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Sample records for nonprecessing case depending

  1. Black-hole binaries with non-precessing spins

    CERN Document Server

    Hannam, Mark; Ohme, Frank; Mueller, Doreen; Bruegmann, Bernd

    2010-01-01

    We present gravitational waveforms for the last orbits and merger of black-hole-binary (BBH) systems along two branches of the BBH parameter space: equal-mass binaries with equal non-precessing spins, and nonspinning unequal-mass binaries. The waveforms are calculated from numerical solutions of Einstein's equations for black-hole binaries that complete between six and ten orbits before merger. Along the equal-mass spinning branch, the spin parameter of each BH is $\\chi_i = S_i/M_i^2 \\in [-0.85,0.85]$, and along the unequal-mass branch the mass ratio is $q =M_2/M_1 \\in [1,4]$. We discuss the construction of low-eccentricity puncture initial data for these cases, the properties of the final merged BH, and compare the last 8-10 GW cycles up to $M\\omega = 0.1$ with the phase and amplitude predicted by standard post-Newtonian (PN) approximants. As in previous studies, we find that the phase from the 3.5PN TaylorT4 approximant is most accurate for nonspinning binaries. For equal-mass spinning binaries the 3.5PN Ta...

  2. Addressing the spin question in gravitational-wave searches: Waveform templates for inspiralling compact binaries with nonprecessing spins

    CERN Document Server

    Ajith, P

    2011-01-01

    This paper presents a post-Newtonian (PN) template family of gravitational waveforms from inspiralling compact binaries with non-precessing spins, where the spin effects are described by a single "reduced-spin" parameter. This template family, which reparametrizes all the spin-dependent PN terms in terms of the leading-order (1.5PN) spin-orbit coupling term in an approximate way, has very high overlaps (fitting factor > 0.99) with non-precessing binaries with arbitrary mass ratios and spins. We also show that this template family is "effectual" towards a significant fraction of generic spinning binaries in the comparable-mass regime (m_2/m_1 < 10), providing an attractive and feasible way of searching for gravitational waves (GWs) from spinning low-mass binaries. We also show that the secular (non-oscillatory) spin-dependent effects in the phase evolution (which are taken into account by the non-precessing templates) are more important than the oscillatory effects of precession in the comparable-mass (m_1 ...

  3. Towards models of gravitational waveforms from generic binaries: A simple approximate mapping between precessing and non-precessing inspiral signals

    CERN Document Server

    Schmidt, Patricia; Husa, Sascha

    2012-01-01

    One of the greatest theoretical challenges in the build-up to the era of second-generation gravitational-wave detectors is the modeling of generic binary waveforms. We introduce an approximation that has the potential to significantly simplify this problem. We show that generic precessing-binary inspiral waveforms (covering a seven-dimensional parameter space) can be mapped to only a two-dimensional space of non-precessing binaries, characterized by the mass ratio and a single effective total spin. The mapping consists of a time-dependent rotation of the waveforms into the quadrupole-aligned frame, and is extremely accurate (matches $> 0.99$ with parameter biases in the total spin of $\\Delta \\chi \\leq 0.04$), even in the case of transitional precession. In addition, we demonstrate a simple method to construct hybrid post-Newtonian--numerical-relativity precessing-binary waveforms in the quadrupole-aligned frame, and provide evidence that our approximate mapping can be used all the way to the merger. Finally, ...

  4. A prototype effective-one-body model for non-precessing spinning inspiral-merger-ringdown waveforms

    CERN Document Server

    Taracchini, Andrea; Buonanno, Alessandra; Barausse, Enrico; Boyle, Michael; Chu, Tony; Lovelace, Geoffrey; Pfeiffer, Harald P; Scheel, Mark A

    2012-01-01

    We first use five non-spinning and two mildly spinning (chi_i \\simeq -0.44, +0.44) numerical-relativity waveforms of black-hole binaries and calibrate an effective-one-body (EOB) model for non-precessing spinning binaries, notably its dynamics and the dominant (2,2) gravitational-wave mode. Then, we combine the above results with recent outcomes of small-mass-ratio simulations produced by the Teukolsky equation and build a prototype EOB model for detection purposes, which is capable of generating inspiral-merger-ringdown waveforms for non-precessing spinning black-hole binaries with any mass ratio and individual black-hole spins -1 \\leq chi_i \\lesssim 0.7. We compare the prototype EOB model to two equal-mass highly spinning numerical-relativity waveforms of black holes with spins chi_i = -0.95, +0.97, which were not available at the time the EOB model was calibrated. In the case of Advanced LIGO we find that the mismatch between prototype-EOB and numerical-relativity waveforms is always smaller than 0.003 for...

  5. Comparing gravitational waves from nonprecessing and precessing black hole binaries in the corotating frame

    CERN Document Server

    Pekowsky, Larne; Healy, Jim; Shoemaker, Deirdre

    2013-01-01

    Previous analytic and numerical calculations suggest that, at each instant, the emission from a precessing black hole binary closely resembles the emission from a nonprecessing analog. In this paper we quantitatively explore the validity and limitations of that correspondence, extracting the radiation from a large collection of roughly two hundred generic black hole binary merger simulations both in the simulation frame and in a corotating frame that tracks precession. To a first approximation, the corotating-frame waveforms resemble nonprecessing analogs, based on similarity over a band-limited frequency interval defined using a fiducial detector (here, advanced LIGO) and the source's total mass $M$. By restricting attention to masses $M\\in 200, 2500 M_\\odot$, we insure our comparisons are sensitive only to our simulated late-time inspiral, merger, and ringdown signals. In this mass region, every one of our precessing simulations can be fit by some physically similar member of the \\texttt{IMRPhenomB} phenome...

  6. A case of etizolam dependence

    Directory of Open Access Journals (Sweden)

    Sumit Gupta

    2014-01-01

    Full Text Available Etizolam is a thienodiazepine anxiolytic which is said to have lower dependence potential than other benzodiazepines. We report a case of etizolam dependence in a young male with social anxiety disorder and moderate depression. This case report highlights the fact that the same caution be exercised while prescribing etizolam with respect to its potential to cause dependence as with any other benzodiazepine.

  7. Inspiralling, Non-Precessing, Spinning Black Hole Binary Spacetime via Asymptotic Matching

    CERN Document Server

    Ireland, Brennan; Nakano, Hiroyuki; Campanelli, Manuela

    2015-01-01

    We construct a new global, fully analytic, approximate spacetime which accurately describes the dynamics of non-precessing, spinning black hole binaries during the inspiral phase of the relativistic merger process. This approximate solution of the vacuum Einstein's equations can be obtained by asymptotically matching perturbed Kerr solutions near the two black holes to a post-Newtonian metric valid far from the two black holes. This metric is then matched to a post-Minkowskian metric even farther out in the wave zone. The procedure of asymptotic matching is generalized to be valid on all spatial hypersurfaces, instead of a small group of initial hypersurfaces discussed in previous works. This metric is well suited for long term dynamical simulations of spinning black hole binary spacetimes prior to merger, such as studies of circumbinary gas accretion which requires hundreds of binary orbits.

  8. "Complete" gravitational waveforms for black-hole binaries with non-precessing spins

    CERN Document Server

    Ajith, P; Husa, S; Chen, Y; Brügmann, B; Dorband, N; Müller, D; Ohme, F; Pollney, D; Reisswig, C; Santamaria, L; Seiler, J

    2009-01-01

    We present the first analytical inspiral-merger-ringdown gravitational waveforms from black-hole (BH) binaries with non-precessing spins. By matching a post-Newtonian description of the inspiral to a set of numerical calculations performed in full general relativity, we obtain a waveform family with a conveniently small number of physical parameters. The physical content of these waveforms includes the "orbital hang-up" effect, when BHs are spinning rapidly along the direction of the orbital angular momentum. These waveforms will allow us to detect a larger parameter space of BH binary coalescence, to explore various scientific questions related to GW astronomy, and could dramatically improve the expected detection rates of GW detectors.

  9. Asymptotically Matched Spacetime Metric for Non-Precessing, Spinning Black Hole Binaries

    CERN Document Server

    Gallouin, Louis; Yunes, Nicolas; Campanelli, Manuela

    2012-01-01

    We construct a closed-form, fully analytical 4-metric that approximately represents the spacetime evolution of non-precessing, spinning black hole binaries from infinite separations up to a few orbits prior to merger. We employ the technique of asymptotic matching to join a perturbed Kerr metric in the neighborhood of each spinning black hole to a near-zone, post-Newtonian metric farther out. The latter is already naturally matched to a far-zone, post-Minkowskian metric that accounts for full temporal retardation. The result is a 4-metric that is approximately valid everywhere in space and in a small bundle of spatial hypersurfaces. We here restrict our attention to quasi- circular orbits, but the method is valid for any orbital motion or physical scenario, provided an overlapping region of validity or buffer zone exists. A simple extension of such a metric will allow for future studies of the accretion disk and jet dynamics around spinning back hole binaries.

  10. Ready-to-use post-Newtonian gravitational waveforms for binary black holes with non-precessing spins: An update

    CERN Document Server

    Mishra, Chandra Kant; Arun, K G; Faye, Guillaume

    2016-01-01

    For black-hole binaries whose spins are (anti-) aligned with respect to the orbital angular momentum of the binary, we compute the frequency domain phasing coefficients including the quadratic-in-spin terms up to the third post-Newtonian (3PN) order, the cubic-in-spin terms at the leading order, 3.5PN, and the spin-orbit effects up to the 4PN order. In addition, we obtain the 2PN spin contributions to the amplitude of the frequency-domain gravitational waveforms for non-precessing binaries, using recently derived expressions for the time-domain polarization amplitudes of binaries with generic spins, complete at that accuracy level. These two results are updates to Arun et al. (2009) [1] for amplitude and Wade et al. (2013) [2] for phasing. They should be useful to construct banks of templates that model accurately non-precessing inspiraling binaries, for parameter estimation studies, and or constructing analytical template families that accounts for the inspiral-merger-ringdown phases of the binary.

  11. Frequency-domain gravitational waves from nonprecessing black-hole binaries. II. A phenomenological model for the advanced detector era

    Science.gov (United States)

    Khan, Sebastian; Husa, Sascha; Hannam, Mark; Ohme, Frank; Pürrer, Michael; Forteza, Xisco Jiménez; Bohé, Alejandro

    2016-02-01

    We present a new frequency-domain phenomenological model of the gravitational-wave signal from the inspiral, merger and ringdown of nonprecessing (aligned-spin) black-hole binaries. The model is calibrated to 19 hybrid effective-one-body-numerical-relativity waveforms up to mass ratios of 1 ∶18 and black-hole spins of |a /m |˜0.85 (0.98 for equal-mass systems). The inspiral part of the model consists of an extension of frequency-domain post-Newtonian expressions, using higher-order terms fit to the hybrids. The merger ringdown is based on a phenomenological ansatz that has been significantly improved over previous models. The model exhibits mismatches of typically less than 1% against all 19 calibration hybrids and an additional 29 verification hybrids, which provide strong evidence that, over the calibration region, the model is sufficiently accurate for all relevant gravitational-wave astronomy applications with the Advanced LIGO and Virgo detectors. Beyond the calibration region the model produces physically reasonable results, although we recommend caution in assuming that any merger-ringdown waveform model is accurate outside its calibration region. As an example, we note that an alternative nonprecessing model, SEOBNRv2 (calibrated up to spins of only 0.5 for unequal-mass systems), exhibits mismatch errors of up to 10% for high spins outside its calibration region. We conclude that waveform models would benefit most from a larger number of numerical-relativity simulations of high-aligned-spin unequal-mass binaries.

  12. Matching post-Newtonian and numerical relativity waveforms: systematic errors and a new phenomenological model for non-precessing black hole binaries

    CERN Document Server

    Santamaria, L; Ajith, P; Bruegmann, B; Dorband, N; Hannam, M; Husa, S; Moesta, P; Pollney, D; Reisswig, C; Seiler, J; Krishnan, B

    2010-01-01

    We present a new phenomenological gravitational waveform model for he inspiral and coalescence of non-precessing spinning black hole binaries. Our approach is based on a frequency domain matching of post-Newtonian inspiral waveforms with numerical relativity based binary black hole coalescence waveforms. We quantify the various possible sources of systematic errors that arise in matching post-Newtonian and numerical relativity waveforms, and we use a matching criteria based on minimizing these errors; we find that the dominant source of errors are those in the post-Newtonian waveforms near the merger. An analytical formula for the dominant mode of the gravitational radiation of non-precessing black hole binaries is presented that captures the phenomenology of the hybrid waveforms. Its implementation in the current searches for gravitational waves should allow cross-checks of other inspiral-merger-ringdown waveform families and improve the reach of gravitational wave searches.

  13. Biperiden Dependence: Case Report and Literature Review

    Directory of Open Access Journals (Sweden)

    Fernando Espi Martinez

    2012-01-01

    Full Text Available Anticholinergic drugs are frequently used in psychiatry for the prophylaxis and treatment of extrapiramidal symptoms caused by neuroleptics. Abuse of anticholinergic agents has been reported in patients with psychotic disorders, on treatment with neuroleptics, and polysubstance use disorders. We are reporting the case of a patient who presented with hypoactive delirium as a consequence of biperiden dependence. The clinician must pay special attention to detect anticholinergic misuse in patients presenting with delirium of unknown cause.

  14. A Case of Insulin-dependent Diabetes.

    Science.gov (United States)

    Gonzalez, Nicholas

    2016-07-01

    Background • There is a paucity of information on alternative, nutrition-based treatments for insulin-dependent diabetes. Primary Study Objective • This case report provides detailed information on the nutrition-based treatment of a man with insulin-dependent diabetes. Methods/Design • This is a single case report taken from the author's private practice. Setting • The treatment was provided at a private office in New York, NY, USA. Participants • A single patient in the author's practice is reported. Intervention • The patient was treated with a combination of pancreatic enzymes, supplements and nutrients, and cleansing and detoxification procedures, plus amber lenses for severe insomnia. Primary Outcome Measures • The outcome measures were patient self-report of symptoms, overall well-being, and function at work and in leisure time; observation of the patient by the physician; and blood work. Results • The patient described dramatic, sustained improvement in terms of symptoms, function, well-being, and life satisfaction. Improvement in blood sugar control was documented by blood work. Conclusion • The complex, tailored nutritional protocol combined with detoxification procedures, resulted in marked improvement in a patient who had been treated by numerous different physicians without benefit prior to his consulting with the author.

  15. Hierarchical data-driven approach to fitting numerical relativity data for non-precessing binary black holes, with an application to final spin and radiated energy

    CERN Document Server

    Jiménez-Forteza, Xisco; Husa, Sascha; Hannam, Mark; Khan, Sebastian; Pürrer, Michael

    2016-01-01

    Numerical relativity is an essential tool in studying the coalescence of binary black holes (BBHs). It is still computationally prohibitive to cover the BBH parameter space exhaustively, making phenomenological fitting formulas for BBH waveforms and final-state properties important for practical applications. We describe a general hierarchical bottom-up fitting methodology to design and calibrate fits to numerical relativity simulations for the three-dimensional parameter space of quasi-circular non-precessing merging BBHs, spanned by mass ratio and by the individual spin components orthogonal to the orbital plane. Particular attention is paid to incorporating the extreme-mass-ratio limit and to the subdominant unequal-spin effects. As an illustration of the method, we provide two applications, to the final spin and final mass (or equivalently: radiated energy) of the remnant black hole. We obtain results broadly consistent with previously published fits, but with improvements in the approach to extremal limi...

  16. An improved effective-one-body model of spinning, nonprecessing binary black holes for the era of gravitational-wave astrophysics with advanced detectors

    CERN Document Server

    Bohé, Alejandro; Taracchini, Andrea; Buonanno, Alessandra; Babak, Stanislav; Harry, Ian W; Hinder, Ian; Ossokine, Serguei; Pürrer, Michael; Raymond, Vivien; Chu, Tony; Fong, Heather; Kumar, Prayush; Pfeiffer, Harald P; Boyle, Michael; Hemberger, Daniel A; Kidder, Lawrence E; Lovelace, Geoffrey; Scheel, Mark A; Szilágyi, Béla

    2016-01-01

    We improve the accuracy of the effective-one-body (EOB) waveforms that were employed during the first observing run of Advanced LIGO for binaries of spinning, nonprecessing black holes by calibrating them to a set of 141 numerical-relativity (NR) waveforms. The NR simulations expand the domain of calibration towards larger mass ratios and spins, as compared to the previous EOBNR model. Merger-ringdown waveforms computed in black-hole perturbation theory for Kerr spins close to extremal provide additional inputs to the calibration. For the inspiral-plunge phase, we use a Markov-chain Monte Carlo algorithm to efficiently explore the calibration space. For the merger-ringdown phase, we fit the NR signals with phenomenological formulae. After extrapolation of the calibrated model to arbitrary mass ratios and spins, the (dominant-mode) EOBNR waveforms have faithfulness --- at design Advanced-LIGO sensitivity --- above $99\\%$ against all the NR waveforms, including 16 additional waveforms used for validation, when ...

  17. Implementing a search for gravitational waves from non-precessing, spinning binary black holes

    CERN Document Server

    Capano, Collin; Privitera, Stephen; Buonanno, Alessandra

    2016-01-01

    Searching for gravitational waves (GWs) from binary black holes (BBHs) with LIGO and Virgo involves matched-filtering data against a set of representative signal waveforms --- a template bank --- chosen to cover the full signal space of interest with as few template waveforms as possible. Although the component black holes may have significant angular momenta (spin), previous searches for BBHs have filtered LIGO and Virgo data using only waveforms where both component spins are zero. This leads to a loss of signal-to-noise ratio for signals where this is not the case. Combining the best available template placement techniques and waveform models, we construct a template bank of GW signals from BBHs with component spins $\\chi_{1,2}\\in [-0.99, 0.99]$ aligned with the orbital angular momentum, component masses $m_{1,2}\\in [2, 48]\\,\\mathrm{M}_\\odot$, and total mass $M_\\mathrm{total} \\leq 50\\,\\mathrm{M}_\\odot$. Using effective-one-body waveforms with spin effects, we show that less than $3\\%$ of the maximum signal...

  18. Implementing a search for gravitational waves from binary black holes with nonprecessing spin

    Science.gov (United States)

    Capano, Collin; Harry, Ian; Privitera, Stephen; Buonanno, Alessandra

    2016-06-01

    Searching for gravitational waves (GWs) from binary black holes (BBHs) with LIGO and Virgo involves matched-filtering data against a set of representative signal waveforms—a template bank—chosen to cover the full signal space of interest with as few template waveforms as possible. Although the component black holes may have significant angular momenta (spin), previous searches for BBHs have filtered LIGO and Virgo data using only waveforms where both component spins are zero. This leads to a loss of signal-to-noise ratio for signals where this is not the case. Combining the best available template placement techniques and waveform models, we construct a template bank of GW signals from BBHs with component spins χ1 ,2∈[-0.99 ,0.99 ] aligned with the orbital angular momentum, component masses m1 ,2∈[2 ,48 ]M⊙ , and total mass Mtotal≤50 M⊙ . Using effective-one-body waveforms with spin effects, we show that less than 3% of the maximum signal-to-noise ratio (SNR) of these signals is lost due to the discreetness of the bank, using the early Advanced LIGO noise curve. We use simulated Advanced LIGO noise to compare the sensitivity of this bank to a nonspinning bank covering the same parameter space. In doing so, we consider the competing effects between improved SNR and signal-based vetoes and the increase in the rate of false alarms of the aligned-spin bank due to covering a larger parameter space. We find that the aligned-spin bank can be a factor of 1.3-5 more sensitive than a nonspinning bank to BBHs with dimensionless spins >+0.6 and component masses ≳20 M⊙ . Even larger gains are obtained for systems with equally high spins but smaller component masses.

  19. [Schizophrenia and amphetamine dependence. A case report].

    Science.gov (United States)

    Dervaux, A; Krebs, M-O; Laqueille, X

    2005-01-01

    Whereas observations of psychotic disorders induced by amphetamines are common, few observations described the impact of chronic amphetamine abuse on schizophrenic patients. We report the case of a schizophrenic patient who presented with amphetamine dependence for several years, without other accompanying addiction. During his adolescence, Mr. X. gradually developed delusional beliefs of persecution and telepathy. He believed that the other pupils and teachers spoke about him in malicious terms. At the age of 23, Mr. X began to consume 60-100 mg/week of amphetamines orally. He consumed amphetamines during 7 years. The delusions, in particular the auditory hallucinations worsened after the use of amphetamines. Subsequently, he married and was declared unfit for national service due to the psychotic disorders. Mr. X received neuroleptic treatment with moderate effects on the psychotic symptoms. Between the age of 24 and 30, the patient presented persecutory, megalomanic and physical transformation beliefs, delusions of being controlled as well as auditory, somatic-tactile and visual hallucinations. At the age of 30, while he had stopped his consumption of amphetamines for 9 months, the patient, overwhelmed with the delusions, murdered his wife. He was sent in jail for 13 months, and subsequently hospitalized for one year in a high security psychiatric department and 7 years in our psychiatric department. The neuroleptic treatment was effective, particularly against the hallucinations. Following stabilisation, the symptomatology of the patient was marked by a disorganization syndrome, including prominent thought disorder, disorganized speech, associative loosening, frequent derailments and negative signs of schizophrenia, in particular affective flattening and blunting of emotional expression. When the patient was 43, a trial discharge was authorized owing to improvement of his condition. The neuroleptic treatment was switched with single-drug olanzapine therapy, 10

  20. Delusional parasitosis with alcohol dependence: A case report

    Directory of Open Access Journals (Sweden)

    Nahid Dave, Austin Fernandes, Anup Bharati, Avinash De Sousa

    2014-04-01

    Full Text Available Delusional parasitosis is a syndrome with which most psychiatrists are familiar. However, most reports consist of case reports or small series. We present here a case report of delusional parasitosis of an extremely bizarre nature in a case of alcohol dependence that responded to pimozide, haloperidol and electroconvulsive therapy (ECT.

  1. Frequency-domain gravitational waves from non-precessing black-hole binaries. I. New numerical waveforms and anatomy of the signal

    CERN Document Server

    Husa, Sascha; Hannam, Mark; Pürrer, Michael; Ohme, Frank; Forteza, Xisco Jiménez; Bohé, Alejandro

    2015-01-01

    In this paper we discuss the anatomy of frequency-domain gravitational-wave signals from non-precessing black-hole coalescences with the goal of constructing accurate phenomenological waveform models. We first present new numerical-relativity simulations for mass ratios up to 18 including spins. From a comparison of different post-Newtonian approximants with numerical-relativity data we select the uncalibrated SEOBNRv2 model as the most appropriate for the purpose of constructing hybrid post-Newtonian/numerical-relativity waveforms, and we discuss how we prepare time-domain and frequency-domain hybrid data sets. We then use our data together with results in the literature to calibrate simple explicit expressions for the final spin and radiated energy. Equipped with our prediction for the final state we then develop a simple and accurate merger-ringdown-model based on modified Lorentzians in the gravitational wave amplitude and phase, and we discuss a simple method to represent the low frequency signal augment...

  2. Hierarchical data-driven approach to fitting numerical relativity data for nonprecessing binary black holes with an application to final spin and radiated energy

    Science.gov (United States)

    Jiménez-Forteza, Xisco; Keitel, David; Husa, Sascha; Hannam, Mark; Khan, Sebastian; Pürrer, Michael

    2017-03-01

    Numerical relativity is an essential tool in studying the coalescence of binary black holes (BBHs). It is still computationally prohibitive to cover the BBH parameter space exhaustively, making phenomenological fitting formulas for BBH waveforms and final-state properties important for practical applications. We describe a general hierarchical bottom-up fitting methodology to design and calibrate fits to numerical relativity simulations for the three-dimensional parameter space of quasicircular nonprecessing merging BBHs, spanned by mass ratio and by the individual spin components orthogonal to the orbital plane. Particular attention is paid to incorporating the extreme-mass-ratio limit and to the subdominant unequal-spin effects. As an illustration of the method, we provide two applications, to the final spin and final mass (or equivalently: radiated energy) of the remnant black hole. Fitting to 427 numerical relativity simulations, we obtain results broadly consistent with previously published fits, but improving in overall accuracy and particularly in the approach to extremal limits and for unequal-spin configurations. We also discuss the importance of data quality studies when combining simulations from diverse sources, how detailed error budgets will be necessary for further improvements of these already highly accurate fits, and how this first detailed study of unequal-spin effects helps in choosing the most informative parameters for future numerical relativity runs.

  3. Frequency-domain gravitational waves from non-precessing black-hole binaries. II. A phenomenological model for the advanced detector era

    CERN Document Server

    Khan, Sebastian; Hannam, Mark; Ohme, Frank; Pürrer, Michael; Forteza, Xisco Jiménez; Bohé, Alejandro

    2015-01-01

    We present a new frequency-domain phenomenological model of the gravitational-wave signal from the inspiral, merger and ringdown of non-precessing (aligned-spin) black-hole binaries. The model is calibrated to 19 hybrid effective-one-body--numerical-relativity waveforms up to mass ratios of 1:18 and black-hole spins of $|a/m| \\sim 0.85$ ($0.98$ for equal-mass systems). The inspiral part of the model consists of an extension of frequency-domain post-Newtonian expressions, using higher-order terms fit to the hybrids. The merger-ringdown is based on a phenomenological ansatz that has been significantly improved over previous models. The model exhibits mismatches of typically less than 1\\% against all 19 calibration hybrids, and an additional 29 verification hybrids, which provide strong evidence that, over the calibration region, the model is sufficiently accurate for all relevant gravitational-wave astronomy applications with the Advanced LIGO and Virgo detectors. Beyond the calibration region the model produce...

  4. Cow Dung Ingestion and Inhalation Dependence: A Case Report

    Science.gov (United States)

    Khairkar, Praveen; Tiple, Prashant; Bang, Govind

    2009-01-01

    Although abuse of several unusual inhalants had been documented, addiction to cow dung fumes or their ashes has not been reported in medical literature as yet. We are reporting a case of cow dung dependence in ingestion and inhalational form.

  5. Cow Dung Ingestion and Inhalation Dependence: A Case Report

    Science.gov (United States)

    Khairkar, Praveen; Tiple, Prashant; Bang, Govind

    2009-01-01

    Although abuse of several unusual inhalants had been documented, addiction to cow dung fumes or their ashes has not been reported in medical literature as yet. We are reporting a case of cow dung dependence in ingestion and inhalational form.

  6. Zolpidem dependence, abuse and withdrawal: A case report

    Directory of Open Access Journals (Sweden)

    Mostafa Heydari

    2013-01-01

    Full Text Available Zolpidem, a nonbenzodiazepine hypnotic, binds to the benzodiazepine binding site on the gamma-aminobutyric acid type A (GABA-A receptors. Many studies have reported efficacy and safety of zolpidem in treatment of insomnia, low abuse, and dependence capability. However, many cases of zolpidem abuse and dependence were reported around the world. This case showed that zolpidem can exert abuse capability, euphoric mood, tolerance, and withdrawal syndrome.

  7. Improved effective-one-body model of spinning, nonprecessing binary black holes for the era of gravitational-wave astrophysics with advanced detectors

    Science.gov (United States)

    Bohé, Alejandro; Shao, Lijing; Taracchini, Andrea; Buonanno, Alessandra; Babak, Stanislav; Harry, Ian W.; Hinder, Ian; Ossokine, Serguei; Pürrer, Michael; Raymond, Vivien; Chu, Tony; Fong, Heather; Kumar, Prayush; Pfeiffer, Harald P.; Boyle, Michael; Hemberger, Daniel A.; Kidder, Lawrence E.; Lovelace, Geoffrey; Scheel, Mark A.; Szilágyi, Béla

    2017-02-01

    We improve the accuracy of the effective-one-body (EOB) waveforms that were employed during the first observing run of Advanced LIGO for binaries of spinning, nonprecessing black holes by calibrating them to a set of 141 numerical-relativity (NR) waveforms. The NR simulations expand the domain of calibration toward larger mass ratios and spins, as compared to the previous EOBNR model. Merger-ringdown waveforms computed in black-hole perturbation theory for Kerr spins close to extremal provide additional inputs to the calibration. For the inspiral-plunge phase, we use a Markov-chain Monte Carlo algorithm to efficiently explore the calibration space. For the merger-ringdown phase, we fit the NR signals with phenomenological formulae. After extrapolation of the calibrated model to arbitrary mass ratios and spins, the (dominant-mode) EOBNR waveforms have faithfulness—at design Advanced-LIGO sensitivity—above 99% against all the NR waveforms, including 16 additional waveforms used for validation, when maximizing only on initial phase and time. This implies a negligible loss in event rate due to modeling for these binary configurations. We find that future NR simulations at mass ratios ≳4 and double spin ≳0.8 will be crucial to resolving discrepancies between different ways of extrapolating waveform models. We also find that some of the NR simulations that already exist in such region of parameter space are too short to constrain the low-frequency portion of the models. Finally, we build a reduced-order version of the EOBNR model to speed up waveform generation by orders of magnitude, thus enabling intensive data-analysis applications during the upcoming observation runs of Advanced LIGO.

  8. 38 CFR 21.328 - Two veteran cases-dependents.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Two veteran cases-dependents. 21.328 Section 21.328 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS.... Chapter 31 Authorization of Subsistence Allowance and Training and Rehabilitation Services § 21.328 Two...

  9. EDTA-dependent pseudothrombocytopenia in a case of liver cirrhosis.

    Science.gov (United States)

    Matarazzo, M; Conturso, V; Di Martino, M; Chiurazzi, F; Guida, G; Morante, R

    2000-06-01

    Pseudothrombocytopenia (PTCP) is the consequence of an EDTA-activated platelet agglutination, resulting in a spuriously low platelet count. We report the case of a 54-year-old man with EDTA-dependent PTCP associated with liver cirrhosis. He couldn't undergo endoscopic examination and dental care for two years because of a previous diagnosis of severe thrombocytopenia secondary to liver cirrhosis. Lack of PTCP recognition may lead the physician to misdiagnosis and mismanagement of the patient.

  10. A successful case of dose reduction in etizolam dependence using fine granules: a case report

    Directory of Open Access Journals (Sweden)

    Nishii S

    2014-08-01

    Full Text Available Shigeki Nishii,1 Hikaru Hori,1 Toshifumi Kishimoto,2 Jun Nakamura1 1Department of Psychiatry, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan; 2Department of Psychiatry, Nara Medical University, Shijocho, Kashihara, Nara, Japan Abstract: The prevalence of benzodiazepine consumption in Japan is one of the highest worldwide. Etizolam is the most abused drug of the benzodiazepine class. The treatment of benzodiazepine dependence is difficult. We report a case of successful dosage reduction in a 24-year-old female patient with etizolam dependence. She was diagnosed with etizolam dependence at the age of 22 years old. We proposed a benzodiazepine dependence treatment that involved replacing etizolam with a long-acting benzodiazepine class drug in conjunction with a long-term weaning plan. However, the patient refused the treatment and insisted that reducing the number of tablets would increase her anxiety. After providing a detailed explanation and receiving consent from the patient, a treatment regimen consisting of fine granules of etizolam mixed with lactose granules was begun with the aim of reducing the percentage of etizolam at a rate of 0.3 mg/week. The treatment of etizolam dependence in this patient was successful. This treatment strategy may be an effective option for patients who are difficult to treat with conventional methods, or who have anxiety regarding the reduction of the amount of the drug itself. Keywords: benzodiazepine, Japan, dependence, etizolam

  11. [Recurrent acute pericarditis and corticoid dependence. Apropos of 10 cases].

    Science.gov (United States)

    Godeau, P; Derrida, J P; Bletry, O; Herreman, G

    1975-10-09

    The authors report ten cases of acute recurrent pericarditis observed over a period of 5 years and emphasize the frequency of these relapses involving 15 to 20% of cases of acute pericarditis. Usually, no cause is found and, althrough an immunological mechanism has been suggested, there is no common test which may confirm or disprove this theory. The risk of ultimate constrictive pericarditis is minimal and this risk is thus not taken into consideration in deciding on treatment. On the other hand, the undesirable effects of corticosteroids which favour relapses, seem to be demonstrated. The use of corticosteroids in cases of acute pericarditis should thus be exceptional and one should prefer non-steroid anti-inflammatory drugs. Immunosuppressors and pericardectomy should be reserved for the rare forms where the disease progresses and relapses continue after cortisone has been stopped.

  12. Model Transformation for a System of Systems Dependability Safety Case

    Science.gov (United States)

    Murphy, Judy; Driskell, Steve

    2011-01-01

    The presentation reviews the dependability and safety effort of NASA's Independent Verification and Validation Facility. Topics include: safety engineering process, applications to non-space environment, Phase I overview, process creation, sample SRM artifact, Phase I end result, Phase II model transformation, fault management, and applying Phase II to individual projects.

  13. CASE STUDY ON RE-ADJUSTMENTS DEPENDING ON PRICE MODIFICATION

    Directory of Open Access Journals (Sweden)

    Cozma Ighian Diana

    2011-01-01

    Full Text Available Inflationary moments, characterized by significant price rises, have proved that accountingsystems based on historical costs provide a distorted image of the reality: the elements ofthe balance sheet are under-valuated, and the stock-related expenses and amortization in theprofit and loss account are also under-valuated. Under these circumstances, the result isover-valuated, and its distribution leads to allotments from the company’s capital. In thispaper we draw up a case study with regards to the methods used for adjusting pricemodification, clearly outlining, through a comparative analysis, the main differencesbetween the accounting system based on historical cost and inflation accounting.

  14. Rifted Continental Margins: The Case for Depth-Dependent Extension

    Science.gov (United States)

    Huismans, Ritske S.; Beaumont, Christopher

    2016-04-01

    Even though many basic properties of non-volcanic rifted margins are predicted by uniform extension of the lithosphere, uniform extension fails to explain other important characteristics. Particularly significant discrepancies are observed at: 1) the Iberia-Newfoundland conjugate margins (Type I), where large tracts of continental mantle lithosphere are exposed at the seafloor, and at; 2) ultra-wide central South Atlantic margins (Type II) where continental crust spans wide regions below which it appears that lower crust and mantle lithosphere were removed. Neither corresponds to uniform extension in which crust and mantle thin by the same factor. Instead, either the crust or mantle lithosphere has been preferentially removed during extension. We show that the Type I and II styles are respectively reproduced by dynamical numerical lithospheric stretching models (Models I-A/C and II-A/C) that undergo depth-dependent extension. In this notation A and C imply underplating of the rift zone during rifting by asthenosphere and lower cratonic lithosphere, respectively. We also present results for models with a weak upper crust and strong lower crust, Models III-A/C, to show that lower crust can also be removed from beneath the rift zone by horizontal advection with the mantle lithosphere. From the model results we infer that these Types I, II, and III margin styles are controlled by the strength of the mid/lower crust, which determines the amount of decoupling between upper and lower lithosphere during extension and the excision of crust or mantle. We also predict the styles of sedimentary basins that form on these margins as a test of the concepts presented

  15. Modafinil Dependence and Hypersexuality: A Case Report and Review of the Evidence

    OpenAIRE

    Swapnajeet, Sahoo; Subodh, BN.; Gourav, Gupta

    2016-01-01

    Apart from sleep wake disorders, nowadays, modafinil is being prescribed for several psychiatric disorders including depression. Despite being reported as to be having very low abuse potential, cases of modafinil dependence had come to the limelight. In this case report, we describe a 35 year old man with bipolar affective disorder while in remission who developed modafinil dependence and later on, had hypersexuality when he increased the dose of modafinil from 400 to 1,000 mg/day. Existing l...

  16. [A case of compulsive buying--impulse control disorder or dependence disorder?].

    Science.gov (United States)

    Croissant, Bernhard; Klein, Oliver; Löber, Sabine; Mann, Karl

    2009-05-01

    It is unclear what disease entity causes compulsive buying. In ICD-10 and DSM-IV, compulsive buying is classified as "Impulse control disorder--not otherwise classified". Some publications interpret compulsive buying rather as a dependence disorder. We present the case of a male patient with compulsive buying syndrome. We discuss the close relationship to dependence disorders. The patient showed symptoms which would normally be associated with a dependence disorder. On the basis of a wider understanding of the dependency concept, as it is currently being discussed, we believe that the patient has shown a typical buying behavior that has presumably activated a reward loop similar to that of a substance dependency.

  17. 20 CFR 10.414 - What reports of dependents are needed in death cases?

    Science.gov (United States)

    2010-04-01

    ... death cases? 10.414 Section 10.414 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS...' COMPENSATION ACT, AS AMENDED Compensation and Related Benefits Compensation for Death § 10.414 What reports of dependents are needed in death cases? If a beneficiary is receiving compensation benefits on account of an...

  18. EDTA-dependent pseudothrombocytopenia confirmed by supplementation of kanamycin; a case report.

    Science.gov (United States)

    Ahn, Hae Lyun; Jo, Young Il; Choi, Young Suk; Lee, Jung Yeon; Lee, Hae Woon; Kim, Seong Ryul; Sim, Joon; Lee, Weon; Jin, Chun Jo

    2002-03-01

    EDTA-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a spurious low platelet count due to EDTA-induced aggregation of platelets. Since the failure to recognize EDTA-dependent PTCP may result in incorrect diagnosis and inappropriate treatment, the recognition of this phenomenon is very important. We report an insidious case of EDTA-dependent PTCP confirmed by supplementation of kanamycin to anticoagulant in a 53-year-old women. Although sodium citrate and heparin usually prevented the aggregation of platelets in EDTA-dependent PTCP patients, these anticoagulants failed in preventing PTCP in our case. EDTA-dependent PTCP was confirmed by the findings that the clumping of platelets on microscopic evaluation was found in EDTA-anticoagulated blood samples, whereas thrombocytopenia and platelet aggregation were not revealed in the sample supplemented with kanamycin.

  19. Use of functioning-disability and dependency for case-mix and subtyping of schizophrenia

    Directory of Open Access Journals (Sweden)

    Susana Ochoa

    2012-03-01

    Full Text Available Background and Objectives: To evaluate the utility of the constructs functioning and disability (F & D and dependency for case-mix and subtyping of patients with schizophrenia by psychosocial, clinical, use of services and attention received from informal carers. Methods: A randomly selected total of 205 people with schizophrenia, and their careers were evaluated through PANSS, DAS-sv, Objective and Subjective Burden Scale (ECFOS-II and use of services. Results: Two groups and Four profiles were identified according to levels of Dependency: The non-dependent group was made of two profiles: independent (I, and persons with disability in the community (DiC. The dependent group included persons with dependency in the community (DeC and persons with dependency in hospital care (DeH. There are clinical and psychosocial differences between these profiles being the dependent the most severe. Regarding use of services, DeC use the most resources, with the exception DeH (more hospitalization resources. The DeC profile generate greater family burden in the following areas; taking medication, being accompanied to appointments, and management than the DiC, despite both groups showing a high need for support. Conclusions: Dependency is a relevant construct for case-mix and subtyping in schizophrenia, and it is related to severity both at the social and clinical level. DeC generate more family burden than the other profiles, followed by DiC (patients with schizophrenia with disability but non-dependent.

  20. Does human bocavirus infection depend on helper viruses? A challenging case report

    Directory of Open Access Journals (Sweden)

    Brockmann Michael

    2011-08-01

    Full Text Available Abstract A case of severe diarrhoea associated with synergistic human bocavirus type 1 (HBoV and human herpes virus type 6 (HHV6 is reported. The case supports the hypotheses that HBoV infection under clinical conditions may depend on helper viruses, or that HBoV replicates by a mechanism that is atypical for parvoviruses, or that HBoV infection can be specifically treated with cidofovir.

  1. Managing Resource Dependence Difficulties in African Higher Education: The Case of Multiple Exchange Relationships

    Science.gov (United States)

    Wangenge-Ouma, Gerald

    2011-01-01

    The paper has a twofold structure and focus. The first part is an examination of the funding challenges facing African universities resulting mainly from public finance difficulties, and the second part is a case study of how some Kenyan and South African public universities have attempted to mitigate resource dependence difficulties through…

  2. A case of extreme prematurity and delayed diagnosis of pyridoxine-dependent epilepsy.

    Science.gov (United States)

    Al-Saman, Abdulaziz S; Rizk, Tamer M

    2012-10-01

    Pyridoxine-dependent epilepsy presents early in life, even in utero. It is usually refractory to conventional antiepileptic medications and responds only to lifelong pyridoxine supplementation. Seizures are usually generalized tonic clonic. We report a 3-year-old child that was born prematurely at 25 weeks of gestation. He presented with abnormal movements in the second month of life. At 10 months of age he presented with status epilepticus, which was refractory to multiple antiepileptic medications and was controlled with intravenous pyridoxine. An elevated level of a-aminoadipic semialdehyde excretion in the urine supported the diagnosis of pyridoxine-dependent epilepsy. Subsequently, a c.1195G>C homozygous mutation in the 5q31 aldehyde dehydrogenase 7A1 gene was confirmed. This case calls for considering pyridoxine-dependent epilepsy and its early management in cases with resistant seizures; even in the presence of extreme prematurity with its neurological consequences.

  3. Modafinil Dependence and Hypersexuality: A Case Report and Review of the Evidence

    Science.gov (United States)

    Swapnajeet, Sahoo; Subodh, BN; Gourav, Gupta

    2016-01-01

    Apart from sleep wake disorders, nowadays, modafinil is being prescribed for several psychiatric disorders including depression. Despite being reported as to be having very low abuse potential, cases of modafinil dependence had come to the limelight. In this case report, we describe a 35 year old man with bipolar affective disorder while in remission who developed modafinil dependence and later on, had hypersexuality when he increased the dose of modafinil from 400 to 1,000 mg/day. Existing literature suggests that modafinil when taken above prescribed doses can cause many side effects ranging from nausea, vomiting to psychotic exacerbation and mania. However, hypersexuality as a side effect of modafinil overuse is not commonly seen. The exact pathophysiological mechanism of modafinil induced hypersexuality is not clear. Clinicians should be aware of possibility of modafinil leading to dependence and this rare significant side effect of modafinil. PMID:27776397

  4. Effect of Pressure dependent demand on pipe network analysis: A case study

    Directory of Open Access Journals (Sweden)

    MINAKSHI SHRIVASTAVA

    2014-01-01

    Full Text Available Water distribution network is most important part of world’s infrastructure. In the present work, analysis for proposed site of school of planning and architecture, Bhopal is done by using demand based analysis and the design is further analyzed for pressure dependent demand. Detailed study of variation of threshold pressure with power function is carried out .Complete site is divided into two zones having two separate water tank for supply and the analysis is done by varying threshold pressure and power function in case of pressure dependent demand by using commercial pipe network analysis software.

  5. A Case of Stercoral Perforation Detected on CT Requiring Proctocolectomy in a Heroin-Dependent Patient

    Directory of Open Access Journals (Sweden)

    William H. Seligman

    2016-01-01

    Full Text Available Stercoral perforation of the colon is rare but carries with it significant morbidity and mortality. Stercoral perforation usually occurs in elderly, immobile patients with chronic constipation. In this manuscript, we report the case of stercoral perforation in a patient due to chronic heroin dependence. We report the case of a 56-year-old male patient with stercoral perforation, diagnosed by computed tomography, secondary to heroin dependence, requiring proctocolectomy and an end ileostomy. There are very few reports in the literature describing cases of stercoral perforation and questions have been asked about the importance of preoperative cross-sectional imaging. In our case, the diagnosis of stercoral perforation was made only on CT. Although this is not the first such case to be reported, it is significant as preoperative CT imaging was influential not only in determining the aetiology of the abdominal distension seen on the plain film, but also in detecting the pneumoperitoneum which was not evident clinically or on plain radiographs.

  6. Multiconfiguration hartree-fock theory for pseudorelativistic systems: The time-dependent case

    KAUST Repository

    Hajaiej, Hichem

    2014-03-01

    In [Setting and analysis of the multi-configuration time-dependent Hartree-Fock equations, Arch. Ration. Mech. Anal. 198 (2010) 273-330] the third author has studied in collaboration with Bardos, Catto and Mauser the nonrelativistic multiconfiguration time-dependent Hartree-Fock system of equations arising in the modeling of molecular dynamics. In this paper, we extend the previous work to the case of pseudorelativistic atoms. We show the existence and the uniqueness of global-in-time solution to the underlying system under technical assumptions on the energy of the initial data and the charge of the nucleus. Moreover, we prove that the result can be extended to the case of neutron stars when the number of electrons is less than a critical number N cr. © 2014 World Scientific Publishing Company.

  7. Clonazepam as Agonist Substitution Treatment for Benzodiazepine Dependence: A Case Report

    Directory of Open Access Journals (Sweden)

    Angelo Giovanni Icro Maremmani

    2013-01-01

    Full Text Available Nowadays, the misuse of benzodiazepines (BZDs is a cause for a serious concern among pharmacologically inexperienced patients, whether treated or untreated, that could lead to significant complications, including tolerance, dependence, and addiction. We present a case report in which an Italian patient affected by anxiety disorder and treated with BZDs presented a severe case of dependence on BZDs. We treated him according to an agonist substitution approach, switching from the abused BZD to a slow-onset, long-acting, high potency agonist (clonazepam, and looking at the methadone treatment model as paradigm. We decided to use clonazepam for its pharmacokinetic properties. The advantage of choosing a slow-onset, long-lasting BZD for the treatment of our patient was that it led us to a remarkable improvement in the clinical situation, including the cessation of craving, absence of withdrawal symptoms, reduced anxiety, improvements in social functioning, and a better cognition level.

  8. Thermoplasticity of coupled bodies in the case of stress-dependent heat transfer

    Science.gov (United States)

    Kilikovskaya, O. A.

    1987-01-01

    The problem of the thermal stresses in coupled deformable bodies is formulated for the case where the heat-transfer coefficient at the common boundary depends on the stress-strain state of the bodies (e.g., is a function of the normal pressure at the common boundary). Several one-dimensional problems are solved in this formulation. Among these problems is the determination of the thermal stresses in an n-layer plate and in a two-layer cylinder.

  9. Pyridoxine-dependent seizures: 10-year follow-up of eight cases.

    Science.gov (United States)

    Koul, Roshan

    2009-01-01

    Eight children with pyridoxine-dependent seizures (PDS) were seen over a period of 10 years. Of those children, 6 are on regular follow-up. Four of the children were seen in one family. All the patients presented with refractory seizures, mainly neonatal status epilepticus. Though PDS is a rare condition, it must be considered in all cases with refractory seizures, particularly in children younger than 3 years. When confirming a diagnosis, oral pyridoxine is as effective as intravenous pyridoxine.

  10. Pyridoxine-dependent seizures: 10-year follow-up of eight cases

    OpenAIRE

    2009-01-01

    Eight children with pyridoxine-dependent seizures (PDS) were seen over a period of 10 years. Of those children, 6 are on regular follow-up. Four of the children were seen in one family. All the patients presented with refractory seizures, mainly neonatal status epilepticus. Though PDS is a rare condition, it must be considered in all cases with refractory seizures, particularly in childrens younger than 3 years. When confirming a diagnosis, oral pyridoxine is as effective as intravenous pyrid...

  11. Vitamin D dependent rickets, diagnostic and therapeutic difficulties: two case reports.

    Science.gov (United States)

    Donghi, Valentina; Di Frenna, Marianna; di Lascio, Alessandra; Chiumello, Giuseppe; Weber, Giovanna

    2011-01-01

    There are two types of vitamin D dependent rickets (VDDR) that cause rickets in children. Vitamin D dependent rickets type 1 (VDDR-I) is caused by an inborn error of vitamin D metabolism, which interferes with renal conversion of calcidiol (25OHD) to calcitriol (1,25(OH)2D) by the enzyme 1alpha-hydroxylase. Vitamin D dependent rickets type 2 (VDDR-II) is caused by a defect in the vitamin D receptor (VDR). We report cases of two African children affected by VDDR-I and VDDR-II, respectively. Establishing an early diagnosis of these genetic forms of rickets is challenging, especially in developing countries where nutritional rickets (NR) is the most common variety of the disease. A prompt diagnosis is necessary to initiate adequate treatment, resolve biochemical features and prevent complications, such as severe deformities that may require surgical intervention.

  12. Time-dependent mean-field games in the superquadratic case

    KAUST Repository

    Gomes, Diogo A.

    2016-04-06

    We investigate time-dependent mean-field games with superquadratic Hamiltonians and a power dependence on the measure. Such problems pose substantial mathematical challenges as key techniques used in the subquadratic case, which was studied in a previous publication of the authors, do not extend to the superquadratic setting. The main objective of the present paper is to address these difficulties. Because of the superquadratic structure of the Hamiltonian, Lipschitz estimates for the solutions of the Hamilton−Jacobi equation are obtained here through a novel set of techniques. These explore the parabolic nature of the problem through the nonlinear adjoint method. Well-posedness is proven by combining Lipschitz regularity for the Hamilton−Jacobi equation with polynomial estimates for solutions of the Fokker−Planck equation. Existence of classical solutions is then established under conditions depending only on the growth of the Hamiltonian and the dimension. Our results also add to current understanding of superquadratic Hamilton−Jacobi equations.

  13. Delirium in the course of dependence upon gamma-butyrolactone (GBL - a case report

    Directory of Open Access Journals (Sweden)

    Łobejko Łukasz

    2016-12-01

    Full Text Available Gamma-butyrolactone (GBL is an organic chemical compound of the lactones group, undergoing biotransformation into gamma-hydroxybutyrate after the intake (GHB. Because of the easy access, low price and fast psychotropic effect, GBL is becoming increasingly popular substance having intoxicating effect. Taking of GBL causes dose-dependent euphoric, sedative, hypnotic effects. Its use can quickly lead to physical dependence with severe course of withdrawal syndromes. Withdrawal symptoms resemble those occurring in the course of addiction to alcohol or benzodiazepines. In some patients, delirium develops during substance withdrawal. There are described severe, life-threatening complications in the course of delirium in GBL-dependent patients. The management of withdrawal syndromes and delirium mainly involves administration of benzodiazepines. In this paper, we present a case of delirium in 24-year-old man addicted to GBL hospitalized in a psychiatric ward. Delirium in this patient went without complications and was successfully managed with diazepam and lorazepam.

  14. Case Report: Intravenous and Oral Pyridoxine Trial for Diagnosis of Pyridoxine-Dependent Epilepsy.

    Science.gov (United States)

    Cirillo, Melissa; Venkatesan, Charu; Millichap, John J; Stack, Cynthia V; Nordli, Douglas R

    2015-07-01

    Pyridoxine-dependent epilepsy is a rare, autosomal recessive, treatable cause of neonatal seizures. Genetic testing can confirm mutations in the ALDH7A1 gene, which encodes antiquitin. To avoid delays in initiating treatment while awaiting confirmatory genetic testing, it is recommended that all neonates with unexplained seizures should receive trial of intravenous (IV) pyridoxine to assess for responsiveness. However, oral pyridoxine is not commonly continued in the absence of the typical EEG changes. Two cases are presented that highlight the potential inadequacy of this single-step approach. One neonate ultimately diagnosed with pyridoxine-dependent seizures had no EEG changes after administration of IV pyridoxine. In contrast, another neonate who did not have this diagnosis had profound EEG changes after pyridoxine administration. We present 2 cases that highlight the difficulties in using initial EEG response to IV pyridoxine in establishing a diagnosis of pyridoxine-dependent seizures in the neonate. Given the availability of biochemical markers and gene testing, we suggest that oral pyridoxine treatment should be continued until biochemical and/or genetic testing has confirmed the presence or absence of pyridoxine-dependent epilepsy.

  15. A case report of inpatient detoxification after kratom (Mitragyna speciosa) dependence.

    Science.gov (United States)

    McWhirter, Laura; Morris, Siobhan

    2010-01-01

    Kratom (Mitragyna speciosa) has been used for medicinal and recreational purposes. It has reported analgesic, euphoric and antitussive effects via its action as an agonist at opioid receptors. It is illegal in many countries including Thailand, Malaysia, Myanmar, South Korea and Australia; however, it remains legal or uncontrolled in the UK and USA, where it is easily available over the Internet. We describe a case of kratom dependence in a 44-year-old man with a history of alcohol dependence and anxiety disorder. He demonstrated dependence on kratom with withdrawal symptoms consisting of anxiety, restlessness, tremor, sweating and cravings for the substance. A reducing regime of dihydrocodeine and lofexidine proved effective in treating subjective and objective measures of opioid-like withdrawal phenomena, and withdrawal was relatively short and benign. There are only few reports in the literature of supervised detoxification and drug treatment for kratom dependence. Our observations support the idea that kratom dependence syndrome is due to short-acting opioid receptor agonist activity, and suggest that dihydrocodeine and lofexidine are effective in supporting detoxification.

  16. Mode of Delivery in Drug-Dependent Pregnant Women: A Case Control Study.

    Science.gov (United States)

    Neves, Ana Raquel; Neves, Fabiane; Santos Silva, Isabel; Almeida, Maria do Céu; Monteiro, Pitorra

    2017-01-01

    Objective. To determine the contribution of drug use during pregnancy to the route of delivery. Methods. A case-control study was conducted at a hospital in Coimbra, Portugal, between 2001 and 2014. Drug-dependent pregnant women (n = 236) were compared with a control group of low risk women (n = 228) in terms of maternal characteristics, obstetric history, pregnancy complications, and labor details. Factors that influenced the mode of delivery were determined. Statistical analysis was performed with SPSS v. 23.0 (IBM Corp.). p values Drug-dependent women presented a lower rate of cesarean delivery (18.2 versus 28.9%, p = 0.006). After adjusting for the factors that were significantly related to the mode of delivery, drug dependency influenced the rate of cesarean section (β = 0.567; 95% CI = 0.328-0.980). Within the drug-dependent group, the mode of delivery was significantly related to previous cesarean or vaginal delivery (p = 0.008 and p drug, route of administration, or substitution maintenance therapy. Conclusions. The drug-dependent group presented a significantly higher rate of vaginal delivery. However, this was not associated with the behavioral factors analyzed. We hypothesize that other social and psychological factors might explain this difference.

  17. Pyridoxine-dependent seizures: a case report and a critical review of the literature.

    Science.gov (United States)

    Gupta, V K; Mishra, D; Mathur, I; Singh, K K

    2001-12-01

    Pyridoxine-dependent seizures are a recognized, although rare, cause of intractable seizures in neonates. Patients with this autosomal recessive disorder have recurrent seizures that are resistant to conventional anticonvulsants but respond dramatically to intravenous administration of pyridoxine. Life-long supplementation with pyridoxine is required to prevent seizure recurrence. In the absence of a biological marker for the disease, clinical diagnosis is often delayed and severe neurological sequelae are common. Herein, we report on the clinical course of a neonate with pyridoxine-dependent seizures. Delayed normalization of the electroencephalogram and a normal developmental outcome (at 15 months of age) on a dose of 10 mg/kg pyridoxine are distinctive features of the present case. We also review recent clinical observations and neurochemical studies that have added to our knowledge of this disorder.

  18. Occult breast cancer with EDTA-dependent pseudothrombocytopenia -a case report-.

    Science.gov (United States)

    Abe, Hajime; Shimizu, Tomoharu; Cho, Hirotomi; Kubota, Yoshihiro; Umeda, Tomoko; Kurumi, Yoshimasa; Tani, Tohru

    2010-05-01

    A case of occult breast cancer with pseudothrombocytopenia (PTCP) is reported. A 50-year-old woman was consulted with a left axillary tumor. Ductal carcinoma was found by the core needle biopsy, and no primary lesion was detected. Her preoperative platelet count, obtained from an ethylene diamine tetraacetic acid (EDTA) sampling bottle, was 3.1 x 10(4) per mL, but she had no history of bleeding problems. A heparinized blood sample showed a normal platelet count of 390 x 10(4) per mL. These findings suggested a diagnosis of occult breast cancer with EDTA-dependent PTCP, and level II axillary lymph node dissection was performed. She received adjuvant chemotherapy and radiotherapy, but she died 2 years and 5 months after the surgery because of lung and brain metastases. Awareness of the phenomenon and knowledge of the underlying physiological principles will enable surgeons to manage patients with EDTA-dependent PTCP appropriately.

  19. Baclofen as relapse prevention in the treatment of gamma-hydroxybutyrate dependence: a case series.

    Science.gov (United States)

    Kamal, Rama M; Loonen, Anton J M; Dijkstra, Boukje A G; De Jong, Cornelis A J

    2015-06-01

    In the last decade, gamma-hydroxybutyrate (GHB) abuse and dependence have increased. It has been reported that GHB dependence has a high rate of relapse, serious complications of intoxication, and a potentially life-threatening withdrawal syndrome. Nevertheless, in clinical practice, there is no known medical treatment to support GHB relapse prevention. We describe a case series of patients who were supported through an off-label treatment with baclofen to avoid a relapse into GHB abuse, for a period of 12 weeks. Nine of 11 patients did not relapse while taking a dose ranging from 30 to 60 mg per day, one patient relapsed after 5 weeks, and one stopped after 7 weeks. Baclofen was well tolerated; patients reported mild side effects such as fatigue, nausea, dry mouth, excessive sweating, and depressive feelings. Although systematic evidence is still lacking, our practice-based experience suggests that treatment with baclofen to assist abstinence might be effective in patients with GHB dependence. Further systematic controlled studies are necessary to establish the exact efficacy and safety of baclofen as relapse prevention for GHB-dependent patients.

  20. Pyridoxine-dependent seizures: 10-year follow-up of eight cases

    Directory of Open Access Journals (Sweden)

    Koul Roshan

    2009-01-01

    Full Text Available Eight children with pyridoxine-dependent seizures (PDS were seen over a period of 10 years. Of those children, 6 are on regular follow-up. Four of the children were seen in one family. All the patients presented with refractory seizures, mainly neonatal status epilepticus. Though PDS is a rare condition, it must be considered in all cases with refractory seizures, particularly in childrens younger than 3 years. When confirming a diagnosis, oral pyridoxine is as effective as intravenous pyridoxine.

  1. Waterpipe smoking and dependence are associated with chronic bronchitis: a case-control study in Lebanon.

    Science.gov (United States)

    Salameh, P; Waked, M; Khoury, F; Akiki, Z; Nasser, Z; Abou Abbass, L; Dramaix, M

    2012-10-01

    Waterpipe smoking and its association with chronic bronchitis has not been assessed in Lebanon. This case-control study in Beirut in 2009/2010 evaluated this relationship: 274 cases of chronic bronchitis and 559 controls without the condition aged > or = 40 years were enrolled. Data were collected by questionnaire on: sociodemographic characteristics, respiratory symptoms, smoking (waterpipe and cigarette) and nicotine dependence. ANOVA, Student, Kruskal-Wallis, chi-squared and Fisher exact tests were used when applicable and logistic regression analysis was carried out. Previous waterpipe smoking (OR = 6.4), previous mixed smoking (OR = 38.03) and current mixed smoking (OR = 7.68) were significantly associated with chronic bronchitis (P bronchitis (OR = 3.74, P 20 WP-years (P bronchitis.

  2. A case of steroid-dependent myeloid granulocytic sarcoma masquerading as Crohn's disease

    Institute of Scientific and Technical Information of China (English)

    Lola Y Kwan; Stephan R Targan; David Q Shih

    2011-01-01

    Small bowel tumors and Crohn's disease are common causes of small bowel obstruction. Early stage neoplasms can easily be mistaken for Crohn's disease. Therefore, thorough work-ups including imaging studies and endoscopic evaluation with biopsies are critical for accurate diagnosis. Here we report a case of an otherwise healthy female with progressive onset of multiple, recurrent obstructive symptoms secondary to terminal ileal narrowing who was referred for management of steroid-dependent Crohn's disease. After thorough evaluation, the diagnosis was revised to myeloid granulocytic sarcoma involving the terminal ileum. In this case, a delay in diagnosis can be detrimental for prognosis, as myeloid granulocytic sarcoma is highly predictive of underlying acute myeloid leukemia and needs urgent referral for chemotherapy and/or resection.

  3. Modeling dependence structure between stock market volatility and sukuk yields: A nonlinear study in the case of Saudi Arabia

    Directory of Open Access Journals (Sweden)

    Nader Naifar

    2016-09-01

    Full Text Available The aim of this paper is to investigate the dependence structure between sukuk (Islamic bonds yields and stock market (returns and volatility in the case of Saudi Arabia. We consider three Archimedean copula models with different tail dependence structures namely Gumbel, Clayton, and Frank. This study shows that the sukuk yields exhibit significant dependence only with stock market volatility. In addition, the dependence structure between sukuk yields and stock market volatility are symmetric and linked with the same intensity.

  4. Dealing with Dependent Uncertainty in Modelling: A Comparative Study Case through the Airy Equation

    Directory of Open Access Journals (Sweden)

    J.-C. Cortés

    2013-01-01

    Full Text Available The consideration of uncertainty in differential equations leads to the emergent area of random differential equations. Under this approach, inputs become random variables and/or stochastic processes. Often one assumes that inputs are independent, a hypothesis that simplifies the mathematical treatment although it could not be met in applications. In this paper, we analyse, through the Airy equation, the influence of statistical dependence of inputs on the output, computing its expectation and standard deviation by Fröbenius and Polynomial Chaos methods. The results are compared with Monte Carlo sampling. The analysis is conducted by the Airy equation since, as in the deterministic scenario its solutions are highly oscillatory, it is expected that differences will be better highlighted. To illustrate our study, and motivated by the ubiquity of Gaussian random variables in numerous practical problems, we assume that inputs follow a multivariate Gaussian distribution throughout the paper. The application of Fröbenius method to solve Airy equation is based on an extension of the method to the case where inputs are dependent. The numerical results show that the existence of statistical dependence among the inputs and its magnitude entails changes on the variability of the output.

  5. A positive event dependence model for self-controlled case series with applications in postmarketing surveillance.

    Science.gov (United States)

    Simpson, Shawn E

    2013-03-01

    A primary objective in the application of postmarketing drug safety surveillance is to ascertain the relationship between time-varying drug exposures and recurrent adverse events (AEs) related to health outcomes. The self-controlled case series (SCCS) method is one approach to analysis in this context. It is based on a conditional Poisson regression model, which assumes that events at different time points are conditionally independent given the covariate process. This requirement is problematic when the occurrence of an event can alter the future event risk. In a clinical setting, for example, patients who have a first myocardial infarction (MI) may be at higher subsequent risk for a second. In this work, we propose the positive dependence self-controlled case series (PD-SCCS) method: a generalization of SCCS that allows the occurrence of an event to increase the future event risk, yet maintains the advantages of the original model by controlling for fixed baseline covariates and relying solely on data from cases. As in the SCCS model, individual-level baseline parameters drop out of the PD-SCCS likelihood. Data sources used for postmarketing surveillance can contain tens of millions of people, so in this situation it is particularly advantageous that PD-SCCS avoids doing a costly estimation of individual parameters. We develop expressions for large sample inference and optimization for PD-SCCS and compare the results of our generalized model with the more restrictive SCCS approach. Copyright © 2013, The International Biometric Society.

  6. Electronic friction near metal surfaces: a case where molecule-metal couplings depend on nuclear coordinates

    CERN Document Server

    Dou, Wenjie

    2016-01-01

    We derive an explicit form for the electronic friction as felt by a molecule near a metal surface for the general case that molecule-metal couplings depend on nuclear coordinates. Our work generalizes a previous study by von Oppen et al [Beilstein Journal of Nanotechnology, 3, 144, 2012], where we now go beyond the Condon approximation (i.e. molecule-metal couplings are not held constant). Using a non-equilibrium Green's function formalism in the adiabatic limit, we show that fluctuating metal-molecule couplings lead to new frictional damping terms and random forces, plus a correction to the potential of mean force. Numerical tests are performed and compared with a modified classical master equation; our results indicate that violating the Condon approximation can have a large effect on dynamics.

  7. Electronic friction near metal surfaces: A case where molecule-metal couplings depend on nuclear coordinates

    Science.gov (United States)

    Dou, Wenjie; Subotnik, Joseph E.

    2017-03-01

    We derive an explicit form for the electronic friction as felt by a molecule near a metal surface for the general case that molecule-metal couplings depend on nuclear coordinates. Our work generalizes a previous study by von Oppen et al. [Beilstein J. Nanotechnol. 3, 144 (2012)], where we now go beyond the Condon approximation (i.e., molecule-metal couplings are not held constant). Using a non-equilibrium Green's function formalism in the adiabatic limit, we show that fluctuating metal-molecule couplings lead to new frictional damping terms and random forces, plus a correction to the potential of mean force. Numerical tests are performed and compared with a modified classical master equation; our results indicate that violating the Condon approximation can have a large effect on dynamics.

  8. Globalization of the pharmaceutical industry and the growing dependency of developing countries: the case of Turkey.

    Science.gov (United States)

    Semin, Semih; Güldal, Dilek

    2008-01-01

    In developing countries, the effect of globalization on the pharmaceutical sector has resulted in a decrease in exportation and domestic production, accompanied by an increase in importation of pharmaceuticals and a rise in prices and expenditures. As an example of a developing country, Turkey has been facing the long-standing and increasing pressure of global regulations placed on its pharmaceutical sector. This has led to an increasing dependency on multinational companies and a gradual deterioration of an already weakened domestic pharmaceutical sector. This case study of Turkey offers points to consider in the world of increasing globalization, as it offers lessons on ways of examining the effects of globalization on the pharmaceutical industry of developing countries.

  9. Comparison of nested case-control and survival analysis methodologies for analysis of time-dependent exposure

    Directory of Open Access Journals (Sweden)

    Platt Robert W

    2005-01-01

    Full Text Available Abstract Background Epidemiological studies of exposures that vary with time require an additional level of methodological complexity to account for the time-dependence of exposure. This study compares a nested case-control approach for the study of time-dependent exposure with cohort analysis using Cox regression including time-dependent covariates. Methods A cohort of 1340 subjects with four fixed and seven time-dependent covariates was used for this study. Nested case-control analyses were repeated 100 times for each of 4, 8, 16, 32, and 64 controls per case, and point estimates were compared to those obtained using Cox regression on the full cohort. Computational efficiencies were evaluated by comparing central processing unit times required for analysis of the cohort at sizes 1, 2, 4, 8, 16, and 32 times its initial size. Results Nested case-control analyses yielded results that were similar to results of Cox regression on the full cohort. Cox regression was found to be 125 times slower than the nested case-control approach (using four controls per case. Conclusions The nested case-control approach is a useful alternative for cohort analysis when studying time-dependent exposures. Its superior computational efficiency may be particularly useful when studying rare outcomes in databases, where the ability to analyze larger sample sizes can improve the power of the study.

  10. Managing Disasters Using Pressure Dependent Demand Analysis – Case Study of Shirpur Town

    Directory of Open Access Journals (Sweden)

    Madhuri Mulay

    2016-12-01

    Full Text Available Water is the most essential component for sustaining lives of humans and other living creatures. Supplying potable water with adequate residual pressure is a fundamental responsibility of city administration, which they do during normal conditions. But sometimes, abnormal conditions are formed resulting pressure deficient conditions during the daily operations of water distribution networks. These are caused due to common occurrences such as pump failure, pipe bursts, and isolation of major pipes from the system for planned maintenance work and excessive firefighting demands. Total water stop conditions may arise, when the major source supplying water to the city fails in natural disaster such as floods, Tsunami, earthquake or manmade disaster such as terrorist attack. Unlike the pipe failure, longer time is required for restoring water in case of source failure condition. In such situations, the quantity of water is generally decreased and the water distribution systems (WDS may not be able to satisfy all consumers’ demands. In this context, the assumption that all demands are fully satisfied regardless of the pressure in the system becomes unreasonable. A realistic behavior of the network performance can only be attained by considering demands to be pressure dependent. This paper aims to describe how pressure dependent demand analysis is useful for the simulation of disaster scenario due to source failure of the Shirpur town. The simulation of failure scenario is carried out using WaterGEMs software. The paper also aims to prepare the action plans for the recovery of water supply in such crisis conditions.

  11. [A case of Sjögren's syndrome associated with EDTA-dependent pseudothrombocytopenia].

    Science.gov (United States)

    Hosokawa, T; Hinoda, Y; Imai, K

    1997-04-01

    A 69-year-old woman was admitted to Department of Orthopedic Surgery in our hospital because of lumbago on April 4, 1995. Since laboratory data showed thrombocytopenia (platelet count 2.1 x 10(4)/mm3) on admission, she was transferred to Department of Internal Medicine for further examination on April 11. She noticed abnormal taste and showed remarkable sicca symptoms. Schirmer test, gum test and electrogustometry were positive, and parotid sialogram findings and histology of minor salivary glands of the lip were compatible with those of typical Sjögren's syndrome. Thus, she was diagnosed as Sjögren's syndrome. Although the antibodies to SS-A/SS-B were negative in her serum, anti-nuclear and anti-centromere antibodies were strongly positive (x1280). Serum IgM level was increased. The decreased platelet count was observed when EDTA was used as anticoagulant. The binding activity of the anti-platelet antibody activated by EDTA was dependent on temperature. Its immunoglobulin class was shown to be IgM by enzyme-labelled antibody method. We here report a case of Sjögren's syndrome associated with EDTA-dependent pseudothrombocytopenia.

  12. A Case Report of Clonazepam Dependence: Utilization of Therapeutic Drug Monitoring During Withdrawal Period.

    Science.gov (United States)

    Kacirova, Ivana; Grundmann, Milan; Silhan, Petr; Brozmanova, Hana

    2016-03-01

    Clonazepam is long-acting benzodiazepine agonist used in short-acting benzodiazepine withdrawal; however, recent observations suggest the existence of its abuse. We demonstrate a 40-year-old man with a 20-year history of psychiatric care with recently benzodiazepine dependence (daily intake of ∼60 mg of clonazepam and 10 mg of alprazolam). High serum levels of both drugs were analyzed 3 weeks before admission to hospitalization (clonazepam 543.9 ng/mL, alprazolam 110 ng/mL) and at the time of admission (clonazepam 286.2 ng/mL, alprazolam 140 ng/mL) without any signs of benzodiazepine intoxication. Gradual withdrawal of clonazepam with monitoring of its serum levels and increase of gabapentin dose were used to minimize physical signs and symptoms of clonazepam withdrawal. Alprazolam was discontinued promptly. Clinical consequences of the treatment were controllable tension, intermittent headache, and rarely insomia. It is the first case report showing utilization of therapeutic drug monitoring during withdrawal period in the patient with extreme toleration to severe benzodiazepine dependence.

  13. Stimulation dependent induction of fear and depression in deep brain stimulation: a case report

    Directory of Open Access Journals (Sweden)

    Sabolek Michael

    2009-09-01

    Full Text Available Abstract Introduction Psychiatric side effects of deep brain stimulation are not uncommon. It is often limited to transient mood alterations. We report for the first time a case of acute stimulation-dependent fear during intraoperative test stimulation. Case presentation During test stimulation for electrode placement to the left subthalamic nucleus, a 58-year-old caucasian man with Parkinson's disease developed a severe reproducible feeling of fear together with elevated heart rate and sweating. Postoperatively, the patient developed a therapy refractory major depression in spite of excellent motor-control. Reprogramming the stimulator using a more rostral contact resulted in an abrupt and complete disappearance of the depressive syndrome. Conclusion Postoperative re-evaluation of the stimulation site of the patient inducing acute fear by analyzing his intraoperative microrecordings and Talairach coordinates revealed stimulation within his right substantia nigra. The contrast analysis of the postoperative stimulation site suggests induction of depression in the patient by stimulation of the caudal part of his subthalamic nucleus. Acute psychiatric side effects of deep brain stimulation are relatively rare but must not be overlooked while concentrating on the improvement of motor deficit.

  14. Time-Dependent Photoionization of Gaseous Nebulae: The Pure Hydrogen Case

    Science.gov (United States)

    Garcia, J.; Elhoussieny, E. E.; Bautista, M. A.; Kallman, Timothy R.

    2013-01-01

    We study the problem of time-dependent photoionization of low density gaseous nebulae subjected to sudden changes in the intensity of ionizing radiation. To this end, we write a computer code that solves the full timedependent energy balance, ionization balance, and radiation transfer equations in a self-consistent fashion for a simplified pure hydrogen case. It is shown that changes in the ionizing radiation yield ionizationthermal fronts that propagate through the cloud, but the propagation times and response times to such fronts vary widely and nonlinearly from the illuminated face of the cloud to the ionization front (IF). IFthermal fronts are often supersonic, and in slabs initially in pressure equilibrium such fronts yield large pressure imbalances that are likely to produce important dynamical effects in the cloud. Further, we studied the case of periodic variations in the ionizing flux. It is found that the physical conditions of the plasma have complex behaviors that differ from any steady-state solution. Moreover, even the time average of ionization and temperature is different from any steady-state case. This time average is characterized by overionization and a broader IF with respect to the steady-state solution for a mean value of the radiation flux. Around the time average of physical conditions there is a large dispersion in instantaneous conditions, particularly across the IF, which increases with the period of radiation flux variations. Moreover, the variations in physical conditions are asynchronous along the slab due to the combination of nonlinear propagation times for thermal frontsIFs and equilibration times.

  15. Poorer prognosis with ethylenediaminetetraacetic acid-dependent pseudothrombocytopenia: a single-center case-control study.

    Science.gov (United States)

    Ohashi-Fukuda, Naoko; Inokuchi, Ryota; Sato, Hajime; Nakamura, Kensuke; Iwagami, Masao; Wada, Tomoki; Jona, Masahiro; Hisasue, Takashi; Nakajima, Susumu; Yahagi, Naoki

    2015-04-01

    In ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia (PTCP), automated platelet counts are lower than actual counts because of EDTA-induced aggregation. Factors contributing to the incidence of EDTA-PTCP are unknown, and no study has assessed the prognosis of EDTA-PTCP patients. This retrospective study assessed characteristics in EDTA-PTCP patients and matched controls to determine differences in prognosis. A retrospective case-control study was designed. From the University of Tokyo Hospital database, we identified patients diagnosed with EDTA-PTCP between 2009 and 2012, and performed 1:2 case:control matching for age and sex. A control group of sex- and age-matched patients was selected at random from the same database. We investigated differences in the frequency of complications, medication history, and blood transfusion history between the groups at the time of blood collection. Prognosis was evaluated using multivariate Cox regression analysis adjusting for age, sex, autoimmune disease, liver disease, and malignant tumor. We identified 104 EDTA-PTCP patients and 208 matched controls. The median age was 69.0 years (interquartile range: 54-76), with men comprising 51%. EDTA-PTCP patients had a higher frequency of malignant tumor and a lower frequency of hypertension and diabetes than controls. After adjustment for background factors, prognosis of EDTA-PTCP patients was significantly poorer than controls (hazard ratio, 11.8; 95% confidence intervals, 2.62-53.54). In conclusion, EDTA-PTCP patients had higher mortality, and EDTA-PTCP may need to be recognized as an indicator of worse prognosis.

  16. Food-dependent exercise-induced anaphylaxis: a case related to chickpea ingestion and review.

    Science.gov (United States)

    Wong, Chet G; Mace, Sean R

    2007-12-15

    : Food-dependent exercise-induced anaphylaxis (FDEIA) is recognized as a distinct category of exercise-induced anaphylaxis (EIA) but is very likely underdiagnosed. This report describes a 41-year-old Indian woman who experienced two separate episodes of anaphylaxis while dancing after she had eaten chickpea-containing foods. The chickpea, a small legume, is a staple ingredient in culinary traditions from around the world, especially in India, the Middle East, and North Africa. Chickpea-containing dishes are also becoming more widespread in the Western world with the growing popularity of South Asian, Middle Eastern, and African cuisines. It is important to consider FDEIA in cases of unexplained anaphylaxis as reactions can occur several hours after ingesting the culprit food(s). Furthermore, no reaction occurs if a sensitized individual eats the culprit food(s) without exercising afterward; therefore, triggering foods can easily be overlooked. Current ideas on the pathophysiology, predisposing factors, workup, and treatment of FDEIA are also summarized here.

  17. Food-Dependent Exercise-Induced Anaphylaxis: A Case Related to Chickpea Ingestion and Review

    Directory of Open Access Journals (Sweden)

    Wong Chet G

    2007-12-01

    Full Text Available Food-dependent exercise-induced anaphylaxis (FDEIA is recognized as a distinct category of exercise-induced anaphylaxis (EIA but is very likely underdiagnosed. This report describes a 41-year-old Indian woman who experienced two separate episodes of anaphylaxis while dancing after she had eaten chickpea-containing foods. The chickpea, a small legume, is a staple ingredient in culinary traditions from around the world, especially in India, the Middle East, and North Africa. Chickpea-containing dishes are also becoming more widespread in the Western world with the growing popularity of South Asian, Middle Eastern, and African cuisines. It is important to consider FDEIA in cases of unexplained anaphylaxis as reactions can occur several hours after ingesting the culprit food(s. Furthermore, no reaction occurs if a sensitized individual eats the culprit food(s without exercising afterward; therefore, triggering foods can easily be overlooked. Current ideas on the pathophysiology, predisposing factors, workup, and treatment of FDEIA are also summarized here.

  18. Ethylenediaminetetraacetic acid-dependent pseudothrombocytopenia associated with neuroendocrine carcinoma: A case report.

    Science.gov (United States)

    Kim, Hee Jun; Moh, In Ho; Yoo, Hana; Son, Seungyeon; Jung, DA Hye; Lee, Hun Gu; Han, Dong Hee; Park, Jae Hyun; Kim, Hyeong Su; Kim, Jung Han

    2012-07-01

    Ethylenediaminetetraacetic acid-dependent pseudothrombocytopenia (EDTA-PTCP) is an in vitro phenomenon of EDTA-induced platelet aggregation at room temperature. This phenomenon consists of platelet clumping due to anti-platelet antibodies in blood anticoagulated with EDTA. It has been reported in patients with various diseases, including sepsis, multiple myeloma, acute myocardial infarction and breast cancer. Since unrecognized EDTA-PTCP may lead to inappropriate treatment, it should always be considered as a possible cause in patients with low platelet counts. This study identified a case of transient EDTA-PTCP in a patient with neuroendocrine carcinoma of the stomach. In the present study, a 50-year-old male presented with epigastric pain and a weight loss of 15 kg. The patient presented with EDTA-PTCP and was diagnosed with neuroendocrine carcinoma of the stomach. Following systemic chemotherapy, the tumor showed a marked regression and the EDTA-PTCP disappeared. The mechanism by which this occurred is not clear but an association of EDTA-PTCP with neuroendocrine carcinoma is strongly suggested.

  19. A duality approach to the worst case value at risk for a sum of dependent random variables with known covariances

    OpenAIRE

    Brice Franke; Michael Stolz

    2009-01-01

    We propose an approach to the aggregation of risks which is based on estimation of simple quantities (such as covariances) associated to a vector of dependent random variables, and which avoids the use of parametric families of copulae. Our main result demonstrates that the method leads to bounds on the worst case Value at Risk for a sum of dependent random variables. Its proof applies duality theory for infinite dimensional linear programs.

  20. DEPENDABLE PRIVACY REQUIREMENTS BY AGILE MODELED LAYERED SECURITY ARCHITECTURES – WEB SERVICES CASE STUDY

    Directory of Open Access Journals (Sweden)

    M.Upendra Kumar

    2011-07-01

    Full Text Available Software Engineering covers the definition of processes, techniques and models suitable for its environment to guarantee quality of results. An important design artifact in any software development project is the Software Architecture. Software Architecture’s important part is the set of architectural design rules. A primary goal of the architecture is to capture the architecture design decisions. An important part of these design decisions consists of architectural design rules In an MDA (Model-Driven Architecture context, the design of the system architecture is captured in the models of the system. MDA is known to be layered approach for modeling the architectural design rules and uses design patterns to improve the quality of software system. And to include the security to the software system, security patterns are introduced that offer security at the architectural level. More over, agile software development methods are used to build secure systems. There are different methods defined in agile development as extreme programming (XP, scrum, feature driven development (FDD, test driven development (TDD, etc. Agile processing is includes the phases as agile analysis, agile design and agile testing. These phases are defined in layers of MDA to provide security at the modeling level which ensures that security at the system architecture stage will improve the requirements for that system. Agile modeled Layered Security Architectures increase the dependability of the architecture in terms of privacy requirements. We validate this with a case study of dependability of privacy of Web Services Security Architectures, which helps for secure service oriented security architecture. In this paper the major part is given to model architectural design rules using MDA so that architects and developers are responsible to automatic enforcement on the detailed design and easy to understand and use by both of them. This MDA approach is implemented in use of

  1. [An autopsied case of insulin dependent diabetes mellitus complicated by chronic thyroiditis and chronic hepatitis].

    Science.gov (United States)

    Mori, Y; Yokoyama, J; Nohara, T; Mimura, A; Takeishi, M; Yoshigoe, F; Akiyama, M; Ikeda, Y; Isogai, Y; Tokuda, T

    1989-11-20

    A deceased 59-year-old woman with insulin dependent diabetes mellitus complicated by chronic thyroiditis and chronic hepatitis was autopsied. She had had diabetes mellitus since she was 30 years old, and insulin therapy was started at 34 years. Laboratory findings were as follows: s-GOT 85, s-GPT 31, gamma-globulin 2.45 g/dl. Immunological tests were positive for anti-smooth muscle antibody and anti-ENA antibody with high titers of antithyroglobulin and anti-microsome antibodies. HLA analysis revealed the presence of DR-4. The thyroid biopsy specimen showed microscopic features characteristic of chronic thyroiditis at 52 years of age. She had been repeatedly admitted for the control of diabetes mellitus. She was admitted for the 9th time in June, 1987 following complaints of abdominal pain. After admission, her general condition became gradually worse, and she died of peritonitis in September, 1987. Pathological examination of the liver revealed an expansion of fibrous tissue on Glisson's capsule accompanied by lymphocytic infiltration and was diagnosed to be chronic inactive hepatitis. As for the thyroid gland, fibrous tissue replaced an extensive area of the thyroid gland, and normal thyroid tissue was not observed. Lymphocytic infiltration was less in comparison with that in the previous biopsy. As for the pancreas, atrophy of exocrine pancreatic tissue and fibrous change in interstitial tissue was observed. Lymphocytic infiltration was also seen in the interstitial exocrine tissue but not in the islet. Immunohistochemical examination of the islets using anti-insulin, glucagon and somatostatin antibodies by ABC peroxidase method showed the selective disappearance of B cells in the islets. The pathological changes in the thyroid gland, liver and pancreas suggest that autoimmune mechanism may be involved in the pathogenesis of chronic thyroiditis, chronic hepatitis and IDDM with exocrine pancreatic impairment in this case.

  2. Case report: vitamin D-dependent rickets type 1 caused by a novel CYP27B1 mutation.

    Science.gov (United States)

    Füchtbauer, Laila; Brusgaard, Klaus; Ledaal, Pål; Frost, Morten; Frederiksen, Anja L

    2015-12-01

    Vitamin D-dependent rickets type 1 VDDR-1 is a recessive inherited disorder with impaired activation of vitamin D, caused by mutations in CYP27B1. We present long-time follow-up of a case with a novel mutation including high-resolution peripheral quantitative computed tomography of the bone. Adequate treatment resulted in a normalized phenotype.

  3. Time-Dependent Mean-Field Games in the Subquadratic Case

    KAUST Repository

    Gomes, Diogo A.

    2014-10-14

    In this paper we consider time-dependent mean-field games with subquadratic Hamiltonians and power-like local dependence on the measure. We establish existence of classical solutions under a certain set of conditions depending on both the growth of the Hamiltonian and the dimension. This is done by combining regularity estimates for the Hamilton-Jacobi equation based on the Gagliardo-Nirenberg interpolation inequality with polynomial estimates for the Fokker-Planck equation. This technique improves substantially the previous results on the regularity of time-dependent mean-field games.

  4. Resolution dependence of uncertainties in gridded emission inventories: a case study in Hebei, China

    Science.gov (United States)

    Zheng, Bo; Zhang, Qiang; Tong, Dan; Chen, Chuchu; Hong, Chaopeng; Li, Meng; Geng, Guannan; Lei, Yu; Huo, Hong; He, Kebin

    2017-01-01

    Gridded emission inventories are essential inputs for chemical transport models and climate models. Spatial proxies are applied to allocate emissions from regional totals to spatially resolved grids when the exact locations of emissions are absent, with additional uncertainties arising due to the spatial mismatch between the locations of emissions and spatial proxies. In this study, we investigate the impact of spatial proxies on the accuracy of gridded emission inventories at different spatial resolutions by comparing gridded emissions developed from different spatial proxies (proxy-based inventory) with a highly spatially disaggregated bottom-up emission inventory developed from the extensive use of locations of emitting facilities (bottom-up inventory) in Hebei Province, China. We find that proxy-based inventories are generally comparable to bottom-up inventories for grid sizes larger than 0.25° because spatial errors are largely diminished at coarse resolutions. However, for gridded emissions with finer resolutions, large positive biases in urban centers and negative biases in suburban and rural regions are identified in proxy-based inventories and are then propagated into significant biases in urban-scale chemical transport modeling. Compared to bottom-up inventories, the use of proxy-based emissions exhibits similar modeling results, with biases varying from 3 to 13 % when predicting surface concentrations of different pollutants at 36 km resolution and an additional 8-73 % at 4 km resolution. The resolution dependence of uncertainties in proxy-based gridded inventories can be explained by the decoupling of emission facility locations from spatial surrogates, especially because industry facilities tend to be located away from urban centers. This distance results in a divergence between emission distributions and the allocation of proxies on smaller grids. The decoupling effects are weakened when the grid size increases to cover both urban and rural regions

  5. Baclofen as relapse prevention in the treatment of gamma-hydroxybutyrate dependence: a case series

    NARCIS (Netherlands)

    Kamal, R.M.; Loonen, A.J.; Dijkstra, B.A.; Jong, C.A.J. de

    2015-01-01

    In the last decade, gamma-hydroxybutyrate (GHB) abuse and dependence have increased. It has been reported that GHB dependence has a high rate of relapse, serious complications of intoxication, and a potentially life-threatening withdrawal syndrome. Nevertheless, in clinical practice, there is no kno

  6. Mitigating the risk of extreme water scarcity and dependency: the case of Jordan

    NARCIS (Netherlands)

    Schyns, J.F.; Hamaideh, A.; Hoekstra, A.Y.; Mekonnen, M.M.; Schyns, M.

    2015-01-01

    Jordan faces great internal water scarcity and pollution, conflict over trans-boundary waters, and strong dependency on external water resources through trade. This paper analyzes these issues and subsequently reviews options to reduce the risk of extreme water scarcity and dependency. Based on esti

  7. [A case of late-onset SLE complicated with EDTA-dependent pseudothrombocytopenia].

    Science.gov (United States)

    Irisawa, A; Kaise, S; Kumada, Y; Sato, Y; Nishimaki, T; Kasukawa, R; Moritoh, T

    1992-10-01

    A 57-year-old man was admitted to our clinic with complaints of proximal myalgia in extremities. He was diagnosed as late-onset SLE based on the findings of pleuritis, pericarditis, arthritis and antibodies to DNA and cardiolipin. Aggregation of the platelets and the decreased counts of platelets were observed when EDTA was used as anticoagulant for the blood tests. However, the platelet aggregation was not noted with normal counts of platelets when Heparin-Theophylline was used as anticoagulant. From this observation, EDTA-dependent pseudothrombocytopenia was diagnosed and IgM class of EDTA-dependent anti-platelet antibody was detected by means of flow cytometry. Administration of prednisolone at 40mg/day reduced the symptoms and EDTA-dependent pseudothrombocytopenia, and EDTA-dependent anti-platelet antibody disappeared. His clinical course suggested that EDTA-dependent pseudothrombocytopenia was closely associated with the disease activity of SLE.

  8. Targeted rehabilitation reduces visual dependency and improves balance in severe traumatic brain injury: a case study.

    Science.gov (United States)

    Kaski, Diego; Buttell, Joseph; Greenwood, Richard

    2017-01-23

    To further understand the mechanisms underlying gait impairment following traumatic brain injury. A 58-year-old man presented with marked unsteadiness and motion sensitivity following a severe traumatic brain injury. He underwent a 6-week inpatient rehabilitation program focused on re-weighting and subsequently re-integrating ascending interoceptive information, by gradual reduction of maladaptive visual fixation techniques. We report clinical neurological outcomes and measures of functional outcome, as well as an objective assessment of visual dependency (the rod and disk test) at baseline and after the rehabilitation. Clinically, the patient had gait unsteadiness exacerbated by visual motion. A significant reduction in visual dependency occurred with tailored multi-disciplinary rehabilitation via gradual removal of visual fixation strategies that the patient had developed to maintain balance (t-test; p visual dependency in the generation of maladaptive gait strategies following brain injury. Our data suggest assessing and treating visual dependency to be an important component of gait rehabilitation after traumatic brain injury. Implications for rehabilitation Whilst gait disturbance in TBI is multifactorial, abnormal visual dependency may be important but under-recognised component of the disorder. Visual dependency can be easily and objectively assessed by the bedside in patients using a dynamic rod and disc test. Tailored rehabilitation with gradual reduction of maladaptive visual fixation can reduce visual dependency and contribute to improved gait and balance following TBI.

  9. Time-Dependant Responses of High-Definition Induction Log and Case Studies

    Directory of Open Access Journals (Sweden)

    Jianhua Zhang

    2014-01-01

    Full Text Available The process of drilling mud filtrate invading into a reservoir is time dependant. It causes dynamic invasion profiles of formation parameters such as water saturation, salinity, and formation resistivity. Thus, the responses of a high-definition induction log (HDIL tool are time dependent. The logging time should be considered as an important parameter during logging interpretation for the purposes of determining true formation resistivity, estimating initial water saturation, and evaluating a reservoir. The time-dependent HDIL responses are helpful for log analysts to understand the invasion process physically. Field examples were illustrated for the application of present method.

  10. Pyridoxine Dependent Seizures-Report Of A Case And Brief Review Of Literature

    OpenAIRE

    2002-01-01

    Pyridoxine-dependent seizure is a rare autosornal recessive disorder that usually presents as neonatal intractable seizures. This syndrome is due to an inborn abnormality of the enzyme glutamic acid decarboxylase, which results in reduced pyridoxine-dependent synthesis of the inhibitory neurotransmitter gamma amino butyric acid. We report a girl child who had seizures on the second post natal day which was controlled with oral pyridoxine. She had status epilepticus twice when the drug was ...

  11. Mitigating the Risk of Extreme Water Scarcity and Dependency: The Case of Jordan

    OpenAIRE

    Schyns, Joep F.; Arwa Hamaideh; Arjen Y. Hoekstra; Mekonnen, Mesfin M.; Marlou Schyns

    2015-01-01

    Jordan faces great internal water scarcity and pollution, conflict over trans-boundary waters, and strong dependency on external water resources through trade. This paper analyzes these issues and subsequently reviews options to reduce the risk of extreme water scarcity and dependency. Based on estimates of water footprint, water availability, and virtual water trade, we find that groundwater consumption is nearly double the groundwater availability, water pollution aggravates blue water sca...

  12. Inflation asymmetry, menu costs and aggregation bias – A further case for state dependent pricing

    OpenAIRE

    Karádi, Péter; Reiff, Ádám

    2010-01-01

    Asymmetric inflation response to aggregate shocks is an identifying macro-prediction of state dependent pricing models with trend inflation (Ball and Mankiw, 1994). The paper uses the natural experiment of symmetric value-added tax (VAT) changes in Hungary with highly asymmetric inflation responses to provide further evidence for state-dependent pricing and for the Ball-Mankiw conjecture. The paper shows, furthermore, that while a standard menu cost model like that of Golosov and Lucas (2007)...

  13. Specific Oral Tolerance Induction Using IFN-Gamma in 2 Cases of Food-Dependent Exercise-Induced Anaphylaxis

    Directory of Open Access Journals (Sweden)

    Geunwoong Noh

    2013-01-01

    Full Text Available Anaphylaxis induced by exercise after the intake of certain foods is referred to as food-dependent exercise-induced anaphylaxis (FDEIA. Only the preventive medication such as oral sodium cromoglycate and oral combined cetirizine-montelukast was tried in FDEIA. Specific oral tolerance induction (SOTI using IFN-gamma was tried in 2 cases of FDEIA for wheat. Merely, exercise accompanied every treatment just after the intake of allergenic foods during treatment. Patients acquired tolerance for wheat in both cases successfully. After treatment, two patients take wheat in their food living freely. Conclusively, SOTI using IFN-gamma was effective as the causative treatment for allergenic foods in FDEIA.

  14. Cocaine-induced Psychosis and Brain-derived Neurothrophic Factor in Patients with Cocaine Dependence: Report of Two Cases

    Science.gov (United States)

    Roncero, Carlos; Palma-Álvarez, Raul Felipe; Ros-Cucurull, Elena; Barral, Carmen; Gonzalvo, Begoña; Corominas-Roso, Margarida; Casas, Miguel; Grau-López, Lara

    2016-01-01

    Brain-derived neurotrophic factor (BDNF) is linked to numerous brain functions. In addition, BDNF alterations contribute to neurological, mental, and addictive disorders. Cocaine dependence has received much attention recently due to its prevalence and psychological effects. Symptoms of psychosis are one of the most serious adverse events precipitated by cocaine use. It is particularly important to identify patients at risk of developing cocaine-induced psychosis (CIP). We described two cases of patients with cocaine dependence who presented with CIP and had changes in their BDNF levels during the psychotic episode. BDNF levels were initially low in both patients, and then decreased by more than 50% in association with CIP. The relationship between BDNF and psychosis is described in the literature. These cases revealed that BDNF levels decreased during a CIP episode and, thus, it is necessary to investigate BDNF and its relationship with CIP further. PMID:26792050

  15. Industrial symbiosis as a countermeasure for resource dependent city: a case study of Guiyang, China

    DEFF Research Database (Denmark)

    Li, Hong; Dong, Liang; Ren, Jingzheng

    2015-01-01

    of sustainability and economy transition solutions become more and more important. Under this condition, this study aims to conduct a comprehensive review on the major projects for a more sustainable future in China's national resource dependent cities and propose a countermeasure for the sustainability transition...... based on the industrial symbiosis concept. Firstly, an investigation on the panoramic view, challenges, transiting policies of China's resource dependent cities' project has been carried out. Subsequently, Guiyang city in Guizhou province of China, as a typical resource dependent city, has been chosen...... as example of industrial and regional symbiosis focusing on the integration and symbiosis of coal, electricity, aluminum, phosphor chemical, iron/steel industry and urban. Then, a quantitative assessment on the environmental benefits has been conducted based on material flow analysis approach. Results...

  16. Treatment of steroid dependant cases of recurrent lepra reaction with a combination of thalidomide and clofazimine.

    Science.gov (United States)

    Ramu, G; Girdhar, A

    1979-10-01

    22 Adult Male Lepromatous patients suffering from recurrent lepra reaction have been allotted to either a regimen of combined treatment with Clofazimine and Thalidomide alone. The initial dosage of either of the drugs was 300 mg daily administered in divided doses of 100 mg three times a day. The preliminary assessment of the ongoing study, indicates that the combined treatment controls the reactional state more rapidly than monotherapy with Thalidomide alone. Results of treatment as regards relief of neuritis and arthritis are particularly gratifying. Four month.ases relapsed into reactional status from 2 days to 15 days. 5 cases on the combined therapy relapsed from one to three months. Three other cases required six months and three cases 8 months treatment before clofazimine could be withdrawn. It would appear that a maintenance therapy of 6 months with flofazimine would be necessary for maintaining the control of reactional episodes while employing this combined therapy.

  17. Treatment with Mycophenolat Mofetil of Steroid-Dependent Asthma—One Case of Severe Asthma

    Directory of Open Access Journals (Sweden)

    V. Backer

    2009-01-01

    Full Text Available Background. Some patients with severe nonallergic asthma can be difficult to treat with conventional therapy. Mycophenolat Mofetil (MMF is an immunosuppressive drug with multiple mechanisms. There is theoretical support of specific effect of MMF on severe asthma, in “difficult to treat” patients. The aim of the present case was to explore whether MMF had an effect in one case of severe refractory asthma. The patient. This case deals with one patient with very severe nonallergic treatment refractory asthma who experienced treatment failure on ordinary antiasthmatic treatment and severe adverse events to conventional immunosupressive treatment. She was then treated with MMF. Results. The patient experienced a gain in FEV1 and a reduction in the need for oral glucocorticosteroids as well as seldom need of when needed bronchodilator both during daytime and night. It therefore seems very interesting to examine the use of MMF for severe refractory asthma with further clinical studies and basic cellular trials.

  18. EDTA Dependent Pseudothrombocytopenia In A Patient With Scrub Typhus - A Case Report

    Directory of Open Access Journals (Sweden)

    Bhavya P Mohan

    2016-01-01

    Full Text Available We report a case of EDTA induced pseudothrombocytopenia (EDTA-PTCP in a patient with scrub typhus who was referred as a case of PUO with marked thrombocytopenia and treated with platelet transfusion. Blood smear examination revealed numerous platelet aggregates. CBC analysis using citrate and lithium-heparin as anticoagulants as well as a peculiar WBC histogram aided in prompt diagnosis of the condition. The prevalence of EDTA-PTCP in general hospital population is approximately 0.1%. It is usually not associated with hemorrhagic manifestations. Hence cases of thrombocytopenia should be carefully evaluated to rule out this form of artefactual thrombocytopenia. Timely diagnosis of this innocuous but misleading in vitro phenomenon can save the patient from unnecessary transfusions and invasive procedures.

  19. The path dependency theory: analytical framework to study institutional integration. The case of France

    Science.gov (United States)

    Trouvé, Hélène; Couturier, Yves; Etheridge, Francis; Saint-Jean, Olivier; Somme, Dominique

    2010-01-01

    Background The literature on integration indicates the need for an enhanced theorization of institutional integration. This article proposes path dependence as an analytical framework to study the systems in which integration takes place. Purpose PRISMA proposes a model for integrating health and social care services for older adults. This model was initially tested in Quebec. The PRISMA France study gave us an opportunity to analyze institutional integration in France. Methods A qualitative approach was used. Analyses were based on semi-structured interviews with actors of all levels of decision-making, observations of advisory board meetings, and administrative documents. Results Our analyses revealed the complexity and fragmentation of institutional integration. The path dependency theory, which analyzes the change capacity of institutions by taking into account their historic structures, allows analysis of this situation. The path dependency to the Bismarckian system and the incomplete reforms of gerontological policies generate the coexistence and juxtaposition of institutional systems. In such a context, no institution has sufficient ability to determine gerontology policy and build institutional integration by itself. Conclusion Using path dependence as an analytical framework helps to understand the reasons why institutional integration is critical to organizational and clinical integration, and the complex construction of institutional integration in France. PMID:20689740

  20. On Attributes, Roles, and Dependencies in Description Logics and the Ackermann Case of the Decision Problem

    DEFF Research Database (Denmark)

    Toman, David; Weddel, Grant Edwin

    2001-01-01

    We present a decision procedure for the logical implication problem of a boolean complete DL dialect that includes attributes roles inverse roles and a new concept constructor that is capable of expressing a variety of equality and order generating dependencies The procedure underlies a mapping...

  1. Mitigating the Risk of Extreme Water Scarcity and Dependency: The Case of Jordan

    Directory of Open Access Journals (Sweden)

    Joep F. Schyns

    2015-10-01

    Full Text Available Jordan faces great internal water scarcity and pollution, conflict over trans-boundary waters, and strong dependency on external water resources through trade. This paper analyzes these issues and subsequently reviews options to reduce the risk of extreme water scarcity and dependency. Based on estimates of water footprint, water availability, and virtual water trade, we find that groundwater consumption is nearly double the groundwater availability, water pollution aggravates blue water scarcity, and Jordan’s external virtual water import dependency is 86%. The review of response options yields 10 ingredients for a strategy for Jordan to mitigate the risks of extreme water scarcity and dependency. With respect to these ingredients, Jordan’s current water policy requires a strong redirection towards water demand management. Actual implementation of the plans in the national water strategy (against existing oppositions would be a first step. However, more attention should be paid to reducing water demand by changing the consumption pattern of Jordanian consumers. Moreover, unsustainable exploitation of the fossil Disi aquifer should soon be halted and planned desalination projects require careful consideration regarding the sustainability of their energy supply.

  2. Unilateral Dependant Pulmonary Edema During Laparoscopic Donor Nephrectomy: Report of Three Cases

    Directory of Open Access Journals (Sweden)

    Manisha Modi

    2009-01-01

    Full Text Available Unilateral pulmonary edema of the dependant lung was observed in three patients during laparoscopic donor nephrectomy. Patients were treated with 02 supplementation by face mask, fluid restriction and diuretic. All the patients were relieved of symptoms with radiological improvement. The possible causes of this unusual complication following laparoscopic surgery appear to be prolonged lateral decubitus position and high intraoperative fluid infusion.

  3. On the Content-Dependence of Prospective Teachers' Knowledge: A Case of Exemplifying Definitions

    Science.gov (United States)

    Leikin, Roza; Zazkis, Rina

    2010-01-01

    In this article, we demonstrate that prospective teachers' content knowledge related to defining mathematical concepts is dependent on content area. We use the example of generation (a research tool we developed in a previous study) to investigate prospective teachers' knowledge. We asked prospective secondary mathematics teachers to provide…

  4. From Teacher Dependence to Learner Independence: Case Study from the Dubai Women's College.

    Science.gov (United States)

    Hawker, Laila

    The process of shifting from the educational practice paradigm of the traditional teacher-dependent classroom to an independent learning environment requires transformation of attitudes, beliefs, and actions of students and teachers alike through understanding and acquisition and application of fundamental learning principles, skills, and…

  5. The path dependency theory: analytical framework to study institutional integration. The case of France

    Directory of Open Access Journals (Sweden)

    Hélène Trouvé

    2010-06-01

    Full Text Available Background: The literature on integration indicates the need for an enhanced theorization of institutional integration. This article proposes path dependence as an analytical framework to study the systems in which integration takes place.Purpose: PRISMA proposes a model for integrating health and social care services for older adults. This model was initially tested in Quebec. The PRISMA France study gave us an opportunity to analyze institutional integration in France.Methods: A qualitative approach was used. Analyses were based on semi-structured interviews with actors of all levels of decision-making, observations of advisory board meetings, and administrative documents.Results: Our analyses revealed the complexity and fragmentation of institutional integration. The path dependency theory, which analyzes the change capacity of institutions by taking into account their historic structures, allows analysis of this situation. The path dependency to the Bismarckian system and the incomplete reforms of gerontological policies generate the coexistence and juxtaposition of institutional systems. In such a context, no institution has sufficient ability to determine gerontology policy and build institutional integration by itself.Conclusion: Using path dependence as an analytical framework helps to understand the reasons why institutional integration is critical to organizational and clinical integration, and the complex construction of institutional integration in France.

  6. The path dependency theory: analytical framework to study institutional integration. The case of France

    Directory of Open Access Journals (Sweden)

    Hélène Trouvé

    2010-06-01

    Full Text Available Background: The literature on integration indicates the need for an enhanced theorization of institutional integration. This article proposes path dependence as an analytical framework to study the systems in which integration takes place. Purpose: PRISMA proposes a model for integrating health and social care services for older adults. This model was initially tested in Quebec. The PRISMA France study gave us an opportunity to analyze institutional integration in France. Methods: A qualitative approach was used. Analyses were based on semi-structured interviews with actors of all levels of decision-making, observations of advisory board meetings, and administrative documents. Results: Our analyses revealed the complexity and fragmentation of institutional integration. The path dependency theory, which analyzes the change capacity of institutions by taking into account their historic structures, allows analysis of this situation. The path dependency to the Bismarckian system and the incomplete reforms of gerontological policies generate the coexistence and juxtaposition of institutional systems. In such a context, no institution has sufficient ability to determine gerontology policy and build institutional integration by itself. Conclusion: Using path dependence as an analytical framework helps to understand the reasons why institutional integration is critical to organizational and clinical integration, and the complex construction of institutional integration in France.

  7. The Bloch wave operator: generalizations and applications: II. The time-dependent case

    Energy Technology Data Exchange (ETDEWEB)

    Jolicard, Georges [Observatoire de Besancon (UMR-CNRS 6091), Universite de Franche-Comte, 41 bis, Avenue de l' Observatoire, 25000 Besancon (France); Killingbeck, John P [Observatoire de Besancon (UMR-CNRS 6091), Universite de Franche-Comte, 41 bis, Avenue de l' Observatoire, 25000 Besancon (France); Mathematics Department, University of Hull, Hull HU6 7RX (United Kingdom)

    2003-10-10

    Part II of the review shows how the stationary Bloch wave operator of part I can be suitably modified to give a time-dependent wave operator. This operator makes it possible to use a relatively small active space in order to describe the dynamical processes which occur in quantum mechanical systems which have a time-dependent Hamiltonian. A close study is made of the links between the time-dependent and time-independent wave operators at the adiabatic limit; the analysis clarifies the way in which the wave operator formalism allows the time evolution of a system or a wave packet to be described in terms of a fast evolution inside the active space together with weak transitions out of this space which can be treated by perturbation methods. Two alternative wave operator equations of motion are derived and analysed. The first one is a non-linear differential equation in the usual Hilbert space; the second one is a differential equation in an extended Hilbert space with an extra time variable added and becomes equivalent to the usual Bloch equation when the Floquet Hamiltonian is taken in place of the ordinary Hamiltonian. A study is made of the close relationships between the time-dependent wave operator formalism, the Floquet theory and the (t, t') theory. Some original methods of solution of the two forms of wave operator equation are proposed and lead to new techniques of integration for the time-dependent Schroedinger equation (e.g., the generalized Green equation procedure). Mixed procedures involving both the time-independent and time-dependent wave operators are shown to be applicable to the internal eigenstate problem for large complex matrices. A detailed account is given of the description of inelastic and photoreactive processes by means of the time-dependent wave operator formalism, with particular attention to laser-molecule interactions. The emphasis is on projection operator techniques, with special attention being given to the method of selection

  8. CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study.

    Science.gov (United States)

    Luo, Xingguang; Kranzler, Henry R; Zuo, Lingjun; Wang, Shuang; Blumberg, Hilary P; Gelernter, Joel

    2005-08-15

    Cholinergic muscarinic 2 receptor (CHRM2) is implicated in memory and cognition, functions impaired in many neuropsychiatric disorders. Wang et al. [Wang, J.C., Hinrichs, A.L., Stock, H., Budde, J., Allen, R., Bertelsen, S., Kwon, J.M., Wu, W., Dick, D.M., Rice, J. et al. (2004) Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome. Hum. Mol. Genet., 13, 1903-1911] reported that variation in CHRM2 gene predisposed to alcohol dependence (AD) and major depressive syndrome. We examined the relationships between variation in CHRM2 and AD, drug dependence (DD) and affective disorders, using a novel extended case-control structured association (SA) method. Six markers at CHRM2 and 38 ancestry-informative markers (AIMs) were genotyped in a sample of 871 subjects, including 333 healthy controls [287 European-Americans (EAs) and 46 African-Americans (AAs)] and 538 AD and/or DD subjects (415 with AD and 346 with DD and 382 EAs and 156 AAs). The same CHRM2 markers were genotyped in a sample of 137 EA subjects with affective disorders. All of the six markers were in Hardy-Weinberg equilibrium in controls, but SNP3 (rs1824024) was in Hardy-Weinberg disequilibrium in the AD and DD groups. Using conventional case-control comparisons, some markers were nominally significantly or suggestively associated with phenotypes before or after controlling for population stratification and admixture effects, but these associations were not significant after multiple test correction. However, regression analysis identified specific alleles, genotypes, haplotypes and diplotypes that were significantly associated with risk for each disorder. We conclude that variation in CHRM2 predisposes to AD, DD and affective disorders. One haplotype block within the 5'-UTR of CHRM2 may be more important for the development of these disorders than other regions. Interaction between two

  9. Assessment of the status, development and diversification of fisheries-dependent communities: Urk Case Study Report

    NARCIS (Netherlands)

    Delaney, A.E.; Hoefnagel, E.W.J.; Bartelings, H.; Oosterhout, van J.

    2010-01-01

    This case study about Urk shows which social and economic challenges this traditional fishing community faces due to its specialization on just a few stocks, the increasing independence of a processing sector no longer reliant on it to supply locally caught fish, and culturally preferences in the

  10. Object-oriented Bayesian networks for paternity cases with allelic dependencies

    Science.gov (United States)

    Hepler, Amanda B.; Weir, Bruce S.

    2008-01-01

    This study extends the current use of Bayesian networks by incorporating the effects of allelic dependencies in paternity calculations. The use of object-oriented networks greatly simplify the process of building and interpreting forensic identification models, allowing researchers to solve new, more complex problems. We explore two paternity examples: the most common scenario where DNA evidence is available from the alleged father, the mother and the child; a more complex casewhere DNA is not available from the alleged father, but is available from the alleged father’s brother. Object-oriented networks are built, using HUGIN, for each example which incorporate the effects of allelic dependence caused by evolutionary relatedness. PMID:19079769

  11. Testing the Environmental Dependence of the Stellar Initial Mass Function - the Case of L1641

    Science.gov (United States)

    Hsu, Wen-hsin; Hartmann, L.; Allen, L.; Hernandez, J.; Megeath, T.

    2012-01-01

    To test the proposition that the stellar initial mass function (IMF) depends on the environmental density, we conducted an optical spectroscopic and photometric survey of the young stellar population in L1641, a low-density, star-forming region of the Orion A cloud south of the dense Orion Nebula Cluster (ONC). We used low-resolution optical spectra and optical photometry, as well as the Spitzer IRAC photometry (Megeath et al. 2011) to identify members and obtain spectral types. As of now, we have confirmed and spectral-typed 648 members and project a total number of 780 members with moderate extinction. Our study suggests a comparison between L1641 and the ONC can yield a statistically-significant test of the dependence of the upper mass portion of the stellar initial mass function upon environment. Our preliminary results indicate that L1641 may well be deficient in O and early B stars.

  12. Pyridoxine Dependent Seizures-Report Of A Case And Brief Review Of Literature

    Directory of Open Access Journals (Sweden)

    Rajesh R

    2002-01-01

    Full Text Available Pyridoxine-dependent seizure is a rare autosornal recessive disorder that usually presents as neonatal intractable seizures. This syndrome is due to an inborn abnormality of the enzyme glutamic acid decarboxylase, which results in reduced pyridoxine-dependent synthesis of the inhibitory neurotransmitter gamma amino butyric acid. We report a girl child who had seizures on the second post natal day which was controlled with oral pyridoxine. She had status epilepticus twice when the drug was stopped at the age of 3 months and 21 months. The neurological development was normal. There was normalization of EEG abnormalities on intravenous administration of 100 mg pyridoxine. A brief review of the literature is also included.

  13. Poorer Prognosis With Ethylenediaminetetraacetic Acid-dependent Pseudothrombocytopenia: A Single-center Case-control Study.

    OpenAIRE

    2015-01-01

    Abstract In ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia (PTCP), automated platelet counts are lower than actual counts because of EDTA-induced aggregation. Factors contributing to the incidence of EDTA-PTCP are unknown, and no study has assessed the prognosis of EDTA-PTCP patients. This retrospective study assessed characteristics in EDTA-PTCP patients and matched controls to determine differences in prognosis. A retrospective case–control study was designed. From ...

  14. The Effects of Dependency on Debt Financing On Financial Reporting Policy: The Case of Greece

    OpenAIRE

    Athanasios P. Bellas; Christos Tzovas

    2008-01-01

    Financial statements information is supposed to influence the credit decisions of credit institutions. Furthermore, debt agreements include terms based upon accounting numbers. Within this context an accounting choice aiming to minimize tax liability might generate significant non-tax costs for a firm. The significance of these costs is conditioned upon the level of dependency of firm on debt financing. This paper examines the arguments that have been developed regarding the association betwe...

  15. A variation iteration method for isotropic velocity-dependent potentials: Scattering case

    Energy Technology Data Exchange (ETDEWEB)

    Eed, H. [Applied Science Private University, Basic Science Department, Amman (Jordan)

    2014-12-01

    We propose a new approximation scheme to obtain analytic expressions for the Schroedinger equation with isotropic velocity-dependent potential to determine the scattering phase shift. In order to test the validity of our approach, we applied it to an exactly solvable model for nucleon-nucleon scattering. The results of the variation iteration method (VIM) formalism compare quite well with those of the exactly solvable model. The developed formalism can be applied in problems concerning pion-nucleon, nucleon-nucleon, and electron-atom scattering. (orig.)

  16. Mind the gap – context dependency in invasive species impacts: a case study of the ascidian Ciona robusta

    Directory of Open Access Journals (Sweden)

    Tamara B. Robinson

    2017-01-01

    Full Text Available In the face of increasing invasions and limited resources, appropriate management of invasive species requires prioritisation of species for management action. This process often relies on knowledge of species specific impacts. However, as studies explicitly measuring impact of marine alien species are rare, prioritisation of management actions is often based on studies from outside the geographic area of interest. Further, few impact studies account for context dependency (e.g. seasonal variability or distinct environmental regimes, raising the question of how transferrable knowledge about the impact of a species is between invaded ranges. This study addressed this question by using the widespread invasive solitary ascidian Ciona robusta as a case study for assessing impacts across two invaded regions: South Africa and California, USA. We replicated a previously conducted experiment from California that showed that C. robusta depresses local species richness in San Francisco Bay. Our South African experiment showed no effect of C. robusta on species richness, the Shannon-Weiner diversity index or community composition, despite experiments being carried out over two years and at two depths. While these results may reflect strong density dependency in the impact of C. robusta, they serve to highlight context dependency in invasive species impacts. This suggests that until studies of impact in marine systems become common place, context dependency should be explicitly addressed as a source of uncertainty during the prioritisation of species for management action.

  17. Case report: Is verbal cognitive performance in bilingual neuropsychiatric patients test-language dependent?

    Science.gov (United States)

    Rodriguez, Mabel; Kratochvilova, Zuzana; Kuniss, Renata; Vorackova, Veronika; Dorazilova, Aneta; Fajnerova, Iveta

    2015-12-01

    Bilingualism (BL) is increasing around the world. Although BL has been shown to have a broad impact-both positive and negative-on language and cognitive functioning, cognitive models and standards are mainly based on monolinguals. If we take cognitive performance of monolinguals as a standard, then the performance of bilinguals might not be accurately estimated. The assessment of cognitive functions is an important part of both the diagnostic process and further treatment in neurological and neuropsychiatric patients. In order to identify the presence or absence of cognitive deficit in bilingual patients, it will be important to determine the positive and/or negative impact of BL properties on measured cognitive performance. However, research of the impact of BL on cognitive performance in neuropsychiatric patients is limited. This article aims to compare the influence of the language (dominant-L1, second-L2) used for assessment of verbal cognitive performance in two cases of bilingual neuropsychiatric patients (English/Czech). Despite the fact that the two cases have different diagnoses, similarities in working memory and verbal learning profiles for L1 and L2 were present in both patients. We expected L1 to have higher performance in all measures when compared with L2. This assumption was partially confirmed. As expected, verbal working memory performance was better when assessed in L1. In contrast, verbal learning showed the same or better performance in L2 when compared with L1. Verbal fluency and immediate recall results were comparable in both languages. In conclusion, the language of administration partially influenced verbal performance of bilingual patients. Whether the language itself influenced low performance in a given language or it was a result of a deficit requires further research. According to our results, we suggest that an assessment in both languages needs to be a component of reasonable cognitive assessment of bilingual patients.

  18. The use of very high-doses of baclofen for the treatment of alcohol-dependence: a case series.

    Directory of Open Access Journals (Sweden)

    Renaud ede Beaurepaire

    2014-10-01

    Full Text Available Baclofen, particularly high-dose baclofen, has recently emerged as a treatment of major interest for alcohol-dependence. However, baclofen has many potentially dangerous side effects, and the maximal dose of baclofen that may be used is a matter of discussion. Here, the author analyses the medical charts of the last 100 patients seen in his clinic, 17 of whom have been taking a very high dose of baclofen, that is to say, more than 300mg per day. The analysis of the charts shows that the very high doses baclofen were justified in almost all the cases. Side effects are analyzed.

  19. Groundwater dependence of coastal lagoons: The case of La Pletera salt marshes (NE Catalonia)

    Science.gov (United States)

    Menció, A.; Casamitjana, X.; Mas-Pla, J.; Coll, N.; Compte, J.; Martinoy, M.; Pascual, J.; Quintana, X. D.

    2017-09-01

    Coastal wetlands are among the most productive ecosystems of the world, playing an important role in coastal defense and wildlife conservation. These ecosystems, however, are usually affected by human activities, which may cause a loss and degradation of their ecological status, a decline of their biodiversity, an alteration of their ecological functioning, and a limitation of their ecosystem services. La Pletera salt marshes (NE Spain) are located in a region mainly dominated by agriculture and tourism activities. Part of these wetlands and lagoons has been affected by an incomplete construction of an urban development and in this moment is the focus of a Life+ project, whose aim is to restore this protected area. Several studies have analyzed the role of hydrological regime in nutrients, phytoplankton and zooplankton in this area, however, the role of groundwater was never considered as a relevant factor in the lagoon dynamics, and its influence is still unknown. In this study, the hydrogeological dynamics in La Pletera salt marshes has been analyzed, as a basis to set sustainable management guidelines for this area. In order to determine their dependence on groundwater resources, monthly hydrochemical (with major ions and nutrients) and isotopic (δ18OH2O and δD) campaigns have been conducted, from November 2014 to October 2015. In particular, groundwater from six wells, surface water from two nearby streams and three permanent lagoons, and sea water was considered in these surveys. Taking into account the meteorological data and the water levels in the lagoons, the General Lake Model has been conducted to determine, not only evaporation and rainfall occurring in the lagoons, but also the total inflows and outflows. In addition, the Gonfiantini isotopic model, together with equilibrium chemical-speciation/mass transfer models, has been used to analyze the evaporation and the physicochemical processes affecting the lagoons. Results show that during the dry

  20. From import dependency to export orientation the case of the chilean dairy sector

    Directory of Open Access Journals (Sweden)

    Paulina Rytkönen

    2011-12-01

    replaced by a highly liberalized process paved the way for breaking import dependency. Strategic decisions by the industry resulted in long term improved competitive power and a final shift towards exports. Contrary to previous research, this article shows that globalization is the main force behind the reorientation of the dairy sector in Chile from import dependency to export orientation.

  1. Prejuízos neurocognitivos na dependência alcoólica: um estudo de caso Neurocognitive impairments in alcohol dependence: a case report

    Directory of Open Access Journals (Sweden)

    Rosa Maria Tedeschi Vieira

    2007-01-01

    Full Text Available CONTEXTO: A alta prevalência de indivíduos dependentes de álcool estimula a realização de estudos que ampliem o entendimento de seus efeitos sobre o organismo. OBJETIVO: O objetivo deste estudo foi avaliar a preservação e prejuí­zo de funções neuropsicológicas em um caso de dependência alcoólica. Trata-se de estudo de caso de um alcoolista em tratamento medicamentoso no Hospital das Clínicas da Universidade de São Paulo, que declarava encontrar-se abstêmio desde o início do tratamento há cerca de um ano. MÉTODOS: Os instrumentos utilizados neste estudo foram entrevistas e testes neuropsicológicos (WAIS-III, Figura de Rey e WRAML-II. RESULTADOS: Os resultados das funções visuomotoras, praxia construtiva, memórias visual e verbal e capacidade de aprendizagem apresentaram graves prejuízos. O paciente teve um desempenho ligeiramente melhor, embora ainda rebaixado, em linguagem, aritmética e memória para sentenças curtas. A atenção imediata teve resultado dentro da normalidade, dado consistente com achados anteriores. O resultado no Subteste Semelhanças reforça evidências da capacidade de generalização em indivíduos dependentes de álcool. CONCLUSÃO: Conclui-se que os dados obtidos são consistentes com a literatura atual que apontam graves prejuízos na memória e funções visuomotoras paralelamente a manutenção da atenção e capacidade de generalização.BACKGROUND: The high prevalence of alcohol dependence asks for a better comprehension of its effects on the organism. OBJECTIVE: The aim of this study was to evaluate prejudice and preservation of neuropsychological functions of alcohol dependence. It is presented a case report of a patient under drug treatment in Hospital das Clínicas da Universidade de São Paulo. The patient declared abstinence since the beginning of the treatment, about one year ago. METHODS: Interviews and neuropsycological tests (WAIS-III, Figure of Rey and WRAML-II. RESULTS: The

  2. Alcohol Dependence Associated with Increased Utilitarian Moral Judgment: A Case Control Study

    Science.gov (United States)

    Khemiri, Lotfi; Guterstam, Joar; Franck, Johan; Jayaram-Lindström, Nitya

    2012-01-01

    Recent studies indicate that emotional processes, mediated by the ventromedial prefrontal cortex (VMPC), are of great importance for moral judgment. Neurological patients with VMPC dysfunction have been shown to generate increased utilitarian moral judgments, i.e. are more likely to endorse emotionally aversive actions in order to maximize aggregate welfare, when faced with emotionally salient personal moral dilemmas. Patients with alcohol dependence (AD) also exhibit impairments in functions mediated by the prefrontal cortex, but whether they exhibit increased utilitarian moral reasoning has not previously been investigated. The aim of this study was to investigate moral judgment in AD patients (n = 20) compared to healthy controls (n = 20) matched by sex, age and education years. Each subject responded to a battery of 50 hypothetical dilemmas categorized as non-moral, moral impersonal and moral personal. They also responded to a questionnaire evaluating explicit knowledge of social and moral norms. Results confirmed our hypothesis that AD patients generated increased utilitarian moral judgment compared to controls when faced with moral personal dilemmas. Crucially, there was no difference in their responses to non-moral or impersonal moral dilemmas, nor knowledge of explicit social and moral norms. One possible explanation is that damage to the VMPC, caused by long term repeated exposure to alcohol results in emotional dysfunction, predisposing to utilitarian moral judgment. This work elucidates a novel aspect of the neuropsychological profile of AD patients, namely a tendency to generate utilitarian moral judgment when faced with emotionally salient moral personal dilemmas. PMID:22761922

  3. Modeling Changing Morphology and Density Dependent Groundwater Flow in a Dynamic Environment: case study

    Science.gov (United States)

    Huizer, Sebastian; Bierkens, Marc; Oude Essink, Gualbert

    2015-04-01

    The prospect of sea level rise and increase in extreme weather conditions has led to a new focus on coastal defense in the Netherlands. As an innovative solution for coastal erosion a mega-nourishment named the Sand Motor (or Sand Engine) has been constructed at the Dutch coast. This body of sand will be distributed slowly along the coastline by wind, waves and currents; keeping the coastal defense structures in place and creating a unique, dynamic environment with changing morphology over time. The large size and position of the Sand Motor might lead to a substantial increase of fresh ground water resources. This creates an opportunity to combine coastal protection with an increase of fresh water resources in coastal regions. With a three dimensional, density dependent, groundwater model the effects of changing morphology over time and the potential increase in fresh water availability have been studied. The preliminary model calculations show that in a period of 20 years volume of fresh water gradually increases to ca. 12 Mm3. In the nearby dune area 7-8 Mm3 is abstracted yearly, therefore the first results are promising in increasing fresh groundwater resources. More model calculations will be performed to investigate the sensitivity of the change in the fresh, brackish and salt water distribution.

  4. Modeling Changing Morphology and Density Dependent Groundwater Flow in a Dynamic Environment: case study

    Science.gov (United States)

    Huizer, S.; Bierkens, M. F.; Oude Essink, G.

    2014-12-01

    In many coastal regions around the world climate change will lead to a sea level rise and an increase in extreme weather conditions. This prospect has resulted in a new focus on coastal protection in the Netherlands, resulting in the initiation of an innovative coastal defence project called the Sand Motor. In this project a large body of sand or so-called mega-nourishment has been constructed along the Dutch coast. This body of sand will be distributed slowly along the coastline by wind, waves and currents. Keeping the coastal defence structures in place and creating a unique, dynamic environment with changing morphology over time. Because of the large size of the body of sand (21.5 million m3) and the position at the coastline and near coastal dunes, the Sand Motor might cause a substantial increase of the fresh water availability by increasing the volume fresh water lens underneath the dunes. This creates an opportunity to combine coastal protection with an increase of fresh water resources in coastal regions. With a three dimensional, density dependent, groundwater model the effects of changing morphology over time and the potential increase in fresh water availability have been studied.

  5. Delineating species with DNA barcodes: a case of taxon dependent method performance in moths.

    Directory of Open Access Journals (Sweden)

    Mari Kekkonen

    Full Text Available The accelerating loss of biodiversity has created a need for more effective ways to discover species. Novel algorithmic approaches for analyzing sequence data combined with rapidly expanding DNA barcode libraries provide a potential solution. While several analytical methods are available for the delineation of operational taxonomic units (OTUs, few studies have compared their performance. This study compares the performance of one morphology-based and four DNA-based (BIN, parsimony networks, ABGD, GMYC methods on two groups of gelechioid moths. It examines 92 species of Finnish Gelechiinae and 103 species of Australian Elachistinae which were delineated by traditional taxonomy. The results reveal a striking difference in performance between the two taxa with all four DNA-based methods. OTU counts in the Elachistinae showed a wider range and a relatively low (ca. 65% OTU match with reference species while OTU counts were more congruent and performance was higher (ca. 90% in the Gelechiinae. Performance rose when only monophyletic species were compared, but the taxon-dependence remained. None of the DNA-based methods produced a correct match with non-monophyletic species, but singletons were handled well. A simulated test of morphospecies-grouping performed very poorly in revealing taxon diversity in these small, dull-colored moths. Despite the strong performance of analyses based on DNA barcodes, species delineated using single-locus mtDNA data are best viewed as OTUs that require validation by subsequent integrative taxonomic work.

  6. Estimating the impacts of fishing on dependent predators: a case study in the California Current.

    Science.gov (United States)

    Field, J C; MacCall, A D; Bradley, R W; Sydeman, W J

    2010-12-01

    Juvenile rockfish (Sebastes spp.) are important prey to seabirds in the California Current System, particularly during the breeding season. Both seabird breeding success and the abundance of pelagic juvenile rockfish show high interannual variability. This covariation is largely a response to variable ocean conditions; however, fishing on adult rockfish may have had consequences for seabird productivity (e.g., the number of chicks fledged per breeding pair) by reducing the availability of juvenile rockfish to provisioning seabird parents. We tested the hypothesis that fishing has decreased juvenile rockfish availability and thereby limited seabird productivity over the past 30 years. We quantified relationships between observed juvenile rockfish relative abundance and seabird productivity, used fisheries stock assessment approaches to estimate the relative abundance of juvenile rockfish in the absence of fishing, and compared the differences in seabird productivity that would have resulted without rockfish fisheries. We examined the abundance of juvenile rockfish and the corresponding productivity of three seabird species breeding on Southeast Farallon Island (near San Francisco, California, USA) from the early 1980s to the present. Results show that while the relative abundance of juvenile rockfish has declined to approximately 50% of the estimated unfished biomass, seabirds achieved 75-95% of the estimated un-impacted levels of productivity, depending upon the species of bird and various model assumptions. These results primarily reflect seabirds with "conservative" life histories (one egg laid per year) and may be different for species with more flexible life history strategies (greater reproductive effort). Our results are consistent with the premise that the impacts of local rockfish fisheries on seabird productivity are less than impacts that have occurred to the prey resources themselves due to ocean climate and the ability of seabirds to buffer against

  7. Does Innovation Performance Depend on Economic Growth?: The Case of a Country in Transition

    Directory of Open Access Journals (Sweden)

    Andrzej H Jasinski

    2011-12-01

    Full Text Available This paper is an attempt to analyze a possible influence of economic growth on innovation performance. Econometric model based on principal component analysis is the research tool. Poland, as a country in transition, is here a case-study. The analysis has confirmed an interesting pattern: in 1989-2007, corporate innovation performance was changing, in principle, in the same direction as macro-economic changes but with a one-to-two-year delay. This is some proof that the innovation activity followed the cyclical development of the national economy. Innovation performance was demand-driven, i.e., pulled by demand resulting from the economy's recovery and high economic growth. So, technological innovation appeared to be highly sensitive to the general economic situation in Poland as a transitional economy. Economic growth seems to be a kind of tag-boat pulling innovation activities in the business sector.Este artículo intenta analizar una posible influencia del crecimiento económico en el desempeño de la innovación. La herramienta de investigación empleada es el modelo econométrico basado en un componente principal de análisis. El estudio de caso es Polonia, una economía en transición. El análisis ha confirmado un patrón interesante: durante el periodo 1989-2007, el desempeño de la innovación cambió, en principio, en la misma dirección que los cambios macroeconómicos pero con un retraso de uno a dos años. Esto muestra de algún modo que la actividad innovadora correspondió al desarrollo cíclico de la economía nacional. El desempeño innovador se orientó por la demanda, es decir, una demanda impulsada por la recuperación económica y el alto crecimiento económico. Por lo tanto, la innovación tecnológica parece ser muy sensible a la situación económica en general de Polonia, como economía en transición. El crecimiento económico parece ser una especie de motor que impulsa las actividades innovadoras del sector de negocios.

  8. Phase-Angle Dependence of Determinations of Diameter, Albedo, and Taxonomy: A Case Study of NEO 3691 Bede

    Science.gov (United States)

    Wooden, Diane H.; Lederer, Susan M.; Jehin, Emmanuel; Howell, Ellen S.; Fernandez, Yan; Harker, David E.; Ryan, Erin; Lovell, Amy; Woodward, Charles E.; Benner, Lance A.

    2015-01-01

    Parameters important for NEO risk assessment and mitigation include Near-Earth Object diameter and taxonomic classification, which translates to surface composition. Diameters of NEOs are derived from the thermal fluxes measured by WISE, NEOWISE, Spitzer Warm Mission and ground-based telescopes including the IRTF and UKIRT. Diameter and its coupled parameters Albedo and IR beaming parameter (a proxy for thermal inertia and/or surface roughness) are dependent upon the phase angle, which is the Sun-target-observer angle. Orbit geometries of NEOs, however, typically provide for observations at phase angles greater than 20 degrees. At higher phase angles, the observed thermal emission is sampling both the day and night sides of the NEO. We compare thermal models for NEOs that exclude (NEATM) and include (NESTM) night-side emission. We present a case study of NEO 3691 Bede, which is a higher albedo object, X (Ec) or Cgh taxonomy, to highlight the range of H magnitudes for this object (depending on the albedo and phase function slope parameter G), and to examine at different phase angles the taxonomy and thermal model fits for this NEO. Observations of 3691 Bede include our observations with IRTF+SpeX and with the 10 micrometer UKIRT+Michelle instrument, as well as WISE and Spitzer Warm mission data. By examining 3691 Bede as a case study, we highlight the interplay between the derivation of basic physical parameters and observing geometry, and we discuss the uncertainties in H magnitude, taxonomy assignment amongst the X-class (P, M, E), and diameter determinations. Systematic dependencies in the derivation of basic characterization parameters of H-magnitude, diameter, albedo and taxonomy with observing geometry are important to understand. These basic characterization parameters affect the statistical assessments of the NEO population, which in turn, affects the assignment of statistically-assessed basic parameters to discovered but yet-to-be-fully-characterized NEOs.

  9. Long-term misuse of zopiclone in an alcohol dependent woman with a history of anorexia nervosa: a case report

    Directory of Open Access Journals (Sweden)

    Keaney Francis

    2010-12-01

    Full Text Available Abstract Introduction The Z-drugs, zaleplon, zopiclone and zolpidem, are short-acting hypnotics which act at the same receptor as the benzodiazepines, but seemingly without the potential for misuse and the development of dependence of the older benzodiazepines. However, with increased prescribing of Z-drugs, reports of misuse and possible dependence began to appear in the literature, particularly in people with a history of substance misuse and comorbid psychiatric illness. Here we report the case of a woman with a history of chronic zopiclone use and anorexia nervosa, admitted for alcohol detoxification. Case presentation A 31-year old Caucasian British woman with a history of long-term zopiclone use and anorexia nervosa was admitted as an inpatient for a ten-day alcohol detoxification. Her weekly (four days out of seven intake of alcohol was 180 units and her daily intake of zopiclone, 30 mg. Apart from a short period five years ago, she had been taking zopiclone for 13 years at daily doses of up to 90 mg. She admitted to using 'on top' of her prescribed medication, purchasing extra tablets from friends or receiving them gratis from her partner. After detoxification from alcohol and zopiclone, she was prescribed diazepam which she found ineffectual and voiced her intention of returning to zopiclone on leaving the hospital. Conclusion Zopiclone is generally regarded as safer than benzodiazepines, however, this particular individual, who was using high doses of zopiclone over many years, may provide further evidence of a risk of dependency when this drug is prescribed for substance users with a comorbid psychiatric illness.

  10. EDTA-dependent pseudothrombocytopenia: a clinical and epidemiological study of 112 cases, with 10-year follow-up.

    Science.gov (United States)

    Bizzaro, N

    1995-10-01

    In the past 10 years, we have observed 112 cases of EDTA-dependent pseudothrombocytopenia (PTCP) due to in vitro platelet clumping at room temperature. 93 patients had antiplatelet antibodies (48 IgM, 30 IgG, 3 IgA, and 12 had two different isotypes concomitantly). In 20% of patients, the presence of IgM antibodies characteristically accompanied platelet agglutination also at 37 degrees C, and in citrated blood. The phenomenon was not age or sex related, nor was it associated with any particular pathology or use of specific drugs, and was present in both healthy subjects and patients with various diseases. Flow cytofluorimetric analysis of CD5-positive B cells, which are responsible for autoantibody production, did not demonstrate any changes in the percentage and absolute number of this lymphocyte subset. Average follow-up was 5 years (6 months-10 years); however, previous clinical records disclosed that PTCP was present for more than 15 years in four cases, and more than 20 years in three others, with no clinical manifestation of disease. This study confirms that EDTA-dependent PTCP is a phenomenon related to the presence of natural autoantibodies with antiplatelet activity, devoid of pathological significance. Its clinical interest resides in the need for its prompt and certain recognition in order to avoid unnecessary examinations and therapeutic interventions. The best and most rapid technique for obtaining accurate platelet counts in PTCP subjects is to collect and examine EDTA blood at 37 degrees C; however, clumping will still be present in about 20% of these cases, and even in citrated blood. To obviate this phenomenon, blood should be collected in ammonium oxalate, and platelets counted in a Burker chamber.

  11. First cases of pyridoxine-dependent epilepsy in Bulgaria: novel mutation in the ALDH7A1 gene.

    Science.gov (United States)

    Tincheva, Savina; Todorov, Tihomir; Todorova, Albena; Georgieva, Ralica; Stamatov, Dimitar; Yordanova, Iglika; Kadiyska, Tanya; Georgieva, Bilyana; Bojidarova, Maria; Tacheva, Genoveva; Litvinenko, Ivan; Mitev, Vanyo

    2015-12-01

    Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive disorder characterized by intractable seizures in neonates and infants. The seizures cannot be controlled with antiepileptic medications but respond both clinically and electrographically to large daily supplements of pyridoxine (vitamin B6). PDE is caused by mutations in the ALDH7A1 gene. Molecular genetic analysis of the ALDH7A1 gene was performed in seven patients, referred with clinical diagnosis of PDE. Mutations were detected in a dizygotic twin pair and a non-related boy with classical form of PDE. Direct sequencing of the ALDH7A1 gene revealed one novel (c.297delG, p.Trp99*) and two already reported (c.328C>T, p.Arg110*; c.584A>G, p.Asn195Ser) mutations. Here, we report the first genetically proven cases of PDE in Bulgaria.

  12. Evaluating the governance model of hardware-dependent software ecosystems - a case study of the axis ecosystem

    DEFF Research Database (Denmark)

    Wnuk, Krzysztof; Manikas, Konstantinos; Runeson, Per

    2014-01-01

    specifically, we evaluate the governance model applied by Axis, a network video and surveillance camera producer, that is the platform owner and orchestrator of the Application Development Partner (ADP) software ecosystem. We conduct an exploratory case study collecting data from observations and interviews......Ecosystem governance becomes gradually more relevant for a set of companies or actors characterized by symbiotic relations evolved on the top of a technological platform, i.e. a software ecosystem. In this study, we focus on the governance of a hardware-dependent software ecosystem. More...... and apply the governance model for prevention and improvement of the software ecosystem health proposed by Jansen and Cusumano. Our results reveal that although the governance actions do not address the majority of their governance model, the ADP ecosystem is considered a growing ecosystem providing...

  13. Cerebral misery perfusion diagnosed using hypercapnic blood-oxygenation-level-dependent contrast functional magnetic resonance imaging: a case report

    Directory of Open Access Journals (Sweden)

    D'Souza Olympio

    2010-02-01

    Full Text Available Abstract Introduction Cerebral misery perfusion represents a failure of cerebral autoregulation. It is an important differential diagnosis in post-stroke patients presenting with collapses in the presence of haemodynamically significant cerebrovascular stenosis. This is particularly the case when cortical or internal watershed infarcts are present. When this condition occurs, further investigation should be done immediately. Case presentation A 50-year-old Caucasian man presented with a stroke secondary to complete occlusion of his left internal carotid artery. He went on to suffer recurrent seizures. Neuroimaging demonstrated numerous new watershed-territory cerebral infarcts. No source of arterial thromboembolism was demonstrable. Hypercapnic blood-oxygenation-level-dependent-contrast functional magnetic resonance imaging was used to measure his cerebrovascular reserve capacity. The findings were suggestive of cerebral misery perfusion. Conclusions Blood-oxygenation-level-dependent-contrast functional magnetic resonance imaging allows the inference of cerebral misery perfusion. This procedure is cheaper and more readily available than positron emission tomography imaging, which is the current gold standard diagnostic test. The most evaluated treatment for cerebral misery perfusion is extracranial-intracranial bypass. Although previous trials of this have been unfavourable, the results of new studies involving extracranial-intracranial bypass in high-risk patients identified during cerebral perfusion imaging are awaited. Cerebral misery perfusion is an important and under-recognized condition in which emerging imaging and treatment modalities present the possibility of practical and evidence-based management in the near future. Physicians should thus be aware of this disorder and of recent developments in diagnostic tests that allow its detection.

  14. Frequency dependence of the magnetostrictive phenomenon in Metglas® 2605SA1 ribbon: A minor-loop case

    Directory of Open Access Journals (Sweden)

    S. U. Jen

    2014-12-01

    Full Text Available Frequency dependence of magnetostrictive phenomenon of as-cast 2605SA1 ribbon was studied. We applied a sinusoidal sweeping field (H, with a fixed frequency (f, along length (L of the ribbon, and simultaneously recorded the longitudinal magnetostriction (λ∥ and the transverse magnetostriction (λ⊥ as a function of time (t, respectively. f was varied from 0.07 to 122 Hz. In the low-f case (f =0.07 Hz, we observed the frequency-doubling (FD feature in λ∥(t and λ⊥(t curves; i.e., only even harmonic magnetostrictive signals showed up. In the high-f case (f = 122 Hz, we observed the no-frequency-doubling (NFD feature; i.e., both odd and even harmonic magnetostrictive signals showed up. A theory, based on the balance among various torques acting on magnetization, is developed to explain the f dependence of the magnetostriction phenomenon observed. From this theory, we conclude that only when the reflection symmetry of the system is reserved, i.e., when the equivalent easy axis (EEA is perpendicular to L, will λ∥(t and λ⊥(t have the true-frequency-doubling (TFD feature. However, for the as-cast 2605SA1 ribbon, EEA is not perpendicular to L. Thus, strictly speaking, we should observe the NFD feature only. Nevertheless, in the low-f limit, we can show that the FD feature is somewhat allowed under the condition, b/α being close to 1, where b and α are the two parameters used in the theory. From experimental data, this condition is met for as-cast 2605SA1. To make a distinction from TFD, this low-f feature is called close-frequency-doubling (CFD in this paper. In general, the theory explains all the experimental results fairly well.

  15. APPLICATION OF SOIL LOSS SCENARIOS USING THE ROMSEM MODEL DEPENDING ON MAXIMUM LAND USE PRETABILITY CLASSES. A CASE STUDY

    Directory of Open Access Journals (Sweden)

    SANDA ROȘCA

    2014-06-01

    Full Text Available Application of Soil Loss Scenarios Using the ROMSEM Model Depending on Maximum Land Use Pretability Classes. A Case Study. Practicing a modern agriculture that takes into consideration the favourability conditions and the natural resources of a territory represents one of the main national objectives. Due to the importance of the agricultural land, which prevails among the land use types from the Niraj river basin, as well as the pedological and geomorphological characteristics, different areas where soil erosion is above the accepted thresholds were identified by applying the ROMSEM model. In order to do so, a GIS database was used, regrouping quantitative information regarding soil type, land use, climate and hydrogeology, used as indicators in the model. Estimations for the potential soil erosion have been made on the entire basin as well as on its subbasins. The essential role played by the morphometrical characteristics has also been highlighted (concavity, convexity, slope length etc.. Taking into account the strong agricultural characteristic of the analysed territory, the scoring method was employed for the identification of crop favourability in the case of wheat, barley, corn, sunflower, sugar beet, potato, soy and pea-bean. The results have been used as input data for the C coefficient (crop/vegetation and management factor in the ROMSEM model that was applied for the present land use conditions, as well as for other four scenarios depicting the land use types with maximum favourability. The theoretical, modelled values of the soil erosion were obtained dependent on land use, while the other variables of the model were kept constant.

  16. [Femtosecond laser-assisted lens surgery depending on interface design and laser pulse energy: results of the first 200 cases].

    Science.gov (United States)

    Mayer, W J; Klaproth, O K; Ostovic, M; Hengerer, F H; Kohnen, T

    2014-12-01

    This study was designed to evaluate the effectiveness and safety of femtosecond laser-assisted lens surgery depending on interface design and laser pulse energy settings. In this non-randomized, consecutive case series200 eyes underwent femtosecond laser-assisted (LenSx, Alcon) lens surgery between November 2012 and June 2013. Group 1 consisted of 85 eyes with 60 cataracts and 25 refractive lens exchanges (RLE) which were treated with a curved direct contact interface, and group 2 consisting of 115 eyes with 72 cataracts and 43 RLEs treated with a modified interface using an additional soft contact lens (SoftFit™, Alcon) between the corneal surface and the interface. The degree of opacity of the lens in cataract eyes was measured with a Scheimpflug camera. Afterwards, phacoemulsification was performed with intraocular lens (IOL) implantation in all eyes. Primary endpoints were the effective phacoemulsification time (EPT), the average laser treatment time and the occurrence of intraoperative complications. The mean EPT in group 1 was 1.62 ± 1.12 s (cataract 1.94 ± 1.31 s, RLE 1.29 ± 1.01 s) and in group 2 the mean EPT was 1.66 ± 0.92 s (cataract 1.98 ± 1.28 s, RLE 1.33 ± 1.22 s, p = 0.32 between groups). The laser treatment lasted on average 48.90 ± 2.45 s (group 1) and 49.70 ± 2.87 s (group 2) with an average lens fragmentation thickness of 3401.48 ± 401.12 µm (all groups). In four cases of group 1, a second applanation of the interface was necessary. Furthermore, one anterior capsule tear, 39 cases of intraoperative wrinkling of the corneal surface and 21 cases in which the corneal incision had to be opened manually were documented in group 1. In group 2 no second applanation of the interface, no anterior capsule tears and no corneal wrinkling but 9 cases with a manual opening of corneal incisions were documented (p interface and reduced laser pulse energy.

  17. Which visual functions depend on intermediate visual regions? Insights from a case of developmental visual form agnosia.

    Science.gov (United States)

    Gilaie-Dotan, Sharon

    2016-03-01

    A key question in visual neuroscience is the causal link between specific brain areas and perceptual functions; which regions are necessary for which visual functions? While the contribution of primary visual cortex and high-level visual regions to visual perception has been extensively investigated, the contribution of intermediate visual areas (e.g. V2/V3) to visual processes remains unclear. Here I review more than 20 visual functions (early, mid, and high-level) of LG, a developmental visual agnosic and prosopagnosic young adult, whose intermediate visual regions function in a significantly abnormal fashion as revealed through extensive fMRI and ERP investigations. While expectedly, some of LG's visual functions are significantly impaired, some of his visual functions are surprisingly normal (e.g. stereopsis, color, reading, biological motion). During the period of eight-year testing described here, LG trained on a perceptual learning paradigm that was successful in improving some but not all of his visual functions. Following LG's visual performance and taking into account additional findings in the field, I propose a framework for how different visual areas contribute to different visual functions, with an emphasis on intermediate visual regions. Thus, although rewiring and plasticity in the brain can occur during development to overcome and compensate for hindering developmental factors, LG's case seems to indicate that some visual functions are much less dependent on strict hierarchical flow than others, and can develop normally in spite of abnormal mid-level visual areas, thereby probably less dependent on intermediate visual regions. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Relapsed acute promyelocytic leukemia in a hemodialysis-dependent patient treated with arsenic trioxide: a case report

    Directory of Open Access Journals (Sweden)

    Emmons Gregory S

    2012-10-01

    Full Text Available Abstract Introduction In the relapsed setting, arsenic trioxide remains the backbone of treatment. Scant literature exists regarding treatment of relapsed acute promyelocytic leukemia in patients with renal failure. To the best of our knowledge we are the first to report a safe and effective means of treatment for relapsed acute promyelocytic leukemia in the setting of advanced renal failure, employing titration of arsenic trioxide based on clinical parameters rather than arsenic trioxide levels. Case presentation A 33-year-old Caucasian man with a history of acute promyelocytic leukemia in remission for 3 years, as well as dialysis-dependent chronic renal failure secondary to a solitary kidney and focal segmental glomerulosclerosis and human immunodeficiency virus infection, receiving highly active antiretroviral therapy presented to our hospital with bone marrow biopsy-confirmed relapsed acute promyelocytic leukemia. Arsenic trioxide was begun at a low dose with dose escalation based only on side effect profile monitoring and not laboratory testing for induction as well as maintenance without undue toxicity. Our patient achieved and remains in complete hematologic and molecular remission as of this writing. Conclusion Arsenic trioxide can be used safely and effectively to treat acute promyelocytic leukemia in patients with advanced renal failure using careful monitoring of side effects rather than blood levels of arsenic to guide therapeutic dosing.

  19. Energetics and phasing of nonprecessing spinning coalescing black hole binaries

    CERN Document Server

    Nagar, Alessandro; Reisswig, Christian; Pollney, Denis

    2015-01-01

    We present an improved numerical relativity (NR) calibration of the new effective-one-body (EOB) model for coalescing non precessing spinning black hole binaries recently introduced by Damour and Nagar [Physical Review D 90, 044018 (2014)]. We do so by comparing the EOB predictions to both the phasing and the energetics provided by two independent sets of NR data covering mass ratios $1\\leq q \\leq 8$ and dimensionless spin range $-0.95\\leq \\chi\\leq +0.98$. One set of data is a subset of the Simulating eXtreme Spacetimes (SXS) catalog of public waveforms; the other set consists of new simulations obtained with the Llama code plus Cauchy Characteristic Evolution. We present the first systematic computation of the gauge-invariant relation between the binding energy and the total angular momentum, $E_{b}(j)$, for a large sample of, spin-aligned, SXS and Llama data. The EOB model presented here has only two calibration parameters, one entering the non spinning sector, as a 5PN effective correction to the interacti...

  20. [Description of a patient with schizophrenia and coexisting megadose lorazepam dependence with slightly expressed withdrawl symptoms during drug reduction. A case report].

    Science.gov (United States)

    Schylla, Aleksandra; Scisło, Piotr; Badura-Brzoza, Karina; Pasierb, Natalia

    2012-01-01

    The aim of this article is to present a patient with a megadose lorazepam dependence and slightly marked withdrawal symptoms during detoxication. The authors describe the case of 42 year old man who has been addicted to lorazepam (125 mg/d) for 2 years. On the ground of medical examination, anamnesis and hospital observation paranoid schizophrenia and lorazepam dependence syndrome was recognized. Despite relatively rapid reduction of lorazepam the withdrawal symptoms were slightly expressed. At the beginning of detoxication sleep disorders, feeling of "less looseness" and anxiety was observed. Review of medical database revealed other cases of megadose lorazepam dependence (95-300 mg/d). However in those cases withdrawal symptoms were distinct and the medical intervention was needed.

  1. Novel mutations in cyclin-dependent kinase-like 5 (CDKL5) gene in Indian cases of Rett syndrome.

    Science.gov (United States)

    Das, Dhanjit Kumar; Mehta, Bhakti; Menon, Shyla R; Raha, Sarbani; Udani, Vrajesh

    2013-03-01

    Rett syndrome is a severe neurodevelopmental disorder, almost exclusively affecting females and characterized by a wide spectrum of clinical manifestations. Both the classic and atypical forms of Rett syndrome are primarily due to mutations in the methyl-CpG-binding protein 2 (MECP2) gene. Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene have been identified in patients with atypical Rett syndrome, X-linked infantile spasms sharing common features of generally early-onset seizures and mental retardation. CDKL5 is known as serine/threonine protein kinase 9 (STK9) and is mapped to the Xp22 region. It has a conserved serine/threonine kinase domain within its amino terminus and a large C-terminal region. Disease-causing mutations are distributed in both the amino terminal domain and in the large C-terminal domain. We have screened the CDKL5 gene in 44 patients with atypical Rett syndrome who had tested negative for MECP2 gene mutations and have identified 6 sequence variants, out of which three were novel and three known mutations. Two of these novel mutations p.V966I and p.A1011V were missense and p.H589H a silent mutation. Other known mutations identified were p.V999M, p.Q791P and p.T734A. Sequence homology for all the mutations revealed that the two mutations (p.Q791P and p.T734A) were conserved across species. This indicated the importance of these residues in structure and function of the protein. The damaging effects of these mutations were analysed in silico using PolyPhen-2 online software. The PolyPhen-2 scores of p.Q791P and p.T734A were 0.998 and 0.48, revealing that these mutations could be deleterious and might have potential functional effect. All other mutations had a low score suggesting that they might not alter the activity of CDKL5. We have also analysed the position of the mutations in the CDKL5 protein and found that all the mutations were present in the C-terminal domain of the protein. The C-terminal domain is required for

  2. Clinical features and the management of pyridoxine-dependent and pyridoxine-responsive seizures: review of 63 North American cases submitted to a patient registry.

    Science.gov (United States)

    Basura, Gregory J; Hagland, Shawn P; Wiltse, Anna M; Gospe, Sidney M

    2009-06-01

    To facilitate clinical research on pyridoxine-dependent seizures (PDS), a rare disease registry was established for affected patients in the United States and Canada. From 1999 to 2007, 63 cases, ranging in age from 11 months to 40 years, were registered. All registered cases were diagnosed with PDS by their physicians using clinical criteria. Seventy percent of the cases presented with neonatal seizures, and the mean lag time between presentation and diagnosis was 313 days. Pyridoxine treatment regimens were varied, ranging from 50 to 2,500 mg per day (1.4 to 67.8 mg/kg/day). While 47 of the cases were seizure-free on pyridoxine monotherapy, over time, eight other cases also required the concomitant use of anticonvulsants for effective seizure control, while the remainder continued to have recurrent seizures, despite the use of pyridoxine and multiple anticonvulsants. Our review of this collection of cases suggests that, for some registered individuals, either pyridoxine may be acting as an adjunctive anticonvulsant or the patient may have developed a secondary etiology for seizures. In addition, some of these cases may have pyridoxine-responsive seizures (PRS) rather than pyridoxine-dependency. Four adult and seven school-aged cases were described as developmentally normal, while the other cases had a variety of neurodevelopmental handicaps. Twenty-five percent of the cases required the pharmacologic treatment of behavioral symptoms. Clinicians caring for neonates and other young patients with intractable seizures do not necessarily consider PDS as an etiology; therefore, certain cases may be undiagnosed or diagnosed late in the course of their evaluation and treatment. As the diagnosis of PDS can now be confirmed by genetic and biochemical testing, formal screening protocols for this disorder should be developed. Patients previously diagnosed with PDS by clinical criteria should also receive confirmatory testing.

  3. Regarding the use and misuse of retinal protonated Schiff base photochemistry as a test case for time-dependent density-functional theory

    NARCIS (Netherlands)

    Valsson, O.; Filippi, C.; Casida, M.E.

    2015-01-01

    The excited-state relaxation of retinal protonated Schiff bases (PSBs) is an important test case for biological applications of time-dependent (TD) density-functional theory (DFT). While well-known shortcomings of approximate TD-DFT might seem discouraging for application to PSB relaxation, progress

  4. Consumer Perception Concerning Apple Fruit Quality, Depending on Cultivars and Hedonic Scale of Evaluation - a Case Study

    Directory of Open Access Journals (Sweden)

    Cătălina DAN

    2015-03-01

    Full Text Available The objective of this study was to analyse fruit quality through consumers’ perceptions and their preferences revealed by two panel questionnaires. Among the most common apple cultivars on the Romanian markets, were chosen the ones existing simultaneously and continuously (over two-years, during January-March: ‘Golden Delicious’, ‘Braeburn’, ‘Granny Smith’, ‘Red Delicious’, ‘Jonagold’, ‘Jonathan’, ‘Florina’, ‘Idared’. The consumers’ panel for sensory evaluation was represented by students, who completed two types of questionnaires. Both questionnaires refer to foremost traits for dessert apple, such as fruit appearance (size, shape, color and intrinsic peculiarities (pulp consistency, juiciness, taste, flavor. First questionnaire comprised different scales for the traits (1-3, 1-5 or 1-15, while the second one consisted of the hedonic scale (1-9 for all traits. For commercial appearance of the fruits were highlighted ‘Idared’, ‘Granny Smith’, ‘Braeburn’ and especially ‘Jonagold’. ‘Braeburn’ was distinct by the highest quality taste (average grade 13.9 on the scoring taste scale 1-15 and also for fruit flavor. ‘Granny Smith’, a commercially attractive-looking fruit, received only an average of 6.2 for taste and 2.6 for flavor. ‘Granny Smith’ presented the largest value for the coefficients of variation for taste, this variety being preferred less by female than male tasters. Inconsistency of the market, prices and foreign assortment on Romanian market was illustrated by the lack of statistical correlations between commercial fruit quality and price. The study could provide useful background information for apples breeders, farmers and marketing fruits strategy. The use of different scales for panel evaluation, dependent on the relevance of traits, might be a proper solution for reducing bias. In this case, the 1-15 large scale for apple taste compared with lower ones for other traits

  5. Path dependence and the geography of infrastructure networks: the case of the European fibre-optic network

    NARCIS (Netherlands)

    Vinciguerra, S.; Frenken, K.

    2015-01-01

    We analyse the path dependent dynamics in the formation of new infrastructure using an augmented gravity model. We observe that the formation of the pan-European telecommunication backbone has been dependent on pre-existent European transportation networks, particularly, the maritime and railway net

  6. A Comparative study of Personality as a common pathway in HIV Sero-positive and Alcohol dependent cases on Five Factor Model

    Directory of Open Access Journals (Sweden)

    Kalpana Srivastava

    2016-01-01

    Full Text Available Aim: The aim of this study was to identify the personality traits of alcohol and human immunodeficiency virus (HIV-positive patients and to compare them with normal controls. Materials and Methods: This cross-sectional study included 100 consecutive patients with alcohol dependence and HIV each and a control group of 100 normal cases without any physical or psychiatric illness. A score of 2 or less on the General Health Questionnaire was taken as cutoff, and the participants were included in the study with written informed consent. All participants were assessed with the NEO personality inventory revised and sensation-seeking scale (SSS. Results: There were significant differences among the study group on all the five factors, i.e., neuroticism (N, extraversion (E, conscientiousness (C, openness to experience (O, and agreeableness (A. On factor “N,” HIV and alcohol group scored significantly more as compared to normal group. Odds ratio revealed high neuroticism to be a risk factor in alcohol-dependent and HIV cases (P < 0.05. The normal group scored significantly higher on factor “E” as compared to HIV and alcohol cases. High scores on factor “E” and “C” have a protective. Odds ratio found low score of factor “C” as a risk factor; however, “O” did not emerge as a risk factor. The logistic regression revealed that high scores on “N” and “E” and low “A” score had a significant association with alcohol dependence (P < 0.05. Among HIV cases, high score on “N” and “E” and low “C” score emerged significant. Alcohol cases scored significantly more on boredom susceptibility (BS on SSS as compared to HIV and normal controls. On disinhibition (DIS, HIV cases and alcohol cases scored significantly higher as compared to normal group (P < 0.05. Conclusion: High “N” scores on NEO personality inventory are significantly associated with alcohol dependence and HIV while high scores on “E” and “C” have a

  7. Definition of drug resistance of Mycobacterium tuberculosis to antituberculosis drugs in patients with multidrugresistant tuberculosis and TB with extremely drug resistant depending on the case of the disease

    Directory of Open Access Journals (Sweden)

    Kryzhanovsky D.G.

    2014-11-01

    Full Text Available There was studied the profile of drug resistance to the main (I line and reserve (II line antituberculosis drugs in patients with MDR and XDR tuberculosis, depending of the case of the disease. According to the randomized retrospective research 200 patients with MDR and XDR tuberculosis, who received treatment in the clinic of hospital Municipal institution «Dnipropetrovsk rigional clinical association «Phthisiology» Dnipropetrovsk regional Council» during the period 2010 – 2012 were involved. Data about patients contained the data on a case of the disease and the results of the test of drug sensitivity to MBT. XDR – TB was revealed in 7.5% of patients with MDR tuberculosis. In patients with MDR tuberculosis as compared with patients with XDR tuberculosis «new cases» were diagnosed in 19.5% against 18.5% (p <0.05. In patients with MDR tuberculosis and with XDR tuberculosis resistance to the antituberculosis drug more commonly developed to S - 88.5%, E - 55% and Z - 24%. The presence of MDR-TB and XDR-TB prevails in patients, who underwent previous courses of treatment with anti-TB drugs in case history as compared with patients with «new cases» of treatment. The development of resistance to anti-TB drugs depends on the availability of these drugs in the previous treatment regimens.

  8. The effect of attitudes on reference-dependent preferences: Estimation and validation for the case of alternative-fuel vehicles

    DEFF Research Database (Denmark)

    Mabit, Stefan Lindhard; Cherchi, Elisabetta; Jensen, Anders Fjendbo;

    2015-01-01

    reference-dependent preferences and attitudes together may explain individual choices. In a modelling framework based on a hybrid choice model allowing for both concepts, we investigate how attitudes and reference-dependent preferences interact and how they affect willingness-to-pay measures and demand...... of attitudes improves the models' ability to explain behaviour in the hold-out sample. While neither reference-dependent preferences nor the attitude affect the average willingness-to-pay measures in our sample, their effect on choice behaviour has implications for policy recommendations as segments...... with varying attitudes and reference values will act differently when affected by policy instruments related to the demand for alternative-fuel vehicles, e.g. subsidies....

  9. The effect of attitudes on reference-dependent preferences: Estimation and validation for the case of alternative-fuel vehicles

    DEFF Research Database (Denmark)

    Mabit, Stefan Lindhard; Cherchi, Elisabetta; Jensen, Anders Fjendbo

    2015-01-01

    reference-dependent preferences and attitudes together may explain individual choices. In a modelling framework based on a hybrid choice model allowing for both concepts, we investigate how attitudes and reference-dependent preferences interact and how they affect willingness-to-pay measures and demand...... elasticities. Using a data set with stated choices among alternative-fuel vehicles, we see that allowing for reference-dependent preferences improves our ability to explain the stated choices in the data and that the attitude (appreciation of car features) explains part of the preference heterogeneity across...... with varying attitudes and reference values will act differently when affected by policy instruments related to the demand for alternative-fuel vehicles, e.g. subsidies....

  10. 基于流程案例簇的任务关系挖掘算法%Mining algorithm of task dependencies based on process case clusters

    Institute of Scientific and Technical Information of China (English)

    鲁法明; 曾庆田; 包云霞; 段华; 张昊

    2013-01-01

    To make process discovery,a case cluster-based derivation method of task dependencies was presented.The basic cases were classified into case clusters according to feature vectors.According to task traces of basic cases,task dependencies among case clusters were mined,and a modeling and discovery approach of loop structures based on loop-unit was proposed.All the task dependencies and loop structures in processes were generated from event logs.Compared to the existing methods,the proposed method could correctly handle such situations that task dependencies change with case attribute values.Based on the mined task dependencies and loop structure,a behavior-equivalent process model was obtained as long as the event log was complete.%为了进行流程发现,提出一种基于流程案例簇的任务关系挖掘方法.该方法首先将基本案例按照特征向量分为多个案例簇,根据基本案例的任务轨迹对案例簇中任务间的依赖关系进行挖掘;然后给出了基于循环基元的循环结构建模和挖掘方法,最终可以从事件日志导出流程中完整的任务依赖关系以及存在的循环结构.所提方法能正确处理任务依赖关系随案例属性取值不同而变化的情况.只要日志完备,基于挖掘到的任务关系和循环结构就能得到一个与原流程行为等价的流程模型.

  11. Policy Path Dependence of a Research Agenda: The Case of Chile in the Aftermath of the Student Revolt of 2011

    Science.gov (United States)

    Bernasconi, Andres

    2014-01-01

    The rapidly shifting higher education policy agenda in the aftermath of the students' movement of 2011 in Chile and its mismatch with Chile's research capacities in the field of higher education studies are analyzed to illustrate how research is path dependent on policy. I argue that a stable policy environment, where change is only marginal or…

  12. Scale dependence in habitat selection: The case of the endangered brown bear (Ursus arctos) in the Cantabrian Range (NW Spain)

    Science.gov (United States)

    Maria C. Mateo Sanchez; Samuel A. Cushman; Santiago Saura

    2013-01-01

    Animals select habitat resources at multiple spatial scales. Thus, explicit attention to scale dependency in species-habitat relationships is critical to understand the habitat suitability patterns as perceived by organisms in complex landscapes. Identification of the scales at which particular environmental variables influence habitat selection may be as important as...

  13. Solute redistribution around a parabolic dendrite in the case of thermodiffusion (Soret effect) and temperature-dependent diffusivity

    Science.gov (United States)

    Alexandrov, D. V.; Alexandrova, I. V.

    2017-07-01

    An exact analytical solution of a thermo-diffusional problem describing the steady-state growth of a free dendrite into a binary mixture under forced viscous flow is found with allowance for the effects of thermodiffusion and temperature-dependent diffusivity. We demonstrate that the non-linear mass transfer substantially change the solute concentration.

  14. On solving energy-dependent partitioned eigenvalue problem by genetic algorithm: The case of real symmetric Hamiltonian matrices

    Indian Academy of Sciences (India)

    Rahul Sharma; Subbajit Nandy; S P Bhattacharyya

    2006-06-01

    An energy-dependent partitioning scheme is explored for extracting a small number of eigenvalues of a real symmetric matrix with the help of genetic algorithm. The proposed method is tested with matrices of different sizes (30 × 30 to 1000 × 1000). Comparison is made with Löwdin's strategy for solving the problem. The relative advantages and disadvantages of the GA-based method are analyzed.

  15. Nonlinear Stochastic H∞ Control with Markov Jumps and (x,u,v-Dependent Noise: Finite and Infinite Horizon Cases

    Directory of Open Access Journals (Sweden)

    Li Sheng

    2014-01-01

    Full Text Available This paper is concerned with the H∞ control problem for nonlinear stochastic Markov jump systems with state, control, and external disturbance-dependent noise. By means of inequality techniques and coupled Hamilton-Jacobi inequalities, both finite and infinite horizon H∞ control designs of such systems are developed. Two numerical examples are provided to illustrate the effectiveness of the proposed design method.

  16. Is an "ideal" service institution image the same for all referral sources? The case of chemical dependency treatment programs.

    Science.gov (United States)

    Johnson, K; LaTour, M S

    1993-01-01

    In a competitive market like chemical dependency treatment, segmenting the professional referral market according to an "ideal" service image may offer a service institution a strategic advantage. Results of this study suggest that while different professionals in a referral market may attach differential importance to the same service feature, a favorable or unfavorable "image" seems to encompass how well both the professional and the professionals' client are treated by the service institution.

  17. Smoking, Alcohol, Drug Use, Abuse and Dependence in Narcolepsy and Idiopathic Hypersomnia: A Case-Control Study.

    Science.gov (United States)

    Barateau, Lucie; Jaussent, Isabelle; Lopez, Régis; Boutrel, Benjamin; Leu-Semenescu, Smaranda; Arnulf, Isabelle; Dauvilliers, Yves

    2016-03-01

    Basic experiments support the impact of hypocretin on hyperarousal and motivated state required for increasing drug craving. Our aim was to assess the frequencies of smoking, alcohol and drug use, abuse and dependence in narcolepsy type 1 (NT1, hypocretin-deficient), narcolepsy type 2 (NT2), idiopathic hypersomnia (IH) (non-hypocretin-deficient conditions), in comparison to controls. We hypothesized that NT1 patients would be less vulnerable to drug abuse and addiction compared to other hypersomniac patients and controls from general population. We performed a cross-sectional study in French reference centres for rare hypersomnia diseases and included 450 adult patients (median age 35 years; 41.3% men) with NT1 (n = 243), NT2 (n = 116), IH (n = 91), and 710 adult controls. All participants were evaluated for alcohol consumption, smoking habits, and substance (alcohol and illicit drug) abuse and dependence diagnosis during the past year using the Mini International Neuropsychiatric Interview. An increased proportion of both tobacco and heavy tobacco smokers was found in NT1 compared to controls and other hypersomniacs, despite adjustments for potential confounders. We reported an increased regular and frequent alcohol drinking habit in NT1 versus controls but not compared to other hypersomniacs in adjusted models. In contrast, heavy drinkers were significantly reduced in NT1 versus controls but not compared to other hypersomniacs. The proportion of patients with excessive drug use (codeine, cocaine, and cannabis), substance dependence, or abuse was low in all subgroups, without significant differences between either hypersomnia disorder categories or compared with controls. We first described a low frequency of illicit drug use, dependence, or abuse in patients with central hypersomnia, whether Hcrt-deficient or not, and whether drug-free or medicated, in the same range as in controls. Conversely, heavy drinkers were rare in NT1 compared to controls but not to other

  18. Comparison principles for integro-differential equations with L{\\'e}vy operators - the case of spacial depending jumps -

    CERN Document Server

    Arisawa, M

    2010-01-01

    A comparison principle for the integro-differential equation with the L{\\'e}vy operator corresponding to the spacial depending jump process is presented in this paper. The jump $\\beta(x,z)$ at a point $x$ and the L{\\'e}vy measure $dq(z)$ satisfy conditions given independently for each of them, which is a major difference from other works. Moreover, a useful form of the viscosity solution is presented, which is equivalent to more "classical" definitions, and is used to prove the comparison principle easily.

  19. The vulnerability of a groundwater dependent terrestrial ecosystem to chemical and quantitative anthropogenic pressures: case study from southern Poland

    Science.gov (United States)

    Zurek, Anna J.; Wachniew, Przemyslaw; Witczak, Stanislaw

    2016-04-01

    The protected Wielkie Bloto fen in southern Poland is a Groundwater Depended Terrestrial Ecosystem (GDTE). The vulnerability of this GDTE was assessed in the contexts of both quality and quantity of groundwater supporting the fen. The qualitative aspect of vulnerability was assessed with an approach based on evaluation of timescales of pollution transport in the aquifer supporting the ecosystem with groundwater. Assessment of the quantitative aspect was based on the conceptualization of the relations of the Wielkie Bloto fen to the underlying groundwater system. The fen relies on groundwater from a shallow Quaternary aquifer and from the deeper Neogene aquifer. Upward leakage from the Neogene to the Quaternary aquifer and to the fen was confirmed by multidisciplinary research (Zurek et al. 2015). In July 2009 a cluster of new pumping wells abstracting water from the Neogene aquifer was commissioned 1 km north of the edge of Wielkie Bloto fen. Consequently, lowering of water levels occurred in this aquifer. However, it remains unclear whether the fen ecosystem will be affected by the pumping. The objective of the study was to assess the dependence of the fen on groundwater. The spatial distribution of physico-chemical parameters of water (pH, conductivity, Na/Cl ratio) in the fen area suggests that the degree of dependence on groundwater is strongly heterogeneous spatially and the recharge rate from the deeper aquifer varies considerably. Groundwater contributions to the fen, which can be used as an indicator of GDTE vulnerability, were quantified and mapped. Acknowledgements. The work was carried out as part of the statutory funds of the AGH University of Science and Technology (project No.11.11.140.026 and 11.11.220.01). References: Zurek A.J., Witczak S., Dulinski M., Wachniew P., Rozanski K., Kania J., Postawa A., Karczewski J., and Moscicki W.J.: 2015. Quantification of anthropogenic impact on groundwater dependent terrestrial ecosystem using geochemical and

  20. EDTA依赖性血小板假性降低一例%A case of EDTA-dependent pseudothrombocytopenia

    Institute of Scientific and Technical Information of China (English)

    杨一芬

    2003-01-01

    @@ 应用全自动血细胞分析仪做血常规时,一般采用EDTA*K2作为抗凝剂,但对于较为罕见的EDTA依赖性血小板假性降低(EDTA-dependent pseudothrombo cytopenia, EDTA-PTCP),血小板计数会产生较大的误差[1].现将我院发现的一例EDTA-PTCP患者用仪器法和许汝和直接计数法进行血小板测定和比较,报告如下.

  1. Transtornos mentais como fatores de risco para o desenvolvimento de abuso/dependência de cocaína: estudo caso-controle Mental disorders as risk factors for the development of cocaine abuse/dependence: case-control study

    Directory of Open Access Journals (Sweden)

    Claudia S Lopes

    1999-10-01

    Full Text Available OBJETIVO: Avaliar o papel dos transtornos mentais e da dependência ao álcool como possíveis fatores de risco para o abuso/dependência de cocaína. MÉTODOS: Utilizou-se o desenho caso-controle e a técnica de bola-de-neve (snowball technique para selecionar uma amostra de usuários de cocaína não tratados na comunidade (casos e parear casos e controles por sexo, idade e amizade. A coleta de dados foi feita através da utilização do questionário CIDI (Composite International Diagnostic Interview que gera diagnósticos de acordo com os critérios do Diagnostic and Statistical Manual of Mental Disorders-III-R. A análise dos dados foi feita através de regressão logística condicional. RESULTADOS: O estudo incluiu 208 indivíduos. Os principais resultados mostraram que história passada de dependência ao álcool era o principal fator associado a um aumento no risco de desenvolvimento de abuso de cocaína (OR=15,1; IC 95% 3,8-60,2; nenhum outro transtorno mental isolado manteve-se significativamente associado ao aumento deste risco após a análise multivariada. Aumento no risco de abuso de cocaína também foi encontrado entre os indivíduos que relataram pensamentos suicidas (OR=3,1; IC 95% 0,91-10,8, sugerindo associação entre quadros mais graves de depressão e abuso de cocaína. CONCLUSÕES: Esses achados sugerem que os programas voltados para a prevenção e tratamento do abuso de cocaína devem estar preparados para o manejo de questões relacionadas à co-morbidade do abuso de drogas com o álcool e outros distúrbios psiquiátricos.OBJECTIVE: To evaluate the role of psychiatric disorders and alcohol dependence as possible risk factors for cocaine abuse/dependence. METHODS: The case-control study used the "snowball" technique in order to select untreated cocaine users (cases and to match sex, age and friendship. Information was gathered using the Composite International Diagnostic Interview (CIDI, and computer diagnosis were

  2. Development of a Time-Dependent 3-PARAMETER Helmert Datum Transformation Model: a Case Study for Malaysia

    Science.gov (United States)

    Gill, J.; Shariff, N. S.; Omar, K. M.; Din, A. H. M.; Amin, Z. M.

    2016-09-01

    This paper aims to develop a time-dependent 3-parameter Helmert datum transformation model for Malaysia as a proposed solution to the current non-geocentric issue of the Geocentric Datum of Malaysia 2000 (GDM2000). Methodologically, the datum transformation models is categorised into three parts; firstly, the time-dependent aspect of the datum transformation model is determined using the tectonic motion velocities computed from linear least squares regression of the long-term time series of MyRTKnet stations positions from year December 2004 to 2014; whereby the station positions are obtained from high-precision daily double-difference processing of MyRTKnet and IGS stations via Bernese 5.0. Secondly, the 3 Helmert translation-only parameters, are derived between the original GDM2000 and GDM2000@2013 - the new datum coordinates which refers to ITRF2008 at epoch 3/7/2013 - via Bernese 5.0 software. Thirdly, a distortion model is computed in order to minimise the coordinate residuals between the `processed' and `transformed' new datum. The datum transformation model is then validated to determine the reliability of the model. The validation results show that the datum transformation model is within centimetre-level accuracy, i.e., below 3 cm, over Malaysia for forward transformations to year 2014 and 2015. Therefore, this study anticipates that it will contribute as a feasible solution for the GDM2000 issue with consideration of the core concern: the complex tectonic motion of Malaysia.

  3. Anxiety disorders are associated with quality of life impairment in patients with insulin-dependent type 2 diabetes: a case-control study

    Directory of Open Access Journals (Sweden)

    Maria Augusta B. dos Santos

    2014-12-01

    Full Text Available Objective: To assess the presence of anxiety disorders and quality of life in patients with insulin-dependent type 2 diabetes. Methods: Case-control study of 996 patients with type 2 diabetes and 2,145 individuals without diabetes. The sole inclusion criterion for the case group was insulin-dependent type 2 diabetes. We compared the case and control groups for sociodemographic variables, laboratory and clinical data, and presence of anxiety disorders. Quality of life was evaluated using the WHOQOL-BREF instrument, and the prevalence of anxiety disorder was evaluated by the Mini International Neuropsychiatric Interview (MINI. Results: Patients with diabetes had a higher prevalence of generalized anxiety disorder, panic disorder, and obsessive-compulsive disorder. The presence of these disorders in combination with type 2 diabetes was associated with worse quality of life in the physical, social, psychological, and environmental domains. Conclusions: This study demonstrates the importance of diagnosing and treating anxiety disorders in patients with diabetes, so as to prevent more serious complications associated with these comorbidities.

  4. Pregnancy in dialysis-dependent women--the importance of frequent dialysis and collaborative care: a case report.

    Science.gov (United States)

    Pipili, Chrisoula; Grapsa, Eirini; Koutsobasili, Alexandra; Sorvinou, Patra; Poirazlar, Engin; Kiosses, Dimitrios; Xatzigeorgiou, Georgia

    2011-07-01

    An increasing number of successful pregnancies have been reported among women on chronic hemodialysis. Even with reduced fertility and high risk of complications, women of childbearing age receiving hemodialysis, should not be discouraged from pregnancy. Practitioners should be familiar with the effects of renal disease on pregnancy, consult patients about the possibility of pregnancy and its hazards and provide, if necessary, prompt surveillance and treatment. This paper describes the case of an unplanned but successful pregnancy of a woman receiving hemodialysis, emphasizing pregnancy management, mother's response evaluation, and infant growth.

  5. Hypophosphatemia Dependent Rickets with Failure to Thrive (FTT in a 4- Years Old Child: a Case Report

    Directory of Open Access Journals (Sweden)

    Fereshteh Ghaljaei

    2017-02-01

    Full Text Available BackgroundRickets is a disorder due to impaired metabolism of bone mineralization which caused by low concentrations of extra-cellular calcium or phosphate. In children, hypophosphatemic rickets (HR happen malabsorption of phosphate and increasing of renal tubular loss.Case Presentation We present the case of a 4-year-old girl who had medical history of HR with failure to thrive (FTT. Child hospitalized several times due to osteomalacia and leg fractures. In physical examinations, there were obvious signs of rickets such as bow legs and hands, deviations of the wrist and chest pigeon. The results of blood tests showed low level of Phosphorus; but the level of calcium was normal. Radiography showed deformity of wrists and hands. ConclusionHR should be considered as one of the childhood disorders which impairs metabolism of bone mineralization and cause osteomalacia and bones fractures. If HR undiagnosed and remedies poor during childhood, in older ages would reveal automatic fractures and mineralization defects.

  6. Neurobehavioral phenotype in cyclin-dependent kinase-like 5 syndrome: Case report and review of literature

    Directory of Open Access Journals (Sweden)

    Annio Posar

    2015-01-01

    Full Text Available The phenotype of cyclin-dependent kinase-like 5 (CDKL5 syndrome includes Rett syndrome variant with early onset seizures, early onset epileptic encephalopathy; and severe developmental delay. Autistic features have often been reported in literature, but detailed reports of the behavior of these individuals are lacking. We describe the clinical picture of a girl aged 15 years 9 months affected by CDKL5 syndrome, with special attention to the neurobehavioral phenotype. The evaluation showed, apart from a profound intellectual disability, the presence of atypical features of behavior, mainly in relating to people, in imitation, and in verbal and nonverbal communication, thus justifying the diagnosis of comorbid autism spectrum disorder. A formal assessment of the behavior, through appropriate tools, is necessary to choose the most appropriate rehabilitative intervention and to characterize in more detail the CDKL5 syndrome phenotype. We propose a testing protocol for the neurobehavioral assessment of these patients.

  7. DEVELOPMENT OF A TIME-DEPENDENT 3-PARAMETER HELMERT DATUM TRANSFORMATION MODEL: A CASE STUDY FOR MALAYSIA

    Directory of Open Access Journals (Sweden)

    J. Gill

    2016-09-01

    Full Text Available This paper aims to develop a time-dependent 3-parameter Helmert datum transformation model for Malaysia as a proposed solution to the current non-geocentric issue of the Geocentric Datum of Malaysia 2000 (GDM2000. Methodologically, the datum transformation models is categorised into three parts; firstly, the time-dependent aspect of the datum transformation model is determined using the tectonic motion velocities computed from linear least squares regression of the long-term time series of MyRTKnet stations positions from year December 2004 to 2014; whereby the station positions are obtained from high-precision daily double-difference processing of MyRTKnet and IGS stations via Bernese 5.0. Secondly, the 3 Helmert translation-only parameters, are derived between the original GDM2000 and GDM2000@2013 – the new datum coordinates which refers to ITRF2008 at epoch 3/7/2013 – via Bernese 5.0 software. Thirdly, a distortion model is computed in order to minimise the coordinate residuals between the ‘processed’ and ‘transformed’ new datum. The datum transformation model is then validated to determine the reliability of the model. The validation results show that the datum transformation model is within centimetre-level accuracy, i.e., below 3 cm, over Malaysia for forward transformations to year 2014 and 2015. Therefore, this study anticipates that it will contribute as a feasible solution for the GDM2000 issue with consideration of the core concern: the complex tectonic motion of Malaysia.

  8. Pyridoxine-dependent seizures caused by alpha amino adipic semialdehyde dehydrogenase deficiency: the first polish case with confirmed biochemical and molecular pathology.

    Science.gov (United States)

    Kaczorowska, Magdalena; Kmiec, Tomasz; Jakobs, Cornelis; Kacinski, Marek; Kroczka, Slawomir; Salomons, Gajja S; Struys, Eduard A; Jozwiak, Sergiusz

    2008-12-01

    Pyridoxine-dependent seizures are a rare condition recognized when numerous seizures respond to pyridoxine treatment and recur on pyridoxine withdrawal. For decades the diagnosis was confirmed only with pyridoxine treatment withdrawal trial. Recently described biochemical and molecular pathology improved the diagnostic process for those cases in which seizures are caused by alpha amino adipic semialdehyde dehydrogenase deficiency. This article presents a girl with recurrent status epilepticus episodes resistant to phenobarbital and phenytoin and partly responding to midazolam. Eventually the seizures were completely controlled with pyridoxine; however, due to the severe condition of this child when seizing, no trial of withdrawal has been performed. The diagnosis of pyridoxine-dependent seizures was confirmed with biochemical and molecular testing revealing elevated alpha-AASA excretion and the presence of 2 different mutations in the antiquitin ( ALDH7A1) gene. Due to the availability of reliable laboratory testing, confirmation of the diagnosis was made without the life-threatening trial of pyridoxine withdrawal.

  9. Time-dependent renormalized natural orbital theory applied to the two-electron spin-singlet case: ground state, linear response, and autoionization

    CERN Document Server

    Brics, M

    2013-01-01

    Favorably scaling numerical time-dependent many-electron techniques such as time-dependent density functional theory (TDDFT) with adiabatic exchange-correlation potentials typically fail in capturing highly correlated electron dynamics. We propose a method based on natural orbitals, i.e., the eigenfunctions of the one-body reduced density matrix, that is almost as inexpensive numerically as adiabatic TDDFT, but which is capable of describing correlated phenomena such as doubly excited states, autoionization, Fano profiles in the photoelectron spectra, and strong-field ionization in general. Equations of motion (EOM) for natural orbitals and their occupation numbers have been derived earlier. We show that by using renormalized natural orbitals (RNO) both can be combined into one equation governed by a hermitian effective Hamiltonian. We specialize on the two-electron spin-singlet system, known as being a "worst case" testing ground for TDDFT, and employ the widely used, numerically exactly solvable, one-dimens...

  10. Dependencia de la gasolina. Presentación de un caso. Dependence on gasoline. A case report.

    Directory of Open Access Journals (Sweden)

    Ariel Acosta González

    2011-10-01

    work is aimed at presenting the case of a 13 years old boy with a dependence on gasoline aspiration. During physical examination, typical characteristics of intoxication were found, which corroborated the reason why the child had been taken to consultation. While being hospitalized, the patient displayed symptoms of mild psychomotor agitation that were controlled with low doses of anxiolytics. The various interviews showed that the patient came from a dysfunctional family, which affected his mental health. Drug treatment and psychotherapy allowed the teenager to suppress gasoline inhalation. The literature review and consultation to the National Institute of Toxicology reported no evidence of similar cases being published in Cuba before.

  11. The long-term and extensive efficacy of low dose thalidomide in a case of an untransfusable patient with Non-Transfusion-Dependent Thalassemia.

    Science.gov (United States)

    Ricchi, Paolo; Costantini, Silvia; Spasiano, Anna; De Dominicis, Gianfranco; Di Matola, Tiziana; Cinque, Patrizia; Ammirabile, Massimiliano; Marsella, Maria; Filosa, Aldo

    2016-03-01

    Patients with Non-Transfusion-Dependent Thalassemia may require regular transfusion therapy. However, these patients are at risk of developing irregular antibodies, making them untransfusable. Second line treatment usually includes hydroxyurea, which however is not effective in all patients. Other treatment options include thalidomide, which has been reported to be safe and effective in selected patients. We report the case of a patient who experienced improvement of hemoglobin levels and of a part of NTDT related complications, following 36months of continuous therapy with low doses of thalidomide.

  12. The importance of taking a history of over-the-counter medication use: a brief review and case illustration of "PRN" antihistamine dependence in a hospitalized adolescent.

    Science.gov (United States)

    Gracious, Barbara; Abe, Naomi; Sundberg, Jane

    2010-12-01

    Over-the-counter (OTC) and prescription medication abuse has been rapidly increasing, yet publications on OTC abuse in adolescents are limited. We present a brief literature review and a novel report of antihistamine dependence emerging after admission in an adolescent, subsequently treated with naltrexone. This case highlights the need to take a thorough history of OTC, herbal, and prescription drug use from parents and patients separately and repeatedly, at initial presentation, and again if withdrawal symptoms emerge. General strategies for combating OTC and prescription abuse are given.

  13. On the geometrical representation of the path integral reduction Jacobian: The case of dependent coordinates in the description of the reduced motion

    CERN Document Server

    Storchak, S N

    2008-01-01

    The geometrical representation of the path integral reduction Jacobian obtained in the problem of the path integral quantization of a scalar particle motion on a smooth compact Riemannian manifold with the given free isometric action of the compact semisimple Lie group has been found for the case when the local reduced motion is described by means of dependent coordinates. The result is based on the scalar curvature formula for the original manifold which is viewed as a total space of the principal fibre bundle.

  14. Model Related Estimates of time dependent quantiles of peak flows - case study for selected catchments in Poland

    Science.gov (United States)

    Strupczewski, Witold G.; Bogdanowich, Ewa; Debele, Sisay

    2016-04-01

    Under Polish climate conditions the series of Annual Maxima (AM) flows are usually a mixture of peak flows of thaw- and rainfall- originated floods. The northern, lowland regions are dominated by snowmelt floods whilst in mountainous regions the proportion of rainfall floods is predominant. In many stations the majority of AM can be of snowmelt origin, but the greatest peak flows come from rainfall floods or vice versa. In a warming climate, precipitation is less likely to occur as snowfall. A shift from a snow- towards a rain-dominated regime results in a decreasing trend in mean and standard deviations of winter peak flows whilst rainfall floods do not exhibit any trace of non-stationarity. That is why a simple form of trends (i.e. linear trends) are more difficult to identify in AM time-series than in Seasonal Maxima (SM), usually winter season time-series. Hence it is recommended to analyse trends in SM, where a trend in standard deviation strongly influences the time -dependent upper quantiles. The uncertainty associated with the extrapolation of the trend makes it necessary to apply a relationship for trend which has time derivative tending to zero, e.g. we can assume a new climate equilibrium epoch approaching, or a time horizon is limited by the validity of the trend model. For both winter and summer SM time series, at least three distributions functions with trend model in the location, scale and shape parameters are estimated by means of the GAMLSS package using the ML-techniques. The resulting trend estimates in mean and standard deviation are mutually compared to the observed trends. Then, using AIC measures as weights, a multi-model distribution is constructed for each of two seasons separately. Further, assuming a mutual independence of the seasonal maxima, an AM model with time-dependent parameters can be obtained. The use of a multi-model approach can alleviate the effects of different and often contradictory trends obtained by using and identifying

  15. Vertically transmitted HPV-dependent squamous cell carcinoma of the external auditory canal. Case report of a child

    Energy Technology Data Exchange (ETDEWEB)

    Snietura, Miroslaw; Pakulo, Slawomir; Kopec, Agnieszka; Piglowski, Wojciech; Stanek-Widera, Agata [Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Tumor Pathology Department, Gliwice (Poland); Chelmecka-Wiktorczyk, Liliana [University Children' s Hospital of Cracow, Department of Oncology and Hematology, Cracow (Poland); Drabik, Grazyna [University Children' s Hospital of Cracow, Pathology Department, Cracow (Poland); Kosowski, Bogdan [NZOZ Prosmed, Cracow (Poland); Wyrobek, Lukasz [University Children' s Hospital of Cracow, Department of Radiology, Cracow (Poland); Balwierz, Walentyna [University Children' s Hospital of Cracow, Department of Oncology and Hematology, Cracow (Poland); Jagiellonian University in Cracow, Clinic of Oncology and Hematology, Polish-American Pediatric Institute, Cracow (Poland)

    2017-02-15

    There is much evidence that high-risk human papillomavirus (HPV) plays a causative role in a subset of head and neck squamous cell cancer (HNSCC) in adults. HPV-positive tumors behave differently even in their response to treatment and are therefore a distinct subset. Both HPV-positive and HPV-negative tumors of the head and neck region are usually in the domain of adults and cases in children are rare; thus when a 2-year-old child was diagnosed with this cancer in the external auditory canal, an in-depth assessment of the tumor was considered necessary. A 2-year-old girl was born to a HPV-positive mother who was diagnosed with cervical cancer during pregnancy. The child was delivered by caesarean section and the mother died of her cancer 7 months after delivery. After the diagnosis of locally invasive HPV-positive squamous cell cancer of the external auditory canal, the child was treated surgically, and with chemotherapy and radiotherapy. Full remission was obtained lasting up to 325 weeks since treatment was started, resulting in over 6 years of disease-free survival. This is the first case of advanced, HPV-related HNSCC in a 2-year-old child, in whom the tumor was located in the external auditory canal and who made a dramatic recovery after treatment with nonradical surgery, chemotherapy and radiotherapy. The child has currently been disease free for 6 years. This case supports the observation that HPV-related HNSCC tumors appear to respond favorably to treatment despite the patient's young age and the clinically advanced stage of the tumor. (orig.) [German] Es gibt reichlich Belege dafuer, dass das menschliche Papillomavirus vom Hochrisikotyp (HR-HPV) in einigen Faellen von Plattenepithelkarzinomen des Kopf- und Halsbereichs (HNSCC) eine Schluesselrolle spielt. HPV-positive Tumoren verhalten sich anders, auch bezueglich des Ansprechens auf die Behandlung. Deswegen stellen sie eine separate biologische Gruppe dar. Sowohl HPV-positive als auch HPV

  16. The Word Composite Effect Depends on Abstract Lexical Representations But Not Surface Features Like Case and Font

    Science.gov (United States)

    Ventura, Paulo; Fernandes, Tânia; Leite, Isabel; Almeida, Vítor B.; Casqueiro, Inês; Wong, Alan C.-N.

    2017-01-01

    Prior studies have shown that words show a composite effect: When readers perform a same-different matching task on a target-part of a word, performance is affected by the irrelevant part, whose influence is severely reduced when the two parts are misaligned. However, the locus of this word composite effect is largely unknown. To enlighten it, in two experiments, Portuguese readers performed the composite task on letter strings: in Experiment 1, in written words varying in surface features (between-participants: courier, notera, alternating-cAsE), and in Experiment 2 in pseudowords. The word composite effect, signaled by a significant interaction between alignment of the two word parts and congruence between parts was found in the three conditions of Experiment 1, being unaffected by NoVeLtY of the configuration or by handwritten form. This effect seems to have a lexical locus, given that in Experiment 2 only the main effect of congruence between parts was significant and was not modulated by alignment. Indeed, the cross-experiment analysis showed that words presented stronger congruence effects than pseudowords only in the aligned condition, because when misaligned the whole lexical item configuration was disrupted. Therefore, the word composite effect strongly depends on abstract lexical representations, as it is unaffected by surface features and is specific to lexical items. PMID:28676783

  17. Agency over a phantom limb and electromyographic activity on the stump depend on visuomotor synchrony: a case study

    Directory of Open Access Journals (Sweden)

    Shu eImaizumi

    2014-07-01

    Full Text Available Most patients, post-amputation, report the experience of a phantom limb. Some even sense voluntary movements when viewing a mirror image of the intact limb superimposed onto the phantom limb. While delayed visual feedback of an action is known to reduce a sense of agency, the effect of delayed visual feedback on phantom motor sensation (i.e., sense of controlling a phantom limb has not been examined. Using a video-projection system, we examined the effect of delayed visual feedback on phantom motor sensation in an upper-limb amputee (male; left upper-limb amputation. He was instructed to view mirrored video images of his intact hand clasping and unclasping during a phantom limb movement. He then rated the intensity of the phantom motor sensation. Three types of hand movement images were presented as follows: synchronous, asynchronous with a 250-ms delay, and asynchronous with a 500-ms delay. Results showed that phantom motor sensation decreased when the image was delayed by 250 and 500 ms. However, when we instructed the patient to adjust the phase of phantom limb movement to that of the image with a 500-ms delay, phantom motor sensation increased. There was also a positive correlation between intensity of phantom motor sensation and electromyographic activity on deltoids at the patient’s stump. These results suggest that phantom motor sensation and electromyographic activity on the stump depend on visuomotor synchrony and top-down effects.

  18. New Lagrangian tools for describing transport in aperiodic time dependent flows: a case study of the Kuroshio current

    Science.gov (United States)

    Mancho, Ana M.; Mendoza, Carolina

    2009-11-01

    In recent years there has been a lot of progress in the application of dynamical systems concepts to the description of transport in oceanic flows. In these flows the classical dynamical system theory does not apply since they are aperiodic and finite-time defined. Recently, for describing these flows a new definition of distinguished trajectory has been proposed (Madrid & Mancho, Chaos, 2009). Distinguished trajectories act as organizing centres of the geometrical template of aperiodic time-dependent flows, like fixed points and periodic orbits do in time independent or periodic flows. The computation of distinguished trajectories makes use of a function M of which we show contains a lot of Lagrangian information. In this presentation I will discuss how the visualization of this function M, allows identifying relevant Lagrangian features at a glance. In particular we report an application to real altimetry data taken from satellite in the area of the Kuroshio current. The function M also determines the stable and unstable subspaces of the distinguished hyperbolic trajectories which are tangent to the invariant manifolds. From the computation of stable and unstable manifolds we report an accurate description of transport routes in this region.

  19. Agency over a phantom limb and electromyographic activity on the stump depend on visuomotor synchrony: a case study.

    Science.gov (United States)

    Imaizumi, Shu; Asai, Tomohisa; Kanayama, Noriaki; Kawamura, Mitsuru; Koyama, Shinichi

    2014-01-01

    Most patients, post-amputation, report the experience of a phantom limb. Some even sense voluntary movements when viewing a mirror image of the intact limb superimposed onto the phantom limb. While delayed visual feedback of an action is known to reduce a sense of agency, the effect of delayed visual feedback on phantom motor sensation (i.e., sense of controlling a phantom limb) has not been examined. Using a video-projection system, we examined the effect of delayed visual feedback on phantom motor sensation in an upper-limb amputee (male; left upper-limb amputation). He was instructed to view mirrored video images of his intact hand clasping and unclasping during a phantom limb movement. He then rated the intensity of the phantom motor sensation. Three types of hand movement images were presented as follows: synchronous, asynchronous with a 250-ms delay, and asynchronous with a 500-ms delay. Results showed that phantom motor sensation decreased when the image was delayed by 250 and 500 ms. However, when we instructed the patient to adjust the phase of phantom limb movement to that of the image with a 500-ms delay, phantom motor sensation increased. There was also a positive correlation between intensity of phantom motor sensation and electromyographic (EMG) activity on deltoids at the patient's stump. These results suggest that phantom motor sensation and EMG activity on the stump depend on visuomotor synchrony and top-down effects.

  20. Community-Based Tourism - Option for Forest-Dependent Communities in 1A IUCN Protected Areas? Cameroon Case Study

    Directory of Open Access Journals (Sweden)

    Burgin Shelley

    2014-01-01

    Full Text Available In developing countries, ‘exponential’ growth in IUCN protected lands has occurred in the last 25 years. Approximately 6% of protected areas are ‘Strict Nature Reserve[s]’ (1A with emphasis on conservation and strict restrictions on human access. Before Bakossi Forest Reserve (Cameroon had 1A protection, 95% of local families used the Reserve for their livelihood. They farmed cash crops, collected fire wood, timber, and food with incomes equivalent to US$35,000/annually/family. Post-protection, the Reserve’s local communities lacked support to develop alternative livelihoods, and 75% reported being intercepted illegally trespassing by Reserve guards. Without illegal activity economic impacts would have been substantially greater. Protection has also meant foregone national income from timber and coffee exports. We used Bakossi Forest Reserve as a case study to identify issues facing local communities excluded from the Reserve that traditionally provided their livelihood. We also investigated potential alternative family livelihoods based on critical evaluation of the literature. We identified ‘exceptional’ community-based tourism potential. We also found that Cameroon was the first African country to develop community-based forestry with the dual roles of conservation and poverty alleviation. Using this model, community-based tourism could be a cost-effectively initiative to deliver the same dual roles as community-based forestry.

  1. Use of geochemical and isotope tracers to assess groundwater dependency of a terrestrial ecosystem: case study from southern Poland

    Science.gov (United States)

    Zurek, Anna J.; Witczak, Stanislaw; Kania, Jaroslaw; Rozanski, Kazimierz; Dulinski, Marek; Wachniew, Przemyslaw

    2015-04-01

    The presented study was aimed at better understanding of the functioning of groundwater dependent terrestrial ecosystem (GDTE) located in the south of Poland. The studied GDTE consists of a valuable forest stand (Niepolomice Forest) and associated wetland (Wielkie Bloto fen). It relies not only on shallow, unconfined aquifer but indirectly also on groundwater originating from the deeper confined aquifer, underlying the Quaternary cover and separated from it by an aquitard of variable thickness. The main objective of the study was to evaluate the contribution of groundwater to the water balance of the studied GDTE and thereby assess the potential risk to this system associated with intense exploitation of the deeper aquifer. The Wielkie Błoto fen area and the adjacent parts of Niepolomice Forest are drained by the Dluga Woda stream with 8.2 km2 of gauged catchment area. Hydrometric measurements, carried out on the Dluga Woda stream over two-year period (August 2011 - August 2013) were supplemented by chemical and isotope analyses of stream water, monitored on monthly basis. Physico-chemical parameters of the stream water (SEC, pH, Na content, Na/Cl molar ratio) and isotope tracers (deuterium, oxygen-18 and tritium) were used to quantify the expected contribution of groundwater seepage from the deeper aquifer to the water balance of the Dluga Woda catchment. The mean transit time of water through the catchment, derived from temporal variations of δ18O and tritium content in the Dluga Woda stream, was in the order of three months. This fast component of the total discharge of Dluga Woda stream is associated surface runoff and groundwater flow paths through the Quaternary cover. The slow component devoid of tritium and probably originated from the deeper Neogene aquifer is equal to approximately 30% of the total discharge. The relationships between the physico-chemical parameters of the stream water and the flow rate of Dluga Woda clearly indicate that the monitored

  2. Chronic subdural hematoma in elderly patient with EDTA-dependent pseudothrombocytopenia recently treated with aspirin and warfarin: case report.

    Science.gov (United States)

    Tosa, Masato; Fujita, Hiroshi; Ishihama, Yumiko; Nishimura, Shigeko; Ide, Takafumi

    2014-01-01

    A 78-year-old man who had a history of myocardial and cerebral infarction and who was treated with aspirin and warfarin, presented with left chronic subdural hematoma. Cerebral computed tomography showed severe brain compression of hematoma with midline shift, indicating the need for emergent surgery. The hematology and clotting tests upon admission revealed severe thrombocytopenia (platelet count, 1.3 × 10(4)/μL) with normal clotting activity. Because platelet aggregation was evident in the smear, we re-examined the patient for hematology using tubes that contained heparin, showing also low platelet count (2.3 × 10(4)/μL). The day on admission, we performed irrigation and drainage of the chronic subdural hematoma through single burr-hole craniostomy. During surgery, we used 10 units of platelet concentrates (PCs) for the reason that the patient was taking aspirin and coagulopathy derived from low platelet count could not be excluded. After surgery, we re-evaluated the hematology of the blood stored in tubes that contained ethylenediaminetetraacetic acid (EDTA) with or without kanamycin (KM). Treatment with KM dissociated EDTA-induced platelet aggregation and revealed platelet counts with highest accuracy (no KM treatment, 1.3 × 10(4)/μL; KM treatment, 15.2 × 10(4)/μL). This phenomenon is called EDTA-Dependent Pseudothrombocytopenia (PTCP) defined as falsely low platelet counts reported by automated hematology analyzers due to platelet aggretgation. Awareness of the phenomenon will enable neurosurgeons to manage patients with PTCP appropriately and clinical laboratory especially in emergency hospital is recommended to prepare for the hematological tubes being added KM in routine analysis, resulting in preventing mistaken diagnosis.

  3. Fit-for-purpose: species distribution model performance depends on evaluation criteria - Dutch Hoverflies as a case study.

    Science.gov (United States)

    Aguirre-Gutiérrez, Jesús; Carvalheiro, Luísa G; Polce, Chiara; van Loon, E Emiel; Raes, Niels; Reemer, Menno; Biesmeijer, Jacobus C

    2013-01-01

    Understanding species distributions and the factors limiting them is an important topic in ecology and conservation, including in nature reserve selection and predicting climate change impacts. While Species Distribution Models (SDM) are the main tool used for these purposes, choosing the best SDM algorithm is not straightforward as these are plentiful and can be applied in many different ways. SDM are used mainly to gain insight in 1) overall species distributions, 2) their past-present-future probability of occurrence and/or 3) to understand their ecological niche limits (also referred to as ecological niche modelling). The fact that these three aims may require different models and outputs is, however, rarely considered and has not been evaluated consistently. Here we use data from a systematically sampled set of species occurrences to specifically test the performance of Species Distribution Models across several commonly used algorithms. Species range in distribution patterns from rare to common and from local to widespread. We compare overall model fit (representing species distribution), the accuracy of the predictions at multiple spatial scales, and the consistency in selection of environmental correlations all across multiple modelling runs. As expected, the choice of modelling algorithm determines model outcome. However, model quality depends not only on the algorithm, but also on the measure of model fit used and the scale at which it is used. Although model fit was higher for the consensus approach and Maxent, Maxent and GAM models were more consistent in estimating local occurrence, while RF and GBM showed higher consistency in environmental variables selection. Model outcomes diverged more for narrowly distributed species than for widespread species. We suggest that matching study aims with modelling approach is essential in Species Distribution Models, and provide suggestions how to do this for different modelling aims and species' data

  4. Birth outcomes of cases with unclassified multiple congenital abnormalities and pregnancy complications in their mothers depending on the number of component defects. Population-based case-control study.

    Science.gov (United States)

    Puhó, Erzsébet H; Czeizel, Andrew E; Acs, Nándor; Bánhidy, Ferenc

    2008-09-01

    Multiple congenital abnormalities (MCA) represent the most severe category of structural birth defects, (i.e. congenital abnormalities [CA]). Unfortunately, most MCA are not recognized and/or identified as MCA syndromes or MCA associations in the clinical practice. The term unclassified MCA (UMCA) is used for this category of MCA. We decided to evaluate the component CA of UMCA cases. The population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities (1980-1996) was evaluated. 'False' MCA, such as complex CA, polytopic field defects and sequences were excluded from the category of MCA. In addition, MCA syndromes caused by chromosomal aberrations and major mutant genes with preconceptional origin were excluded from the dataset of the Surveillance. MCA syndromes caused by teratogens and MCA associations with well-defined component CA were also excluded in the study. Thus, only UMCA cases (i) without the recognition of previously delineated MCA syndromes (ii) and/or without the identification of new MCA syndromes or (iii) caused by random combination of CA were included in the study. We compared data from 1349 cases with UMCA, 2405 matched population controls without any CA, and 21 494 malformed controls with isolated CA. There was a higher rate of stillbirth and a moderate male excess in UMCA cases, a somewhat shorter gestational age at delivery and an obvious reduction in birthweight. The intrauterine fetal growth retardation and rate of low-birthweight newborns showed an association with the number of component CA in UMCA cases. A similar association was not found with gestational age and the rate of preterm birth. UMCA represent one of the most severe categories of CA. The degree of intrauterine fetal growth retardation depends on number of component CA in UMCA cases.

  5. Original article Determinants of personality in the scope of motivation for maintaining abstinence in the case of male alcohol-dependent individuals concluding therapy

    Directory of Open Access Journals (Sweden)

    Jan Chodkiewicz

    2014-12-01

    Full Text Available Background The results of numerous studies indicate strong associations of personality with the occurrence, and also with the treatment, of alcohol dependence. However, there is no agreement regarding the role of particular dimensions of temperament and character in the course of, and for the results of, alcohol rehabilitation therapy. The objective of the present research was to investigate the relationships between the dimensions of temperament and character as they are presented by Robert Cloninger and motivation for maintaining abstinence in the case of male alcohol-dependent individuals concluding the therapy. Participants and procedure Eighty-nine male alcohol-dependent individuals, concluding alcohol rehabilitation therapy in an outpatient setting, were studied. The following research tools were applied: the Temperament and Character Inventory (TCI of R. Clo­ninger in the Polish adaptation of E. Hornowska (2003, and the Motivation for Maintaining Abstinence Inventory, the author of which is M. Ziółkowski. Results Two clusters, differing in the aspect of motivation for maintaining abstinence after the conclusion of the treatment, were distinguished: of individuals manifesting weaker motivation (n = 39 and those manifesting stronger motivation (n = 50. The patients with stronger motivation manifested the following major features: a lower level of harm avoidance, a higher level of reward dependence, and a higher level of cooperativeness. Conclusions Personality as it is presented by Cloninger manifests connections with motivation for maintaining abstinence. The research confirms the need for diagnosing addicted patients in the scope of temperament and character traits.

  6. Derivation of a Provisional, Age-dependent, AIS2+ Thoracic Risk Curve for the THOR50 Test Dummy via Integration of NASS Cases, PMHS Tests, and Simulation Data.

    Science.gov (United States)

    Laituri, Tony R; Henry, Scott; El-Jawahri, Raed; Muralidharan, Nirmal; Li, Guosong; Nutt, Marvin

    2015-11-01

    A provisional, age-dependent thoracic risk equation (or, "risk curve") was derived to estimate moderate-to-fatal injury potential (AIS2+), pertaining to men with responses gaged by the advanced mid-sized male test dummy (THOR50). The derivation involved two distinct data sources: cases from real-world crashes (e.g., the National Automotive Sampling System, NASS) and cases involving post-mortem human subjects (PMHS). The derivation was therefore more comprehensive, as NASS datasets generally skew towards younger occupants, and PMHS datasets generally skew towards older occupants. However, known deficiencies had to be addressed (e.g., the NASS cases had unknown stimuli, and the PMHS tests required transformation of known stimuli into THOR50 stimuli). For the NASS portion of the analysis, chest-injury outcomes for adult male drivers about the size of the THOR50 were collected from real-world, 11-1 o'clock, full-engagement frontal crashes (NASS, 1995-2012 calendar years, 1985-2012 model-year light passenger vehicles). The screening for THOR50-sized men involved application of a set of newly-derived "correction" equations for self-reported height and weight data in NASS. Finally, THOR50 stimuli were estimated via field simulations involving attendant representative restraint systems, and those stimuli were then assigned to corresponding NASS cases (n=508). For the PMHS portion of the analysis, simulation-based closure equations were developed to convert PMHS stimuli into THOR50 stimuli. Specifically, closure equations were derived for the four measurement locations on the THOR50 chest by cross-correlating the results of matched-loading simulations between the test dummy and the age-dependent, Ford Human Body Model. The resulting closure equations demonstrated acceptable fidelity (n=75 matched simulations, R2≥0.99). These equations were applied to the THOR50-sized men in the PMHS dataset (n=20). The NASS and PMHS datasets were combined and subjected to survival

  7. A case report on the treatment of complex chronic pain and opioid dependence by a multidisciplinary transitional pain service using the ACT Matrix and buprenorphine/naloxone

    Science.gov (United States)

    Weinrib, Aliza Z; Burns, Lindsay C; Mu, Alex; Azam, Muhammad Abid; Ladak, Salima SJ; McRae, Karen; Katznelson, Rita; Azargive, Saam; Tran, Cieran; Katz, Joel; Clarke, Hance

    2017-01-01

    In an era of growing concern about opioid prescribing, the postsurgical period remains a critical window with the risk of significant opioid dose escalation, particularly in patients with a history of chronic pain and presurgical opioid use. The purpose of this case report is to describe the multidisciplinary care of a complex, postsurgical pain patient by an innovative transitional pain service (TPS). A 59-year-old male with complex chronic pain, as well as escalating long-term opioid use, presented with a bleeding duodenal ulcer requiring emergency surgery. After surgery, the TPS provided integrated pharmacological and behavioral treatment, including buprenorphine combined with naloxone and acceptance and commitment therapy (ACT) using the ACT Matrix. The result was dramatic pain reduction and improved functioning and quality of life after 40+ years of chronic pain, thus changing the pain trajectory of a chronic, complex, opioid-dependent patient.

  8. Evidence of a cold immunoglobulin M autoantibody against 78-kD platelet glycoprotein in a case of EDTA-dependent pseudothrombocytopenia.

    Science.gov (United States)

    De Caterina, M; Fratellanza, G; Grimaldi, E; Varriale, V; Scopacasa, F; Di Maro, G; Formisano, S

    1993-02-01

    Pseudothrombocytopenia is a phenomenon in which the electronic count shows spuriously low platelet counts in subjects with normal platelet levels. The mechanism of anticoagulant-dependent pseudothrombocytopenia appears to involve cold reactive agglutinins against platelet antigens. The authors report a case of EDTA-dependent pseudothrombocytopenia with evidence of a cold immunoglobulin M antibody against 78-kD platelet membrane glycoprotein (GP). Cell counts were performed by Coulter Counter S-Plus VI (Coulter, Hialeah, FL) in the following anticoagulants: EDTA, Na-citrate, and citrate-theophylline-adenosine-dipyridamole. Anti-platelet antibodies and platelet membrane GP antigens were assayed by an immunofluorescence technique as described by Van dem Borne in 1978. An immunoglobulin M/lambda anti-platelet antibody was found to react in serum as well as in plasma EDTA at room temperature, but not at 37 degrees C. This antibody appeared to be directed against GP78 membrane antigen because this antigen was not detectable by immunofluorescence in platelets collected in EDTA and Na-citrate anticoagulant, whereas a fluorescence signal was revealed in platelets collected in citrate-theophylline-adenosine-dipyridamole. This evidence was confirmed by platelet clumping inhibition tests in which target platelets were pretreated with anti-GP monoclonal antibodies. Clumping in the presence of pseudothrombocytopenia serum was inhibited by anti-GP78kD and anti-GPIIb/IIIa but not by anti-Ib. In this case, GP78 appears to be involved in platelet clumping, together with IIb/IIIa complex. The partial inhibition of the phenomenon observed in citrate-theophylline-adenosine-dipyridamole is probably related to a lower expression of the membrane antigens in platelets collected in this anticoagulant.

  9. A case report on the treatment of complex chronic pain and opioid dependence by a multidisciplinary transitional pain service using the ACT Matrix and buprenorphine/naloxone

    Directory of Open Access Journals (Sweden)

    Weinrib AZ

    2017-03-01

    Full Text Available Aliza Z Weinrib,1,2 Lindsay C Burns,1,2 Alex Mu,1 Muhammad Abid Azam,1,2 Salima SJ Ladak,1 Karen McRae,1,3 Rita Katznelson,1,3 Saam Azargive,1 Cieran Tran,1 Joel Katz,1–3 Hance Clarke1,3 1Pain Research Unit, Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, 2Department of Psychology, York University, 3Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada Abstract: In an era of growing concern about opioid prescribing, the postsurgical period remains a critical window with the risk of significant opioid dose escalation, particularly in patients with a history of chronic pain and presurgical opioid use. The purpose of this case report is to describe the multidisciplinary care of a complex, postsurgical pain patient by an innovative transitional pain service (TPS. A 59-year-old male with complex chronic pain, as well as escalating long-term opioid use, presented with a bleeding duodenal ulcer requiring emergency surgery. After surgery, the TPS provided integrated pharmacological and behavioral treatment, including buprenorphine combined with naloxone and acceptance and commitment therapy (ACT using the ACT Matrix. The result was dramatic pain reduction and improved functioning and quality of life after 40+ years of chronic pain, thus changing the pain trajectory of a chronic, complex, opioid-dependent patient. Keywords: transitional pain service, postsurgical pain, chronic pain, opioid dependence, opioid weaning, acceptance and commitment therapy

  10. Pyridoxine-dependent seizures: long-term follow-up of two cases with clinical and MRI findings, and pyridoxine treatment.

    Science.gov (United States)

    Ulvi, Hizir; Müngen, Bülent; Yakinci, Cengiz; Yoldaş, Tahir

    2002-10-01

    Pyridoxine-dependency is a rare autosomal recessive disorder causing a severe seizure disorder of neonatal onset. There are a few reports including neuroimaging studies, such as cranial CT and MRI, and one report with longitudinal MRI findings in two cases with pyridoxine-dependent seizures (PDS). We report long-term follow-up of two siblngs with PDS in the light of clinical, EEG, CT and MRI findings, and pyridoxine treatment. The first patient, an 8-year-old female who had neonatal seizures, has sequential cranial CT and MRIs which are normal except for mega cistema magna thus far. She still has mild mental retardation, although the accurate diagnosis was made when she was 6 years old and pyridoxine treatment was initiated. The second patient, a 1-year-old female, who is the younger sibling of the first patient, presented with neonatal seizures and PDS was diagnosed immediately, with resulting pyridoxine treatment (10 mg/kg/day). She is now neurologically normal, seizure-free, and has sequential normal CT and MRIs. These patients show rather benign clinical courses.

  11. A Case Control Study on School Dropouts in Children of Alcohol-Dependent Males Versus that in Abstainers/Social Drinkers′ Children

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    Violet N Pinto

    2012-01-01

    Full Text Available Objective: To study and compare in the children of alcohol-dependent males versus those in a socio-demographically similar control group, the occurrence of school dropouts, and to examine the link between certain factors like parental education and socioeconomic status on school dropout. Materials and Methods: This was a community-based case control study. The participants were 107 family units in both study group (alcohol-dependent male, wife, at least one child less than 14 years of age and control group (abstainer/social drinker, wife, at least one child less than 14 years of age. It was conducted in an urban slum community in Mumbai. Interview technique was used for data collection. The study was conducted for a period of 1 year. Statistical Analysis: Using software SPSS version 17.0, percentages, Chi-square test. Results and Conclusion: The number of school dropouts was significantly higher (45.31%, P < 0.001 in the children of alcohol-dependent males as compared to 22.47% in the abstainers/social drinkers′ children. In the study group, there was higher number of school dropouts among boys (52.73%, P < 0.05 as compared to girls (35.37%. There was a statistically significant association between parental illiteracy and school dropout in children in both the groups. In the control group, significantly higher number of school dropouts of socioeconomic class IV and V had dropped out as compared to those of socioeconomic class III and II.

  12. Impact of High-Cut-Off Dialysis on Renal Recovery in Dialysis-Dependent Multiple Myeloma Patients: Results from a Case-Control Study.

    Directory of Open Access Journals (Sweden)

    Hans U Gerth

    Full Text Available High-cut-off hemodialysis (HCO-HD can effectively reduce high concentrations of circulating serum free light chains (sFLC in patients with dialysis-dependent acute kidney injury (AKI due to multiple myeloma (MM. Therefore, the aim of this study was to analyze renal recovery in a retrospective single-center cohort of dialysis-dependent MM patients treated with either conventional HD (conv. HD or HCO-HD.The final cohort consisted of 59 patients treated with HCO-HD (n = 42 or conv. HD (n = 17. A sustained sFLC response was detected in a significantly higher proportion of HCO-HD patients (83.3% compared with conv. HD patients (29.4%; p = 0.007. The median duration of sFLC required to reach values <1000 mg/l was 14.5 days in the HCO-HD group and 36 days in the conv. HD group. The corresponding rates of renal recovery were 64.3% and 29.4%, respectively (chi-squared test, p = 0.014. Multivariate regression and decision tree analysis (recursive partitioning revealed HCO-HD (adjusted odds ratio [OR] 6.1 [95% confidence interval (CI 1.5-24.5], p = 0.011 and low initial uric acid values (adjusted OR 1.3 [95%CI 1.0-1.7], p = 0.045 as independent and paramount variables associated with a favorable renal outcome.In summary, the results from this retrospective case-control study suggest in addition to novel agent-based chemotherapy a benefit of HCO-HD in sFLC removal and renal outcome in dialysis-dependent AKI secondary to MM. This finding was especially pertinent in patients with low initial uric acid values, resulting in a promising renal recovery rate of 71.9%. Further prospective studies are warranted.

  13. How temperature-dependent elasticity alters host rock/magmatic reservoir models: A case study on the effects of ice-cap unloading on shallow volcanic systems

    Science.gov (United States)

    Bakker, Richard R.; Frehner, Marcel; Lupi, Matteo

    2016-12-01

    In geodynamic numerical models of volcanic systems, the volcanic basement hosting the magmatic reservoir is often assumed to exhibit constant elastic parameters with a sharp transition from the host rocks to the magmatic reservoir. We assess this assumption by deriving an empirical relation between elastic parameters and temperature for Icelandic basalts by conducting a set of triaxial compression experiments between 200 °C and 1000 °C. Results show a significant decrease of Young's modulus from ∼38 GPa to less than 4.7 GPa at around 1000 °C. Based on these laboratory data, we develop a 2D axisymmetric finite-element model including temperature-dependent elastic properties of the volcanic basement. As a case study, we use the Snæfellsjökull volcanic system, Western Iceland to evaluate pressure differences in the volcanic edifice and basement due to glacial unloading of the volcano. First, we calculate the temperature field throughout the model and assign elastic properties accordingly. Then we assess unloading-driven pressure differences in the magma chamber at various depths in models with and without temperature-dependent elastic parameters. With constant elastic parameters and a sharp transition between basement and magma chamber we obtain results comparable to other studies. However, pressure changes due to surface unloading become smaller when using more realistic temperature-dependent elastic properties. We ascribe this subdued effect to a transition zone around the magma chamber, which is still solid rock but with relatively low Young's modulus due to high temperatures. We discuss our findings in the light of volcanic processes in proximity to the magma chamber, such as roof collapse, dyke injection, or deep hydrothermal circulation. Our results aim at quantifying the effects of glacial unloading on magma chamber dynamics and volcanic activity.

  14. Nicotine Dependence

    Science.gov (United States)

    Nicotine dependence Overview By Mayo Clinic Staff Nicotine dependence ― also called tobacco dependence ― is an addiction to tobacco products caused by the drug nicotine. Nicotine dependence means you can't stop using the substance, ...

  15. Comorbidades entre dependência química, distimia, HIV e HCV: relato de caso Comorbidity between addiction, dysthymia, HIV and HCV: case report

    Directory of Open Access Journals (Sweden)

    Vanessa Fabiane Machado Gomes Marsden

    2009-01-01

    , contribute to mental status deterioration and the treatment for such conditions can cause fluctuations on mood. CASE REPORT: A 40 years old patient with comorbidity between chemical dependence (heroin and alcohol and dysthymia, complicated by relapses, IV drug use and serological status positive to HIV-1 and HCV. CONCLUSION: Addiction patients with psychiatric and infectious comorbidity are challenging to diagnose, treat and define therapeutical approaches to the different conditions. Proper clinical investigation and approach leads to benefits in health quality and potential financial benefits.

  16. Regarding the use and misuse of retinal protonated Schiff base photochemistry as a test case for time-dependent density-functional theory

    Energy Technology Data Exchange (ETDEWEB)

    Valsson, Omar [Department of Chemistry and Applied Biosciences, ETH Zurich and Facoltà di Informatica, Instituto di Scienze Computationali, Università della Svizzera italiana, Via Giuseppe Buffi 13, CH-6900 Lugano (Switzerland); Filippi, Claudia, E-mail: c.filippi@utwente.nl [MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede (Netherlands); Casida, Mark E., E-mail: mark.casida@ujf-grenoble.fr [Laboratoire de Chimie Théorique, Département de Chimie Moléculaire (DCM), Institut de Chimie Moléculaire de Grenoble (ICMG), Université Joseph Fourier, Grenoble I, F-3801 Grenoble (France)

    2015-04-14

    The excited-state relaxation of retinal protonated Schiff bases (PSBs) is an important test case for biological applications of time-dependent (TD) density-functional theory (DFT). While well-known shortcomings of approximate TD-DFT might seem discouraging for application to PSB relaxation, progress continues to be made in the development of new functionals and of criteria allowing problematic excitations to be identified within the framework of TD-DFT itself. Furthermore, experimental and theoretical ab initio advances have recently lead to a revised understanding of retinal PSB photochemistry, calling for a reappraisal of the performance of TD-DFT in describing this prototypical photoactive system. Here, we re-investigate the performance of functionals in (TD-)DFT calculations in light of these new benchmark results, which we extend to larger PSB models. We focus on the ability of the functionals to describe primarily the early skeletal relaxation of the chromophore and investigate how far along the out-of-plane pathways these functionals are able to describe the subsequent rotation around formal single and double bonds. Conventional global hybrid and range-separated hybrid functionals are investigated as the presence of Hartree-Fock exchange reduces problems with charge-transfer excitations as determined by the Peach-Benfield-Helgaker-Tozer Λ criterion and by comparison with multi-reference perturbation theory results. While we confirm that most functionals cannot render the complex photobehavior of the retinal PSB, do we also observe that LC-BLYP gives the best description of the initial part of the photoreaction.

  17. Regarding the use and misuse of retinal protonated Schiff base photochemistry as a test case for time-dependent density-functional theory

    Science.gov (United States)

    Valsson, Omar; Filippi, Claudia; Casida, Mark E.

    2015-04-01

    The excited-state relaxation of retinal protonated Schiff bases (PSBs) is an important test case for biological applications of time-dependent (TD) density-functional theory (DFT). While well-known shortcomings of approximate TD-DFT might seem discouraging for application to PSB relaxation, progress continues to be made in the development of new functionals and of criteria allowing problematic excitations to be identified within the framework of TD-DFT itself. Furthermore, experimental and theoretical ab initio advances have recently lead to a revised understanding of retinal PSB photochemistry, calling for a reappraisal of the performance of TD-DFT in describing this prototypical photoactive system. Here, we re-investigate the performance of functionals in (TD-)DFT calculations in light of these new benchmark results, which we extend to larger PSB models. We focus on the ability of the functionals to describe primarily the early skeletal relaxation of the chromophore and investigate how far along the out-of-plane pathways these functionals are able to describe the subsequent rotation around formal single and double bonds. Conventional global hybrid and range-separated hybrid functionals are investigated as the presence of Hartree-Fock exchange reduces problems with charge-transfer excitations as determined by the Peach-Benfield-Helgaker-Tozer Λ criterion and by comparison with multi-reference perturbation theory results. While we confirm that most functionals cannot render the complex photobehavior of the retinal PSB, do we also observe that LC-BLYP gives the best description of the initial part of the photoreaction.

  18. A prospective nested case-control study of Dengue in infants: rethinking and refining the antibody-dependent enhancement dengue hemorrhagic fever model.

    Directory of Open Access Journals (Sweden)

    Daniel H Libraty

    2009-10-01

    Full Text Available Dengue hemorrhagic fever (DHF is the severe and life-threatening syndrome that can develop after infection with any one of the four dengue virus (DENV serotypes. DHF occurs almost exclusively in individuals with secondary heterologous DENV infections and infants with primary DENV infections born to dengue immune mothers. The widely accepted explanation for the pathogenesis of DHF in these settings, particularly during infancy, is antibody-dependent enhancement (ADE of DENV infection.We conducted a prospective nested case-control study of DENV infections during infancy. Clinical data and blood samples were collected from 4,441 mothers and infants in up to two pre-illness study visits, and surveillance was performed for symptomatic and inapparent DENV infections. Pre-illness plasma samples were used to measure the associations between maternally derived anti-DENV3 antibody-neutralizing and -enhancing capacities at the time of DENV3 infection and development of infant DHF. The study captured 60 infants with DENV infections across a wide spectrum of disease severity. DENV3 was the predominant serotype among the infants with symptomatic (35/40 and inapparent (15/20 DENV infections, and 59/60 infants had a primary DENV infection. The estimated in vitro anti-DENV3 neutralizing capacity at birth positively correlated with the age of symptomatic primary DENV3 illness in infants. At the time of symptomatic DENV3 infection, essentially all infants had low anti-DENV3 neutralizing activity (50% plaque reduction neutralizing titers [PRNT(50] 50 is associated with protection from symptomatic DENV3 illness. We did not find a significant association between DENV3 ADE activity at illness onset and the development of DHF compared with less severe symptomatic illness. The results of this study should encourage rethinking or refinement of the current ADE pathogenesis model for infant DHF and stimulate new directions of research into mechanisms responsible for the

  19. On the impedance of galvanic cells XVIII. The potential dependence of the faradaic impedance in the case of an irreversible electrode reaction, and its application to A.C. polarography

    NARCIS (Netherlands)

    Timmer, B.; Sluyters-Rehbach, M.; Sluyters, J.H.

    1967-01-01

    A theoretical treatment for the potential dependence of the faradaic impedance, in the case that the electrode reaction behaves irreversibly with respect to the direct current, using the steady-state concept, is presented. An analysis of the expressions obtained in the complex impedance plane is giv

  20. Comparative study of marital adjustment and life satisfaction among spouses of patients with alcohol dependence and normal healthy control: a case control study

    Directory of Open Access Journals (Sweden)

    Nazish Fatima

    2015-09-01

    Results: There was significant difference in respect to life satisfaction among the spouses of individual with alcohol dependence syndrome and normal healthy control. Life satisfaction as well as marital adjustment was better in spouses of normal healthy control as compared to spouses of patients of alcohol dependence. Conclusions: There is significant difference in respect to life satisfaction among the spouses of individual with alcohol dependence syndrome and normal healthy control. Wives of normal healthy control had better marital adjustment as compared to spouses of alcohol dependence syndrome. There was positive co-relation between life satisfaction and marital adjustment. [Int J Res Med Sci 2015; 3(9.000: 2246-2251

  1. Interactive Visualization of Dependencies

    Science.gov (United States)

    Moreno, Camilo Arango; Bischof, Walter F.; Hoover, H. James

    2012-01-01

    We present an interactive tool for browsing course requisites as a case study of dependency visualization. This tool uses multiple interactive visualizations to allow the user to explore the dependencies between courses. A usability study revealed that the proposed browser provides significant advantages over traditional methods, in terms of…

  2. Interactive Visualization of Dependencies

    Science.gov (United States)

    Moreno, Camilo Arango; Bischof, Walter F.; Hoover, H. James

    2012-01-01

    We present an interactive tool for browsing course requisites as a case study of dependency visualization. This tool uses multiple interactive visualizations to allow the user to explore the dependencies between courses. A usability study revealed that the proposed browser provides significant advantages over traditional methods, in terms of…

  3. Path Dependency

    OpenAIRE

    Mark Setterfield

    2015-01-01

    Path dependency is defined, and three different specific concepts of path dependency – cumulative causation, lock in, and hysteresis – are analyzed. The relationships between path dependency and equilibrium, and path dependency and fundamental uncertainty are also discussed. Finally, a typology of dynamical systems is developed to clarify these relationships.

  4. Estimated probability of becoming a case of drug dependence in relation to duration of drug-taking experience: a functional analysis approach.

    Science.gov (United States)

    Vsevolozhskaya, Olga A; Anthony, James C

    2016-06-29

    Measured as elapsed time from first use to dependence syndrome onset, the estimated "induction interval" for cocaine is thought to be short relative to the cannabis interval, but little is known about risk of becoming dependent during first months after onset of use. Virtually all published estimates for this facet of drug dependence epidemiology are from life histories elicited years after first use. To improve estimation, we turn to new month-wise data from nationally representative samples of newly incident drug users identified via probability sampling and confidential computer-assisted self-interviews for the United States National Surveys on Drug Use and Health, 2004-2013. Standardized modules assessed first and most recent use, and dependence syndromes, for each drug subtype. A four-parameter Hill function depicts the drug dependence transition for subgroups defined by units of elapsed time from first to most recent use, with an expectation of greater cocaine dependence transitions for cocaine versus cannabis. This study's novel estimates for cocaine users one month after first use show 2-4% with cocaine dependence; 12-17% are dependent when use has persisted. Corresponding cannabis estimates are 0-1% after one month, but 10-23% when use persists. Duration or persistence of cannabis smoking beyond an initial interval of a few months of use seems to be a signal of noteworthy risk for, or co-occurrence of, rapid-onset cannabis dependence, not too distant from cocaine estimates, when we sort newly incident users into subgroups defined by elapsed time from first to most recent use. Copyright © 2016 John Wiley & Sons, Ltd.

  5. Energy dependence and vulnerability: the brazilian case of natural gas; Dependencia e vulnerabilidade energetica: o caso do gas natural no Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Pinto Junior, Helder Queiroz

    2007-07-01

    This article emphasizes the remarkable traces of natural gas industry evolution highlighting the main factors which explain the growing rise of importation and the energy dependence during the last decade.

  6. Active dependency.

    Science.gov (United States)

    Bornstein, R F

    1995-02-01

    Although dependency has long been associated with passivity, weakness, and submissiveness, a review of the empirical literature reveals that, in certain situations and settings, dependent persons actually exhibit a variety of active, assertive behaviors. In this article, I: a) trace the historical roots of the dependency-passivity link; b) review empirical studies from developmental, social, and clinical psychology which indicate that, in certain circumstances, dependency is associated with active, assertive behavior on the part of the dependent person; c) offer an alternative conceptual model of dependency that accounts for the entire range of behaviors-both passive and active-that are exhibited by the dependent person; and d) discuss the diagnostic and therapeutic implications of this alternative conceptual model of dependency.

  7. Remarks on solving the one-dimensional time-dependent Schrödinger equation on the interval ?: the case of a quantum bouncer

    Science.gov (United States)

    Dembinski, S. T.; Wolniewicz, L.

    1996-01-01

    It is shown that the 1D Hamiltonian, which is a sum of operators which generate a finite nilpotent Lie algebra and depends explicitly on time existing closed form solutions of the time-dependent Schrödinger equation, cannot fulfil in general boundary and normalization conditions on a positive semi-axis. An explanation of the controversy surrounding the solutions of the quantum bouncer model, which appeared recently in the literature, is given.

  8. Cannabis-dependence risk relates to synergism between neuroticism and proenkephalin SNPs associated with amygdala gene expression: case-control study.

    Directory of Open Access Journals (Sweden)

    Didier Jutras-Aswad

    Full Text Available Many young people experiment with cannabis, yet only a subgroup progress to dependence suggesting individual differences that could relate to factors such as genetics and behavioral traits. Dopamine receptor D2 (DRD2 and proenkephalin (PENK genes have been implicated in animal studies with cannabis exposure. Whether polymorphisms of these genes are associated with cannabis dependence and related behavioral traits is unknown.Healthy young adults (18-27 years with cannabis dependence and without a dependence diagnosis were studied (N = 50/group in relation to a priori-determined single nucleotide polymorphisms (SNPs of the DRD2 and PENK genes. Negative affect, Impulsive Risk Taking and Neuroticism-Anxiety temperamental traits, positive and negative reward-learning performance and stop-signal reaction times were examined. The findings replicated the known association between the rs6277 DRD2 SNP and decisions associated with negative reinforcement outcomes. Moreover, PENK variants (rs2576573 and rs2609997 significantly related to Neuroticism and cannabis dependence. Cigarette smoking is common in cannabis users, but it was not associated to PENK SNPs as also validated in another cohort (N = 247 smokers, N = 312 non-smokers. Neuroticism mediated (15.3%-19.5% the genetic risk to cannabis dependence and interacted with risk SNPs, resulting in a 9-fold increase risk for cannabis dependence. Molecular characterization of the postmortem human brain in a different population revealed an association between PENK SNPs and PENK mRNA expression in the central amygdala nucleus emphasizing the functional relevance of the SNPs in a brain region strongly linked to negative affect.Overall, the findings suggest an important role for Neuroticism as an endophenotype linking PENK polymorphisms to cannabis-dependence vulnerability synergistically amplifying the apparent genetic risk.

  9. Remarks on solving the one-dimensional time-dependent Schroedinger equation on the interval [0, {infinity}]: the case of a quantum bouncer

    Energy Technology Data Exchange (ETDEWEB)

    Dembinski, S.T.; Wolniewicz, L. [Institute of Physics, Nicholas Copernicus University, Torun (Poland)

    1996-01-21

    It is shown that the 1 D Hamiltonian, which is a sum of operators which generate a finite nilpotent Lie algebra and depends explicitly on time existing closed form solutions of the time-dependent Schroedinger equation, cannot fulfil in general boundary and normalization conditions on a positive semi-axis. An explanation of the controversy surrounding the solutions of the quantum bouncer model, which appeared recently in the literature, is given. (author)

  10. Effects of long-term sustained naltrexone release onthe optic center in opioid-dependent patients Case-control study in four provinces of China

    Institute of Scientific and Technical Information of China (English)

    Shengxi He; Longchuan Yu; Shaowei Jia; Qing Chen; Dongmei Wang; Shu Hu

    2011-01-01

    Very little is known about visual functional recovery following long-term naltrexone administration in opioid-dependent patients. In the present study, a portable event-related potential (ERP) working system was utilized to collect and record ERP in opioid-dependent patients and normal controls in visual half-field testing. In addition, the influence of long-term sustained naltrexone release on the visual nervous system was observed in opioid-dependent patients. Results revealed a significant main group effect in reaction time to visual signal stimulations. The reaction time of normal controls was shortest, but longest in opioid-dependent patients. The reaction time of long-term sustained naltrexone release group and compulsory detoxification group was similar to normal controls. A significant main group effect was also observed in P100 latency, and P100 latency in normal controls and the compulsory detoxification group was significantly decreased compared with the opioid-dependent patients. P100 amplitude at the Oz-electrode resulted in a significant main group effect. In particular, normal controls exhibited significant differences compared with long-term sustained release naltrexone and compulsory detoxification groups. These findings demonstrated that long-term sustained naltrexone release effectively ameliorated optic center function and improved visual sensitivity and reactions in opioid-dependent patients.

  11. Surveying the relationship of Internet addiction with dependence on cell phone, depression, anxiety, and stress in collegians (Case study: Bam University of Medical Sciences

    Directory of Open Access Journals (Sweden)

    Asra Nassehi

    2016-06-01

    Full Text Available Background and objectives: A considerable increase in using the Internet and cell phone is evident especially among university students. On the other hand, the attention and concerns expressed about the psychological and social effects of long-term use of communicational technologies and the, probably negative, effects on professional future and social relationships are growing. Therefore, the present study is aimed at determining the relationship of Internet addiction with excessive dependence on cell phone, depression, anxiety, and stress in the students of Bam University of Medical Sciences. Methodology: A comparative-correlative study on 230 students in Bam University of Medical Sciences was carried out in 2014. The data was collected using Young’s Internet Addiction Test (IAT, dependence of cell phone, and Lovibond & Lovibond’s depression, anxiety and stress scale (DASS-21. (sig. = 0.05 Finding: Total scores of Internet addiction and dependence on cell phone were 49.03±20 and 42.7±11.77 respectively. There was also a significant relationship between Internet addiction and the variables dependence on cell phone, depression, anxiety, and stress. (p<0.05 Conclusion: The results showed that increase in the time spent on the Internet led to increase in depression, anxiety, stress, and dependence on cell phone. Therefore, there is a need for more efficient educational, consultation, and behavioral planning to attenuate the psychological and social damages.

  12. Polirradiculoneurites de evolução prolongada: a propósito de dois casos corticóide-dependentes Chronic polyneuritis: report of two cases corticosteroid-dependents

    Directory of Open Access Journals (Sweden)

    Antonio Rodrigues de Mello

    1972-12-01

    Full Text Available São relatados dois casos de polirradiculoneurite de evolução prolongada. O primeiro caracterizou-se por ser recidivante em dois episódios e, o segundo, crônico, marcado por exacerbações sucessivas. Nos dois casos estabeleceu-se córtico-dependência, sendo ambos considerados como variantes evolutivas da síndrome de Guillain-Barré-Strohl.Two cases of chronic polyneuritis are reported. The first one was characterized by two recurrences and the second by chronic evolution with frequents exacerbations. In both there was corticosteroid-dependence. The authors concluded linking the cases to the Guillain-Barré-Strohl syndrome.

  13. No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case-control sample.

    Science.gov (United States)

    Nikolov, Momchil A; Beltcheva, Olga; Galabova, Antoaneta; Ljubenova, Anna; Jankova, Elena; Gergov, Galin; Russev, Atanas A; Lynskey, Michael T; Nelson, Elliot C; Nesheva, Eleonora; Krasteva, Dorita; Lazarov, Philip; Mitev, Vanio I; Kremensky, Ivo M; Kaneva, Radka P; Todorov, Alexandre A

    2011-08-01

    The μ-opioid receptor is the primary site of action of most opioids. The 118A>G (rs1799971) polymorphism in exon 1 of the μ-opioid receptor gene (OPRM1) leads to an Asn40Asp amino acid change that affects a putative N-glycosylation site. It has been widely investigated for association with alcohol and drug dependence and pain sensitivity, with mixed results. The aim of the current study was to examine whether this polymorphism was associated with heroin dependence in a large Bulgarian cohort of 1842 active users and 1451 population controls. SNP genotyping was done using Real-Time PCR TaqMan technology. Association analyses were conducted, separately for Roma and non-Roma participants. Our results suggest that there is no direct effect of 118A>G genotype on the risk for heroin dependence among active heroin users.

  14. Dramatic response in the dependency to transfusion after low doses of lenalidomide treatment in a 5q-syndrome patient: a case report.

    Science.gov (United States)

    Dogu, Mehmet Hilmi; Sari, Ismail; Hacioglu, Sibel; Keskin, Ali

    2014-01-01

    5q-syndrome is a special subgroup of myelodysplastic syndrome in terms of follow-up and treatment. Lenalidomide is an immunomodulatory drug that is frequently used in the treatment of multiple myeloma. Some clinical studies have shown that lenalidomide treatment is effective in 5q syndrome and significantly decreases the transfusion dependency in these patients. In this paper, we would like to share a dramatic response of lowered transfusion dependency after treatment with low-dose lenalidomide in a patient who received myelodysplastic syndrome diagnosis and isolated 5q anomaly in our clinic.

  15. Dependent Classes

    DEFF Research Database (Denmark)

    Gasiunas, Vaidas; Mezini, Mira; Ostermann, Klaus

    2007-01-01

    Virtual classes allow nested classes to be refined in subclasses. In this way nested classes can be seen as dependent abstractions of the objects of the enclosing classes. Expressing dependency via nesting, however, has two limitations: Abstractions that depend on more than one object cannot...... be modeled and a class must know all classes that depend on its objects. This paper presents dependent classes, a generalization of virtual classes that expresses similar semantics by parameterization rather than by nesting. This increases expressivity of class variations as well as the flexibility...... of their modularization. Besides, dependent classes complement multi-methods in scenarios where multi-dispatched abstractions rather than multi-dispatched method are needed. They can also be used to express more precise signatures of multi-methods and even extend their dispatch semantics. We present a formal semantics...

  16. The Investigation of Tramadol Dependence with No History of Substance Abuse: A Cross-Sectional Survey of Spontaneously Reported Cases in Guangzhou City, China

    Science.gov (United States)

    Zhang, Haoran; Liu, Zhimin

    2013-01-01

    The study was to survey and assess the drug dependence and abuse potential of tramadol with no history of substance abuse. Subjects of tramadol dependence with no prior history of substance abuse were surveyed by interview. Physical dependence of tramadol was assessed using 10 items opiate withdrawal scale (OWS), and psychological dependence was assessed by Addiction Research Center Inventory—Chinese Version (ARCI-CV). Twenty-three male subjects (the median age was 23.4 ± 4.1 years) referred to the addiction unit in Medical Hospital of Guangzhou with tramadol abuse problems were included in this cross-sectional study. The control group included 87 heroin addicts, 60 methamphetamine (MA) abusers, and 50 healthy men. The scores of OWS of tramadol were 0.83–2.30; the mean scores of identifying euphoric effects–MBG, sedative effects–PCAG, and psychotomimetic effects–LSD of ARCI were 8.96 ± 3.08, 6.52 ± 3.25, and 6.65 ± 2.50, respectively, F = 4.927, P tramadol did not differ from those in heroin and MA groups (P > 0.05) but were higher than those in healthy men (P Tramadol with no history of substance abuse has a clear risk of producing high abuse potential under the long-term infrequent abuse and the high doses. PMID:24151592

  17. The spectrum of non-classical Diamond-Blackfan anemia: a case of late beginning transfusion dependency associated to a new RPL5 mutation

    Directory of Open Access Journals (Sweden)

    Piero Farruggia

    2012-04-01

    Full Text Available Diamond Blackfan anemia typically presents in infants and is often associated with many kinds of malformations. Severity of anemia often needs transfusional support in the first months of life. We describe here a patient with Diamond Blackfan anemia related to a RPL5 mutation. The patient had no physical abnormalities and experienced a very late onset of transfusion dependency.

  18. The Investigation of Tramadol Dependence with No History of Substance Abuse: A Cross-Sectional Survey of Spontaneously Reported Cases in Guangzhou City, China

    Directory of Open Access Journals (Sweden)

    Haoran Zhang

    2013-01-01

    Full Text Available The study was to survey and assess the drug dependence and abuse potential of tramadol with no history of substance abuse. Subjects of tramadol dependence with no prior history of substance abuse were surveyed by interview. Physical dependence of tramadol was assessed using 10 items opiate withdrawal scale (OWS, and psychological dependence was assessed by Addiction Research Center Inventory—Chinese Version (ARCI-CV. Twenty-three male subjects (the median age was 23.4±4.1 years referred to the addiction unit in Medical Hospital of Guangzhou with tramadol abuse problems were included in this cross-sectional study. The control group included 87 heroin addicts, 60 methamphetamine (MA abusers, and 50 healthy men. The scores of OWS of tramadol were 0.83–2.30; the mean scores of identifying euphoric effects–MBG, sedative effects–PCAG, and psychotomimetic effects–LSD of ARCI were 8.96±3.08, 6.52±3.25, and 6.65±2.50, respectively, F = 4.927, P0.05 but were higher than those in healthy men (P<0.05. Tramadol with no history of substance abuse has a clear risk of producing high abuse potential under the long-term infrequent abuse and the high doses.

  19. 普瑞巴林治疗咖啡因依赖1例%A case of pregabalin for the treatment of caffeine dependence

    Institute of Scientific and Technical Information of China (English)

    温金峰; 张延赤; 宁连才

    2012-01-01

    目的:报道普瑞巴林治疗咖啡因急性戒断的疗效.方法:在咖啡因依赖患者的急性戒断期服用普瑞巴林.结果:服用普瑞巴林225 mg·d-1能够改善咖啡因依赖的急性戒断症状.结论:普瑞巴林可能通过抑制N-甲基-D-天门冬氨酸(NMDA)受体作用改善咖啡因依赖的急性戒断症状,具体作用机制有待进一步研究.%Objective:To report the efficacy of pregabalin for the treatment of acute withdrawal caffeine dependence. Methods: One patient with acute withdrawal symptoms of caffeine dependence was given pregabalin. Results; Taking pregabalin 225 mg·d -1 can improve the acute withdrawal symptoms of caffeine dependence. Conclusion ; Pregabalin may inhibit 7V-methyl-D-aspartic acid ( NMDA) receptor thus improve the acute withdrawal symptoms of caffeine dependence, and the specific mechanism needs further research.

  20. Dependency Parsing

    CERN Document Server

    Kubler, Sandra; Nivre, Joakim

    2009-01-01

    Dependency-based methods for syntactic parsing have become increasingly popular in natural language processing in recent years. This book gives a thorough introduction to the methods that are most widely used today. After an introduction to dependency grammar and dependency parsing, followed by a formal characterization of the dependency parsing problem, the book surveys the three major classes of parsing models that are in current use: transition-based, graph-based, and grammar-based models. It continues with a chapter on evaluation and one on the comparison of different methods, and it close

  1. How relevant is the predictive power of the h-index? A case study of the time-dependent Hirsch index

    CERN Document Server

    Schreiber, Michael

    2013-01-01

    The h-index has been shown to have predictive power. Here I report results of an empirical study showing that the increase of the h-index with time often depends for a long time on citations to rather old publications. This inert behavior of the h-index means that it is difficult to use it as a measure for predicting future scientific output.

  2. Stationary Light Waves in Anizotropy and Nonolinear Plane Media, whose Dielectric Tensor's Principal Values Arbitrarily Depend upon Intensity Case of Scattering

    CERN Document Server

    Ochirbat, G

    2000-01-01

    A plane medium, whose dielectric tensor's principal values arbitrarily depend upon intensity, is considered. The problems of the TM and TE waves, within the problem of light scattering, are reduced to quadrature. A question of integrability of the full system of Maxwell equations is discussed. A closed equation has been obtained for an auxiliary variable for a nonlinearity of Kerr type. A scheme for integrating the full system of Maxwell equations by solving the equation over the auxiliary variable is suggested.

  3. [Affective dependency].

    Science.gov (United States)

    Scantamburlo, G; Pitchot, W; Ansseau, M

    2013-01-01

    Affective dependency is characterized by emotional distress (insecure attachment) and dependency to another person with a low self-esteem and reassurance need. The paper proposes a reflection on the definition of emotional dependency and the confusion caused by various denominations. Overprotective and authoritarian parenting, cultural and socio-environmental factors may contribute to the development of dependent personality. Psychological epigenetic factors, such as early socio-emotional trauma could on neuronal circuits in prefronto-limbic regions that are essential for emotional behaviour.We also focus on the interrelations between dependent personality, domestic violence and addictions. The objective for the clinician is to propose a restoration of self-esteem and therapeutic strategies focused on autonomy.

  4. Mechanism Underlying Time-dependent Cross-phenomenon between Concentration-response Curves and Concentration Addition Curves: A Case Study of Sulfonamides-Erythromycin mixtures on Escherichia coli

    Science.gov (United States)

    Sun, Haoyu; Ge, Hongming; Zheng, Min; Lin, Zhifen; Liu, Ying

    2016-09-01

    Previous studies have identified a phenomenon in which the concentration-response curves (CRCs) for mixtures cross the curves for concentration addition model when predicting or judging joint toxic actions. However, mechanistic investigations of this phenomenon are extremely limited. In this study, a similar phenomenon was observed when we determined the joint toxic actions of sulfonamides (SAs) and erythromycin (ERY) on Escherichia coli (E. coli), which we named the “cross-phenomenon”, and it was characterized by antagonism in the low-concentration range, addition in the medium-concentration range, and synergism in the high-concentration range. The mechanistic investigation of the cross-phenomenon was as follows: SAs and ERY could form a double block to inhibit the bacterial growth by exhibiting a synergistic effect; however, the hormetic effect of SAs on E. coli led to antagonism in the low-concentration range, resulting from the stimulation of sdiA mRNA expression by SAs, which increased the expression of the efflux pump (AcrAB-TolC) to discharge ERY. Furthermore, this cross-phenomenon was observed to be a time-dependent process induced by the increase of both the concentration and extent of stimulation of sdiA mRNA with exposure time. This work explains the dose-dependent and time-dependent cross-phenomenon and provides evidence regarding the interaction between hormesis and cross-phenomenon.

  5. Micro and small business, liquidity, profitability and the postulate of the entity: the restaurants' case, in which continuity depends on owners financial reeducation

    Directory of Open Access Journals (Sweden)

    Luiz Fernando de Barros Scholz

    2015-12-01

    Full Text Available This work based on action research method is a case study in a small restaurant, with profitability and liquidity problems; in which one of the researchers was involved and sought to answer the questions of: How to measure the value creation of small and micro enterprises; and also on the impacts of no separation between accounting of the asset (small business and owner's accounting,  on business continuity. This paper has the goal to present in a more systematic methodological approach, the processes used in the technical solution of the case, as well as the solutions adopted and referrals. The technical solution forwarded made use of accounting information to diagnose and generate alternative solutions. These involved technical and behavioral aspects and were not adopted in its entirety by the company's shareholders during the period of performance of one of the researchers in the entity.

  6. Curvature dependence of semiclassical corrections to ray optics: How Goos-Hänchen shift and Fresnel filtering deviate from the planar case result

    Science.gov (United States)

    Stockschläder, P.; Kreismann, J.; Hentschel, M.

    2014-09-01

    Ray optics is a useful tool even in the regime where, actually, full wave calculations would be appropriate. However, wave-inspired adjustments are needed to ensure the accuracy of ray-based predictions. Here, we investigate these semiclassical corrections to the ray picture —the Goos-Hänchen shift and the Fresnel filtering effect— for the reflection of light beams at curved, rather than planar, interfaces. We present analytical and numerical results that highlight the role of boundary curvature and show clear deviations from the planar case. The Goos-Hänchen shift is decreased at convexely curved interfaces present in optical microcavities and microlasers compared to the planar case, and increased for concave curvature. In contrast, the Fresnel filtering effect is increased by both kinds of curvature. For a straightforward explanation of these findings we introduce an intuitive picture that explicitly takes curvature into account and that allows for a qualitative understanding of the beam shift behaviour.

  7. The effect of leisure-time physical activity on the risk of acute myocardial infarction depending on Body Mass Index: a population-based case-control study

    Directory of Open Access Journals (Sweden)

    Reuterwall Christina

    2006-12-01

    Full Text Available Abstract Background High body mass index (BMI and lack of physical activity have been recognized as important risk factors for coronary heart disease. The aim of the present study was to evaluate whether leisure-time physical activity compensates for the increased risk of acute myocardial infarction associated with overweight and obesity. Methods Data from the SHEEP (Stockholm Heart Epidemiology Program study were used. The SHEEP study is a large Swedish population-based case-control study, comprising 1204 male and 550 female cases, and 1538 male and 777 female controls, conducted in Stockholm County, Sweden, during the period 1992–1994. Odds ratios (OR, together with 95 % confidence intervals (95% CI, were calculated using unconditional logistic regression, as estimates of the relative risks. Results Regular leisure-time physical activity was associated with a decreased risk of myocardial infarction among lean, normal-weight and overweight subjects, but not among obese subjects. Obese (BMI ≥ 30 and physically active persons had an almost twofold risk of myocardial infarction, compared with normal-weight and sedentary persons (OR 1.85, 95% CI 1.07–3.18. The results were similar for men and women. Conclusion While regular leisure-time physical activity seems to provide protection against myocardial infarction among lean, normal-weight and overweight subjects, this does not appear to be the case in obese subjects.

  8. COMPRESSIBLE NAVIER-STOKES EQUATIONS WITH DENSITY-DEPENDENT VISCOSITY,VACUUM AND GRAVITATIONAL FORCE IN THE CASE OF GENERAL PRESSURE

    Institute of Scientific and Technical Information of China (English)

    Yao Lei; Wang Wenjun

    2008-01-01

    This is a continuation of the article (Comm. Partial Differential Equations 26 (2001) 965). In this article, the authors consider the one-dimensional compressible isentropic Navier-Stokes equations with gravitational force, fixed boundary condition, a general pressure and the density-dependent viscosity coefficient when the viscous gas con-nects to vacuum state with a jump in density. Precisely, the viscosity coefficient u is proportional to pθ and 0 < θ < 1/2, where p is the density, and the pressure P =P(p) is a general pressure. The global existence and the uniqueness of weak solution are proved.

  9. Hermite-distributed approximating functional-based formulation of multiconfiguration time-dependent Hartree method: A case study of quantum tunnelling in a coupled double-well system

    Indian Academy of Sciences (India)

    KAUSHIK MAJI

    2016-08-01

    We propose a variant of the multiconfiguration time-dependent Hartree (MCTDH) method within the framework of Hermite-distributed approximating functional (HDAF) method. The discretized Hamiltonian is a highly banded Toeplitz matrix which significantly reduces computational cost in terms of both storage and number of operations. The method proposed is employed to carry out the study of tunnelling dynamics of two coupled double well oscillators. We have calculated the orthogonality time \\tau , which is a measure of the time interval for an initial state to evolve into its orthogonal state. It is observed that the coupling has a significant effect on \\tau .

  10. Challenging Adiabatic Time-dependent Density Functional Theory with a Hubbard Dimer: The Case of Time-Resolved Long-Range Charge Transfer

    CERN Document Server

    Fuks, Johanna I

    2014-01-01

    We explore an asymmetric two-fermion Hubbard dimer to test the accuracy of the adiabatic approximation of time-dependent density functional theory in modelling time-resolved charge transfer. We show that the model shares essential features of a ground state long-range molecule in real-space, and by applying a resonant field we show that the model also reproduces essential traits of the CT dynamics. The simplicity of the model allows us to propagate with an "adiabatically-exact" approximation, i.e. one that uses the exact ground-state exchange-correlation functional, and compare with the exact propagation. This allows us to study the impact of the time-dependent charge-transfer step feature in the exact correlation potential of real molecules on the resulting dynamics. Tuning the parameters of the dimer allows a study both of charge-transfer between open-shell fragments and between closed-shell fragments. We find that the adiabatically-exact functional is unable to properly transfer charge, even in situations ...

  11. Forest Dependent Indigenous Communities’ Perception and Adaptation to Climate Change through Local Knowledge in the Protected Area—A Bangladesh Case Study

    Directory of Open Access Journals (Sweden)

    Habibur Rahman

    2016-02-01

    Full Text Available Forest-dependent indigenous communities rely on natural resources for their livelihoods, but those are currently under threat due to many factors, including the adverse impact of climate change. The present study looks into climate change-related perception and adaptation strategies of three forest-dependent indigenous communities, namely, Khasia, Tripura and Garo in the Lawachara National Park of Northeastern Bangladesh. Household surveys, focus group discussions, key informant interviews, and observation methods were used to unveil the climatic events, impacts and related adaptations. The events include the change in temperature and rainfall patterns, landslide, soil erosion and flash flood, heavy cold and fog, and natural calamities. Moreover, livelihood problems emanating from these events are the drying up of streams and wells, irregular rainfall, increased dieback and mortality of seedlings, pests, diseases, and the attack of crops by wild animals. Likewise, the reduction of soil moisture content, growing season and crop productivity, landslides, damage of roads and culverts, and increased human diseases are common. This study recognized 29 adaptation strategies and divided them into six management categories, drawing on their local knowledge of the natural resources and other technologies. The study reveals that, although adaptation strategies through land use and land cover changes are not enough to sustain their livelihoods, the tactics help them to reduce the risk of, and increase food security and community resilience against, climate change.

  12. Native Valve Streptococcus bovis Endocarditis and Refractory Transfusion Dependent Iron Deficiency Anaemia Associated with Concomitant Carcinoma of the Colon: A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Abdul Azeez Ahamed Riyaaz

    2016-01-01

    Full Text Available Streptococcus bovis is found as a commensal organism in human gut and may become opportunistically pathogenic. Infective endocarditis is one of the commonest modes of presentation of this infection. The association between Streptococcus bovis endocarditis and colorectal cancer is well recognized. We report a case of Streptococcus bovis endocarditis along with a refractory iron deficiency anaemia associated with concomitant carcinoma of ascending colon in a 63-year-old male. Cooccurrence of these two conditions may cause a challenge in the management. Considering the strong association of colon cancer with Streptococcus bovis endocarditis, a detailed screening colonoscopy is mandatory following the diagnosis of the latter.

  13. Portfolio effect of wind power plants based on wind regime dependency. Portugal case-study. Estimating the uncertainty benefit of wind farm portfolios in Portuguese wind regimes

    Energy Technology Data Exchange (ETDEWEB)

    Jorge, N.F.; Trivino, C.; Marco, J.M. [GL Garrad Iberica, S.L.U., Lisbon (Portugal)

    2012-07-01

    The uncertainty associated with the wind variability on wind farm energy production estimate may be mitigated when considering several wind farms within a portfolio rather than isolated. If two wind farms are geographically disperse in such a way that the wind regime in which wind farm is immersed can be considered independent or at least partly independent, the deviations on the annual energy production from the average of each wind farm may compensate each other - the so called ''portfolio effect''. This is an important feature for investors and operators when quantifying the associated uncertainty of the predicted energy yield of the overall portfolio for future timescales such as 1- year or 10-years periods. The methodology to determine the degree of dependency between wind regimes have been applied in an hypothetical portfolio of seven wind farms dispersed from north to south in continental Portugal. (orig.)

  14. Density-dependent benefits in ant-hemipteran mutualism? The case of the ghost ant Tapinoma melanocephalum (Hymenoptera: Formicidae) and the invasive mealybug Phenacoccus solenopsis (Hemiptera: Pseudococcidae).

    Science.gov (United States)

    Zhou, Aiming; Kuang, Beiqing; Gao, Yingrui; Liang, Guangwen

    2015-01-01

    Although density-dependent benefits to hemipterans from ant tending have been measured many times, few studies have focused on integrated effects such as interactions between ant tending, natural enemy density, and hemipteran density. In this study, we tested whether the invasive mealybug Phenacoccus solenopsis is affected by tending by ghost ants (Tapinoma melanocephalum), the presence of parasitoids, mealybug density, parasitoid density and interactions among these factors. Our results showed that mealybug colony growth rate and percentage parasitism were significantly affected by ant tending, parasitoid presence, and initial mealybug density separately. However, there were no interactions among the independent factors. There were also no significant interactions between ant tending and parasitoid density on either mealybug colony growth rate or percentage parasitism. Mealybug colony growth rate showed a negative linear relationship with initial mealybug density but a positive linear relationship with the level of ant tending. These results suggest that benefits to mealybugs are density-independent and are affected by ant tending level.

  15. Origin of the size-dependence of the polarizability per atom in heterogeneous clusters: The case of AlP clusters.

    Science.gov (United States)

    Krishtal, Alisa; Senet, Patrick; Van Alsenoy, Christian

    2010-10-21

    An analysis of the atomic polarizabilities α in stoichiometric aluminum phosphide clusters, computed at the MP2 and density functional theory (DFT) levels, the latter using the B3LYP functional, and partitioned using the classic and iterative versions of the Hirshfeld method, is presented. Two sets of clusters are examined: the ground-state Al(n)P(n) clusters (n=2-9) and the prolate clusters (Al(2)P(2))(N) and (Al(3)P(3))(N) (N≤6). In the ground-state clusters, the mean polarizability per atom, i.e., α/2n, decreases with the cluster size but shows peaks at n=5 and at n=7. We demonstrate that these peaks can be explained by a large polarizability of the Al atoms and by a low polarizability of the P atoms in Al(5)P(5) and Al(7)P(7) due to the presence of homopolar bonds in these clusters. We show indeed that the polarizability of an atom within an Al(n)P(n) cluster depends on the cluster size and the heteropolarity of the bonds it forms within the cluster, i.e., on the charges of the atoms. The polarizabilities of the fragments Al(2)P(2) and Al(3)P(3) in the prolate clusters were found to depend mainly on their location within the cluster. Finally, we show that the iterative Hirshfeld method is more suitable than the classic Hirshfeld method for describing the atomic polarizabilities and the atomic charges in clusters with heteropolar bonds, although both versions of the Hirshfeld method lead to similar conclusions.

  16. Post-Newtonian factorized multipolar waveforms for spinning, non-precessing black-hole binaries

    CERN Document Server

    Pan, Yi; Fujita, Ryuichi; Racine, Etienne; Tagoshi, Hideyuki

    2010-01-01

    We generalize the factorized resummation of multipolar waveforms introduced by Damour, Iyer and Nagar to spinning black holes. For a nonspinning test-particle spiraling a Kerr black hole in the equatorial plane, we find that factorized multipolar amplitudes which replace the residual relativistic amplitude f_{l m} with its l-th root, \\rho_{l m} = f_{l m}^{1/l}, agree quite well with the numerical amplitudes up to the Kerr-spin value q \\leq 0.95 for orbital velocities v \\leq 0.4. The numerical amplitudes are computed solving the Teukolsky equation with a spectral code. The agreement for prograde orbits and large spin values of the Kerr black hole can be further improved at high velocities by properly factoring out the lower-order post-Newtonian contributions in \\rho_{l m}. The resummation procedure results in a better and systematic agreement between numerical and analytical amplitudes (and energy fluxes) than standard Taylor-expanded post-Newtonian approximants. This is particularly true for higher-order mode...

  17. Path Dependence

    DEFF Research Database (Denmark)

    Madsen, Mogens Ove

    Begrebet Path Dependence blev oprindelig udviklet inden for New Institutionel Economics af bl.a. David, Arthur og North. Begrebet har spredt sig vidt i samfundsvidenskaberne og undergået en udvikling. Dette paper propagerer for at der er sket så en så omfattende udvikling af begrebet, at man nu kan...... tale om 1. og 2. generation af Path Dependence begrebet. Den nyeste udvikling af begrebet har relevans for metodologi-diskusionerne i relation til Keynes...

  18. Density-Dependent Benefits in Ant-Hemipteran Mutualism? The Case of the Ghost Ant Tapinoma melanocephalum (Hymenoptera: Formicidae) and the Invasive Mealybug Phenacoccus solenopsis (Hemiptera: Pseudococcidae)

    Science.gov (United States)

    Zhou, Aiming; Kuang, Beiqing; Gao, Yingrui; Liang, Guangwen

    2015-01-01

    Although density-dependent benefits to hemipterans from ant tending have been measured many times, few studies have focused on integrated effects such as interactions between ant tending, natural enemy density, and hemipteran density. In this study, we tested whether the invasive mealybug Phenacoccus solenopsis is affected by tending by ghost ants (Tapinoma melanocephalum), the presence of parasitoids, mealybug density, parasitoid density and interactions among these factors. Our results showed that mealybug colony growth rate and percentage parasitism were significantly affected by ant tending, parasitoid presence, and initial mealybug density separately. However, there were no interactions among the independent factors. There were also no significant interactions between ant tending and parasitoid density on either mealybug colony growth rate or percentage parasitism. Mealybug colony growth rate showed a negative linear relationship with initial mealybug density but a positive linear relationship with the level of ant tending. These results suggest that benefits to mealybugs are density-independent and are affected by ant tending level. PMID:25886510

  19. Density-dependent benefits in ant-hemipteran mutualism? The case of the ghost ant Tapinoma melanocephalum (Hymenoptera: Formicidae and the invasive mealybug Phenacoccus solenopsis (Hemiptera: Pseudococcidae.

    Directory of Open Access Journals (Sweden)

    Aiming Zhou

    Full Text Available Although density-dependent benefits to hemipterans from ant tending have been measured many times, few studies have focused on integrated effects such as interactions between ant tending, natural enemy density, and hemipteran density. In this study, we tested whether the invasive mealybug Phenacoccus solenopsis is affected by tending by ghost ants (Tapinoma melanocephalum, the presence of parasitoids, mealybug density, parasitoid density and interactions among these factors. Our results showed that mealybug colony growth rate and percentage parasitism were significantly affected by ant tending, parasitoid presence, and initial mealybug density separately. However, there were no interactions among the independent factors. There were also no significant interactions between ant tending and parasitoid density on either mealybug colony growth rate or percentage parasitism. Mealybug colony growth rate showed a negative linear relationship with initial mealybug density but a positive linear relationship with the level of ant tending. These results suggest that benefits to mealybugs are density-independent and are affected by ant tending level.

  20. Down-regulation of outer membrane proteins by noncoding RNAs: unraveling the cAMP-CRP- and sigmaE-dependent CyaR-ompX regulatory case

    DEFF Research Database (Denmark)

    Johansen, Jesper; Eriksen, Maiken; Kallipolitis, Birgitte

    2008-01-01

    The sigma(E) (extracytoplasmic stress response sigma factor in Escherichia coli) signaling system of Gram-negative bacteria plays an essential role in the maintenance of the extracytoplasmic compartment. Upon induction of this system, approximately 100 genes are up-regulated. The majority...... is sufficient to trigger the envelope stress response. Recent work indicates that small Hfq-binding RNAs play a major role in maintaining envelope homeostasis and, so far, two sigma(E)-dependent small noncoding RNAs (sRNAs), MicA and RybB, have been shown to facilitate rapid removal of multiple omp transcripts...... is also up-regulated, directly or indirectly, by sigma(E). In addition, this work identified MicA as a factor that cooperates in the negative control of ompX expression. The conservation of CyaR, MicA, RybB, and their targets suggests that the omp mRNA-sRNA regulatory network is an integral part...

  1. Effects of temperature on the nitric oxide-dependent modulation of the Frank-Starling mechanism: the fish heart as a case study.

    Science.gov (United States)

    Amelio, D; Garofalo, F; Capria, C; Tota, B; Imbrogno, S

    2013-02-01

    The Frank-Starling law is a fundamental property of the vertebrate myocardium which allows, when the end-diastolic volume increases, that the consequent stretch of the myocardial fibers generates a more forceful contraction. It has been shown that in the eel (Anguilla anguilla) heart, nitric oxide (NO) exerts a direct myocardial relaxant effect, increasing the sensitivity of the Frank-Starling response (Garofalo et al., 2009). With the use of isolated working heart preparations, this study investigated the relationship between NO modulation of Frank-Starling response and temperature challenges in the eel. The results showed that while, in long-term acclimated fish (spring animals perfused at 20 °C and winter animals perfused at 10 °C) the inhibition of NO production by L-N5 (1-iminoethyl)ornithine (L-NIO) significantly reduced the Frank-Starling response, under thermal shock conditions (spring animals perfused at 10 or 15 °C and winter animals perfused at 15 or 20 °C) L-NIO treatment resulted without effect. Western blotting analysis revealed a decrease of peNOS and pAkt expressions in samples subjected to thermal shock. Moreover, an increase in Hsp90 protein levels was observed under heat thermal stress. Together, these data suggest that the NO synthase/NO-dependent modulation of the Frank-Starling mechanism in fish is sensitive to thermal stress.

  2. Facial hormone-dependent dermatitis: a clinical analysis of 68 cases%面部激素依赖性皮炎临床分析及其治疗效果

    Institute of Scientific and Technical Information of China (English)

    黄静

    2010-01-01

    Objective To explore the incidence of facial hormone-dependent dermatitis, and to raise the healing rate of it. Methods We applied non-steroid drug topically, cold compress combined with anti-histamine agents to treat facial hormone-dependent dermatitis in 68 cases. The results were compared before and after the treatment. Results There were significantly clinical effects of non-steroid drug topically, cold compress combined with antihistamine agents on facial hormone-dependent dermatitis, with healing rate of 82. 4 % , and effective rate of 100 %. Conclusions In order to reduce the incidence of facial hormone-dependent dermatitis, we should follow the principal of applying steroid agent strictly to treat facial dermatitis. Meanwhile, there is significantly clinical effects of non-steroid drug with topical use and cold compress combined with antihistamine agents on facial steroid-dependent dermatitis.%目的 探讨减少面部激素依赖性皮炎的发生率和提高治愈率.方法 对68例面部激素依赖性皮炎治疗采用外用冷敷收敛联合内服抗组胺药,并对治疗效果进行对比分析.结果 采用外用、冷敷收敛联合抗组胺药取得满意疗效,痊愈率82.4%,有效率100%.结论 在使用糖皮质激素时,应严格掌握外用药物使用原则,减少面部激素依赖性皮炎的发生.采取内服、外用药物的综合治疗方法 ,对面部激素依赖性皮炎可以取得较好的临床疗效.

  3. Tracing man's impact on groundwater dependent ecosystem using geochemical an isotope tools combined with 3D flow and transport modeling: case study from southern Poland

    Science.gov (United States)

    Zurek, Anna; Witczak, Stanislaw; Kania, Jaroslaw; Wachniew, Przemyslaw; Rozanski, Kazimierz; Dulinski, Marek; Jench, Olga

    2013-04-01

    Thorough understanding of the link between terrestrial ecosystems and underlying groundwater reservoirs is an important element of sustainable management of groundwater resources in the light of ever growing anthropogenic pressure on groundwater reserves, both with respect to quantity and quality of this vital resource. While association of terrestrial ecosystems with surface water (rivers, streams, lakes, etc.) is visible and recognized, their link to underground components of the hydrological cycle is often forgotten and not appreciated. The presented study was aimed at investigating possible adverse effects of intensive exploitation of porous sandy aquifer on groundwater dependent terrestrial ecosystem (GDTE) consisting of a valuable forest stand and associated wetlands. The Bogucice Sands aquifer and the associated GDTE (Niepolomice Forest) are located in the south of Poland. The principal economic role of the aquifer, consisting of two water-bearing strata is to provide potable water for public and private users. Eastern part of the shallow phreatic aquifer is occupied by Niepolomice Forest. The Niepolomice Forest is a lowland forest covering around 110 km2. It is protected as a Natura 2000 Special Protection Area "Puszcza Niepołomicka" (PLB120002) which supports bird populations of European importance. Additionally, a fen in the western part of the forest comprises a separate Natura 2000 area "Torfowisko Wielkie Bloto" (PLH120080), a significant habitat of endangered butterfly species associated with wet meadows. Dependence of the Niepolomice Forest stands on groundwater is enhanced by low available water capacity and low capillary rise of soils. Groundwater conditions in the Niepolomice Forest, including Wielkie Bloto fen have been affected by meliorations carried out mostly after the Second World War and by forest management. In September 2009 a cluster of new pumping wells (Wola Batorska well-field) has been set up close to the northern boundary of

  4. RELATION OF HYPERTENSION TO DIABETIC NEPHROPATHY IN PATIENTS WITH NON INSULIN DEPENDENT DIABETES MELLITUS-A PAIR MATCHED CASE CONTROL STUDY

    Institute of Scientific and Technical Information of China (English)

    侯旭宏; 王建华; 冯凭

    2002-01-01

    Objective.To assess the role of hypertension and family history of hypertension in the development of nephropathy in patients with non insulin dependent diabetes mellitus (NIDDM). Methods.A retrospective analysis was done on 2 groups of NIDDM patients,one group without proteinuria (urine protein< 300mg/24h,n=106) and the other group with proteinuria (urine protein≥ 500mg/24h,n=106).The 2 groups were matched by age(≤± 3yrs),sex,ethnic and resident place.Some information of these subjects including demographic;history of disease,family history of diseases,lifestyle and behavior style variables was obtained by questionnaire;some variables were measured,including systolic blood pressure (SBP),diastolic blood pressure (DBP),fasting blood glucose (FBG),quantity of protein in 24h urine.Then conditional logistic regression analysis was performed. Results.Some factors,including history of hypertension,longer duration of hypertension,higher levels of the past highest SBP and DBP,were independently associated with the occurrence risk of diabetic nephropathy (DN).Their corresponding odd ratios (OR) with 95% confidence intervals (CI) were 2.00(1.17~3.43),1.25(1.08~1.46),1.38(1.15~1.66),and 1.33(1.09~1.62) respectively,but family history of hypertension was not significantly associated with the development of DN.When the above mentioned relations were respectively adjusted by some possible confounding factors,they still existed. Conclusions.History of hypertension,longer duration of hypertension,higher levels of the past highest SBP and DBP are independent risk factors for DN in Chinese NIDDM patients.

  5. Identifying long-term variations in vegetation and climatic variables and their scale-dependent relationships: A case study in Southwest Germany

    Science.gov (United States)

    Liu, Zhiyong; Menzel, Lucas

    2016-12-01

    and precipitation regimes. For the scale-dependent relationships between NDVI and precipitation, the 2-month and 8-month scales generally present the strongest negative correlation. The most significant positive correlations between NDVI and temperature are obtained at the 8- to 16-month scales for most vegetation types. The results of the present study might be beneficial for water resources management as well as agricultural and ecological development planning in Rhineland-Palatinate, and also provide a helpful reference for other regions with similar climate condition.

  6. Loperamide dependence and abuse.

    Science.gov (United States)

    MacDonald, Ryan; Heiner, Jason; Villarreal, Joshua; Strote, Jared

    2015-05-02

    Loperamide is a common over-the-counter antidiarrheal considered safe in a broad range of dosages and thought devoid of abuse potential. We describe the first case of a patient with loperamide dependence due to misuse of its opiate-like effects achieved by chronic massive oral ingestions. A 26-year-old man who was taking 800 mg of loperamide per day presented requesting detoxification referral. Loperamide has potential for euphoric effects and information on how to facilitate such effects is easily available. It is important for physicians to be aware of the potential for misuse of and dependence on loperamide, with symptoms mimicking opiate use.

  7. [Pyridoxine dependent seizures].

    Science.gov (United States)

    Hansen, K N; Ostergaard, J R; Møller, S M

    1994-10-17

    Pyridoxine dependent seizures is a rare autosomal recessive disorder. Its manifestations are intractable epilepsy leading to death in status epilepticus. Treatment with pyridoxine prevents the seizures and normalizes the EEG. Early diagnosis is important for the intellectual outcome. In Denmark, the disease has occurred in a child of healthy Tamil immigrants, who are first cousins. The child's case story is described and points to awareness of increased occurrence of rare autosomal recessive disorders in immigrants from cultures with traditional consanguinity. We suggest giving a pyridoxine test dosis to all cases of severe epilepsy and status epilepticus in infants younger than 18 months.

  8. Measurement dependent locality

    Science.gov (United States)

    Pütz, Gilles; Gisin, Nicolas

    2016-05-01

    The demonstration and use of Bell-nonlocality, a concept that is fundamentally striking and is at the core of applications in device independent quantum information processing, relies heavily on the assumption of measurement independence, also called the assumption of free choice. The latter cannot be verified or guaranteed. In this paper, we consider a relaxation of the measurement independence assumption. We briefly review the results of Pütz et al (2014 Phys. Rev. Lett. 113 190402), which show that with our relaxation, the set of so-called measurement dependent local (MDL) correlations is a polytope, i.e. it can be fully described using a finite set of linear inequalities. Here we analyze this polytope, first in the simplest case of two parties with binary inputs and outputs, for which we give a full characterization. We show that partially entangled states are preferable to the maximally entangled state when dealing with measurement dependence in this scenario. We further present a method which transforms any Bell-inequality into an MDL inequality and give valid inequalities for the case of arbitrary number of parties as well as one for arbitrary number of inputs. We introduce the assumption of independent sources in the measurement dependence scenario and give a full analysis for the bipartite scenario with binary inputs and outputs. Finally, we establish a link between measurement dependence and another strong hindrance in certifying nonlocal correlations: nondetection events.

  9. Pyridoxine-dependent seizures and microcephaly.

    Science.gov (United States)

    Tan, Hüseyin; Kardaş, Fatih; Büyükavci, Mustafa; Karakelleoğlu, Cahit

    2004-09-01

    Pyridoxine dependency is a rare autosomal-recessive disorder causing intractable seizures in neonates and infants. This case report describes an infant with pyridoxine-dependent seizures with microcephaly and discusses a probable pathogenetic mechanism of microcephaly in this condition.

  10. Case report

    DEFF Research Database (Denmark)

    Füchtbauer, Laila; Brusgaard, Klaus; Ledaal, Pål;

    2015-01-01

    ey Clinical Message Vitamin D-dependent rickets type 1 VDDR-1 is a recessive inherited disorder with impaired activation of vitamin D, caused by mutations in CYP27B1. We present long-time follow-up of a case with a novel mutation including high-resolution peripheral quantitative computed tomography...

  11. Current status of cannabis treatment of multiple sclerosis with an illustrative case presentation of a patient with MS, complex vocal tics, paroxysmal dystonia, and marijuana dependence treated with dronabinol.

    Science.gov (United States)

    Deutsch, Stephen I; Rosse, Richard B; Connor, Julie M; Burket, Jessica A; Murphy, Mary E; Fox, Fiona J

    2008-05-01

    Pain, spasticity, tremor, spasms, poor sleep quality, and bladder and bowel dysfunction, among other symptoms, contribute significantly to the disability and impaired quality of life of many patients with multiple sclerosis (MS). Motor symptoms referable to the basal ganglia, especially paroxysmal dystonia, occur rarely and contribute to the experience of distress. A substantial percentage of patients with MS report subjective benefit from what is often illicit abuse of extracts of the Cannabis sativa plant; the main cannabinoids include delta-9-tetrahydrocannabinol (delta9-THC) and cannabidiol. Clinical trials of cannabis plant extracts and synthetic delta9-THC provide support for therapeutic benefit on at least some patient self-report measures. An illustrative case is presented of a 52-year-old woman with MS, paroxysmal dystonia, complex vocal tics, and marijuana dependence. The patient was started on an empirical trial of dronabinol, an encapsulated form of synthetic delta9-THC that is usually prescribed as an adjunctive medication for patients undergoing cancer chemotherapy. The patient reported a dramatic reduction of craving and illicit use; she did not experience the "high" on the prescribed medication. She also reported an improvement in the quality of her sleep with diminished awakenings during the night, decreased vocalizations, and the tension associated with their emission, decreased anxiety and a decreased frequency of paroxysmal dystonia.

  12. Food Dependent Exercise-induced Anaphylaxis: 3 Cases Report and Literature Review%食物依赖运动诱发严重过敏3例并文献复习

    Institute of Scientific and Technical Information of China (English)

    祝戎飞; 黄南; 刘惠龙; 刘光辉

    2011-01-01

    目的:提高对食物依赖运动诱发严重过敏(FDEIA)的诊疗水平.方法:回顾分析3例食物依赖运动诱发过敏反应患者的临床特征及诊疗情况,并复习相关文献.结果:2例患者在进食小麦面食后,1例患者在进食海虾后由运动诱发全身荨麻疹、呼吸困难及意识障碍,发病时间均在进食食物后30min~2h,经肾上腺素、糖皮质激素及抗组胺药物治疗后缓解.3例患者致敏食物皮肤点刺试验和血清特异性IgE均为阳性.2例患者在禁食致敏食物1年,随访期间未发生过敏反应.结论:FDEIA临床罕见,患者可反复发生过敏性休克而导致死亡,临床进食某些食物过敏原和进食后运动2个因素同时存在时才会诱发FDEIA,治疗方法以抗组胺药物、肾上腺素和糖皮质激素等对症治疗为主,禁食致敏食物及进食致敏食物后4h内避免剧烈运动有可能避免本病的发生.%Objective: To improve the diagnosis and treatment of food-dependent exercise-induced anaphylaxis (FDEIA). Methods: Clinical features, diagnosis and treatment of 3 patients with FDEIA were analyzed with literature review. Results: Three cases experienced exercise induced urticaria, breathing difficulties and impairment of consciousness in 30 minutes to 2 hours after taken allergic foods (2 cases for wheat and 1 case for shrimp). Patients symptoms were relieved after treated with anti-histamine, corticosteroids and adrenaline. The results of skin prick test and specific IgE to food were positive. Two cases had no anaphylaxis attack after avoiding causative food during 1 years follow-up. Conclusions: FDEIA are rare in clinic. Patients may die from repeated anaphylactic shock. Only simultaneous existence of taking allergenic food and subsequent exercise can induce FDEIA. Avoidance of exercise for 4 hours after eating causative food might be helpful to prevent the occurrence of symptoms in many FDEIA cases. Dietary avoidance of causative food ingredients

  13. The level of nicotine dependence is an independent risk factor for cancer: a case control study O nível de dependência da nicotina é um fator de risco independente para o câncer: um estudo caso-controle

    Directory of Open Access Journals (Sweden)

    Daniel Deheinzelin

    2005-06-01

    Full Text Available BACKGROUND: Less than 20% of lifetime smokers will ever develop cancer. Smoking habits characteristics, particularly the level of nicotine dependence level, were not fully evaluated as a marker of risk. METHODS: Case-control study of voluntary patients prospectively enrolled in a smoking cessation program in a cancer hospital. For each cancer case, patients of the same age and sex were selected. The Beck Depression Inventory, an instrument for the diagnosis of depressive mood and clinical depression, and the Fagerström Test Questionnaire, a questionnaire that has a good correlation with nicotine levels, used to determine the degree of dependence on nicotine, were applied. Age on admission to the study, sex, and number of pack-years were also evaluated. RESULTS: From May 1999 to May 2002, 56 cancer patients (case and 85 matching controls (control were identified in the population studied. There was no difference regarding pack-years. Fagerström Test Questionnaire was significantly higher in patients with cancer (7.5 ± 1.9 compared to controls (6.3 ± 2.0. We found a Fagerström Test Questionnaire > 7 in 73.2% of the cancer cases versus 43.5% of the controls (p=0.001. The proportion of depressed patients was higher in the cancer group (37.5% x 17.6%. Logistic regression adjusted for age and tobacco consumption disclosed that Fagerström Test Questionnaire score > 7 has an odds ratio for cancer of 3.45 (95% CI 1.52 - 7.83, p = 0.003. CONCLUSION: Fagerström Test Questionnaire higher than 7 was identified as a risk factor for cancer in smokers with similar tobacco consumption.OBJETIVO: Menos de 20% dos fumantes crônicos desenvolverá cancer. As características do hábito de fumar, particularmente o nível de dependência à nicotina, não foram avaliadas inteiramente como um marcador do risco. MÉTODOS: Estudo caso-controle de pacientes voluntários, registrados prospectivamente em um programa de cessação de tabagismo em um hospital de cancer

  14. MEASURING PATH DEPENDENCY

    Directory of Open Access Journals (Sweden)

    Peter Juhasz

    2017-03-01

    Full Text Available While risk management gained popularity during the last decades even some of the basic risk types are still far out of focus. One of these is path dependency that refers to the uncertainty of how we reach a certain level of total performance over time. While decision makers are careful in accessing how their position will look like the end of certain periods, little attention is given how they will get there through the period. The uncertainty of how a process will develop across a shorter period of time is often “eliminated” by simply choosing a longer planning time interval, what makes path dependency is one of the most often overlooked business risk types. After reviewing the origin of the problem we propose and compare seven risk measures to access path. Traditional risk measures like standard deviation of sub period cash flows fail to capture this risk type. We conclude that in most cases considering the distribution of the expected cash flow effect caused by the path dependency may offer the best method, but we may need to use several measures at the same time to include all the optimisation limits of the given firm

  15. A clinical observation of 107 cases of collagen dressing in treatment of facial hormone dependent dermatitis%107例胶原帖敷料治疗面部激素依赖性皮炎的疗效观察

    Institute of Scientific and Technical Information of China (English)

    何小亮; 王晓霞

    2015-01-01

    Objective To investigate clinical effect of collagen dressing in treatment of facial hormone dependent dermatitis.Methods 107 patients were divided randomly into treatment group and control group.53 cases of control group were given citrate desloratadine,ompound glycyrrhizin tablets, 0.3% tacrolimus ointment, cod liver oil ointment for 4 weeks.54 cases of treatment group were given collagen dressing 25 minutesper night, based on control group.After 4 weeks of drug treatment,treatment group continued to be given collagen dressing once every other night, control group were given cod liver oil ointment twice a day, morning and night.Both groups continued to observe for 12 weeks, at the same time, 0.3% tacrolimus ointment was given once every other day.Compared effect of two groups in the short-term and long-term.Results There were no significant differences in symptom scores between the two groups pre-treatment; compared with pre-treatment,the symptom scores were decreased(P<0.05).Compared with control group, the symptoms of treatment group were lower than that of treatment group(P<0.05).Compared with control group, the clinical total effective rate was higher than treatment group ( P<0.05 ) .Conclusion The collagen dressing can improve the facial treatment of hormone-dependent dermatitis.%目的:观察胶原帖敷料治疗面部激素依赖性皮炎的临床疗效。方法将107例患者随机分为2组。53例对照组予枸地氯雷他定、复方甘草酸苷片、0.3%他克莫司软膏、鱼肝油软膏外用治疗4周。54例治疗组在对照组基础上每晚使用胶原帖敷料25 min。4周药物治疗后治疗组每2晚继续使用1次胶原帖敷料,对照组早晚使用鱼肝油软膏,继续观察12周,2组均继续隔天使用0.3%他克莫司软膏1次。对比2组患者短期和长期疗效。结果2组患者治疗前症状评分比较,差异无统计学意义;与治疗前比较,2组治疗后2周、4周与3月症

  16. 地西泮合并心理干预治疗酒依赖伴抑郁35例疗效评价%Diazepam Combined with Psychological Intervention for Treating Alcohol Dependence Complicating Depression in 35 Cases

    Institute of Scientific and Technical Information of China (English)

    程宇; 余成民; 李宁佳; 冯婧; 李薇

    2015-01-01

    目的:观察地西泮合并心理干预治疗酒依赖伴抑郁的疗效。方法随机将70例患者分成地西泮合并心理干预治疗组(干预组)和单用地西泮治疗组(对照组),各35例,均治疗8周。于治疗前及治疗后采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、临床总体印象量表(CGI)评定临床疗效及不良反应。结果治疗后第1,2,4,8周末的HAMD,HAMA及CGI评分,干预组和对照组均显著低于治疗前( P﹤0.05),且干预组各时间点的评分均显著低于对照组( P﹤0.05);干预组总有效率为94.29%,显著高于对照组的74.29%( P﹤0.05);干预组不良反应发生率为25.71%,显著低于对照组的60.00%( P﹤0.05)。结论地西泮合并心理干预治疗酒依赖伴抑郁的疗效优于单用地西泮,且起效更快,不良反应少。%Objective To observe the clinical efficacy of diazepam combined with psychological intervention in the treatment of alcohol dependence complicating depression. Methods 70 patients with alcohol dependence complicating depression were randomly assigned to the intervention group treated by diazepam combined with the psychological intervention ( intervention group ) and single diazepam treat-ment group ( control group ) , 35 cases in each group. The treatment lasted for 8 weeks. The curative effects and adverse reactions were assessed before treatment and at the end of 1, 2, 4, 8 weeks by adopting the Hamilton depression scale ( HAMD ) , Hamilton anxiety scale ( HAMA ) , clinical general impression ( CGI ) and treatment emergent symptom scale ( TESS ) . Results The scores of HAMD, HAMA and CGI after 1, 2, 4, 8 weeks of treatment in both groups were significantly lower than before treatment ( P ﹤ 0. 05 ) , moreover which at var-ious time points in the intervention group were significantly lower than those in the control group ( P ﹤ 0. 05 ) The effective rate in the intervention group was 94

  17. Maintainence treatment of opioid dependence with tramadol

    OpenAIRE

    Siddharth Sarkar; Mohit Varshney; Vaibhav Patil; Rakesh Lal

    2017-01-01

    Background: Although tramadol has been used in the management of acute withdrawal in patients with opioid dependence, its use for maintenance treatment as a harm reduction approach has not been assessed systematically. This case series describes patients with opioid dependence who were treated with tramadol for long-term maintenance. Methods: Patients with opioid dependence who received treatment at the National Drug Dependence Treatment Centre of All India Institute of Medical Sciences, New ...

  18. On the impedance of galvanic cells XIX. The potential dependence of the faradaic impedance in the case of an irreversible electrode reaction; experimental verification for the redox couple Eu3+/Eu2+ In 1 M NaClO4 and The mechanism of the Zn2+/Zn(Hg) reaction in KCl

    NARCIS (Netherlands)

    Timmer, B.; Sluyters-Rehbach, M.; Sluyters, J.H.

    1967-01-01

    An experimental verification of the theory for the potential dependence of the faradaic impedance in the case of irreversible electrode reactions, described in part XVIII, is presented for the Eu3+/Eu2+ couple in 1 M NaClO4 at a D.M.E. It is shown that two peaks occur in an a.c. polarogram, if both

  19. Megadose bromazepam dependence.

    Science.gov (United States)

    Bastide, Anaïs; de Codt, Aloïse; Monhonval, Pauline; Bongaerts, Xavier; Tecco, Juan Martin

    2016-09-01

    Benzodiazepines (BZDs) are among the most widely prescribed drugs in developed countries. Since BZDs can produce tolerance and dependence even in a short time, their use is recommended for a very limited time. However, these recommendations have been largely disregarded. The chronic use of BZDs causes a number of serious side effects, i.e. cognitive impairment, falls, traffic accidents, dependence and tolerance. We present the case of a 37 years old woman taking daily doses of 220 mg of bromazepam. The patient's anxiety, depression and cognitive status were evaluated with a battery of questionnaires. A sleep laboratory test was performed in search of sleep apneas and sleepiness during the day. A Cerebral PET SCAN was executed in search of altered cerebral metabolism. Blood concentrations of bromazepam reached 7800 μg/L. Questionnaire evaluations showed significant depression and anxiety but only moderate cognitive impairment. Oxygen saturation was normal throughout the Sleep lab test, respiratory events were very few and sleepiness was moderate with an average latency of 9 minutes. Brain cortical glucose consumption was homogeneously slightly reduced. With doses of bromazepan reaching 15 times the toxic dose, anxiety remained high. Cognition, sleepiness, respiratory sleep events and brain metabolism remained remarkably close to normal.

  20. 135例苯二氮类药物依赖5年后的随访%Five-year follow-up of 135 cases with Benzodiazepine dependence

    Institute of Scientific and Technical Information of China (English)

    许宝贵; 冯丽娜; 刘姜慧

    2014-01-01

    目的::了解苯二氮类药物依赖后患者用药情况及对药物的态度。方法:对5年前进行调查的,符合 CCMD-Ⅲ精神活性物质所致精神障碍中镇静催眠药或抗焦虑药依赖综合征的诊断标准患者进行5年后的随访,采用自制的调查表进行调查评估。结果:①5年后随访时已有4例患者死亡,死亡原因全部为躯体疾病。②在这 5年中发生宿醉摔伤者6例,其中5例有不同程度的骨折,1例无骨折。③与 5年前相比单一用药从37.78%下降到21.37%。而2种以上药物合并使用从62.22%上升到78.63%。④5年后用药量增加者88例,占67.18%,而用药量减少者21例,占16.03%。⑤5年后用药频次增加者55例,占41.98%。而频次减少者11例,占8.40%。⑥5年后就诊2家以上医院者120例,占91.60%。其中就诊于3家以上医院者92例,占70.23%。⑦有意愿减少用药量者84例,占64.12%;但真正实施减少用药量行为者只有21例,占有意愿者中的25.00%;减量后100.00%出现躯体不舒适;担忧减量后存在隐患92例,占70.23%;担忧用药对健康不利者86例,占65.65% 。结论:随着时间的延长,患者对该类药物的用药量、用药频次、同类药物的合并应用等情况都在增加;患者就诊于多家医院可能与药物的不易得性及患者有躯体不适有关;有意愿减少用药量与真正实施行动者之间差距较大,可能与该类药物治疗效果相对比较满意致使患者长期用药、药物对患者的躯体及心理都产生了依赖、少有的药物替代等因素有关。%Objective: To understand the conditions of patients' medications after Benzodiazepine (BDZ) dependence and atti-tudes to the drugs. Methods: The cases diagnosed as the dependence syndrome of sedative-hypnotic or antianxiety drug in which men-tal disorders being due to use of psychoactive substances according to the CCMD-Ⅲ five years before were researched, and investigated and estimated

  1. Sparsity considerations for dependent observations

    CERN Document Server

    Alquier, Pierre

    2011-01-01

    The aim of this paper is to provide a comprehensive introduction for the study of L1-penalized estimators in the context of dependent observations. We define a general $\\ell_{1}$-penalized estimator for solving problems of stochastic optimization. This estimator turns out to be the LASSO in the regression estimation setting. Powerful theoretical guarantees on the statistical performances of the LASSO were provided in recent papers, however, they usually only deal with the iid case. Here, we study our estimator under various dependence assumptions.

  2. RELATIONAL ASPECTS OF RELATIONAL DATABASE DEPENDENCIES

    OpenAIRE

    Okuma, Hitomi; Kawahara, Yasuo

    2000-01-01

    This paper presents a relational treatment of inference rules for functional and multivalued dependencies in relational databases, to show the soundness and the completeness of the inference rules in Dedekind categories, which also cover the fuzzy case.

  3. 27例乙二胺四乙酸依赖性假性血小板减少特点及临床分析%Analysis of characters and biochemical profiles of 27 cases with EDTA-Dependent Pseudothrombocytopenia

    Institute of Scientific and Technical Information of China (English)

    于明; 靳海龙; 张宝秋

    2016-01-01

    Objective To analyze the characters about anticoagulation EDTA on the platelet aggregation ,and discuss the risk factors about EDTA‐PTCP by analyzing the biochemical parameters .Methods 30 700 EDTA‐K3 blood samples were collected from January 2014 to August 2015 .WBC was performed using Sysmex XN‐3000 and 27cases were identified of EDTA‐PTCP .The blood samples of 27 subjects were recollected and WBC was repeated using EDTA‐K3 and sodium citrate blood ,respectively .Manual platelet counting and smear microscope examination on periphery blood were also performed .Biochemical parameters of 27 subjects with EDTA‐PTCP were compared with 50 randomly selected non EDTA‐PTCP controls .Results Platelet counts in citrated blood were significantly higher than EDTA blood ,the difference was statistically significant(P0 .05) .ALT ,Glu and TG in patients with EDTA‐PTCP were significantly higher than normal people ,but HDL was significantly lower than control group ,the difference was statistically significant(P<0 .05) .Conclusion EDTA‐dependent pseudo‐thrombocytopenia varies from people with different disease or using different medicine .It may be relative to hyperglycemia and hy‐perlipidemia .Another approach for rectifying ,changing anticoagulant or manual platelet counting is a better way lead to correctly di‐agnose when EDTA‐PTCP occurred .%目的:分析乙二胺四乙酸(EDTA)导致血小板聚集的特点,探讨与此现象有关的危险因素。方法用Sysmex XN‐3000对2014年1月至2015年8月间的30700例EDTA‐K3抗凝标本测定,其中27例发生EDTA依赖性假性血小板减少(ED‐TA‐PTCP)。再次采集27例患者的EDTA‐K3和枸橼酸钠抗凝血标本进行测定并制作血涂片,显微镜检观察血小板分布,同时采集指血手工计数血小板。分析27例患者的生化指标,并与50例非EDTA‐PTCP体检健康者结果对比。结果 EDTA抗凝血血小板数明显低于枸橼酸钠抗凝血

  4. Food-dependent exercise-induced anaphylaxis: case report and review of literature%食物依赖运动诱发性过敏反应一例并文献复习

    Institute of Scientific and Technical Information of China (English)

    穆新林; 余洁; 高占成

    2009-01-01

    Objective Food-dependent exercise-induced anaphylaxis (FDEIA) is a kind of food allergic disorder induced by physical exercise. Some FDEIA patients presented severe symptoms which were threat to life. The aim of the article was to improve the recognition of FDEIA among physicians. Methods The clinical data of a patient with FDEIA in our hospital was collected and analyzed, and current related literatures were reviewed. Results An eighteen year-old male was admitted to our hospital because of repeated episodes of urticaria, dyspnea and loss of consciousness for eight months. Each episode was induced by exercise after ingestion of wheat-made food. Symptoms were relieved rapidly by treatment with adrenaline, antihistamines, and/or dexamethasone. Assay of food-specific IgE in serum of the patient showed positive result for shrimp and crab. However, no anaphylaxis was related to the suspected food. Wheat-exercise challenge test showed positive result in the patient, which confirmed the diagnosis of FDEIA. Since then, the patient had avoided wheat food for more than one year, during which period no episode of anaphylaxis was observed, until one day the patient exercised after a diet of wheat food. Conclusions The incidence of FDEIA was rare. Wheat is the common causative food. Food-exercise challenge test is a reliable method for diagnosis of FDEIA. Avoidance of exercise for 4h after eating causative food might be helpful to prevent the occurrence of symptoms in many FDEIA cases. Dietary elimination of causative food ingredients was a reliable method for prophylaxis of FDEIA.%目的 提高临床医师对食物依赖运动诱发性过敏反应(FDEIA)的认识.方法 2007年12月至2009年10月通过对1例FDEIA患者的诊断、治疗经过以及随访结果的分析,结合文献复习,详细阐述该病的病冈、临床表现、诊断方法、治疗及预防方法.结果 患者男,18岁,反复出现荨麻疹、呼吸困难及意识障碍8个月,每次发作均是在进

  5. Spatial dependence of extreme rainfall

    Science.gov (United States)

    Radi, Noor Fadhilah Ahmad; Zakaria, Roslinazairimah; Satari, Siti Zanariah; Azman, Muhammad Az-zuhri

    2017-05-01

    This study aims to model the spatial extreme daily rainfall process using the max-stable model. The max-stable model is used to capture the dependence structure of spatial properties of extreme rainfall. Three models from max-stable are considered namely Smith, Schlather and Brown-Resnick models. The methods are applied on 12 selected rainfall stations in Kelantan, Malaysia. Most of the extreme rainfall data occur during wet season from October to December of 1971 to 2012. This period is chosen to assure the available data is enough to satisfy the assumption of stationarity. The dependence parameters including the range and smoothness, are estimated using composite likelihood approach. Then, the bootstrap approach is applied to generate synthetic extreme rainfall data for all models using the estimated dependence parameters. The goodness of fit between the observed extreme rainfall and the synthetic data is assessed using the composite likelihood information criterion (CLIC). Results show that Schlather model is the best followed by Brown-Resnick and Smith models based on the smallest CLIC's value. Thus, the max-stable model is suitable to be used to model extreme rainfall in Kelantan. The study on spatial dependence in extreme rainfall modelling is important to reduce the uncertainties of the point estimates for the tail index. If the spatial dependency is estimated individually, the uncertainties will be large. Furthermore, in the case of joint return level is of interest, taking into accounts the spatial dependence properties will improve the estimation process.

  6. A Delicate Balance of Different Dependencies

    DEFF Research Database (Denmark)

    Brincker, Benedikte

    of balancing different dependencies. In this perspective, Greenland is the case in extremis. The prospect of Greenland seceding from the Kingdom of Denmark relies upon it becoming embedded in the “international community of sovereign nation states” thus balancing different dependencies ‐ while also...

  7. Resource Abundance and Resource Dependence in China

    NARCIS (Netherlands)

    Ji, K.; Magnus, J.R.; Wang, W.

    2010-01-01

    This paper reconsiders the ‘curse of resources’ hypothesis for the case of China, and distinguishes between resource abundance, resource rents, and resource dependence. Resource abundance and resource rents are shown to be approximately equivalent, and their association with resource dependence vari

  8. Improving the sensitivity of a search for coalescing binary black holes with non-precessing spins in gravitational wave data

    CERN Document Server

    Privitera, Stephen; Ajith, Parameswaran; Cannon, Kipp; Fotopoulos, Nickolas; Frei, Melissa A; Hanna, Chad; Weinstein, Alan J; Whelan, John T

    2014-01-01

    We demonstrate the implementation of a sensitive search pipeline for gravitational waves from coalescing binary black holes whose components have spins aligned with the orbital angular momentum. We study the pipeline recovery of simulated gravitational wave signals from aligned-spin binary black holes added to real detector noise, comparing the pipeline performance with aligned-spin filter templates to the same pipeline with non-spinning filter templates. Our results exploit a three-parameter phenomenological waveform family that models the full inspiral-merger-ringdown coalescence and treats the effect of aligned spins with a single effective spin parameter \\chi. We construct template banks from these waveforms by a stochastic placement method and use these banks as filters in the recently-developed gstlal search pipeline. We measure the observable volume of the analysis pipeline for binary black hole signals with total mass in [15,25] solar masses and \\chi in [0, 0.85]. We find an increase in observable vol...

  9. The NINJA-2 catalog of hybrid post-Newtonian/numerical-relativity waveforms for non-precessing black-hole binaries

    CERN Document Server

    Ajith, P; Brown, Duncan A; Brügmann, Bernd; Buchman, Luisa T; Cadonati, Laura; Campanelli, Manuela; Chu, Tony; Etienne, Zachariah B; Fairhurst, Stephen; Hannam, Mark; Healy, James; Hinder, Ian; Husa, Sascha; Kidder, Lawrence E; Krishnan, Badri; Laguna, Pablo; Liu, Yuk Tung; London, Lionel; Lousto, Carlos O; Lovelace, Geoffrey; MacDonald, Ilana; Marronetti, Pedro; Mohapatra, Satya; Mösta, Philipp; Müller, Doreen; Mundim, Bruno C; Nakano, Hiroyuki; Ohme, Frank; Paschalidis, Vasileios; Pekowsky, Larne; Pollney, Denis; Pfeiffer, Harald P; Ponce, Marcelo; Pürrer, Michael; Reifenberger, George; Reisswig, Christian; Santamaría, Lucía; Scheel, Mark A; Shapiro, Stuart L; Shoemaker, Deirdre; Sopuerta, Carlos F; Sperhake, Ulrich; Szilágyi, Béla; Taylor, Nicholas W; Tichy, Wolfgang; Tsatsin, Petr; Zlochower, Yosef

    2012-01-01

    The Numerical INJection Analysis (NINJA) project is a collaborative effort between members of the numerical relativity and gravitational wave data analysis communities. The purpose of NINJA is to study the sensitivity of existing gravitational-wave search and parameter-estimation algorithms using numerically generated waveforms, and to foster closer collaboration between the numerical relativity and data analysis communities. The first NINJA project used only a small number of injections of short numerical-relativity waveforms, which limited its ability to draw quantitative conclusions. The goal of the NINJA-2 project is to overcome these limitations with long post-Newtonian - numerical relativity hybrid waveforms, large numbers of injections, and the use of real detector data. We report on the submission requirements for the NINJA-2 project and the construction of the waveform catalog. Eight numerical relativity groups have contributed 63 hybrid waveforms consisting of a numerical portion modelling the late ...

  10. Event dependent sampling of recurrent events

    DEFF Research Database (Denmark)

    Kvist, Tine Kajsa; Andersen, Per Kragh; Angst, Jules;

    2010-01-01

    retrospective and prospective disease course histories are used. We examine two methods to correct for the selection depending on which data are used in the analysis. In the first case, the conditional distribution of the process given the pre-selection history is determined. In the second case, an inverse-probability...

  11. Influence of depression and early adverse experiences on illicit drug dependence: a case-control study Influência de depressão e experiências adversas na dependência de drogas ilícitas: um estudo de caso-controle

    Directory of Open Access Journals (Sweden)

    Maristela Ferigolo

    2009-06-01

    Full Text Available OBJECTIVE: The purpose of this study was to investigate the association between depression and illicit drug dependence among a Latin-American population. METHOD: illicit drug dependent patients (n = 137 and controls (n = 274 were interviewed using the Diagnostic Interview for Genetic Studies, in order to detect lifetime and current depressive disorder and illicit (cocaine, cannabis or inhalants substance dependence. A regression analysis was used to estimate the odds ratio for drug dependence according to the diagnosis of depression. RESULTS: The lifetime diagnosis of depression (p = 0.001; OR = 4.9; 95% CI, 1.9-12.7 predicts illegal drugs dependence. Sociodemographic variables such as male gender (p OBJETIVO: O objetivo do presente estudo foi investigar a associação entre depressão e dependência de drogas ilícitas entre a população Latino-Americana. MÉTODO: Indivíduos dependentes de drogas ilícitas (n = 137 e controles (n = 274 foram entrevistados pela Entrevista Diagnóstica para Estudos Genéticos para investigar desordem depressiva corrente, ou durante sua vida, e dependência de drogas ilícitas (cocaína, maconha ou inalantes. Análise de regressão logística foi usada para estimar a razão de chances para dependência de drogas levando em conta o diagnóstico de depressão. RESULTADOS: O diagnóstico de depressão durante sua vida (p = 0,001; OR = 4,9; 95% CI, 1,9-12,7 prediz a dependência de drogas ilícitas. Os dados sociodemográficos sexo masculino (p < 0,001; OR = 36,8; 95% CI, 11,8-114 e situação ocupacional (p = 0,002; OR = 5,0; 95% CI, 1,8-13, e a dependência de álcool (p = 0,01; OR = 3,4; 95% CI, 1,3-8,7 influenciam significativamente a depressão e a dependência de drogas. Ainda, outros fatores importantes que influenciam são ter pais (p = 0,006; OR = 18,9; 95% CI, 2,3-158 ou amigos (p < 0,001; OR = 64,4; 95% CI, 6,5-636 dependentes de drogas ilícitas. CONCLUSÃO: O delineamento utilizado não possibilitou

  12. Loss Aversion with a State-dependent Reference Point

    NARCIS (Netherlands)

    E.G. De Georgi (Enrico); G.T. Post (Thierry)

    2008-01-01

    textabstractThis study investigates loss aversion when the reference point is state-dependent. Using a state-dependent structure, prospects are more attractive if they depend positively on the reference point and are less attractive in case of negative dependence. In addition, the structure is neutr

  13. Effect of donor-acceptor orientation on solvent-dependent three-photon activity in through-space charge-transfer systems--case study of [2,2]-paracyclophane derivatives.

    Science.gov (United States)

    Alam, Md Mehboob; Chattopadhyaya, Mausumi; Chakrabarti, Swapan; Ruud, Kenneth

    2013-10-28

    We study the effect of donor-acceptor orientation on solvent-dependent three-photon transition probabilities (δ(3PA)) of representative through-space charge-transfer (TSCT) systems, namely, doubly positively charged [2,2]-paracyclophane derivatives. Our cubic response calculations reveal that the value of δ(3PA) may be as high as 10(6) a.u., which can further be increased by a specific orientation of the donor-acceptor moieties. To explain the origin of the solvent cum orientation dependency of δ(3PA), we have calculated different three-photon tensor components using a two-state model, noting that only a few tensor elements contribute significantly to the overall δ(3PA) value. We show that this dependence is due to the large dipole moment difference between the ground and excited states of the systems. The dominance of a few tensor elements indicates a synergistic involvement of π-conjugation and TSCT in the large δ(3PA) of these systems.

  14. LDF (Lag Dependence Functions)

    DEFF Research Database (Denmark)

    2000-01-01

    LDF (Lag Dependence Functions) is an S-PLUS library for identification of non-linear dependencies in univariate time series. The methods can be considered generalizations of the tools applicable for linear time series.......LDF (Lag Dependence Functions) is an S-PLUS library for identification of non-linear dependencies in univariate time series. The methods can be considered generalizations of the tools applicable for linear time series....

  15. [Evaluating tobacco dependance].

    Science.gov (United States)

    Etter, Jean-François

    2006-11-29

    Good science needs good measurement instruments, and this is also true for the study of tobacco dependence. In this paper, we present and criticize the most frequently used instrument, the Fagerström Test for Nicotine Dependence. This test, published 28 years ago, does not reflect current definitions of dependence. Several alternative approaches to the measurement of tobacco dependence are discussed, and more recent instruments are presented.

  16. LDF (Lag Dependence Functions)

    DEFF Research Database (Denmark)

    2000-01-01

    LDF (Lag Dependence Functions) is an S-PLUS library for identification of non-linear dependencies in univariate time series. The methods can be considered generalizations of the tools applicable for linear time series.......LDF (Lag Dependence Functions) is an S-PLUS library for identification of non-linear dependencies in univariate time series. The methods can be considered generalizations of the tools applicable for linear time series....

  17. Hierarchies in Dependence Logic

    CERN Document Server

    Durand, Arnaud

    2011-01-01

    We study fragments of dependence logic defined either by restricting the number k of universal quantifiers or the width of dependence atoms in formulas. We find the sublogics of existential second-order logic corresponding to these fragments of dependence logic. We also show that these both ways of defining fragments of dependence logic give rise to a hierarchy in expressive power with respect to k.

  18. [Dependence disorders in psychopathology].

    Science.gov (United States)

    Fernandez, L; Sztulman, H

    1999-01-01

    Research concerning the psychopathological aspects of dependence implicates a wide range of behaviors reassembled under the term of "dependence behaviors": sexual, medical, alcoholic and tobacco dependencies. Speech samples of dependent subjects show that encountering the object of dependence (product, element, ...) introduces a particular form of organized psychological processes. According to several authors, psychopathological dependence can be attributed to: early personality development; failures in the separation-individuation processes; disorders in mother-infant interactions; and a deficit in the psychological functioning of the subjects. For psychopathology, the dependence cannot be reduced to physiological dependence on the product but is understood rather in terms of a complex process indicative of either specific or non-specific suffering which is addressed by abused substance that represents a solution--the effects of which constitute the addictive process. Understanding this process requires an analysis of the psychopathological dependence from a triple meta-psychological viewpoint (topographical, dynamic, economic). Such analysis allows for a psychoanalytical theoretical interpretation of dependence based on three models: pleasure, narcissism and stress reduction. At the same time, the analysis extends the examination of psychopathological dependence towards issues concerning the body. Such body issues are critically placed between the biological and the psychological processes.

  19. Benzodiazepine use, abuse, and dependence.

    Science.gov (United States)

    O'brien, Charles P

    2005-01-01

    Although benzodiazepines are invaluable in the treatment of anxiety disorders, they have some potential for abuse and may cause dependence or addiction. It is important to distinguish between addiction to and normal physical dependence on benzodiazepines. Intentional abusers of benzodiazepines usually have other substance abuse problems. Benzodiazepines are usually a secondary drug of abuse-used mainly to augment the high received from another drug or to offset the adverse effects of other drugs. Few cases of addiction arise from legitimate use of benzodiazepines. Pharmacologic dependence, a predictable and natural adaptation of a body system long accustomed to the presence of a drug, may occur in patients taking therapeutic doses of benzodiazepines. However, this dependence, which generally manifests itself in withdrawal symptoms upon the abrupt discontinuation of the medication, may be controlled and ended through dose tapering, medication switching, and/or medication augmentation. Due to the chronic nature of anxiety, long-term low-dose benzodiazepine treatment may be necessary for some patients; this continuation of treatment should not be considered abuse or addiction.

  20. Definition of a Dependent Child

    CERN Multimedia

    Human Resources Department

    2005-01-01

    The Department of Human Resources wishes to remind members of the personnel that, under the provisions of § 6 of Administrative Circular No. 5 “Dependent child”, in the case of a child over 18 years of age the status of dependent child comes to an end once a course of studies is completed. Consequently, the payment of the dependent child allowance and the child's membership of the CERN Health Insurance Scheme terminate with effect from the last day of the month in which the course of study concerned ends. In this connection, members of the personnel are reminded that children who are no longer dependent according to the Staff Rules and Regulations and who are less than 26 years of age can nevertheless opt for membership of the normal health insurance under the terms and conditions laid down in the CERN Health Insurance Rules. The Department of Human Resources also wishes to remind members of the personnel that, pursuant to Article R IV 1.17 of the Staff Regulations, a member of the personnel is requ...

  1. Combination of Traditional Chinese and Western Medicine Treating Blood-deficiency Wind-attack Pattern of Hormone Dependence Dermatitis:Clinical Observation of 39 Cases%中西医结合治疗血虚风燥型激素依赖性皮炎39例临床观察

    Institute of Scientific and Technical Information of China (English)

    丁晓华; 倪红; 侯小东

    2013-01-01

      目的:观察自拟养血润肤湿敷剂合橄榄油治疗血虚风燥型激素依赖性皮炎的疗效.方法:选取笔者所在医院血虚风燥型激素依赖性皮炎39例患者为研究对象,口服抗组胺药物氯雷他定及复方丹参片,中药自拟养血润肤湿敷剂水煎后冷却湿敷,敷后外搽橄榄油,治疗30 d后观察疗效并进行分析.结果:治愈25例,显效7例,好转3例,无效4例.有效35例,有效率89.74%.结论:采用口服抗组胺药物氯雷他定及复方丹参片,外敷自拟养血润肤湿敷剂合橄榄油,中西医结合治疗血虚风燥型激素依赖性皮炎取得满意疗效.%Objective:Observation of clinical effect of nourishing emollients hydropathic compress with olive oil treating blood-deficiency wind-attack pattern of hormone dependent dermatitis.Methods:Oral antihistamine loratadine and compound Danshen tablets,traditional Chinese medicine decoction for nourishing emollients hydropathic compress decocted for cooling wet compress,deposited after the external use of olive oil,treating blood-deficiency wind-attack pattern of hormone dependence dermatitis:report of 39 cases,30 days later,the therapeutic effects were observed and analyzed.Results:25 cases were cured, 7 cases were markedly effective,3 cases improved,4 cases are invalid.Effective in 35 cases,the efficiency of 89.74%.Conclusion:Using oral antihistamine loratadine and compound Danshen tablets,external application of self-made nourishing emollients hydropathic compress with olive oil,combination of traditional chinese and western medicine treating blood-deficiency wind-attack pattern of hormone dependence dermatitis obtains satisfaction curative effect.

  2. Case Report Case Report

    African Journals Online (AJOL)

    User

    2013-03-26

    Mar 26, 2013 ... at the time of diagnosis try various complementary and and palliation. ... c Medicine and Palliative Cancer Care: A Case Report ... us complementary and alternative therapies for treatment about the .... in nature. Upper GI ...

  3. Is parasite load dependent on host aggregation size? The case of the greater mouse-eared bat Myotis myotis (Mammalia: Chiroptera) and its parasitic mite Spinturnix myoti (Acari: Gamasida).

    Science.gov (United States)

    Postawa, Tomasz; Szubert-Kruszyńska, Agnieszka

    2014-05-01

    The risk of parasite infection grows with the size of host aggregations, which, in turn, may also depend on host sex and age and the quality of environmental resources. Herein, we studied the relationship between ectoparasitic infections with the wing mite (Spinturnix myoti) and the size of the breeding colonies, sex, age, and body condition index (BCI) of its host, the greater mouse-eared bat (Myotis myotis). The influence of environmental quality in the Carpathian Mountains (Poland) was also examined. We found significant differences in mite abundance and BCI between different breeding aggregations of the greater mouse-eared bat and also between the host sex/age categories. The most heavily infected bats were adult M. myotis females, while young males appeared to be the least infected. The BCI differed significantly between the sexes in young bats (males had a higher BCI than females) and also between colonies. No significant differences in the BCI were found for adult females. We did not find any relationship between the infestation rate of M. myotis, their colony size, the quality of environmental resources (percentage of forest cover around the colony), or the BCI. The prevalence of the various developmental stages of the mites did not differ between the host sex/age categories; however, differences were found in the sex ratios of deutonymphs and adult mites between adult M. myotis females. We predict that parasite load may not be dependent on colony size itself, but mainly on microclimatic factors, which are in turn directly correlated with colony size.

  4. Endoscopic case

    Directory of Open Access Journals (Sweden)

    Fernando Pereira

    2017-01-01

    Full Text Available We present the case of a ten-year-old female patient referred to Gastroenterolgy consultation for abdominal pain and cramping, usually worse after eating, recurring diarrhoea, hypochromic and microcytic anaemia with low serum iron and ferritin levels. Moderate to severe Crohn’s disease of the terminal ileum e right colon (L3 was diagnosed, based on endoscopic image and biopsy. The patient was treated with prednisone and azathioprine, but after one year of treatment she was steroids dependent and treatment was switched to infliximab. One year after beginning this treatment, the patient achieved remission (clinical and laboratorial parameters. A control colonoscopy showed mucosal healing with scars and deformation with stenosis of ileocecal valve (Figures 1-2. Surgical intervention will be probably necessary in near future.

  5. Systems dependability assessment

    CERN Document Server

    Aubry, Jean-François

    2015-01-01

    Presents recent developments of probabilistic assessment of systems dependability based on stochastic models, including graph theory, finite state automaton and language theory, for both dynamic and hybrid contexts.

  6. Velocity dependence of friction of confined polymers

    DEFF Research Database (Denmark)

    Sivebæk, Ion Marius; Samoilov, V.N.; Persson, B.N.J.

    2009-01-01

    We present molecular dynamics friction calculations for confined hydrocarbon solids with molecular lengths from 20 to 1400 carbon atoms. Two cases are considered: (a) polymer sliding against a hard substrate, and (b) polymer sliding on polymer. We discuss the velocity dependence of the frictional...... cases the frictional shear stress increases monotonically with the sliding velocity. For polymer sliding on polymer [case (b)] the friction is much larger, and the velocity dependence is more complex. For hydrocarbons with molecular lengths from 60 to 140 C-atoms, the number of monolayers of lubricant...... shows no dependence on the sliding velocity, and for the shortest hydrocarbon (20 C-atoms) the frictional shear stress increases nearly linearly with the sliding velocity....

  7. Distance dependence of fluorescence resonance energy transfer

    Indian Academy of Sciences (India)

    R S Swathi; K L Sebastian

    2009-09-01

    Deviations from the usual -6 dependence of the rate of fluorescence resonance energy transfer (FRET) on the distance between the donor and the acceptor have been a common scenario in the recent times. In this paper, we present a critical analysis of the distance dependence of FRET, and try to illustrate the non--6 type behaviour of the rate for the case of transfer from a localized electronic excitation on the donor, a dye molecule to three different energy acceptors with delocalized electronic excitations namely, graphene, a two-dimensional semiconducting sheet and the case of such a semiconducting sheet rolled to obtain a nanotube. We use simple analytic models to understand the distance dependence in each case.

  8. Energy-dependent variability from accretion flows

    OpenAIRE

    Zdziarski, Andrzej A.

    2005-01-01

    We develop a formalism to calculate energy-dependent fractional variability (rms) in accretion flows. We consider rms spectra resulting from radial dependencies of the level of local variability (as expected from propagation of disturbances in accretion flows) assuming the constant shape of the spectrum emitted at a given radius. We consider the cases when the variability of the flow is either coherent or incoherent between different radial zones. As example local emission, we consider blackb...

  9. Dependent Probability Spaces

    Science.gov (United States)

    Edwards, William F.; Shiflett, Ray C.; Shultz, Harris

    2008-01-01

    The mathematical model used to describe independence between two events in probability has a non-intuitive consequence called dependent spaces. The paper begins with a very brief history of the development of probability, then defines dependent spaces, and reviews what is known about finite spaces with uniform probability. The study of finite…

  10. Decisions Concerning Directional Dependence

    Science.gov (United States)

    von Eye, Alexander; DeShon, Richard P.

    2012-01-01

    In this rejoinder, von Eye and DeShon discuss the decision strategies proposed in their original article ("Directional Dependence in Developmental Research," this issue), as well as the ones proposed by the authors of the commentary (Pornprasertmanit and Little, "Determining Directional Dependency in Causal Associations," this issue). In addition,…

  11. The Politics of Dependence

    DEFF Research Database (Denmark)

    Cockburn, Patrick Joseph

    The central claim of this book is that thinking about ‘dependence’ should be at the core of political theory principally because it helps us to think about issues of economic justice. Unlike political theories that either condemn or celebrate dependence, the book argues that dependence is an ines...

  12. Multidimensional extremal dependence coefficients

    OpenAIRE

    2017-01-01

    Extreme values modeling has attracting the attention of researchers in diverse areas such as the environment, engineering, or finance. Multivariate extreme value distributions are particularly suitable to model the tails of multidimensional phenomena. The analysis of the dependence among multivariate maxima is useful to evaluate risk. Here we present new multivariate extreme value models, as well as, coefficients to assess multivariate extremal dependence.

  13. Dependence and Fundamentality

    Directory of Open Access Journals (Sweden)

    Justin Zylstra

    2014-12-01

    Full Text Available I argue that dependence is neither necessary nor sufficient for relative fundamentality. I then introduce the notion of 'likeness in nature' and provide an account of relative fundamentality in terms of it and the notion of dependence. Finally, I discuss some puzzles that arise in Aristotle's Categories, to which the theory developed is applied.

  14. Gradle dependency management

    CERN Document Server

    Ikkink, Hubert Klein

    2015-01-01

    If you work on Java projects, use Gradle as a build automation tool, and you use dependencies in your project, this is the book for you. Additionally, if you want to deploy your project artifacts as dependencies for other developers using Gradle, you've found the right book.

  15. Adam Smith and dependency.

    Science.gov (United States)

    Ozler, Sule

    2012-06-01

    The focus of this paper is the works and life of Adam Smith, who is widely recognized as the father and founder of contemporary economics. Latent content analysis is applied to his seminal text in economics, An Inquiry into the Nature and Causes of the Wealth of Nations (1776). The results reveal that Smith considers dependence on others a problem and sees the solution to this problem in impersonalized interdependence. In addition, his views on social dependency and personal dependency, reflected in his Lectures on Jurisprudence (1963) and The Theory of Moral Sentiments (1759), are analyzed. This analysis suggests a central tension between dependence and independence in Smith's writings. The personal dependency patterns he exhibited in his life, which also suggest a tension between dependence and independence, are identified through a reading of his biographies. Based on insights from psychoanalytic literature, this paper proposes that developing the ideas in the Wealth of Nations was part of Smith's creative solution to this tension. In particular, his solution to one individual's dependence on another was through a system of impersonalized interdependence. In other words, Smith defended against his personal dependence through his economic theorizing.

  16. Does melissa officinalis cause withdrawal or dependence?

    Science.gov (United States)

    Demirci, Kadir; Akgönül, Mehmet; Demirdaş, Arif; Akpınar, Abdullah

    2015-02-01

    Melissa officinalis is a medical and aromatic plant that is used for its hypnotic, sedative, and spasmolytic effects. This report presents a case study of30-year-old patient who was admitted to an emergency department with restlessness, tremor, distractibility, and sweating following a discontinuation of Melissa officinalis consumption. In this case, withdrawal symptoms may be related to the dependence effect caused by long-term use of Melissa officinalis. Although Melissa officinalis, a plant, is preferred by many patients as an alternative to pharmaceutical drugs, patients should be made aware that it may have a risk of dependency and can lead to withdrawal symptoms.

  17. 痔出血并乙二胺四乙酸依赖性假性血小板减少症一例%Hemorrhoid Bleeding Complicated by EDTA-dependent Pseudothrombocytopenia: Report of One Case

    Institute of Scientific and Technical Information of China (English)

    闵春明; 郝志楠; 尹德成

    2011-01-01

    @@ 乙二胺四乙酸盐(ethylenediamine telraacetic acid,EDTA)是被国际血液学标准化委员(ICSH)认定对血细胞影响较小的血液抗凝剂,作为较理想的血常规抗凝剂被临床广泛使用,但EDTA可以导致个别患者血液中的血小板发生聚集,引起EDTA依赖性假性血小板减少症(EDTA-dependent pseudothrombocytopenia,EDTA-PTCP)[1],并且与抗凝时间有关,即抗凝时间越长,血小板聚集现象越严重,血小板数量越低[2].目前,国内外开始广泛关注假性血小板减少症,笔者近期临床工作中遇到1例痔出血并EDTA-PTCP行手术治疗患者,现将诊疗经过及体会总结如下.

  18. Maintainence Treatment of Opioid Dependence with Tramadol.

    Science.gov (United States)

    Sarkar, Siddharth; Varshney, Mohit; Patil, Vaibhav; Lal, Rakesh

    2017-08-01

    Although tramadol has been used in the management of acute withdrawal in patients with opioid dependence, its use for maintenance treatment as a harm reduction approach has not been assessed systematically. This case series describes patients with opioid dependence who were treated with tramadol for long-term maintenance. Patients with opioid dependence who received treatment at the National Drug Dependence Treatment Centre of All India Institute of Medical Sciences, New Delhi, were included in the study. Patients who received at least 6 months of tramadol and had follow-up adherence of more than 80% were included in the case series. A total of 25 cases were included, all of whom were males. The types of opioids being taken at the time of initiation of tramadol were natural opiates (poppy husk and raw opium), followed by heroin. The median dose of tramadol at initiation and maintenance was 300 mg/day. Nineteen patients were able to achieve complete abstinence to other opiates on tramadol. Tramadol may be an effective option in the long-term management of patients with opioid dependence. Further studies are required for establishing the efficacy of tramadol for agonist management of patients with opioid dependence.

  19. Lomotil (diphenoxylate dependence in India

    Directory of Open Access Journals (Sweden)

    Aseem Mehra

    2013-01-01

    Full Text Available Background: Lomotil (diphenoxylate atropine combination has been in use as an antidiarrhoeal agent. Due to presence of opioid (diphenoxylate, there are chances of abuse. The reports of abuse of lomotil have been few in published literature. This chart review aimed to evaluate the characteristics of patients with dependence on lomotil coming to our centre. Materials and Methods: This retrospective chart review was conducted at the Drug De-addiction and Treatment Centre of PGIMER, Chandigarh, India. The records of patients who had presented to the centre with dependence on Lomotil in the last five years were identified, and clinical details were extracted from the records. Results: We identified 41 patients who had presented to our centre with dependence upon lomotil as the primary substance of abuse. The cases were typically married and employed males, educated up to 10 th grade, belonging to a rural Sikh extended or joint family. Most of the patients had taken other opioids too. The number of tablets taken in a day varied from 3- to 250 (median 25. The reasons of initiation were to relieve withdrawals, as a cheap substitute opioid, curiosity, and on suggestion of friends. Conclusion: Lomotil is a medication with a potential of abuse and regulatory controls are required to prevent escalation of misuse of this easily available prescription drug. Lomotil (diphenoxylate and atropine combination has been used since a long time as an anti-diarrheal agent. Reports of abuse of diphenoxylate had surfaced. We present a series of 41 cases of opioid dependence presenting with the use of the diphenoxylate as the primary substance. The cases were typically married and employed males, educated up to 10 th grade, belonging to a rural Sikh extended or joint family. Most of the patients had taken other opioids too. The number of tablets taken in a day varied from 3 to 250 (median 25. The reasons of initiation of diphenoxylate were to relieve withdrawals, as a

  20. Visual dependence and BPPV.

    Science.gov (United States)

    Agarwal, K; Bronstein, A M; Faldon, M E; Mandalà, M; Murray, K; Silove, Y

    2012-06-01

    The increased visual dependence noted in some vestibular patients may be secondary to their vertigo. We examine whether a single, brief vertigo attack, such as in benign paroxysmal positional vertigo (BPPV), modifies visual dependency. Visual dependency was measured before and after the Hallpike manoeuvre with (a) the Rod and Frame and the Rod and Disc techniques whilst seated and (b) the postural sway induced by visual roll-motion stimulation. Three subject groups were studied: 20 patients with BPPV (history and positive Hallpike manoeuvre; PosH group), 20 control patients (history of BPPV but negative Hallpike manoeuvre; NegH group) and 20 normal controls. Our findings show that while both patient groups showed enhanced visual dependency, the PosH and the normal control group decreased visual dependency on repetition of the visual tasks after the Hallpike manoeuvre. NegH patients differed from PosH patients in that their high visual dependency did not diminish on repetition of the visual stimuli; they scored higher on the situational characteristic questionnaire ('visual vertigo' symptoms) and showed higher incidence of migraine. We conclude that long term vestibular symptoms increase visual dependence but a single BPPV attack does not increase it further. Repetitive visual motion stimulation induces adaptation in visual dependence in peripheral vestibular disorders such as BPPV. A positional form of vestibular migraine may underlie the symptoms of some patients with a history of BPPV but negative Hallpike manoeuvre. The finding that they have non adaptable increased visual dependency may explain visuo-vestibular symptoms in this group and, perhaps more widely, in patients with migraine.

  1. Epidemiology of pyridoxine dependent seizures in the Netherlands.

    NARCIS (Netherlands)

    Been, J.V.; Bok, L.A.; Andriessen, P.; Renier, W.O.

    2005-01-01

    BACKGROUND: Pyridoxine dependent epilepsy is a rare cause of seizures in childhood. The diagnosis is made on clinical criteria, that in many cases are never met. Therefore, epidemiological data on pyridoxine dependency are scarce. AIMS: To study the epidemiology of pyridoxine dependent epilepsy in t

  2. Improving Loop Dependence Analysis

    DEFF Research Database (Denmark)

    Jensen, Nicklas Bo; Karlsson, Sven

    2017-01-01

    Programmers can no longer depend on new processors to have significantly improved single-thread performance. Instead, gains have to come from other sources such as the compiler and its optimization passes. Advanced passes make use of information on the dependencies related to loops. We improve...... the quality of that information by reusing the information given by the programmer for parallelization. We have implemented a prototype based on GCC into which we also add a new optimization pass. Our approach improves the amount of correctly classified dependencies resulting in 46% average improvement...

  3. Dependencies in Formal Mathematics

    CERN Document Server

    Alama, Jesse; Urban, Josef

    2011-01-01

    Dependencies in formal mathematical texts, large coherent formal libraries and proof assistants are introduced as an emerging research topic, analyzed from foundational, semantic, computational, and pragmatic perspectives, and put to practical use in computer-assisted mathematics. Two different approaches to dependency computation are implemented over two major proof assistants with different type disciplines, and a large-scale experimental comparison is provided based on large Coq and Mizar formal libraries. Apart from theoretical discussions, importance of dependency analysis for advanced automation of computer-assisted reasoning, and for efficient proof analysis and theory refactoring in substantial mathematical domains are experimentally demonstrated.

  4. Security of Dependable Systems

    DEFF Research Database (Denmark)

    Ahmed, Naveed; Jensen, Christian D.

    2011-01-01

    Security and dependability are crucial for designing trustworthy systems. The approach “security as an add-on” is not satisfactory, yet the integration of security in the development process is still an open problem. Especially, a common framework for specifying dependability and security is very...... much needed. There are many pressing challenges however; here, we address some of them. Firstly, security for dependable systems is a broad concept and traditional view of security, e.g., in terms of confidentiality, integrity and availability, does not suffice. Secondly, a clear definition of security...... in the dependability context is not agreed upon. Thirdly, security attacks cannot be modeled as a stochastic process, because the adversary’s strategy is often carefully planned. In this chapter, we explore these challenges and provide some directions toward their solutions....

  5. Case Based Reasoning: Case Representation Methodologies

    Directory of Open Access Journals (Sweden)

    Shaker H. El-Sappagh

    2015-11-01

    Full Text Available Case Based Reasoning (CBR is an important technique in artificial intelligence, which has been applied to various kinds of problems in a wide range of domains. Selecting case representation formalism is critical for the proper operation of the overall CBR system. In this paper, we survey and evaluate all of the existing case representation methodologies. Moreover, the case retrieval and future challenges for effective CBR are explained. Case representation methods are grouped in to knowledge-intensive approaches and traditional approaches. The first group overweight the second one. The first methods depend on ontology and enhance all CBR processes including case representation, retrieval, storage, and adaptation. By using a proposed set of qualitative metrics, the existing methods based on ontology for case representation are studied and evaluated in details. All these systems have limitations. No approach exceeds 53% of the specified metrics. The results of the survey explain the current limitations of CBR systems. It shows that ontology usage in case representation needs improvements to achieve semantic representation and semantic retrieval in CBR system.

  6. Apache Maven dependency management

    CERN Document Server

    Lalou, Jonathan

    2013-01-01

    An easy-to-follow, tutorial-based guide with chapters progressing from basic to advanced dependency management.If you are working with Java or Java EE projects and you want to take advantage of Maven dependency management, then this book is ideal for you. This book is also particularly useful if you are a developer or an architect. You should be well versed with Maven and its basic functionalities if you wish to get the most out of this book.

  7. Saving, dependency and development.

    Science.gov (United States)

    Kelley, A C; Schmidt, R M

    1996-01-01

    This study examines the impact of dependency on savings between 65 less developed countries (LDCs) and 23 developed countries over time and cross-sectionally since 1960. The study tests a modified Leff model and the Mason life-cycle framework. Empirical estimates address potential simultaneity between savings and output growth. The price indices of Summers and Heston are used because each country's national accounts are converted from nominal into purchasing-power variables. This eliminates the problems with using exchange rates which vary systematically by level of development with a "true" index of purchasing power. Savings (S/Y) is the percentage share of gross national saving in gross domestic product. Ygr is the growth of per capita income. Y/N gr is the growth in the per capita gross domestic product. Analysis is based on ordinary least squares (OLS) and two-stage least squares techniques, treatment for heteroscedascity, aggregation periods, several definitions of savings, different country samples, and aged dependency and youth dependency. Findings support the Mason variable-growth life-cycle framework that shows that changes in demographic factors accounted for a large part of savings. The relationships in the modified Leff-type model were weak, with the exception of the mildly negative youth and elderly dependency impact in the 1980s. The rate of growth of youth dependency was negative and significant in all cross-sections for the full sample, all panel estimates for both LDCs and the full sample, and in the 1980s for LDCs. In the OLS model, life-cycle effects were weaker, but direct dependency effects were stronger. S/Y over time became slightly more sensitive to changes in life cycle impacts but less sensitive to youth dependency. Demography's impact on savings over time is attributed to the increase in the pace of youth dependency decline and secondarily to its increasing sensitivity to life-cycle effects.

  8. Dose-dependent galactorrhea with quetiapine

    OpenAIRE

    Sethi, Sujata; Sharma, Manisha; Malik, Amit

    2010-01-01

    Quetiapine is an atypical antipsychotic agent with minimal propensity to induce hyperprolactinemia in standard therapeutic dosages. Despite that quetiapine is considered to be a prolactin-sparing atypical antipsychotic, hyperprolactinemia with related side effects may rarely be encountered in susceptible individuals. We report a case of quetiapine-induced hyperprolactinemia and galactorrhea in an adult female, which was dose-dependent.

  9. Anticonvulsants for cocaine dependence.

    Science.gov (United States)

    Minozzi, Silvia; Cinquini, Michela; Amato, Laura; Davoli, Marina; Farrell, Michael F; Pani, Pier Paolo; Vecchi, Simona

    2015-04-17

    Cocaine dependence is a major public health problem that is characterised by recidivism and a host of medical and psychosocial complications. Although effective pharmacotherapy is available for alcohol and heroin dependence, none is currently available for cocaine dependence, despite two decades of clinical trials primarily involving antidepressant, anticonvulsivant and dopaminergic medications. Extensive consideration has been given to optimal pharmacological approaches to the treatment of individuals with cocaine dependence, and both dopamine antagonists and agonists have been considered. Anticonvulsants have been candidates for use in the treatment of addiction based on the hypothesis that seizure kindling-like mechanisms contribute to addiction. To evaluate the efficacy and safety of anticonvulsants for individuals with cocaine dependence. We searched the Cochrane Drugs and Alcohol Group Trials Register (June 2014), the Cochrane Central Register of Controlled Trials (CENTRAL) (2014, Issue 6), MEDLINE (1966 to June 2014), EMBASE (1988 to June 2014), the Cumulative Index to Nursing and Allied Health Literature (CINAHL) (1982 to June 2014), Web of Science (1991 to June 2014) and the reference lists of eligible articles. All randomised controlled trials and controlled clinical trials that focus on the use of anticonvulsant medications to treat individuals with cocaine dependence. We used the standard methodological procedures expected by The Cochrane Collaboration. We included a total of 20 studies with 2068 participants. We studied the anticonvulsant drugs carbamazepine, gabapentin, lamotrigine, phenytoin, tiagabine, topiramate and vigabatrin. All studies compared anticonvulsants versus placebo. Only one study had one arm by which the anticonvulsant was compared with the antidepressant desipramine. Upon comparison of anticonvulsant versus placebo, we found no significant differences for any of the efficacy and safety measures. Dropouts: risk ratio (RR) 0.95, 95

  10. State Dependence in Unemployment

    DEFF Research Database (Denmark)

    Ahmad, Nisar

    2014-01-01

    This study examines the extent state dependence among unemployed immigrants in a dynamic discrete choice framework. Three alternative methodologies are employed to control for the problem of the initial condition. The empirical findings show that there is a considerable correlation between the un...

  11. Path dependence and creation

    DEFF Research Database (Denmark)

    Garud, Raghu; Karnøe, Peter

    the place of agency in these theories that take history so seriously. In the end, they are as interested in path creation and destruction as they are in path dependence. This book is compiled of both theoretical and empirical writing. It shows relatively well-known industries such as the automobile...

  12. The Alpino Dependency Treebank

    NARCIS (Netherlands)

    van der Beek, L; Bouma, G; Malouf, R; van Noord, G; Theune, M; Nijholt, A; Hondorp, H

    2002-01-01

    In this paper we present the Alpino Dependency Treebank and the tools that we have developed to facilitate the annotation process. Annotation typically starts with parsing a sentence with the Alpino parser, a wide coverage parser of Dutch text, The number of parses that is generated is reduced throu

  13. Reference-Dependent Sympathy

    Science.gov (United States)

    Small, Deborah A.

    2010-01-01

    Natural disasters and other traumatic events often draw a greater charitable response than do ongoing misfortunes, even those that may cause even more widespread misery, such as famine or malaria. Why is the response disproportionate to need? The notion of reference dependence critical to Prospect Theory (Kahneman & Tversky, 1979) maintains that…

  14. Reference-Dependent Sympathy

    Science.gov (United States)

    Small, Deborah A.

    2010-01-01

    Natural disasters and other traumatic events often draw a greater charitable response than do ongoing misfortunes, even those that may cause even more widespread misery, such as famine or malaria. Why is the response disproportionate to need? The notion of reference dependence critical to Prospect Theory (Kahneman & Tversky, 1979) maintains that…

  15. Aspects, Dependencies, and Interactions

    NARCIS (Netherlands)

    Chitchyan, R; Fabry, J.; Bergmans, Lodewijk; Südholt, M.; Consel, C.

    2007-01-01

    For Aspect-Oriented Software Development (AOSD) the topic of Aspects, Dependencies and Interactions is of high importance across the whole range of development activities – from requirements engineering through to language design. Aspect interactions must be adequately addressed all across the softw

  16. State Dependence in Unemployment

    DEFF Research Database (Denmark)

    Ahmad, Nisar

    2014-01-01

    This study examines the extent state dependence among unemployed immigrants in a dynamic discrete choice framework. Three alternative methodologies are employed to control for the problem of the initial condition. The empirical findings show that there is a considerable correlation between...

  17. Frequency dependence of the subharmonic Shapiro steps.

    Science.gov (United States)

    Tekić, Jasmina; Ivić, Zoran

    2011-05-01

    Frequency dependence of the subharmonic Shapiro steps has been studied in the ac driven overdamped Frenkel-Kontorova model with deformable substrate potential. As potential gets deformed, in addition to the harmonic steps, subharmonic steps appear in the number and size that increase as the frequency of the external force increases. It was found that size of both harmonic and subharmonic steps strongly depend on the frequency where in the high-amplitude limit oscillatory dependence appears. When expressed as a function of period these oscillations of the step size with frequency have the same form as the oscillations of the step size with amplitude. Deformation of the potential has strong influence on these oscillations, and as in the case of amplitude dependence, with the increase of deformation, the same three distinctive types of behavior have been classified.

  18. Case series

    African Journals Online (AJOL)

    abp

    30 janv. 2017 ... Clinical symptoms were mainly cough (32.8% of cases), dyspnea (23.7% of ... of cases, sarcomas in 7.8% of cases, renal cancers in 5.2% of cases, bladder ..... Prognosis of osteosarcoma with pulmonary metastases at initial.

  19. Velocity Dependence of Friction of Confined Hydrocarbons

    DEFF Research Database (Denmark)

    Sivebæk, Ion Marius; Samoilov, Vladimir N.; Persson, Bo N. J.

    2010-01-01

    We present molecular dynamics friction calculations for confined hydrocarbon “polymer” solids with molecular lengths from 20 to 1400 carbon atoms. Two cases are considered: (a) polymer sliding against a hard substrate and (b) polymer sliding on polymer. We discuss the velocity dependence of the f......We present molecular dynamics friction calculations for confined hydrocarbon “polymer” solids with molecular lengths from 20 to 1400 carbon atoms. Two cases are considered: (a) polymer sliding against a hard substrate and (b) polymer sliding on polymer. We discuss the velocity dependence...... in the polymer film is always close to the thermostat temperature. In the first setup (a), for hydrocarbons with molecular lengths from 60 to 1400 carbon atoms, the shear stresses are nearly independent of molecular length, but for the shortest hydrocarbon C20H42 the frictional shear stress is lower. In all...... cases the frictional shear stress increases monotonically with the sliding velocity. For polymer sliding on polymer (case b) the friction is much larger, and the velocity dependence is more complex. For hydrocarbons with molecular lengths from 60 to 140 C atoms, the number of monolayers of lubricant...

  20. Time dependent mean-field games

    KAUST Repository

    Gomes, Diogo A.

    2014-01-06

    We consider time dependent mean-field games (MFG) with a local power-like dependence on the measure and Hamiltonians satisfying both sub and superquadratic growth conditions. We establish existence of smooth solutions under a certain set of conditions depending both on the growth of the Hamiltonian as well as on the dimension. In the subquadratic case this is done by combining a Gagliardo-Nirenberg type of argument with a new class of polynomial estimates for solutions of the Fokker-Planck equation in terms of LrLp- norms of DpH. These techniques do not apply to the superquadratic case. In this setting we recur to a delicate argument that combines the non-linear adjoint method with polynomial estimates for solutions of the Fokker-Planck equation in terms of L1L1-norms of DpH. Concerning the subquadratic case, we substantially improve and extend the results previously obtained. Furthermore, to the best of our knowledge, the superquadratic case has not been addressed in the literature yet. In fact, it is likely that our estimates may also add to the current understanding of Hamilton-Jacobi equations with superquadratic Hamiltonians.

  1. 基于辅助阵元的方位依赖幅相误差最大似然自校正:针对确定信号模型%Maximum likelihood self-calibration for direction-dependent gain-phase errors with carry-on instrumental sensors:case of deterministic signal model

    Institute of Scientific and Technical Information of China (English)

    王鼎; 潘苗; 吴瑛

    2011-01-01

    Aim at the self-calibration of direction-dependent gm-phase errors in case of deterministic signal model, the maximum likelihood method(MLM) for calibrating the direction-dependent gain-phase errors with carry-on instrumental sensors was presented. In order to maximize the high-dimensional nonlinear cost function appearing in the MLM, an improved alternative projection iteration algorithm, which could optimize the azimuths and direc6on-dependent gain-phase errors was proposed. The closed-form expressions of the Cramér-Rao bound(CRB) for azimuths and gain-phase errors were derived. Simulation experiments show the effectiveness and advantage of the novel method.%针对确定信号模型条件下方位依赖幅相误差的自校正问题,给出了一种基于辅助阵元的方位依赖幅相误差最大似然自校正方法;针对最大似然估计器中出现的高维非线性优化问题,推导了一种改进型交替投影迭代算法,从而实现了信号方位和方位依赖幅相误差的优化计算.此外,还推导了信号方位和方位依赖幅相误差的无偏克拉美罗界(CRB).仿真实验结果验证了新方法的有效性和优越性.

  2. Petroleum Dependency: The Case to Replace the Internal Combustion Engine

    Science.gov (United States)

    2015-02-17

    as “liquid fuels and blending components produced from biomass feedstocks, used primarily for transportation.”36 Examples of these organic fuels...Clearly there are a lot of advantages to the electric vehicle, but significant disadvantages have consumers waiting for solutions. One of the draw-backs

  3. Comparing dependent robust correlations.

    Science.gov (United States)

    Wilcox, Rand R

    2016-11-01

    Let r1 and r2 be two dependent estimates of Pearson's correlation. There is a substantial literature on testing H0  : ρ1  = ρ2 , the hypothesis that the population correlation coefficients are equal. However, it is well known that Pearson's correlation is not robust. Even a single outlier can have a substantial impact on Pearson's correlation, resulting in a misleading understanding about the strength of the association among the bulk of the points. A way of mitigating this concern is to use a correlation coefficient that guards against outliers, many of which have been proposed. But apparently there are no results on how to compare dependent robust correlation coefficients when there is heteroscedasicity. Extant results suggest that a basic percentile bootstrap will perform reasonably well. This paper reports simulation results indicating the extent to which this is true when using Spearman's rho, a Winsorized correlation or a skipped correlation.

  4. Observer dependent geometries

    CERN Document Server

    Hohmann, Manuel

    2014-01-01

    From general relativity we have learned the principles of general covariance and local Lorentz invariance, which follow from the fact that we consider observables as tensors on a spacetime manifold whose geometry is modeled by a Lorentzian metric. Approaches to quantum gravity, however, hint towards a breaking of these symmetries and the possible existence of more general, non-tensorial geometric structures. Possible implications of these approaches are non-tensorial transformation laws between different observers and an observer-dependent notion of geometry. In this work we review two different frameworks for observer dependent geometries, which may provide hints towards a quantization of gravity and possible explanations for so far unexplained phenomena: Finsler spacetimes and Cartan geometry on observer space. We discuss their definitions, properties and applications to observers, field theories and gravity.

  5. Myofilament length dependent activation

    Energy Technology Data Exchange (ETDEWEB)

    de Tombe, Pieter P.; Mateja, Ryan D.; Tachampa, Kittipong; Mou, Younss Ait; Farman, Gerrie P.; Irving, Thomas C. (IIT); (Loyola)

    2010-05-25

    The Frank-Starling law of the heart describes the interrelationship between end-diastolic volume and cardiac ejection volume, a regulatory system that operates on a beat-to-beat basis. The main cellular mechanism that underlies this phenomenon is an increase in the responsiveness of cardiac myofilaments to activating Ca{sup 2+} ions at a longer sarcomere length, commonly referred to as myofilament length-dependent activation. This review focuses on what molecular mechanisms may underlie myofilament length dependency. Specifically, the roles of inter-filament spacing, thick and thin filament based regulation, as well as sarcomeric regulatory proteins are discussed. Although the 'Frank-Starling law of the heart' constitutes a fundamental cardiac property that has been appreciated for well over a century, it is still not known in muscle how the contractile apparatus transduces the information concerning sarcomere length to modulate ventricular pressure development.

  6. Cyber Network Mission Dependencies

    Science.gov (United States)

    2015-09-18

    Technology applications 12 5 VMs allow one host to belong to multiple VLANs 14 6 Asset recommendation system mockup 15 7 Perturbative mapping may...extended list of critical assets based on communications patterns and software dependencies. Once vulnerabilities have been assessed, AMMO produces a...status of not just network machines, but also software tools, network connections, server room conditions, and many other mission parameters. From this

  7. ARL Arabic Dependency Treebank

    Science.gov (United States)

    2016-02-10

    Detection for Modern Standard Arabic to English MT” (Tratz, 2014). The LDC is one of the foremost sources of annotated data used in computational... vowel diacritic—the typical indicator of genitive case—was not written, the DET label would appear on one line with the Al definite determiner, the... English dependency label scheme (de Marneffe & Manning, 2008). However, this is to not to say that they may always be interpreted identically. Also

  8. Dependence, Risk, and Vulnerability.

    Science.gov (United States)

    1981-06-01

    B2 has a great deal. The measurement strategy outlined here will gauge A’s import depen- dence on B2 as greater than A’s import dependence on B1 . One...pp 25 Doctrines: One More Time." 43 pp., Jan 1960. Glee. Devid V.; Hsoi. Ih-Chses: Nu,n, Welter A. AD AOIl 192 PP 283 mnd Penn, David A.. "A Clas of

  9. Complex Systems and Dependability

    CERN Document Server

    Zamojski, Wojciech; Sugier, Jaroslaw

    2012-01-01

    Typical contemporary complex system is a multifaceted amalgamation of technical, information, organization, software and human (users, administrators and management) resources. Complexity of such a system comes not only from its involved technical and organizational structure but mainly from complexity of information processes that must be implemented in the operational environment (data processing, monitoring, management, etc.). In such case traditional methods of reliability analysis focused mainly on technical level are usually insufficient in performance evaluation and more innovative meth

  10. Multiple Scattering: Dispersion, Temperature Dependence, and Annular Pistons

    CERN Document Server

    Milton, Kimball A; Parashar, Prachi; Cavero-Pelaez, Ines; Brevik, Iver; Ellingsen, Simen A

    2010-01-01

    We review various applications of the multiple scattering approach to the calculation of Casimir forces between separate bodies, including dispersion, wedge geometries, annular pistons, and temperature dependence. Exact results are obtained in many cases.

  11. Dependent rational providers.

    Science.gov (United States)

    Brothers, Kyle B

    2011-04-01

    Provider claims to conscientious objection have generated a great deal of heated debate in recent years. However, the conflicts that arise when providers make claims to the "conscience" are only a subset of the more fundamental challenges that arise in health care practice when patients and providers come into conflict. In this piece, the author provides an account of patient-provider conflict from within the moral tradition of St. Thomas Aquinas. He argues that the practice of health care providers should be understood as a form of practical reasoning and that this practical reasoning must necessarily incorporate both "moral" and "professional" commitments. In order to understand how the practical reasoning of provider should account for the needs and commitments of the patient and vice versa, he explores the account of dependence provided by Alasdair MacIntyre in his book Dependent Rational Animals. MacIntyre argues that St. Thomas' account of practical reasoning should be extended and adapted to account for the embodied vulnerability of all humans. In light of this insight, providers must view patients not only as the subjects of their moral reflection but also as fellow humans upon whom the provider depends for feedback on the effectiveness and relevance of her practical reasoning. The author argues that this account precludes responsive providers from adopting either moral or professional conclusions on the appropriateness of interventions outside the individual circumstances that arise in particular situations. The adoption of this orientation toward patients will neither eradicate provider-patient conflict nor compel providers to perform interventions to which they object. But this account does require that providers attend meaningfully to the suffering of patients and seek feedback on whether their intervention has effectively addressed that suffering.

  12. Case report

    African Journals Online (AJOL)

    abp

    Primary omental torsion in children: case report ... Primary omental torsion is a rare cause of acute abdominal pain, we report a case of 10-year-old boy admitted with ... Pan African Medical Journal. ... nausea, vomiting, and diarrhea may occur.

  13. Event dependent sampling of recurrent events

    DEFF Research Database (Denmark)

    Kvist, Tine Kajsa; Andersen, Per Kragh; Angst, Jules

    2010-01-01

    The effect of event-dependent sampling of processes consisting of recurrent events is investigated when analyzing whether the risk of recurrence increases with event count. We study the situation where processes are selected for study if an event occurs in a certain selection interval. Motivation...... retrospective and prospective disease course histories are used. We examine two methods to correct for the selection depending on which data are used in the analysis. In the first case, the conditional distribution of the process given the pre-selection history is determined. In the second case, an inverse......-probability-of-selection weighting scheme is suggested. The ability of the methods to correct for the bias due to selection is investigated with simulations. Furthermore, the methods are applied to affective disease data from a register-based study (Kessing et al. Br J Psychiatry 185:372-377, 2004a) and from a long-term clinical...

  14. Numerical solutions of Williamson fluid with pressure dependent viscosity

    Science.gov (United States)

    Zehra, Iffat; Yousaf, Malik Muhammad; Nadeem, Sohail

    In the present paper, we have examined the flow of Williamson fluid in an inclined channel with pressure dependent viscosity. The governing equations of motion for Williamson fluid model under the effects of pressure dependent viscosity and pressure dependent porosity are modeled and then solved numerically by the shooting method with Runge Kutta Fehlberg for two types of geometries i.e., (i) Poiseuille flow and (ii) Couette flow. Four different cases for pressure dependent viscosity and pressure dependent porosity are assumed and the physical features of pertinent parameters are discussed through graphs.

  15. Numerical solutions of Williamson fluid with pressure dependent viscosity

    Directory of Open Access Journals (Sweden)

    Iffat Zehra

    2015-01-01

    Full Text Available In the present paper, we have examined the flow of Williamson fluid in an inclined channel with pressure dependent viscosity. The governing equations of motion for Williamson fluid model under the effects of pressure dependent viscosity and pressure dependent porosity are modeled and then solved numerically by the shooting method with Runge Kutta Fehlberg for two types of geometries i.e., (i Poiseuille flow and (ii Couette flow. Four different cases for pressure dependent viscosity and pressure dependent porosity are assumed and the physical features of pertinent parameters are discussed through graphs.

  16. Velocity dependant splash behaviour

    Science.gov (United States)

    Hamlett, C. A. E.; Shirtcliffe, N. J.; McHale, G.; Ahn, S.; Doerr, S. H.; Bryant, R.; Newton, M. I.

    2012-04-01

    Extreme soil water repellency can occur in nature via condensation of volatile organic compounds released during wildfires and can lead to increased erosion rate. Such extreme water repellent soil can be classified as superhydrophobic and shares similar chemical and topographical features to specifically designed superhydrophobic surfaces. Previous studies using high speed videography to investigate single droplet impact behaviour on artificial superhydrophobic have revealed three distinct modes of splash behaviour (rebound, pinned and fragmentation) which are dependent on the impact velocity of the droplet. In our studies, using high-speed videography, we show that such splash behaviour can be replicated on fixed 'model' water repellent soils (hydrophobic glass beads/particles). We show that the type of splash behaviour is dependent on both the size and chemical nature of the fixed particles. The particle shape also influences the splash behaviour as shown by drop impact experiments on fixed sand samples. We have also studied soil samples, as collected from the field, which shows that the type of droplet splash behaviour can lead to enhanced soil particle transport.

  17. [Health Technology Dependency: A Concept Analysis].

    Science.gov (United States)

    Chen, Miao-Yi; Chen, Ting-Yu; Kao, Chi-Wen

    2016-02-01

    Health technology dependence is a widely recognized concept that refers to the utilization of technology, including drugs, equipment, instruments, and related devices, to compensate for a physical disability or to prevent the progression of a disability. Although technology may significantly prolong the life of a patient, technology may also increase the psychological pressure of these patients and the burdens of their caregivers. There is a current dearth of related research and discussions related to the concept of "health technology dependency". Therefore, the present paper uses the strategies of concept analysis described by Walker & Avant (2010) to analyze this concept. The characteristic definition of health technology dependence addresses individuals who: (1) currently live with health technology, (2) may perceive physical or psychological burdens due to health technology, and (3) feel physical and psychological well-being when coping positively with their health technology dependency and, further, regard health technology as a part of their body. Further, the present paper uses case examples to help analyze the general concept. It is hoped that nurses may better understand the concept of "health technology dependency", consider the concerns of health-technology-dependent patients and their families, and develop relevant interventions to promote the well-being of these patients and their families.

  18. Dependence of electromagnetically induced transparency on temperature

    Institute of Scientific and Technical Information of China (English)

    Xiao Feng; Guo Rui-Min; Li Lu-Ming; Yang Dong-Hai; Chen Xu-Zong

    2004-01-01

    @@ We performed an experimental study on the dependence of the linewidth of electromagetically induced transparency (EIT) on the temperature of medium in a A-type configuration using caesium vapour. We found that the transparent window is narrowed in the EIT whose two ground levels are composed of two hyperfine levels, and broadened in the case when the two ground levels are degenerated Zeeman sublevels, as the temperature of vapour cell is increased. The explanation for the phenomena is given qualitatively.

  19. Robust frame-dependent video watermarking

    Science.gov (United States)

    Holliman, Matthew J.; Macy, William W.; Yeung, Minerva M.

    2000-05-01

    In this paper, we describe some of the problems associated with watermarking key management, with particular attention to the case of video. We also describe a possible solution to the problem, which is that of image-dependent watermarking, and briefly discuss some of the possible advantages to be gained from adopting such an approach. The paper also presents a simple, efficient means of robustly extracting bits from a video sequence. The algorithm has applications to secure, oblivious video watermark detection.

  20. State dependent matrices and balanced energy functions for nonlinear systems

    NARCIS (Netherlands)

    Scherpen, Jacquelien M.A.; Gray, W. Steven

    2000-01-01

    The nonlinear extension of the balancing procedure requires the case of state dependent quadratic forms for the energy functions, i.e., the nonlinear extensions of the linear Gramians are state dependent matrices. These extensions have some interesting ambiguities that do not occur in the linear cas

  1. Efficient Dependence Analysis for UML Statechart Diagrams and Its Applications

    Institute of Scientific and Technical Information of China (English)

    YITong; WUFangjun

    2005-01-01

    Dependence analysis is a well-known technique to analyze, understand and maintain programs,which has been widely used in activities of software engineering and reengineering. Although dependence analysis for programs written in high-level languages has been widely studied in literatures, very little work is involved in analyzing dependence for Unified modeling language(UML) models. Therefore, the paper proposes a new approach for analyzing dependences among UML statechart diagrams for three cases: (1) it does not contain composite states; (2) it may include ordinal substates; (3) it may include concurrent substates. Firstly, we analyze and compute data and control dependences in Case 1 and Case 2 at full length. Then, using the information obtained in the previous steps, we discuss concurrent dependence and synchronal dependence besides data and control dependencesin Case 3. Finally, we present one of the most important applications of dependence analysis - program slicing, using the method presented in this paper. Our method successfully solves the problems in previous methods, and can obtain more precise slices than any other methods we known.

  2. Strong near-epoch dependence

    Institute of Scientific and Technical Information of China (English)

    LIN Zhengyan

    2004-01-01

    We introduce a new class of dependent sequences of random variables, which is a subclass of near-epoch dependent sequences, but can also be approximated by mixing sequences. For this kind of sequences of random variables, we call them strong nearepoch dependent sequences, a p-order, p > 2, (maximum) moment inequality is established under weaker dependence sizes.

  3. Percolation on networks with weak and heterogeneous dependency

    Science.gov (United States)

    Kong, Ling-Wei; Li, Ming; Liu, Run-Ran; Wang, Bing-Hong

    2017-03-01

    In real networks, the dependency between nodes is ubiquitous; however, the dependency is not always complete and homogeneous. In this paper, we propose a percolation model with weak and heterogeneous dependency; i.e., dependency strengths could be different between different nodes. We find that the heterogeneous dependency strength will make the system more robust, and for various distributions of dependency strengths both continuous and discontinuous percolation transitions can be found. For Erdős-Rényi networks, we prove that the crossing point of the continuous and discontinuous percolation transitions is dependent on the first five moments of the dependency strength distribution. This indicates that the discontinuous percolation transition on networks with dependency is determined not only by the dependency strength but also by its distribution. Furthermore, in the area of the continuous percolation transition, we also find that the critical point depends on the first and second moments of the dependency strength distribution. To validate the theoretical analysis, cases with two different dependency strengths and Gaussian distribution of dependency strengths are presented as examples.

  4. On Capital Dependent Dynamics of Knowledge

    CERN Document Server

    Szydlowski, M; Szydlowski, Marek; Krawiec, Adam

    2006-01-01

    We investigate the dynamics of growth models in terms of dynamical system theory. We analyse some forms of knowledge and its influence on economic growth. We assume that the rate of change of knowledge depends on both the rate of change of physical and human capital. First, we study model with constant savings. The model with optimised behaviour of households is also considered. We show that the model where the rate of change of knowledge depends only on the rate of change of physical capital can be reduced to the form of the two-dimensional autonomous dynamical system. All possible evolutional paths and the stability of solutions in the phase space are discussed in details. We obtain that the rate of growth of capital, consumption and output are greater in the case of capital dependent rate of change of knowledge.

  5. Seasonal Dependence in the Solar Neutrino Flux

    CERN Document Server

    De Holanda, P C; González-Garciá, M Concepción; Valle, José W F

    1999-01-01

    MSW solutions of the solar neutrino problem predict a seasonal dependence of the zenith angle distribution of the event rates, due to the non-zero latitude at the Super-Kamiokande site. We calculate this seasonal dependence and compare it with the expectations in the no-oscillation case as well as just-so scenario, in the light of the latest Super-Kamiokande 708-day data. The seasonal dependence can be sizeable in the large mixing angle MSW solution and would be correlated with the day-night effect. This may be used to discriminate between MSW and just-so scenarios and should be taken into account in refined fits of the data.

  6. Quintessential Scale Dependence from Separate Universe Simulations

    CERN Document Server

    Chiang, Chi-Ting; Hu, Wayne; LoVerde, Marilena

    2016-01-01

    By absorbing fluctuations into a local background, separate universe simulations provide a powerful technique to characterize the response of small-scale observables to the long-wavelength density fluctuations, for example those of the power spectrum and halo mass function which lead to the squeezed-limit $n$-point function and halo bias, respectively. Using quintessence dark energy as the paradigmatic example, we extend these simulation techniques to cases where non-gravitational forces in other sectors establish a Jeans scale across which the growth of density fluctuations becomes scale dependent. By characterizing the separate universes with matching background expansion histories, we show that the power spectrum and mass function responses depend on whether the long-wavelength mode is above or below the Jeans scale. Correspondingly, the squeezed bispectrum and halo bias also become scale dependent. Models of bias that are effectively local in the density field at a single epoch, initial or observed, canno...

  7. Loss aversion with a state-dependent reference point

    OpenAIRE

    Georgi, Enrico; Post, Thierry

    2010-01-01

    This study investigates loss aversion when the reference point is a state-dependent random variable. This case describes, for example, a money manager being evaluated relative to a risky benchmark index rather than a fixed target return level. Using a state-dependent structure, prospects are more (less) attractive if they depend positively (negatively) on the reference point. In addition, the structure avoids an inherent aversion to risky prospects and yields no losses when the prospect and t...

  8. [Frequency dependance of compliance].

    Science.gov (United States)

    Gayrard, P

    1975-01-01

    Resistance of peripheral or "small" airways is only a small part of the total pulmonary resistance (Raw). Even considerable obstruction in these airways will have little effect on total resistance. Conversely this will lead to inequality in the time constants of units in parallel, and dynamic lung compliance (C dyn) shall fall as respiratory frequence increases. C dyn is measured from simultaneous recordings of transpulmonary pressure (esophageal balloon) and volume obtained from a volume displacement plethysmograph. If Raw and static compliance are found to be normal, the frequency dependance of compliance will result from peripheral airway obstruction only. Early stages of chronic airway obstruction can be established by this method. However this appear not suitable for wide-scale studies.

  9. Helicity dependent parton distributions

    CERN Document Server

    Scopetta, Sergio; 10.4249/scholarpedia.10226

    2011-01-01

    The helicity dependent parton distributions describe the number density of partons with given longitudinal momentum x and given polarization in a hadron polarized longitudinally with respect to its motion. After the discovery, more than 70 years ago, that the proton is not elementary, the observation of Bjorken scaling in the late 1960s lead to the idea of hadrons containing almost pointlike constituents, the partons. Since then, Deep Inelastic Scattering (DIS) has played a crucial role in our understanding of hadron structure. Through DIS experiments it has been possible to link the partons to the quarks, and to unveil the presence of other pointlike constituents, the gluons, which lead into a dynamical theory of quarks and gluons - quantum chromodynamics (QCD). Polarized DIS, i.e. the collision of a longitudinally polarized lepton beam on a polarized target (either longitudinally or transversely polarized), provides a complementary information regarding the structure of the nucleon. Whereas ordinary DIS pro...

  10. Chemical Dependence and Personality

    Directory of Open Access Journals (Sweden)

    Carlos Henrique Sancineto da Silva Nunes

    2009-01-01

    Full Text Available This study investigated the relationships between chemical dependency and personalitystructure in a Brazilian sample. Participants were college students (n=35 and patients of a drug recovery center (n= 48. Two personality scales based on the Big-5 Model were used to measure Extraversion and Agreeableness. A semi-structured interview was used to identify events in the patients' life histories that might support specific classifications. Participants' scores were also compared to Brazilian normative samples. The results showed significant differences between clinical and non-clinical groups in Agreeableness, but not in Extraversion. Logistic regression analyses were conducted using scales and interview aspects for predicting group membership. The model showed 92.1% general predictive power. Results pointed to the advantage of using both interview and objective techniques to assess individuals with antisocial personality symptoms.

  11. Time-dependent exact solutions of the nonlinear Kompaneets equation

    Energy Technology Data Exchange (ETDEWEB)

    Ibragimov, N H, E-mail: nib@bth.s [Department of Mathematics and Science, Blekinge Institute of Technology, 371 79 Karlskrona (Sweden)

    2010-12-17

    Time-dependent exact solutions of the Kompaneets photon diffusion equation are obtained for several approximations of this equation. One of the approximations describes the case when the induced scattering is dominant. In this case, the Kompaneets equation has an additional symmetry which is used for constructing some exact solutions as group invariant solutions. (fast track communication)

  12. Anticonvulsants for alcohol dependence.

    Science.gov (United States)

    Pani, Pier Paolo; Trogu, Emanuela; Pacini, Matteo; Maremmani, Icro

    2014-02-13

    Alcohol dependence is a major public health problem that is characterised by recidivism and a host of medical and psychosocial complications. Besides psychosocial interventions, different pharmacological interventions have been or currently are under investigation through Cochrane systematic reviews. The primary aim of the review is to assess the benefits/risks of anticonvulsants for the treatment of alcohol dependence. We searched the Cochrane Drugs and Alcohol Group Trials Register (October 2013), PubMed (1966 to October 2013), EMBASE (1974 to October 2013) and CINAHL (1982 to October 2013). Randomised controlled trials (RCTs) and controlled clinical trials (CCTs) comparing anticonvulsants alone or in association with other drugs and/or psychosocial interventions versus placebo, no treatment and other pharmacological or psychosocial interventions. We used standard methodological procedures as expected by The Cochrane Collaboration. A total of 25 studies were included in the review (2641 participants). Most participants were male, with an average age of 44 years. Anticonvulsants were compared with placebo (17 studies), other medications (seven studies) and no medication (two studies). The mean duration of the trials was 17 weeks (range four to 52 weeks). The studies took place in the USA, Europe, South America, India and Thailand. Variation was reported in the characteristics of the studies, including their design and the rating instruments used. For many key outcomes, the risk of bias associated with unclear or unconcealed allocation and lack of blinding affected the quality of the evidence.Anticonvulsants versus placebo: For dropouts (16 studies, 1675 participants, risk ratio (RR) 0.94, 95% confidence interval (Cl) 0.74 to 1.19, moderate-quality evidence) and continuous abstinence (eight studies, 634 participants, RR 1.21, 95% Cl 95% 0.97 to 1.52, moderate-quality evidence), results showed no evidence of differences. Moderate-quality evidence suggested that

  13. Acamprosate for alcohol dependence

    Directory of Open Access Journals (Sweden)

    Susanne Rösner

    Full Text Available BACKGROUND: Alcohol dependence is among the main leading health risk factors in most developed and developing countries. Therapeutic success of psychosocial programs for relapse prevention is moderate, but could potentially be increased by an adjuvant treatment with the glutamate antagonist acamprosate. OBJECTIVE: To determine the effectiveness and tolerability of acamprosate in comparison to placebo and other pharmacological agents. CRITERIA FOR CONSIDERING STUDIES FOR THIS REVIEW: We searched the Cochrane Drugs and Alcohol Group (CDAG Specialized Register, PubMed, Embase and CINAHL in January 2009 and inquired manufacturers and researchers for unpublished trials. SELECTION CRITERIA: All double-blind randomised controlled trials (RCTs which compare the effects of acamprosate with placebo or active control on drinking-related outcomes. DATA COLLECTION AND ANALYSIS: Two authors independently extracted data. Trial quality was assessed by one author and cross-checked by a second author. Individual patient data (IPD meta-analyses were used to verify the primary effectiveness outcomes. MAIN RESULTS: 24 RCTs with 6915 participants fulfilled the criteria of inclusion and were included in the review. Compared to placebo, acamprosate was shown to significantly reduce the risk of any drinking RR 0.86 (95% CI 0.81 to 0.91; NNT 9.09 (95% CI 6.66 to 14.28 and to significantly increase the cumulative abstinence duration MD 10.94 (95% CI 5.08 to 16.81, while secondary outcomes (gamma-glutamyltransferase, heavy drinking did not reach statistical significance. Diarrhea was the only side effect that was more frequently reported under acamprosate than placebo RD 0.11 (95% 0.09 to 0.13; NNTB 9.09 (95% CI 7.69 to 11.11. Effects of industry-sponsored trials RR 0.88 (95% 0.80 to 0.97 did not significantly differ from those of non-profit funded trials RR 0.88 (95% CI 0.81 to 0.96. In addition, the linear regression test did not indicate a significant risk of

  14. [Obstructive anuria. Thirty cases].

    Science.gov (United States)

    Bennani, S; Debbagh, A; Joual, A; el Mrini, M; Benjelloun, S

    1995-01-01

    The authors report 30 cases of obstructive anuria during the last fifteen years. The anuria was secondary to lithiasis in 60 per cent, in 26.6 per cent to pelvic cancer and in 13.4 per cent to retroperitoneal fibrosis. The diagnosis was facilitated by ultrasonography. Emergency treatment of obstructive anuria is based on urinary diversion by ureteral stent or by percutaneous nephrostomy under ultrasound control. Later the treatment depend of etiology.

  15. Assurance Cases

    Science.gov (United States)

    2015-01-26

    2015 Carnegie Mellon University Assurance Cases Software Engineering Institute Carnegie Mellon University Pittsburgh, PA 15213 Charles B...1. REPORT DATE 26 JAN 2015 2. REPORT TYPE N/A 3. DATES COVERED 4. TITLE AND SUBTITLE Assurance Cases 5a. CONTRACT NUMBER 5b. GRANT NUMBER... Assurance Cases Charles B. Weinstock, January 2015 © 2015 Carnegie Mellon University Copyright 2015 Carnegie Mellon University This material is based upon

  16. Density dependent neurodynamics.

    Science.gov (United States)

    Halnes, Geir; Liljenström, Hans; Arhem, Peter

    2007-01-01

    The dynamics of a neural network depends on density parameters at (at least) two different levels: the subcellular density of ion channels in single neurons, and the density of cells and synapses at a network level. For the Frankenhaeuser-Huxley (FH) neural model, the density of sodium (Na) and potassium (K) channels determines the behaviour of a single neuron when exposed to an external stimulus. The features of the onset of single neuron oscillations vary qualitatively among different regions in the channel density plane. At a network level, the density of neurons is reflected in the global connectivity. We study the relation between the two density levels in a network of oscillatory FH neurons, by qualitatively distinguishing between three regions, where the mean network activity is (1) spiking, (2) oscillating with enveloped frequencies, and (3) bursting, respectively. We demonstrate that the global activity can be shifted between regions by changing either the density of ion channels at the subcellular level, or the connectivity at the network level, suggesting that different underlying mechanisms can explain similar global phenomena. Finally, we model a possible effect of anaesthesia by blocking specific inhibitory ion channels.

  17. Sensory processing disorders among substance dependents

    Directory of Open Access Journals (Sweden)

    Batya Engel-Yeger

    2014-08-01

    Full Text Available Purpose: (1 To compare sensory processing patterns as expressed in daily life between substance dependents and typical controls; (2 profile the prevalence of sensory processing disorders (SPD among substance dependents; and (3 examine gender effect on SPD within and between groups. Methods: Two hundred ninety people aged 19-64 participated in this study. The study group included 145 individuals who lived in the community or took part in an outpatient program because of addiction to drugs/alcohol and had been clean for over three months. The control group included 145 individuals who were not exposed to drugs or alcohol on a regular basis and did not suffer from addictive behavior. All participants filled a demographic questionnaire. Those who met the inclusion criteria completed the Adolescent/Adult Sensory Profile (AASP so that their sensory processing patterns could be assessed. Results: When comparing both groups, the study group showed greater sensory sensitivity and significantly higher prevalence of SPD. Significant group/gender interaction was found in regard to sensation seeking. Discussion: SPD among substance dependents may be expressed in daily life by either hypersensitivity or hyposensitivity. The behavioral outcomes reflected by the AASP support neurophysiological manifestations about SPD of substance dependents. The evaluation process of substance dependents should refer to their sensory processing abilities. In case SPD is diagnosed, Occupational Therapy and specific sensory–based interventions should be considered in order to fit the specific needs of individuals and enhance their performance, meaningful participation, and quality of life.

  18. Context-dependent generalization.

    Science.gov (United States)

    Taylor, Jordan A; Ivry, Richard B

    2013-01-01

    The pattern of generalization following motor learning can provide a probe on the neural mechanisms underlying learning. For example, the breadth of generalization to untrained regions of space after visuomotor adaptation to targets in a restricted region of space has been attributed to the directional tuning properties of neurons in the motor system. Building on this idea, the effect of different types of perturbations on generalization (e.g., rotation vs. visual translation) have been attributed to the selection of differentially tuned populations. Overlooked in this discussion is consideration of how the context of the training environment may constrain generalization. Here, we explore the role of context by having participants learn a visuomotor rotation or a translational shift in two different contexts, one in which the array of targets were presented in a circular arrangement and the other in which they were presented in a rectilinear arrangement. The perturbation and environments were either consistent (e.g., rotation with circular arrangement) or inconsistent (e.g., rotation with rectilinear arrangement). The pattern of generalization across the workspace was much more dependent on the context of the environment than on the perturbation, with broad generalization for the rectilinear arrangement for both types of perturbations. Moreover, the generalization pattern for this context was evident, even when the perturbation was introduced in a gradual manner, precluding the use of an explicit strategy. We describe how current models of generalization might be modified to incorporate these results, building on the idea that context provides a strong bias for how the motor system infers the nature of the visuomotor perturbation and, in turn, how this information influences the pattern of generalization.

  19. Context-dependent Generalization

    Directory of Open Access Journals (Sweden)

    Jordan A Taylor

    2013-05-01

    Full Text Available The pattern of generalization following motor learning can provide a probe on the neural mechanisms underlying learning. For example, the breadth of generalization to untrained regions of space after visuomotor adaptation to targets in a restricted region of space has been attributed to the directional tuning properties of neurons in the motor system. Building on this idea, the effect of different types of perturbations on generalization (e.g., rotation versus visual translation have been attributed to the selection of differentially tuned populations. Overlooked in this discussion is consideration of how the context of the training environment may constrain generalization. Here, we explore the role of context by having participants learn a visuomotor rotation or a translational shift in two different contexts, one in which the array of targets were presented in a circular arrangement and the other in which they were presented in a rectilinear arrangement. The perturbation and environments were either consistent (e.g., rotation with circular arrangement or inconsistent (e.g., rotation with rectilinear arrangement. The pattern of generalization across the workspace was much more dependent on the context of the environment than on the perturbation, with broad generalization for the rectilinear arrangement for both types of perturbations. Moreover, the generalization pattern for this context was evident, even when the perturbation was introduced in a gradual manner, precluding the use of an explicit strategy. We describe how current models of generalization might be modified to incorporate these results, building on the idea that context provides a strong bias for how the motor system infers the nature of the visuomotor perturbation and, in turn, how this information influences the pattern of generalization.

  20. Texting Dependence, iPod Dependence, and Delay Discounting.

    Science.gov (United States)

    Ferraro, F Richard; Weatherly, Jeffrey N

    2016-01-01

    We gave 127 undergraduates questionnaires about their iPod and texting dependence and 2 hypothetical delay discounting scenarios related to free downloaded songs and free texting for life. Using regression analyses we found that when iPod dependence was the dependent variable, Text2-excessive use, Text4-psychological and behavioral symptoms, iPod2-excessive use, and iPod3-relationship disruption were significant predictors of discounting. When texting dependence was the dependent variable, Text4-psychological and behavioral symptoms and iPod3-relationship disruption were significant predictors of discounting. These are the first data to show that delay discounting relates to certain aspects of social media, namely iPod and texting dependence. These data also show that across these 2 dependencies, both psychological and behavioral symptoms and relationship disruptions are affected.

  1. Functional Dependencies and Its Axiom System in XML

    Institute of Scientific and Technical Information of China (English)

    ZHAO Xiangguo; WANG Guoren; HOU Huan; DING Dabin

    2007-01-01

    According to the analysis of existing complicated functional dependencies constraint, we conclude the conditions of defining functional dependency in XML, and then we introduce the concept of the node value equality. Anew path language and a new definition of functional dependencies in XML (XFD) are proposed.XFD includes the relative XFD and the absolute XFD, in which absolute key and relative key are the particular cases. We focus on the logical implication and the closure problems, and propose a group of inference rules. Finally, some proofs of the correctness and completeness are given. XFD is powerful on expressing functional dependencies in XML causing data redundancy, and has a complete axiom system.

  2. Gaussian Fluctuations for Sample Covariance Matrices with Dependent Data

    CERN Document Server

    Friesen, Olga; Stolz, Michael

    2012-01-01

    It is known (Hofmann-Credner and Stolz (2008)) that the convergence of the mean empirical spectral distribution of a sample covariance matrix W_n = 1/n Y_n Y_n^t to the Mar\\v{c}enko-Pastur law remains unaffected if the rows and columns of Y_n exhibit some dependence, where only the growth of the number of dependent entries, but not the joint distribution of dependent entries needs to be controlled. In this paper we show that the well-known CLT for traces of powers of W_n also extends to the dependent case.

  3. Satisfiability with Index Dependency

    Institute of Scientific and Technical Information of China (English)

    Hong-Yu Liang; Jing He

    2012-01-01

    We study the Boolean satisfiability problem (SAT) restricted on input formulas for which there are linear arithmetic constraints imposed on the indices of variables occurring in the same clause.This can be seen as a structural counterpart of Schaefer's dichotomy theorem which studies the SAT problem with additional constraints on the assigned values of variables in the same clause.More precisely,let k-SAT(m,A) denote the SAT problem restricted on instances of k-CNF formulas,in every clause of which the indices of the last k-m variables are totally decided by the first m ones through some linear equations chosen from A.For example,if A contains i3 =i1+2i2 and i4 =i2-i1 + 1,then a clause of the input to 4-SAT(2,A) has the form yi1∨yi2∨yi1+2i2∨yi2-i1+1,with yi being xi or (xi).We obtain the following results:1) If m ≥2,then for any set A of linear constraints,the restricted problem k-SAT(m,A) is either in P or NP-complete assuming P ≠ NP.Moreover,the corresponding #SAT problem is always #P-complete,and the MAx-SAT problem does not allow a polynomial time approximation scheme assuming P ≠ NP.2) m =1,that is,in every clause only one index can be chosen freely.In this case,we develop a general framework together with some techniques for designing polynomial-time algorithms for the restricted SAT problems.Using these,we prove that for any A,#2-SAT(1,A) and MAX-2-SAT(1,A) are both polynomial-time solvable,which is in sharp contrast with the hardness results of general #2-SAT and MAX-2-SAT.For fixed k≥ 3,we obtain a large class of non-trivial constraints A,under which the problems k-SAT(1,A),#k-SAT(1,A)and MAx-k-SAT(1,A) can all be solved in polynomial time or quasi-polynomial time.

  4. Gabapentin-induced delirium and dependence.

    Science.gov (United States)

    Kruszewski, Stefan P; Paczynski, Richard P; Kahn, David A

    2009-07-01

    Gabapentin (Neurontin) is approved by the US Food and Drug Administration for treatment of epilepsy and post-herpetic neuralgia. Despite lack of strong evidence, gabapentin is also often prescribed off-label for psychiatric conditions. The case described here involved a 38-year-old male physician with substance intoxication delirium and psychoactive substance dependence due to high self-administered doses of gabapentin, which had been prescribed at lower doses in combination with buspirone and bupropion for depression and anxiety. This unusual case of gabapentin dependence and abuse involved toxic delirium, intense cravings, and a prolonged post-withdrawal confusional state reminiscent of benzodiazepine withdrawal. Gabapentin is a central nervous system inhibitory agent with likely gamma-aminobutyric acid (GABA)-ergic and non-GABAergic mechanisms of action. The similarity between benzodiazepine withdrawal and what this patient experienced with gabapentin suggests a common role for GABA-related effects. The case reported here suggests the need for heightened concern regarding the off-label prescription of this drug to vulnerable individuals with psychiatric conditions.

  5. Case - Case-Law - Law

    DEFF Research Database (Denmark)

    Sadl, Urska

    2013-01-01

    Reasoning of the Court of Justice of the European Union – Constr uction of arguments in the case-law of the Court – Citation technique – The use of formulas to transform case-law into ‘law’ – ‘Formulaic style’ – European citizenship as a fundamental status – Ruiz Zambrano – Reasoning from...

  6. Drug Craving Terminology among Opiate Dependents

    Directory of Open Access Journals (Sweden)

    Masoomeh Maarefvand

    2013-06-01

    Full Text Available Objective:Drug craving is defined as an urge to continue substance abuse. Drug dependents use different terms to express their subjective feeling of craving. This study was an attempt to generate an understanding of craving terminology among different groups of Persian speaking Iranian opiate dependents.Method:Terms used for the meaning of drug craving were listed by 36 ex-opiate dependents in focus group discussion meetings in the first phase of the study. These terms were composed from Craving Terms Questionnaire. In the second phase, 120 subjects in 3 groups of opiate dependents and a group of Current Opiate Abusers rated usage frequency of each term in the questionnaire under a Twelve-Step Program, Methadone Maintenance, and Other Abstinence-based Programs.Results:Eighty nine terms were categorized in stimulation and triggering, attention bias and obsession, decision making difficulty, information processing impairment, withdrawal induction, drug euphoric experience, mental urge, motor control problem, negative valancing and stigmatizing. Terms for the three categories of mental urge, attention bias and obsession and motor control problem were used more than others. Patients in Methadone Maintenance Treatment (MMT group used different categories of craving terms in comparison to other groups. Abstinent cases reported higher total score for craving terms in comparison to other groups in Twelve-Step Program and other abstinence-based programs.Conclusion:Each craving-related term is associated with some aspects of the multidimensional concept of craving. A drug-craving thesaurus could provide a better understanding of craving nature from a drug dependent point of view. There are differences among abstinence vs. maintenance based treated opiate dependents in using craving terms. Addiction therapists will benefit from accessing drug dependents’ lexicon to assess and create therapeutic alliance with their clients.

  7. CASE REPORT

    African Journals Online (AJOL)

    DR ABDUL

    reported a case of Ogilvie's syndrome following a caesarean delivery ... perinatal mortality has been attributed to the difficulty in the early diagnosis ... The abdomen was full, moved with respiration and soft. There .... Acute intestinal obstruction.

  8. Case report

    African Journals Online (AJOL)

    abp

    Cerebral venous sinus thrombosis in HIV-infected patients: report of 2 cases. Julius Chacha ... affected adults are women, and direct causes or predisposing risk factors can be .... Some studies have reported a high prevalence of antibodies.

  9. Case report

    African Journals Online (AJOL)

    abp

    2017-05-05

    May 5, 2017 ... Chondroblastic osteosarcoma of the distal tibia: a rare case report ... 1Department of Orthopaedic Surgery, University Hospital, Monastir, Tunisia .... number of published reports describe pulmonary tumour metastasis.

  10. Case report

    African Journals Online (AJOL)

    abp

    2014-03-28

    Mar 28, 2014 ... Iatrogenic cushing's syndrome in children following nasal steroid. Isaac Oludare .... which a diagnosis of adenoidal hypertrophy was made and he was ... Oyenusi participated in patients' management and review of case.

  11. Case report

    African Journals Online (AJOL)

    ebutamanya

    2016-03-24

    Mar 24, 2016 ... Meknes, Morocco, 3Department of Radiology, Military Hospital Moulay Ismail, Meknes, ... Our case raises the awareness among health professionals about ... abdomen was sensitive and on the digital rectal examination the.

  12. Case series

    African Journals Online (AJOL)

    abp

    2015-11-23

    Nov 23, 2015 ... The prevalence and characteristics of right heart endocarditis in Africa are not well ... Anaemia was present in 9 patients whilst leukocytosis in 6 patients. The .... three cases of renal impairment, heart failure in two patients and.

  13. Case report

    African Journals Online (AJOL)

    abp

    2017-06-29

    Jun 29, 2017 ... Von Willebrand's disease: case report and review of literature. Hanae Echahdi1 ... glycoprotein crucial for platelet adhesion to the subendothelium after vascular injury. VWD include .... minor surgery including dental work.

  14. Case note

    African Journals Online (AJOL)

    with the Criminal Procedure Act has caused interpretational difficulties. Two cases have provided ... based on reports by monitors and social workers who had found ..... legislation, where possible, in conformity with the. Constitution.32 Courts ...

  15. Case report

    African Journals Online (AJOL)

    abp

    2017-06-13

    Jun 13, 2017 ... Enterobiasis (oxyuriasis) is a common infection in human caused by Enterobius vermicularis (E. ... We report a case of oxyuriasis that took place in the refugee camp ... slightly painful, especially in the lower right quadrant.

  16. Case report

    African Journals Online (AJOL)

    ebutamanya

    2016-04-06

    Apr 6, 2016 ... A case of Kartagener syndrome with rhinolalia clausa. Mohammed ... ciliary movement; it was described by manes kartagener in 1933 comprising a triad of ... The speech therapy examination report revealed the presence ...

  17. Case report

    African Journals Online (AJOL)

    abp

    2017-07-14

    Jul 14, 2017 ... In this report, we present a case of osteogenesis imperfecta (OI) type IV, seen in a female fetus with ... without fractures, short stature, dentinogenesis imperfecta and ... curvature of the femurs were detected (Figure 2A).

  18. Case series

    African Journals Online (AJOL)

    abp

    2013-06-20

    Jun 20, 2013 ... Upper cervical spine injuries: a management of a series of 70 cases. El Fatemi ... women, with traffic accidents being the major traumatic cause. .... osteosynthesis is preferred to respect the biomechanics of the cervical spine ...

  19. Case Report

    African Journals Online (AJOL)

    Arab Journal of Nephrology and Transplantation. 2013 Sep;6(3):177-9 ... Further systemic clinical examination ... Sternal marrow aspiration revealed slight myelodysplasia consistent ... case, renal biopsy findings and clinical follow-up made.

  20. Open systems dependability dependability engineering for ever-changing systems

    CERN Document Server

    Tokoro, Mario

    2015-01-01

    The book describes a fundamentally new approach to software dependability, considering a software system as an ever-changing system due to changes in service objectives, users' requirements, standards and regulations, and to advances in technology. Such a system is viewed as an Open System since its functions, structures, and boundaries are constantly changing. Thus, the approach to dependability is called Open Systems Dependability. The DEOS technology realizes Open Systems Dependability. It puts more emphasis on stakeholders' agreement and accountability achievement for business/service cont

  1. Frequency Dependent Negative Resistance-A review

    Directory of Open Access Journals (Sweden)

    D.Susan

    2012-08-01

    Full Text Available Inductors are bulky and costly but reducing the size of the inductors reduces the quality factor. There is also a fundamental limitation of using inductor that it cannot be suitable for the micro miniature structure and integrated circuits applications. Because of these limitations, inductors cannot be used in most of the analog circuit applications. Hence simulated inductors are used as an alternative. In case the simulated inductor becomes floating some linear transformation is used which results in the formation of a new D element called the Frequency Dependent Negative Resistance (FDNR. This paper presents an overview of the basic circuits of simulating the Frequency Dependent Negative Resistance and its various applications in analog circuits in the place of floating inductor.

  2. Generalized Parametrization Dependence in Quantum Gravity

    CERN Document Server

    Gies, Holger; Lippoldt, Stefan

    2015-01-01

    We critically examine the gauge, and field-parametrization dependence of renormalization group flows in the vicinity of non-Gau\\ss{}ian fixed points in quantum gravity. While physical observables are independent of such calculational specifications, the construction of quantum gravity field theories typically relies on off-shell quantities such as $\\beta$ functions and generating functionals and thus face potential stability issues with regard to such generalized parametrizations. We analyze a two-parameter class of covariant gauge conditions, the role of momentum-dependent field rescalings and a class of field parametrizations. Using the product of Newton and cosmological constant as an indicator, the principle of minimum sensitivity identifies stationary points in this parametrization space which show a remarkable insensitivity to the parametrization. In the most insensitive cases, the quantized gravity system exhibits a non-Gau\\ss{}ian UV stable fixed point, lending further support to asymptotically free q...

  3. Quantification of Seepage in Groundwater Dependent Wetlands

    DEFF Research Database (Denmark)

    Johansen, Ole; Beven, Keith; Jensen, Jacob Birk

    2017-01-01

    Restoration and management of groundwater dependent wetlands require tools for quantifying the groundwater seepage process. A method for determining point estimates of the groundwater seepage based on water level observations is tested. The study is based on field data from a Danish rich fen...... to investigate the uncertainties of parameters and model results. Two different model structures are presented. One is using the physically based model code HYDRUS nek et al. 2009) which solves the 1D unsaturated flow problem. In this case five parameters from the Van Genuchten retention model are examined...... has been predicted. Both models suffer from the fundamental problem that no reliable observations for the predicted variable (seepage rate) exist. Thus the trust in the model therefore depends on the ability to reproduce water level observations. Assuming that the results can be fully validated...

  4. Asymptotic theory of weakly dependent random processes

    CERN Document Server

    Rio, Emmanuel

    2017-01-01

    Presenting tools to aid understanding of asymptotic theory and weakly dependent processes, this book is devoted to inequalities and limit theorems for sequences of random variables that are strongly mixing in the sense of Rosenblatt, or absolutely regular. The first chapter introduces covariance inequalities under strong mixing or absolute regularity. These covariance inequalities are applied in Chapters 2, 3 and 4 to moment inequalities, rates of convergence in the strong law, and central limit theorems. Chapter 5 concerns coupling. In Chapter 6 new deviation inequalities and new moment inequalities for partial sums via the coupling lemmas of Chapter 5 are derived and applied to the bounded law of the iterated logarithm. Chapters 7 and 8 deal with the theory of empirical processes under weak dependence. Lastly, Chapter 9 describes links between ergodicity, return times and rates of mixing in the case of irreducible Markov chains. Each chapter ends with a set of exercises. The book is an updated and extended ...

  5. Energy-dependent variability from accretion flows

    CERN Document Server

    Zdziarski, A A

    2005-01-01

    We develop a formalism to calculate energy-dependent fractional variability (rms) in accretion flows. We consider rms spectra resulting from radial dependencies of the level of local variability (as expected from propagation of disturbances in accretion flows) assuming the constant shape of the spectrum emitted at a given radius. We consider the cases when the variability of the flow is either coherent or incoherent between different radial zones. As example local emission, we consider blackbody, Wien and thermal Comptonization spectra. In addition to numerical results, we present a number of analytical formulae for the resulting rms. We also find an analytical formula for the disc Wien spectrum, which we find to be a very good approximation to the disc blackbody. We compare our results to the rms spectrum observed in an ultrasoft state of GRS 1915+105.

  6. Pulse Phase Dependence of the Magnetar Bursts

    Indian Academy of Sciences (India)

    Chetana Jain; Anjan Dutta; Biswajit Paul

    2007-12-01

    We report here results from a study of X-ray bursts from 3 magnetar candidates (SGR 1806–20, SGR 1900+14 and AXP 1E 2259+586). We have searched for a pulse phase dependence of the X-ray burst rate from these sources. X-ray light curves were obtained with the Proportional Counter Array on-board the Rossi X-ray Timing Explorer during the periods of intense burst activity in these sources. On detailed analysis of the three sources, we found a very significant burst rate for all pulsar phases. However, some locations appear to produce bursts slightly more often, rendering the non-isotropic distribution. Only in the case of SGR 1900+14, there is a clear pulse phase dependence of burst rate.

  7. Correlates of baclofen effectiveness in alcohol dependence

    Directory of Open Access Journals (Sweden)

    Lekhansh Shukla

    2015-01-01

    Full Text Available Alcohol dependence is a global concern. Baclofen has shown promise as an anti-craving agent but its efficiency remains to be settled. We reviewed 549 male cases diagnosed with alcohol dependence who received Acamprosate (201 or Baclofen (348. ′Time to first drink′ was compared between two groups and multiple regression analysis was done in baclofen group to identify correlates of effectiveness. There was a significant difference in outcome measure between Baclofen (M = 4.44, SD = 3.75 and Acamprosate group (M = 3.73, SD = 2.19; t (547 = 2.45, P = 0.01. Initial regression analysis with six predictor variables (average daily alcohol units, current age, age at onset of dependence, family history, duration of dependence and dose of baclofen in mg/day showed significant correlation of outcome variable with only two predictor variables - dose of baclofen and average daily intake. Using the hierarchical method it was found that ′dose of baclofen′ and ′average alcohol intake′ explain a significant amount of variance in ′time to first drink′. [F (1, 345 = 182.8, P < 0.001, R2 = 0.52, R2 adjusted = 0.51]. This information can be used to select patients in long term longitudinal studies and may explain variable results seen in clinical trials of baclofen done earlier.

  8. Cost of Oil Dependence: A 2000 Update

    Energy Technology Data Exchange (ETDEWEB)

    Greene, D.L.; Tishchishyna, N.I.

    2000-05-01

    Oil dependence remains a potentially serious economic and strategic problem for the United States. This report updates previous estimates of the costs of oil dependence to the U.S. economy and introduces several methodological enhancements. Estimates of the costs to the U.S. economy of the oil market upheavals of the last 30 years are in the vicinity of $7 trillion, present value 1998 dollars, about as large as the sum total of payments on the national debt over the same period. Simply adding up historical costs in 1998 dollars without converting to present value results in a Base Case cost estimate of $3.4 trillion. Sensitivity analysis indicates that cost estimates are sensitive to key parameters. A lower bound estimate of $1.7 trillion and an upper bound of $7.1 trillion (not present value) indicate that the costs of oil dependence have been large under almost any plausible set of assumptions. These cost estimates do not include military, strategic or political costs associated with U.S. and world dependence on oil imports.

  9. Costs of Oil Dependence: A 2000 Update

    Energy Technology Data Exchange (ETDEWEB)

    Greene, D.L.

    2000-05-17

    Oil dependence remains a potentially serious economic and strategic problem for the United States. This report updates previous estimates of the costs of oil dependence to the U.S. economy and introduces several methodological enhancements. Estimates of the costs to the U.S. economy of the oil market upheavals of the last 30 years are in the vicinity of $7 trillion, present value 1998 dollars, about as large as the sum total of payments on the national debt over the same period. Simply adding up historical costs in 1998 dollars without converting to present value results in a Base Case cost estimate of $3.4 trillion. Sensitivity analysis indicates that cost estimates are sensitive to key parameters. A lower bound estimate of $1.7 trillion and an upper bound of $7.1 trillion (not present value) indicate that the costs of oil dependence have been large under almost any plausible set of assumptions. These cost estimates do not include military, strategic or political costs associated with U.S. and world dependence on oil imports.

  10. Case Report

    DEFF Research Database (Denmark)

    Søborg, Marie-Louise Kulas; Rosenberg, Jacob; Burcharth, Jakob

    2016-01-01

    neuropathy (AMSAN). Reports of AMSAN with onset after epidural anesthesia and spinal surgery are extremely rare, and the linkage between development of GBS and neuroaxial anesthesia remains conclusively unconfirmed. We present a case in which the patient developed subacute motor and predominantly sensory...... neuropathy following epidural blockade. The case emphasizes the need of including AMSAN in differential diagnostic considerations to changes in motor and sensory function following epidural anesthesia, allowing accelerated rehabilitation and relevant alleviating therapy....

  11. Application of amikacin in a case of multi-anticoagulants dependent pseudothrombocytopenia%阿米卡星在1例多抗凝剂依赖性假性血小板减少症中的应用研究

    Institute of Scientific and Technical Information of China (English)

    张悦民; 王剑飚; 陈骊婷

    2015-01-01

    Objective: To investigate the mechanism of amikacin inhibiting platelet agglutination in a case of multi-anticoagulants dependent pseudothrombocytopenia (PTCA). Methods: EDTA-K2 and citrate anticoagulated blood samples were collected from an EDTA dependent PTCA patient. Amikacin was added into blood samples at different time points. Hematology analyzer was used to count platelets, blood smear to observe platelet agglutination, and flow cytometry to de-tect expression of platelet membrane markers, including CD61, CD42b, PAC-1, CD62p. Results: If amikacin was added into the EDTA-K2 anticoagulated blood within one hour after the collection it could inhibit the agglutination of platelet, dissociate the agglutinated platelet without affecting the morphology and distribution of other blood cells, and activation of platelet membrane surface markers CD62p was inhibited ,while the platelet count keep stable for four hours at room tem-perature. With the extension of time, the platelet count decreased obviously in citrated anticoagulated blood. Conclusions:The patient has multi-anticoagulants dependent pseudothrombocytopenia. Addition of amikacin to blood of the patients could normalize platelets count. Amikacin could inhibit platelet agglutination and dissociate agglutination, which may re-late to inhibiting activation of CD62p on platelet membrane by amikacin.%目的:研究阿米卡星在多抗凝剂依赖性假性血小板减少症中抑制血小板聚集的机制。方法:采集1例乙二胺四乙酸(edathamil,EDTA)依赖性假性血小板减少症患者的乙二胺四乙酸二钾(EDTA-K2)及枸橼酸钠抗凝血,在不同时间段分别加入阿米卡星,依次用血细胞分析仪进行血小板计数,并行血涂片镜检,用流式细胞仪检测血小板膜表面标志物CD61、CD42b、PAC-1、CD62p的表达率。结果:采血后1 h内在EDTA-K2抗凝血中加入阿米卡星,能在不影响其他血细胞形态和分布的情况下,抑制

  12. Random iteration with place dependent probabilities

    CERN Document Server

    Kapica, R

    2011-01-01

    Markov chains arising from random iteration of functions $S_{\\theta}:X\\to X$, $\\theta \\in \\Theta$, where $X$ is a Polish space and $\\Theta$ is arbitrary set of indices are considerd. At $x\\in X$, $\\theta$ is sampled from distribution $\\theta_x$ on $\\Theta$ and $\\theta_x$ are different for different $x$. Exponential convergence to a unique invariant measure is proved. This result is applied to case of random affine transformations on ${\\mathbb R}^d$ giving existence of exponentially attractive perpetuities with place dependent probabilities.

  13. Restless legs syndrome in opioid dependent patients

    Directory of Open Access Journals (Sweden)

    Abhishek Ghosh

    2014-01-01

    Full Text Available Although frequently underdiagnosed, several epidemiological studies have estimated the prevalence of restless legs syndrome (RLS in western countries at 5-15% of the general population. The diagnosis is usually made on a clinical basis, according to the criteria established by the international RLS study group. There are case reports of transient RLS in opiate withdrawal. We describe three opiate (dextropropoxyphene (DPP dependent young male patients; two of them had DPP intoxication/withdrawal seizure developing RLS during opiate withdrawal. However, their RLS persisted even after the remission of other withdrawal symptoms. Thyroid function test, hemogram, serum ferritin were normal in all of them. The cases responded well to a treatment with ropinirole. Hence, there might be a causal association, which required further well-designed studies to substantiate. The sleep disturbances and use of benzodiazepines can be minimized by increasing clinician′s sensitivity to diagnose RLS.

  14. Collaborative Modeling to Assess Drought   Resiliency of Snow‐Fed River Dependent  Communities in the Western United States:   A Case Study in the Truckee‐Carson River System

    Directory of Open Access Journals (Sweden)

    Loretta Singletary

    2017-02-01

    Full Text Available Assessing the drought resilience of snow‐fed river dependent communities in the arid  Western United States has taken on critical importance in response to changing climatic conditions.  The process of assessing drought resiliency involves understanding the extent to which snow‐fed  dependent communities can absorb the effects of uncertain and variable water supplies while  acknowledging and encouraging their capacity for adaptation. Participatory research approaches  are particularly well suited to assess resiliency in this context because they rely upon local water  managers’ knowledge and perspectives. The research presented here provides measured insight  into local water managers’ perceptions of drought resiliency in the Truckee‐Carson River System in  northwestern Nevada. These findings are reported in the context of the collaborative modeling  research design developed for this case study. The objectives of this study are: (1 to define  resiliency and present a rationale for a participatory approach to assess drought resiliency in  snow‐fed arid river basins in the Western United States; (2 to outline collaborative modeling as a  participatory research design developed for the Truckee‐Carson River System case study area; (3  to  describe  the  development and implementation of a resiliency  assessment  undertaken  to  implement this research design; (4 to highlight selected results of the assessment, summarizing  interviews with 66 water managers in the case study area; (5 to discuss the use of assessment  findings to inform collaborative modeling toward adaptation strategies; and (6 to review lessons  learned  to  date  from  the  collaborative  modeling  case  study  and  note

  15. Regional Odontodysplasia: A Case Report

    Directory of Open Access Journals (Sweden)

    Saadettin Dagistan

    2009-12-01

    Full Text Available Regional odontodysplasia (RO is a rare developmental dental anomaly with an unknown etiology. It is more often seen in girls than boys. Treatment of RO depends on the individual case. The aims of treatment should include aiding mastication and speech, improving aesthetics, reducing the psychological impact of the anomaly, allowing normal jaw growth and development, and if possible protection of any erupted teeth which are affected. We present a rare case of RO together with the treatment modality undertaken.

  16. Studies of Spuriously Time-dependent Resonances in Time-dependent Density Functional Theory

    CERN Document Server

    Luo, Kai; Maitra, Neepa T

    2016-01-01

    Adiabatic approximations in time-dependent density functional theory (TDDFT) will in general yield unphysical time-dependent shifts in the resonance positions of a system driven far from its ground-state. This spurious time-dependence is rationalized in [J. I. Fuks, K. Luo, E. D. Sandoval and N. T. Maitra, Phys. Rev. Lett. {\\bf 114}, 183002 (2015)] in terms of the violation of an exact condition by the non-equilibrium exchange-correlation kernel of TDDFT. Here we give details on the derivation and discuss reformulations of the exact condition that apply in special cases. In its most general form, the condition states that when a system is left in an arbitrary state, in the absence of time-dependent external fields nor ionic motion, the TDDFT resonance position for a given transition is independent of the state. Special cases include the invariance of TDDFT resonances computed with respect to any reference interacting stationary state of a fixed potential, and with respect to any choice of appropriate stationa...

  17. Of what is this a case?

    DEFF Research Database (Denmark)

    Lund, Christian

    2014-01-01

    Case studies are often presented as self-evident. However, of what the material is a case is actually less evident. It is argued in this article that the analytical movements of generalization, specification, abstraction, and concretization can make us more conscious of what our work might...... be a case, and that the same data have the potential to make different cases depending on these analytical movements. An analytical matrix is developed, and the four movements and various pitfalls are discussed...

  18. Pyridoxine-dependent seizures in an older child.

    Science.gov (United States)

    Yoshikawa, H; Abe, T; Oda, Y

    1999-10-01

    The case of a 12-year-old girl with pyridoxine-dependent seizures is reported. She developed status epilepticus just after birth and ordinary antiepileptic drugs were administered without effect. Her seizures ceased only on the administration of pyridoxine. Status epilepticus associated with the withdrawal of pyridoxine occurred three times, and ceased only after the renewed administration of pyridoxine. She now has mental retardation and mild spastic diplegia. The reported cases of pyridoxine-dependent seizures usually have been neonates and infants. Older patients were not fully investigated, and so we have reviewed these cases of pyridoxine-dependent seizures. As known previously, pediatricians should not forget that pyridoxine should be continued for life.

  19. Inter-dependence not Over-dependence: Reducing Urban Transport Energy Dependence

    Energy Technology Data Exchange (ETDEWEB)

    Saunders, Michael James; Rodrigues da Silva, Antonio Nelson

    2007-07-01

    A major issue of concern in today's world is urban transport energy dependence and energy supply security. In an energy inter-dependent world, energy over-dependence brings risks to urban transport systems. Many urban areas are over-dependent on finite petroleum resources for transport. New technology and the development and integration of renewable resources into transport energy systems may reduce some of the current transport energy dependence of urban areas. However, the most effective means of reducing energy dependence is to first design urban areas for this condition. An urban policy framework is proposed that requires transport energy dependence to be measured and controlled in the urban development process. A new tool has been created for this purpose, the Transport Energy Specification (TES), which measures transport energy dependence of urban areas. This creates the possibility for cities to regulate urban development with respect to energy dependence. Trial assessments were performed in Germany, New Zealand and Brazil; initial analysis by transport and government professionals shows promise of this tool being included into urban policy. The TES combined with a regulatory framework has the potential to significantly reduce transport energy consumption and dependence in urban areas in the future. (auth)

  20. 复方甘草酸苷片联合胶原蛋白面膜治疗面部激素依赖性皮炎80例疗效观察%Efficacy observation on glycyrrhizin tablets joint collagen facial mask treatment of 80 ca-ses Hormone-Dependent Dermatitis

    Institute of Scientific and Technical Information of China (English)

    张红明; 李静; 孙嘉俊; 王雪松

    2014-01-01

    AIM:To observe treatment effect of facial glycyrrhi-zin tablets joint collagen mask on Hormone-Dependent Dermatitis and to provide clinical help and guidance.METHODS:The 80 cases of our hospital from June 2013 to June 2014 with Hormone-Dependent Dermatitis were randomly divided into treatment group and control group.The control group received collagen mask treat-ment,20 ~30 min /time,one time /day,continuously use of two weeks;treatment group received collagen mask treatment based on the use of glycyrrhizin tablets (named Paiganneng,Lijun Pharmaceutical)2 tablets/time,3 times/day,orally.After 6 weeks' treatment efficacy of the two groups were observed.RE-SULTS:In the control group,the total effective rate was 45%, while the treatment group was up to 87.5%,the difference was statistically significant (P<0.05).Two groups of patients' cured rate,valid rate,invalid rate,had statistically significant differ-ence (χ2 =16.1565,P<0.01).The control group and the treat-ment group each had three cases of patients with symptoms of a slight decrease in serum potassium,oral potassium remission. CONCLUSION:Glycyrrhizin tablets joint collagen dressings mask for the treatment of Hormone-Dependent Dermatitis,can not only improve the skin symptoms,but also increase the anti-in-flammatory and anti-allergic effects,two drugs used in combina-tion can improve the therapeutic effect,and reduce the incidence of adverse reactions.%目的:观察复方甘草酸苷片联合胶原蛋白面膜治疗面部激素依赖性皮炎的效果,为临床提供帮助和指导.方法:将我院2013-06/2014-06皮肤科门诊收治的80例面部激素依赖性皮炎患者随机分为治疗组和对照组,对照组给予胶原蛋白面膜治疗,20~30 min/次,1次/d,连续使用两周;治疗组在对照组胶原蛋白面膜治疗基础上加用复方甘草酸苷片(商品名派甘能、丽君制药)2片/次、3次/d,口服.治疗6周后,观察两组

  1. Dermatology case

    Directory of Open Access Journals (Sweden)

    Sandrina Carvalho

    2016-03-01

    Full Text Available Pilomatrixoma is a benign tumor of skin appendages with follicular differentiation most frequently found in children and adolescents, predominantly female. Clinically it is characterized by an erythematous-violaceous mobile nodule of hard consistency located on the head or neck. Although rare, multiple pilomatrixomas can be associated with other pathologies, particularly myotonic dystrophy or Steinert’s disease. In these cases, a prolonged follow-up should be maintained to rule out relapses and/or development of other diseases. We describe the case of a 9-year-old girl with multiple pilomatrixomas.

  2. Case work

    DEFF Research Database (Denmark)

    Shaw, Ian Frank

    2016-01-01

    Answers to the question just what is the ?case? partly defined the fields of sociology and social work in early 20th century Chicago. Drawing on the archives of the University of Chicago, I describe and appraise the way the ?case? figured in social work at Chicago and elsewhere. I ask...... the corresponding question of sociology. Finally, I briefly consider why not much came of social work and sociology ploughing similar territory in ways that served for a time to hallmark their identities. This analysis opens up ways of rethinking how social work and sociological research are distinctive...

  3. The Copenhagen Dependency Treebank (CDT)

    DEFF Research Database (Denmark)

    Høeg Müller, Henrik; Korzen, Iørn

    2014-01-01

    the fundamentals of how CDT is marked up with semantic relations in accordance with the dependency principles governing the annotation on the other levels of CDT. Specifically, focus will be on how Generative Lexicon (GL) theory has been incorporated into the unitary theoretical dependency framework of CDT...

  4. Time-Dependent BPS Skyrmions

    CERN Document Server

    Ioannidou, Theodora

    2016-01-01

    An extended version of the BPS Skyrme model that admits time-dependent solutions is discussed. Initially, by introducing a power law at the original potential term of the BPS Skyrme model the existence, stability and structure of the corresponding solutions is investigated. Then, the frequencies and half-lifes of the radial oscillations of the constructed time-dependent solutions are determined.

  5. Two Generations of Path Dependence

    DEFF Research Database (Denmark)

    Madsen, Mogens Ove

      Even if there is no fully articulated and generally accepted theory of Path Dependence it has eagerly been taken up across a wide range of social sciences - primarily coming from economics. Path Dependence is most of all a metaphor that offers reason to believe, that some political, social...

  6. A case of inflammatory ascites

    Directory of Open Access Journals (Sweden)

    Marco Biolato

    2008-03-01

    Full Text Available Even ascites appears mainly as sign of portal hypertension in patiens with liver cirrhosis, in some case depends on a different lying condition such as right congestive heart failure, peritoneal carcinomatosis or tuberculosis. In these cases, paracentesis represents the key tool for diagnosis. We report a case of cardiac ascites in a 71-years-old woman who developed in four-month an abdominal distension. Preliminary exams showed exudative ascites related to portal hypertension, a pelvic mass with caseous apparence, and inflammatory status ad an elevation of CA-125. Successive evaluation exluded peritoneal carcinomatosis or tuberculosis, underlyng a tricuspidal regurgitation. The literature on ascites has also been reviewed.

  7. Case report

    African Journals Online (AJOL)

    ebutamanya

    2015-02-27

    Feb 27, 2015 ... Key words: Headache, spinal analgesia, epidural anaesthesia, post-dural ... Clinical features the typical positional headache, a procession of ... The immediate postoperative analgesia was ... However, the day after surgery, the patient complained of ... In case of epidural analgesia, a prophylactic blood.

  8. Case report

    African Journals Online (AJOL)

    abp

    16 déc. 2015 ... C'est un cancer à évolution locorégionale, rarement extra pelvienne ... carcinomateux TTF1 négatif, p63 négatif et p16 fortement positif compatible .... cervix presenting as lymphangiticcarcinomatosis: a case report and reviex ...

  9. Cases Description

    DEFF Research Database (Denmark)

    Hansen, Jesper Rohr; Savini, Federico; Wallin, Sirkku

    2013-01-01

    The JPI Urban Europe research project ‘APRILab’ focuses on planning dilemmas for the transformation of city areas in the urban fringe. In this Working Document we describe the case studies selected by the involved partners: - Aalto University, Finland: T3 in Espoo City - Aalborg University, Denmark...

  10. Case study

    DEFF Research Database (Denmark)

    Milana, Marcella; Bernt Sørensen, Tore

    that time Roskilde University Centre and Learning Lab Denmark, DK)3. The case here presented is based on results from research activity carried out over a 1 year period (spring 2006 - spring 2007). Detailed information concerning participation in the project was collected in two DHSs only: the Sports Day...

  11. Case report

    African Journals Online (AJOL)

    abp

    15 juin 2017 ... Primary squamous cell carcinoma of the colon: about a case .... des cancers extradigestifs ; des cas de carcinomes ovarien, endométrial, prostatique et ... tumeur (peu différenciée et indifférenciée) et le stade IV de TNM. [1,10].

  12. Case report

    African Journals Online (AJOL)

    abp

    2015-11-24

    Nov 24, 2015 ... the first molecularly confirmed case of FOP in sub-Saharan Africa outside South ... She is the seventh child in her family of eight children and the only affected in ... mobility, weight loss due to ankylosis of the jaw and thoracic.

  13. Case competitions

    DEFF Research Database (Denmark)

    Schjoldager, Anne Gram

    2009-01-01

    The paper presents and discusses a teaching project with case competitions for MA students of specialised translation at the Aarhus School of Business, Aarhus University. Drawing on a series of online questionnaires, the paper ascertains how the project was evaluated by the participating students...

  14. Case competitions

    DEFF Research Database (Denmark)

    Schjoldager, Anne Gram

    2009-01-01

    The paper presents and discusses a teaching project with case competitions for MA students of specialised translation at the Aarhus School of Business, Aarhus University. Drawing on a series of online questionnaires, the paper ascertains how the project was evaluated by the participating students...

  15. [Proliferative diabetic retinopathy -- therapeutic approach (clinical case)].

    Science.gov (United States)

    Burcea, M; Muşat, Ovidiu; Mahdi, Labib; Gheorghe, Andreea; Spulbar, F; Gobej, I

    2014-01-01

    We present the case of a 54 year old pacient diagnosed with neglected insulin dependent diabetes and proliferative diabetic retinopathy. Surgery was recommended and we practiced posterior vitrectomy, endolaser and heavy silicone oil endotamponade. Post-operative evolution was favorable.

  16. Dependency in Critically Ill Patients

    Directory of Open Access Journals (Sweden)

    Rumei Yang

    2016-03-01

    Full Text Available By necessity, critically ill patients admitted to intensive care units (ICUs have a high level of dependency, which is linked to a variety of negative feelings, such as powerlessness. However, the term dependency is not well defined in the critically ill patients. The concept of “dependency” in critically ill patients was analyzed using a meta-synthesis approach. An inductive process described by Deborah Finfgeld-Connett was used to analyze the data. Overarching themes emerged that reflected critically ill patients’ experience and meaning of being in dependency were (a antecedents: dependency in critically ill patients was a powerless and vulnerable state, triggered by a life-threatening crisis; (b attributes: the characteristic of losing “self” was featured by dehumanization and disembodiment, which can be alleviated by a “self”-restoring process; and (c outcomes: living with dependency and coping with dependency. The conceptual model explicated here may provide a framework for understanding dependency in critically ill patients.

  17. Dependency in Critically Ill Patients

    Directory of Open Access Journals (Sweden)

    Rumei Yang

    2016-03-01

    Full Text Available By necessity, critically ill patients admitted to intensive care units (ICUs have a high level of dependency, which is linked to a variety of negative feelings, such as powerlessness. However, the term dependency is not well defined in the critically ill patients. The concept of “dependency” in critically ill patients was analyzed using a meta-synthesis approach. An inductive process described by Deborah Finfgeld-Connett was used to analyze the data. Overarching themes emerged that reflected critically ill patients’ experience and meaning of being in dependency were (a antecedents: dependency in critically ill patients was a powerless and vulnerable state, triggered by a life-threatening crisis; (b attributes: the characteristic of losing “self” was featured by dehumanization and disembodiment, which can be alleviated by a “self”-restoring process; and (c outcomes: living with dependency and coping with dependency. The conceptual model explicated here may provide a framework for understanding dependency in critically ill patients.

  18. Communication imperialism and dependency: a conceptual clarification.

    Science.gov (United States)

    Lee, P S

    1988-01-01

    Communications imperialism has to do with the domination of a country's media activities by another. The ownership, structure, distribution or content of the media in 1 country are affected by pressures from media interests of another country or group out of proportion with those of that country. To determine if this is happening we should consider the country's policies, the private sector;s efforts to export communications elements, and actions of the dominant country against the dominated. The 4 aspects of international media in this situation are television program exportation, foreign ownership and control of media distribution, the infringement of capital opinions on other societies, and the transfer of commercialism and broadcasting norms. In addition to the software and hardware and the other forms of communication such as satellites, computers, and transportation of the mass media, there are the cultural effects on the developing countries. In the case of involuntary of voluntary dependency of the recipient country, the effect of the unbalanced international communication can be harmful or beneficial. Communication dependency may not be harmful to the culture of the recipient country. In determining the theory of unbalanced international communications 3 factors should be considered. There are: the role of the interacting countries, the nature of the dependency of the recipient country, and the beneficial or harmful effect of unbalanced communication pattern on that country.

  19. Quintessential scale dependence from separate universe simulations

    Science.gov (United States)

    Chiang, Chi-Ting; Li, Yin; Hu, Wayne; LoVerde, Marilena

    2016-12-01

    By absorbing fluctuations into a local background, separate universe simulations provide a powerful technique to characterize the response of small-scale observables to the long-wavelength density fluctuations, for example those of the power spectrum and halo mass function which lead to the squeezed-limit n -point function and halo bias, respectively. Using quintessence dark energy as the paradigmatic example, we extend these simulation techniques to cases where non-gravitational forces in other sectors establish a Jeans scale across which the growth of density fluctuations becomes scale dependent. By characterizing the separate universes with matching background expansion histories, we show that the power spectrum and mass function responses depend on whether the long-wavelength mode is above or below the Jeans scale. Correspondingly, the squeezed bispectrum and halo bias also become scale dependent. Models of bias that are effectively local in the density field at a single epoch, initial or observed, cannot describe this effect which highlights the importance of temporal nonlocality in structure formation. Validated by these quintessence tests, our techniques are applicable to a wide range of models where the complex dynamics of additional fields affect the clustering of matter in the linear regime and it would otherwise be difficult to simulate their impact in the nonlinear regime.

  20. Dissipative time-dependent quantum transport theory.

    Science.gov (United States)

    Zhang, Yu; Yam, Chi Yung; Chen, GuanHua

    2013-04-28

    A dissipative time-dependent quantum transport theory is developed to treat the transient current through molecular or nanoscopic devices in presence of electron-phonon interaction. The dissipation via phonon is taken into account by introducing a self-energy for the electron-phonon coupling in addition to the self-energy caused by the electrodes. Based on this, a numerical method is proposed. For practical implementation, the lowest order expansion is employed for the weak electron-phonon coupling case and the wide-band limit approximation is adopted for device and electrodes coupling. The corresponding hierarchical equation of motion is derived, which leads to an efficient and accurate time-dependent treatment of inelastic effect on transport for the weak electron-phonon interaction. The resulting method is applied to a one-level model system and a gold wire described by tight-binding model to demonstrate its validity and the importance of electron-phonon interaction for the quantum transport. As it is based on the effective single-electron model, the method can be readily extended to time-dependent density functional theory.

  1. Motor skill depends on knowledge of facts.

    Science.gov (United States)

    Stanley, Jason; Krakauer, John W

    2013-01-01

    Those in 20th century philosophy, psychology, and neuroscience who have discussed the nature of skilled action have, for the most part, accepted the view that being skilled at an activity is independent of knowing facts about that activity, i.e., that skill is independent of knowledge of facts. In this paper we question this view of motor skill. We begin by situating the notion of skill in historical and philosophical context. We use the discussion to explain and motivate the view that motor skill depends upon knowledge of facts. This conclusion seemingly contradicts well-known results in cognitive science. It is natural, on the face of it, to take the case of H.M., the seminal case in cognitive neuroscience that led to the discovery of different memory systems, as providing powerful evidence for the independence of knowledge and skill acquisition. After all, H.M. seems to show that motor learning is retained even when previous knowledge about the activity has been lost. Improvements in skill generally require increased precision of selected actions, which we call motor acuity. Motor acuity may indeed not require propositional knowledge and has direct parallels with perceptual acuity. We argue, however, that reflection on the specifics of H.M.'s case, as well as other research on the nature of skill, indicates that learning to become skilled at a motor task, for example tennis, depends also on knowledge-based selection of the right actions. Thus skilled activity requires both acuity and knowledge, with both increasing with practice. The moral of our discussion ranges beyond debates about motor skill; we argue that it undermines any attempt to draw a distinction between practical and theoretical activities. While we will reject the independence of skill and knowledge, our discussion leaves open several different possible relations between knowledge and skill. Deciding between them is a task to be resolved by future research.

  2. Glucose-dependent insulinotropic polypeptide

    DEFF Research Database (Denmark)

    Christensen, Mikkel; Vedtofte, Louise; Holst, Jens Juul

    2011-01-01

    OBJECTIVE To evaluate the glucose dependency of glucose-dependent insulinotropic polypeptide (GIP) effects on insulin and glucagon release in 10 healthy male subjects ([means ± SEM] aged 23 ± 1 years, BMI 23 ± 1 kg/m2, and HbA1c 5.5 ± 0.1%). RESEARCH DESIGN AND METHODS Saline or physiological doses....... In contrast, GIP increases glucagon levels during fasting and hypoglycemic conditions, where it has little or no effect on insulin secretion. Thus, GIP seems to be a physiological bifunctional blood glucose stabilizer with diverging glucose-dependent effects on the two main pancreatic glucoregulatory hormones....

  3. Topology optimised wavelength dependent splitters

    DEFF Research Database (Denmark)

    Hede, K. K.; Burgos Leon, J.; Frandsen, Lars Hagedorn

    A photonic crystal wavelength dependent splitter has been constructed by utilising topology optimisation1. The splitter has been fabricated in a silicon-on-insulator material (Fig. 1). The topology optimised wavelength dependent splitter demonstrates promising 3D FDTD simulation results....... This complex photonic crystal structure is very sensitive against small fabrication variations from the expected topology optimised design. A wavelength dependent splitter is an important basic building block for high-performance nanophotonic circuits. 1J. S. Jensen and O. Sigmund, App. Phys. Lett. 84, 2022...

  4. A Theory of Service Dependency

    Directory of Open Access Journals (Sweden)

    Mats Neovius

    2016-06-01

    Full Text Available Service composition has become commonplace nowadays, in large part due to the increased complexity of software and supporting networks. Composition can be of many types, for instance sequential, prioritising, non-deterministic. However, a fundamental feature of the services to be composed consists in their dependencies with respect to each other. In this paper we propose a theory of service dependency, modelled around a dependency operator in the Action Systems formalism. We analyze its properties, composition behaviour, and refinement conditions with accompanying examples.

  5. Mastering Ninject for dependency injection

    CERN Document Server

    Baharestani, Daniel

    2013-01-01

    Mastering Ninject for Dependency Injection teaches you the most powerful concepts of Ninject in a simple and easy-to-understand format using lots of practical examples, diagrams, and illustrations.Mastering Ninject for Dependency Injection is aimed at software developers and architects who wish to create maintainable, extensible, testable, and loosely coupled applications. Since Ninject targets the .NET platform, this book is not suitable for software developers of other platforms. Being familiar with design patterns such as singleton or factory would be beneficial, but no knowledge of depende

  6. Topology optimised wavelength dependent splitters

    DEFF Research Database (Denmark)

    Hede, K. K.; Burgos Leon, J.; Frandsen, Lars Hagedorn;

    A photonic crystal wavelength dependent splitter has been constructed by utilising topology optimisation1. The splitter has been fabricated in a silicon-on-insulator material (Fig. 1). The topology optimised wavelength dependent splitter demonstrates promising 3D FDTD simulation results....... This complex photonic crystal structure is very sensitive against small fabrication variations from the expected topology optimised design. A wavelength dependent splitter is an important basic building block for high-performance nanophotonic circuits. 1J. S. Jensen and O. Sigmund, App. Phys. Lett. 84, 2022...

  7. Visualizing Influential Observations in Dependent Data

    KAUST Repository

    Genton, Marc G.

    2010-01-01

    We introduce the hair-plot to visualize influential observations in dependent data. It consists of all trajectories of the value of an estimator when each observation is modified in turn by an additive perturbation. We define two measures of influence: the local influence which describes the rate of departure from the original estimate due to a small perturbation of each observation; and the asymptotic influence which indicates the influence on the original estimate of the most extreme contamination for each observation. The cases of estimators defined as quadratic forms or ratios of quadratic forms are investigated in detail. Sample autocovariances, covariograms, and variograms belong to the first case. Sample autocorrelations, correlograms, and indices of spatial autocorrelation such as Moran\\'s I belong to the second case.We illustrate our approach on various datasets from time series analysis and spatial statistics. This article has supplementary material online. © 2010 American Statistical Association, Institute of Mathematical Statistics, and Interface Foundation of North America.

  8. A Case for Case Report

    Directory of Open Access Journals (Sweden)

    Vivek Gharpure

    2010-11-01

    Full Text Available Evidence based medicine (EBM is becoming popular among clinicians and medical publishers; as clinical research is tested against the touchstone of EBM. Theory of Quality of Evidence, considers randomized controlled trials to be the best quality evidence, while case reports and expert opinions are considered at the lowest ebb

  9. Corruption case.

    Science.gov (United States)

    1999-07-23

    A Federal jury in Puerto Rico found three defendants guilty of participating in the theft of $2.2 million in Federal funds from the San Juan AIDS Institute. The key figure in the case is [name removed], a consultant to the institute. He was convicted of 12 counts of money laundering and faces up to 25 years in prison. Two other administrative officials were also convicted in the case. Four others have pleaded guilty, and three more await trial. Rep. Jose Granados Navado was among those implicated; he received $100,000 for his campaign for mayor of San Juan in 1988 from the institute=s medical director. U.S. Rep. Tom Coburn (R-Okla.) has called for an audit of all Ryan White CARE Act funds since this scandal was uncovered.

  10. ANABOLIC ANDROGENIC STEROIDS AND DEPENDENCE

    Directory of Open Access Journals (Sweden)

    IHSAN SARI

    2010-12-01

    Full Text Available Anabolic androgenic steroids are used for sportive, cosmetic, therapeutic and occupational reasons and there are many side effects reported (George, 2005; Nieminen et al., 1996; O'Sullivan et al., 2000. Prevalence of anabolic steroids’ use also indicates the importance of this topic. Moreover, it is now known that use of anabolic steroids could lead to dependence which could be psychological or/and physiological (Copeland et al., 2000. It isimportant to know about all aspects of anabolic steroids including dependence. Therefore, this study has attempted to give an insight into use of anabolic steroids and dependence. The discussion will focus on prevalence, reasons, and side effects of use and physiological and psychological dependence

  11. Modeling Dependencies in Critical Infrastructures

    NARCIS (Netherlands)

    Nieuwenhuijs, A.H.; Luiijf, H.A.M.; Klaver, M.H.A.

    2009-01-01

    This paper describes a model for expressing critical infrastructure dependencies. The model addresses the limitations of existing approaches with respect to clarity of definition, support for quality and the influence of operating states of critical infrastructures and environmental factors.

  12. Trust, dependence and interorganizational systems

    NARCIS (Netherlands)

    Ibrahim, M.K.M.

    2006-01-01

    Organizations form interorganizational relationships and utilize information technology to improve performance. This thesis discusses the influences of dependence and different types of trust on the use of interorganizational systems and subsequently the attainment of strategic benefits. The finding

  13. On time dependent Ekman transports

    National Research Council Canada - National Science Library

    Roed, L.P

    1973-01-01

    One of the most cited papers in ocean current theories is the paper by Ekman (1905). Here we take his paper as a starting point for computing time dependent solutions for the integrated velocities or the transports.

  14. Alcohol dependence--classificatory considerations.

    Science.gov (United States)

    Lesch, O M; Ades, J; Badawy, A; Pelc, I; Sasz, H

    1993-01-01

    The term alcoholism or alcohol dependence has acquired a broad range of meanings. The Plinius Maior Society herewith presents new classificatory considerations and suggests additional recording of special dimensions according to the individual hypothesis and design of a study.

  15. Time-Dependent Lagrangian Biomechanics

    CERN Document Server

    Ivancevic, Tijana T

    2009-01-01

    In this paper we present the time-dependent generalization of an 'ordinary' autonomous human musculo-skeletal biomechanics. We start with the configuration manifold of human body, given as a set of its all active degrees of freedom (DOF). This is a Riemannian manifold with a material metric tensor given by the total mass-inertia matrix of the human body segments. This is the base manifold for standard autonomous biomechanics. To make its time-dependent generalization, we need to extend it with a real time axis. On this extended configuration space we develop time-dependent biomechanical Lagrangian dynamics, using derived jet spaces of velocities and accelerations, as well as the underlying geometric evolution of the mass-inertia matrix. Keywords: Human time-dependent biomechanics, configuration manifold, jet spaces, geometric evolution

  16. Radiological case

    Directory of Open Access Journals (Sweden)

    Filipe Macedo

    2016-03-01

    Full Text Available We present a case of a 15-year-old boy with sudden onset of left hip pain while playing football. The x-ray revealed an avulsion injury of the anterior inferior iliac spine. The anterior inferior iliac spine is one of the places in the pelvis where avulsion injuries can occur and is due to forceful contractions of the rectus femoris muscle.

  17. Dermatology case

    Directory of Open Access Journals (Sweden)

    Catarina Dias

    2017-01-01

    Full Text Available Glomuvenous malformations, also known as glomangiomas, are tumor-like malformations or hamartomas of the glomus body. They can be sporadic or inherited as an autosomal dominant disease. Glomuvenous malformations tend to resemble hemangiomas. Clinical distinction between these entities is important due to their different therapeutic approaches. Surgical excision is the treatment of choice for isolated, painful glomuvenous malformations. We describe a case of a 7-year-old girl with multiple glomuvenous malformations.

  18. Dermatology case

    Directory of Open Access Journals (Sweden)

    Sandrina Carvalho

    2015-12-01

    and self-limiting dermatosis with characteristic clinical and histopathological pattern that justify its designation. It is characterized by annular or arciform erythematous plaques, preferably affecting the extensor surface of upper and lower limbs of younger patients. There are four main variants of granuloma annulare: localized, generalized, subcutaneous and perforating. In childhood, localized and subcutaneous forms are most commonly observed. We describe the case of a seven-year-old girl with localized granuloma annulare.

  19. Dermatology Case

    Directory of Open Access Journals (Sweden)

    Catarina Matos

    2017-01-01

    Full Text Available The authors describe a clinical case of a 5-months-old boy with widespread rash since the first month of life. Diffuse papular rash with intensive itching. The shaved skin was inconclusive so we performed biopsy to conÞ rm the diagnosis of scabies. It’s a dermatosis very contagious caused by the mite Sarcoptes scabiei var. hominis. In infants skin eruption may have a polymorphic presentation with characteristic distribution.

  20. Case04

    DEFF Research Database (Denmark)

    Vestergaard, Flemming; Karlshøj, Jan; Hauch, Peter;

    Casestudiets formål er at beskrive og måle en større entreprenørvirksomheds omkostninger og gevin-ster ved at anvende metoder og værktøjer, der er modelbaserede. Case 04 tager udgangspunkt i et konkret byggeprojekt, hvor BIM teknologien er anvendt på et for den danske entreprenørbranche rela...

  1. Case Corabelle

    OpenAIRE

    Hansen, Casper; Henriksen, Jesper; Loznica, Javor; Ragnarsson, Stefan; Hensing, Marcus

    2015-01-01

    This project explores the relation between organizational identity and online brands as formed through interaction and communication on online, social media through a case study of the cancelled music festival event Corabelle that was supposed to have been held in August of 2014. The investigation draws on the theories of Carlos Scolari and David A. Whetten to establish the relation between organizational identity and online brands, and the theories of Henry Jenkins and Jan H. Kietzmann in an...

  2. Encouraging Cases

    DEFF Research Database (Denmark)

    Koss Rasmussen, Rasmus

    In CMS, debates on methodology have typically taken second stage to those on epistemology and ontology as the field embraced a plurality of methods. Recent work pushing for CMS to engage more strongly with mainstream theory, however, raises the need for a discussion on how to use methods recogniz......” (Schofield, 2002). In this way, employing case studies in a progressive fashion may serve as a valuable means for a critically perfomative CMS to achieve greater impact through influence on mainstream theory building, business school education and management practice.......In CMS, debates on methodology have typically taken second stage to those on epistemology and ontology as the field embraced a plurality of methods. Recent work pushing for CMS to engage more strongly with mainstream theory, however, raises the need for a discussion on how to use methods...... recognizable to the mainstream in progressive ways. This paper seeks to remedy this lacunae by linking the concept of Critical Performativity (Spicer, Alvesson & Kärreman, 2009) to case study research and shows how case studies informed by Critical Realism (Easton, 2010a) can be generalized to “what could be...

  3. Temperature dependence of heterogeneous nucleation: Extension of the Fletcher model

    Science.gov (United States)

    McGraw, Robert; Winkler, Paul; Wagner, Paul

    2015-04-01

    Recently there have been several cases reported where the critical saturation ratio for onset of heterogeneous nucleation increases with nucleation temperature (positive slope dependence). This behavior contrasts with the behavior observed in homogeneous nucleation, where a decreasing critical saturation ratio with increasing nucleation temperature (negative slope dependence) seems universal. For this reason the positive slope dependence is referred to as anomalous. Negative slope dependence is found in heterogeneous nucleation as well, but because so few temperature-dependent measurements have been reported, it is not presently clear which slope condition (positive or negative) will become more frequent. Especially interesting is the case of water vapor condensation on silver nanoparticles [Kupc et al., AS&T 47: i-iv, 2013] where the critical saturation ratio for heterogeneous nucleation onset passes through a maximum, at about 278K, with higher (lower) temperatures showing the usual (anomalous) temperature dependence. In the present study we develop an extension of Fletcher's classical, capillarity-based, model of heterogeneous nucleation that explicitly resolves the roles of surface energy and surface entropy in determining temperature dependence. Application of the second nucleation theorem, which relates temperature dependence of nucleation rate to cluster energy, yields both necessary and sufficient conditions for anomalous temperature behavior in the extended Fletcher model. In particular it is found that an increasing contact angle with temperature is a necessary, but not sufficient, condition for anomalous temperature dependence to occur. Methods for inferring microscopic contact angle and its temperature dependence from heterogeneous nucleation probability measurements are discussed in light of the new theory.

  4. Dependência de drogas

    Directory of Open Access Journals (Sweden)

    Miriam Garcia-Mijares

    2006-01-01

    Full Text Available O texto discute três teorias atuais de dependência de drogas: a Teoria Comportamental da dependência como escolha de Heyman, a Teoria da Sensibilização do incentivo de Robinson e Berridge, e a Teoria Neurobiológica da dependência como escolha, de Kalivas. Todas concordam em caracterizar a dependência como resultante de processos de aprendizagem em que droga e estímulos associados a seus efeitos adquirem controle potente sobre o comportamento. Diferenciam-se quanto aos processos de aprendizagem envolvidos. A Teoria Comportamental enfatiza componentes operantes e sustenta que o consumo repetido de drogas diminui o valor reforçador de atividades concorrentes. A Teoria da Sensibilização enfatiza componentes respondentes, propondo a dependência como resultado da sensibilização da potência eliciadora de estímulos condicionados aos efeitos da droga. A Teoria Neurobiológica integra as duas primeiras, descrevendo as mudanças no circuito do reforço que acontecem no processo de dependência.

  5. Scaling Laws for Convection with Temperature-dependent Viscosity and Grain-damage

    CERN Document Server

    Foley, Bradford J

    2014-01-01

    Numerical experiments of convection with grain-damage are used to develop scaling laws for convective heat flow, mantle velocity, and plate velocity across the stagnant lid and plate-tectonic regimes. Three main cases are presented in order of increasing complexity: a simple case wherein viscosity is only dependent on grainsize, a case where viscosity depends on temperature and grainsize, and finally a case where viscosity is temperature and grainsize sensitive, and the grain-growth (or healing) is also temperature sensitive. In all cases, convection with grain-damage scales differently than Newtonian convection due to the effects of grain-damage. For the fully realistic case, numerical results show stagnant lid convection, fully mobilized convection that resembles the temperature-independent viscosity case, and partially mobile or transitional convection, depending on damage to healing ratio, Rayleigh number, and the activation energies for viscosity and healing. Applying our scaling laws for the fully reali...

  6. Comparative Survey of Mental Disorders and Personality Characteristics in Persons With Drug Dependent and Non Drug Dependent in Hamadan, Iran

    Directory of Open Access Journals (Sweden)

    A. Ghaleiha

    2008-07-01

    Full Text Available Introduction & Objective: The influence of genetic, biological, psychological, social and cultural factors on drug dependency and high rate comorbidity of this phenomenon with psychiatric disorders for example anxiety, depression and characteristics and personality disorders is emphasized. The aim of this study was the comparative investigation of mental disorders and personality traits in persons with drug dependent and non drug dependent in Hamadan city in 2001-2003 .Materials & Methods: Present research was a descriptive comparison and subjects were 100 drug dependent persons and 100 non drug dependent individuals .Case group was chosen through available sampling among persons who call on psychiatrist and control group was chosen through randomly simple sampling from general population. Measurement and diagnostic tools includes questionnaire for examining demographic characteristics, designed by researchers and MMPI, SCL90-R tests and DSM IV criteria diagnostic and also T test that was used for analyzing data.Results: Between two groups in clinical and validity scales of MMPI test expect for hypochondriasis and hysteria and scales of SCL 90-R test expect somatization and interpersonal sensitivity differences were statistically significant (P<0.05.Conclusion: We can conclude that persons with drug dependent display more signs of psychopathology and mental disorders in comparison with non drug dependent people and Major depressive disorder and personality disorder were frequent among drug dependent groups. Depression and personal disorders were frequent in non drug dependent persons too. Our results support the results of previous studies.

  7. Path dependence of truss-like mixed mode cohesive laws

    DEFF Research Database (Denmark)

    Goutianos, Stergios; Sørensen, Bent F.

    2012-01-01

    A general theoretical analysis is presented to prove that, under mixed mode fracture, truss-like mixed mode cohesive laws (cohesive laws that are coupled in a special manner such that the traction vector follows the separation/opening vector) are path independent only in the limited case where th...... and numerically that these cohesive laws are path dependent....

  8. Ultrasound attenuation dependence on air compression or expansion processes

    NARCIS (Netherlands)

    Jakevicius, L.; Demcenko, A.; Mardosaite, R.

    2010-01-01

    In this work variation of ultrasonic attenuation coefficient is analyzed in terms of air compression or expansion processes. In closed spaces changing air volume, the ultrasound attenuation coefficient depends on thermodynamic processes which occur during the air volume change. Two limiting cases ar

  9. Long memory and tail dependence in trading volume and volatility

    DEFF Research Database (Denmark)

    Rossi, Eduardo; Santucci de Magistris, Paolo

    2013-01-01

    We investigate the relationship between volatility, measured by realized volatility, and trading volume for 25 NYSE stocks. We show that volume and volatility are long memory but not fractionally cointegrated in most cases. We also find right tail dependence in the volatility and volume innovations...

  10. Wigner law for matrices with dependent entries - a perturbative approach

    CERN Document Server

    Krajewski, T; Vu, D L

    2016-01-01

    We show that Wigner semi-circle law holds for Hermitian matrices with dependent entries, provided the deviation of the cumulants from the normalised Gaussian case obeys a simple power law bound in the size of the matrix. To establish this result, we use replicas interpreted as a zero-dimensional quantum field theoretical model whose effective potential obey a renormalisation group equation.

  11. From IF to BI: A tale of dependence and separation

    NARCIS (Netherlands)

    Abramsky, S.; Väänänen, J.

    2009-01-01

    We take a fresh look at the logics of informational dependence and independence of Hintikka and Sandu and Väänänen, and their compositional semantics due to Hodges. We show how Hodges’ semantics can be seen as a special case of a general construction, which provides a context for a useful completene

  12. Long memory and tail dependence in trading volume and volatility

    DEFF Research Database (Denmark)

    Rossi, Eduardo; Santucci de Magistris, Paolo

    2013-01-01

    We investigate the relationship between volatility, measured by realized volatility, and trading volume for 25 NYSE stocks. We show that volume and volatility are long memory but not fractionally cointegrated in most cases. We also find right tail dependence in the volatility and volume innovations...

  13. Extracting Credible Dependencies for Averaged One-Dependence Estimator Analysis

    Directory of Open Access Journals (Sweden)

    LiMin Wang

    2014-01-01

    Full Text Available Of the numerous proposals to improve the accuracy of naive Bayes (NB by weakening the conditional independence assumption, averaged one-dependence estimator (AODE demonstrates remarkable zero-one loss performance. However, indiscriminate superparent attributes will bring both considerable computational cost and negative effect on classification accuracy. In this paper, to extract the most credible dependencies we present a new type of seminaive Bayesian operation, which selects superparent attributes by building maximum weighted spanning tree and removes highly correlated children attributes by functional dependency and canonical cover analysis. Our extensive experimental comparison on UCI data sets shows that this operation efficiently identifies possible superparent attributes at training time and eliminates redundant children attributes at classification time.

  14. Frequency dependent changes in NMDAR-dependent synaptic plasticity

    Directory of Open Access Journals (Sweden)

    Arvind eKumar

    2011-09-01

    Full Text Available The NMDAR-dependent synaptic plasticity is thought to mediate several forms of learning, and can be induced by spike trains containing a small number of spikes occurring with varying rates and timing, as well as with oscillations. We computed the influence of these variables on the plasticity induced at a single NMDAR containing synapse using a reduced model that was analytically tractable, and these findings were confirmed using detailed, multi-compartment model. In addition to explaining diverse experimental results about the rate and timing dependence of synaptic plasticity, the model made several novel and testable predictions. We found that there was a preferred frequency for inducing long-term potentiation (LTP such that higher frequency stimuli induced lesser LTP, decreasing as 1/f when the number of spikes in the stimulus was kept fixed. Among other things, the preferred frequency for inducing LTP varied as a function of the distance of the synapse from the soma. In fact, same stimulation frequencies could induce LTP or LTD depending on the dendritic location of the synapse. Next, we found that rhythmic stimuli induced greater plasticity then irregular stimuli. Furthermore, brief bursts of spikes significantly expanded the timing dependence of plasticity. Finally, we found that in the ~5-15Hz frequency range both rate- and timing-dependent plasticity mechanisms work synergistically to render the synaptic plasticity most sensitive to spike-timing. These findings provide computational evidence that oscillations can have a profound influence on the plasticity of an NMDAR-dependent synapse, and show a novel role for the dendritic morphology in this process.

  15. Form-preserving transformations of the time-dependent Klein-Gordon equation and the generation of solvable potentials

    Energy Technology Data Exchange (ETDEWEB)

    Schulze-Halberg, Axel [Department of Science, University of Colima, Bernal Diaz del Castillo 340, Col. Villas San Sebastian, C.P. 28045, Colima, Col. (Mexico)

    2006-10-15

    A form-preserving transformation for the time-dependent Klein-Gordon equation (TKGE) is derived. Existence of the transformation depends strongly on the shape of the vector and scalar potentials in the TKGE. We discuss the special case of the transformation between the TKGE and the stationary Klein-Gordon equation, which can be used to generate time-dependent solvable cases out of stationary solvable cases.

  16. A Finite Axiomatization of G-Dependence

    OpenAIRE

    Paolini, Gianluca

    2015-01-01

    We show that a form of dependence known as G-dependence (originally introduced by Grelling) admits a very natural finite axiomatization, as well as Armstrong relations. We also give an explicit translation between functional dependence and G-dependence.

  17. Dermatology Case

    Directory of Open Access Journals (Sweden)

    Sandrina Carvalho

    2016-09-01

    Full Text Available Connective tissue nevus (CTN is a hamartomatous growth which can be associated to multiple syndromes, such as tuberous sclerosis, Buschke-Ollendorf syndrome, or Proteus syndrome. Familial cases of CTN have also been related to cardiac disease. Classically, CTN are characterized by asymptomatic, firm, multiple, skin-colored or yellowish plaques on the trunk or limbs, arising during childhood with no gender preference. A skin biopsy is usually necessary to confirm the diagnosis. Additional studies are oriented by signs or symptoms suggesting an underlying disease.

  18. Finite element discretization of Darcy's equations with pressure dependent porosity

    KAUST Repository

    Girault, Vivette

    2010-02-23

    We consider the flow of a viscous incompressible fluid through a rigid homogeneous porous medium. The permeability of the medium depends on the pressure, so that the model is nonlinear. We propose a finite element discretization of this problem and, in the case where the dependence on the pressure is bounded from above and below, we prove its convergence to the solution and propose an algorithm to solve the discrete system. In the case where the dependence on the pressure is exponential, we propose a splitting scheme which involves solving two linear systems, but parts of the analysis of this method are still heuristic. Numerical tests are presented, which illustrate the introduced methods. © 2010 EDP Sciences, SMAI.

  19. Worst-case analysis of heap allocations

    DEFF Research Database (Denmark)

    Puffitsch, Wolfgang; Huber, Benedikt; Schoeberl, Martin

    2010-01-01

    In object oriented languages, dynamic memory allocation is a fundamental concept. When using such a language in hard real-time systems, it becomes important to bound both the worst-case execution time and the worst-case memory consumption. In this paper, we present an analysis to determine...... the worst-case heap allocations of tasks. The analysis builds upon techniques that are well established for worst-case execution time analysis. The difference is that the cost function is not the execution time of instructions in clock cycles, but the allocation in bytes. In contrast to worst-case execution...... time analysis, worst-case heap allocation analysis is not processor dependent. However, the cost function depends on the object layout of the runtime system. The analysis is evaluated with several real-time benchmarks to establish the usefulness of the analysis, and to compare the memory consumption...

  20. The psychobiology of nicotine dependence

    Directory of Open Access Journals (Sweden)

    D. J. K. Balfour

    2008-12-01

    Full Text Available There is abundant evidence to show that nicotine is the principal addictive component of tobacco smoke. The results of laboratory studies have shown that nicotine has many of the behavioural and neurobiological properties of a drug of dependence. This article focuses on the evidence that nicotine has the rewarding and reinforcing properties typical of an addictive drug and that these properties are mediated, in part, by its effects on mesolimbic dopamine neurones. However, in many experimental models of dependence, nicotine has relatively weak reinforcing properties that do not appear to explain adequately the powerful addiction to tobacco smoke experienced by many habitual smokers. Some of the reasons for this conundrum will be covered herein. This article focuses on the hypothesis that sensory stimuli and other pharmacologically active components in tobacco smoke play a pivotal role in the addiction to nicotine when it is inhaled in tobacco smoke. The article will discuss the evidence that dependence upon tobacco smoke reflects a complex interaction between nicotine and the components of the smoke, which are mediated by complementary effects of nicotine on the dopamine projections to the shell and core subdivisions of the accumbens. It will also discuss the extent to which the complexity of the dependence explains why nicotine replacement therapy does not provide a completely satisfying aid to smoking cessation and speculate on the properties treatments should exhibit if they are to provide a better treatment for tobacco dependence than those currently available.

  1. Complexity of validity for propositional dependence logics

    OpenAIRE

    Jonni Virtema

    2014-01-01

    We study the validity problem for propositional dependence logic, modal dependence logic and extended modal dependence logic. We show that the validity problem for propositional dependence logic is NEXPTIME-complete. In addition, we establish that the corresponding problem for modal dependence logic and extended modal dependence logic is NEXPTIME-hard and in NEXPTIME^NP.

  2. Dependency Structures for Statistical Machine Translation

    Science.gov (United States)

    Bach, Nguyen

    2012-01-01

    Dependency structures represent a sentence as a set of dependency relations. Normally the dependency structures from a tree connect all the words in a sentence. One of the most defining characters of dependency structures is the ability to bring long distance dependency between words to local dependency structures. Another the main attraction of…

  3. Location of gliomas in relation to mobile telephone use: a case-case and case-specular analysis

    DEFF Research Database (Denmark)

    Larjavaara, Suvi; Schüz, Joachim; Swerdlow, Anthony;

    2011-01-01

    approaches: In a case-case analysis, tumor locations were compared with varying exposure levels; in a case-specular analysis, a hypothetical reference location was assigned for each glioma, and the distances from the actual and specular locations to the handset were compared. The study included 888 gliomas......The energy absorbed from the radio-frequency fields of mobile telephones depends strongly on distance from the source. The authors' objective in this study was to evaluate whether gliomas occur preferentially in the areas of the brain having the highest radio-frequency exposure. The authors used 2...... from 7 European countries (2000-2004), with tumor midpoints defined on a 3-dimensional grid based on radiologic images. The case-case analyses were carried out using unconditional logistic regression, whereas in the case-specular analysis, conditional logistic regression was used. In the case-case...

  4. Baclofen in the short-term maintenance treatment of benzodiazepine dependence

    Directory of Open Access Journals (Sweden)

    Lekhansh Shukla

    2014-01-01

    Full Text Available Benzodiazepine (BZD dependence is a significant public health problem. Apart from the long-term tapering doses of BZD, no others drugs are available for the maintenance treatment of BZD dependence. Baclofen has been used in alcohol and other drug dependence as long-term anti-craving agent. Since alcohol and BZD act through the GABA receptor, we attempted to study the effect of Baclofen as maintenance treatment in a series of five cases with BZD dependence.

  5. A trapped ion with time-dependent frequency interaction with a laser field

    Energy Technology Data Exchange (ETDEWEB)

    MartInez, J M Vargas; Moya-Cessa, H [INAOE, Apartado Postal 51 y 216, 72000 Puebla (Mexico)

    2004-06-01

    We analyse the problem of a trapped ion with time-dependent frequency interacting with a laser field. By using a set of unitary time-dependent transformations we show that this system is equivalent to the interaction between a quantized field and a double level with time-dependent interaction parameters. In passing, we show that in the on-resonance case different vibrational transitions may be achieved by using time-dependent parameters.

  6. Baclofen in the short-term maintenance treatment of benzodiazepine dependence.

    Science.gov (United States)

    Shukla, Lekhansh; Kandasamy, Arun; Kesavan, Muralidharan; Benegal, Vivek

    2014-11-01

    Benzodiazepine (BZD) dependence is a significant public health problem. Apart from the long-term tapering doses of BZD, no others drugs are available for the maintenance treatment of BZD dependence. Baclofen has been used in alcohol and other drug dependence as long-term anti-craving agent. Since alcohol and BZD act through the GABA receptor, we attempted to study the effect of Baclofen as maintenance treatment in a series of five cases with BZD dependence.

  7. Case management.

    Science.gov (United States)

    Rosenstein, A H; Propotnik, T

    1997-03-01

    Providing cost-effective high quality healthcare services ranks as the number one concern for anyone involved with the healthcare delivery system. While quality of care should always be the number one priority, controlling healthcare costs receives most of the attention. With limited healthcare dollars and providers assuming more of the financial risk for services rendered, a whole assortment of cost-containment strategies are being introduced in an effort to maintain some semblance of financial viability. Healthcare providers can approach cost control from two different angles. On the fixed-cost operational overhead side, traditional cost-containment techniques have focused on downsizing, maximizing productivity, staffing redesign, improved purchasing contracts, standardization, inventory control, and other more individualized restructured service models. On the variable-cost clinical side, cost control has been approached by introducing a variety of cost-containment strategies designed to improve efficiency and effectiveness of provider performance. While many of these strategies, previously discussed in the Journal of Healthcare Resource Management have stressed the importance of education, guidelines, pathways, and other clinical "tools for improvement," the success of many of these tools resides in the ability to provide real-time intervention. Real-time intervention rather than the more passive retrospective variance analysis has the greatest potential for producing cost savings by actually making a recommendation that prevents the unwanted event from occurring. In many institutions, the case manager bears the responsibility for monitoring and managing these programs. This article describes various case management models currently used by different institutions.

  8. Capillary rise with velocity-dependent dynamic contact angle.

    Science.gov (United States)

    Popescu, M N; Ralston, J; Sedev, R

    2008-11-04

    The classic description of the rate of capillary rise given by the Washburn equation, which assumes that the contact angle preserves the equilibrium value at all times, has been recently questioned in the light of the known experimental dependence of the dynamic contact angle on the velocity of the contact line. For a number of such proposed functions of velocity for the dynamic contact angle, we analyze the resulting dependences of the contact angle and of the time of rise, respectively, on the height of the capillary rise. By applying our results to the particular cases of a high-viscosity silicone oil and water, respectively, in a glass capillary, we show that, in general, strong similarities arise between the various approaches and the classic theory in what concerns the time dependence of the capillary rise, which explains the lack of consistent experimental evidence for deviations in the rate of capillary rise from the Washburn equation. However, for a strong dependency of the contact angle on the velocity in the range of small velocities, as in the case of water on glass, one of the models predicts significant deviations even for the time dependence of the capillary rise. Moreover, our results show that the time or height dependence of the contact angle during the capillary rise can clearly discriminate between the various models.

  9. Anabolic steroid abuse and dependence.

    Science.gov (United States)

    Brower, Kirk J

    2002-10-01

    Anabolic-androgenic steroids (AAS) are mainly used to treat androgen deficiency syndromes and, more recently, catabolic states such as AIDS-associated wasting. There is no evidence in the reviewed literature that AAS abuse or dependence develops from the therapeutic use of AAS. Conversely, 165 instances of AAS dependence have been reported among weightlifters and bodybuilders who, as part of their weight training regimens, chronically administered supraphysiologic doses, often including combinations of injected and oral AAS as well as other drugs of abuse. A new model is proposed in which both the "myoactive" and psychoactive effects of AAS contribute to the development of AAS dependence. The adverse consequences of AAS are reviewed, as well as their assessment by means of a history and physical, mental status examination, and laboratory testing. When patients with AAS use disorders are compared with patients with other substance use disorders, both similarities and differences become apparent and have implications for treatment.

  10. On Dependability of Computing Systems

    Institute of Scientific and Technical Information of China (English)

    XU Shiyi

    1999-01-01

    With the rapid development and wideapplications of computing systems on which more reliance has been put, adependable system will be much more important than ever. This paper isfirst aimed at giving informal but precise definitions characterizingthe various attributes of dependability of computing systems and thenthe importance of (and the relationships among) all the attributes areexplained.Dependability is first introduced as a global concept which subsumes theusual attributes of reliability, availability, maintainability, safetyand security. The basic definitions given here are then commended andsupplemented by detailed material and additional explanations in thesubsequent sections.The presentation has been structured as follows so as to attract thereader's attention to the important attributions of dependability.* Search for a few number of concise concepts enabling thedependability attributes to be expressed as clearly as possible.* Use of terms which are identical or as close as possible tothose commonly used nowadays.This paper is also intended to provoke people's interest in designing adependable computing system.

  11. Glucose-dependent insulinotropic polypeptide

    DEFF Research Database (Denmark)

    Christensen, Mikkel Bring

    2016-01-01

    The hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are secreted by enteroendocrine cells in the intestinal mucosa in response to nutrient ingestion. They are called incretin hormones because of their ability to enhance insulin secretion. However...... the blood glucose levels. In Study 3, we also used stable glucose isotopes to estimate the endogenous glucose production and assessed symptoms and cognitive function during hypoglycaemia. The results from the three studies indicate that GIP has effects on insulin and glucagon responses highly dependent upon...... glucose to prevent hypoglycaemia. In conclusion, the studies position GIP as a bifunctional blood glucose stabilising hormone that glucose-dependently regulates insulin and glucagon responses in humans....

  12. Dependence logic theory and applications

    CERN Document Server

    Kontinen, Juha; Väänänen, Jouko; Vollmer, Heribert

    2016-01-01

    In this volume, different aspects of logics for dependence and independence are discussed, including both the logical and computational aspects of dependence logic, and also applications in a number of areas, such as statistics, social choice theory, databases, and computer security. The contributing authors represent leading experts in this relatively new field, each of whom was invited to write a chapter based on talks given at seminars held at the Schloss Dagstuhl Leibniz Center for Informatics in Wadern, Germany (in February 2013 and June 2015) and an Academy Colloquium at the Royal Netherlands Academy of Arts and Sciences (March 2014). Altogether, these chapters provide the most up-to-date look at this developing and highly interdisciplinary field and will be of interest to a broad group of logicians, mathematicians, statisticians, philosophers, and scientists. Topics covered include a comprehensive survey of many propositional, modal, and first-order variants of dependence logic; new results concerning ...

  13. Automated Test Case Generation

    CERN Document Server

    CERN. Geneva

    2015-01-01

    I would like to present the concept of automated test case generation. I work on it as part of my PhD and I think it would be interesting also for other people. It is also the topic of a workshop paper that I am introducing in Paris. (abstract below) Please note that the talk itself would be more general and not about the specifics of my PhD, but about the broad field of Automated Test Case Generation. I would introduce the main approaches (combinatorial testing, symbolic execution, adaptive random testing) and their advantages and problems. (oracle problem, combinatorial explosion, ...) Abstract of the paper: Over the last decade code-based test case generation techniques such as combinatorial testing or dynamic symbolic execution have seen growing research popularity. Most algorithms and tool implementations are based on finding assignments for input parameter values in order to maximise the execution branch coverage. Only few of them consider dependencies from outside the Code Under Test’s scope such...

  14. Epidemiology, radiology, and genetics of nicotine dependence in COPD

    Directory of Open Access Journals (Sweden)

    Hokanson John E

    2011-01-01

    Full Text Available Abstract Background Cigarette smoking is the principal environmental risk factor for developing COPD, and nicotine dependence strongly influences smoking behavior. This study was performed to elucidate the relationship between nicotine dependence, genetic susceptibility to nicotine dependence, and volumetric CT findings in smokers. Methods Current smokers with COPD (GOLD stage ≥ 2 or normal spirometry were analyzed from the COPDGene Study, a prospective observational study. Nicotine dependence was determined by the Fagerstrom test for nicotine dependence (FTND. Volumetric CT acquisitions measuring the percent of emphysema on inspiratory CT (% of lung Results Among 842 currently smoking subjects (335 COPD cases and 507 controls, 329 subjects (39.1% showed high nicotine dependence. Subjects with high nicotine dependence had greater cumulative and current amounts of smoking. However, emphysema severity was negatively correlated with the FTND score in controls (ρ = -0.19, p Conclusions Nicotine dependence was a negative predictor for emphysema on CT in COPD and control smokers. Increased inflammation in more highly addicted current smokers could influence the CT lung density distribution, which may influence genetic association studies of emphysema phenotypes. Trial registration ClinicalTrials (NCT: NCT00608764

  15. Microalbuminuria in insulin-dependent diabetes

    DEFF Research Database (Denmark)

    Niazy, S; Feldt-Rasmussen, B; Deckert, T

    1987-01-01

    Urinary albumin excretion in a representative sample of 679 patients with Type I (insulin-dependent) diabetes, 18 to 50 years of age, was investigated. Patients on antihypertensive therapy were excluded. Urinary albumin excretion was examined in one 24 hour urine sample using an ELISA technique....... Twenty-three per cent of the patients had microalbuminuria, i.e., 30-300 mg albumin/24 h. The prevalence of microalbuminuria was independent of sex, age, insulin dose and diabetes duration. In the majority of those cases in which microalbuminuria was found during the first 10 years of diabetes......, the concentrations were in the lower range, i.e., 30-50 mg/24 h. The prevalence of incipient nephropathy (urinary albumin excretion in a single urine sample of 51-300 mg/24 h) increased with diabetes duration. In patients with incipient nephropathy hemoglobin A1c tended to be, and blood pressure was, elevated...

  16. Substance dependency among homeless American Indians.

    Science.gov (United States)

    Lobo, Susan; Vaughan, Margaret Mortensen

    2003-01-01

    Extensive qualitative research in the San Francisco Bay Area in California and in Tucson, Arizona, indicates strong associations between substance abuse and homelessness among American Indians. This article takes a comparative approach to describe and analyze precipitating factors and survival patterns of those who are both homeless and who suffer from substance dependency. Possible precipitating factors presented through case studies consider the complex interaction of childhood fostering or adoption into non-Native families, different types of involuntary institutionalization during youth, and the personal impact of accident, trauma and loss. Coping strategies and keys to survival are examined, including the role of the extended family and close friendships, American Indian and mainstream organizations that offer formal and informal services, the existence of anchor or key households, the helping relationships and sobriety groups among homeless individuals, spirituality, and cultural resiliency.

  17. Constitutive model with time-dependent deformations

    DEFF Research Database (Denmark)

    Krogsbøll, Anette

    1998-01-01

    are common in time as well as size. This problem is adressed by means of a new constitutive model for soils. It is able to describe the behavior of soils at different deformation rates. The model defines time-dependent and stress-related deformations separately. They are related to each other and they occur......In many geological and Engineering problems it is necessary to transform information from one scale to another. Data collected at laboratory scale are often used to evaluate field problems on a much larger scale. This is certainly true for geological problems where extreme scale differences...... simultanelously. The model is based on concepts from elasticity and viscoplasticity theories. In addition to Hooke's law for the elastic behavior, the framework for the viscoplastic behavior consists, in the general case (two-dimensional or three-dimensional), of a yield surface, an associated flow rule...

  18. Discrete time queues with phase dependent arrivals

    Science.gov (United States)

    Daigle, J. N.; Lee, Y.; Magalhaes, M. N.

    1994-02-01

    The queueing behavior of many communication systems is well modeled by a queueing system in which time is slotted, and the number of entities that arrive during a slot is dependent upon the state of a discrete time, discrete state Markov chain. Techniques for analyzing such systems have appeared in the literature from time to time, but distributions have been presented in only rare instances. In this paper, we present the probability generating function (PGF) for joint and marginal buffer occupancy distributions of statistical time division multiplexing systems in this class. We discuss inversion of the PGF using discrete Fourier transforms, and also discuss a simple technique for obtaining moments of the queue length distribution. Numerical results, including queue length distributions for some special cases, are presented.

  19. Developing Tests of Visual Dependency

    Science.gov (United States)

    Kindrat, Alexandra N.

    2011-01-01

    Astronauts develop neural adaptive responses to microgravity during space flight. Consequently these adaptive responses cause maladaptive disturbances in balance and gait function when astronauts return to Earth and are re-exposed to gravity. Current research in the Neuroscience Laboratories at NASA-JSC is focused on understanding how exposure to space flight produces post-flight disturbances in balance and gait control and developing training programs designed to facilitate the rapid recovery of functional mobility after space flight. In concert with these disturbances, astronauts also often report an increase in their visual dependency during space flight. To better understand this phenomenon, studies were conducted with specially designed training programs focusing on visual dependency with the aim to understand and enhance subjects ability to rapidly adapt to novel sensory situations. The Rod and Frame test (RFT) was used first to assess an individual s visual dependency, using a variety of testing techniques. Once assessed, subjects were asked to perform two novel tasks under transformation (both the Pegboard and Cube Construction tasks). Results indicate that head position cues and initial visual test conditions had no effect on an individual s visual dependency scores. Subjects were also able to adapt to the manual tasks after several trials. Individual visual dependency correlated with ability to adapt manual to a novel visual distortion only for the cube task. Subjects with higher visual dependency showed decreased ability to adapt to this task. Ultimately, it was revealed that the RFT may serve as an effective prediction tool to produce individualized adaptability training prescriptions that target the specific sensory profile of each crewmember.

  20. Amplitude dependent closest tune approach

    CERN Document Server

    Tomas Garcia, Rogelio; Franchi, Andrea; Maclean, Ewen Hamish; CERN. Geneva. ATS Department

    2016-01-01

    Recent observations in the LHC point to the existence of an amplitude dependent closest tune approach. However this dynamical behavior and its underlying mechanism remain unknown. This effect is highly relevant for the LHC as an unexpectedly closest tune approach varying with amplitude modifies the frequency content of the beam and, hence, the Landau damping. Furthermore the single particle stability would also be affected by this effect as it would modify how particles with varying amplitudes approach and cross resonances. We present analytic derivations that lead to a mechanism generating an amplitude dependent closest tune approach.

  1. Time-Dependent Lagrangian Biomechanics

    OpenAIRE

    Ivancevic, Tijana T.

    2009-01-01

    In this paper we present the time-dependent generalization of an 'ordinary' autonomous human musculo-skeletal biomechanics. We start with the configuration manifold of human body, given as a set of its all active degrees of freedom (DOF). This is a Riemannian manifold with a material metric tensor given by the total mass-inertia matrix of the human body segments. This is the base manifold for standard autonomous biomechanics. To make its time-dependent generalization, we need to extend it wit...

  2. Models for dependent time series

    CERN Document Server

    Tunnicliffe Wilson, Granville; Haywood, John

    2015-01-01

    Models for Dependent Time Series addresses the issues that arise and the methodology that can be applied when the dependence between time series is described and modeled. Whether you work in the economic, physical, or life sciences, the book shows you how to draw meaningful, applicable, and statistically valid conclusions from multivariate (or vector) time series data.The first four chapters discuss the two main pillars of the subject that have been developed over the last 60 years: vector autoregressive modeling and multivariate spectral analysis. These chapters provide the foundational mater

  3. Waveform-dependent absorbing metasurfaces

    CERN Document Server

    Wakatsuchi, Hiroki; Rushton, Jeremiah J; Sievenpiper, Daniel F

    2014-01-01

    We present the first use of a waveform-dependent absorbing metasurface for high-power pulsed surface currents. The new type of nonlinear metasurface, composed of circuit elements including diodes, is capable of storing high power pulse energy to dissipate it between pulses, while allowing propagation of small signals. Interestingly, the absorbing performance varies for high power pulses but not for high power continuous waves (CWs), since the capacitors used are fully charged up. Thus, the waveform dependence enables us to distinguish various signal types (i.e. CW or pulse) even at the same frequency, which potentially creates new kinds of microwave technologies and applications.

  4. [Dependence on benzodiazepines. Clinical and biological aspects].

    Science.gov (United States)

    Pelissolo, A; Bisserbe, J C

    1994-01-01

    The high rate of benzodiazepines (BZD) consumption has been repeatedly confirmed by epidemiological surveys in most major western world countries. In a recent french survey 7% of chronic users of BZD (use in 5/7 days for the last 12 months) were found the general population (17% in the population aged above 65). It has been suggested that the high BZD consumption rate could be related to dependence. The existence of BZD dependence was described in the early sixties with very high dose of chlordiazepoxide but it has become a real concern for the medical community since the late seventies with increasing number of reports of withdrawal symptoms. The extend of the actual rate of withdrawal symptoms at BZD tapering is still very controversial and according to the different studies it varies from 39 to 90%. The between studies difference in parameters such as: the patient populations (psychopathology, treatment duration), the type of tapering employed (duration, nature of the medical and psychological support) and the used operational criteria for withdrawal definition most likely explain this wide variation in the rate of occurrence of withdrawal manifestations. According to the American Psychiatric Association Task Force on Benzodiazepine Dependence, Toxicity and Abuse three type of pathological events can happen after treatment discontinuation: rebound, withdrawal syndrome and recurrence. The rebound consists in the early and transitory reappearance of the anxiety symptoms pre-existing to the treatment but in an exacerbated from; the withdrawal syndrome associates the resurgence of the pre-existing anxiety symptoms and new symptoms as sensory disturbances (metallic taste, hyperosmia, cutaneous exacerbated sensitivity, photophobia...) nausea, headache, motor disturbance in some rare cases depersonalization, paranoid reaction, confusion, convulsion. Rebound or withdrawal syndrome appearance delay varies from hours to few days according mostly to compounds elimination

  5. Dermatology case

    Directory of Open Access Journals (Sweden)

    Susana Vilaça

    2016-02-01

    Full Text Available Tinea corporis is a dermatophyte infection of the body. It usually begins as a pruritic circular or oval erythematous scaling patch or plaque that spreads centrifugally. Multiple lesions may run together to produce “flower petal” configurations. Tinea corporis contracted from infected animals is often intensely inflammatory. The history and clinical picture combination is characteristic, but the diagnosis could be confirmed by KOH (potassium hydroxide examination of scrapings from the lesions. Tinea corporis usually responds to the daily application of topical antifungals, but systemic therapy is needed in patients who have failed topical therapy. We report a case of a two -year old girl with tinea corporis of the vulvar region, initially misdiagnosed as irritant diaper dermatitis.

  6. Solvent dependent photophysical properties of dimethoxy curcumin

    Science.gov (United States)

    Barik, Atanu; Indira Priyadarsini, K.

    2013-03-01

    Dimethoxy curcumin (DMC) is a methylated derivative of curcumin. In order to know the effect of ring substitution on photophysical properties of curcumin, steady state absorption and fluorescence spectra of DMC were recorded in organic solvents with different polarity and compared with those of curcumin. The absorption and fluorescence spectra of DMC, like curcumin, are strongly dependent on solvent polarity and the maxima of DMC showed red shift with increase in solvent polarity function (Δf), but the above effect is prominently observed in case of fluorescence maxima. From the dependence of Stokes' shift on solvent polarity function the difference between the excited state and ground state dipole moment was estimated as 4.9 D. Fluorescence quantum yield (ϕf) and fluorescence lifetime (τf) of DMC were also measured in different solvents at room temperature. The results indicated that with increasing solvent polarity, ϕf increased linearly, which has been accounted for the decrease in non-radiative rate by intersystem crossing (ISC) processes.

  7. Pyridoxine-dependent seizures: a review.

    Science.gov (United States)

    Rajesh, R; Girija, A S

    2003-07-01

    Pyridoxine-dependent seizure is a rare autosomal recessive disorder that usually presents with neonatal intractable seizures. This syndrome results from an inborn abnormality of the enzyme glutamic acid decarboxylase, which results in reduced pyridazine-dependent synthesis of the inhibitory neurotransmitter gamma amino butyric acid. The full range of symptomatology is unknown; but can be associated with autism, breath holding and severe mental retardation, bilious vomiting, transient visual agnosia, severe articulatory apraxia motor dyspraxia, microcephaly and intrauterine seizures. Parenteral pyridine injection test is a highly effective and reproducible test in confirming the diagnosis. Pyridoxine should be administered as a diagnostic test in all cases of convulsive disorders of infancy in which no other diagnosis is evident. Epileptic seizure discharges subside within 2-6 minutes after the intravenous injection of 50-100 mg of pyridaoxine. Once the diagnosis is confirmed, maintenance therapy should be continued indefinitely and doses increased with age or intercurrent illnesses. The maintenance dose of Bg needed is still not clear. There is a relatively wide range for the daily B6 dose necessary to control the seizure i.e., 10-200 mg/day.

  8. Epistemic dependence in interdisciplinary groups

    DEFF Research Database (Denmark)

    Andersen, Hanne; Wagenknecht, Susann

    2013-01-01

    ignores the issue of differences in background knowledge, or it focuses explicitly on conflicting background knowledge. In this paper we provide an analysis of the interplay between epistemic dependence between individual experts with different areas of expertise. We analyze the cooperative activity...

  9. Directional Dependence in Developmental Research

    Science.gov (United States)

    von Eye, Alexander; DeShon, Richard P.

    2012-01-01

    In this article, we discuss and propose methods that may be of use to determine direction of dependence in non-normally distributed variables. First, it is shown that standard regression analysis is unable to distinguish between explanatory and response variables. Then, skewness and kurtosis are discussed as tools to assess deviation from…

  10. Glucose-dependent Insulinotropic Polypeptide

    DEFF Research Database (Denmark)

    Christensen, Mikkel B; Calanna, Salvatore; Holst, Jens Juul

    2014-01-01

    CONTEXT: Patients with type 2 diabetes mellitus (T2DM) have clinically relevant disturbances in the effects of the hormone glucose-dependent insulinotropic polypeptide (GIP). OBJECTIVE: We aimed to evaluate the importance of the prevailing plasma glucose levels for the effect of GIP on responses...

  11. Network-timing-dependent plasticity

    Directory of Open Access Journals (Sweden)

    Vincent eDelattre

    2015-06-01

    Full Text Available Bursts of activity in networks of neurons are thought to convey salient information and drive synaptic plasticity. Here we report that network bursts also exert a profound effect on Spike-Timing-Dependent Plasticity (STDP. In acute slices of juvenile rat somatosensory cortex we paired a network burst, which alone induced long-term depression (LTD, with STDP-induced long-term potentiation and depression (LTP and LTD. We observed that STDP-induced LTP was either unaffected, blocked or flipped into LTD by the network burst, and that STDP-induced LTD was either saturated or flipped into LTP, depending on the relative timing of the network burst with respect to spike coincidences of the STDP event. We hypothesized that network bursts flip STDP-induced LTP to LTD by depleting resources needed for LTP and therefore developed a resource-dependent STDP learning rule. In a model neural network under the influence of the proposed resource-dependent STDP rule, we found that excitatory synaptic coupling was homeostatically regulated to produce power law distributed burst amplitudes reflecting self-organized criticality, a state that ensures optimal information coding.

  12. Network-timing-dependent plasticity.

    Science.gov (United States)

    Delattre, Vincent; Keller, Daniel; Perich, Matthew; Markram, Henry; Muller, Eilif B

    2015-01-01

    Bursts of activity in networks of neurons are thought to convey salient information and drive synaptic plasticity. Here we report that network bursts also exert a profound effect on Spike-Timing-Dependent Plasticity (STDP). In acute slices of juvenile rat somatosensory cortex we paired a network burst, which alone induced long-term depression (LTD), with STDP-induced long-term potentiation (LTP) and LTD. We observed that STDP-induced LTP was either unaffected, blocked or flipped into LTD by the network burst, and that STDP-induced LTD was either saturated or flipped into LTP, depending on the relative timing of the network burst with respect to spike coincidences of the STDP event. We hypothesized that network bursts flip STDP-induced LTP to LTD by depleting resources needed for LTP and therefore developed a resource-dependent STDP learning rule. In a model neural network under the influence of the proposed resource-dependent STDP rule, we found that excitatory synaptic coupling was homeostatically regulated to produce power law distributed burst amplitudes reflecting self-organized criticality, a state that ensures optimal information coding.

  13. Temperature dependence of surface nanobubbles

    NARCIS (Netherlands)

    Berkelaar, R.P.; Seddon, James Richard Thorley; Zandvliet, Henricus J.W.; Lohse, Detlef

    2012-01-01

    The temperature dependence of nanobubbles was investigated experimentally using atomic force microscopy. By scanning the same area of the surface at temperatures from 51 °C to 25 °C it was possible to track geometrical changes of individual nanobubbles as the temperature was decreased.

  14. Spin dependent proton structure functions

    Energy Technology Data Exchange (ETDEWEB)

    de Florian, D.; Garcia Canal, C.A. [Laboratorio de Fisica Teorica, Departamento de Fisica, Universidad Nacional de La Plata C.C. 67-1900 La Plata (Argentina); Sassot, R. [Departamento de Fisica, Universidad de Buenos Aires, Ciudad Universitaria, Pab. 1 1428 Bs.As. (Argentina)

    1996-02-01

    We address the issue of gluon contributions to the polarized deep inelastic asymmetries. Particularly, of their effects in the scale dependence induced by the usual leading order Altarelli-Parisi evolution equations and those arising from fixed order {alpha}{sub {ital s}} and {alpha}{sup 2}{sub {ital s}} evolution approximations. {copyright} {ital 1996 American Institute of Physics.}

  15. Markov sequential pattern recognition : dependency and the unknown class.

    Energy Technology Data Exchange (ETDEWEB)

    Malone, Kevin Thomas; Haschke, Greg Benjamin; Koch, Mark William

    2004-10-01

    The sequential probability ratio test (SPRT) minimizes the expected number of observations to a decision and can solve problems in sequential pattern recognition. Some problems have dependencies between the observations, and Markov chains can model dependencies where the state occupancy probability is geometric. For a non-geometric process we show how to use the effective amount of independent information to modify the decision process, so that we can account for the remaining dependencies. Along with dependencies between observations, a successful system needs to handle the unknown class in unconstrained environments. For example, in an acoustic pattern recognition problem any sound source not belonging to the target set is in the unknown class. We show how to incorporate goodness of fit (GOF) classifiers into the Markov SPRT, and determine the worse case nontarget model. We also develop a multiclass Markov SPRT using the GOF concept.

  16. Time dependent friction in a free gas

    Science.gov (United States)

    Fanelli, Cristiano; Sisti, Francesco; Stagno, Gabriele V.

    2016-03-01

    We consider a body moving in a perfect gas, described by the mean-field approximation and interacting elastically with the body, we study the friction exerted by the gas on the body fixed at constant velocities. The time evolution of the body in this setting was studied in Caprino et al. [Math. Phys. 264, 167-189 (2006)], Caprino et al. [Math. Models Methods Appl. Sci. 17, 1369-1403 (2007)], and Cavallaro [Rend. Mat. Appl. 27, 123-145 (2007)] for object with simple shape; the first study where a simple kind of concavity was considered was in Sisti and Ricciuti [SIAM J. Math. Anal. 46, 3759-3611 (2014)], showing new features in the dynamic but not in the friction term. The case of more general shape of the body was left out for further difficulties, and we believe indeed that there are actually non-trivial issues to be faced for these more general cases. To show this and in the spirit of getting a more realistic perspective in the study of friction problems, in this paper, we focused our attention on the friction term itself, studying its behavior on a body with a more general kind of concavity and fixed at constant velocities. We derive the expression of the friction term for constant velocities, we show how it is time dependent, and we give its exact estimate in time. Finally, we use this result to show the absence of a constant velocity in the actual dynamic of such a body.

  17. Case Study: Testing with Case Studies

    Science.gov (United States)

    Herreid, Clyde Freeman

    2015-01-01

    This column provides original articles on innovations in case study teaching, assessment of the method, as well as case studies with teaching notes. This month's issue discusses using case studies to test for knowledge or lessons learned.

  18. Case Study: Testing with Case Studies

    Science.gov (United States)

    Herreid, Clyde Freeman

    2015-01-01

    This column provides original articles on innovations in case study teaching, assessment of the method, as well as case studies with teaching notes. This month's issue discusses using case studies to test for knowledge or lessons learned.

  19. Effects of Different Time-Dependent Couplings on Two-Atom Entanglement

    Institute of Scientific and Technical Information of China (English)

    ZHOU Ling; GAO Wen-Bin; YANG Guo-Hui; SONG He-Shan

    2007-01-01

    The effects of different time-independent and time-dependent couplings on two-atom entanglement are studied. The results show that the effects depend on the initial state. For the initial state |ee0>, it is found that different time-independent couplings make the case without entanglement exhibit entanglement, and time-dependent couplings turn the irregular entanglement regions into regular one. Under the case of decay, for the initial state |eg0>, the different time-dependent couplings have disbenefit.

  20. Characteristics of methylphenidate dependence syndrome in psychiatric hospital settings.

    Science.gov (United States)

    Ozaki, Shigeru; Wada, Kiyoshi

    2006-04-01

    The characteristics of methylphenidate (MPD) cases reported in a nationwide mental hospital survey on substance-related psychiatric disorders are studied compared to methamphetamine cases. Although the two groups did not differ in terms of age and sex, the MPD group revealed longer educational histories and lower antisocial traits. About half of the MPD group had a history of methamphetamine use and 30% had used the substance as the initial substance of abuse. They exhibited a general tendency toward multiple substance use. These results indicate that a significant number of MPD cases exist who used MPD as a substance alternative to methamphetamine and also suggest that they may potentially have a tendency to develop abuse or dependence. The MPD cases most likely had a psychiatric diagnosis of "Dependence syndrome (F15.2)," according to the ICD-10 guidelines. The SDS scores also indicated a more severe dependence syndrome, particularly psychological dependence, which they may possibly develop more quickly. An abundance of information for MPD abusers to utilize is available through the internet, including the pharmacological properties, such as increased sensation or elation through MPD intake and how and where to easily acquire the substance. They may even forge a prescription to obtain MPD. This behavior can be recognized as "substance-seeking behavior" in behavioral pharmacology terms, accompanied by craving based on psychological dependence on the substance, and can be very difficult to control. Little evidence exists regarding the effectiveness and necessity of MPD as a treatment for depression, and thus MPD prescriptions must be carefully considered by psychiatrists or physicians. The application of MPD as an antidepressant in the health insurance system must be re-examined as well.