of MgAl2Ge2 is lowest among three intermetallic compounds. MgAl2Ge2 and MgAl2Si2 should exhibit metallic conductivity; while the dual characters of weak-metals and semiconductors are expected for MgAl2C2. The values of theoretical Vickers hardness for MgAl2Ge2, MgAl2Si2, and MgAl2C2 are 3.3, 2.7, and 7.7 GPa, respectively, indicating that these three intermetallics are soft and easily machinable.

  12. Transcriptomal profiling of bovine ovarian granulosa and theca interna cells in primary culture in comparison with their in vivo counterparts.

    Directory of Open Access Journals (Sweden)

    Nicholas Hatzirodos

    Full Text Available In vitro culture of ovarian granulosa cells and theca cells has been very important for our understanding of their function and regulation. One of the most eagerly sought attributes of cell culture is the use of chemically-defined conditions. However, even under such in vitro conditions cell behaviour could differ from the in vivo situation because of differences in oxygen tension, nutrients, adhesion matrix and other factors. To examine this further we compared the transcriptomes of both granulosa cells and cells from the theca interna that were cultured in what are arguably the best in vitro conditions for maintaining the 'follicular' phenotypes of both tissue types, as displayed by their respective freshly-isolated counterparts. The array data analysed are from recently published data and use the same sizes of bovine follicles (small antral 3-6 mm and the same Affymetrix arrays. We conducted analysis using Partek, Ingenuity Pathway Analysis and GOEAST. Principal Component Analysis (PCA and hierarchical clustering clearly separated the in vivo from the in vitro groups for both cells types and transcriptomes were more homogeneous upon culture. In both cell cultures behaviours associated with cell adhesion, migration and interaction with matrix or substrate were more abundant. However, the pathways involved generally differed between the two cell types. With the thecal cultures a gene expression signature of an immune response was more abundant, probably by leukocytes amongst the cells cultured from the theca interna. These results indicate differences between in vivo and in vitro that should be considered when interpreting in vitro data.

  13. Acetylcholinesterase immobilization and characterization, and comparison of the activity of the porous silicon-immobilized enzyme with its free counterpart.

    Science.gov (United States)

    Saleem, Muhammad; Rafiq, Muhammad; Seo, Sung-Yum; Lee, Ki Hwan

    2016-02-02

    A successful prescription is presented for acetylcholinesterase physically adsorbed on to a mesoporous silicon surface, with a promising hydrolytic response towards acetylthiocholine iodide. The catalytic behaviour of the immobilized enzyme was assessed by spectrophotometric bioassay using neostigmine methyl sulfate as a standard acetycholinesterase inhibitor. The surface modification was studied through field emission SEM, Fourier transform IR spectroscopy, energy-dispersive X-ray spectroscopy, cathode luminescence and X-ray photoelectron spectroscopy analysis, photoluminescence measurement and spectrophotometric bioassay. The porous silicon-immobilized enzyme not only yielded greater enzyme stability, but also significantly improved the native photoluminescence at room temperature of the bare porous silicon architecture. The results indicated the promising catalytic behaviour of immobilized enzyme compared with that of its free counterpart, with a greater stability, and that it aided reusability and easy separation from the reaction mixture. The porous silicon-immobilized enzyme was found to retain 50% of its activity, promising thermal stability up to 90°C, reusability for up to three cycles, pH stability over a broad pH of 4-9 and a shelf-life of 44 days, with an optimal hydrolytic response towards acetylthiocholine iodide at variable drug concentrations. On the basis of these findings, it was believed that the porous silicon-immobilized enzyme could be exploited as a reusable biocatalyst and for screening of acetylcholinesterase inhibitors from crude plant extracts and synthesized organic compounds. Moreover, the immobilized enzyme could offer a great deal as a viable biocatalyst in bioprocessing for the chemical and pharmaceutical industries, and bioremediation to enhance productivity and robustness. © 2016 Authors.

  14. Chronic subdural hematoma

    Science.gov (United States)

    Subdural hemorrhage - chronic; Subdural hematoma - chronic; Subdural hygroma ... A subdural hematoma develops when bridging veins tear and leak blood. These are the tiny veins that run between the ...

  15. Chronic Diseases Overview

    Science.gov (United States)

    ... Plan Templates All Chronic Surveillance Systems Communications Center Social Media Press Room Press Release Archives Multimedia Communication Campaigns Publications Chronic Disease Overview 2016–2017 At A ...

  16. Chronic urticaria

    Directory of Open Access Journals (Sweden)

    Sandeep Sachdeva

    2011-01-01

    Full Text Available Chronic urticaria (CU is a disturbing allergic condition of the skin. Although frequently benign, it may sometimes be a red flag sign of a serious internal disease. A multitude of etiologies have been implicated in the causation of CU, including physical, infective, vasculitic, psychological and idiopathic. An autoimmune basis of most of the ′idiopathic′ forms is now hypothesized. Histamine released from mast cells is the major effector in pathogenesis and it is clinically characterized by wheals that have a tendency to recur. Laboratory investigations aimed at a specific etiology are not always conclusive, though may be suggestive of an underlying condition. A clinical search for associated systemic disease is strongly advocated under appropriate circumstances. The mainstay of treatment remains H1 antihistaminics. These may be combined with complementary pharmacopeia in the form of H2 blockers, doxepin, nifedipine and leukotriene inhibitors. More radical therapy in the form of immunoglobulins, plasmapheresis and cyclophosphamide may be required for recalcitrant cases. Autologous transfusion and alternative remedies like acupuncture have prospects for future. A stepwise management results in favorable outcomes. An update on CU based on our experience with patients at a tertiary care centre is presented.

  17. Overweight and obesity among Ghanaian residents in the Netherlands: How do they weigh against their urban and rural counterparts in Ghana?

    NARCIS (Netherlands)

    Agyemang, C.; Owusu-Dabo, E.; Jonge, A. de; Martins, D.; Ogedegbe, G.; Stronks, K.

    2009-01-01

    Objective: To investigate differences in overweight and obesity between first-generation Dutch-Ghanaian migrants in The Netherlands and their rural and urban counterparts in Ghana. Design: Cross-sectional study. Subjects: A total of 1471 Ghanaians (rural Ghanaians, n 532; urban Ghanaians, n 787;

  18. Near Infrared JHKs observations of the transient MAXI J1820+070 / ASASSN-18ey: Erratum on 2MASS counterpart designation

    Science.gov (United States)

    Mandal, A. K.; Singh, A.; Stalin, C. S.; Chandra, S.; Gandhi, P.

    2018-03-01

    In ATel #11458, the correct 2MASS counterpart associated with MAXI J1820+070/ASASSN-18ey should have been stated as 2MASS J18202194+0711073. We apologise for any misunderstanding, and thank G. Stringfellow and M. Tanaka for bringing this to our attention. The photometric analyses and discussion in ATel #11458 remain unchanged.

  19. Comparison of Scores on the WAIS and Its Puerto Rican Counterpart, Escala de Inteligencia Wechsler para Adultos, in an Institutionalized Latin American Psychiatric Population.

    Science.gov (United States)

    Davis, Todd McLin; Rodriguez, Vene L.

    1979-01-01

    Compared vocabulary and block design subtests of the Wechsler Adult Intelligence Scale (WAIS) and its Puerto Rican counterpart, the Escala de Inteligencia Wechsler para Adultos (EIWA), in hospitalized Latins and Trans-Caribbean Blacks. EIWA scores were significantly higher than WAIS scores. Equivalence of EIWA and WAIS estimates is questioned.…

  20. ON Bipolar Cells in Macaque Retina: Type-Specific Synaptic Connectivity with Special Reference to OFF Counterparts

    Science.gov (United States)

    Tsukamoto, Yoshihiko; Omi, Naoko

    2016-01-01

    To date, 12 macaque bipolar cell types have been described. This list includes all morphology types first outlined by Polyak (1941) using the Golgi method in the primate retina and subsequently identified by other researchers using electron microscopy (EM) combined with the Golgi method, serial section transmission EM (SSTEM), and immunohistochemical imaging. We used SSTEM for the rod-dense perifoveal area of macaque retina, reconfirmed ON (cone) bipolar cells to be classified as invaginating midget bipolar (IMB), diffuse bipolar (DB)4, DB5, DB6, giant bipolar (GB), and blue bipolar (BB) types, and clarified their type-specific connectivity. DB4 cells made reciprocal synapses with a kind of ON-OFF lateral amacrine cell, similar to OFF DB2 cells. GB cells contacted rods and cones, similar to OFF DB3b cells. Retinal circuits formed by GB and DB3b cells are thought to substantiate the psychophysical finding of fast rod signals in mesopic vision. DB6 cell output synapses were directed to ON midget ganglion (MG) cells at 70% of ribbon contacts, similar to OFF DB1 cells that directed 60% of ribbon contacts to OFF MG cells. IMB cells contacted medium- or long-wavelength sensitive (M/L-) cones but not short-wavelength sensitive (S-) cones, while BB cells contacted S-cones but not M/L-cones. However, IMB and BB dendrites had similar morphological architectures, and a BB cell contacting a single S-cone resembled an IMB cell. Thus, both IMB and BB may be the ON bipolar counterparts of the OFF flat midget bipolar (FMB) type, likewise DB4 of DB2, DB5 of DB3a, DB6 of DB1, and GB of DB3b OFF bipolar type. The ON DB plus GB, and OFF DB cells predominantly contacted M/L-cones and their outputs were directed mainly to parasol ganglion (PG) cells but also moderately to MG cells. BB cells directed S-cone-driven outputs almost exclusively to small bistratified ganglion (SBG) cells. Some FMB cells predominantly contacted S-cones and their outputs were directed to OFF MG cells. Thus, two

  1. Comparative neuropharmacology of N-(2-methoxybenzyl)-2,5-dimethoxyphenethylamine (NBOMe) hallucinogens and their 2C counterparts in male rats.

    Science.gov (United States)

    Elmore, Joshua S; Decker, Ann M; Sulima, Agnieszka; Rice, Kenner C; Partilla, John S; Blough, Bruce E; Baumann, Michael H

    2018-03-01

    2,5-Dimethoxyphenethylamines (2C compounds) are 5-HT 2A/2C receptor agonists that induce hallucinogenic effects. N-methoxybenzylation of 2C compounds markedly increases their affinity for 5-HT 2A receptors, and two such analogs, 2-(4-chloro-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25C-NBOMe) and 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25I-NBOMe), have emerged in recreational drug markets. Here, we investigated the neuropharmacology of 25C-NBOMe and 25I-NBOMe in rats, as compared to their 2C analogs and the prototypical 5-HT 2A/2C agonist 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine (DOI). Compounds were tested in vitro using 5-HT 2A receptor binding and calcium mobilization assays. For in vivo experiments, 25C-NBOMe (0.01-0.3 mg/kg), 25I-NBOMe (0.01-0.3 mg/kg), 2-(4-chloro-2,5-dimethoxyphenyl)ethanamine (2C-C) (0.1-3.0 mg/kg), 2-(4-iodo-2,5-dimethoxyphenyl)ethanamine (2C-I) (0.1-3.0 mg/kg) and DOI (0.03-1.0 mg/kg) were administered subcutaneously (sc) to male rats, and 5-HT 2A -mediated behaviors were assessed. NBOMes displayed higher affinity for 5-HT 2A receptors than their 2C counterparts but were substantially weaker in functional assays. 25C-NBOMe and 25I-NBOMe were much more potent at inducing wet dog shakes (WDS) and back muscle contractions (BMC) when compared to 2C-C and 2C-I. Pretreatment with the selective 5-HT 2A antagonist (R)-(2,3-dimethoxyphenyl){1-[2-(4-fluorophenyl)ethyl]-4-piperidinyl}methanol (M100907) reversed behaviors produced by all agonists. Interestingly, binding affinities at the 5-HT 2A receptor were significantly correlated with potencies to induce BMC but not WDS. Our findings show that NBOMes are highly potent 5-HT 2A agonists in rats, similar to effects in mice, and consistent with the reported hallucinogenic effects in human users. Copyright © 2018. Published by Elsevier Ltd.

  2. Finding counterparts for all-sky X-ray surveys with NWAY: a Bayesian algorithm for cross-matching multiple catalogues

    Science.gov (United States)

    Salvato, M.; Buchner, J.; Budavári, T.; Dwelly, T.; Merloni, A.; Brusa, M.; Rau, A.; Fotopoulou, S.; Nandra, K.

    2018-02-01

    We release the AllWISE counterparts and Gaia matches to 106 573 and 17 665 X-ray sources detected in the ROSAT 2RXS and XMMSL2 surveys with |b| > 15°. These are the brightest X-ray sources in the sky, but their position uncertainties and the sparse multi-wavelength coverage until now rendered the identification of their counterparts a demanding task with uncertain results. New all-sky multi-wavelength surveys of sufficient depth, like AllWISE and Gaia, and a new Bayesian statistics based algorithm, NWAY, allow us, for the first time, to provide reliable counterpart associations. NWAY extends previous distance and sky density based association methods and, using one or more priors (e.g. colours, magnitudes), weights the probability that sources from two or more catalogues are simultaneously associated on the basis of their observable characteristics. Here, counterparts have been determined using a Wide-field Infrared Survey Explorer (WISE) colour-magnitude prior. A reference sample of 4524 XMM/Chandra and Swift X-ray sources demonstrates a reliability of ∼94.7 per cent (2RXS) and 97.4 per cent (XMMSL2). Combining our results with Chandra-COSMOS data, we propose a new separation between stars and AGN in the X-ray/WISE flux-magnitude plane, valid over six orders of magnitude. We also release the NWAY code and its user manual. NWAY was extensively tested with XMM-COSMOS data. Using two different sets of priors, we find an agreement of 96 per cent and 99 per cent with published Likelihood Ratio methods. Our results were achieved faster and without any follow-up visual inspection. With the advent of deep and wide area surveys in X-rays (e.g. SRG/eROSITA, Athena/WFI) and radio (ASKAP/EMU, LOFAR, APERTIF, etc.) NWAY will provide a powerful and reliable counterpart identification tool.

  3. Supporting Self-management of Chronic Pain

    Science.gov (United States)

    2018-04-04

    Chronic Pain Syndrome; Chronic Pain; Chronic Pain Due to Injury; Chronic Pain Due to Trauma; Chronic Pain Due to Malignancy (Finding); Chronic Pain Post-Procedural; Chronic Pain Hip; Chronic Pain, Widespread

  4. [Chronic otitis mediaChronic Otitis Media].

    Science.gov (United States)

    Kohles, N; Schulz, T; Eßer, D

    2015-11-01

    There are 2 different kinds of chronic otitis media: Otitis media chronica mesotympanalis and otitis media chronica epitympanalis (cholesteatoma). The incidence of chronic otitis media as reported in literature differs in a wide range. The incidence rates vary between 0.45 and 46%. Both, otitis media chronica mesotympanalis and cholesteatoma, lead to eardrum perforation due to lengthy and recurring inflammations. Furthermore, chronic otitis media is characterized by frequently recurring otorrhea and conductive hearing loss. Georg Thieme Verlag KG Stuttgart · New York.

  5. Brucella-Salmonella lipopolysaccharide chimeras are less permeable to hydrophobic probes and more sensitive to cationic peptides and EDTA than are their native Brucella sp. counterparts.

    OpenAIRE

    Freer, E; Moreno, E; Moriyón, I; Pizarro-Cerdá, J; Weintraub, A; Gorvel, J P

    1996-01-01

    A rough (R) Brucella abortus 45/20 mutant was more sensitive to the bactericidal activity of polymyxin B and lactoferricin B than was its smooth (S) counterpart but considerably more resistant than Salmonella montevideo. The outer membrane (OM) and isolated lipopolysaccharide (LPS) of S. montevideo showed a higher affinity for these cationic peptides than did the corresponding B. abortus OM and LPS. We took advantage of the moderate sensitivity of R B. abortus to cationic peptides to construc...

  6. Chronic mucus hypersecretion

    DEFF Research Database (Denmark)

    Ulrik, Charlotte Suppli; von Linstow, Marie-Louise; Nepper-Christensen, Steen

    2005-01-01

    To investigate if chronic mucus hypersecretion (CMH) can be used as a marker of asthma in young adults.......To investigate if chronic mucus hypersecretion (CMH) can be used as a marker of asthma in young adults....

  7. Chronic tophaceous gout

    Directory of Open Access Journals (Sweden)

    Thappa D

    1993-01-01

    Full Text Available A rare case of chronic tophaceous gout, in a 27-year-old female on diuretics for chronic congestive cardiac failure with characteristic histopathological and radiological changes is reported.

  8. Chronic Kidney Diseases

    Science.gov (United States)

    ... Safe Videos for Educators Search English Español Chronic Kidney Diseases KidsHealth / For Kids / Chronic Kidney Diseases What's ... re talking about your kidneys. What Are the Kidneys? Your kidneys are tucked under your lower ribs ...

  9. Chronic Recurrent Multifocal Osteomyelitis

    African Journals Online (AJOL)

    Administrator

    OBJECTIVE: To present a case and review the literature on chronic ... Successful treatment is difficult to achieve, though some ... named the syndrome “subacute and chronic ... An assessment of acute ... scans can cause a significant radiation.

  10. Heredity of chronic bronchitis

    DEFF Research Database (Denmark)

    Meteran, Howraman; Backer, Vibeke; Kyvik, Kirsten Ohm

    2014-01-01

    BACKGROUND: Smoking is a major risk factor for lung diseases and lower respiratory symptoms, but since not all smokers develop chronic bronchitis and since chronic bronchitis is also diagnosed in never-smokers, it has been suggested that some individuals are more susceptible to develop chronic br...

  11. Ultrasound appearance of chronic mammary duct ectasia

    Energy Technology Data Exchange (ETDEWEB)

    Duchesne, N. [Ottawa Hospital, Dept. of Radiology, Ottawa, Ontario (Canada)]. E-mail: nathalie_duchesne_22@yahoo.ca; Skolnik, S. [Univ. of Toronto, Dept. of Family Medicine, Toronto, Ontario (Canada); Bilmer, S. [Ottawa Hospital, Dept. of Radiology, Ottawa, Ontario (Canada)

    2005-12-15

    Mammary duct ectasia (MDE), also called periductal mastitis, mammary dysplasia, or plasma cell mastitis, is a benign condition of the mammary gland first described by Haagensen in 1951. The etiology of MDE is unknown and its pathogenesis still controversial; the periductal inflammation could be either the cause or the result of dilated damaged ducts. The process is usually bilateral and asymptomatic, with only a small percentage of patients presenting with symptoms that may include long course of tumour formation, usually subareolar breast lumps, nipple discharge, nipple retraction, mastalgia, and mammary abscess or fistulas. Mammographic presentation of MDE is well known; its features include periductal calcification, benign intraductal calcification, and retroareolar duct dilatation. The periductal calcification results from dystrophic calcification and forms calcified rings or very dense, oval, elongated calcifications, each with a central lucency representing the dilated duct. Intraductal calcifications of duct ectasia represent inspissated intraductal material and are typically of uniform high density, often needle-like, and occasionally branching. Occasionally, there are no mammographic findings, and the diagnosis must rely on sonographic features. Appearance of MDE on ultrasonography (US) depends on the stage of the disease and the contents of the dilated ducts. The acute presentation has been demonstrated in the literature more often than has its chronic counterpart. In the former, duct content can vary from anechoic to isoechoic with surrounding fatty tissue. In chronic MDE, episodes of inflammation are longer. This tends to result in secretions that have a more solid, cheesy texture, partly due to cholesterol crystals, foam cells, and inflammatory cells. For both types of MDE, the appearance can mimic high-grade ductal carcinoma in situ (DCIS) on US. In this essay, 2 chronic MDE cases are presented and their US appearance discussed. Our goal is to explore

  12. Ultrasound appearance of chronic mammary duct ectasia

    International Nuclear Information System (INIS)

    Duchesne, N.; Skolnik, S.; Bilmer, S.

    2005-01-01

    Mammary duct ectasia (MDE), also called periductal mastitis, mammary dysplasia, or plasma cell mastitis, is a benign condition of the mammary gland first described by Haagensen in 1951. The etiology of MDE is unknown and its pathogenesis still controversial; the periductal inflammation could be either the cause or the result of dilated damaged ducts. The process is usually bilateral and asymptomatic, with only a small percentage of patients presenting with symptoms that may include long course of tumour formation, usually subareolar breast lumps, nipple discharge, nipple retraction, mastalgia, and mammary abscess or fistulas. Mammographic presentation of MDE is well known; its features include periductal calcification, benign intraductal calcification, and retroareolar duct dilatation. The periductal calcification results from dystrophic calcification and forms calcified rings or very dense, oval, elongated calcifications, each with a central lucency representing the dilated duct. Intraductal calcifications of duct ectasia represent inspissated intraductal material and are typically of uniform high density, often needle-like, and occasionally branching. Occasionally, there are no mammographic findings, and the diagnosis must rely on sonographic features. Appearance of MDE on ultrasonography (US) depends on the stage of the disease and the contents of the dilated ducts. The acute presentation has been demonstrated in the literature more often than has its chronic counterpart. In the former, duct content can vary from anechoic to isoechoic with surrounding fatty tissue. In chronic MDE, episodes of inflammation are longer. This tends to result in secretions that have a more solid, cheesy texture, partly due to cholesterol crystals, foam cells, and inflammatory cells. For both types of MDE, the appearance can mimic high-grade ductal carcinoma in situ (DCIS) on US. In this essay, 2 chronic MDE cases are presented and their US appearance discussed. Our goal is to explore

  13. Physical Activity Level of Korean Adults with Chronic Diseases: The Korean National Health and Nutritional Examination Survey, 2010-2012.

    Science.gov (United States)

    Jin, Ho-Seong; An, Ah-Reum; Choi, Ho-Chun; Lee, Sang-Hyun; Shin, Dong-Heon; Oh, Seung-Min; Seo, Young-Gyun; Cho, Be-Long

    2015-11-01

    Proper physical activities are known to be helpful in the prevention and management of chronic diseases. However, the physical activity level of patients with chronic diseases is low. Therefore, this study aimed to investigate the physical activity compliance of patients with hypertension, diabetes, and dyslipidemia in Korea. This study analyzed the 2010-2012 Fifth Korean National Health and Nutrition Examination Survey data. We included 13,873 individuals in the analysis. The level of physical activity compliance was measured by performing multivariate logistic regression analyses. In the univariate analysis, the subjects with hypertension or diabetes tended to comply with the physical activity guidelines less faithfully than their healthy counterparts. The proportion of subjects with hypertension who were insufficiently physically active was 65.4% among the men and 75.8% among the women. For diabetes, the proportions were 66.7% and 76.8%, respectively. No significant difference was found between the subjects with dyslipidemia and their healthy counterparts. In the multivariate logistic regression analysis, no significant difference in physical activity compliance was observed between the subjects with hypertension, diabetes, or dyslipidemia and their healthy counterparts for both sexes. The patients with hypertension or diabetes tended to have lower physical activity prevlaence than their healthy counterparts. However, for dyslipidemia, no significant difference was found between the two groups. Given the significance of physical activities in the management of chronic diseases, the physical activities of these patients need to be improved.

  14. A Counterpart Test of the VISTA-ITL SB-SIS-07 using the FESTA (SMART-ITL) Facility for the SMART Design

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hyunsik; Bae, Hwang; Ryu, Seonguk; Yi, Sungjae [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Ko, Yungjoo [System Engineering and Technology Co., Ltd., Daejeon (Korea, Republic of)

    2014-05-15

    The SMART design is characterized by the introduction of simplified and improved safety systems such as PRHRS, and its integral arrangement of the reactor vessel assembly. The integrated reactor vessel assembly consists of a reactor core, eight steam generators, four reactor coolant pumps, and a steam pressurizer, and it has four trains of a secondary system and passive residual heat removal system. The SMART design was fully assessed through various thermal-hydraulic validation tests during the licensing review process. Among them, a small-scale integral effect test facility of VISTA-ITL was used to investigate various thermal-hydraulic phenomena during design basis accident scenarios such as SBLOCA and CLOF, and the acquired data were used to validate the related thermal-hydraulic models of the safety analysis codes such as MARS-KS and TASS/SMR-S. The VISTA-ITL facility is a reduced height, 1/1310-volume scaled test facility with a single train of a secondary system and PRHRS. Recently, a large-scale integral effect test facility of FESTA was constructed in KAERI and a set of integral effect tests for design basis accident scenarios is also being performed. The role of FESTA could be extended to examine and verify the normal, abnormal, and emergency operating procedures required during the construction phases of SMART. It could be called as a counterpart test when similar experiments are performed in differently scaled facilities. It is clear that transient scenarios measured in the experimental rigs cannot be directly extrapolated to the plant conditions. Nevertheless one of the objectives of counter-part tests is to evaluate the influence of the geometric dimensions of the loops upon the evolution of a given accident. In this paper the counterpart test results with both the VISTA-ITL and FESTA facilities will be compared on a SBLOCA scenario of the SIS line break for the SMART design. As counter-part tests for an SBLOCA for the SMART design, two integral effect

  15. Life Disparity before, during and after Stagnation of Danish Female Life Expectancy. a Cause of Death Analysis and a Comparison with Their Scandinavian Counterparts

    DEFF Research Database (Denmark)

    Aburto, José Manuel; Wensink, Maarten Jan; Lindahl-Jacobsen, Rune

    that as Norway increasingly came to resemble Sweden in terms of high life expectancy, it also came to resemble Sweden in terms of low lifespan inequality. Next, we aim to make similar decompositions for Sweden and Norway, and aim to disentangle cohort effects from the question: what can Denmark do now...... cancers and non-infectious respiratory diseases, offsetting continuous improvement in cardiovascular mortality. Before and after stagnation, life expectancy increased as disparity decreased, as the cardiovascular revolution unfolded. Comparing Denmark and its Scandinavian counterparts, we find...

  16. Comparison of visual working memory in deaf and hearing-impaired students with normal counterparts: A research in people without sign language

    Directory of Open Access Journals (Sweden)

    Farideh Tangestani Zadeh

    2015-02-01

    Full Text Available Background and Aim: The hearing defects in deaf and hearing-impaired students also affect their cognitive skills such as memory in addition to communication skills. Hence, the aim of this study was to compare visual working memory in deaf and hearing-impaired students with that in normal counterparts.Method: In the present study, which was a causal-comparative study using the André Rey test, 30 deaf and 30 hearing-impaired students were compared with 30 students in a normal group, and they were matched based on gender, intelligence, educational grade, and socioeconomic status.Findings: Findings show that there is significant difference between the three groups’ subjects (p0.05.Conclusion: Function of deaf or hard-of-hearing students in the visual working memory task was weaker in comparison with the normal counterparts, while the two deaf and hard-of-hearing groups have similar functions. With a better identification and understanding of the factors that affect the development of this cognitive ability, we can offer new methods of teaching and reduce many of the disadvantages of this group of people in the different fields of cognitive science.

  17. Differential structural status of the RNA counterpart of an undecamer quasi-palindromic DNA sequence present in LCR of human β-globin gene cluster.

    Science.gov (United States)

    Kaushik, Mahima; Kukreti, Shrikant

    2015-01-01

    Our previous work on structural polymorphism shown at a single nucleotide polymorphism (SNP) (A → G) site located on HS4 region of locus control region (LCR) of β-globin gene has established a hairpin → duplex equilibrium corresponding to A → B like DNA transition (Kaushik M, Kukreti, R., Grover, D., Brahmachari, S.K. and Kukreti S. Nucleic Acids Res. 2003; Kaushik M, Kukreti S. Nucleic Acids Res. 2006). The G-allele of A → G SNP has been shown to be significantly associated with the occurrence of β-thalassemia. Considering the significance of this 11-nt long quasi-palindromic sequence [5'-TGGGG(G/A)CCCCA; HP(G/A)11] of β-globin gene LCR, we further explored the differential behavior of the same DNA sequence with its RNA counterpart, using various biophysical and biochemical techniques. In contrast to its DNA counterpart exhibiting a A → B structural transition and an equilibrium between duplex and hairpin forms, the studied RNA oligonucleotide sequence [5'-UGGGG(G/A)CCCCA; RHP(G/A)11] existed only in duplex form (A-conformation) and did not form hairpin. The single residue difference from A to G led to the unusual thermal stability of the RNA structure formed by the studied sequence. Since, naturally occurring mutations and various SNP sites may stabilize or destabilize the local DNA/RNA secondary structures, these structural transitions may affect the gene expression by a change in the protein-DNA recognition patterns.

  18. Mental wellbeing amongst younger and older migrant workers in comparison to their urban counterparts in Guangzhou city, China: a cross-sectional study.

    Science.gov (United States)

    Li, Jie; Chang, Shu-Sen; Yip, Paul S F; Li, Juan; Jordan, Lucy P; Tang, Yunge; Hao, Yuantao; Huang, Xingmei; Yang, Ning; Chen, Chaoqi; Zeng, Qiaomei

    2014-12-16

    There has been a dramatic increase in internal migrant workers in China over recent decades, and there is a recent concern of poor mental health particularly amongst younger or "new generation" migrants who were born in 1980 or later. A cross-sectional study was conducted in Guangzhou city between May and July in 2012. Mental wellbeing was measured using the World Health Organization Five-item Well-Being Index Scale and the 36 Item Short Form Health Survey mental health scale. Linear and logistic regression models were used to investigate the differences between migrant workers and their urban counterparts and between younger and older migrants. Migrant workers (n = 914) showed a small but significant advantage in mental wellbeing compared to their urban counterparts (n = 814). There was some evidence for age modification effect (p for interaction = 0.055-0.095); better mental wellbeing in migrants than urbanites were mainly seen in the older compared to the younger group, and the difference attenuated somewhat after controlling for income satisfaction. Older migrants showed better mental health than younger migrants. Factors that were independently associated with poor mental health in migrants included being male, longer working hours, and income dissatisfaction, whilst older age, factory job, high income, and increased use of social support resources were associated with reduced risk. Efforts to promote mental health amongst migrant workers may be usefully targeted on younger migrants and include measures aimed to improve working conditions, strengthen the social support network, and address age-specific needs.

  19. Molecular alterations in lesions of anogenital mammary-like glands and their mammary counterparts including hidradenoma papilliferum, intraductal papilloma, fibroadenoma and phyllodes tumor.

    Science.gov (United States)

    Konstantinova, Anastasia M; Vanecek, Tomas; Martinek, Petr; Kyrpychova, Liubov; Spagnolo, Dominic V; Stewart, Colin J R; Portelli, Francesca; Michal, Michal; Kazakov, Dmitry V

    2017-06-01

    Lesions affecting anogenital mammary-like glands (AGMLG) are histopathologically very similar to those seen in the breast but whether this morphological similarity is also reflected at the genetic level is unknown. To compare the underlying molecular mechanisms in lesions of AGMLG and their mammary counterparts, we analyzed the mutational profile of 16 anogenital neoplasms including 5 hidradenomas papilliferum (HP), 1 lesion with features of HP and fibroadenoma (FA), 7 FA, 3 phyllodes tumors (PhT)) and 18 analogous breast lesions (6 intraductal papillomas (IDP), 9 FA, and 3 PhT) by high-coverage next generation sequencing (NGS) using a panel comprising 50 cancer-related genes. Additionally, all cases were analyzed for the presence of a mutation in the MED12 gene. All detected mutations with allele frequencies over 20% were independently validated by Sanger sequencing (concordance: 100%). Mutations in PIK3CA, AKT1, MET, ABL1 and TP53 genes were found in lesions of AGMLG and also their mammary counterparts. The PI3K-AKT cascade plays a role in tumors arising at both sites. It appears that some histopathologically similar anogenital and breast lesions develop along similar molecular pathways. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. Discovery of the near-infrared counterpart to the luminous neutron-star low-mass X-ray binary GX 3+1

    Energy Technology Data Exchange (ETDEWEB)

    Van den Berg, Maureen; Fridriksson, Joel K. [Anton Pannekoek Institute for Astronomy, University of Amsterdam, Science Park 904, 1098 XH Amsterdam (Netherlands); Homan, Jeroen [Massachusetts Institute of Technology, Kavli Institute for Astrophysics and Space Research, 70 Vassar Street, Cambridge, MA 02139 (United States); Linares, Manuel, E-mail: M.C.vandenBerg@uva.nl [Instituto de Astrofísica de Canarias (IAC), Vía Láctea s/n, La Laguna, E-38205, S/C de Tenerife (Spain)

    2014-10-01

    Using the High Resolution Camera on board the Chandra X-ray Observatory, we have measured an accurate position for the bright persistent neutron star X-ray binary and atoll source GX 3+1. At a location that is consistent with this new position, we have discovered the near-infrared (NIR) counterpart to GX 3+1 in images taken with the PANIC and FourStar cameras on the Magellan Baade Telescope. The identification of this K{sub s} = 15.8 ± 0.1 mag star as the counterpart is based on the presence of a Br γ emission line in an NIR spectrum taken with the Folded-port InfraRed Echelette spectrograph on the Baade Telescope. The absolute magnitude derived from the best available distance estimate to GX 3+1 indicates that the mass donor in the system is not a late-type giant. We find that the NIR light in GX 3+1 is likely dominated by the contribution from a heated outer accretion disk. This is similar to what has been found for the NIR flux from the brighter class of Z sources, but unlike the behavior of atolls fainter (L{sub X} ≈ 10{sup 36}-10{sup 37} erg s{sup –1}) than GX 3+1, where optically thin synchrotron emission from a jet probably dominates the NIR flux.

  1. Obsessive-compulsive disorder; chronic versus non-chronic symptoms

    NARCIS (Netherlands)

    Visser, H.A.; van Oppen, P.C.; van Megen, H.J.; Eikelenboom, M.; van Balkom, A.J.L.M.

    2014-01-01

    Objective Understanding chronicity in OCD is hampered by contradictory findings arising from dissimilar definitions of chronic OCD. The purpose of this study was to investigate the magnitude of chronicity in OCD and to examine if chronic OCD is critically different from non-chronic OCD, using a

  2. Chronic pelvic pain.

    Science.gov (United States)

    Stein, Sharon L

    2013-12-01

    Chronic pelvic pain is pain lasting longer than 6 months and is estimated to occur in 15% of women. Causes of pelvic pain include disorders of gynecologic, urologic, gastroenterologic, and musculoskeletal systems. The multidisciplinary nature of chronic pelvic pain may complicate diagnosis and treatment. Treatments vary by cause but may include medicinal, neuroablative, and surgical treatments. Copyright © 2013 Elsevier Inc. All rights reserved.

  3. Battling Chronic Absenteeism

    Science.gov (United States)

    Nauer, Kim

    2016-01-01

    While the principal of a New York elementary school (P.S. 48) took on chronic absenteeism from 2011 to 2013, a research team at the Center for New York City Affairs followed her efforts. The school drove down chronic absenteeism almost 10 percentage points. School staff routinely touched base with students, outside "success mentors"…

  4. The role of chronic prostatic inflammation in the pathogenesis and progression of benign prostatic hyperplasia (BPH).

    Science.gov (United States)

    Gandaglia, Giorgio; Briganti, Alberto; Gontero, Paolo; Mondaini, Nicola; Novara, Giacomo; Salonia, Andrea; Sciarra, Alessandro; Montorsi, Francesco

    2013-08-01

    Several different stimuli may induce chronic prostatic inflammation, which in turn would lead to tissue damage and continuous wound healing, thus contributing to prostatic enlargement. Patients with chronic inflammation and benign prostatic hyperplasia (BPH) have been shown to have larger prostate volumes, more severe lower urinary tract symptoms (LUTS) and a higher probability of acute urinary retention than their counterparts without inflammation. Chronic inflammation could be a predictor of poor response to BPH medical treatment. Thus, the ability to identify patients with chronic inflammation would be crucial to prevent BPH progression and develop target therapies. Although the histological examination of prostatic tissue remains the only available method to diagnose chronic inflammation, different parameters, such as prostatic calcifications, prostate volume, LUTS severity, storage and prostatitis-like symptoms, poor response to medical therapies and urinary biomarkers, have been shown to be correlated with chronic inflammation. The identification of patients with BPH and chronic inflammation might be crucial in order to develop target therapies to prevent BPH progression. In this context, clinical, imaging and laboratory parameters might be used alone or in combination to identify patients that harbour chronic prostatic inflammation. © 2013 BJU International.

  5. Testing for Chronic Diarrhea.

    Science.gov (United States)

    Raman, M

    Chronic diarrhea is a frequently encountered symptom in clinical practice. The etiologies for chronic diarrhea are diverse and broad with varying clinical implications. A useful method of categorizing chronic diarrhea to guide a diagnostic work-up is a pathophysiology-based framework. Chronic diarrhea may be categorized as malabsorptive, secretory, osmotic, and inflammatory or motility related. Frequently, overlap between categories may exist for any given diarrhea etiology and diagnostic testing must occur with an understanding of the differential diagnosis. Investigations to achieve a diagnosis for chronic diarrhea range from screening blood and stool tests to more directed testing such as diagnostic imaging, and endoscopic and histological evaluation. The pathophysiology-based framework proposed in this chapter will allow the clinician to select screening tests followed by targeted tests to minimize cost and complications to the patient, while providing a highly effective method to achieve an accurate diagnosis. © 2017 Elsevier Inc. All rights reserved.

  6. Chronic gastritis - an update.

    Science.gov (United States)

    Varbanova, Mariya; Frauenschläger, Katrin; Malfertheiner, Peter

    2014-12-01

    Helicobacter pylori is the main aetiologic factor for chronic gastritis worldwide. The degree of inflammation and the evolution of this form of chronic gastritis can vary largely depending on bacterial virulence factors, host susceptibility factors and environmental conditions. Autoimmune gastritis is another cause of chronic inflammation in the stomach, which can occur in all age groups. This disease presents typically with vitamin B12 deficiency and pernicious anaemia. The presence of anti-parietal cell antibodies is highly specific for the diagnosis. The role of H. pylori as a trigger for autoimmune gastritis remains uncertain. Other rare conditions for chronic gastritis are chronic inflammatory conditions such as Crohn's disease or on the background of lymphocytic or collagenous gastroenteropathies. Copyright © 2014. Published by Elsevier Ltd.

  7. Comparing the mental health of rural-to-urban migrant children and their counterparts in china: Protocol for a systematic review and meta-analysis.

    Science.gov (United States)

    Zhang, Jun-Hua; Yan, Li-Xia; Yuan, Yang

    2018-04-01

    In recent years, the issue of migrant children with peasant parents working in cities has attracted widespread attention in recent years because of the sheer number and the benefits bundled in China's household. The focus has gradually extended from early education opportunities to all aspects of physical and mental development, especially the social adaptation and mental health of migrant children. The negative impact of environment changes on migrant children' mental health is very worrying for parents and the society. Some studies have found that immigrant children's mental health is significantly lower than their peers, but there are also studies that hold the opposite view. Thus, the mental health status of migrant children is still a controversial issue, which may have a certain relationship with the potential differences in the specific problems of mental health, regions, comparison objects, and researchers. The objective of this protocol is to investigate whether mental health and subdimensions differ between rural-to-urban migrant children and their counterparts living in China and examine study characteristics that might result in differences among studies. We will search PubMed, Embase, OVID, ERIC, Web of Science, and Chinese databases including CNKI, Chongqing VIP, and Wan Fang data from start to April 2018. Cross-sectional studies with a comparison of migrant children and their counterparts will be included. The primary outcome will be the mean and standard deviation of mental health and its sub-dimensions. Standardized mean difference is used as the main effect value. Subgroup analyses will be carried out by the location of studies and school type of. Sensitivity analyses will be conducted to assess the robustness of the findings. Analyses will be performed with RevMan and Stata software. This systematic review and meta-analysis will compare the mental health status of rural-to-urban migrant children and their counterparts living in China. The results

  8. Stages of Chronic Myelogenous Leukemia

    Science.gov (United States)

    ... ALL Treatment Childhood AML Treatment Research Chronic Myelogenous Leukemia Treatment (PDQ®)–Patient Version General Information About Chronic Myelogenous Leukemia Go to Health Professional Version Key Points Chronic ...

  9. Estimating detection rates for the LIGO-Virgo search for gravitational-wave burst counterparts to gamma-ray bursts using inferred local GRB rates

    International Nuclear Information System (INIS)

    Leonor, I; Frey, R; Sutton, P J; Jones, G; Marka, S; Marka, Z

    2009-01-01

    One of the ongoing searches performed using the LIGO-Virgo network of gravitational-wave interferometers is the search for gravitational-wave burst (GWB) counterparts to gamma-ray bursts (GRBs). This type of analysis makes use of GRB time and position information from gamma-ray satellite detectors to trigger the GWB search, and the GWB detection rates possible for such an analysis thus strongly depend on the GRB detection efficiencies of the satellite detectors. Using local GRB rate densities inferred from observations which are found in the science literature, we calculate estimates of the GWB detection rates for different configurations of the LIGO-Virgo network for this type of analysis.

  10. Russia needs a strong counterpart

    International Nuclear Information System (INIS)

    Slovak, K.; Marcan, P.

    2008-01-01

    In this paper an interview with the head of OMV, Wolfgang Ruttenstorfer is published. There is extract from this interview: Q: There have been attempts to take over MOL for a quite long time. Do you think you can still succeed? Since the beginning we kept saying that this would not happen from one day to another. But it may take two to three years. But we are positive that it is justified. Q: Resistance from MOL and the Hungarian government is strong. We have tried to persuade the Hungarian government. We offered them a split company management. A part of the management would be in Budapest. We would locate the management of the largest division - the refinery, there. And of course only the best could be part of the management. We would not nominate people according to their nationality, it would not matter whether the person was Austrian, Hungarian or Slovak. We want a Central European company, not Hungarian, Romanian or Slovak company. Q: Would the transaction still be attractive if, because of pressure exercised by Brussels, you had to sell Slovnaft or your refinery in Szazhalobatta? We do not intend to sell any refineries. Q: Rumours are spreading that the Commission may ask you to sell a refinery? We do not want to speculate. Let us wait and see what happens. We do not want to sell refineries. Q: It is said that OMV is coordinating or at least consulting its attempts to acquire MOL with Gazprom. There are many rumours in Central Europe. But I can tell you this is not true. We are interested in this merger because we feel the increasing pressure exercised by Kazakhstan and Russia. We, of course, have a good relationship with Gazprom which we have had enjoyed for over forty years. As indeed Slovakia has. Q: A few weeks ago Austrian daily Wirtschaftsblatt published an article about Gazprom's interest in OMV shares. That is gossip that is more than ten years' old. Similarly to the rumours that Gazprom is a shareholder of MOL. There are no negotiations with Gazprom and no plans to start any. Q: And how can you be sure that the merged OMV/MOL will not end in Russian hands? We have two majority shareholders. The Austrian state and the investment holding Abu Dhabi IPIC. And long term contracts on them remaining majority shareholders have been signed. In addition OMV has major investments with Abu Dhabi. For instance a big ethylene cracking project. And you can believe me that the emirate does not want a different shareholder structure in OMV

  11. The Electromagnetic Counterpart of the Binary Neutron Star Merger LIGO/Virgo GW170817. VII. Properties of the Host Galaxy and Constraints on the Merger Timescale

    Science.gov (United States)

    Blanchard, P. K.; Berger, E.; Fong, W.; Nicholl, M.; Leja, J.; Conroy, C.; Alexander, K. D.; Margutti, R.; Williams, P. K. G.; Doctor, Z.; Chornock, R.; Villar, V. A.; Cowperthwaite, P. S.; Annis, J.; Brout, D.; Brown, D. A.; Chen, H.-Y.; Eftekhari, T.; Frieman, J. A.; Holz, D. E.; Metzger, B. D.; Rest, A.; Sako, M.; Soares-Santos, M.

    2017-10-01

    We present the properties of NGC 4993, the host galaxy of GW170817, the first gravitational-wave (GW) event from the merger of a binary neutron star (BNS) system and the first with an electromagnetic (EM) counterpart. We use both archival photometry and new optical/near-IR imaging and spectroscopy, together with stellar population synthesis models to infer the global properties of the host galaxy. We infer a star formation history peaked at ≳ 10 {Gyr} ago, with subsequent exponential decline leading to a low current star formation rate of 0.01 {M}⊙ yr-1, which we convert into a binary merger timescale probability distribution. We find a median merger timescale of {11.2}-1.4+0.7 Gyr, with a 90% confidence range of 6.8{--}13.6 {Gyr}. This in turn indicates an initial binary separation of ≈ 4.5 {R}⊙ , comparable to the inferred values for Galactic BNS systems. We also use new and archival Hubble Space Telescope images to measure a projected offset of the optical counterpart of 2.1 kpc (0.64r e ) from the center of NGC 4993 and to place a limit of {M}r≳ -7.2 mag on any pre-existing emission, which rules out the brighter half of the globular cluster luminosity function. Finally, the age and offset of the system indicates it experienced a modest natal kick with an upper limit of ˜200 km s-1. Future GW-EM observations of BNS mergers will enable measurement of their population delay time distribution, which will directly inform their viability as the dominant source of r-process enrichment in the universe.

  12. South Asian women with polycystic ovary syndrome exhibit greater sensitivity to gonadotropin stimulation with reduced fertilization and ongoing pregnancy rates than their Caucasian counterparts.

    Science.gov (United States)

    Palep-Singh, M; Picton, H M; Vrotsou, K; Maruthini, D; Balen, A H

    2007-10-01

    Polycystic ovary syndrome (PCOS) is a heterogeneous syndrome. In vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) is required for PCOS cases that are refractory to standard ovulation induction or have co-existing infertility factors in women with PCOS and Tubal factor subfertility. Assess ethnic variations in response to IVF/ICSI treatment. Observational Comparative study in a University hospital fertility clinic in women with PCOS and Tubal factor subfertility. Women with PCOS (Asians: AP=104; Caucasians: CP=220) and those with tubal factor infertility seeking fertility treatment were assessed (Asians: AC=84; Caucasians: CC=200). Six hundred and eight fresh IVF or ICSI cycles using long protocol of GnRHa suppression and resulting in a fresh embryo transfer were compared. The primary endpoint was to assess the dose of gonadotropins used in the cycles. The secondary outcomes were: total number of oocytes retrieved, fertilization and ongoing clinical pregnancy rates. We found that the South Asian women presented at a younger age for the management of sub-fertility. An extended stimulation phase and Caucasian ethnicity showed an inverse correlation with the number of oocytes retrieved in the PCOS subgroup. Caucasian ethnicity was associated with a higher fertilization rate however increase in body mass index (BMI) and the laboratory technique of IVF appeared to have a negative impact on fertilization rates in the PCOS subgroup. Commencing down regulation on day 1 of the cycles was negatively associated with fertilization rates in the tubal group. In terms of clinical pregnancy rates, the Caucasian PCOS had a 2.5 times (95% CI: 1.25-5) higher chance of an ongoing clinical pregnancy as compared with their Asian counterpart. Also, a unit increase in the basal FSH concentration reduced the odds of pregnancy by 18.6% (95% CI: 1.8-32.6%) in the PCOS group. The Asian PCOS have a greater sensitivity to gonadotropin stimulation with lower fertilization and

  13. The Electromagnetic Counterpart of the Binary Neutron Star Merger LIGO/Virgo GW170817. VII. Properties of the Host Galaxy and Constraints on the Merger Timescale

    Energy Technology Data Exchange (ETDEWEB)

    Blanchard, P. K.; Berger, E.; Fong, W.; Nicholl, M.; Leja, J.; Conroy, C.; Alexander, K. D.; Margutti, R.; Williams, P. K. G.; Doctor, Z.; Chornock, R.; Villar, V. A.; Cowperthwaite, P. S.; Annis, J.; Brout, D.; Brown, D. A.; Chen, H. -Y.; Eftekhari, T.; Frieman, J. A.; Holz, D. E.; Metzger, B. D.; Rest, A.; Sako, M.; Soares-Santos, M.

    2017-10-16

    We present the properties of NGC 4993, the host galaxy of GW170817, the first gravitational wave (GW) event from the merger of a binary neutron star (BNS) system and the first with an electromagnetic (EM) counterpart. We use both archival photometry and new optical/near-IR imaging and spectroscopy, together with stellar population synthesis models to infer the global properties of the host galaxy. We infer a star formation history peaked at $\\gtrsim 10$ Gyr ago, with subsequent exponential decline leading to a low current star formation rate of 0.01 M$_{\\odot}$ yr$^{-1}$, which we convert into a binary merger timescale probability distribution. We find a median merger timescale of $11.2^{+0.7}_{-1.4}$ Gyr, with a 90% confidence range of $6.8-13.6$ Gyr. This in turn indicates an initial binary separation of $\\approx 4.5$ R$_{\\odot}$, comparable to the inferred values for Galactic BNS systems. We also use new and archival $Hubble$ $Space$ $Telescope$ images to measure a projected offset of the optical counterpart of $2.1$ kpc (0.64$r_{e}$) from the center of NGC 4993 and to place a limit of $M_{r} \\gtrsim -7.2$ mag on any pre-existing emission, which rules out the brighter half of the globular cluster luminosity function. Finally, the age and offset of the system indicates it experienced a modest natal kick with an upper limit of $\\sim 200$ km s$^{-1}$. Future GW$-$EM observations of BNS mergers will enable measurement of their population delay time distribution, which will directly inform their viability as the dominant source of $r$-process enrichment in the Universe.

  14. Chronic hypersensitivity pneumonitis.

    Science.gov (United States)

    Pereira, Carlos Ac; Gimenez, Andréa; Kuranishi, Lilian; Storrer, Karin

    2016-01-01

    Hypersensitivity pneumonitis (HSP) is a common interstitial lung disease resulting from inhalation of a large variety of antigens by susceptible individuals. The disease is best classified as acute and chronic. Chronic HSP can be fibrosing or not. Fibrotic HSP has a large differential diagnosis and has a worse prognosis. The most common etiologies for HSP are reviewed. Diagnostic criteria are proposed for both chronic forms based on exposure, lung auscultation, lung function tests, HRCT findings, bronchoalveolar lavage, and biopsies. Treatment options are limited, but lung transplantation results in greater survival in comparison to idiopathic pulmonary fibrosis. Randomized trials with new antifibrotic agents are necessary.

  15. Chronic neutrophilic leukemia.

    Science.gov (United States)

    Bredeweg, Arthur; Burch, Micah; Krause, John R

    2018-01-01

    Chronic neutrophilic leukemia is a rare myeloproliferative disorder characterized by a sustained peripheral blood neutrophilia, absence of the BCR/ABL oncoprotein, bone marrow hypercellularity with less than 5% myeloblasts and normal neutrophil maturation, and no dysplasia. This leukemia has been associated with mutations in the colony-stimulating factor 3 receptor (CSF3R) that may activate this receptor, leading to the proliferation of neutrophils that are the hallmark of chronic neutrophilic leukemia. We present a case of chronic neutrophilic leukemia and discuss the criteria for diagnosis and the significance of mutations found in this leukemia.

  16. Chronic Conditions Dashboard

    Data.gov (United States)

    U.S. Department of Health & Human Services — The CMS Chronic Conditions Dashboard presents statistical views of information on the prevalence, utilization and Medicare spending for Medicare beneficiaries with...

  17. About Chronic Kidney Disease

    Science.gov (United States)

    ... detect CKD: blood pressure, urine albumin and serum creatinine. What causes CKD? The two main causes of chronic kidney disease are diabetes and high blood pressure , which are responsible for up to ...

  18. Low back pain - chronic

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/007422.htm Low back pain - chronic To use the sharing features on this page, please enable JavaScript. Low back pain refers to pain that you feel in your ...

  19. Chronic Condition Data Warehouse

    Data.gov (United States)

    U.S. Department of Health & Human Services — The CMS Chronic Condition Data Warehouse (CCW) provides researchers with Medicare and Medicaid beneficiary, claims, and assessment data linked by beneficiary across...

  20. People Experiencing Chronic Homelessness

    Science.gov (United States)

    ... People with Disabilities Share Ending Chronic Homelessness Among People with Disabilities Last updated on May 31, 2018 We can end homelessness for people with disabilities in our communities who experience recurring ...

  1. Dealing with chronic cancer

    Science.gov (United States)

    ... enjoying the present instead of worrying about the future. Focus on the small things that bring you ... E. The chronic leukemias. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine . 25th ed. Philadelphia, PA: ...

  2. Chronic Conditions PUF

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Chronic Conditions PUFs are aggregated files in which each record is a profile or cell defined by the characteristics of Medicare beneficiaries. A profile is...

  3. CHRONIC UNEXPLAINED OROFACIAL PAIN

    Directory of Open Access Journals (Sweden)

    Aleš Vesnaver

    2002-04-01

    Full Text Available Background. Chronic unexplained orofacial pain is frequently the cause of prolonged suffering for the patient and an unsolvable problem for the therapist. Pathophysiology of the onset of this type of pain is virtually unknown. Still, it is possible to divide chronic orofacial pain into several separate categories, according to its onset, symptoms and therapy. All forms of this type of pain have a strong psychological component.Methods. A retrograde review was conducted, in which patients’ records, treated in 1994 for chronic unexplained orofacial pain, were followed through a 5 year period. The modalities of treatment then and at present were compared.Conclusions. Except for trigeminal neuralgia, where carbamazepine remains the first choice drug, treatment of chronic facial pain has changed considerably.

  4. Chronic Kidney Disease

    Science.gov (United States)

    You have two kidneys, each about the size of your fist. Their main job is to filter your blood. They remove wastes and ... help control blood pressure, and make hormones. Chronic kidney disease (CKD) means that your kidneys are damaged ...

  5. Chronic inflammatory demyelinative polyneuropathy

    DEFF Research Database (Denmark)

    Said, Gérard; Krarup, Christian

    2013-01-01

    Chronic inflammatory demyelinative polyneuropathy (CIDP) is an acquired polyneuropathy presumably of immunological origin. It is characterized by a progressive or a relapsing course with predominant motor deficit. The diagnosis rests on the association of non-length-dependent predominantly motor...

  6. Chronic Hypertension in Pregnancy

    Science.gov (United States)

    ... org/ by guest on June 19, 2018 Chronic Hypertension in Pregnancy Ellen W. Seely, MD; Cynthia Maxwell, ... M any women have been diag- nosed with hypertension (blood pressure Ͼ 140/ 90 mm Hg) when ...

  7. Chronic heart failure

    OpenAIRE

    Hopper, Ingrid; Easton, Kellie

    2017-01-01

    1. The common symptoms and signs of chronic heart failure are dyspnoea, ankle swelling, raised jugular venous pressure and basal crepitations. Other conditions may be confused with chronic heart failure, including dependent oedema or oedema due to renal or hepatic disease. Shortness of breath may be due to respiratory disease or severe anaemia. Heart failure secondary to lung disease (cor pulmonale) should be distinguished from congestive cardiac failure. Heart failure may also present with l...

  8. The Electromagnetic Counterpart of the Binary Neutron Star Merger LIGO/Virgo GW170817. II. UV, Optical, and Near-infrared Light Curves and Comparison to Kilonova Models

    Energy Technology Data Exchange (ETDEWEB)

    Cowperthwaite, P. S.; Berger, E.; Villar, V. A.; Metzger, B. D.; Nicholl, M.; Chornock, R.; Blanchard, P. K.; Fong, W.; Margutti, R.; Soares-Santos, M.; Alexander, K. D.; Allam, S.; Annis, J.; Brout, D.; Brown, D. A.; Butler, R. E.; Chen, H. -Y.; Diehl, H. T.; Doctor, Z.; Drout, M. R.; Eftekhari, T.; Farr, B.; Finley, D. A.; Foley, R. J.; Frieman, J. A.; Fryer, C. L.; García-Bellido, J.; Gill, M. S. S.; Guillochon, J.; Herner, K.; Holz, D. E.; Kasen, D.; Kessler, R.; Marriner, J.; Matheson, T.; Neilsen, E. H.; Quataert, E.; Palmese, A.; Rest, A.; Sako, M.; Scolnic, D. M.; Smith, N.; Tucker, D. L.; Williams, P. K. G.; Balbinot, E.; Carlin, J. L.; Cook, E. R.; Durret, F.; Li, T. S.; Lopes, P. A. A.; Lourenço, A. C. C.; Marshall, J. L.; Medina, G. E.; Muir, J.; Muñoz, R. R.; Sauseda, M.; Schlegel, D. J.; Secco, L. F.; Vivas, A. K.; Wester, W.; Zenteno, A.; Zhang, Y.; Abbott, T. M. C.; Banerji, M.; Bechtol, K.; Benoit-Lévy, A.; Bertin, E.; Buckley-Geer, E.; Burke, D. L.; Capozzi, D.; Carnero Rosell, A.; Carrasco Kind, M.; Castander, F. J.; Crocce, M.; Cunha, C. E.; D’Andrea, C. B.; Costa, L. N. da; Davis, C.; DePoy, D. L.; Desai, S.; Dietrich, J. P.; Drlica-Wagner, A.; Eifler, T. F.; Evrard, A. E.; Fernandez, E.; Flaugher, B.; Fosalba, P.; Gaztanaga, E.; Gerdes, D. W.; Giannantonio, T.; Goldstein, D. A.; Gruen, D.; Gruendl, R. A.; Gutierrez, G.; Honscheid, K.; Jain, B.; James, D. J.; Jeltema, T.; Johnson, M. W. G.; Johnson, M. D.; Kent, S.; Krause, E.; Kron, R.; Kuehn, K.; Nuropatkin, N.; Lahav, O.; Lima, M.; Lin, H.; Maia, M. A. G.; March, M.; Martini, P.; McMahon, R. G.; Menanteau, F.; Miller, C. J.; Miquel, R.; Mohr, J. J.; Neilsen, E.; Nichol, R. C.; Ogando, R. L. C.; Plazas, A. A.; Roe, N.; Romer, A. K.; Roodman, A.; Rykoff, E. S.; Sanchez, E.; Scarpine, V.; Schindler, R.; Schubnell, M.; Sevilla-Noarbe, I.; Smith, M.; Smith, R. C.; Sobreira, F.; Suchyta, E.; Swanson, M. E. C.; Tarle, G.; Thomas, D.; Thomas, R. C.; Troxel, M. A.; Vikram, V.; Walker, A. R.; Wechsler, R. H.; Weller, J.; Yanny, B.; Zuntz, J.

    2017-10-16

    We present UV, optical, and NIR photometry of the first electromagnetic counterpart to a gravitational wave source from Advanced LIGO/Virgo, the binary neutron star merger GW170817. Our data set extends from the discovery of the optical counterpart at $0.47$ days to $18.5$ days post-merger, and includes observations with the Dark Energy Camera (DECam), Gemini-South/FLAMINGOS-2 (GS/F2), and the {\\it Hubble Space Telescope} ({\\it HST}). The spectral energy distribution (SED) inferred from this photometry at $0.6$ days is well described by a blackbody model with $T\\approx 8300$ K, a radius of $R\\approx 4.5\\times 10^{14}$ cm (corresponding to an expansion velocity of $v\\approx 0.3c$), and a bolometric luminosity of $L_{\\rm bol}\\approx 5\\times10^{41}$ erg s$^{-1}$. At $1.5$ days we find a multi-component SED across the optical and NIR, and subsequently we observe rapid fading in the UV and blue optical bands and significant reddening of the optical/NIR colors. Modeling the entire data set we find that models with heating from radioactive decay of $^{56}$Ni, or those with only a single component of opacity from $r$-process elements, fail to capture the rapid optical decline and red optical/NIR colors. Instead, models with two components consistent with lanthanide-poor and lanthanide-rich ejecta provide a good fit to the data, the resulting "blue" component has $M_\\mathrm{ej}^\\mathrm{blue}\\approx 0.01$ M$_\\odot$ and $v_\\mathrm{ej}^\\mathrm{blue}\\approx 0.3$c, and the "red" component has $M_\\mathrm{ej}^\\mathrm{red}\\approx 0.04$ M$_\\odot$ and $v_\\mathrm{ej}^\\mathrm{red}\\approx 0.1$c. These ejecta masses are broadly consistent with the estimated $r$-process production rate required to explain the Milky Way $r$-process abundances, providing the first evidence that BNS mergers can be a dominant site of $r$-process enrichment.

  9. The NASA POWER SSE: Deriving the Direct Normal Counterpart from the CERES SYN1deg Hourly Global Horizontal Irradiance during Early 2000 to Near Present

    Science.gov (United States)

    Zhang, T.; Stackhouse, P. W., Jr.; Westberg, D. J.

    2017-12-01

    The NASA Prediction of Worldwide Energy Resource (POWER) Surface meteorology and Solar Energy (SSE) provides solar direct normal irradiance (DNI) data as well as a variety of other solar parameters. The currently available DNIs are monthly means on a quasi-equal-area grid system with grid boxes roughly equivalent to 1 degree longitude by 1 degree latitude around the equator from July 1983 to June 2005, and the data were derived from the GEWEX Surface Radiation Budget (SRB) monthly mean global horizontal irradiance (GHI, Release 3) and regression analysis of the Baseline Surface Radiation Network (BSRN) data. To improve the quality of the DNI data and push the temporal coverage of the data to near present, we have applied a modified version of the DIRINDEX global-to-beam model to the GEWEX SRB (Release 3) all-sky and clear-sky 3-hourly GHI data and derived their DNI counterparts for the period from July 1983 to December 2007. The results have been validated against the BSRN data. To further expand the data in time to near present, we are now applying the DIRINDEX model to the Clouds and the Earth's Radiant Energy System (CERES) data. The CERES SYN1deg (Edition 4A) offers hourly all-sky and clear-sky GHIs on a 1 degree longitude by 1 degree latitude grid system from March 2000 to October 2016 as of this writing. Comparisons of the GHIs with their BSRN counterparts show remarkable agreements. Besides the GHIs, the inputs will also include the atmospheric water vapor and surface pressure from the Modern Era Retrospective-Analysis for Research and Applications (MERRA) and the aerosol optical depth from the Max-Planck Institute Climatology (MAC-v1). Based on the performance of the DIRINDEX model with the GEWEX SRB GHI data, we expect at least equally good or even better results. In this paper, we will show the derived hourly, daily, and monthly mean DNIs from the CERES SYN1deg hourly GHIs from March 2000 to October 2016 and how they compare with the BSRN data.

  10. Hereditary chronic pancreatitis

    Directory of Open Access Journals (Sweden)

    Mössner Joachim

    2007-01-01

    Full Text Available Abstract Hereditary chronic pancreatitis (HCP is a very rare form of early onset chronic pancreatitis. With the exception of the young age at diagnosis and a slower progression, the clinical course, morphological features and laboratory findings of HCP do not differ from those of patients with alcoholic chronic pancreatitis. As well, diagnostic criteria and treatment of HCP resemble that of chronic pancreatitis of other causes. The clinical presentation is highly variable and includes chronic abdominal pain, impairment of endocrine and exocrine pancreatic function, nausea and vomiting, maldigestion, diabetes, pseudocysts, bile duct and duodenal obstruction, and rarely pancreatic cancer. Fortunately, most patients have a mild disease. Mutations in the PRSS1 gene, encoding cationic trypsinogen, play a causative role in chronic pancreatitis. It has been shown that the PRSS1 mutations increase autocatalytic conversion of trypsinogen to active trypsin, and thus probably cause premature, intrapancreatic trypsinogen activation disturbing the intrapancreatic balance of proteases and their inhibitors. Other genes, such as the anionic trypsinogen (PRSS2, the serine protease inhibitor, Kazal type 1 (SPINK1 and the cystic fibrosis transmembrane conductance regulator (CFTR have been found to be associated with chronic pancreatitis (idiopathic and hereditary as well. Genetic testing should only be performed in carefully selected patients by direct DNA sequencing and antenatal diagnosis should not be encouraged. Treatment focuses on enzyme and nutritional supplementation, pain management, pancreatic diabetes, and local organ complications, such as pseudocysts, bile duct or duodenal obstruction. The disease course and prognosis of patients with HCP is unpredictable. Pancreatic cancer risk is elevated. Therefore, HCP patients should strongly avoid environmental risk factors for pancreatic cancer.

  11. ROSA/LSTF Test and RELAP5 Analyses on PWR Cold Leg Small-Break LOCA with Accident Management Measure and PKL Counterpart Test

    Energy Technology Data Exchange (ETDEWEB)

    Takeda, Takeshi; Ohtsu, Iwao [Nuclear Safety Research Center, Japan Atomic Energy Agency, Tokaimura (Japan)

    2017-08-15

    An experiment using the Primaerkreislaeufe Versuchsanlage (PKL) was performed for the OECD/NEA PKL-3 Project as a counterpart to a previous test with the large-scale test facility (LSTF) on a cold leg small-break loss-of-coolant accident with an accident management (AM) measure in a pressurized water reactor. Concerning the AM measure, the rate of steam generator (SG) secondary-side depressurization was controlled to achieve a primary depressurization rate of 200 K/h as a common test condition; however, the onset timings of the SG depressurization were different from each other. In both tests, rapid recovery started in the core collapsed liquid level after loop seal clearing, which caused whole core quench. Some discrepancies appeared between the LSTF and PKL test results for the core collapsed liquid level, the cladding surface temperature, and the primary pressure. The RELAP5/MOD3.3 code predicted the overall trends of the major thermal-hydraulic responses observed in the LSTF test well, and indicated a remaining problem in the prediction of primary coolant distribution. Results of uncertainty analysis for the LSTF test clarified the influences of the combination of multiple uncertain parameters on peak cladding temperature within the defined uncertain ranges.

  12. ROSA/LSTF Test and RELAP5 Analyses on PWR Cold Leg Small-Break LOCA with Accident Management Measure and PKL Counterpart Test

    Directory of Open Access Journals (Sweden)

    Takeshi Takeda

    2017-08-01

    Full Text Available An experiment using the Primӓrkreislӓufe Versuchsanlage (PKL was performed for the OECD/NEA PKL-3 Project as a counterpart to a previous test with the large-scale test facility (LSTF on a cold leg small-break loss-of-coolant accident with an accident management (AM measure in a pressurized water reactor. Concerning the AM measure, the rate of steam generator (SG secondary-side depressurization was controlled to achieve a primary depressurization rate of 200 K/h as a common test condition; however, the onset timings of the SG depressurization were different from each other. In both tests, rapid recovery started in the core collapsed liquid level after loop seal clearing, which caused whole core quench. Some discrepancies appeared between the LSTF and PKL test results for the core collapsed liquid level, the cladding surface temperature, and the primary pressure. The RELAP5/MOD3.3 code predicted the overall trends of the major thermal-hydraulic responses observed in the LSTF test well, and indicated a remaining problem in the prediction of primary coolant distribution. Results of uncertainty analysis for the LSTF test clarified the influences of the combination of multiple uncertain parameters on peak cladding temperature within the defined uncertain ranges.

  13. A comparison between SALT/SAAO observations and kilonova models for AT 2017gfo: the first electromagnetic counterpart of a gravitational wave transient - GW170817

    Science.gov (United States)

    Buckley, David A. H.; Andreoni, Igor; Barway, Sudhanshu; Cooke, Jeff; Crawford, Steven M.; Gorbovskoy, Evgeny; Gromadzki, Mariusz; Lipunov, Vladimir; Mao, Jirong; Potter, Stephen B.; Pretorius, Magaretha L.; Pritchard, Tyler A.; Romero-Colmenero, Encarni; Shara, Michael M.; Väisänen, Petri; Williams, Ted B.

    2018-02-01

    We report on SALT low-resolution optical spectroscopy and optical/IR photometry undertaken with other SAAO telescopes (MASTER-SAAO and IRSF) of the kilonova AT 2017gfo (a.k.a. SSS17a) in the galaxy NGC4993 during the first 10 d of discovery. This event has been identified as the first ever electromagnetic counterpart of a gravitational wave event, namely GW170817, which was detected by the LIGO and Virgo gravitational wave observatories. The event is likely due to a merger of two neutron stars, resulting in a kilonova explosion. SALT was the third observatory to obtain spectroscopy of AT 2017gfo and the first spectrum, 1.2 d after the merger, is quite blue and shows some broad features, but no identifiable spectral lines and becomes redder by the second night. We compare the spectral and photometric evolution with recent kilonova simulations and conclude that they are in qualitative agreement for post-merger wind models with proton:nucleon ratios of Ye = 0.25-0.30. The blue colour of the first spectrum is consistent with the lower opacity of the lanthanide-free r-process elements in the ejecta. Differences between the models and observations are likely due to the choice of system parameters combined with the absence of atomic data for more elements in the ejecta models.

  14. Amorphous/crystalline (A/C) thermodynamic "rules of thumb": estimating standard thermodynamic data for amorphous materials using standard data for their crystalline counterparts.

    Science.gov (United States)

    Holland, Diane; Jenkins, H Donald Brooke

    2012-05-07

    Standard thermochemical data (in the form of Δ(f)H° and Δ(f)G°) are available for crystalline (c) materials but rarely for their corresponding amorphous (a) counterparts. This paper establishes correlations between the sets of data for the two material forms (where known), which can then be used as a guideline for estimation of missing data. Accordingly, Δ(f)H°(a)/kJ mol(-1) ≈ 0.993Δ(f)H°(c)/kJ mol(-1) + 12.52 (R(2) = 0.9999; n = 50) and Δ(f)G°/kJ mol(-1) ≈ 0.988Δ(f)H°(c)/kJ mol(-1) + 0.70 (R(2) = 0.9999; n = 10). Much more tentatively, we propose that S°(298)(c)/J K(-1) mol(-1) ≈ 1.084S°(298)(c)/J K(-1) mol(-1) + 6.54 (R(2) = 0.9873; n = 11). An amorphous hydrate enthalpic version of the Difference Rule is also proposed (and tested) in the form [Δ(f)H°(M(p)X(q)·nH(2)O,a) - Δ(f)H°(M(p)X(q),a)]/kJ mol(-1) ≈ Θ(Hf)n ≈ -302.0n, where M(p)X(q)·nH(2)O represents an amorphous hydrate and M(p)X(q) the corresponding amorphous anhydrous parent salt.

  15. Dose fractionation effects in plateau-phase cultures of C3H 10T1/2 cells and their transformed counterparts

    International Nuclear Information System (INIS)

    Zeman, E.M.; Bedford, J.S.

    1985-01-01

    A comparison of γ-ray dose fractionation effects was made using plateau-phase cultures of C3H 10T1/2 cells and their transformed counterparts in an attempt to simulate basically similar populations of cells that differ primarily in their turnover rates. The status of cell populations with respect to their turnover rates may be an important factor influencing dose fractionation effects in early- and late-responding tissues. In this cell culture system, the rate of cell turnover was approximately three times higher for the plateau-phase transformed cultures. While the single acute dose survival curves for log-phase cells were indistinguishable, there were significant differences between the survival curves for plateau-phase cultures of the two cell types. Both cell lines had a similar capacity for repair of sublethal damage, but untransformed cells had a much greater capacity to repair potentially lethal damage in plateau phase. Multifraction survival curves were determined for both cell lines for doses per fraction ranging from 9.0 to 0.8 Gy, and from these isoeffect curves of log total dose versus dose per fraction were derived. The isoeffect curve for the slowly cycling, untransformed cells was found to be appreciably steeper than that for the more rapidly cycling transformed cells, a finding consistent with previously reported differences in dose fractionation isoeffect curves for early- and late-responding tissues in vivo

  16. Mesenchymal stem cells from cortical bone demonstrate increased clonal incidence, potency, and developmental capacity compared to their bone marrow–derived counterparts

    Directory of Open Access Journals (Sweden)

    Daniel Blashki

    2016-08-01

    Full Text Available In this study, we show that matrix dense cortical bone is the more potent compartment of bone than bone marrow as a stromal source for mesenchymal stem cells as isolated from adult rats. Lineage-depleted cortical bone-mesenchymal stem cells demonstrated >150-fold enrichment of colony forming unit–fibroblasts per cell incidence. compared to lineage-depleted bone marrow-mesenchymal stem cells, corresponding to a 70-fold increase in absolute recovered colony forming unit–fibroblasts. The composite phenotype Lin−/CD45−/CD31−/VLA-1+/Thy-1+ enriched for clonogenic mesenchymal stem cells solely from cortical bone–derived cells from which 70% of clones spontaneously differentiated into all lineages of bone, cartilage, and adipose. Both populations generated vascularized bone tissue within subcutaneous implanted collagen scaffolds; however, cortical bone–derived cells formed significantly more osteoid than bone marrow counterparts, quantified by histology. The data demonstrate that our isolation protocol identifies and validates mesenchymal stem cells with superior clonal, proliferative, and developmental potential from cortical bone compared to the bone marrow niche although marrow persists as the typical source for mesenchymal stem cells both in the literature and current pre-clinical therapies.

  17. Identification of cis-acting elements on positive-strand subgenomic mRNA required for the synthesis of negative-strand counterpart in bovine coronavirus.

    Science.gov (United States)

    Yeh, Po-Yuan; Wu, Hung-Yi

    2014-07-30

    It has been demonstrated that, in addition to genomic RNA, sgmRNA is able to serve as a template for the synthesis of the negative-strand [(-)-strand] complement. However, the cis-acting elements on the positive-strand [(+)-strand] sgmRNA required for (-)-strand sgmRNA synthesis have not yet been systematically identified. In this study, we employed real-time quantitative reverse transcription polymerase chain reaction to analyze the cis-acting elements on bovine coronavirus (BCoV) sgmRNA 7 required for the synthesis of its (-)-strand counterpart by deletion mutagenesis. The major findings are as follows. (1) Deletion of the 5'-terminal leader sequence on sgmRNA 7 decreased the synthesis of the (-)-strand sgmRNA complement. (2) Deletions of the 3' untranslated region (UTR) bulged stem-loop showed no effect on (-)-strand sgmRNA synthesis; however, deletion of the 3' UTR pseudoknot decreased the yield of (-)-strand sgmRNA. (3) Nucleotides positioned from -15 to -34 of the sgmRNA 7 3'-terminal region are required for efficient (-)-strand sgmRNA synthesis. (4) Nucleotide species at the 3'-most position (-1) of sgmRNA 7 is correlated to the efficiency of (-)-strand sgmRNA synthesis. These results together suggest, in principle, that the 5'- and 3'-terminal sequences on sgmRNA 7 harbor cis-acting elements are critical for efficient (-)-strand sgmRNA synthesis in BCoV.

  18. Comparative Proteomic Analysis of Two Varieties of Genetically Modified (GM) Embrapa 5.1 Common Bean (Phaseolus vulgaris L.) and Their Non-GM Counterparts.

    Science.gov (United States)

    Balsamo, Geisi M; Valentim-Neto, Pedro A; Mello, Carla S; Arisi, Ana C M

    2015-12-09

    The genetically modified (GM) common bean event Embrapa 5.1 was commercially approved in Brazil in 2011; it is resistant to golden mosaic virus infection. In the present work grain proteome profiles of two Embrapa 5.1 common bean varieties, Pérola and Pontal, and their non-GM counterparts were compared by two-dimensional gel electrophoresis (2-DE) followed by mass spectrometry (MS). Analyses detected 23 spots differentially accumulated between GM Pérola and non-GM Pérola and 21 spots between GM Pontal and non-GM Pontal, although they were not the same proteins in Pérola and Pontal varieties, indicating that the variability observed may not be due to the genetic transformation. Among them, eight proteins were identified in Pérola varieties, and four proteins were identified in Pontal. Moreover, we applied principal component analysis (PCA) on 2-DE data, and variation between varieties was explained in the first two principal components. This work provides a first 2-DE-MS/MS-based analysis of Embrapa 5.1 common bean grains.

  19. Autoantibodies in chronic pancreatitis

    DEFF Research Database (Denmark)

    Rumessen, J J; Marner, B; Pedersen, N T

    1985-01-01

    In 60 consecutive patients clinically suspected of having chronic pancreatitis the serum concentration of the immunoglobulins (IgA, IgG, IgM), the IgG- and IgA-type non-organ-specific autoantibodies against nuclear material (ANA), smooth and striated muscle, mitochondria, basal membrane, and reti......In 60 consecutive patients clinically suspected of having chronic pancreatitis the serum concentration of the immunoglobulins (IgA, IgG, IgM), the IgG- and IgA-type non-organ-specific autoantibodies against nuclear material (ANA), smooth and striated muscle, mitochondria, basal membrane......, and reticulin, and the IgG- and IgA-type pancreas-specific antibodies against islet cells, acinus cells, and ductal cells (DA) were estimated blindly. In 23 of the patients chronic pancreatitis was verified, whereas chronic pancreatitis was rejected in 37 patients (control group). IgG and IgA were found...... in significantly higher concentrations in the patients with chronic pancreatitis than in the control group but within the normal range. ANA and DA occurred very frequently in both groups but with no statistical difference. Other autoantibodies only occurred sporadically. The findings of this study do not support...

  20. Chronic daily headaches

    Directory of Open Access Journals (Sweden)

    Fayyaz Ahmed

    2012-01-01

    Full Text Available Chronic Daily Headache is a descriptive term that includes disorders with headaches on more days than not and affects 4% of the general population. The condition has a debilitating effect on individuals and society through direct cost to healthcare and indirectly to the economy in general. To successfully manage chronic daily headache syndromes it is important to exclude secondary causes with comprehensive history and relevant investigations; identify risk factors that predict its development and recognise its sub-types to appropriately manage the condition. Chronic migraine, chronic tension-type headache, new daily persistent headache and medication overuse headache accounts for the vast majority of chronic daily headaches. The scope of this article is to review the primary headache disorders. Secondary headaches are not discussed except medication overuse headache that often accompanies primary headache disorders. The article critically reviews the literature on the current understanding of daily headache disorders focusing in particular on recent developments in the treatment of frequent headaches.

  1. The consequences of chronic stereotype threat: domain disidentification and abandonment.

    Science.gov (United States)

    Woodcock, Anna; Hernandez, Paul R; Estrada, Mica; Schultz, P Wesley

    2012-10-01

    Stereotype threat impairs performance across many domains. Despite a wealth of research, the long-term consequences of chronic stereotype threat have received little empirical attention. Beyond the immediate impact on performance, the experience of chronic stereotype threat is hypothesized to lead to domain disidentification and eventual domain abandonment. Stereotype threat is 1 explanation why African Americans and Hispanic/Latino(a)s "leak" from each juncture of the academic scientific pipeline in disproportionately greater numbers than their White and Asian counterparts. Using structural equation modeling, we tested the stereotype threat-disidentification hypothesis across 3 academic years with a national longitudinal panel of undergraduate minority science students. Experience of stereotype threat was associated with scientific disidentification, which in turn predicted a significant decline in the intention to pursue a scientific career. Race/ethnicity moderated this effect, whereby the effect was evident for Hispanic/Latino(a) students but not for all African American students. We discuss findings in terms of understanding chronic stereotype threat.

  2. Chronic pelvic floor dysfunction.

    Science.gov (United States)

    Hartmann, Dee; Sarton, Julie

    2014-10-01

    The successful treatment of women with vestibulodynia and its associated chronic pelvic floor dysfunctions requires interventions that address a broad field of possible pain contributors. Pelvic floor muscle hypertonicity was implicated in the mid-1990s as a trigger of major chronic vulvar pain. Painful bladder syndrome, irritable bowel syndrome, fibromyalgia, and temporomandibular jaw disorder are known common comorbidities that can cause a host of associated muscular, visceral, bony, and fascial dysfunctions. It appears that normalizing all of those disorders plays a pivotal role in reducing complaints of chronic vulvar pain and sexual dysfunction. Though the studies have yet to prove a specific protocol, physical therapists trained in pelvic dysfunction are reporting success with restoring tissue normalcy and reducing vulvar and sexual pain. A review of pelvic anatomy and common findings are presented along with suggested physical therapy management. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Omalizumab for chronic urticaria

    DEFF Research Database (Denmark)

    Ivyanskiy, Ilya; Sand, Carsten; Thomsen, Simon Francis

    2012-01-01

    Omalizumab is a recombinant humanized monoclonal antibody that blocks the high-affinity Fc receptor of IgE. Omalizumab has been approved for the treatment of moderate to severe asthma; however, there is currently more and more data showing promising results in the management also of chronic...... urticaria. We present a case series of 19 patients with chronic urticaria treated in a university department with omalizumab and give an overview of the existing literature comprising an additional 59 cases as well as a total of 139 patients enrolled in two randomized controlled trials comparing omalizumab...... with placebo. The collective evidence points to omalizumab as a safe and effective treatment option for patients with chronic urticaria who do not sufficiently respond to standard therapy as recommended by existing guidelines....

  4. Chronic hypersensitivity pneumonitis

    Directory of Open Access Journals (Sweden)

    Pereira CA

    2016-09-01

    Full Text Available Carlos AC Pereira,1 Andréa Gimenez,2 Lilian Kuranishi,2 Karin Storrer 2 1Interstitial Lung Diseases Program, 2Pulmonology Postgraduate, Federal University of São Paulo, São Paulo, Brazil Abstract: Hypersensitivity pneumonitis (HSP is a common interstitial lung disease resulting from inhalation of a large variety of antigens by susceptible individuals. The disease is best classified as acute and chronic. Chronic HSP can be fibrosing or not. Fibrotic HSP has a large differential diagnosis and has a worse prognosis. The most common etiologies for HSP are reviewed. Diagnostic criteria are proposed for both chronic forms based on exposure, lung auscultation, lung function tests, HRCT findings, bronchoalveolar lavage, and biopsies. Treatment options are limited, but lung transplantation results in greater survival in comparison to idiopathic pulmonary fibrosis. Randomized trials with new antifibrotic agents are necessary. Keywords: interstitial lung diseases, extrinsic allergic alveolitis, diffuse lung disease, lung immune response, HRCT, farmers lung

  5. Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases.

    Science.gov (United States)

    Cardoso, Elsa Maria; Reis, Cátia; Manzanares-Céspedes, Maria Cristina

    2018-01-01

    Periodontal diseases, such as chronic periodontitis, share common inflammatory risk factors with other systemic and chronic inflammatory disorders. Mucosal tissues, such as oral epithelia, are exposed to environmental stressors, such as tobacco and oral bacteria, that might be involved in promoting a systemic inflammatory state. Conversely, chronic disorders can also affect oral health. This review will summarize recent evidence for the interrelationship between chronic periodontitis and other prevalent chronic diseases such as cardiovascular diseases, diabetes, cancer and chronic respiratory diseases. The association with pregnancy is also included due to possible obstetric complications. We will focus on inflammatory cytokines such as TNF-alpha, IL-1, and IL-6, because they have been shown to be increased in patients with chronic periodontitis, in patients with chronic systemic diseases, and in patients with both chronic periodontitis and other chronic diseases. Therefore, an imbalance towards a proinflammatory immune response could underline a bidirectional link between chronic periodontitis and other chronic diseases. Finally, we highlight that a close coordination between dental and other health professionals could promote oral health and prevent or ameliorate other chronic diseases.

  6. Chronic Obstructive Pulmonary Disease (COPD) Includes: Chronic Bronchitis and Emphysema

    Science.gov (United States)

    ... Submit Button NCHS Home Chronic Obstructive Pulmonary Disease (COPD) Includes: Chronic Bronchitis and Emphysema Recommend on Facebook ... Percent of visits to office-based physicians with COPD indicated on the medical record: 3.2% Source: ...

  7. A first-principles study of cementite (Fe{sub 3}C) and its alloyed counterparts: Elastic constants, elastic anisotropies, and isotropic elastic moduli

    Energy Technology Data Exchange (ETDEWEB)

    Ghosh, G., E-mail: g-ghosh@northwestern.edu [Department of Materials Science and Engineering, Robert R. McCormick School of Engineering and Applied Science, Northwestern University, 2220 Campus Drive, Evanston, IL 60208-3108 (United States)

    2015-08-15

    A comprehensive computational study of elastic properties of cementite (Fe{sub 3}C) and its alloyed counterparts (M{sub 3}C (M = Al, Co, Cr, Cu, Fe, Hf, Mn, Mo, Nb, Ni, Si, Ta, Ti, V, W, Zr, Cr{sub 2}FeC and CrFe{sub 2}C) having the crystal structure of Fe{sub 3}C is carried out employing electronic density-functional theory (DFT), all-electron PAW pseudopotentials and the generalized gradient approximation for the exchange-correlation energy (GGA). Specifically, as a part of our systematic study of cohesive properties of solids and in the spirit of materials genome, following properties are calculated: (i) single-crystal elastic constants, C{sub ij}, of above M{sub 3}Cs; (ii) anisotropies of bulk, Young’s and shear moduli, and Poisson’s ratio based on calculated C{sub ij}s, demonstrating their extreme anisotropies; (iii) isotropic (polycrystalline) elastic moduli (bulk, shear, Young’s moduli and Poisson’s ratio) of M{sub 3}Cs by homogenization of calculated C{sub ij}s; and (iv) acoustic Debye temperature, θ{sub D}, of M{sub 3}Cs based on calculated C{sub ij}s. We provide a critical appraisal of available data of polycrystalline elastic properties of alloyed cementite. Calculated single crystal properties may be incorporated in anisotropic constitutive models to develop and test microstructure-processing-property-performance links in multi-phase materials where cementite is a constituent phase.

  8. The Electromagnetic Counterpart of the Binary Neutron Star Merger LIGO/Virgo GW170817. III. Optical and UV Spectra of a Blue Kilonova from Fast Polar Ejecta

    Energy Technology Data Exchange (ETDEWEB)

    Nicholl, M.; Berger, E.; Kasen, D.; Metzger, B. D.; Elias, J.; Briceño, C.; Alexander, K. D.; Blanchard, P. K.; Chornock, R.; Cowperthwaite, P. S.; Eftekhari, T.; Fong, W.; Margutti, R.; Villar, V. A.; Williams, P. K. G.; Brown, W.; Annis, J.; Bahramian, A.; Brout, D.; Brown, D. A.; Chen, H. -Y.; Clemens, J. C.; Dennihy, E.; Dunlap, B.; Holz, D. E.; Marchesini, E.; Massaro, F.; Moskowitz, N.; Pelisoli, I.; Rest, A.; Ricci, F.; Sako, M.; Soares-Santos, M.; Strader, J.

    2017-10-16

    We present optical and ultraviolet spectra of the first electromagnetic counterpart to a gravitational wave (GW) source, the binary neutron star merger GW170817. Spectra were obtained nightly between 1.5 and 9.5 days post-merger, using the SOAR and Magellan telescopes; the UV spectrum was obtained with the \\textit{Hubble Space Telescope} at 5.5 days. Our data reveal a rapidly-fading blue component ($T\\approx5500$ K at 1.5 days) that quickly reddens; spectra later than $\\gtrsim 4.5$ days peak beyond the optical regime. The spectra are mostly featureless, although we identify a possible weak emission line at $\\sim 7900$ \\AA\\ at $t\\lesssim 4.5$ days. The colours, rapid evolution and featureless spectrum are consistent with a "blue" kilonova from polar ejecta comprised mainly of light $r$-process nuclei with atomic mass number $A\\lesssim 140$. This indicates a sight-line within $\\theta_{\\rm obs}\\lesssim 45^{\\circ}$ of the orbital axis. Comparison to models suggests $\\sim0.03$ M$_\\odot$ of blue ejecta, with a velocity of $\\sim 0.3c$. The required lanthanide fraction is $\\sim 10^{-4}$, but this drops to $<10^{-5}$ in the outermost ejecta. The large velocities point to a dynamical origin, rather than a disk wind, for this blue component, suggesting that both binary constituents are neutron stars (as opposed to a binary consisting of a neutron star and a black hole). For dynamical ejecta, the high mass favors a small neutron star radius of $\\lesssim 12$ km. This mass also supports the idea that neutron star mergers are a major contributor to $r$-process nucleosynthesis.

  9. Characterization of canine osteosarcoma by array comparative genomic hybridization and RT-qPCR: signatures of genomic imbalance in canine osteosarcoma parallel the human counterpart.

    Science.gov (United States)

    Angstadt, Andrea Y; Motsinger-Reif, Alison; Thomas, Rachael; Kisseberth, William C; Guillermo Couto, C; Duval, Dawn L; Nielsen, Dahlia M; Modiano, Jaime F; Breen, Matthew

    2011-11-01

    Osteosarcoma (OS) is the most commonly diagnosed malignant bone tumor in humans and dogs, characterized in both species by extremely complex karyotypes exhibiting high frequencies of genomic imbalance. Evaluation of genomic signatures in human OS using array comparative genomic hybridization (aCGH) has assisted in uncovering genetic mechanisms that result in disease phenotype. Previous low-resolution (10-20 Mb) aCGH analysis of canine OS identified a wide range of recurrent DNA copy number aberrations, indicating extensive genomic instability. In this study, we profiled 123 canine OS tumors by 1 Mb-resolution aCGH to generate a dataset for direct comparison with current data for human OS, concluding that several high frequency aberrations in canine and human OS are orthologous. To ensure complete coverage of gene annotation, we identified the human refseq genes that map to these orthologous aberrant dog regions and found several candidate genes warranting evaluation for OS involvement. Specifically, subsequenct FISH and qRT-PCR analysis of RUNX2, TUSC3, and PTEN indicated that expression levels correlated with genomic copy number status, showcasing RUNX2 as an OS associated gene and TUSC3 as a possible tumor suppressor candidate. Together these data demonstrate the ability of genomic comparative oncology to identify genetic abberations which may be important for OS progression. Large scale screening of genomic imbalance in canine OS further validates the use of the dog as a suitable model for human cancers, supporting the idea that dysregulation discovered in canine cancers will provide an avenue for complementary study in human counterparts. Copyright © 2011 Wiley-Liss, Inc.

  10. Identification of Cis-Acting Elements on Positive-Strand Subgenomic mRNA Required for the Synthesis of Negative-Strand Counterpart in Bovine Coronavirus

    Directory of Open Access Journals (Sweden)

    Po-Yuan Yeh

    2014-07-01

    Full Text Available It has been demonstrated that, in addition to genomic RNA, sgmRNA is able to serve as a template for the synthesis of the negative-strand [(−-strand] complement. However, the cis-acting elements on the positive-strand [(+-strand] sgmRNA required for (−-strand sgmRNA synthesis have not yet been systematically identified. In this study, we employed real-time quantitative reverse transcription polymerase chain reaction to analyze the cis-acting elements on bovine coronavirus (BCoV sgmRNA 7 required for the synthesis of its (−-strand counterpart by deletion mutagenesis. The major findings are as follows. (1 Deletion of the 5'-terminal leader sequence on sgmRNA 7 decreased the synthesis of the (−-strand sgmRNA complement. (2 Deletions of the 3' untranslated region (UTR bulged stem-loop showed no effect on (−-strand sgmRNA synthesis; however, deletion of the 3' UTR pseudoknot decreased the yield of (−-strand sgmRNA. (3 Nucleotides positioned from −15 to −34 of the sgmRNA 7 3'-terminal region are required for efficient (−-strand sgmRNA synthesis. (4 Nucleotide species at the 3'-most position (−1 of sgmRNA 7 is correlated to the efficiency of (−-strand sgmRNA synthesis. These results together suggest, in principle, that the 5'- and 3'-terminal sequences on sgmRNA 7 harbor cis-acting elements are critical for efficient (−-strand sgmRNA synthesis in BCoV.

  11. The Chronic Responsibility

    DEFF Research Database (Denmark)

    Ravn, Iben M; Frederiksen, Kirsten; Beedholm, Kirsten

    2016-01-01

    behavior to be the main factors influencing susceptibility to chronic diseases. We argue that this discursive construction naturalizes a division between people who can actively manage responsible self-care and those who cannot. Such discourses may serve the interests of those patients who are already...

  12. Chronic fatigue syndrome.

    NARCIS (Netherlands)

    Prins, J.B.; Meer, J.W.M. van der; Bleijenberg, G.

    2006-01-01

    During the past two decades, there has been heated debate about chronic fatigue syndrome (CFS) among researchers, practitioners, and patients. Few illnesses have been discussed so extensively. The existence of the disorder has been questioned, its underlying pathophysiology debated, and an effective

  13. Omalizumab for Chronic Urticaria:

    DEFF Research Database (Denmark)

    Ghazanfar, Misbah Nasheela; Thomsen, Simon Francis

    2017-01-01

    Purpose of Review The purpose of this study was to review real-life studies on effectiveness and safety of omalizumab in chronic urticaria (CU). Recent Findings CU is an itching skin disease characterized by wheals, angioedema, or both (present >6 weeks). Omalizumab is a humanized anti...

  14. EBV CHRONIC INFECTIONS

    Directory of Open Access Journals (Sweden)

    Eligio Pizzigallo

    2010-08-01

    Full Text Available The infection from Epstein-Barr virus (EBV or virus of infectious mononucleosis, together with other herpesviruses’ infections, represents a prototype of persistent viral infections characterized by the property of the latency. Although the reactivations of the latent infection are associated with the resumption of the viral replication and eventually with the “shedding”, it is still not clear if this virus can determine chronic infectious diseases, more or less evolutive. These diseases could include some pathological conditions actually defined as “idiopathic”and characterized by the “viral persistence” as the more credible pathogenetic factor. Among the so-called idiopathic syndromes, the “chronic fatigue syndrome” (CFS aroused a great interest around the eighties of the last century when, just for its relationship with EBV, it was called “chronic mononucleosis” or “chronic EBV infection”. Today CFS, as defined in 1994 by the CDC of Atlanta (USA, really represents a multifactorial syndrome characterized by a chronic course, where reactivation and remission phases alternate, and by a good prognosis. The etiopathogenetic role of EBV is demonstrated only in a well-examined subgroup of patients, while in most of the remaining cases this role should be played by other infectious agents - able to remain in a latent or persistent way in the host – or even by not infectious agents (toxic, neuroendocrine, methabolic, etc.. However, the pathogenetic substrate of the different etiologic forms seems to be the same, much probably represented by the oxidative damage due to the release of pro-inflammatory cytokines as a response to the triggering event (infectious or not infectious. Anyway, recently the scientists turned their’s attention to the genetic predisposition of the subjects affected by the syndrome, so that in the last years the genetic studies, together with those of molecular biology, received a great impulse

  15. Omalizumab for chronic urticaria

    DEFF Research Database (Denmark)

    Ivyanskiy, Ilya; Sand, Carsten; Thomsen, Simon Francis

    2012-01-01

    Omalizumab is a recombinant humanized monoclonal antibody that blocks the high-affinity Fc receptor of IgE. Omalizumab has been approved for the treatment of moderate to severe asthma; however, there is currently more and more data showing promising results in the management also of chronic urtic...... with placebo. The collective evidence points to omalizumab as a safe and effective treatment option for patients with chronic urticaria who do not sufficiently respond to standard therapy as recommended by existing guidelines.......Omalizumab is a recombinant humanized monoclonal antibody that blocks the high-affinity Fc receptor of IgE. Omalizumab has been approved for the treatment of moderate to severe asthma; however, there is currently more and more data showing promising results in the management also of chronic...... urticaria. We present a case series of 19 patients with chronic urticaria treated in a university department with omalizumab and give an overview of the existing literature comprising an additional 59 cases as well as a total of 139 patients enrolled in two randomized controlled trials comparing omalizumab...

  16. Chronic granulomatous disease

    NARCIS (Netherlands)

    Roos, Dirk

    2016-01-01

    Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by recurrent, life-threatening bacterial and fungal infections of the skin, the airways, the lymph nodes, the liver, the brain and the bones. Frequently found pathogens are Staphylococcus aureus, Aspergillus species,

  17. Employees with Chronic Pain

    Science.gov (United States)

    ... Fatigue/Weakness: Reduce or eliminate physical exertion and workplace stress Schedule periodic rest breaks away from the workstation ... To Implement the Equal Employment Provisions of the Americans With Disabilities Act, as ... Institute of Neurological Disorders and Stroke. (2011). NINDS chronic ...

  18. Chronic, unexplained pain

    NARCIS (Netherlands)

    Snijders, T.J.

    2012-01-01

    Chronic, unexplained pain (CUP) is a common clinical problem. The core symptom in this heterogeneous group of patients is pain for which no medical explanation is found. Patients also have many other characteristics (symptoms and psychosocial features) in common. Pathophysiologically, increased

  19. Diagnosing chronic rhinosinusitis

    DEFF Research Database (Denmark)

    Lange, B; Thilsing, T; Baelum, J

    2013-01-01

    The European Position Paper on Rhinosinusitis and Nasal Polyps (EP3OS) incorporates symptomatic and endo- scopic criteria in the clinical diagnosis of chronic rhinosinusitis (CRS), while in epidemiological studies the definition is based on symptoms only. The aim of this study was to evaluate...

  20. Chronicity and control

    DEFF Research Database (Denmark)

    Whyte, Susan Reynolds

    2012-01-01

    over the years. It suggests a pragmatic analysis that places people's perceptions and practices within a field of possibilities shaped by policy, health care systems, and life conditions. In this field, the dimensions of chronicity and control are the distinctive analytical issues. They lead...

  1. Chronic toxicology of cannabis.

    Science.gov (United States)

    Reece, Albert Stuart

    2009-07-01

    Cannabis is the most widely used illicit drug worldwide. As societies reconsider the legal status of cannabis, policy makers and clinicians require sound knowledge of the acute and chronic effects of cannabis. This review focuses on the latter. A systematic review of Medline, PubMed, PsychInfo, and Google Scholar using the search terms "cannabis," "marijuana," "marihuana," "toxicity," "complications," and "mechanisms" identified 5,198 papers. This list was screened by hand, and papers describing mechanisms and those published in more recent years were chosen preferentially for inclusion in this review. There is evidence of psychiatric, respiratory, cardiovascular, and bone toxicity associated with chronic cannabis use. Cannabis has now been implicated in the etiology of many major long-term psychiatric conditions including depression, anxiety, psychosis, bipolar disorder, and an amotivational state. Respiratory conditions linked with cannabis include reduced lung density, lung cysts, and chronic bronchitis. Cannabis has been linked in a dose-dependent manner with elevated rates of myocardial infarction and cardiac arrythmias. It is known to affect bone metabolism and also has teratogenic effects on the developing brain following perinatal exposure. Cannabis has been linked to cancers at eight sites, including children after in utero maternal exposure, and multiple molecular pathways to oncogenesis exist. Chronic cannabis use is associated with psychiatric, respiratory, cardiovascular, and bone effects. It also has oncogenic, teratogenic, and mutagenic effects all of which depend upon dose and duration of use.

  2. Chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    V K Vijayan

    2013-01-01

    Full Text Available The global prevalence of physiologically defined chronic obstructive pulmonary disease (COPD in adults aged >40 yr is approximately 9-10 per cent. Recently, the Indian Study on Epidemiology of Asthma, Respiratory Symptoms and Chronic Bronchitis in Adults had shown that the overall prevalence of chronic bronchitis in adults >35 yr is 3.49 per cent. The development of COPD is multifactorial and the risk factors of COPD include genetic and environmental factors. Pathological changes in COPD are observed in central airways, small airways and alveolar space. The proposed pathogenesis of COPD includes proteinase-antiproteinase hypothesis, immunological mechanisms, oxidant-antioxidant balance, systemic inflammation, apoptosis and ineffective repair. Airflow limitation in COPD is defined as a postbronchodilator FEV1 (forced expiratory volume in 1 sec to FVC (forced vital capacity ratio <0.70. COPD is characterized by an accelerated decline in FEV1. Co morbidities associated with COPD are cardiovascular disorders (coronary artery disease and chronic heart failure, hypertension, metabolic diseases (diabetes mellitus, metabolic syndrome and obesity, bone disease (osteoporosis and osteopenia, stroke, lung cancer, cachexia, skeletal muscle weakness, anaemia, depression and cognitive decline. The assessment of COPD is required to determine the severity of the disease, its impact on the health status and the risk of future events (e.g., exacerbations, hospital admissions or death and this is essential to guide therapy. COPD is treated with inhaled bronchodilators, inhaled corticosteroids, oral theophylline and oral phosphodiesterase-4 inhibitor. Non pharmacological treatment of COPD includes smoking cessation, pulmonary rehabilitation and nutritional support. Lung volume reduction surgery and lung transplantation are advised in selected severe patients. Global strategy for the diagnosis, management and prevention of Chronic Obstructive Pulmonary Disease

  3. Screening for Chronic Kidney Disease

    Science.gov (United States)

    Understanding Task Force Recommendations Screening for Chronic Kidney Disease The U.S. Preventive Services Task Force (Task Force) has issued a final recommendation on Screening for Chronic Kidney Disease (CKD) . This recommendation ...

  4. Acute vs. chronic conditions (image)

    Science.gov (United States)

    ... describe anything from a broken bone to an asthma attack. A chronic condition, by contrast is a long- ... a broken bone, an acute condition. An acute asthma attack occurs in the midst of the chronic disease ...

  5. Defining and Measuring Chronic Conditions

    Centers for Disease Control (CDC) Podcasts

    2013-05-20

    This podcast is an interview with Dr. Anand Parekh, U.S. Department of Health and Human Services Deputy Assistant Secretary for Health, and Dr. Samuel Posner, Preventing Chronic Disease Editor in Chief, about the definition and burden of multiple chronic conditions in the United States.  Created: 5/20/2013 by Preventing Chronic Disease (PCD), National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 5/20/2013.

  6. Anemia in Chronic Kidney Disease

    Science.gov (United States)

    ... artérielle Heart Disease Mineral & Bone Disorder Anemia in Chronic Kidney Disease What is anemia? Anemia is a condition in ... as they should. How is anemia related to chronic kidney disease? Anemia commonly occurs in people with chronic kidney ...

  7. Vacuum therapy for chronic wounds

    Directory of Open Access Journals (Sweden)

    Ekaterina Leonidovna Zaytseva

    2012-09-01

    Full Text Available Chronic wound in patients with diabetes mellitus (DM is one of the most urgent problems of modern diabetology and surgery. Numberof patients suffering from different types of chronic wounds follows increase in DM incidence. Vacuum therapy is a novel perspectivemethod of topical treatment for non-healing chronic wounds of various etiology. Current review addresses experimental and clinicalevidence for this method.

  8. Brucella-Salmonella lipopolysaccharide chimeras are less permeable to hydrophobic probes and more sensitive to cationic peptides and EDTA than are their native Brucella sp. counterparts.

    Science.gov (United States)

    Freer, E; Moreno, E; Moriyón, I; Pizarro-Cerdá, J; Weintraub, A; Gorvel, J P

    1996-01-01

    A rough (R) Brucella abortus 45/20 mutant was more sensitive to the bactericidal activity of polymyxin B and lactoferricin B than was its smooth (S) counterpart but considerably more resistant than Salmonella montevideo. The outer membrane (OM) and isolated lipopolysaccharide (LPS) of S. montevideo showed a higher affinity for these cationic peptides than did the corresponding B. abortus OM and LPS. We took advantage of the moderate sensitivity of R B. abortus to cationic peptides to construct live R B. abortus-S-LPS chimeras to test the activities of polymyxin B, lactoferricin B, and EDTA. Homogeneous and abundant peripheral distribution of the heterologous S-LPS was observed on the surface of the chimeras, and this coating had no effect on the viability or morphology of the cells. When the heterologous LPS corresponded to the less sensitive bacterium S B. abortus S19, the chimeras were more resistant to cationic peptides; in contrast, when the S-LPS was from the more sensitive bacterium S. montevideo, the chimeras were more susceptible to the action of peptides and EDTA. A direct correlation between the amount of heterologous S-LPS on the surface of chimeric Brucella cells and peptide sensitivity was observed. Whereas the damage produced by polymyxin B in S. montevideo and B. abortus-S. montevideo S-LPS chimeras was manifested mainly as OM blebbing and inner membrane rolling, lactoferricin B caused inner membrane detachment, vacuolization, and the formation of internal electron-dense granules in these cells. Native S and R B. abortus strains were permeable to the hydrophobic probe N-phenyl-1-naphthylamine (NPN). In contrast, only reduced amounts of NPN partitioned into the OMs of the S. montevideo and B. abortus-S. montevideo S-LPS chimeras. Following peptide exposure, accelerated NPN uptake similar to that observed for S. montevideo was detected for the B. abortus-S. montevideo LPS chimeras. The partition of NPN into native or EDTA-, polymyxin B-, or

  9. Brucella-Salmonella lipopolysaccharide chimeras are less permeable to hydrophobic probes and more sensitive to cationic peptides and EDTA than are their native Brucella sp. counterparts.

    Science.gov (United States)

    Freer, E; Moreno, E; Moriyón, I; Pizarro-Cerdá, J; Weintraub, A; Gorvel, J P

    1996-10-01

    A rough (R) Brucella abortus 45/20 mutant was more sensitive to the bactericidal activity of polymyxin B and lactoferricin B than was its smooth (S) counterpart but considerably more resistant than Salmonella montevideo. The outer membrane (OM) and isolated lipopolysaccharide (LPS) of S. montevideo showed a higher affinity for these cationic peptides than did the corresponding B. abortus OM and LPS. We took advantage of the moderate sensitivity of R B. abortus to cationic peptides to construct live R B. abortus-S-LPS chimeras to test the activities of polymyxin B, lactoferricin B, and EDTA. Homogeneous and abundant peripheral distribution of the heterologous S-LPS was observed on the surface of the chimeras, and this coating had no effect on the viability or morphology of the cells. When the heterologous LPS corresponded to the less sensitive bacterium S B. abortus S19, the chimeras were more resistant to cationic peptides; in contrast, when the S-LPS was from the more sensitive bacterium S. montevideo, the chimeras were more susceptible to the action of peptides and EDTA. A direct correlation between the amount of heterologous S-LPS on the surface of chimeric Brucella cells and peptide sensitivity was observed. Whereas the damage produced by polymyxin B in S. montevideo and B. abortus-S. montevideo S-LPS chimeras was manifested mainly as OM blebbing and inner membrane rolling, lactoferricin B caused inner membrane detachment, vacuolization, and the formation of internal electron-dense granules in these cells. Native S and R B. abortus strains were permeable to the hydrophobic probe N-phenyl-1-naphthylamine (NPN). In contrast, only reduced amounts of NPN partitioned into the OMs of the S. montevideo and B. abortus-S. montevideo S-LPS chimeras. Following peptide exposure, accelerated NPN uptake similar to that observed for S. montevideo was detected for the B. abortus-S. montevideo LPS chimeras. The partition of NPN into native or EDTA-, polymyxin B-, or

  10. Disease features and outcomes in United States lupus patients of Hispanic origin and their Mestizo counterparts in Latin America: a commentary.

    Science.gov (United States)

    Ugarte-Gil, Manuel F; Pons-Estel, Guillermo J; Molineros, Julio; Wojdyla, Daniel; McGwin, Gerald; Nath, Swapan K; Pons-Estel, Bernardo A; Alarcón-Riquelme, Marta; Alarcón, Graciela S

    2016-03-01

    To evaluate disease features and outcomes in two populations with significant Amerindian ancestry. Hispanic patients (from Texas) from the Lupus in Minorities: Nature versus Nurture (LUMINA) cohort and Mestizo patients from the Grupo Latino Americano De Estudio del Lupus or Latin American Group for the Study of Lupus (GLADEL) cohort were included. Disease features and outcomes were evaluated at baseline and last visit. Admixture informative markers of Mestizo Genoma de Lupus Eritematoso Sistémico Network consortium (GENLES) patients and Hispanic LUMINA patients were compared. Univariable analyses were performed using Chi square or Student's t test as appropriate. Multivariable analyses adjusting for possible confounders were carried out using Poisson, logistic or Cox regression models as appropriate. A total of 114 LUMINA and 619 GLADEL patients were included. GLADEL patients had accrued more damage at baseline, but the opposite was the case at last visit. Being from LUMINA was a risk factor for damage accrual, even after adjusting for possible confounders [relative risk (RR) 1.33, 95% CI 1.12, 1.58]. Also, LUMINA patients have a higher risk of mortality than GLADEL patients [hazard ratio (HR) 2.37, 95% CI 1.10, 5.15], having 5-year survival of 85.6% and 94.5%, respectively. In addition, 79 LUMINA patients and 744 Mestizo GENLES patients were evaluated in order to compare genetic ancestry between the two groups; GENLES patients had a higher proportion of European ancestry (48.5% vs 43.3%, P = 0.003) and a lower proportion of Asian ancestry (3.7% vs 4.9%, P = 0.048), but the proportions of Amerindian and African ancestry were comparable in both. USA Hispanic patients seemed to have a poorer prognosis than their counterparts from Latin America, despite having a comparable genetic background. Socioeconomic factors may account for these observations. © The Author 2015. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights

  11. Chronic progressive multiple sclerosis

    International Nuclear Information System (INIS)

    Buffoli, A.; Micheletti, E.; Capra, R.; Mattioli, F.; Marciano', N.

    1991-01-01

    A long-lasting immunological suppression action seems to be produced by total lymphoid irradiation; some authors emphasize the favorable effect of this treatment on chronic progressive multiple sclerosis. In order to evaluate the actual role of TLI, 6 patients affected with chronic progressive multiple sclerosis were submitted to TLI with shaped and personalized fields at the Istituto del Radio, University of Brescia, Italy. The total dose delivered was 19.8 Gy in 4 weeks, 1.8 Gy/day, 5d/w; a week elapsed between the first and the second irradiation course. Disability according to Kurtzke scale was evaluated, together with blood lymphocyte count and irradiation side-effects, over a mean follow-up period of 20.8 months (range: 13-24). Our findings indicate that: a) disease progression was not markedly reduced by TLI; b) steroid hormones responsivity was restored after irradiation, and c) side-effects were mild and tolerable

  12. Chronic intestinal pseudoobstruction syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Yeon, Kyung Mo; Seo, Jeong Kee; Lee, Yong Seok [Seoul National University Children' s Hospital, Seoul (Korea, Republic of)

    1992-03-15

    Chronic intestinal pseudoobstruction syndrome is a rare clinical condition in which impaired intestinal peristalsis causes recurrent symptoms of bowel obstruction in the absence of a mechanical occlusion. This syndrome may involve variable segments of small or large bowel, and may be associated with urinary bladder retention. This study included 6 children(3 boys and 3 girls) of chronic intestinal obstruction. Four were symptomatic at birth and two were of the ages of one month and one year. All had abdominal distension and deflection difficulty. Five had urinary bladder distension. Despite parenteral nutrition and surgical intervention(ileostomy or colostomy), bowel obstruction persisted and four patients expired from sepses within one year. All had gaseous distension of small and large bowel on abdominal films. In small bowel series, consistent findings were variable degree of dilatation, decreased peristalsis(prolonged transit time) and microcolon or microrectum. This disease entity must be differentiated from congenital megacolon, ileal atresia and megacystis syndrome.

  13. Bilateral chronic subdural hematoma

    DEFF Research Database (Denmark)

    Andersen-Ranberg, Nina Christine; Rom Poulsen, Frantz; Bergholt, Bo

    2017-01-01

    OBJECTIVE Bilateral chronic subdural hematoma (bCSDH) is a common neurosurgical condition frequently associated with the need for retreatment. The reason for the high rate of retreatment has not been thoroughly investigated. Thus, the authors focused on determining which independent predictors...... are associated with the retreatment of bCSDH with a focus on surgical laterality. METHODS In a national database of CSDHs (Danish Chronic Subdural Hematoma Study) the authors retrospectively identified all bCSDHs treated in the 4 Danish neurosurgical departments over the 3-year period from 2010 to 2012...... that a separated hematoma density and the absence of postoperative drainage were independent predictors of retreatment. CONCLUSIONS In bCSDHs bilateral surgical intervention significantly lowers the risk of retreatment compared with unilateral intervention and should be considered when choosing a surgical...

  14. Chronic Actinic Dermatitis

    Directory of Open Access Journals (Sweden)

    Bengü Çevirgen Cemil

    2017-06-01

    Full Text Available Chronic actinic dermatitis (CAD is characterized by persistent eczema-like lesions, mainly on sun-exposed sites, induced by ultraviolet B, sometimes ultraviolet A, and occasionally visible light. CAD is a rare photodermatitis. It is often associated with contact allergens including airborne allergens such as fragrances, plant antigens and topical medications. A 62 year old farmer is applied with eczematous lesions restricted to sun-exposed areas. Clinical findings and histopathologic features were consistent with the diagnosis of chronic actinic dermatitis. The patient also had contact allergy to multiple allergens. We present this case to emphasize the significance of patch test on CAD treatment and the success of topical tacrolimus and azathioprine.

  15. Chronic spinal subdural hematoma

    International Nuclear Information System (INIS)

    Hagen, T.; Lensch, T.

    2008-01-01

    Compared with spinal epidural hematomas, spinal subdural hematomas are rare; chronic forms are even more uncommon. These hematomas are associated not only with lumbar puncture and spinal trauma, but also with coagulopathies, vascular malformations and tumors. Compression of the spinal cord and the cauda equina means that the patients develop increasing back or radicular pain, followed by paraparesis and bladder and bowel paralysis, so that in most cases surgical decompression is carried out. On magnetic resonance imaging these hematomas present as thoracic or lumbar subdural masses, their signal intensity varying with the age of the hematoma. We report the clinical course and the findings revealed by imaging that led to the diagnosis in three cases of chronic spinal subdural hematoma. (orig.) [de

  16. The burden of chronic pain

    DEFF Research Database (Denmark)

    Kurita, Geana Paula; Sjøgren, Per; Juel, Knud

    2012-01-01

    sample consisted of 25,000 individuals (≥16 years old) living in Denmark. In all, 60.7% completed a mailed or online questionnaire. Associations were examined with multiple logistic regression analysis. The study population consisted of 14,925 individuals in whom a high prevalence of chronic pain (26......Chronic pain is currently considered a public health problem with high costs to the individual and society. To improve prevention and treatment of chronic pain, epidemiologic studies are mandatory for assessing chronic pain. The aims of this study were to estimate the prevalence of chronic pain...

  17. Chronic whiplash pain.

    Science.gov (United States)

    Seroussi, Richard; Singh, Virtaj; Fry, Adrielle

    2015-05-01

    Although most patients recover from acute whiplash injuries, those with chronic whiplash syndrome develop signs of central nervous system (CNS) amplification of pain and have a poor prognosis. In this context, specific pain generators from acute whiplash have been identified through clinical, biomechanical, and animal studies. This article gives a clinical perspective on current understanding of these pain generators, including the phenomenon of CNS sensitization. Copyright © 2015 Elsevier Inc. All rights reserved.

  18. Chronic Abdominal Wall Pain.

    Science.gov (United States)

    Koop, Herbert; Koprdova, Simona; Schürmann, Christine

    2016-01-29

    Chronic abdominal wall pain is a poorly recognized clinical problem despite being an important element in the differential diagnosis of abdominal pain. This review is based on pertinent articles that were retrieved by a selective search in PubMed and EMBASE employing the terms "abdominal wall pain" and "cutaneous nerve entrapment syndrome," as well as on the authors' clinical experience. In 2% to 3% of patients with chronic abdominal pain, the pain arises from the abdominal wall; in patients with previously diagnosed chronic abdominal pain who have no demonstrable pathological abnormality, this likelihood can rise as high as 30% . There have only been a small number of clinical trials of treatment for this condition. The diagnosis is made on clinical grounds, with the aid of Carnett's test. The characteristic clinical feature is strictly localized pain in the anterior abdominal wall, which is often mischaracterized as a "functional" complaint. In one study, injection of local anesthesia combined with steroids into the painful area was found to relieve pain for 4 weeks in 95% of patients. The injection of lidocaine alone brought about improvement in 83-91% of patients. Long-term pain relief ensued after a single lidocaine injection in 20-30% of patients, after repeated injections in 40-50% , and after combined lidocaine and steroid injections in up to 80% . Pain that persists despite these treatments can be treated with surgery (neurectomy). Chronic abdominal wall pain is easily diagnosed on physical examination and can often be rapidly treated. Any physician treating patients with abdominal pain should be aware of this condition. Further comparative treatment trials will be needed before a validated treatment algorithm can be established.

  19. EBV CHRONIC INFECTIONS

    Directory of Open Access Journals (Sweden)

    Delia Racciatti

    2010-02-01

    Full Text Available

    The infection from Epstein-Barr virus (EBV or virus of infectious mononucleosis, together with other herpesviruses’ infections, represents a prototype of persistent viral infections characterized by the property of the latency. Although the reactivations of the latent infection are associated with the resumption of the viral replication and eventually with the “shedding”, it is still not clear if this virus can determine chronic infectious diseases, more or less evolutive. These diseases could include some pathological conditions actually defined as “idiopathic”and characterized by the “viral persistence” as the more credible pathogenetic factor. Among the so-called idiopathic syndromes, the “chronic fatigue syndrome” (CFS aroused a great interest around the eighties of the last century when, just for its relationship with EBV, it was called “chronic mononucleosis” or “chronic EBV infection”.

    Today CFS, as defined in 1994 by the CDC of Atlanta (USA, really represents a multifactorial syndrome characterized by a chronic course, where reactivation and remission phases alternate, and by a good prognosis

  20. Clinicoroentgenological control in chronic pneumonia

    International Nuclear Information System (INIS)

    Mamilyaev, R.M.

    1984-01-01

    A comprehensive clinicoroentgenological study was used to examine 494 patients with chronic pneumonia. Morphological and functional changes observed in the pulmonary pare and functional changes observed in the pulmonary parenchyma and bronchial tree were studied. Types of pneumosclerosis, tigns of exacerbation of chronic pneumonia and abscess formation, morphological and functional disorders of bronchial penetrability in the pneumonic zone were described. Three forms of chronic pneumonia: bronchial, bronchiectatic and abscessing are signled out. The bronchial form is subdivided into chronic pneumonia with chronic bronchitis without deformity and wi.th deforming chronic bronchitis. In the bronchiectatic form pneumonia can be with cylindrical, saccular and cyst-like bronchiectasia. The general diagnosis of chronic pneumonia is established clinically depending on type and variants in 89-94% of cases, by X-ray and sonographic findings in all patients; types and variants of disease are most frequently defined after bronchography

  1. Chronic Alcohol Ingestion Delays T Cell Activation and Effector Function in Sepsis.

    Directory of Open Access Journals (Sweden)

    Lindsay M Margoles

    Full Text Available Sepsis is the leading cause of death in intensive care units in the US, and it is known that chronic alcohol use is associated with higher incidence of sepsis, longer ICU stays, and higher mortality from sepsis. Both sepsis and chronic alcohol use are associated with immune deficits such as decreased lymphocyte numbers, impaired innate immunity, delayed-type hypersensitivity reactions, and susceptibility to infections; however, understanding of specific pathways of interaction or synergy between these two states of immune dysregulation is lacking. This study therefore sought to elucidate mechanisms underlying the immune dysregulation observed during sepsis in the setting of chronic alcohol exposure. Using a murine model of chronic ethanol ingestion followed by sepsis induction via cecal ligation and puncture, we determined that while CD4+ and CD8+ T cells isolated from alcohol fed mice eventually expressed the same cellular activation markers (CD44, CD69, and CD43 and effector molecules (IFN-γ, TNF as their water fed counterparts, there was an overall delay in the acquisition of these phenotypes. This early lag in T cell activation was associated with significantly reduced IL-2 production at a later timepoint in both the CD4+ and CD8+ T cell compartments in alcohol sepsis, as well as with a reduced accumulation of CD8dim activated effectors. Taken together, these data suggest that delayed T cell activation may result in qualitative differences in the immune response to sepsis in the setting of chronic alcohol ingestion.

  2. Chronic Alcohol Ingestion Delays T Cell Activation and Effector Function in Sepsis.

    Science.gov (United States)

    Margoles, Lindsay M; Mittal, Rohit; Klingensmith, Nathan J; Lyons, John D; Liang, Zhe; Serbanescu, Mara A; Wagener, Maylene E; Coopersmith, Craig M; Ford, Mandy L

    2016-01-01

    Sepsis is the leading cause of death in intensive care units in the US, and it is known that chronic alcohol use is associated with higher incidence of sepsis, longer ICU stays, and higher mortality from sepsis. Both sepsis and chronic alcohol use are associated with immune deficits such as decreased lymphocyte numbers, impaired innate immunity, delayed-type hypersensitivity reactions, and susceptibility to infections; however, understanding of specific pathways of interaction or synergy between these two states of immune dysregulation is lacking. This study therefore sought to elucidate mechanisms underlying the immune dysregulation observed during sepsis in the setting of chronic alcohol exposure. Using a murine model of chronic ethanol ingestion followed by sepsis induction via cecal ligation and puncture, we determined that while CD4+ and CD8+ T cells isolated from alcohol fed mice eventually expressed the same cellular activation markers (CD44, CD69, and CD43) and effector molecules (IFN-γ, TNF) as their water fed counterparts, there was an overall delay in the acquisition of these phenotypes. This early lag in T cell activation was associated with significantly reduced IL-2 production at a later timepoint in both the CD4+ and CD8+ T cell compartments in alcohol sepsis, as well as with a reduced accumulation of CD8dim activated effectors. Taken together, these data suggest that delayed T cell activation may result in qualitative differences in the immune response to sepsis in the setting of chronic alcohol ingestion.

  3. Influence of macrocyclic chelators on the targeting properties of (68Ga-labeled synthetic affibody molecules: comparison with (111In-labeled counterparts.

    Directory of Open Access Journals (Sweden)

    Joanna Strand

    Full Text Available Affibody molecules are a class of small (7 kDa non-immunoglobulin scaffold-based affinity proteins, which have demonstrated substantial potential as probes for radionuclide molecular imaging. The use of positron emission tomography (PET would further increase the resolution and quantification accuracy of Affibody-based imaging. The rapid in vivo kinetics of Affibody molecules permit the use of the generator-produced radionuclide (68Ga (T1/2=67.6 min. Earlier studies have demonstrated that the chemical nature of chelators has a substantial influence on the biodistribution properties of Affibody molecules. To determine an optimal labeling approach, the macrocyclic chelators 1,4,7,10-tetraazacylododecane-1,4,7,10-tetraacetic acid (DOTA, 1,4,7-triazacyclononane-N,N,N-triacetic acid (NOTA and 1-(1,3-carboxypropyl-1,4,7- triazacyclononane-4,7-diacetic acid (NODAGA were conjugated to the N-terminus of the synthetic Affibody molecule ZHER2:S1 targeting HER2. Affibody molecules were labeled with (68Ga, and their binding specificity and cellular processing were evaluated. The biodistribution of (68Ga-DOTA-ZHER2:S1, (68Ga-NOTA-ZHER2:S1 and (68Ga-NODAGA-ZHER2:S1, as well as that of their (111In-labeled counterparts, was evaluated in BALB/C nu/nu mice bearing HER2-expressing SKOV3 xenografts. The tumor uptake for (68Ga-DOTA-ZHER2:S1 (17.9 ± 0.7%IA/g was significantly higher than for both (68Ga-NODAGA-ZHER2:S1 (16.13 ± 0.67%IA/g and (68Ga-NOTA-ZHER2:S1 (13 ± 3%IA/g at 2 h after injection. (68Ga-NODAGA-ZHER2:S1 had the highest tumor-to-blood ratio (60 ± 10 in comparison with both (68Ga-DOTA-ZHER2:S1 (28 ± 4 and (68Ga-NOTA-ZHER2:S1 (42 ± 11. The tumor-to-liver ratio was also higher for (68Ga-NODAGA-ZHER2:S1 (7 ± 2 than the DOTA and NOTA conjugates (5.5 ± 0.6 vs.3.3 ± 0.6. The influence of chelator on the biodistribution and targeting properties was less pronounced for (68Ga than for (111In. The results of this study demonstrate that macrocyclic

  4. Chronic disease management in general practice: results from a national study.

    Science.gov (United States)

    Darker, C; Martin, C; O'Dowd, T; O'Kelly, F; O'Shea, B

    2012-04-01

    The aim of this study was to provide baseline data on chronic disease management (CDM) provision in Irish general practice (GP). The survey instrument was previously used in a study of primary care physicians in 11 countries, thus allowing international comparisons. The response rate was 72% (380/527).The majority of GPs (240/380; 63%) reported significant changes are needed in our health care system to make CDM work better. Small numbers of routine clinical audits are being performed (95/380; 25%). Irish GPs use evidence based guidelines for treatment of diabetes (267/380; 71%), asthma / COPD (279/380; 74%) and hypertension (297/380; 79%), to the same extent as international counterparts. Barriers to delivering chronic care include increased workload (379/380; 99%), lack of appropriate funding (286/380; 76%), with GPs interested in targeted payments (244/380; 68%). This study provides baseline data to assess future changes in CDM.

  5. Chronic disease management in general practice: results from a national study.

    LENUS (Irish Health Repository)

    Darker, C

    2012-04-01

    The aim of this study was to provide baseline data on chronic disease management (CDM) provision in Irish general practice (GP). The survey instrument was previously used in a study of primary care physicians in 11 countries, thus allowing international comparisons. The response rate was 72% (380\\/527).The majority of GPs (240\\/380; 63%) reported significant changes are needed in our health care system to make CDM work better. Small numbers of routine clinical audits are being performed (95\\/380; 25%). Irish GPs use evidence based guidelines for treatment of diabetes (267\\/380; 71%), asthma \\/ COPD (279\\/380; 74%) and hypertension (297\\/380; 79%), to the same extent as international counterparts. Barriers to delivering chronic care include increased workload (379\\/380; 99%), lack of appropriate funding (286\\/380; 76%), with GPs interested in targeted payments (244\\/380; 68%). This study provides baseline data to assess future changes in CDM.

  6. Motivated Shield From Chronic Noise Environment: Moderation of the Relationship Between Noise Sensitivity and Work Wellbeing by Need for Closure

    Directory of Open Access Journals (Sweden)

    Stefano Livi

    2018-05-01

    Full Text Available Several studies have underlined how chronic exposure to environmental noise may have negative effects on performance, wellbeing, and social relations. The present study (N = 90 employees of a motor factory who are chronically exposed to environmental noise investigated whether the negative effects of chronic exposure of noise-sensitive individuals to noise in the workplace may be moderated by the need for cognitive closure (i.e., an epistemic tendency to reduce uncertainty; NFCC, Kruglanski, 2004. As NFCC has been shown to enhance protection of the focal goal by reducing interference (Kossowska, 2007; Pica et al., 2013, we hypothesized that people with high NFCC should be able to manage the interference coming from environmental noise and concentrate on their tasks more than their low-NFCC counterparts. The results confirm that the negative effects of noise sensitivity on job satisfaction, state anxiety, and turnover intent were higher among low (vs. high-NFCC individuals.

  7. History of Chronic Subdural Hematoma

    Science.gov (United States)

    2015-01-01

    Trephination or trepanation is an intentional surgical procedure performed from the Stone Age. It looks like escaping a black evil from the head. This technique is still used for treatment of chronic subdural hematoma (SDH). Now, we know the origin, pathogenesis and natural history of this lesion. The author try to explore the history of trephination and modern discovery of chronic SDH. The author performed a detailed electronic search of PubMed. By the key word of chronic SDH, 2,593 articles were found without language restriction in May 2015. The author reviewed the fact and way, discovering the present knowledge on the chronic SDH. The first authentic report of chronic SDH was that of Wepfer in 1657. Chronic SDH was regarded as a stroke in 17th century. It was changed as an inflammatory disease in 19th century by Virchow, and became a traumatic lesion in 20th century. However, trauma is not necessary in many cases of chronic SDHs. The more important prerequisite is sufficient potential subdural space, degeneration of the brain. Modifying Virchow's description, chronic SDH is sometimes traumatic, but most often caused by severe degeneration of the brain. From Wepfer's first description, nearly 350 years passed to explore the origin, pathogenesis, and fate of chronic SDH. The nature of the black evil in the head of the Stone Age is uncovering by many authors riding the giant's shoulder. Chronic SDH should be categorized as a degenerative lesion instead of a traumatic lesion. PMID:27169062

  8. [Chronic appendicitis. A case report].

    Science.gov (United States)

    Montiel-Jarquín, Alvaro José; Gómez-Conde, Eduardo; Reyes-Páramo, Pedro; Romero-Briones, Carlos; Mendoza-García, Aurelio Valentín; García-Ramírez, Ulises Noel

    2008-01-01

    The term chronic appendicitis has been used to describe any type of chronic pain that originates in the appendix, with or without inflammation. This broad category can be divided more specifically into: chronic or recurrent appendicitis and appendiceal colic pain. a 41-year-old female, suffering intestinal chronic constipation, abdominal pain, nausea, hiporexia and febricula, treated with antibiotics, vermifuges, analgesics and antispasmodics, showing a slight and partial improvement. She was suffering chronic pain in lower abdomen, mostly on the right side along a year. With these symptoms, she underwent an exploratory laparotomy, that showed chronic appendicitis. Appendix had been removed. The histopathological report corresponded to chronic appendicitis. the histopathological characteristics and the clinical manifestations of the chronic appendicitis are different from those of acute appendicitis. Criteria for chronic appendicitis include: symptoms lasting longer than 4 weeks, confirmation of chronic swelling through histopathological examination, improvement of symptoms after appendectomy. The ultrasonic images, the barium enema and the computerized helicoidal tomography could be suggestive for its diagnosis.

  9. Refractory chronic cluster headache

    DEFF Research Database (Denmark)

    Mitsikostas, Dimos D; Edvinsson, Lars; Jensen, Rigmor H

    2014-01-01

    Chronic cluster headache (CCH) often resists to prophylactic pharmaceutical treatments resulting in patients' life damage. In this rare but pragmatic situation escalation to invasive management is needed but framing criteria are lacking. We aimed to reach a consensus for refractory CCH definition...... for clinical and research use. The preparation of the final consensus followed three stages. Internal between authors, a larger between all European Headache Federation members and finally an international one among all investigators that have published clinical studies on cluster headache the last five years...

  10. Chronic Pain in Neurosurgery.

    Science.gov (United States)

    Grodofsky, Samuel

    2016-09-01

    This review includes a summary of contemporary theories of pain processing and advocates a multimodal analgesia approach for providing perioperative care. A summary of various medication classes and anesthetic techniques is provided that highlights evidence emerging from neurosurgical literature. This summary covers opioid management, acetaminophen, nonsteroidal antiinflammatories, ketamine, lidocaine, dexmedetomidine, corticosteroids, gabapentin, and regional anesthesia for neurosurgery. At present, there is not enough investigation into these areas to describe best practices for treating or preventing chronic pain in neurosurgery; but providers can identify a wider range of options available to personalize perioperative care strategies. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Treatment Strategies for Chronic Cases

    Directory of Open Access Journals (Sweden)

    Susan M Lord

    2003-01-01

    Full Text Available The treatment of chronic somatic pain, including pain referred to the head, neck, shoulder girdle and upper limb from somatic structures, is addressed. Levels of evidence for the various treatments that have been prescribed for chronic whiplash associated disorders are considered. The challenge to find a treatment strategy for chronic pain after whiplash that completely relieves the condition and prevents its sequelae is reviewed.

  12. Evaluation of chronic diarrhea.

    Science.gov (United States)

    Juckett, Gregory; Trivedi, Rupal

    2011-11-15

    Chronic diarrhea, defined as a decrease in stool consistency for more than four weeks, is a common but challenging clinical scenario. It can be divided into three basic categories: watery, fatty (malabsorption), and inflammatory. Watery diarrhea may be subdivided into osmotic, secretory, and functional types. Watery diarrhea includes irritable bowel syndrome, which is the most common cause of functional diarrhea. Another example of watery diarrhea is microscopic colitis, which is a secretory diarrhea affecting older persons. Laxative-induced diarrhea is often osmotic. Malabsorptive diarrhea is characterized by excess gas, steatorrhea, or weight loss; giardiasis is a classic infectious example. Celiac disease (gluten-sensitive enteropathy) is also malabsorptive, and typically results in weight loss and iron deficiency anemia. Inflammatory diarrhea, such as ulcerative colitis or Crohn disease, is characterized by blood and pus in the stool and an elevated fecal calprotectin level. Invasive bacteria and parasites also produce inflammation. Infections caused by Clostridium difficile subsequent to antibiotic use have become increasingly common and virulent. Not all chronic diarrhea is strictly watery, malabsorptive, or inflammatory, because some categories overlap. Still, the most practical diagnostic approach is to attempt to categorize the diarrhea by type before testing and treating. This narrows the list of diagnostic possibilities and reduces unnecessary testing. Empiric therapy is justified when a specific diagnosis is strongly suspected and follow-up is available.

  13. [Pathophysiology of chronic diarrhea].

    Science.gov (United States)

    Gerok, W

    2000-10-12

    The symptom of diarrhoea is defined as an abnormally frequent discharge from the bowel (more than 3 times a day) and a semisolid or fluid consistency of the faecal matter. Diarrhoea is termed chronic when it lasts more than four weeks. Diarrhoea is the result of disturbances in enteral water and electrolyte balance. Increased intestinal motility is usually not the cause but the result of diarrhoea. Transport of water through the gut is dependent on the osmotic gradient between interstitium and gut lumen. The secretion of chloride ions by the cells of the intestinal glands plays a major role in water secretion into the gut lumen, while sodium and potassium absorption in the villous zone of the enterocytes is crucial for enteral water absorption. Enteral water and electrolyte balance is regulated by the autonomic and enteral nervous system, by gastrointestinal hormones and signal messengers of mesenchymal cells. Pathogenetically, one distinguishes between secretory and osmotic diarrhoea. Furthermore, mixed forms of both pathogenic types can occur. The various types can be differentiated clinically and by the "osmotic gap". Diarrhoea can be a symptom of various diseases. Its pathogenesis is illustrated using examples of diarrhoea in pathological bile acid absorption, bacterial infections, carbohydrate malabsorption or disaccharidase insufficiency and in chronic inflammatory bowel disease.

  14. Chronic obstructive pulmonary disease

    International Nuclear Information System (INIS)

    Karabulut, N.

    2012-01-01

    Full text: Chronic obstructive pulmonary diseases (COPD) denote progressive lung diseases characterized by airway obstruction. COPD exhibits specific morphologic changes in the lung parenchyma, central and peripheral airways and pulmonary vasculature. A person with COPD may have either emphysema or chronic bronchitis, but most have both. Some people with COPD may also have an asthma-like or reactive component. Imaging modalities play important role in the detection or exclusion of COPD, distribution and extent of disease processes. Combined inspiratory and expiratory high resolution CT allows phenotyping of COPD (emphysema predominant, airway predominant, or mixed) and quantification of severity. Magnetic resonance imaging enables functional evaluation and demonstrates ventilation defects correlating closely with pulmonary function tests. Imaging techniques are also helpful in guiding the treatment, such as bullectomy in patients with bullous emphysema, lung volume reduction surgery or endoscopic interventions in those with severe emphysema, and smoking cessation and medical treatment designed to stop lung destruction in patients with mild or moderate emphysema or bronchiectasis.

  15. Spectroscopic study of the optical counterpart to the fast X-ray transient IGR J17544-2619 based on observations at the 1.5-m RTT-150 telescope

    Science.gov (United States)

    Bikmaev, I. F.; Nikolaeva, E. A.; Shimansky, V. V.; Galeev, A. I.; Zhuchkov, R. Ya.; Irtuganov, E. N.; Melnikov, S. S.; Sakhibullin, N. A.; Grebenev, S. A.; Sharipova, L. M.

    2017-10-01

    We present the results of our long-term photometric and spectroscopic observations at the Russian-Turkish RTT-150 telescope for the optical counterpart to one of the best-known sources, representatives of the class of fast X-ray transients, IGR J17544-2619. Based on our optical data, we have determined for the first time the orbital and physical parameters of the binary system by the methods of Doppler spectroscopy.We have calculated theoretical spectra of the optical counterpart by applying non- LTE corrections for selected lines and obtained the parameters of the stellar atmosphere ( T eff = 33 000 K, log g = 3.85, R = 9.5 R ⊙, and M = 23 M ⊙). The latter suggest that the optical star is not a supergiant as has been thought previously.

  16. Surgical Management of Chronic Pancreatitis.

    Science.gov (United States)

    Parekh, Dilip; Natarajan, Sathima

    2015-10-01

    Advances over the past decade have indicated that a complex interplay between environmental factors, genetic predisposition, alcohol abuse, and smoking lead towards the development of chronic pancreatitis. Chronic pancreatitis is a complex disorder that causes significant and chronic incapacity in patients and a substantial burden on the society. Major advances have been made in the etiology and pathogenesis of this disease and the role of genetic predisposition is increasingly coming to the fore. Advances in noninvasive diagnostic modalities now allow for better diagnosis of chronic pancreatitis at an early stage of the disease. The impact of these advances on surgical treatment is beginning to emerge, for example, patients with certain genetic predispositions may be better treated with total pancreatectomy versus lesser procedures. Considerable controversy remains with respect to the surgical management of chronic pancreatitis. Modern understanding of the neurobiology of pain in chronic pancreatitis suggests that a window of opportunity exists for effective treatment of the intractable pain after which central sensitization can lead to an irreversible pain syndrome in patients with chronic pancreatitis. Effective surgical procedures exist for chronic pancreatitis; however, the timing of surgery is unclear. For optimal treatment of patients with chronic pancreatitis, close collaboration between a multidisciplinary team including gastroenterologists, surgeons, and pain management physicians is needed.

  17. The Punta del Este Suspect Terrane: a possible counterpart in Eastern Uruguay of the Namaqua Complex and Gariep Belt in Western Africa

    International Nuclear Information System (INIS)

    Preciozzi, F.; Basei, M.; Peel, E.

    2005-01-01

    two tectono-stratigraphic sets with the eastern portion occupied by parautochthonous units of a passive continental margin (Port Nolloth Zone) and a western allochthonous domain (Marmora Terrane). The evidences of blueschist facies metamorphism, countless times referred in the literature (Kröner, 1974; Porada, 1979), have been recently ruled out by Frimmel and Hartnady (1992). The sedimentation period of the Gariep Group is attributed to the Neoproterozoic because it lays discordantly on the rhyolite units (Ross Pinah Formation) dated by the single zircon evaporation technique as 735Ma (Frimmel, 1995). Meert §& Van der Voo (1994) correlated diamictite intercalations, probably of age between 580 and 560 Ma, in the upper portion of the Gariep Group with the glacial deposits of Vendian age. The northeastern portion of the Gariep Group is covered by not metamorphosed sediments of the Nama Group. In the South-American counterpart, that is, the South-Brazilian region and the Uruguayan territory, an old western domain is observed The Central Domain is represented by the Rio de La Plata Craton (sensus Almeida et al.,1973) ,by de Nico Perez Terrane (Bossi et al.,1992 ;Valentines Block,PavasTerrane (Preciozzi et al.,1979) and the Rivera granitic-gneissic complex ..All of them were generated or intensively reworked during the Neoproterozoic, distributed along its eastern border and as a whole organised in the NE-SW direction. In these domain, a granitic-migmatitic infrastructure and sedimentary basins and low- to medium metamorphic grade covers predominate, related to the Lavalleja-supergroup and Zanja del Cerro Grande Group The Rocha formation is developed as a metasedimentary cover in the Punta del Este Terrane,being associated to the Atlantic Domain. Geochronologic studies recently performed in the southeastern portion of Uruguay allowed the identification of igneous rocks with U-Pb ages in zircons ranging from 650 to 1000Ma. These ages, added to the geological

  18. Improving Chronic Disease Self-Management by Older Home Health Patients through Community Health Coaching

    Directory of Open Access Journals (Sweden)

    Cheryl Dye

    2018-04-01

    Full Text Available The purpose of the study was to pilot test a model to reduce hospital readmissions and emergency department use of rural, older adults with chronic diseases discharged from home health services (HHS through the use of volunteers. The study’s priority population consistently experiences poorer health outcomes than their urban counterparts due in part to lower socioeconomic status, reduced access to health services, and incidence of chronic diseases. When they are hospitalized for complications due to poorly managed chronic diseases, they are frequently readmitted for the same conditions. This pilot study examines the use of volunteer community members who were trained as Health Coaches to mentor discharged HHS patients in following the self-care plan developed by their HHS RN; improving chronic disease self-management behaviors; reducing risk of falls, pneumonia, and flu; and accessing community resources. Program participants increased their ability to monitor and track their chronic health conditions, make positive lifestyle changes, and reduce incidents of falls, pneumonia and flu. Although differences in the ED and hospital admission rates after discharge from HHS between the treatment and comparison group (matched for gender, age, and chronic condition were not statistically significant, the treatment group’s rate was less than the comparison group thus suggesting a promising impact of the HC program (90 day: 263 comparison vs. 129 treatment; p = 0.65; 180 day 666.67 vs. 290.32; p = 0.19. The community health coach model offers a potential approach for improving the ability of discharged older home health patients to manage chronic conditions and ultimately reduce emergent care.

  19. [Chronic tophaceous gout].

    Science.gov (United States)

    González-Rozas, M; Prieto de Paula, J M; Franco Hidalgo, S; López Pedreira, M R

    2013-09-01

    Gout is a common illness, usually of unknown etiology, is more frequent in men, and with a prevalence that increases with age. It is characterized by recurrent episodes of acute arthritis due to the deposition of monosodium urate crystals in joints. The underlying disorder in most cases is hyperuricemia, usually as a consequence of impairment in its renal excretion. Although it is generally believed that both the diagnosis and treatment are simple, the truth is that the level of adherence of clinical decisions using the existing guidelines is poor. We describe a case of chronic tophaceous gout, and review the general characteristics of this condition. Copyright © 2011 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España. All rights reserved.

  20. Chronic hypophosphatemic osteopathy

    International Nuclear Information System (INIS)

    Koppers, B.; Schmid, L.; Hofmann, E.; Sauer, E.; Technische Univ. Muenchen; Technische Univ. Muenchen; Technische Univ. Muenchen

    1980-01-01

    The process of chronic hypophosphatemic vitamine D-resistant rickets - observation of two cases. With the male patient - our first case - the disease was sporadic and had not been recognized for a long time. In his early adulthood it manifested itself as Umbauzonen (pseudofractures) in the larger context of active osteomalacia. It was possible to observe the pseudofractures before and while the patient was medicamentously treated. High doses of vitamine D 3 and dosage of phosphate mitigated the complains although with respect to the radiological, scintigraphical, humoral and histological findings there was only slow improvement or nor improvement at all. The patient's daughter is affected by the disease as well. In her case the pathological signs of her bones became better when treated with vitamine D 3. (orig.) [de

  1. Chronic hypophosphatemic osteopathy

    Energy Technology Data Exchange (ETDEWEB)

    Koppers, B.; Schmid, L.; Hofmann, E.; Sauer, E.

    1980-07-01

    The process of chronic hypophosphatemic vitamine D-resistant rickets is described by observation of two cases. With the male patient - our first case - the disease was sporadic and had not been recognized for a long time. In his early adulthood it manifested itself as Umbauzonen (pseudofractures) in the larger context of active osteomalacia. It was possible to observe the pseudofractures before and while the patient was medicamentously treated. High doses of vitamine D 3 and dosage of phosphate mitigated the complaints although with respect to the radiological, scintigraphical, humoral and histological findings there was only slow improvement or no improvement at all. The patient's daughter is affected by the disease as well. In her case the pathological signs of her bones became better when treated with vitamine D 3.

  2. Refractory chronic migraine

    DEFF Research Database (Denmark)

    Martelletti, Paolo; Katsarava, Zaza; Lampl, Christian

    2014-01-01

    The debate on the clinical definition of refractory Chronic Migraine (rCM) is still far to be concluded. The importance to create a clinical framing of these rCM patients resides in the complete disability they show, in the high risk of serious adverse events from acute and preventative drugs...... and in the uncontrolled application of therapeutic techniques not yet validated.The European Headache Federation Expert Group on rCM presents hereby the updated definition criteria for this harmful subset of headache disorders. This attempt wants to be the first impulse towards the correct identification...... of these patients, the correct application of innovative therapeutic techniques and lastly aim to be acknowledged as clinical entity in the next definitive version of the International Classification of Headache Disorders 3 (ICHD-3 beta)....

  3. [Chronic hypertension and pregnancy].

    Science.gov (United States)

    Lecarpentier, Edouard; Tsatsaris, Vassili

    2012-09-01

    Hypertensive disorders in pregnancy are a leading cause of maternal and perinatal mortality and morbidity. The management of patients with chronic hypertension requires a multidisciplinary approach prior to conception, during pregnancy and post-partum. In the preconception period, fetotoxic agents should be discontinued. It is also essential to undertake a full cardiovascular examination which may, in some cases, question the possibility of pregnancy. During pregnancy, blood pressure should be monitored and controlled, but not necessarily returned to a normal value. Low blood pressure levels could indeed lead to placental hypoperfusion and fetal growth restriction. Close clinical, biological and ultrasound monitoring is recommended, even postpartum, since those patients are at higher risk for preeclampsia.

  4. Pediatric chronic nonbacterial osteomyelitis.

    Science.gov (United States)

    Borzutzky, Arturo; Stern, Sara; Reiff, Andreas; Zurakowski, David; Steinberg, Evan A; Dedeoglu, Fatma; Sundel, Robert P

    2012-11-01

    Little information is available concerning the natural history and optimal treatment of chronic nonbacterial osteomyelitis (CNO). We conducted a retrospective review to assess the clinical characteristics and treatment responses of a large cohort of pediatric CNO patients. Children diagnosed with CNO at 3 tertiary care centers in the United States between 1985 and 2009 were identified. Their charts were reviewed, and clinical, laboratory, histopathologic, and radiologic data were extracted. Seventy children with CNO (67% female patients) were identified. Median age at onset was 9.6 years (range 3-17), and median follow-up was 1.8 years (range 0-13). Half of the patients had comorbid autoimmune diseases, and 49% had a family history of autoimmunity. Patients with comorbid autoimmune diseases had more bone lesions (P coexisting autoimmunity was a risk factor for multifocal involvement and treatment with immunosuppressive agents. Disease-modifying antirheumatic drugs and biologics were more likely to lead to clinical improvement than NSAIDs.

  5. Chronic female pelvic pain

    Directory of Open Access Journals (Sweden)

    Gaurab Maitra

    2013-01-01

    Full Text Available Chronic pelvic pain (CPP is defined as nonmalignant pain perceived in the structures related to the pelvis that has been present for more than 6 months or a non acute pain mechanism of shorter duration. Pain in the pelvic region can arise from musculoskeletal, gynaecological, urologic, gastrointestinal and or neurologic conditions. Key gynaecological conditions that contribute to CPP include pelvic inflammatory disease (PID, endometriosis, adnexa pathologies (ovarian cysts, ovarian remnant syndrome, uterine pathologies (leiomyoma, adenomyosis and pelvic girdle pain associated with pregnancy. Several major and minor sexually transmitted diseases (STD can cause pelvic and vulvar pain. A common painful condition of the urinary system is Interstitial cystitis(IC. A second urologic condition that can lead to development of CPP is urethral syndrome. Irritable bowel syndrome (IBS is associated with dysmenorrhoea in 60% of cases. Other bowel conditions contributing to pelvic pain include diverticular disease,Crohn′s disease ulcerative colitis and chronic appendicitis. Musculoskeletal pathologies that can cause pelvic pain include sacroiliac joint (SIJ dysfunction, symphysis pubis and sacro-coccygeal joint dysfunction, coccyx injury or malposition and neuropathic structures in the lower thoracic, lumbar and sacral plexus. Prolonged pelvic girdle pain, lasting more than 6 months postpartum is estimated in 3% to 30% of women. Nerve irritation or entrapment as a cause of pelvic pain can be related to injury of the upper lumbar segments giving rise to irritation of the sensory nerves to the ventral trunk or from direct trauma from abdominal incisions or retractors used during abdominal surgical procedures. Afflictions of the iliohypogastric, ilioinguinal, genitofemoral, pudendal and obturator nerves are of greatest concern in patients with pelvic pain. Patient education about the disease and treatment involved is paramount. A knowledge of the differential

  6. Chronic diseases and mental disorder.

    NARCIS (Netherlands)

    Verhaak, P.F.M.; Heijmans, M.J.W.M.; Peters, L.; Rijken, M.

    2005-01-01

    The aim of this study was to achieve a better understanding of the relationship between chronic medical illness and mental distress. Therefore, the association between chronic medical illness and mental distress was analysed, taking into account the modifying effects of generic disease

  7. Defining and Measuring Chronic Conditions

    Centers for Disease Control (CDC) Podcasts

    This podcast is an interview with Dr. Anand Parekh, U.S. Department of Health and Human Services Deputy Assistant Secretary for Health, and Dr. Samuel Posner, Preventing Chronic Disease Editor in Chief, about the definition and burden of multiple chronic conditions in the United States.

  8. Chronic sleep reduction in adolescents

    NARCIS (Netherlands)

    Dewald-Kaufmann, J.F.

    2012-01-01

    Based on the results of this thesis, it can be concluded that sleep problems and chronic sleep reduction have a high impact on adolescents’ daytime functioning. Additionally, this research shows that gradual sleep extension can improve adolescents’ sleep and especially their chronic sleep reduction.

  9. Anemia in Chronic Kidney Disease

    Science.gov (United States)

    ... Cysts Solitary Kidney Your Kidneys & How They Work Anemia in Chronic Kidney Disease What is anemia? Anemia is a condition in which the body ... function as well as they should. How is anemia related to chronic kidney disease? Anemia commonly occurs ...

  10. Treatment Option Overview (Chronic Myelogenous Leukemia)

    Science.gov (United States)

    ... ALL Treatment Childhood AML Treatment Research Chronic Myelogenous Leukemia Treatment (PDQ®)–Patient Version General Information About Chronic Myelogenous Leukemia Go to Health Professional Version Key Points Chronic ...

  11. General Information about Chronic Myelogenous Leukemia

    Science.gov (United States)

    ... ALL Treatment Childhood AML Treatment Research Chronic Myelogenous Leukemia Treatment (PDQ®)–Patient Version General Information About Chronic Myelogenous Leukemia Go to Health Professional Version Key Points Chronic ...

  12. Chronic inflammatory and suppurative processes in lungs

    International Nuclear Information System (INIS)

    Rozenshtraukh, L.C.; Rybakova, N.I.; Vinner, M.G.

    1987-01-01

    Roentgenologic methods of diagnosis of chronic bronchitis, bronchiectatic disease, lung abscess and gangrene, chronic non-specific pneumonia and cancer of lung and other pathalogical changes at chronic processes in lungs are discussed in detail

  13. Eosinophilic Chronic Rhinosinusitis in Japan

    Directory of Open Access Journals (Sweden)

    Junichi Ishitoya

    Full Text Available ABSTRACT: Chronic rhinosinusitis is a heterogeneous disease. In Europe and the United States, it has recently been divided into two subgroups: chronic rhinosinusitis with nasal polyps (CRSwNP and chronic rhinosinusitis without nasal polyps (CRSsNP. The majority of CRSwNP cases have a strong tendency to recur after surgery and show eosinophil-dominant inflammation. However, this definition has proved difficult to apply in Japan and East Asia, because more than half of the CRSwNP cases do not exhibit eosinophil-dominant inflammation in these areas of the world. In Japan in the 1990s, refractory CRSwNP to the standard treatment was focused on in clinical studies and the term ''eosinophilic chronic rhinosinusitis'' (ECRS was introduced to identify this subgroup of chronic rhinosinusitis in 2001.ECRS is different from non-ECRS in terms of many clinical features: symptom appearance, occurrence site of nasal polyps, CT scan findings, the histology of nasal polyps, blood examination findings, clinical course after surgery, and co-morbid asthma, etc. In this review, we describe these clinical features and mention how to make a clinical diagnosis of ECRS as well as how to treat it. Finally, we discuss the pathophysiology of ECRS. The concept of ECRS in Japan would be applicable for CRSwNP in other countries including Europe and the United States. KEY WORDS: chronic rhinosinusitis, clinical feature, diagnosis, eosinophilic chronic rhinosinusitis, eosinophils

  14. Common Questions About Chronic Prostatitis.

    Science.gov (United States)

    Holt, James D; Garrett, W Allan; McCurry, Tyler K; Teichman, Joel M H

    2016-02-15

    Chronic prostatitis is relatively common, with a lifetime prevalence of 1.8% to 8.2%. Risk factors include conditions that facilitate introduction of bacteria into the urethra and prostate (which also predispose the patient to urinary tract infections) and conditions that can lead to chronic neuropathic pain. Chronic prostatitis must be differentiated from other causes of chronic pelvic pain, such as interstitial cystitis/bladder pain syndrome and pelvic floor dysfunction; prostate and bladder cancers; benign prostatic hyperplasia; urolithiasis; and other causes of dysuria, urinary frequency, and nocturia. The National Institutes of Health divides prostatitis into four syndromes: acute bacterial prostatitis, chronic bacterial prostatitis (CBP), chronic nonbacterial prostatitis (CNP)/chronic pelvic pain syndrome (CPPS), and asymptomatic inflammatory prostatitis. CBP and CNP/CPPS both lead to pelvic pain and lower urinary tract symptoms. CBP presents as recurrent urinary tract infections with the same organism identified on repeated cultures; it responds to a prolonged course of an antibiotic that adequately penetrates the prostate, if the urine culture suggests sensitivity. If four to six weeks of antibiotic therapy is effective but symptoms recur, another course may be prescribed, perhaps in combination with alpha blockers or nonopioid analgesics. CNP/CPPS, accounting for more than 90% of chronic prostatitis cases, presents as prostatic pain lasting at least three months without consistent culture results. Weak evidence supports the use of alpha blockers, pain medications, and a four- to six-week course of antibiotics for the treatment of CNP/CPPS. Patients may also be referred to a psychologist experienced in managing chronic pain. Experts on this condition recommend a combination of treatments tailored to the patient's phenotypic presentation. Urology referral should be considered when appropriate treatment is ineffective. Additional treatments include pelvic

  15. [Chronically ill--chronically forgotten?--communication/mobility/everyday life].

    Science.gov (United States)

    Mattern, R

    2007-04-01

    In the course of the recent years, the policy for the needs of disabled people has started a fundamental paradigm shift. Central elements of the current policy for the needs of disabled people are prevention, rehabilitation and integration. Self-determination instead of care forms the guiding principle. An indistinct definition of chronic disease makes it difficult to obtain a general idea of structures in the care and support for people with chronic diseases. The following compilation examines requirements in social legislation and questions the quality of life by means of the three exemplary aspects: communication, mobility and everyday life. Here the question remains whether the current focus on health neglects any relevant components of chronic diseases. It turns out that people with a chronic illness, although social legislation has improved, are neglected the more support they need. Care as an elementary social principle must be discussed on an interdisciplinary basis and in the context of the whole society.

  16. Chronic conditions, fluid states: chronicity and the anthropology of illness

    National Research Council Canada - National Science Library

    Manderson, Lenore; Smith-Morris, Carolyn

    2010-01-01

    .... Breaking new ground in medical anthropology by challenging the chronic/acute divide in illness and disease, the editors, along with a group of rising scholars and some of the most influential minds...

  17. Chronic conditions, fluid states: chronicity and the anthropology of illness

    National Research Council Canada - National Science Library

    Manderson, Lenore; Smith-Morris, Carolyn

    2010-01-01

    ... in the field, address the concept of chronicity, an idea used to explain individual and local life-worlds, question public health discourse, and consider the relationship between health and the globalizing forces that shape it."--pub. desc.

  18. Chronic infections in hip arthroplasties

    DEFF Research Database (Denmark)

    Lange, Jeppe; Troelsen, Anders; Thomsen, Reimar W

    2012-01-01

    Two-stage revision is regarded by many as the best treatment of chronic infection in hip arthroplasties. Some international reports, however, have advocated one-stage revision. No systematic review or meta-analysis has ever compared the risk of reinfection following one-stage and two-stage revisi......Two-stage revision is regarded by many as the best treatment of chronic infection in hip arthroplasties. Some international reports, however, have advocated one-stage revision. No systematic review or meta-analysis has ever compared the risk of reinfection following one-stage and two......-stage revisions for chronic infection in hip arthroplasties....

  19. Gastric emptying in chronic dyspepsia

    International Nuclear Information System (INIS)

    Sielaff, F.; Jahnel, P.; Sest, C.; Sydow, K.; Sapia, C.; Hass, A.; Buchali, K.

    1987-01-01

    Gastric emptying of a semiliquid test meal with 5 MBq /sup 99m/Tc-sulfur colloid as a marker was measured in 97 chronic dyspeptic patients and 16 healthy subjects. A comparison of half emptying time between both showed that chronic dyspeptic patients empty semiliquid meal at a significantly (p < 0.005) slower rate (at 70 +- 33 min) than healthy controls (at 52 x 20 min). The studies indicate that gastric stasis in chronic dyspepsia is not caused by inflammatory changes in gastric or duodenal mucosa nor by different gastric acid secretion. The presence of stasis cannot be predicted sufficiently by anamnestic complaints or endoscopic findings. (author)

  20. Pathophysiology of chronic pancreatitis.

    Science.gov (United States)

    Brock, Christina; Nielsen, Lecia Møller; Lelic, Dina; Drewes, Asbjørn Mohr

    2013-11-14

    Chronic pancreatitis (CP) is an inflammatory disease of the pancreas characterized by progressive fibrotic destruction of the pancreatic secretory parenchyma. Despite the heterogeneity in pathogenesis and involved risk factors, processes such as necrosis/apoptosis, inflammation or duct obstruction are involved. This fibrosing process ultimately leads to progressive loss of the lobular morphology and structure of the pancreas, deformation of the large ducts and severe changes in the arrangement and composition of the islets. These conditions lead to irreversible morphological and structural changes resulting in impairment of both exocrine and endocrine functions. The prevalence of the disease is largely dependent on culture and geography. The etiological risk-factors associated with CP are multiple and involve both genetic and environmental factors. Throughout this review the M-ANNHEIM classification system will be used, comprising a detailed description of risk factors such as: alcohol-consumption, nicotine-consumption, nutritional factors, hereditary factors, efferent duct factors, immunological factors and miscellaneous and rare metabolic factors. Increased knowledge of the different etiological factors may encourage the use of further advanced diagnostic tools, which potentially will help clinicians to diagnose CP at an earlier stage. However, in view of the multi factorial disease and the complex clinical picture, it is not surprising that treatment of patients with CP is challenging and often unsuccessful.

  1. Pathophysiology of chronic pancreatitis

    Science.gov (United States)

    Brock, Christina; Nielsen, Lecia Møller; Lelic, Dina; Drewes, Asbjørn Mohr

    2013-01-01

    Chronic pancreatitis (CP) is an inflammatory disease of the pancreas characterized by progressive fibrotic destruction of the pancreatic secretory parenchyma. Despite the heterogeneity in pathogenesis and involved risk factors, processes such as necrosis/apoptosis, inflammation or duct obstruction are involved. This fibrosing process ultimately leads to progressive loss of the lobular morphology and structure of the pancreas, deformation of the large ducts and severe changes in the arrangement and composition of the islets. These conditions lead to irreversible morphological and structural changes resulting in impairment of both exocrine and endocrine functions. The prevalence of the disease is largely dependent on culture and geography. The etiological risk-factors associated with CP are multiple and involve both genetic and environmental factors. Throughout this review the M-ANNHEIM classification system will be used, comprising a detailed description of risk factors such as: alcohol-consumption, nicotine-consumption, nutritional factors, hereditary factors, efferent duct factors, immunological factors and miscellaneous and rare metabolic factors. Increased knowledge of the different etiological factors may encourage the use of further advanced diagnostic tools, which potentially will help clinicians to diagnose CP at an earlier stage. However, in view of the multi factorial disease and the complex clinical picture, it is not surprising that treatment of patients with CP is challenging and often unsuccessful. PMID:24259953

  2. Effect of surface reactions on steel, Al{sub 2}O{sub 3} and Si{sub 3}N{sub 4} counterparts on their tribological performance with polytetrafluoroethylene filled composites

    Energy Technology Data Exchange (ETDEWEB)

    Shen, J.T.; Top, M. [Materials Innovation Institute M2i, Department of Applied Physics, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen (Netherlands); Ivashenko, O.; Rudolf, P. [Department of Surfaces and Thin Films, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen (Netherlands); Pei, Y.T., E-mail: y.pei@rug.nl [Materials Innovation Institute M2i, Department of Applied Physics, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen (Netherlands); Department of Advanced Production Engineering, Engineering and Technology Institute Groningen, University of Groningen, Nijenborgh 4, 9747 AG Groningen (Netherlands); De Hosson, J.Th.M., E-mail: j.t.m.de.hosson@rug.nl [Materials Innovation Institute M2i, Department of Applied Physics, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen (Netherlands)

    2015-03-15

    Highlights: • The influence of surface reactions with PTFE on the tribo-performance of different counterparts is revealed. • Experiments confirm that friction can be greatly reduced by two F-terminated surfaces sliding over each other. • Al−F and Fe−F chemical bonding form on the surface of alumina and steel counterpart balls during sliding against PTFE-containing composite. • No Si−F bonding formed on Si{sub 3}N{sub 4} ball under the same condition, leading to higher friction and wear. - Abstract: The influence of surface reactions on the tribo-performance of steel, Al{sub 2}O{sub 3} and Si{sub 3}N{sub 4} balls sliding against polytetrafluoroethylene/SiO{sub 2}/epoxy composites was investigated. Al{sub 2}O{sub 3} ball were found to exhibit the best tribo-performance, namely a low coefficient of friction and the lowest wear rates of both the composites and the counterpart ball, when sliding against the PTFE filled composites. The difference in the tribo-performance of the Al{sub 2}O{sub 3} ball and the Si{sub 3}N{sub 4} ball can neither be attributed to the different morphology of the worn composite surfaces nor to the amount of PTFE transferred onto the wear surfaces. Instead we found that the friction is greatly reduced in the case of the Al{sub 2}O{sub 3} ball because two fluoro-terminated surfaces are sliding over each other; in fact, the formation of Al−F bonding was confirmed by X-ray photoelectron spectroscopy.

  3. Stages of Chronic Lymphocytic Leukemia

    Science.gov (United States)

    ... of the lymph system . Having relatives who are Russian Jews or Eastern European Jews. Signs and symptoms ... information about clinical trials is also available. To Learn More About Chronic Lymphocytic Leukemia For more information ...

  4. Chronic Conditions among Medicare Beneficiaries

    Data.gov (United States)

    U.S. Department of Health & Human Services — The data used in the chronic condition reports are based upon CMS administrative enrollment and claims data for Medicare beneficiaries enrolled in the...

  5. Occupational chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Omland, Oyvind; Würtz, Else Toft; Aasen, Tor Børvig

    2014-01-01

    Occupational-attributable chronic obstructive pulmonary disease (COPD) presents a substantial health challenge. Focusing on spirometric criteria for airflow obstruction, this review of occupational COPD includes both population-wide and industry-specific exposures....

  6. Empowering Patients with Chronic Diseases

    DEFF Research Database (Denmark)

    Bestek, Mate; Meglič, Matic; Kurent, Blaž

    2012-01-01

    Background: Chronic diseases require most of the resources in todays healthcare systems. Healthcare systems, as such, are thus not sustainable in the long term. Solutions to this problem are needed and a lot of research is focused on finding new approaches to more sustainable healthcare systems...... himself to become empowered. The patient needs to see data about his health in order to start thinking about new decisions in life that can lead to change in his behaviour. Objective: We have approached the problem of empowering patients with chronic diseases from a biological, psychological, sociological....... We want to develop extensible technology to support even more new interventions for different chronic diseases. We want the technology to enable semantic interoperability with other systems. Methods: We have collaborated with doctors in order to model the care plans for different chronic diseases...

  7. Diarrheal Diseases - Acute and Chronic

    Science.gov (United States)

    ... include abdominal cramps fever, nausea, vomiting, fatigue and urgency. Chronic diarrhea can be accompanied by weight loss, ... bloating, abdominal pain relieved with defecation and a sense of incomplete evacuation. Risk Factors Exposure to infectious ...

  8. Tai chi and chronic pain.

    Science.gov (United States)

    Peng, Philip W H

    2012-01-01

    In the last 2 decades, a growing body of research aimed at investigating the health benefits of Tai Chi in various chronic health conditions has been recognized in the literature. This article reviewed the history, the philosophy, and the evidence for the role of Tai Chi in a few selected chronic pain conditions. The ancient health art of Tai Chi contributes to chronic pain management in 3 major areas: adaptive exercise, mind-body interaction, and meditation. Trials examining the health benefit of Tai Chi in chronic pain conditions are mostly low quality. Only 5 pain conditions were reviewed: osteoarthritis, fibromyalgia, rheumatoid arthritis, low back pain, and headache. Of these, Tai Chi seems to be an effective intervention in osteoarthritis, low back pain, and fibromyalgia. The limitations of the Tai Chi study design and suggestions for the direction of future research are also discussed.

  9. Surgical Approaches to Chronic Pancreatitis

    Directory of Open Access Journals (Sweden)

    Daniel Hartmann

    2015-01-01

    Full Text Available Chronic pancreatitis is a progressive inflammatory disease resulting in permanent structural damage of the pancreas. It is mainly characterized by recurring epigastric pain and pancreatic insufficiency. In addition, progression of the disease might lead to additional complications, such as pseudocyst formation or development of pancreatic cancer. The medical and surgical treatment of chronic pancreatitis has changed significantly in the past decades. With regard to surgical management, pancreatic head resection has been shown to be a mainstay in the treatment of severe chronic pancreatitis because the pancreatic head mass is known to trigger the chronic inflammatory process. Over the years, organ-preserving procedures, such as the duodenum-preserving pancreatic head resection and the pylorus-preserving Whipple, have become the surgical standard and have led to major improvements in pain relief, preservation of pancreatic function, and quality of life of patients.

  10. Chronic Intermittent Hypoxia Induces Atherosclerosis

    OpenAIRE

    Savransky, Vladimir; Nanayakkara, Ashika; Li, Jianguo; Bevans, Shannon; Smith, Philip L.; Rodriguez, Annabelle; Polotsky, Vsevolod Y.

    2007-01-01

    Rationale: Obstructive sleep apnea, a condition leading to chronic intermittent hypoxia (CIH), is associated with hyperlipidemia, atherosclerosis, and a high cardiovascular risk. A causal link between obstructive sleep apnea and atherosclerosis has not been established.

  11. Diabetes and chronic kidney disease

    African Journals Online (AJOL)

    2007-08-16

    Aug 16, 2007 ... chronic dialysis or transplantation due to significant extrarenal disease, mainly .... including coronary heart disease, silent myocardial ischaemia and left ... diabetics and should be kept in mind: • renal papillary necrosis.

  12. [The magnetotherapy of chronic prostatitis].

    Science.gov (United States)

    Mokhort, V A; Voshchula, V I

    1998-01-01

    Low-frequency magnetic field generated by the unit ProSPOK was found more efficient than that of the unit Polyus-1 in physiotherapy of chronic prostatitis. The ProSPOK magnetotherapy stimulates ganglia, improves regeneration and circulation.

  13. Nitazoxanide for chronic hepatitis C

    DEFF Research Database (Denmark)

    Nikolova, Kristiana; Gluud, Christian; Grevstad, Berit

    2014-01-01

    BACKGROUND: Hepatitis C infection is a disease of the liver caused by the hepatitis C virus. The estimated number of chronically infected people with hepatitis C virus worldwide is about 150 million people. Every year, another three to four million people acquire the infection. Chronic hepatitis C......) and ribavirin was the approved standard treatment for chronic hepatitis C. In 2011, first-generation direct-acting antivirals (DAAs) have been licensed, for use in combination with peginterferon and ribavirin for treating hepatitis C virus genotype 1 infection. Nitazoxanide is another antiviral drug with broad...... antiviral activity and may have potential as an effective alternative, or an addition to standard treatment for the treatment of the hepatitis C virus. OBJECTIVES: To assess the benefits and harms of nitazoxanide in people with chronic hepatitis C virus infection. SEARCH METHODS: We searched The Cochrane...

  14. Pharmacological challenges in chronic pancreatitis

    OpenAIRE

    Olesen, Anne Estrup; Brokjaer, Anne; Fisher, Iben Wendelboe; Larsen, Isabelle Myriam

    2013-01-01

    Drug absorption in patients with chronic pancreatitis might be affected by the pathophysiology of the disease. The exocrine pancreatic insufficiency is associated with changes in gastrointestinal intraluminal pH, motility disorder, bacterial overgrowth and changed pancreatic gland secretion. Together these factors can result in malabsorption and may also affect the efficacy of pharmacological intervention. The lifestyle of chronic pancreatitis patients may also contribute to gastrointestinal ...

  15. Chronic subdural hematoma

    Science.gov (United States)

    Yadav, Yad R.; Parihar, Vijay; Namdev, Hemant; Bajaj, Jitin

    2016-01-01

    Chronic subdural hematoma (CSDH) is one of the most common neurosurgical conditions. There is lack of uniformity in the treatment of CSDH amongst surgeons in terms of various treatment strategies. Clinical presentation may vary from no symptoms to unconsciousness. CSDH is usually diagnosed by contrast-enhanced computed tomography scan. Magnetic resonance imaging (MRI) scan is more sensitive in the diagnosis of bilateral isodense CSDH, multiple loculations, intrahematoma membranes, fresh bleeding, hemolysis, and the size of capsule. Contrast-enhanced CT or MRI could detect associated primary or metastatic dural diseases. Although definite history of trauma could be obtained in a majority of cases, some cases may be secondary to coagulation defect, intracranial hypotension, use of anticoagulants and antiplatelet drugs, etc., Recurrent bleeding, increased exudates from outer membrane, and cerebrospinal fluid entrapment have been implicated in the enlargement of CSDH. Burr-hole evacuation is the treatment of choice for an uncomplicated CSDH. Most of the recent trials favor the use of drain to reduce recurrence rate. Craniotomy and twist drill craniostomy also play a role in the management. Dural biopsy should be taken, especially in recurrence and thick outer membrane. Nonsurgical management is reserved for asymptomatic or high operative risk patients. The steroids and angiotensin converting enzyme inhibitors may also play a role in the management. Single management strategy is not appropriate for all the cases of CSDH. Better understanding of the nature of the pathology, rational selection of an ideal treatment strategy for an individual patient, and identification of the merits and limitations of different surgical techniques could help in improving the prognosis. PMID:27695533

  16. Comparison of Health Information Technology Use Between American Adults With and Without Chronic Health Conditions: Findings From The National Health Interview Survey 2012.

    Science.gov (United States)

    Zhang, Yan; Lauche, Romy; Sibbritt, David; Olaniran, Bolanle; Cook, Ronald; Adams, Jon

    2017-10-05

    Health information technology (HIT) is utilized by people with different chronic conditions such as diabetes and hypertension. However, there has been no comparison of HIT use between persons without a chronic condition, with one chronic condition, and multiple (≥2) chronic conditions (MCCs). The aim of the study was to assess the difference in HIT use between persons without a chronic condition, with one chronic condition, and with MCCs, to describe the characteristics of HIT use among those with chronic conditions and to identify the predictors of HIT use of the persons with one chronic condition and MCCs. A secondary data analysis was conducted in spring 2017 using the National Health Interview Survey (NHIS) 2012 Family Core and Sample Adult Core datasets that yielded 34,525 respondents aged 18 years and older. Measures included overall HIT use (ie, any use of the following five HIT on the Internet: seeking health information, ordering prescription, making appointment, emailing health provider, and using health chat groups), as well as sociodemographic and health-related characteristics. Sociodemographic and health characteristics were compared between HIT users and nonusers among those who reported having at least one chronic condition using chi-square tests. Independent predictors of HIT use were identified using multiple logistic regression analyses for those with one chronic condition, with MCCs, and without a chronic condition. Analyses were weighted and performed at significance level of .005. In 2012, adults with one health chronic condition (raw count 4147/8551, weighted percentage 48.54%) was significantly higher than among those with MCCs (3816/9637, 39.55%) and those with none of chronic condition (7254/16,337, 44.40%, PHIT use. Chi-square tests revealed that among adults with chronic conditions, those who used HIT were significantly different from their counterpart peers who did not use HIT in terms of sociodemographic and health characteristics

  17. Neurovascular Unit in Chronic Pain

    Directory of Open Access Journals (Sweden)

    Beatrice Mihaela Radu

    2013-01-01

    Full Text Available Chronic pain is a debilitating condition with major socioeconomic impact, whose neurobiological basis is still not clear. An involvement of the neurovascular unit (NVU has been recently proposed. In particular, the blood-brain barrier (BBB and blood-spinal cord barrier (BSCB, two NVU key players, may be affected during the development of chronic pain; in particular, transient permeabilization of the barrier is suggested by several inflammatory- and nerve-injury-based pain models, and we argue that the clarification of molecular BBB/BSCB permeabilization events will shed new light in understanding chronic pain mechanisms. Possible biases in experiments supporting this theory and its translational potentials are discussed. Moving beyond an exclusive focus on the role of the endothelium, we propose that our understanding of the mechanisms subserving chronic pain will benefit from the extension of research efforts to the NVU as a whole. In this view, the available evidence on the interaction between analgesic drugs and the NVU is here reviewed. Chronic pain comorbidities, such as neuroinflammatory and neurodegenerative diseases, are also discussed in view of NVU changes, together with innovative pharmacological solutions targeting NVU components in chronic pain treatment.

  18. Chronic Cough in Otorhinolaryngologic Routine

    Directory of Open Access Journals (Sweden)

    Palheta Neto, Francisco Xavier

    2011-04-01

    Full Text Available Introduction: The chronic cough is sometimes manifested as an imprecise symptom, but of great importance for both the diagnosis and the prognosis. In an otorhinolaryngologic approach, several illnesses that can occur with it can be numbered, including 2 of the 3 main causes of chronic cough. Objective: To identify the main otorhinolaryngologic diseases showing the chronic cough as one of their manifestations. Method: A literature's revision was performed in several scientific articles, specialized books and consultation in Birene and Scielo databases. Literature's revision: cough production in the upper airways is usually associated with an inflammatory reaction by stimulating sensitive receptors of these areas or by mechanic stimulus. The main cause of the chronic cough in the otorhinolaryngology day-to-day is the post-nasal drip, gathering together by itself 02 of the most common diseases: rhinitis and sinusitis. Laryngitis as a result of gastroesophageal reflux (GER stands out in the index of chronic cough etiology, but it is not as severe as GER . Neoplasias are also somewhat frequent causes of cough, and the difficulty in diagnosing the cough cause is common in this disease group. Motility disorder, laryngeal irritation persistence, parasitic disease and injuries by inhalation of toxic products were also found as a cause of cough for longer than 03 months. Conclusion:Chronic cough is a frequent and important finding in otorhinolaryngology and cannot be underestimated, and a careful anamnesis is the best way to determine the etiology and perform a correct treatment for the patient's disease.

  19. The effects of obesity on doctor-diagnosed chronic diseases in Africa: empirical results from Senegal and South Africa.

    Science.gov (United States)

    Asfaw, Abay

    2006-01-01

    While inadequate food and communicable infectious diseases have been a concern of researchers and policy makers in Africa, little attention has been given to obesity and chronic, non-communicable diseases. Africa is not usually associated with obesity and chronic diseases. Yet there has been a sharp rise in the incidence of obesity and chronic diseases, a major public health problem in many countries. The paper examines the impact of obesity on the prevalence of four doctor-diagnosed chronic diseases in Senegal and South Africa. The results reveal that obese respondents were 4.7, 2.8, and 4.8% more likely to face the risks of arthritis, diabetes, and heart diseases in South Africa and 6.5 and 7.4% more likely to face the risks of heart disease and asthma in Senegal than their lean counterparts. Obesity imposes a real and substantial danger, affecting the prevalence of chronic diseases. Unchecked it can be a major public health problem, impose a serious challenge to the health sector, and can jeopardize future developments.

  20. Searching the Gamma-Ray Sky for Counterparts to Gravitational Wave Sources Fermi Gamma-Ray Burst Monitor and Large Area Telescope Observations of LVT151012 and GW151226

    Science.gov (United States)

    Racusin, J. L.; Burns, E.; Goldstein, A.; Connaughton, V.; Wilson-Hodge, C. A.; Jenke, P.; Blackburn, L.; Briggs, M. S.; Broida, J.; Camp, J.; hide

    2017-01-01

    We present the Fermi Gamma-ray Burst Monitor (GBM) and Large Area Telescope (LAT) observations of the LIGO binary black hole merger event GW151226 and candidate LVT151012. At the time of the LIGO triggers on LVT151012 and GW151226, GBM was observing 68% and 83% of the localization regions, and LAT was observing 47% and 32%, respectively. No candidate electromagnetic counterparts were detected by either the GBM or LAT. We present a detailed analysis of the GBM and LAT data over a range of timescales from seconds to years, using automated pipelines and new techniques for characterizing the flux upper bounds across large areas of the sky. Due to the partial GBM and LAT coverage of the large LIGO localization regions at the trigger times for both events, differences in source distances and masses, as well as the uncertain degree to which emission from these sources could be beamed, these non-detections cannot be used to constrain the variety of theoretical models recently applied to explain the candidate GBM counterpart to GW150914.

  1. SEARCHING THE GAMMA-RAY SKY FOR COUNTERPARTS TO GRAVITATIONAL WAVE SOURCES: FERMI GAMMA-RAY BURST MONITO R AND LARGE AREA TELESCOPE OBSERVATIONS OF LVT151012 AND GW151226

    Energy Technology Data Exchange (ETDEWEB)

    Racusin, J. L.; Camp, J.; Singer, L. [NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Burns, E. [Physics Dept, University of Alabama in Huntsville, 320 Sparkman Dr., Huntsville, AL 35805 (United States); Goldstein, A.; Connaughton, V.; Littenberg, T.; Cleveland, W. [Universities Space Research Association, 320 Sparkman Dr. Huntsville, AL 35806 (United States); Wilson-Hodge, C. A.; Hui, C. M. [Astrophysics Office, ZP12, NASA/Marshall Space Flight Center, Huntsville, AL 35812 (United States); Jenke, P.; Briggs, M. S.; Bhat, P. N. [CSPAR, University of Alabama in Huntsville, 320 Sparkman Dr., Huntsville, AL 35805 (United States); Blackburn, L. [LIGO, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Broida, J.; Christensen, N. [Physics and Astronomy, Carleton College, MN 55057 (United States); Shawhan, P. [Department of Physics, University of Maryland, College Park, MD 20742 (United States); Veitch, J. [University of Birmingham, Birmingham B15 2TT (United Kingdom); Fitzpatrick, G. [School of Physics, University College Dublin, Belfield, Stillorgan Road, Dublin 4 (Ireland); Gibby, M. H. [Jacobs Technology, Inc., Huntsville, AL (United States); Collaboration: Fermi LAT Collaboration; and others

    2017-01-20

    We present the Fermi Gamma-ray Burst Monitor (GBM) and Large Area Telescope (LAT) observations of the LIGO binary black hole merger event GW151226 and candidate LVT151012. At the time of the LIGO triggers on LVT151012 and GW151226, GBM was observing 68% and 83% of the localization regions, and LAT was observing 47% and 32%, respectively. No candidate electromagnetic counterparts were detected by either the GBM or LAT. We present a detailed analysis of the GBM and LAT data over a range of timescales from seconds to years, using automated pipelines and new techniques for characterizing the flux upper bounds across large areas of the sky. Due to the partial GBM and LAT coverage of the large LIGO localization regions at the trigger times for both events, differences in source distances and masses, as well as the uncertain degree to which emission from these sources could be beamed, these non-detections cannot be used to constrain the variety of theoretical models recently applied to explain the candidate GBM counterpart to GW150914.

  2. 中国灾区重建对口支援政策之分析——以汶川地震为例%An Analysis on Counterpart Assistance Policy for Wenchuan

    Institute of Scientific and Technical Information of China (English)

    沈文伟; 黄月珍

    2012-01-01

    本文就Popple&Leighninger’s(2011)“抉择分析”(ChoiceAnalysis),针对中国汶川救灾重建《对口支援》政策进行四个层面的分析:(一)筛选基础;(二)资金开源;(三)政策推行;(四)受益类型。进而,带出中国垂直的政策制定结构的特点,供国外治理灾害参考、对比。%The aim of this paper is to contribute to knowledge on the post-disaster restoration in China, within the context of a twinned provinces assistance policy. Using Popple & Leighninger's (2011) "choice analysis", this paper examines four dimensions of China's counterpart assistance policy decisions : bases of allocations; financing benefits; delivery structure; and types of benefits. Furthermore, much scholarship on China emphasizes its vertical policy-making structure and does not pay as much attention to its horizontal approach of policy administration. China's counterpart assistance policy serves to illustrate the horizontal nature of partnerships in China.

  3. Chronic Kidney Disease.

    Science.gov (United States)

    Webster, Angela C; Nagler, Evi V; Morton, Rachael L; Masson, Philip

    2017-03-25

    The definition and classification of chronic kidney disease (CKD) have evolved over time, but current international guidelines define this condition as decreased kidney function shown by glomerular filtration rate (GFR) of less than 60 mL/min per 1·73 m 2 , or markers of kidney damage, or both, of at least 3 months duration, regardless of the underlying cause. Diabetes and hypertension are the main causes of CKD in all high-income and middle-income countries, and also in many low-income countries. Incidence, prevalence, and progression of CKD also vary within countries by ethnicity and social determinants of health, possibly through epigenetic influence. Many people are asymptomatic or have non-specific symptoms such as lethargy, itch, or loss of appetite. Diagnosis is commonly made after chance findings from screening tests (urinary dipstick or blood tests), or when symptoms become severe. The best available indicator of overall kidney function is GFR, which is measured either via exogenous markers (eg, DTPA, iohexol), or estimated using equations. Presence of proteinuria is associated with increased risk of progression of CKD and death. Kidney biopsy samples can show definitive evidence of CKD, through common changes such as glomerular sclerosis, tubular atrophy, and interstitial fibrosis. Complications include anaemia due to reduced production of erythropoietin by the kidney; reduced red blood cell survival and iron deficiency; and mineral bone disease caused by disturbed vitamin D, calcium, and phosphate metabolism. People with CKD are five to ten times more likely to die prematurely than they are to progress to end stage kidney disease. This increased risk of death rises exponentially as kidney function worsens and is largely attributable to death from cardiovascular disease, although cancer incidence and mortality are also increased. Health-related quality of life is substantially lower for people with CKD than for the general population, and falls as GFR

  4. Diagnosis and management of chronic pancreatitis

    OpenAIRE

    Gupta, V; Toskes, P

    2005-01-01

    Chronic pancreatitis represents a condition that is challenging for clinicians secondary to the difficulty in making an accurate diagnosis and the less than satisfactory means of managing chronic pain. This review emphasises the various manifestations that patients with chronic pancreatitis may have and describes recent advances in medical and surgical therapy. It is probable that many patients with chronic abdominal pain are suffering from chronic pancreatitis that is not appreciated. As the...

  5. Periodontitis in Chronic Heart Failure.

    Science.gov (United States)

    Fröhlich, Hanna; Herrmann, Kristina; Franke, Jennifer; Karimi, Alamara; Täger, Tobias; Cebola, Rita; Katus, Hugo A; Zugck, Christian; Frankenstein, Lutz

    2016-08-01

    Periodontal disease has been associated with an increased risk of cardiovascular events. The purpose of our study was to investigate whether a correlation between periodontitis and chronic heart failure exists, as well as the nature of the underlying cause. We enrolled 71 patients (mean age, 54 ± 13 yr; 56 men) who had stable chronic heart failure; all underwent complete cardiologic and dental evaluations. The periodontal screening index was used to quantify the degree of periodontal disease. We compared the findings to those in the general population with use of data from the 4th German Dental Health Survey. Gingivitis, moderate periodontitis, and severe periodontitis were present in 17 (24%), 17 (24%), and 37 (52%) patients, respectively. Severe periodontitis was more prevalent among chronic heart failure patients than in the general population. In contrast, moderate periodontitis was more prevalent in the general population (P periodontal disease was not associated with the cause of chronic heart failure or the severity of heart failure symptoms. Six-minute walking distance was the only independent predictor of severe periodontitis. Periodontal disease is highly prevalent in chronic heart failure patients regardless of the cause of heart failure. Prospective trials are warranted to clarify the causal relationship between both diseases.

  6. Conservative treatment of chronic pancreatitis.

    Science.gov (United States)

    Löhr, J-Matthias; Haas, Stephen L; Lindgren, Fredrik; Enochsson, Lars; Hedström, Aleksandra; Swahn, Fredrik; Segersvärd, Ralf; Arnelo, Urban

    2013-01-01

    Chronic pancreatitis is a progressive inflammatory disease giving rise to several complications that need to be treated accordingly. Because pancreatic surgery has significant morbidity and mortality, less invasive therapy seems to be an attractive option. This paper reviews current state-of-the-art strategies to treat chronic pancreatitis without surgery and the current guidelines for the medical therapy of chronic pancreatitis. Endoscopic therapy of complications of chronic pancreatitis such as pain, main pancreatic duct strictures and stones as well as pseudocysts is technically feasible and safe. The long-term outcome, however, is inferior to definitive surgical procedures such as resection or drainage. On the other hand, the medical therapy of pancreatic endocrine and exocrine insufficiency is well established and evidence based. Endoscopic therapy may be an option to bridge for surgery and in children/young adolescents and those unfit for surgery. Pain in chronic pancreatitis as well as treatment of pancreatic exocrine insufficiency follows established guidelines. Copyright © 2013 S. Karger AG, Basel.

  7. Pharmacological challenges in chronic pancreatitis.

    Science.gov (United States)

    Olesen, Anne Estrup; Brokjaer, Anne; Fisher, Iben Wendelboe; Larsen, Isabelle Myriam

    2013-11-14

    Drug absorption in patients with chronic pancreatitis might be affected by the pathophysiology of the disease. The exocrine pancreatic insufficiency is associated with changes in gastrointestinal intraluminal pH, motility disorder, bacterial overgrowth and changed pancreatic gland secretion. Together these factors can result in malabsorption and may also affect the efficacy of pharmacological intervention. The lifestyle of chronic pancreatitis patients may also contribute to gastrointestinal changes. Many patients limit their food intake because of the pain caused by eating and in some cases food intake is more or less substituted with alcohol, tobacco and coffee. Alcohol and drug interaction are known to influence the pharmacokinetics by altering either drug absorption or by affecting liver metabolism. Since patients suffering from chronic pancreatitis experience severe pain, opioids are often prescribed as pain treatment. Opioids have intrinsic effects on gastrointestinal motility and hence can modify the absorption of other drugs taken at the same time. Furthermore, the increased fluid absorption caused by opioids will decrease water available for drug dissolution and may hereby affect absorption of the drug. As stated above many factors can influence drug absorption and metabolism in patients with chronic pancreatitis. The factors may not have clinical relevance, but may explain inter-individual variations in responses to a given drug, in patients with chronic pancreatitis.

  8. Chronic Pain, Chronic Opioid Addiction: a Complex Nexus.

    Science.gov (United States)

    Salsitz, Edwin A

    2016-03-01

    Over the past two decades, there has been a significant increase in the prescribing of opioids, with associated increases in opioid addiction and overdose deaths. This article reviews the evidence for the effectiveness and risk of developing an opioid use disorder (OUD) in those patients treated with chronic opioid therapy (COT) for chronic non-cancer pain (CNCP). Rates of development of OUD range from 0-50 %, and aberrant drug related behaviors (ADRBs) are reported to be 20 %. Health care providers must properly assess, screen, and carefully monitor patients on COT utilizing evidence-based tools.

  9. Angiotensin converting enzyme 1 in the median preoptic nucleus contributes to chronic intermittent hypoxia hypertension.

    Science.gov (United States)

    Faulk, Katelynn E; Nedungadi, T Prashant; Cunningham, J Thomas

    2017-05-01

    Obstructive sleep apnea is associated with hypertension and cardiovascular disease. Chronic intermittent hypoxia is used to model the arterial hypoxemia seen in sleep apnea patients and is associated with increased sympathetic nerve activity and a sustained diurnal increase in blood pressure. The renin angiotensin system has been associated with hypertension seen in chronic intermittent hypoxia. Angiotensin converting enzyme 1, which cleaves angiotensin I to the active counterpart angiotensin II, is present within the central nervous system and has been shown to be regulated by AP-1 transcription factors, such as ΔFosB. Our previous study suggested that this transcriptional regulation in the median preoptic nucleus contributes to the sustained blood pressure seen following chronic intermittent hypoxia. Viral mediated delivery of a short hairpin RNA against angiotensin converting enzyme 1 in the median preoptic nucleus was used along with radio-telemetry measurements of blood pressure to test this hypothesis. FosB immunohistochemistry was utilized in order to assess the effects of angiotensin converting enzyme 1 knockdown on the activity of nuclei downstream from median preoptic nucleus. Angiotensin converting enzyme 1 knockdown within median preoptic nucleus significantly attenuated the sustained hypertension seen in chronic intermittent hypoxia. Angiotensin converting enzyme 1 seems to be partly responsible for regulating downstream regions involved in sympathetic and blood pressure control, such as the paraventricular nucleus and the rostral ventrolateral medulla. The data suggest that angiotensin converting enzyme 1 within median preoptic nucleus plays a critical role in the sustained hypertension seen in chronic intermittent hypoxia. © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

  10. Labelling chronic illness in primary care: a good or a bad thing?

    Science.gov (United States)

    Bedson, John; McCarney, Rob; Croft, Peter

    2004-12-01

    Traditionally the management of any chronic condition starts with its diagnosis. The labelling of disease can be beneficial in terms of defining appropriate treatment such as in coronary artery disease. However, sometimes it may be detrimental such as when x-rays are used to diagnose lumbar spondylosis leading to patients inappropriately limiting their activity. Chronic knee pain in the elderly is another example where applying labels is problematical. A common diagnosis in this situation is osteoarthritis, but this label can be applied in two ways: as a radiological diagnosis, or as a clinical one. The x-ray diagnosis, however, does not equate with the clinical syndrome, and vice versa. In addition, diagnosing knee pain as osteoarthritis does not necessarily help in management, since a patient's debility is more dependent upon their clinical signs and symptoms than the presence of radiographic osteoarthritis, and by the same token its clinical counterpart. GPs are consistent in their management of knee pain, but in attempting to diagnose the pain as osteoarthritis, these plans can alter and become more dependent on the actual diagnosis than the clinical picture. As a result management may well diverge from what the current best evidence supports. Diagnosis for diagnosis sake, should therefore be discouraged, and chronic knee pain gives us one example of why this is the case. GPs would be better placed to manage this condition if it was considered more as a regional pain syndrome, perhaps defining it simply as 'chronic knee pain in older people'. This example suggests that there is a pressing need in primary care to carefully consider in chronic disease when it is appropriate to be definitive in diagnosis such that when using disease specific labels, there is definite benefit for the patient and doctor.

  11. Self-esteem in adolescents with chronic physical illness vs. controls in Northern Russia.

    Science.gov (United States)

    Zashikhina, Anna; Hagglof, Bruno

    2014-01-01

    This work aims to study self-esteem in adolescents with diabetes, asthma and epilepsy; compare the results with those of the representative sample of healthy adolescents; and evaluate the predictive value of certain demographic, family-related, and disease-related factors on self-esteem. A total of 148 chronically ill adolescents and 301 matched healthy counterparts completed the Rosenberg Self Esteem Scale and the "I think I am" questionnaire. Adolescents' parents answered socio-economic status questions. Disease severity was evaluated by doctors of the outpatient clinic. Comparison analysis of the three disease groups revealed highest self-esteem perception in adolescents with diabetes, and lowest in adolescents with epilepsy. Unexpectedly, adolescents with diabetes scored higher than their healthy counterparts. There were no significant differences between the reports of adolescents with asthma and controls. In the epilepsy group, self-esteem was predicted mostly by disease severity and socio-economic status in diabetes and asthma groups, as well as by age and gender. The maintenance of positive self-esteem in adolescents with diabetes and asthma is a very reassuring finding. The other results of our study provide support for recognizing adolescents with epilepsy as a vulnerable group in the society. A multidisciplinary professional approach targeted on adolescents with epilepsy is needed, with focus on factors connected with maturation and gender issues.

  12. Pain Intensity Moderates the Relationship Between Age and Pain Interference in Chronic Orofacial Pain Patients.

    Science.gov (United States)

    Boggero, Ian A; Geiger, Paul J; Segerstrom, Suzanne C; Carlson, Charles R

    2015-01-01

    BACKGROUND/STUDY CONTEXT: Chronic pain is associated with increased interference in daily functioning that becomes more pronounced as pain intensity increases. Based on previous research showing that older adults maintain well-being in the face of pain as well as or better than their younger counterparts, the current study examined the interaction of age and pain intensity on interference in a sample of chronic orofacial pain patients. Data were obtained from the records of 508 chronic orofacial pain patients being seen for an initial evaluation from 2008 to 2012. Collected data included age (range: 18-78) and self-reported measures of pain intensity and pain interference. Bivariate correlations and regression models were used to assess for statistical interactions. Regression analyses revealed that pain intensity positively predicted pain interference (R(2) = .35, B = 10.40, SE = 0.62, t(507) = 16.70, p theories, including socioemotional selectivity theory, which posits that as people age, they become more motivated to maximize positive emotions and minimize negative ones. The results highlight the importance of studying the mechanisms older adults use to successfully cope with pain.

  13. Facial emotion recognition in Chinese with schizophrenia at early and chronic stages of illness.

    Science.gov (United States)

    Leung, Joey Shuk-Yan; Lee, Tatia M C; Lee, Chi-Chiu

    2011-12-30

    Deficits in facial emotion recognition have been recognised in Chinese patients diagnosed with schizophrenia. This study examined the relationship between chronicity of illness and performance of facial emotion recognition in Chinese with schizophrenia. There were altogether four groups of subjects matched for age and gender composition. The first and second groups comprised medically stable outpatients with first-episode schizophrenia (n=50) and their healthy controls (n=26). The third and fourth groups were patients with chronic schizophrenic illness (n=51) and their controls (n=28). The ability to recognise the six prototypical facial emotions was examined using locally validated coloured photographs from the Japanese and Caucasian Facial Expressions of Emotion. Chinese patients with schizophrenia, in both the first-episode and chronic stages, performed significantly worse than their control counterparts on overall facial emotion recognition, (Pemotion did not appear to have worsened over the course of disease progression, suggesting that recognition of facial emotion is a rather stable trait of the illness. The emotion-specific deficit may have implications for understanding the social difficulties in schizophrenia. Copyright © 2011 Elsevier Ltd. All rights reserved.

  14. The Role of Hope for Adolescents with a Chronic Illness: An Integrative Review.

    Science.gov (United States)

    Griggs, Stephanie; Walker, Rachel K

    2016-01-01

    Hope is a human strength essential for adolescents' enduring and coping with chronic illness however, the role of hope is not well understood in this population. This integrative review describes what is currently known about the role of hope in adolescents with a chronic illness. A methodological review using an integrative approach by R. Whittemore and K. Knafl (2005) was performed. MEDLINE via Pubmed; CINAHL; PyscINFO and Google scholar were searched for articles published in peer-reviewed journals from 1995 to 2015, using search terms 'hope and chronic illness' with age limiters for all except Google scholar (title search of "hope and adolescents"). Of the 197 studies initially retrieved: a total of 27 quantitative studies, 8 qualitative studies and 19 theoretical works were selected for review. Seven themes emerged including that hope: (i) promotes health (ii) facilitates coping and adjustment, (iii) enhances quality of life, (iv) is essential in purpose in life and illness (v) improves self-esteem, (vi) is an important factor in resilience and (vii) affects maturation. Persons reporting higher levels of hope find multiple routes to goals, view setbacks as challenges, and better manage psychological symptoms. Although theory and a limited body of empirical research to date suggest a link between hopeful thinking and physical health, the specific mechanisms remain unclear. As hope is linked to resilience, further research should explore whether adolescents with higher hope return to baseline faster than their lower hope counterparts. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. Are There Any Natural Remedies That Reduce Chronic Fatigue Associated with Chronic Fatigue Syndrome?

    Science.gov (United States)

    ... natural remedies that reduce chronic fatigue associated with chronic fatigue syndrome? Answers from Brent A. Bauer, M.D. Researchers ... a variety of natural products for effectiveness against chronic fatigue syndrome. Most results have been disappointing. A few remedies — ...

  16. Pharmacological challenges in chronic pancreatitis

    DEFF Research Database (Denmark)

    Olesen, Anne Estrup; Brokjaer, Anne; Fischer, Iben Wendelboe Deleuran

    2014-01-01

    food intake is more or less substituted with alcohol, tobacco and coffee. Alcohol and drug interaction are known to influence the pharmacokinetics by altering either drug absorption or by affecting liver metabolism. Since patients suffering from chronic pancreatitis experience severe pain, opioids......Drug absorption in patients with chronic pancreatitis might be affected by the pathophysiology of the disease. The exocrine pancreatic insufficiency is associated with changes in gastrointestinal intraluminal pH, motility disorder, bacterial overgrowth and changed pancreatic gland secretion....... Together these factors can result in malabsorption and may also affect the efficacy of pharmacological intervention. The lifestyle of chronic pancreatitis patients may also contribute to gastrointestinal changes. Many patients limit their food intake because of the pain caused by eating and in some cases...

  17. Chronic diseases in elderly men

    DEFF Research Database (Denmark)

    Nielsen, Morten Frost Munk; Wraae, Kristian; Gudex, Claire

    2012-01-01

    OBJECTIVE: prevalence estimates for chronic diseases and associated risk factors are needed for priority setting and disease prevention strategies. The aim of this cross-sectional study was to estimate the self-reported and clinical prevalence of common chronic disorders in elderly men. STUDY......-reported data on risk factors and disease prevalence were compared with data from hospital medical records. RESULTS: physical inactivity, smoking and excessive alcohol intake were reported by 27, 22 and 17% of the study population, respectively. Except for diabetes, all the chronic diseases investigated......, including hypertension, musculoskeletal and respiratory diseases were underreported by study participants. Erectile dysfunction and hypogonadism were substantially underreported in the study population even though these diseases were found to affect 48 and 21% of the participants, respectively. CONCLUSIONS...

  18. Pharmacological challenges in chronic pancreatitis

    DEFF Research Database (Denmark)

    Olesen, Anne Estrup; Brokjaer, Anne; Fischer, Iben Wendelboe Deleuran

    2014-01-01

    food intake is more or less substituted with alcohol, tobacco and coffee. Alcohol and drug interaction are known to influence the pharmacokinetics by altering either drug absorption or by affecting liver metabolism. Since patients suffering from chronic pancreatitis experience severe pain, opioids....... Together these factors can result in malabsorption and may also affect the efficacy of pharmacological intervention. The lifestyle of chronic pancreatitis patients may also contribute to gastrointestinal changes. Many patients limit their food intake because of the pain caused by eating and in some cases......Drug absorption in patients with chronic pancreatitis might be affected by the pathophysiology of the disease. The exocrine pancreatic insufficiency is associated with changes in gastrointestinal intraluminal pH, motility disorder, bacterial overgrowth and changed pancreatic gland secretion...

  19. Aminoadamantanes for chronic hepatitis C

    DEFF Research Database (Denmark)

    Lamers, Mieke H; Broekman, Mark; Drenth, Joost Ph

    2014-01-01

    BACKGROUND: Around 3% of the world's population (approximately 160 million people) are chronically infected with hepatitis C virus. The proportion of infected people who develop clinical symptoms varies between 5% and 40%. Combination therapy with pegylated interferon-alpha plus ribavirin...... response in genotype 1 infected patients to at least 70%. There is therefore an unmet need for drugs that can achieve a higher proportion of sustained virological response. Aminoadamantanes are antiviral drugs used for treatment of patients with chronic hepatitis C. OBJECTIVES: To assess the beneficial...... and harmful effects of aminoadamantanes for patients with chronic hepatitis C infection by conducting a systematic review with meta-analyses of randomised clinical trials, as well as trial sequential analyses. SEARCH METHODS: We conducted electronic searches of the Cochrane Hepato-Biliary Group Controlled...

  20. Microvascular pressure responses of second-generation rats chronically exposed to 2 g centrifugation

    Science.gov (United States)

    Richardson, D. R.; Knapp, C. F.

    1977-01-01

    Preliminary results are presented for a study aimed at a quantitative comparison of microvascular dynamics in second-generation rats reared in a 2-g force field produced by centrifugation with similar data from animals reared in a centrifuge that produced only a 1-g force. It is shown that the pressure distribution in the mesenteric microvasculature of the second generation of rats reared in a 2-g environment, as well as the animals' blood pressure response to epinephrine, are significantly different compared to their 1-g counterparts. In particular, 1-g and 2-g chronic centrifugation enhances the arterial blood pressure, and the 2-g force field attenuates the pressor effects of norepinephrine.

  1. Chronic Pancreatitis: A Changing Etiology?

    OpenAIRE

    Raffaele Pezzilli; Andrea Lioce; Luca Frulloni

    2008-01-01

    In 1998, Lankisch and Banks reported that the prevalence of chronic pancreatitis appeared to be in the range of 3-10 per 100,000 people in many parts of the world [1]. They also emphasized that the most important medical problems associated with the disease included abdominal pain, steatorrhea, diabetes mellitus and the possibility that chronic pancreatitis may be considered a premalignant condition [2, 3]. In 2002, in a well-written review, Banks pointed out that the two important forms were...

  2. The chronic exposure case

    International Nuclear Information System (INIS)

    Barescut, Jean-Claude

    2006-01-01

    will not have the same effect if it is added to one set of cofactors or to another one. This is critical in order to perform a global risk management. There are some signs that the management of radioactive risk is at a turn today. ICRP is about to issue new recommendations and wishes to include biota protection. Some dissident scientists are emitting reserves concerning risk evaluation and lastly, the non nuclear world is rapidly evolving toward a more cautious control (REACH European directive) of chemicals suspected to impact man or environmental health. The paper has the following contents: Some technical points to address; Chronic versus acute exposure; Long versus short life radionuclides; Homogeneity versus inhomogeneity; Combined stresses; How to tackle the problem; What extent of the dose concept; Contribution of epidemiology; Contribution of molecular and fundamental biology of low level systems; Ecological point a view; In situ and laboratory radioecology; IRSN researches; A few deviations to linearity; A real population effect; Effect of 241 Am on daphnia magna. The examples given above are only a part of researches currently done at the IRSN. Many other researches, either in ENVIRHOM or closely related fields, are ongoing: performance of central nervous system, intestinal transfer, experiments on soil aging, in situ experiments on Chernobyl contaminated soils, experiments with other radionuclides (Se, Tc, Co, etc). This review is based upon the ENVIRHOM research program supported by the Institute for Radioprotection and Nuclear Safety

  3. Isoperiodic classical systems and their quantum counterparts

    International Nuclear Information System (INIS)

    Asorey, M.; Carinena, J.F.; Marmo, G.; Perelomov, A.

    2007-01-01

    One-dimensional isoperiodic classical systems have been first analyzed by Abel. Abel's characterization can be extended for singular potentials and potentials which are not defined on the whole real line. The standard shear equivalence of isoperiodic potentials can also be extended by using reflection and inversion transformations. We provide a full characterization of isoperiodic rational potentials showing that they are connected by translations, reflections or Joukowski transformations. Upon quantization many of these isoperiodic systems fail to exhibit identical quantum energy spectra. This anomaly occurs at order O(h 2 ) because semiclassical corrections of energy levels of order O(h) are identical for all isoperiodic systems. We analyze families of systems where this quantum anomaly occurs and some special systems where the spectral identity is preserved by quantization. Conversely, we point out the existence of isospectral quantum systems which do not correspond to isoperiodic classical systems

  4. Chronic bacterial prostatitis and chronic pelvic pain syndrome.

    Science.gov (United States)

    Bowen, Diana K; Dielubanza, Elodi; Schaeffer, Anthony J

    2015-08-27

    Chronic prostatitis can cause pain and urinary symptoms, and can occur either with an active infection (chronic bacterial prostatitis [CBP]) or with only pain and no evidence of bacterial causation (chronic pelvic pain syndrome [CPPS]). Bacterial prostatitis is characterised by recurrent urinary tract infections or infection in the prostate with the same bacterial strain, which often results from urinary tract instrumentation. However, the cause and natural history of CPPS are unknown and not associated with active infection. We conducted a systematic overview and aimed to answer the following clinical questions: What are the effects of treatments for chronic bacterial prostatitis? What are the effects of treatments for chronic pelvic pain syndrome? We searched: Medline, Embase, The Cochrane Library, and other important databases up to February 2014 (Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview). At this update, searching of electronic databases retrieved 131 studies. After deduplication and removal of conference abstracts, 67 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 51 studies and the further review of 16 full publications. Of the 16 full articles evaluated, three systematic reviews and one RCT were included at this update. We performed a GRADE evaluation for 14 PICO combinations. In this systematic overview, we categorised the efficacy for 12 interventions based on information relating to the effectiveness and safety of 5 alpha-reductase inhibitors, allopurinol, alpha-blockers, local injections of antimicrobial drugs, mepartricin, non-steroidal anti-inflammatory drugs (NSAIDs), oral antimicrobial drugs, pentosan polysulfate, quercetin, sitz baths, transurethral microwave thermotherapy (TUMT), and transurethral resection of the prostate (TURP).

  5. The Electromagnetic Counterpart of the Binary Neutron Star Merger LIGO/Virgo GW170817. VI. Radio Constraints on a Relativistic Jet and Predictions for Late-time Emission from the Kilonova Ejecta

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, K. D.; Berger, E.; Fong, W.; Williams, P. K. G.; Guidorzi, C.; Margutti, R.; Metzger, B. D.; Annis, J.; Blanchard, P. K.; Brout, D.; Brown, D. A.; Chen, H. -Y.; Chornock, R.; Cowperthwaite, P. S.; Drout, M.; Eftekhari, T.; Frieman, J.; Holz, D. E.; Nicholl, M.; Rest, A.; Sako, M.; Soares-Santos, M.; Villar, V. A.

    2017-10-16

    We present Very Large Array (VLA) and Atacama Large Millimeter/sub-millimeter Array ALMA radio observations of GW\\,170817, the first Laser Interferometer Gravitational-wave Observatory (LIGO)/Virgo gravitational wave (GW) event from a binary neutron star merger and the first GW event with an electromagnetic (EM) counterpart. Our data include the first observations following the discovery of the optical transient at both the centimeter ($13.7$ hours post merger) and millimeter ($2.41$ days post merger) bands. We detect faint emission at 6 GHz at 19.47 and 39.23 days after the merger, but not in an earlier observation at 2.46 d. We do not detect cm/mm emission at the position of the optical counterpart at frequencies of 10-97.5 GHz at times ranging from 0.6 to 30 days post merger, ruling out an on-axis short gamma-ray burst (SGRB) for energies $\\gtrsim 10^{48}$ erg. For fiducial SGRB parameters, our limits require an observer viewer angle of $\\gtrsim 20^{\\circ}$. The radio and X-ray data can be jointly explained as the afterglow emission from an SGRB with a jet energy of $\\sim 10^{49}-10^{50}$ erg that exploded in a uniform density environment with $n\\sim 10^{-4}-10^{-2}$ cm$^{-3}$, viewed at an angle of $\\sim 20^{\\circ}-40^{\\circ}$ from the jet axis. Using the results of our light curve and spectral modeling, in conjunction with the inference of the circumbinary density, we predict the emergence of late-time radio emission from the deceleration of the kilonova (KN) ejecta on a timescale of $\\sim 5-10$ years that will remain detectable for decades with next-generation radio facilities, making GW\\,170817 a compelling target for long-term radio monitoring.

  6. [Chronic diarrhea with uncommon etiology].

    Science.gov (United States)

    Gil Borrás, R; Juan Vidal, O; Talavera Encinas, M I; Bixquert Jiménez, M

    2005-03-01

    Chronic diarrhea is a common syndrome. An etiological diagnosis is often reached through clinical history, physical examination and simple tests. In some cases, when the etiology is not found, the syndrome is called functional diarrhea, even though established criteria are often not fulfilled. We present the case of a patient with diarrhea for several months. The most common causes were ruled out through clinical history, physical examination, radiographic studies and laboratory tests, and the patient was diagnosed with functional diarrhea. Three months later, the patient presented a neck mass, and biopsy revealed medullary carcinoma of the thyroid. A review of recommendations for the systematic evaluation of chronic diarrhea is presented. A general approach should include careful history taking characteristics of diarrhea (onset, associated symptoms, epidemiological factors, iatrogenic causes such as laxative ingestion), a thorough physical examination with special attention to the anorectal region, and routine laboratory tests (complete blood count and serum chemistry). In addition, stool analysis including electrolytes (fecal osmotic gap), leukocytes, fecal occult blood, excess stool fat and laxative screening can yield important objective information to classify the diarrhea as: osmotic (osmotic gaps > 125 mOsm/Kg), secretory (osmotic gaps diarrhea described above. A systematic approach to the evaluation of chronic diarrhea is warranted. Medullary thyroid carcinoma and other endocrine syndromes causing chronic diarrhea are very rare. Measurement of serum peptide concentrations should only be performed when clinical presentation and findings in stool or radiographic studies suggest this etiology.

  7. Working with Chronically Dysfunctional Families.

    Science.gov (United States)

    Younger, Robert; And Others

    This paper reviews family therapy with chronically dysfunctional families including the development of family therapy and current trends which appear to give little guidance toward working with severely dysfunctional families. A theoretical stance based upon the systems approach to family functioning and pathology is presented which suggests: (1)…

  8. Genetic aspects of chronic pancreatitis.

    NARCIS (Netherlands)

    Verlaan, M.

    2005-01-01

    Chronic pancreatitis (CP) is a progressive inflammatory disorder. A key characteristic of the condition is severe recurrent abdominal pain. The origin of CP is mixed, with about 70% of the cases being attributed to alcohol abuse even though 95% of all alcoholics never develop CP. Approximately half

  9. Referent Communication in Chronic Schizophrenia

    Science.gov (United States)

    Kantorowitz, David A.; Cohen, Bertram D.

    1977-01-01

    Thirty chronic schizophrenics (15 process and 15 reactive) and 15 normal control speakers described colors displayed in three-chip sets containing a referent and two nonreferent colors. Concludes that poor communication accuracy in long-term schizophrenics results from failure to include a self-editing stage as a part of the communication process.…

  10. Malignant transformation in chronic osteomyelitis

    Directory of Open Access Journals (Sweden)

    Diogo Lino Moura

    Full Text Available ABSTRACT INTRODUCTION: Carcinomatous degeneration is a rare and late complication developing decades after the diagnosis of chronic osteomyelitis. OBJECTIVES: To present the results from a retrospective study of six cases of squamous cell carcinoma arising from chronic osteomyelitis. METHODS: Six cases of chronic osteomyelitis related to cutaneous squamous cell carcinoma were identified. The cause and characteristics of the osteomyelitis were analyzed, as well as time up to malignancy, the suspicion signs for malignancy, the localization and histological type of the cancer, and the type and result of the treatment. RESULTS: The mean time between osteomyelitis onset and the diagnosis of malignant degeneration was 49.17 years (range: 32-65. The carcinoma resulted from tibia osteomyelitis in five cases and from femur osteomyelitis in one. The pathological examination indicated cutaneous squamous cell carcinoma in all cases. All the patients were staged as N0M0, except for one, whose lomboaortic lymph nodes were affected. The treatment consisted of amputation proximal to the tumor in all patients. No patient presented signs of local recurrence and only one had carcinoma metastasis. CONCLUSION: Early diagnosis and proximal amputation are essential for prognosis and final results in carcinomatous degeneration secondary to chronic osteomyelitis.

  11. Chronic Venous Disease under pressure

    NARCIS (Netherlands)

    S.W.I. Reeder (Suzan)

    2013-01-01

    textabstractIn chapter 1 we provide a general introduction of this thesis. Chronic venous disease (CVD) is a common medical condition that affects 2-64% of the worldwide population and leads to leg ulcers in 1% of the Western population. Venous leg ulceration (VLU) has an unfavorable prognosis with

  12. Aminoadamantanes for chronic hepatitis C

    NARCIS (Netherlands)

    Lamers, M.H.; Broekman, M.; Drenth, J.P.H.; Gluud, C.

    2014-01-01

    BACKGROUND: Around 3% of the world's population (approximately 160 million people) are chronically infected with hepatitis C virus. The proportion of infected people who develop clinical symptoms varies between 5% and 40%. Combination therapy with pegylated interferon-alpha plus ribavirin eradicates

  13. Biofeedback training in chronic constipation

    NARCIS (Netherlands)

    Benninga, M. A.; Büller, H. A.; Taminiau, J. A.

    1993-01-01

    Twenty nine patients, aged 5-16 years, were studied to evaluate whether biofeedback training is effective in treating children with chronic constipation and encopresis; the clinical outcome at six weeks and 12 months was also evaluated. Patients received on average five biofeedback training

  14. Metformin in chronic kidney disease

    DEFF Research Database (Denmark)

    Heaf, James

    2014-01-01

    Metformin has traditionally been regarded as contraindicated in chronic kidney disease (CKD), though guidelines in recent years have been relaxed to permit therapy if the glomerular filtration rate (GFR) is > 30 mL/min. The main problem is the perceived risk of lactic acidosis (LA). Epidemiological...

  15. [Chronic prostatitis and Bechterew's disease].

    Science.gov (United States)

    Kohlicek, J; Svec, V

    1977-11-01

    A group of patients between 35 and 65 years old with chronic prostatitis were examined for the presence of Becherew's disease. In this connection the New York and Roman criterions for morbus Bechterew were applied. There were found one ankyosing spondylarthritis, one ankylosis of the sacroiliac joint, and 11 times a tentative sacroileitis were stated. Altogether the proved and tentative findings were only 3.68 per cent of all examinations. In our countries the morbus Bechterew is found in 0,21 per cent of the normal population. So the protion of the Bechterew's disease in patients with chronic prostatitis is indeed a little higher than average, but not so frequent as often pretended in recent times. After a second series 58 patients being treated because of Bechterew's disease of different stages and different terms were examined for the possibility of a simultaneously elapsing chronic prostatitis. A chronic prostatitis was found in 38 per cent of these patients which correspondents to the incidence published in literature for the medium-age manhood. Nobody of the test persons had complaints on the part of the urologenital tract.

  16. Gene polymorphisms in chronic periodontitis

    NARCIS (Netherlands)

    Laine, M.L.; Loos, B.G.; Crielaard, W.

    2010-01-01

    We aimed to conduct a review of the literature for gene polymorphisms associated with chronic periodontitis (CP) susceptibility. A comprehensive search of the literature in English was performed using the keywords: periodontitis, periodontal disease, combined with the words genes, mutation, or

  17. Enteric hyperoxaluria in chronic pancreatitis.

    Science.gov (United States)

    Demoulin, Nathalie; Issa, Zaina; Crott, Ralph; Morelle, Johann; Danse, Etienne; Wallemacq, Pierre; Jadoul, Michel; Deprez, Pierre H

    2017-05-01

    Chronic pancreatitis may lead to steatorrhea, enteric hyperoxaluria, and kidney damage. However, the prevalence and determinants of hyperoxaluria in chronic pancreatitis patients as well as its association with renal function decline have not been investigated.We performed an observational study. Urine oxalate to creatinine ratio was assessed on 2 independent random urine samples in consecutive adult patients with chronic pancreatitis followed at the outpatient clinic from March 1 to October 31, 2012. Baseline characteristics and annual estimated glomerular filtration rate (eGFR) change during follow-up were compared between patients with hyper- and normo-oxaluria.A total of 48 patients with chronic pancreatitis were included. The etiology of the disease was toxic (52%), idiopathic (27%), obstructive (11%), autoimmune (6%), or genetic (4%). Hyperoxaluria (defined as urine oxalate to creatinine ratio >32 mg/g) was found in 23% of patients. Multivariate regression analysis identified clinical steatorrhea, high fecal acid steatocrit, and pancreatic atrophy as independent predictors of hyperoxaluria. Taken together, a combination of clinical steatorrhea, steatocrit level >31%, and pancreatic atrophy was associated with a positive predictive value of 100% for hyperoxaluria. On the contrary, none of the patients with a fecal elastase-1 level >100 μg/g had hyperoxaluria. Longitudinal evolution of eGFR was available in 71% of the patients, with a mean follow-up of 904 days. After adjustment for established determinants of renal function decline (gender, diabetes, bicarbonate level, baseline eGFR, and proteinuria), a urine oxalate to creatinine ratio >32 mg/g was associated with a higher risk of eGFR decline.Hyperoxaluria is highly prevalent in patients with chronic pancreatitis and associated with faster decline in renal function. A high urine oxalate to creatinine ratio in patients with chronic pancreatitis is best predicted by clinical steatorrhea, a high acid

  18. Medication Overuse in Chronic Pain.

    Science.gov (United States)

    Hsu, Eric S

    2017-01-01

    Chronic pain is usually managed by various pharmacotherapies after exhausting the conservative modalities such as over-the-counter choices. The goal of this review is to investigate current state of opioids and non-opioid medication overuse that includes NSAIDs, skeletal muscle relaxants, antidepressants, membrane stabilization agents, and benzodiazepine. How to minimize medication overuse and achieve better outcome in chronic pain management? Although antidepressants and membrane stabilization agents contribute to the crucial components for neuromodulation, opioids were frequently designated as a rescue remedy in chronic pain since adjunct analgesics usually do not provide instantaneous relief. The updated CDC guideline for prescribing opioids has gained widespread attention via media exposure. Both patients and prescribers are alerted to respond to the opioid epidemic and numerous complications. However, there has been overuse of non-opioid adjunct analgesics that caused significant adverse effects in addition to concurrent opioid consumption. It is a common practice to extrapolate the WHO three-step analgesic ladder for cancer pain to apply in non-cancer pain that emphasizes solely on pharmacologic therapy which may result in overuse and escalation of opioids in non-cancer pain. There has been promising progress in non-pharmacologic therapies such as biofeedback, complementary, and alternative medicine to facilitate pain control instead of dependency on pharmacologic therapies. This review article presents the current state of medication overuse in chronic pain and proposes precaution to balance the risk and benefit ratio. It may serve as a premier for future study on clinical pathway for comprehensive chronic pain management and reduce medication overuse.

  19. Pathogenesis of chronic subdural hematoma

    International Nuclear Information System (INIS)

    Taguchi, Yoshio; Nakamura, Norio; Sato, Jun; Hasegawa, Yoshio.

    1982-01-01

    Ten cases of chronic subdural hematoma that were followed by a sequential study with CT from an early posttraumatic period to evolution of chronic subdural hematoma were reported. In four of these 10 cases, the initial CT showed thin subdural collections of high density suggesting acute subdural hematoma. Two weeks later, the density of subdural collections reduced, but their volumes increased. Clinical symptoms such as headache and disorientation occurred three or four weeks later. Preoperative CT showed similar huge subdural collections of low density and marked mass effect. These cases underwent surgery from 24 to 44 days after injury, and development of neomenbranes was confirmed. In the remaining six cases, the initial CT showed thin subdural collections of low density suggesting subdural hygroma. In five of the six cases, the density of the subdural collections was slightly higher than that of cerebrospinal fluid, and in one case, an area of spotted high density was shown. It was suggested that these were mixtures with blood. Follow-up CT scans revealed that the subdural collections increased in size but remained at a uniformly low density for the first month after the head injury, and then the increase in density occurred. Operations were performed 55 to 76 days after injury, and operative findings were not different from those of common chronic subdural hematoma. From these investigations, it was suggested that there were two types of evolution of chronic subdural hematoma. One is the development from acute subdural hematomas, and the other from subdural hygromas. It is supposed that blood and cerebrospinal fluid are very important factors in the evolution of subdural collections into chronic subdural hematomas. (J.P.N.)

  20. Chronic Condition Public Use File (PUF)

    Data.gov (United States)

    U.S. Department of Health & Human Services — This release contains the Chronic Conditions Public Use Files (PUF) with information from Medicare claims. The CMS Chronic Conditions PUF is an aggregated file in...

  1. Pregabalin for Pain Treatment in Chronic Pancreatitis

    DEFF Research Database (Denmark)

    Olesen, Søren Schou; Bowense, S; Wilder-Smith, Oliver

    2011-01-01

    Intractable pain usually dominates the clinical presentation of chronic pancreatitis (CP). Slowing of electroencephalogram (EEG) rhythmicity has been associated with abnormal cortical pain processing in other chronic pain disorders. The aim of this study was to investigate the spectral distribution...

  2. Chronic obstructive pulmonary disease - adults - discharge

    Science.gov (United States)

    ... coughing up dark mucus Your fingertips or the skin around your fingernails are blue Alternative Names COPD - adults - discharge; Chronic obstructive airways disease - adults - discharge; Chronic obstructive lung disease - adults - discharge; ...

  3. Neurological Complications Of Chronic Myeloid Leukaemia: Any ...

    African Journals Online (AJOL)

    , of the neurological deficits complicating chronic myeloid leukaemia. Method: Using patients\\' case folders and haematological malignancy register all cases of chronic myeloid leukaemia seen in Jos University Teaching Hospital between July ...

  4. How Is Chronic Myeloid Leukemia Diagnosed?

    Science.gov (United States)

    ... Myeloid Leukemia? More In Chronic Myeloid Leukemia About Chronic Myeloid Leukemia Causes, Risk Factors, and Prevention Early Detection, Diagnosis, and Staging Treatment After Treatment Back To Top Imagine a world ...

  5. Drug therapy for chronic idiopathic axonal polyneuropathy

    NARCIS (Netherlands)

    Vrancken, A. F. J. E.; van Schaik, I. N.; Hughes, R. A. C.; Notermans, N. C.

    2004-01-01

    BACKGROUND: Chronic idiopathic axonal polyneuropathy is an insidiously progressive sensory or sensorimotor polyneuropathy that affects elderly people. Although severe disability or handicap does not occur, it reduces quality of life. OBJECTIVES: To assess whether drug therapy for chronic idiopathic

  6. Global strategies to prevent chronic diseases1

    African Journals Online (AJOL)

    Nicky

    leading global causes of death and disability, are ... global strategies for the prevention and control of chronic ... Preventing Chronic Diseases: A Vital Investment, will ..... Millennium Development Goals for Health In Europe and Central Asia.

  7. Chronic Fatigue Syndrome: Review of the Literature

    OpenAIRE

    Turgeon, Sue A.

    1989-01-01

    Chronic fatigue syndrome, previously known as chronic mononucleosis or post-infectious fatigue, is a poorly understood illness characterized by chronic debilitating fatigue, recurrent flu-like symptoms, and few clinical or laboratory abnormalities. Attention was briefly focused on the Epstein-Barr virus (EBV) as a causal agent, but that hypothesis is now in serious doubt. While a significant incidence of psychiatric illness has been demonstrated among patients with the chronic fatigue syndrom...

  8. Chronic radiodermatitis. A historical and actual diagnosis

    International Nuclear Information System (INIS)

    Tilsted, D.; Norup Lauridsen, K.; Otkjaer Nielsen, A.

    1997-01-01

    Chronic radiodermatitis was already diagnosed a few years after the discovery of X-rays. Despite the fact that protection should be known to be necessary to avoid radiodermatitis, cases of chronic radiodermatitis still occur. The present case report describes a nurse who endured years of direct hand exposure, leading to chronic radiodermatitis ten years after cessation of exposure. (au) 10 refs

  9. Treatment for Chronic Depression Using Schema Therapy

    NARCIS (Netherlands)

    Renner, F.; Arntz, A.; Leeuw, I.; Huibers, M.J.H.

    2013-01-01

    Schema therapy (ST) is an integrative treatment approach to chronic lifelong problems with an established effectiveness for treating personality disorders. This article describes the adaptation of ST to chronic depression by reviewing the literature on the underlying risk factors to chronic

  10. Shared genetic factors underlie chronic pain syndromes

    NARCIS (Netherlands)

    Vehof, Jelle; Zavos, Helena M. S.; Lachance, Genevieve; Hammond, Christopher J.; Williams, Frances M. K.

    Chronic pain syndromes (CPS) are highly prevalent in the general population, and increasingly the evidence points to a common etiological pathway. Using a large cohort of twins (n = 8564) characterized for chronic widespread musculoskeletal pain (CWP), chronic pelvic pain (PP), migraine (MIG), dry

  11. Chinese medicinal herbs for chronic hepatitis B

    DEFF Research Database (Denmark)

    Liu, J; McIntosh, H; Lin, Haili

    2001-01-01

    Chronic hepatitis B is a serious health problem worldwide. Chinese medicinal herbs are widely used for treatment of chronic hepatitis B in China and many clinical trials have been conducted. This systematic review is to assess the efficacy and safety of Chinese medicinal herbs for chronic hepatitis...

  12. Attitudes and beliefs about chronic pain among nurses- biomedical or behavioral? A cross-sectional survey

    Directory of Open Access Journals (Sweden)

    Venkatesan Prem

    2011-01-01

    Full Text Available Context: Studies have documented that nurses and other health care professionals are inadequately prepared to care for patients in chronic pain. Several reasons have been identified including inadequacies in nursing education, absence of curriculum content related to pain management, and attitudes and beliefs related to chronic pain. Aims: The objective of this paper was to assess the chronic pain-related attitudes and beliefs among nursing professionals in order to evaluate the biomedical and behavioral dimensions of their perceptions on pain. Settings and Design: Cross-sectional survey of 363 nurses in a multispecialty hospital. Materials and Methods: The study utilized a self-report questionnaire - pain attitudes and beliefs scale (PABS - which had 31 items (statements about pain for each of which the person had to indicate the level at which he or she agreed or disagreed with each statement. Factor 1 score indicated a biomedical dimension while factor 2 score indicated a behavioral dimension to pain. Statistical Analysis Used: Comparisons across individual and professional variables for both dimensions were done using one-way ANOVA and correlations were done using the Karl-Pearson co-efficient using SPSS version 11.5 for Windows. Results: The overall factor 1 score was 52.95 ± 10.23 and factor 2 score was 20.93 ± 4.72 (P = 0.00. The female nurses had a higher behavioral dimension score (21.1 ± 4.81 than their male counterparts (19.55 ± 3.67 which was significant at P< 0.05 level. Conclusions: Nurses had a greater orientation toward the biomedical dimension of chronic pain than the behavioral dimension. This difference was more pronounced in female nurses and those nurses who reported "very good" general health had higher behavioral dimension scores than those who had "good" general health. The study findings have important curricular implications for nurses and practical implications in palliative care.

  13. Contemporary Management of Chronic Prostatitis/Chronic Pelvic Pain Syndrome.

    Science.gov (United States)

    Magistro, Giuseppe; Wagenlehner, Florian M E; Grabe, Magnus; Weidner, Wolfgang; Stief, Christian G; Nickel, J Curtis

    2016-02-01

    Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common condition that causes severe symptoms, bother, and quality-of-life impact in the 8.2% of men who are believed to be affected. Research suggests a complex pathophysiology underlying this syndrome that is mirrored by its heterogeneous clinical presentation. Management of patients diagnosed with CP/CPPS has always been a formidable task in clinical practice. Due to its enigmatic etiology, a plethora of clinical trials failed to identify an efficient monotherapy. A comprehensive review of published randomized controlled trials (RCTs) on the treatment of CP/CPPS and practical best evidence recommendations for management. Medline and the Cochrane database were screened for RCTs on the treatment of CP/CPPS from 1998 to December 2014, using the National Institutes of Health Chronic Prostatitis Symptom Index as an objective outcome measure. Published data in concert with expert opinion were used to formulate a practical best evidence statement for the management of CP/CPPS. Twenty-eight RCTs identified were eligible for this review and presented. Trials evaluating antibiotics, α-blockers, anti-inflammatory and immune-modulating substances, hormonal agents, phytotherapeutics, neuromodulatory drugs, agents that modify bladder function, and physical treatment options failed to reveal a clear therapeutic benefit. With its multifactorial pathophysiology and its various clinical presentations, the management of CP/CPPS demands a phenotypic-directed approach addressing the individual clinical profile of each patient. Different categorization algorithms have been proposed. First studies applying the UPOINTs classification system provided promising results. Introducing three index patients with CP/CPPS, we present practical best evidence recommendations for management. Our current understanding of the pathophysiology underlying CP/CPPS resulting in this highly variable syndrome does not speak in favor of a

  14. Vouchers for chronic disease care.

    Science.gov (United States)

    Watts, Jennifer J; Segal, Leonie

    2008-08-01

    This paper explores the economic implications of vouchers for chronic disease management with respect to achieving objectives of equity and efficiency. Vouchers as a payment policy instrument for health care services have a set of properties that suggest they may address both demand-side and supply-side issues, and contribute to equity and efficiency. They provide a means whereby health care services can be targeted at selected groups, enabling consumer choice of provider, and encouraging competition in the supply of health services. This analysis suggests that, when structured appropriately, vouchers can support consumers to choose services that will meet their health care needs and encourage competition among providers. Although they may not be appropriate across the entire health care system, there are features of vouchers that make them a potentially attractive option, especially for the management of chronic disease.

  15. Management of chronic visceral pain

    DEFF Research Database (Denmark)

    Olesen, Anne E; Farmer, Adam D; Olesen, Søren S

    2016-01-01

    Despite marked differences in underlying pathophysiology, the current management of visceral pain largely follows the guidelines derived from the somatic pain literature. The effective management of patients with chronic visceral pain should be multifaceted, including both pharmacological...... and psychological interventions, thereby providing a mechanism-orientated approach to treatment. Patients can frequently become disenfranchised, and subsequently disengaged, with healthcare providers leading to repeated consultations. Thus, a key aspect of management is to break this cycle by validating patients......' symptoms, adopting an empathic approach and taking time to educate patients. To optimize treatment and outcomes in chronic visceral pain we need to move away from approaches exclusively based on dealing with peripheral nociceptive input toward more holistic strategies, taking into account alterations...

  16. Insulin resistance and chronic inflammation

    Directory of Open Access Journals (Sweden)

    Natalia Matulewicz

    2016-12-01

    Full Text Available Insulin resistance is a condition of reduced biological response to insulin. Growing evidence indicates the role of the chronic low-grade inflammatory response in the pathogenesis of insulin resistance. Adipose tissue in obesity is characterized by increased lipolysis with the excessive release of free fatty acids, and is also a source of proinflammatory cytokines. Both these factors may inhibit insulin action. Proinflammatory cytokines exert their effect by stimulating major inflammatory NFκB and JNK pathways within the cells. Inflammatory processes in other insulin responsive tissues may also play a role in inducing insulin resistance. This paper is an overview of the chronic low-grade inflammation in adipose tissue, skeletal muscle, liver and endothelial cells during the development of insulin resistance.

  17. Endothelins in chronic liver disease

    DEFF Research Database (Denmark)

    Møller, S; Henriksen, Jens Henrik Sahl

    1996-01-01

    renal failure. Studies on liver biopsies have revealed synthesis of ET-1 in hepatic endothelial and other cells, and recent investigations have identified the hepatosplanchnic system as a major source of ET-1 and ET-3 spillover into the circulation, with a direct relation to portal venous hypertension......This review describes recent progress in the accumulation of knowledge about the endothelins (ETs), a family of vasoactive 21-amino acid polypeptides, in chronic liver disease. Particular prominence is given to the dynamics of ET-1 and ET-3 and their possible relation to the disturbed circulation....... In addition, marked associations with disturbance of systemic haemodynamics and with abnormal distribution of blood volume have been reported. Although the pathophysiological importance of the ET system in chronic liver disease is not completely understood, similarities to other vasopressive...

  18. Lithium clearance in chronic nephropathy

    DEFF Research Database (Denmark)

    Kamper, A L; Holstein-Rathlou, N H; Leyssac, P P

    1989-01-01

    1. Lithium clearance measurements were made in 72 patients with chronic nephropathy of different aetiology and moderate to severely reduced renal function. 2. Lithium clearance was strictly correlated with glomerular filtration rate, and there was no suggestion of distal tubular reabsorption...... of lithium or influence of osmotic diuresis. 3. Fractional reabsorption of lithium was reduced in most patients with glomerular filtration rates below 25 ml/min. 4. Calculated fractional distal reabsorption of sodium was reduced in most patients with glomerular filtration rates below 50 ml/min. 5. Lithium...... that lithium clearance may be a measure of the delivery of sodium and water from the renal proximal tubule. With this assumption it was found that adjustment of the sodium excretion in chronic nephropathy initially takes place in the distal parts of the nephron (loop of Henle, distal tubule and collecting duct...

  19. Prevalence of maternal chronic diseases during pregnancy

    DEFF Research Database (Denmark)

    Jølving, Line Riis; Nielsen, Jan; Kesmodel, Ulrik Schiøler

    2016-01-01

    INTRODUCTION: There is substantial evidence of a negative impact of maternal chronic disease during pregnancy on reproductive outcomes. Knowledge of the prevalence of chronic diseases during pregnancy is limited, but essential for a focused preventive effort regarding optimal disease control during...... chronic diseases were chronic lung diseases/asthma (1.73%), thyroid disorders (1.50%) and anxiety and personality disorders (1.33%). Taking increasing maternal age at birth into account, the relative risk for women to have a chronic disease from 2009 to 2013 was 4.14 (95% CI 4.05-4.22), compared...

  20. Omacetaxine Mepesuccinate for Chronic Myeloid Leukemia.

    Science.gov (United States)

    Rosshandler, Yasmin; Shen, Ann Q; Cortes, Jorge; Khoury, Hanna Jean

    2016-05-01

    Omacetaxine mepesuccinate is approved by the Food and Drug Administration in the United States for the treatment of chronic myeloid leukemia in chronic or accelerated phase resistant to two or more tyrosine kinase inhibitors. This review summarizes the mode of action, pharmacokinetics, efficacy and safety of omacetaxine mepesuccinate. Omacetaxine mepesuccinate has activity in chronic myeloid leukemia, especially in the chronic phase, regardless of the presence of ABL1 kinase domain mutations. Omacetaxine mepesuccinate has distinct but manageable adverse events profile. Omacetaxine mepesuccinate is a treatment option for a subset of patients with refractory chronic myeloid leukemia.

  1. Wasting in chronic kidney disease

    OpenAIRE

    Mak, RH; Ikizler, AT; Kovesdy, CP; Raj, DS; Stenvinkel, P; Kalantar-Zadeh, K

    2011-01-01

    Wasting/cachexia is prevalent among patients with chronic kidney disease (CKD). It is to be distinguished from malnutrition, which is defined as the consequence of insufficient food intake or an improper diet. Malnutrition is characterized by hunger, which is an adaptive response, whereas anorexia is prevalent in patients with wasting/cachexia. Energy expenditure decreases as a protective mechanism in malnutrition whereas it remains inappropriately high in cachexia/wasting. In malnutrition, f...

  2. Nitric oxide and chronic colitis

    Directory of Open Access Journals (Sweden)

    Matthew B Grisham

    1996-01-01

    Full Text Available Nitric oxide (NO is thought to play an important role in modulating the inflammatory response by virtue of its ability to affect bloodflow, leukocyte function and cell viability. The objective of this study was to assess the role that NO may play in mediating the mucosal injury and inflammation in a model of chronic granulomatous colitis using two pharmacologically different inhibitors of nitric oxide synthase (NOS. Chronic granulomatous colitis with liver and spleen inflammation was induced in female Lewis rats via the subserosal (intramural injection of peptidoglycan/polysaccharide (PG/PS derived from group A streptococci. Chronic NOS inhibition by oral administration of NG-nitro-L-arginine methyl ester (L-NAME (15 µmol/kg/day or amino-guanidine (AG (15 µmol/ kg/day was found to attenuate the PG/PS-induced increases in macroscopic colonic inflammation scores and colonic myeloperoxidase activity. Only AG -- not L-NAME – attenuated the PG/PS-induced increases in colon dry weight. Both L-NAME and AG significantly attenuated the PG/PS-induced increases in spleen weight whereas neither was effective at significantly attenuating the PG/PS-induced increases in liver weight. Although both L-NAME and AG inhibited NO production in vivo, as measured by decreases in plasma nitrite and nitrate levels, only AG produced significantly lower values (38±3 versus 83±8 µM, respectively, P<0.05. Finally, L-NAME, but not AG, administration significantly increased mean arterial pressure from 83 mmHg in colitic animals to 105 mmHg in the PG/PS+ L-NAME-treated animals (P<0.05. It is concluded that NO may play an important role in mediating some of the pathophysiology associated with this model of chronic granulomatous colitis.

  3. Chronic kidney disease and anticoagulation

    DEFF Research Database (Denmark)

    Sciascia, Savino; Radin, Massimo; Schreiber, Karen

    2017-01-01

    Anticoagulation in patients with impaired kidney function can be challenging since drugs' pharmacokinetics and bioavailability are altered in this setting. Patients with chronic kidney disease (CKD) treated with conventional anticoagulant agents [vitamin K antagonist (VKA), low-molecular weight...... are eliminated via the kidneys pose additional challenges. More recently, two classes of direct oral anticoagulant agents (DOACs) have been investigated for the prevention and management of venous thromboembolic events: the direct factor Xa inhibitors rivaroxaban, apixaban and edoxaban, and the direct thrombin...

  4. Parasites and chronic renal failure

    OpenAIRE

    Mohammadi Manesh, Reza; Hosseini Safa, Ahmad; Sharafi, Seyedeh Maryam; Jafari, Rasool; Bahadoran, Mehran; Yousefi, Morteza; Nasri, Hamid; Yousofi Darani, Hossein

    2014-01-01

    Suppression of the human immune system results in an increase in susceptibility to infection by various infectious agents. Conditions such as AIDS, organ transplantation and chronic renal insufficiency (CRI) are the most important cause of insufficient immune response against infections. Long term renal disorders result in uremia, which can suppress human immune system. Parasitic infections are one of the most important factors indicating the public health problems of the societies. These inf...

  5. Chronic alcoholism and microbial keratitis.

    OpenAIRE

    Ormerod, L. D.; Gomez, D. S.; Schanzlin, D. J.; Smith, R. E.

    1988-01-01

    In a series of 227 consecutive, non-referred patients with microbial keratitis an analysis of the accumulated hospital records showed that one-third were associated with chronic alcoholism. The diagnosis of alcoholism was usually unsuspected on admission to hospital. The microbial pathogenesis in these patients was distinctive; coagulase-negative staphylococci, alpha- and beta-streptococci, moraxellae, enteric Gram-negative bacilli, and polymicrobial infections were unusually prominent. Pseud...

  6. NAFLD and Chronic Kidney Disease.

    Science.gov (United States)

    Marcuccilli, Morgan; Chonchol, Michel

    2016-04-14

    Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in developed countries and it is now considered a risk factor for cardiovascular disease. Evidence linking NAFLD to the development and progression of chronic kidney disease (CKD) is emerging as a popular area of scientific interest. The rise in simultaneous liver-kidney transplantation as well as the significant cost associated with the presence of chronic kidney disease in the NAFLD population make this entity a worthwhile target for screening and therapeutic intervention. While several cross-sectional and case control studies have been published to substantiate these theories, very little data exists on the underlying cause of NAFLD and CKD. In this review, we will discuss the most recent publications on the diagnosis of NAFLD as well new evidence regarding the pathophysiology of NAFLD and CKD as an inflammatory disorder. These mechanisms include the role of obesity, the renin-angiotensin system, and dysregulation of fructose metabolism and lipogenesis in the development of both disorders. Further investigation of these pathways may lead to novel therapies that aim to target the NAFLD and CKD. However, more prospective studies that include information on both renal and liver histology will be necessary in order to understand the relationship between these diseases.

  7. Acute and chronic otitis media.

    Science.gov (United States)

    Morris, Peter S; Leach, Amanda J

    2009-12-01

    Otitis media (OM) is a common illness in young children. OM has historically been associated with frequent and severe complications. Nowadays it is usually a mild condition that often resolves without treatment. For most children, progression to tympanic membrane perforation and chronic suppurative OM is unusual (low-risk populations); this has led to reevaluation of many interventions that were used routinely in the past. Evidence from a large number of randomized controlled trials can help when discussing treatment options with families. Indigenous children in the United States, Canada, Northern Europe, Australia, and New Zealand experience more OM than other children. In some places, Indigenous children continue to suffer from the most severe forms of the disease. Communities with more than 4% of the children affected by chronic tympanic membrane perforation have a major public health problem (high-risk populations). Higher rates of invasive pneumococcal disease, pneumonia, and chronic suppurative lung disease (including bronchiectasis) are also seen. These children will often benefit from effective treatment of persistent (or recurrent) bacterial infection.

  8. Superoxide dismutases in chronic gastritis.

    Science.gov (United States)

    Švagelj, Dražen; Terzić, Velimir; Dovhanj, Jasna; Švagelj, Marija; Cvrković, Mirta; Švagelj, Ivan

    2016-04-01

    Human gastric diseases have shown significant changes in the activity and expression of superoxide dismutase (SOD) isoforms. The aim of this study was to detect Mn-SOD activity and expression in the tissue of gastric mucosa, primarily in chronic gastritis (immunohistochemical Helicobacter pylori-negative gastritis, without other pathohistological changes) and to evaluate their possible connection with pathohistological diagnosis. We examined 51 consecutive outpatients undergoing endoscopy for upper gastrointestinal symptoms. Patients were classified based on their histopathological examinations and divided into three groups: 51 patients (archive samples between 2004-2009) with chronic immunohistochemical Helicobacter pylori-negative gastritis (mononuclear cells infiltration were graded as absent, moderate, severe) divided into three groups. Severity of gastritis was graded according to the updated Sydney system. Gastric tissue samples were used to determine the expression of Mn-SOD with anti-Mn-SOD Ab immunohistochemically. The Mn-SOD expression was more frequently present in specimens with severe and moderate inflammation of gastric mucosa than in those with normal mucosa. In patients with normal histological finding, positive immunoreactivity of Mn-SOD was not found. Our results determine the changes in Mn-SOD expression occurring in the normal gastric mucosa that had undergone changes in the intensity of chronic inflammatory infiltrates in the lamina propria. © 2016 APMIS. Published by John Wiley & Sons Ltd.

  9. Integrative medicine for chronic pain

    Science.gov (United States)

    Saha, Felix J.; Brüning, Alexander; Barcelona, Cyrus; Büssing, Arndt; Langhorst, Jost; Dobos, Gustav; Lauche, Romy; Cramer, Holger

    2016-01-01

    Abstract Introduction: Integrative medicine inpatient treatment has been shown to improve physical and mental health in patients with internal medicine conditions. The aim of this study was to investigate the effectiveness of a 2-week integrative medicine inpatient treatment in patients with chronic pain syndromes and the association of treatment success with patient-related process variables. Methods: Inpatients with chronic pain syndromes participating in a 2-week integrative medicine inpatient program were included. Patients’ pain intensity, pain disability, pain perception, quality of life, depression, and perceived stress were measured on admission, discharge, and 6 months after discharge. Likewise process variables including ability and will to change, emotional/rational disease acceptance, mindfulness, life and health satisfaction, and easiness of life were assessed. Results: A total of 310 inpatients (91% female, mean age 50.7 ± 12.4 year, 26.5% low back pain, and 22.9% fibromyalgia) were included. Using mixed linear models, significant improvements in pain intensity, pain disability, pain perception, quality of life, depression, and perceived stress were found (all P medicine inpatient treatment can benefit patients with chronic pain conditions. Functional improvements are associated with improved ability to change and implementation, disease acceptance, and satisfaction. PMID:27399133

  10. The cost of chronic constipation.

    Science.gov (United States)

    Pekmezaris, Renée; Aversa, Lorraine; Wolf-Klein, Gisele; Cedarbaum, Jesse; Reid-Durant, Marie

    2002-01-01

    This study investigates the cost of chronic constipation care. A consecutive sample of 31 chronically constipated elderly patients. A not-for-profit long-term care facility in New Hyde Park, New York. Patient demographics and functional status, including activity of daily living scores, diagnosis, and medications were recorded. All constipation medication costs were obtained using the average wholesale price obtained from the Redbook (November 1999). All subjects were closely monitored for constipation care during two shifts a day (from 7:00 AM to 11:00 PM), over a 6-week period resulting in the collection of 1,860 shift reports. Each component of constipation treatment cost, namely drugs and staff time for drug administration, was identified and analyzed. The average number of nursing interactions for constipation treatment was 23.3 per month. The average cost per day for care specifically for the treatment of constipation was 2.11 US dollars. Fleet Enema trade mark and milk of magnesia accounted for 49% of all treatments. Administration (staffing) costs accounted for 70% of total drug costs. Although laxatives are the most frequently prescribed drugs used in long-term care settings, drug utilization patterns and associated costs in the treatment of chronic constipation have not been systematically reported. Our study identified staffing as the major cost factor in constipation care.

  11. [Drug interactions in chronic prescription].

    Science.gov (United States)

    Comet, D; Casajuana, J; Bordas, J M; Fuentes, M A; Arnáiz, J A; Núñez, B; Pou, R

    1997-06-30

    Application of computerized program for detection of potential drug interactions (PDI) in chronic prescriptions in four primary care centers. To evaluate the clinical significance of PDI identified according to clinical criterions. An observational crossover study. Clutat Vella health district (City of Barcelona). Using information of Consejo General de Colegios Oficiales de Farmaceuticos databases and the chronic prescriptions database of the primary care centers, computerized drug-interaction system have been developed for detection of PDI in patients. A panel of primary care physicians and clinical pharmacists developed criteria that were used to evaluate the clinical significance of PDI. 9840 Cards of Authorized Prescription (CAP) were analyzed, 36108 medicaments and 42877 drugs. A total of 2140 patients were involved for a total of 3406 PDI, 21.75% of patients with CAP. Clinical signification for the panel was found in 40.07% of these 3406 PIF; 3.78% were suggest to avoid the association drugs. The incidence of PDI with clinical signification are lower than other studies of the literature; it suggest a appropriate knowledge of drug prescription. The application of computerized program make much more easy the detection of adverse drug interactions in chronic prescription.

  12. Ultrasonography in chronic renal failure

    International Nuclear Information System (INIS)

    Buturovic-Ponikvar, Jadranka; Visnar-Perovic, Alenka

    2003-01-01

    Many chronic renal diseases lead to the final common state of decrease in renal size, parenchymal atrophy, sclerosis and fibrosis. The ultrasound image show a smaller kidney, thinning of the parenchyma and its hyperechogenicity (reflecting sclerosis and fibrosis). The frequency of renal cysts increases with the progression of the disease. Ultrasound generally does not allow for the exact diagnosis of an underlying chronic disease (renal biopsy is usually required), but it can help to determine an irreversible disease, assess prognosis and avoid unnecessary diagnostic or therapeutic procedures. The main exception in which the ultrasound image does not show a smaller kidney with parenchymal atrophy is diabetic nephropathy, the leading cause of chronic and end-stage renal failure in developed countries in recent years. In this case, both renal size and parenchymal thickness are preserved until end-stage renal failure. Doppler study of intrarenal vessels can provide additional information about microvascular and parenchymal lesions, which is helpful in deciding for or against therapeutic intervention and timely planning for optimal renal replacement therapy option

  13. [Chronic diarrhea: etiologies and diagnostic evaluation].

    Science.gov (United States)

    Schoepfer, A

    2008-04-30

    Chronic diarrhea is defined as a decrease in fecal consistency lasting for four or more weeks. A myriad of disorders are associated with chronic diarrhea. In developed countries, chronic diarrhea is mostly caused by non-infectious diseases. There are four pathogenic mechanisms leading to chronic diarrhea: osmotic diarrhea, secretory diarrhea, inflammatory diarrhea, and dysmotility. Overlaps between these mechanisms are possible. A 72-hour fecal collection as well as the fasting test are important diagnostic tools to identify the underlying pathomechanism. The identification of the pathomechanism narrows down the possible etiologies of chronic diarrhea and allows therefore a cost-saving diagnostic workup. The endoscopy is well established in the workup of chronic diarrhea. This article gives an overview about the main causes and mechanisms leading to chronic diarrhea and proposes an algorithm for the diagnostic evalution.

  14. Surgical therapy in chronic pancreatitis.

    Science.gov (United States)

    Neal, C P; Dennison, A R; Garcea, G

    2012-12-01

    Chronic pancreatitis (CP) is an inflammatory disease of the pancreas which causes chronic pain, as well as exocrine and endocrine failure in the majority of patients, together producing social and domestic upheaval and a very poor quality of life. At least half of patients will require surgical intervention at some stage in their disease, primarily for the treatment of persistent pain. Available data have now confirmed that surgical intervention may produce superior results to conservative and endoscopic treatment. Comprehensive individual patient assessment is crucial to optimal surgical management, however, in order to determine which morphological disease variant (large duct disease, distal stricture with focal disease, expanded head or small duct/minimal change disease) is present in the individual patient, as a wide and differing range of surgical approaches are possible depending upon the specific abnormality within the gland. This review comprehensively assesses the evidence for these differing approaches to surgical intervention in chronic pancreatitis. Surgical drainage procedures should be limited to a small number of patients with a dilated duct and no pancreatic head mass. Similarly, a small population presenting with a focal stricture and tail only disease may be successfully treated by distal pancreatectomy. Long-term results of both of these procedure types are poor, however. More impressive results have been yielded for the surgical treatment of the expanded head, for which a range of surgical options now exist. Evidence from level I studies and a recent meta-analysis suggests that duodenum-preserving resections offer benefits compared to pancreaticoduodenectomy, though the results of the ongoing, multicentre ChroPac trial are awaited to confirm this. Further data are also needed to determine which of the duodenum-preserving procedures provides optimal results. In relation to small duct/minimal change disease total pancreatectomy represents the only

  15. Prevalence rate of chronic overuse pain in taekwondo athletes.

    Science.gov (United States)

    Koh, Jae-Ok

    2017-10-01

    The aim of this study was to estimate the prevalence of chronic overuse pain (COP) and to identify possible risk factors of COP in sport poomsae taekwondo. This is a cross-sectional survey. A total of 263 sport-poomsae competitors (112 females; 151 males; aged between 12-44 years), who competed at the 2014 sport poomsae taekwondo competition, participated in this study. The prevalence rate of COP and possible risk factors associated with COP were analyzed by using Chi-square tests and independent t-tests. A total of 173 athletes reported that they experienced COP (65.8%; 95% confidence interval [CI]: 60.5-71.5). Female athletes showed a higher prevalence rate than their male counterparts (75.9% vs. 58.3%). Lower body (61.5%) and knee joints (26.4%) were the two primarily injured body part. A total of 101 athletes reported that they injured in the previous year. Among those, 81.2% were suffered from COP. The technique that caused pain most frequently was side-kick among females and front-kick among males. Prevalence rates of COP were significantly different by sex, education level, training hour, and a history of injury. The prevalence of COP is high among sport poomsae taekwondo athletes. Competitors who are female, have a history of injury, and train for extended hours were more likely to experience COP. To identify other potential risk factors of COP in sport poomsae taekwondo, more research is needed to build upon the findings.

  16. Mesenchymal Stromal Cells from Osteoarthritic Synovium Are a Distinct Population Compared to Their Bone-Marrow Counterparts regarding Surface Marker Distribution and Immunomodulation of Allogeneic CD4+ T-Cell Cultures

    Directory of Open Access Journals (Sweden)

    Sebastien Hagmann

    2016-01-01

    Full Text Available Introduction. The participation of an inflammatory joint milieu has been described in osteoarthritis (OA pathogenesis. Mesenchymal stromal cells (MSCs play an important role in modulating inflammatory processes. Based on previous studies in an allogeneic T-cell coculture model, we aimed at further determining the role of synovial MSCs in OA pathogenesis. Methods. Bone-marrow (BM and synovial membrane (SM MSCs from hip joints of late stage OA patients and CD4+ T-cells from healthy donors were analysed regarding surface marker expression before and after coculture. Proliferation upon CD3/CD28 stimulation and cytokine analyses were compared between MSCs. Results. SM-MSCs differed from BM-MSCs in several surface markers and their osteogenic differentiation potential. Cocultures of both MSCs with CD4+ T-cells resulted in recruitment of CD45RA+ FoxP3+ regulatory T-cells. Upon stimulation, only SM-MSCs suppressed CD4+ T-cell proliferation, while both SM-MSCs and BM-MSCs modified cytokine profiles through suppressing IL-2 and TNF-α as well as increasing IL-6 secretion. Conclusions. Synovial MSCs from OA joints are a unique fraction that can be distinguished from their bone-marrow derived counterparts. Their unique ability to suppress CD3/CD28 induced CD4+ T-cell proliferation makes them a potential target for future therapeutic approaches.

  17. The Electromagnetic Counterpart of the Binary Neutron Star Merger LIGO/Virgo GW170817. IV. Detection of Near-infrared Signatures of r -process Nucleosynthesis with Gemini-South

    Energy Technology Data Exchange (ETDEWEB)

    Chornock, R. [Astrophysical Institute, Department of Physics and Astronomy, 251B Clippinger Lab, Ohio University, Athens, OH 45701 (United States); Berger, E.; Cowperthwaite, P. S.; Nicholl, M.; Villar, V. A.; Alexander, K. D.; Blanchard, P. K.; Eftekhari, T.; Williams, P. K. G. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Kasen, D. [Departments of Physics and Astronomy, and Theoretical Astrophysics Center, University of California, Berkeley, CA 94720-7300 (United States); Fong, W.; Margutti, R. [Center for Interdisciplinary Exploration and Research in Astrophysics (CIERA) and Department of Physics and Astronomy, Northwestern University, Evanston, IL 60208 (United States); Annis, J.; Frieman, J. A. [Fermi National Accelerator Laboratory, P.O. Box 500, Batavia, IL 60510 (United States); Brout, D. [Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104 (United States); Brown, D. A. [Department of Physics, Syracuse University, Syracuse NY 13224 (United States); Chen, H.-Y. [Department of Astronomy and Astrophysics, University of Chicago, Chicago, IL 60637 (United States); Drout, M. R. [The Observatories of the Carnegie Institution for Science, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); Farr, B. [Department of Physics, University of Oregon, Eugene, OR 97403 (United States); Foley, R. J., E-mail: chornock@ohio.edu [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); and others

    2017-10-20

    We present a near-infrared spectral sequence of the electromagnetic counterpart to the binary neutron star merger GW170817 detected by Advanced Laser Interferometer Gravitational-wave Observatory (LIGO)/Virgo. Our data set comprises seven epochs of J + H spectra taken with FLAMINGOS-2 on Gemini-South between 1.5 and 10.5 days after the merger. In the initial epoch, the spectrum is dominated by a smooth blue continuum due to a high-velocity, lanthanide-poor blue kilonova component. Starting the following night, all of the subsequent spectra instead show features that are similar to those predicted in model spectra of material with a high concentration of lanthanides, including spectral peaks near 1.07 and 1.55 μ m. Our fiducial model with 0.04 M {sub ⊙} of ejecta, an ejection velocity of v = 0.1 c , and a lanthanide concentration of X {sub lan} = 10{sup −2} provides a good match to the spectra taken in the first five days, although it over-predicts the late-time fluxes. We also explore models with multiple fitting components, in each case finding that a significant abundance of lanthanide elements is necessary to match the broad spectral peaks that we observe starting at 2.5 days after the merger. These data provide direct evidence that binary neutron star mergers are significant production sites of even the heaviest r -process elements.

  18. [Chronic wounds as a public health problem].

    Science.gov (United States)

    Situm, Mirna; Kolić, Maja; Redzepi, Gzim; Antolić, Slavko

    2014-10-01

    Chronic wounds represent a significant burden to patients, health care professionals and the entire health care system. Regarding the healing process, wounds can be classified as acute or chronic wounds. A wound is considered chronic if healing does not occur within the expected period according to the wound etiology and localization. Chronic wounds can be classified as typical and atypical. The majority of wounds (95 percent) are typical ones, which include ischemic, neurotrophic and hypostatic ulcers and two separate entities: diabetic foot and decubital ulcers. Eighty percent of chronic wounds localized on lower leg are the result of chronic venous insufficiency, in 5-10 percent the cause is of arterial etiology, whereas the rest are mostly neuropathic ulcers. Chronic wounds significantly decrease the quality of life of patients by requiring continuous topical treatment, causing immobility and pain in a high percentage of patients. Chronic wounds affect elderly population. Chronic leg ulcers affect 0.6-3 percent of those aged over 60, increasing to over 5 percent of those aged over 80. Emergence of chronic wounds is a substantial socioeconomic problem as 1-2 percent of western population will suffer from it. This estimate is expected to rise due to the increasing proportion of elderly population along with the diabetic and obesity epidemic. It has been proved that chronic wounds account for the large proportion of costs in the health care system, even in rich societies. Socioeconomically, the management of chronic wounds reaches a total of 2-4 percent of the health budget in western countries. Treatment costs for some other diseases are not irrelevant, nor are the method and materials used for treating these wounds. Considering etiologic factors, a chronic wound demands a multidisciplinary approach with great efforts of health care professionals to treat it more efficiently, more simply and more painlessly for the patient, as well as more inexpensively for

  19. of chronic kidney disease advancement

    Directory of Open Access Journals (Sweden)

    Jolanta Szeliga-Król

    2016-09-01

    Full Text Available Background . Chronic kidney disease (CKD is at present a worldwide health problem. According to the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF KDOQI, chronic kidney disease has five stages of advancement based on the estimated glomerular filtration rate (eGFR. The formulas that are most frequently used in determining eGFR are the Cockroft–Gault (CG formula, the simplified Modification of Diet in Renal Disease (MDRD formula, and the Chronic Kidney Disease Epidemiology (CKD-EPI Collaboration formula, which is considered the most accurate formula. Objectives . The aim of our study was to compare the CG, simplified MDRD and CKD-EPI formulas for determining eGFR and thus CKD advancement. Material and methods. The study was conducted on a group of 202 patients with previously diagnosed CKD. To calculate the eGFR, the CG, simplified MDRD, and CKD-EPI formulas were used. Patients were assigned a disease stage (from 1 to 5 according to the NKF KDOQI guidelines. Results . The calculated eGFR values varied depending on the formula, which resulted different assignations of patients to CKD stages. The largest difference regarded the qualification of the patients to the first and the fifth stage. A similar number of patients were classed as stage three by all formulas. Differences were also seen in how the formulas classified patients to the second and fourth stages. Conclusions . GFR estimation remains a problematic clinical concern. The CKD stage assigned to patients varies depending on the formula used, a fact which may be particularly significant for general practitioners. Laboratories should apply the CKD-EPI formula for eGFR calculation, as it gives the least false results.

  20. Nonpharmacologic Management of Chronic Insomnia.

    Science.gov (United States)

    Maness, David L; Khan, Muneeza

    2015-12-15

    Insomnia affects 10% to 30% of the population with a total cost of $92.5 to $107.5 billion annually. Short-term, chronic, and other types of insomnia are the three major categories according to the International Classification of Sleep Disorders, 3rd ed. The criteria for diagnosis are difficulty falling asleep, difficulty staying asleep, or early awakening despite the opportunity for sleep; symptoms must be associated with impaired daytime functioning and occur at least three times per week for at least one month. Factors associated with the onset of insomnia include a personal or family history of insomnia, easy arousability, poor self-reported health, and chronic pain. Insomnia is more common in women, especially following menopause and during late pregnancy, and in older adults. A comprehensive sleep history can confirm the diagnosis. Psychiatric and medical problems, medication use, and substance abuse should be ruled out as contributing factors. Treatment of comorbid conditions alone may not resolve insomnia. Patients with movement disorders (e.g., restless legs syndrome, periodic limb movement disorder), circadian rhythm disorders, or breathing disorders (e.g., obstructive sleep apnea) must be identified and treated appropriately. Chronic insomnia is associated with cognitive difficulties, anxiety and depression, poor work performance, decreased quality of life, and increased risk of cardiovascular disease and all-cause mortality. Insomnia can be treated with nonpharmacologic and pharmacologic therapies. Nonpharmacologic therapies include sleep hygiene, cognitive behavior therapy, relaxation therapy, multicomponent therapy, and paradoxical intention. Referral to a sleep specialist may be considered for refractory cases.

  1. HIV and chronic kidney disease

    OpenAIRE

    Naicker, Saraladevi; Rahmania, Sadaf; Kopp, Jeffrey B.

    2015-01-01

    Chronic kidney disease (CKD) is a frequent complication of HIV infection, occurring in 3.5 – 48.5%, and occurs as a complication of HIV infection, other co-morbid disease and infections and as a consequence of therapy of HIV infection and its complications. The classic involvement of the kidney by HIV infection is HIV-associated nephropathy (HIVAN), occurring typically in young adults of African ancestry with advanced HIV disease in association with APOL1 high-risk variants. HIV-immune comple...

  2. Treatment of refractory chronic urticaria

    Directory of Open Access Journals (Sweden)

    Aayushi Mehta

    2015-01-01

    Full Text Available Chronic spontaneous urticaria is a distressing disease encountered frequently in clinical practice. The current mainstay of therapy is the use of second-generation, non-sedating antihistamines. However, in patients who do not respond satisfactorily to these agents, a variety of other drugs are used. This article examines the available literature for frequently used agents including systemic corticosteroids, leukotriene receptor antagonists, dapsone, sulfasalazine, hydroxychloroquine, H2 antagonists, methotrexate, cyclosporine A, omalizumab, autologous serum therapy, and mycophenolate mofetil, with an additional focus on publications in Indian literature.

  3. Endothelins in chronic liver disease

    DEFF Research Database (Denmark)

    Møller, Søren; Henriksen, Jens Henrik

    1996-01-01

    This review describes recent progress in the accumulation of knowledge about the endothelins (ETs), a family of vasoactive 21-amino acid polypeptides, in chronic liver disease. Particular prominence is given to the dynamics of ET-1 and ET-3 and their possible relation to the disturbed circulation...... renal failure. Studies on liver biopsies have revealed synthesis of ET-1 in hepatic endothelial and other cells, and recent investigations have identified the hepatosplanchnic system as a major source of ET-1 and ET-3 spillover into the circulation, with a direct relation to portal venous hypertension...

  4. [Tropical chronic pancreatitis in a young patient].

    Science.gov (United States)

    Reyes, J; Ginard, D; Barranco, L; Riera, J; Obrador, A

    2001-11-01

    Tropical chronic pancreatitis is a form of idiopathic chronic pancreatitis that has not previously been described in Spain. Typically it is related to dietary factors and malnutrition, although genetic factors may also play a significant role in the development of the disease. We report a case of chronic tropical pancreatitis in a 27-year-old woman from the Dominican Republic domiciled in Spain since 1992. The patient was admitted to our hospital for acute pancreatitis that fulfilled the diagnostic criteria (clinical and radiological) for chronic tropical pancreatitis. This case has led us to review this uncommon entity. Because of the increasing number of immigrants from tropical countries, chronic tropical pancreatitis will probably need to be taken into account in the differential diagnosis of chronic pancreatitis in our patients.

  5. New Directions in Chronic Disease Management

    Directory of Open Access Journals (Sweden)

    Hun-Sung Kim

    2015-06-01

    Full Text Available A worldwide epidemic of chronic disease, and complications thereof, is underway, with no sign of abatement. Healthcare costs have increased tremendously, principally because of the need to treat chronic complications of non-communicable diseases including cardiovascular disease, blindness, end-stage renal disease, and amputation of extremities. Current healthcare systems fail to provide an appropriate quality of care to prevent the development of chronic complications without additional healthcare costs. A new paradigm for prevention and treatment of chronic disease and the complications thereof is urgently required. Several clinical studies have clearly shown that frequent communication between physicians and patients, based on electronic data transmission from medical devices, greatly assists in the management of chronic disease. However, for various reasons, these advantages have not translated effectively into real clinical practice. In the present review, we describe current relevant studies, and trends in the use of information technology for chronic disease management. We also discuss limitations and future directions.

  6. Airway inflammation in nonobstructive and obstructive chronic bronchitis with chronic haemophilus influenzae airway infection. Comparison with noninfected patients with chronic obstructive pulmonary disease

    NARCIS (Netherlands)

    Bresser, P.; Out, T. A.; van Alphen, L.; Jansen, H. M.; Lutter, R.

    2000-01-01

    Nonencapsulated Haemophilus influenzae often causes chronic infections of the lower respiratory tract in both nonobstructive and obstructive chronic bronchitis. We assessed airway inflammation in clinically stable, chronically H. influenzae-infected patients with nonobstructive (CB-HI, n = 10) and

  7. Radiofrequency Wire Recanalization of Chronically Thrombosed TIPS

    Energy Technology Data Exchange (ETDEWEB)

    Majdalany, Bill S., E-mail: bmajdala@med.umich.edu [University of Michigan Health System, Division of Interventional Radiology, Department of Radiology (United States); Elliott, Eric D., E-mail: eric.elliott@osumc.edu [The Ohio State University Wexner Medical Center, Division of Interventional Radiology, Department of Radiology (United States); Michaels, Anthony J., E-mail: Anthony.michaels@osumc.edu; Hanje, A. James, E-mail: James.Hanje@osumc.edu [The Ohio State University Wexner Medical Center, Division of Gastroenterology and Hepatology, Department of Medicine (United States); Saad, Wael E. A., E-mail: wsaad@med.umich.edu [University of Michigan Health System, Division of Interventional Radiology, Department of Radiology (United States)

    2016-07-15

    Radiofrequency (RF) guide wires have been applied to cardiac interventions, recanalization of central venous thromboses, and to cross biliary occlusions. Herein, the use of a RF wire technique to revise chronically occluded transjugular intrahepatic portosystemic shunts (TIPS) is described. In both cases, conventional TIPS revision techniques failed to revise the chronically thrombosed TIPS. RF wire recanalization was successfully performed through each of the chronically thrombosed TIPS, demonstrating initial safety and feasibility in this application.

  8. A vicious circle in chronic lymphoedema pathophysiology?

    DEFF Research Database (Denmark)

    Cucchi, F; Rossmeislova, L; Simonsen, L

    2017-01-01

    Chronic lymphoedema is a disease caused by a congenital or acquired damage to the lymphatic system and characterized by complex chains of pathophysiologic events such as lymphatic fluid stasis, chronic inflammation, lymphatic vessels impairment, adipose tissue deposition and fibrosis. These event....... Together, these observations indicate strong reciprocal relationship between lymphatics and adipose tissue and suggest a possible key role of the adipocyte in the pathophysiology of chronic lymphoedema's vicious circle....

  9. A lithium-sensitive and sodium-tolerant 3'-phosphoadenosine-5'-phosphatase encoded by halA from the cyanobacterium Arthrospira platensis is closely related to its counterparts from yeasts and plants.

    Science.gov (United States)

    Zhang, Ju-Yuan; Zou, Jie; Bao, Qiyu; Chen, Wen-Li; Wang, Li; Yang, Huanming; Zhang, Cheng-Cai

    2006-01-01

    3'-Phosphoadenosine-5'-phosphatase (PAPase) is required for the removal of toxic 3'-phosphoadenosine-5'-phosphate (PAP) produced during sulfur assimilation in various eukaryotic organisms. This enzyme is a well-known target of lithium and sodium toxicity and has been used for the production of salt-resistant transgenic plants. In addition, PAPase has also been proposed as a target in the treatment of manic-depressive patients. One gene, halA, which could encode a protein closely related to the PAPases of yeasts and plants, was identified from the cyanobacterium Arthrospira (Spirulina) platensis. Phylogenic analysis indicated that proteins related to PAPases from several cyanobacteria were found in different clades, suggesting multiple origins of PAPases in cyanobacteria. The HalA polypeptide from A. platensis was overproduced in Escherichia coli and used for the characterization of its biochemical properties. HalA was dependent on Mg2+ for its activity and could use PAP or 3'-phosphoadenosine-5'-phosphosulfate as a substrate. HalA is sensitive to Li+ (50% inhibitory concentration [IC50] = 3.6 mM) but only slightly sensitive to Na+ (IC50 = 600 mM). The salt sensitivity of HalA was thus different from that of most of its eukaryotic counterparts, which are much more sensitive to both Li+ and Na+, but was comparable to the PAPase AtAHL (Hal2p-like protein) from Arabidopsis thaliana. The properties of HalA could help us to understand the structure-function relationship underlying the salt sensitivity of PAPases. The expression of halA improved the Li+ tolerance of E. coli, suggesting that the sulfur-assimilating pathway is a likely target of salt toxicity in bacteria as well.

  10. Cortisol responses to chronic stress in adult macaques: moderation by a polymorphism in the serotonin transporter gene.

    Science.gov (United States)

    Qin, Dongdong; Rizak, Joshua; Feng, Xiaoli; Yang, Shangchuan; Yang, Lichuan; Fan, Xiaona; Lü, Longbao; Chen, Lin; Hu, Xintian

    2015-02-01

    Accumulating evidence has shown that a polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) moderates the association between stress and depressive symptoms. However, the exact etiologies underlying this moderation are not well understood. Here it is reported that among adult female rhesus macaques, an orthologous polymorphism (rh5-HTTLPR) exerted an influence on cortisol responses to chronic stress. It was found that females with two copies of the short allele were associated with increased cortisol responses to chronic stress in comparison to their counterparts who have one or two copies of the long allele. In the absence of stress, no differences related to genotype were observed in these females. This genetic moderation was found without a genetic influence on exposure to stressful situations. Rather it was found to be a genetic modulation of cortisol responses to chronic stress. These findings indicate that the rh5-HTTLPR polymorphism is closely related to hypothalamus-pituitary-adrenal (HPA) axis reactivity, which may increase susceptibility to depression in females with low serotonin transporter efficiency and a history of stress. Copyright © 2014 Elsevier B.V. All rights reserved.

  11. The Role of Maternal Distress in the Report of Behavioral and Emotional Problems among Children with Chronic Disabilities.

    Science.gov (United States)

    Silberg, Tamar; Brezner, Amichai; Gal, Gilad; Ahonniska-Assa, Jaana; Levav, Miriam

    2016-01-01

    Assessments of psychological symptoms in children often rely on caregivers' (usually mothers') reports. However, the reliability may be affected by the caregivers' own emotional distress (ED). The main objectives of this study were to assess the variability in ED of mothers of children with chronic physical disabilities, and its association with the ratings of their children's emotional and behavioral problems. Medical data of children diagnosed with chronic disabilities were analyzed (N = 72). Mothers completed the 12-item General Health Questionnaire (12-GHQ) to measure ED and the Child Behavior Checklist (CBCL) to assess children's emotional and behavioral problems Mothers' ED scores were compared with communitybased counterparts with similar socio-demographic characteristics (N = 657) from the Israel National Health Survey (INHS). Mothers of children with chronic physical disabilities had higher levels of ED compared to mothers in the general population. About 20% of the sample mothers had 12-GHQ scores compatible with DSM- IV depression or anxiety disorders. No differences in ED were found according to the type of child's disability or IQ score. Marked differences in CBCL scores were reported by mothers with high versus low ED, controlling for baseline maternal and child characteristics. High levels of maternal ED were associated with mothers' reports on child's behavioral and emotional problems.This may contaminate the reliability of parental reports on their child's psychological state.

  12. Muscle histochemistry in chronic alcoholism

    Directory of Open Access Journals (Sweden)

    M. L. Ferraz

    1989-06-01

    Full Text Available Twenty-two chronic acoholic patients were assessed by neurologic examination and muscle biopsy. The patients manifested proximal muscular weakness to a variable extent. One case presented as an acute bout of myopathy, according to the Manual Muscle Test, MMT. The most prominent histologic feature observed was muscle atrophy (95.3% better evidenced through the ATPase stain with the predominance of type II A fibers (71.4%. Lack of the mosaic pattern (type grouping seen in 76% of the cases and an important mitochondrial proliferation with intrasarcoplasmatic lipid accumulation in 63% of the patients. In case of acute presentation of muscle weakness the. pathological substrate is quite different, i.e. presence of myositis mainly interstitial characterized by lymphoplasmocytic infiltrate and several spots of necrosis like Zencker degeneration. Based on histologic criteria, our data suggest that: the main determinant of muscle weakness seen in chronic alcoholic patients is neurogenic in origin (alcoholic polineuropathy; the direct toxic action of ethanol under the skeletal muscle is closely related to the mitochondrial metabolism; the so-called acute alcoholic myopathy has probably viral etiology.

  13. Anemia of Chronic Liver Diseases

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Hyun Chung; Lee, Jhung Sang; Koh, Chang Soon; Lee, Mun Ho [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1971-09-15

    The pathogenetic mechanisms of anemia in patients with chronic liver disease were observed. Seventeen patients with moderate to advanced hepatic diseases were studied by various methods. Only patients without previous blood loss were included : 14 had cirrhosis, 2 had active chronic hepatitis, and one had inferior vena cava obstruction with associated liver cirrhosis. The followings were the results: 1. The anemia based on red blood cell count, Hb., and Ht. was found in 76.5-78.6% of the patients. 2. Red cell indices indicated that normo-macrocytic and normochromic anemia was present is the majority of the patients. 3. No evidence of megaloblastic anemia was found on the basis of the morphological examinations. 4. Serum iron, TIBC, % saturation and iron content in the bone marrow indicated that iron deficiency anemia was present in about half of the patients. 5. In the view of the erythrocyte dynamics, primary increase in the red cell destruction was ascribed to the cause of the anemia. 6. Decrease in the red cell survival time was not correlated with MCV, % saturation and S.L. ratio. Also, hemoglobin level was not correlated with MCV, % saturation and T{sub 50} Cr. Therefore, multiple causes may be involved in the pathogenesis of the anemia. 7. Anemia as determined by the red cell volume was found in only 60% of the patients. It may be possible that hemodilutional anemia is present.

  14. Biofeedback training in chronic constipation.

    Science.gov (United States)

    Benninga, M A; Büller, H A; Taminiau, J A

    1993-01-01

    Twenty nine patients, aged 5-16 years, were studied to evaluate whether biofeedback training is effective in treating children with chronic constipation and encopresis; the clinical outcome at six weeks and 12 months was also evaluated. Patients received on average five biofeedback training sessions. The existence of external anal contraction or decreased rectal sensation in 16 (55%) and eight (27%) of the children, respectively was identified on manometry. After biofeedback training, 26 (90%) of the patients learned to relax the external anal sphincter; 18 (63%) normalised rectal sensation. The training resulted in a significant increase in defecation frequency and a significant decrease in encopresis. At six weeks, 16 (55%) of the patients were clinically symptom free. At follow up after 12 months the results were sustained. Only three patients showed a relapse within six months, of whom two were successfully treated with one extra training session. Biofeedback training might be a useful therapeutical approach in children with chronic constipation and encopresis. PMID:8434996

  15. Placental Origins of Chronic Disease

    Science.gov (United States)

    Burton, Graham J.; Fowden, Abigail L.; Thornburg, Kent L.

    2016-01-01

    Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to events during their intrauterine phase of development. Biologically this should not be unexpected, for organ systems are at their most plastic when progenitor cells are proliferating and differentiating. Influences operating at this time can permanently affect their structure and functional capacity, and the activity of enzyme systems and endocrine axes. It is now appreciated that such effects lay the foundations for a diverse array of diseases that become manifest many years later, often in response to secondary environmental stressors. Fetal development is underpinned by the placenta, the organ that forms the interface between the fetus and its mother. All nutrients and oxygen reaching the fetus must pass through this organ. The placenta also has major endocrine functions, orchestrating maternal adaptations to pregnancy and mobilizing resources for fetal use. In addition, it acts as a selective barrier, creating a protective milieu by minimizing exposure of the fetus to maternal hormones, such as glucocorticoids, xenobiotics, pathogens, and parasites. The placenta shows a remarkable capacity to adapt to adverse environmental cues and lessen their impact on the fetus. However, if placental function is impaired, or its capacity to adapt is exceeded, then fetal development may be compromised. Here, we explore the complex relationships between the placental phenotype and developmental programming of chronic disease in the offspring. Ensuring optimal placentation offers a new approach to the prevention of disorders such as cardiovascular disease, diabetes, and obesity, which are reaching epidemic proportions. PMID:27604528

  16. Anemia of Chronic Liver Diseases

    International Nuclear Information System (INIS)

    Shin, Hyun Chung; Lee, Jhung Sang; Koh, Chang Soon; Lee, Mun Ho

    1971-01-01

    The pathogenetic mechanisms of anemia in patients with chronic liver disease were observed. Seventeen patients with moderate to advanced hepatic diseases were studied by various methods. Only patients without previous blood loss were included : 14 had cirrhosis, 2 had active chronic hepatitis, and one had inferior vena cava obstruction with associated liver cirrhosis. The followings were the results: 1. The anemia based on red blood cell count, Hb., and Ht. was found in 76.5-78.6% of the patients. 2. Red cell indices indicated that normo-macrocytic and normochromic anemia was present is the majority of the patients. 3. No evidence of megaloblastic anemia was found on the basis of the morphological examinations. 4. Serum iron, TIBC, % saturation and iron content in the bone marrow indicated that iron deficiency anemia was present in about half of the patients. 5. In the view of the erythrocyte dynamics, primary increase in the red cell destruction was ascribed to the cause of the anemia. 6. Decrease in the red cell survival time was not correlated with MCV, % saturation and S.L. ratio. Also, hemoglobin level was not correlated with MCV, % saturation and T 50 Cr. Therefore, multiple causes may be involved in the pathogenesis of the anemia. 7. Anemia as determined by the red cell volume was found in only 60% of the patients. It may be possible that hemodilutional anemia is present.

  17. Chronic alcoholism: insights from neurophysiology.

    Science.gov (United States)

    Campanella, S; Petit, G; Maurage, P; Kornreich, C; Verbanck, P; Noël, X

    2009-01-01

    Increasing knowledge of the anatomical structures and cellular processes underlying psychiatric disorders may help bridge the gap between clinical signs and basic physiological processes. Accordingly, considerable insight has been gained in recent years into a common psychiatric condition, i.e., chronic alcoholism. We reviewed various physiological parameters that are altered in chronic alcoholic patients compared to healthy individuals--continuous electroencephalogram, oculomotor measures, cognitive event-related potentials and event-related oscillations--to identify links between these physiological parameters, altered cognitive processes and specific clinical symptoms. Alcoholic patients display: (1) high beta and theta power in the resting electroencephalogram, suggesting hyperarousal of their central nervous system; (2) abnormalities in smooth pursuit eye movements, in saccadic inhibition during antisaccade tasks, and in prepulse inhibition, suggesting disturbed attention modulation and abnormal patterns of prefrontal activation that may stem from the same prefrontal "inhibitory" cortical dysfunction; (3) decreased amplitude for cognitive event-related potentials situated along the continuum of information-processing, suggesting that alcoholism is associated with neurophysiological deficits at the level of the sensory cortex and not only disturbances involving associative cortices and limbic structures; and (4) decreased theta, gamma and delta oscillations, suggesting cognitive disinhibition at a functional level. The heterogeneity of alcoholic disorders in terms of symptomatology, course and outcome is the result of various pathophysiological processes that physiological parameters may help to define. These alterations may be related to precise cognitive processes that could be easily monitored neurophysiologically in order to create more homogeneous subgroups of alcoholic individuals.

  18. Oriental Medical Treatment of chronic Acalculous Cholecystitis

    Directory of Open Access Journals (Sweden)

    Hae-Yeon Lee

    2004-12-01

    Full Text Available Chronic acalculous cholecystitis gets possession of about 12 to 13 percent of patients with chronic cholecystitis. Pathologically it is characterised by chronic inflammation and thickening of the gallbladder wall but doesn't come across stones. Clinical symptoms are vague and include abdominal discomfort and distension, nausea, flatulence and intolerance of fatty foods. A patient on chronic acalculous cholecystitis diagnosed from his clinical symtoms and abdominal ultrasonogram was treated by Geonbihwan, acupuncture and herbal acupuncture. Satisfactory symptomatic improvement was achieved and findings of abdominal ultrasonogram came also normal.

  19. Clinical management of chronic TMD pain.

    Science.gov (United States)

    Miller, D B

    1998-01-01

    Chronic Pain extracts a "penalty" on society now estimated to be well in excess of $100 million per year. The "penalty" that Chronic Pain extracts from its victims is incalculable. Chronic Pain is a major component of Temporomandibular Disorders. The current neurological theory of the mechanism of chronic TMD pain is explored along with the current modes of treatment. Pharmacological management of Chronic Pain in a clinical setting is outlined. Dentists are involved in pain management on a daily basis. Dentists treat pain both prophylacticly and in response to specific patient symptoms. Most dental treatment involves some type of pain management. We, dentists, have become very adept at managing acute pain. We have much greater difficulty managing chronic pain. The word "pain" derives from the Greek word for penalty, and appeared to them to be a "penalty" inflicted by the gods. In 1984, Bonica estimated that one-third of all Americans suffered from some kind of chronic pain at a "penalty" to society of $65 Billion annually in medical expenses and lost wages and productivity. This figure is certainly much greater now. Chronic pain can be a very complex problem that can require a multidisciplinary approach to treatment. Chronic pain in the dental setting is most frequetly caused by prolonged Temporomandibular Disorders.

  20. [Thermometric diagnostics of chronic ulcerous pulpitis].

    Science.gov (United States)

    Zvetkova, P; Mostrova, I

    1989-01-01

    Thermometric measurements were performed of 408 teeth of the upper and lower jaw with clinically confirmed initial and advanced stage of chronic ulcerous pulpitis in 398 subjects, aged from 18 to 30. Temperature elevation within the range from 1.4 to 3.2 degrees C was established in the initial form of chronic pulpitis and from 1 to 2.5 degrees C in advanced form of chronic pulpitis as compared with the norm. Significant difference in the temperature deviations exists in both forms of chronic pulpitis between the teeth of the upper and lower jaw.

  1. Gallstones in Patients with Chronic Liver Diseases

    Directory of Open Access Journals (Sweden)

    Xu Li

    2017-01-01

    Full Text Available With prevalence of 10–20% in adults in developed countries, gallstone disease (GSD is one of the most prevalent and costly gastrointestinal tract disorders in the world. In addition to gallstone disease, chronic liver disease (CLD is also an important global public health problem. The reported frequency of gallstone in chronic liver disease tends to be higher. The prevalence of gallstone disease might be related to age, gender, etiology, and severity of liver disease in patients with chronic liver disease. In this review, the aim was to identify the epidemiology, mechanisms, and treatment strategies of gallstone disease in chronic liver disease patients.

  2. Chronic eosinophilic pneumonia: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Heo, Tae Haeng; Park, Jeong Hee; Lim, Jong Nam; Shin, Hyun Jun; Jeon, Hae Jeong [College of Medicine, Kon-Kuk University, Seoul (Korea, Republic of)

    1995-05-15

    Chronic eosinophilic pneumonia is a rare disease characterized by chronic infiltration of the lung with eosinophils, usually associated with peripheral eosinophilia. In 65% of cases, the chest radiograph shows typical nonsegmental air-space consolidation confined to the outer third of the lung, and in 25% of cases, the 'photographic negative of pulmonary edema' Typical lung manifestations with peripheral eosinophilia are characteristic of chronic eosinophilic pneumonia. In the remaining cases, radiographic findings are nonspecific and require lung biopsy for confirmation. We report a case of chronic eosinophilic pneumonia in which chest radiograph and CT scans revealed bilateral patchy or diffuse opacity with nodules scattered throughout the lungs.

  3. Altered resting state EEG in chronic pancreatitis patients: toward a marker for chronic pain

    NARCIS (Netherlands)

    Vries, M. de; Wilder-Smith, O.H.G.; Jongsma, M.L.A.; Broeke, E.N. van den; Arns, M.W.; Goor, H. van; Rijn, C.M. van

    2013-01-01

    OBJECTIVES: Electroencephalography (EEG) may be a promising source of physiological biomarkers accompanying chronic pain. Several studies in patients with chronic neuropathic pain have reported alterations in central pain processing, manifested as slowed EEG rhythmicity and increased EEG power in

  4. Altered resting state EEG in chronic pancreatitis patients: toward a marker for chronic pain

    NARCIS (Netherlands)

    Vries, M. de; Wilder-Smith, O.H.G.; Jongsma, M.L.A.; Broeke, E.N. van den; Arns, M.W.; Goor, H. van; Rijn, C.M. van

    2013-01-01

    Objectives: Electroencephalography (EEG) may be a promising source of physiological biomarkers accompanying chronic pain. Several studies in patients with chronic neuropathic pain have reported alterations in central pain processing, manifested as slowed EEG rhythmicity and increased EEG power in

  5. E-submission Format for Sub-chronic and Chronic Studies

    Science.gov (United States)

    The purpose of this document is to suggest the format for final reports and to provide instructions for creation of Adobe PDF electronic submission documents for electronic submission of sub-chronic and chronic studies for pesticides.

  6. Chronic saponin treatment attenuates damage to the pancreas in chronic alcohol-treated diabetic rats

    Directory of Open Access Journals (Sweden)

    Mi Ran Choi

    2017-10-01

    Conclusion: Saponin may not only be helpful in alleviating the rapid progress of diabetes due to chronic alcohol consumption in diabetic patients, but may also show potential as an antidiabetic drug candidate for diabetic patients who chronically consume alcohol.

  7. Chronic stunting among under-5 children in Bangladesh: A situation analysis

    Directory of Open Access Journals (Sweden)

    Anwar Islam

    2015-08-01

    Full Text Available Malnutrition is a major problem in many developing countries, including Bangladesh. Chronic malnutrition is a major cause of mortality and morbidity among children under the age of five years. Although Bangladesh has made remarkable progress in reducing mortality in the under-fives, chronic stunting remains a formidable challenge for the country. Based on an analysis of available secondary data, this paper illustrates the current status of chronic stunting in Bangladesh. Data on selected relevant indicators such as gender, urban/rural residence, level of mother’s education, and income by wealth quintiles were extracted from the Bangladesh Health and Demography Surveys from 2004, 2007, and 2011. The data clearly suggest a strong relationship between selected socio-economic variables and stunting among children under the age of five. In rural areas, stunting prevalence rate was found to be more than six times higher than in urban areas. Income inequality was also a significant predictor of stunting. Children from the lowest wealth quintile are twice as likely to be stunted as children from the highest wealth quintile (54% of children under five in the lowest quintile compared to 27% of their counterparts in the highest wealth quintile. Similarly, the level of mother’s education is strongly related to stunting: the higher the level of mothers’ education, the lower the prevalence rate of stunting among children under five. Since wealth or income is a strong predictor of place of residence (urban/rural as well as mothers’ level of education, it can be generally concluded that inequity is the primary determinant of stunting among children under five. Bangladesh must forcefully address inequity in order to tackle the overwhelming prevalence of stunting among children under five. Despite making impressive gains to improve major health and development indicators at the macro level, Bangladesh has so far failed to adequately address the underlying

  8. Chronic depression : Determinants and consequences of chronic major depression in the general population

    NARCIS (Netherlands)

    Spijker, Jan

    2002-01-01

    The subject of this thesis is chronicity of major depressive disorder (MDD). The main aims of the study are to examine: 1. the duration of a major depressive episode (MDE) and the rate of a chronic duration of MDE in the general population, 2. the determinants of (chronic) duration of

  9. Etiological approach to chronic urticaria.

    Science.gov (United States)

    Krupa Shankar, D S; Ramnane, Mukesh; Rajouria, Eliz Aryal

    2010-01-01

    In 1769, William Cullen introduced the word "urticaria" (transient edematous papules, plaque with itching). Urticaria affects 15-25% of people at least once in their life time. It is a clinical reaction pattern triggered by many factors causing the liberation of vasoactive substances such as histamine, prostaglandins and kinins. Urticaria is classified according to its duration into acute (6 weeks duration). Various clinical investigations may be initiated to diagnosis the cause. To evaluate the types of chronic urticaria with reference to etiology from history and investigations. A total of 150 patients with chronic urticaria of more than six weeks were studied. Autologous serum skin test (ASST) was performed after physical urticarias were excluded. Standard batteries of tests were performed after ASST in all patients; and other specific investigations were done where necessary. Skin prick test was done in idiopathic urticaria. The study sample consisted of 62 male and 88 female patients with a mean age of 21-40 years. About 50% of patients showed an ASST positive reaction, 3.9% were positive for antinuclear antibody (ANA), IgE titer was elevated in 37%, H. pylori antibodies was positive in 26.7%. Thyroid antibodies were positive in 6.2%. Giardia and entamoeba histolytica was reported in 3.3% on routine stool examination and on urinalysis 8% had elevated WBC counts; 12% showed para nasal sinusitis, with maxillary sinusitis of 7.3%. Random blood sugar was high in 5.3%. Four patients had ASOM, two had positive KOH mount for dermatophytes, abdominal USG showed cholecystitis in two patients. Recurrent tonsillitis was noted in two patients. Urticaria following intake of NSAIDs was observed in four patients and with oral contraceptive pills in one patient. Contact urticaria to condom (latex) was seen in one patient. Cholinergic (4.7%) and dermographic (4.7%) urticaria were the predominant physical urticarias. Prick test was performed in idiopathic urticaria with maximum

  10. Chronic lead intoxication; Chronische Bleiintoxikation

    Energy Technology Data Exchange (ETDEWEB)

    Wieseler, B.; Leng, G. [Duesseldorf Univ. (Germany). Inst. fuer Hygiene; Lenz, S.; Schultz, C. [Klinikum Remscheid GmbH, Remscheid (Germany); Wilhelm, M. [Bochum Univ. (Germany). Inst. fuer Hygiene, Sozial- und Umweltmedizin

    1999-02-01

    The case of a female 68 years old patient is described. Here, a chronic lead intoxication was diagnosed after a two year old medical history with increasing attacks of colic-like abdominal pain often described as life-threatening. After repeated hospitalizations and intensive search for the cause of the symptoms, porphyria and anemia was found to be a sign of a chronic lead poisoning. The blood lead concentrations were always about a level of 600 {mu}g/L. The source of exposure could not be found by now. Neither home inspection nor environmental investigations have shown a recent source of lead intake by the patient. However, a possible occupational source of lead exposure at a blast furnace was established by anamnesis for 1952 to 1962. Thus, osteoporosis induced lead mobilisation was suspected. Noticeable are the results of the six abdominal survey radiographies taken during hospitalization within one year; three radiographies were taken following clinical admission and three before discharge of the patient. In comparison, the course shows a chronic relapsing alimentary supply from metallic particles of unknown genesis. The patient was treated with the sodium salt of 2,3-dimercapto-1-propansulfonic acid (DMPS, Dimaval{sup TM}). She was free of complain afterwards. Following therapy, the blood lead concentrations fell under a level of 400 {mu}m/L, but after several weeks the lead level raised up to the original level of 600 {mu}g/L. (orig.) [Deutsch] Es wird eine 68jaehrige Patientin vorgestellt, bei der nach fast zweijaehriger Krankengeschichte, die gekennzeichnet war durch rezidivierende, teils als lebensbedrohlich geschilderte Bauchkoliken, eine chronische Bleiintoxikation diagnostiziert wurde. Erst nach wiederholten stationaeren Krankenhausaufenthalten mit intensiver Suche nach der Krankheitsursache wurden das Krankheitsbild und die Laborwerte durch Zusatzuntersuchungen ergaenzt, so dass sich in der festgestellten Porphyrie und Anaemie die Diagnose der

  11. Chronic Obstructive Pulmonary Disease Biomarkers

    Directory of Open Access Journals (Sweden)

    Tatsiana Beiko

    2016-04-01

    Full Text Available Despite significant decreases in morbidity and mortality of cardiovascular diseases (CVD and cancers, morbidity and cost associated with chronic obstructive pulmonary disease (COPD continue to be increasing. Failure to improve disease outcomes has been related to the paucity of interventions improving survival. Insidious onset and slow progression halter research successes in developing disease-modifying therapies. In part, the difficulty in finding new therapies is because of the extreme heterogeneity within recognized COPD phenotypes. Novel biomarkers are necessary to help understand the natural history and pathogenesis of the different COPD subtypes. A more accurate phenotyping and the ability to assess the therapeutic response to new interventions and pharmaceutical agents may improve the statistical power of longitudinal clinical studies. In this study, we will review known candidate biomarkers for COPD, proposed pathways of pathogenesis, and future directions in the field.

  12. Etiological approach to chronic urticaria

    Directory of Open Access Journals (Sweden)

    Krupa Shankar D

    2010-01-01

    Full Text Available Background: In 1769, William Cullen introduced the word "urticaria" (transient edematous papules, plaque with itching. Urticaria affects 15-25% of people at least once in their life time. It is a clinical reaction pattern triggered by many factors causing the liberation of vasoactive substances such as histamine, prostaglandins and kinins. Urticaria is classified according to its duration into acute (< 6 weeks duration and chronic (>6 weeks duration. Various clinical investigations may be initiated to diagnosis the cause. Aims: To evaluate the types of chronic urticaria with reference to etiology from history and investigations . Materials and Methods: A total of 150 patients with chronic urticaria of more than six weeks were studied. Autologous serum skin test (ASST was performed after physical urticarias were excluded. Standard batteries of tests were performed after ASST in all patients; and other specific investigations were done where necessary. Skin prick test was done in idiopathic urticaria. Results: The study sample consisted of 62 male and 88 female patients with a mean age of 21-40 years. About 50% of patients showed an ASST positive reaction, 3.9% were positive for antinuclear antibody (ANA, IgE titer was elevated in 37%, H. pylori antibodies was positive in 26.7%. Thyroid antibodies were positive in 6.2%. Giardia and entamoeba histolytica was reported in 3.3% on routine stool examination and on urinalysis 8% had elevated WBC counts; 12% showed para nasal sinusitis, with maxillary sinusitis of 7.3%. Random blood sugar was high in 5.3%. Four patients had ASOM, two had positive KOH mount for dermatophytes, abdominal USG showed cholecystitis in two patients. Recurrent tonsillitis was noted in two patients. Urticaria following intake of NSAIDs was observed in four patients and with oral contraceptive pills in one patient. Contact urticaria to condom (latex was seen in one patient. Cholinergic (4.7% and dermographic (4.7% urticaria were

  13. Urban factor in chronic bronchitis

    Energy Technology Data Exchange (ETDEWEB)

    Holland, W W; Reid, D D

    1965-01-01

    A questionnaire and lung function survey were conducted of groups of van drivers employed either in central London or in 3 rural English towns. Consistent with similar studies, urban/rural respiratory morbidity gap was prominent, even after accounting for smoking, socio-economic class, physique, and occupation. Other major variable was air pollution. Smoking exacerbated symptoms. Londoners had lower peak flow rate, lower FEV/sub 1/ /sub 0/, greater incidence of symptoms of chronic bronchitis, greater proportion of purulent sputum, and greater incidence of cough. Differences accentuated in men aged 50 and older. Differences in some variables between urban and rural areas (e.g., cough) show little effect of air pollution on non-smokers.

  14. Looking after chronically ill dogs

    DEFF Research Database (Denmark)

    Christiansen, Stine B.; Kristensen, Annemarie Thuri; Sandøe, Peter

    2013-01-01

    thus face similar challenges when caring for their animals. This qualitative study uncovers impacts on an owner's life, when attending to the care of an aged or chronically ill dog and reflects on the differing roles of caregivers with animal and human patients. Twelve dog owners were selected for in......-depth interviews based on the dogs' diagnoses, and the choice of treatments and care expected to affect the owner's life. Interviews were recorded, transcribed, and analyzed qualitatively. The dog owners reported several changes in their lives due to their dog's condition: practicalities like extra care, changes...... in use of the home, and restrictions relating to work, social life, and finances. These were time-consuming, tough, and annoying, but could often be dealt with through planning and prioritizing. Changes in the human–dog relationship and activities caused sadness and frustration, which in turn led...

  15. Chronic lung disease in newborns.

    Science.gov (United States)

    Sankar, M Jeeva; Agarwal, Ramesh; Deorari, Ashok K; Paul, Vinod K

    2008-04-01

    Chronic lung disease (CLD) or bronchopulmonary dysplasia (BPD) occurs in preterm infants who require respiratory support in the first few days of birth. Apart from prematurity, oxygen therapy and assisted ventilation, factors like intrauterine/postnatal infections, patent ductus arteriosus, and genetic polymorphisms also contribute to its pathogenesis. The severe form of BPD with extensive inflammatory changes is rarely seen nowadays; instead, a milder form characterized by decreased alveolar septation due to arrest in lung development is more common. A multitude of strategies, mainly pharmacological and ventilatory, have been employed for prevention and treatment of BPD. Unfortunately, most of them have not been proved to be beneficial. A comprehensive protocol for management of BPD based on the current evidence is discussed here.

  16. Chronic recurrent multifocal osteomyelitis (CRMO)

    International Nuclear Information System (INIS)

    Schilling, F.

    1998-01-01

    Chronic recurrent multifocal osteomyelitis (CRMO) is an unusual clinical entity. More than 200 cases are described in the literature and it is presented here with special reference to its radiological aspects. It is an acquired disease of the skeleton which occurs predominantly during childhood and adolescence. About ten per cent of cases begin in early or, rarely, in later adult life. This variant is described here for the first time and is discussed as 'adult CRMO'. The underlying pathology is a bland, predominantly lympho-plasma cellular osteomyelitis which is self-limiting and leads to bone sclerosis (Garre). It probably involves an abnormal immune process which follows an infection but remains clinically latent and remains aseptic and sterile. In a quarter of cases there is an association with pustulosis palmo-plantaris and its relationship with psoriatic arthropathy is discussed. The clinical, histopathological and imaging features (radiological and particularly MRT) and the bone changes are described. (orig./AJ) [de

  17. Personalized Support for Chronic Conditions

    Science.gov (United States)

    D’Antrassi, Pierluigi; Ajčević, Miloš; Stellato, Kira; Di Lenarda, Andrea; Marceglia, Sara; Accardo, Agostino

    2016-01-01

    Summary Objective Solutions for improving management of chronic conditions are under the attention of healthcare systems, due to the increasing prevalence caused by demographic change and better survival, and the relevant impact on healthcare expenditures. The objective of this study was to propose a comprehensive architecture of a mHealth system aimed at boosting the active and informed participation of patients in their care process, while at the same time overcoming the current technical and psychological/clinical issues highlighted by the existing literature. Methods After having studied the current challenges outlined in the literature, both in terms of technological and human requirements, we focused our attention on some specific psychological aspects with a view to providing patients with a comprehensive and personalized solution. Our approach has been reinforced through the results of a preliminary assessment we conducted on 22 patients with chronic conditions. The main goal of such an assessment was to provide a preliminary understanding of their needs in a real context, both in terms of self-awareness and of their predisposition toward the use of IT solutions. Results According to the specific needs and features, such as mindfulness and gamification, which were identified through the literature and the preliminary assessment, we designed a comprehensive open architecture able to provide a tailor-made solution linked to specific individuals’ needs. Conclusion The present study represents the preliminary step towards the development of a solution aimed at enhancing patients’ actual perception and encouraging self-management and self-awareness for a better lifestyle. Future work regards further identification of pathology-related needs and requirements through focus groups including all stakeholders in order to describe the architecture and functionality in greater detail. PMID:27452661

  18. Chronic lead intoxication in calves

    Energy Technology Data Exchange (ETDEWEB)

    Wagenaar, G

    1963-01-01

    Four calves born in the winter of 1961-1962 died on a farm after a disease which had run its course for periods ranging from six weeks to a few months. A calf had also died showing similar symptoms during the previous year. All calves showed identical symptoms. Initially, their liveliness diminished; subsequently, they drank less and showed signs of pica. They finally died after the disease had run its course for about six weeks. The last calf, born late in February 1962, was in poor health as early as May, improved slightly when it had been sent out to grass but died in September, having fallen ill again in August. Autopsy was performed on three calves; all three were affected with chronic interstitial nephritis and uraemic endocarditis of the left auricle was present as well. The results obtained on toxicological investigation were indicative of lead poisoning. The liver of the calf was found to contain two mg of lead per kg, the cortex of the kidney containing twenty-five mg of lead per kg. These figures did not provide direct evidence of lead poisoning, but in evaluating these figures the fact was taken into account that the calf had no longer been able to ingest any lead for several months. Meanwhile, it was found that the stock-owner had fitted an old painted door in the calf-shed, which door was constantly being licked by the calves. The paint contained 18.6% of lead. This finding was followed by examination of the liver of a calf that had died previously. It was found to contain 49.7 mg of lead per kg. Accordingly, the calves had been affected with a form of lead poisoning running a relatively slow course, as a result of which the animals had developed chronic interstitial nephritis. The calves eventually died from uraemia. 4 references.

  19. Chronic necrotising pneumonia caused by Aspergillus niger.

    Science.gov (United States)

    Wiggins, J; Clark, T J; Corrin, B

    1989-01-01

    A woman with asthma developed chronic necrotising semi-invasive pneumonia due to mixed Aspergillus niger and Candida albicans infection; though not severely immunosuppressed, she may have been predisposed by long term oral corticosteroid and recurrent oral antibiotic treatment. The diagnosis should be considered in patients with chronic airflow limitation who develop cavitating pneumonia. Images PMID:2763249

  20. The Danish National Chronic Lymphocytic Leukemia Registry

    DEFF Research Database (Denmark)

    da Cunha-Bang, Caspar; Geisler, Christian Hartmann; Enggaard, Lisbeth

    2016-01-01

    AIM: In 2008, the Danish National Chronic Lymphocytic Leukemia Registry was founded within the Danish National Hematology Database. The primary aim of the registry is to assure quality of diagnosis and care of patients with chronic lymphocytic leukemia (CLL) in Denmark. Secondarily, to evaluate...

  1. Genetics Home Reference: chronic myeloid leukemia

    Science.gov (United States)

    ... Central Quintás-Cardama A, Cortes JE. Chronic myeloid leukemia: diagnosis and treatment. Mayo Clin Proc. 2006 Jul;81(7):973-88. Review. Citation on PubMed Skorski T. Genetic mechanisms of chronic myeloid leukemia blastic transformation. Curr Hematol Malig Rep. 2012 Jun; ...

  2. Danish Register of chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Lange, Peter; Tøttenborg, Sandra Søgaard; Sorknæs, Anne Dichmann

    2016-01-01

    AIM OF DATABASE: The Danish Register of Chronic Obstructive Pulmonary Disease (DrCOPD) is a nationwide database aiming to describe the quality of treatment of all patients with chronic obstructive pulmonary disease (COPD) in Denmark. STUDY POPULATION: DrCOPD comprises data on all patients...

  3. Natural histories of chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Rennard, Stephen I; Vestbo, Jørgen

    2008-01-01

    Concepts relating to the natural history of chronic obstructive pulmonary disease (COPD) arise most importantly from the classic study of Fletcher and colleagues (The Natural History of Chronic Bronchitis and Emphysema, Oxford University Press, New York, 1976). This study, which evaluated working...

  4. Osteoporosis in chronic obstructive pulmonary disease patients

    DEFF Research Database (Denmark)

    Jørgensen, Niklas Rye; Schwarz, Peter

    2008-01-01

    The purpose of this review is to examine the state of knowledge and clinical practice in the association of chronic obstructive pulmonary disease to osteoporosis and fracture incidence.......The purpose of this review is to examine the state of knowledge and clinical practice in the association of chronic obstructive pulmonary disease to osteoporosis and fracture incidence....

  5. Underlying causes of chronic bladder dysfunction

    African Journals Online (AJOL)

    It is often associated with other chronic pain conditions such as chronic functional ... a safe and effective option for treating IC/PBS.10 Proposed future research approaches include systemic treatment with anti-nerve growth factors .... polyethylene or arylamine derivatives) may contribute towards developing transitional cell ...

  6. Management of chronic hepatitis Band C

    African Journals Online (AJOL)

    disorders must be excluded. Serum copper, urinary copper ... storage diseases and a,-antitrypsin deficiency. ... s absent, the specimen should be sent to a centre of excellence for .... Drug-induced chronic liver disease with emphasis on chronic active hepatitis. ..... interferon represent a difficult management problem. Lower.

  7. Urea synthesis in patients with chronic pancreatitis

    DEFF Research Database (Denmark)

    Hamberg, Ole; Andersen, Vibeke; Sonne, J

    2001-01-01

    Up-regulation of urea synthesis by amino acids and dietary protein intake may be impaired in patients with chronic pancreatitis (CP) due to the reduced glucagon secretion. Conversely, urea synthesis may be increased as a result of the chronic inflammation. The aims of the study were to determine...

  8. Recurrent otorrhea in chronic suppurative otitis media

    DEFF Research Database (Denmark)

    Jensen, Ramon Gordon; Johansen, Helle Krogh; Bjarnsholt, Thomas

    2017-01-01

    Dispersal of bacteria from a biofilm in the middle ear, serving as a bacterial reservoir, could explain the recurrent and chronic nature of chronic suppurative otitis media (CSOM). The objective of this study is to investigate if the same strains of bacteria could be detected in repeated episodes...

  9. Major and chronic diseases, report 2007.

    NARCIS (Netherlands)

    Giampaoli, S.; Oyen, H. van; Devillé, W.; Verschuuren, M.

    2008-01-01

    Blind spots in European health information On June 6th 2008 the European Commission has published the Major and Chronic Diseases Report 2007. This report describes the state of the art of health information in Europe on 13 prevalent chronic conditions. Large differences between the Member States of

  10. Genetics Home Reference: chronic granulomatous disease

    Science.gov (United States)

    ... Other common areas of infection in people with chronic granulomatous disease include the skin, liver , and lymph nodes . Inflammation can occur in ... Other common areas of inflammation in people with chronic granulomatous ... and skin. Additionally, granulomas within the gastrointestinal tract can lead ...

  11. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Diagnosis

    Science.gov (United States)

    ... Controls Search Form Controls Cancel Submit Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Note: Javascript is disabled or is not supported ... Facebook Tweet Share Compartir To diagnose myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a patient’s doctor or healthcare provider ...

  12. New treatment of chronic hepatitis B

    DEFF Research Database (Denmark)

    Andersen, E.S.; Weis, Nina

    2008-01-01

    Worldwide, 350 million people are infected with chronic hepatitis B. Over the last few years, it has been possible to treat chronic hepatitis B. Treatment very often consists of nucleos(t)ide analogs and in a few cases of pegylated alpha-interferon. In 2007, a new nucleoside analog, Telbivudine...

  13. [Adaptation strategies faced with chronic pain].

    Science.gov (United States)

    Bioy, Antoine

    2017-05-01

    Chronic pain constitutes a challenge for patients. It makes them uneasy with regard to their personality, their corporality and their life balance, and leaves long-lasting effects on their experience as a patient. The development of adaptation strategies and resources to deal with chronic pain is therefore essential. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  14. Protein restriction in chronic renal failure

    NARCIS (Netherlands)

    ECHTEN, JEKT; NAUTA, J; HOP, WCJ; de Jong, MCJ; REITSMABIERENS, WCC; VANAMSTEL, SLBP; VANACKER, KJ; NOORDZIJ, CM; WOLFF, ED

    The aim of the study was to investigate the effect of a protein restricted diet on renal function and growth of children with chronic renal failure. In a multicentre prospective study 56 children (aged 2-18 years) with chronic renal failure were randomly assigned to the protein restricted (0.8-1.1

  15. Reported barriers to evaluation in chronic care

    DEFF Research Database (Denmark)

    Knai, Cécile; Nolte, Ellen; Brunn, Matthias

    2013-01-01

    The growing movement of innovative approaches to chronic disease management in Europe has not been matched by a corresponding effort to evaluate them. This paper discusses challenges to evaluation of chronic disease management as reported by experts in six European countries....

  16. Chronic rhinosinusitis: correlation of symptoms with computed ...

    African Journals Online (AJOL)

    Introduction: Symptomatology, nasal endoscopy and Computerised Tomographic (CT) scan have been used to diagnose chronic rhinosinusitis. The value of disease severity score in the assessment of chronic rhinosinusitis has not been well investigated. Hence, this study aims to correlate the pre-operative symptom ...

  17. Fisetin and Its Role in Chronic Diseases.

    Science.gov (United States)

    Pal, Harish C; Pearlman, Ross L; Afaq, Farrukh

    2016-01-01

    Chronic inflammation is a prolonged and dysregulated immune response leading to a wide variety of physiological and pathological conditions such as neurological abnormalities, cardiovascular diseases, diabetes, obesity, pulmonary diseases, immunological diseases, cancers, and other life-threatening conditions. Therefore, inhibition of persistent inflammation will reduce the risk of inflammation-associated chronic diseases. Inflammation-related chronic diseases require chronic treatment without side effects. Use of traditional medicines and restricted diet has been utilized by mankind for ages to prevent or treat several chronic diseases. Bioactive dietary agents or "Nutraceuticals" present in several fruits, vegetables, legumes, cereals, fibers, and certain spices have shown potential to inhibit or reverse the inflammatory responses and several chronic diseases related to chronic inflammation. Due to safe, nontoxic, and preventive benefits, the use of nutraceuticals as dietary supplements or functional foods has increased in the Western world. Fisetin (3,3',4',7-tetrahydroxyflavone) is a dietary flavonoid found in various fruits (strawberries, apples, mangoes, persimmons, kiwis, and grapes), vegetables (tomatoes, onions, and cucumbers), nuts, and wine that has shown strong anti-inflammatory, anti-oxidant, anti-tumorigenic, anti-invasive, anti-angiogenic, anti-diabetic, neuroprotective, and cardioprotective effects in cell culture and in animal models relevant to human diseases. In this chapter, we discuss the beneficial pharmacological effects of fisetin against different pathological conditions with special emphasis on diseases related to chronic inflammatory conditions.

  18. Chronic bronchitis in an elderly population

    DEFF Research Database (Denmark)

    Lange, Peter; Parner, Jan; Prescott, Eva

    2003-01-01

    in order to describe the prevalence and prognostic implications of chronic bronchitis in individuals 65 years or older we analysed data from The Copenhagen City Heart Study.......in order to describe the prevalence and prognostic implications of chronic bronchitis in individuals 65 years or older we analysed data from The Copenhagen City Heart Study....

  19. Laparoscopic Cholecystectomy in Chronic Calculus Cholecystitis

    Directory of Open Access Journals (Sweden)

    Prakash Sapkota

    2013-12-01

    Full Text Available Introduction: Laparoscopic cholecystectomy has clearly become the choice over open cholecystectomy in the treatment of hepatobiliary disease since its introduction by Mouret in 1987. This study evaluates a series of patients with chronic calculus cholecystitis who were treated with laparoscopic and open cholecystectomy and assesses the outcomes of both techniques. Objective: To evaluate the efficacy of laparoscopic vs open cholecystectomy in chronic calculus cholecystitis and establish the out-comes of this treatment modality at Lumbini Medical College and Teaching Hospital. Methods: This was a retrospective analysis over a one-year period (January 1, 2012 to December 31, 2012, per-formed by single surgeon at Lumbini Medical College and Teaching Hospital located midwest of Nepal. 166 patients underwent surgical treatment for chronic calculus cholecystitis. Patients included were only chronic calculus cholecystitis proven histopathologocally and the rest were excluded. Data was collected which included patients demographics, medical history, presentation, complications, conversion rates from laparoscopic. cholecystectomy to open cholecystectomy, operative and postoperative time. Results: Patients treated with laparoscopic cholecystectomy for chronic calculus cholecystitis had shorter operating times and length of stay compared to patients treated with open cholecystectomy for chronic calculus cholecystitis. Conversion rates were 3.54% in chronic calculus cholecystitis during the study period. Complications were also lower in patients who underwent laparoscopic cholecystectomy versus open cholecystectomy for cholelithiasis. Conclusions: Laparoscopic cholecystectomy appears to be a reliable, safe, and cost-effective treatment modality for chronic calculus cholecystitis.

  20. Tailoring Self-Management in Chronic Care

    NARCIS (Netherlands)

    Touwen, ID

    2016-01-01

    Self-management is nowadays seen as an important element in chronic care and therefore, self-management is increasingly embedded in chronic care guidelines; however, implementation in clinical practice is a slow and difficult process. Evidence, from research on self-management interventions, shows

  1. Clinical monitoring of 'autoimmune' chronic active hepatitis

    NARCIS (Netherlands)

    Hoek, Bart van

    1989-01-01

    This thesis describes the outcome- survival of a large group of 186 consecutive patients with chronic active hepatitis of variouse tiologies, and describes in detail the progress of 21 patients from this group with 'autoimmunie' chronic active hepatitis maintained on standardized immunosuppressive

  2. Syndrome Analysis: Chronic Alcoholism in Adults.

    Science.gov (United States)

    Pendorf, James E.

    1990-01-01

    Provides outline narrative of most possible outcomes of regular heavy alcohol use, regular alcohol abuse, or chronic alcoholism. A systems analysis approach is used to expose conditions that may result when a human organism is subjected to excessive and chronic alcohol consumption. Such an approach illustrates the detrimental effects which alcohol…

  3. Ribavirin monotherapy for chronic hepatitis C infection

    DEFF Research Database (Denmark)

    Brok, Jesper; Gluud, Lise L; Gluud, Christian

    2006-01-01

    Adding ribavirin to interferon improves treatment response for patients with chronic hepatitis C, but the effects of ribavirin monotherapy are unclear. We conducted a systematic review to assess the benefits and harms of ribavirin monotherapy for patients with chronic hepatitis C....

  4. [Chronic pancreatitis: new definition and perspectives.

    Science.gov (United States)

    Conti Bellocchi, Maria Cristina; De Pretis, Nicolò; Amodio, Antonio; Zerbi, Alessandro; Frulloni, Luca

    2018-01-01

    Chronic pancreatitis has been considered over the past years as a single disease, alcohol-induced and different from acute pancreatitis, in terms of etiology and prognosis. Actually, the introduction of a new concept of chronic pancreatitis, now considered as a fibroinflammatory process caused by multiple factors (toxic-metabolic, genetic, immunologic, obstructive), allow to better understand the pathogenesis of this complex disease. Furthermore, the discover of peculiar forms of chronic pancreatitis (autoimmune, paraduodenal, associated to gene mutations), different in term of clinical aspects, findings at imaging, prognosis and therapy, radically changed the concept of the disease. In this brief review, we described the impact of this new concept in the comprehension of pathogenesis, in the definition of peculiar forms of chronic pancreatitis, and in the clinical and therapeutic approach of chronic pancreatitis.

  5. Imaging in the diagnosis of chronic pancreatitis

    Directory of Open Access Journals (Sweden)

    Vasile D. Balaban

    2014-12-01

    Full Text Available Chronic pancreatitis is characterised by progressive and irreversible damage of the pancreatic parenchyma and ductal system, which leads to chronic pain, loss of endocrine and exocrine functions. Clinically, pancreatic exocrine insufficiency becomes apparent only after 90% of the parenchima has been lost. Despite the simple definition, diagnosing chronic pancreatitis remains a challenge, especially for early stage disease. Because pancreatic function tests can be normal until late stages and have significant limitations, there is an incresing interest in the role of imaging techniques for the diagnosis of chronic pancreatitis. In this article we review the utility and accuracy of different imaging methods in the diagnosis of chronic pancreatitis, focusing on the role of advanced imaging (magnetic resonance imaging, endoscopic retrograde cholangiopancreatography and endoscopic ultrasound.

  6. Management of chronic unstable acromioclavicular joint injuries.

    Science.gov (United States)

    Cisneros, Luis Natera; Reiriz, Juan Sarasquete

    2017-12-01

    The acromioclavicular joint represents the link between the clavicle and the scapula, which is responsible for the synchronized dynamic of the shoulder girdle. Chronic acromioclavicular joint instability involves changes in the orientation of the scapula, which provokes cinematic alterations that might result in chronic pain. Several surgical strategies for the management of patients with chronic and symptomatic acromioclavicular joint instability have been described. The range of possibilities includes anatomical and non-anatomical techniques, open and arthroscopy-assisted procedures, and biological and synthetic grafts. Surgical management of chronic acromioclavicular joint instability should involve the reconstruction of the torn ligaments because it is accepted that from three weeks after the injury, these structures may lack healing potential. Here, we provide a review of the literature regarding the management of chronic acromioclavicular joint instability. Expert opinion, Level V.

  7. HIV/AIDS, chronic diseases and globalisation.

    Science.gov (United States)

    Colvin, Christopher J

    2011-08-26

    HIV/AIDS has always been one of the most thoroughly global of diseases. In the era of widely available anti-retroviral therapy (ART), it is also commonly recognised as a chronic disease that can be successfully managed on a long-term basis. This article examines the chronic character of the HIV/AIDS pandemic and highlights some of the changes we might expect to see at the global level as HIV is increasingly normalised as "just another chronic disease". The article also addresses the use of this language of chronicity to interpret the HIV/AIDS pandemic and calls into question some of the consequences of an uncritical acceptance of concepts of chronicity.

  8. Genetics Home Reference: PDGFRB-associated chronic eosinophilic leukemia

    Science.gov (United States)

    ... associated chronic eosinophilic leukemia PDGFRB-associated chronic eosinophilic leukemia Printable PDF Open All Close All Enable Javascript ... expand/collapse boxes. Description PDGFRB -associated chronic eosinophilic leukemia is a type of cancer of blood-forming ...

  9. Psychological Characteristics of Chronic Depression : A Longitudinal Cohort Study

    NARCIS (Netherlands)

    Wiersma, Jenneke E.; van Oppen, Patricia; van Schaik, Digna J. F.; van der Does, A. J. Willem; Beekman, Aartjan T. E.; Penninx, Brenda W. J. H.

    Background: Few studies have investigated the importance of psychological characteristics for chronicity of depression. Knowledge about psychological differences between chronically depressed persons and nonchronically depressed persons may help to improve treatment of chronic depression. This is

  10. Review of occupational therapy for people with chronic pain.

    LENUS (Irish Health Repository)

    Robinson, Katie

    2011-04-01

    Chronic pain is a significant health-care problem. This review aims to critically analyse occupational therapy services for people with chronic pain and identify significant factors influencing the future development of occupational therapy services for people with chronic pain.

  11. SERUM IRON PARAMETERS IN ALCOHOLIC CIRRHOSIS, CRYPTOGENIC CIRRHOSIS, CHRONIC HEPATITIS B AND CHRONIC HEPATITIS C

    Directory of Open Access Journals (Sweden)

    Sajeevan K. C

    2016-11-01

    Full Text Available BACKGROUND Regular monitoring of serum iron parameters is helpful for assessing the severity of alcoholic liver disease. Assessment of serum iron parameters are used for screening hereditary haemochromatosis in chronic liver disease. Serum iron parameters in chronic liver disease have not been clearly described in most of the studies. The aim of this study was to assess the serum iron, Total Iron Binding Capacity (TIBC, transferrin saturation and ferritin levels in common chronic liver disease like alcoholic cirrhosis, cryptogenic cirrhosis, chronic hepatitis C and chronic hepatitis B. MATERIALS AND METHODS 110 consecutive patients with chronic liver disease admitted to the Gastroenterology Department, Government Medical College, Kozhikode were selected for the study. The categories of chronic liver disease included in our study were alcoholic cirrhosis (Group I, n = 40, cryptogenic cirrhosis (Group II, n = 30, chronic hepatitis C (Group III, n = 20 and chronic hepatitis B (Group IV, n = 20. Serum iron, ferritin, total iron binding capacity and transferrin saturation were estimated in the fasting sample. Statistical Analysis- Analysis was performed using nonparametric Kruskal-Wallis and Bonferroni test to assess statistical significance of difference of continuous variables among and between groups, respectively. The results were considered statistically significant at the level of p <0.05. RESULTS The serum iron level was normal and total iron binding capacity was low in all the four groups of chronic liver disease. Serum ferritin and transferrin saturation were significantly higher in alcoholic cirrhosis in comparison with cryptogenic cirrhosis and chronic hepatitis B, but was not statistically significant in comparison with chronic hepatitis C. CONCLUSION We observed irregularities in iron status in patients with alcoholic cirrhosis, cryptogenic cirrhosis, chronic hepatitis C and chronic hepatitis B.

  12. Discharge Planning in Chronic Conditions

    Science.gov (United States)

    McMartin, K

    2013-01-01

    Background Chronically ill people experience frequent changes in health status accompanied by multiple transitions between care settings and care providers. Discharge planning provides support services, follow-up activities, and other interventions that span pre-hospital discharge to post-hospital settings. Objective To determine if discharge planning is effective at reducing health resource utilization and improving patient outcomes compared with standard care alone. Data Sources A standard systematic literature search was conducted for studies published from January 1, 2004, until December 13, 2011. Review Methods Reports, randomized controlled trials, systematic reviews, and meta-analyses with 1 month or more of follow-up and limited to specified chronic conditions were examined. Outcomes included mortality/survival, readmissions and emergency department (ED) visits, hospital length of stay (LOS), health-related quality of life (HRQOL), and patient satisfaction. Results One meta-analysis compared individualized discharge planning to usual care and found a significant reduction in readmissions favouring individualized discharge planning. A second meta-analysis compared comprehensive discharge planning with postdischarge support to usual care. There was a significant reduction in readmissions favouring discharge planning with postdischarge support. However, there was significant statistical heterogeneity. For both meta-analyses there was a nonsignificant reduction in mortality between the study arms. Limitations There was difficulty in distinguishing the relative contribution of each element within the terms “discharge planning” and “postdischarge support.” For most studies, “usual care” was not explicitly described. Conclusions Compared with usual care, there was moderate quality evidence that individualized discharge planning is more effective at reducing readmissions or hospital LOS but not mortality, and very low quality evidence that it is more

  13. Integration of healthcare rehabilitation in chronic conditions

    Directory of Open Access Journals (Sweden)

    Anne Frølich

    2010-02-01

    Full Text Available Introduction: Quality of care provided to people with chronic conditions does not often fulfil standards of care in Denmark and in other countries. Inadequate organisation of healthcare systems has been identified as one of the most important causes for observed performance inadequacies, and providing integrated healthcare has been identified as an important organisational challenge for healthcare systems. Three entities—Bispebjerg University Hospital, the City of Copenhagen, and the GPs in Copenhagen—collaborated on a quality improvement project focusing on integration and implementation of rehabilitation programmes in four conditions. Description of care practice: Four multidisciplinary rehabilitation intervention programmes, one for each chronic condition: chronic obstructive pulmonary disease, type 2 diabetes, chronic heart failure, and falls in elderly people were developed and implemented during the project period. The chronic care model was used as a framework for support of implementing and integration of the four rehabilitation programmes. Conclusion and discussion: The chronic care model provided support for implementing rehabilitation programmes for four chronic conditions in Bispebjerg University Hospital, the City of Copenhagen, and GPs' offices. New management practices were developed, known practices were improved to support integration, and known practices were used for implementation purposes. Several barriers to integrated care were identified.

  14. Etiologies of chronic liver disease in children

    Directory of Open Access Journals (Sweden)

    Farahmand F

    2001-11-01

    Full Text Available Chronic Liver diseases in children is the result of many different diseases including: metabolic, genetic, infectious, toxic and idiopathic causes. This was a case series study on 133 infants and children with age range 6 month to 12 years old, who presented clinically with manifestation of chronic liver disease and were admitted to Children Hospital Medical Center from year 1999 to 2000. In this study, 32 (24.5 percent patients had autoimmune chronic hepatitis, 15 (11.3 percent Glycogen storage diseases, 12 (9 percent extrahepatic biliary atresia, 11 (8.2 percent willson disease, 10 (7.5 percent cryptogenic cirrhosis, 6 (4.5 percent chronic hepatitis C, 5 (3.8 percen chronic hepatitic B, 5 (3.8 percent galactosemia 3 (2.25 percent congenital hepatic fibrosis, 3 (3.8 percent histiocytosis X, 3 (2.25 percent sclerosing cholangitis, 2 (1.5 percent byler’s disease 2 (1.5 percent primary tuberculosis, 1 (0.75 percent choledocalcyst, 1 (0.75 percent Alagyle syndrome. According to our data, chronic liver disease should be considered in infants and children. In our study, the most common causes are found to be: metabolic and genetic diseases (37.5 percent, chronic autoimmune hepatitis (24 percent and biliary disorders (14 percent, that encompass 86 percent of the patients.

  15. Hostility and Anger in Chronic Pain

    Directory of Open Access Journals (Sweden)

    Sara Oliveira

    2013-11-01

    Full Text Available Introduction: The affective component of pain incorporates various emotions, primarily negative in quality. A great emphasis has been traditionally given to the role of depression and anxiety in chronic pain. More recently, the focus has been directed towards hostility and anger, as fundamental components of the emotional experience of chronic pain. Objective: The aim of this article is to present a literature’s review about the association between chronic pain, anger and hostility. Discussion: Patients with several chronic disorders are characterized by high levels of trait anger and hostility. On the other hand, the manner in which angry feelings are typically handled (anger management style, especially the marked tendency to suppress or express angry feelings, is a particularly important determinant of the chronic pain severity. Conclusion: Hostility and anger are involved in the development, maintenance and treatment of chronic pain. Further research is needed to clarify its relationship with chronic pain and to evaluate the effects of anger management on treatment outcomes.

  16. Hostility and Anger in Chronic Pain

    Directory of Open Access Journals (Sweden)

    Lúcia Ribeiro

    2012-06-01

    Full Text Available Introduction: The affective component of pain incorporates various emotions, primarily negative in quality. A great emphasis has been traditionally given to the role of depression and anxiety in chronic pain. More recently, the focus has been directed towards hostility and anger, as fundamental components of the emotional experience of chronic pain. Objective: The aim of this article is to present a literature’s review about the association between chronic pain, anger and hostility. Discussion: Patients with several chronic disorders are characterized by high levels of trait anger and hostility. On the other hand, the manner in which angry feelings are typically handled (anger management style, especially the marked tendency to suppress or express angry feelings, is a particularly important determinant of the chronic pain severity. Conclusion: Hostility and anger are involved in the development, maintenance and treatment of chronic pain. Further research is needed to clarify its relationship with chronic pain and to evaluate the effects of anger management on treatment outcomes.

  17. Chronic disease as risk multiplier for disadvantage.

    Science.gov (United States)

    Stutzin Donoso, Francisca

    2018-03-06

    This paper starts by establishing a prima facie case that disadvantaged groups or individuals are more likely to get a chronic disease and are in a disadvantaged position to adhere to chronic treatment despite access through Universal Health Coverage. However, the main aim of this paper is to explore the normative implications of this claim by examining two different but intertwined argumentative lines that might contribute to a better understanding of the ethical challenges faced by chronic disease health policy. The paper develops the argument that certain disadvantages which may predispose to illness might overlap with disadvantages that may hinder self-management, potentially becoming disadvantageous in handling chronic disease. If so, chronic diseases may be seen as disadvantages in themselves, describing a reproduction of disadvantage among the chronically ill and a vicious circle of disadvantage that could both predict and shed light on the catastrophic health outcomes among disadvantaged groups-or individuals-dealing with chronic disease. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  18. Brain morphological signatures for chronic pain.

    Directory of Open Access Journals (Sweden)

    Marwan N Baliki

    Full Text Available Chronic pain can be understood not only as an altered functional state, but also as a consequence of neuronal plasticity. Here we use in vivo structural MRI to compare global, local, and architectural changes in gray matter properties in patients suffering from chronic back pain (CBP, complex regional pain syndrome (CRPS and knee osteoarthritis (OA, relative to healthy controls. We find that different chronic pain types exhibit unique anatomical 'brain signatures'. Only the CBP group showed altered whole-brain gray matter volume, while regional gray matter density was distinct for each group. Voxel-wise comparison of gray matter density showed that the impact on the extent of chronicity of pain was localized to a common set of regions across all conditions. When gray matter density was examined for large regions approximating Brodmann areas, it exhibited unique large-scale distributed networks for each group. We derived a barcode, summarized by a single index of within-subject co-variation of gray matter density, which enabled classification of individual brains to their conditions with high accuracy. This index also enabled calculating time constants and asymptotic amplitudes for an exponential increase in brain re-organization with pain chronicity, and showed that brain reorganization with pain chronicity was 6 times slower and twice as large in CBP in comparison to CRPS. The results show an exuberance of brain anatomical reorganization peculiar to each condition and as such reflecting the unique maladaptive physiology of different types of chronic pain.

  19. Control of acute, chronic, and constitutive hyperammonemia by wild-type and genetically engineered Lactobacillus plantarum in rodents.

    Science.gov (United States)

    Nicaise, Charles; Prozzi, Deborah; Viaene, Eric; Moreno, Christophe; Gustot, Thierry; Quertinmont, Eric; Demetter, Pieter; Suain, Valérie; Goffin, Philippe; Devière, Jacques; Hols, Pascal

    2008-10-01

    Hyperammonemia is a common complication of acute and chronic liver diseases. Often accompanied with side effects, therapeutic interventions such as antibiotics or lactulose are generally targeted to decrease the intestinal production and absorption of ammonia. In this study, we aimed to modulate hyperammonemia in three rodent models by administration of wild-type Lactobacillus plantarum, a genetically engineered ammonia hyperconsuming strain, and a strain deficient for the ammonia transporter. Wild-type and metabolically engineered L. plantarum strains were administered in ornithine transcarbamoylase-deficient Sparse-fur mice, a model of constitutive hyperammonemia, in a carbon tetrachloride rat model of chronic liver insufficiency and in a thioacetamide-induced acute liver failure mice model. Constitutive hyperammonemia in Sparse-fur mice and hyperammonemia in a rat model of chronic hepatic insufficiency were efficiently decreased by Lactobacillus administration. In a murine thioacetamide-induced model of acute liver failure, administration of probiotics significantly increased survival and decreased blood and fecal ammonia. The ammonia hyperconsuming strain exhibited a beneficial effect at a lower dose than its wild-type counterpart. Improved survival in the acute liver failure mice model was associated with lower blood ammonia levels but also with a decrease of astrocyte swelling in the brain cortex. Modulation of ammonia was abolished after administration of the strain deficient in the ammonium transporter. Intestinal pH was clearly lowered for all strains and no changes in gut flora were observed. Hyperammonemia in constitutive model or after acute or chronic induced liver failure can be controlled by the administration of L. plantarum with a significant effect on survival. The mechanism involved in this ammonia decrease implicates direct ammonia consumption in the gut.

  20. Chronic Pain: How Challenging Are DDIs in the Analgesic Treatment of Inpatients with Multiple Chronic Conditions?

    Science.gov (United States)

    Siebenhuener, Klarissa; Eschmann, Emmanuel; Kienast, Alexander; Schneider, Dominik; Minder, Christoph E.; Saller, Reinhard; Zimmerli, Lukas; Blaser, Jürg; Battegay, Edouard

    2017-01-01

    Background Chronic pain is common in multimorbid patients. However, little is known about the implications of chronic pain and analgesic treatment on multimorbid patients. This study aimed to assess chronic pain therapy with regard to the interaction potential in a sample of inpatients with multiple chronic conditions. Methods and Findings We conducted a retrospective study with all multimorbid inpatients aged ≥18 years admitted to the Department of Internal Medicine of University Hospital Zurich in 2011 (n = 1,039 patients). Data were extracted from the electronic health records and reviewed. We identified 433 hospitalizations of patients with chronic pain and analyzed their combinations of chronic conditions (multimorbidity). We then classified all analgesic prescriptions according to the World Health Organization (WHO) analgesic ladder. Furthermore, we used a Swiss drug-drug interactions knowledge base to identify potential interactions between opioids and other drug classes, in particular coanalgesics and other concomitant drugs. Chronic pain was present in 38% of patients with multimorbidity. On average, patients with chronic pain were aged 65.7 years and had a mean number of 6.6 diagnoses. Hypertension was the most common chronic condition. Chronic back pain was the most common painful condition. Almost 90% of patients were exposed to polypharmacotherapy. Of the chronic pain patients, 71.1% received opioids for moderate to severe pain, 43.4% received coanalgesics. We identified 3,186 potential drug-drug interactions, with 17% classified between analgesics (without coanalgesics). Conclusions Analgesic drugs-related DDIs, in particular opioids, in multimorbid patients are often complex and difficult to assess by using DDI knowledge bases alone. Drug-multimorbidity interactions are not sufficiently investigated and understood. Today, the scientific literature is scarce for chronic pain in combination with multiple coexisting medical conditions and medication