WorldWideScience

Sample records for nonoffenders late onsetters

  1. Exploring Nonoffending Caregiver Satisfaction with a Children's Advocacy Center

    Science.gov (United States)

    Bonach, Kathryn; Mabry, J. Beth; Potts-Henry, Candice

    2010-01-01

    This study is a case evaluation research report on one Children's Advocacy Center that provides a coordinated response to allegations of child maltreatment, particularly sexual abuse. The data come from a mailed survey of nonoffending caregivers measuring their satisfaction with services provided through the Children's Advocacy Center. The results…

  2. Suppression of aggressive rorschach responses among violent offenders and nonoffenders.

    Science.gov (United States)

    Benjestorf, Sue TaVoularis; Viglione, Donald J; Lamb, Judy D; Giromini, Luciano

    2013-10-01

    This Rorschach study explored the suppression of aggression content when violent offenders and nonoffenders are asked to present themselves as not posing a threat of dangerousness in a court role-playing context. Aggressive content and complexity in this suppressive role-play context was compared to a neutral control condition. A total of 41 participants, approximately half violent offenders and half nonoffenders took the Rorschach under both conditions. Results indicate that both groups suppressed aggression content on the Rorschach without altering response complexity. This large effect size for testing condition may partly explain the inconsistencies across previous studies. It is possible that violent offenders have typically been tested in highly suppressive conditions whereas nonoffender or normative groups may have been tested in relatively low suppression conditions. If so, aggression score differences may be a reflection of the testing condition, not group differences. Both instructional sets produced similar levels of complexity, so that individuals do not simplify responses when they screen out aggressive attributions. Violent offenders did not differ from nonviolent offenders in terms of aggression content, but did produce more simplistic records. In addition, this study also undertook a semantic, textual analysis and found that individuals in the suppressive condition tended to eliminate many response elaborations, particularly those with negative of threatening connotations.

  3. "The Effects of Mixing Offenders with Non-Offenders: Findings from a Danish Quasi Experiment"

    DEFF Research Database (Denmark)

    Kjær Minke, Linda

    2011-01-01

    This study examines the effects of mixing offenders with nonoffenders at Skejby half-way house in Denmark. Skejby halfway house constitutes an outstanding social experiment, as offenders are deliberately mixed with non-offenders in order to reduce their risk of recidivism. The treatment group...

  4. Second-to-fourth digit ratio and impulsivity: a comparison between offenders and nonoffenders.

    Directory of Open Access Journals (Sweden)

    Yaniv Hanoch

    Full Text Available Personality characteristics, particularly impulsive tendencies, have long been conceived as the primary culprit in delinquent behavior. One crucial question to emerge from this line of work is whether impulsivity has a biological basis. To test this possibility, 44 male offenders and 46 nonoffenders completed the Eysenck Impulsivity Questionnaire, and had their 2D∶4D ratio measured. Offenders exhibited smaller right hand digit ratio measurements compared to non-offenders, but higher impulsivity scores. Both impulsivity and 2D∶4D ratio measurements significantly predicted criminality (offenders vs. nonoffenders. Controlling for education level, the 2D∶4D ratio measurements had remained a significant predictor of criminality, while impulsivity scores no longer predicted criminality significantly. Our data, thus, indicates that impulsivity but not 2D∶4D ratio measurements relate to educational attainment. As offenders varied in their number of previous convictions and the nature of their individual crimes, we also tested for differences in 2D∶4D ratio and impulsivity among offenders. Number of previous convictions did not correlate significantly with the 2D∶4D ratio measurements or impulsivity scores. Our study established a link between a biological marker and impulsivity among offenders (and lack thereof among non-offenders, which emphasise the importance of studying the relationship between biological markers, impulsivity and criminal behavior.

  5. Nonoffending Parent Expectations of Sexually Abused Children: Predictive Factors and Influence on Children's Recovery

    Science.gov (United States)

    Kouyoumdjian, Haig; Perry, Andrea R.; Hansen, David J.

    2009-01-01

    This study examined the influence of parental expectations on the functioning of sexually abused children. Participants included 67 sexually abused youth and 63 of their nonoffending primary caregivers. Parental expectations about how sexual abuse will impact children were predictive of parents' ratings of children's behavior at pretreatment,…

  6. Second-to-fourth digit ratio and impulsivity: a comparison between offenders and nonoffenders.

    Science.gov (United States)

    Hanoch, Yaniv; Gummerum, Michaela; Rolison, Jonathan

    2012-01-01

    Personality characteristics, particularly impulsive tendencies, have long been conceived as the primary culprit in delinquent behavior. One crucial question to emerge from this line of work is whether impulsivity has a biological basis. To test this possibility, 44 male offenders and 46 nonoffenders completed the Eysenck Impulsivity Questionnaire, and had their 2D∶4D ratio measured. Offenders exhibited smaller right hand digit ratio measurements compared to non-offenders, but higher impulsivity scores. Both impulsivity and 2D∶4D ratio measurements significantly predicted criminality (offenders vs. nonoffenders). Controlling for education level, the 2D∶4D ratio measurements had remained a significant predictor of criminality, while impulsivity scores no longer predicted criminality significantly. Our data, thus, indicates that impulsivity but not 2D∶4D ratio measurements relate to educational attainment. As offenders varied in their number of previous convictions and the nature of their individual crimes, we also tested for differences in 2D∶4D ratio and impulsivity among offenders. Number of previous convictions did not correlate significantly with the 2D∶4D ratio measurements or impulsivity scores. Our study established a link between a biological marker and impulsivity among offenders (and lack thereof among non-offenders), which emphasise the importance of studying the relationship between biological markers, impulsivity and criminal behavior.

  7. A Comparison of Anger in Offenders and Non-Offenders Who Have Intellectual Disabilities

    Science.gov (United States)

    Nicoll, Matthew; Beail, Nigel

    2013-01-01

    Background: There is growing evidence of the effectiveness of cognitive behavioural therapy to treat anger in offenders with intellectual disabilities. The aim is to lower anger levels; the rationale is that this will reduce recidivism. However, the hypothesis that anger levels amongst offenders are higher than non-offenders has not been tested.…

  8. Nonoffending Parent Expectations of Sexually Abused Children: Predictive Factors and Influence on Children's Recovery

    Science.gov (United States)

    Kouyoumdjian, Haig; Perry, Andrea R.; Hansen, David J.

    2009-01-01

    This study examined the influence of parental expectations on the functioning of sexually abused children. Participants included 67 sexually abused youth and 63 of their nonoffending primary caregivers. Parental expectations about how sexual abuse will impact children were predictive of parents' ratings of children's behavior at pretreatment,…

  9. Social Service Professionals' Perceptions of Nonoffending Caregivers in Child Sexual Abuse Cases

    Science.gov (United States)

    Wolfteich, Paula M.; Cline, Monica L.

    2013-01-01

    This study was designed to assess social service workers' perceptions of nonoffending caregivers in cases of child sexual abuse. Attributions of blame were examined by administering questionnaires to staff at local social service agencies. It was hypothesized that social service workers who worked in the field longer, were male, or had less…

  10. Reinforcement sensitivity of sex offenders and non-offenders: an experimental and psychometric study of reinforcement sensitivity theory.

    Science.gov (United States)

    Leue, Anja; Brocke, Burkhard; Hoyer, Jürgen

    2008-08-01

    This study tested predictions of Gray's Reinforcement Sensitivity Theory (RST) in subgroups of sex offenders and male non-offenders using an experimental choice task consisting of a reward and a non-reward phase. In addition, RST-related psychometric measures were used. Both experimental and psychometric data were of interest to determine whether sex offenders could be reliably differentiated from non-offenders. Paraphilic (N=50) and impulse control-disordered (N=48) sex offenders showed greater sensitivity to continuous reward than male non-offenders (N=51). Impulse control-disordered sex offenders showed less behavioural adaptation under non-reward than both paraphilic sex offenders and male non-offenders. In addition, reward sensitivity, rash-spontaneous impulsivity, and anxiety measures discriminated sex offenders from male non-offenders. The results suggest that reinforcement sensitivity is a promising personality trait for differentiating subgroups of sex offenders from non-offenders. The experimental and psychometric results illustrate that predictive accuracy in forensic settings could be improved by combining several types of data.

  11. Psychological and Physical Health of Nonoffending Parents After Disclosure of Sexual Abuse of Their Child.

    Science.gov (United States)

    Cyr, Mireille; Frappier, Jean-Yves; Hébert, Martine; Tourigny, Marc; McDuff, Pierre; Turcotte, Marie-Ève

    2016-10-01

    Disclosure of child sexual abuse can be traumatic for nonoffending parents. Research has shown its impact on mothers' mental health, which includes heightened psychological distress, depression, and post-traumatic stress disorder. Very little is known, however, about its impact on their physical health or on fathers' health. The self-perceived mental and physical health of nonoffending parents after child sexual abuse disclosure was compared to determine gender-related differences in this regard. Interviews were conducted with 109 mothers and 43 fathers of 6- to 13-year-old sexually abused children. Bivariate analyses revealed that a fair proportion of parents reported psychological and physical problems after disclosure. However, proportionally more mothers than fathers reported psychological distress, depression, and use of professional services. Fathers were more likely to resort to health services instead of social services and to use medication for depression. Study findings provide leads for health and social service providers for the development of intervention protocols and referral procedures sensitive to gender issues, and they shed new light on specific needs of nonoffending parents.

  12. Structured Therapeutic Games for Nonoffending Caregivers of Children Who Have Experienced Sexual Abuse.

    Science.gov (United States)

    Springer, Craig I; Colorado, Giselle; Misurell, Justin R

    2015-01-01

    Game-based cognitive-behavioral therapy group model for nonoffending caregivers utilizes structured therapeutic games to assist parents following child sexual abuse. Game-based cognitive-behavioral therapy group model is a manualized group treatment approach that integrates evidence-based cognitive-behavioral therapy components with structured play therapy to teach parenting and coping skills, provide psychoeducation, and process trauma. Structured therapeutic games were designed to allow nonoffending caregivers to process their children's abuse experiences and learn skills necessary to overcome trauma in a nonthreatening, fun, and engaging manner. The implementation of these techniques allow clinicians to address a variety of psychosocial difficulties that are commonly found among nonoffending caregivers of children who have experienced sexual abuse. In addition, structured therapeutic games help caregivers develop strengths and abilities that they can use to help their children cope with abuse and trauma and facilitates the development of positive posttraumatic growth. Techniques and procedures for treatment delivery along with a description of core components and therapeutic modules are discussed. An illustrative case study is provided.

  13. Psychopathic traits in young offenders vs. non-offenders in similar socioeconomic condition

    Directory of Open Access Journals (Sweden)

    Gustavo B. Castellana

    2014-09-01

    Full Text Available Objective: To analyze the differences in psychopathic traits between offender and non-offender youths with similar socioeconomic backgrounds. Method: The Psychopathy Checklist Revised (PCL-R scale was used to identify whether 39 young offenders with no history of mental disorders or criteria for psychopathy exhibited differences in its total score, and specifically for factor 1 or factor 2 of this scale, when compared with 32 other young people, living in similar socioeconomic conditions, who had not committed offenses. Results: We observed statistically significant between-group differences (p < 0.01 in mean PCL-R scores, with a mean score of 13.4 in the offender group vs. 2.1 in the non-offender group. We also detected significant between-group differences when we analyzed mean factor 1 (p < 0.01 and factor 2 (p < 0.01 scores separately. Although the groups exhibited statistically significant difference in educational attainment, between-group comparison of mean PCL-R scores controlling for educational attainment by analysis of covariance (ANCOVA showed that the difference in PCL-R scores remained statistically significant (p < 0.01. Conclusions: We conclude that, in this sample, the presence of both primary (interpersonal/affective characteristics and secondary (lifestyle/antisocial behavior psychopathic traits differed between offender and non-offender youths, even when excluding psychopathy and other mental disorders from the assessments. These results suggest a need for wide-ranging interventions, not restricted to socioeconomic aspects, for the management of juvenile delinquency.

  14. UNDERSTANDING CONATIVE REGULATION SYSTEMS – AN EXAMINATION OF THE DIFFERENCES BETWEEN OFFENDERS AND NON-OFFENDERS

    Directory of Open Access Journals (Sweden)

    Sanja DJURDJEVIC

    2016-04-01

    Full Text Available Introduction: Numerous studies confirmed personality traits as being important predictors of criminal behavior. The aim of this research was to determine which constellation of basic personality traits incarcerated individuals and those serving alternative sanctions differ, and which traits make the difference between the criminal and the non-criminal populations. In this research, the model of personality used is a cybernetic model of conative functioning, which assumes that conative regulation systems almost completely describe the structure of personality. Methods: The study sample consisted of 391 male respondents (152 offenders serving prison sentence, 91 convicts sentenced to alternative penalties and 148 non-offenders. Examined variables were: the regulator of activity (Extroversion, the regulator of organic functions (Hysteria, the regulator of defense reactions (Anxiety, the regulator of attack reactions (Aggressiveness, the system for coordination of regulatory functions (Psychoticism and the system for integration of regulatory functions (Integration. Results: There were significant differences in all dimensions of personality between groups, except for the framework of Extraversion. The traits that contribute to the difference between individuals serving prison sentence and offenders sentenced to alternative penalties are Integration and Aggressiveness. The traits that contribute to the difference between non-offenders and offenders serving prison sentence are Psychoticism, Integration, Aggressiveness, and Anxiety. Among offenders sentenced to alternative penalties and the general population no difference in personality traits was found. Conclusion: Our findings may indicate the need for mandatory diagnostic psychological evaluation of persons who have committed minor offenses, to ensure the right decision is made when choosing between prison and an alternative method of punishment.

  15. Evidence for superior neurobiological and behavioral inhibitory control abilities in non-offending as compared to offending pedophiles.

    Science.gov (United States)

    Kärgel, Christian; Massau, Claudia; Weiß, Simone; Walter, Martin; Borchardt, Viola; Krueger, Tillmann H C; Tenbergen, Gilian; Kneer, Jonas; Wittfoth, Matthias; Pohl, Alexander; Gerwinn, Hannah; Ponseti, Jorge; Amelung, Till; Beier, Klaus M; Mohnke, Sebastian; Walter, Henrik; Schiffer, Boris

    2017-02-01

    Neurobehavioral models of pedophilia and child sexual offending suggest a pattern of temporal and in particular prefrontal disturbances leading to inappropriate behavioral control and subsequently an increased propensity to sexually offend against children. However, clear empirical evidence for such mechanisms is still missing. Using a go/nogo paradigm in combination with functional magnetic resonance imaging (fMRI) we compared behavioral performance and neural response patterns among three groups of men matched for age and IQ: pedophiles with (N = 40) and without (N = 37) a history of hands-on sexual offences against children as well as healthy non-offending controls (N = 40). As compared to offending pedophiles, non-offending pedophiles exhibited superior inhibitory control as reflected by significantly lower rate of commission errors. Group-by-condition interaction analysis also revealed inhibition-related activation in the left posterior cingulate and the left superior frontal cortex that distinguished between offending and non-offending pedophiles, while no significant differences were found between pedophiles and healthy controls. Both areas showing distinct activation pattern among pedophiles play a critical role in linking neural networks that relate to effective cognitive functioning. Data therefore suggest that heightened inhibition-related recruitment of these areas as well as decreased amount of commission errors is related to better inhibitory control in pedophiles who successfully avoid committing hands-on sexual offences against children. Hum Brain Mapp 38:1092-1104, 2017. © 2016 Wiley Periodicals, Inc.

  16. The evaluation of violent thinking in adult offenders and non-offenders using the Maudsley Violence Questionnaire.

    Science.gov (United States)

    Walker, Julian; Bowes, Nicola

    2013-04-01

    The Maudsley Violence Questionnaire (MVQ) was designed to measure explicit rules and beliefs associated with violence. Previous studies with young people and offenders with mental disorder found the MVQ to be a valid and reliable measure of violent thinking. This study explores the use of the MVQ with a 'normal' (non-offender) population and an offender population without mental illness in order to evaluate how the MVQ's subscales related to violence within these groups. The MVQ was given to 78 adult male participants along with a measure of self-reported violence; demographic information and criminal history were also recorded. Thirty-five of the participants were convicted adult male offenders resident of an adult male closed prison in South Wales; 43 were volunteers from the staff group in the same prison. The MVQ factors were compared with self-reported violence and with officially recorded violent convictions. Although both subscales of the MVQ related to self-reported violence, 'Machismo' showed a stronger relationship to both self-reported and officially recorded violence. Violent thinking, specifically beliefs measured by the Machismo subscale of the MVQ, was robustly associated with self-reported and officially recorded violence in this study with offender and non-offender adults. The MVQ is a valid and feasible measure for use with adult populations. Violent thinking (specifically Machismo thinking styles) should be included in the assessments of violent offenders. Work on violent thinking and reducing 'macho' thinking could be a useful adjunct to anger management work with violent offenders. Copyright © 2013 John Wiley & Sons, Ltd.

  17. Anger parameters in parolees undergoing psychoeducation: Temporal stability, social desirability bias, and comparison with non-offenders.

    Science.gov (United States)

    Fernandez, Ephrem; Kiageri, Vasiliki; Guharajan, Deepan; Day, Andrew

    2017-09-08

    Anger is commonly measured as if it were a single, simple construct. This may be particularly unhelpful if the main purpose of a measure is to determine change and responsiveness to interventions. Our primary aim was to assess five anger parameters in parolees - frequency, duration, intensity, latency, and threshold - and to test for effects of psychoeducation and social desirability bias on parolees' scores. Average anger scores for the offender sample were compared with those in a non-offender sample. The offender sample was drawn from male parolees in San Antonio. Age-matched volunteers recruited at public libraries were engaged for baseline comparisons. The Anger Parameters Scale and the Marlow-Crowne Scale were used to assess anger and social desirability, respectively. Parole officers delivered a psychoeducation course to parolees over 12 weeks, and anger and social desirability measures were taken before and afterwards. At baseline, parolees were angry more often, stayed angry longer, and reached higher levels of anger than the non-offenders, confirming their eligibility for the programme. Mean anger scores were not significantly different after psychoeducation than before it. Parolees' reported anger was significantly and negatively correlated with social desirability scores. Only three of the five anger parameters were prominent among these offenders: frequency, duration, and intensity of their outbursts. Psychoeducation did not produce improvement, possibly because it was instructional rather than therapeutic, but also because group means may mask useful individual differences. Concurrent assessment of social desirability is likely to assist in interpretation of anger measures. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  18. Parenting Styles, Prosocial, and Aggressive Behavior: The Role of Emotions in Offender and Non-offender Adolescents

    Directory of Open Access Journals (Sweden)

    Anna Llorca

    2017-08-01

    Full Text Available The aim is to analyse the parenting styles effects (acceptance, negative control and negligence on prosociality and aggressive behavior in adolescents through the mediator variables empathy and emotional instability, and also, if this model fits to the same extent when we study adolescents institutionalized due to problems with the law and adolescents from the general population, and at the same time, if the values of the different analyzed variables are similar in both groups of adolescents. We carried out a cross-sectional study. 220 participants from schools in the metropolitan area of Valencia took part in the study. Also, 220 young offenders took part recruited from four Youth Detention Centres of Valencia, in which they were carrying out court sentences. The age of the subjects range from 15-18 years. The results indicate that the emotional variables act as mediators in general, in the non-offender adolescents, but it has been observed, in the offender adolescents, a direct effect of support on aggressive behavior in a negative way and on prosociality in a positive way; and of negligence on aggressive behavior and of permissiveness on prosociality in a negative way.

  19. Relations of Distinct Psychopathic Personality Traits with Anxiety and Fear: Findings from Offenders and Non-Offenders.

    Science.gov (United States)

    Gillespie, Steven M; Mitchell, Ian J; Satherley, Rose-Marie; Beech, Anthony R; Rotshtein, Pia

    2015-01-01

    Early descriptions of psychopathy emphasise fearlessness and a lack of nervousness or anxiety as key characteristics of the disorder. However, conflicting evidence suggests that anxiety may be positively correlated with some aspects of the psychopathy construct. This position may seem somewhat paradoxical when considered alongside impaired processing of fear related stimuli in psychopathic personality. The aim of the current paper was to examine the distinct relations of callous, egocentric, and antisocial psychopathic traits with measures of anxiety and social anxiety in samples of non-offenders (Study 1) and violent offenders (Study 2). In Study 2 we also used an emotion recognition task to examine fearful face recognition. In Studies 1 and 2 we showed distinct and opposite significant relationships of egocentric and antisocial psychopathic traits with trait anxiety. Thus, while trait anxiety was negatively predicted by egocentric traits, it was predicted in a positive direction by antisocial traits in both samples. In Study 2 we found that callous traits were predictive of greater impairments in fearful face recognition. These findings suggest that anxiety and fear are distinguishable constructs in relation to psychopathic personality traits, and are discussed in terms of potentially separable mechanisms for these two constructs.

  20. Psychopathic traits are associated with reduced attention to the eyes of emotional faces among adult male non-offenders

    Directory of Open Access Journals (Sweden)

    Steven Mark Gillespie

    2015-10-01

    Full Text Available Psychopathic traits are linked with impairments in emotional facial expression recognition. These impairments may, in part, reflect reduced attention to the eyes of emotional faces. Although reduced attention to the eyes has been noted among children with conduct problems and callous-unemotional traits, similar findings are yet to be found in relation to psychopathic traits among adult male participants. Here we investigated the relationship of primary (selfish, uncaring and secondary (impulsive, antisocial psychopathic traits with attention to the eyes among adult male non-offenders during an emotion recognition task. We measured the number of fixations, and overall dwell time, on the eyes and the mouth of male and female faces showing the six basic emotions at varying levels of intensity. We found no relationship of primary or secondary psychopathic traits with recognition accuracy. However, primary psychopathic traits were associated with a reduced number of fixations, and lower overall dwell time, on the eyes relative to the mouth across expressions, intensity, and sex. Furthermore, the relationship of primary psychopathic traits with attention to the eyes of angry and fearful faces was influenced by the sex and intensity of the expression. We also showed that a greater number of fixations on the eyes, relative to the mouth, was associated with increased accuracy for angry and fearful expression recognition. These results are the first to show effects of psychopathic traits on attention to the eyes of emotional faces in an adult male sample, and may support amygdala based accounts of psychopathy. These findings may also have methodological implications for clinical studies of emotion recognition.

  1. Late Budgets

    DEFF Research Database (Denmark)

    Andersen, Asger Lau; Lassen, David Dreyer; Nielsen, Lasse Holbøll Westh

    The budget forms the legal basis of government spending. If a budget is not in place at the beginning of the fiscal year, planning as well as current spending are jeopardized and government shutdown may result. This paper develops a continuous-time war-of-attrition model of budgeting...... in a presidential style-democracy to explain the duration of budget negotiations. We build our model around budget baselines as reference points for loss averse negotiators. We derive three testable hypotheses: there are more late budgets, and they are more late, when fiscal circumstances change; when such changes...... are negative rather than positive; and when there is divided government. We test the hypotheses of the model using a unique data set of late budgets for US state governments, based on dates of budget approval collected from news reports and a survey of state budget o¢ cers for the period 1988...

  2. Late Budgets

    DEFF Research Database (Denmark)

    Andersen, Asger Lau; Lassen, David Dreyer; Nielsen, Lasse Holbøll Westh

    are negative rather than positive; and when there is divided government. We test the hypotheses of the model using a unique data set of late budgets for US state governments, based on dates of budget approval collected from news reports and a survey of state budget o¢ cers for the period 1988......The budget forms the legal basis of government spending. If a budget is not in place at the beginning of the fiscal year, planning as well as current spending are jeopardized and government shutdown may result. This paper develops a continuous-time war-of-attrition model of budgeting...... in a presidential style-democracy to explain the duration of budget negotiations. We build our model around budget baselines as reference points for loss averse negotiators. We derive three testable hypotheses: there are more late budgets, and they are more late, when fiscal circumstances change; when such changes...

  3. Exploring Late Globalization

    DEFF Research Database (Denmark)

    Turcan, Romeo V.

    2016-01-01

    The purpose of this viewpoint paper is to motivate a program of research on late globalization, a program that could eventually lead to one or more significant theories of late globalization. The paper explores the phenomenon of late globalization as well as the idea of “late” by drawing on sparse...... literature on late globalization from sociocultural and economic perspectives. It illustrates in a vignette the character and features of late globalization observable in the withdrawal from foreign locations or deinternationalization of universities, as late globalizing entitis. The paper discusses...... the range of constructs around the core idea of late globalization, generating questions for future work in a late globalization research program....

  4. Late Accretion and the Late Veneer

    CERN Document Server

    Morbidelli, Alessandro

    2014-01-01

    The concept of Late Veneer has been introduced by the geochemical community to explain the abundance of highly siderophile elements in the Earth's mantle and their chondritic proportions relative to each other. However, in the complex scenario of Earth accretion, involving both planetesimal bombardment and giant impacts from chondritic and differentiated projectiles, it is not obvious what the "Late Veneer" actually corresponds to. In fact, the process of differentiation of the Earth was probably intermittent and there was presumably no well-defined transition between an earlier phase where all metal sunk into the core and a later phase in which the core was a closed entity separated from the mantle. In addition, the modellers of Earth accretion have introduced the concept of "Late Accretion", which refers to the material accreted by our planet after the Moon-forming event. Characterising Late Veneer, Late Accretion and the relationship between the two is the major goal of this chapter.

  5. Adversidade familiar e problemas comportamentais entre adolescentes infratores e não-infratores Adversidad familiar y problemas de comportamiento entre adolescentes infractores y no-infractores Family adversity and behavior problems among adolescent offenders and non-offenders

    Directory of Open Access Journals (Sweden)

    Maria Delfina Farias Dias Tavares da Silva

    2008-12-01

    infractores y sus padres.Young offenders and non-offenders are compared on two aspects: Family Adversity Index and Agreement Index between parents' perception and adolescents' self-perception on the behavior problem. Participants comprised 40 adolescents, or rather, 23 were being attended to at Attendance and Support Center for Young People (UNIFESP and 17 adolescent offenders at the Court for the Welfare of Children and Young People in Santos SP Brazil. Child Behavior Checklist (CBCL, Youth Self Report (YSR and Rutter's Family Adversity Index were employed. The family adversity index was significantly higher for young offenders. Results show that percentage of disagreement scores between the perceptions of behavior problems was higher, albeit not significant, between adolescent offenders and their parents.

  6. Late recurrence of medulloblastoma.

    Science.gov (United States)

    Stevens, Brittney; Razzaqi, Faisal; Yu, Lolie; Craver, Randall

    2008-01-01

    We present a child with a cerebellar medulloblastoma, diagnosed at age three, treated with near total surgical resection, radiotherapy, and chemotherapy, that recurred 13 years after the initial diagnosis. This late recurrence exceeds the typical 10-year survival statistics that are in common use, and exceeds the Collins rule. Continued follow-up of these children is justified to increase the likelihood of detecting these late recurrences early and to learn more about these late recurrences.

  7. Personality in Late Midlife

    DEFF Research Database (Denmark)

    Mortensen, Erik Lykke; Flensborg-Madsen, Trine; Molbo, Drude

    2014-01-01

    To analyze associations in late midlife between sex, age, education and social class, and the Big Five personality traits; to analyze associations between personality traits and cognitive ability in late midlife; and to evaluate how these associations are influenced by demographic factors....

  8. Late-Stage Caregiving

    Science.gov (United States)

    ... resources, care and ways to engage in meaningful connections. During the late stages, your role as a ... drinks. This will help you track the person's natural routine, and then you can plan a schedule. ...

  9. Suicides in late life.

    Science.gov (United States)

    Van Orden, Kimberly; Conwell, Yeates

    2011-06-01

    Suicide in late life is an enormous public health problem that will likely increase in severity as adults of the baby boom generation age. Data from psychological autopsy studies supplemented with recent studies of suicidal ideation and attempts point to a consistent set of risk factors for the spectrum of suicidal behaviors in late life (suicide ideation, attempts, and deaths). Clinicians should be vigilant for psychiatric illness (especially depression), physical illness, pain, functional impairment, and social disconnectedness. Recent advances in late-life suicide prevention have in common collaborative, multifaceted intervention designs. We suggest that one mechanism shared by all preventive interventions shown to reduce the incidence of late-life suicide is the promotion of connectedness. For the clinician working with older adults, our recommendation is to not only consider risk factors, such as depression, and implement appropriate treatments but to enhance social connectedness as well.

  10. Late Sovereign Diplomacy

    DEFF Research Database (Denmark)

    Adler-Nissen, Rebecca

    2009-01-01

    the promotion of national interests with those of the Union. In this late sovereign phase of diplomacy, political and legal authorities overlap, territorial exclusivity is replaced with functional boundaries, and states begin to speak with one voice. The article explores three interlinked aspects of late...... sovereign diplomacy: the teleological interpretation of the EC and EU treaties; the intense socialization of state representatives; and the negotiation process, which promotes national positions as part of a European cause, thereby delocalizing the national interest. While the EU has not rendered national...... diplomacy obsolete, it has profoundly changed its meaning and consequences....

  11. Early and late motherhood

    DEFF Research Database (Denmark)

    Christoffersen, Mogens; Lausten, Mette

    2009-01-01

    The study investigates parental child rearing methods, structural factors relating to the family during adolescence geographic segregation, individual resource deficits and social background of first time late live births among 32 to 37 years old women and compare to teenagers before becoming...... teenage mothers. The purpose is to study if results will be consistent with the hypotheses that poverty, social deprivation during adolescence and low education are causes of teen childbearing but also childlessness among elder women in the age group 32 to 37 years old. Could childlessness as well...... pregnant teenagers who had an induced abortion. Quite the opposite pattern is disclosed for late motherhood....

  12. Late Embryogenesis Abundant Proteins

    NARCIS (Netherlands)

    Shih, M.D.; Hoekstra, F.A.; Hsing, Y.I.C.

    2008-01-01

    During the late maturation stage of seed development, water content decreases greatly. One of the most striking characteristics of mature orthodox seeds is their ability to withstand severe desiccation. Mechanisms of plant drought/desiccation tolerance have been studied by numerous groups, and a bro

  13. Never Too Late

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    A historical issue is being raised on Capitol Hill.In late May,members of the U.S.Congress introduced bipartisan resolutions in both chambers,calling on the federal legislature to acknowledge formally and express regret for discriminatory legislation and how the country accordingly treated Chinese immigrants more than a century ago.

  14. Big Java late objects

    CERN Document Server

    Horstmann, Cay S

    2012-01-01

    Big Java: Late Objects is a comprehensive introduction to Java and computer programming, which focuses on the principles of programming, software engineering, and effective learning. It is designed for a two-semester first course in programming for computer science students.

  15. Was I Late

    Institute of Scientific and Technical Information of China (English)

    叶历来; 罗琪芳

    2011-01-01

    “Get up, Jane!” “Oh... Mom, let me sleep five more minutes. I'm so Ured ( 困的 ).” “It's 7:50. It's too late. ” “OK, three minutes then... Wait! What did you say? What time is it? It's 7:50.”

  16. Late-Onset Asthma

    DEFF Research Database (Denmark)

    Ulrik, Charlotte Suppli

    2017-01-01

    Late-onset asthma is common, associated with poor outcome, underdiagnosed and undertreated, possibly due to the modifying effect of ageing on disease expression. Although the diagnostic work-up in elderly individuals suspected of having asthma follows the same steps as in younger individuals (case......, to objectively confirm asthma. If necessary, a trial of oral or inhaled corticosteroid might be necessary. Asthma can be diagnosed when increased airflow variability is identified in a symptomatic patient, and if the patient does not have a history of exposure, primarily smoking, known to cause chronic...... obstructive pulmonary disease, the diagnosis is asthma even if the patient does not have fully reversible airflow obstruction. Pharmacological therapy in patients with late-onset asthma follows international guidelines, including treatment with the lowest effective dose of inhaled corticosteroid to minimize...

  17. Late Babylonian Astrology

    Science.gov (United States)

    Steele, John M.

    The last five centuries BC saw the development of several new forms of astrology in Babylonia. Key to these new astrological techniques was the invention of the zodiac in about 400 BC. These new forms of astrology include personal horoscopes, astral medicine, and the exploitation of geometrical relationships between the position of heavenly bodies. Several Late Babylonian astrological doctrines were later adopted within Greek astrology.

  18. Coping – Late Side Effects

    Science.gov (United States)

    Cancer treatment can cause late side effects that may not show up for months or years after treatment. These late effects may include heart and lung problems, bone loss, eye and hearing changes, lymphedema, and other problems

  19. Late-modern hipsters

    DEFF Research Database (Denmark)

    Andersen, Bjørn Schiermer

    2014-01-01

    The article deals with the cultural significance of a new figure in late-modern Western culture: the hipster. The current hipster culture, so I argue, can be used as a magnifying glass that makes impending changes to our conception of culture and of cultural development visible. It ushers in broa...... redemptive gesture toward the objects of the recent past and its predilection for irony. The article seeks to unfold hipster culture and sociality in an ongoing dialogue with sociological theory in general and conventional ways of thinking subculture in particular....

  20. Late-onset hypogonadism

    Directory of Open Access Journals (Sweden)

    Piotr Dudek

    2017-06-01

    Full Text Available In Poland, the number of men over the age of 50 years exceeds 6 million. It is estimated that about 2-6% of this population develops symptoms of late-onset hypogonadism (LOH. In men, testosterone deficiency increases slightly with age. LOH is a clinically and biochemically defined disease of older men with serum testosterone level below the reference parameters of younger healthy men and with symptoms of testosterone deficiency, manifested by pronounced disturbances of quality of life and harmful effects on multiple organ systems. Testosterone replacement therapy may give several benefits regarding body composition, metabolic control, and psychological and sexual parameters.

  1. Never too late.

    Science.gov (United States)

    1996-11-01

    Motivated by the belief that education has been central to Japan's economic success, Japan International Cooperation Agency (JICA) promotes universal access to quality basic education. In developing countries, school children rarely learn science through experiments. A new JICA training course, the Science Experiment in Primary Education, involved teacher trainers from Bangladesh, Myanmar, Pakistan, and Sri Lanka. Physics, chemistry, biology, geology, and astronomy experiments that require simple, inexpensive materials were taught. Another JICA project in Satkhira, Bangladesh, sought to raise the economic status of women enrolled in a dressmaking program through a year-long evening literacy class at three sites. Elementary school diplomas (available with proof to a local teacher of basic literacy and minimal arithmetic skills) are required in Bangladesh to apply for nongovernmental organization-initiated vocational schools and loans to start businesses in areas such as dressmaking, agriculture, and livestock raising. By late 1993, the female literacy program had expanded to 18 villages.

  2. Late-Modern Symbolism

    DEFF Research Database (Denmark)

    Andersen, Bjørn Schiermer

    2015-01-01

    Through analysis of key texts, I seek to demonstrate the explanative potential of Durkheim’s sociology of religion in the present context. I critically readdress the idea, found in his early work, that modernity is characterized by a rupture with pre-modern forms of solidarity. First, I investigate...... the ways in which Durkheim sets up a stark distinction between the pre-modern and the modern in his early work, and how this distinction is further cemented by his orthodox critique of the modern economy and its negative effects on social life. Second, I show how another timeless and positive understanding...... of “mechanical” solidarity is to be found behind the “symbolist” template crystalizing in Durkheim’s late work. Third, I develop this template for a modern context by critically addressing and removing other obstacles and prejudices on Durkheim’s part....

  3. Late Carboniferous to Late Permian carbon isotope stratigraphy

    DEFF Research Database (Denmark)

    Buggisch, Werner; Krainer, Karl; Schaffhauser, Maria

    2015-01-01

    An integrated study of the litho-, bio-, and isotope stratigraphy of carbonates in the Southern Alps was undertaken in order to better constrain δ13C variations during the Late Carboniferous to Late Permian. The presented high resolution isotope curves are based on 1299 δ13Ccarb and 396 δ13Corg a...

  4. Illusory Late Heavy Bombardments.

    Science.gov (United States)

    Boehnke, Patrick; Harrison, T Mark

    2016-09-27

    The Late Heavy Bombardment (LHB), a hypothesized impact spike at ∼3.9 Ga, is one of the major scientific concepts to emerge from Apollo-era lunar exploration. A significant portion of the evidence for the existence of the LHB comes from histograms of (40)Ar/(39)Ar "plateau" ages (i.e., regions selected on the basis of apparent isochroneity). However, due to lunar magmatism and overprinting from subsequent impact events, virtually all Apollo-era samples show evidence for (40)Ar/(39)Ar age spectrum disturbances, leaving open the possibility that partial (40)Ar* resetting could bias interpretation of bombardment histories due to plateaus yielding misleadingly young ages. We examine this possibility through a physical model of (40)Ar* diffusion in Apollo samples and test the uniqueness of the impact histories obtained by inverting plateau age histograms. Our results show that plateau histograms tend to yield age peaks, even in those cases where the input impact curve did not contain such a spike, in part due to the episodic nature of lunar crust or parent body formation. Restated, monotonically declining impact histories yield apparent age peaks that could be misinterpreted as LHB-type events. We further conclude that the assignment of apparent (40)Ar/(39)Ar plateau ages bears an undesirably high degree of subjectivity. When compounded by inappropriate interpretations of histograms constructed from plateau ages, interpretation of apparent, but illusory, impact spikes is likely.

  5. Recent casualties of late globalization

    DEFF Research Database (Denmark)

    Turcan, Romeo V.

    2016-01-01

    In this essay I will expand my thoughts on universities as ‘late globalizers’ and the impact ‘being late’ has on university internationalization or globalization activities. In my earlier essay I viewed universities as ‘late globalizers’ and briefly introduced the impact of being ‘late’, e...

  6. Recent casualties of late globalization

    DEFF Research Database (Denmark)

    Turcan, Romeo V.

    2016-01-01

    In this essay I will expand my thoughts on universities as ‘late globalizers’ and the impact ‘being late’ has on university internationalization or globalization activities. In my earlier essay I viewed universities as ‘late globalizers’ and briefly introduced the impact of being ‘late’, e.g., wi...

  7. Late-life attachment.

    Science.gov (United States)

    Freitas, Mélanie; Rahioui, Hassan

    2017-03-01

    Old age is likely to cause a crisis in one's life because of the vulnerabilities it brings up, acting as stressful elements disrupting the elder's feeling of security. It leads to the activation of what is called his attachment system, consisting in attachment styles and interpersonal emotional regulation strategies. To recover a higher sense of safety, the elder would refer to his attachment figures, that is to say closed people paying attention to him, showing towards him availability and consideration. However older adults particularly see their tolerance threshold lowered, regarding an accumulation of losses (true or symbolic) and stressful events within their lifetime. In a psychological and organic exhaustion phenomenon, the risk is to wear out the interpersonal emotional regulation strategies. These are as much vulnerabilities that may increase psychiatric decompensation, including depression. To resolve the tension of this period and to found a necessary secure feeling, the elder will have to redesign the attachment links previously settled and proceed to adjustments to this new context. The need of relational closeness comes back in the elders' attachment behaviour, counting on attachment figures not only to help their loneliness or dependency, but essentially to support them in a narcissist and affective way. That is why attachment theory enlightens the late life period, such as the new challenges older adults have to face. Many studies recognize its value in understanding the transition to old age, but without proposing conceptualization. We aim first to focus on attachment conception to say how much it is relevant with elderly, and then to describe specific terms of attachment within this population in order to better understand those patients. To finish, we must think about new therapeutic proposals taking into consideration the attachment perspective for a better understanding of old age transition.

  8. Vaginal bleeding in late pregnancy

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/patientinstructions/000627.htm Vaginal bleeding in late pregnancy To use the sharing features ... the blood from soaking your clothes. What Causes Bleeding Later in Pregnancy? When labor begins, the cervix ...

  9. Late and chronic Lyme disease.

    Science.gov (United States)

    Donta, Sam T

    2002-03-01

    This article reviews the late and chronic manifestations of Lyme disease. Special attention is given to the chronic manifestations of the disease, detailing its pathogenesis, clinical spectrum, and laboratory criteria for the diagnosis. Based on experimental evidence and experience, approaches to the successful treatment of the late and chronic disease are outlined. Much additional work is needed to improve the understanding of the underlying pathophysiology of the disease, its diagnosis and treatment.

  10. Late prematurity: a systematic review

    Directory of Open Access Journals (Sweden)

    Luís Carlos Machado Júnior

    2014-06-01

    Full Text Available Objective: this study aimed to review the literature regarding late preterm births (34 weeks to 36 weeks and 6 days of gestation in its several aspects. Sources: the MEDLINE, LILACS, and Cochrane Library databases were searched, and the references of the articles retrieved were also used, with no limit of time. Data synthesis: numerous studies showed a recent increase in late preterm births. In all series, late preterm comprised the majority of preterm births. Studies including millions of births showed a strong association between late preterm birth and neonatal mortality. A higher mortality in childhood and among young adults was also observed. Many studies found an association with several neonatal complications, and also with long-term disorders and sequelae: breastfeeding problems, cerebral palsy, asthma in childhood, poor school performance, schizophrenia, and young adult diabetes. Some authors propose strategies to reduce late preterm birth, or to improve neonatal outcome: use of antenatal corticosteroids, changes in some of the guidelines for early delivery in high-risk pregnancies, and changes in neonatal care for this group. Conclusions: numerous studies show greater mortality and morbidity in late preterm infants compared with term infants, in addition to long-term disorders. More recent studies evaluated strategies to improve the outcomes of these neonates. Further studies on these strategies are needed.

  11. Late prematurity: a systematic review.

    Science.gov (United States)

    Machado Júnior, Luís Carlos; Passini Júnior, Renato; Rodrigues Machado Rosa, Izilda

    2014-01-01

    this study aimed to review the literature regarding late preterm births (34 weeks to 36 weeks and 6 days of gestation) in its several aspects. the MEDLINE, LILACS, and Cochrane Library databases were searched, and the references of the articles retrieved were also used, with no limit of time. numerous studies showed a recent increase in late preterm births. In all series, late preterm comprised the majority of preterm births. Studies including millions of births showed a strong association between late preterm birth and neonatal mortality. A higher mortality in childhood and among young adults was also observed. Many studies found an association with several neonatal complications, and also with long-term disorders and sequelae: breastfeeding problems, cerebral palsy, asthma in childhood, poor school performance, schizophrenia, and young adult diabetes. Some authors propose strategies to reduce late preterm birth, or to improve neonatal outcome: use of antenatal corticosteroids, changes in some of the guidelines for early delivery in high-risk pregnancies, and changes in neonatal care for this group. numerous studies show greater mortality and morbidity in late preterm infants compared with term infants, in addition to long-term disorders. More recent studies evaluated strategies to improve the outcomes of these neonates. Further studies on these strategies are needed. Copyright © 2014 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.

  12. Late effects from hadron therapy

    Energy Technology Data Exchange (ETDEWEB)

    Blakely, Eleanor A.; Chang, Polly Y.

    2004-06-01

    Successful cancer patient survival and local tumor control from hadron radiotherapy warrant a discussion of potential secondary late effects from the radiation. The study of late-appearing clinical effects from particle beams of protons, carbon, or heavier ions is a relatively new field with few data. However, new clinical information is available from pioneer hadron radiotherapy programs in the USA, Japan, Germany and Switzerland. This paper will review available data on late tissue effects from particle radiation exposures, and discuss its importance to the future of hadron therapy. Potential late radiation effects are associated with irradiated normal tissue volumes at risk that in many cases can be reduced with hadron therapy. However, normal tissues present within hadron treatment volumes can demonstrate enhanced responses compared to conventional modes of therapy. Late endpoints of concern include induction of secondary cancers, cataract, fibrosis, neurodegeneration, vascular damage, and immunological, endocrine and hereditary effects. Low-dose tissue effects at tumor margins need further study, and there is need for more acute molecular studies underlying late effects of hadron therapy.

  13. Late effects from hadron therapy.

    Science.gov (United States)

    Blakely, Eleanor A; Chang, Polly Y

    2004-12-01

    Successful cancer patient survival and local tumor control from hadron radiotherapy warrant a discussion of potential secondary late effects from the radiation. The study of late-appearing clinical effects from particle beams of protons, carbon, or heavier ions is a relatively new field with few data. However, new clinical information is available from pioneer hadron radiotherapy programs in the USA, Japan, Germany and Switzerland. This paper will review available data on late tissue effects from particle radiation exposures, and discuss its importance to the future of hadron therapy. Potential late radiation effects are associated with irradiated normal tissue volumes at risk that in many cases can be reduced with hadron therapy. However, normal tissues present within hadron treatment volumes can demonstrate enhanced responses compared to conventional modes of therapy. Late endpoints of concern include induction of secondary cancers, cataract, fibrosis, neurodegeneration, vascular damage, and immunological, endocrine and hereditary effects. Low-dose tissue effects at tumor margins need further study, and there is need for more acute molecular studies underlying late effects of hadron therapy.

  14. The effects of Mixing offenders with Non-offenders

    DEFF Research Database (Denmark)

    Minke, Linda Annette Kjær

    2011-01-01

    Effekten af at blande kriminelle og ikke-kriminelle på en af kriminalforsorgens pensioner er undersøgt ved hjælp af kvalitative og kvantitative metoder. Til undersøgelsen er der dannet en sammenlignelig kontrolgruppe bestående af godt 3000 indsatte fra kriminalforsorgens pensioner, der er sammenl...

  15. Nonoffending Caregiver and Youth Experiences with Child Sexual Abuse Investigations

    Science.gov (United States)

    Jones, Lisa M.; Atoro, Kathryn E.; Walsh, Wendy A.; Cross, Theodore P.; Shadoin, Amy L.; Magnuson, Suzanne

    2010-01-01

    Qualitative responses by caregivers (n = 203) and youth (aged 8 and older; n = 65) about their experiences with sexual abuse investigations were analyzed in conjunction with quantitative ratings of satisfaction. Respondents described mostly high levels of satisfaction, although dissatisfaction was reported with some key aspects of investigations.…

  16. Late sequelae of superficial irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Hood, I.C.; Young, J.E.

    1984-10-01

    Superficial irradiation results in well recognized late sequelae including not only sclerosis and atrophy of skin and subcutaneous tissue, but also the development of benign and malignant tumors of skin and adjacent structures. The long latency between irradiation and its late effects allowed the early uncontrolled use of radiation treatment for benign conditions. The subsequent recognition of the causal relationship between tumors and previous irradiation has restricted its use to more appropriate purposes, although it is possible that it is still overused in some areas of dermatologic practice. Clinicians need to be aware of the time interval between irradiation and the development of its late sequelae, and the incidence of these sequelae. Appropriate irradiation exposure history should be a part of the evaluation of every patient.

  17. [Late-onset dysthymic states].

    Science.gov (United States)

    Siranchiev, M A

    2002-01-01

    Sixty patients with dysthymic states which had emerged in later age of 60-80 years were examined. Two clinical types of dysthymic states were described: anergic (20 patients) and hypothymic (40 patients). Different comorbid mental disorders--obsessive-phobic (14 cases), somatoform (10), personality deviations (20) and psycho-organic (7)--were found to be characteristic of late-onset dysthymic states. According to developmental features, late dysthymia was primary (first manifested in the elderly) and secondary (develops after several depressive episodes). In diagnostic terms, the former is considered as "dysthymia" (F34.1 ICD-10) and the latter--as "recurrent depressive disorder" (F33).

  18. LATE ONSET ATRIOVENTRICULAR NODAL TACHYCARDIA

    NARCIS (Netherlands)

    PENTINGA, ML; MEEDER, JG; CRIJNS, HJGM; DEMUINCK, ED; WIESFELD, ACP; LIE, KI

    AV nodal tachycardia may present at any age, but onset in late adulthood is considered uncommon. To evaluate whether onset of AV nodal tachycardias at older age is related to organic heart disease (possibly setting the stage for re-entry due to degenerative structural changes) 32 consecutive

  19. Late onset globoid cell leukodystrophy.

    Science.gov (United States)

    Grewal, R P; Petronas, N; Barton, N W

    1991-11-01

    A 29 year old male with onset of globoid cell leukodystrophy at age 14 is described. This is the first case of enzymatically confirmed globoid cell leukodystrophy with onset of symptoms after the age of ten. This patient is unique because of the late onset and slow progression and extends the clinical spectrum of globoid cell leukodystrophy.

  20. Clerical Exile in Late Antiquity

    DEFF Research Database (Denmark)

    Engberg, Jakob

    2016-01-01

    This volume results from the international research project ‘The Migration of Faith: Clerical Exile in Late Antiquity (325‒c.600)’. The project is a collaboration between the Department of History at the University of Sheffield, the Seminar für Kirchengeschichte at the University of Halle, and th...

  1. LATE ONSET ATRIOVENTRICULAR NODAL TACHYCARDIA

    NARCIS (Netherlands)

    PENTINGA, ML; MEEDER, JG; CRIJNS, HJGM; DEMUINCK, ED; WIESFELD, ACP; LIE, KI

    1993-01-01

    AV nodal tachycardia may present at any age, but onset in late adulthood is considered uncommon. To evaluate whether onset of AV nodal tachycardias at older age is related to organic heart disease (possibly setting the stage for re-entry due to degenerative structural changes) 32 consecutive patient

  2. Late onset startle induced tics

    NARCIS (Netherlands)

    Tijssen, MAJ; Brown, P; Morris, HR; Lees, A

    1999-01-01

    Three cases of late onset Gilles de la Tourette's syndrome are presented. The motor ties were mainly induced by an unexpected startling stimulus, but the startle reflex was not exaggerated. The ties developed after physical trauma or a period of undue emotional stress. Reflex ties may occur in

  3. Late onset startle induced tics

    NARCIS (Netherlands)

    Tijssen, MAJ; Brown, P; Morris, HR; Lees, A

    1999-01-01

    Three cases of late onset Gilles de la Tourette's syndrome are presented. The motor ties were mainly induced by an unexpected startling stimulus, but the startle reflex was not exaggerated. The ties developed after physical trauma or a period of undue emotional stress. Reflex ties may occur in Gille

  4. Late detection of cleft palate

    NARCIS (Netherlands)

    Hanny, K H; de Vries, I A C; Haverkamp, S J; Oomen, K P Q; Penris, W M; Eijkemans, M J C; Kon, M; Mink van der Molen, A B; Breugem, C C

    2016-01-01

    Cleft palate only (CPO) is a common congenital malformation, and most patients are diagnosed within the first weeks after birth. Late diagnosis of the cleft palate (CP) could initially result in feeding and growth impairment, and subsequently speech and hearing problems later in life. The purpose of

  5. Late onset clozapine induced agranulocytosis

    Directory of Open Access Journals (Sweden)

    Rajmohan Velayudhan

    2014-01-01

    Full Text Available Agranulocytosis is defined as an absolute neutrophil count less than 100/mm 3 in association with infectious disease. The risk of agranulocytosis is 0.38% of all clozapine treated cases and there is a relatively lesser incidence in Indian population. The risk of clozapine-induced agranulocytosis and neutropenia is highest in the first 6 months and higher in the initial 18 months after the onset of treatment. There have been very few reports of neutropenia and agranulocytosis after this period. There have so far been no reports of late onset clozapine induced agranulocytosis has been reported from India. A case of late onset clozapine induced agranulocytosis with possible mechanism of the same is reported.

  6. Monomelic amyotrophy with late progression.

    Science.gov (United States)

    Rowin, J; Meriggioli, M N; Cochran, E J

    2001-04-01

    Monomelic amyotrophy is a sporadic juvenile-onset disease that presents with gradual onset of weakness and atrophy in the hand muscles unilaterally. Generally, this disease is considered a 'benign' and non-progressive motor neuron disease, which stabilizes within five years of onset. We discuss a case that illustrates that monomelic amyotrophy may rarely exhibit late clinical progression to the lower extremities after a prolonged period of disease stability.

  7. Late colonization of Easter Island.

    Science.gov (United States)

    Hunt, Terry L; Lipo, Carl P

    2006-03-17

    Easter Island (Rapa Nui) provides a model of human-induced environmental degradation. A reliable chronology is central to understanding the cultural, ecological, and demographic processes involved. Radiocarbon dates for the earliest stratigraphic layers at Anakena, Easter Island, and analysis of previous radiocarbon dates imply that the island was colonized late, about 1200 A.D. Substantial ecological impacts and major cultural investments in monumental architecture and statuary thus began soon after initial settlement.

  8. Late evolution of planetary systems

    Energy Technology Data Exchange (ETDEWEB)

    Morbidelli, A [CNRS, Observatoire de la Cote d' Azur, B P 4299, 06304 Nice Cedex 4 (France); Levison, H F [SWRI, 1050 Walnut St, Suite 300 Boulder, CO 80302 (United States)], E-mail: morby@obs-nice.fr, E-mail: hal@boulder.swri.edu

    2008-08-15

    This chapter discusses some of the main effects of the interaction of planets with remnant planetesimal disks, after the disappearance of the gas. It focuses on planet migration and its possible outcomes. In particular, we discuss the possibility that the migration of the planets leads them into an unstable configuration which changes drastically the structure of the system. The late heavy bombardment (LHB) of the terrestrial planets, occurring 650 Myr after planet formation, is a strong indication that this kind of evolution occurred in our solar system. Other stars show evidence of intense comet showers, which may indicate that LHB-analogs are ongoing in those systems at the current time.

  9. [Left pulmonary agenesis diagnosed late].

    Science.gov (United States)

    Deleanu, Oana; Pătraşcu, Natalia; Nebunoiu, Ana-Maria; Vintilă, V; Ulmeanu, Ruxandra; Mihălţan, F D

    2010-01-01

    We present the case of a 51 years old female-patient, with severe dextroscoliosis, having like unique symptom progressive dyspnea. The blood samples reveals polycythemia, the radiological exam shows the opacification of 2/3 of the left thorax, the absence of the lung structure in the other 1/3, the deviation of the mediastinum, and dextroscoliosis; the computed tomography reveals the absence of the left lung artery and the left airways, compensatory hyperinflation of the right lung and dilatation of the trunk and right pulmonary artery; the bronchoscopy does not visualize the carina or the left main bronchus, typical for pulmonary agenesis. Echocardiography confirmed the absence of left pulmonary artery and shows mild pulmonary hypertension (systolic pressure in the pulmonary artery of 33 mmHg) with dilatation of the right cavities, but good cinetics. We face a case of pulmonary agenesis lately diagnosed, with modest functional cardiologic implications, limited therapeutic options and good survival, justified by the late appearance of the pulmonary hypertension of low severity and without worsening in time.

  10. Processing of Baculovirus Late and Very Late mRNAs

    Institute of Scientific and Technical Information of China (English)

    Linda A. Guarino

    2007-01-01

    Baculoviruses encode a DNA-directed RNA polymerase that is evolutionarily divergent from cellular polymerases. This RNA polymerase is a multifunctional complex that has the ability to recognize late promoters, transcribe linked genes, and process transcripts at both the 5' and 3' ends. The LEF-4 subunit of the viral RNA polymerase is the mRNA capping enzyme, with both RNA triphosphatase and guanylyltransferase activities. Conversion to cap 1 structures is mediated by the viral enzyme MTase1 and another as yet unidentified methyltransferase. Termination is an intrinsic property of the viral RNA polymerase and occurs at oligoU rich sequences. Polyadenylation of the released transcripts is also a function of the viral RNA polymerase. Thus, although viral mRNAs resemble host messages with respect to their 5' and 3' end structures, the processing is mediated by viral enzymes and, in the case of the 3' ends, by mechanisms that differ from the host cell.

  11. Late veneer and late accretion to the terrestrial planets

    Science.gov (United States)

    Brasser, R.; Mojzsis, S. J.; Werner, S. C.; Matsumura, S.; Ida, S.

    2016-12-01

    It is generally accepted that silicate-metal ('rocky') planet formation relies on coagulation from a mixture of sub-Mars sized planetary embryos and (smaller) planetesimals that dynamically emerge from the evolving circum-solar disc in the first few million years of our Solar System. Once the planets have, for the most part, assembled after a giant impact phase, they continue to be bombarded by a multitude of planetesimals left over from accretion. Here we place limits on the mass and evolution of these planetesimals based on constraints from the highly siderophile element (HSE) budget of the Moon. Outcomes from a combination of N-body and Monte Carlo simulations of planet formation lead us to four key conclusions about the nature of this early epoch. First, matching the terrestrial to lunar HSE ratio requires either that the late veneer on Earth consisted of a single lunar-size impactor striking the Earth before 4.45 Ga, or that it originated from the impact that created the Moon. An added complication is that analysis of lunar samples indicates the Moon does not preserve convincing evidence for a late veneer like Earth. Second, the expected chondritic veneer component on Mars is 0.06 weight percent. Third, the flux of terrestrial impactors must have been low (≲10-6 M⊕ Myr-1) to avoid wholesale melting of Earth's crust after 4.4 Ga, and to simultaneously match the number of observed lunar basins. This conclusion leads to an Hadean eon which is more clement than assumed previously. Last, after the terrestrial planets had fully formed, the mass in remnant planetesimals was ∼10-3 M⊕, lower by at least an order of magnitude than most previous models suggest. Our dynamically and geochemically self-consistent scenario requires that future N-body simulations of rocky planet formation either directly incorporate collisional grinding or rely on pebble accretion.

  12. Antibiotics in late clinical development.

    Science.gov (United States)

    Fernandes, Prabhavathi; Martens, Evan

    2017-06-01

    Most pharmaceutical companies have stopped or have severely limited investments to discover and develop new antibiotics to treat the increasing prevalence of infections caused by multi-drug resistant bacteria, because the return on investment has been mostly negative for antibiotics that received marketing approved in the last few decades. In contrast, a few small companies have taken on this challenge and are developing new antibiotics. This review describes those antibiotics in late-stage clinical development. Most of them belong to existing antibiotic classes and a few with a narrow spectrum of activity are novel compounds directed against novel targets. The reasons for some of the past failures to find new molecules and a path forward to help attract investments to fund discovery of new antibiotics are described. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  13. Late hemorrhagic disease of newborn.

    Science.gov (United States)

    D'Souza, I E; Rao, S D Subba

    2003-03-01

    The clinical features of 14 infants diagnosed with late hemorrhagic disease of newborn (LHDN), of which 10 did not receive vitamin K prophylaxis, are presented. All infants were exclusively breast-fed and 12 did not have any underlying illness to explain the abnormal coagulation profile. The common presenting symptoms were seizures (71%), vomiting (57%), poor feeding (50%) and altered sensorium (36%). Physical examination shared pallor in all infants and a bulging anterior fontanel in 64%. Intracranial bleed was the predominant manifestation (93%), with CT scan showing intracranial bleed in 78%. Eight infants (57%) succumbed to their illness, while 36%had neurological sequelae. Since LHDN leads to significant morbidity and mortality, it should be prevented by providing vitamin K prophylaxis to all newborns.

  14. Streptococcosis in seabass (Lates calcarifer

    Directory of Open Access Journals (Sweden)

    Wanman, C.

    2005-02-01

    Full Text Available Streptococcus sp. isolated from infected seabass (Lates calcarifer can grow on medium at pH 9.6 and salinity 0 ppt. The lethal dose where the mortality is 50 percent (LD50 was 1.937×103 CFU/ml after 14 days. Diseased fish showed dark body coloration, erratic swimming, exophthalmia, dropsy, pale liver, splenomegaly and hemorrhage in the brain. Blood parameters i.e. haematocrit, haemoglobin, plasma protein and red blood cell of infected fish were decreased, while white blood cells were increased. Histopathological changes in diseased seabass were necrosis, vacuolization and granuloma of the liver, increased number of melanomacrophage in liver and spleen, shrinkage of glomerulus in kidneys, inflammation and necrosis of the spleen and heart, hyperplasia and telangiectasis of the gill, while vacuolization and capsulation of the exophthalmic eyes were observed.

  15. Late onset hereditary episodic ataxia.

    Science.gov (United States)

    Damak, M; Riant, F; Boukobza, M; Tournier-Lasserve, E; Bousser, M-G; Vahedi, K

    2009-05-01

    Episodic ataxias (EA) are hereditary paroxysmal neurological diseases with considerable clinical and genetic heterogeneity. So far seven loci have been reported and four different genes have been identified. Analysis of additional sporadic or familial cases is needed to better delineate the clinical and genetic spectrum of EA. A two generation French family with late onset episodic ataxia was examined. All consenting family members had a brain MRI with volumetric analysis of the cerebellum. Haplotype analysis was performed for the EA2 locus (19p13), the EA5 locus (2q22), the EA6 locus (5p13) and the EA7 locus (19q13). Mutation screening was performed for all exons of CACNA1A (EA2), EAAT1 (EA6) and the coding sequence of KCNA1 (EA1). Four family members had episodic ataxia with onset between 48 and 56 years of age but with heterogeneity in the severity and duration of symptoms. The two most severely affected had daily attacks of EA with a slowly progressive and disabling permanent cerebellar ataxia and a poor response to acetazolamide. Brain MRI showed in three affected members a decrease in the ratio of cerebellar volume:total intracranial volume, indicating cerebellar atrophy. No deleterious mutation was found in CACNA1A, SCA6, EAAT1 or KCNA1. In addition, the EA5 locus was excluded. A new phenotype of episodic ataxia has been described, characterised clinically by a late onset and progressive permanent cerebellar signs, and genetically by exclusion of the genes so far identified in EA.

  16. Late veneer and late accretion to the terrestrial planets

    CERN Document Server

    Brasser, R; Werner, S C; Matsumura, S; Ida, S

    2016-01-01

    It is generally accepted that silicate-metal (`rocky') planet formation relies on coagulation from a mixture of sub-Mars sized planetary embryos and (smaller) planetesimals that dynamically emerge from the evolving circum-solar disc in the first few million years of our Solar System. Once the planets have, for the most part, assembled after a giant impact phase, they continue to be bombarded by a multitude of planetesimals left over from accretion. Here we place limits on the mass and evolution of these planetesimals based on constraints from the highly siderophile element (HSE) budget of the Moon. Outcomes from a combination of N-body and Monte Carlo simulations of planet formation lead us to four key conclusions about the nature of this early epoch. First, matching the terrestrial to lunar HSE ratio requires either that the late veneer on Earth consisted of a single lunar-size impactor striking the Earth before 4.45 Ga, or that it originated from the impact that created the Moon. An added complication is th...

  17. Causes for Late onset Alcohol Use Disorder

    DEFF Research Database (Denmark)

    Emiliussen, Jakob; Nielsen, Anette Søgaard; Andersen, Kjeld

    the available literature on the subject. Method A PRISMA style review and search was performed in late May 2014 and covered MEDLINE, EMBASE, PubMed, and PsychInfo. Inclusion was based on if the study had causes for late-onset AUD in their results section. This revealed 24 articles relevant for this study. After...... not increase the risk for late-onset AUD. However, the data was insufficient to give a reliable quantification of these associations. Discussion A common problem for the studies included (and the ones excluded as well) was the lack of common definitions of late-onset, “stress” and “traumatic life events...

  18. Severe Anaemia during Late Pregnancy

    Directory of Open Access Journals (Sweden)

    Mahenaz Akhtar

    2012-01-01

    Full Text Available Vitamin B12 deficiency is uncommon in pregnancy, it occurs in 10–28% of uncomplicated pregnancies, and is associated with a few complications. We present a case report of a 21-year-old patient with severe anaemia during late pregnancy caused by vitamin B12 deficiency. At 38 weeks gestation and with a BMI of 48.9, a history of rupture of membranes was given but not confirmed. On examination, she appeared pale and therefore full blood counts were done. Interestingly her haemoglobin (Hb levels were 3.7 g/dL. Folate and vitamin B12 levels were also found to be low, and the diagnosis of anaemia caused by vitamin B12 deficiency was made. After treatment with vitamin B12 injections, folic acid and blood transfusions, the patient’s haemoglobin levels improved from 3.7 g/dL to 10.7 g/dL. The conclusion is that effective history taking, diagnosis, and management can prevent many complications that are usually associated with vitamin B12 deficiency anaemia.

  19. Late complications of radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Masaki, Norie [Osaka Prefectural Center for Adult Diseases (Japan)

    1998-03-01

    There are cases in which, although all traces of acute radiation complications seem to have disappeared, late complications may appear months or years to become apparent. Trauma, infection or chemotherapy may sometimes recall radiation damage and irreversible change. There were two cases of breast cancer that received an estimated skin dose in the 6000 cGy range followed by extirpation of the residual tumor. The one (12 y.o.) developed atrophy of the breast and severe teleangiectasis 18 years later radiotherapy. The other one (42 y.o.) developed severe skin necrosis twenty years later radiotherapy after administration of chemotherapy and received skin graft. A case (52 y.o.) of adenoidcystic carcinoma of the trachea received radiation therapy. The field included the thoracic spinal cord which received 6800 cGy. Two years and 8 months after radiation therapy she developed complete paraplegia and died 5 years later. A truly successful therapeutic outcome requires that the patient be alive, cured and free of significant treatment-related morbidity. As such, it is important to assess quality of life in long-term survivors of cancer treatment. (author)

  20. Late Registration: May It Rest in Peace

    Science.gov (United States)

    O'Banion, Terry

    2012-01-01

    Almost every institution of higher education engages in late registration. But evidence is mounting that the practice, originally intended to keep the doors of opportunity open for students as long as possible, wreaks havoc on the ability of colleges to achieve the goals of the emerging completion agenda. Despite best intentions, late registration…

  1. Late Registration: May It Rest in Peace

    Science.gov (United States)

    O'Banion, Terry

    2012-01-01

    Almost every institution of higher education engages in late registration. But evidence is mounting that the practice, originally intended to keep the doors of opportunity open for students as long as possible, wreaks havoc on the ability of colleges to achieve the goals of the emerging completion agenda. Despite best intentions, late registration…

  2. Childhood abuse in late-life depression

    NARCIS (Netherlands)

    Comijs, Hannie C; van Exel, Eric; van der Mast, Roos C; Paauw, Anna; Oude Voshaar, Richard; Stek, Max L

    2013-01-01

    Background: Little is known about the role of childhood abuse in late-life depression. The aim of the study is therefore to study whether childhood abuse is associated with late-life depression according to its onset, and which clinical characteristics play a role in this association. Methods: Data

  3. Childhood abuse in late-life depression

    NARCIS (Netherlands)

    Comijs, H.C.; Exel, E. van; Mast, R.C. van der; Paauw, A.; Oude Voshaar, R.C.; Stek, M.L.

    2013-01-01

    BACKGROUND: Little is known about the role of childhood abuse in late-life depression. The aim of the study is therefore to study whether childhood abuse is associated with late-life depression according to its onset, and which clinical characteristics play a role in this association. METHODS: Data

  4. 16 CFR 444.4 - Late charges.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Late charges. 444.4 Section 444.4 Commercial Practices FEDERAL TRADE COMMISSION TRADE REGULATION RULES CREDIT PRACTICES § 444.4 Late charges. (a) In connection with collecting a debt arising out of an extension of credit to a consumer in or...

  5. Childhood abuse in late-life depression

    NARCIS (Netherlands)

    Comijs, Hannie C; van Exel, Eric; van der Mast, Roos C; Paauw, Anna; Oude Voshaar, Richard; Stek, Max L

    Background: Little is known about the role of childhood abuse in late-life depression. The aim of the study is therefore to study whether childhood abuse is associated with late-life depression according to its onset, and which clinical characteristics play a role in this association. Methods: Data

  6. 7 CFR 925.141 - Late payments.

    Science.gov (United States)

    2010-01-01

    ... payment charge of 5 percent on the unpaid balance on any handler whose assessment has not been received in... rate of 11/2 percent per month shall be applied to the unpaid balance and late payment charge for the... 7 Agriculture 8 2010-01-01 2010-01-01 false Late payments. 925.141 Section 925.141...

  7. Cycads: Fossil evidence of late paleozoic origin

    Science.gov (United States)

    Mamay, S.H.

    1969-01-01

    Plant fossils from Lower Permian strata of the southwestern United States have been interpreted as cycadalean megasporophylls. They are evidently descended from spermopterid elements of the Pennsylvanian Taeniopteris complex; thus the known fossil history of the cycads is extended from the Late Triassic into the late Paleozoic. Possible implications of the Permian fossils toward evolution of the angiosperm carpel are considered.

  8. Are we ready to predict late effects?

    DEFF Research Database (Denmark)

    Salz, Talya; Baxi, Shrujal S; Raghunathan, Nirupa;

    2015-01-01

    BACKGROUND: After completing treatment for cancer, survivors may experience late effects: consequences of treatment that persist or arise after a latent period. PURPOSE: To identify and describe all models that predict the risk of late effects and could be used in clinical practice. DATA SOURCES:...

  9. Late Abortion: A Comprehensive Review

    Directory of Open Access Journals (Sweden)

    Sheng Chiang

    2005-12-01

    Full Text Available Late termination of pregnancy (LTOP is defined as an abortion carried out beyond 24 gestational weeks, when the fetus has arguably attained viability. In Taiwan, the current abortion law, bearing a eugenic title, allows LTOP on certain medical grounds. However, the fetal and maternal conditions that constitute medical grounds are not clarified and remain legally untested. Professional debate on the abortion issue is also lacking in academia in Taiwan, despite societal concerns. With the advent of technology to detect fetal abnormalities, obstetricians are now confronted more frequently with acute dilemmas regarding LTOP. Quite often, they sail in an uncharted sea with no clinical guidelines from their professional societies or affiliated hospitals. Recently, LTOP at 35 gestational weeks for a fetus with Down syndrome, complicated with polyhydramnios and tetralogy of Fallot, triggered media scrutiny and aroused much public attention. Although the clinical decision making for pregnancies with fetal abnormalities entails increasingly balanced information and consideration in terms of the medical, ethical, legal, psychologic, and societal aspects, society at large is unaware of the complexity and intertwined nature of various abortion issues, especially LTOP. Obstetricians are now in a vulnerable position in Taiwanese society, where litigations relevant to the practice of early abortions are not rare. Therefore, a global and in-depth look into abortion issues from legal and ethical dimensions is indispensable for modern obstetric practice. This review considers the core issues in LTOP, including what conditions constitute a “serious” fetal abnormality to justify LTOP, the incidence of LTOP, legislation regarding LTOP in Western countries, and recent research on ambivalent fetal pain. It will also present procedures, some under the auspices of the ethical committee of a Presbyterian hospital in Taiwan, for clinical decision making, particularly

  10. Cholesterol and late-life cognitive decline.

    Science.gov (United States)

    van Vliet, Peter

    2012-01-01

    High cholesterol levels are a major risk factor for cardiovascular disease, but their role in dementia and cognitive decline is less clear. This review highlights current knowledge on the role of cholesterol in late-life cognitive function, cognitive decline, and dementia. When measured in midlife, high cholesterol levels associate with an increased risk of late-life dementia and cognitive decline. However, when measured in late-life, high cholesterol levels show no association with cognitive function, or even show an inverse relation. Although statin treatment has been shown to associate with a lower risk of dementia and cognitive decline in observational studies, randomized controlled trials show no beneficial effect of statin treatment on late-life cognitive function. Lowering cholesterol levels may impair brain function, since cholesterol is essential for synapse formation and maturation and plays an important role in the regulation of signal transduction through its function as a component of the cell membrane. However, membrane cholesterol also plays a role in the formation and aggregation of amyloid-β. Factors that influence cholesterol metabolism, such as dietary intake, are shown to play a role in late-life cognitive function and the risk of dementia. In conclusion, cholesterol associates with late-life cognitive function, but the association is strongly age-dependent. There is no evidence that treatment with statins in late-life has a beneficial effect on cognitive function.

  11. Experimental late brood surveys: Southern Saskatchewan: 1991

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report summarizes the late brood surveys for southern Saskatchewan during 1991. Survey methods, weather and habitat conditions, production indices, and tables...

  12. Late onset depression: A recent update

    Directory of Open Access Journals (Sweden)

    Ananya Mahapatra

    2015-01-01

    Full Text Available Late onset depression has recently emerged as a serious mental health issue in the geriatric population with significant public health implications. It is often challenging to diagnose and treat this entity. Various theories have been postulated to elucidate the etiology of late onset depression, but a unifying hypothesis is lacking. Although the vascular hypothesis is most researched; a complex interaction of multiple vulnerability factors is the current focus of attention. Numerous psychosocial variables have been implicated to play a significant role in predicting the onset and severity of late-life depression. Phenomenological differences have been delineated from depression occurring at a younger age, but the findings are equivocal. A better understanding of the natural trajectory of depression in the elderly is required for early diagnosis and effective treatment. This review attempts to summarize the current status of evidence regarding epidemiology, etiology, clinical features, and treatment options available for late-onset depression.

  13. Late Amazonian Glaciations in Utopia Planitia, Mars

    Science.gov (United States)

    Osinski, G. R.; Capitan, R. D.; Kerrigan, M.; Barry, N.; Blain, S.

    2012-03-01

    We present evidence from western Utopia Planitia, including lineated valley fill and lobate debris aprons, for widespread glaciations over a large expanse of the northern plains and dichotomy boundary during Late Amazonian times.

  14. LATE TRIASSIC (LATE NORIAN-RHAETIAN RADIOLARIANS FROM THE ANTALYA NAPPES, CENTRAL TAURIDES, SOUTHERN TURKEY

    Directory of Open Access Journals (Sweden)

    UGUR KAGAN TEKIN

    2002-11-01

    Full Text Available The Hocaköy section measured from the Alakirçay Nappe (middle nappe of the Antalya Nappes contain rich radiolarian fauna ranging from late Norian (Late Triassic to middle-late Cenomanian (mid Cretaceous. At the basal part of the section, the Late Triassic (late Norian-Rhaetian Gökdere Formation is characterized by gray to beige cherty limestone at the base and pinkish red chert- gray to beige limestone alternation at the top, with moderately to well-preserved radiolarians in the red chert beds. The overlying Jurassic - Middle Cretaceous Hocaköy Radiolarite is mainly represented by chert-mudstone alternations with some limestone interlayers. Radiolarians of the Gökdere Formation can be well correlated with that of the fauna from the Mino Terrane, central Japan and the fauna from the Queen Charlotte Islands, British Columbia, Canada. Four radiolarian zones from central Japan are recognized in the fauna obtained from Gökdere Formation such as “Praemesosaturnalis multidentatus Lowest Occurrence Zone (TR8A” (late Norian, “Praemesosaturnalis pseudokahleri Lowest Occurrence Zone (TR8B” (late Norian, ? “ Skirt F lowest Occurrence Zone (TR8C” (late Norian-Rhaetian and partly “Haeckelicyrtium breviora Taxon Range Zone (TR8D” (Rhaetian. In comparison with the Queen Charlotte fauna, the two zones “Betraccium deweveri Zone” (late Norian and “Proparvicingula moniliformis Zone” (early Rhaetian are also encountered in the Gökdere Formation. Radiolarians of the uppermost part of the Gökdere Formation indicate that “Globolaxtorum tozeri Zone” defined in Queen Charlotte Islands corresponding to the late Rhaetian, is not present in the section. Five new taxa, Capnuchosphaera okayi, Bistarkum rhaeticum, Praemesosaturnalis heilongjiangensis aksekiensis, P. nobleae, Veghicyclia sanfilippoae were determined within the late Norian-Rhaetian radiolarian fauna of the Gökdere Formation in Hocaköy section.   

  15. Precursors and Correlates of Anxiety Trajectories from Late Childhood to Late Adolescence

    Science.gov (United States)

    Letcher, Primrose; Sanson, Ann; Smart, Diana; Toumbourou, John W.

    2012-01-01

    The present research employed a prospective, multi-informant design to examine precursors and correlates of differing anxiety profiles from late childhood to late adolescence. The sample consisted of 626 boys and 667 girls who are participants in the Australian Temperament Project, a large, longitudinal, community-based study that has followed…

  16. Late effects of thoracic irradiation in children

    Energy Technology Data Exchange (ETDEWEB)

    Boelling, T.; Koenemann, S.; Ernst, I.; Willich, N. [Dept. of Radiotherapy, Univ. Hospital of Muenster (Germany)

    2008-06-15

    Purpose: to summarize the literature regarding the late effects of radiotherapy to the thorax in childhood and adolescence with special emphasis on cardiac and pulmonary impairment. Material und methods: the literature was critically reviewed using the PubMed {sup registered} database with the key words 'late effects', 'late sequelae', 'child', 'childhood', 'adolescence', 'radiation', 'radiotherapy', 'thorax', 'lung', 'heart', and 'pulmonary'. Results: 17 publications dealing with radiation-induced pulmonary and cardiac late sequelae in children could be identified and were analyzed in detail. 29 further publications with additional information were also included in the analysis. Pulmonary function impairment after mediastinal irradiation arose in one third of all pediatric patients, even when treatment was performed with normofractionated lower doses (15-25 Gy). Whole lung irradiation was regularly followed by pulmonary function impairment with differing rates in several reports. However, clinically symptomatic function impairment like dyspnea was less frequent. Irradiation of up to 25 Gy (single doses {<=} 2 Gy) to the heart showed little or no cardiac toxicity in analyses of irradiated children (median follow-up 1.3-14.3 years). Doses of > 25 Gy (single doses {<=} 2-3.3 Gy) led to several cardiac dysfunctions. However, new data from adults with longer follow-up may indicate threshold doses as low as 1 Gy. Impairment of skeletal growth, breast hypoplasia, and secondary malignancy were further potential late sequelae. Conclusion: several retrospective reports described radiation-associated late sequelae in children. However, there is still a lack of sufficient data regarding the characterization of dose-volume effects. (orig.)

  17. Infrared Observations of Late Type Stars

    Science.gov (United States)

    Merrill, K. M.

    1977-01-01

    Substantive mass loss resulting in appreciable circumstellar dust envelopes is common in late-type stars. The evolutionary history and physical state of a cool star determine the chemistry within the outer stellar atmosphere mirrored by the molecular and particulate material present in the envelope. The observational consequences of this debris determined by moderate spectral resolution infrared spectrophotometry are reviewed. Significant information is provided by observations of the emergent energy flux of both the cool stellar photosphere and of the circumstellar dust envelope. The observation suggests that mass-loss occurs to some degree throughout late stellar evolutionary phases and that occasional periods of high mass loss are not uncommon.

  18. Late Cretaceous vicariance in Gondwanan amphibians.

    Directory of Open Access Journals (Sweden)

    Ines Van Bocxlaer

    Full Text Available Overseas dispersals are often invoked when Southern Hemisphere terrestrial and freshwater organism phylogenies do not fit the sequence or timing of Gondwana fragmentation. We used dispersal-vicariance analyses and molecular timetrees to show that two species-rich frog groups, Microhylidae and Natatanura, display congruent patterns of spatial and temporal diversification among Gondwanan plates in the Late Cretaceous, long after the presumed major tectonic break-up events. Because amphibians are notoriously salt-intolerant, these analogies are best explained by simultaneous vicariance, rather than by oceanic dispersal. Hence our results imply Late Cretaceous connections between most adjacent Gondwanan landmasses, an essential concept for biogeographic and palaeomap reconstructions.

  19. Climate predictors of late quaternary extinctions

    DEFF Research Database (Denmark)

    Nogués-Bravo, David; Ohlemüller, Ralf; Batra, Persaram

    2010-01-01

    Between 50,000 and 3,000 years before present (BP) 65% of mammal genera weighing over 44 kg went extinct, together with a lower proportion of small mammals. Why species went extinct in such large numbers is hotly debated. One of the arguments proposes that climate changes underlie Late Quaternary...... extinctions, but global quantitative evidence for this hypothesis is still lacking. We test the potential role of global climate change on the extinction of mammals during the Late Quaternary. Our results suggest that continents with the highest climate footprint values, in other words, with climate changes...

  20. Toetsing van late zwangerschapsafbreking, 2004-2007

    NARCIS (Netherlands)

    Zeeman, G G; Lind, J; Verhagen, Eduard; van de Vathorst, S; Wildschut, H I J; Wolf, H

    2008-01-01

    OBJECTIVE: To provide an inventory of the reported late terminations of pregnancy because ofa severe anomaly of the unborn child, i.e. termination after 24 weeks of pregnancy, in The Netherlands for the period 2004-2007. DESIGN: Inventory and descriptive. METHOD: A description is given of the variou

  1. Shedding further light on late globalization

    DEFF Research Database (Denmark)

    Turcan, Romeo V.

    2016-01-01

    In his opening essay on ‘What and/or Who is Late’, Nikhilesh Dholakia delineated inter alia “stage-setting contexts” or levels of analysis which could shed light on the phenomenon of late globalization, including its causes and effects. Indeed, these, especially the effects in contemporary contex...

  2. Tomato late blight (Phytophthora infestans) in Uganda

    NARCIS (Netherlands)

    Tumwine, J.; Frinking, H.D.; Jeger, M.J.

    2002-01-01

    A survey on the tomato late blight situation and current practices for disease management was carried out in Uganda using an informal structured questionnaire approach. Ten districts from different agroclimatic zones were selected for the survey. Phytophthora infestans isolates from tomatoes were ob

  3. Vocabulary of Toddlers Who Are Late Talkers

    Science.gov (United States)

    MacRoy-Higgins, Michelle; Shafer, Valerie L.; Fahey, Katlin J.; Kaden, Elyssa R.

    2016-01-01

    The purpose of this study was to understand vocabulary characteristics in toddlers who are late talkers (LT) as compared with age-matched (AM) and vocabulary-matched (VM) peers. The semantic categories (e.g., animals, foods, toys) and the percentage of nouns, verbs, and closed-class words in the vocabularies of 36 toddlers (12 LT, 12 AM, 12 VM)…

  4. Fast Mapping in Late-Talking Toddlers

    Science.gov (United States)

    Weismer, Susan Ellis; Venker, Courtney E.; Evans, Julia L.; Moyle, Maura Jones

    2013-01-01

    This study investigated fast mapping in late-talking (LT) toddlers and toddlers with normal language (NL) development matched on age, nonverbal cognition, and maternal education. The fast-mapping task included novel object labels and familiar words. The LT group scored significantly lower than the NL group on novel word comprehension and…

  5. Obsessive-Compulsive Disorder in Late Life

    Science.gov (United States)

    Calamari, John E.; Pontarelli, Noelle K.; Armstrong, Kerrie M.; Salstrom, Seoka A.

    2012-01-01

    Although obsessive-compulsive disorder (OCD) has received increasing attention, the study and treatment of OCD in late life has been neglected. The obsessions and compulsions seen with older adults do not appear to differ from the symptoms experienced by other age groups, although developmental issues might influence symptom focus (e.g., memory…

  6. Cannabinoids in late-onset Alzheimer's disease

    NARCIS (Netherlands)

    Ahmed, A.; Marck, M.A. van der; Elsen, G. van den; Olde Rikkert, M.G.M.

    2015-01-01

    Given the lack of effective treatments for late-onset Alzheimer's disease (LOAD) and the substantial burden on patients, families, health care systems, and economies, finding an effective therapy is one of the highest medical priorities. The past few years have seen a growing interest in the medicin

  7. Late Immersion Foundation Document: Teachers and Administrators

    Science.gov (United States)

    Alberta Education, 2010

    2010-01-01

    The aim of this document is to give teachers and administrators the contextual and pedagogical tools for the late immersion program. It acts as a guide for beginning and experienced teachers who need to update their knowledge regarding this program and its details. For many working in this area, it also confirms their daily practices as well as…

  8. Mobile ICT Acceptance in Late Adopter Countries

    DEFF Research Database (Denmark)

    Gimpel, Gregory; Sudzina, Frantisek; Petrovcikova, Katarina

    2014-01-01

    Despite the rapid global diffusion of the smartphone, some countries have experienced much slower uptake of the technology. The low smartphone penetration within Slovakia provides the opportunity to explore what drives smartphone use in late majority countries. Slovakia is a central European nati...

  9. Language Control Abilities of Late Bilinguals

    Science.gov (United States)

    Festman, Julia

    2012-01-01

    Although all bilinguals encounter cross-language interference (CLI), some bilinguals are more susceptible to interference than others. Here, we report on language performance of late bilinguals (Russian/German) on two bilingual tasks (interview, verbal fluency), their language use and switching habits. The only between-group difference was CLI:…

  10. Nephrogenic systemic fibrosis: late skin manifestations

    DEFF Research Database (Denmark)

    Bangsgaard, Nannie; Marckmann, Peter; Rossen, Kristian

    2009-01-01

    BACKGROUND: Nephrogenic systemic fibrosis (NSF) is a serious disease that occurs in patients with severe renal disease and is believed to be caused by gadolinium-containing contrast agents. A detailed description of the late skin manifestations of NSF is important to help dermatologists and nephr......BACKGROUND: Nephrogenic systemic fibrosis (NSF) is a serious disease that occurs in patients with severe renal disease and is believed to be caused by gadolinium-containing contrast agents. A detailed description of the late skin manifestations of NSF is important to help dermatologists...... confluent dermal plaques with thickening and hardening. In contrast, 3 patients presented with wrinkled, redundant skin as seen in cutis laxa. Patients with NSF had significantly poorer scores than control patients on the Daily Life Quality Index (mean [SD], 11. 4 [7.4] vs 1.5 [2. 3]; P ...: This descriptive case series of patients with NSF gives a detailed clinical picture of the skin manifestations late in the disease. It demonstrates that the clinical picture in the late stage has a varied presentation and that NSF has a significant effect on the quality of life....

  11. Late glacial aridity in southern Rocky Mountains

    Energy Technology Data Exchange (ETDEWEB)

    Davis, O.K.; Pitblado, B.L. [Univ. of Arizona, Tucson, AZ (United States)

    1995-09-01

    While the slopes of the present-day Colorado Rocky Mountains are characterized by large stands of subalpine and montane conifers, the Rockies of the late glacial looked dramatically different. Specifically, pollen records suggest that during the late glacial, Artemisia and Gramineae predominated throughout the mountains of Colorado. At some point between 11,000 and 10,000 B.P., however, both Artemisia and grasses underwent a dramatic decline, which can be identified in virtually every pollen diagram produced for Colorado mountain sites, including Como Lake (Sangre de Cristo Mountains), Copley Lake and Splains; Gulch (near Crested Butte), Molas Lake (San Juan Mountains), and Redrock Lake (Boulder County). Moreover, the same pattern seems to hold for pollen spectra derived for areas adjacent to Colorado, including at sites in the Chuska Mountains of New Mexico and in eastern Wyoming. The implications of this consistent finding are compelling. The closest modem analogues to the Artemisia- and Gramineae-dominated late-glacial Colorado Rockies are found in the relatively arid northern Great Basin, which suggests that annual precipitation was much lower in the late-glacial southern Rocky Mountains than it was throughout the Holocene.

  12. Hypothyroidism in late-onset Pompe disease

    Directory of Open Access Journals (Sweden)

    Joseph Schneider

    2016-09-01

    Conclusions: Hypothyroidism was found at a higher prevalence in patients with late-onset Pompe disease compared to the general adult population at UMMC. Studies in larger populations of patients with Pompe disease would be needed to confirm an association of Pompe disease and hypothyroidism. Challenges include finding an adequate sample size, due the rarity of Pompe disease.

  13. Obsessive-Compulsive Disorder in Late Life

    Science.gov (United States)

    Calamari, John E.; Pontarelli, Noelle K.; Armstrong, Kerrie M.; Salstrom, Seoka A.

    2012-01-01

    Although obsessive-compulsive disorder (OCD) has received increasing attention, the study and treatment of OCD in late life has been neglected. The obsessions and compulsions seen with older adults do not appear to differ from the symptoms experienced by other age groups, although developmental issues might influence symptom focus (e.g., memory…

  14. The late maintenance of hippocampal LTP: requirements, phases, 'synaptic tagging', 'late-associativity' and implications.

    Science.gov (United States)

    Reymann, Klaus G; Frey, Julietta U

    2007-01-01

    Our review focuses on the mechanisms which enable the late maintenance of hippocampal long-term potentiation (LTP; >3h), a phenomenon which is thought to underlie prolonged memory. About 20 years ago we showed for the first time that the maintenance of LTP - like memory storage--depends on intact protein synthesis and thus, consists of at least two temporal phases. Here we concentrate on mechanisms required for the induction of the transient early-LTP and of the protein synthesis-dependent late-LTP. Our group has shown that the induction of late-LTP requires the associative activation of heterosynaptic inputs, i.e. the synergistic activation of glutamatergic and modulatory, reinforcing inputs within specific, effective time windows. The induction of late-LTP is characterized by novel, late-associative properties such as 'synaptic tagging' and 'late-associative reinforcement'. Both phenomena require the associative setting of synaptic tags as well as the availability of plasticity-related proteins (PRPs) and they are restricted to functional dendritic compartments, in general. 'Synaptic tagging' guarantees input specificity and thus the specific processing of afferent signals for the establishment of late-LTP. 'Late-associative reinforcement' describes a process where early-LTP by the co-activation of modulatory inputs can be transformed into late-LTP in activated synapses where a tag is set. Recent evidence from behavioral experiments, which studied processes of emotional and cognitive reinforcement of LTP, point to the physiological relevance of the above mechanisms during cellular and system's memory formation.

  15. Reproductive rights: Current issues of late abortion

    Directory of Open Access Journals (Sweden)

    Mujović-Zornić Hajrija

    2009-01-01

    Full Text Available This article considers the legal issues surrounding induced late abortion in cases when severe medical, therapeutic or ethical reasons have not been in dispute. Generally discussing the essential question about abortion today, it means not anymore legality of abortion but, in the first place, safety of abortion. From the aspect of woman health the most important aim is to detect and avoid possible risks of medical intervention, such as late abortion present. This is the matter of medical law context and also the matter of the woman's reproductive rights, here observed through legislation and court practice. The gynecologist has an obligation to obtain the informed consent of each patient. Information's should be presented in reasonably understandable terms and include alternative modes of treatment, objectives, risks, benefits, possible complications, and anticipated results of such treatment. Pregnant woman should receive supportive counseling before and particularly after the procedure. The method chosen for all terminations should ensure that the fetus is born dead. This should be undertaken by an appropriately trained practitioner. Reform in abortion law, making it legally accessible to woman, is not necessarily the product of a belief in woman's rights, but can be a means of bringing the practice of abortion back under better control. Counseling and good medical practice in performing late abortion are the instruments to drive this point even further home. It does not undermine the woman who wants to make a positive decision about her life and its purpose is not to produce feelings of insecurity and guilt. It concludes that existing law should not be changed but that clear rules should be devised and board created to review late term abortion. In Serbia, this leads to creation and set up guidelines for reconciling medical justification for late abortion with existing law, especially with solutions which brings comparative law. .

  16. LATE RENAL GRAFT REJECTION: PATHOLOGY AND PROGNOSIS

    Directory of Open Access Journals (Sweden)

    E.S. Stolyarevich

    2014-01-01

    Full Text Available Rejection has always been one of the most important cause of late renal graft dysfunction. Aim of the study was to analyze the prevalence of different clinico-pathological variants of rejection that cause late graft dysfunction, and evaluate their impact on long-term outcome. Materials and methods. This is a retrospective study that analyzed 294 needle core biopsy specimens from 265 renal transplant recipients with late (48,8 ± 46,1 months after transplantation allograft dysfunction caused by late acute rejection (LAR, n = 193 or chronic rejection (CR, n = 78 or both (n = 23. C4d staining was performed by immunofl uorescence (IF on frozen sections using a standard protocol. Results. Peritubular capillary C4d deposition was identifi ed in 36% samples with acute rejection and in 62% cases of chronic rejection (including 67% cases of transplant glomerulopathy, and 50% – of isolated chronic vasculopathy. 5-year graft survival for LAR vs CR vs their combination was 47, 13 and 25%, respectively. The outcome of C4d– LAR was (p < 0,01 better than of C4d+ acute rejection: at 60 months graft survival for diffuse C4d+ vs C4d− was 33% vs 53%, respectively. In cases of chronic rejection C4d+ vs C4d– it was not statistically signifi cant (34% vs 36%. Conclusion. In long-term allograft biopsy C4d positivity is more haracteristic for chronic rejection than for acute rejection. Only diffuse C4d staining affects the outcome. C4d– positivity is associated with worse allograft survival in cases of late acute rejection, but not in cases of chronic rejection. 

  17. Youth Indicators of Late-M Dwarfs

    Science.gov (United States)

    Feldman, Daniel; Cruz, K.; Lépine, S.; Alpert, N.

    2011-01-01

    We present a study in which we searched for a correlation between weak Na absorption doublet (8183Å, 8194Å) and strong H-Alpha emission (6563Å) in late-M dwarf stars (M6-M9), as both are indicative of youth. Our sample consists of late-M Dwarfs from the LSPM Survey (Lépine and Shara, 2005), which contain stars with measured proper motions of mu > 40 mas/yr. Measurements for emission and absorption strength were made using spectral indices. Our preliminary results are presented; future work will include a similar analysis of early type M Dwarfs, as well as kinematics. This work was funded by the CUNY Summer Undergraduate Research Program, as well as the CUNY Macaulay Honors College, and we acknowledge the hospitality of the American Museum of Natural History.

  18. An emerging antiarrhythmic target: late sodium current.

    Science.gov (United States)

    Banyasz, T; Szentandrássy, N; Magyar, J; Szabo, Z; Nánási, P P; Chen-Izu, Y; Izu, L T

    2015-01-01

    The cardiac late sodium current (INa,L) has been in the focus of research in the recent decade. The first reports on the sustained component of voltage activated sodium current date back to the seventies, but early studies interpreted this tiny current as a product of a few channels that fail to inactivate, having neither physiologic nor pathologic implications. Recently, the cardiac INa,L has emerged as a potentially major arrhythmogenic mechanism in various heart diseases, attracting the attention of clinicians and researchers. Research activity on INa,L has exponentially increased since Ranolazine, an FDA-approved antianginal drug was shown to successfully suppress cardiac arrhythmias by inhibiting INa,L. This review aims to summarize and discuss a series of papers focusing on the cardiac late sodium current and its regulation under physiological and pathological conditions. We will discuss critical evidences implicating INa,L as a potential target for treating myocardial dysfunction and cardiac arrhythmias.

  19. Ribbed vaults of late Gothic in Sardinia

    Directory of Open Access Journals (Sweden)

    Paola Casu

    2012-06-01

    Full Text Available The late Gothic construction practice, settled in the Spanish Mediterranean area, is based on predetermined geometric rules and is shown in religious buildings with ribbed vaults. The proportion between the sides of the area to cover, tracing plan of the ribs as a succession of corner bisectors, stereotomy problems and volumetric aspects, are just some of the elements that can describe the complex construction of a ribbed vault. The aim of this paper is to analyze the dimensional information of the late gothic ribbed vaults of Sardinia, in order to define the geometric and proportional rules for a correct drawing, establishing a standard procedure for the collection of measures and the construction of the 3D model of vaults.

  20. Educating Citizens in Late Modern Societies

    DEFF Research Database (Denmark)

    Christensen, Torben Spanget

    2011-01-01

    . The model is based on the fundamental belief that the overall aim of civic education in democratic, late modern and global societies is empowerment of the citizen in order to establish a self governing citizen who simultaneous is capable of managing and keeping together partly contradictory citizens tasks....... One is being a loyal subject in state and society affairs, a second is being an informed voter in state elections, a third is being a critical participant in state and society affairs and a forth is being an independent, innovative citizen outside state. The model is inspired by rather comprehensive......One way or the other democratic states need to take on the task of educating its rising generation in governmental affairs, societal matters and citizenship in order to sustain the democracy itself. This article presents a model for analysing civic education in late modern, globalised world...

  1. Early- versus Late-Onset Systemic Sclerosis

    Science.gov (United States)

    Alba, Marco A.; Velasco, César; Simeón, Carmen Pilar; Fonollosa, Vicent; Trapiella, Luis; Egurbide, María Victoria; Sáez, Luis; Castillo, María Jesús; Callejas, José Luis; Camps, María Teresa; Tolosa, Carles; Ríos, Juan José; Freire, Mayka; Vargas, José Antonio; Espinosa, Gerard

    2014-01-01

    Abstract Peak age at onset of systemic sclerosis (SSc) is between 20 and 50 years, although SSc is also described in both young and elderly patients. We conducted the present study to determine if age at disease onset modulates the clinical characteristics and outcome of SSc patients. The Spanish Scleroderma Study Group recruited 1037 patients with a mean follow-up of 5.2 ± 6.8 years. Based on the mean ± 1 standard deviation (SD) of age at disease onset (45 ± 15 yr) of the whole series, patients were classified into 3 groups: age ≤30 years (early onset), age between 31 and 59 years (standard onset), and age ≥60 years (late onset). We compared initial and cumulative manifestations, immunologic features, and death rates. The early-onset group included 195 patients; standard-onset group, 651; and late-onset, 191 patients. The early-onset group had a higher prevalence of esophageal involvement (72% in early-onset compared with 67% in standard-onset and 56% in late-onset; p = 0.004), and myositis (11%, 7.2%, and 2.9%, respectively; p = 0.009), but a lower prevalence of centromere antibodies (33%, 46%, and 47%, respectively; p = 0.007). In contrast, late-onset SSc was characterized by a lower prevalence of digital ulcers (54%, 41%, and 34%, respectively; p < 0.001) but higher rates of heart conduction system abnormalities (9%, 13%, and 21%, respectively; p = 0.004). Pulmonary hypertension was found in 25% of elderly patients and in 12% of the youngest patients (p = 0.010). After correction for the population effects of age and sex, standardized mortality ratio was shown to be higher in younger patients. The results of the present study confirm that age at disease onset is associated with differences in clinical presentation and outcome in SSc patients. PMID:24646463

  2. Reengineering Engineering: A Glimpse of Late Professionalism

    OpenAIRE

    Callaham, Arthur A.

    1999-01-01

    The role of the engineer in the late capitalist society of the last half century has been misunderstood at best. The lack of a consistent job description for engineers in various fields, a lack of job security, and a lack of respect from both industry and society have spawned severe angst in the engineering community. A classic remedy for this situation has been the rallying of engineering practitioners under a banner of increased professionalism. If engineers could make themselves more li...

  3. [Late primary abdominal pregnancy. Case report].

    Science.gov (United States)

    Farías, Emigdio Torres; Gómez, Luis Guillermo Torres; Allegre, René Márquez; Higareda, Salvador Hernández

    2008-09-01

    Abdominal advanced pregnancy is an obstetric complication that put at risk maternal and fetal life. We report a case of advanced abdominal pregnancy with intact ovaries and fallopian tubes, without ureteroperitoneal fistulae and, late prenatal diagnosis, in a multiparous patient without risk factors, with alive newborn, and whose pregnancy was attended at Unidad Medica de Alta Especialidad, Hospital de Gineco-Obstetricia, Centro Medico Nacional de Occidente del IMSS, Guadalajara, Jalisco, México.

  4. Late-time cosmological phase transitions

    Energy Technology Data Exchange (ETDEWEB)

    Schramm, D.N. (Chicago Univ., IL (USA) Fermi National Accelerator Lab., Batavia, IL (USA))

    1990-11-01

    It is shown that the potential galaxy formation and large-scale structure problems of objects existing at high redshifts (Z {approx gt} 5), structures existing on scales of 100M pc as well as velocity flows on such scales, and minimal microwave anisotropies ({Delta}T/T) {approx lt} 10{sup {minus}5} can be solved if the seeds needed to generate structure form in a vacuum phase transition after decoupling. It is argued that the basic physics of such a phase transition is no more exotic than that utilized in the more traditional GUT scale phase transitions, and that, just as in the GUT case, significant random gaussian fluctuations and/or topological defects can form. Scale lengths of {approximately}100M pc for large-scale structure as well as {approximately}1 M pc for galaxy formation occur naturally. Possible support for new physics that might be associated with such a late-time transition comes from the preliminary results of the SAGE solar neutrino experiment, implying neutrino flavor mixing with values similar to those required for a late-time transition. It is also noted that a see-saw model for the neutrino masses might also imply a tau neutrino mass that is an ideal hot dark matter candidate. However, in general either hot or cold dark matter can be consistent with a late-time transition. 47 refs., 2 figs.

  5. Pyomyositis of Obturator Muscles: Unusual Late Presentation

    Directory of Open Access Journals (Sweden)

    Prasad Channappa Soraganvi

    2013-04-01

    Full Text Available Introduction: Pyomyositis of obturator muscles is rare condition. Late presentation with deformities of hip misleads the clinician. Late presentation (6 weeks of this condition has not been reported earlier. This report highlights this unusual presentation of Pyomyositis of the obturator muscles. Case Report: We are reporting a 14year old female patient presented with limp and pain in hip since 6 weeks. Her hip radiographs were unremarkable. Patient was admitted and MRI done. MRI findings were consistent with obturator pyomyositis. Diagnosis of pyomyositis confirmed by MRI and we performed percutaneous aspiration and drained about 25ml of purulent material mixed with blood. The culture grew Staphylococcus aureus. Patient received intravenous antibiotic for 1week and oral antibiotic for 2weeks. Patient was immobilized in fixed skin traction in Thomas splint for 5days, later gentle mobilization was started. Her condition improved dramatically after aspiration. A follow up MRI done at 3 weeks following aspiration revealed a significant reduction in intramuscular collection of obturator internus and obturator externus. Three weeks following aspiration patient was relieved of the pain and was able to walk normally. At 6 months follow up visit patient was asymptomatic. Conclusion: Late presentation of obturator pyomyositis is rare. We emphasise on careful examination and need for early imaging for diagnosis. Percutaneous drainage results in successful treatment. Keywords: Pyomyositis, septic arthritis, infection, obturator muscle.

  6. VERY LATE PHOTOMETRY OF SN 2011fe

    Energy Technology Data Exchange (ETDEWEB)

    Kerzendorf, W. E. [Department of Astronomy and Astrophysics, University of Toronto, 50 Saint George Street, Toronto, ON M5S 3H4 (Canada); Taubenberger, S.; Seitenzahl, I. R.; Ruiter, A. J., E-mail: wkerzendorf@gmail.com [Max-Planck-Institut für Astrophysik, Karl-Schwarzschild-Straße 1, D-85748 Garching (Germany)

    2014-12-01

    The Type Ia supernova SN 2011fe is one of the closest supernovae of the past decades. Due to its proximity and low dust extinction, this object provides a very rare opportunity to study the extremely late time evolution (>900 days) of thermonuclear supernovae. In this Letter, we present our photometric data of SN 2011fe taken at an unprecedented late epoch of ≈930 days with GMOS-N mounted on the Gemini North telescope (g = 23.43 ± 0.28, r = 24.14 ± 0.14, i = 23.91 ± 0.18, and z = 23.90 ± 0.17) to study the energy production and retention in the ejecta of SN 2011fe. Together with previous measurements by other groups, our result suggests that the optical supernova light curve can still be explained by the full thermalization of the decay positrons of {sup 56}Co. This is in spite of theoretical predicted effects (e.g., infrared catastrophe, positron escape, and dust) that advocate a substantial energy redistribution and/or loss via various processes that result in a more rapid dimming at these very late epochs.

  7. Very late photometry of SN 2011fe

    CERN Document Server

    Kerzendorf, W E; Seitenzahl, I R; Ruiter, A J

    2014-01-01

    The Type Ia supernova SN 2011fe is one of the closest supernovae of the past decades. Due to its proximity and low dust extinction, this object provides a very rare opportunity to study the extremely late time evolution (> 900 d) of thermonuclear supernovae. These late stages allow for a direct measurement of the decay processes of nuclei synthesized in the core of the explosion. In this paper, we present our photometric data of SN 2011fe taken at an unprecedentedly late epoch of ~ 930 d with GMOS-N mounted on the Gemini North telescope (g=23.37+/- 0.25, r=24.03 +/- 0.09, i=23.90 +/- 0.15, and z=23.74 +/- 0.16) to study the energy production and retention in the ejecta of SN 2011fe. Together with previous measurements by other groups, our result suggests that the optical supernova light curve can still be explained by the full thermalization of the decay positrons of 56Co. This is in spite of several theoretical predictions that advocate a substantial energy redistribution and/or loss via various processes wh...

  8. Comparing Measures of Late HIV Diagnosis in Washington State

    Directory of Open Access Journals (Sweden)

    Laura Saganic

    2012-01-01

    Full Text Available As more US HIV surveillance programs routinely use late HIV diagnosis to monitor and characterize HIV testing patterns, there is an increasing need to standardize how late HIV diagnosis is measured. In this study, we compared two measures of late HIV diagnosis, one based on time between HIV and AIDS, the other based on initial CD4+ results. Using data from Washington's HIV/AIDS Reporting System, we used multivariate logistic regression to identify predictors of late HIV diagnosis. We also conducted tests for trend to determine whether the proportion of cases diagnosed late has changed over time. Both measures lead us to similar conclusions about late HIV diagnosis, suggesting that being male, older, foreign-born, or heterosexual increase the likelihood of late HIV diagnosis. Our findings reaffirm the validity of a time-based definition of late HIV diagnosis, while at the same time demonstrating the potential value of a lab-based measure.

  9. Comparing Measures of Late HIV Diagnosis in Washington State

    OpenAIRE

    Laura Saganic; Jason Carr; Rosa Solorio; Maria Courogen; Tom Jaenicke; Ann Duerr

    2011-01-01

    As more US HIV surveillance programs routinely use late HIV diagnosis to monitor and characterize HIV testing patterns, there is an increasing need to standardize how late HIV diagnosis is measured. In this study, we compared two measures of late HIV diagnosis, one based on time between HIV and AIDS, the other based on initial CD4+ results. Using data from Washington's HIV/AIDS Reporting System, we used multivariate logistic regression to identify predictors of late HIV diagnosis. We also con...

  10. Intracranial hemorrhages and late hemorrhagic disease associated cholestatic liver disease

    OpenAIRE

    2012-01-01

    Deficiency of vitamin K predisposes to early, classic or late hemorrhagic disease of the newborn (HDN); of which late HDN may be associated with serious and life-threatening intracranial hemorrhage. Late HDN is characterized intracranial bleeding in infants aged 1 week to 6 months due to severe vitamin K deficiency. Late HDN is still an important cause of mortality and morbidity in developing countries where vitamin K prophylaxis is not routinely practiced. Children with cholestatic liver dis...

  11. 7 CFR 981.481 - Interest and late payment charges.

    Science.gov (United States)

    2010-01-01

    ..., within 60 days of the invoice date. The late payment charge shall be 10 percent of the unpaid balance. ... 7 Agriculture 8 2010-01-01 2010-01-01 false Interest and late payment charges. 981.481 Section 981... GROWN IN CALIFORNIA Administrative Rules and Regulations § 981.481 Interest and late payment charges. (a...

  12. Late-presenting congenital diaphragmatic hernia

    Directory of Open Access Journals (Sweden)

    Raashid Hamid

    2014-01-01

    Full Text Available Background: This study was undertaken to highlight the clinical profile, misdiagnosis, surgical treatment,and prognosis of late-presenting congenital diaphragmatic hernia (CDH cases in a tertiary level hospital. Patients and Methods: This retrospective study included all the babies and children >1 month of age with CDH who were admitted in our Hospital (Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India during the period between January 2008 and December 2013. Babies with age <1 month were excluded from the study. Data regarding clinical profile, operative records, and follow-up was reviewed and analysed statistically. Results: A total of 20 patients were included in this study. The clinical picture ranged from respiratory distress (13 patients to non-specific gastrointestinal complaints (5 patients. In two patients, CDH was misdiagnosed as pneumothorax and had got chest tube inserted in other hospitals before referral to this tertiary care centre. In 14 patients chest, X-ray revealed the diagnosis of CDH and in remaining five patients (including the two patients with misdiagnosis further investigations were undertaken to establish the diagnosis. Age ranged from 45 days to 17 years with an average age of 58.9 months. There were 12 male and 8 female patients. In all the 20 patients, surgical procedures were undertaken with the retrieval of herniated contents from the thoracic cavity and repair of the diaphragmatic defect. There was no mortality in our series. All the 20 patients were followed-up for a period ranging from 6 months to 5 years (median 3.1 years. Conclusions: Late-presenting CDH can have diverse clinical presentation. Late diagnosis and misdiagnosis can result in significant morbidity and potential mortality if these cases are not managed properly at an appropriate stage. Outcome is favourable if these patients are expeditiously identified and surgically repaired.

  13. Technical bases DWPF Late Washing Facility

    Energy Technology Data Exchange (ETDEWEB)

    Fish, D.L.; Landon, L.F.

    1992-08-10

    A task force recommended that the technical feasibility of a Late Wash' facility be assessed [1]. In this facility, each batch of tetraphenylborate slurry from Tank 49 would be given a final wash to reduce the concentrations of nitrite and radiolysis products to acceptable levels. Laboratory-scale studies have demonstrated that d the nitrite content of the slurry fed to DWPF is reduced to 0.01 M or less (and at least a 4X reduction in concentration of the soluble species is attained), (1) the need for HAN during hydrolysis is eliminated (eliminating the production of ammonium ion during hydrolysis), (2) hydrolysis may be done with a catalyst concentration that will not exceed the copper solubility in glass and (3) the non-polar organic production during hydrolysis is significantly reduced. The first phase of an aggressive research and development program has been completed and all test results obtained to date support the technical feasibility of Late Washing. Paralleling this research and development effort is an aggressive design study directed by DWPF to scope and cost retrofitting the Auxiliary Pump Pit (APP) to enable performing a final wash of each batch of precipitate slurry before R is transferred into the DWPF Soft Processing Cell (SPC). An initial technical bases for the Late Wash Facility was transmitted to DWPF on June 15, 1992. Research and development activities are continuing directed principally at optimization of the cross-f low fitter decontamination methodology and pilot-scale validation of the recommended benzene stripping metodology.

  14. Assessing Fatigue in Late-Midlife

    DEFF Research Database (Denmark)

    Fieo, Robert A; Mortensen, Erik Lykke; Lund, Rikke

    2014-01-01

    late-midlife subjects. Five subdimensions of perceived fatigue were examined in n = 7,233 subjects: general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue. Fatigue burden was compared across age groups (aged 48-52 vs. 57-63) and gender. Mokken item response theory...... was used to investigate dimensionality, monotonicity, and invariant item ordering (IIO). In both age groups, as well as by gender, the Motivation domain presented with weak scalability, suggesting that caution be exercised when interpreting sum scores. For all groupings, the strongest scaling properties...

  15. Late-stage sinking of plutons

    Science.gov (United States)

    Glazner, A.F.; Miller, D.M.

    1997-01-01

    Many granodiorite to diorite plutons in the Great Basin of western North America are surrounded by rim monoclines or anticlines that suggest relative downward movement of the plutons while wall rocks were hot and ductile. We propose that such plutons rise to a level of approximately neutral buoyancy and then founder as their densities increase ??? 40% during crystallization. Late-stage sinking of intermediate to mafic plutons should be common when wall rocks are rich in weak, low-density minerals such as quartz and calcite. Structures related to sinking will overprint those related to initial pluton emplacement and may be mistaken for regional tectonic structures.

  16. Public Schools in Australia from the Late 1970s to the Late 1980s: The Seeds of Change

    Science.gov (United States)

    Barcan, Alan

    2010-01-01

    The period from the late 1970s to the late 1980s were transition years for most public(government) school systems in Australia. A reaction was developing against the neo-progressive and radical (neo-Marxist) innovations of the late 1960s and 1970s such as school-based curricula, activity methods, and "open education". By the early 1980s the…

  17. Cross-sectional analysis of late HAART initiation in Latin America and the Caribbean: late testers and late presenters.

    Directory of Open Access Journals (Sweden)

    Brenda Crabtree-Ramírez

    Full Text Available BACKGROUND: Starting HAART in a very advanced stage of disease is assumed to be the most prevalent form of initiation in HIV-infected subjects in developing countries. Data from Latin America and the Caribbean is still lacking. Our main objective was to determine the frequency, risk factors and trends in time for being late HAART initiator (LHI in this region. METHODOLOGY: Cross-sectional analysis from 9817 HIV-infected treatment-naïve patients initiating HAART at 6 sites (Argentina, Chile, Haiti, Honduras, Peru and Mexico from October 1999 to July 2010. LHI had CD4(+ count ≤200 cells/mm(3 prior to HAART. Late testers (LT were those LHI who initiated HAART within 6 months of HIV diagnosis. Late presenters (LP initiated after 6 months of diagnosis. Prevalence, risk factors and trends over time were analyzed. PRINCIPAL FINDINGS: Among subjects starting HAART (n = 9817 who had baseline CD4(+ available (n = 8515, 76% were LHI: Argentina (56%[95%CI:52-59], Chile (80%[95%CI:77-82], Haiti (76%[95%CI:74-77], Honduras (91%[95%CI:87-94], Mexico (79%[95%CI:75-83], Peru (86%[95%CI:84-88]. The proportion of LHI statistically changed over time (except in Honduras (p≤0.02; Honduras p = 0.7, with a tendency towards lower rates in recent years. Males had increased risk of LHI in Chile, Haiti, Peru, and in the combined site analyses (CSA. Older patients were more likely LHI in Argentina and Peru (OR 1.21 per +10-year of age, 95%CI:1.02-1.45; OR 1.20, 95%CI:1.02-1.43; respectively, but not in CSA (OR 1.07, 95%CI:0.94-1.21. Higher education was associated with decreased risk for LHI in Chile (OR 0.92 per +1-year of education, 95%CI:0.87-0.98 (similar trends in Mexico, Peru, and CSA. LHI with date of HIV-diagnosis available, 55% were LT and 45% LP. CONCLUSION: LHI was highly prevalent in CCASAnet sites, mostly due to LT; the main risk factors associated were being male and older age. Earlier HIV-diagnosis and earlier treatment initiation are needed

  18. Can Mustard Gas Induce Late Onset Polyneuropathy?

    Directory of Open Access Journals (Sweden)

    SJ. Mousavi

    2007-11-01

    Full Text Available Background:Mustard gas, lethal in high doses, affects multiple organs such as skin, eye and respiratory system. We studied the development of late onset mustardinduced polyneuropathy among chemically wounded Iranian veterans.Methods:In this descriptive study,100 chemically wounded Iranian veterans with severe eye involvement were examined for any signs and symptoms of polyneuropathy by an internist.20 patients were suspected to have neurological symptoms or signs.These patients were examined by a neurologist again. 13 showed abnormal neurological symptoms. Electrodiagnostic exams were performed for this group by another physician.Results:13 veterans had abnormal neurological exam results with prominent sensory signs and symptoms in almost all of them. Brisk deep tendon reflexes were found in 3 cases. Electrodiagnostic studies were compatible with axonal type distal sensory polyneuropathy in 6 subjects. Conclusion: To the best of our knowledge, this is the first report of late onset polyneuropathy among chemically-wounded victims who were exposed to mustard gas. The pathophysiology of this form of neuropathy is still unknown. Unlike most toxic neuropathies,obvious clinical signs and symptoms appeared several years after exposure. No specific treatment for.polyneuropathy due to chemical weapons exposure has been described to date.

  19. Why does schizophrenia develop at late adolescence?

    Science.gov (United States)

    Harrop, C; Trower, P

    2001-03-01

    Schizophrenia is one of the most researched, yet still one of the least understood, of the mental disorders. One key area that remains comparatively neglected is the fact that schizophrenia typically develops at late adolescence. In common with people with psychotic disorders, around 25% of normal teenagers also report finding adolescence very distressing, and a substantial empirical literature shows that certain characteristics typical of adolescence such as conflicted family relationships, grandiosity, egocentrism, and magical ideation bear a distinct resemblance to phenomena seen in psychotic disorders. Indeed, such phenomena, as might be judged prodromal or symptomatic in first-onset schizophrenia, have been shown to be remarkably common in normal adolescents, generally in about 50% of samples. Furthermore, prodromal-like signs in normal adolescents appear to be functionally linked to psychological development. For most adolescents, such phenomena pass with successful psychological development. It is proposed that psychosis in late adolescence is a consequence of severe disruption in this normally difficult psychological maturational process in vulnerable individuals, and explanations are offered as to why and how this comes about. It is suggested that problems either in reaching psychological maturity with regard to parents or in bonding to peers or both, may lead to crucial self-construction difficulties, and that psychosis emerges out of such "blocked adolescence." This approach proposes therapeutic interventions that enable professional services to side with both parents and clients simultaneously, and is normalizing and stigma-free.

  20. Late Quaternary climate change shapes island biodiversity.

    Science.gov (United States)

    Weigelt, Patrick; Steinbauer, Manuel Jonas; Cabral, Juliano Sarmento; Kreft, Holger

    2016-04-07

    Island biogeographical models consider islands either as geologically static with biodiversity resulting from ecologically neutral immigration-extinction dynamics, or as geologically dynamic with biodiversity resulting from immigration-speciation-extinction dynamics influenced by changes in island characteristics over millions of years. Present climate and spatial arrangement of islands, however, are rather exceptional compared to most of the Late Quaternary, which is characterized by recurrent cooler and drier glacial periods. These climatic oscillations over short geological timescales strongly affected sea levels and caused massive changes in island area, isolation and connectivity, orders of magnitude faster than the geological processes of island formation, subsidence and erosion considered in island theory. Consequences of these oscillations for present biodiversity remain unassessed. Here we analyse the effects of present and Last Glacial Maximum (LGM) island area, isolation, elevation and climate on key components of angiosperm diversity on islands worldwide. We find that post-LGM changes in island characteristics, especially in area, have left a strong imprint on present diversity of endemic species. Specifically, the number and proportion of endemic species today is significantly higher on islands that were larger during the LGM. Native species richness, in turn, is mostly determined by present island characteristics. We conclude that an appreciation of Late Quaternary environmental change is essential to understand patterns of island endemism and its underlying evolutionary dynamics.

  1. Midlife migraine and late-life parkinsonism

    Science.gov (United States)

    Ross, G. Webster; Sigurdsson, Sigurdur; Garcia, Melissa; Gudmundsson, Larus S.; Sveinbjörnsdóttir, Sigurlaug; Wagner, Amy K.; Gudnason, Vilmundur; Launer, Lenore J.

    2014-01-01

    Objective: In the present study, we tested the hypothesis that having migraine in middle age is related to late-life parkinsonism and a related disorder, restless legs syndrome (RLS), also known as Willis-Ekbom disease (WED). Methods: The AGES-Reykjavik cohort (born 1907–1935) has been followed since 1967. Headaches were classified based on symptoms assessed in middle age. From 2002 to 2006, 5,764 participants were reexamined to assess symptoms of parkinsonism, diagnosis of Parkinson disease (PD), family history of PD, and RLS/WED. Results: Subjects with midlife migraine, particularly migraine with aura (MA), were in later life more likely than others to report parkinsonian symptoms (odds ratio [OR]MA = 3.6 [95% CI 2.7–4.8]) and diagnosed PD (ORMA = 2.5 [95% CI 1.2–5.2]). Women with MA were more likely than others to have a parent (ORMA = 2.26 [95% CI 1.3–4.0]) or sibling (ORMA = 1.78 [95% CI 1.1–2.9]) with PD. Late-life RLS/WED was increased for headache generally. Associations were independent of cardiovascular disease and MRI-evident presumed ischemic lesions. Conclusions: These findings suggest there may be a common vulnerability to, or consequences of, migraine and multiple indicators of parkinsonism. Additional genetic and longitudinal observational studies are needed to identify candidate pathways that may account for the comorbid constellation of symptoms. PMID:25230997

  2. Late Paravalvular Aortic Regurgitation: Migration of the Valve or Late Recoil?

    Science.gov (United States)

    Karimi, Ashkan; Pourafshar, Negiin; Park, Ki E; Choi, Calvin Y; Mogali, Kiran; Stinson, Wade W; Manning, Eddie W; Bavry, Anthony A

    2017-01-02

    A 79-year-old man underwent trans-catheter aortic valve replacement for symptomatic severe aortic stenosis with a 26-mm Edwards SAPIEN XT valve. Immediately after valve deployment there was moderate amount of paravalvular leak. Post-dilation was performed with an additional 2 cc of volume, and the paravalvular leak was reduced to trace. Nine months later, trans-thoracic echocardiography revealed moderate to severe paravalvular leak and possible aortic migration of the valve. The patient was brought back for the treatment of the paravalvular leak which was suspected to be due to valve migration. However, fluoroscopy and trans-esophageal echocardiography showed good valve position. Measurement of late valve recoil in the Coplanar view using cine-angiographic analysis software showed that the lower third of the valve had the greatest late recoil (-1.74 mm, 6.55%), which presumably accounted for the progression of the paravalvular leak. Valve-in-valve trans-catheter aortic valve replacement was performed with a 26-mm SAPIEN 3 valve and the paravalvular leak was reduced to trace. This case displays late recoil as a likely mechanism for development of paravalvular leak after SAPIEN XT valve implantation. Our case illustrates that late recoil needs to be systematically evaluated in future studies, especially when trans-catheter aortic valve replacement is being expanded to lower risk and younger patients for whom the longevity and long-term performance of these valves is of critical importance.

  3. Sedimentary architecture and chronostratigraphy of a late Quaternary incised-valley fill : A case study of the late Middle and Late Pleistocene Rhine system in the Netherlands

    NARCIS (Netherlands)

    Peeters, J.; Busschers, F. S.; Stouthamer, E.; Bosch, J. H A; Van den Berg, M. W.; Wallinga, J.; Versendaal, A. J.; Bunnik, F. P M; Middelkoop, H.

    2016-01-01

    This paper describes the sedimentary architecture, chronostratigraphy and palaeogeography of the late Middle and Late Pleistocene (Marine Isotope Stage/MIS 6-2) incised Rhine-valley fill in the central Netherlands based on six geological transects, luminescence dating, biostratigraphical data and a

  4. Late removal of retrievable caval filters.

    Science.gov (United States)

    von Segesser, Ludwig K; Ferrari, Enrico; Tozzi, Piergiorgio; Abdel-Sayed, Saad; Berdajs, Denis

    2014-01-01

    The advent of retrievable caval filters was a game changer in the sense, that the previously irreversible act of implanting a medical device into the main venous blood stream of the body requiring careful evaluation of the pros and cons prior to execution suddenly became a "reversible" procedure where potential hazards in the late future of the patient lost most of their weight at the time of decision making. This review was designed to assess the rate of success with late retrieval of so called retrievable caval filters in order to get some indication about reasonable implant duration with respect to relatively "easy" implant removal with conventional means, i.e., catheters, hooks and lassos. A PubMed search (www.pubmed.gov) was performed with the search term "cava filter retrieval after 30 days clinical", and 20 reports between 1994 and 2013 dealing with late retrieval of caval filters were identified, covering approximately 7,000 devices with 600 removed filters. The maximal duration of implant reported is 2,599 days and the maximal implant duration of removed filters is also 2,599 days. The maximal duration reported with standard retrieval techniques, i.e., catheter, hook and/or lasso, is 475 days, whereas for the retrievals after this period more sophisticated techniques including lasers, etc. were required. The maximal implant duration for series with 100% retrieval accounts for 84 days, which is equivalent to 12 weeks or almost 3 months. We conclude that retrievable caval filters often become permanent despite the initial decision of temporary use. However, such "forgotten" retrievable devices can still be removed with a great chance of success up to three months after implantation. Conventional percutaneous removal techniques may be sufficient up to sixteen months after implantation whereas more sophisticated catheter techniques have been shown to be successful up to 83 months or more than seven years of implant duration. Tilting, migrating, or misplaced

  5. Late ulnar paralysis. Study of seventeen cases.

    Science.gov (United States)

    Mansat, M; Bonnevialle, P; Fine, X; Guiraud, B; Testut, M F

    1983-01-01

    Seventeen cases of late ulnar paralysis treated by neurolysis-transposition are reported. The clinical characteristics of these paralysis are emphasized. A very prolonged symptom free interval, a rapid onset and a severe involvement. The ulnar transposition was most often done subcutaneously. Cubitus valgus and definite nerve compression proximal to the arcade of the flexor carpi ulnaris muscle are almost always present. The results as regards the neuropathy are notable: no patient is completely cured and only half are improved. An anatomical study of the nerve path shows the essential role, in the compression of the nerve, of the muscular arcade of the flexor carpi ulnaris muscle which acts in a way similar to the bridge of a violin. Hence, opening it longitudinally is the principal procedure of the neurolysis. This should be routine before the first signs of neuropathy occur in an elbow whose axis is out of alignment as a sequela of a childhood injury.

  6. Pachyonychia congenita with late onset (PC tarda

    Directory of Open Access Journals (Sweden)

    A Sravanthi

    2016-01-01

    Full Text Available Pachyonychia congenita is a rare type of ectodermal dysplasia further classified into 4 types. Cutaneous manifestations seen in most of the cases of Pachyonychia congenita include palmoplantar keratoderma, follicular hyperkeratosis, wedge shaped nails, oral leukokeratosis and woolly hair. A 25-year-old male presented to us with thickened nails and scanty scalp hair. On examination, we noticed hyperkeratotic plaques over both the soles, palmoplantar hyperhidrosis and yellowish discoloration, wedging with subungual hyperkeratosis of all the nails. Follicular hyperkeratotic papules and steatocystoma multiplex were also observed over the scalp and face. The patient had history of natal teeth and on dental examination, lower central incisors were absent. All cutaneous changes in our case had manifested first in the 2nd decade except for natal teeth. All the above features suggested the diagnosis of pachyonychia congenita with late onset (PC tarda, which is an infrequently reported rare variant.

  7. Systematic ranging and late warning asteroid impacts

    CERN Document Server

    Farnocchia, D; Micheli, M

    2015-01-01

    We describe systematic ranging, an orbit determination technique especially suitable to assess the near-term Earth impact hazard posed by newly discovered asteroids. For these late warning cases, the time interval covered by the observations is generally short, perhaps a few hours or even less, which leads to severe degeneracies in the orbit estimation process. The systematic ranging approach gets around these degeneracies by performing a raster scan in the poorly-constrained space of topocentric range and range rate, while the plane of sky position and motion are directly tied to the recorded observations. This scan allows us to identify regions corresponding to collision solutions, as well as potential impact times and locations. From the probability distribution of the observation errors, we obtain a probability distribution in the orbital space and then estimate the probability of an Earth impact. We show how this technique is effective for a number of examples, including 2008 TC3 and 2014 AA, the only tw...

  8. Phylogenetic paleobiogeography of Late Ordovician Laurentian brachiopods

    Directory of Open Access Journals (Sweden)

    Jennifer E. Bauer

    2014-12-01

    Full Text Available Phylogenetic biogeographic analysis of four brachiopod genera was used to uncover large-scale geologic drivers of Late Ordovician biogeographic differentiation in Laurentia. Previously generated phylogenetic hypotheses were converted into area cladograms, ancestral geographic ranges were optimized and speciation events characterized as via dispersal or vicariance, when possible. Area relationships were reconstructed using Lieberman-modified Brooks Parsimony Analysis. The resulting area cladograms indicate tectonic and oceanographic changes were the primary geologic drivers of biogeographic patterns within the focal taxa. The Taconic tectophase contributed to the separation of the Appalachian and Central basins as well as the two midcontinent basins, whereas sea level rise following the Boda Event promoted interbasinal dispersal. Three migration pathways into the Cincinnati Basin were recognized, which supports the multiple pathway hypothesis for the Richmondian Invasion.

  9. Late presentation for HIV care across Europe

    DEFF Research Database (Denmark)

    Mocroft, Amanda; Lundgren, Jens; Antinori, Andrea

    2015-01-01

    Late presentation (LP) for HIV care across Europe remains a significant issue. We provide a cross-European update from 34 countries on the prevalence and risk factors of LP for 2010-2013. People aged ≥ 16 presenting for HIV care (earliest of HIV-diagnosis, first clinic visit or cohort enrollment......) after 1 January 2010 with available CD4 count within six months of presentation were included. LP was defined as presentation with a CD4 count HIV diagnosis. Logistic regression investigated changes in LP over time. A total.......02-1.32), and a significant decline in LP in northern Europe (aOR/year later 0.89; 95% CI: 0.85-0.94). Further improvements in effective HIV testing strategies, with a focus on vulnerable groups, are required across the European continent....

  10. Kynanthropy: canine madness in Byzantine late antiquity.

    Science.gov (United States)

    Metzger, Nadine

    2015-09-01

    Those afflicted bark like dogs, scramble on all fours and loiter around graveyards - canine madness, referred to as kynanthropy, was an illness concept in its own right in the medicine of late antiquity. At roughly the same time as the medical description produced by Aëtius of Amida, the Syrian chronicler John of Ephesus, also from Amida, reported an epidemic of dog-like madness sweeping his home town in ad 560. The symptoms are identical and both authors are from Amida - what is the connection between the two depictions? In addition to the history of the medical concept, the example of the canine madness of Amida and its cultural embedding allows us to contextualize and interpret the significance of dog-like behaviour for the people of the sixth century AD. © The Author(s) 2015.

  11. LATE CARBONIFEROUS BRACHIOPODS FROM KARAKORUM, PAKISTAN

    Directory of Open Access Journals (Sweden)

    LUCIA ANGIOLINI

    1999-03-01

    Full Text Available Carboniferous rocks from North Karakorum display sharp lateral variations in lithology and thickness suggesting accumulation in half-grabens during continental rifting between the Karakorum block and northern Gondwana. Different Carboniferous successions, belonging to distinct tectonic units, have been detected. Thin, poorly fossiliferous successions of arenites and crinoidal limestones contrast with very thick terrigenous-carbonate successions comprising two distinct fossiliferous horizons. The lower fossiliferous horizon yielded brachiopods (Pustula sp., Rhipidomella sp., Choristites sp., Martiniopsis sp., Afghanospirifer sp., Gypospirifer sp., Composita sp. of Bashkirian age. The upper fossiliferous horizon, lying about 90 m above the former, contains corals, crinoids and brachiopods (Densepustula cf. losarensis, Dowhatania sulcata n. sp., Brachythyris sp., Rhipidomella sp., Septacamera dowhatensis, Alispirifer middlemissi of Moscovian to Kasimovian age. The Carboniferous brachiopods of North Karakorum are similar to those collected in the Late Carboniferous of Central Afghanistan, Himalaya (Manang, Spiti, Tibet, and Lhasa Block (Xainza area. 

  12. New Modernist Studies and Late Modernism

    Directory of Open Access Journals (Sweden)

    Eliza Kącka

    2014-01-01

    Full Text Available studies into late modernism—of the issues which are worth researchingor the problems which should be signalled. The article starts witha recognition of a poor presence of the category of modernism in thinkingabout the literature of the 20th and 21st centuries and submits severalproposals. At the beginning, a proposal of confronting a modernistparadigm with a paradigm of Romantic revision. This proposal was presentedwith an awareness of the fuzziness of the notion of modernism aswell as the notion of Romantic revision in Polish academic environment.The following research postulates that would be formulated are: deeperreflection on the language (in connection with tradition, heritage andtheir problematization and on the practices of reading. Later, the textposes a question about the way of studying the permeation of discoursesin the writing of specific representatives of modernism and demandsgreater recognition for the Central European perspective in research.

  13. Possible impact event in the Late Cambrian

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The repeated investigation of the Batyrbay section has been done by the authors. Today we see increasing of interest to revising of volumes and boundaries of Stages and Series in the Cambrian and Ordovician,as well as to the events of this time. In this work the description of iron spherules and particles, found in the deep-water limestone layer of the conodont Cordylodus primitivus Zone in the middle Upper Cambrian of the Batyrbay section, Malyi Karatau of South Kazakhstan, and formed during the time of global sea-level changes known as a world-wide Lange Ranch Eustatic event, have been done. From our point of view, finds of iron spherules and particles may evidence about new unknown yet Event of cosmic origin, i.e. falling of a meteorite on Earth in the middle Late Cambrian.

  14. Spectroscopy of late type giant stars

    Science.gov (United States)

    Spaenhauer, A.; Thevenin, F.

    1984-06-01

    An attempt to calibrate broadband RGU colors of late type giant stars in terms of the physical parameters of the objects is reported. The parameters comprise the effective temperature, surface gravity and global metal abundance with respect to the sun. A selection of 21 giant star candidates in the Basel fields Plaut 1, Centaurus III and near HD 95540 were examined to obtain a two color plot. Attention is focused on the G-R color range 1.5-2.15 mag, i.e., spectral types K0-K5. A relationship between R and the metallicity is quantified and shown to have a correlation coefficient of 0.93. No correlation is found between metallicity and gravity or R and the effective temperature.

  15. Late evening artificial insemination of turkey hens.

    Science.gov (United States)

    Nestor, K E; Renner, P A

    1982-12-01

    Turkey hens were artificially inseminated at three times (0800, 1100, or 2200 hr) under conditions where high or low fertility would be expected. Four trials were conducted and the same two persons collected semen and inseminated the hens in all trials. Each hen was inseminated with .025 cc undiluted semen. There was no significant difference in fertility when hens were inseminated at different times of the day in the first three trials. In a fourth trial, where high fertility was expected, hens inseminated at 0800 hr had lower fertility than those inseminated at 2200 hr. There was no significant difference between inseminating at 0800 or 1100 hr and 1100 or 2200 hr. The results of this study indicate that late evening insemination is not necessary for high fertility.

  16. Early and Late Rate of Force Development

    DEFF Research Database (Denmark)

    Andersen, Lars L; Andersen, Jesper L; Zebis, Mette K

    2010-01-01

    The objective of this study is to investigate the potentially opposing influence of qualitative and quantitative muscular adaptations in response to high-intensity resistance training on contractile rate of force development (RFD) in the early (200 ms) of rising muscle force. Fifteen healthy young...... the vastus lateralis. The main findings were that RFD in the late phase of rising muscle force increased in response to resistance training whereas early RFD remained unchanged and early relative RFD (i.e., RFD/MVC) decreased. Quantitatively, muscle fiber cross-sectional area and MVC increased whereas......-intensity resistance training due to differential influences of qualitative and quantitative muscular adaptations on early and later phases of rising muscle force....

  17. Electronic entanglement in late transition metal oxides.

    Science.gov (United States)

    Thunström, Patrik; Di Marco, Igor; Eriksson, Olle

    2012-11-01

    We present a study of the entanglement in the electronic structure of the late transition metal monoxides--MnO, FeO, CoO, and NiO--obtained by means of density-functional theory in the local density approximation combined with dynamical mean-field theory. The impurity problem is solved through exact diagonalization, which grants full access to the thermally mixed many-body ground state density operator. The quality of the electronic structure is affirmed through a direct comparison between the calculated electronic excitation spectrum and photoemission experiments. Our treatment allows for a quantitative investigation of the entanglement in the electronic structure. Two main sources of entanglement are explicitly resolved through the use of a fidelity based geometrical entanglement measure, and additional information is gained from a complementary entropic entanglement measure. We show that the interplay of crystal field effects and Coulomb interaction causes the entanglement in CoO to take a particularly intricate form.

  18. [Treatability of sporadic late onset nemaline myopathy].

    Science.gov (United States)

    Hanisch, F; Schneider, I; Müller, T; Romeike, B F; Stoltenburg, G; Holzhausen, H J; Zierz, S

    2013-08-01

    Sporadic late onset nemaline myopathy (SLONM) is an extremely rare disorder which can be associated with monoclonal gammopathy of unclear significance (MGUS). Clinically SLONM appears mostly after the fourth decade of life as rapidly progressing tetraparesis, respiratory insufficiency and features, such as dropped head syndrome, facial and bulbar involvement. Diagnosis is confirmed by muscle biopsy with detection of nemaline bodies and also frequently lobulated fibres. Immunosuppressant and immunomodulating therapies have been shown to be ineffective but clinical improvement accompanied by disappearance of monoclonal gammopathy and even nemaline bodies was reported following autologous stem cell transplantation and chemotherapy with melphalan. This article presents the case of a 53-year-old man with a 4-year history of SLOMN with MGUS in which administration of intravenous immunoglobulin therapy (IVIG) was not successful in reversing gammopathy, histopathological changes or clinical symptoms.

  19. Late Termination of Pregnancy. Professional Dilemmas

    Directory of Open Access Journals (Sweden)

    Isack Kandel

    2003-01-01

    Full Text Available Abortion is an issue as long as history and hotly debated in all societies and communities. In some societies and countries it is legal, while other countries have no legal basis, and some countries have made it a crime. Today up to 90% of abortions take place in the first trimester, about 9% in the second trimester, and the rest in the third trimester.This paper deals with the issue of late termination of pregnancy, the practical medical aspects, legal issues, international aspects, and the dilemma for the professional.In early history, abortion was accepted by clergy and societies, but in recent history it is more restricted and in some countries prohibited. It does not seem that restriction leads to a lower abortion rate, but rather an active contraceptive policy, campaign, and availability to prevent pregnancies that are unwanted. In countries where abortion is restricted, the trend has been an increase in illegal abortion that leads to unsafe abortion with complications, permanent injuries, and maternal mortality.Unsafe and illegal abortion is a public health concern that governments should try to prevent and instead find ways to strengthen their commitments toward better and safer health and family planning services for women.Late termination of pregnancies is an issue of grave concern with many practical medical aspects, ethical questions, and professional dilemmas. This is especially of concern because of the viability of the fetus and should only take place in order to prevent harm to the physical and mental health of the mother or due to an anomaly or disability of the fetus.

  20. Late termination of pregnancy. Professional dilemmas.

    Science.gov (United States)

    Kandel, Isack; Merrick, Joav

    2003-09-23

    Abortion is an issue as long as history and hotly debated in all societies and communities. In some societies and countries it is legal, while other countries have no legal basis, and some countries have made it a crime. Today up to 90% of abortions take place in the first trimester, about 9% in the second trimester, and the rest in the third trimester. This paper deals with the issue of late termination of pregnancy, the practical medical aspects, legal issues, international aspects, and the dilemma for the professional. In early history, abortion was accepted by clergy and societies, but in recent history it is more restricted and in some countries prohibited. It does not seem that restriction leads to a lower abortion rate, but rather an active contraceptive policy, campaign, and availability to prevent pregnancies that are unwanted. In countries where abortion is restricted, the trend has been an increase in illegal abortion that leads to unsafe abortion with complications, permanent injuries, and maternal mortality. Unsafe and illegal abortion is a public health concern that governments should try to prevent and instead find ways to strengthen their commitments toward better and safer health and family planning services for women. Late termination of pregnancies is an issue of grave concern with many practical medical aspects, ethical questions, and professional dilemmas. This is especially of concern because of the viability of the fetus and should only take place in order to prevent harm to the physical and mental health of the mother or due to an anomaly or disability of the fetus.

  1. Plate tectonics in the late Paleozoic

    Directory of Open Access Journals (Sweden)

    Mathew Domeier

    2014-05-01

    Full Text Available As the chronicle of plate motions through time, paleogeography is fundamental to our understanding of plate tectonics and its role in shaping the geology of the present-day. To properly appreciate the history of tectonics—and its influence on the deep Earth and climate—it is imperative to seek an accurate and global model of paleogeography. However, owing to the incessant loss of oceanic lithosphere through subduction, the paleogeographic reconstruction of ‘full-plates’ (including oceanic lithosphere becomes increasingly challenging with age. Prior to 150 Ma ∼60% of the lithosphere is missing and reconstructions are developed without explicit regard for oceanic lithosphere or plate tectonic principles; in effect, reflecting the earlier mobilistic paradigm of continental drift. Although these ‘continental’ reconstructions have been immensely useful, the next-generation of mantle models requires global plate kinematic descriptions with full-plate reconstructions. Moreover, in disregarding (or only loosely applying plate tectonic rules, continental reconstructions fail to take advantage of a wealth of additional information in the form of practical constraints. Following a series of new developments, both in geodynamic theory and analytical tools, it is now feasible to construct full-plate models that lend themselves to testing by the wider Earth-science community. Such a model is presented here for the late Paleozoic (410–250 Ma together with a review of the underlying data. Although we expect this model to be particularly useful for numerical mantle modeling, we hope that it will also serve as a general framework for understanding late Paleozoic tectonics, one on which future improvements can be built and further tested.

  2. Late-glacial of southern South America

    Science.gov (United States)

    Heusser, C. J.

    Overall trends in late-glacial paleoenvironments of southern South America are interpretable from the pollen stratigraphy of radiocarbon dated sections of mires in Tierra del Fuego (55°S), the Chilotan archipelago (42-43°S), and the Chilean Lake District (39-41°S). In Tierra del Fuego, southern beech ( Nothofagus) and shrub and herb taxa (Gramineae, Empetrum, Acaena, Gunnera, Compositae and Cyperaceae) serve as indicators of the changing climate; in the Chilotan archipelago and in the Chilean Lake District, southern beech and other trees (species of Myrtaceae, Podocarpus, Prumnopitys, Pseudopanax and Weinmannia) suffice as indices of climatic change. Pollen records from each of these regions, although in need of greater dating control, indicate climatic sequences that are broadly similar. The records, however, are not regionally consistent in all aspects and differ in their indicator value with the implication of fossil beetle evidence. Attempts at correlation can be unsatisfactory at times and can stem inter alia from the different ecophysiological responses of both plants and beetles to environmental pressures. These differences, which affect the timing of reproduction and migration, may result in the variable occurrence of different species in the records. The broad implication of the pollen data is that following a glacial readvance culminating at about 15,000-14,500 BP, late-glacial climate was generally warmer during intervals before 13,000 and between 12,000 and 11,000 BP, and was cooler between 13,000 and 12,000 and from 11,000 to 10,000 BP.

  3. Neuropsychological functioning in late-life depression

    Directory of Open Access Journals (Sweden)

    Gro Strømnes Dybedal

    2013-06-01

    Full Text Available Background: The literature describing neurocognitive function in patients with late-life depression (LLD show inconsistent findings in regard to incidence and main deficits. Reduced information processing speed is in some studies found to explain deficits in higher order cognitive function, while other studies report specific deficits in memory and executive function. Our aim was to determine the characteristics of neuropsychological functioning in non-demented LLD patients.Methods; A comprehensive neuropsychological battery was administered to a group of hospitalized LLD patients and healthy control subjects. Thirty-nine patients without dementia, 60 years or older meeting DSM-IV criteria for current episode of major depression, and 18 nondepressed control subjects were included. The patient group was characterized by having a long lasting current depressive episode of late-onset depression and by being non-responders to treatment with antidepressants. Neurocognitive scores were calculated for the domains of information processing speed, verbal memory, visuospatial memory, executive function, and language. Number of impairments (performance below the 10th percentile of the control group per domain for each participant was calculated. Results: Nearly half of the patients had a clinically significant cognitive impairment in at least one neurocognitive domain. Relative to healthy control subjects, LLD patients performed significantly poorer in the domains of information processing speed and executive function. Executive abilities were most frequently impaired in the patient group (39 % of the patients. Even when controlling for differences in processing speed, patients showed more executive deficits than controls. CONCLUSIONS: Controlling for processing speed, patients still showed impaired executive function compared to healthy controls. Reduced executive function thus appears to be the core neurocognitive deficit in LLD. Executive function seems

  4. Plate tectonics in the late Paleozoic

    Institute of Scientific and Technical Information of China (English)

    Mathew Domeier; Trond H. Torsvik

    2014-01-01

    As the chronicle of plate motions through time, paleogeography is fundamental to our understanding of plate tectonics and its role in shaping the geology of the present-day. To properly appreciate the history of tectonicsdand its influence on the deep Earth and climatedit is imperative to seek an accurate and global model of paleogeography. However, owing to the incessant loss of oceanic lithosphere through subduction, the paleogeographic reconstruction of‘full-plates’ (including oceanic lithosphere) becomes increasingly challenging with age. Prior to 150 Ma w60% of the lithosphere is missing and re-constructions are developed without explicit regard for oceanic lithosphere or plate tectonic principles;in effect, reflecting the earlier mobilistic paradigm of continental drift. Although these ‘continental’ re-constructions have been immensely useful, the next-generation of mantle models requires global plate kinematic descriptions with full-plate reconstructions. Moreover, in disregarding (or only loosely applying) plate tectonic rules, continental reconstructions fail to take advantage of a wealth of additional information in the form of practical constraints. Following a series of new developments, both in geo-dynamic theory and analytical tools, it is now feasible to construct full-plate models that lend themselves to testing by the wider Earth-science community. Such a model is presented here for the late Paleozoic (410e250 Ma) together with a review of the underlying data. Although we expect this model to be particularly useful for numerical mantle modeling, we hope that it will also serve as a general framework for understanding late Paleozoic tectonics, one on which future improvements can be built and further tested.

  5. Teaching surgery in late Byzantine Alexandria.

    Science.gov (United States)

    Scarborough, John

    2010-01-01

    When one examines Alexandrian commentaries on works of Galen and Hippocrates, disclosed are essential guides to the Art of Medicine as practiced in the late fifth, sixth, and early seventh centuries. These are outlines and contents of a 'medical curriculum' in late Byzantine Alexandria, as well as Ravenna, and thanks to the patient and skilled labors of Dickson,' Duffy,2 Irmer, Palmieri, Pritchet, Westerink, and others, following and building on the pioneering studies of Bräutigam, Meyerhoff, and Temkin, medical historians can now peruse carefully edited Greek and Latin texts and generally reliable translations of some commentaries by Agnellus of Ravenna, John of Alexandria, Palladius, and Stephanus of Athens. Deeply experienced medical practitioners became teachers of would-be medical students in Alexandria and Ravenna. Alexandria had long functioned as a city reputed to be the home of medical instruction, and by ca. 550 or slightly later, teachers began to produce commentaries on the classic texts of Greek and Roman medicine, with Galen and Hippocrates as major authorities. Underpinning what the medical professors set down in their commentaries were extended lives spent in the actual practice of medicine, sometimes as military physicians (as may have been the case of Paul of Aegina in the early seventh century), sometimes as doctors who had gained lengthy experience in Alexandria itself, and sometimes as medical professionals who had emigrated to Egypt after successful careers in another part of the Greek-speaking eastern Roman Empire. Reflecting time as a medical student and later career in Constantinople, Aetius of Amida's Tetrabiblon foreshadows editorial mechanics and techniques of textual exegesis as they emerge more clearly with the medical commentators after 550. It may well be that Stephanus, 'the Philosopher and Physician', was originally from Athens, but whether he was or not, the attribution of an Athenian background suggests that non

  6. Gratkorn - A new late Middle Miocene vertebrate fauna from Styria (Late Sarmatian, Austria)

    Science.gov (United States)

    Gross, M.; Böhme, M.; Prieto, J.

    2009-04-01

    Integrated stratigraphic approaches provide precise correlations of global standard stages with regional Paratethys stages. Nevertheless, higher resolution stratigraphic matching of terrestrial deposits remains challenging due to the lack of a practical continental biostratigraphy. The mostly used tool for biostratigraphic correlation of non-marine deposits in the Old World is still the concept of Neogene Mammal-zones (MN-zones). However, at higher biostratigraphic resolution (imprints of gnawing structures. These taphonomic features point to a longer surface exposure before burial without considerable transportation. Trampling and the activity of scavengers (crunching, displacement of cadavers) are probable. Locally small- and medium-sized mammal remains (jaws and postcranial elements) of e.g., hamsters, flying squirrels, gymnures and shrews are concentrated, perhaps demonstrating feeding places of carnivores or more probably of birds of prey. Nonetheless, from geologic point of view, this paleosol represents an event horizon, which accumulated rapidly maybe within tens or hundreds of years. The vertebrate fauna comprises of scattered fishes (e.g. cyprinids, gobiids, ?channids), amphibians (e.g. salamandrids, ranids, discoglossids, bufonids, pelobatids,), reptiles (scincids, lacertids, gekkonids, anguids, varanids, colubrids, testudinids, emydids), birds (coliiformes), rodents and lagomorphs (cricetids, glirids, eomyids, sciurids, castorids), insectivores and chiropterans (erinaceids, soricids, talpids), and large mammals (suids, tragulids, moschids, cervids, ?palaeomerycids, equids, chalicotheriids, rhinos, proboscidians, carnivors). Litho- and biostratigraphy (terrestrial gastropods) as well as magnetostratigraphic data and the sequence stratigraphic and geodynamic frame indicate an age of 12-12.2 Ma (early Late Sarmatian s.str., chron 5An.1n) for the locality. Therefore, Gratkorn is one of richest and most complete fauna of the late Middle Miocene of Central

  7. Late Globalization and Evolution and Metamorphoses of Industries

    DEFF Research Database (Denmark)

    Boujarzadeh, Behnam; Turcan, Romeo V.; Dholakia, Nikhilesh

    2016-01-01

    In this paper we explore the effect of late globalization on evolution of industries. Specifically we investigate the impact of late globalization on the evolution and metamorphoses of Danish Textile and Fashion Industry (DTFI). Using historical data, we survey the development of DTFI between 194...... the effects of late globalization on DTFI’s size, mission, location, knowledge, growth and structure. With this paper we aim to generate fine-grained, substantive case details that would contribute towards the development of a theory (or theories) of late globalization....

  8. Comparative Earth history and Late Permian mass extinction

    Science.gov (United States)

    Knoll, A. H.; Bambach, R. K.; Canfield, D. E.; Grotzinger, J. P.

    1996-01-01

    The repeated association during the late Neoproterozoic Era of large carbon-isotopic excursions, continental glaciation, and stratigraphically anomalous carbonate precipitation provides a framework for interpreting the reprise of these conditions on the Late Permian Earth. A paleoceanographic model that was developed to explain these stratigraphically linked phenomena suggests that the overturn of anoxic deep oceans during the Late Permian introduced high concentrations of carbon dioxide into surficial environments. The predicted physiological and climatic consequences for marine and terrestrial organisms are in good accord with the observed timing and selectivity of Late Permian mass extinction.

  9. The fallacy of late-life divorce in Japan.

    Science.gov (United States)

    Kumagai, Fumie

    2006-01-01

    Late-life divorces in Japan, that is, divorces by couples with more than 20 years' duration of marriage at the time of divorce, have become increasingly conspicuous since in the mid-1990s. However, an increase in the number of late-life divorces is not the same as an increase in the divorce rate. That is, the conspicuous phenomenon of late-life divorces may not reflect the true nature of the institution of divorce. It may be a fallacy of late-life divorce in Japan today. This is the starting point of the present study. Five major findings have emerged. First, late-life divorces did increase dramatically over the recent past. Second, late-life divorces will continue to increase after 2007, when the new old-age pension division scheme for couples who pursue divorce will be in effect. Third, the increment in late-life divorce cases is due primarily to the baby-boomers born between 1947 and 1949 who are pursuing such late-life divorces. Fourth, as the duration of marriage increases, Japanese married couples are less inclined to pursue divorce. Fifth, the reasons for late-life divorces differ from those expressed for divorces in general. It is hoped that these findings will provide valuable insights for Japanese couples married for many years who may wish to reconsider and to reconstruct their marital relationship for the better.

  10. Late style as exile: De/colonising the life course.

    Science.gov (United States)

    Hartung, Heike

    2016-12-01

    In the collection of essays On Late Style, Edward Said reflects on the new idiom achieved by great artists in their work near the end of their lives as "late style." Drawing on Adorno's essay on Beethoven's late style, Said also focuses on the aesthetic aspects of lateness. Defining the late works of artists as "a form of exile," however, Said moves beyond Adorno's aesthetic conception of late style. Highlighting the artist's abandonment of communication with the established social order, who achieves a contradictory, alienated relationship with it instead, Said compares artistic lateness with the experience of the subject in exile. Drawing on the analogy provided by Said, this article argues that the relationship between "self" and "other" in the different theoretical contexts of Postcolonial Studies and Age Studies can be usefully combined in the composite concept of "late style as exile." In order to explore how the concept of lateness correlates with that of exile, this contribution turns to theoretical and autobiographical texts by Edward Said.

  11. Integrated Sr isotope variations and global environmental changes through the Late Permian to early Late Triassic

    Science.gov (United States)

    Song, Haijun; Wignall, Paul B.; Tong, Jinnan; Song, Huyue; Chen, Jing; Chu, Daoliang; Tian, Li; Luo, Mao; Zong, Keqing; Chen, Yanlong; Lai, Xulong; Zhang, Kexin; Wang, Hongmei

    2015-08-01

    New 87Sr/86Sr data based on 127 well-preserved and well-dated conodont samples from South China were measured using a new technique (LA-MC-ICPMS) based on single conodont albid crown analysis. These reveal a spectacular climb in seawater 87Sr/86Sr ratios during the Early Triassic that was the most rapid of the Phanerozoic. The rapid increase began in Bed 25 of the Meishan section (GSSP of the Permian-Triassic boundary, PTB), and coincided closely with the latest Permian extinction. Modeling results indicate that the accelerated rise of 87Sr/86Sr ratios can be ascribed to a rapid increase (>2.8×) of riverine flux of Sr caused by intensified weathering. This phenomenon could in turn be related to an intensification of warming-driven runoff and vegetation die-off. Continued rise of 87Sr/86Sr ratios in the Early Triassic indicates that continental weathering rates were enhanced >1.9 times compared to those of the Late Permian. Continental weathering rates began to decline in the middle-late Spathian, which may have played a role in the decrease of oceanic anoxia and recovery of marine benthos. The 87Sr/86Sr values decline gradually into the Middle Triassic to an equilibrium values around 1.2 times those of the Late Permian level, suggesting that vegetation coverage did not attain pre-extinction levels thereby allowing higher runoff.

  12. Never too late? An advantage on tests of auditory attention extends to late bilinguals.

    Directory of Open Access Journals (Sweden)

    Thomas Hieronymus Bak

    2014-05-01

    Full Text Available Recent studies, using predominantly visual tasks, indicate that early bilinguals outperform monolinguals on attention tests. It remains less clear whether such advantages extend to those bilinguals who have acquired their second language later in life.We examined this question in 38 monolingual and 60 bilingual university students. The bilingual group was further subdivided into early childhood, late childhood and early adulthood bilinguals. The assessment consisted of five subtests from the clinically validated Test of Everyday Attention (TEA. Overall, bilinguals outperformed monolinguals on auditory attention tests, but not on visual search tasks. The latter observation suggests that the differences between bilinguals and monolinguals are specific and not due to a generally higher cognitive performance in bilinguals.Within the bilingual group, early childhood bilinguals showed a larger advantage on attention switching, late childhood/early adulthood bilinguals on selective attention. We conclude that the bilingual advantage extends into the auditory domain and is not confined to childhood bilinguals, although its scope might be slightly different in early and late bilinguals.

  13. Surfactant therapy in late preterm infants

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    Murat Yurdakök

    2013-06-01

    Full Text Available Late preterm (LPT neonates are at a high risk for respiratory distress soon after birth due to respiratory distress syndrome (RDS, transient tachypnea of the newborn, persistent pulmonary hypertension, and pneumonia along with an increased need for surfactant replacement therapy, continuous positive airway pressure, and ventilator support when compared with the term neonates. In the past, studies on outcomes of infants with respiratory distress have primarily focused on extremely premature infants, leading to a gap in knowledge and understanding of the developmental biology and mechanism of pulmonary diseases in LPT neonates. Surfactant deficiency is the most frequent etiology of RDS in very preterm and moderately preterm infants, while cesarean section and lung infection play major roles in RDS development in LPT infants. The clinical presentation and the response to surfactant therapy in LPT infants may be different than that seen in very preterm infants. Incidence of pneumonia and occurrence of pneumothorax are significantly higher in LPT and term infants. High rates of pneumonia in these infants may result in direct injury to the type II alveolar cells of the lung with decreasing synthesis, release, and processing of surfactant. Increased permeability of the alveolar capillary membrane to both fluid and solutes is known to result in entry of plasma proteins into the alveolar hypophase, further inhibiting the surface properties of surfactant. However, the oxygenation index value do not change dramatically after ventilation or surfactant administration in LPT infants with RDS compared to very preterm infants. These finding may indicate a different pathogenesis of RDS in late preterm and term infants. In conclusion, surfactant therapy may be of significant benefit in LPT infants with serious respiratory failure secondary to a number of insults. However, optimal timing and dose of administration are not so clear in this group. Additional

  14. Floral responses to the Late Paleozoic deglaciation

    Science.gov (United States)

    Looy, C. V.; DiMichele, W. A.

    2011-12-01

    The current human-induced thawing of ice house Earth prompts the careful examination of similar earlier events and their biotic consequences. The most recent full transition from a cool earth to a warm world took place in the Early to Middle Permian. Against a background of global warming, plant communities were affected globally resulting in migrations, extinctions and changed evolutionary patterns as a response to the environmental changes. The collapse of the southern hemisphere ice-sheets resulted in significant changes, not just at higher latitudes, but also in the tropics where the rainfall regime changed from seasonally dry to seasonally wet. In the Early Permian tropics - in areas where net sedimentation facilitates fossilization, to be more specific - vegetation rich in walchian conifers began to replace the spore plants and seed ferns that previously dominated the Late Pennsylvanian wetlands. The replacing drier floras probably lived in the basinal lowlands as well, but episodically at the drier times of climate cycles. New finds within the tropics of latest Early to Middle Permian-age, in particular from north-central Texas, indicate the existence of floras which were adapted to even more extended periods of drought. These were populated by the more derived voltzian conifers and other seed plants, such as cycads. Surprisingly, the clades in these floras were until recently only known from the tens-of-millions-of-years younger Late Permian and Early Mesozoic, where they were the dominant forms. These occurrences demonstrate that even more derived groups were already in existence and well differentiated by the Early Permian, outside the window of preservation. This pattern of change in conifers and their communities from north-central Texas is unique in that it represents the best documented record in the Phanerozoic of terrestrial ecosystem response to a change from a global cool-mode to warm-mode Earth. Conifers serve as "marker plants" for the

  15. The late Precambrian greening of the Earth.

    Science.gov (United States)

    Knauth, L Paul; Kennedy, Martin J

    2009-08-01

    Many aspects of the carbon cycle can be assessed from temporal changes in the (13)C/(12)C ratio of oceanic bicarbonate. (13)C/(12)C can temporarily rise when large amounts of (13)C-depleted photosynthetic organic matter are buried at enhanced rates, and can decrease if phytomass is rapidly oxidized or if low (13)C is rapidly released from methane clathrates. Assuming that variations of the marine (13)C/(12)C ratio are directly recorded in carbonate rocks, thousands of carbon isotope analyses of late Precambrian examples have been published to correlate these otherwise undatable strata and to document perturbations to the carbon cycle just before the great expansion of metazoan life. Low (13)C/(12)C in some Neoproterozoic carbonates is considered evidence of carbon cycle perturbations unique to the Precambrian. These include complete oxidation of all organic matter in the ocean and complete productivity collapse such that low-(13)C/(12)C hydrothermal CO(2) becomes the main input of carbon. Here we compile all published oxygen and carbon isotope data for Neoproterozoic marine carbonates, and consider them in terms of processes known to alter the isotopic composition during transformation of the initial precipitate into limestone/dolostone. We show that the combined oxygen and carbon isotope systematics are identical to those of well-understood Phanerozoic examples that lithified in coastal pore fluids, receiving a large groundwater influx of photosynthetic carbon from terrestrial phytomass. Rather than being perturbations to the carbon cycle, widely reported decreases in (13)C/(12)C in Neoproterozoic carbonates are more easily interpreted in the same way as is done for Phanerozoic examples. This influx of terrestrial carbon is not apparent in carbonates older than approximately 850 Myr, so we infer an explosion of photosynthesizing communities on late Precambrian land surfaces. As a result, biotically enhanced weathering generated carbon-bearing soils on a large

  16. Trade and Transport in Late Roman Syria

    Science.gov (United States)

    Fletcher, Christopher

    Despite the relative notoriety and miraculous level of preservation of the Dead Cities of Syria, fundamental questions of economic and subsistence viability remain unanswered. In the 1950s Georges Tchalenko theorized that these sites relied on intensive olive monoculture to mass export olive oil to urban centers. Later excavations discovered widespread cultivation of grains, fruit, and beans which directly contradicted Tchalenko's assertion of sole reliance on oleoculture. However, innumerable olive presses in and around the Dead Cities still speak to a strong tradition of olive production. This thesis tests the logistical viability of olive oil transportation from the Dead Cities to the distant urban centers of Antioch and Apamea. Utilization of Raster GIS and remote sensing data allows for the reconstruction of the physical and social landscapes of Late Roman Syria. Least Cost Analysis techniques produce a quantitative and testable model with which to simulate and evaluate the viability of long distance olive oil trade. This model not only provides a clearer understanding of the nature of long distance trade relationships in Syria, but also provides a model for investigating ancient economic systems elsewhere in the world. Furthermore, this project allows for the generation of new information regarding sites that are currently inaccessible to researchers.

  17. Late neuropsychologic status after childhood head trauma.

    Science.gov (United States)

    Costeff, H; Abraham, E; Brenner, T; Horowitz, I; Apter, N; Sadan, N; Najenson, T

    1988-01-01

    A neurologic and neuropsychologic test battery was administered to a sample of 35 children drawn from all those in a defined geographic area who had been hospitalized for head trauma before age 7 during the years 1970-1976. Examination was performed 3 1/2 to 10 years after injury, at age 6-15. Twelve subjects had been diagnosed at the time of injury as suffering moderate insult and had been referred to the metropolitan neurosurgical center, while twenty-three with only mild injury had been retained for observation in a local pediatric ward. The twelve with more severe insult were significantly inferior to the other subjects on the Block Design and Coding subtests of the revised Wechsler Intelligence Scale for Children. The Koppitz score of the Bender Test, the WISC-R scatter, the Benton Visual Retention Test, the GATB Motor Speed Test and the Bourdon-Wiersma Vigilance Test showed less diagnostic power and failed to distinguish between the group with more severe injury and that with less. A detailed and carefully scored neurologic examination also failed to distinguish between the two groups. The findings suggest that relatively common traumatic injury may be associated with detectable late cognitive deficit, and that some WISC-R subtests may be among the best measures for detecting such deficit.

  18. Post-Traumatic Late Onset Cerebral Ischemia

    Directory of Open Access Journals (Sweden)

    Gencer Genc

    2014-03-01

    Full Text Available Artery-to-artery emboli or occlusion of craniocervical arteries mostly due to dissection are the most common causes of ischemia after trauma. A 29 year-old male had been admitted to another hospital with loss of consciousness lasting for about 45 minutes after a hard parachute landing without head trauma three days ago. As his neurological examination and brain CT were normal, he had been discharged after 24 hours of observation. Two days after his discharge, he was admitted to our department with epileptic seizure. His neurological examination revealed left hemianopia. After observing occipital subacute ischemia at right side in brain magnetic resonance imaging (MRI, we performed cerebral angiography and no dissection was observed. Excluding the rheumatologic, cardiologic and vascular events, our final diagnosis was late onset cerebral ischemia. Anti-edema and antiepileptic treatment was initiated. He was discharged with left hemianopia and mild cognitive deficit. We suggest that it will be wise to hospitalize patients for at least 72 hours who has a history of unconsciousness following trauma.

  19. Queer theory, late capitalism, and internalized homophobia.

    Science.gov (United States)

    Kirsch, Max

    2006-01-01

    The emergence of queer theory represents a transformation in the approach to lesbian, gay, bisexual and transgendered peoples. It has claimed new ground for treating sexuality and gender as worthy subjects in their own rights, rather than offshoots of gay and lesbian studies or of general cultural theory. The author contends, however, that it is doubtful that this approach can lead to social change. Queer theory has dismissed the usefulness of the disciplines that were the foundation of the social movements that initiated gay and lesbian studies, such as political economy, and in doing so, it has surreptitiously mirrored the social relations of reproduction that constitute late capitalism. This mirroring has had unseen consequences for the individual in society, and with queer theory's insistence on the relativity of experience and the dismissal of identity, has set the stage for a benign reinforcement of internalized homophobia. The author argues that this approach can be mediated by recognizing that identity is fluid, and that by focusing on identifying with social movements rather than centering analyses on the problems associated with identifying as a particular category of status and being, we can refocus our energies on the building and maintenance of mutual support and collective recognition that can lead to resolving the stagnation now dominating attempts to develop coalitions around issues that matter.

  20. Late stage infection in sleeping sickness.

    Directory of Open Access Journals (Sweden)

    Hartwig Wolburg

    Full Text Available At the turn of the 19(th century, trypanosomes were identified as the causative agent of sleeping sickness and their presence within the cerebrospinal fluid of late stage sleeping sickness patients was described. However, no definitive proof of how the parasites reach the brain has been presented so far. Analyzing electron micrographs prepared from rodent brains more than 20 days after infection, we present here conclusive evidence that the parasites first enter the brain via the choroid plexus from where they penetrate the epithelial cell layer to reach the ventricular system. Adversely, no trypanosomes were observed within the parenchyma outside blood vessels. We also show that brain infection depends on the formation of long slender trypanosomes and that the cerebrospinal fluid as well as the stroma of the choroid plexus is a hostile environment for the survival of trypanosomes, which enter the pial space including the Virchow-Robin space via the subarachnoid space to escape degradation. Our data suggest that trypanosomes do not intend to colonize the brain but reside near or within the glia limitans, from where they can re-populate blood vessels and disrupt the sleep wake cycles.

  1. History of Late-Notice HIEs

    Science.gov (United States)

    Frakes, P.

    2016-01-01

    Question was raised: are we seeing more late-notice events in recent months? Two definitions oflate-notice used to compare data: Event has at least one data point between TCA-4 days and TCA-2 days where the Pcwas below 1E-7, OR there were no data points in that timeframe. Event has at least one data point between TCA-2days and TCA where the Pc was at least 1E-4Event has at least one data point between TCA-4 days and TCA-2 dayswhere the Pc was below 1E-5, OR there were no data points in that timeframe. Event has at least one data pointbetween TCA-2 days and TCA where the Pc was at least 1E-4. The case studies that were examined all fall within criteriafor both definitions Terra vs 38192; TCA 24 JUN 2015Aura vs 89477; TCA 29 AUG 2015Terra vs 37131; TCA 19 DEC2015GPM vs 28685; TCA 5 SEP 2015.

  2. Was there a late Archean biospheric explosion?

    Science.gov (United States)

    Lindsay, John F

    2008-08-01

    There is a growing body of evidence which suggests that the evolution of the planet drives the evolution of the biosphere. There have been 2 significant stages in Earth history when atmospheric oxygen levels rose rapidly, and both appear to be associated with supercontinent cycles. The earlier biospheric event, which extends across the Archean-Proterozoic boundary (ca. 3.0-2.2 Ga), has received little attention and is the focus of this study. Recent work on the Pilbara Craton of Western Australia has shown that concretion formed by microbial activity during the diagenesis of these sediments are absent from early Archean sediments but abundant in late Archean and early Paleoproterozoic successions of the Hamersley Basin, appearing abruptly in sedimentary rocks younger than 2.7 Ga. This study suggests that their internal architecture may have been defined by the diffusion of humic acids and the formation of polymer gels during diagenesis. The data imply that the biosphere expanded suddenly shortly after 3.0 Ga and may have begun to raise the oxygen levels of the oceanic water column earlier than thought-possibly as much as 300 my earlier.

  3. Musical Training and Late-Life Cognition.

    Science.gov (United States)

    Gooding, Lori F; Abner, Erin L; Jicha, Gregory A; Kryscio, Richard J; Schmitt, Fredrick A

    2014-06-01

    This study investigated the effects of early- to midlife musical training on cognition in older adults. A musical training survey examined self-reported musical experience and objective knowledge in 237 cognitively intact participants. Responses were classified into low-, medium-, and high-knowledge groups. Linear mixed models compared the groups' longitudinal performance on the Animal Naming Test (ANT; semantic verbal fluency) and Logical Memory Story A Immediate Recall (LMI; episodic memory) controlling for baseline age, time since baseline, education, sex, and full-scale IQ. Results indicate that high-knowledge participants had significantly higher LMI scores at baseline and over time compared to low-knowledge participants. The ANT scores did not differ among the groups. Ability to read music was associated with higher mean scores for both ANT and LMI over time. Early- to midlife musical training may be associated with improved late-life episodic and semantic memory as well as a useful marker of cognitive reserve. © The Author(s) 2013.

  4. Compton Composites Late in the Early Universe

    Directory of Open Access Journals (Sweden)

    Frederick Mayer

    2014-07-01

    Full Text Available Beginning roughly two hundred years after the big-bang, a tresino phase transition generated Compton-scale composite particles and converted most of the ordinary plasma baryons into new forms of dark matter. Our model consists of ordinary electrons and protons that have been bound into mostly undetectable forms. This picture provides an explanation of the composition and history of ordinary to dark matter conversion starting with, and maintaining, a critical density Universe. The tresino phase transition started the conversion of ordinary matter plasma into tresino-proton pairs prior to the the recombination era. We derive the appropriate Saha–Boltzmann equilibrium to determine the plasma composition throughout the phase transition and later. The baryon population is shown to be quickly modified from ordinary matter plasma prior to the transition to a small amount of ordinary matter and a much larger amount of dark matter after the transition. We describe the tresino phase transition and the origin, quantity and evolution of the dark matter as it takes place from late in the early Universe until the present.

  5. Late Embryogenesis Abundant (LEA proteins in legumes

    Directory of Open Access Journals (Sweden)

    Marina eBattaglia

    2013-06-01

    Full Text Available Plants are exposed to different external conditions that affect growth, development, and productivity. Water deficit is one of these adverse conditions caused by drought, salinity, and extreme temperatures. Plants have developed different responses to prevent, ameliorate or repair the damage inflicted by these stressful environments. One of these responses is the activation of a set of genes encoding a group of hydrophilic proteins that typically accumulate to high levels during seed dehydration, at the last stage of embryogenesis, hence named Late Embryogenesis Abundant (LEA proteins. LEA proteins also accumulate in response to water limitation in vegetative tissues, and have been classified in seven groups based on their amino acid sequence similarity and on the presence of distinctive conserved motifs. These proteins are widely distributed in the plant kingdom, from ferns to angiosperms, suggesting a relevant role in the plant response to this unfavorable environmental condition. In this review, we analyzed the LEA proteins from those legumes whose complete genomes have been sequenced such as Phaseolus vulgaris, Glycine max, Medicago truncatula, Lotus japonicus, Cajanus cajan and Cicer arietinum. Considering their distinctive motifs, LEA proteins from the different groups were identified, and their sequence analysis allowed the recognition of novel legume specific motifs. Moreover, we compile their transcript accumulation patterns based on publicly available data. In spite of the limited information on these proteins in legumes, the analysis and data compiled here confirms the high correlation between their accumulation and water deficit, reinforcing their functional relevance under this detrimental conditions.

  6. Review Essay: Governmentality in Late Colonial Korea?

    Directory of Open Access Journals (Sweden)

    Henry Em

    2012-12-01

    Full Text Available Takashi Fujitani, Race for Empire: Koreans as Japanese and Japanese as Americans during World War II. Berkeley: University of California Press, 2011. 520 pp. $65 (cloth.Jun Uchida, Brokers of Empire: Japanese Settler Colonialism in Korea, 1876-1945. Cambridge, MA: Harvard University Press, 2011. 500 pp. $50 (cloth.In South Korea, more so than in most other postcolonial countries, the issue of sovereignty and the colonial past remains a central feature of politics. Most recently, during a televised presidential debate on December 4, 2012, Lee Jung-hee of the Unified Progressive Party said something that likely had never been said on South Korean television: “Takaki Masao signed an oath of loyalty [to the Emperor of Japan], in his own blood, to become an officer in the Japanese [Imperial] Army. You know who he is. His Korean name is Park Chung Hee.” Lee Jung-hee then made the connection between that colonial past and the willingness to sell out the nation’s sovereignty in the present. The conservative candidate Park Geun-hye, the daughter of the late President Park Chung Hee who ruled South Korea from 1961 through 1979, and members of Park’s Saenuri Party, remain true to their “roots”: these “descendants of pro-Japanese collaborators and dictators” (again sold out South Korea’s sovereignty (on November 22, 2011 when they rammed the US-ROK Free Trade Agreement through the National Assembly.

  7. On the Late Invention of the Gyroscope

    Science.gov (United States)

    Brecher, Kenneth

    2012-03-01

    The invention of the gyroscope is usually attributed to the French physicist Jean-Bernard-Leon Foucault in 1852. He certainly invented the word and also used his gyroscope to demonstrate the rotation of the Earth. However, the gyroscope was actually invented around 1812 by German physicist Johann Bohnenberger who called his device simply the ``machine''. Several others, including American physicist Walter R. Johnson (who called his apparatus the ``rotascope''), independently invented the gyroscope in the 1830's. Each of these devices employed a central object (sphere or disc) that could spin freely on a shaft. This was placed between three independent gimbals, which could also move freely. Bohnenberger's ``machine'' has much the same appearance as an armillary sphere. Such devices had been produced for at least the preceding three centuries. They were used to display the movements of various celestial bodies. However, armillary spheres are only simulations of celestial appearances, not actual demonstrations of physical phenomena. Gimbal systems similar to those found in gyroscopes were used on ships to level oil lamps from at least the sixteenth century and the ideas behind armillary spheres date back at least a millennium before that. So why was the gyroscope invented so late? Some possible reasons will be presented for the long delay between the development of the individual underlying components and the eventual appearance of the gyroscope in its modern form.

  8. Late Holocene rainforest disturbance in French Guiana.

    Science.gov (United States)

    Ledru, M -P.

    2001-06-01

    Palm swamp forest sediments collected in French Guiana provide new data about late Holocene rainforest. Two cores were collected in 'Les Nouragues' ecological station (4 degrees 05'N, 52 degrees 40'W). The lithology shows two different types of sediment, organic peat in the upper part and oxidized clay with low organic content and lacking pollen in the lower part, both separated by a gravel horizon. Radiocarbon dates show that this gravel horizon could have been deposited between 4500 and 3000yrBP. Pollen analysis carried out on the organic sediments record rainforest disturbances between ca 1520-1380 and 1060-860cal yrBP suggested by the presence of the pioneer tree species Cecropia together with other shade intolerant genera. Cecropia is recorded for a period that lasts between 660 and 320 years. This abnormal duration for presence of a pioneer species in rainforest is explained by brief and repeated changes in the composition of the canopy asssociated to perturbations of the palm swamp.

  9. Research and clinical aspects of the late effects of poliomyelitis

    Energy Technology Data Exchange (ETDEWEB)

    Halstead, L.S.; Wiechers, D.O.

    1986-01-01

    This book contains 32 selections. Some of the titles are: Late effects of Polio: Historical Perspectives; Sleep-Disordered Breathing as a Late Effect of Poliomyelitis; Clinical Subtypes, DNA Repair Efficiency, and Therapeutic Trials in the Post-Polio Syndromes; and Post-Polio Muscle Function.

  10. Pragmatic Functions of Toddlers Who Are Late Talkers

    Science.gov (United States)

    MacRoy-Higgins, Michelle; Kaufman, Ilana

    2012-01-01

    Toddlers who are "late talkers" demonstrate reduced expressive vocabulary in the absence of physical, social, cognitive, or sensory impairment; they are usually identified at age 2, when they produce fewer than 50 words and do not combine words (Rescorla, 1989). This study analyzed spontaneous language samples of 10 late talking toddlers and 11…

  11. SPECT and PET in Late-Life Depression

    NARCIS (Netherlands)

    Vieira, Tiago S; Oude Voshaar, Richard; De Deyn, Peter; Dierckx, Rudi; van Waarde, Aren; Dierckx, Rudi AJO; Otte, Andreas; de Vries, Erik FJ; van Waarde, Aren; den Boer, Johan A

    2014-01-01

    Late-life late onset depression (i.e., depression with an age of onset above 60 yrs) appears to differ from depression with early onset in its association with cerebral small vessel disease, beta-amyloid and tau deposition, and neurodegenerative processes. Multimodality imaging (SPECT, PET, MRI) sup

  12. Potato late blight epidemics and population structure of Phytophthora infestans.

    NARCIS (Netherlands)

    Zwankhuizen, M.J.

    1998-01-01

    Potato late blight is caused by the fungus Phytophthora infestans . To study the relative importance of oospores in the epidemiology, and to estimate the relative impact of various infection sources, late blight epidemics in Southern Flevoland (The Netherlands) were studied using epidemiological and

  13. Attention and Word Learning in Toddlers Who Are Late Talkers

    Science.gov (United States)

    MacRoy-Higgins, Michelle; Montemarano, Elizabeth A.

    2016-01-01

    The purpose of this study was to examine attention allocation in toddlers who were late talkers and toddlers with typical language development while they were engaged in a word-learning task in order to determine if differences exist. Two-year-olds who were late talkers (11) and typically developing toddlers (11) were taught twelve novel…

  14. Prevalence and factors associated with late HIV diagnosis.

    Science.gov (United States)

    Dai, Se-Ying; Liu, Jin-Ji; Fan, Yin-Guang; Shan, Gui-Su; Zhang, Hong-Bo; Li, Ming-Qiang; Ye, Dong-Qing

    2015-06-01

    While highly active antiretroviral therapy has been successful in delaying progression into AIDS, late HIV diagnosis remains a major contributor to the mortality and morbidity of AIDS. An epidemiological study was conducted to evaluate the prevalence and factors of late diagnosis and the characteristics of those individuals with late diagnosis in Liuzhou city. Patients with late diagnosis were defined as either those who were diagnosed with AIDS at the time of HIV diagnosis or as those who developed AIDS no more than 1 year after HIV diagnosis. Of 899 participants, 72.6% had a late diagnosis. Common characteristics of those who experienced late diagnosis included older participants, those who were unexpectedly diagnosed while seeking other medical attention, participants who believed they could not acquire HIV from their regular heterosexual partners, those who never considered getting tested for HIV, and patients with unexplained weight loss, angular cheilitis, or prolonged fever prior to HIV diagnosis. On the other hand, those participants who were diagnosed via testing at compulsory rehabilitation centers and those whose annual household income was greater than 30,000 Yuan were less likely to be diagnosed late. These results suggested that late HIV diagnosis is common in Liuzhou city, and it is essential to promote appropriate strategies to detect HIV infections earlier. Strategies that require HIV/AIDS patients to notify their spouse/sexual-partners about their HIV-positive results within one month and start provider-initiated HIV testing and counseling in medical facilities are beneficial to earlier HIV diagnosis.

  15. Proportion and Factors Associated with late Antenatal Care Booking ...

    African Journals Online (AJOL)

    AJRH Managing Editor

    ... of pregnancy. Multiple logistic regression analysis showed that respondents who didn't get information on correct ... and recognized their pregnancy by missing periods were more likely to book late. Late booking ... global maternal deaths, the majority of which were ... 20112, only around one tenth of pregnant mothers.

  16. Center Variation in the Delivery of Indicated Late Preterm Births.

    Science.gov (United States)

    Aliaga, Sofia; Zhang, Jun; Long, D Leann; Herring, Amy H; Laughon, Matthew; Boggess, Kim; Reddy, Uma M; Grantz, Katherine Laughon

    2016-08-01

    Objective Evidence for optimal timing of delivery for some pregnancy complications at late preterm gestation is limited. The purpose of this study was to identify center variation of indicated late preterm births. Study design We performed an analysis of singleton late preterm and term births from a large U.S. retrospective obstetrical cohort. Births associated with spontaneous preterm labor, major congenital anomalies, chorioamnionitis, and emergency cesarean were excluded. We used modified Poisson fixed effects logistic regression with interaction terms to assess center variation of indicated late preterm births associated with four medical/obstetric comorbidities after adjusting for socio-demographics, comorbidities, and hospital/provider characteristics. Results We identified 150,055 births from 16 hospitals; 9,218 were indicated late preterm births. We found wide variation of indicated late preterm births across hospitals. The extent of center variation was greater for births associated with preterm premature rupture of membranes (risk ratio [RR] across sites: 0.45-3.05), hypertensive disorders of pregnancy (RR across sites: 0.36-1.27), and placenta previa/abruption (RR across sites: 0.48-1.82). We found less center variation for births associated with diabetes (RR across sites: 0.65-1.39). Conclusion Practice variation in the management of indicated late preterm deliveries might be a source of preventable late preterm birth.

  17. Coping and Late-Deafness: An Examination of Two Measures

    Science.gov (United States)

    Meyer, Jill M.; Kashubeck-West, Susan

    2015-01-01

    Purpose: To examine the psychometric properties of two measures of coping in a sample of individuals with acquired hearing loss, specifically late-deafness. Methods: Using a quantitative descriptive design, coping of participants (N = 277) with late-deafness was measured to examine the reliability and validity of the Ways of Coping Questionnaire…

  18. Late Career Decision-Making: A Qualitative Panel Study

    NARCIS (Netherlands)

    Furunes, Trude; Mykletun, Reidar; Solem, Per Erik; Lange, Annet de; Syse, Astri; Schaufeli, Wilmar; Ilmarinen, Juhani

    2015-01-01

    The aim of this longitudinal qualitative interview study (3 waves of interviews) was to examine the nature of older workers’ late career decision-making processes, including the main drivers and obstacles for prolonging working life or retiring. Late career decision-making is regarded as a process o

  19. Late time tail of wave propagation on curved spacetime

    CERN Document Server

    Ching, E S C; Suen, W M; Young, K; Ching, E S C; Leung, P T; Suen, W M; Young, K

    1994-01-01

    The late time behavior of waves propagating on a general curved spacetime is studied. The late time tail is not necessarily an inverse power of time. Our work extends, places in context, and provides understanding for the known results for the Schwarzschild spacetime. Analytic and numerical results are in excellent agreement.

  20. Late Entrants Leave School Earlier: Evidence from Mozambique

    Science.gov (United States)

    Wils, Annababette

    2004-01-01

    Late school entry prevails in many developing countries, and a brief international comparison suggests it has a general negative impact on school retention rates. Yet this widespread phenomenon has received little attention. This essay investigates late school entry in one of the larger countries in sub-Saharan Africa, Mozambique, for which data…

  1. Differential Parenting between Mothers and Fathers: Implications for Late Adolescents

    Science.gov (United States)

    McKinney, Cliff; Renk, Kimberly

    2008-01-01

    Although the relationship between parenting and outcomes for children and adolescents has been examined, differences between maternal and paternal parenting styles have received less attention, particularly in the case of late adolescents. As a result, this article examines the relationship between late adolescents' perceptions of their mothers'…

  2. Development of late blight resistant potatoes by cisgenic stacking

    NARCIS (Netherlands)

    Jo, K.R.; Kim, C.J.; Kim, S.J.; Kim, T.J.; Bergervoet-van Deelen, J.E.M.; Jongsma, M.A.; Visser, R.G.F.; Jacobsen, E.; Vossen, J.H.

    2014-01-01

    Background Phytophthora infestans, causing late blight in potato, remains one of the most devastating pathogens in potato production and late blight resistance is a top priority in potato breeding. The introduction of multiple resistance (R) genes with different spectra from crossable species into

  3. 7 CFR 927.123 - Interest and late payment charges.

    Science.gov (United States)

    2010-01-01

    ... applied to the total unpaid balance, including the late payment charge and any accumulated interest. Any... 7 Agriculture 8 2010-01-01 2010-01-01 false Interest and late payment charges. 927.123 Section 927... payment charges. Payments received more than 45 days after the date on which they are due shall...

  4. Role of Solanum dulcamara L. in Potato Late Blight Epidemiology

    NARCIS (Netherlands)

    Golas, T.M.; Weerden, van der G.M.; Berg, van den R.G.; Mariani, C.; Allefs, J.J.H.M.

    2010-01-01

    Four sites with naturally growing Solanum dulcamara were surveyed during 2006 and 2007 for the presence of late blight. Despite 2 years of observations, no late blight was detected among natural populations of bittersweet. Nevertheless, repeated infections occurred on few S. dulcamara plants from a

  5. Differential Parenting between Mothers and Fathers: Implications for Late Adolescents

    Science.gov (United States)

    McKinney, Cliff; Renk, Kimberly

    2008-01-01

    Although the relationship between parenting and outcomes for children and adolescents has been examined, differences between maternal and paternal parenting styles have received less attention, particularly in the case of late adolescents. As a result, this article examines the relationship between late adolescents' perceptions of their mothers'…

  6. 7 CFR 947.141 - Late payment and interest charges.

    Science.gov (United States)

    2010-01-01

    ... payment charge shall, after 30 days, be five percent of the unpaid assessment balance. In the event the... 7 Agriculture 8 2010-01-01 2010-01-01 false Late payment and interest charges. 947.141 Section 947... Rules and Regulations Safeguards § 947.141 Late payment and interest charges. The committee shall impose...

  7. Morphology and Syntax in Late Talkers at Age 5

    Science.gov (United States)

    Rescorla, Leslie; Turner, Hannah L.

    2015-01-01

    Purpose: This study reports age 5 morphology and syntax skills in late talkers identified at age 2 (n = 34) and typically developing comparison children (n = 20). Results: The late talkers manifested significant morphological delays at ages 3 and 4 relative to comparison peers. Based on the 14 morphemes analyzed at age 5, the only significant…

  8. 38 CFR 21.9740 - False, late, or missing reports.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false False, late, or missing..., late, or missing reports. (a) Eligible individual. Payments may not be based on false or misleading....S.C. chapter 33 in the same manner as they are applied to people who make similar false...

  9. 38 CFR 21.7158 - False, late, or missing reports.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false False, late, or missing... (Montgomery GI Bill-Active Duty) Pursuit of Courses § 21.7158 False, late, or missing reports. (a) Veteran....C. chapter 30 in the same manner as they are applied to people who make similar false or...

  10. 38 CFR 21.7658 - False, late, or missing reports.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false False, late, or missing... Reserve Pursuit of Course and Required Reports § 21.7658 False, late, or missing reports. (a) Reservist... the same manner as they are applied to people who make similar false or misleading claims for...

  11. Late post-operative hypoxaemia and organ dysfunction

    DEFF Research Database (Denmark)

    Kehlet, H; Rosenberg, J

    1995-01-01

    an adverse effect of tissue hypoxia on wound healing and on resistance to bacterial wound infections. Finally, mental confusion and surgical delirium may be related to inadequate arterial oxygenation during the late post-operative period. Late post-operative constant and episodic hypoxaemia may therefore...

  12. Late presentation of HIV infection: a consensus definition

    DEFF Research Database (Denmark)

    Antinori, A; Coenen, T; Costagiola, D

    2010-01-01

    clinical definition of late presentation. The objective of this article is to present a consensus definition of late presentation of HIV infection. Methods Over the past year, two initiatives have moved towards a harmonized definition. In spring 2009, they joined efforts to identify a common definition...... of what is meant by a 'late-presenting' patient. Results Two definitions were agreed upon, as follows. Late presentation: persons presenting for care with a CD4 count below 350 cells/muL or presenting with an AIDS-defining event, regardless of the CD4 cell count. Presentation with advanced HIV disease...... able to implement this definition (either on its own or alongside their own preferred definition) when reporting surveillance or research data relating to late presentation of HIV infection....

  13. Interpersonal influences on late adolescent girls' and boys' disordered eating.

    Science.gov (United States)

    Shomaker, Lauren B; Furman, Wyndol

    2009-04-01

    Perceived socio-cultural pressure to be thin has an important impact on disordered eating during early and middle adolescence, but less is known about late adolescence. Most prospective studies included only girls, and less is known about the influence on boys. This study investigated interpersonal influences on changes in late adolescent boys' and girls' symptoms of disordered eating over one year. Participants were a community sample of late adolescents 16-19 years of age (N=199; 49.75% girls), their mothers, and friends. Structural equation modeling revealed that interpersonal pressure to be thin and criticism about appearance predicted increases in disordered eating over time. Late adolescents', mothers' and friends' reports of pressure were associated with disordered eating at Time 1 and Time 2. Further, adolescents' perceptions and friends' reports of pressure to be thin predicted changes in disordered eating over time. Findings underscore the significance of interpersonal relationships for disordered eating during late adolescence in both girls and boys.

  14. Three comments on late antiquity history

    Directory of Open Access Journals (Sweden)

    Milin Milena L.

    2003-01-01

    Full Text Available The author suggests corrections in reading the inscription CIL III 4002 lines 3-7 (see pp. 1-2. The formula q(ui vixit ann(os, lines 3-4, was common in Late Antiquity, unlike the previous reading...ann(orum, which was typical for the Early Empire. L.5 memoria frequently appeared in funerary monuments in Late Antiquity. L. 6 Instead of unlikely collegae, the complement colloc(avit or –erunt has been suggested, according to analogies sedem conlocasse (Siscia, CIL 3996 sepulcrum (! collocavit, with the Christogram ( Siscia,CIL 3996a. The inscription can be more precisely dated with regard to the Christogram. In nearby Sirmium, this symbol repeatedly appears in epitaphs, whether unaccompanied, or between the letters a and w. According to a dated inscription with a Christogram from Constantius times the entire group of inscriptions bearing this symbol may be supposed to have originated from mid-, or, at the latest, second half of 4th century (notes 2-4. Durostoranus (Amm. Marc. XXXI 15, 6 In the paragraph referred to above: Verum introire non ausus, qui missus est, per Christianum quendam portatis scriptis et recitatis, utque decebat, contemptatis parandis operibus dies et nox omnis absumpta (ed. W.Seyfarth, Leipzig 1978, the author instead of the reading to date, christianum, suggests the restitution of the Codex lection Vat. lat. 1873 diristanum, which would be the adjective derived from the toponym D(iristra, a variant of Durostorus, cf. Zonara (XVI 12 e/n Dorosto$lw...toy#to d h% Dri$stra e/sti. Further on, (...scriptis et recitatis, utque dicebat, contemptatis, parandis operibus dies et nox omnis absumpta, two differently noted or emendated points are present. The one is ut dicebat, in a later manuscript, and in Seyfarth's critical edition changed into ut decebat. This emendation is not necessary: the emissary said that he had taken the letter and given the message that was ignored by the inhabitants, and not "given the message as was

  15. Eszopiclone for late-life insomnia

    Directory of Open Access Journals (Sweden)

    Christina S McCrae

    2007-10-01

    Full Text Available Christina S McCrae1, Amanda Ross1, Ashley Stripling2, Natalie D Dautovich21Department of Clinical and Health Psychology, 2Department of Psychology, University of Florida, Gainesville, Florida, USAAbstract: Insomnia, the most common sleep disturbance in later life, affects 20%–50% of older adults. Eszopiclone, a short-acting nonbenzodiazepine hypnotic agent developed for the treatment of insomnia, has been available in Europe since 1992 and in the US since 2005. Although not yet evaluated for transient insomnia in older adults, eszopiclone has been shown to be safe and efficacious for short-term treatment (2 weeks of chronic, primary insomnia in older adults (64–91 years. Clinical studies in younger adults (mean = 44 years have shown eszopiclone can be used for 6–12 months without evidence of problems. Because the oldest participant in these longer-term trials was 69, it not known whether eszopiclone is effective for older adults [particularly the old old (75–84 years and oldest old (85+] when used over longer periods. This is unfortunate, because older individuals frequently suffer from chronic insomnia. Cognitive-behavioral therapy for insomnia, which effectively targets the behavioral factors that maintain chronic insomnia, represents an attractive treatment alternative or adjuvant to eszopiclone for older adults. To date, no studies have compared eszopiclone to other hypnotic medications or to nonpharmacological interventions, such as cognitive-behavioral therapy for insomnia, in older adults. All of the clinical trials reported herein were funded by Sepracor. This paper provides an overview of the literature on eszopiclone with special emphasis on its use for the treatment of late-life insomnia. Specific topics covered include pharmacology, pharmacodynamics, pharmacokinetics, clinical trial data, adverse events, drug interactions, tolerance/dependence, and economics/cost considerations for older adults. Keywords: aging, eszopiclone

  16. Late-onset hypogonadism: beyond testosterone

    Directory of Open Access Journals (Sweden)

    Carlo Foresta

    2015-04-01

    Full Text Available Late-onset hypogonadism is defined as a combination of low testosterone (T levels and typical symptoms and signs. A major area of uncertainty is whether T concentrations are always really sufficient to fully reflect Leydig cell (dysfunction. Mild testicular alteration could be diagnosed only by additional biochemical markers, such as luteinizing hormone (LH and 25-hydroxyvitamin D levels. These markers help in identifying the so-called "subclinical" hypogonadism (normal T, high LH levels. Patients with hypogonadism have frequently low levels of 25-hydroxyvitamin D due to impairment of the hydroxylating enzyme CYP2R1 in the testis. However, no data have been published dealing with the best treatment option (cholecalciferol - the Vitamin D precursor, or calcidiol - 25-hydroxylated form of Vitamin D in these patients. We studied 66 patients with classic hypogonadism (total T [TT] <12 nmol l−1 , LH ≥ 8 IU l−1 (n = 26 and subclinical hypogonadism (TT ≥ 12 nmol l−1 , LH ≥ 8 IU l−1 (n = 40 and low 25-hydroxyvitamin D (<50 nmol l−1 . Subjects received cholecalciferol (5000 IU per week (n = 20 or calcidiol (4000 IU per week (n = 46, and 25-hydroxyvitamin D and parathyroid hormone (PTH were evaluated after 3 months of therapy. Supplementation with calcidiol significantly increased 25-hydroxyvitamin D and significantly decreased PTH levels in both groups of men with hypogonadism (primary, n = 16 and subclinical, n = 30, whereas supplementation with cholecalciferol did not modify their levels. This study shows for the first time that the administration of the 25-hydroxylated form of Vitamin D (calcidiol, and not the administration of the precursor cholecalciferol, restores 25-hydroxyvitamin D levels in subjects with hypogonadism.

  17. Suicide and euthanasia in late life.

    Science.gov (United States)

    De Leo, Diego; Spathonis, Kym

    2003-04-01

    Epidemiological studies of suicide in the elderly indicate that, in the last few decades, there has been a relevant increase in suicide rates in old age in a number of Asian and Latin nations, with an almost parallel decrease in Anglo-Saxon counties. Mental disorders, particularly depression, physical illness, personality traits such as hostility, hopelessness, the inability to verbally express psychological pain and dependency on others, recent life events and losses are all factors that may contribute to suicide in later life. Compared with suicide in other age groups, mors voluntaris in late life is associated with the use of highly lethal methods, less ambivalence and impulsivity, and more determination and intent to die. Accordingly, elderly suicidal individuals are more likely than younger subjects to complete rather than attempt suicide. Some evidence suggests also that the characteristics of elderly individuals who attempt suicide may not overlap with those who complete suicide. Death thoughts and suicidal ideations are relatively rare among mentally healthy elderly adults, and are less predominant in this age bracket. However, whether elderly suicidal behaviour exists along a continuum, progressing in severity from death thoughts and suicidal ideation to suicide attempts and completed suicide, remains unclear. Assisted suicide and euthanasia in the elderly have been associated with the desire to escape chronic physical pain and suffering caused by terminal illness, and to relieve mental anguish and feelings of hopelessness, depression and extreme "tiredness of life." The role of the family and those treating chronically ill members is crucial in the final stages of life, particularly when autonomy and the ability of the elderly individual to make end-of-life decisions are compromised. The main aspects associated with these controversial phenomena, particularly from a transcultural perspective, are reviewed in this article.

  18. Late-modern transformation of Islam or Islamic transformation of Late-modern Religiosity?

    DEFF Research Database (Denmark)

    Riexinger, Martin Thomas

    2017-01-01

    The Turkish author Muhammed Bozdağ, who has no formal religious education, has been popular since the late 1990s because of his self-help seminars and self-help books. Though they are based on the adaptation of Western New Age-inspired models, Bozdağ uses many of the models’ parascientific concep...... in parascientific terms. The strong emphases on collective normativity and on a theistic worldview clearly characterize his adaption of elements from new religiosities as highly selective and restricted to very specific purposes....

  19. Late Pleistocene dune activity in the central Great Plains, USA

    Science.gov (United States)

    Mason, J.A.; Swinehart, J.B.; Hanson, P.R.; Loope, D.B.; Goble, R.J.; Miao, X.; Schmeisser, R.L.

    2011-01-01

    Stabilized dunes of the central Great Plains, especially the megabarchans and large barchanoid ridges of the Nebraska Sand Hills, provide dramatic evidence of late Quaternary environmental change. Episodic Holocene dune activity in this region is now well-documented, but Late Pleistocene dune mobility has remained poorly documented, despite early interpretations of the Sand Hills dunes as Pleistocene relicts. New optically stimulated luminescence (OSL) ages from drill cores and outcrops provide evidence of Late Pleistocene dune activity at sites distributed across the central Great Plains. In addition, Late Pleistocene eolian sands deposited at 20-25 ka are interbedded with loess south of the Sand Hills. Several of the large dunes sampled in the Sand Hills clearly contain a substantial core of Late Pleistocene sand; thus, they had developed by the Late Pleistocene and were fully mobile at that time, although substantial sand deposition and extensive longitudinal dune construction occurred during the Holocene. Many of the Late Pleistocene OSL ages fall between 17 and 14 ka, but it is likely that these ages represent only the later part of a longer period of dune construction and migration. At several sites, significant Late Pleistocene or Holocene large-dune migration also probably occurred after the time represented by the Pleistocene OSL ages. Sedimentary structures in Late Pleistocene eolian sand and the forms of large dunes potentially constructed in the Late Pleistocene both indicate sand transport dominated by northerly to westerly winds, consistent with Late Pleistocene loess transport directions. Numerical modeling of the climate of the Last Glacial Maximum has often yielded mean monthly surface winds southwest of the Laurentide Ice Sheet that are consistent with this geologic evidence, despite strengthened anticyclonic circulation over the ice sheet. Mobility of large dunes during the Late Pleistocene on the central Great Plains may have been the result of

  20. Sirtinol abrogates late phase of cardiac ischemia preconditioning in rats.

    Science.gov (United States)

    Safari, Fereshteh; Shekarforoosh, Shahnaz; Hashemi, Tahmineh; Namvar Aghdash, Simin; Fekri, Asefeh; Safari, Fatemeh

    2016-09-27

    The aim of this study was to investigate the effect of sirtinol, as an inhibitor of sirtuin NAD-dependent histone deacetylases, on myocardial ischemia reperfusion injury following early and late ischemia preconditioning (IPC). Rats underwent sustained ischemia and reperfusion (IR) alone or proceeded by early or late IPC. Sirtinol (S) was administered before IPC. Arrhythmias were evaluated based on the Lambeth model. Infarct size (IS) was measured using triphenyltetrazolium chloride staining. The transcription level of antioxidant-coding genes was assessed by real-time PCR. In early and late IPC groups, IS and the number of arrhythmia were significantly decreased (P IPC, incidences of arrhythmia and IS were not different compared with the early IPC group. However, in S + late IPC the IS was different from the late IPC group (P IPC but not early IPC, transcription levels of catalase (P IPC group. Our results are consistent with the notion that different mechanisms are responsible for early and late IPC. In addition, sirtuin NAD-dependent histone deacetylases may be implicated in late IPC-induced cardioprotection.

  1. Parapneumonic pleural effusion: early versus late thoracoscopy.

    Science.gov (United States)

    Pereira, Rodrigo Romualdo; Alvim, Cristina Gonçalves; Andrade, Cláudia Ribeiro de; Ibiapina, Cássio da Cunha

    2017-07-31

    To evaluate the best time to perform thoracoscopy for the treatment of complicated parapneumonic pleural effusion in the fibrinopurulent phase in patients ≤ 14 years of age, regarding the postoperative evolution and occurrence of complications. This was a retrospective comparative study involving patients with parapneumonic pleural effusion presenting with septations or loculations on chest ultrasound who underwent thoracoscopy between January of 2000 and January of 2013. The patients were divided into two groups: early thoracoscopy (ET), performed by day 5 of hospitalization; and late thoracoscopy (LT), performed after day 5 of hospitalization. We included 60 patients, 30 in each group. The mean age was 3.4 years; 28 patients (46.7%) were male; and 47 (78.3%) underwent primary thoracoscopy (no previous simple drainage). The two groups were similar regarding gender, age, weight, and type of thoracoscopy (p > 0.05 for all). There was a significant difference between the ET and the LT groups regarding the length of the hospital stay (14.5 days vs. 21.7 days; p sexo masculino, e 47 (78,3%) foram submetidos à toracoscopia primária, sem realização de drenagem simples prévia. Os grupos TP e TT foram semelhantes quanto ao sexo, idade, peso e tipo de toracoscopia (p > 0,05 para todos). Observou-se uma diferença significativa quanto à média de duração da internação nos grupos TP e TT (14,5 dias vs. 21,7 dias; p < 0,001). Houve também diferenças significativas entre os grupos quanto ao total de dias com febre, total de dias entre internação e início da drenagem e total de dias com dreno. Oito pacientes (13,6%) apresentaram alguma complicação após a toracoscopia, sem diferença entre os grupos. Não houve óbitos. A TP, realizada até o 5º dia da admissão hospitalar, associou-se a menor duração da internação, menor tempo de drenagem e menor duração da febre, sem estar associada a maior frequência de complicações, necessidade de CTI ou

  2. Late Holocene Andesitic Eruptions at Mount Rainier

    Science.gov (United States)

    Sisson, T. W.; Vallance, J. W.

    2005-12-01

    -hydromagmatic eruptions. Mt. Rainier's late Holocene activity was typified by repeated arrival and eruption of slightly different andesitic magmas. Most eruptions were effusions of largely degassed magma, accompanied by near-surface explosions that blanketed the proximal region with fine-grained glassy ash. Associated rapidly ascended magma led to sparse pumice, pyroclastic flows, or plinian tephra fall, depending on amount.

  3. Late Pennsylvanian climate changes and palynomorph extinctions

    Science.gov (United States)

    Kosanke, R.M.; Cecil, C.B.

    1996-01-01

    A major floral change occurs in the Upper Pennsylvanian strata in the Midcontinent, Illinois basin, and in the northern Appalachian basin of eastern United States. Lycospora spp. (derived from arborescent lycopsids) became extinct along with some other palynomorph taxa. This investigation is concerned with the importance of this major floral change. Samples were studied from western Pennsylvania, eastern Ohio, and West Virginia (from a previous study) cover the stratigraphic interval from the Upper Freeport coal bed, uppermost part of the Allegheny Formation, to the Mahoning, Mason, Brush Creek, Wilgus, and Anderson coal beds in the lower part of the Conemaugh Formation. The floral change occurs either at or below the accepted Desmoinesian-Missourian boundary in the Midcontinent and Illinois basin, whereas in the northern Appalachians this change occurs in the lower part of the Conemaugh Formation, between the Mahoning and Brush Creek coal beds, or when the Mason is present, between the Mahoning and Mason coal beds. With the advent of late Middle Pennsylvanian time, the climate began to change from wet tropical to seasonal tropical. The Middle-Upper Pennsylvanian boundary is the culmination of this drying trend, which was marked by reduction of available water. The peat swamps are interpreted as having changed from the domed type of bog to the planar type under these circumstances. Thus, in general, the coals of the Conemaugh Formation are characteristically much thinner than those of the Allegheny Formation. This was caused by a number of factors including reduced or more seasonal rainfall, decline of arborescent lycopsids, and the increased dominance of herbaceous and fern plants. As a result, there are fewer minable coal beds in the Conemaugh Formation. The first coal bed above the extinction of Lycospora spp. is dominated by the palynomorph taxon Endosporites globiformis which is derived from a heterosporous, herbaceous lycopsid. However, Sigillaria, another

  4. Late Miocene Tidal Deposits in the Amazonian Foreland Basin

    Science.gov (United States)

    Rasanen, Matti E.; Linna, Ari M.; Santos, Jose C. R.; Negri, Francisco R.

    1995-07-01

    Late Miocene tidal sediments of Acre, Brazilian Amazonia, were deposited in an embayment or interior seaway located in the sub-Andean zone. This late Tertiary embayment system may once have connected the Caribbean with the South Atlantic. The tidal coasts of the embayment-seaway have provided an avenue for the earliest waif (over water) dispersal phases of the great American biotic interchange in the late Miocene. The subsequent change from semimarine to terrestrial environments is of value in assessing the importance of earlier hypotheses on the evolution of the western Amazonian landscape and gives insight into the formation of several observed biogeographic patterns, especially of aquatic biota.

  5. Late-Onset Rash Associated with Lamotrigine: Case Report

    Directory of Open Access Journals (Sweden)

    Raquel Ribeiro

    2014-10-01

    Full Text Available The use of lamotrigine in Bipolar Disorder has been approved by the F.D.A since 2003. Rash is the more frequent adverse effect related to the treatment with Lamotrigine and in several cases is the cause for discontinuation of medical treatment. The less frequent related cases of rash are the late onset ones. About a women’s case with a late onset of rash, we revised the clinical use of Lamotrigine in Bipolar Disorder published bibliography which is followed by a special focus in the rash itself and finally we present some particular issues about late onset rash.

  6. An exhumed Late Paleozoic canyon in the rocky mountains

    Science.gov (United States)

    Soreghan, G.S.; Sweet, D.E.; Marra, K.R.; Eble, C.F.; Soreghan, M.J.; Elmore, R.D.; Kaplan, S.A.; Blum, M.D.

    2007-01-01

    Landscapes are thought to be youthful, particularly those of active orogenic belts. Unaweep Canyon in the Colorado Rocky Mountains, a large gorge drained by two opposite-flowing creeks, is an exception. Its origin has long been enigmatic, but new data indicate that it is an exhumed late Paleozoic landform. Its survival within a region of profound late Paleozoic orogenesis demands a reassessment of tectonic models for the Ancestral Rocky Mountains, and its form and genesis have significant implications for understanding late Paleozoic equatorial climate. This discovery highlights the utility of paleogeomorphology as a tectonic and climatic indicator. ?? 2007 by The University of Chicago. All rights reserved.

  7. Late Globalization and Evolution, Episodes and Epochs of Industries

    DEFF Research Database (Denmark)

    Turcan, Romeo V.; Boujarzadeh, Behnam; Dholakia, Nikhilesh

    While the empirical focus of this paper is the Danish Textile and Fashion Industry (DTFI) – specifically the episodes and epochs in the emergence and evolution of DTFI, in essence the micro and macro time-slices – the theoretical intent is wider. We aim to explore the conceptual terrain of what we...... term “late globalization”, a terrain that has temporal and spatial aspects along with many other dimensions. DTFI as a late globalizer with its specific pattern, with ups and downs as well as innovations and adaptations, provides a specific window into late globalization processes; and sets a stage...

  8. Late Variscan deformation in the Iberian Peninsula; a late feature in the Laurentia-Gondwana dextral collision

    Science.gov (United States)

    Dias, R.; Moreira, N.; Ribeiro, A.; Basile, C.

    2017-03-01

    The Late Variscan deformation event in Iberia is characterized by an intraplate deformation regime induced by the dextral oblique collision between Laurentia and Gondwana. This episode in Iberia is characterized by NNE-SSW brittle to brittle-ductile strike-slip faults, which are considered by the classic works as sinistral strike-slip faults. However, the absence of Mesozoic formations constraining the age of this sinistral kinematics led some authors to consider it as the result of Alpine reworking. Structural studies in Almograve and Ponta Ruiva sectors (SW Portugal) show that NNE-SSW faults have a sinistral kinematics and are occasionally associated with E-W dextral shears. Moreover, this kinematics is related to the late deformation episodes of Variscan orogeny. In Almograve sector, the Late Variscan structures are characterized by NNE-SSW sinistral kink bands, spatially associated with E-W dextral faults. These structures are contemporaneous and affect the previously deformed Carboniferous units. The Ponta Ruiva Sector constrains the age of deformation because the E-W dextral shears affect the Late Carboniferous (late Moscovian) units, but not the overlying Triassic series. The new data show that the NNE-SSW and the E-W faults are dynamically associated and result from the Late Variscan deformation episode. The NNE-SSW sinistral faults could be considered as second-order domino structures related to first-order E-W dextral shears, linked to Laurentia-Gondwana collision during Late Carboniferous-Permian times.

  9. Prevalence and associated factors of late HIV diagnosis in north ...

    African Journals Online (AJOL)

    User

    This study aimed to determine the prevalence and associated factors ..... defining illnesses including, chronic diarrhea, esophageal and oral Candidiasis and recurrent upper .... "Predictors of Late HIV Diagnosis among Adult People Living.

  10. Zika Virus Can Damage Fetal Brain Late in Pregnancy: Study

    Science.gov (United States)

    ... https://medlineplus.gov/news/fullstory_161451.html Zika Virus Can Damage Fetal Brain Late in Pregnancy: Study ... WEDNESDAY, Oct. 12, 2016 (HealthDay News) -- The Zika virus may harm a baby's brain even if the ...

  11. Toward late career transitioning: a proposal for academic surgeons.

    Science.gov (United States)

    Richards, Robin; McLeod, Robin; Latter, David; Keshavjee, Shaf; Rotstein, Ori; Fehlings, Michael G; Ahmed, Najma; Nathens, Avery; Rutka, James

    2017-08-01

    In the absence of a defined retirement age, academic surgeons need to develop plans for transition as they approach the end of their academic surgical careers. The development of a plan for late career transition represents an opportunity for departments of surgery across Canada to initiate a constructive process in cooperation with the key stakeholders in the hospital or institution. The goal of the process is to develop an individual plan for each faculty member that is agreeable to the academic surgeon; informs the surgical leadership; and allows the late career surgeon, the hospital, the division and the department to make plans for the future. In this commentary, the literature on the science of aging is reviewed as it pertains to surgeons, and guidelines for late career transition planning are shared. It is hoped that these guidelines will be of some value to academic programs and surgeons across the country as late career transition models are developed and adopted.

  12. Intracranial hemorrhages and late hemorrhagic disease associated cholestatic liver disease.

    Science.gov (United States)

    Per, Hüseyin; Arslan, Duran; Gümüş, Hakan; Coskun, Abdulhakim; Kumandaş, Sefer

    2013-01-01

    Deficiency of vitamin K predisposes to early, classic or late hemorrhagic disease of the newborn (HDN); of which late HDN may be associated with serious and life-threatening intracranial hemorrhage. Late HDN is characterized intracranial bleeding in infants aged 1 week to 6 months due to severe vitamin K deficiency. Late HDN is still an important cause of mortality and morbidity in developing countries where vitamin K prophylaxis is not routinely practiced. Children with cholestatic liver disease are at risk for developing secondary vitamin K deficiency because of fat malabsorbtion and inadequate dietary intake. In this study, we described 11 infants with cholestatic liver disease with different etiologies exhibiting intracranial hemorrhage (ICH). Six patients underwent surgical evacuation of ICH, following the administration of vitamin K and/or fresh frozen plasma. The possibility of cholestatic liver disease should be considered in the treatment of ICH due to vitamin K deficiency.

  13. NIH Blood and Marrow Transplant Late Effects Consensus Conference

    Science.gov (United States)

    This day and a half symposium will bring together experts in blood and marrow transplantation, late effects, and health care delivery to discuss current evidence and knowledge gaps, develop consensus guidelines, and inform future research in the BMT survivor population.

  14. Traditional medicine in late pregnancy and labour: perceptions of ...

    African Journals Online (AJOL)

    Traditional medicine in late pregnancy and labour: perceptions of kgaba remedies ... believed to cause foetal distress and an increase in caesarean sections. ... The use of crushed ostrich eggshell, which is perceived as inducing labour, ...

  15. Management of Tomato Late Blight Disease Using Reduced ...

    African Journals Online (AJOL)

    Results reveal that, variety Meru was resistant to tomato late blight disease while, Cal-J and Tanya varieties were highly ... for human health and environmental risks associated .... grasshoppers, whiteflies, aphids and caterpillars at the dosage ...

  16. Massive Neurofibroma of the Breast: Late Presentation in a Low ...

    African Journals Online (AJOL)

    Valued eMachines Customer

    It exemplifies a disease presenting late in its natural history, typical of patients seeking medical care in low resource countries. Key words: Neurofibroma ... Neurofibromas of the breast are classified in two types; dermal and plexiform. Dermal ...

  17. Intracranial hemorrhage due to late hemorrhagic disease in two siblings.

    Science.gov (United States)

    Per, Hüseyin; Kumandaş, Sefer; Ozdemir, Mehmet Akif; Gümüş, Hakan; Karakukcu, Musa

    2006-07-01

    Deficiency of vitamin K predisposes to early, classic or late hemorrhagic disease of the newborn (HDN); late HDN may be associated with serious and life-threatening intracranial hemorrhage. Late HDN is characterized by intracranial bleeding in infants aged 1 week to 6 months due to severe vitamin K deficiency, occurring particularly in exclusively breastfed infants. Late HDN is still an important cause of mortality and morbidity in developing countries where vitamin K prophylaxis is not routinely practiced. In this study, we report on two siblings with intracranial bleeding who were fully breastfed without a routine supplementation of vitamin K. Vitamin K should be given to all newborns as a single, intramuscular dose of 1 mg.

  18. An unusual case of late ocular changes after lightning injury.

    Directory of Open Access Journals (Sweden)

    Datta Himadri

    2002-01-01

    Full Text Available We describe a case of late ocular changes after lightning injury. One year after the injury, complete ankyloblepharon, severe dry eye, corneal opacity, healed iritis and mature cataracts were noted in both eyes of the patient.

  19. Effect of insecticide application on pests of late maturing pigeonpea ...

    African Journals Online (AJOL)

    Effect of insecticide application on pests of late maturing pigeonpea cultivar ... University of Nigeria, Nsukka agro-ecological zone in 2000/2001 cropping season. ... control of pigoenpea pests under the integrated management concept.

  20. Late Pleistocene potential distribution of the North African sengi or ...

    African Journals Online (AJOL)

    Late Pleistocene potential distribution of the North African sengi or ... origin for an extant species, predating the dramatic climatic fluctuations of the Pleistocene. ... occurrence points to develop models of present-day potential distributions of E.

  1. Patriarch Ephrem: A late medieval saintly cult

    Directory of Open Access Journals (Sweden)

    Popović Danica

    2006-01-01

    Full Text Available Patriarch Ephrem, monk and hermit, writer and saint, Bulgarian-born but twice the leader of the Serbian Church (1375-78 and 1389-92, is an outstanding figure of the late medieval Balkans. His "life and works" are discussed here in the light of hagiological texts and the information provided by various types of sources with the view to drawing some historically relevant conclusions. The main source of information about Ephrem's life and activity are the eulogies, Life and service composed by bishop Mark, his disciple and loyal follower for twenty-three years. Making use of hagiographical topica combined with plentiful data of undoubted documentary value, he relates the story of Ephrem's life through all of its major stages: from his birth and youth to his withdrawal from the world and taking of a monk's habit. Of formative influence were his years on the Holy Mount Athos, where he experienced different styles of monastic life, coenobitic, as well as solitary, which he practiced in the well-known hermitages in the heights of Athos. The further course of Ephrem's life was decided by the turbulent developments in the Balkans brought about by the Ottoman conquests. In that sense, his biography, full of forced and voluntary resettlements, is a true expression of the spirit of the times. Forced to flee Mount Athos, Ephrem made a short stay in Bulgaria and then, about 1347, came to Serbia, where he spent the rest of his life. An eminent representative of the monastic elite and under the aegis of the Serbian patriarch, he spent ten years in a hesychastria of the Monastery of Decani. For reasons of security, he then moved to a cave hermitage founded specially for him in the vicinity of the Patriarchate of Pec. It was in that cell, where he lived for twenty years powerfully influencing the monastic environment, that his literary work profoundly marked by hesychast thought and eschatology, was created. Ephrem twice accepted the office of patriarch in the

  2. Late Cretaceous Volcaniclastics in NW Turkey

    Science.gov (United States)

    Boehm, Katharina; Wolfgring, Erik; Omer Yilmaz, Ismail; Tüysüz, Okan; Wagreich, Michael

    2015-04-01

    and the following rifting and opening of the western and eastern Black Sea basin. The existence of a Pontide magmatic arc, as referred to in literature, is not precluded by the back-arc interpretation and should be further looked at, as geochemistry confirms a volcanic arc setting. Correlation of the volcaniclastics with biostratigraphic events and ages from the same outcrops refers to a relative time span between Turonian and Campanian when the magmatic arc was active, at least. Further this correlation contributes to connecting particular outcrops with Dereköy or Cambu Formation. Consequently using these results Cambu Formation can be assigned as less alkaline and acidic then the lower volcanic succession. Furthermore the volcanic series seem to be more tholeiitic in the upper volcanic succession. Generally samples belonging to the Dereköy Formation are enriched in Zr, Th and Nb with respect to samples of Cambu formation. The volcanic arc setting and the chemical characteristics of the volcanism, traced along the southwestern Black Sea coast as distinct tuff layers, are interesting mosaics in understanding paleogeography and paleoenvironmental changes in the Late Cretaceous.

  3. Late Archean Surface Ocean Oxygenation (Invited)

    Science.gov (United States)

    Kendall, B.; Reinhard, C.; Lyons, T. W.; Kaufman, A. J.; Anbar, A. D.

    2009-12-01

    Oxygenic photosynthesis must have evolved by 2.45-2.32 Ga, when atmospheric oxygen abundances first rose above 0.001% present atmospheric level (Great Oxidation Event; GOE). Biomarker evidence for a time lag between the evolution of cyanobacterial oxygenic photosynthesis and the GOE continues to be debated. Geochemical signatures from sedimentary rocks (redox-sensitive trace metal abundances, sedimentary Fe geochemistry, and S isotopes) represent an alternative tool for tracing the history of Earth surface oxygenation. Integrated high-resolution chemostratigraphic profiles through the 2.5 Ga Mt. McRae Shale (Pilbara Craton, Western Australia) suggest a ‘whiff’ of oxygen in the surface environment at least 50 M.y. prior to the GOE. However, the geochemical data from the Mt. McRae Shale does not uniquely constrain the presence or extent of Late Archean ocean oxygenation. Here, we present high-resolution chemostratigraphic profiles from 2.6-2.5 Ga black shales (upper Campbellrand Subgroup, Kaapvaal Craton, South Africa) that provide the earliest direct evidence for an oxygenated ocean water column. On the slope beneath the Campbellrand - Malmani carbonate platform (Nauga Formation), a mildly oxygenated water column (highly reactive iron to total iron ratios [FeHR/FeT] ≤ 0.4) was underlain by oxidizing sediments (low Re and Mo abundances) or mildly reducing sediments (high Re but low Mo abundances). After drowning of the carbonate platform (Klein Naute Formation), the local bottom waters became anoxic (FeHR/FeT > 0.4) and intermittently sulphidic (pyrite iron to highly reactive iron ratios [FePY/FeHR] > 0.8), conducive to enrichment of both Re and Mo in sediments, followed by anoxic and Fe2+-rich (ferruginous) conditions (high FeT, FePY/FeHR near 0). Widespread surface ocean oxygenation is suggested by Re enrichment in the broadly correlative Klein Naute Formation and Mt. McRae Shale, deposited ~1000 km apart in the Griqualand West and Hamersley basins

  4. Psychiatry: life events and social support in late life depression

    Directory of Open Access Journals (Sweden)

    Clóvis Alexandrino-Silva

    2011-01-01

    Full Text Available OBJECTIVES: To examine the association of life events and social support in the broadly defined category of depression in late life. INTRODUCTION: Negative life events and lack of social support are associated with depression in the elderly. Currently, there are limited studies examining the association between life events, social support and late-life depression in Brazil. METHODS: We estimated the frequency of late-life depression within a household community sample of 367 subjects aged 60 years or greater with associated factors. ''Old age symptomatic depression'' was defined using the Composite International Diagnostic Interview 1.1 tool. This diagnostic category included only late-life symptoms and consisted of the diagnoses of depression and dysthymia as well as a subsyndromal definition of depression, termed ''late subthreshold depression''. Social support and life events were assessed using the Comprehensive Assessment and Referral Evaluation (SHORT-CARE inventory. RESULTS: ''Old age symptomatic depression'' occurred in 18.8% of the patients in the tested sample. In univariate analyses, this condition was associated with female gender, lifetime anxiety disorder and living alone. In multivariate models, ''old age symptomatic depression'' was associated with a perceived lack of social support in men and life events in women. DISCUSSION: Social support and life events were determined to be associated with late-life depression, but it is important to keep in mind the differences between genders. Also, further exploration of the role of lifetime anxiety disorder in late-life depression may be of future importance. CONCLUSIONS: We believe that this study helps to provide insight into the role of psychosocial factors in late-life depression.

  5. A theropod tooth from the Late Triassic of southern Africa

    Indian Academy of Sciences (India)

    Sanghamitra Ray; Anusuya Chinsamy

    2002-06-01

    An isolated, large recurved and finely serrated tooth found associated with the prosauropod Euskelosaurus from the Late Triassic part of the Elliot Formation is described here. It is compared to the Triassic thecodonts and carnivorous dinosaurs and its possible affinity is discussed. The tooth possibly belongs to a basal theropod and shows some features similar to the allosauroids. This tooth is of significance, as dinosaur remains except for some footprints and trackways, are poorly known in the Late Triassic horizons of southern Africa.

  6. Late opacification of a hydrophilic acrylic intraocular lens

    Directory of Open Access Journals (Sweden)

    Al-Bdour Muawyah

    2008-01-01

    Full Text Available Cataract extraction and intraocular lens implantation is considered to be a safe procedure in most cases. However, the new advances in the surgical technique namely phacoemulsification and hence the increased use of foldable intraocular lenses have given rise to new complications including late opacification of intraocular lenses. In this case we report late opacification of a foldable hydrophilic acrylic intraocular lens and the surgical technique for its exchange.

  7. Late onset seroma post-thymectomy presenting as cardiac tamponade

    OpenAIRE

    Poudel, Dilli Ram; Giri, Smith; Pathak, Ranjan; Morsey, Mohamed; Alsafwah, Shadwan

    2015-01-01

    Late onset seroma is a rare post-operative complication occurring after various surgeries including thymectomy. Most cases are asymptomatic; however, seromas occurring in the mediastinal cavity may cause compression symptoms including airway compression or cardiac tamponade. We present a 62-year-old male with a history of thymectomy for myasthenia gravis who presented with cardiac tamponade several years ago. Further evaluation revealed a late onset seroma anteriorly compressing the cardiac c...

  8. Late-time spectroscopy of Type Iax Supernovae

    Science.gov (United States)

    Foley, Ryan J.; Jha, Saurabh W.; Pan, Yen-Chen; Zheng, Wei Kang; Bildsten, Lars; Filippenko, Alexei V.; Kasen, Daniel

    2016-09-01

    We examine the late-time (t ≳ 200 d after peak brightness) spectra of Type Iax supernovae (SNe Iax), a low-luminosity, low-energy class of thermonuclear stellar explosions observationally similar to, but distinct from, Type Ia supernovae. We present new spectra of SN 2014dt, resulting in the most complete late-time spectral sequence of an SN Iax. At late times, SNe Iax have generally similar spectra, all with a similar continuum shape and strong forbidden-line emission. However, there is also significant diversity where some SN Iax spectra display narrow P-Cygni features from permitted lines and a continuum indicative of a photosphere at late times in addition to strong narrow (FWHM 6000 km s-1) forbidden lines, and weak narrow forbidden lines, and some SNe Iax have spectra intermediate to these two varieties. We find that SNe Iax with strong broad forbidden lines are more luminous and have higher velocity ejecta at peak brightness. We estimate blackbody and kinematic radii of the late-time photosphere, finding the latter significantly larger than the former. We propose a two-component model that solves this discrepancy and explains the diversity of the late-time spectra of SNe Iax. In this model, the broad forbidden lines originate from the SN ejecta, while the photosphere, P-Cygni lines, and narrow forbidden lines originate from a wind launched from the remnant of the progenitor white dwarf and is driven by the radioactive decay of newly synthesized material left in the remnant. The relative strength of the two components accounts for the diversity of late-time SN Iax spectra. This model also solves the puzzle of a long-lived photosphere and the slow late-time decline of SNe Iax.

  9. Predictors of future depression in early and late adolescence.

    Science.gov (United States)

    van Lang, Natasja D J; Ferdinand, Robert F; Verhulst, Frank C

    2007-01-01

    This study examined whether the possibility to predict future DSM-IV depressive disorder can be increased with recurrent screening for depression in community adolescents, compared to single screening in early or in late adolescence. In addition, it examined which depressive symptoms in early and late adolescence predicted future depressive disorder most accurately. Participants from an ongoing longitudinal cohort study were assessed when they were aged between 10 and 15 (early adolescence), and between 14 and 19 (late adolescence), and were followed until they were 20-25 (young adulthood). The Child Behavior Checklist (CBCL) and Youth Self-Report (YSR) were used to screen for depression in early and late adolescence, and CIDI/DSM-IV diagnoses of depressive disorder were used as the outcome measure during follow-up. Recurrent screening only slightly improved the prediction of future depression, and cognitive and physical symptoms in late adolescence predicted future depression accurately in boys. Sleeping problems in early adolescence predicted future depression in girls. The main limitation was the retrospective recall of the age of onset of a depressive disorder. Recurrent screening for depression did not predict future depressive disorder better than single screening in late adolescence. However, depressive symptoms like sleeping problems predicted future depression quite accurately in adolescent boys and girls. This indicates that it may be useful to screen adolescents for the presence of such symptoms, for instance in school settings, to predict which adolescents are at risk to develop DSM-IV depressive disorder in early adulthood.

  10. Prognostic value of late heart rate recovery after treadmill exercise.

    Science.gov (United States)

    Johnson, Nils P; Goldberger, Jeffrey J

    2012-07-01

    Recovery from exercise can be divided into an early, rapid period and a late, slower period. Although early heart rate (HR) recovery 1 minute after treadmill exercise independently predicts survival, the prognostic value of late HR recovery has not been well studied. The aim of this study was to evaluate the independent prognostic value of late HR recovery for all-cause mortality. A total of 2,082 patients referred to the nuclear cardiology laboratory of an urban academic medical center for treadmill exercise with imaging from August 1998 to December 2003 were followed for all-cause mortality. During 9.9 ± 1.5 years of follow-up, 196 deaths (9%) occurred. To avoid overlap with early HR recovery or the baseline HR, late HR recovery was defined as the percentage of the cycle length change between rest and peak exercise that had been recovered after 5 minutes. Lower values represent impaired recovery, by analogy with 1-minute HR recovery. Impaired late HR recovery was a significant univariate predictor of all-cause mortality (hazard ratio 0.28 per percentage, 95% confidence interval 0.17 to 0.46, p recovery, with independent prognostic value (adjusted hazard ratio 0.58, 95% confidence interval 0.41 to 0.84, p = 0.004). In conclusion, late HR recovery after treadmill exercise stress adds prognostic value for all-cause mortality to a multivariate model including early, 1-minute HR recovery.

  11. Reaction of peanut cultivars to late leafspot and rust

    Directory of Open Access Journals (Sweden)

    Nimitr Vorasoot

    2003-05-01

    Full Text Available Late leafspot caused by Phaeoisariopsis personata (Berk. & M.A. Curtis van Arx and rust caused by Puccinia arachidis Speg. are among the most serious diseases of peanut. Although fungicide application is effective in controlling the diseases, its high cost is considered uneconomical in many developing countries. In this situation, the use of resistant cultivars offers a better alternative. The objective of this study was to evaluate seven peanut cultivars for their resistances to late leafspot and rust. Peanut cultivars were planted in a randomized complete block design (RCBD with 4 replications at Khon Kaen University Experimental Farm. Natural infection of late leafspot and rust were allowed. Disease score, sporulation index and lesion number per 100 cm2 of leaf area were recorded as the resistance parameters of both diseases. Pod yield, seed yield, shelling percentage, pod number per plant and pod length were also measured. NC 17135 was the most resistant to late leafspot and moderately resistant to rust. NC 17090 was the most resistant to rust but susceptible to late leafspot. NC 17135 and NC 17090 should be recommended as sources of late leafspot and rust resistance, respectively. The two Thai released cultivars, Tainan 9 and Lampang were highly susceptible to both diseases.

  12. Neuroimaging findings in late-onset schizophrenia and bipolar disorder.

    Science.gov (United States)

    Hahn, Changtae; Lim, Hyun Kook; Lee, Chang Uk

    2014-03-01

    In recent years, there has been an increasing interest in late-onset mental disorders. Among them, geriatric schizophrenia and bipolar disorder are significant health care risks and major causes of disability. We discussed whether late-onset schizophrenia (LOS) and late-onset bipolar (LOB) disorder can be a separate entity from early-onset schizophrenia (EOS) and early-onset bipolar (EOB) disorder in a subset of late-life schizophrenia or late-life bipolar disorder through neuroimaging studies. A literature search for imaging studies of LOS or LOB was performed in the PubMed database. Search terms used were "(imaging OR MRI OR CT OR SPECT OR DTI OR PET OR fMRI) AND (schizophrenia or bipolar disorder) AND late onset." Articles that were published in English before October 2013 were included. There were a few neuroimaging studies assessing whether LOS and LOB had different disease-specific neural substrates compared with EOS and EOB. These researches mainly observed volumetric differences in specific brain regions, white matter hyperintensities, diffusion tensor imaging, or functional neuroimaging to explore the differences between LOS and LOB and EOS and EOB. The aim of this review was to highlight the neural substrates involved in LOS and LOB through neuroimaging studies. The exploration of neuroanatomical markers may be the key to the understanding of underlying neurobiology in LOS and LOB.

  13. Late and very-late first-contact schizophrenia and the risk of dementia--a nationwide register based study

    DEFF Research Database (Denmark)

    Kørner, Alex; Lopez, Ana Garcia; Lauritzen, Lise

    2009-01-01

    diagnosis of dementia for each individual at discharge or at out-patient contact was established. The probability of getting a dementia diagnosis is estimated using Poisson regression models with dementia as the outcome of interest. RESULTS: Twelve thousand six hundred and sixteen and 7,712 individuals were...... included in the late and very-late sample, respectively. Follow-up time was between 3.00 and 4.58 years. The rate ratio (RR) of developing dementia in late and very-late first-contact schizophrenia compared to osteoarthritis patients were 3.47 (95%CI: 2.19-5.50) and 3.15 (95%CI: 1.93-5.14), respectively...

  14. Late Effects Following Treatment of Hodgkin Lymphoma During Childhood and Adolescence. Results of the Hodgkin Lymphoma Late Effects Research Project.

    Science.gov (United States)

    Dörffel, W; Riepenhausen, M; Lüders, H; Brämswig, J

    2016-11-01

    Survival rates have been excellent in patients treated for Hodgkin lymphoma (HL) during childhood and adolescence. Unfortunately, severe treatment related late effects have been observed. It was therefore an important aim of the cooperative pediatric HL therapy studies in Germany to reduce the number of late effects without jeopardizing the excellent treatment results. Progress and relapses of HL were analyzed to obtain important information for the future salvage therapy. All late effects were documented and their etiologies analyzed. Information obtained from bacterial infections and late deaths following splenectomy were used to inform patients at risk and their local physicians about necessary preventive measurements. Procarbazine was recognized as major gonadotoxic agent in boys and eliminated successively from the treatment regimens. Parenthood was normal in female patients when compared to the German female population documenting normal ovarian function except in patients with pelvic radiation. Radiation was the most important risk factor for thyroid diseases, cardiac late effects and subsequent malignant neoplasms, especially thyroid and breast cancer. A special screening program was initiated for women with chest radiotherapy, since they had a high risk of breast cancer already at a young age. The results of the HL Late Effects Research Project are important for the aftercare of patients and for the design of future HL treatment regimens.

  15. [Chronic hallucinatory psychosis and late onset schizophrenia: the same entity?].

    Science.gov (United States)

    Dubertret, C; Gorwood, P; Adès, J

    1997-01-01

    The distinction between schizophrenia and chronic delusion syndromes (such as paraphrenia, late-paraphrenia and "Psychose Hallucinatoire Chronique") is currently used in France, although there is no international criteria (ICD 10 or DSM IV) for chronic delusion syndromes. It is thus worth analysing the literature in order to compare the differences between late-onset schizophrenia and "Psychose Hallucinatoire Chronique", and the similarities between young-onset schizophrenia and chronic delusion syndromes. Clinical investigations clearly differentiate "Psychose Hallucinatoire Chronique" and late-onset-schizophrenia from young-onset schizophrenia because they have more delusion and hallucinatory symptoms, less negative symptoms, better evolution, and better sensitivity to antipsychotic drugs. Epidemiological data show that "Psychose Hallucinatoire Chronique" and late-onset schizophrenia have both a different sex-ratio (around 7 women for 1 man) than young-onset schizophrenia (nearly 1 woman for 1 man), and that in "Psychose Hallucinatoire Chronique" and in late-onset schizophrenia, social withdrawal is frequently observed before onset of the disorder. Lastly, putative risk factors may be shared by "Psychose Hallucinatoire Chronique" and late-onset schizophrenia, and may isolate them from young-onset schizophrenia, for example regarding the oestradiol hypothesis (oestradiol enhance dopamine efficacy and delay the onset of delusion disorders), the impact of sensory handicaps (which may be clinically and experimentally associated with hallucinations), or the role of genetic and familial factors (with a familial concentration intermediate between the familial concentration of schizophrenia of schizophrenic proband, and the familial concentration of schizophrenia of control probands). In accordance with this review of the literature, the authors conclude that the absence of specific criteria for late-onset schizophrenia and/or "Psychose Hallucinatoire Chronique" In

  16. [Antenatal corticosteroid therapy and late preterm infant morbidity and mortality].

    Science.gov (United States)

    Gázquez Serrano, I M; Arroyos Plana, A; Díaz Morales, O; Herráiz Perea, C; Holgueras Bragado, A

    2014-12-01

    Late preterm infants (34-36 weeks gestation) have a morbidity rate significantly higher than those born at term. However, few interventions have been undertaken to reduce this increased morbidity and mortality. Antenatal corticosteroid administration could be an effective preventive measure. The aim of this study was to describe the morbidity associated with late prematurity in our institution, and determine if there are differences between those who received antenatal corticosteroids. A prospective observational study was conducted on late preterm infants born in a tertiary hospital from October 2011 until September 2012. Two groups were formed according to whether or not they had received antenatal steroids. The rates of morbidity and mortality for each of the groups were analysed and compared. There was a total of 4127 live newborns during the study period, of whom 3795 were term and 332 were preterm (the overall prematurity rate was 8.04%). There were 247 late preterm deliveries, representing 6% of live born infants, and 74.4% of all premature infants. Of late preterm infants, 63.2% were admitted to the Neonatal Unit and 29.6% had received antenatal steroids. The incidence of admission to the Neonatal Unit and Neonatal Intensive Care, transient tachypnea, need for respiratory support in the form of continuous positive pressure airway and oxygen therapy, incidence of hypoglycemia, feeding difficulty, and jaundice requiring phototherapy were significantly higher (P<.05) in the late preterm group that did not receive antenatal steroids. Our finding suggests that the administration of antenatal corticosteroids to patients at risk of 34-36 weeks delivery could significantly reduce the cost and acute morbidity associated with late preterm birth. Copyright © 2013 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.

  17. Phenotypic cognitive impairment in late-onset delusional disorder.

    Science.gov (United States)

    Harris, Ben S; Kotsopoulos, Eleftheria J; Yamin, Sami

    2014-06-01

    Previous use of heterogeneous diagnostic criteria and insensitive cognitive measures has impeded clarification of the extent and type of cognitive impairment specific to late-onset delusional disorder. We examined whether clinical presentations of late-onset delusional disorder are associated with prodromal or established dementia, and whether it might be a discrete clinical syndrome characterized by its own profile of cognitive impairment. Nineteen patients with late-onset delusional disorder from a hospital psychiatric service and 20 patients with dementia of the Alzheimer's type (AD) from an outpatient memory clinic were recruited in a consecutive case series. All patients underwent comprehensive neuropsychological assessment that included general intellectual function, executive function, new learning and delayed memory, language, processing speed, and visuo-perceptual skills. Late-onset delusional disorder patients showed moderate impairment to conceptual reasoning, visual object recognition, processing speed, and confrontation naming. Severe impairment appeared in visuo-perceptual planning and organization, and divided attention. Compared with the Alzheimer's disease (AD) group, the late-onset delusional disorder group demonstrated significantly poorer visuo-perceptual skills but a significantly better capacity to consolidate information into delayed memory. A high rate of marked cognitive impairment occurs in late-onset delusional disorder. There was evidence of a conceptual reasoning deficit, plus the presence of a visuo-perceptual impairment affecting object recognition. This impairment profile can explain the genesis and maintenance of the observed delusions. Understanding late-onset delusional disorder as other than a purely psychiatric phenomenon or a precursor to AD will lead to better assessment and management approaches.

  18. Arctic Late Cretaceous and Paleocene Plant Community Succession

    Science.gov (United States)

    Herman, Alexei; Spicer, Robert; Daly, Robert; Jolley, David; Ahlberg, Anders; Moiseeva, Maria

    2010-05-01

    The Arctic abounds with Late Cretaceous and Paleocene plant fossils attesting to a thriving, diverse, but now extinct polar ecosystem that sequestered vast amounts of carbon. Through detailed examination of plant remains and their distributions in time and space with respect to their entombing sedimentary facies, it has been possible to reconstruct changes in Arctic vegetation composition and dynamics through the Late Cretaceous and into the Paleocene. Based on over 10,000 leaf remains, fossil wood and palynomorph assemblages from northeastern Russia and northern Alaska and palynological data from elsewhere in the Arctic we identify a number of successional plant communities (SPCs) representing seral development from early (pioneer), through middle to late SPCs and climax vegetation. We recognise that (1) Equisetites and some ferns (typically Birisia, but after the beginning of the Maastrichtian, Onoclea) were obligatory components of the early SPCs; (2) first rare angiosperms (e.g. the dicot Vitiphyllum multifidum) appeared in the middle SPCs of the Arctic in the Early - Middle Albian; (3) from late Albian times onwards angiosperms became abundant in the middle SPCs of the Arctic, but were still rare in the earlier and later SPCs; (4) monocots appeared in the Maastrichtian early SPCs; (5) all Arctic Cretaceous late SPCs (and climax vegetation) were dominated by conifers; (6) Arctic SPCs were more numerous and diverse under warm climates than cold; (7) during the Albian and late Cretaceous, advanced (Cenophytic, angiosperm-dominated) plant communities coexisted with those of a more relictual (Mesophytic, dominated by ferns and gymnosperms) aspect, and plants composing these communities did not mix; (8) coal-forming environments (mires) remained conifer, fern and bryophyte dominated throughout the late Cretaceous and Paleocene with little penetration of woody angiosperm components and thus are conservative and predominantly Mesophytic in character; (9) bryophytes

  19. Late Detection of Critical Congenital Heart Disease Among US Infants

    Science.gov (United States)

    Peterson, Cora; Ailes, Elizabeth; Riehle-Colarusso, Tiffany; Oster, Matthew E.; Olney, Richard S.; Cassell, Cynthia H.; Fixler, David E.; Carmichael, Suzan L.; Shaw, Gary M.; Gilboa, Suzanne M.

    2015-01-01

    IMPORTANCE Critical congenital heart disease (CCHD) was added to the Recommended Uniform Screening Panel for Newborns in the United States in 2011. Many states have recently adopted or are considering requirements for universal CCHD screening through pulse oximetry in birth hospitals. Limited previous research is directly applicable to the question of how many US infants with CCHD might be identified through screening. OBJECTIVES To estimate the proportion of US infants with late detection of CCHD (>3 days after birth) based on existing clinical practice and to investigate factors associated with late detection. DESIGN, SETTING, AND PARTICIPANTS Descriptive and multivariable analysis. Data were obtained from a multisite population-based study of birth defects in the United States, the National Birth Defects Prevention Study (NBDPS). We included all live-born infants with estimated dates of delivery from January 1, 1998, through December 31, 2007, and nonsyndromic, clinically verified CCHD conditions potentially detectable through screening via pulse oximetry. MAIN OUTCOMES AND MEASURES The main outcome measure was the proportion of infants with late detection of CCHD through echocardiography or at autopsy under the assumption that universal screening at birth hospitals might reduce the number of such late diagnoses. Secondary outcome measures included prevalence ratios for associations between selected demographic and clinical factors and late detection of CCHD. RESULTS Of 3746 live-born infants with nonsyndromic CCHD, late detection occurred in 1106 (29.5% [95%CI, 28.1%–31.0%]), including 6 (0.2%) (0.1% –0.4%) first receiving a diagnosis at autopsy more than 3 days after birth. Late detection varied by CCHD type from 9 of 120 infants (7.5%[95%CI, 3.5%–13.8%]) with pulmonary atresia to 497 of 801 (62.0% [58.7%–65.4%]) with coarctation of the aorta. In multivariable analysis, late detection varied significantly by CCHD type and study site, and infants with

  20. 2D CFT partition functions at late times

    Science.gov (United States)

    Dyer, Ethan; Gur-Ari, Guy

    2017-08-01

    We consider the late time behavior of the analytically continued partition function Z( β + it) Z( β - it) in holographic 2 d CFTs. This is a probe of information loss in such theories and in their holographic duals. We show that each Virasoro character decays in time, and so information is not restored at the level of individual characters. We identify a universal decaying contribution at late times, and conjecture that it describes the behavior of generic chaotic 2 d CFTs out to times that are exponentially large in the central charge. It was recently suggested that at sufficiently late times one expects a crossover to random matrix behavior. We estimate an upper bound on the crossover time, which suggests that the decay is followed by a parametrically long period of late time growth. Finally, we discuss gravitationally-motivated integrable theories and show how information is restored at late times by a series of characters. This hints at a possible bulk mechanism, where information is restored by an infinite sum over non-perturbative saddles.

  1. 2D CFT Partition Functions at Late Times

    CERN Document Server

    Dyer, Ethan

    2016-01-01

    We consider the late time behavior of the analytically continued partition function $Z(\\beta + it) Z(\\beta - it)$ in holographic $2d$ CFTs. This is a probe of information loss in such theories and in their holographic duals. We show that each Virasoro character decays in time, and so information is not restored at the level of individual characters. We identify a universal decaying contribution at late times, and conjecture that it describes the behavior of generic chaotic $2d$ CFTs out to times that are exponentially large in the central charge. It was recently suggested that at sufficiently late times one expects a crossover to random matrix behavior. We estimate an upper bound on the crossover time, which suggests that the decay is followed by a parametrically long period of late time growth. Finally, we discuss integrable theories and show how information is restored at late times by a series of characters. This hints at a possible bulk mechanism, where information is restored by an infinite sum over non-...

  2. Clinical characteristics of early- and late-onset gout

    Science.gov (United States)

    Zhang, Bingqing; Fang, Weigang; Zeng, Xuejun; Zhang, Yun; Ma, Ya; Sheng, Feng; Zhang, Xinlei

    2016-01-01

    Abstract A retrospective cross-sectional study using data from an outpatient clinic in China was conducted to investigate the clinical features of early-onset gout patients. All patients diagnosed with gout were asked about clinical characteristics of their gout and comorbid diseases. Patients presenting with acute flares were asked about common triggers before the flare. “Early-onset” gout was defined as onset of gout before 40 years and “late-onset” as onset ≥40 years. Major joint involvement, flare frequency before presentation, the cumulative number of involved joints, proportions of tophi complications at presentation, flare triggers, as well as any metabolic, cardiovascular, cerebrovascular, and renal comorbidities, were compared between the 2 groups. A total of 778 gout patients were enrolled in this study, including 449 (57.7%) in the early-onset group and 329 (42.3%) in the late-onset group. Compared with the late-onset gout patients, the early-onset gout patients had a higher proportion of ankle/mid-foot involvement (62.8% vs 48.2%, P gout patients had fewer metabolic, cardiovascular, cerebrovascular, or renal complications. Early- and late-onset gout patients had different clinical features. Early-onset seems to be influenced more by lifestyle, while late-onset patients have more complications because of comorbidities. PMID:27893683

  3. Late Jute seed production in cropland agroforestry system

    Directory of Open Access Journals (Sweden)

    Kazi Noor-E-Alam Jewel

    2015-12-01

    Full Text Available Farmers were not self-sufficient in jute seed production and cultivation to avoid use exotic jute seed from different resources. Though the conventional method of jute seed production was not enough to meet the demand of farmers because of shrinkage of jute seed production land. So, late jute seed production technique was applied in agroforestry systems at both established and newly developed orchards. The study was conducted in the selected three sites of Rangpur, Dinajpur and Faridpur. Both White (Corchorus capsularis L.cv. CVL-1 and Tossa (two popular cultivars, eg., Corchorus olitorius L. cv. O-9897, and cv. O-72 varieties were used for to evaluate the late jute seed production in cropland agroforestry in 2011- 2013. It was observed that 600 kg ha-1 to 725 kg ha-1 of jute seed was produced in different types of orchard plantation. Seeds from Litchi orchard showed the higher fiber yield (1051.11, 2511.11 and 3555.56 kg ha-1 at Rangpur, Dinajpur and Faridpur, respectively than the mango orchard. Nutrient contents of soil in three sits were improved significantly due to the cultivation of late jute seed production. Moreover, late jute seed production in early stages of orchard plantation was more profitable and late jute can be produced economically for five to seven years depending on the plantations type and age.

  4. Continental emergence in the Late Archean reconciles early and late continental growth models

    Science.gov (United States)

    Flament, Nicolas; Coltice, Nicolas; Rey, Patrice

    2014-05-01

    The analysis of ancient sediments (Rare Earth Element composition of black shales, isotopic strontium composition of marine carbonates, isotopic oxygen composition of zircons) suggests that continental growth culminated around the Archean-Proterozoic transition. In stark contrast, the geochemical analysis of ancient basalts suggests that depletion of the mantle occurred in the Hadean and Eoarchean. This paradox may be solved if continents were extracted from the mantle early in Earth's history, but remained mostly below sea level throughout the Archean. We present a model to estimate the area of emerged land and associated isotopic strontium composition of the mantle and oceans as a function of the coupled evolution of mantle temperature, continental growth and distribution of surface elevations (hypsometry). For constant continental hypsometry and four distinct continental growth models, we show that sea level was between 500 and 2000 m higher in the Archean than at present, resulting in isotopic composition of the mantle and oceans, we show that a reduced area of emerged continental crust can explain why the geochemical fingerprint of continents extracted early in Earth's history was not recorded at the surface of the Earth until the late Archean.

  5. Was Lates late? A null model for the Nile perch boom in Lake Victoria.

    Directory of Open Access Journals (Sweden)

    Andrea S Downing

    Full Text Available Nile perch (Lates niloticus suddenly invaded Lake Victoria between 1979 and 1987, 25 years after its introduction in the Ugandan side of the lake. Nile perch then replaced the native fish diversity and irreversibly altered the ecosystem and its role to lakeshore societies: it is now a prised export product that supports millions of livelihoods. The delay in the Nile perch boom led to a hunt for triggers of the sudden boom and generated several hypotheses regarding its growth at low abundances--all hypotheses having important implications for the management of Nile perch stocks. We use logistic growth as a parsimonious null model to predict when the Nile perch invasion should have been expected, given its growth rate, initial stock size and introduction year. We find the first exponential growth phase can explain the timing of the perch boom at the scale of Lake Victoria, suggesting that complex mechanisms are not necessary to explain the Nile perch invasion or its timing. However, the boom started in Kenya before Uganda, indicating perhaps that Allee effects act at smaller scales than that of the whole Lake. The Nile perch invasion of other lakes indicates that habitat differences may also have an effect on invasion success. Our results suggest there is probably no single management strategy applicable to the whole lake that would lead to both efficient and sustainable exploitation of its resources.

  6. The Importance of Mid-to-Late-Life Body Mass Index Trajectories on Late-Life Gait Speed.

    Science.gov (United States)

    Windham, B Gwen; Griswold, Michael E; Wang, Wanmei; Kucharska-Newton, Anna; Demerath, Ellen W; Gabriel, Kelley Pettee; Pompeii, Lisa A; Butler, Kenneth; Wagenknecht, Lynne; Kritchevsky, Stephen; Mosley, Thomas H

    2017-08-01

    Prior studies suggest being overweight may be protective against poor functional outcomes in older adults. Body mass index (BMI, kg/m2) was measured over 25 years across five visits (1987-2011) among Atherosclerosis Risk in Communities Study participants (baseline Visit 1 n = 15,720, aged 45-64 years). Gait speed was measured at Visit 5 ("late-life", aged ≥65 years, n = 6,229). BMI trajectories were examined using clinical cutpoints and continuous mixed models to estimate effects of patterns of BMI change on gait speed, adjusting for demographics and comorbidities. Mid-life BMI (baseline visit; 55% women; 27% black) was associated with late-life gait speed 25 years later; gait speeds were 94.3, 89.6, and 82.1 cm/s for participants with baseline normal BMI (<25), overweight (25 ≤ BMI < 30), and obese (BMI ≥ 30) (p < .001). In longitudinal analyses, late-life gait speeds were 96.9, 88.8, and 81.3 cm/s for participants who maintained normal, overweight, and obese weight status, respectively, across 25 years (p < .01). Increasing BMI over 25 years was associated with poorer late-life gait speeds; a 1%/year BMI increase for a participant with a baseline BMI of 22.5 (final BMI 28.5) was associated with a 4.6-cm/s (95% confidence interval: -7.0, -1.8) slower late-life gait speed than a participant who maintained a baseline BMI of 22.5. Being overweight in older age was not protective of mobility function. Maintaining a normal BMI in mid- and late-life may help preserve late-life mobility.

  7. Parental Attachment and Eating Behaviors in Late Adolescent Females

    Directory of Open Access Journals (Sweden)

    Amber-Leigh Rush

    2012-12-01

    Full Text Available Females demonstrating unhealthy eating behaviors in early adolescence may continue to exhibit them in later years, yet there is little empirical research including late adolescents. Attachment theories suggest that adolescents with eating disorders demonstrate insecure attachments to parents. This non-experimental descriptive study in 249 late adolescent females examined the relationship between eating behaviors and parental attachment, and explored the relationship between selected demographic variables and parental attachment. Participants responded to an electronically collected survey of demographic variables, self-reported eating behaviors, and completed the Parent Attachment Questionnaire. Participants reporting healthy eating behaviors had higher scores on two of the three maternal scales, indicating a greater level of attachment. Significantly higher scores were found for two maternal and two paternal attachment scales for selected sociodemographic variables. Quantifying parental attachment in late adolescent females enhances understanding of eating disorders in this population and may help to identify issues important to address in therapy.

  8. Clinical interventions for late-life anxious depression.

    Science.gov (United States)

    Diefenbach, Gretchen J; Goethe, John

    2006-01-01

    Anxiety symptoms are frequently present in patients with late-life depression. The designation "anxious depression" has been used to describe major depressive disorder (MDD) accompanied by clinically significant but subsyndromal anxiety symptoms. MDD may also present comorbid with diagnosable anxiety disorders, although this presentation is less common in late life. Diagnosis of anxious depression in the elderly is complicated by several factors (eg, their tendency to experience and report psychiatric symptoms as somatic illness) and is associated with a more severe clinical presentation, increased risk for suicidal ideation, increased disability, and poorer prognosis. Standard pharmacotherapy for depression may be sufficient but for many patients must be modified or augmented. Psychosocial interventions may also be an important component in the treatment of these patients, although no specific psychosocial treatments have been developed for late-life anxious depression.

  9. Influence of social factors on patient-reported late symptoms

    DEFF Research Database (Denmark)

    Kjaer, Trille Kristina; Johansen, Christoffer; Andersen, Elo;

    2016-01-01

    BACKGROUND: The incidence of head and neck cancer and morbidity and mortality after treatment are associated with social factors. Whether social factors also play a role in the prevalence of late-onset symptoms after treatment for head and neck cancer is not clear. METHODS: Three hundred sixty...... ratio [OR] = 3.20; 95% confidence interval [CI] = 1.18-8.63). For survivors who lived alone, the adjusted ORs were significantly increased for physical functioning (2.17; 95% CI = 1.01-4.68) and trouble with social eating (OR = 2.26; 95% CI = 1.14-4.47). CONCLUSION: Self-reported severe late symptoms...... were more prevalent in survivors with short education and in those living alone, suggesting differences in perception of late symptoms between social groups. © 2015 Wiley Periodicals, Inc. Head Neck, 2015....

  10. Tectonic model for the Late Paleozoic of southeastern New England

    Energy Technology Data Exchange (ETDEWEB)

    Wintsch, R.P.; Sutter, J.F.

    1986-07-01

    Hornblende and biotite /sup 40/Ar//sup 39/Ar age spectra from rocks in south-central Connecticut help define a Permian-Triassic cooling curve for the area. Together with petrologic and structural information, a time-temperature-pressure-strain path is established. Similar data for the Narragansett basin in Rhode Island and Massachusetts allow correlation of the late Paleozoic histories of the two areas. Together, these data suggest that in the late Paleozoic, south-central New England was part of a fold-thrust belt, and the Narragansett basin was a retroarc foreland basin. NW-SE compression during the final assembly of Pangaea resulted in SE directed thrusting, causing the development of clastic wedges in adjacent Rhode Island and Massachusetts in the Late Carboniferous-Early Permian. A clockwise rotation of this deformation from NW to NNE led to northward underthrusting and concomitant uplift of both eastern Connecticut and Rhode Island in the Permian and Triassic.

  11. Intracranial hemorrhage in late hemorrhagic disease of the newborn.

    Science.gov (United States)

    Pooni, Puneet A; Singh, Daljit; Singh, Harmesh; Jain, B K

    2003-03-01

    This study was conducted to evaluate the clinical profile and outcome in late hemorrhagic disease of the newborn (HDN) with particular reference to intracranial hemorrhage. Infants (n = 42) presenting with late HDN from January 1998 to December 2001 were studied. Majority (76%) were in the age group of 1-3 months. All were term babies on exclusive breast-feeding and none received vitamin K at birth. 71% patients presented with intracranial hemorrhage, commonest site being intracerebral and multiple ICH. Visible external bleeding was noted in 1/3rd of patients only. Three patients expired. Late HDN is still an important cause of mortality and morbidity in developing countries where vitamin K prophylaxis is not routinely practiced. Isolated intracranial hemorrhage is a common mode of presentation.

  12. Screening for late-onset Pompe disease in Finland.

    Science.gov (United States)

    Palmio, Johanna; Auranen, Mari; Kiuru-Enari, Sari; Löfberg, Mervi; Bodamer, Olaf; Udd, Bjarne

    2014-11-01

    Pompe disease (glycogen storage disease type II) is caused by autosomal recessive mutations in GAA gene. The estimated frequency of late-onset Pompe disease is around 1:60,000. However, only two infantile and one late-onset Pompe patients have been reported in Finland with a population of 5 million. We screened for late-onset Pompe disease in a cohort of undetermined myopathy patients with proximal muscle weakness and/or elevated serum creatine kinase values. Acid α-glucosidase (GAA) activity in dried blood spots was measured and clinical data collected in 108 patients. Four patients had low normal GAA activity; all the others had activities well within the normal range. Re-analyses of these patients did not reveal new Pompe patients. Our findings suggest that Pompe disease is extremely rare in Finland. Finland is an example of an isolated population with enrichment of certain mutations for genetic disorders and low occurrence of some autosomal recessive diseases.

  13. Internal dosimetry of plutonium using the late urinary excretion.

    Science.gov (United States)

    Sharma, R C; Abani, M C

    2000-10-01

    An attempt has been made to standardize the methodology of internal dose computation from the late urinary excretion data. The methodology was selected keeping in mind the most recent ICRP publications and the results of internal dosimetry intercomparison studies reported in literature. The key element of this methodology is the PC-based computational software LUDEP 2.05, which implements the new model of the human respiratory tract. Late urinary excretion data of three male subjects involved in accidental intakes of plutonium aerosols more than 25 years ago were interpreted in terms of intakes and internal doses with the aid of the standardized methodology. An important implication of this work is that late urinary excretion data of the occupational workers of any plutonium handling facility could be used to show the compliance with the life-time dose limit.

  14. Late preterms: A vulnerable group needing due attention

    Directory of Open Access Journals (Sweden)

    Milind M Jambagi

    2012-01-01

    Full Text Available "Late preterms may be apparently normal but a vulnerable group of preterm infants needing due attention both by the Obstetricians and Pediatricians. Late preterms like any other preterms are vulnerable to complications such as Respiratory Distress Syndrome (RDS and other complications seen in a preterm infant. The American Congress of Obstetricians and Gynecologists guidelines recommend administration of antenatal corticosteroids in a mother in premature labor only up to the gestational age of 34 weeks. This is a case report of a preterm baby with a gestational age of 35 weeks which presented with RDS. We are hereby reporting this case to draw attention of the Obstetricians and Pediatricians toward this entity of ′Late Preterm′ to provide better care to them and obtain better outcomes."

  15. Late Holocene eolian fossilization of Podzols in Northeastern Germany

    Science.gov (United States)

    Hirsch, Florian; Raab, Thomas; Schneider, Anna; Wechler, Klaus-Peter

    2016-04-01

    The North European lowland has been formed by glacial and periglacial processes in the Late Pleistocene. Multiple reshaping since the Late Glacial considerably changed the landscape up to and including especially historic times. Sediment sequences and (fossilized) soils can improve our understanding of Late Quaternary landscape development, but mapping of buried soils and surfaces is often limited to single outcrops. Ongoing archaeological rescue excavations in the pre-field of the open-cast mine Cottbus-Nord (northeastern Germany) with dense excavation trenches in an about 10 ha dune and drift sand area reveal multilayered sediment sequences with fossilized soils and sediments from the Late Pleistocene to the Late Holocene. Archaeological findings ranging from Mesolithic flint stones to an about 200 year old ceramics in eolian sediments covering plow horizons and wheel tracks suggest that eolian relocation of sandy material was intensive about 200 years ago. Still unpublished OSL dating underline the intense eolian activity. Recent studies showed that between the 15Th to the 19Th century an iron smelter 5 km to the west of our study site was supplied with charcoal, which was produced in a forest 5 km east to our study site. Our current findings about Late Holocene eolian activity raise the question if this eolian reshaping of the landscape is connected with the operation of the iron smelter either directly by transport or bog iron ore winning or indirectly by population pressure caused by the prospering iron smelter. Our ongoing research indicates, that already for historic land-use off-site effects causing further landscape changes have to be considered.

  16. Better late than never: information retrieval from black holes.

    Science.gov (United States)

    Braunstein, Samuel L; Pirandola, Stefano; Życzkowski, Karol

    2013-03-08

    We show that, in order to preserve the equivalence principle until late times in unitarily evaporating black holes, the thermodynamic entropy of a black hole must be primarily entropy of entanglement across the event horizon. For such black holes, we show that the information entering a black hole becomes encoded in correlations within a tripartite quantum state, the quantum analogue of a one-time pad, and is only decoded into the outgoing radiation very late in the evaporation. This behavior generically describes the unitary evaporation of highly entangled black holes and requires no specially designed evolution. Our work suggests the existence of a matter-field sum rule for any fundamental theory.

  17. Paraphrenia: paranoid states of late life. I. European research.

    Science.gov (United States)

    Bridge, T P; Wyatt, R J

    1980-05-01

    American psychiatry has traditionally viewed late-life paranoid states either as rare or not part of the schizophrenic syndrome. European psychiatry has not subscribed to this view. The literature (chiefly European) is reviewed from the standpoints of history of the disorder, diagnostic reliability, pre-onset sensory loss, the multiple determinants of paranoia, and the response of paraphrenic patients to treatment with phenothiazines. The evidence leads to the conclusion that late-life paranoid states are not rare, and that the diagnosis "paraphrenia" has real clinical utility. Moreover, there seems to be a substantial relationship between schizophrenia and paraphrenia.

  18. [Prevalence of early and late dumping after gastric bypass].

    Science.gov (United States)

    Héraïef, R; Giusti, V

    2014-03-26

    Gastric bypass surgery is an effective treatment of obesity, bringing a significant weight loss and a major improvement of carbohydrate profile. However, in some patients, a deregulation in carbohydrate metabolism between insulin secretion and sensitivity is observed, whereupon early and late dumping happen. Their prevalence isn't well studied, although it seems that 10 to 20% of patients are affected. We've studied a cohort of 70 patients who undergone gastric bypass surgery at the CHUV. 18 (25.7%) patients have a positive anamnesis for early dumping and 10 (14.3%) for late dumping, being it superior as what is described in the literature.

  19. Emerging concepts for myocardial late gadolinium enhancement MRI.

    Science.gov (United States)

    Doltra, Adelina; Amundsen, Brage Hoyem; Gebker, Rolf; Fleck, Eckart; Kelle, Sebastian

    2013-08-01

    Late gadolinium enhancement is a useful tool for scar detection, based on differences in the volume of distribution of gadolinium, an extracellular agent. The presence of fibrosis in the myocardium amenable to be detected with late gadolinium enhancement MRI is found not only in ischemic cardiomyopathy, in which it offers information regarding viability and prognosis, but also in a wide variety of non-ischemic cardiomyopathies. In the following review we will discuss the methodological aspects of gadolinium-based imaging, as well as its applications and anticipated future developments.

  20. Diagnosis and management of late hepatic allograft dysfunction

    Institute of Scientific and Technical Information of China (English)

    MEI Jian-min; YU Cong-hui

    2005-01-01

    Late hepatic allograft dysfunction (LHAD) is common after liver transplantation (LT) and can cause graft failure,retransplantation,or even death.A variety of etiologies including rejection,vascular complications,bile duct complications,recurrent diseases,infections,de novo diseases,neoplasms and drug toxicity can result in LHAD.The recurrent diseases have the potential to become the most serious problems facing LT in the future.It is difficult to differentiate late acute rejection from recurrent viral or autoimmune hepatitis.Accurate diagnosis of the cause of LHAD has therapeutic importance.

  1. Trachyteuthis covacevichi n. sp., a Late Jurassic Palaeopacific coleoid cephalopod

    Directory of Open Access Journals (Sweden)

    D. Fuchs

    2008-02-01

    Full Text Available A new early Oxfordian coleoid cephalopod, Trachyteuthis covacevichi n. sp., is described from northern Chile. It represents the first Late Jurassic Palaeopacific vampyropod and thus considerably extends the palaeogeographic distribution of trachyteuthids. In general, Tr. covacevichi n. sp. possesses a gladius typical for the genus, but wider than in other species. Similarities between Tr. covacevichi n. sp., Tr. palmeri from the Oxfordian of Cuba and Tr. sp. from the Kimmeridgian of Europe confirm a Caribbean Seaway between the Tethys and the Palaeopacific during Late Jurassic times. Morphologically, the wide gladius of Tr. covacevichi n. sp. supports a close phylogenetic relationship between Teudopsis and Trachyteuthis. doi:10.1002/mmng.200700012

  2. Association of Microvascular Dysfunction With Late-Life Depression

    DEFF Research Database (Denmark)

    van Agtmaal, Marnix J M; Houben, Alfons J H M; Pouwer, Frans

    2017-01-01

    Importance: The etiologic factors of late-life depression are still poorly understood. Recent evidence suggests that microvascular dysfunction is associated with depression, which may have implications for prevention and treatment. However, this association has not been systematically reviewed...... microvascular dysfunction might provide a potential target for the prevention and treatment of depression........ Objective: To examine the associations of peripheral and cerebral microvascular dysfunction with late-life depression. Data Sources: A systematic literature search was conducted in MEDLINE and EMBASE for and longitudinal studies published since inception to October 16, 2016, that assessed the associations...

  3. Opportunistic Ports and Spaces of Exchange in Late Roman Cyprus

    Science.gov (United States)

    Leidwanger, Justin

    2013-12-01

    Ports served not only as interfaces between land and sea, but as central gathering spaces for economic and cultural exchange. Drawing on case studies from the eastern Mediterranean island of Cyprus, this paper situates opportunistic ports lacking built facilities within a broader socioeconomic context of diverse maritime communications, expanding rural settlement, and increased agricultural productivity during late antiquity. Though simple, these sites served as active agents in the development of new maritime networks as well as local markets throughout their hinterlands, adding flexibility and dynamism to the economic ties between city, countryside, and the wider late Roman world.

  4. CHINA NATIONAL POLICY IN THE LATE 1950'S TO THE LATE 1970'S

    Directory of Open Access Journals (Sweden)

    D. V. Buyarov

    2016-01-01

    Full Text Available This article discusses the key features of the national policy of the Chinese government in respect of nonHan peoples. The relevance of this work is due to important national issue for China. Traditionally, China has evolved as a multinational state, which was caused solely as a factor of external influence, for example, the Mongol and Manchu invasion and implementation of foreign policy objectives aimed at expanding the boundaries, resulting in a connection of Xinjiang and Tibet. A key feature of China as a multiethnic state has always been a numerical predominance of one ethnic group - the Han, as a rule, makes up almost all periods of the history of China, about 90% of the population. At the same time, China has always been inhabited by many ethnic minorities, which are not only occasionally something borrowed from Han people, but also constantly subjected Sinification. Sinification it was and remains one of the leading destinations for small nations. With the formation of the PRC in 1949, before the new communist government faced the problem of alignment of the national policy with regard to national minorities. The national policy of the Communist Party of China in its development has passed through three stages. In this article is considered the second period of this policy since the late 1950‟s. When starting to implement policies "Great Leap Forward" and the end of 1970‟s., as a result of the reforms of Deng Xiaoping began to change and the situation of small nations. To date, the Chinese government's policy towards national minorities in general, aims to accelerate the socio-economic and cultural development of ethnic groups on the tightening of national areas to the level of the developed regions of China, which should consolidate the Chinese citizens and prevent separatist actions. Ethnic identity of small nations overshadowed and leveled.

  5. Functional interchangeability of late domains, late domain cofactors and ubiquitin in viral budding.

    Directory of Open Access Journals (Sweden)

    Maria Zhadina

    Full Text Available The membrane scission event that separates nascent enveloped virions from host cell membranes often requires the ESCRT pathway, which can be engaged through the action of peptide motifs, termed late (L- domains, in viral proteins. Viral PTAP and YPDL-like L-domains bind directly to the ESCRT-I and ALIX components of the ESCRT pathway, while PPxY motifs bind Nedd4-like, HECT-domain containing, ubiquitin ligases (e.g. WWP1. It has been unclear precisely how ubiquitin ligase recruitment ultimately leads to particle release. Here, using a lysine-free viral Gag protein derived from the prototypic foamy virus (PFV, where attachment of ubiquitin to Gag can be controlled, we show that several different HECT domains can replace the WWP1 HECT domain in chimeric ubiquitin ligases and drive budding. Moreover, artificial recruitment of isolated HECT domains to Gag is sufficient to stimulate budding. Conversely, the HECT domain becomes dispensable if the other domains of WWP1 are directly fused to an ESCRT-1 protein. In each case where budding is driven by a HECT domain, its catalytic activity is essential, but Gag ubiquitination is dispensable, suggesting that ubiquitin ligation to trans-acting proteins drives budding. Paradoxically, however, we also demonstrate that direct fusion of a ubiquitin moiety to the C-terminus of PFV Gag can also promote budding, suggesting that ubiquitination of Gag can substitute for ubiquitination of trans-acting proteins. Depletion of Tsg101 and ALIX inhibits budding that is dependent on ubiquitin that is fused to Gag, or ligated to trans-acting proteins through the action of a PPxY motif. These studies underscore the flexibility in the ways that the ESCRT pathway can be engaged, and suggest a model in which the identity of the protein to which ubiquitin is attached is not critical for subsequent recruitment of ubiquitin-binding components of the ESCRT pathway and viral budding to proceed.

  6. The Solanum demissumR8 late blight resistance gene is an Sw-5 homologue that has been deployed worldwide in late blight resistant varieties

    NARCIS (Netherlands)

    Vossen, Jack H.; Arkel, van Gert; Bergervoet-van Deelen, Marjan; Jo, Kwang Ryong; Jacobsen, Evert; Visser, Richard G.F.

    2016-01-01

    The potato late blight resistance geneR8has been cloned.R8is found in five late blight resistant varieties deployed in three different continents. R8 recognises Avr8 and is homologous to the NB-LRR protein Sw-5 from tomato.Abstract: The broad spectrum late blight resistance gene R8 from Solanum

  7. LATE DEVONIAN CONODONTS FROM THE HOJEDK SECTION, KERMAN PROVINCE, SOUTHEASTERN IRAN

    Directory of Open Access Journals (Sweden)

    HOSSEIN GHOLAMALIAN

    2008-07-01

    Full Text Available Conodonts (34 species and subspecies from the Hojedk section north of Kerman span the late Givetian to early Famennian. The new data suggest that Devonian biostromes in central and eastern Iran were deposited on differing levels, and that the currently accepted ranges of Icriodus excavatus, Polygnathus subincompletus and P. mosquensis are late Givetian - late Frasnian, early to late Frasnian, and middle to late Frasnian. Polygnathus ashourii n. sp. is proposed. 

  8. Late osteoarticular lesions following meningococcemia with disseminated intravascular coagulation

    Energy Technology Data Exchange (ETDEWEB)

    Santos, E.; Boavida, J.E.; Barroso, A.; Carmona da Mota, H.; Seabra, J.

    1989-03-01

    Nineteen children, who had been admitted to the Pediatric Hospital of Coimbra with severe meningococcal infection with DIC, were submitted to clinical and radiological examination, an average of 4.2 years after hospitalization, in order to demonstrate late skeletal lesions. Patellar dystrophy, to our knowledge previously unreported, was found in 4 children, all of whom had overlying cutaneous scarring.

  9. Occupational cognitive requirements and late-life cognitive aging

    NARCIS (Netherlands)

    Pool, Lindsay R.; Weuve, Jennifer; Wilson, Robert S.; Bultmann, Ute; Evans, Denis A.; de Leon, Carlos F. Mendes

    2016-01-01

    Objective:To examine whether occupational cognitive requirements, as a marker of adulthood cognitive activity, are associated with late-life cognition and cognitive decline.Methods:Main lifetime occupation information for 7,637 participants aged >65 years of the Chicago Health and Aging Project

  10. Prospects for advanced late blight resistance breeding in potato

    Science.gov (United States)

    The potato late blight pathogen, Phytophthora infestans, is able to rapidly evolve to overcome resistance genes. The pathogen accomplishes this by secreting an arsenal of proteins, termed effectors, that function to modify host cells. Although hundreds of candidate effectors have been identified in ...

  11. Session Introduction: Global correlation on late Quaternary paleovalley systems

    NARCIS (Netherlands)

    Cohen, K.M.; Amorosi, A.; Busschers, F.S.; Hori, K.; Tanabe, S.

    2015-01-01

    All around the world, paleovalley systems have trapped great amounts of deposits and hold a quite complete Late Quaternary record. Uniquely, these records directly interlink the shelf marine with the hinterland fluvial realms. In the vicinity of ice sheets, in similar ways, paleovalleys interlink th

  12. Parental Attachment and Identity in Portuguese Late Adolescents.

    Science.gov (United States)

    Matos, Paula Mena; Barbosa, Sonia; de Almeida, Helena Milheiro; Costa, Maria Emilia

    1999-01-01

    Based on life span attachment perspective and on identity status paradigm, this study investigated the relationship between attachment and identity in a sample of 361 Portuguese late adolescents as a function of parental and adolescent gender. The results indicated gender differences in the association between attachment variables and identity…

  13. The impact of late budgets on state government borrowing costs

    DEFF Research Database (Denmark)

    Andersen, Asger Lau; Lassen, David Dreyer; Nielsen, Lasse Holbøll Westh

    2014-01-01

    a cumulative impact that is equivalent to a one-time increase in the yield spread of around 10 basis points. States with sufficient liquidity incur no costs from late budgets, while unified governments face large penalties from not finishing a budget on time. © 2013 Elsevier B.V....

  14. Identity Development in the Late Twenties: A Never Ending Story

    Science.gov (United States)

    Carlsson, Johanna; Wängqvist, Maria; Frisén, Ann

    2015-01-01

    The aim of this study was to investigate identity development in the late 20s in order to learn more about the continued identity development after identity commitments have been made. The starting point for the study was the contradiction between ideas of identity development as a lifelong process and identity status research showing that…

  15. Telomere length is longer in women with late maternal age

    DEFF Research Database (Denmark)

    Fagan, Erin; Sun, Fangui; Bae, Harold

    2017-01-01

    OBJECTIVE:: Maternal age at birth of last child has been associated with maternal longevity. The aim of this study was to determine whether older women with a history of late maternal age at last childbirth had a longer leukocyte telomere length than those with maternal age at last childbirth of ...

  16. Late degeneration in rabbit tissues after irradiation by heavy ions

    Science.gov (United States)

    Lett, J. T.; Cox, A. B.; Keng, P. C.; Lee, A. C.; Su, C. M.; Bergtold, D. S.

    1980-01-01

    Results are presented for investigations of the late effects of heavy-ion irradiation on rabbit tissues which were undertaken to assess the hazards associated with the long-term exposure of humans to heavy ions in space during such activities as the construction of solar power stations or voyages to Mars. White rabbits approximately six weeks old were exposed to various doses of collimated beams of 400-MeV/n Ne ions, 570 MeV/n Ar ions and Co-60 gamma rays directed through both eyes, and the responses of the various tissues (hair follicles, skin, cornea, lens, retina, Harderian glands, bone and forebrain) were examined. Proliferating tissues are found to exhibit high damage levels in the early and late periods following irradiation, while terminally differentiating tissues repond to radiation most intensely in the late period, years after irradiation, with no intermediate recovery. The results obtained from rabbits are used to predict the occurrence of late tissue degeneration in the central nervous system, terminally differentiating systems and stem cells of humans one or more decades following exposure to radiation levels anticipated during long-duration space flights. The studies also indicate that tissues may be prematurely aged in the sense that tissue life spans may be shortened without the development of malignancies.

  17. Collaboration between Content and Language Specialists in Late Immersion

    Science.gov (United States)

    Kong, Stella

    2014-01-01

    This paper reports a qualitative case study of a collaborative project between an ESL researcher and a history teacher teaching in a late immersion school in Hong Kong. The project aims to help a Grade 9 class to write history essays on their own instead of copying from the textbook, which is a common phenomenon in Hong Kong schools. The…

  18. Late-onset CMV disease following CMV prophylaxis.

    LENUS (Irish Health Repository)

    Donnelly, C

    2012-02-01

    BACKGROUND: Cytomegalovirus (CMV) is the most common opportunistic infection after solid-organ transplantation, increasing morbidity and mortality. Three months of oral valganciclovir have been shown to provide effective prophylaxis. Late-onset CMV disease, occurring after the discontinuation of prophylaxis, is now increasingly recognised. AIMS: To investigate the incidence and the time of detection of CMV infections in liver transplant recipients who received CMV prophylaxis. METHODS: Retrospective review of 64 high- and moderate-risk patients with 1 year of follow-up. RESULTS: The incidence of CMV infection was 12.5%, with 4.7% disease. All cases of symptomatic CMV disease were of late-onset. CONCLUSIONS: The incidence of CMV infections in this study was low compared with literature reports; however, the late-onset disease is an emerging problem. Detection of late-onset disease may be delayed because of less frequent clinic follow-up visits. Increased regular laboratory monitoring may allow earlier detection at the asymptomatic infection stage.

  19. [Language Delay: What is the Prognosis of Late Bloomers?].

    Science.gov (United States)

    Kühn, P; Sachse, S; von Suchodoletz, W

    2015-07-01

    30-50% of late talkers catch-up their language delay during the third year of life. So far it is unclear whether this is a permanent or an illusionary recovery. The aim of the study was to examine the further language development of late bloomers. Language skills of 83 three-year-old children (16 late bloomers [LB], 29 late talkers [LT] with persistent language problems, 38 Non-LT) were assessed with a standardized language test. Before school entry formal language skills, expressive and receptive vocabulary and precursors of written language (verbal memory, phonological awareness, verbal information-processing speed) were assessed. At follow-up before school entry LB scored below Non-LT on phonological memory test. 31% of the LB in contrast to 3% of the Non-LT had slight language problems. 38% had received speech-language therapy. Nevertheless, no LB met the criteria of developmental language disorder. The language skills of LT with persistent language problems remained significantly below the level of LB and Non-LT. Every fourth of these children was language impaired. LB as a group are not at risk for later clinically relevant language disorders. However, their language abilities are often within the lower range of normal variation. Therefore, it is recommended to facilitate their language acquisition either by kindergarten training programs or by parent-directed intervention programs to provide a more stimulating environment. © Georg Thieme Verlag KG Stuttgart · New York.

  20. Early Embedding and Late Reranking for Video Captioning

    NARCIS (Netherlands)

    Dong, J.; Li, X.; Lan, W.; Huo, Y.; Snoek, C.G.M.

    2016-01-01

    This paper describes our solution for the MSR Video to Language Challenge. We start from the popular ConvNet + LSTM model, which we extend with two novel modules. One is early embedding, which enriches the current low-level input to LSTM by tag embeddings. The other is late reranking, for re-scoring

  1. Development of Emotional Facial Recognition in Late Childhood and Adolescence

    Science.gov (United States)

    Thomas, Laura A.; De Bellis, Michael D.; Graham, Reiko; Labar, Kevin S.

    2007-01-01

    The ability to interpret emotions in facial expressions is crucial for social functioning across the lifespan. Facial expression recognition develops rapidly during infancy and improves with age during the preschool years. However, the developmental trajectory from late childhood to adulthood is less clear. We tested older children, adolescents…

  2. Overcoming obstacles to late presentation for HIV infection in Europe

    DEFF Research Database (Denmark)

    Lazarus, Jeff; Jürgens, R; Weait, M;

    2011-01-01

    The central goal of the HIV in Europe Initiative is to promote testing and treatment throughout Europe and Central Asia in order to decrease the number of people living with HIV presenting late for care. This article summarizes the results from the HIV in Europe 2009 Conference and the early resu...

  3. LATE DEVONIAN-CARBONIFEROUS CONODONTS FROM EASTERN IRAN

    Directory of Open Access Journals (Sweden)

    MEHDI YAZDI

    1999-07-01

    Full Text Available Conodont data from acid-leaching 110 samples from two Late Devonian-Carboniferous areas in the Shotori Range (Tabas region of eastern Iran are presented. At Howz-e-Dorah, a section (88 samples commencing high in the Bahram Formation (Givetian-early Frasnian extended through the Shishtu Formation (Frasnian, Early hassi Zone or older, to latest Tournaisian, anchoralis-latus Zone and the Sardar Formation (earliest Visean, texanus Zone, to late Namurian, sinuatus-corrugatus-sulcatus Zone and into the Jamal Formation (Permian. Four less exhaustively sampled sections (22 samples show the Kale Sardar area to be tectonically more complicated than the Howz-e-Dorah area. Useful marker horizons in the Howz-e-Dorah section, well constrained by conodont data, are: the early Frasnian (no older than Early hassi Zone biostromal beds of the Shishtu Formation, an early Famennian (Late triangularis to Early crepida interval of oolitic limestone, a cyclothem sequence straddling the Early Carboniferous-Late Carboniferous boundary, and an Early Permian interval of siliceous sand ("the white quartzite" of previous authors. Additionally, several iron-rich horizons, readily traceable from locality to locality, are well constrained by conodont ages. Eighty-five conodont species/subspecies are documented representing 24 genera.. Two new species, Polygnathus capollocki and Polygnathus ratebi and one new subspecies, Icriodus alternatus mawsonae are described. 

  4. Energiemarkten en energiehandel in Holland in de late middeleeuwen

    NARCIS (Netherlands)

    Cornelisse, Charles Louis Eduard

    2007-01-01

    This study analyses the economical and commercial development of Holland in the late Middle Ages, focusing on the fuel market and fuel trade. Energy was of vital importance to this society in which industry, trade and export were expanding rapidly. The brisk commercial and industrial development of

  5. Late Miocene Sciuridae (Mammalia, Rodentia) from Anatolia, Turkey

    NARCIS (Netherlands)

    Bosma, A.A.; de Bruijn, H.; Wessels, W.

    2013-01-01

    Isolated cheek teeth of Sciuridae (Rodentia, Mammalia) from nine late Miocene localities in central Anatolia (Turkey) are described. The teeth represent at least 12 different species, five of which belong to the ground squirrel genus Tamias, two to the ground squirrel genus Spermophilinus, one to th

  6. Stress, Self-Esteem, and Suicidal Ideation in Late Adolescents

    Science.gov (United States)

    Wilburn, Victor R.; Smith, Delores E.

    2005-01-01

    The relationships among stress, self-esteem, and suicidal ideation in late adolescents were examined in a group of college students. Multiple regression analysis indicated that both stress and self-esteem were significantly related to suicidal ideation; low self-esteem and stressful life events significantly predicted suicidal ideation. The…

  7. Late-Onset Startle Syndrome and Obsessive Compulsive Disorder

    Directory of Open Access Journals (Sweden)

    Alejandro Gonzalez

    1998-01-01

    Full Text Available A case of late onset sporadic startle syndrome in a patient with a right posterior fossa brain tumour is reported. The exaggerated startle response did not respond to treatment with clonazepam. In addition to anxiety and depression, the patient developed obsessive- compulsive symptoms which responded to behavioural therapy. The possible mechanisms for this unique pattern of symptoms are discussed.

  8. Late Pleistocene adult mortality patterns and modern human establishment.

    Science.gov (United States)

    Trinkaus, Erik

    2011-01-25

    The establishment of modern humans in the Late Pleistocene, subsequent to their emergence in eastern Africa, is likely to have involved substantial population increases, during their initial dispersal across southern Asia and their subsequent expansions throughout Africa and into more northern Eurasia. An assessment of younger (20-40 y) versus older (>40 y) adult mortality distributions for late archaic humans (principally Neandertals) and two samples of early modern humans (Middle Paleolithic and earlier Upper Paleolithic) provides little difference across the samples. All three Late Pleistocene samples have a dearth of older individuals compared with Holocene ethnographic/historical samples. They also lack older adults compared with Holocene paleodemographic profiles that have been critiqued for having too few older individuals for subsistence, social, and demographic viability. Although biased, probably through a combination of preservation, age assessment, and especially Pleistocene mobility requirements, these adult mortality distributions suggest low life expectancy and demographic instability across these Late Pleistocene human groups. They indicate only subtle and paleontologically invisible changes in human paleodemographics with the establishment of modern humans; they provide no support for a life history advantage among early modern humans.

  9. Close Relationships and Attributions for Peer Victimization among Late Adolescents

    Science.gov (United States)

    Chen, Xiaochen; Graham, Sandra

    2012-01-01

    This study examined the effect of close relationships (best friendship and romantic relationship) on late adolescents' casual attributions for peer victimization. A total of 1106 twelfth grade students completed self-report measures of perceived peer victimization, self-blame attribution, psychological maladjustment (loneliness and social…

  10. Maternal and fetal factors observed with late preterm births

    Directory of Open Access Journals (Sweden)

    Madhusudan Dey

    2015-08-01

    Conclusion: Higher incidences of hypertensive disorders of pregnancy, anaemia and preterm premature rupture of membrane were found with late preterm birth and 10% of newborns required NICU care. [Int J Res Med Sci 2015; 3(8.000: 1969-1973

  11. Late-onset myasthenia not on the increase

    DEFF Research Database (Denmark)

    Pedersen, E G; Hallas, Jesper; Hansen, K

    2013-01-01

    BACKGROUND: An increase in late-onset myasthenia gravis (MG) has been reported. There are few large population-based studies over longer periods of time reflecting recent developments in MG incidence. METHODS: We identified a nationwide cohort of patients with incident myasthenia in Denmark in 1996...

  12. Development of Emotional Facial Recognition in Late Childhood and Adolescence

    Science.gov (United States)

    Thomas, Laura A.; De Bellis, Michael D.; Graham, Reiko; Labar, Kevin S.

    2007-01-01

    The ability to interpret emotions in facial expressions is crucial for social functioning across the lifespan. Facial expression recognition develops rapidly during infancy and improves with age during the preschool years. However, the developmental trajectory from late childhood to adulthood is less clear. We tested older children, adolescents…

  13. Antarctic and Southern Ocean influences on Late Pliocene global cooling

    NARCIS (Netherlands)

    McKay, R.; Naish, T.; Carter, L.; Riesselman, C.; Dunbar, R.; Sjunneskog, C.; Winter, D.; Sangiorgi, F.; Warren, C.; Pagani, M.; Schouten, S.; Willmott, V.; Levy, R.; DeConto , R.M.; Powell, R.D.

    2012-01-01

    The influence of Antarctica and the Southern Ocean on Late Pliocene global climate reconstructions has remained ambiguous due to a lack of well-dated Antarctic-proximal, paleoenvironmental records. Here we present ice sheet, sea-surface temperature, and sea ice reconstructions from the ANDRILL

  14. Transport to late endosomes is required for efficient reovirus infection.

    Science.gov (United States)

    Mainou, Bernardo A; Dermody, Terence S

    2012-08-01

    Rab GTPases play an essential role in vesicular transport by coordinating the movement of various types of cargo from one cellular compartment to another. Individual Rab GTPases are distributed to specific organelles and thus serve as markers for discrete types of endocytic vesicles. Mammalian reovirus binds to cell surface glycans and junctional adhesion molecule-A (JAM-A) and enters cells by receptor-mediated endocytosis in a process dependent on β1 integrin. Within organelles of the endocytic compartment, reovirus undergoes stepwise disassembly catalyzed by cathepsin proteases, which allows the disassembly intermediate to penetrate endosomal membranes and release the transcriptionally active viral core into the cytoplasm. The pathway used by reovirus to traverse the endocytic compartment is largely unknown. In this study, we found that reovirus particles traffic through early, late, and recycling endosomes during cell entry. After attachment to the cell surface, reovirus particles and JAM-A codistribute into each of these compartments. Transfection of cells with constitutively active and dominant-negative Rab GTPases that affect early and late endosome biogenesis and maturation influenced reovirus infectivity. In contrast, reovirus infectivity was not altered in cells expressing mutant Rab GTPases that affect recycling endosomes. Thus, reovirus virions localize to early, late, and recycling endosomes during entry into host cells, but only those that traverse early and late endosomes yield a productive infection.

  15. Early and late synovectomy of the knee in rheumatoid arthritis

    DEFF Research Database (Denmark)

    Jensen, C M; Poulsen, S; Ostergren, M

    1991-01-01

    The results after open knee synovectomy in the treatment of rheumatoid arthritis were investigated in a retrospective study including 44 patients with 55 knees. Median observation time was 73 months. Early synovectomy showed significant pain-relief and improvement of knee function, effusion...... treatment has failed. Late synovectomy must be regarded as a palliative procedure in order to postpone TKA....

  16. Plasma bilirubin and late graft failure in renal transplant recipients

    NARCIS (Netherlands)

    Deetman, Petronella E.; Zelle, Dorien M.; van der Heide, Jaap J. Homan; Navis, Gerjan J.; Gans, Reinold O. B.; Bakker, Stephan J. L.

    2012-01-01

    Exogenous bilirubin has been shown to protect against oxidative stress in ischemia-reperfusion injury. Oxidative stress has been implicated in the pathophysiology of chronic transplant dysfunction leading to late graft failure after renal transplantation. We prospectively investigated whether high e

  17. Antarctic and Southern Ocean influences on Late Pliocene global cooling

    NARCIS (Netherlands)

    McKay, R.; Naish, T.; Carter, L.; Riesselman, C.; Dunbar, R.; Sjunneskog, C.; Winter, D.; Sangiorgi, F.; Warren, C.; Pagani, M.; Schouten, S.; Willmot, V.; Levy, R.; DeConto, R.; Powell, R.D.

    2012-01-01

    The influence of Antarctica and the Southern Ocean on Late Pliocene global climate reconstructions has remained ambiguous due to a lack of well-dated Antarctic-proximal, paleoenvironmental records. Here we present ice sheet, sea-surface temperature, and sea ice reconstructions from the ANDRILL AND-1

  18. High paleotemperatures in the Late Cretaceous Arctic ocean

    NARCIS (Netherlands)

    Sinninghe Damsté, J.S.; Jenkyns, H.; Forster, A.; Schouten, S.

    2004-01-01

    To understand the climate dynamics of the warm, equable greenhouse world of the Late Cretaceous period, it is important to determine polar palaeotemperatures. The early palaeoceanographic history of the Arctic Ocean has, however, remained largely unknown, because the sea floor and underlying deposit

  19. Early and late pathogenesis of natural scrapie infection in sheep

    NARCIS (Netherlands)

    Keulen, van L.J.M.; Vromans, M.E.W.; Zijderveld, van F.G.

    2002-01-01

    The pathogenesis of scrapie infection was studied in sheep carrying the PrPVRQ/PrPVRQ genotype, which is associated with a high susceptibility for natural scrapie. The sheep were killed at sequential time points during a scrapie infection covering both the early and late stages of scrapie pathogenes

  20. Changes in tropical Late Carboniferous compression floras and their causes

    Energy Technology Data Exchange (ETDEWEB)

    Pfefferkorn, H.W. (Univ. of Pennsylvania, Philadelphia, PA (United States). Dept. of Geology)

    1992-01-01

    In the Late Carboniferous ten biostratigraphic boundaries can be recognized based on compression floras. Some of these boundaries coincide with classical stage boundaries whereas others do not. These boundaries are observable throughout Eurameria. In most cases the same species are involved in North America and Europe. Four boundaries are characterized by extinction events that involve only a few or many taxa. Four boundaries are characterized by origination of single taxa or by changes in the dominance of taxonomic groups. Two boundaries near the base of the Late Carboniferous seem to coincide with different stages in the onset of the ice age on Gondwanaland. However, it has not been clearly demonstrated what the local climatic signals in the tropics were. Three boundaries in the late Late Carboniferous are connected with well established trends toward dryer climate. It appears that many of these floral changes were climatically controlled. The actual triggering condition seems to have been produced by a variable combination of short term (allocyclic) and long term (orogeny, continental movement) effects. In one case the reason for the extinction is not obvious and could be biotic in nature.

  1. Two Late Iron Age warrior burials discovered in Kent

    Directory of Open Access Journals (Sweden)

    Casper Johnson

    2002-10-01

    Full Text Available Excavations by the Institute’s Field Archaeology Unit of a Late Iron Age and Early Romano-British site at Brisley Farm south of Ashford in Kent have revealed a pair of warrior burials (inhumations with weapons within square-ditch enclosures dated to AD 10–50. Here the excavation director describes this surprising discovery and discusses its significance.

  2. Dynamics of Perceived Parenting and Identity Formation in Late Adolescence

    Science.gov (United States)

    Beyers, Wim; Goossens, Luc

    2008-01-01

    Identity formation is a dynamic process of person-context interactions, and part of this context are parents, even in late adolescence. Several theories on parent-adolescent relationships share the idea that parents influence the process of identity formation. However, up to now, empirical evidence, particularly longitudinal evidence for this link…

  3. School Mobility during Childhood Predicts Psychotic Symptoms in Late Adolescence

    Science.gov (United States)

    Winsper, Catherine; Wolke, Dieter; Bryson, Alex; Thompson, Andrew; Singh, Swaran P.

    2016-01-01

    Background: Recently, school mobility was identified as a risk factor for psychotic symptoms in early adolescence. The extent to which this risk continues into late adolescence and the trajectories via which this risk manifests remain unexplored. Methods: Psychotic symptoms in 4,720 adolescents aged 18 were ascertained by trained psychologists…

  4. Predictors of future depression in early and late adolescence

    NARCIS (Netherlands)

    van Lang, Natasia D. J.; Ferdinand, Robert F.; Verhulst, Frank C.

    2007-01-01

    Background: This study examined whether the possibility to predict future DSM-IV depressive disorder can be increased with recurrent screening for depression in community adolescents, compared to single screening in early or in late adolescence. in addition, it examined which depressive symptoms in

  5. Occupational cognitive requirements and late-life cognitive aging

    NARCIS (Netherlands)

    Pool, Lindsay R.; Weuve, Jennifer; Wilson, Robert S.; Bultmann, Ute; Evans, Denis A.; de Leon, Carlos F. Mendes

    2016-01-01

    Objective:To examine whether occupational cognitive requirements, as a marker of adulthood cognitive activity, are associated with late-life cognition and cognitive decline.Methods:Main lifetime occupation information for 7,637 participants aged >65 years of the Chicago Health and Aging Project (CHA

  6. 5 CFR 2634.704 - Late filing fee.

    Science.gov (United States)

    2010-01-01

    ... supporting documentation. The designated agency ethics official's determination must be made in writing to....704 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT ETHICS EXECUTIVE BRANCH FINANCIAL...) Exceptions. (1) The designated agency ethics official may waive the late filing fee if he determines that...

  7. Mobile ICT use in early adopter vs. late majority countries

    DEFF Research Database (Denmark)

    Gimpel, Gregory; Sudzina, Frantisek; Petrovcikova, Katarina

    2016-01-01

    The rapid global diffusion of smartphones has not been uniform. This study uses Triandis’ theory of interpersonal behaviour to investigate what drives smartphone use in early adopter (USA) versus late majority (Slovakia) countries. By surveying both current and potential owners, we also revisit K...

  8. Word Parsing by Late-Learning French-English Bilinguals.

    Science.gov (United States)

    Golato, Peter

    2002-01-01

    Research on early learning French-English bilinguals suggests that development of segmentation is best characterized by a parameter-setting theory of language acquisition in which French segmentation is marked relative to English segmentation. Reports recent research with late-learning French-English bilinguals that finds evidence for parameter…

  9. Late endemic syphilis: case report of bejel with gummatous laryngitis.

    OpenAIRE

    Pace, J. L.; Csonka, G. W.

    1988-01-01

    An elderly Bedouin woman originally thought, on clinical and histological grounds, to have tuberculosis of the larynx was found to have gummatous laryngitis due to late endemic syphilis (bejel). This disease is highly prevalent in the Bedouin tribes of the Middle East. Doctors dealing with Arab patients, either in the Middle East or elsewhere, should be aware of this possibility.

  10. Late presentation of chronic viral hepatitis for medical care

    DEFF Research Database (Denmark)

    Mauss, Stefan; Pol, Stanislas; Buti, Maria

    2017-01-01

    INTRODUCTION: We present two consensus definitions of advanced and late stage liver disease being used as epidemiological tools. These definitions can be applied to assess the morbidity caused by liver diseases in different health care systems. We focus is on hepatitis B and C virus infections, b...

  11. Separation-Individuation of Late Adolescents : A Longitudinal Study

    Science.gov (United States)

    Aslan, Sevda; Gelbal, Selahattin

    2016-01-01

    The aim of this study was to demonstrate the change in separation-individuation between late adolescents in the first, second, third and fourth year of higher education. The study sample used for this longitudinal study consisted of 148 students attending class studies, computer education and science education departments of Kirikkale University.…

  12. Late entry to antenatal care in New South Wales, Australia

    Directory of Open Access Journals (Sweden)

    Rubin George

    2006-08-01

    Full Text Available Abstract Aims This study aimed to assess the prevalence of women who entered antenatal care (ANC late and to identify factors related to the late entry to ANC in New South Wales (NSW in 2004. Methods The NSW Midwives Data Collection contained data of 85,034 women who gave birth in 2004. Data were downloaded using SAS and transferred to STATA 8.0. Entering ANC after 12 weeks of gestation was classified as late. The Andersen Health Seeking Behaviour Model was used for selection and analyses of related factors. Regression and hierarchical analyses were used to identify significant factors and their relative contributions to the variation of pregnancy duration at entry to ANC. Results 41% of women commenced ANC after 12 weeks of gestation. Inequality existed between groups of women with predisposing characteristics and enabling resources contributed more to the variation in pregnancy duration at entry to ANC than needs. The groups of women with highest risk were teenagers, migrants from developing countries, women living in Western Sydney, Aboriginal and Torres Strait Islanders, women with three or more previous pregnancies and heavy smokers. The high risk groups with largest number of women were migrants from developing countries and women living in Western Sydney. Conclusion A large number of women in NSW entered ANC late in their pregnancies. Efforts to increase early entry to ANC should be targeted on identified high risk groups of women.

  13. Significant differences in late Quaternary bedrock erosion and transport

    DEFF Research Database (Denmark)

    Andrews, John; Bjørk, Anders Anker; Eberl, Dennis;

    2015-01-01

    We use quantitative X-ray diffraction to determine the mineralogy of late Quaternary marine sediments from the West and East Greenland shelves offshore from early Tertiary basalt outcrops. Despite the similar basalt outcrop area (60 000–70 000 km2), there are significant differences between East ...

  14. Late cardiovascular and neurological complications in Hodgkin lymphoma survivors

    NARCIS (Netherlands)

    van Leeuwen-Segarceanu, E.M.

    2013-01-01

    This thesis focuses on the early detection of cardiovascular and neurological abnormalities in Hodgkin Lymphoma Survivors (HLS) in a population of 82 patients and 40 controls and in a cross-sectional setting. Several screening test were performed for the assessment of these late effects of treatment

  15. Adaptive midlife defense mechanisms and late-life health.

    Science.gov (United States)

    Malone, Johanna C; Cohen, Shiri; Liu, Sabrina R; Vaillant, George E; Waldinger, Robert J

    2013-07-01

    A growing body of research suggests that personality characteristics relate to physical health; however, this relation ship has primarily been tested in cross-sectional studies that have not followed the participants into old age. The present study utilizes data from a 70-year longitudinal study to prospectively examine the relationship between the adaptive defense mechanisms in midlife and objectively assessed physical health in late life. In addition to examining the direct effect, we test whether social support mediates this relation ship. The sample consisted of 90 men who were followed for over seven decades beginning in late adolescence. Health ratings from medical records were made at three time points (ages 70, 75, and 80). Defense mechanisms were coded from narratives by trained independent raters (Vaillant, Bond, & Vaillant, 1986). Independent raters assessed social supports between ages 50 and 70. More adaptive defenses in midlife were associated with better physical health at all three time points in late life. These relationships were partially mediated by social support. Findings are consistent with the theory that defense maturity is important for building social relationships, which in turn contribute to better late-life physical health. Psychological interventions aimed at improving these domains may be beneficial for physical health.

  16. Late adverse reactions to intravascular iodine based contrast media

    DEFF Research Database (Denmark)

    Bellin, Marie-France; Stacul, Fulvio; Webb, Judith A W

    2011-01-01

    DEFINITION: Late adverse reactions (LAR) to contrast media (CM) are defined as reactions occurring 1 h to 1 week after exposure. NEED FOR REVIEW: In view of more prospective studies of LAR and new data about their pathophysiology, the Contrast Medium Safety Committee (CMSC) of the European Societ...

  17. A rhinoceros from the late miocene of Fort Ternan, Kenya

    NARCIS (Netherlands)

    Hooijer, D.A.

    1968-01-01

    SYNOPSIS A rhinoceros from the Fort Ternan site, Kenya, Late Miocene in age, represents a form distinctly more advanced than the genera and species known from the Early Miocene although it is not directly ancestral to the Quaternary forms. It is a collaterally developed tuskless, two-horned, browsin

  18. Early Embedding and Late Reranking for Video Captioning

    NARCIS (Netherlands)

    Dong, J.; Li, X.; Lan, W.; Huo, Y.; Snoek, C.G.M.

    2016-01-01

    This paper describes our solution for the MSR Video to Language Challenge. We start from the popular ConvNet + LSTM model, which we extend with two novel modules. One is early embedding, which enriches the current low-level input to LSTM by tag embeddings. The other is late reranking, for re-scoring

  19. Late degeneration in rabbit tissues after irradiation by heavy ions

    Science.gov (United States)

    Lett, J. T.; Cox, A. B.; Keng, P. C.; Lee, A. C.; Su, C. M.; Bergtold, D. S.

    1980-01-01

    Results are presented for investigations of the late effects of heavy-ion irradiation on rabbit tissues which were undertaken to assess the hazards associated with the long-term exposure of humans to heavy ions in space during such activities as the construction of solar power stations or voyages to Mars. White rabbits approximately six weeks old were exposed to various doses of collimated beams of 400-MeV/n Ne ions, 570 MeV/n Ar ions and Co-60 gamma rays directed through both eyes, and the responses of the various tissues (hair follicles, skin, cornea, lens, retina, Harderian glands, bone and forebrain) were examined. Proliferating tissues are found to exhibit high damage levels in the early and late periods following irradiation, while terminally differentiating tissues repond to radiation most intensely in the late period, years after irradiation, with no intermediate recovery. The results obtained from rabbits are used to predict the occurrence of late tissue degeneration in the central nervous system, terminally differentiating systems and stem cells of humans one or more decades following exposure to radiation levels anticipated during long-duration space flights. The studies also indicate that tissues may be prematurely aged in the sense that tissue life spans may be shortened without the development of malignancies.

  20. Late-Onset Hearing Loss: Strategies for Effective Counseling.

    Science.gov (United States)

    Smith, S. Mae; Kampfe, Charlene M.

    1999-01-01

    Late-onset hearing loss is one of the major chronic conditions experienced by older individuals. The term "presbycusis" is typically used when describing this condition. Presbycusis refers to many degenerative changes that affect older people's hearing. This article provides practical suggestions for working with persons with this…

  1. Late-time Spectroscopy of Type Iax Supernovae

    CERN Document Server

    Foley, Ryan J; Pan, Yen-Chen; Zheng, WeiKang; Bildsten, Lars; Filippenko, Alexei V; Kasen, Daniel

    2016-01-01

    We examine the late-time (t > 200 days after peak brightness) spectra of Type Iax supernovae (SNe Iax), a low-luminosity, low-energy class of thermonuclear stellar explosions observationally similar to, but distinct from, Type Ia supernovae. We present new spectra of SN 2014dt, resulting in the most complete published late-time spectral sequence of a SN Iax. At late times, SNe Iax have generally similar spectra, all with a similar continuum shape and strong forbidden-line emission. However, there is also significant diversity where some late-time SN Iax spectra display narrow P-Cygni features and a continuum indicative of a photosphere in addition to strong narrow forbidden lines, while others have no obvious P-Cygni features, strong broad forbidden lines, and weak narrow forbidden lines. Finally, some SNe Iax have spectra intermediate to these two varieties with weak P-Cygni features and broad/narrow forbidden lines of similar strength. We find that SNe Iax with strong broad forbidden lines also tend to be m...

  2. Dementia with impaired glucose metabolism in late onset metachromatic leukodystrophy

    DEFF Research Database (Denmark)

    Johannsen, P.; Ehlers, L.; Hansen, Hans Jacob

    2001-01-01

    An unusual case of very-late-onset metachromatic leukodystrophy (MLD) with dementia was studied. The patient was a 41-year-old male who presented with mild dementia and a single generalized tonic clonic seizure. Neuropsychological assessment demonstrated mild amnesia, visuospatial dysfunction...

  3. Strategies to control late blight in potatoes in Europe

    NARCIS (Netherlands)

    Schepers, H.T.A.M.; Evenhuis, A.; Spits, H.G.

    2009-01-01

    In Europe an aggressive genetically diverse population of potato late blight is present which regularly causes problems in all potato growing regions. It is therefore of the utmost importance that blight is managed in an integrated way by combining a range of measures. Hygiene measures can keep the

  4. High paleotemperatures in the Late Cretaceous Arctic ocean

    NARCIS (Netherlands)

    Sinninghe Damsté, J.S.; Jenkyns, H.; Forster, A.; Schouten, S.

    2004-01-01

    To understand the climate dynamics of the warm, equable greenhouse world of the Late Cretaceous period, it is important to determine polar palaeotemperatures. The early palaeoceanographic history of the Arctic Ocean has, however, remained largely unknown, because the sea floor and underlying deposit

  5. Radioactive demonstration of the ``late wash`` Precipitate Hydrolysis Process

    Energy Technology Data Exchange (ETDEWEB)

    Bibler, N.E.; Ferrara, D.M.; Ha, B.C.

    1992-06-30

    This report presents results of the radioactive demonstration of the DWPF Precipitate Hydrolysis Process as it would occur in the ``late wash`` flowsheet in the absence of hydroxylamine nitrate. Radioactive precipitate containing Cs-137 from the April, 1983, in-tank precipitation demonstration in Tank 48 was used for these tests.

  6. Etiology and pathogenesis of late-onset Alzheimer's disease.

    Science.gov (United States)

    Balin, Brian J; Hudson, Alan P

    2014-03-01

    Alzheimer's disease (AD) is a neurodegenerative condition that occurs in two forms, an early-onset form that is genetically determined and a far more common late-onset form that is not. In both cases, the disease results in severe cognitive dysfunction, among other problems, and the late-onset form of the disease is now considered to be the most common cause of dementia among the elderly. While a good deal of research has been focused on elucidating the etiology of the late-onset form for more than two decades, results to date have been modest and have not yet engendered useful therapeutic strategies for cure of the disease. In this review, we discuss the prevalent ideas that have governed this research for several years, and we challenge these ideas with alternative findings suggesting a multifactorial etiology. We review promising newer ideas that may prove effective as therapeutic interventions for late-onset AD, as well as providing reliable means of earlier and more specific diagnosis of the disease process. In the discussions included here, we reference relevant clinical and basic science literature underlying research into disease etiology and pathogenesis, and we highlight current reviews on the various topics addressed.

  7. Late-stage deoxyfluorination of alcohols with PhenoFluor.

    Science.gov (United States)

    Sladojevich, Filippo; Arlow, Sophie I; Tang, Pingping; Ritter, Tobias

    2013-02-20

    An operationally simple protocol for the selective deoxyfluorination of structurally complex alcohols is presented. Several fluorinated derivatives of natural products and pharmaceuticals have been prepared to showcase the potential of the method for late-stage diversification and its functional group compatibility. A series of simple guidelines for predicting the selectivity in substrates with multiple alcohols is given.

  8. Late Paleozoic paleolatitude and paleogeography of the Midland basin, Texas

    Energy Technology Data Exchange (ETDEWEB)

    Walker, D.A. (Mobil Exploration and Producing U.S., Midland, TX (United States)); Golonka, J. (Mobil Exploration and Producing Services Inc., Dallas, TX (United States)); Reid, A.M.; Reid, S.T. (Consulting Geologist, Midland, TX (United States))

    1992-04-01

    During the Late Pennsylvanian through Early Permian, the Midland basin was located in the low latitudes. In the Desmoinesian (Strawn), the basin was astride the equator; during the Missourian (Canyon), the center of the basin had migrated northward so it was located at 1-2N latitude. In the Virgilian (Cisco), the basin center was located around 2-4N latitude, and by the Wolfcampian, it was positioned at around 4-6N latitude. From the Desmoinesian (312 Ma) through the Missourian (306 Ma), the relative motion of the basin was 63NE. Later during the Virgilian (298 Ma) to Wolfcampian (280 Ma), the direction of motion was 24NE. This change in motion reflects a major tectonic event, occurring between the Missourian and Virgilian, that greatly modifed the movement of the Laurentian (North American) plate. At that time, Laurentia had collided with Gondwana and become part of the supercontinent Pangea. Throughout the late Paleozoic, Laurentia was rotated so the Midland basin was oriented 43{degree} northeast from its current setting. Late Paleozoic paleogeography and paleolatitude controlled the direction of prevailing winds and ocean currents, thereby influencing the distribution of carbonate facies in the Midland basin. Present prevailing winds and ocean currents have been shown to have a major impact on modern carbonate sedimentation and facies distribution in Belize, the Bahamas and Turks, and Caicos. A clearer understanding of how late Paleozoic latitude and geography affected sedimentation helps explain and predict the distribution of carbonates throughout the Midland basin.

  9. Late Proterozoic extensional collapse in the Arabian-Nubian Shield

    NARCIS (Netherlands)

    Blasband, B.B.; White, S.H.; Brooijmans, P.; Boorder, H. de; Visser, W.

    2000-01-01

    A structural and petrological study of the Late Proterozoic rocks in the Wadi Kid area, Sinai, Egypt indicates the presence of an extensional metamorphic core complex in the northern Arabian–Nubian Shield. Gneissic domes throughout the Arabian–Nubian Shield resemble the core complex of the Wadi Kid

  10. Can physiology help us to combat late blight in potato?

    NARCIS (Netherlands)

    Struik, P.C.

    2010-01-01

    Late blight is a devastating disease in potato production world-wide. Breeding for resistance is complex because of the versatile and aggressive population of Phytophthora infestans, which overcomes any new genetic source of resistance very rapidly. There are reliable fungicides available to control

  11. Material souls and imagination in late Aristotelian embryology.

    Science.gov (United States)

    Blank, Andreas

    2010-04-01

    This article explores some continuities between Late Aristotelian and Cartesian embryology. In particular, it argues that there is an interesting consilience between some accounts of the role of imagination in trait acquisition in Late Aristotelian and Cartesian embryology. Evidence for this thesis is presented using the extensive biological writings of the Padua-based philosopher and physician, Fortunio Liceti (1577-1657). Like the Cartesian physiologists, Liceti believed that animal souls are material beings and that acts of imagination result in material images that can be transmitted by means of medical spirits to the embryo. Moreover, while the Cartesian embryologists accepted such a view in a quite speculative way, one finds penetrating criticism of imagination theories of trait acquisition in the Late Aristotelian tradition. Evidence for this thesis is presented using the no less extensive biological writings of Liceti's contemporary, Emilio Parisano (1567-1643). In conclusion, the Late Aristotelian tradition itself provides the theoretical tools for excising immaterial formative forces from embryology and at the same time evinces a much more acute sense for the problems inherent in imagination theories of trait acquisition than the Cartesian tradition.

  12. 7 CFR 946.141 - Late payment and interest charge.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Late payment and interest charge. 946.141 Section 946... payment and interest charge. The Committee shall impose an interest charge on any handler who fails to pay... unpaid assessment balance. In the event the handler fails to pay the delinquent assessment, the one...

  13. Socioeconomic Status, English Proficiency, and Late-Emerging Reading Difficulties

    Science.gov (United States)

    Kieffer, Michael J.

    2010-01-01

    Educators have growing concerns about students who learn to read proficiently by third grade but fall behind in later grades. This study investigates the prevalence of "late-emerging" reading difficulties among English language learners (ELLs) and native English speakers from diverse socioeconomic backgrounds, using longitudinal data on…

  14. The epidemiology of acne vulgaris in late adolescence.

    Science.gov (United States)

    Lynn, Darren D; Umari, Tamara; Dunnick, Cory A; Dellavalle, Robert P

    2016-01-01

    Acne vulgaris is the most common skin condition affecting late adolescents across the globe. Although prior studies have evaluated epidemiologic patterns of acne vulgaris in various ethnicities and regions, adequate understanding of the worldwide burden of the disease associated with patients in their late adolescence (15-19-year olds) remains lacking. To assess the global burden of the disease associated with acne vulgaris for late adolescents (15-19-year olds) and provide an overview of the epidemiology, pathophysiology, and treatment options for acne in this population. Database summary study. Global Burden of Disease Study 2010 database. Global Burden of Disease regions comprised countries with prevalence of acne vulgaris between the ages of 15 and 19 years. Geographic region-level disability-adjusted life year rates (per 100,000 persons) associated with acne vulgaris in years 1990 through 2010. Median percentage change in disability-adjusted life year rates was estimated for each region across the specified study period. Acne vulgaris-associated disease burden exhibits global distribution and has continued to grow in prevalence over time within this population. This continued growth suggests an unmet dermatologic need worldwide for this disorder and potential opportunities for improved access and delivery of dermatologic care. Our analysis of the literature reveals numerous opportunities for enhanced patient care. To that end, we highlight some of the effective and promising treatments currently available and address important factors, such as sex, nationality, genetics, pathophysiology, and diet, as they relate to acne vulgaris in late adolescence.

  15. Late Adolescent Girls' Sexual Experiences and Sexual Satisfaction

    Science.gov (United States)

    Impett, Emily A.; Tolman, Deborah L.

    2006-01-01

    This study presented and tested a model of sexual satisfaction for late adolescent girls. In this model, sexual self-concept and approach sexual motives were tested as predictors of adolescent girls' sexual satisfaction with their most recent experience of sexual intercourse. A total of 116 girls in 12th grade (ages 16-19) completed measures of…

  16. Divorce Counseling Guidelines for the Late Divorced Female.

    Science.gov (United States)

    Langelier, Regis; Deckert, Pamela

    1980-01-01

    Offers divorce counseling guidelines for the female who divorces after 20 years or more of marriage, based on a 1977 study of late divorced female Canadians. Research emphasizes six major life adjustment areas: emotions; divorce grounds; finances and budgeting; children; life-style change; and independence. (Author)

  17. Financial Conflicts Facing Late-Life Remarried Alzheimer's Disease Caregivers

    Science.gov (United States)

    Sherman, Carey Wexler; Bauer, Jean W.

    2008-01-01

    This qualitative study explores financial conflicts faced by late-life remarried wives providing care for their husbands with Alzheimer's disease. Interviews with 9 women identified intergenerational secrets and tensions regarding financial and inheritance decisions. Participants' remarried spouse status, underlying family boundary ambiguities,…

  18. Pseudoxanthoma elasticum: Description of a late onset case

    Directory of Open Access Journals (Sweden)

    Baglieri Francesco

    2010-01-01

    Full Text Available Pseudoxanthoma elasticum (PXE is a genetic multisystem disorder characterized by ectopic mineralization of connective tissues with primary manifestations in the skin, retina and cardiovascular system, and a phenotypic spectrum highly variable.This article presents the case of a 46-year-old male patient with sporadic late-onset PXE, without severe systemic complications.

  19. Mobile ICT use in early adopter vs. late majority countries

    DEFF Research Database (Denmark)

    Gimpel, Gregory; Sudzina, Frantisek; Petrovcikova, Katarina

    2016-01-01

    The rapid global diffusion of smartphones has not been uniform. This study uses Triandis’ theory of interpersonal behaviour to investigate what drives smartphone use in early adopter (USA) versus late majority (Slovakia) countries. By surveying both current and potential owners, we also revisit K...

  20. Natural History in Hispanic Journalism in the Late Eighteenth Century

    Directory of Open Access Journals (Sweden)

    Arturo MORGADO GARCÍA

    2014-02-01

    Full Text Available In the Hispanic world of the late Eighteenth Century there was a certain amount of divulgation of Natural History, aided by the utilitarian nature of the Spanish Enlightenment, and by the fact that Natural History did not contradict Catholic doctrine. This paper approaches the diffusion of news of Natural History through periodicals, focusing on zoological references.

  1. Late renal dysfunction in adult survivors of bone marrow transplantation

    Energy Technology Data Exchange (ETDEWEB)

    Lawton, C.A.; Cohen, E.P.; Barber-Derus, S.W.; Murray, K.J.; Ash, R.C.; Casper, J.T.; Moulder, J.E. (Medical College of Wisconsin Affiliated Hospitals, Milwaukee (USA))

    1991-06-01

    Until recently long-term renal toxicity has not been considered a major late complication of bone marrow transplantation (BMT). Late renal dysfunction has been described in a pediatric population status post-BMT which was attributable to the radiation in the preparatory regimen. A thorough review of adults with this type of late renal dysfunction has not previously been described. Fourteen of 103 evaluable adult patients undergoing allogeneic (96) or autologous (7) bone marrow transplantation, predominantly for leukemia and lymphomas, at the Medical College of Wisconsin (Milwaukee, WI) have had a syndrome of renal insufficiency characterized by increased serum creatinine, decreased glomerular filtration rate, anemia, and hypertension. This syndrome developed at a median of 9 months (range, 4.5 to 26 months) posttransplantation in the absence of specific identifiable causes. The cumulative probability of having this renal dysfunction is 20% at 1 year. Renal biopsies performed on seven of these cases showed the endothelium widely separated from the basement membrane, extreme thickening of the glomerular basement membrane, and microthrombi. Previous chemotherapy, antibiotics, and antifungals as well as cyclosporin may add to and possibly potentiate a primary chemoradiation marrow transplant renal injury, but this clinical syndrome is most analogous to clinical and experimental models of radiation nephritis. This late marrow transplant-associated nephritis should be recognized as a potentially limiting factor in the use of some intensive chemoradiation conditioning regimens used for BMT. Some selective attenuation of the radiation to the kidneys may decrease the incidence of this renal dysfunction.

  2. Control of Late Blight of Tomato and Potato by Oilgochitosan

    Directory of Open Access Journals (Sweden)

    Yong Ho Choi

    2011-08-01

    Full Text Available Chitosan is a linear polysaccharide composed of randomly distributed β-(1-4-linked D-glucosamine and Nacetyl- D-glucosamine. There have been many reports on the induced systemic resistance and in vivo antifungal activities of higher molecular weight chitosans with molecular weights over 3,000 amu (atomatic mass unit, but there are few papers on in vivo antifungal activities of low molecular weight chitosans (oligochitosans with molecular weights less than 3,000 amu. In our study, an oligochitosan sample (320?3,000 amu showed a potent 1-day protective activity with control values more than 94% at concentrations of 500 and 1,000 ?g/ml especially against tomato late blight caused by Phytophthora infestans under growth chamber conditions. It also displayed a moderate 1-day protective activity with control values of 67?89% at concentrations of 500 and 1,000 ?g/ml against wheat leaf rust and red pepper anthracnose. On the other hand, it showed a 16-hr curative activity against red pepper anthracnose, but not against tomato late blight and wheat leaf rust. In field experiments, oligochitosan effectively suppressed the development of late blight on potato and tomato plants with control values of 72% and 48%, respectively. The results strongly indicate that oligochitosan can be used as an eco-friendly organic material for the control of late blight on tomato and potato plants.

  3. Late presentation of developmental dysplasia of the hip.

    LENUS (Irish Health Repository)

    Gul, R

    2012-02-03

    BACKGROUND: A neonatal screening programme for developmental dysplasia of the hip (DDH) is ongoing in Cork. Despite early screening, infants continue to present at later ages with DDH. The impact of late diagnosis is significant. Established DDH causes significant morbidity and may have major medicolegal implications. AIM: To identify the reasons for the late presentation of DDH in the presence of a screening programme. METHODS: In a retrospective study all cases of late DDH presenting from 1988 to 2000 were identified using inpatient database. RESULTS: Forty-nine cases of DDH were diagnosed. The mean age of diagnosis was 14.8 months (range 6-47). Multiple risk factors were identified in four patients only. More than one risk factor was identified in 10 patients. CONCLUSION: Despite screening, children continue to present with late DDH. In this study, only 14 patients had multiple risk factors and only four patients had more than two risk factors, highlighting the low incidence of suspicion in this patient group.

  4. Did intense volcanism trigger the first Late Ordovician icehouse?

    Science.gov (United States)

    Buggisch, Werner; Joachimski, Michael M.; Lehnert, Oliver; Bergström, Stig M.; Repetski, John E.; Webers, Gerald F.

    2010-01-01

    Oxygen isotopes measured on Late Ordovician conodonts from Minnesota and Kentucky (United States) were studied to reconstruct the paleotemperature history during late Sandbian to Katian (Mohawkian–Cincinnatian) time. This time interval was characterized by intense volcanism, as shown by the prominent Deicke, Millbrig, and other K-bentonite beds. A prominent carbon isotope excursion (Guttenberg δ13C excursion, GICE) postdates the Millbrig volcanic eruptions, and has been interpreted to reflect a drawdown of atmospheric carbon dioxide and climatic cooling. The oxygen isotope record in conodont apatite contradicts this earlier interpretation. An increase in δ18O of 1.5‰ (Vienna standard mean ocean water) just above the Deicke K-bentonite suggests an abrupt and short-lived cooling that possibly initiated a first short-term glacial episode well before the major Hirnantian glaciation. The decrease in δ18O immediately after the mega-eruptions indicates warming before the GICE, and no cooling is shown in the GICE interval. The coincidence of the Deicke mega-eruption with a cooling event suggests that this major volcanic event had a profound effect on Late Ordovician (late Mohawkian) climate.

  5. Late Miocene Sciuridae (Mammalia, Rodentia) from Anatolia, Turkey

    NARCIS (Netherlands)

    Bosma, A.A.; de Bruijn, H.; Wessels, W.

    Isolated cheek teeth of Sciuridae (Rodentia, Mammalia) from nine late Miocene localities in central Anatolia (Turkey) are described. The teeth represent at least 12 different species, five of which belong to the ground squirrel genus Tamias, two to the ground squirrel genus Spermophilinus, one to

  6. Hepatic late adverse effects after antineoplastic treatment for childhood cancer

    NARCIS (Netherlands)

    Mulder, Renee L.; van Dalen, Elvira C.; Van den Hof, Malon; Bresters, Dorine; Koot, Bart G. P.; Castellino, Sharon M.; Loke, Yoon; Leclercq, Edith; Post, Piet N.; Caron, Huib N.; Postma, Aleida; Kremer, Leontien C. M.

    2011-01-01

    Background Survival rates have greatly improved as a result of more effective treatments for childhood cancer. Unfortunately the improved prognosis has resulted in the occurrence of late, treatment-related complications. Liver complications are common during and soon after treatment for childhood ca

  7. Vps1 in the late endosome-to-vacuole traffic

    Indian Academy of Sciences (India)

    Jacob Hayden; Michelle Williams; Ann Granich; Hyoeun Ahn; Brandon Tenay; Joshua Lukehart; Chad Highfill; Sarah Dobard; Kyoungtae Kim

    2013-03-01

    Vacuolar protein sorting 1 (Vps1), the yeast homolog to human dynamin, is a GTP hydrolyzing protein, which plays an important role in protein sorting and targeting between the Golgi and late endosomal compartments. In this study, we assessed the functional significance of Vps1 in the membrane traffic towards the vacuole. We show here that vps1 cells accumulated FM4-64 to a greater extent than wild-type (WT) cells, suggesting slower endocytic degradation traffic toward the vacuole. In addition, we observed that two endosome-to-vacuole traffic markers, DsRed-FYVE and Ste2-GFP, were highly accumulated in Vps1-deficient cells, further supporting Vps1’s implication in efficient trafficking of endocytosed materials to the vacuole. Noteworthy, a simultaneous imaging analysis in conjunction with FM4-64 pulse-chase experiment further revealed that Vps1 plays a role in late endosome to the vacuole transport. Consistently, our subcellular localization analysis showed that Vps1 is present at the late endosome. The hyperaccumulation of endosomal intermediates in the vps1 mutant cells appears to be caused by the disruption of integrity of HOPS tethering complexes, manifested by mislocalization of Vps39 to the cytoplasm. Finally, we postulate that Vps1 functions together with the Endosomal Sorting Complex Required for Transport (ESCRT) complex at the late endosomal compartments, based on the observation that the double mutants, in which VPS1 along with singular ESCRT I, II and III genes have been disrupted, exhibited synthetic lethality. Together, we propose that Vps1 is required for correct and efficient trafficking from the late endosomal compartments to the vacuole.

  8. Late Quaternary environments and biogeography in the Great Basin

    Science.gov (United States)

    Thompson, R. S.; Mead, J. I.

    1982-01-01

    Plant and animal remains found in packrat ( Neotoma spp.) middens and cave fill from the eastern and southern Great Basin region reveal the presence of subalpine conifers and boreal mammals at relatively low elevations during the Late Wisconsin. Limber pine ( Pinus flexilis) and bristlecone pine ( P. longaeva) were important in the late Pleistocene plant communities throughout this region. Spruce ( Picea cf. engelmannii) and common juniper ( Juniperus communis) were present in some of the more northerly localities, and Douglas fir ( Pseudotsuga menziesii) and white fir ( Abies concolor) were present in southern and eastern localities. Single needle pinyon pine ( Pinus monophylla), common across this region today, was apparently not present north of the Sheep Range of southern Nevada during the Late Wisconsin. Pikas ( Ochotona cf. princeps), small boreal mammals present in only a few Great Basin mountain ranges today, were common throughout the region. Heather voles ( Phenacomys cf. intermedius) have been found in two cave fill deposits in Nevada, though they are unknown in the Great Basin today. Limber and bristlecone pines are generally restricted to rocky substrates in modern subalpine habitats in the Great Basin, and this may also have been the case when these plants grew at lower elevations during the Late Wisconsin. Subalpine conifers were present on the rock outcrops sampled by the packrat middens, but shrub communities, perhaps dominated by sagebrush ( Artemisia spp.), may have been present on alluvial valley-bottom substrates. Forested habitats would thus have been isolated habitat islands, as they are today. Boreal small mammals, including pikas and heather voles, were able to colonize the Great Basin mountain ranges during the late Pleistocene. We suggest that these mammals were able to survive in the intervening valley-bottoms under a cool-summer climatic regime, and that continuous forest or woodland corridors were not necessary for migration.

  9. Acute and late toxicity in radical radiotherapy of prostate cancer

    Directory of Open Access Journals (Sweden)

    Josifovski Tatjana

    2009-01-01

    Full Text Available Introduction. Although radical radiotherapy has proved to be a successful method in prostate cancer treatment, the conventional (box technique can result in significant adverse events. Objective. The objective of our study was to estimate the frequency, type and severity of acute and late toxicity in radical radiotherapy of prostate cancer. Methods. In a clinical retrospective study, we included 283 patients with histologically confirmed prostate cancer. All our patients received radical, conventional radiotherapy using the four-field technique. The study was performed at the Radiotherapy Department of the Institute for Oncology and Radiology of Serbia between January 1991 and December 2005. During regular follow-up, we analyzed the frequency, type and severity of acute and late toxicity. Results. Two thirds (71% of our patients had acute toxicity of at least one organ within the radiation field. Most frequent complication was radiation dermatitis (10.5%, and enteritis (9%, cystitis (6% and proctitis (2.5%. Acute adverse events were mostly low grade (I and II, 28-61%. Late complications were registered in 20.5% of patients. Skin fibrosis was most frequent (12%. Chronic proctitis was detected in 4% and urethral stricture in 4.5% of our patients. All late complications were low grade. Conclusion. Treatment tolerance of radical radiotherapy is relatively good. Although most patients develop acute toxicity, it is commonly low grade and requires the interruption of radiotherapy treatment in 20% of patients only. Late toxicity is rarer than acute and, in most cases, it does not affect the quality of life.

  10. Late Posthemorrhagic Structural and Functional Changes in Pulmonary Circulation Arteries

    Directory of Open Access Journals (Sweden)

    S. A. Andreyeva

    2008-01-01

    Full Text Available Objective: to reveal the major regularities and mechanisms of morphological changes in the rat pulmonary circulation arteries in the late posthemorrhagic period and to compare them with age-related features of the vessels. Materials and methods: experiments to generate graduated hemorrhagic hypotension with the blood pressure being maintained at 40 mm Hg were carried out on young (5—6-month albino male Wistar rats. Throughout hypotension and 60 days after blood loss, the blood was tested to determine low and average molecular-weight substances by spectrophotometry and the pro- and antioxidative systems by chemiluminescence. Pulmonary circulation arteries were morphologically studied in young animals, rats in the late posthemorrhagic period and old (24—25-month rats. Results. Sixty-minute hemorrhagic hypotension leads to the development of endotoxemia and imbalance of the pro- and antioxidative systems, the signs of which are observed in the late periods (2 months after hypotension. At the same time, the posthemorrhagic period is marked by the significant pulmonary circulation arterial morphological changes comparable with their age-related alterations in old rat. This shows up mainly in the reorganization of a connective tissue component in the vascular wall: the elevated levels of individual collagen fibers, their structural changes, elastic medial membrane destruction and deformity. At the same time, there is a change in the morphometric parameters of vessels at all study stages while their lowered flow capacity is only characteristic for intraorgan arteries. Conclusion: The increased activity of free radical oxidation and endotoxemia may be believed to be one of the causes of morphological changes in pulmonary circulation arteries in the late posthemorrhagic period, which is similar to age-related vascular alterations. Key words: hemorrhagic hypotension, pulmonary circulation arteries, free radical oxidation, endotoxemia, remodeling, late

  11. Late Language Emergence in 24-Month-Old Twins: Heritable and Increased Risk for Late Language Emergence in Twins

    Science.gov (United States)

    Rice, Mabel L.; Zubrick, Stephen R.; Taylor, Catherine L.; Gayán, Javier; Bontempo, Daniel E.

    2014-01-01

    Purpose: This study investigated the etiology of late language emergence (LLE) in 24-month-old twins, considering possible twinning, zygosity, gender, and heritability effects for vocabulary and grammar phenotypes. Method: A population-based sample of 473 twin pairs participated. Multilevel modeling estimated means and variances of vocabulary and…

  12. Sedimentary architecture and chronostratigraphy of a late Quaternary incised-valley fill: A case study of the late Middle and Late Pleistocene Rhine system in the Netherlands

    Science.gov (United States)

    Peeters, J.; Busschers, F. S.; Stouthamer, E.; Bosch, J. H. A.; Van den Berg, M. W.; Wallinga, J.; Versendaal, A. J.; Bunnik, F. P. M.; Middelkoop, H.

    2016-01-01

    This paper describes the sedimentary architecture, chronostratigraphy and palaeogeography of the late Middle and Late Pleistocene (Marine Isotope Stage/MIS 6-2) incised Rhine-valley fill in the central Netherlands based on six geological transects, luminescence dating, biostratigraphical data and a 3D geological model. The incised-valley fill consists of a ca. 50 m thick and 10-20 km wide sand-dominated succession and includes a well-developed sequence dating from the Last Interglacial: known as the Eemian in northwest Europe. The lower part of the valley fill contains coarse-grained fluvio-glacial and fluvial Rhine sediments that were deposited under Late Saalian (MIS 6) cold-climatic periglacial conditions and during the transition into the warm Eemian interglacial (MIS 5e-d). This unit is overlain by fine-grained fresh-water flood-basin deposits, which are transgressed by a fine-grained estuarine unit that formed during marine high-stand. This ca. 10 m thick sequence reflects gradual drowning of the Eemian interglacial fluvial Rhine system and transformation into an estuary due to relative sea-level rise. The chronological data suggests a delay in timing of regional Eemian interglacial transgression and sea-level high-stand of several thousand years, when compared to eustatic sea-level. As a result of this glacio-isostatic controlled delay, formation of the interglacial lower deltaic system took only place for a relative short period of time: progradation was therefore limited. During the cooler Weichselian Early Glacial period (MIS 5d-a) deposition of deltaic sediments continued and extensive westward progradation of the Rhine system occurred. Major parts of the Eemian and Weichselian Early Glacial deposits were eroded and buried as a result of sea-level lowering and climate cooling during the early Middle Weichselian (MIS 4-3). Near complete sedimentary preservation occurred along the margins of the incised valley allowing the detailed reconstruction presented

  13. PRR11 regulates late-S to G2/M phase progression and induces premature chromatin condensation (PCC)

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Chundong; Zhang, Ying; Li, Yi; Zhu, Huifang; Wang, Yitao; Cai, Wei [Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing 400016 (China); Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016 (China); Zhu, Jiang [Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016 (China); Ozaki, Toshinori [Laboratory of DNA Damage Signaling, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuohku, Chiba 260-8717 (Japan); Bu, Youquan, E-mail: buyqcn@aliyun.com [Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing 400016 (China); Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016 (China)

    2015-03-13

    Recently, we have demonstrated that proline-rich protein 11 (PRR11) is a novel tumor-related gene product likely implicated in the regulation of cell cycle progression as well as lung cancer development. However, its precise role in cell cycle progression remains unclear. In the present study, we have further investigated the expression pattern and functional implication of PRR11 during cell cycle in detail in human lung carcinoma-derived H1299 cells. According to our immunofluorescence study, PRR11 was expressed largely in cytoplasm, the amount of PRR11 started to increase in the late S phase, and was retained until just before mitotic telophase. Consistent with those observations, siRNA-mediated knockdown of PRR11 caused a significant cell cycle arrest in the late S phase. Intriguingly, the treatment with dNTPs further augmented PRR11 silencing-mediated S phase arrest. Moreover, knockdown of PRR11 also resulted in a remarkable retardation of G2/M progression, and PRR11-knockdown cells subsequently underwent G2 phase cell cycle arrest accompanied by obvious mitotic defects such as multipolar spindles and multiple nuclei. In addition, forced expression of PRR11 promoted the premature Chromatin condensation (PCC), and then proliferation of PRR11-expressing cells was massively attenuated and induced apoptosis. Taken together, our current observations strongly suggest that PRR11, which is strictly regulated during cell cycle progression, plays a pivotal role in the regulation of accurate cell cycle progression through the late S phase to mitosis. - Highlights: • PRR11 started to increase in the late S phase and was retained until just before mitotic telophase. • PRR11-knockdown caused a significant cell cycle arrest in the late S phase and G2 phase. • The treatment with dNTPs further augmented PRR11 silencing-mediated S phase arrest. • PRR11-knockdown led to multipolar spindles and multiple nuclei. • Forced expression of PRR11 promoted the PCC and inhibited

  14. HEARING AND VISUAL IMPAIRMENTSAS RISK FACTORS FOR LATE- LIFE DEPRESSION

    Directory of Open Access Journals (Sweden)

    Roza N. KRSTESKA

    2012-03-01

    Full Text Available Introduction: Late-life depression is one of the most frequent disorders among the seniors and often remains unrecognized. One of the reasons why late-life depression often passes unrecognized is the comorbidity. Hearing and visual impairments are very common condition among the elderly. Thus, depression among the elderly is commonly accompanied by hearing and visual impairment. The epidemiology together with the visual and hearing-related problems still remains poorly investigated.Objective: The aim of the study was to evaluate the relationship between hearing and visual function and the late-life depression.Methods: This was a cross-sectional study with a random sample of 120 participants, 60 patients with late-life depression and 60 community-dwelling older adults aged over 60 and without the symptoms of depression. All participants were examined using a questionnaire designed for the aim of the study to measure the severity of the symptoms (scale with scores from 1 to 3 - from mild to profound degree of self-reported hearing and visual impairment. In addition, existing medical records and the Geriatric Depression Scale were used as well.Results: The patients with late-life depression in larger number suffered from hearing and visual impairment compared to the non - depressed elderly people: hearing impairments (χ2=6.97, df=1, p=0.0083 and visual impairments (χ2=4.37, df=2, p=0.012.Conclusion: These data suggest that the risk of late-life depression is higher among elderly patients with hearing and visual impairment. A comprehensive annual eye exam is the most important step that can be undertaken to help monitor and protect normal visual function in the elderly. It is necessary to conduct routine screening and early treatment of depression in elderly patients with hearing and visual impairment within the primary care practice. Ophthalmologists and otologists should be aware of the need for routine screening for geriatric syndromes in the

  15. A new carnivorous dinosaur from the Late Jurassic Solnhofen archipelago.

    Science.gov (United States)

    Göhlich, Ursula B; Chiappe, Luis M

    2006-03-16

    Small Late Jurassic theropod dinosaurs are rare worldwide. In Europe these carnivorous dinosaurs are represented primarily by only two skeletons of Compsognathus, neither of which is well preserved. Here we describe a small new theropod dinosaur from the Late Jurassic period of Schamhaupten in southern Germany. Being exquisitely preserved and complete from the snout to the distal third of the tail, the new fossil is the best-preserved predatory, non-avian dinosaur in Europe. It possesses a suite of characters that support its identification as a basal coelurosaur. A cladistic analysis indicates that the new taxon is closer to maniraptorans than to tyrannosauroids, grouping it with taxa often considered to be compsognathids. Large portions of integument are preserved along its tail. The absence of feathers or feather-like structures in a fossil phylogenetically nested within feathered theropods indicates that the evolution of these integumentary structures might be more complex than previously thought.

  16. Brane gas cosmology in M-theory late time behavior

    CERN Document Server

    Easther, R; Jackson, M G; Kabat, D; Easther, Richard; Greene, Brian R.; Jackson, Mark G.; Kabat, Daniel

    2003-01-01

    We investigate the late-time behavior of a universe containing a supergravity gas and wrapped 2-branes in the context of M-theory compactified on T^10. The supergravity gas tends to drive uniform expansion, while the branes impede the expansion of the directions about which they are wrapped. Assuming spatial homogeneity, we study the dynamics both numerically and analytically. At late times the radii obey power laws which are determined by the brane wrapping numbers, leading to interesting hierarchies of scale between the wrapped and unwrapped dimensions. The biggest hierarchy that could evolve from an initial thermal fluctuation produces three large unwrapped dimensions. We also study configurations corresponding to string winding, in which the M2-branes are all wrapped around the (small) 11th dimension, and show that this recovers the scenario discussed by Brandenberger and Vafa.

  17. "Redo" surgery for late aorto-femoral graft occlusive failures.

    Science.gov (United States)

    Benhamou, A C; Kieffer, E; Tricot, J F; Maraval, M; Le Thoai, M; Natali, J

    1984-01-01

    Experience of late failures of Dacron aortofemoral grafts is presented; about 70 cases observed during the past eight years on whom 105 subsequent operations were performed. One third of these patients were first operated upon by another surgical team. During the same period, 850 patients were submitted to reconstructive surgery of the abdominal aorta and iliac arteries either for atherosclerotic or for aneurysmal disease. It appears that conservative procedures like thrombectomy of the occluded limb are often insufficient, impossible, inappropriate or dangerous, even after restoration of a good deep femoral outflow. On the other hand, aggressive restoration of limbflow is generally necessary, with other various and ingenious direct or indirect reconstructive techniques for restitution of a good inflow and outflow. These techniques are usually successful (85%) and gain time against the major etiology of these late failures viz the development of atherosclerotic disease.

  18. [Late neck metastasis in esthesioneuroblastoma: a case report].

    Science.gov (United States)

    Damar, Murat; Başerer, Nermin; Ozkara, Selvinaz; Yılmazer, Rasim

    2012-01-01

    Esthesioneuroblastoma is a rare malignancy of olfactory neuroepithelium arising from sinonasal region. It has biologically an aggressive behavior. The tumor is characterised by common local recurrence, atypic distant metastasis and poor long-term prognosis. Cervical metastasis accounts for 20-30% of the patients. Late metastases are seen particularly six months or later following primary treatment. In this article, we present a 43-year-old female case with Kadish B stage esthesioneuroblastoma who underwent extracranial tumor resection and postoperative radiotherapy. Eleven years later (at 132 months) right neck cervical metastasis was occurred and we applied right functional neck dissection and adjuvant radiotherapy to treat. We also review the treatment of late neck metastasis in the light of the current literature data.

  19. Epidemiology and integrated control of potato late blight in Europe

    DEFF Research Database (Denmark)

    Cooke, L R; Schepers, H T A M; Hermansen, A

    2011-01-01

    Phytophthora infestans, the causal agent of late blight, is a major threat to potato production in northwestern Europe. Before 1980, the worldwide population of P. infestans outside Mexico appeared to be asexual and to consist of a single clonal lineage of A1 mating type characterized by a single...... 20 years. The relative importance of the different primary inoculum sources and specific measures for reducing their role, such as covering dumps with plastic and preventing seed tubers from becoming infected, is described for the different regions. In NW Europe, varieties with greater resistance...... tend not to be grown on a large scale. From the grower’s perspective, the savings in fungicide input that can be achieved with these varieties are not compensated by the higher (perceived) risk of blight. Fungicides play a crucial role in the integrated control of late blight. The spray strategies...

  20. Role of rice PPS in late vegetative and reproductive growth.

    Science.gov (United States)

    Tanaka, Nobuhiro; Itoh, Jun-Ichi; Nagato, Yasuo

    2012-01-01

    The rice peter pan syndrome-1 (pps-1) mutant shows a prolonged juvenile phase and early flowering. Although the early vegetative phase and flowering time of pps-1 have been closely examined, the phenotypes in the late vegetative and reproductive phases are not yet well understood. In the ninth leaf blade of pps-1, the relative length of the midrib was comparable to the sixth leaf blade of wild-type. Moreover, pps-1 had a small inflorescence meristem and small panicles. These phenotypes indicate that in pps-1 the juvenile phase coexists with the late vegetative phase, resulting in small panicles. Gibberellin is known to promote the juvenile-adult phase transition. d18-k is dwarf and has a prolonged juvenile phase. Double mutant (d18-k pps-1) showed the same phenotype as the pps-1, indicating that PPS is upstream of GA biosynthetic genes.

  1. Late Cretaceous-Early Palaeogene tectonic development of SE Asia

    Science.gov (United States)

    Morley, C. K.

    2012-10-01

    The Late Cretaceous-Early Palaeogene history of the continental core of SE Asia (Sundaland) marks the time prior to collision of India with Asia when SE Asia, from the Tethys in the west to the Palaeo-Pacific in the east, lay in the upper plate of subduction zones. In Myanmar and Sumatra, subduction was interrupted in the Aptian-Albian by a phase of arc accretion (Woyla and Mawgyi arcs) and in Java, eastern Borneo and Western Sulawesi by collision of continental fragments rifted from northern Australia. Subsequent resumption of subduction in the Myanmar-Thailand sector explains: 1) early creation of oceanic crust in the Andaman Sea in a supra-subduction zone setting ~ 95 Ma, 2) the belt of granite plutons of Late Cretaceous-Early Palaeogene age (starting ~ 88 Ma) in western Thailand and central Myanmar, and 3) amphibolite grade metamorphism between 70 and 80 Ma seen in gneissic outcrops in western and central Thailand, and 4) accretionary prism development in the Western Belt of Myanmar, until glancing collision with the NE corner of Greater India promoted ophiolite obduction, deformation and exhumation of marine sediments in the early Palaeogene. The Ranong strike-slip fault and other less well documented faults, were episodically active during the Late Cretaceous-Palaeogene time. N to NW directed subduction of the Palaeo-Pacific ocean below Southern China, Vietnam and Borneo created a major magmatic arc, associated with rift basins, metamorphic core complexes and strike-slip deformation which continued into the Late Cretaceous. The origin and timing of termination of subduction has recently been explained by collision of a large Luconia continental fragment either during the Late Cretaceous or Palaeogene. Evidence for such a collision is absent from the South China Sea well and seismic reflection record and here collision is discounted. Instead relocation of the subducting margin further west, possibly in response of back-arc extension (which created the Proto

  2. Stochastic late accretion to Earth, the Moon, and Mars.

    Science.gov (United States)

    Bottke, William F; Walker, Richard J; Day, James M D; Nesvorny, David; Elkins-Tanton, Linda

    2010-12-10

    Core formation should have stripped the terrestrial, lunar, and martian mantles of highly siderophile elements (HSEs). Instead, each world has disparate, yet elevated HSE abundances. Late accretion may offer a solution, provided that ≥0.5% Earth masses of broadly chondritic planetesimals reach Earth's mantle and that ~10 and ~1200 times less mass goes to Mars and the Moon, respectively. We show that leftover planetesimal populations dominated by massive projectiles can explain these additions, with our inferred size distribution matching those derived from the inner asteroid belt, ancient martian impact basins, and planetary accretion models. The largest late terrestrial impactors, at 2500 to 3000 kilometers in diameter, potentially modified Earth's obliquity by ~10°, whereas those for the Moon, at ~250 to 300 kilometers, may have delivered water to its mantle.

  3. Evidence for global cooling in the Late Cretaceous.

    Science.gov (United States)

    Linnert, Christian; Robinson, Stuart A; Lees, Jackie A; Bown, Paul R; Pérez-Rodríguez, Irene; Petrizzo, Maria Rose; Falzoni, Francesca; Littler, Kate; Arz, José Antonio; Russell, Ernest E

    2014-06-17

    The Late Cretaceous 'greenhouse' world witnessed a transition from one of the warmest climates of the past 140 million years to cooler conditions, yet still without significant continental ice. Low-latitude sea surface temperature (SST) records are a vital piece of evidence required to unravel the cause of Late Cretaceous cooling, but high-quality data remain illusive. Here, using an organic geochemical palaeothermometer (TEX86), we present a record of SSTs for the Campanian-Maastrichtian interval (~83-66 Ma) from hemipelagic sediments deposited on the western North Atlantic shelf. Our record reveals that the North Atlantic at 35 °N was relatively warm in the earliest Campanian, with maximum SSTs of ~35 °C, but experienced significant cooling (~7 °C) after this to cooling pattern was global rather than regional and, therefore, driven predominantly by declining atmospheric pCO2 levels.

  4. Friedman-Robertson-Walker Models with Late-Time Acceleration

    Institute of Scientific and Technical Information of China (English)

    Abdussattar; S. R. Prajapati2

    2011-01-01

    @@ In order to account for the observed cosmic acceleration, a modiGcation of the ansatz for the variation of density in Friedman-Robertson-Walker (FRW) FRW models given by Islam is proposed.The modified ansatz leads to an equation of state which corresponds to that of a variable Chaplygin gas, which in the course of evolution reduces to that of a modified generalized Chaplygin gas (MGCG) and a Chaplygin gas (CG), exhibiting late-time acceleration.%In order to account for the observed cosmic acceleration, a modification of the ansatz for the variation of density in Friedman-Robertson-Walker (FRW) FRW models given by Islam is proposed. The modified ansatz leads to an equation of state which corresponds to that of a variable Chaplygin gas, which in the course of evolution reduces to that ora modified generalized Chaplygin gas (MGCG) and a Chaplygin gas (CG), exhibiting late-time acceleration.

  5. The late Cretaceous Arman flora of Magadan oblast, Northeastern Russia

    Science.gov (United States)

    Herman, A. B.; Golovneva, L. B.; Shczepetov, S. V.; Grabovsky, A. A.

    2016-12-01

    The Arman flora from the volcanogenic-sedimentary beds of the Arman Formation is systematically studied using materials from the Arman River basin and the Nelkandya-Khasyn interfluve (Magadan oblast, Northeastern Russia). Seventy-three species of fossil plants belonging to 49 genera are described. They consist of liverworts, horsetails, ferns, seed ferns, cycadaleans, bennettitaleans, ginkgoaleans, czekanowskialeans, conifers, gymnosperms of uncertain systematic affinity, and angiosperms. The Arman flora shows a unique combination, with relatively ancient Early Cretaceous ferns and gymnosperms occurring alongside younger Late Cretaceous plants, primarily angiosperms. The similarity of the Arman flora to the Penzhina and Kaivayam floras of northwestern Kamchatka and the Tylpegyrgynai flora of the Pekul'nei Ridge allows the Arman flora to be dated as Turonian and Coniacian (Late Cretaceous), which is corroborated by isotopic (U-Pb and 40Ar/39Ar) age determination for the plant-bearing layers.

  6. North American nonmarine climates and vegetation during the Late Cretaceous

    Science.gov (United States)

    Wolfe, J.A.; Upchurch, G.R.

    1987-01-01

    Analyses of physiognomy of Late Cretaceous leaf assemblages and of structural adaptations of Late Cretaceous dicotyledonous woods indicate that megathermal vegetation was an open-canopy, broad-leaved evergreen woodland that existed under low to moderate amounts of rainfall evenly distributed through the year, with a moderate increase at about 40-45??N. Many dicotyledons were probably large, massive trees, but the tallest trees were evergreen conifers. Megathermal climate extended up to paleolatitude 45-50??N. Mesothermal vegetation was at least partially an open, broad-leaved evergreen woodland (perhaps a mosaic of woodland and forest), but the evapotranspirational stress was less than in megathermal climate. Some dicotyledons were large trees, but most were shrubs or small trees; evergreen conifers were the major tree element. Some mild seasonality is evidenced in mesothermal woods; precipitational levels probably varied markedly from year to year. Northward of approximately paleolatitude 65??N, evergreen vegetation was replaced by predominantly deciduous vegetation. This replacement is presumably related primarily to seasonality of light. The southern part of the deciduous vegetation probably existed under mesothermal climate. Comparisons to leaf and wood assemblages from other continents are generally consistent with the vegetational-climatic patterns suggested from North American data. Limited data from equatorial regions suggest low rainfall. Late Cretaceous climates, except probably those of the Cenomanian, had only moderate change through time. Temperatures generally appear to have warmed into the Santonian, cooled slightly into the Campanian and more markedly into the Maastrichtian, and then returned to Santonian values by the late Maastrichtian. The early Eocene was probably warmer than any period of the Late Cretaceous. Latitudinal temperature gradients were lower than at present. For the Campanian and Maastrichtian, a gradient of about 0.3??C/1

  7. Separation-individuation and assertiveness in late adolescents

    Directory of Open Access Journals (Sweden)

    Aslan, Sevda

    2013-07-01

    Full Text Available An adolescent can experience some problems regarding assertiveness during the course of separation-individuation from their caregivers. The purpose of this study is to describe the relationship between separation-individuation and assertiveness, which was examined in terms of how assertiveness predicts the separation-individuation of Turkish late adolescents. The sampling group consisted of 283 university students. The data gathered were analyzed by involving several simple regression analysis method. The findings revealed that aassertiveness predicts separation anxiety in a meaningful way. Furthermore, the assertiveness predicts engulfment anxiety, peer enmeshment, need denial, practicing-mirroring, rejection expectancy, and healthy separation. These findings suggest that psycho-educational studies improving assertiveness can be carried out for the late adolescents who experience separation-individuation problems.

  8. Late time CMB anisotropies constrain mini-charged particles

    Energy Technology Data Exchange (ETDEWEB)

    Burrage, C.; Redondo, J.; Ringwald, A. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Jaeckel, J. [Univ. of Durham, Inst. for Particle Physics Phenomenology (United Kingdom)

    2009-09-15

    Observations of the temperature anisotropies induced as light from the CMB passes through large scale structures in the late universe are a sensitive probe of the interactions of photons in such environments. In extensions of the Standard Model which give rise to mini-charged particles, photons propagating through transverse magnetic fields can be lost to pair production of such particles. Such a decrement in the photon flux would occur as photons from the CMB traverse the magnetic fields of galaxy clusters. Therefore late time CMB anisotropies can be used to constrain the properties of mini- charged particles. We outline how this test is constructed, and present new constraints on mini-charged particles from observations of the Sunyaev-Zel'dovich effect in the Coma cluster. (orig.)

  9. The virtues of balm in late medieval literature.

    Science.gov (United States)

    Truitt, Elly R

    2009-01-01

    This article argues that balm, or balsam, was, by the late medieval period, believed to be a panacea, capable of healing wounds and illnesses, and also preventing putrefaction. Natural history and pharmacological texts on balm from the ancient and late antique periods emphasized specific qualities of balm, especially its heat; these were condensed and repeated in medieval encyclopedias. The rarity and cost of balsam, from antiquity through the medieval period, and the high rate of counterfeiting also demonstrate its high demand and significance in medicine and religious ritual. Travel writing and itineraria from the early and central medieval periods added a new layer to ideas about the capabilities of balsam: that it originated from a Christian miracle and was a particularly Christian plant.

  10. Late Eocene impact microspherules - Stratigraphy, age and geochemistry

    Science.gov (United States)

    Keller, G.; D'Hondt, S. L.; Orth, C. J.; Gilmore, J. S.; Oliver, P. Q.; Shoemaker, E. M.; Molina, E.

    1987-03-01

    The stratigraphy, faunal changes, and geochemistry of deep-sea sediments associated with late Eocene microtektite and microspherule layers are reported. Microprobe analyses of major element compositions of microspherules show that, although there is some compositional overlap in all three late Eocene layers as well as with the Pleistocene Australasian and Ivory Coast microtektites, each microspherule population has characteristic compositional features. All three microspherule layers are associated with decreased carbonate, possibly due to a sudden productivity change, increased dissolution as a result of sea-level and climate fluctuations, or impact events. A discovery of microtektites in the Gl. cerroazulensis Zone off the New Jersey coast extends the North American strewn field from the Caribbean to the northwest Atlantic.

  11. Late lessons from early warnings: science, precaution, innovation

    DEFF Research Database (Denmark)

    Hansen, Steffen Foss

    2013-01-01

    rather than present specific estimates for these costs. Making the best use of environmental science and modelling helps to make environmental protection and precaution a priority. Producing cost estimates should not be left to economists alone, but should rather be seen as a starting point for a broader...... innovations whilst minimising harms. This chapter revisits some key environmental issues for which estimates of costs of inaction have been carefully developed over many years of research. The aim is to consider the methodological challenges involved in producing estimates that are credible and appropriate......The 2013 Late lessons from early warnings report is the second of its type produced by the European Environment Agency (EEA) in collaboration with a broad range of external authors and peer reviewers. The case studies across both volumes of Late lessons from early warnings cover a diverse range...

  12. Auto industry late followers knowledge creation through internationalization

    Directory of Open Access Journals (Sweden)

    Marković Dušan

    2016-01-01

    Full Text Available Radical changes of business environment have been caused by growing globalization at the beginning of the 21st century. Consequently, a strong network of trade and investment relationships between national economies has been established. Although it entails many risks, global business environment opens up great opportunities, as well. In order to seize these opportunities, many companies from emerging markets internationalize their business operations, and thus challenge once untouchable leaders from developed countries. Traditional theories on multinational companies cannot fully explain their motives for going abroad. Recently, the automotive industry has become a new field where the late followers from emerging markets try to challenge the leaders. This paper includes the following three case studies: Hyundai - Kia, Geely - Volvo, and Tata Motors - Jaguar Land Rover. These case studies show that although the late followers in the automotive industry use different internationalization strategies, they all perceive internationalization as a means of obtaining the lacking competencies and building up a positive reputation.

  13. Environmental Effects on Late-Type Galaxies in Nearby Clusters

    CERN Document Server

    Boselli, A

    2006-01-01

    The transformations taking place in late-type galaxies in the environment of rich clusters of galaxies at z=0 are reviewed. From the handful of late-type galaxies that inhabit local clusters, whether they were formed in-situ and survived as such, avoiding transformation or even destruction or if they are newcomers that recently infall from outside, we can learn an important lesson on the latest stages of galaxy evolution. We start by reviewing the observational scenario, covering the broadest possible stretch of the electromagnetic spectrum, from the gas tracers, the star formation tracers, the old star tracers and the dust. Strong emphasis is given to the three nearby, well studied clusters Virgo, A1367 and Coma, representative of different evolutionary stages, from unrelaxed, spiral rich (Virgo) to relaxed, spiral poor clusters (Coma). We continue by providing a review of models of galaxy interactions relevant to clusters of galaxies. Prototypes of various mechanisms and processes are discussed and their ty...

  14. Late Relapses in Stage I Testicular Cancer Patients on Surveillance

    DEFF Research Database (Denmark)

    Mortensen, Mette Saksø; Lauritsen, Jakob; Kier, Maria Gry Gundgaard

    2016-01-01

    BACKGROUND: Comprehensive data on late relapse (LR) and very LR (VLR) in patients with clinical stage I (CS-1) testicular cancer followed on surveillance are missing. These data are essential for planning optimal follow-up. OBJECTIVE: Assess incidence and outcome of LR (>2 yr) and VLR (>5 yr...... patients with LR(VLR) do not differ significantly from patients with ER. PATIENT SUMMARY: We compared stage I testicular cancer surveillance patients with early relapse (ER) versus late relapse (LR; >2 yr). LR patients as a group did no worse than ER patients, although increased time to relapse......) in a large cohort of CS-1 surveillance patients, and examine differences in the clinical characteristics of patients with early relapse (ER), LR, and VLR. DESIGN, SETTING, AND PARTICIPANTS: CS-1 surveillance patients diagnosed between 1984 and 2007 were identified from the retrospective Danish Testicular...

  15. Late Silurian trilete spores from northern Jiangsu, China.

    Science.gov (United States)

    Wang; Li

    2000-08-01

    The Late Silurian is generally considered to a particular significant key period in the study of early land vascular plants. A trilete spore assemblage of the Upper Silurian is described from northern Jiangsu, China. This assemblage comprises 11 genera and 20 species of trilete spores (including laevigate, apiculate, perinotrilite, patinate, rarely distally murornate and equatorially crassitate, and three indeterminate trilete miospores forms). It has similarities to those described from coeval assemblages from around the world (e.g., England and South Wales; Tripolitania, Libya; Cornwallis Island, Canadian Arctic; Northwest Spain). The rare cryptospore, only one specimen (Tetrahedraletes sp.) had been found to be associated with the Chinese trilete spore assemblage. The discovery of the trilete spores from Late Silurian rocks indicates the existence of early land plants, some possibly vascular, at that time in northern Jiangsu, China.

  16. RB975242 and RB975201 - Late maturation sugarcane varieties

    Directory of Open Access Journals (Sweden)

    Monalisa Sampaio Carneiro

    2016-11-01

    Full Text Available The sugarcane varieties RB975201 and RB975242 were developed and released for harvest at the end of the season (late maturation in the CentralSouth region of Brazil. In specific environments, these varieties were compared with commercial standards in sugar yield per area. They are resistant to major sugarcane diseases and present the Bru1 gene of resistance to brown rust.

  17. Cardiomyopathy: a late complication of hemolytic uremic syndrome.

    Science.gov (United States)

    Walker, A M; Benson, L N; Wilson, G J; Arbus, G S

    1997-04-01

    This report describes a child who presented with classic hemolytic uremic syndrome (HUS) and 4 months later developed a life-threatening but reversible cardiomyopathy with global cardiac dysfunction and a left ventricular ejection fraction of 14%. There was no evidence of electrolyte abnormalities, anemia, hypertension, severe fluid overload, or viral infection. Endomyocardial biopsies were consistent with a dilated cardiomyopathy. This paper highlights the importance of considering the diagnosis of associated cardiomyopathy when presenting with late-onset edema following HUS.

  18. Hot Dust! Late-Time Infrared Emission From Supernovae

    Science.gov (United States)

    Fox, Ori; Skrutskie, M. F.; Chevalier, R. A.

    2010-01-01

    Supernovae light curves typically peak and fade in the course of several months. Some supernovae , however, exhibit late-time infrared emission that in some cases can last for several years. These supernovae tend to be of the Type IIn subclass, which is defined by narrow hydrogen and helium emission lines arising from a dense, pre-existing circumstellar medium excited by the supernova radiation. Such a late-time ``IR excess'' with respect to the optical blackbody counterpart typically indicates the presence of warm dust. The origin and heating mechanism of the dust is not, however, always well constrained. In this talk, I will explore several scenarios that explain the observed late-time emission. In particular, I will discuss the case of the Type IIn SN 2005ip, which has displayed an ``IR excess'' for over 3 years. The results allow us to interpret the progenitor system and better understand the late stages of stellar evolution. Much of the data used for this analysis were obtained with TripleSpec, a medium-resolution near-infrared spectrograph located at Apache Point Observatory, NM, and FanCam, a JHK imager located at Fan Mountain Observatory, just outside of Charlottesville, VA. These two instruments were designed, fabricated, built, and commissioned by our instrumentation group at the University of Virginia. I will also spend some time discussing these instruments. I would like to thank the following for financial support of this work throughout my graduate career: NASA GSRP, NSF AAG-0607737, Spitzer PID 50256, Achievement Reward for College Scientists (ARCS), and the Virginia Space Grant Consortium.

  19. School mobility during childhood predicts psychotic symptoms in late adolescence

    OpenAIRE

    Winsper, Catherine; Wolke, Dieter; Bryson, Alex; Thompson, Andrew D.; Singh, Swaran P.

    2016-01-01

    Background: Recently, school mobility was identified as a risk factor for psychotic symptoms in early adolescence. The extent to which this risk continues into late adolescence, and the trajectories via which this risk manifests, remain unexplored.\\ud \\ud Methods: Psychotic symptoms in 4, 720 adolescents aged 18 were ascertained by trained psychologists using the Psychosis-Like Symptoms Interview. Mothers reported on sociodemographic factors (i.e., family adversity, ethnicity, urbanicity) fro...

  20. Dementia with impaired glucose metabolism in late onset metachromatic leukodystrophy

    DEFF Research Database (Denmark)

    Johannsen, P.; Ehlers, L.; Hansen, Hans Jacob

    2001-01-01

    An unusual case of very-late-onset metachromatic leukodystrophy (MLD) with dementia was studied. The patient was a 41-year-old male who presented with mild dementia and a single generalized tonic clonic seizure. Neuropsychological assessment demonstrated mild amnesia, visuospatial dysfunction and...... was observed using positron emission tomography and fluor-18-labeled fluorodesoxyglucose. The neuropsychological deficits are related to the location of deficits in glucose metabolism....

  1. Late Quaternary record of pteropod preservation from the Andaman Sea

    Digital Repository Service at National Institute of Oceanography (India)

    Sijinkumar, A.V.; Nath, B.N.; Guptha, M.V.S.

    . Millennial/centennial-scale thermocline ventilation changes in the Indian Ocean as reflected by aragonite preservation and geochemical variations in Arabian Sea sediments. Geochimica et Cosmochimica Acta 73, 6771–6788. Brown, B.E., 2007. Coral reefs... Quaternary millennial-scale variability in pelagic aragonite preservation off Somalia. Marine Micropaleontology 59, 171- 183. Klöcker, R., Henrich, R., 2006. Recent and Late Quaternary pteropod preservation on the Pakistan shelf and continental slope...

  2. Late Cretaceous Aquatic Angiosperms from Jiayin, Heilongjiang,Northeast China

    Institute of Scientific and Technical Information of China (English)

    QUAN Cheng; SUN Ge

    2008-01-01

    Three taxa of Late Cretaceous aquatic angiosperms, Queruexia angulata (Lesq.) Krysht., Cobbania corrugate. (Lesq.) Stockey et al. and Nelumbites cf. extenuinervis Upchurch et al. from Jiayin of Heilongjiang, NE China, are described in detail. Among them, Cobbania and Nelumbites from the Upper Cretaceous in China are reported for the first time. The aquatic angiosperm assemblage of Queruexia-Cobbania-Nelumbites appears to imply a seasonal, warm and moist environment in the Jiayin area during the Santonian-Campanian time.

  3. New Wine in Old Bottle: Late-Life Psychosis

    Science.gov (United States)

    Iglewicz, Alana; Meeks, Thomas W.; Jeste, Dilip V.

    2011-01-01

    Psychosis is common in late life and exacts enormous costs to society, affected individuals, and their caregivers. A multitude of etiologies for late-life psychosis exist, the two most prototypical being schizophrenia and psychosis of Alzheimer’s Disease (AD). As such, this review will focus on the non-affective, neuropsychiatric causes of chronic psychosis in the elderly, specifically schizophrenia, delusional disorder, and the psychosis of AD and other dementias. As evidenced in this review, the current research regarding the onset and course of late-life schizophrenia reflects a more favorable prognosis than that painted by the Kraepelinian notion of schizoprenia as “dementia praecox.” Antipsychotics are useful in controlling the symptoms of late-life schizophrenia, but their use among older adults warrants increased vigilance because of older adults’ increased proclivity to side effects. Psychosocial interventions can be effective, usually in conjunction with medication. Meanwhile, psychosis of AD occurs in nearly half of people with AD and is associated with increased hospitalizations, institutionalization, caregiver distress, and mortality. Despite the profound consequences of psychotic symptoms associated with dementias, the extant literature does not afford clinicians clear, consistent guidance on how to provide optimal treatment to specific patients. Second generation antipsychotics are usually the choice treatment for psychosis, but the black box warning regarding their associated 1–2% increased absolute risk in stroke and overall mortality in patients with dementia complicates their use. Using second generation antipsychotics in low doses for brief periods and discontinuing them when possible is the best clinical practice for dementia-related psychosis. Psychosocial interventions for the treatment of psychosis with AD appear promising in empirical research, but more rigorous study is needed. PMID:21536160

  4. [Edge effect and late thrombosis -- inevitable complications of vascular brachytherapy?].

    Science.gov (United States)

    Schiele, T M; Staber, L; Kantlehner, R; Pöllinger, B; Dühmke, E; Theisen, K; Klauss, V

    2002-11-01

    Restenosis is the limiting entity after percutaneous coronary angioplasty. Vascular brachytherapy for the treatment of in-stent restenosis has been shown to reduce the repeat restenosis rate and the incidence of major adverse events in several randomized trials. Besides the beneficial effects, brachytherapy yielded some unwanted side effects. The development of new stenoses at the edges of the target lesion treated with radiation is termed edge effect. It occurs after afterloading brachytherapy as well as after implantation of radioactive stents. It is characterized by extensive intimal hyperplasia and negative remodeling. As contributing factors the axial dose fall-off, inherent to all radioactive sources, and the application of vessel wall trauma by angioplasty have been identified. The combination of both factors, by insufficient overlap of the radiation length over the injured vessel segment, has been referred to as geographic miss. It has been shown to be associated with a very high incidence of the edge effect. Avoidance of geographic miss is strongly recommended in vascular brachytherapy procedures. Late thrombosis after vascular brachytherapy is of multifactorial origin. It comprises platelet recruitment, fibrin deposition, disturbed vasomotion, non-healing dissection and stent malapposition predisposing to turbulent blood flow. The strongest predictors for late thrombosis are premature discontinuation of antiplatelet therapy and implantation of new stents during the brachytherapy procedure. With a consequent and prolonged antiplatelet therapy, the incidence of late thrombosis has been reduced to placebo levels. Edge effect and late thrombosis represent unwanted side effects of vascular brachytherapy. By means of a thorough treatment planning and prolonged antiplatelet therapy their incidences can be largely reduced. With regard to the very favorable net effect, they do not constitute relevant limitations of vascular brachytherapy.

  5. OPHTHALMIC FINDINGS IN LATE STAGE SJOGREN-LARSSON SYNDROME.

    Science.gov (United States)

    Nanda, Tavish; Kovach, Jaclyn L

    2017-03-15

    To report spectral domain optical coherence tomography and fundus autofluorescence documentation of late stage macular findings associated with Sjogren-Larsson Syndrome in three adult siblings. Three adult siblings with Sjogren-Larsson Syndrome underwent ophthalmic examination and imaging. Crystalline maculopathy and subretinal deposits, presumably lipofuscin accumulation, with macular atrophy were present in varying degrees in all three adult siblings. In adults with Sjogren-Larsson Syndrome, crystalline retinopathy can progress to macular atrophy and the appearance of lipofuscin accumulation.

  6. MYOCLONIC EPILEPSY OF LATE-ONSET IN TRISOMY-21

    OpenAIRE

    L. M. Li; ODONOGHUE, N. F.; Sander, JWAS

    1995-01-01

    We report the case of a patient with trisomy 21 (T21) with late onset epilepsy. The electroclinical features were of myoclonic jerks on awakening and generalised tonic clonic seizures, with generalised spike and wave on EEG, and a progressive dementia. As familial Alzheimer's dementia and progressive myoclonic epilepsy (Unverricht-Lundborg type) are both linked to the chromosome 21, this case may represent a distinct progressive myoclonic epilepsy related to T21.

  7. Anoxia in the terrestrial environment during the late Mesoproterozoic.

    OpenAIRE

    2013-01-01

    A significant body of evidence suggests that the marine environment remained largely anoxic throughout most of the Precambrian. In contrast, the oxygenation history of terrestrial aquatic environments has received little attention, despite the significance of such settings for early eukaryote evolution. To address this, we provide here a geochemical and isotopic assessment of sediments from the late Mesoproterozoic Nonesuch Formation of central North America. We utilize rhenium-osmium (Re-Os)...

  8. Late Onset Combined Immunodeficiency Presenting with Recurrent Pneumocystis jiroveci Pneumonia

    OpenAIRE

    Ilias Papakonstantinou; Ioannis G. Baraboutis; Lazaros Karnesis

    2014-01-01

    Late onset combined immunodeficiency (LOCID) is a recently described variant of common variable immunodeficiency (CVID), involving adult patients presenting with opportunistic infections and/or low CD4+ lymphocyte counts. A 36-year-old male with unremarkable past medical history presented with fever, respiratory failure, and lymphocytopenia. He was found to have Pneumocystis jiroveci pneumonia (PJP), subsequently complicated by recurrent hospital-acquired Pseudomonas aeruginosa pneumonia and ...

  9. Friedman—Robertson—Walker Models with Late-Time Acceleration

    Science.gov (United States)

    Abdussattar; Prajapati, S. R.

    2011-02-01

    In order to account for the observed cosmic acceleration, a modification of the ansatz for the variation of density in Friedman—Robertson—Walker (FRW) FRW models given by Islam is proposed. The modified ansatz leads to an equation of state which corresponds to that of a variable Chaplygin gas, which in the course of evolution reduces to that of a modified generalized Chaplygin gas (MGCG) and a Chaplygin gas (CG), exhibiting late-time acceleration.

  10. [Late tamponade after heart surgery: a dreadful diagnostic pitfall].

    Science.gov (United States)

    Glock, Y F; Herreros, J; Tejeira, F J

    1983-05-01

    In a series of 250 consecutive open-heart operations, three cases of late cardiac tamponade were noted following the operation. This led the authors to review the literature pertaining to this complication. Ninety-nine cases were collected. The frequency of late tamponade associated with cardiac surgery was 0.62% and was fatal in 16.2% of those cases. The delay before the tamponade appeared varied from 3 days to 3 months (mean 14.5 +/- 7.8 days). The initial clinical picture is insidious and vague, and this constitutes the danger of late cardiac tamponade. The clinical signs are of the respiratory (dyspnea, chest pain), gastrointestinal (anorexia, vomiting) and central nervous (mental confusion, even coma) systems. Pallor with a drop in hematocrit in patients on anticoagulant therapy suggests occult bleeding. A definitive diagnosis depends on catheterization of the right side and on mono- and bidimensional echocardiography. The authors believe that computerized axial tomography represents an interesting noninvasive and reliable examination technique when it can be used during emergency treatment. Pericardial puncture, which is both a diagnostic and therapeutic technique, was useful in one third of the cases; it produced a false-negative result in 12%. The resulting differential diagnoses are pulmonary embolism, myocardial insufficiency and septic shock. Late cardiac tamponade may be produced by one of two mechanisms: hemopericardium due to overdosage of anticoagulants or an exacerbated form of the post-pericardiotomy syndrome. Emergency treatment is always necessary. Pericardiocentesis is a useful diagnostic aid and provides temporary stabilization preoperatively. A wide surgical approach is always indicated. The mortality in untreated patients is 100%. The frequency of immediate relapse or, occasionally, of delayed relapse is estimated to be 11%; relapse may be lethal.

  11. Thematizing the Subject from Gothicism to Late Romanticism

    OpenAIRE

    Sucur, Slobodan

    2000-01-01

    In "Thematizing the Subject from Gothicism to Late Romanticism," Slobodan Sucur takes Habermas's suggestion that "modern art reveals its essence in Romanticism; and absolute inwardness determines the form and content of Romantic art" and offers an analysis of a spectrum of primary texts in relation to the statement. The texts analysed range from Walpole’s The Castle of Otranto to Odoyevsky’s Russian Nights. The texts are analyzed in chronological fashion, in an attempt to see how the thematiz...

  12. Separation-individuation and assertiveness in late adolescents

    OpenAIRE

    ASLAN, Sevda

    2013-01-01

    An adolescent can experience some problems regarding assertiveness during the course of separation-individuation from their caregivers. The purpose of this study is to describe the relationship between separation-individuation and assertiveness, which was examined in terms of how assertiveness predicts the separation-individuation of Turkish late adolescents. The sampling group consisted of 283 university students. The data gathered were analyzed by involving several simple regression analysi...

  13. Friedmann-Robertson-Walker Models with Late-Time Acceleration

    CERN Document Server

    Abdussattar,

    2016-01-01

    In order to account for the observed cosmic acceleration, a modification of the ansatz for the variation of density in Friedman-Robertson-Walker (FRW) models given by Islam is proposed. The modified ansatz leads to an equation of state which corresponds to that of a variable Chaplygin gas, which in the course of evolution reduces to that of a modified generalized Chaplygin gas (MGCG) and a Chaplygin gas (CG), exhibiting late-time acceleration.

  14. Late-onset Bochdalek's Hernia Associated with Severe Dyspnea

    OpenAIRE

    早川, 峰司; 丸藤, 哲; 森本, 裕二; 武山, 佳洋; 中村, 宏治; 古根, 高; 松原, 泉

    2001-01-01

    Late-onset Bochdalek's hernia is rare enough to be frequently diagnosed incorrectly. We present a case of lateonset Bochdalek's hernia associated with severe dyspnea and cyanosis. A 14-month-old female infant was admitted to our emergency clinic due to severe dyspnea and cyanosis. A chest radiogram and computed tomographic (CT) scan revealed a gastrointestinal shadow in the left thorax, necessitating emergency surgery that confirmed Bochdalek's hernia. Although left lung dysplasia was observe...

  15. Adherence to discharge guidelines for late-preterm newborns.

    Science.gov (United States)

    Goyal, Neera K; Fager, Corinne; Lorch, Scott A

    2011-07-01

    To evaluate trends in adherence to American Academy of Pediatrics recommendations for early discharge of late-preterm newborns and to test the association between hospital characteristics and early discharge. This study was a population-based cohort study using statewide birth-certificate and hospital-discharge data for newborns in California, Missouri, and Pennsylvania from 1993 to 2005. A total of 282 601 late-preterm newborns at 611 hospitals were included. Using logistic regression, we studied the association of early discharge with regional and hospital factors, including teaching affiliation, volume, and urban versus rural location, adjusting for patient factors. From 1995 to 2000, early discharge decreased from 71% of the sample to 40%. However, by 2005, 39% were still discharged early. Compared with Pennsylvania, California (adjusted odds ratio [aOR]: 5.95 [95% confidence interval (CI): 5.03-7.04]), and Missouri (aOR: 1.56 [95% CI: 1.26-1.93]) were associated with increased early discharge. Nonteaching hospitals were more likely than teaching hospitals to discharge patients early if they were uninsured (aOR: 1.91 [95% CI: 1.35-2.69]) or in a health maintenance organization plan (aOR: 1.40 [95% CI: 1.06-1.84]) but not patients with fee-for-service insurance (aOR: 1.04 [95% CI: 0.80-1.34]). A similar trend for newborns on Medicaid was not statistically significant (aOR: 1.77 [95% CI: 0.95-3.30]). Despite a decline in the late 1990s, early discharge of late-preterm newborns remains common. We observe differences according to state, hospital teaching affiliation, and patient insurance. Additional research on the safety and appropriateness of early discharge for this population is necessary. Copyright © 2011 by the American Academy of Pediatrics.

  16. Late reconstruction of condylar neck and head fractures.

    Science.gov (United States)

    Davis, Ben

    2013-11-01

    Condyle fractures are a common injury, but only a few of these injuries require immediate or late reconstruction. The complications that most frequently necessitate condylar reconstruction include proximal segment degeneration, malunion, and ankylosis. Costochondral grafts and total joint prostheses, both stock and custom, remain the most common methods of reconstruction. Reconstruction plates with condylar extensions should only be used temporarily as an unacceptable number cause serious complications. Distraction osteogenesis may have an occasional role in reconstructing the posttraumatic condyle.

  17. Analysis of electric vehicle's trip cost without late arrival

    Science.gov (United States)

    Leng, Jun-Qiang; Zhao, Lin

    2017-03-01

    In this paper, we use a car-following model to study each electric vehicle's trip cost and the corresponding total trip cost without late arrival. The numerical result show that the electricity cost has significant effects on each electric vehicle's trip cost and the corresponding total trip costs and that the effects are dependent on its time headway at the origin, but the electricity cost has no prominent effects on the minimum value of the system's total trip cost.

  18. Functioning in early and late stages of schizophrenia

    Directory of Open Access Journals (Sweden)

    Leonardo Gazzi Costa

    2014-12-01

    Full Text Available INTRODUCTION: Schizophrenia is frequently associated with a debilitating course and prominent impairment in social and occupational functioning. Although the criteria for classification into stages have not been defined in the literature, illness duration and functioning seem to be good candidates.OBJECTIVE:To compare functioning of patients with schizophrenia at different stages of the disease (early vs. late and healthy sex- and age-matched controls.METHODS: This double-blinded, case-controlled study included 79 individuals: 23 patients with schizophrenia diagnosed up to 5 years earlier; 19 patients with schizophrenia diagnosed at least 20 years earlier; and healthy matched controls. Diagnoses were established using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV Axis I Disorder. Functioning was assessed using the Functioning Assessment Short Test (FAST.RESULTS: Patients in the early stage had significantly higher scores than healthy controls in total FAST and in autonomy, occupational functioning, cognitive functioning and interpersonal relationships. Individuals in the late stage had significantly poorer functioning than controls in all domains. The comparison of functioning between the two groups of patients revealed no significant differences, except in occupational functioning, in which late stage patients had a poorer performance.CONCLUSION: Functioning impairment in schizophrenia tends to remain stable despite illness duration. Therefore, functioning should be effectively assessed at an early stage, as illness duration alone may not be the most reliable criterion to stage patients with schizophrenia.

  19. Hypertriglyceridemia and unusual lipoprotein subclass distributions associated with late pregnancy

    Energy Technology Data Exchange (ETDEWEB)

    Forte, T.M.; Kretchmer, N.; Silliman, K. (Lawrence Berkeley Lab., CA (United States))

    1991-03-15

    In the human adult population elevated plasma triglyceride (TG) levels are associated with decreased high density lipoprotein-cholesterol (HDL-C) levels and decreased HDL and LDL particle sizes. Late pregnancy is a hypertriglyceridemic state where little is known about LDL and HDL subpopulation distribution. Plasma lipids, apolipoproteins (apo) and lipoprotein subpopulations were examined in 36 pregnant women at 36 wk pregnancy and 6 wk postpartum and correlated with HDL and LDL size. There was a significant decrease in LDL diameter at 36 wk pre, 25 {plus minus} 0.7 nm compared, with 6 wk post, 26.4 {plus minus} 0.8 nm. A total of 97% of the 36 wk pre subjects had small dense LDL which paralleled increases in apoB concentration. Unlike LDL HDL at 36 wks pre showed a significant increase in larger sized particles where HDL{sub 2b} predominated. There was a positive correlation between HDL{sub 2b} mass and apoAl and HDL-C concentrations. Late pregnancy is a metabolic state where the predominance of large, HDL{sub 2b} particles is discordant with the predominance of small LDL and elevated TG. This annual metabolic pattern may in part be due to hormonal changes occurring in late pregnancy.

  20. Thecamoebians from Late Permian Gondwana sediments of peninsular India.

    Science.gov (United States)

    Farooqui, Anjum; Aggarwal, Neha; Jha, Neerja

    2014-02-01

    The evolutionary history of thecamoebians (testate amoebae) extends back to the Neoproterozoic Era. However, until now, these have had a restricted, discontinuous and modest record across the world. The studied sediment of Raniganj Formation (Godavari Graben), Andhra Pradesh, India has been assigned as Late Permian on the basis of co-occurring age-diagnostic Late Permian palynomorphs. About sixteen thecamoebian species and one taxon incertae sedis have been recorded here in the palynological slides on the basis of shell morphology and morphometry. Out of these, five belong to the family Arcellidae, seven to Centropyxidae, two to Trigonopyxidae, one to Difflugiidae, one to Plagiopyxidae, and one is regarded incertae sedis. The morphometric characteristics of fossil forms resemble their corresponding extant species studied from ecologically diverse fresh water wetlands in India. In general, the ratio of shell diameter and aperture diameter of Late Permian fossil and extant specimens show significant correlation in all the studied species. Except that, the ratio of shell length and breadth is the distinguishing feature between Centropyxis aerophila and C. aerophila 'sylvatica', rather than the ratio of shell length and longest diameter of the shell aperture in both fossil and extant forms. The study elucidates the minimal morphological evolution in thecamoebians and their survival during mass extinction periods and stressful environmental conditions over the geological timescale.

  1. Comorbidities and the Risk of Late-Stage Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Steven T. Fleming

    2006-01-01

    Full Text Available The degree to which comorbidities affect the diagnosis of prostate cancer is not clear. The purpose of this study was to determine how comorbidities affect the stage at which prostate cancer is diagnosed in elderly white and black men. We obtained data from the Surveillance, Epidemiology, and End Results program of the National Cancer Institute merged with Medicare claims data. For each patient, we estimated associations between stage of disease at diagnosis and each of the 27 comorbidities. The sample included 2,489 black and 2,587 white men with staged prostate cancer. Coronary artery disease, benign hypertension, and dyslipidemia reduced the odds of late-stage prostate cancer. A prior diagnosis of peripheral vascular disease, severe renal disease, or substance abuse increased the odds of being diagnosed with late-stage disease. The study shows some effect modification by race, particularly among white men with substance abuse, cardiac conduction disorders, and other neurologic conditions. The strongest predictors of late-stage prostate cancer diagnosis for both white and black men were age at diagnosis of at least 80 years and lack of PSA screening. Comorbidities do affect stage at diagnosis, although in different ways. Four hypotheses are discussed to explain these findings.

  2. Identifying and Investigating the Late-1960s Interhemispheric SST Shift

    Science.gov (United States)

    Friedman, A. R.; Lee, S. Y.; Liu, Y.; Chiang, J. C. H.

    2014-12-01

    The global north-south interhemispheric sea surface temperature (SST) difference experienced a pronounced and rapid decrease in the late 1960s, which has been linked to drying in the Sahel, South Asia, and East Asia. However, some basic questions about the interhemispheric SST shift remain unresolved, including its scale and whether the constituent changes in different basins were coordinated. In this study, we systematically investigate the spatial and temporal behavior of the late-1960s interhemispheric SST shift using ocean surface and subsurface observations. We also evaluate potential mechanisms using control and specific-forcing CMIP5 simulations. Using a regime shift detection technique, we identify the late-1960s shift as the most prominent in the historical observational SST record. We additionally examine the corresponding changes in upper-ocean heat content and salinity associated with the shift. We find that there were coordinated upper-ocean cooling and freshening in the subpolar North Atlantic, the region of the largest-magnitude SST decrease during the interhemispheric shift. These upper-ocean changes correspond to a weakened North Atlantic thermohaline circulation (THC). However, the THC decrease does not fully account for the rapid global interhemispheric SST shift, particularly the warming in the extratropical Southern Hemisphere.

  3. Where Is ELSA? The Early to Late Shift in Aging

    Science.gov (United States)

    Buchler, Norbou; Dobbins, Ian G.; Cabeza, Roberto

    2012-01-01

    Studies of cognitive and neural aging have recently provided evidence of a shift from an early- to late-onset cognitive control strategy, linked with temporally extended activity in the prefrontal cortex (PFC). It has been uncertain, however, whether this age-related shift is unique to PFC and executive control tasks or whether the functional location might vary depending on the particular cognitive processes that are altered. The present study tested whether an early-to-late shift in aging (ELSA) might emerge in the medial temporal lobes (MTL) during a protracted context memory task comprising both anticipatory cue (retrieval preparation) and retrieval probe (retrieval completion) phases. First, we found reduced MTL activity in older adults during the early retrieval preparation phase coupled with increased MTL activity during the late retrieval completion phase. Second, we found that functional connectivity between MTL and PFC regions was higher during retrieval preparation in young adults but higher during retrieval completion in older adults, suggesting an important interactive relationship between the ELSA pattern in MTL and PFC. Taken together, these results critically suggest that aging results in temporally lagged activity even in regions not typically associated with cognitive control, such as the MTL. PMID:22114083

  4. Technical bases DWPF Late Washing Facility. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Fish, D.L.; Landon, L.F.

    1992-08-10

    A task force recommended that the technical feasibility of a ``Late Wash` facility be assessed [1]. In this facility, each batch of tetraphenylborate slurry from Tank 49 would be given a final wash to reduce the concentrations of nitrite and radiolysis products to acceptable levels. Laboratory-scale studies have demonstrated that d the nitrite content of the slurry fed to DWPF is reduced to 0.01 M or less (and at least a 4X reduction in concentration of the soluble species is attained), (1) the need for HAN during hydrolysis is eliminated (eliminating the production of ammonium ion during hydrolysis), (2) hydrolysis may be done with a catalyst concentration that will not exceed the copper solubility in glass and (3) the non-polar organic production during hydrolysis is significantly reduced. The first phase of an aggressive research and development program has been completed and all test results obtained to date support the technical feasibility of Late Washing. Paralleling this research and development effort is an aggressive design study directed by DWPF to scope and cost retrofitting the Auxiliary Pump Pit (APP) to enable performing a final wash of each batch of precipitate slurry before R is transferred into the DWPF Soft Processing Cell (SPC). An initial technical bases for the Late Wash Facility was transmitted to DWPF on June 15, 1992. Research and development activities are continuing directed principally at optimization of the cross-f low fitter decontamination methodology and pilot-scale validation of the recommended benzene stripping metodology.

  5. Late preterm infants’ motor development until term age

    Science.gov (United States)

    Santos, Viviane Martins; Formiga, Cibelle Kayenne Martins Roberto; de Mello, Paulo Roberto Bezerra; Leone, Cléa Rodrigues

    2017-01-01

    OBJECTIVES: To analyze the motor development of late preterm newborn infants (LPI) from birth to term-corrected age using the Test of Infant Motor Performance (TIMP) and to compare the obtained results with those of term infants at birth. METHODS: Prospective cohort study, 29 late preterm newborn infants were evaluated by the TIMP at birth and every two weeks until term-corrected age. The TIMP was administered to 88 term infants at birth. RESULTS: The mean TIMP score of late preterm newborn infants was 51.9±5.8 at 34–35 weeks and 62.6±5.2 at 40 weeks. There was a significant increase at 38–39 weeks in the LPI group (p<0.05). There were no significant differences in the motor evaluations between term infants at birth and LPI at the equivalent age. CONCLUSION: The LPI presented a gradual progression of motor development until the term-corrected age, but differences with term infants at birth were not detected.

  6. Late Viséan pelagic chondrichthyans from northern Europe

    Directory of Open Access Journals (Sweden)

    Michał Ginter

    2015-12-01

    Full Text Available The relatively rich assemblages of shark teeth from pelagic limestone (Mississippian, late Viséan, late Asbian–middle Brigantian of three northern European regions: the Rhenish Mountains (Westenfeld Quarry, Germany, the Holy Cross Mountains (Todowa Grząba at the edge of Ostrówka Quarry, Poland, and Derbyshire (Cawdor Quarry, Matlock, England, UK display certain similarities, with the absolute predominance of the teeth of Falcatidae (small Symmoriiformes and the constant presence of Thrinacodus spp. The largest and most diverse assemblage from Todowa Grząba contains at least three species of a falcatid Denaea, a xenacanthimorph Bransonella nebraskensis, a newly described phoebodontid Thrinacodus dziki sp. nov., a few ctenacanthiform and euselachian teeth, and two abraded euchondrocephalan dental elements. Anachronistidae, common in the most of late Viséan pelagic faunas, are absent from Todowa Grząba and Westenfeld. The material under study differs from the shallow-water chondrichthyan fauna, hitherto described from the Mississippian carbonate platform facies, by its taxonomic content (particularly almost total absence of Euchondrocephali, generally lower diversity, and higher frequency of small teeth.

  7. Environmental roots of the late bronze age crisis.

    Science.gov (United States)

    Kaniewski, David; Van Campo, Elise; Guiot, Joël; Le Burel, Sabine; Otto, Thierry; Baeteman, Cecile

    2013-01-01

    The Late Bronze Age world of the Eastern Mediterranean, a rich linkage of Aegean, Egyptian, Syro-Palestinian, and Hittite civilizations, collapsed famously 3200 years ago and has remained one of the mysteries of the ancient world since the event's retrieval began in the late 19(th) century AD/CE. Iconic Egyptian bas-reliefs and graphic hieroglyphic and cuneiform texts portray the proximate cause of the collapse as the invasions of the "Peoples-of-the-Sea" at the Nile Delta, the Turkish coast, and down into the heartlands of Syria and Palestine where armies clashed, famine-ravaged cities abandoned, and countrysides depopulated. Here we report palaeoclimate data from Cyprus for the Late Bronze Age crisis, alongside a radiocarbon-based chronology integrating both archaeological and palaeoclimate proxies, which reveal the effects of abrupt climate change-driven famine and causal linkage with the Sea People invasions in Cyprus and Syria. The statistical analysis of proximate and ultimate features of the sequential collapse reveals the relationships of climate-driven famine, sea-borne-invasion, region-wide warfare, and politico-economic collapse, in whose wake new societies and new ideologies were created.

  8. The impact of fire on the Late Paleozoic Earth System

    Directory of Open Access Journals (Sweden)

    Ian J. Glasspool

    2015-09-01

    Full Text Available Analyses of bulk petrographic data indicate that during the Late Paleozoic wildfires were more prevalent than at present. We propose that the development of fire systems through this interval was controlled predominantly by the elevated atmospheric oxygen concentration (p(O2 that mass balance models predict prevailed. At higher levels of p(O2, increased fire activity would have rendered vegetation with high moisture contents more susceptible to ignition and would have facilitated continued combustion. We argue that coal petrographic data indicate that p(O2 rather than global temperatures or climate, resulted in the increased levels of wildfire activity observed during the Late Paleozoic and can therefore be used to predict it. These findings are based upon analyses of charcoal volumes in multiple coals distributed across the globe and deposited during this time period, and that were then compared with similarly diverse modern peats and Cenozoic lignites and coals. Herein, we examine the environmental and ecological factors that would have impacted fire activity and we conclude that of these factors p(O2 played the largest role in promoting fires in Late Paleozoic peat-forming environments and, by inference, ecosystems generally, when compared with their prevalence in the modern world.

  9. Environmental roots of the late bronze age crisis.

    Directory of Open Access Journals (Sweden)

    David Kaniewski

    Full Text Available The Late Bronze Age world of the Eastern Mediterranean, a rich linkage of Aegean, Egyptian, Syro-Palestinian, and Hittite civilizations, collapsed famously 3200 years ago and has remained one of the mysteries of the ancient world since the event's retrieval began in the late 19(th century AD/CE. Iconic Egyptian bas-reliefs and graphic hieroglyphic and cuneiform texts portray the proximate cause of the collapse as the invasions of the "Peoples-of-the-Sea" at the Nile Delta, the Turkish coast, and down into the heartlands of Syria and Palestine where armies clashed, famine-ravaged cities abandoned, and countrysides depopulated. Here we report palaeoclimate data from Cyprus for the Late Bronze Age crisis, alongside a radiocarbon-based chronology integrating both archaeological and palaeoclimate proxies, which reveal the effects of abrupt climate change-driven famine and causal linkage with the Sea People invasions in Cyprus and Syria. The statistical analysis of proximate and ultimate features of the sequential collapse reveals the relationships of climate-driven famine, sea-borne-invasion, region-wide warfare, and politico-economic collapse, in whose wake new societies and new ideologies were created.

  10. Late time solution for interacting scalar in accelerating spaces

    CERN Document Server

    Prokopec, Tomislav

    2015-01-01

    We consider stochastic inflation in an interacting scalar field in spatially homogeneous accelerating space-times with a constant principal slow roll parameter $\\epsilon$. We show that, if the scalar potential is scale invariant (which is the case when scalar contains quartic self-interaction and couples non-minimally to gravity), the late-time solution on accelerating FLRW spaces can be described by a probability distribution function (PDF) $\\rho$ which is a function of $\\varphi/H$ only, where $\\varphi=\\varphi(\\vec x)$ is the scalar field and $H=H(t)$ denotes the Hubble parameter. We give explicit late-time solutions for $\\rho\\rightarrow \\rho_\\infty(\\varphi/H)$, and thereby find the order $\\epsilon$ corrections to the Starobinsky-Yokoyama result. This PDF can then be used to calculate e.g. various $n-$point functions of the (self-interacting) scalar field, which are valid at late times in arbitrary accelerating space-times with $\\epsilon=$ constant.

  11. Early and late surgical site infections in ear surgery.

    Science.gov (United States)

    Bastier, P L; Leroyer, C; Lashéras, A; Rogues, A-M; Darrouzet, V; Franco-Vidal, V

    2016-04-01

    A retroauricular approach is routinely used for treating chronic otitis media. The incidence of surgical site infections after ear surgery is around 10% in contaminated or dirty procedures. This observational prospective study describes surgical site infections after chronic otitis media surgery with the retroauricular approach and investigated their potential predictive factors. This observational prospective study included patients suffering from chronic otitis media and eligible for therapeutic surgery with a retroauricular approach. During follow-up, surgical site infections were defined as "early" if occurring within 30 days after surgery or as "late" if occurring thereafter. The data of 102 patients were analysed. Concerning early surgical site infections, four cases were diagnosed (3.9%) and a significant association was found with preoperative antibiotic therapy, wet ear at pre-operative examination, class III (contaminated) in the surgical wound classification, NNIS (National Nosocomial Infection Surveillance) index > 1, and oral post-operative antibiotic use. Seven late surgical site infections were diagnosed (7.1%) between 90 and 160 days after surgery and were significantly correlated to otorrhoea during the 6 months before surgery, surgery duration ≤60 minutes, canal wall down technique and use of fibrin glue. Surgical site infections after chronic otitis media surgery seem to be associated with factors related to the inflammatory state of the middle ear at the time of surgery in early infections and with chronic inflammation in late infections. © Copyright by Società Italiana di Otorinolaringologia e Chirurgia Cervico-Facciale, Rome, Italy.

  12. Ultimate concerns in late modernity: Archer, Bourdieu and reflexivity.

    Science.gov (United States)

    Farrugia, David; Woodman, Dan

    2015-12-01

    Through a critique of Margaret Archer's theory of reflexivity, this paper explores the theoretical contribution of a Bourdieusian sociology of the subject for understanding social change. Archer's theory of reflexivity holds that conscious 'internal conversations' are the motor of society, central both to human subjectivity and to the 'reflexive imperative' of late modernity. This is established through critiques of Bourdieu, who is held to erase creativity and meaningful personal investments from subjectivity, and late modernity is depicted as a time when a 'situational logic of opportunity' renders embodied dispositions and the reproduction of symbolic advantages obsolete. Maintaining Archer's focus on 'ultimate concerns' in a context of social change, this paper argues that her theory of reflexivity is established through a narrow misreading and rejection of Bourdieu's work, which ultimately creates problems for her own approach. Archer's rejection of any pre-reflexive dimensions to subjectivity and social action leaves her unable to sociologically explain the genesis of 'ultimate concerns', and creates an empirically dubious narrative of the consequences of social change. Through a focus on Archer's concept of 'fractured reflexivity', the paper explores the theoretical necessity of habitus and illusio for understanding the social changes that Archer is grappling with. In late modernity, reflexivity is valorized just as the conditions for its successful operation are increasingly foreclosed, creating 'fractured reflexivity' emblematic of the complex contemporary interaction between habitus, illusio, and accelerating social change. © London School of Economics and Political Science 2015.

  13. Combined obliquity and precession pacing of late Pleistocene deglaciations.

    Science.gov (United States)

    Huybers, Peter

    2011-12-08

    Milankovitch proposed that Earth resides in an interglacial state when its spin axis both tilts to a high obliquity and precesses to align the Northern Hemisphere summer with Earth's nearest approach to the Sun. This general concept has been elaborated into hypotheses that precession, obliquity or combinations of both could pace deglaciations during the late Pleistocene. Earlier tests have shown that obliquity paces the late Pleistocene glacial cycles but have been inconclusive with regard to precession, whose shorter period of about 20,000 years makes phasing more sensitive to timing errors. No quantitative test has provided firm evidence for a dual effect. Here I show that both obliquity and precession pace late Pleistocene glacial cycles. Deficiencies in time control that have long stymied efforts to establish orbital effects on deglaciation are overcome using a new statistical test that focuses on maxima in orbital forcing. The results are fully consistent with Milankovitch's proposal but also admit the possibility that long Southern Hemisphere summers contribute to deglaciation.

  14. Obliquity pacing of the late Pleistocene glacial terminations.

    Science.gov (United States)

    Huybers, Peter; Wunsch, Carl

    2005-03-24

    The 100,000-year timescale in the glacial/interglacial cycles of the late Pleistocene epoch (the past approximately 700,000 years) is commonly attributed to control by variations in the Earth's orbit. This hypothesis has inspired models that depend on the Earth's obliquity (approximately 40,000 yr; approximately 40 kyr), orbital eccentricity (approximately 100 kyr) and precessional (approximately 20 kyr) fluctuations, with the emphasis usually on eccentricity and precessional forcing. According to a contrasting hypothesis, the glacial cycles arise primarily because of random internal climate variability. Taking these two perspectives together, there are currently more than thirty different models of the seven late-Pleistocene glacial cycles. Here we present a statistical test of the orbital forcing hypothesis, focusing on the rapid deglaciation events known as terminations. According to our analysis, the null hypothesis that glacial terminations are independent of obliquity can be rejected at the 5% significance level, whereas the corresponding null hypotheses for eccentricity and precession cannot be rejected. The simplest inference consistent with the test results is that the ice sheets terminated every second or third obliquity cycle at times of high obliquity, similar to the original proposal by Milankovitch. We also present simple stochastic and deterministic models that describe the timing of the late-Pleistocene glacial terminations purely in terms of obliquity forcing.

  15. Early and late vulval cancer recurrences: Are they different?

    Science.gov (United States)

    Ragupathy, Kalpana; Grandidge, Lisa; Strelley, Katie; Wang, Huan; Tidy, John

    2016-05-01

    Vulval cancers are rare, but after primary treatment, known to recur with a high frequency (30%). Clinico-pathological predictors of recurrence have been established to a great extent. However, there is paucity of literature on predictors of early versus late recurrence. We sought to identify such predictors through a retrospective study of vulval cancer recurrences in a single cancer centre over 11 years. Age of women, depth of invasion/site of primary tumour and presence of background VIN/lichen sclerosus do not appear to affect timing of recurrence. However, vulval cancers that recur after 2 years of primary tumour recognition are more likely to be well-differentiated tumours, have undergone radical surgery and have had a closest disease-free margin >1 cm. Late recurrences are entirely local rather than distant metastases and this translates into a better survival as shown in our study (40 months median survival in the early group versus 112 in the late recurrence group).

  16. Late-stage galaxy mergers in COSMOS to z~1

    CERN Document Server

    Lackner, C N; Salvato, M; Kampczyk, P; Kartaltepe, J S; Sanders, D; Capak, P; Civano, F; Ilbert, O; Jahnke, K; Koekemoer, A M; Lee, N; Fevre, O Le; Liu, C T; Scoville, N; Sheth, K; Toft, S

    2014-01-01

    The role of major mergers in galaxy and black hole formation is not well constrained. To help address this, we develop an automated method to identify late-stage galaxy mergers before coalescence of the galactic cores. The resulting sample of mergers is distinct from those obtained using pair-finding and morphological indicators. Our method relies on median-filtering of high-resolution images in order to distinguish two concentrated galaxy nuclei at small separations. Using mock images, we derive statistical contamination and incompleteness corrections for the fraction of late-stage mergers. We apply our new method to a magnitude-limited (I 10.6$ and $0.25 < z \\leq 1.00$, we find ~5% of systems are late-stage mergers with separations between 2.2 and 8 kpc. Correcting for incompleteness and contamination, the fractional merger rate increases strongly with redshift as $(1+z)^{3.8\\pm0.9}$, in agreement with earlier studies and with dark matter halo merger rates. Separating the sample into star-forming and qu...

  17. Neurogenesis, Exercise, and Cognitive Late Effects of Pediatric Radiotherapy

    Directory of Open Access Journals (Sweden)

    Shaefali P. Rodgers

    2013-01-01

    Full Text Available Brain cancer is a common type of childhood malignancy, and radiotherapy (RT is a mainstay of treatment. RT is effective for tumor eradication, and survival rates are high. However, RT damages the brain and disrupts ongoing developmental processes, resulting in debilitating cognitive “late” effects that may take years to fully manifest. These late effects likely derive from a long-term decrement in cell proliferation, combined with a neural environment that is hostile to plasticity, both of which are induced by RT. Long-term suppression of cell proliferation deprives the brain of the raw materials needed for optimum cognitive performance (such as new neurons in the hippocampus and new glia in frontal cortex, while chronic inflammation and dearth of trophic substances (such as growth hormone limit neuroplastic potential in existing circuitry. Potential treatments for cognitive late effects should address both of these conditions. Exercise represents one such potential treatment, since it has the capacity to enhance cell proliferation, as well as to promote a neural milieu permissive for plasticity. Here, we review the evidence that cognitive late effects can be traced to RT-induced suppression of cell proliferation and hostile environmental conditions, as well as emerging evidence that exercise may be effective as an independent or adjuvant therapy.

  18. Evolutionary transition of dental formula in Late Cretaceous eutherian mammals

    Science.gov (United States)

    Averianov, Alexander O.; Archibald, J. David

    2015-10-01

    Kulbeckia kulbecke, stem placental mammal from the Late Cretaceous of Uzbekistan, shows a transitional stage of evolution in the dental formula from five to four premolars. A non-replaced dP3/dp3 may occur as individual variation. In other specimens, the lower premolars are crowded with no space for development of dp3. As is evident from the CT scanning of one juvenile specimen, the development of dp3 started in a late ontogenetic stage and was confined to the pulp cavity of the developing p2. This dp3 would have been resorbed in a later ontogenetic stage, as the roots of p2 formed. The initial stage of reduction of the third premolar can be traced to stem therians ( Juramaia and Eomaia), which have both dP3 and P3 present in the adult dentition. Further delay in the development of dP3/dp3 led to the loss of the permanent P3/p3 (a possible synapomorphy for Eutheria). The dP3/dp3 was present during most of the adult stages in the Late Cretaceous stem placentals Zhelestidae and Gypsonictops. This tooth is totally absent in basal taxa of Placentalia, which normally have at most four premolars.

  19. Job shop scheduling problem with late work criterion

    Science.gov (United States)

    Piroozfard, Hamed; Wong, Kuan Yew

    2015-05-01

    Scheduling is considered as a key task in many industries, such as project based scheduling, crew scheduling, flight scheduling, machine scheduling, etc. In the machine scheduling area, the job shop scheduling problems are considered to be important and highly complex, in which they are characterized as NP-hard. The job shop scheduling problems with late work criterion and non-preemptive jobs are addressed in this paper. Late work criterion is a fairly new objective function. It is a qualitative measure and concerns with late parts of the jobs, unlike classical objective functions that are quantitative measures. In this work, simulated annealing was presented to solve the scheduling problem. In addition, operation based representation was used to encode the solution, and a neighbourhood search structure was employed to search for the new solutions. The case studies are Lawrence instances that were taken from the Operations Research Library. Computational results of this probabilistic meta-heuristic algorithm were compared with a conventional genetic algorithm, and a conclusion was made based on the algorithm and problem.

  20. Late Sarmatian Elite Military Burial From the Southern Urals

    Directory of Open Access Journals (Sweden)

    Krivosheev Mikhail Vasilyevich

    2015-12-01

    Full Text Available The article is devoted to the burial of a warrior of Late Sarmatian time from the Southern Urals. The complex from mound no. 4 of the burial mound Taksai I is distinguished by large size of barrow and grave. The reconstructed height of the mound was less than 2 meters. The depth of the burial pit was more than 3 meters. For Late Sarmatian culture such dimensions of sepulchral structures are unique. Under the mound the ritual platform from mainland soil was discovered. The found inventory of a warrior-rider included: horse bridle, a set of bladed weapons consisting of a long sword, dagger and knife, as well as a small bronze cauldron. Analysis of inventory allows us to date this burial to the second half of the 3rd century A.D. This burial belongs to an elite funerary complexes of Late Sarmatian culture and is a burial of professional warriors. This social stratum was formed in Late Sarmatian society at the end of the 2nd - first half of the 3rd century A.D. Most of these graves are dating back to the first half of the 3rd century A.D and were found in the Low Don and in the Volga region. The situation in these regions changed in that period due to the invasion of the tribes of the North-Caucasian origin. Their occurrence is associated with the destruction of the Tanais in the Lower Don region and the spread of graves in the T-shaped catacombs in the steppe monuments. The tradition of burying warriors-horsemen of high social status almost disappears in the Volga-Don steppes after the middle of 3rd century A.D. In the Southern Urals where these processes had an indirect influence, the existence of traditional hierarchies of Late Sarmatian society could continue until the end of the 3rd century A.D. Among the parts of a horse bridle the researchers discovered bronze B-shape buckle. These buckles are widely distributed in the 4th-5th centuries A.D. in the basin of the Kama river and the Danube river. The found buckle is the earliest currently known

  1. Elevated C-Reactive Protein Associated With Late- and Very-Late-Onset Schizophrenia in the General Population

    DEFF Research Database (Denmark)

    Wium-Andersen, Marie Kim; Orsted, David Dynnes; Nordestgaard, Børge Grønne

    2013-01-01

    with increased risk of late- and very-late-onset schizophrenia in the general population, and if such an association possibly is causal. Method: We analyzed data from 78 810 men and women, aged 20-100 years, from 2 large population studies. Endpoints were hospitalization with schizophrenia and schizophrenia......Background: Individuals with autoimmune diseases and severe infections have persistent or acutely elevated inflammatory biomarkers and increased risk of schizophrenia. We tested the hypothesis that baseline elevated plasma levels of the inflammatory biomarker, C-reactive protein (CRP), associate...... and schizophrenia-like psychosis combined. We performed prospective and cross-sectional analyses adjusted for potential confounders with up to 20 years of follow-up. Furthermore, we used genetic variants influencing plasma CRP levels to perform a Mendelian randomization study. Results: Age- and gender...

  2. 76 FR 72952 - Guidance for Industry on Nonclinical Evaluation of Late Radiation Toxicity of Therapeutic...

    Science.gov (United States)

    2011-11-28

    ... a guidance for industry entitled ``Nonclinical Evaluation of Late Radiation Toxicity of Therapeutic... guidance represents the Agency's current thinking on nonclinical evaluation of late radiation toxicity of... HUMAN SERVICES Food and Drug Administration Guidance for Industry on Nonclinical Evaluation of...

  3. 75 FR 38589 - Culturally Significant Objects Imported for Exhibition Determinations: “Salvador Dali: The Late...

    Science.gov (United States)

    2010-07-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Salvador Dali: The Late Work... that the objects to be ] included in the exhibition ``Salvador Dali: The Late Work,'' imported...

  4. Management of late/very late stent thrombosis: Utility of ıntravenous ultrasonography (IVUS) in clinical practise

    OpenAIRE

    Emre Yalçınkaya; Barış Bugan; Yalçın Gökoğlan; Erkan Yıldırım

    2013-01-01

    To the editor We read with great interest the article by Aksu et al. [1] on the management of very late bare metal stent thrombosis. They performed intracoronary thrombus aspiration and inflated balloon in-stent for restenosis. During percutaneous coronary interventions, interventionalists have often to deal with thrombus-laden lesions in coronary vessels. Plaque characteristics and distribution, severity and extent of calcification, arterial remodeling and the presence of dissection or throm...

  5. File list: ALL.Emb.10.AllAg.Late_embryo [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Emb.10.AllAg.Late_embryo ce10 All antigens Embryo Late embryo SRX146416,SRX3313...X043867 http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/assembled/ALL.Emb.10.AllAg.Late_embryo.bed ...

  6. Prevalence and Morbidity of Late Preterm Infants: Current Status in a Medical Center of Northern Taiwan

    Directory of Open Access Journals (Sweden)

    Ming-Luen Tsai

    2012-06-01

    Conclusion: Late-preterm infants have increased risk of neonatal morbidities associated with organ immaturity. The results of this study emphasize the importance of judicious obstetrical decision-making when considering late preterm delivery, and the need to set up anticipatory clinical guidelines for the care of late preterm infants.

  7. Parental and Late Adolescent Psychopathology: Mothers May Provide Support When Needed Most

    Science.gov (United States)

    McKinney, Cliff; Milone, Mary Catherine

    2012-01-01

    Research links negative parenting and parental psychopathology to poorer outcomes among youth. Less research examines these effects simultaneously during late adolescence. The current study examines parenting, parental psychopathology, and late adolescent psychopathology as reported by late adolescents (N = 328) with the use of structural equation…

  8. Parental and Late Adolescent Psychopathology: Mothers May Provide Support When Needed Most

    Science.gov (United States)

    McKinney, Cliff; Milone, Mary Catherine

    2012-01-01

    Research links negative parenting and parental psychopathology to poorer outcomes among youth. Less research examines these effects simultaneously during late adolescence. The current study examines parenting, parental psychopathology, and late adolescent psychopathology as reported by late adolescents (N = 328) with the use of structural equation…

  9. African American Late Adolescents' Relationships with Parents: Developmental Transitions and Longitudinal Patterns

    Science.gov (United States)

    Smetana, Judith G.; Metzger, Aaron; Campione-Barr, Nicole

    2004-01-01

    Five-year longitudinal patterns and the influence of developmental transitions on 76 middle-class African American late adolescents' (M18.43 years) relationships with parents were examined. Late adolescents were closer to mothers than to fathers. Controlling for age, late adolescent females who had left home reported less negative relationships…

  10. Late Talkers: A Population-Based Study of Risk Factors and School Readiness Consequences

    Science.gov (United States)

    Hammer, Carol Scheffner; Morgan, Paul; Farkas, George; Hillemeier, Marianne; Bitetti, Dana; Maczuga, Steve

    2017-01-01

    Purpose: This study was designed to (a) identify sociodemographic, pregnancy and birth, family health, and parenting and child care risk factors for being a late talker at 24 months of age; (b) determine whether late talkers continue to have low vocabulary at 48 months; and (c) investigate whether being a late talker plays a unique role in…

  11. Accuracy of self-reported sleep position in late pregnancy.

    Directory of Open Access Journals (Sweden)

    Jane Warland

    Full Text Available There is emerging research to suggest that supine maternal sleep position in late pregnancy may adversely affect fetal wellbeing. However, these studies have all been based on maternal report of sleeping position. Before recommendations to change sleep position can be made it is important to determine the validity of these studies by investigating how accurate pregnant women are in reporting their sleep position. If avoiding the supine sleeping position reduces risk of poor pregnancy outcome, it is also important to know how well women can comply with the instruction to avoid this position and sleep on their left.Thirty women in late pregnancy participated in a three-night observational study and were asked to report their sleeping position. This was compared to sleep position as recorded by a night capable video recording. The participants were instructed to settle to sleep on their left side and if they woke overnight to settle back to sleep on their left.There was a moderate correlation between reported and video-determined left-side sleep time (r = 0.48, mean difference = 3 min (SD = 3.5 h. Participants spent an average of 59.60% (SD = 16.73% of time in bed on their left side (ICC across multiple nights = 0.67. Those who included left side among their typical sleep positions reported significantly longer sleep during the study (p<0.01.On average participant reports of sleep position were relatively accurate but there were large individual differences in reporting accuracy and in objectively-determined time on left side. Night-to-night consistency was substantial. For those who do not ordinarily sleep on that side, asking participants to sleep on their left may result in reduced sleep duration. This is an important consideration during a sleep-critical time such as late pregnancy.

  12. Late Quaternary loss of genetic diversity in muskox (Ovibos

    Directory of Open Access Journals (Sweden)

    Mol Dick

    2005-10-01

    Full Text Available Abstract Background The modern wildherd of the tundra muskox (Ovibos moschatus is native only to the New World (northern North America and Greenland, and its genetic diversity is notably low. However, like several other megafaunal mammals, muskoxen enjoyed a holarctic distribution during the late Pleistocene. To investigate whether collapse in range and loss of diversity might be correlated, we collected mitochondrial sequence data (hypervariable region and cytochrome b from muskox fossil material recovered from localities in northeastern Asia and the Arctic Archipelago of northern North America, dating from late Pleistocene to late Holocene, and compared our results to existing databases for modern muskoxen. Results Two classes of haplotypes were detected in the fossil material. "Surviving haplotypes" (SHs, closely similar or identical to haplotypes found in modern muskoxen and ranging in age from ~22,000 to ~160 yrbp, were found in all New World samples as well as some samples from northeastern Asia. "Extinct haplotypes" (EHs, dating between ~44,000 and ~18,000 yrbp, were found only in material from the Taimyr Peninsula and New Siberian Islands in northeastern Asia. EHs were not found in the Holocene muskoxen specimens available for this study, nor have they been found in other studies of extant muskox populations. Conclusion We provisionally interpret this evidence as showing that genetic variability was reduced in muskoxen after the Last Glacial Maximum but before the mid-Holocene, or roughly within the interval 18,000-4,000 yrbp. Narrowing this gap further will require the recovery of more fossils and additional genetic information from this interval.

  13. Late Cretaceous tectonic framework of the Tibetan Plateau

    Science.gov (United States)

    Wu, Zhenhan; Barosh, Patrick J.; Ye, Peisheng; Hu, Daogong

    2015-12-01

    New research, coupled with previous data, reveals the Late Cretaceous paleo-geography, and related paleo-tectonic movement of the Tibetan Plateau. A vast ocean, the Neo-Tethys Ocean, perhaps as wide as ∼7000 km, existed between the Indian and Eurasian Continental Plates in the early Late Cretaceous. In addition, a Himalaya Marginal Sea lay along the border of the Indian Plate and other marginal seas were present to the north in both the southern Lhasa and southwestern Tarim Blocks. Northward subduction of the Neo-Tethys Oceanic Plate along the Yalung-Zangbu Suture closed most of the ocean and led to intensive thrusting, tight folding, magmatic plutonism and volcanic eruptions in the central plateau to the north. A magmatic arc up to 500 km wide formed across the southern margin of the continental plate in central Tibet and its varying granitic composition appears to reflect the depth to the subducted plate and define its geometry. A series of large, chiefly north-dipping thrust systems also developed across central Tibet. These include thrusts along the Yalung-Zangbu and Bangong-Nujiang Sutures, the North Gangdese and North Lhasa Thrusts in the Lhasa Block, the Qiangtang and North Tangula Thrusts in the Qiangtang block, the Hoh-Xil and Bayan Har Thrusts in the Hoh-Xil Block, as well as the sinistral-slip South Kunlun and Altyn Tagh Faults in northern Tibet. Uplifts formed above the hanging walls of the major thrusts and their eroded debris formed thick red-beds in basins below them. The central Tibetan Plateau maintained a low elevation and coastal vegetation was dominant during the Late Cretaceous.

  14. Late onset myoclonic epilepsy in Down syndrome and dementia

    Directory of Open Access Journals (Sweden)

    Annapia Verri

    2012-09-01

    Full Text Available Specific forms of epilepsy may be found at various ages in Down Syndrome (DS and a sharp increase in the incidence of epilepsy with age has been documented. A specific type of myoclonic epilepsy associated with cognitive decline has been reported as “senile myoclonic epilepsy” or “late onset myoclonic epilepsy in DS” (LOMEDS. We report a new case of LOMEDS, documented by clinical and neurophysiological evaluation and psychometric assessment (DSDS and DMR. MF, male, affected by DS, was referred in 2004 at 40 years of age; he had no personal or familial history of epilepsy. Since one year, the patient presented cognitive deterioration, characterized by regression of language abilities, loss of memory, and loss of sphincters control. A brain TC showed mild brainstem and sub-cortical atrophy. In 2006, myoclonic jerks involving upper limbs occurred mainly after awakening. EEG showed a low voltage 8 Hz background activity with diffuse slow activity, intermingled with spikes or polyspikes, persisting during NREM sleep. MF was initially treated with clonazepam and after with topiramate, resulting in partial seizures control. MRI (2008 demonstrated diffuse brain atrophy, associated with marked ventricular enlargement. At the psychometric evaluation, onset of dementia was evident late in 2004, with transition to the middle stage in 2006. Last assessment (2009 showed the clinical signs of a late stage of deterioration, with loss of verbal abilities and autonomous ambulation. Using levetiracetam till 2,000 mg/die, myoclonic jerks decreased but are still present every day after awakening. On the EEG slow and poorly organized background activity with bilateral polyspike-wave discharges was recorded. Therefore, we documented a parallel progression of dementia and myoclonic epilepsy in a DS subject.

  15. Management of late postoperative complications of bariatric surgery.

    Science.gov (United States)

    Hamdan, K; Somers, S; Chand, M

    2011-10-01

    The prevalence of obesity is increasing worldwide and the past decade has witnessed an exponential rise in the number of bariatric operations performed. As a consequence, an increasing number of patients are presenting to non-specialist units with complications following bariatric procedures. This article outlines the management of the most common late postoperative complications that are likely to present to the general surgeon. A search was conducted for late postoperative complications after bariatric surgery using PubMed, Embase, OVID and Google search engines, and combinations of the terms bariatric surgery, gastric bypass, gastric banding or sleeve gastrectomy, and late or delayed complications. Only studies with follow-up longer than 6 months were included. The most common long-term complications after gastric banding include band slippage and erosion. Deflation or removal of the band is often required. Internal hernia, adhesions and anastomotic stenosis are common causes of intestinal obstruction after gastric bypass surgery. Hepatobiliary complications pose a particular challenge because of the altered anatomy. Functional disorders such as reflux and dumping, and nutritional deficiencies are common and should be differentiated from conditions that require urgent investigations and timely surgical intervention. The immediate management of bariatric patients presenting with complications outside the immediate postoperative period requires adherence to basic surgical principles. Accurate diagnosis often relies on high-quality contrast and cross-sectional imaging, and effective surgical intervention necessitates a broad understanding of the altered anatomy, advanced surgical skills and liaison with specialists in the field when necessary. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.

  16. Detection of lithium in nearby young late-M dwarfs

    Science.gov (United States)

    Phan-Bao, N.; Bessell, M. S.; Nguyen-Thanh, D.; Martín, E. L.; Ho, P. T. P.; Lee, C. F.; Parsons, H.

    2017-03-01

    Context. Late M-type dwarfs in the solar neighborhood include a mixture of very low-mass stars and brown dwarfs that is difficult to disentangle due to the lack of constraints on their age, such as trigonometric parallax, lithium detection, and space velocity. Aims: We search for young brown dwarf candidates among a sample of 28 nearby late-M dwarfs with spectral types between M5.0 and M9.0, and we also search for debris disks around three of them. Methods: Based on theoretical models, we used the color I-J, the J-band absolute magnitude, and the detection of the Li I 6708 Å doublet line as a strong constraint to estimate masses and ages of our targets. For the search of debris disks, we observed three targets at submillimeter wavelength of 850 μm. Results: We report here the first clear detections of lithium absorption in four targets and a marginal detection in one target. Our mass estimates indicate that two of them are young brown dwarfs, two are young brown dwarf candidates, and one is a young very low-mass star. The closest young field brown dwarf in our sample at only 15 pc is an excellent benchmark for further studying physical properties of brown dwarfs in the range 100-150 Myr. We did not detect any debris disks around three late-M dwarfs, and we estimated upper limits to the dust mass of debris disks around them. The reduced spectra (FITS files) are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/600/A19

  17. Proton Radiotherapy for Parameningeal Rhabdomyosarcoma: Clinical Outcomes and Late Effects

    Energy Technology Data Exchange (ETDEWEB)

    Childs, Stephanie K. [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (United States); Kozak, Kevin R. [Department of Radiation Oncology, University of Wisconsin Cancer Center Johnson Creek, Madison, WI (United States); Friedmann, Alison M. [Department of Pediatric Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (United States); Yeap, Beow Y. [Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA (United States); Adams, Judith; MacDonald, Shannon M.; Liebsch, Norbert J.; Tarbell, Nancy J. [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (United States); Yock, Torunn I., E-mail: tyock@partners.org [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (United States)

    2012-02-01

    Purpose: To report the clinical outcome and late side effect profile of proton radiotherapy in the treatment of children with parameningeal rhabdomyosarcoma (PM-RMS). Methods and Materials: Seventeen consecutive children with PM-RMS were treated with proton radiotherapy at Massachusetts General Hospital between 1996 and 2005. We reviewed the medical records of all patients and asked referring physicians to report specific side effects of interest. Results: Median patient age at diagnosis was 3.4 years (range, 0.4-17.6). Embryonal (n = 11), alveolar (n = 4), and undifferentiated (n = 2) histologies were represented. Ten patients (59%) had intracranial extension. Median prescribed dose was 50.4 cobalt gray equivalents (GyRBE) (range, 50.4-56.0 GyRBE) delivered in 1.8-2.0-GyRBE daily fractions. Median follow-up was 5.0 years for survivors. The 5-year failure-free survival estimate was 59% (95% confidence interval, 33-79%), and overall survival estimate was 64% (95% confidence interval, 37-82%). Among the 7 patients who failed, sites of first recurrence were local only (n = 2), regional only (n = 2), distant only (n = 2), and local and distant (n = 1). Late effects related to proton radiotherapy in the 10 recurrence-free patients (median follow-up, 5 years) include failure to maintain height velocity (n = 3), endocrinopathies (n = 2), mild facial hypoplasia (n = 7), failure of permanent tooth eruption (n = 3), dental caries (n = 5), and chronic nasal/sinus congestion (n = 2). Conclusions: Proton radiotherapy for patients with PM-RMS yields tumor control and survival comparable to that in historical controls with similar poor prognostic factors. Furthermore, rates of late effects from proton radiotherapy compare favorably to published reports of photon-treated cohorts.

  18. Apathy in late-life depression: common, persistent, and disabling.

    Science.gov (United States)

    Yuen, Genevieve S; Bhutani, Saumya; Lucas, Bryony J; Gunning, Faith M; AbdelMalak, Bassem; Seirup, Joanna K; Klimstra, Sibel A; Alexopoulos, George S

    2015-05-01

    The aims of this study were to examine: (1) the relationship between apathy and disability in late-life depression, and (2) the functional significance of improvement in apathy following escitalopram treatment in terms of its relationship to disability. Subjects were 71 non-demented elderly with non-psychotic major depression. After a 2-week single-blind placebo period, subjects who had Hamilton Depression Rating Scale (HDRS) ≥ 18 received escitalopram 10 mg daily for 12 weeks. Apathy and disability were assessed with the Apathy Evaluation Scale (AES) and the World Health Organization Disability Assessment Scale II (WHODAS), respectively. These measures and the HDRS were administered at baseline and again following 12 weeks of treatment. At baseline, 38% of depressed subjects had significant apathy (AES ≥ 36.5). Severity of apathy at baseline significantly correlated with severity of disability. In a multivariate regression model, baseline severity of apathy, but not the overall depressive syndrome (HDRS), significantly correlated with baseline disability. Following escitalopram treatment, improvement in apathy significantly correlated with improvement in disability measures, while change in the rest of the depressive syndrome did not. The overall change in apathy and disability in response to escitalopram treatment was significant but small. Apathy is common in late-life depression and is associated with disability above and beyond the influence of other depressive symptoms. Given the strong relationship between apathy and disability, understanding the neurobiology of apathy and developing treatments for apathy may improve the functional outcomes of late-life depression. Copyright © 2015 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.

  19. Late-Onset Hypogonadism and Testosterone Replacement in Older Men.

    Science.gov (United States)

    Bhattacharya, Rajib K; Bhattacharya, Shelley B

    2015-11-01

    Late-onset hypogonadism is an underdiagnosed and easily treated condition defined by low serum testosterone levels in men older than 65 years. When treated, a significant improvement in quality of life may be reached in this rapidly rising sector of the population. During the evaluation, laboratory tests and a full medication review should be performed to exclude other illnesses or adverse effects from medications. The major goal of treatment in this population is treating the symptoms related to hypogonadism. There has not been clear evidence supporting universally giving older men with low serum testosterone levels and hypogonadal symptoms testosterone replacement therapy.

  20. Transcriptional analysis of late ripening stages of grapevine berry

    Directory of Open Access Journals (Sweden)

    Guillaumie Sabine

    2011-11-01

    Full Text Available Abstract Background The composition of grapevine berry at harvest is a major determinant of wine quality. Optimal oenological maturity of berries is characterized by a high sugar/acidity ratio, high anthocyanin content in the skin, and low astringency. However, harvest time is still mostly determined empirically, based on crude biochemical composition and berry tasting. In this context, it is interesting to identify genes that are expressed/repressed specifically at the late stages of ripening and which may be used as indicators of maturity. Results Whole bunches and berries sorted by density were collected in vineyard on Chardonnay (white cultivar grapevines for two consecutive years at three stages of ripening (7-days before harvest (TH-7, harvest (TH, and 10-days after harvest (TH+10. Microvinification and sensory analysis indicate that the quality of the wines made from the whole bunches collected at TH-7, TH and TH+10 differed, TH providing the highest quality wines. In parallel, gene expression was studied with Qiagen/Operon microarrays using two types of samples, i.e. whole bunches and berries sorted by density. Only 12 genes were consistently up- or down-regulated in whole bunches and density sorted berries for the two years studied in Chardonnay. 52 genes were differentially expressed between the TH-7 and TH samples. In order to determine whether these genes followed a similar pattern of expression during the late stages of berry ripening in a red cultivar, nine genes were selected for RT-PCR analysis with Cabernet Sauvignon grown under two different temperature regimes affecting the precocity of ripening. The expression profiles and their relationship to ripening were confirmed in Cabernet Sauvignon for seven genes, encoding a carotenoid cleavage dioxygenase, a galactinol synthase, a late embryogenesis abundant protein, a dirigent-like protein, a histidine kinase receptor, a valencene synthase and a putative S

  1. Role of rice PPS in late vegetative and reproductive growth

    OpenAIRE

    Tanaka, Nobuhiro; Itoh, Jun-Ichi; Nagato, Yasuo

    2012-01-01

    The rice peter pan syndrome-1 (pps-1) mutant shows a prolonged juvenile phase and early flowering. Although the early vegetative phase and flowering time of pps-1 have been closely examined, the phenotypes in the late vegetative and reproductive phases are not yet well understood. In the ninth leaf blade of pps-1, the relative length of the midrib was comparable to the sixth leaf blade of wild-type. Moreover, pps-1 had a small inflorescence meristem and small panicles. These phenotypes indica...

  2. Analysis of electric vehicle's trip cost allowing late arrival

    Science.gov (United States)

    Leng, Jun-Qiang; Liu, Wei-Yi; Zhao, Lin

    2017-05-01

    In this paper, we use a car-following model to study each electric vehicle's trip cost and the total trip cost allowing late arrival. The numerical result show that the electricity cost has great effects on each commuter's trip cost and the total trip costs and that these effects are dependent on each commuter's time headway at the origin, but the electricity cost has no prominent impacts on the minimum value of total trip cost under each commuter's different time headway at the origin.

  3. Nuclear pasta and supernova neutrinos at late times

    CERN Document Server

    Horowitz, C J; Caplan, M E; Fischer, T; Lin, Zidu; Newton, W G; O'Connor, E; Roberts, L F

    2016-01-01

    Nuclear pasta, with nucleons arranged into tubes, sheets, or other complex shapes, is expected in core collapse supernovae (SNe) at just below nuclear density. We calculate the additional opacity from neutrino-pasta coherent scattering using molecular dynamics simulations. We approximately include this opacity in simulations of SNe. We find that pasta slows neutrino diffusion and greatly increases the neutrino signal at late times of 10 or more seconds after stellar core collapse. This signal, for a galactic SN, should be clearly visible in large detectors such as Super-Kamiokande.

  4. Water governement and inland navigation. Veneto in Late Middle Ages

    Directory of Open Access Journals (Sweden)

    Ermanno Orlando

    2011-09-01

    Full Text Available This contribution focuses on rivers and navigable canals of  Veneto in the Late Middle Ages as trade and transport routes: they covered a main and hegemonic role in the traffic of the region, guaranteeing communication and providing the backbone for the communication network of that time. In particular, the contribution seeks to analyze the policies of the greatest communes of Veneto concerning government and guardianship of the rivers and discipline of navigation. The sources are primarily normative and legal sources, particularly the abundant production of communal statutes and pacts, the series of international agreements and privileges established between the communes in terms of traffic, communication networks and transport.

  5. Hypoxia, global warming, and terrestrial late Permian extinctions.

    Science.gov (United States)

    Huey, Raymond B; Ward, Peter D

    2005-04-15

    A catastrophic extinction occurred at the end of the Permian Period. However, baseline extinction rates appear to have been elevated even before the final catastrophe, suggesting sustained environmental degradation. For terrestrial vertebrates during the Late Permian, the combination of a drop in atmospheric oxygen plus climate warming would have induced hypoxic stress and consequently compressed altitudinal ranges to near sea level. Our simulations suggest that the magnitude of altitudinal compression would have forced extinctions by reducing habitat diversity, fragmenting and isolating populations, and inducing a species-area effect. It also might have delayed ecosystem recovery after the mass extinction.

  6. Late Onset Anorexia Nervosa Treated With Olanzapine: A Case Report

    Directory of Open Access Journals (Sweden)

    Paolo Santonastaso

    2008-12-01

    Full Text Available A case of late onset anorexia nervosa (AN treated with olanzapine is reported. The patient suffered AN onset at the age of 53 and was brought to our attention four years later in a very poor state of health due to extreme starvation and laxative abuse. She presented severe obsessions about food, a very disturbed body image, and “ascetic” rituals of self-punishment. There was no improvement of her symptoms with cognitive behavioural therapy, antidepressant drugs and inpatient nutritional therapy. After the prescription of olanzapine, the patient was more cooperative and able to maintain a stable acceptable weight, although her psychiatric and anorexic symptoms only improved partially.

  7. Four types of neoplasms in Asian sea bass (Lates calcarifer)

    Institute of Scientific and Technical Information of China (English)

    Ramalingam Vijayakumar; Kuzhanthaivel Raja; Vijayapoopathi Singaravel; Ayyaru Gopalakrishnan

    2015-01-01

    Objective:To describe and observe four types of neoplasms on different parts (external and internal organs) of an Asian sea bass (Lates calcarifer). Methods:The sample was collected from local fish landing center (south east coast of India). Histopathology of normal and tumour tissues were analyzed. Results:A total of 83 tumour masses (neoplasm) were recorded on the fish skin, also the neoplasms were recorded in internal organs of fish such as liver, stomach and ovary. Conclusions:Aetiology of such neoplasm’s are unknown, further more researches need to confirm the causative agent for this type of neoplasm.

  8. Late-Developing Supernumerary Premolars: Analysis of Different Therapeutic Approaches

    Directory of Open Access Journals (Sweden)

    Sergio Paduano

    2016-01-01

    Full Text Available This case series describes the different potential approaches to late-developing supernumerary premolars (LDSP. LDSP are supernumerary teeth (ST formed after the eruption of the permanent dentition; usually they develop in the premolar region of the upper and lower jaw. The choice to extract or to monitor the LDSP depends on many factors and has to be carefully planned due to the several risks that either the monitoring or the extraction could provoke. These four cases of LDSP showed different treatment plan alternatives derived from a scrupulous assessment of the clinical and radiographic information.

  9. Status cataplecticus as initial presentation of late onset narcolepsy.

    Science.gov (United States)

    Panda, Samhita

    2014-02-15

    Narcolepsy, one of the important causes of hypersomnia, is an under diagnosed sleep disorder. It has a bimodal age of onset around 15 and 35 years. It is characterized by the tetrad of excessive daytime sleepiness, cataplexy, hypnagogic/ hypnopompic hallucinations, and sleep paralysis. Cataplexy is by far the most predictive feature of narcolepsy. Status cataplecticus is the occurrence of cataplexy repeatedly for hours or days, a rare presentation of narcolepsy. This report describes an elderly gentleman with late onset narcolepsy in the sixth decade of life presenting with initial and chief symptom of status cataplecticus.

  10. Schwarzschild scalar wigs: spectral analysis and late time behavior

    CERN Document Server

    Barranco, Juan; Degollado, Juan Carlos; Diez-Tejedor, Alberto; Megevand, Miguel; Alcubierre, Miguel; Nunez, Dario; Sarbach, Olivier

    2013-01-01

    Using the Green's function representation technique, the late time behavior of localized scalar field distributions on Schwarzschild spacetimes is studied. Assuming arbitrary initial data we perform a spectral analysis, computing the amplitude of each excited quasi-bound mode without the necessity of performing dynamical evolutions. The resulting superposition of modes is compared with a traditional numerical evolution with excellent agreement; therefore, we have an efficient way to determine final black hole wigs. The astrophysical relevance of the quasi-bound modes is discussed in the context of scalar field dark matter models and the axiverse.

  11. The epidemiology of acne vulgaris in late adolescence

    Directory of Open Access Journals (Sweden)

    Lynn DD

    2016-01-01

    Full Text Available Darren D Lynn,1 Tamara Umari,1 Cory A Dunnick,2,3 Robert P Dellavalle2–4 1Department of Dermatology, University of Colorado School of Medicine, 2Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, 3Dermatology Service, US Department of Veterans Affairs, Eastern Colorado Health Care System, Denver, 4Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA Importance: Acne vulgaris is the most common skin condition affecting late adolescents across the globe. Although prior studies have evaluated epidemiologic patterns of acne vulgaris in various ethnicities and regions, adequate understanding of the worldwide burden of the disease associated with patients in their late adolescence (15–19-year olds remains lacking. Objective: To assess the global burden of the disease associated with acne vulgaris for late adolescents (15–19-year olds and provide an overview of the epidemiology, pathophysiology, and treatment options for acne in this population. Design: Database summary study. Setting: Global Burden of Disease Study 2010 database. Participants: Global Burden of Disease regions comprised countries with prevalence of acne vulgaris between the ages of 15 and 19 years. Main outcomes and measures: Geographic region-level disability-adjusted life year rates (per 100,000 persons associated with acne vulgaris in years 1990 through 2010. Median percentage change in disability-adjusted life year rates was estimated for each region across the specified study period. Conclusion and relevance: Acne vulgaris-associated disease burden exhibits global distribution and has continued to grow in prevalence over time within this population. This continued growth suggests an unmet dermatologic need worldwide for this disorder and potential opportunities for improved access and delivery of dermatologic care. Our analysis of the literature reveals numerous

  12. Comet or asteroid shower in the late Eocene?

    Science.gov (United States)

    Tagle, Roald; Claeys, Philippe

    2004-07-23

    The passage of a comet shower approximately 35 million years ago is generally advocated to explain the coincidence during Earth's late Eocene of an unusually high flux of interplanetary dust particles and the formation of the two largest craters in the Cenozoic, Popigai and the Chesapeake Bay. However, new platinum-group element analyses indicate that Popigai was formed by the impact of an L-chondrite meteorite. Such an asteroidal projectile is difficult to reconcile with a cometary origin. Perhaps instead the higher delivery rate of extraterrestrial matter, dust, and large objects was caused by a major collision in the asteroid belt.

  13. Fossil woods from the Late Cretaceous Aachen Formation.

    Science.gov (United States)

    Meijer

    2000-11-01

    Silicified fossil woods from the Late Cretaceous (Santonian) Aachen Formation of northeast Belgium, southernmost Netherlands and adjacent Germany were investigated. Gymnosperms dominate this assemblage: Taxodioxylon gypsaceum, T. cf. gypsaceum, T. cf. albertense (all Taxodiaceae), Dammaroxylon aachenense sp. nov. (Araucariaceae), Pinuxylon sp. (Pinaceae), and Scalaroxylon sp. (Cycad or Cycadeoid). Angiosperms are minor constituents: Nyssoxylon sp. (Nyssaceae?, Cornaceae?), Mastixioxylon symplocoides sp. nov. (Mastixiaceae?, Symplocaceae?), Plataninium decipiens (Platanaceae) and Paraphyllanthoxylon cf. marylandense (Anacardiaceae?, Burseraceae?, Lauraceae?).The composition of this assemblage and the anatomy of the woods indicate a seasonal and humid warm-temperate to subtropical climate.

  14. Late-onset monomelic amyotrophy in a Caucasian woman.

    Science.gov (United States)

    Patel, Dharmesh R; Knepper, Laurie; Jones, H Royden

    2008-01-01

    We describe a 53-year-old Caucasian woman with a 19-year history of an evolving amyotrophy confined to her dominant right arm and hand. Although this atypical case of a late-onset monomelic amyotrophy in some respects mimics Hirayama disease or O'Sullivan-McLeod syndrome, it does not conform precisely with either of those disorders. We compare this individual's difficulties and clinical temporal profile to other disorders considered in the differential diagnoses with regard to her evolving clinical setting.

  15. Capgras syndrome in a very late onset, treatment resistant schizophrenia.

    Science.gov (United States)

    Ain, M K Nurul; Rosdinom, R; Raynuha, M

    2015-09-01

    We report a Malay man, with underlying chronic medical illnesses, presenting with positive symptoms of schizophrenia, including Capgras syndrome (CS) at the age of 73. Physical examination and blood investigations were normal and brain CT scan showed age-related cerebral atrophy. Neuropsychological assessment showed probable right hemisphere lesions but relatively intact memory and intellectual functions. Several neuroleptics including depot injections were tried but ineffective. Positive symptoms including CS eventually improved with clozapine before his death from myocardial infarction. This case report highlights the uncommon occurrence of CS in treatment resistant schizophrenia (TRS) of very late onset and its treatment challenges.

  16. Late adverse reactions to intravascular iodine based contrast media

    DEFF Research Database (Denmark)

    Bellin, Marie-France; Stacul, Fulvio; Webb, Judith A W

    2011-01-01

    DEFINITION: Late adverse reactions (LAR) to contrast media (CM) are defined as reactions occurring 1 h to 1 week after exposure. NEED FOR REVIEW: In view of more prospective studies of LAR and new data about their pathophysiology, the Contrast Medium Safety Committee (CMSC) of the European Society...... or delayed reading intradermal). The main risk factors for LAR are a previous reaction to contrast medium, a history of allergy, and interleukin-2 treatment. Most skin reactions are mild or moderate and self-limiting. MANAGEMENT: Management is symptomatic and similar to the management of other drug...

  17. [Causes of late diagnosis of appendicitis in children].

    Science.gov (United States)

    Zlámal, Z

    1996-07-01

    The author evaluates the case-history of 51 children with perforated appendicitis treated during 1984-1995 at the First Surgical Clinic of the Faculty Hospital Olomouc. The purpose was to find an answer to the problem why in these children the diagnosis was delayed and whose was the fault of the substantial deterioration of the health status. In the evaluation four groups of causal responsibility are differentiated: a very rapid development of appendicitis-parents, arriving late in the surgery-paediatricians-surgeons. The authors discuss circumstances associated with the diagnostic error and delay.

  18. [Contribution to the history of pharmacology (the late antique period)].

    Science.gov (United States)

    Tesařová, Drahomíra

    2015-01-01

    Pharmacological literature in the Late Antique period followed the Roman tradition and widely used Scribonius Largus and excerpts from the writings of Pliny the Elder. Literature was created both in the western part of the Roman Empire and in North Africa in Carthage. Manuals have been written about medicinal plants (Herbarius of Pseudo-Apuleius, De herba vettonica of Pseudo-Musa), for drugs obtained from the animal kingdom (Liber medicinae of Sextus Placitus) or documents containing both (De medicina of Cassius Felix, De medicamentis of Marcellus Empiricus). The contribution of this literature is the mediation of ancient knowledge into the Middle Ages.

  19. BAURU GROUP (LATE CRETACEOUS VERTEBRATES FROM TRIÂNGULO MINEIRO

    Directory of Open Access Journals (Sweden)

    Carlos Roberto dos Anjos Candeiro

    2005-06-01

    Full Text Available The Triângulo Mineiro (Minas Gerais State and western São Paulo State have a rich and diversefauna of Late Cretaceous vertebrates from Adamantina, Uberaba and Marília formations (BauruGroup. This paper attempts to list the vertebrate fauna known from each formation within theTriângulo Mineiro region and western São Paulo using the most recent and accepted definition foreach formation or higher taxonomical group. The faunal list produced now gives us a clearerunderstanding of the stratigraphical distribution of the Bauru Group vertebrates.

  20. Kinematics of late paleozoic continental collision between laurentia and gondwana.

    Science.gov (United States)

    Sacks, P E; Secor, D T

    1990-12-21

    In the Appalachians, late Paleozoic Alleghanian orogenesis is widely regarded as resulting from dextral oblique collision between irregular margins of Gondwana and Laurentia. However, this relative plate motion cannot account for coeval convergence in the Ouachitas and Variscides and is incompatible with some tectonic transport indicators in the Appalachians. An alternative kinematic model is proposed in which early sinistral transpression in the Appalachians is followed by counterclockwise rotation of Gondwana and the development of a system of dextral strike-slip faults extending from southern Europe to Alabama.

  1. Representations of Late-Ottoman Thessaloniki in Contemporary Greek Literature

    DEFF Research Database (Denmark)

    Willert, Trine Stauning

    on the Ottoman period, this paper will present an analysis of representations of late Ottoman Thessaloniki in a number of Greek novels published between 2005 and 2012. The paper examines the ways in which these novels represent cross-cultural and cross-religious relations in pre-national Thessaloniki...... and it will be discussed how the contemporary fiction differs from earlier ‘nationalist’ Greek fiction about the Ottoman period. A significant characteristic of the contemporary novels is the explicit reference to extensive historiographic secondary literature and in some cases even historical sources. What does...

  2. Late Proterozoic extensional collapse in the Arabian-Nubian Shield

    OpenAIRE

    Blasband, B.B.; White, S H; Brooijmans, P.; Boorder, H. de; Visser, W.

    2000-01-01

    A structural and petrological study of the Late Proterozoic rocks in the Wadi Kid area, Sinai, Egypt indicates the presence of an extensional metamorphic core complex in the northern Arabian–Nubian Shield. Gneissic domes throughout the Arabian–Nubian Shield resemble the core complex of the Wadi Kid area and as a result, they are interpreted as extensional metamorphic core complexes. The presence of a widespread phase of extension at the end of the Pan-African period in the Arabian–Nubian Shie...

  3. Effect of vegetation on the Late Miocene ocean circulation

    Directory of Open Access Journals (Sweden)

    G. Lohmann

    2006-08-01

    Full Text Available A weak and shallow thermohaline circulation in the North Atlantic Ocean is related to an open Central American gateway and exchange with fresh Pacific waters. We estimate the effect of vegetation on the ocean general circulation using the atmospheric circulation model simulations for the Late Miocene climate. Caused by an increase in net evaporation in the Miocene North Atlantic, the North Atlantic water becomes more saline which enhances the overturning circulation and thus the northward heat transport. This effect reveals a potentially important feedback between the ocean circulation, the hydrological cycle and the land surface cover for Cenozoic climate evolution.

  4. Electronic structure of LaTe and CeTe

    Energy Technology Data Exchange (ETDEWEB)

    Chainani, A., E-mail: chainania@gmail.com [RIKEN SPring-8 Centre, 1-1-1 Kouto, Hyogo 679-5148 (Japan); Department of Physics, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578 (Japan); Oura, M. [RIKEN SPring-8 Centre, 1-1-1 Kouto, Hyogo 679-5148 (Japan); Matsunami, M. [UVSOR Facility, Institute for Molecular Science, Okazaki 444-8585 (Japan); Ochiai, A.; Takahashi, T. [Department of Physics, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578 (Japan); Tanaka, Y. [RIKEN SPring-8 Centre, 1-1-1 Kouto, Hyogo 679-5148 (Japan); Graduate School of Material Science, University of Hyogo, 3-2-1 Kouto, Hyogo 678-1297 (Japan); Tamasaku, K.; Kohmura, Y.; Ishikawa, T. [RIKEN SPring-8 Centre, 1-1-1 Kouto, Hyogo 679-5148 (Japan)

    2016-04-15

    Highlights: • Hard X-ray and soft X-ray photoelectron spectroscopy of LaTe and CeTe. • Evidence for Kondo screening in antiferromagnetic(T{sub N} = 2.2 K) compound CeTe. • Suppressed Kondo resonance in CeTe compared to typical Kondo materials. - Abstract: We report a comparative study of the electronic structure of the compounds LaTe and CeTe, both of which crystallize in the rock salt structure. LaTe is a paramagnetic metal while CeTe is known to exhibit anomalous Kondo-like transport behaviour and undergoes a transition to a complex magnetically ordered state at low temperature (T{sub N} = 2.2 K). We carry out hard X-ray photoelectron spectroscopy (HAXPES) of the core-levels and valence band of LaTe and CeTe at T = 20 K, in order to characterize their intrinsic electronic structure, and to address the role of Kondo effect on the electronic structure of CeTe. The bulk sensitive core level HAXPES spectra show evidence of screened features in the La 3d and Ce 3d states mixed with plasmon features. From a careful analysis of the Te, La and Ce derived core levels, we separate out the respective origins of the satellites and show that CeTe indeed exhibits definitive but weak f{sup 0} and f{sup 2} satellites due to Kondo screening, in addition to the main f{sup 1} peak. The comparison of the valence band spectra of CeTe obtained using HAXPES and soft X-ray PES clearly identifies the Ce 4f derived features. Resonant photoelectron spectrosocopy across the Ce 3d − 4f threshold confirms the Ce 4f{sup 1} final state at the Fermi level, corresponding to the tail of the Kondo resonance feature which occurs above the Fermi level, while the Ce 4f{sup 0} final state feature is observed at a binding energy of 2.4 eV. The 4f{sup 0} and 4f{sup 1} final states show giant resonances compared to the off-resonant spectra. However, in contrast to typical Kondo systems, the tail of the Ce 4f{sup 1} Kondo resonance at the Fermi level is relatively suppressed compared to the Ce 4f

  5. Adverse events with continuous doxapram infusion against late postoperative hypoxaemia

    DEFF Research Database (Denmark)

    Rosenberg, J; Kristensen, P A; Pedersen, M H

    1996-01-01

    OBJECTIVE: A randomized double-blind controlled trial of doxapram versus placebo against late postoperative hypoxaemia was planned to include 40 patients (2 x 20). RESULTS: After inclusion of 18 patients a serious adverse event was encountered with development of a brain stem infarction in a 90......-year-old woman receiving doxapram. At this point the randomization code was broken and we decided to terminate the trial. Three of nine patients receiving doxapram had had an adverse event whereas none of the patients receiving placebo had adverse events (P = 0.2). In the 18 patients studied...

  6. Faunal migration into the Late Permian Zechstein Basin

    DEFF Research Database (Denmark)

    Sørensen, Anne Mehlin; Håkansson, Eckart; Stemmerik, Lars

    2007-01-01

    the northern margin of Pangea is used to test hypotheses concerning Late Palaeozoic evolution of the North Atlantic region. During the Permian, the Atlantic rift system formed a seaway between Norway and Greenland from the boreal Barents Shelf to the warm and arid Zechstein Basin. This seaway is considered...... to be the only marine connection to the Zechstein Basin and therefore the only possible migration route for bryozoans to enter the basin. The distribution of Permian bryozoans is largely in keeping with such a connection from the cool Barents Shelf past the East Greenland Basin to the warm Zechstein Basin...

  7. [Antibiotic prophylaxis of immediate and late complications of scarlet fever].

    Science.gov (United States)

    Sarlău, A; Cucuruz, L

    1979-01-01

    Patients with scarlet fever were followed by clinical and laboratory investigation (bacteriologic and immunologic reactions, etc.), in relation with the early application, and the duration of penicillin therapy. The patients were also followed for a period of 30 days after discharge from the hospital. The results show a decrease in the number of early and late complications, as well as a reduction in the number of carriers of beta-haemolytic streptococcus in those patients in whom penicillin treatment was applied early, and when it was prolonged in the recovery period. The clinical and statistical data stress the pathologic morphology of scarlet fever, and the restructuration of complications when penicillin treatment is applied.

  8. Regional behaviour among late Neanderthal groups in Western Europe: a comparative assessment of late Middle Palaeolithic bifacial tool variability.

    Science.gov (United States)

    Ruebens, Karen

    2013-10-01

    Population dynamics between and within Pleistocene groups are vital to understanding wider behavioural processes like social transmission and cultural variation. The late Middle Palaeolithic (MIS 5d-3, ca. 115,000-35,000 BP [years before present]) permits a novel, data-driven assessment of these concepts through a unique record: bifacial tools made by classic Neanderthals. Previously, studies of late Middle Palaeolithic bifacial tools were hampered by a convoluted plethora of competing terms, types and regional entities. This paper presents a large-scale intercomparison of this tool type, and bridges typo-technological and spatio-temporal data from across Western Europe (Britain, Belgium, the Netherlands, France and Germany). Results indicate a high level of variation among individual bifacial tools and assemblages. Each bifacial tool concept is correlated with various methods of production, resulting in large degrees of morphological variation. Despite such variation, a distinct three-fold, macro-regional pattern was identified: the Mousterian of Acheulean Tradition (MTA) in the southwest dominated by handaxes, the Keilmessergruppen (KMG) in the northeast typified by backed and leaf-shaped bifacial tools, and, finally a new unit, the Mousterian with Bifacial Tools (MBT), geographically situated between these two major entities, and characterised by a wider variety of bifacial tools. Differing local conditions, such as raw material or function, are not sufficient to explain this observed macro-regional tripartite. Instead, the MTA and KMG can be viewed as two distinct cultural traditions, where the production of a specific bifacial tool concept was passed on over generations. Conversely, the MBT is interpreted as a border zone where highly mobile groups of Neanderthals from both the east (KMG) and west (MTA) interacted. Principally, this study presents an archaeological contribution to behavioural concepts such as regionality, culture, social transmission and

  9. Riparian woody vegetation history in the campos region, southeastern South America, during two time windows: late Pleistocene and late Holocene

    Science.gov (United States)

    Mourelle, Dominique; Prieto, Aldo R.; García-Rodríguez, Felipe

    2017-07-01

    A detailed palynological record from Laguna Formosa (northeastern campos region, 31°S; 54°W) documents the dynamic balance between grasslands and riparian forests during the late Pleistocene (14,570 to 13,500 cal yr BP) and late Holocene (3280 cal yr BP to the present). Modern pollen-vegetation relationships and the woody pollen dispersal capacity analyses were used to improve the vegetation reconstruction. Grasslands were regionally dominant throughout the record. However, at 14,570 cal yr BP hydrophilous taxa reflect the development of riparian hydrophilous shrublands along freshwater bodies, promoting the fixation of the riverbanks, maintaining shallow, calm and clear water conditions under a relatively wet and not so cool climate. This is the first evidence of woody riparian vegetation development along freshwater bodies for the lowlands of the northern campos during the late glacial period. At 3280 cal yr BP riparian forests consisted of both hydrophilous and mesophilous woody taxa. Since 2270 cal yr BP woody vegetation gradually increased, accompanied by the incorporation of other taxa by 940 cal yr BP, and achieving a composition similar to that of the contemporary time at ca. 540 cal yr BP. The increased woody vegetation since ca. 2270 cal yr BP, and the more frequent and intense flooding events between 1800 and 1200 cal yr BP, could be related to higher precipitation over La Plata Drainage Basin, related with the high ENSO amplitude. In addition, pollen from taxa that currently no longer develops in the study area suggests connections between southern Brazil and Uruguay, and between the campos and the Chaco phytogeographic province.

  10. Refsum Disease Presenting with a Late-Onset Leukodystrophy.

    Science.gov (United States)

    Bompaire, Flavie; Marcaud, Véronique; Trionnaire, Emmanuelle Le; Sedel, Frédéric; Levade, Thierry

    2015-01-01

    Adult Refsum disease is an autosomal recessive peroxisomal disorder characterized by phytanic acid storage. Clinical symptoms usually begin in late childhood before the age of 20. Typical clinical presentation includes nyctalopia caused by retinitis pigmentosa, and anosmia. After 10-15 years, deafness, cerebellar ataxia, polyneuropathy, ichthyosis, and cardiac arrhythmia can occur.We report the case of a very late-onset adult Refsum disease presenting with marked cognitive decline and severe leukoencephalopathy, without peripheral nervous system involvement. Brain MRI showed a leukoencephalopathy involving the periventricular white matter, subcortical area, and the brainstem with relative sparing of juxtacortical U fibers. This was associated with severe cortical and subcortical atrophy with ventricle dilatation. MR spectroscopy showed a marked increase in the choline/NAA ratio. Elevated plasma phytanic acid level was found, whereas plasma levels of pristanic and very long chain fatty acids were normal. The patient is homozygous for a previously undescribed PHYH frameshift mutation. Whether the very unusual phenotype is related to this peculiar mutation remains unclear.

  11. How to manage a late diagnosed Hirschsprung′s disease

    Directory of Open Access Journals (Sweden)

    Mohamed Ouladsaiad

    2016-01-01

    Full Text Available Background: How to manage a late diagnosed Hirschsprung′s disease (HD and how to avoid calibre discrepancy? Subjects and Methods: A retrospective study of all patients diagnosed with HD over 2 years in our hospital from January 2009 to December 2012. Data were analysed for clinical presentations, investigations, surgical procedures and post-operative outcome. Results: Fifteen patients, operated by one single surgeon, were included in this study. The mean age was 6 years (2-16 years. Patients had an ultra-short segment type in 4 cases, rectosigmoid type in 9 cases and descending colonic aganglionosis in 2 cases. Rectal wash out was effective in 12 patients. A blowhole transverse colostomy was performed in 2 patients. Twelve patients underwent one single stage endorectal pull-through. Anastomosis incongruence was avoided by a plication procedure never described before. The assessment of post-operative outcomes by the paediatric incontinence and constipation scoring system revealed a normal continence function in all our patients, but 3 patients suffered from soiling secondary to constipation. Conclusion: One single stage pull-through can be safe and effective in children with late diagnosed HD. Routine rectal washout is a good way to prepare the colon. In some cases, blowhole colostomy can be an option. Anastomosis incongruence is a challenge; we describe a plication procedure to avoid it.

  12. Late-onset psychosis and risedronate treatment for osteoporosis.

    Science.gov (United States)

    Hirschmann, Shmuel; Gibel, Anatoly; Tsvelikhovsky, Irena; Lisker, Alexander

    2015-04-01

    As women age and enter menopause, they are sometimes more susceptible than men to certain physical and mental disorders such as osteoporosis and late-onset schizophrenia. Risedronate (Actonel©) is a bisphosphonate used for the treatment of osteopenia. Early initiation of pharmacotherapy for osteopenia is recommended to prevent greater bone loss. The most common side effects of risedronate include fever and flu-like symptoms, hypocalcemia, bone and joint pain, peripheral edema, fatigue, change in bowel movements, osteonecrosis of the jaw, and atrial fibrillation. Though reports in the professional literature of psychotic reactions to risedronate are scant, there have been FDA reports as well as patient discussions of psychiatric side effects from this medication on popular websites. We report the case of M, age 59, who was treated with risedronate for osteoporosis, and was subsequently diagnosed with atypical psychosis after other organic causes were excluded. Though it is conceivable that age-related psychosocial and physical factors triggered late-onset schizophrenia, the temporal relationship between the termination of treatment with risedronate and the improvement in her mental state suggests that the risedronate might have triggered a psychotic reaction that resolved following cessation of treatment.

  13. Foraminiferal repopulation of the late Eocene Chesapeake Bay impact crater

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    Poag, C. Wylie

    2012-01-01

    The Chickahominy Formation is the initial postimpact deposit in the 85km-diameter Chesapeake Bay impact crater, which is centered under the town of Cape Charles, Virginia, USA. The formation comprises dominantly microfossil-rich, silty, marine clay, which accumulated during the final ~1.6myr of late Eocene time. At cored sites, the Chickahominy Formation is 16.8-93.7m thick, and fills a series of small troughs and subbasins, which subdivide the larger Chickahominy basin. Nine coreholes drilled through the Chickahominy Formation (five inside the crater, two near the crater margin, and two ~3km outside the crater) record the stratigraphic and paleoecologic succession of 301 indigenous species of benthic foraminifera, as well as associated planktonic foraminifera and bolboformids. Two hundred twenty of these benthic species are described herein, and illustrated with scanning electron photomicrographs. Absence of key planktonic foraminiferal and Bolboforma species in early Chickahominy sediments indicates that detrimental effects of the impact also disturbed the upper oceanic water column for at least 80-100kyr postimpact. After an average of ~73kyr of stressed, rapidly fluctuating paleoenvironments, which were destabilized by after-effects of the impact, most of the cored Chickahominy subbasins maintained stable, nutrient-rich, low-oxygen bottom waters and interstitial microhabitats for the remaining ~1.3myr of late Eocene time.

  14. Metaphors of Collecting in Late Nineteenth Century Paris

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    Valerie Mendelson

    2016-05-01

    Full Text Available At the same time that Aby Warburg was assembling his library and organizing his 'Bildatlas Mnemosyne', art critics and writers theorized late nineteenth-century collecting in Paris in metaphoric terms. Over and again, art collections were described as a bouquet, a conversation, a book, or indeed as a painting in and of itself put together by an ‘amateur’. By creating an ensemble, the amateur proposed a metaphorical mode of knowledge similar to that celebrated by Aby Warburg. This article considers the ways in which the arrangement and spaces of the late nineteenth-century amateurs, as seen in newspaper articles, sales catalogue essays and other texts and photographs, positioned the collector of paintings, but also of drawings and prints and rare books, in contradistinction to the development of the museum and proposed alternative modes of viewing and of knowing. The interdisciplinarity of Warburg’s focus on image, word, orientation and action is paralleled in many private collections.

  15. Late time cosmic acceleration from natural infrared cutoff?

    CERN Document Server

    Gorji, Mohammad Ali

    2016-01-01

    In this paper, inspired by the ultraviolet deformation of the Friedmann-Lema\\^{\\i}tre-Robertson-Walker geometry in loop quantum cosmology, we formulate an infrared-modified cosmological model. We obtain the associated deformed Friedmann and Raychaudhuri equations and we show that the late time cosmic acceleration can be addressed by the infrared corrections. As a particular example, we applied the setup to the case of matter dominated universe. This model has the same number of parameters as $\\Lambda$CDM, but a dynamical dark energy generates in the matter dominated era at the late time. According to our model, as the universe expands, the energy density of the cold dark matter dilutes and when the Hubble parameter approaches to its minimum, the infrared effects dominate such that the effective equation of state parameter smoothly changes from $w_{_{\\rm eff}}=0$ to $w_{_{\\rm eff}}=-2$. Interestingly and nontrivially, the unstable de Sitter phase with $w_{_{\\rm eff}}=-1$ is corresponding to $\\Omega_m=\\Omega_d ...

  16. Late Devonian conodonts and event stratigraphy in northwestern Algerian Sahara

    Science.gov (United States)

    Mahboubi, Abdessamed; Gatovsky, Yury

    2015-01-01

    Conodonts recovered from the Late Devonian South Marhouma section comprise 5 genera with 31 species (3 undetermined). The fauna establishes the presence of MN Zones 5, undifferentiated 6/7, 8/10 for the Middle Frasnian, the MN Zones 11, 12, 13 for the Upper Frasnian as well as the Early through Late triangularis Zones in the basal Famennian. The outcropping lithological succession is one of mostly nodular calcilutites alternating with numerous marly and shaly deposits, which, in the lower and upper part, comprise several dysoxic dark shale intervals. Among these the Upper Kellwasser horizon can be precisely dated and as such the presence of the terminal Frasnian Kellwasser Event is recognized for the first time in Algeria. Both the Middlesex and Rhinestreet Events cannot yet be precisely located, but supposedly occur among the dark shale horizons in the lower part of the section. However, their assignment to a precise level has so far not been established. Though poor in conodont abundance the South Marhouma section provides first evidence of the presence of several Montagne Noire conodont zones within the so far widely unstudied Frasnian of the Ougarta Chain. As such it is considered representative for the northwestern Algerian Saoura region.

  17. Late presentation of arrhythmogenic right ventricular cardiomyopathy: a case report

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    Papaioannou Georgios I

    2009-08-01

    Full Text Available Abstract Introduction Arrhythmogenic right ventricular cardiomyopathy is an inherited myocardial disease affecting predominantly young people and manifests as sustained ventricular tachycardia with left bundle branch block morphology, sudden death or isolated right or biventricular heart failure. However, its first manifestation as sustained ventricular tachycardia in older patients without preceding symptoms of heart failure is infrequent. To our knowledge, our patient is among the oldest reported in the literature presenting with ventricular tachycardia because of arrhythmogenic right ventricular cardiomyopathy without preceding symptoms of heart failure. Case presentation We present an unusual case of a very late presentation of a right ventricular cardiomyopathy in a 72-year-old white Caucasian man. The patient was admitted with symptoms of weakness, dizziness and chest discomfort for several hours. His electrocardiogram showed a wide-complex tachycardia with left bundle branch block morphology and left axis deviation. Because of continuing hemodynamic instability, the patient was cardioverted to sinus rhythm with a single 300 J shock. His post-cardioversion electrocardiogram, cardiac echocardiogram, coronary angiogram, magnetic resonance imaging and electrophysiological study confirmed the diagnosis of arrhythmogenic right ventricular cardiomyopathy. The patient was treated with an implantable cardioverter defibrillator and discharged on sotalol. Conclusion This case report demonstrates that arrhythmogenic right ventricular cardiomyopathy may have a very late presentation and this diagnosis should be considered as a potential cause of sustained ventricular tachycardia of right ventricular origin among the elderly and should be treated accordingly.

  18. Late photography, military landscapes, and the politics of memory

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    Simon Faulkner

    2014-10-01

    Full Text Available This essay considers the photographic genre of ‘late photography’ that has emerged roughly over the last two decades. Late photographs picture material remains left in the aftermath of events that often involve forms of violence. These photographs are usually high in detail, but formally simple, framing aftermath sites in ways that suggest the reservation of judgement and commentary upon the things they picture. This gives the impression that such photographs are intended to distance the spectator from the political meanings of the events or situations to which they refer. The discussion presented in the essay suggests that it is this apparent distancing from the political that opens up possibilities for the imaginative rethinking of how the past might function in relation to the politics of the present. The essay explores these concerns through the discussion of photographs by Simon Norfolk, Angus Boulton, Gilad Ophir and Roi Kuper, in relation to two historical and political contexts: the Cold War, considered briefly in relation to Boulton’s work and the Israeli-Palestinian conflict, considered more extensively in relation to the work of Norfolk, Ophir, and Kuper.

  19. Late Pleistocene and Holocene mammal extinctions on continental Africa

    Science.gov (United States)

    Faith, J. Tyler

    2014-01-01

    Understanding the cause of late Quaternary mammal extinctions is the subject of intense debate spanning the fields of archeology and paleontology. In the global context, the losses on continental Africa have received little attention and are poorly understood. This study aims to inspire new discussion of African extinctions through a review of the extinct species and the chronology and possible causes of those extinctions. There are at least 24 large mammal (> 5 kg) species known to have disappeared from continental Africa during the late Pleistocene or Holocene, indicating a much greater taxonomic breadth than previously recognized. Among the better sampled taxa, these losses are restricted to the terminal Pleistocene and early Holocene, between 13,000 and 6000 yrs ago. The African extinctions preferentially affected species that are grazers or prefer grasslands. Where good terrestrial paleoenvironmental records are present, extinctions are associated with changes in the availability, productivity, or structure of grassland habitats, suggesting that environmental changes played a decisive role in the losses. In the broader evolutionary context, these extinctions represent recent examples of selective taxonomic winnowing characterized by the loss of grassland specialists and the establishment of large mammal communities composed of more ecologically flexible taxa over the last million years. There is little reason to believe that humans played an important role in African extinctions.

  20. Late Cretaceous fluvial systems and inferred tectonic history, central Utah

    Energy Technology Data Exchange (ETDEWEB)

    Lawton, T.F.

    1983-08-01

    Upper Campanian nonmarine sedimentary rocks exposed between the Wasatch Plateau and the Green River in central Utah record a tectonic transition from thin-skinned deformation in the thrust belt to basement-cored uplift in the foreland region. Sandstones within the section consist of two distinct compositional suites, a lower quartzose petrofacies and an upper lithic petrofacies. The volcanic lithic grains of the Farrer and Tuscher Formations were derived from more distal arc sources to the southwest, and transported through the thrust belt somewhere west of the Kaiparowits region, where time-equivalent sedimentary rocks are also rich in volcanic lithic fragments. Disappearance of volcanic lithics and appearance of pebbles at the top of the Tuscher Formation is interpreted to reflect a latest Campanian reorganization of drainage patterns that marked initial growth of the San Rafael swell and similar basement uplifts to the south of the swell. Contemporaneous fluvial systems that deposited the uppermost part of the Price River Formation in the Wasatch Plateau were apparently unaffected by the uplift and continued to flow northeast. Depositional patterns thus indicate that initial growth of the San Rafael swell was probably concurrent with late deformation in the thrust belt. Depositional onlap across the Mesaverde Group by a largely post-tectonic assemblage of fluvial and lacustrine strata (North Horn Formation) indicates a minimum late Paleocene age for growth of the San Rafael swell and deformation within the thrust belt.