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Sample records for nodular heterotopia case

  1. A Case with Bilateral Periventricular Nodular Heterotopia Diagnosed as Depression

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    Melek Kandemir

    2010-06-01

    Full Text Available Periventricular nodular heterotopia is a form of neuronal migration abnormality. Periventricular nodular heterotopia can easily be recognized by cranial magnetic resonance imaging. The most common clinical appearance is epileptic seizures. In some cases, symptoms are accompanied with psychiatric complaints. In this article, we report a 33-year-old female with complaints of left-sided paresthesia induced by emotional stress. She had been followed at an outpatient psychiatry clinic for about 10 years with the diagnosis of somatization disorder. Her electroencephalography recordings -awake as well as during sleep- were found to be normal. The cranial magnetic resonance imaging showed bilateral periventricular nodular heterotopia. Her seizures were controlled with carbamazepine treatment. Partial epileptic seizures might also be observed, even though the cerebral heterotopic lesions are bilateral. When a history is obtained from a patient with somatoform complaints, it should be kept in mind that these symptoms might be seizures, and the patient should be questioned accordingly.

  2. De Morsier syndrome associated with periventricular nodular heterotopia: case reporte Síndrome de De Morsier associada a heterotopia nodular periventricular: relato de caso

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    Mônica Jaques Spinosa

    2007-09-01

    Full Text Available INTRODUCTION: Septo-optic dysplasia (De Morsier syndrome is defined as the association between optic nerve hypoplasia, midline central nervous system malformations and pituitary dysfunction. CASE REPORT: Third child born to nonconsanguineous parents, female, adequate pre-natal medical care, cesarean term delivery due to breech presentation, Apgar score 3 at the first minute and 8 at 5 minutes, symptomatic hypoglycemia at 18 hours. Neurological follow-up identified a delay in acquisition of motor and language developmental milestones. Epileptic generalized seizures began at 12 months and were controlled with phenobarbital. EEG was normal. MRI revealed agenesis of the pituitary stalk, hypoplasia of the optic chiasm and periventricular nodular heterotopia. Ophthalmologic evaluation showed bilateral optic disk hypoplasia. Endocrine function laboratory tests revealed primary hypothyroidism and hyperprolactinemia. CONCLUSION: The relevance of this case report relies on its uniqueness, since periventricular heterotopia had not been described in association with septo-optic dysplasia until 2006.INTRODUÇÃO: Displasia septo-óptica (síndrome de De Morsier é definida como a associação entre hipoplasia do nervo óptico, malformações de linha média do sistema nervoso central e disfunção pituitária. RELATO DE CASO: Terceiro filho, pais não consangüíneos, sexo feminino, pré-natal adequado, parto cesário a termo por apresentação pélvica, Apgar 3 no primeiro minuto e 8 no quinto minuto, hipoglicemia sintomática com 18 horas de vida. Durante o acompanhamento neurológico identificou-se atraso na aquisição dos marcos de desenvolvimento motor e linguagem. Crises epilépticas generalizadas iniciaram com 12 meses de vida sendo controladas com fenobarbital. EEG era normal. Ressonância magnética revelou agenesia de haste pituitária, hipoplasia de quiasma óptico e heterotopia nodular periventricular. Avaliação oftalmológica demonstrou

  3. Periventricular Nodular Heterotopia, Surgical Goal in Drug-Resistant Epilepsy

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    Fernando Velandia-Hurtado

    2014-09-01

    Full Text Available Introduction: Neuronal heterotopia is a migration disorder in which these cells do not complete their movement toward the cerebral cortex. Periventricular nodular heterotopia is the most frequently reported form, characterized by neuronal conglomerates adjacent to the lateral ventricles walls. About 90 % of patients with this condition suffer epilepsy at some point in their lives and the major proportion of them will be resistant to pharmacologic treatment. This makes an appropriate diagnostic approach necessary in order to determine which patients would benefit from surgical resection of the lesion, which in most cases offers a high rate of crisis control. Development: This article presents a review of the most important topics approached from the practice of periventricular nodular heterotopia pathophysiology, clinical features, diagnosis and therapy. It is aimed at exploring the role of this condition as a cause of intractable epilepsy. Conclusion: Pharmacologic treatment for resistant epilepsy will have a severe impact on patient’s quality of life. Periventricular nodular heterotopia is frequently associated to this condition, which must be successfully approached by the medical team attempting to an opportune diagnosis and defining which patients would benefit from surgical management. This positively impacts the quality of life of these patients and their caregivers.

  4. Quantitative assessment of corpus callosum morphology in periventricular nodular heterotopia.

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    Pardoe, Heath R; Mandelstam, Simone A; Hiess, Rebecca Kucharsky; Kuzniecky, Ruben I; Jackson, Graeme D

    2015-01-01

    We investigated systematic differences in corpus callosum morphology in periventricular nodular heterotopia (PVNH). Differences in corpus callosum mid-sagittal area and subregional area changes were measured using an automated software-based method. Heterotopic gray matter deposits were automatically labeled and compared with corpus callosum changes. The spatial pattern of corpus callosum changes were interpreted in the context of the characteristic anterior-posterior development of the corpus callosum in healthy individuals. Individuals with periventricular nodular heterotopia were imaged at the Melbourne Brain Center or as part of the multi-site Epilepsy Phenome Genome project. Whole brain T1 weighted MRI was acquired in cases (n=48) and controls (n=663). The corpus callosum was segmented on the mid-sagittal plane using the software "yuki". Heterotopic gray matter and intracranial brain volume was measured using Freesurfer. Differences in corpus callosum area and subregional areas were assessed, as well as the relationship between corpus callosum area and heterotopic GM volume. The anterior-posterior distribution of corpus callosum changes and heterotopic GM nodules were quantified using a novel metric and compared with each other. Corpus callosum area was reduced by 14% in PVNH (p=1.59×10(-9)). The magnitude of the effect was least in the genu (7% reduction) and greatest in the isthmus and splenium (26% reduction). Individuals with higher heterotopic GM volume had a smaller corpus callosum. Heterotopic GM volume was highest in posterior brain regions, however there was no linear relationship between the anterior-posterior position of corpus callosum changes and PVNH nodules. Reduced corpus callosum area is strongly associated with PVNH, and is probably associated with abnormal brain development in this neurological disorder. The primarily posterior corpus callosum changes may inform our understanding of the etiology of PVNH. Our results suggest that

  5. Periventricular nodular heterotopia in Smith-Magenis syndrome.

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    Capra, Valeria; Biancheri, Roberta; Morana, Giovanni; Striano, Pasquale; Novara, Francesca; Ferrero, Giovanni Battista; Boeri, Luca; Celle, Maria Elena; Mancardi, Maria Margherita; Zuffardi, Orsetta; Parrini, Elena; Guerrini, Renzo

    2014-12-01

    Smith-Magenis syndrome (SMS) is caused by an interstitial microdeletion of chromosome 17p11.2. A few patients with the typical SMS phenotype have RAI1 gene mutations. The syndrome is characterized by minor craniofacial anomalies, short stature, sleep disturbances, behavioural and neurocognitive abnormalities, as well as variable multisystemic manifestations. Periventricular nodular heterotopia (PNH) is a genetically heterogeneous neuronal migration disorder characterized by subependymal heterotopic nodules, and is variably associated with other brain malformations, epileptic seizures and intellectual disability. Here we report on two patients harboring deletions of the 17p11.2 region in whom the SMS typical phenotype was associated with bilateral PNH. Our observations expand the spectrum of chromosomal rearrangements associated with PNH and indicate that abnormal neuronal migration may contribute to the neurocognitive phenotype of SMS.

  6. 47 patients with FLNA associated periventricular nodular heterotopia.

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    Lange, Max; Kasper, Burkhard; Bohring, Axel; Rutsch, Frank; Kluger, Gerhard; Hoffjan, Sabine; Spranger, Stephanie; Behnecke, Anne; Ferbert, Andreas; Hahn, Andreas; Oehl-Jaschkowitz, Barbara; Graul-Neumann, Luitgard; Diepold, Katharina; Schreyer, Isolde; Bernhard, Matthias K; Mueller, Franziska; Siebers-Renelt, Ulrike; Beleza-Meireles, Ana; Uyanik, Goekhan; Janssens, Sandra; Boltshauser, Eugen; Winkler, Juergen; Schuierer, Gerhard; Hehr, Ute

    2015-10-15

    Heterozygous loss of function mutations within the Filamin A gene in Xq28 are the most frequent cause of bilateral neuronal periventricular nodular heterotopia (PVNH). Most affected females are reported to initially present with difficult to treat seizures at variable age of onset. Psychomotor development and cognition may be normal or mildly to moderately impaired. Distinct associated extracerebral findings have been observed and may help to establish the diagnosis including patent ductus arteriosus Botalli, progressive dystrophic cardiac valve disease and aortic dissection, chronic obstructive lung disease or chronic constipation. Genotype-phenotype correlations could not yet be established. Sanger sequencing and MLPA was performed for a large cohort of 47 patients with Filamin A associated PVNH (age range 1 to 65 years). For 34 patients more detailed clinical information was available from a structured questionnaire and medical charts on family history, development, epileptologic findings, neurological examination, cognition and associated clinical findings. Available detailed cerebral MR imaging was assessed for 20 patients. Thirty-nine different FLNA mutations were observed, they are mainly truncating (37/39) and distributed throughout the entire coding region. No obvious correlation between the number and extend of PVNH and the severity of the individual clinical manifestation was observed. 10 of the mutation carriers so far are without seizures at a median age of 19.7 years. 22 of 24 patients with available educational data were able to attend regular school and obtain professional education according to age. We report the clinical and mutation spectrum as well as MR imaging for a large cohort of 47 patients with Filamin A associated PVNH including two adult males. Our data are reassuring in regard to psychomotor and cognitive development, which is within normal range for the majority of patients. However, a concerning median diagnostic latency of 17 to 20

  7. HETEROTOPIA

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    Dinesh

    2013-11-01

    Full Text Available ABSTRACT: Cortical dysplasias i.e. cortical developmental disorders are emerging as important and common causes of epilepsy with the advent of modern high - resolution MR scanning. Among these, heterotopias are the most common developmental disorders in patients with epilepsy. 1 Heterotopia is the name given to focal collections of ectopic neurons in the cerebral hemispheres, i.e. normal cells present in an abnormal location. It is believed to be the result of prematurely arrested radial neuronal migr ation. Here we are presenting a rare case of an adult male with epilepsy, found to be having heterotropias on MR scanning

  8. Periventricular nodular heterotopia, frontonasal encephalocele, corpus callosal dysgenesis and arachnoid cyst: A constellation of abnormalities in a child with epilepsy.

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    Krishnan, Prasad; Chattopadhyay, Arijit; Saha, Manash

    2014-01-01

    A 7-year-old male child presented with poorly controlled generalized tonic-clonic seizures. On examination, he was mentally retarded, deaf and had a swelling at the root on the nose. Computed tomography scan done previously revealed a left temporal arachnoid cyst (AC) due to which he was referred for surgery. However, magnetic resonance imaging revealed a constellation of abnormalities - all of which could be responsible for his seizures. The combination of periventricular nodular heterotopias with encepaholcele is rarely described in the literature, and more infrequently so its combination with AC and callosal dysgenesis - the Chudley-Mccullough syndrome. We describe the case and review relevant literature on this subject.

  9. Periventricular nodular heterotopia and bilateral intraventricular xanthogranulomas in 22q11.2 deletion syndrome

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    Moogeh Baharnoori

    2017-09-01

    Full Text Available 22q11.2 deletion syndrome (22q11DS is the most common pathogenic copy number variant in humans. Neuropsychiatric phenotypes, including schizophrenia, are prominent. Imaging studies of individuals with this syndrome show a variety of abnormalities that may indicate abnormal neuronal migration. Here we present the neuroimaging and neuropathologic features of a 22q11DS patient with bilateral periventricular nodular heterotopias (PNH and intraventricular xanthogranulomas that were identified by post-mortem examination.

  10. Bilateral Periventricular Nodular Heterotopia and Lissencephaly in an Infant with Unbalanced t(12;17)(q24.31; p13.3) Translocation

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    Grosso, Salvatore; Fichera, Marco; Galesi, Ornella; Luciano, Daniela; Pucci, Lucia; Giardini, Francesca; Berardi, Rosario; Balestri, Paolo

    2008-01-01

    Periventricular nodular heterotopia and Miller-Dieker syndrome are two different disorders of brain development. Miller-Dieker syndrome exhibits classical lissencephaly and is related to defects in the lissencephaly gene ("LIS1"). Periventricular nodular heterotopia is characterized by aggregates of grey matter adjacent to the lateral ventricle…

  11. Periventricular nodular heterotopia, frontonasal encephalocele, corpus callosal dysgenesis and arachnoid cyst: A constellation of abnormalities in a child with epilepsy

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    Prasad Krishnan

    2014-01-01

    Full Text Available A 7-year-old male child presented with poorly controlled generalized tonic-clonic seizures. On examination, he was mentally retarded, deaf and had a swelling at the root on the nose. Computed tomography scan done previously revealed a left temporal arachnoid cyst (AC due to which he was referred for surgery. However, magnetic resonance imaging revealed a constellation of abnormalities - all of which could be responsible for his seizures. The combination of periventricular nodular heterotopias with encepaholcele is rarely described in the literature, and more infrequently so its combination with AC and callosal dysgenesis - the Chudley-Mccullough syndrome. We describe the case and review relevant literature on this subject.

  12. Cerebro-cerebellar functional connectivity profile of an epilepsy patient with periventricular nodular heterotopia.

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    Emiliano, Santarnecchi; Giampaolo, Vatti; Daniela, Marino; Nicola, Polizzotto; Alfonso, Cerase; Raffaele, Rocchi; Alessandro, Rossi

    2012-09-01

    Periventricular nodular heterotopia (PNH) is a rare malformation of cortical development often associated with drug resistant focal onset epilepsy. The link between nodules and neocortex have been demonstrated with depth electrodes investigations showing that seizures may arise from both structures. In the last years fMRI resting-state (fMRI-RS) have received a surge in interest due to its capability to track non-invasively physiological and pathological relevant differences in brain network organization. We performed a cerebro-cerebellar voxel-wise and region-of-interest resting state fMRI (RS-fMRI) functional connectivity analysis in a seizure-free epilepsy patient with a PNH in the right temporal horn. Our finding confirms a spontaneous synchronization between PNH and its surrounding cortex, specifically in the inferior temporal, fusiform and occipital gyrus. We also found a significant connectivity with bilateral cerebellum, more intense and widespread on the PNH cerebellar contralateral lobule. RS-fMRI confirmed its potential as a promising tool for non-invasive mapping of cortical and subcortical brain functional organization.

  13. Periventricular nodular and subcortical neuronal heterotopia in adult epileptic patients Heterotopía neuronal nodular y subcortical en pacientes adultos con epilepsia

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    Damián E. Consalvo

    2006-04-01

    Full Text Available Developmental malformations are brain abnormalities that occur during embryogenesis. Neuronal migration disorders, including heterotopic lesions, constitute one type of such abnormalities. The aim of the study was to compare the epileptic clinical patterns of patients with periventricular nodular heterotopia (PNH (G1 with those affected by subcortical heterotopia (SCH (G2 looking for differences between both groups which, eventually, might suggest the type of the underlying malformation. The variables studied in both groups were: type of the heterotopia depicted on MRI studies, sex, age, age at seizure onset, annual seizure frequency, localization of the ictal symptomatogenic zone, characteristics of the EEG, other associated anomalies on the magnetic resonance images (MRI besides the heterotopia, and response to treatment. The only difference found between both groups was the type of heterotopia as shown by MRI studies. The other assessed variables did not significantly (p>0.05 differ between groups. No differences in the clinical features characterizing epilepsy could be found in patients with PNH or SCH, being the images the only tool able to differentiate them.Las malformaciones de la corteza cerebral son un grupo de entidades que se producen durante las etapas del desarrollo embrionario y cuya manifestación clínica puede ser la epilepsia. Estas malformaciones pueden ser diagnosticadas in vivo a través de las imágenes por resonancia magnética (IRM. Un subtipo particular de éstas lo constituyen los trastornos en la migración neuronal, dentro de los cuales se ubican las heterotopías (HT. El objetivo del estudio fue comparar enfermos portadores de HT periventriculares (G1 con aquellos portadores de HT subcorticales (G2. Se analizaron las variables sexo, edad y edad de inicio de la epilepsia (EI en años, antecedentes familiares (AF o prenatales (AP, frecuencia anual de crisis (FAC y características semiológicas de las crisis

  14. Unilateral nodular adrenal hyperplasia: Case series

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    A.F. Kotb

    2016-07-26

    Jul 26, 2016 ... with hyperaldosteronism or Cushing syndrome. Case series: We ... Pathological examination confirmed the diagnosis of nodular hyperplasia. ... Theirpatients were managed by unilateral adrenalectomy and this management.

  15. A Case of Nasal Glial Heterotopia in an Adult

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    Akira Hagiwara

    2014-01-01

    Full Text Available We report a rare case of nasal glial heterotopia in an adult. After the surgery, frontal lobe cerebral hemorrhage developed. A 58-year-old man had unilateral nasal obstruction that progressed for one year. He had been treated for hypertension, chronic heart failure, and cerebral infarction with aspirin and warfarin. A computed tomography scan showed that the tumor occupied the right nasal cavity and the sinuses with small defect in the cribriform plate. The tumor was removed totally with endoscopy. After the operation, the patient developed convulsions and frontal lobe cerebral hemorrhage. The hemorrhage site was located near a defect in the cribriform plate. Nasal glial heterotopia is a rare developmental abnormality, particularly rare in adult. Only few cases were reported. We could not find any report of adult nasal glial heterotopias that developed cerebral hemorrhage as a complication of the surgery.

  16. Massive nodular melanoma scalp: a case report

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    A. Bhagya Lakshmi

    2015-04-01

    Full Text Available Melanoma is responsible for 1% to 2% of all cancer deaths around the world. Nodular melanoma often carries a poor prognosis because of no prodromal radial growth phase, early distant metastasis and significant tumour volume. We present a case of nodular melanoma measuring 20x10x8 cm in 28 year old tribal women. [Int J Res Med Sci 2015; 3(4.000: 1002-1005

  17. Double Cortex Syndrome (Subcortical Band Heterotopia: A Case Report

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    Ali Akbar MOMEN

    2015-06-01

    Full Text Available AbstractObjectiveApproximately 5–10% of preschool age children are considered developmentally disabled. Brain Magnetic Resonance Imaging (MRI plays a key role in the diagnostic evaluation in these children. Many congenital or acquired brain anomalies are revealed with MRIs. Although the majority of these abnormalities are sporadic but patients with subcortical band heterotopia or double cortex syndrome have sex-linked inheritance. We are going to present the first case in Iran from Ahvaz city, which was presented with status epilepticus associated with developmental delay and finally diagnosed as double cortex syndrome, because band heterotopia cases especially for continuous or generalized form is rare.A 4.5-year-old developmentally delayed girl was admitted for generalized tonic clonic seizure attack of 1 hr, upward gaze, locked mouth, and urinary incontinence (status epilepticus in the child neurology ward. She had a history of recurrent seizures that started as febrile seizures since she was 12 months of age and had frequent admissions for having recurrent seizure attacks. She was the only child of consanguineous parents with negative family history of any neurologic problems. She was a product of uneventful term pregnancy, vaginal delivery with a low Apgar score at birth who was admitted for six days in the neonatal ward for hypotonia and cyanosis. At 4.5 years of age, she had HC: 45cm (<3% Length: 102 cm (25–75%, and BW: 18kg (75%.She was able to sit, walk with support, speak a few words, and communicate with others. A physical exam was unremarkable. Lab data including CBC, blood biochemical, and urinalysis results were all within normal limits, but the electroencephalography (EEG revealed generalized poly spike-wave discharges. A brain MRI showed corpus callosal dysplasia, generalized band heterotopia, and polymicrogyria. She was discharged home with oral valproate and regular outpatient follow-ups.In the diagnostic evaluation of

  18. Hemorrhagc focal nodular hyperplasia in young men: A case report

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    Lee, Jin Hyun; Kwon, Hee Jin; Cho, Jin Han; Oh, Jong Yeong; Nam, Kyung Jin; Roh, Young Hoon; Jeong, Jin Sook [College of Medicine, Dong-A University, Busan (Korea, Republic of)

    2014-04-15

    In general, focal nodular hyperplasia is a hepatic lesion that most frequently affects the healthy women of reproductive age. Focal nodular hyperplasia lesions have a benign natural course; the majority of the cases remain asymptomatic and complications are rare. Spontaneous hemorrhage of focal nodular hyperplasia is a rare disease, and the hemorrhage in young men is even more uncommon. We report a rare case of spontaneous hemorrhage of focal nodular hyperplasia in a 19-year-old man.

  19. NASAL GLIAL HETEROTOPIA-A SERIES OF FOUR CASES

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    Ramani

    2013-05-01

    Full Text Available ABSTRACT: Glial heterotopias are rare, benign, congenital, mi dline, non- teratomatous extra cranial glial tissues. They may masquerade as encep halocoele or dermoid cyst and mostly present in and around the nose. Clinically, these masses are firm and incompressibl e. Histologically, they are made up of astrocytes and neuroglial cells, emb edded in fibrous and vascular connective tissue. Here in, we present 4 cases of nasal glial heteroto pias. The first case was an 8 month old boy who presented with broadening of nose since birth. The second case was of 6 months old girl who presented with a soft tissue swelling over the root of the nose. The third case was of a 2 months old boy who presented with a soft tissue swelling over the nasolabial fold. The fourth case was a 5 month old boy with mass in left nostril. The radiol ogical and histological features along with differential diagnosis are discussed. These cases a re presented because of their rarity.

  20. Nodular Epiescleritis Granulomatous Canine. Case Report

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    Camilo Guarín Patarroyo

    2011-12-01

    Full Text Available Granulomatous epiescleritis nodular disease in canines is a very unusual presentation that affects or external fibrous tunic of the eyeball and conjunctiva, which was an increase similar to a unilateral or bilateral tumor. Suspected immune-mediated disease due to lack of identification of an etiologic agent and the response to treatment with immunosuppressive drugs (Couto, 1992. The ideal therapy is the application of steroids via intralesional, topical or systemic, or other immunosuppressants such as cyclosporine and azathioprine; it is still advisable to apply antibiotic is the ideal combination of tetracycline and neomycin (Gilger & Whitley, 1999. The diagnostic method of episcleritis is made by histopathology, which is evident in changes similar to chronic granulomatous inflammation. Are claiming a racial bias in Alsatian, Shepherd Collie Shetland Shepherd, Coker Spaniel, Rottweiler and Labrador Retriever (Gough & Thomas, 2004. The following case is a report of a nodular epiescleritis affecting the cornea, sclera, and the corneoscleral limbus, which describes the diagnosis, signology and treatment.

  1. Subependymal periventricular heterotopias in a patient with ehlers-danlos syndrome: a new case.

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    Savasta, Salvatore; Crispino, Mario; Valli, Maurizia; Calligaro, Alberto; Zambelloni, Cesare; Poggiani, Carlo

    2007-03-01

    Ehlers-Danlos syndrome is a complex hereditary connective tissue disorder that is characterized by abnormalities of the skin and joints and visceral and neurological manifestations. At present, at least 11 forms are recognized on the basis of their clinical characteristics, methods of transmission, and biochemical defect. The neurologic manifestations include cerebrovascular disease, peripheral neuropathy, plexopathy, periventricular subependymal heterotopias, and epilepsy. Previously, 2 females were reported to be affected with subependimal periventricular heterotopias and Ehlers-Danlos syndrome type 1. The authors report a new case of a 12-year-old girl with similar clinical and neuroradiological features.

  2. The application of magnetic source imaging in epileptic with MR1 negative nodular gray natter heterotopia%磁源性影像在MRI阴性的结节状灰质异位伴癫痫发作患者中的应用

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    吴杰; 孙吉林; 吴晶; 贾秀川

    2011-01-01

    目的:探讨磁源性影像(MSI)在MRI阴性的结节状灰质异位伴癫痫发作患者中的应用价值.方法:对6例病理证实为结节状灰质异位的MRI阴性的患者行MSI检查,进行发作间期神经元癫痫样放电的定位.结果:患者中5例癫痫灶位于颞叶,此5例行前颞叶及海马切除;1例癫痫灶位于右侧额顶中央区,行右额顶癫痫灶切除.所有6例患者均为结节状灰质异位,其中4例伴有局灶性脑发育不良或微发育不良.4例伴有海马硬化.随访结果中依据南京军区总医院评估标准,疗效满意者5例(5/6).显著改善者1例(1/6).结论:MSI可提示灰质异位伴发癫痫患者的癫痫灶定位,是术前无创伤性定位的有效手段,通过手术治疗可取得良好的效果.%Objective:To evaluate the value of magnetic source imaging (MSI) in epileptic with MRI negative nodular gray matter heterotopial. Methods: 6 epileptic patients with MRI negative nodular gray matter heterotopia had MSI examination for localizing the epileptic focus. Results:The epileptic foci were localized at temporal lobe in 5 cases, che anterior temporal lobe and hippocampus were resected. The epileptic focus was localized at central zone of right frontoparietal lobe and resected in 1 case. All of the 6 patients were nodular gray matter heterotopia pathologically, together with focal cortical dyspla-sia or microdysplasia in 4 cases, hippocampal sclerosis in 4 cases. According to the assessing standard of Nanjing general military hospital, the result of follow up were satisfied in 5 cases and marked improved in 1 case. Conclusion: MSI can prompt the epileptic focus in patients with gray matter heterotopia. It is an effective location method preoperatively and the patients can achieve good outcome by surgery.

  3. Intraductal Papillary Mucinous Neoplasm Occurring In Pancreatic Heterotopia Of The Duodenum: Two Cases And A Review Of The Literature

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    Sarah M Choi

    2008-09-01

    Full Text Available Context Heterotopic pancreas is usually an incidental finding during pathologic evaluation of gastrointestinal polyps or lesions encoun-tered during endoscopy for nonspecific symptoms or unrelated conditions. However, the same neoplastic processes that occur in normal pancreas also can occur in pancreatic heterotopias. Case report We report two cases of intraductal papillary mucinous neoplasms arising in pancreatic heterotopia within the duodenum of two patients. These cases are among the first reports of neoplasia occurring in pancre-atic heterotopia of the duodenum. Both patients are being managed expectantly, as there is currently no consensus regarding the proper follow up in these cases, particularly those that have been incompletely excised. Conclusion These cases highlight the potential for neo-plasia in pancreatic heterotopia and emphasize the importance of careful evaluation of these lesions. Close clinical follow up and possible excision may be warranted in patients with concerning pathologic or clinical findings.

  4. Nodular scabies: a classical case report in an adolescent boy.

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    Ramachandra Reddy, Damodara; Ramachandra Reddy, Prathap

    2015-09-01

    This case report presents a classical case of nodular scabies in a 12 year boy who complained of itching for 20-21 days before presentation to the hospital. Application of Betnovate ointment (Betamethasone valerate 0.1 %) before presentation to the hospital had provided only 2-3 days of relief from itching. Dermatological examination revealed skin colored to erythematous papule of 3-4 mm on the body with predilection for web space of fingers and flexural areas and nodules on the scrotum and groin. Based on this, clinical diagnosis of scabies with nodular scabies was made on the child. The scraping obtained from the web-space of the child showed mite under the light microscope, which confirms the diagnosis. Treatment with topical permethrin 5 % lotion resulted in 50-70 % subsidence of itching within a day, and improvement in impetigo lesions of his father in 5 days. However, the scrotal and groin nodular lesion of the child persisted with severe itching. Treatment with topical steroid and tacrolimus 0.1 % ointment did not show much improvement. Intralesional injection of triamcinolone (5 mg/ml) on the nodule resulted in 30-40 % subsidence in itching and 50-60 % reduction in the size of the lesion over 2-3 weeks.

  5. Idiopathic nodular glomerulosclerosis: Report of two cases and review of literature

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    S Chandragiri

    2016-01-01

    Full Text Available Nodular glomerulosclerosis, a pathological finding characterized by areas of marked mesangial expansion with accentuated glomerular nodularity can be seen in a number of conditions including diabetic nephropathy, amyloidosis, light chain deposition disease, fibrillary and immunotactoid glomerulopathy, collagen type III disease, nodular membranoproliferative glomerulonephritis, and Takayasu′s arteritis. Idiopathic nodular glomerulosclerosis is a diagnosis of exclusion and is reported in patients with hypertension, smoking, chronic obstructive pulmonary disease, obesity, metabolic syndrome, etc. We report two cases of idiopathic nodular glomerulosclerosis, one in obese hypertensive male and the other in nonhypertensive, nonobese female patient.

  6. Glial heterotopia in head and neck, single center experience of 5 cases

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    Ramyapriyadarshini Arikeri

    2016-07-01

    Conclusions: Glial Heterotopias of head and neck are more common in the nasal cavity. Middle ear Glial heterotopias are very rare. Clinical and radiological findings along with histopathology and immuno-histochemistry are essential in diagnosing these lesions. [Int J Res Med Sci 2016; 4(7.000: 3009-3012

  7. Heterotopia and cultural activism – the case of Hamburg’s Gängeviertel

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    Helten, Michael

    2015-09-01

    Full Text Available This paper investigates the Gängeviertel movement in Hamburg and the place which the activists have (reconstructed since its occupation in 2009 through the lens of Foucault’s (1986 concept of heterotopia. In the light of the recent debate about the role of cultural activism in the contemporary struggle about urban development, it explores the question which spatial practices and structures have evolved as oppositional to or in alignment with the neoliberal status quo of Hamburg’s spatial policy. Based on a qualitative case-study approach, the research was carried out in 2013. By using the analytical categories built environment, social practice and neoliberal normalisation, it illustrates that the Gängeviertel is characterised by practices that position it simultaneously both in- and outside of the neoliberal logic.

  8. A case of hepatocellular carcinoma arising within large focal nodular hyperplasia with review of the literature

    Institute of Scientific and Technical Information of China (English)

    Theodoros Petsas; Athanassios Tsamandas; Irene Tsota; Dionisios Karavias; Chrysoula Karatza; Vassilios Vassiliou; Dimitrios Kardamakis

    2006-01-01

    Focal nodular hyperplasia (FNH) is a relatively rare benign hepatic tumor, usually presenting as a solitary lesion; however, multiple localizations have also been described. The association of FNH with other hepatic lesions, such as adenomas and haemangiomas has been reported by various authors. We herein report a case of a hepatocellular carcinoma arising within a large focal nodular hyperplasia, in a young female patient.

  9. Nodular Hyperplasia Arising from the Lateral Aberrant Thyroid Tissue: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Min Hye; Park, Jeong Seon; Lee, Young Jun [Dept. of Radiology, Hanyang University College of Medicine, Hanyang University Hospital, Seoul (Korea, Republic of)

    2012-06-15

    The presence of aberrant thyroid tissue in the lateral neck is very rare. In addition, nodular hyperplasia in ectopic thyroid has rarely been reported. Due to the unusual location, the presence of lateral aberrant thyroid tissue could be misdiagnosed as a lymphadenopathy, neurogenic tumor, etc. We report on a case of nodular hyperplasia arising from the right lateral aberrant thyroid tissue.

  10. Thyroid hemiagenesis associated with retrosternal nodular goiter: a case report.

    Directory of Open Access Journals (Sweden)

    Turkay Kirdak

    2014-09-01

    Full Text Available Thyroid hemiagenesis can be associated with various thyroid pathologies such as papillary thyroid cancer or nodular goiter. However, we did not encounter any publication in the literature in which hemiagenesis could be observed together with retrosternal goiter. In this report, a thyroid hemiagenesis associated with a benign nodular goiter extending retrosternally is reported. A 59-year-old male patient presented to the surgery clinic because of swelling in the neck. A mass was observed in the right thyroid lobe extending to the retrosternal region. On ultrasonography, a nodule in the right thyroid lobe measuring 63 mm was determined, which was extended retrosternally. However, the left lobe of the thyroid could not be visualized. Scintigraphy and Computerized Tomography confirmed hemiagenesis. Total thyroidectomy was performed without sternotomy. In conclusion, thyroid hemiagenesis can be associated with a retrosternally located nodular goiter.

  11. Variable Ki67 proliferative index in 65 cases of nodular fasciitis, compared with fibrosarcoma and fibromatosis.

    Science.gov (United States)

    Lin, Xu-Yong; Wang, Liang; Zhang, Yong; Dai, Shun-Dong; Wang, En-Hua

    2013-03-26

    Nodular fasciitis is the most common pseudosarcomatous lesion of soft tissue. Ki67 was considered as a useful marker for distinguishing some benign and malignant lesions. To study the usefulness of Ki67 in diagnosis of nodular fasciitis, the expression of Ki67 was examined by using immunostaining in 65 nodular fasciitis specimens, 15 desmoid fibromatosis specimens and 20 fibrosarcoma specimens. The results showed that there was a variable Ki67 index in all 65 cases of nodular fasciitis, and the mean labeling index was 23.71±15.01%. In majority (70.77%) of all cases,the index was ranged from 10% to 50%, in 6.15% (4/65) of cases the higher Ki67 index (over 50%) could be seen. The Ki67 proliferative index was closely related to duration of lesion, but not to age distribution, lesion size, sites of lesions and gender. Moreover, the mean proliferative index in desmoid fibromatosis and fibrosarcoma was 3.20±1.26% and 26.15±3.30% respectively. The mean Ki67 index of nodular fasciitis was not significantly lower than fibrosarcoma, but higher than desmoid fibromatosis. The variable and high Ki67 index in nodular fasciitis may pose a diagnostic challenge. We should not misdiagnose nodular fasciitis as a sarcoma because of its high Ki67 index. The recurrence of nodular fasciitis is rare; and the utility of Ki67 immunostaining may be not suitable for recurrence assessment in nodular fasciitis. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/4782335818876666.

  12. Infantile nodular fasciitis of the hand: A case report and literature review

    Directory of Open Access Journals (Sweden)

    I Weng Lao

    2016-09-01

    Full Text Available Pediatric nodular fasciitis is uncommon and has a preference for the head and neck region. Occurrence in other anatomic locations is uncommon. We describe here a case of nodular fasciitis that arose in the hand of a newborn infant who presented with a rapidly growing mass. On MRI, it was heterogeneous isointense on T1-weighted and hyperintense on T2-weighted images. Histological examination showed short intersecting fascicles of uniform spindled myofibroblasts embedded in a myxoid to collagenous stroma, consistent with a nodular fasciitis. However, the lesion was initially diagnosed as an infantile fibrosarcoma due to the rapid growth, brisk mitotic activity and focally infiltrative architecture. This study illustrates that unusual presentation of nodular fasciitis may cause diagnostic confusion.

  13. Nodular Fasciitis of the Orbit: A Case Report Confirmed by Molecular Cytogenetic Analysis.

    Science.gov (United States)

    Anzeljc, Andrew J; Oliveira, Andre M; Grossniklaus, Hans E; Kim, Hee Joon; Hayek, Brent

    2016-02-12

    Nodular fasciitis is a benign fibroblastic proliferation typically found in the subcutaneous tissue or superficial fascia of the extremities that is often confused for malignancy. These lesions rarely occur on the eyelids and ocular adnexa and are seldom analyzed by ophthalmic pathologists. USP6 gene rearrangement has been recently demonstrated in nodular fasciitis and this rearrangement may lead to the formation of a fusion gene MYH9-USP6 in some cases. Herein, the authors describe a 38-year-old woman with a 6-month history of a progressively enlarging mass beneath her right medial upper eyelid. Histopathologic analysis of the excisional biopsy confirmed classic features of nodular fasciitis. Molecular cytogenetic analysis revealed a rearrangement of the USP6 locus, confirming the diagnosis of benign nodular fasciitis.

  14. Airport Heterotopia

    DEFF Research Database (Denmark)

    Christiansen, Steen Ledet

    Airports are areas of transit, places of in-between-ness where mobility is key; airports function not just as transfer points where people are moved from one place to another, but also as areas where mobile technology is critically important to make sure that travellers can stay connected....... The airport serves as a node in the network of flows that is air travel. Airports orchestrate social life into distinct movements and behaviors. The ontology of the airport is peculiarly split between a sense of placelessness, while at the same time being a place of material organization and social complexity....... It is a system of interconnected material worlds, and thus a heterotopia; a blending space of overlapping ontologies. Ursula Le Guin playfully examines this concept of overlapping ontologies in her short story collection Changing Planes, where airport travellers can shift realities due to the unpleasantries...

  15. Nodular glomerulosclerosis in patients’ without history of diabetes mellitus: a case report

    Science.gov (United States)

    Goucha, Rym; Karoui, Cyrine; Abderrahim, Ezzedine; Hamida, Fethi Ben; Elyounsi, Fethi; Maiz, Hedi Ben; Abdallah, Taieb Ben; Kheder, Adel

    2009-01-01

    Introduction Diabetic nephropathy can occur during the course of both type1 and type 2 diabetes mellitus. The characteristic lesions are diffuse or nodular (Kimmelsteil-Wilson) diabetic glomerulosclerosis. The reported cases represent unusual presentations of diabetes mellitus. Case presentation We report the case of a 49-year-old man without prior history of diabetes mellitus who presented with rapidly progressive renal failure and whose renal biopsy revealed nodular (Kimmelsteil-Wilson) glomerulosclerosis lesions characteristic of diabetes. Conclusion Renal manifestations of diabetes mellitus may antedate other more common presenting symptoms of this disease and we critically review the literature on this subject. PMID:19918545

  16. Nodular glomerulosclerosis in a non-diabetic hypertensive, dyslipidemic, smoker patient: a case report

    Directory of Open Access Journals (Sweden)

    Liliane Silvano Araújo

    Full Text Available Abstract Introduction: This is a case report of a patient with idiopathic nodular glomerulosclerosis whose pathogenesis and morphology are similar to diabetic nephropathy. Case presentation: A 64-year-old Brazilian man, leukoderma, dyslipidemic, obese with chronic obstructive pulmonary disease secondary to tobacco smoking, known to be hypertensive for five years and he had no history of diabetes. He was admitted with sudden anasarca, rapid loss of renal function and needed to start hemodialysis immediately. Renal biopsy was performed, and the sections were examined by light microscopy, immunofluorescence and electron microscopy. Morphological and ultrastructural findings showed that the profile of the disease studied herein strongly resembles diabetic nephropathy. However, the absence of diabetes mellitus, the presence of arteriolar hyalinosis in renal arterioles, tobacco smoking, and other clinical factors observed can play a significant role in nodular formation. Conclusion: The clinical features of the patient, and most importantly, the fact that he is a smoker, favor the diagnosis of "nodular glomerulosclerosis associated with smoking", a nomenclature proposed by some authors as an alternative to the term idiopathic nodular glomerulosclerosis. This clinical case report highlights idiopathic nodular glomerulosclerosis as a rare disease of little known etiopathogenesis; thus, further studies are necessary in order to elucidate the causes of this disease.

  17. Association between obesity and focal nodular hyperplasia telangiectasia. 24 cases re-evaluation

    Directory of Open Access Journals (Sweden)

    Pérez Rojas, J.¹; Guarín Corredor, M. J.; Artes Martínez, M. J.¹; Vera Sempere, F. J.¹, ²; Brisa Estelles, C.¹; Huart Peris, M. C.¹; Hernández Girón, S.¹

    2013-03-01

    Full Text Available Focal nodular hyperplasia is not a true neoplasm. Itis a regenerative response of hepatocytes to a vascular abnormality.24 cases were re-evaluated and diagnosed at pathologic examination confirmed as focal nodular hyperplasia.Three of the 24 cases were reclassified as inflammatory telangiectatic adenomas with imnumorreactividadagainst amyloid A.The presence of vascular and sinusoidal dilatation,congestion, peliotic areas with signs of inflammationassociated with focal or diffuse immunoreactivity compared to Amyloid are histological signs that indicatethe presence of inflammatory telangiectatic hepatocellular adenomas, formerly classified as focal nodularhyperplasia, atypical.An increased reactivity to Amyloid and associationmetabolic syndrome characterizes inflammatory telangiectatic adenomas.

  18. Intra-articular Nodular Fasciitis: An Unexpected Diagnosis for a Joint Lesion: A Case Report

    Directory of Open Access Journals (Sweden)

    MF Michelle Chan

    2014-07-01

    Full Text Available Pathological lesions in and around a joint can arise from underlying dermis, subcutis, deep muscle, bone or synovium. Clinical presentation can include joint pain, joint swelling, palpable masses and mechanical restriction. Whilst giant cell tumour of tendon sheath, pigmented villonodular synovitis, synovial chondromatosis, lipoma arborescens, juxta articular myxomas and inflammatory arthritis are the better-known conditions of the joint. Intra-articular nodular fasciitis, on the other hand, is less well recognized both clinically and radiologically. It is rarely seen in routine practice and is only described in case reports in the literature. Due to the non-specific clinical and radiological findings as well as the unfamiliarity with the entity, the diagnosis of intra-articular nodular fasciitis is usually clinched only after histological examination. We present a case of intra-articular nodular fasciitis arising in the knee joint which was not suspected clinically or radiologically.

  19. Glial heterotopia of the oral cavity

    Directory of Open Access Journals (Sweden)

    Radhames E. Lizardo

    2015-07-01

    Full Text Available We report an unusual case of a glial heterotopia arising from the oral cavity of an African neonate. The patient presented with an external pedunculated oral mass which was connected to the anterior hard palate by a firm, rubbery stalk of mucosal tissue. While the mass appeared painless, it interfered with the infant's feeding and was disturbing to the parents. After a computed tomography scan excluded an intracranial connection, the mass was excised at its base and sent for biopsy. Histopathology examination confirmed glial heterotopia. Glial heterotopias should be included in the differential diagnosis of congenital masses in the oral region.

  20. [Bilateral excavated nodular pneumopathy: amebiasis? Report of a case].

    Science.gov (United States)

    Ayadi, H; Rekik, W K; Ayoub, A K

    2001-12-01

    Pleuropulmonary amibiasis is generally secondary to hepatic amibiasis with migration into the thorax. Direct pulmonary involvement is exceptional. We report a case of pulmonary ambiasis without associated liver involvement causing multiple bilateral pulmonary lesions.

  1. Nodular Esophageal Xanthoma: A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Ahmed Dirweesh

    2017-01-01

    Full Text Available Xanthomas are localized nonneoplastic lesions within tissues that may manifest as papules, plaques, or nodules. These lesions can be found anywhere along the gastrointestinal tract, commonly in the stomach and colon, and rarely in the small intestine and esophagus. Esophagogastroduodenoscopy (EGD with biopsy is the gold standard tool for diagnosis. Here, we report a rare case of a lower solitary nodular esophageal xanthoma in an elderly black female. Correspondingly, all cases of esophageal xanthomas reported in the English medical literature were reviewed and presented with the reported case.

  2. [Analysis of predictors of malignancy of nodular goiters: about 500 cases].

    Science.gov (United States)

    Bouaity, Brahim; Darouassi, Youssef; Chihani, Mehdi; Touati, Mohamed Mliha; Ammar, Haddou

    2016-01-01

    Thyroid nodules are very common and less than 10% of them are malignant. They pose a serious diagnostic and therapeutic problem with respect to their benign or malignant nature. The study of some clinical and paraclinical factors for presumed malignancy makes it possible to codify appropriate therapeutic strategy. The aim of this study was to investigate predictors of malignancy in nodular goiters and to compare our results with those reported in the literature. This retrospective study consisted of 500 cases of nodular goiter operated in the Department of Otorhinolaryngology (ear, nose and throat or ENT) and Head and Neck Surgery at Avicenne military hospital in Marrakech between 2006 and 2012. The percentage of cancers was 6,8%. The average age of our patients was 46 years, with a sex-ratio of 5 (F/H). The hard nature of the nodule was present in 94,4% of the cases of cancer by palpation; irregular boundaries were present in 64.70% of the cases of cancer. Three nodules were fixed and malignant. Cervical lymphadenopathy were observed in 8 patients, 7 of which had cancer. Ultrasound examination showed hypoechoic appearance in 61,8% of the malignant nodules, with smooth-edges in 88,24% of the cases. Intranodular vascularization was found in 35,3% of the cases of cancers, with microcalcifications in 55,9% of the cases. Perinodular hypoechoic halo was incomplete in 73,5% of the cases of cancer. Our patients were euthyroid in 84,6% of the cases. Predictors of malignancy in nodular goiters were present in our first clinical study: patients over the age of 60 years, hard consistency of nodule, fixity, irregular and poorly defined character by palpation, as well as presence of cervical adenopathy on examination; and echographic features: hypoechoic character, smooth-edges, presence of microcalcifications and visualization of intranodular vascularization with or without peri-nodular vascularization. Although some of these factors are highly predictive of malignancy, only

  3. Sclerosing angiomatoid nodular transformation of the spleen:report of five cases and review of literature

    Institute of Scientific and Technical Information of China (English)

    WANG Hao-lu; LI Ke-wei; WANG Jian

    2012-01-01

    Sclerosing angiomatoid nodular transformation (SANT) of the spleen,a newly defined primary lesion of the spleen,is very rare.Immunohistochemistry is the only way to confirm the diagnosis of SANT.We present the clinical characteristics and postoperative outcomes of five SANT cases that underwent splenectomy from January 2007 to October 2010.Although SANT had specific imaging findings,differential diagnosis from other splenic tuomrs or malignant lesions preoperatively was difficult.The hand-assisted laparoscopic splenectomy was a useful and effective technique for the management and postoperative diagnosis of SANT.All SANT patients had good prognosis without recurrence after splenectomy.

  4. Primary pigmented nodular adrenocortical disease associated with Carney complex: case report and literature review

    Directory of Open Access Journals (Sweden)

    Fabrícia Torres Gonçalves

    Full Text Available CONTEXT: Carney complex (CNC, a familial multiple neoplasm syndrome with dominant autosomal transmission, is characterized by tumors of the heart, skin, endocrine and peripheral nervous system, and also cutaneous lentiginosis. This is a rare syndrome and its main endocrine manifestation, primary pigmented nodular adrenal disease (PPNAD, is an uncommon cause of adrenocorticotropic hormone-independent Cushing's syndrome. CASE REPORT: We report the case of a 20-year-old patient with a history of weight gain, hirsutism, acne, secondary amenorrhea and facial lentiginosis. Following the diagnosing of CNC and PPNAD, the patient underwent laparoscopic bilateral adrenalectomy, and she evolved with decreasing hypercortisolism. Screening was also performed for other tumors related to this syndrome. The diagnostic criteria, screening and follow-up for patients and affected family members are discussed.

  5. Church as heterotopia

    Directory of Open Access Journals (Sweden)

    Tanya van Wyk

    2014-02-01

    Full Text Available This article reflects on an ecclesiastical institution as a spatial panoptic structure which domesticates representational space as a hierarchy of power devoid of a sensitivity for the ‘human Other’ (Autrui. The notion of heterotopia is promoted to deconstruct spatiality and linearity (time as theological binary concepts. Being church as heterotopia does not deny the desire for the utopian dimension in religious thinking but holds on to utopian thinking amidst adversity and diversity. Therefore the concept of heterotopia is used to describe reconciliatory diversity, which is characteristic of an inclusive postmodern church which is a space where unity is not threatened by diversity, where the one is not afraid of the Other.

  6. Church as heterotopia

    Directory of Open Access Journals (Sweden)

    Tanya van Wyk

    2014-09-01

    Full Text Available This article reflects on an ecclesiastical institution as a spatial panoptic structure which domesticates representational space as a hierarchy of power devoid of a sensitivity for the ‘human Other’ (Autrui. The notion of heterotopia is promoted to deconstruct spatiality and linearity (time as theological binary concepts. Being church as heterotopia does not deny the desire for the utopian dimension in religious thinking but holds on to utopian thinking amidst adversity and diversity. Therefore the concept of heterotopia is used to describe reconciliatory diversity, which is characteristic of an inclusive postmodern church which is a space where unity is not threatened by diversity, where the one is not afraid of the Other.

  7. [Adenomyoma of the stomach (pancreatic heterotopia)--case report and review of the literature].

    Science.gov (United States)

    Barnert, J; Kamke, W; Frosch, B

    1985-07-01

    A case report is given of a patient, who harbored a gastric adenomyoma; this is a special form of heterotopic pancreatic tissue including excessive formation of smooth muscle tissue. Size and localization of the tumor were unusual in our case. The case presented is discussed taking into account the literature available.

  8. [A case of locally recurrent breast cancer difficult to differentiate from nodular fasciitis].

    Science.gov (United States)

    Kakimoto, Masaki; Nakata, Takuya; Imaizumi, Ken; Hirano, Takayuki; Yamamoto, Youhei; Chikatani, Kenichi; Hoshino, Mayumi; Matsuyama, Takatoshi; Motoyama, Kazuo; Goto, Hiroshi; Yoshimura, Tetsunori; Koshiishi, Haruya; Tsuruta, Kouji

    2014-11-01

    Breast-conserving surgery was performed on a 78-year-old woman for left breast cancer 5 years previously (invasive ductal carcinoma, T1cN2M0, stage IIIA, ER[+], PR[-], HER2[-]). Chemotherapy, radiotherapy, and hormonal therapy were administered. A left subclavian tumor was detected, and an excisional biopsy was performed. Histological examination showed spindle cells, different from primary breast cancer histology, and nodular fasciitis was diagnosed negative cytokeratin and vimentin immunostaining results. After 12 months, a mass had developed in the same region, and reoperation was performed for resection. Similar spindle cells were observed, but they tested positive for cytokeratin. Carcinoma was diagnosed and thought to be locally recurrent breast cancer. Despite postoperative chemotherapy, the patient experienced bone and lung metastasis and a third local recurrence. She died 13 months following the last surgery. Recurrent breast cancer sometimes displays different histology from the initial cancer, and mimics stromal tumors in certain cases.

  9. Scleroderma with Nodular Scleroderma

    OpenAIRE

    Chutika Srisuttiyakorn; Kobkul Aunhachoke

    2016-01-01

    Background: Nodular scleroderma is a rare variant of scleroderma which can occur in connection with systemic sclerosis or morphea. A biopsy from the lesion can demonstrate the scleroderma pattern, i.e., keloid pattern or mixed type. Treatment is challenging, and several treatments modalities have been reported with unsatisfactory results. Main Observations: We present a case of systemic sclerosis in a 50-year-old female who developed nodular scleroderma in the absence of deterioration of the ...

  10. Glial heterotopia of the lip: A rare presentation

    Directory of Open Access Journals (Sweden)

    Mehmet Dadaci

    2016-01-01

    Full Text Available Glial heterotopia represents collections of normal glial tissue in an abnormal location distant to the central nervous system or spinal canal with no intracranial connectivity. Nasal gliomas are non-neoplastic midline tumours, with limited growth potential and no similarity to the central nervous system gliomas. The nose and the nasopharynx are the most common sites of location. Existence of glial heterotopia in the lip region is a rare developmental disorder. We report a case of large glial heterotopia in the upper lip region in a full-term female newborn which had intracranial extension with a fibrotic band. After the surgery, there was no recurrence in the follow-up period of 3 years. When glial heterotopia, which is a rare midline anomaly, is suspected, possible intracranial connection and properties of the mass should be evaluated by magnetic resonance imaging. By this way, lower complication rate and better aesthetic results can be achieved with early diagnosis and proper surgery.

  11. Glial heterotopia of the lip: A rare presentation

    Science.gov (United States)

    Dadaci, Mehmet; Bayram, Fazli Cengiz; Ince, Bilsev; Bilgen, Fatma

    2016-01-01

    Glial heterotopia represents collections of normal glial tissue in an abnormal location distant to the central nervous system or spinal canal with no intracranial connectivity. Nasal gliomas are non-neoplastic midline tumours, with limited growth potential and no similarity to the central nervous system gliomas. The nose and the nasopharynx are the most common sites of location. Existence of glial heterotopia in the lip region is a rare developmental disorder. We report a case of large glial heterotopia in the upper lip region in a full-term female newborn which had intracranial extension with a fibrotic band. After the surgery, there was no recurrence in the follow-up period of 3 years. When glial heterotopia, which is a rare midline anomaly, is suspected, possible intracranial connection and properties of the mass should be evaluated by magnetic resonance imaging. By this way, lower complication rate and better aesthetic results can be achieved with early diagnosis and proper surgery. PMID:27274134

  12. Primary pigmented nodular adrenocortical disease presenting with a unilateral adrenocortical nodule treated with bilateral laparoscopic adrenalectomy: a case report

    Directory of Open Access Journals (Sweden)

    Kaltsas Gregory

    2010-07-01

    Full Text Available Abstract Introduction Primary pigmented nodular adrenocortical disease is a rare cause of adrenocorticotropic hormone-independent Cushing's syndrome. We report an uncommon primary pigmented nodular adrenocortical disease case presenting with a unilateral adrenocortical nodule and provide a brief overview of the existing literature. Case presentation A 27-year-old Caucasian woman was admitted to our Department with adrenocorticotropic hormone-independent Cushing's syndrome. Its cause was initially considered a left adrenocortical adenoma based on computer tomography imaging. The patient underwent left laparoscopic adrenalectomy and histological examination revealed pigmented micronodular adrenal hyperplasia. Evaluation for the presence of Carney complex was negative. Six months later recurrence of hypercortisolism was documented and a right laparoscopic adrenalectomy was performed further establishing the diagnosis of primary pigmented nodular adrenocortical disease. After a nine-year follow-up there is no evidence of residual disease. Conclusions Even though primary pigmented nodular adrenocortical disease is a rare cause of Cushing's syndrome, it should be included in the differential diagnosis of adrenocorticotropic hormone-independent Cushing's syndrome, especially because adrenal imaging can be misleading mimicking other adrenocortical diseases. Bilateral laparoscopic adrenalectomy is the preferred treatment in these subjects.

  13. 脑灰质异位症致难治性癫痫1例%A report of 1 case of refractory epilepsy caused by brain gray matter heterotopia

    Institute of Scientific and Technical Information of China (English)

    孙红霞; 陶寻明

    2014-01-01

    目的:脑灰质异位症所导致的癫痫是难治性癫痫的常见原因,MRI检查是诊断大脑灰质异位症最敏感的方法。对无临床症状的脑灰质异位症,一般不需要治疗。癫痫患者应使用抗癫痫药物控制其发作。脑灰质异位症临床少见,结合其发病特点,对儿童和青少年期起病的癫痫尤其是难治性癫痫患者以及出生后体格、精神发育迟滞的患者均宜行脑部影像学检查,尤其是MRI检查,以防误诊误治。本文介绍分析了1例脑灰质异位症患者的临床资料。%Brain gray matter heterotopia caused by epilepsy is a common cause of refractory epilepsy.MRI is the most sensitive method for diagnosis of brain gray matter heterotopia.For asymptomatic brain gray matter heterotopia,treatment is generally not need.Epilepsy antiepileptic drugs should be used to control its attack. Brain gray matter heterotopia is clinical rare.Combining with the characteristics of the onset,Children and adolescent onset of epilepsy,especially in patients with refractory epilepsy, physical,mental retardation patients after birth are suitable for brain imaging,especially MRI examination,in order to prevent misdiagnosis. In this paper, the clinical data of 1 case of brain gray matter heterotopia is analyzed.

  14. Huge focal nodular hyperplasia presenting in a 6-year-old child: A case presentation.

    Science.gov (United States)

    Zhuang, Lin; Ni, Chuangye; Din, Wenbing; Zhang, Feng; Zhuang, Yi; Sun, Yawei; Xi, Dong

    2016-01-01

    Focal nodular hyperplasia (FNH) is a benign lesion of the liver which is usually found in healthy adults, however, FNH is rare in children, and comprises only 2% of all pediatric liver tumors. Herein, we report the case of a 6-year-old child (male) with a huge FNH which size is more than 10cm. This could be the biggest FNH among all children's FNH cases ever reported. A 6-year-old boy was found a hepatic space-occupying lesion two years ago. As the time went by, the lesion became bigger gradually. The last CT examination showed the size of the tumor to be 10.5×9.9cm in the right hepatic lobe. This child underwent surgical resection of the tumor which was confirmed as FNH (11×8×7cm) by pathology. FNH is a benign lesion of the liver, and it is characterized by hepatocyte hyperplasia and a central stellate scar. It is uncommon for FNH to be diagnosed in children. Such huge FNH (about 11cm) is extremely rare. Surgical operation may be the effective method to cure huge FNH. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  15. [Rapidly-growing nodular pseudoangiomatous stromal hyperplasia of the breast: case report].

    Science.gov (United States)

    Elıyatkin, Nuket; Karasu, Başak; Selek, Elif; Keçecı, Yavuz; Postaci, Hakan

    2011-01-01

    Pseudoangiomatous stromal hyperplasia is a benign proliferative lesion of the mammary stroma that rarely presents as a localized mass. Pseudoangiomatous stromal hyperplasia is characterized by a dense, collagenous proliferation of the mammary stroma, associated with capillary-like spaces. Pseudoangiomatous stromal hyperplasia can be mistaken with fibroadenoma on radiological examination or with low-grade angiosarcoma on histological examination. Its main importance is its distinction from angiosarcoma. The presented case was a 40-year-old woman who was admitted with a rapidly growing breast tumor. Physical examination revealed an elastic-firm, well-defined, mobile and painless mass in her right breast. Mammograms revealed a 6.7 x 3.7 cm, lobulated, well-circumscribed mass in her right breast but no calcification. Sonographic examination showed a well-defined and homogenous mass, not including any cyst. Based on these findings, a provisional diagnosis of fibroadenoma was made. Considering the rapid growth history of the mass, tumor excision was performed. The excised tumor was well demarcated and had a smooth external surface. Histological examination revealed the tumor to be composed of markedly increased fibrous stroma and scattered epithelial components (cystic dilatation of the ducts, blunt duct adenosis). The fibrous stroma contained numerous anastomosing slit-like spaces. Isolated spindle cells appeared intermittently at the margins of the spaces resembled endothelial cells. Immunohistochemical staining showed that the spindle cells were positive for CD34 and negative for Factor VIII-related antigen. The lesion was diagnosed as nodular pseudoangiomatous stromal hyperplasia.

  16. Nodular Regenerative Hyperplasia of Liver Mimicking Cirrhosis:a Case Report

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    A 34-year-old man with no history of any abdominal pain or fatigue was admitted to our hospital in June 2008 due to the cirrhosis found incidentally during a physical examination. Laboratory examination, electrocardiograph, abdominal ultrasonography and magnetic resonance imaging were carried out during his hospitalization. However, according to the results of the above measures, the diagnosis of nodular regenerative hyperplasia of the liver (NRHL) could not be made. The result of electrocardiograph showed there was no sinus bradycardia. The abdominal ultrasonography showed evidence of hepatosplenomegaly, and magnetic resonance imaging showed multiple non-enhancing hepatic nodules. Histologic conifrmation was available by means of liver biopsy and the deifnitive diagnosis of NRHL was conifrmed histologically by liver biopsy. NRHL always presents with signs of portal hypertension with little evidence of obvious liver disease, NRHL may mimick the cirrhosis of liver and be easily confused with cirrhosis of the liver nodules, so liver biopsy should be recommended for correct diagnosis. The clinical, radiological and pathologic features of this case with NRHL was reported in order to familiarize the physicians with its clinical manifestations.

  17. Discordant lymphoma consisting of mediastinal large B-cell lymphoma and nodular sclerosis Hodgkin lymphoma in the right supraclavicular lymph nodes: a case report

    National Research Council Canada - National Science Library

    Zhang, Chun; Yi, Yuanxue; Chen, Chunyan; Wang, Jianrong; Liu, Zhu

    2015-01-01

    .... Here, we report a case of discordant lymphoma in a 34-year-old female patient that involved mediastinal large B-cell lymphoma and nodular sclerosis Hodgkin lymphoma in the right supraclavicular lymph nodes...

  18. The importance of a proper selection area to be biopsied in nodular leukoplakia: a case report.

    Science.gov (United States)

    Pagin, Otávio; Santos, Paulo Sérgio da Silva; Del Neri, Nathalia Bigelli; Gustavo de Lima, Heliton; Lara, Vanessa Soares

    2014-03-01

    Nodular leukoplakia is a non-homogeneous type of oral leukoplakia presenting a white surface with verrucous, nodular, ulcerated or erythematous features with a greater risk of malignant transformation when compared to the homogeneous type. Common sites of involvement include lip commissures, buccal mucosa and soft palate. It is often associated with epithelial dysplasia or carcinoma and requires detailed microscopic assessment and regular follow-up. The importance of a proper selection of the area to be biopsied and the close teamwork between a dentist and oral pathologist is the basis of providing an accurate final diagnosis.

  19. Rapidly-Growing Nodular Pseudoangiomatous Stromal Hyperplasia of the Breast: Case Report

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    Nuket ELİYATKIN

    2011-09-01

    Full Text Available Pseudoangiomatous stromal hyperplasia is a benign proliferative lesion of the mammary stroma that rarely presents as a localized mass. Pseudoangiomatous stromal hyperplasia is characterized by a dense, collagenous proliferation of the mammary stroma, associated with capillary-like spaces. Pseudoangiomatous stromal hyperplasia can be mistaken with fibroadenoma on radiological examination or with low-grade angiosarcoma on histological examination. Its main importance is its distinction from angiosarcoma.The presented case was a 40-year-old woman who was admitted with a rapidly growing breast tumor. Physical examination revealed an elastic-firm, well-defined, mobile and painless mass in her right breast. Mammograms revealed a 6.7x3.7 cm, lobulated, well-circumscribed mass in her right breast but no calcification. Sonographic examination showed a well-defined and homogenous mass, not including any cyst. Based on these findings, a provisional diagnosis of fibroadenoma was made. Considering the rapid growth history of the mass, tumor excision was performed. The excised tumor was well demarcated and had a smooth external surface. Histological examination revealed the tumor to be composed of markedly increased fibrous stroma and scattered epithelial components (cystic dilatation of the ducts, blunt duct adenosis. The fibrous stroma contained numerous anastomosing slit-like spaces. Isolated spindle cells appeared intermittently at the margins of the spaces resembled endothelial cells. Immunohistochemical staining showed that the spindle cells were positive for CD34 and negative for Factor VIII-related antigen. The lesion was diagnosed as nodular pseudoangiomatous stromal hyperplasia.

  20. Heterotopias of Homelessness: Citizenship on the Margins

    Science.gov (United States)

    Mendel, Maria

    2011-01-01

    The concept of heterotopia challenges political theory, which has often focused on utopic thinking. Foucault describes a heterotopia as a heterogenous space that juxtaposes in a single real place several spaces, several sites that are in themselves incompatible. Streets, squares and parks form heterotopias when their utopic purity as public space…

  1. Bilateral macrostomia associated with aqueductal stenosis and glial heterotopias.

    Science.gov (United States)

    Pepe, Ernesto; Petricig, Paola; Peretta, Paola; Cinalli, Giuseppe

    2007-09-01

    We report on an Italian boy, born to normal and nonconsanguineous parents with a prenatal diagnosis of ventriculomegaly and subependymal glial heterotopias. At birth bilateral macrostomia was diagnosed without other evident facial anomalies. Magnetic resonance imaging (MRI) showed triventricular hydrocephalus and aqueductal stenosis and confirmed the nodules of glial heterotopia. The bilateral macrostomia was surgically corrected with the vermilion square flap method and W-plasty technique and follow up MRI at 6 months showed mild increase of ventricular dilatation without signs of active hydrocephalus. The association between macrostomia and hydrocephalus has been reported only in rare cases of complex malformative syndromes but never with isolated macrostomia.

  2. Hiperplasia nodular focal do fígado: apresentação de um caso e revisão da literatura Focal nodular hyperplasia of the liver: a case report and review of the literature

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    Marise Silva Teixeira

    2007-08-01

    Full Text Available Neste trabalho apresentamos um caso de hiperplasia nodular focal que foi diagnosticado aos seis anos de idade e que está sendo acompanhado até o momento presente. Para o diagnóstico foram imprescindíveis as técnicas de imagem, tendo importância de realce a cintilografia hepatoesplênica e a tomografia computadorizada. Apresentamos, também, revisão da literatura sobre o assunto.In this case report we discuss a focal nodular hyperplasia diagnosed in a female, six-year old patient, as well as her follow-up from the diagnosis to the present time. Imaging techniques, particularly hepatosplenic scintigraphy and computed tomography, are essential for the diagnosis. Also, a literature review is presented.

  3. Nodular Fasciitis of the Orbit.

    Science.gov (United States)

    Compton, Christopher J; Clark, Jeremy D; Thompson, Matthew P; Lee, Hui Bae H; Nunery, William R

    A 13-month-old boy was presented with new onset proptosis of the right eye. CT scan and MRI showed an enhancing mass in the right superior orbit with local bone remodeling and erosion. A craniotomy was performed for biopsy and sub-total resection. Histopathology and immunohistochemistry confirmed the lesion to be nodular fasciitis. Nodular fasciitis lesions are classically found in the anterior ocular adnexa, especially in pediatric patients. This is the first reported case of nodular fasciitis arising in the posterior orbit of a child younger than 16.

  4. Malignant Nodular Hidradenoma of Face

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    Bansal N

    2014-10-01

    Full Text Available We report a case of malignant nodular hidradenoma in an old woman, who presented with a nodular swelling in the right side of nose near the medial canthus of the right eye. Wide excision of the nodular mass with a clear margin of healthy surrounding tissue was performed along with primary closure. Post operatively, adjuvant radiation therapy was given on a telecobalt machine due to the presence of high risk features. In general, malignant forms of hidradenomas are not usual and treatment strategies should be individualized.

  5. Persistent nodular contact dermatitis to gold: Case report of two cases

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    Mehta Vandana

    2010-01-01

    Full Text Available Metallic gold has long been regarded as a relatively safe and inert material when in contact with the skin and mucosal membranes, with only sporadic reports of allergic contact dermatitis. We report two cases, where persistent nodules developed at sites of gold piercing with gold jewelry with positive patch test reactions to gold.

  6. Scleroderma with Nodular Scleroderma

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    Chutika Srisuttiyakorn

    2016-11-01

    Full Text Available Background: Nodular scleroderma is a rare variant of scleroderma which can occur in connection with systemic sclerosis or morphea. A biopsy from the lesion can demonstrate the scleroderma pattern, i.e., keloid pattern or mixed type. Treatment is challenging, and several treatments modalities have been reported with unsatisfactory results. Main Observations: We present a case of systemic sclerosis in a 50-year-old female who developed nodular scleroderma in the absence of deterioration of the scleroderma condition. Although no additional treatment was given, the lesions remained stable without progression. Conclusions: Although this condition is rare, it has been reported sporadically, and clinicians should be able to recognize this variant in cases of scleroderma presenting with firm nodules or plaques.

  7. Glial Heterotopia of the orbit: A rare presentation

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    Sitaula Ranju

    2011-11-01

    Full Text Available Abstract Background Glial heterotopias are rare, benign, congenital, midline, non-teratomatous extracranial glial tissue. They may masquerade as encephalocoele or dermoid cyst and mostly present in nose. Herein, we present an unusual case of glial heterotopia of the orbit with unilateral blindness. Case presentation A 6 year-old-boy presented with a progressive painless mass over the nose and medial aspect of the left eye noticed since birth. On examination, the globe was displaced laterally by a firm, regular, mobile, non-pulsatile and non-tender medial mass. The affected eye had profound loss of vision. Computed tomography scan showed a large hypodense mass in the extraconal space with no intracranial connectivity and bony erosion. The child underwent total surgical excision of the mass and histopathological examination confirmed glial heterotopia of the orbit. Conclusion Though the incidence of this condition is rare, the need of appropriate diagnosis and management of such mass to prevent the visual and cosmetic deterioration is warranted. To our knowledge this is the first reported case of Glial heterotopia of orbit causing unilateral blindness.

  8. Integration of gray matter nodules into functional cortical circuits in periventricular heterotopia

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    Christodoulou, Joanna A.; Barnard, Mollie E.; Del Tufo, Stephanie N.; Katzir, Tami; Whitfield-Gabrieli, Susan; Gabrieli, John D.E.; Chang, Bernard S.

    2013-01-01

    Alterations in neuronal circuitry are recognized as an important substrate of many neurological disorders, including epilepsy. Patients with the developmental brain malformation of periventricular nodular heterotopia (PNH) often have both seizures and dyslexia, and there is evidence to suggest that aberrant neuronal connectivity underlies both of these clinical features. We used task-based functional MRI (fMRI) to determine whether heterotopic nodules of gray matter in this condition are integrated into functional cortical circuits. Blood oxygenation level-dependent (BOLD) fMRI was acquired in eight participants with PNH during the performance of reading-related tasks. Evidence of neural activation within heterotopic gray matter was identified, and regions of cortical co-activation were then mapped systematically. Findings were correlated with resting-state functional connectivity results and with performance on the fMRI reading-related tasks. Six participants (75%) demonstrated activation within at least one region of gray matter heterotopia. Cortical areas directly overlying the heterotopia were usually co-activated (60%), as were areas known to have functional connectivity to the heterotopia in the task-free resting state (73%). Six of seven (86%) primary task contrasts resulted in heterotopia activation in at least one participant. Activation was most commonly seen during rapid naming of visual stimuli, a characteristic impairment in this patient population. Our findings represent a systematic demonstration that heterotopic gray matter can be metabolically coactivated in a neuronal migration disorder associated with epilepsy and dyslexia. Gray matter nodules were most commonly coactivated with anatomically overlying cortex and other regions with resting-state connectivity to heterotopia. These results have broader implications for understanding the network pathogenesis of both seizures and reading disabilities. PMID:24090774

  9. Educational Heterotopias and the Self

    Science.gov (United States)

    Tamboukou, Maria

    2004-01-01

    This article looks at the first university-associated colleges in the United Kingdom at the turn of the nineteenth century, and at how the first women students of these colleges lived within the limits of their society, but also beyond them, in yet unrecognised "different social spaces," which Foucault has described as "heterotopias." In…

  10. Fascitis nodular cervical en paciente gestante: revisión de la literatura y presentación de un caso Cervical nodular fasciitis in a pregnant woman: Review of the literature and presentation of a new case

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    Manuel Acosta-Feria

    2010-09-01

    Full Text Available La fascitis nodular es una lesión benigna rara, de crecimiento rápido, cuya patogenia es aún desconocida. Si bien a nivel de cabeza y cuello aparece en un 20% de los casos, su aparición en pacientes gestantes es extremadamente rara. Presentamos el segundo caso descrito en la literatura en el cual está presente dicha asociación. Mujer de 25 años y gestante de 13 semanas, con una tumoración retroauricular derecha de 3 cm de diámetro, 3 meses de evolución y rápido crecimiento. No presentaba parálisis facial ni dolor en la exploración inicial. Tras la exéresis quirúrgica de la lesión, el diagnóstico anatomopatológico definitivo de ésta, fue de fascitis nodular. Tras 2 años desde la intervención quirúrgica no se ha evidenciado recidiva de la tumoración, llevándose el embarazo a término sin presentar complicaciones ni para la madre ni para el feto.The nodular fasciitis is a rare benign lesion of rapid growth, whose pathogenesis is still unknown. While at the head and neck appeared in 20% of cases, its occurrence in pregnant patients is extremely rare. We report the second case described in the literature in which this association is present. Woman of 25 years and 13 weeks pregnant, who had a right auricular tumour 3 cm in diameter, 3 months of development and rapid growth. No facial paralysis or pain in the initial exploration. After surgical resection of the lesion, the final pathological diagnosis of the same was nodular fasciitis. After two years since the surgery, there was no evidence of recurrence of the tumour, taking ad términun pregnancy without complications or the mother or the fetus.

  11. Clinical Pathological Features of 1 168 Cases of Nodular Goiter%结节性甲状腺肿1168例临床病理分析

    Institute of Scientific and Technical Information of China (English)

    赵时梅; 罗宇; 史琳

    2013-01-01

    目的 探讨结节性甲状腺肿的临床病理特征.方法 回顾性分析1 168例结节性甲状腺肿的临床病理资料.结果 1 168例结节性甲状腺肿中,女性患者占88.1%,中位发病年龄为48岁.结节性甲状腺肿伴发或继发病变发生率高达57.6%,其中出血、坏死、钙化、囊性变,灶性淋巴细胞增生及桥本甲状腺炎发生率分别为20.4%、28.0%和0.3%.乳头状增生发生率为5.3%,甲状腺癌继发率为3.1%.结论 结节性甲状腺肿女性多发,继发病变多,诊断时应给予重视.%Objective To explore the clinical pathological features of nodular goiter. Methods The data of 1 168 nodular goiter were studied retrospectively. Results In all the 1168 cases,female patients occupied 88. 1% ,medianage was 48. Nodular goiter with the secondary cases was 57. 6% . Hemorrhage, necrosis, calcify, cystis degeneration; focal lymphoid hyperplasia; and hashimotos thyroiditis incidence in NG was 20. 4% ,28. 0% and 0. 3% ,respectively. The papillary hyperplasia was found in 5. 3% and the thyroid carcinoma was 3.1%. Conclusion Nodular goiter is more common in female than in male. The secondary cases are often found in nodular goiter and it should be given more attention.

  12. Amiloidosis oral nodular Oral nodular amyloidosis

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    P. Martos Díaz

    2008-02-01

    Full Text Available Introducción. La amiloidosis constituye una entidad marcada por el depósito de amiloide en diferentes tejidos. En la cavidad oral se manifiesta habitualmente en forma de macroglosia, y más raramente, como nódulos dispuestos en la superficie. Caso clínico. Varón afecto de Mieloma Múltiple, que comienza con lesiones nodulares en labio inferior y lengua. A raíz de estas lesiones, mediante estudio histológico, es diagnosticado de Amiloidosis Sistémica. Discusión. Los nódulos amiloideos en la cavidad oral, constituyen una manifestación rara de la amiloidosis sistémica. Su aparición conlleva la necesidad de realizar un diagnostico diferencial con otras entidades y el diagnostico de certeza se obtiene mediante el análisis histológico.Introduction. Amyloidosis is a condition characterized by the deposit of amyloid in different tissues. In the oral cavity it is usually manifested as macroglossia and, more rarely, as nodules on the surface. Clinical case. A man had multiple myeloma that began with nodular lesions of the lower lip and tongue. As a result of these lesions, the patient was diagnosed of systemic amyloidosis by histological study. Discussion. Amyloid nodules in the oral cavity are a rare manifestation of systemic amyloidosis. Its appearance entails the necessity to make I diagnose differential with other organizations and I diagnose of certainty is obtained by means of the histological analysis.

  13. Foucault's Heterotopia and Children's Everyday Lives.

    Science.gov (United States)

    McNamee, Sara

    2000-01-01

    Discusses Foucault's notion of "heterotopia"--real places but which exist unto themselves, such as a floating ship. Considers data on children's use of computer and video games to apply "heterotopia" to children's everyday social lives. Argues that childhood is subject to increasing boundaries, and that children create "other" spaces through…

  14. 39例超声引导下颈内静脉置管异位的原因分析与对策%Analysis and countermeasures of 39 cases of ultrasound guided internal jugular venous catheter heterotopia

    Institute of Scientific and Technical Information of China (English)

    江群; 泰英; 廖丽; 阳静; 梁英; 殷利

    2012-01-01

    Objective: Analyse the ectopic position, causes, and countermeasures of 39 cases of the ultrasound guided internal jugular venous catheter hetero-topia. Methods :2428 clinical cases reviewed retrospectively using ultrasound guided internal jugular venous catheter in our hospital's cath lab during March -December 2010. Results:39 cases of catheter heterotopia happened. The left side was significantly higher than occurred in the right(P<0.05), higher in female than male( P <0.05). The left side prone to happen in the contralateral innominate vein. The right side prone to happen in the ipsilateral axillary vein. Conclusion; Internal jugular venous catheter heterotopia was related to patients' gender,individual factors,vascular parts chosen for operation,the operators' skill levels,operators' personal habits,and the hospital's management factors.The success rate and complications can be improved by enhancing the operators' own awareness of improving their operatory skills, the carefulness of choosing the venipuncture parts, confirmation by using X-ray after the success of the puncture in time.%目的:总结39例超声引导下颈内静脉置管异位的部位、原因和对策.方法:回顾性分析我院导管室2010年3 ~12月期间采用超声引导下行颈内静脉置管2428例患者的临床资料.结果:发生导管异位39例,左侧异位发生率显著高于右侧(P<0.05),女性高于男性(P<0.05),左侧异位易发生在对侧的无名静脉,右侧异位易发生在同侧的腋静脉.结论:颈内静脉置管异位与患者性别、个体因素、血管选择部位、操作者技能水平、操作者的个人习惯有关.操作者重视自身技术水平的提高,操作中认真选择穿刺部位,穿刺成功后及时行X线检查确认,能提高颈内静脉穿刺置管成功率,减少并发症的发生.

  15. Comparative histopathology of scabies versus nodular scabies

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    Mittal R

    1997-01-01

    Full Text Available Comparative histopathology was studied in 25 cases of scabies versus 25 cases of nodular scabies which were selected from Dermato-Venereology out patients. Salient differences observed were that in scabies lifting of stratum corneum at places was seen in all 100% cases, spongiosis in 100%, spongiotic vesicles in 28%, burrows in 56%, mite in 40% and vasculitis in 28% whereas in nodular scabies acanthosis was seen in 100%, pseudo epitheliomatous hyperplasia in 8%, burrows in 48%, mite in 24% and vasculitis in 84%. In nodular scabies, dermal infiltrate in 32% cases was arranged as lymphoid follicles with admixture of plasma cells and eosinophils.

  16. Primary pigmented nodular adrenocortical disease

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    Marie T Manipadam

    2011-01-01

    Full Text Available Primary pigmented nodular adrenocortical disease (PPNAD is a rare cause of ACTH-independent Cushing′s syndrome and has characteristic gross and microscopic pathologic findings. We report a case of PPNAD in a 15-year-old boy, which was not associated with Carney′s complex. Bilateral adrenalectomy is the treatment of choice.

  17. Hepatic nodular lymphoid lesion with increased IgG4-positive plasma cells associated with primary biliary cirrhosis: a report of two cases.

    Science.gov (United States)

    Calvo, Jessica; Carbonell, Nicolas; Scatton, Olivier; Marzac, Christophe; Ganne-Carrie, Nathalie; Wendum, Dominique

    2015-11-01

    The nodular lymphoid lesion of the liver known as reactive lymphoid hyperplasia or pseudolymphoma is rare and its pathogenesis is unknown. We report two cases of nodular lymphoid lesions of the liver with numerous IgG4-positive plasma cells in patients with primary biliary cirrhosis. Histologically, in both cases, the lesion showed a dense lymphoplasmacytic infiltrate with lymphoid follicles and granulomas. Fibrous tissue was scarce and without a storiform pattern. Obliterative phlebitis was not identified. The IgG4+ plasma cell counts were 82 and 76 per high power field, with an IgG4/IgG ratio of 75 and 64 %, respectively, which qualifies the lesions according to the diagnostic criteria for IgG4-related disease as « probable histological feature of IgG4-related disease ». There were no rearrangements of immunoglobulin heavy-chain genes and plasma cells had a polytypic pattern of kappa and lambda light-chain expression. The non-tumor liver showed primary biliary cirrhosis with destructive cholangitis without IgG4 plasma cells. In both cases, IgG4-related disease was not found in other organs neither at the time of diagnosis nor 3 years later. Serum IgG4 levels normalized after local ablation of the lesions. It seems unlikely that these lesions are a manifestation of IgG4-related disease. However, because the pathogenesis of both nodular lymphoid lesions and IgG4-related disease remains unclear, further studies are needed to elucidate a potential link between nodular lymphoid lesions of the liver and an increased number of IgG4 plasma cells. More definite conclusions will be possible when the pathogenesis of IgG4-related disease has been clarified.

  18. UNUSUAL TYPE OF NODULAR LUNG DISEASE IN RHEUMATOID ARTHRITIS: A RARE CASE

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    Irina V Liskina

    2014-01-01

    Full Text Available The article presents a rare case of pulmonary manifestation of seropositive protracted rheumatoid arthritis in the form of bronchocentric granulomatosis. The algorithm for diagnosis is described in details in the context of the known literature on pulmonary manifestations as a complication of rheumatoid arthritis and morphology of bronchocentric granulomatosis.

  19. [Nodular regenerative hyperplasia associated with primary antiphospholipid syndrome].

    Science.gov (United States)

    Cadranel, J F; Demontis, R; Guettier, C; Bouraya, D; Dautreaux, M; Ghazali, A; Poux, J M; Coutarel, P; Devergie, B; Fievet, P

    1996-01-01

    Nodular regenerative hyperplasia of the liver is characterized by diffuse nodularity of the hepatic parenchyma without fibrotic septa. It may be related to venous or arterial obstruction in the portal tract. We report a case of primary antiphospholipid syndrome associated with nodular regenerative hyperplasia in a 45-year old woman. The patient had an ischemic stroke, associated with an acute arterial ischemia of the left leg. She had high titers of serum anticardiolipin antibodies. Nodular regenerative hyperplasia of the liver was histologically confirmed and was associated with anicteric cholestasis. This case provides additional evidence that a thrombotic mechanism may play a role in the pathogenesis of nodular regenerative hyperplasia of the liver.

  20. Clown nose: a case of disfiguring nodular squamous cell carcinoma of the face.

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    Colletti, Giacomo; Allevi, Fabiana; Moneghini, Laura; Palvarini, Marina

    2014-01-31

    'Clown nose' (CN) is the common medical term referring to a reddish-brown bulge involving the tip of the nose, reminding of a clown's fake red nose. Reports about these tumours are scarce. Most reports refer to metastatic skin manifestation of systemic malignancies: this condition has been rarely described as a primary skin neoplasm. We report a case of a 31-year-old patient with a giant cutaneous squamous cell carcinoma of the nose which evolved into a CN. After ruling out genetic or immune risk factors, the patient was treated with surgical excision of the lesion and local reconstruction with good aesthetic outcome and no recurrence over a 2-year follow-up.

  1. A Case of Colorectal Liver Metastasis with Central Scar Mimicking Focal Nodular Hyperplasia

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    Asawin Sudcharoen

    2017-05-01

    Full Text Available The authors report a case of colorectal liver metastasis which is one of the uncommon causes of liver tumor with central scar in a young female. Our patient presented with right upper abdominal discomfort and palpable liver mass for about 2 months. She did not have underlying disease. She had used oral contraceptive pills for 14 years. Physical examination revealed only liver span 16 centimeters (cm. Multidetector-row computed tomography demonstrated 3 masses and the largest one measured 10.7x 8.3x 7 cm in diameter with lobulated contour, hypodensity enhancing pattern, and a central scar at segment II and IVa of liver. Magnetic resonance imaging (MRI of the largest mass showed hyposignal intensity on T1-weighted and slightly hypersignal intensity in T2-weighted MRI. This mass also had a large central scar which was hyposignal intensity on T1-weighted and hypersignal intensity in T2-weighted MRI. Liver biopsy showed scattered infiltration of atypical epithelium with glandular formation. Immunohistochemical analysis was compatible with colorectal cancer. Colonoscopy was performed and revealed large mass at distal part of sigmoid colon. The patient was scheduled to undergo surgical operation and receive chemotherapy. To our knowledge, colorectal metastasis of liver should be considered as a cause of liver tumor with central scar.

  2. Gastric heterotopia in rectum: A literature review and its diagnostic pitfall

    Science.gov (United States)

    Dinarvand, Peyman; Vareedayah, Ashley A.; Phillips, Nancy J; Hachem, Christine; Lai, Jinping

    2017-01-01

    Objectives: The term heterotopia, in pathology, refers to the presence of normal tissues at foreign sites. Gastric heterotopia has been reported anywhere in the gastrointestinal tract. However, the presence of gastric heterotopia in the rectum is very rare. Methods: We, here, report a rare case of a localized 2-cm area of cratered mucosa with heaped-up borders in the rectum of a 51-year-old, asymptomatic woman who underwent screening colonoscopy. Results: Histologic examination of the biopsy from the lesional tissue in rectum demonstrated fragments of rectal mucosa co-mingling with oxyntic- and antral-type gastric mucosa. No intestinal metaplasia or Helicobacter pylori is identified. Conclusion: Patients with gastric heterotopia in rectum usually present with bleeding and/or abdominal pain. Definite treatment of choice is surgical or endoscopic resection, although the lesions also respond to histamine-2 receptor blockers. In this article, most recent literature about gastric heterotopia in rectum is reviewed, following a case presentation about it. PMID:28321304

  3. Gastric heterotopia in rectum: A literature review and its diagnostic pitfall

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    Peyman Dinarvand

    2017-02-01

    Full Text Available Objectives: The term heterotopia, in pathology, refers to the presence of normal tissues at foreign sites. Gastric heterotopia has been reported anywhere in the gastrointestinal tract. However, the presence of gastric heterotopia in the rectum is very rare. Methods: We, here, report a rare case of a localized 2-cm area of cratered mucosa with heaped-up borders in the rectum of a 51-year-old, asymptomatic woman who underwent screening colonoscopy. Results: Histologic examination of the biopsy from the lesional tissue in rectum demonstrated fragments of rectal mucosa co-mingling with oxyntic- and antral-type gastric mucosa. No intestinal metaplasia or Helicobacter pylori is identified. Conclusion: Patients with gastric heterotopia in rectum usually present with bleeding and/or abdominal pain. Definite treatment of choice is surgical or endoscopic resection, although the lesions also respond to histamine-2 receptor blockers. In this article, most recent literature about gastric heterotopia in rectum is reviewed, following a case presentation about it.

  4. Pancreatic Heterotopia: Masquerading as Malignancy - A 15-Year Single Institutional Surgicalpathology Review

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    Rani Kanthan

    2015-07-01

    Full Text Available Context Pancreatic heterotopia, the presence of pancreatic tissue anywhere outside of the anatomical pancreas, is rare and typically an incidental finding. This manuscript reports two index cases of unusual presentations of pancreatic heterotopia masquerading as malignant lesions. Case reports Case #1: Fifty-five year-old female with right upper quadrant pain was found to have a retroperitoneal tumor between the right kidney and liver. Case #2: Thirty-eight-year-old female with a 20-year history of right upper quadrant pain and pancreatitis was found to have an incidental jejunal mass. An intraoperative frozen section was ordered on these two patients for suspected malignancy. Frozen section analysis in both cases showed the presence of benign glandular tissue admixed with ducts in a typical lobular fashion consistent with benign pancreatic tissue, confirming pancreatic heterotopia. The two index cases were investigated and analyzed in detail with relevant review of the literature as available in PubMed and Medline. A 15-year retrospective computer-based histopathological surgical review was conducted in our laboratory and the results were analyzed in the context of evidence-based literature of pancreatic heterotopias. 153 pancreatic pathologies were identified of which the commonest lesion was adenocarcinoma (58.8% followed by pancreatic heterotopia (10.5%, pancreatic neuroendocrine tumors (7.2% and pancreatitis (7.2%. Conclusions Pancreatic heterotopia is rare and most often an incidental finding; however, occasionally patients may present with a mass suggestive of malignancy, leading to clinical diagnostic dilemmas. Awareness of this uncommon lesion is of particular importance at intraoperative frozen section analysis for lesions in atypical locations.

  5. Gray matter heterotopias: MR and clinical features

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    Moon, Tae Myung; Yoon, Jeong Hee; Chung, Chun Phil [Maryknoll Hospital, Busan (Korea, Republic of)

    1995-04-15

    To evaluate types of gray matter heterotopias, associated brain anomalies, and its correlation with the patterns of seizure. We evaluated retrospectively 19 patients (male:female=10:9, mean age 21 years) with gray matter heterotopias on brain MRI. Using 1.0T superconducting MR unit, spin echo T1-, proton -density and T2-weighted images in axial, coronal and sagittal planes were obtained. Types of gray matter heterotopias were single subependymal in four patients, multiple subependymal in one, focal subcortical in eight, diffuse subcortical in two, mixed multiple subependymal and focal subcortical in four. Associated anomalies were seen in 11 patients: other neuronal migration anomalies in eight patients, corpus callosum agenesis in two, and combined holoprosencephaly and Dandy-Walker malformation in one. Fifteen patients had seizure. The patterns of seizure were not correlated with the types of heterotopias. In addition to subependymal, focal subcortical, and diffuse subcortical types, gray matter heterotopias included mixed variant of multiple subependymal and subcortical type. Schizencephaly was the most common form of accompanying anomalies, and patterns of seizure were not correlated with types of gray matter heterotopias, even though main clinical manifestation was seizure.

  6. Clinical and pathological analysis of 10 cases of nodular fasciitis%结节性筋膜炎10例临床病理分析

    Institute of Scientific and Technical Information of China (English)

    张莉; 何凡桂

    2014-01-01

    Objective To study the clinical and pathological features,diagnosis and differential diagnosis of nodular fasciitis.Methods A retrospective analysis of the clinical data of 10 cases of nodular fasciitis patients,combined with previous literature data of nodular fasciitis of the clinical characteristics were analyzed,HE staining,light microscopy.Results Nodular fasciitis is found mostly in young adults,made good on the forearm,clinical manifestations:mass small,rapid growth,qualitative hard or brittle,boundary is not clear.To have diagnostic significance of histological features of fibroblasts to form a"S"shaped vortex,mitoses are easy to see,no pathological karyokinesis;small fissure formation;the extravasation of red blood cells,a small amount of inflammatory cells and new capillaries abundant myxoid matrix.Conclusion The diagnosis of nodular fasciitis should grasp the clinical characteristics,diagnosis with histological features,grasp its differential diagnosis,to prevent misdiagnosis for soft tissue sarcoma.%目的:探讨结节性筋膜炎的临床病理特点、诊断及鉴别诊断。方法:回顾性分析10例结节性筋膜炎患者的临床资料,结合以往文献资料对结节性筋膜炎的临床特点进行分析,HE染色,光镜观察。结果:结节性筋膜炎多见于青壮年,好发于上肢前臂,临床表现:肿块小、生长迅速、质硬或韧、边界不清。具有诊断意义的组织学特征为纤维母细胞形成“S”形漩涡,核分裂相易见,无病理性核分裂相;小裂隙形成;红细胞外渗、有少量的炎细胞及丰富的新生毛细血管;黏液样基质。结论:诊断结节性筋膜炎应抓住其临床特点、具有诊断意义的组织学特征,掌握其鉴别诊断,防止误诊为软组织肉瘤。

  7. Chlamydophila pneumoniae Infection Induced Nodular Vasculitis

    Directory of Open Access Journals (Sweden)

    H. Sakuma

    2011-12-01

    Full Text Available We present the case history of a 48-year-old male patient with Chlamydophila (Chlamydia pneumoniae who developed a nodular vasculitis. He developed a cutaneous vasculitis with the onset of respiratory symptoms. The diagnosis of Chlamydophila pneumoniae infection was based on serology. Since this infection is very common in our population, although often asymptomatic, it should be systematically considered as a causative agent of nodular vasculitis.

  8. Correlation between thyroid function and nodular goiter accompanied with gallstone

    Institute of Scientific and Technical Information of China (English)

    Shihong Ma; Qinjiang Liu; Xiaofeng Hou

    2014-01-01

    The-purpose-of-the-study-wass-to-explore-the-correlation-between-thyroid-function-and-nodular-goiter-accompanied-with-gal-stone.-Methods:We-col-ected-120-cases-about-nodular-goiter-accompanied-with-gal-stone-and-128-cases-about-nodular-goiter-and-establish-50-healthy-control-groups.-Detected-t-level-of-hyrotropic-hormone-(TSH),-total-tri-o-dothyronine-(TT3),-total-thyroxine-in-the-peripheral-venous-blood-of-these-cases-in-the-three-groups-by-using-electrochemilu-minescence-immunoassay,-measure-level-of-total-cholesterol-(TC),-high-density-lipoprotein-cholesterol-(HDL-C),-low-density-lipoprotein-cholesterol-(LDL-C)-and-total-bile-acid-(TBA)-levels-by-using-enzymic-method,-and-observed-the-changes-of-thyroid-function-and-blood-lipid-among-the-three-groups.-Results:The-serum-TT3-level-in-nodular-goiter-accompanied-with-gal-stone-group-and-the-nodular-goiter-group-was-significantly-lower-than-that-in-control-group-(P0.05).-Accordingly,-TC-and-LDL-C-level-in-nodular-goiter-accompanied-with-gal-stone-group-was-significantly-higher-than-that-in-nodular-goiter-and-control-group-(P0.05).-The-HDL-C-level-in-nodular-goiter-accompanied-with-gal-stone-group-and-control-group-was-higher-than-that-in-simple-nodular-goiter-group-(P<0.01).-Conclusion:The-originating-etiologic-factor-of-nodular-goiter-accompanied-with-gal-stone-may-be-related-to-that-the-decreased-TT3-induced-sub-clinical-hypothyroidism.

  9. MRI Findings of Coexistence of Ectopic Neurohypophysis, Corpus Callosum Dysgenesis, and Periventricular Neuronal Heterotopia

    Directory of Open Access Journals (Sweden)

    Harun Arslan

    2014-01-01

    Full Text Available Ectopic neurohypophysis is a pituitary gland abnormality, which can accompany growth hormone deficiency associated with dwarfism. Here we present magnetic resonance imaging (MRI findings of a rare case of ectopic neurohypophysis, corpus callosum dysgenesis, and periventricular neuronal heterotopia coexisting, with a review of the literature.

  10. Clinical Pathological Features of Gray Matter Heterotopias%灰质异位的临床病理学特征研究

    Institute of Scientific and Technical Information of China (English)

    冷慧; 付静; 梁乐; 刘瑛

    2016-01-01

    目的:探讨灰质异位病理学诊断的客观依据。方法分析17例灰质异位手术切除标本病理及临床资料,辅以免疫组化方法,计数灰质异位灶中神经元的数量和类型。结果本组病例中灰质异位术前MRI确诊为3例,其余14例(82.4%,14/17)均依靠镜下诊断。大体改变有三型:(1)白质中孤立的皮质样结节;(2)位于皮质下、呈结节状或舌状与皮质相连;(3)大脑皮层增厚,皮白质分界不清。镜下部分灰质异位结节边界清,结节中神经元排列紊乱,无极向,无正常皮质分层结构;神经元可表现退变、坏死、形态不成熟;免疫组化GFAP 可显示部分灰质异位结节的轮廓,神经元核抗原(neuronal nuclei, Ne鄄uN)、微管相关蛋白2,(microtubule associated protein-2, MAP-2)染色显示神经元数量减少且其中不成熟神经元比例增高,差异有显著统计学意义(t=-3.66,P<0.01)。结论灰质异位病变范围广泛时可于影像学检测中发现,但多数的灰质异位诊断仍需依靠病理组织学确诊,免疫组化GFAP有利于观察灰质异位灶形态, NeuN和Map-2强阳性细胞计数能为灰质异位诊断提供客观依据。%Objective To explore the objective basis for the pathological diagnosis of gray matter heterotopia. Methods The pathological and clinical data of 17 cases of gray matter heterotopia resection were analyzed, and supplemented by immunohistochemical method, the number and types of neurons in the gray matter heterotopia were counted. Results Only 3 cases of gray matter heterotopias were diagnosed by MRI before surgery in this group. The remaining 14 cases (82.4%, 14/17) were all diagnosed by microscopic diagnosis. There are three types of gross performance: (1) isolated gray matter nodule in white matter. (2) Gray matter heterotopia is located in the subcortical and show nodular or tongue connected to the cortex. (3) Cerebral cortical is

  11. Tracing Heterotopias: Writing Women Educators in Greece

    Science.gov (United States)

    Tamboukou, Maria

    2004-01-01

    Over the last 15 years, feminist theorists have sought to redefine female subjectivity. Amongst a wide range of critical notions of the female self, this paper focuses on what Foucault has defined as heterotopias, 'different places' which disrupt the dominance of the one single 'real' social place, offering shelter to subjects in crisis. I will…

  12. A Further Education College as a Heterotopia

    Science.gov (United States)

    Blair, Erik

    2009-01-01

    Foucault suggests that there are "other spaces", heterotopias, which are located in the world we live in but are "outside of all places, even though it may be possible to indicate their location in reality". Foucault offers examples of this concept by suggesting that prisons, brothels and boats at sea are specific spaces that are linked to, but…

  13. A Further Education College as a Heterotopia

    Science.gov (United States)

    Blair, Erik

    2009-01-01

    Foucault suggests that there are "other spaces", heterotopias, which are located in the world we live in but are "outside of all places, even though it may be possible to indicate their location in reality". Foucault offers examples of this concept by suggesting that prisons, brothels and boats at sea are specific spaces that…

  14. Different spaces : Exploring Facebook as heterotopia

    NARCIS (Netherlands)

    Rymarczuk, R.; Derksen, Maarten

    2014-01-01

    In this paper we explore the space of Facebook, and use Michel Foucault’s concept of heterotopia to describe it. We show that the heterotopic nature of Facebook explains not only much of its attraction, but even more the discomfort that many people, users as well as non–users, experience in it. Anal

  15. Different spaces : Exploring Facebook as heterotopia

    NARCIS (Netherlands)

    Rymarczuk, R.; Derksen, Maarten

    2014-01-01

    In this paper we explore the space of Facebook, and use Michel Foucault’s concept of heterotopia to describe it. We show that the heterotopic nature of Facebook explains not only much of its attraction, but even more the discomfort that many people, users as well as non–users, experience in it.

  16. Periventricular heterotopia in common microdeletion syndromes.

    NARCIS (Netherlands)

    Kogelenberg, M. van; Ghedia, S.; McGillivray, G.; Bruno, D.; Leventer, R.; Macdermot, K.; Nelson, J.; Nagarajan, L.; Veltman, J.A.; Brouwer, A.P.M. de; McKinlay Gardner, R.J.; Bokhoven, J.H.L.M. van; Kirk, E.P.; Robertson, S.P.

    2010-01-01

    Periventricular heterotopia (PH) is a brain malformation characterised by heterotopic nodules of neurons lining the walls of the cerebral ventricles. Mutations in FLNA account for 20-24% of instances but a majority have no identifiable genetic aetiology. Often the co-occurrence of PH with a

  17. Different spaces : Exploring Facebook as heterotopia

    NARCIS (Netherlands)

    Rymarczuk, R.; Derksen, Maarten

    2014-01-01

    In this paper we explore the space of Facebook, and use Michel Foucault’s concept of heterotopia to describe it. We show that the heterotopic nature of Facebook explains not only much of its attraction, but even more the discomfort that many people, users as well as non–users, experience in it. Anal

  18. STUDY ON MORPHOLOGICAL FEATURES OF NODULAR HIDRADENOMA

    Directory of Open Access Journals (Sweden)

    Pushpa

    2015-06-01

    Full Text Available Study conducted in Government Villupuram medical college about morphological features of nodular hidradenoma by reviewing the hispathology slides of five cases in one year period. Analytical study done regarding the gender, age, and sites distribution of tumour and also variation in gross and histopatholgy features. OBJECTIVE : To describe and study the morphological features of Nodular Hidradenoma along with data on gender and age. Study on Sites and morphological features also included. MATERIALS AND METHOD: Retrospective evaluation of histopathological records duri ng the previous year 2013 - 2014 . The study was conducted in Tertiary care Teaching hospital , Government Villupuram Medical College, Villupuram. 5 cases of nodular hidradenoma were identified. Data on gender, age, C linical presentation, gross and microscopic findings with hematoxylin and eosin stains were collected. Histological slides were reviewed.

  19. Fluorescence immunophenotyping and interphase cytogenetics (FICTION) detects BCL6 abnormalities, including gene amplification, in most cases of nodular lymphocyte-predominant Hodgkin lymphoma.

    Science.gov (United States)

    Bakhirev, Alexei G; Vasef, Mohammad A; Zhang, Qian-Yun; Reichard, Kaaren K; Czuchlewski, David R

    2014-04-01

    BCL6 translocations are a frequent finding in B-cell lymphomas of diverse subtypes, including some cases of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). However, reliable analysis of BCL6 rearrangements using fluorescence in situ hybridization is difficult in NLPHL because of the relative paucity of neoplastic cells. Combined immunofluorescence microscopy and fluorescence in situ hybridization, or fluorescence immunophenotyping and interphase cytogenetics as a tool for the investigation of neoplasms (FICTION), permits targeted analysis of neoplastic cells. To better define the spectrum of BCL6 abnormalities in NLPHL using FICTION analysis. We performed an optimized FICTION analysis of 24 lymph nodes, including 11 NLPHL, 5 follicular hyperplasia with prominent progressive transformation of germinal centers, and 8 follicular hyperplasia without progressive transformation of germinal centers. BCL6 rearrangement was identified in 5 of 11 cases of NLPHL (46%). In addition, BCL6 gene amplification, with large clusters of BCL6 signals in the absence of chromosome 3 aneuploidy, was detected in 3 of 11 cases of NLPHL (27%). One NLPHL showed extra copies of BCL6 present in conjunction with multiple copies of chromosome 3. Altogether, we detected BCL6 abnormalities in 9 of 11 cases of NLPHL (82%). None of the progressive transformation of germinal centers or follicular hyperplasia cases showed BCL6 abnormalities by FICTION. To our knowledge, this is the first report of BCL6 gene amplification in NLPHL. Our optimized protocol for FICTION permits detection of cytogenetic abnormalities in most NLPHL cases and may represent a useful ancillary diagnostic technique.

  20. Ethanol induces heterotopias in organotypic cultures of rat cerebral cortex.

    Science.gov (United States)

    Mooney, Sandra M; Siegenthaler, Julie A; Miller, Michael W

    2004-10-01

    Abnormalities in the migration of cortical neurons to ectopic sites can be caused by prenatal exposure to ethanol. In extreme cases, cells migrate past the pial surface and form suprapial heterotopias or 'warts'. We used organotypic slice cultures from 17-day-old rat fetuses to examine structural and molecular changes that accompany wart formation. Cultures were exposed to ethanol (0, 200, 400 or 800 mg/dl) and maintained for 2-32 h. Fixed slices were sectioned and immunolabeled with antibodies directed against calretinin, reelin, nestin, GFAP, doublecortin, MAP-2 and NeuN. Ethanol promoted the widespread infiltration of the marginal zone (MZ) with neurons and the focal formation of warts. The appearance of warts is time- and concentration-dependent. Heterotopias comprised migrating neurons and were not detected in control slices. Warts were associated with breaches in the array of Cajal-Retzius cells and with translocation of reelin-immunoexpression from the MZ to the outer limit of the wart. Ethanol also altered the morphology of the radial glia. Thus, damage to the integrity of superficial cortex allows neurons to infiltrate the MZ, and if the pial-subpial glial barrier is also compromised these ectopic neurons can move beyond the normal cerebral limit to form a wart.

  1. Ultrasonography of sclerosing angiomatoid nodular transformation in the spleen

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    We report three rare cases of sclerosing angiomatoid nodular transformation(SANT) in the spleen.We compared the conventional and contrast-enhanced ultrasonographic appearance.The conventional sonographic examinations exhibited solitary lesions without common respects,while contrast-enhanced ultrasonography(CEUS) revealed nodular appearance mimicking its pathologic characteristics.It suggests that CEUS can provide morphologic information for diagnosing SANT.

  2. Bilateral subcortical heterotopia with partial callosal agenesis in a mouse mutant.

    Science.gov (United States)

    Rosen, G D; Azoulay, N G; Griffin, E G; Newbury, A; Koganti, L; Fujisaki, N; Takahashi, E; Grant, P E; Truong, D T; Fitch, R H; Lu, L; Williams, R W

    2013-04-01

    Cognition and behavior depend on the precise placement and interconnection of complex ensembles of neurons in cerebral cortex. Mutations that disrupt migration of immature neurons from the ventricular zone to the cortical plate have provided major insight into mechanisms of brain development and disease. We have discovered a new and highly penetrant spontaneous mutation that leads to large nodular bilateral subcortical heterotopias with partial callosal agenesis. The mutant phenotype was first detected in a colony of fully inbred BXD29 mice already known to harbor a mutation in Tlr4. Neurons confined to the heterotopias are mainly born in midgestation to late gestation and would normally have migrated into layers 2-4 of overlying neocortex. Callosal cross-sectional area and fiber number are reduced up to 50% compared with coisogenic wildtype BXD29 substrain controls. Mutants have a pronounced and highly selective defect in rapid auditory processing. The segregation pattern of the mutant phenotype is most consistent with a two-locus autosomal recessive model, and selective genotyping definitively rules out the Tlr4 mutation as a cause. The discovery of a novel mutation with strong pleiotropic anatomical and behavioral effects provides an important new resource for dissecting molecular mechanisms and functional consequences of errors of neuronal migration.

  3. Bilateral periventricular heterotopias in an X-linked dominant transmission in a family with two affected males.

    Science.gov (United States)

    Gérard-Blanluet, Marion; Sheen, Volney; Machinis, Kalotina; Neal, Jason; Apse, Kira; Danan, Claude; Sinico, Martine; Brugières, Pierre; Mage, Katia; Ratsimbazafy, Lanto; Elbez, Annie; Janaud, Jean-Claude; Amselem, Serge; Walsh, Christopher; Encha-Razavi, Férechté

    2006-05-15

    We report on the case of dizygotic twin boys, born prematurely to an asymptomatic mother. Bilateral periventricular heterotopias with enlarged ventricles were discovered at birth in both twins. One of the twins died prematurely of bronchopulmonary complications, and was shown to have several neuropathological anomalies (microgyria, thin corpus callosum, and reduced white matter). The surviving twin had mental retardation, without epilepsy. MRI of the mother showed asymptomatic periventricular heterotopias without ventricular enlargement. She had two affected daughters also with asymptomatic periventricular heterotopias. A point mutation in the last coding exon 48 of the Filamin A (FLNA) gene (7922c > t) was discovered on sequencing and segregated with the affected individuals. This family has a classical X-linked dominant BPNH pathology, with greater severity in males than females. The location of the FLNA mutation is discussed in light of the neuropathological anomalies and mental retardation in male patients.

  4. Unusual Presentation of Multibacillary Nodular Leprosy

    Science.gov (United States)

    Raut, Shweta; Kanade, Swapna; Nataraj, Gita; Mehta, Preeti

    2017-01-01

    Despite India achieving the goal of elimination of leprosy as a public health problem, leprosy is still being transmitted in India. However, due to decreased clinical suspicion of leprosy and atypical case presentations, such cases may be not be diagnosed. We present a case report of an unusual presentation of multibacillary leprosy which presented as nodular lesions. This case report indicates that atypical presentations of leprosy may be missed out by primary care physicians. PMID:28042219

  5. Cerebello-cortical heterotopia in dentate nucleus, and other microdysgeneses in trisomy D1 (Patau) syndrome.

    Science.gov (United States)

    Hori, A; Peiffer, J; Pfeiffer, R A; Iizuka, R

    1980-01-01

    Several new histological findings in six cases of the trisomy D1 syndrome are described: hyperplasia of fetal structures (indusium griseum, median raphe of the medulla oblongata) and completely developed cerebellar cortical heterotopia in the dentate nucleus. In one case, a heterotopic pontine nucleus was found within the cerebellar white matter. The coexistence of overdeveloped and remaining fetal structures is emphasized. Several hypotheses regarding cerebellar dysgenesis are discussed.

  6. Discordant lymphoma consisting of mediastinal large B-cell lymphoma and nodular sclerosis Hodgkin lymphoma in the right supraclavicular lymph nodes: a case report.

    Science.gov (United States)

    Zhang, Chun; Yi, Yuanxue; Chen, Chunyan; Wang, Jianrong; Liu, Zhu

    2015-12-29

    Discordant lymphoma is defined by the simultaneous presence of two or more distinct types of lymphomas at different anatomic sites. With fewer than 20 studies reporting cases of discordant lymphoma to date, the incidence of this condition is believed to be very low. Here, we report a case of discordant lymphoma in a 34-year-old female patient that involved mediastinal large B-cell lymphoma and nodular sclerosis Hodgkin lymphoma in the right supraclavicular lymph nodes. The patient presented with a mass in the mediastinum and enlargement of the right supraclavicular lymph nodes, but no obvious signs of lymphoma. Histological examination revealed that the encapsulated mediastinal mass contained medium- or large-size tumor cells with lightly stained cytoplasm and round vesicular nuclei as well as a high percentage of mitotic cells; strongly positive immunohistochemical staining for PAX5, CD20, and CD79a also was observed. Examination of biopsied right supraclavicular lymph node tissues revealed separation by collagen fibers, extensive inflammatory cell infiltration, and large-size tumor cells, such as Reed-Sternberg cells. These tissues stained strongly positive for PAX5 and CD30, weakly positive for CD15, and negative for Epstein-Barr viral RNA. We also found monoclonal gene rearrangement in the immunoglobulin heavy chain gene in the mediastinal large B-cell lymphoma, but no monoclonal gene rearrangement in the nodular sclerosis Hodgkin lymphoma. These findings suggested that these two lymphomas were not of a common clonal origin. The patient was treated by surgical excision of the mediastinal mass followed by radio-chemotherapy, and no metastasis or recurrence occurred during a follow-up period of 32 months. A review of previously reported cases indicated that the clinical manifestations and pathological features of discordant lymphoma are diverse due to variation in the types of lymphomas involved. Physicians must have an awareness of discordant lymphoma to avoid

  7. Atypical focal nodular hyperplasia of the liver

    Institute of Scientific and Technical Information of China (English)

    Muhammad Rizwan Khan; Taimur Saleem; Tanveer Ul Haq; Kanwal Aftab

    2011-01-01

    BACKGROUND: Focal nodular hyperplasia, a benign hepatic tumor, is usually asymptomatic. However, rarely the entity can cause symptoms, mandating intervention. METHOD: We present a case of focal nodular hyperplasia of the liver, which caused a considerable diagnostic dilemma due to its atypical presentation. RESULTS: A 29-year-old woman presented with a 15-year history of a progressively increasing mass in the right upper quadrant which was associated with pain and emesis. Examination showed a firm, mobile mass palpable below the right subcostal margin. A computed tomography scan of the abdomen showed an exophytic mass arising from hepatic segments III and IVb. Trucut biopsy of the hepatic mass was equivocal. Angiography showed a vascular tumor that was supplied by a tortuous branch of the proper hepatic artery. Surgical intervention for removal of the mass was undertaken. Intra-operatively, two large discrete tumors were found and completely resected. Histopathological examination showed features consistent with focal nodular hyperplasia. CONCLUSION: This description of an unusual case of focal nodular hyperplasia of the liver highlights the point that the diagnosis of otherwise benign hepatic tumors may be difficult despite extensive work-up in some cases.

  8. Heterotopia on Screen- Blue Velvet (1986

    Directory of Open Access Journals (Sweden)

    Filimon Eliza Claudia

    2014-03-01

    Full Text Available Based on a framework consisting of postmodern theories of heterotopias, spatial pastiche, schizophrenic temporality and postmodern speed, this paper seeks to identify cinematic features in the works of the American director David Lynch, which exemplify time and space in postmodernism. Michel Foucault's theory of space will trigger the whole problematic of the time-space relation. This is followed by a discussion of Fredric Jameson's concepts of spatial pastiche and schizophrenic temporality and of the involute interaction between the two

  9. Making Payton's Rocket: Heterotopia and Lines of Flight

    Science.gov (United States)

    MacRae, Christina

    2011-01-01

    This article explores the potential of heterotopia as a way to prompt us to think differently about children's art-making. Foucault uses the term to describe a space of difference. As something that is not easily located within a system of representation, a heterotopia is not amenable to interpretation. It is this resistance to interpretation that…

  10. Complete pancreatic heterotopia of gallbladder with hypertrophic duct simulating an adenomyoma

    Institute of Scientific and Technical Information of China (English)

    Luca Pilloni; Alessandro Cois; Alessandro Uccheddu; Rossano Ambu; Pierpaolo Coni; Gavino Faa

    2006-01-01

    The gallbladder is an unusual location of pancreatic heterotopia, defined as the presence of pancreatic tissue lacking anatomical and vascular continuity with the main body of the gland. A 28-year-old man presented with anorexia, nausea and pain in the right upper abdomen. On physical examination, the abdomen was tender to palpation and Murphy sign was positive. The patient underwent a cholecystecomy. This case, in our opinion,is very interesting since it permits to consider a controversial issue in the pathology of the gallbladder. The histological appearance of ductal structure in pancreatic heterotopia resembles the histological picture of both Aschoff-Rokitansky (AR) sinuses and adenomyomas. This finding suggests that these lesions are linked by a common histogenetic origin. We suggest that the finding of an adenomyoma in the gallbladder should prompt an extensive sampling of the organ in order to verify the coexistence of pancreatic rests.

  11. Intraductal papillary mucinous neoplasm (IPMN) of the gastric-type with focal nodular growth of the arborizing papillae: a case of high-grade transformation of the gastric-type IPMN.

    Science.gov (United States)

    Ban, Shinichi; Naitoh, Yoshihisa; Ogawa, Fumihiro; Shimizu, Yoshihiko; Shimizu, Michio; Yasumoto, Akihiro; Koyama, Isamu

    2006-07-01

    We present a case of intraductal papillary mucinous neoplasm (IPMN) of the pancreas, demonstrating a process of high-grade transformation of the gastric-type IPMN. An 83-year-old Japanese woman underwent pylorus-preserving pancreatoduodenectomy for removal of a multicystic mass of the pancreas head, which had been followed up for 7 years. The removed tumor was a low-grade gastric-type IPMN spreading in the branch ducts, focally forming an intraluminal nodular lesion. The nodular lesion was comprised of arborizing papillotubular proliferation of cuboidal to columnar epithelia with high-grade atypia, and was characterized by diffuse MUC1 expression and a gastric mucin phenotype (focal MUC5AC and MUC6 expressions). Therefore, the nodular lesion was consistent with the pancreatobiliary-type IPMN, and the present case suggests that the low-grade gastric-type IPMN may progress to a focal intraductal carcinoma over the years, and the pancreatobiliary-type IPMN may be one of the forms of such high-grade transformation of the gastric-type IPMN. One of the cystic lesions was an oligocystic-type serous cystic neoplasm (serous cystadenoma), which might be an incidental concomitance or have a common basis.

  12. Nodular fasciitis of the finger

    Energy Technology Data Exchange (ETDEWEB)

    Kijima, Hiroaki; Okada, Kyoji; Ito, Hiroki; Shimada, Yoichi; Itoi, Eiji [Akita University School of Medicine, Department of Orthopedic Surgery, Akita (Japan); Nanjo, Hiroshi [Akita University Hospital, Department of Clinical Pathology, Akita (Japan)

    2005-02-01

    Nodular fasciitis is a benign reactive lesion, often mistaken for a soft tissue sarcoma in clinical practice. Involvement of the finger is very rare and, as a result, in this location the lesion has sometimes been treated by ray amputation because of misdiagnosis. We report on the clinical and histological features of nodular fasciitis in a 30-year-old man who was treated by excisional biopsy. There has been no evidence of local recurrence at the recent follow-up 8 years after surgery. The importance of careful histological examination to avoid radical surgery should be emphasized because marginal excision can provide good results in the treatment of nodular fasciitis. (orig.)

  13. Nodular calcified neurocysticercosis with signs of reactivation

    Energy Technology Data Exchange (ETDEWEB)

    Coeli, Gustavo Nunes Medina; Tiengo, Rodrigo Ribeiro; Silva, Guilherme Carlos da; Silva, Leandro Urquiza Marques Alves da, E-mail: gustavonmc@yahoo.com.br [Department of Radiology and Imaging Diagnosis, Hospital Escola de Itajuba, MG (Brazil); Silva, Afonso Carlos da [Medical Practice, Hospital Escola de Itajuba, MG (Brazil); Fernandes, Jose Otavio Meyer [Clinica Sul Mineira Tomosul and Clinica Magsul, Itajuba, MG (Brazil)

    2012-09-15

    Neurocysticercosis is a disease characterized by the involvement of the central nervous system by the intermediate larval stage of the parasite Taenia solium. The larva degeneration process and the inflammatory reaction of the body cause clinical symptoms. The authors report a case of clinical and radiological reactivation of nodular calcified neurocysticercosis in a patient who was asymptomatic for more than 20 years. Antiparasitic treatment showed a good response (author)

  14. Corymbiform nodular amyloidosis Amiloidose nodular com lesão corimbiforme

    Directory of Open Access Journals (Sweden)

    Sheila Viana Castelo Branco Gonçalves

    2012-10-01

    Full Text Available Amyloidosis is part of a group of deposition diseases. Nodular amyloidosis is a rare form of primary cutaneous amyloidosis. It affects men and women, usually over the age of 60 years. Presenting manifestation of the disease are yellowish-erythematous or brownish nodules or plaques in single or multiple infiltrates. Systemic evaluation should be performed to rule out involvement of other organs. Follow-up of the patient is important because the condition may progress to systemic amyloidosis. We report a case of nodular amyloidosis in which the lesion had a corymbiform aspect without systemic involvement and no recurrence after two years of follow-up.As amiloidoses constituem um grupo de doenças de depósito. A amiloidose nodular é uma forma rara de amiloidose cutânea primária. Acomete homens e mulheres, geralmente acima de 60 anos. Apresenta-se com nódulos ou placas eritemato-amareladas ou acastanhadas infiltradas isoladas ou múltiplas. A avaliação sistêmica deve ser feita para descartar comprometimento de outros órgãos. É importante o seguimento devido a possibilidade de evolução para amiloidose sistêmica. Relatamos um caso de amiloidose nodular com lesão de aspecto corimbiforme sem sistematização e sem recidiva após dois anos de seguimento.

  15. Pancreatic and Gastric Heterotopia with Associated Submucosal Lipoma Presenting as a 7-cm Obstructive Tumor of the Ileum: Resection with Double Balloon Enteroscopy

    Directory of Open Access Journals (Sweden)

    Kun Jiang

    2015-07-01

    Full Text Available Pancreatic and gastric heterotopias are rare clinical entities which have been identified throughout the entire length of the gastrointestinal tract. Combined gastric and pancreatic heterotopias, although unusual, have been described in the duodenum and jejunum, and in other structures, including Meckel's diverticulum and the ampulla of Vater. We report a novel case of pancreatic and gastric heterotopia with an associated submucosal lipoma in a 38-year-old female with a recent history of rectal cancer and chronic crampy abdominal pain. On computed tomography, a 7-cm luminal polypoid mass extending into the distal ileum was discovered. The mass was successfully resected using retrograde double balloon enteroscopy. We believe this is the first report of all three histological entities co-existing in an obstructive ileal lesion in an adult. It highlights endoscopic resection trough double enteroscopy as a safe alternative to more invasive surgical approaches for this type of lesion.

  16. Teaching and Learning Projects as 'Heterotopias'

    Directory of Open Access Journals (Sweden)

    David Gosling

    2014-07-01

    Full Text Available Using the lens of Foucault's ideas about  heterotopias, this paper discusses the Centres for Excellence in Teaching and Learning (CETLs which were teaching and learning projects funded between 2005 and 2010 by the Higher Education Funding Council for England (HEFCE. The paper explores the 'location' of the CETLs in different kinds of real, social and imagined space. This enables an  examination of  the ways in which CETLs were both 'within' and 'without' their institution, both reflecting the institutional culture which created them and yet were also necessarily 'other'.  The paper concludes with some speculation on some characteristics of funded teaching and learning projects in general which are illuminated by the issues the CETLs faced about their location, their place, and their identity.

  17. Heterotopias in Tess of D’Urbervilles

    Institute of Scientific and Technical Information of China (English)

    褚萌萌

    2014-01-01

    Tess of D’Urbervilles is one of the Wessex novels of the late 19th century naturalist writer, Thomas Hardy. The environ-ment description has always been the focus of previous studies and critiques in that it plays a fundamental role in the characteriza-tion and the development of plot. While most of the studies consider the environment as an indicator and catalyst for the protago-nists’tragedy, Foucault’s philosophical theory concerning the Heterotopia actually provides us with a novel insight into the sig-nificance of the environment description in this story. In this perspective, the surroundings are not merely a physical existence en-tirely separated from human perceptive, but rather a synchronic space network where different spaces are intertwined and inter-locked together.

  18. Bilateral Gigantomastia, Multiple Synchronous Nodular Pseudoangiomatous Stromal Hyperplasia Involving Breast and Bilateral Axillary Accessory Breast Tissue, and Perianal Mammary-Type Hamartoma of Anogenital Mammary-Like Glands: A Case Report.

    Science.gov (United States)

    Hayes, Malcolm M; Konstantinova, Anastasia M; Kacerovska, Denisa; Michal, Michal; Kreuzberg, Boris; Suvova, Bozena; Kazakov, Dmitry V

    2016-05-01

    Mammary-type fibroepithelial lesions involving ectopic breast and anogenital region are rare and usually coexist with normal orthotopic breast. We present what we believe to be a unique case of synchronous bilateral gestational gigantomastia resembling fibrous mastopathy, synchronous rapidly growing pregnancy-associated nodular pseudoangiomatous stromal hyperplasia involving right breast and bilateral axillary ectopic breast tissue, and metachronous perianal mammary-type hamartoma involving anogenital mammary-like glands occurring in a 34-year-old patient with facioscapulohumeral muscular dystrophy. Also, we review the literature concerning these lesions.

  19. STRUCTURE OF THE NODULAR GOITER IN CHILDREN

    Directory of Open Access Journals (Sweden)

    O. S. Rogova

    2015-01-01

    Full Text Available For today the question of early diagnosis of nosological variants, the method of treatment and prevention of nodular goiter in children is still not fully resolved. There is a few available literature data about study of this problem in children. Objective: to study morphofunctional structure of thyroid nodules in children.The article provides information consisting of the results of a retrospective analysis of case histories of 73 patients, operated with nodular goiter in Z.A. Bashlyaeva Children’sCityClinicalHospital(Moscow from 2003 to May 2015. The examination included an evaluation of the functional status of the pituitary-thyroid system: there were investigated serum thyroxine, triiodothyronine and thyroid stimulating hor-mone, also was performed thyroid scintigraphy 99mТc. In the postoperative period, there was carried out a final verification of the diagnosis according to the results of the histological conclusion. The histologi-cal type of nodal disease was defined by the WHO classification of 2004. It was established that in the structure of a single-node goiter in children prevail nodular colloid goiter with equal frequency in boys and girls, with the same frequency occurs thyroid adenoma, but more often in girls than in boys. The multinodular goiter equally often detected in girls and boys both nodular goiter colloidal with varying degree of proliferation and colloid in combination with follicular thyroid adenoma. "Hot" nodes in the multinodular goiter are more common than in the single-node goiter and more fre-quently in girls than in boys. The half of children with nodular pathology have "hot" nodes and one out of every three – decompensated form of functional autonomy. Decompensated form of functional autonomy of the thyroid gland in children with "hot" nodes detects regardless of the number of nodes. Papillary thyroid cancer occurs not only in patients with a single-node, but with a multinodular goiter. The results allow to

  20. Treatment of nodular vasculitis based on syndrome differentiation: A report of 32 cases%辨证论治32例结节性血管炎

    Institute of Scientific and Technical Information of China (English)

    何敢想

    2003-01-01

    @@ 结节性血管炎(nodular vasculitis)是一种较常见的小血管炎性疾病.其主要特征为下肢非对称性疼痛性结节,以小腿部多见,好发于30~40岁妇女,属于中医"瘀血流注"、"梅核丹"范畴.笔者运用辨证论治方法,治疗32例结节性血管苘炎,取得了较好效果.现报道如下.

  1. Nodular hidradenoma of the caruncle

    DEFF Research Database (Denmark)

    Christakopoulos, Christos; Prause, Jan Ulrik; Heegaard, Steffen

    2013-01-01

    . Immunohistochemical staining of the tumor cells demonstrated positive staining with antibodies against CK-CAM 5.2, BER-EP4, p63, and smooth muscle actin-positive cells in some areas. The tumor was diagnosed as a nodular hidradenoma of the caruncle, which has never been reported before and should be included...

  2. Malignant nodular hidradenoma of scalp

    Directory of Open Access Journals (Sweden)

    Tanmoy Maiti

    2014-01-01

    Full Text Available Malignant nodular hidradenoma (MNH is a rare tumor of sweat gland known by many names in the literature. Scalp is a known and yet uncommon site of occurrence. We describe two patients with scalp MNH with brain parenchymal invasion. Both tumors recurred in spite of total excision and radiotherapy.

  3. No-Needle Jet Intradermal Aminolevulinic Acid Photodynamic Therapy for Recurrent Nodular Basal Cell Carcinoma of the Nose: A Case Report

    Directory of Open Access Journals (Sweden)

    Daniel Barolet

    2011-01-01

    Full Text Available Photodynamic therapy (PDT with aminolevulinic acid (ALA to treat nodular basal cell carcinoma (BCC has been shown to be beneficial. The success rate of ALA-PDT in the treatment of nodular BCC is dependent on optimal penetration of the photosensitizing agent and subsequent PpIX production. To enhance topical delivery of drugs intradermally, a needleless jet injection (NLJI, which employs a high-speed jet to puncture the skin without the side effects of needles, was used in one patient with recurrent BCC of the nose. Photoactivation was then performed using red light emitting diode [CW @ λ 630 nm, irradiance 50 mW/cm2, total fluence 51 J/cm2] for 17 minutes. Excellent cosmesis was obtained. Aside from mild crusting present for six days, no other adverse signs were noted. Clinically, there was no recurrent lesion up two years postintervention. Additional studies in larger samples of subjects are needed to further evaluate this promising technique.

  4. Nodular Corrosion Characteristics of Zirconium Alloys

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyun Gil; Jeong, Y. H.; Park, S. Y.; Lee, D. J

    2003-01-15

    This study was reported the effect of the nodular corrosion on the nuclear reactor environmental along with metallurgical influence, also suggested experimental scheme related to evaluate nodular corrosion characteristics of Zr-1 Nb alloy. Remedial strategies against the nodular corrosion should firstly develop plan to assess the effect of the water quality condition (Oxygen, Hydrogen) as well as the boiling on the nodular corrosion, secondarily establish plan to control heat treatment process to keep a good resistance on nodular corrosion in Zr-1Nb alloy as former western reactor did.

  5. THE INCIDENCE OF THYROID MALIGNANCY IN NODULAR GOITER: A RETROSPECTIVE ANALYSIS IN A MEDICAL COLLEGE HOSPITAL

    Directory of Open Access Journals (Sweden)

    Praveen Kumar

    2015-09-01

    Full Text Available The incidence of malignancy in nodular goiter has been found to vary from 4% to 17%. Our aim is to determine the incidence of malignancy in nodular goiter by doing the histopathological examination of thyroidectomy specimens. MATERIALS AND METHODS: This retrospective, observational study was carried out on patients who are undergone thyroidectomy for clinically diagnosed nodular goiter in Fr . Muller Medical College Hospital during 2012 - 2014 (3 yrs. All the operated specimens were subjected to a histopathological examination to determine the incidence of malignancy. RESULTS: Among the 258 nodular goitre cases which were studied, 21 (8.1% cases contained malignant foci. Among them, papillary carcinoma was the most common type of malignancy observed. CONCLUSION: The risk of malignancy in nodular goitre should not to be underestimated. Total/ Near - total thyroidectomy is the preferred operation. All the operated specimens should be sent for histopathological examination

  6. Winer’s Nodular Calcinosis Mimicking Squamous Cell Carcinoma On The Ear

    Directory of Open Access Journals (Sweden)

    Emine Çiğdem Karadağ

    2017-06-01

    Full Text Available Winer’s nodular calcinosis, presenting as an asymptomatic, firm, white, or yellow nodule at birth or during early childhood, is a form of idiopathic calcinosis cutis. Ulceration on Winer’s nodular calcinosis is rarely seen. Till date, there is no report in the literature regarding the malignant skin lesion confused with Winer’s nodular calcinosis. No similar case or article has been encountered in the Turkish or English literature regarding the malignant skin lesion that might be confused with Winer’s nodular calcinosis. The case of a 3-year-old girl with a 3×2 mm, white, ulcerated, nodular lesion on the helix of the left ear is presented here. The lesion was thought to be a squamous cell carcinoma due to the ulceration and appearance, and it was located on the ear, which is frequently exposed to the sun.

  7. Nodular Fasciitis of the Breast

    Directory of Open Access Journals (Sweden)

    Moghimi

    2016-01-01

    Full Text Available Nodular fasciitis of the breast is a rare benign pathology of soft tissue that is a consequence of fibroblastic hyperplasia within breast. It can mimic breast cancer clinically, radiologically, and histopathologically. A-43 year-old female with a painless mass within upper-lateral quadrant of her left breast complained of rapid and progressive growth during previous few days. No evidence of nipple discharge or sensation of pain was expressed. The mass was tender to palpation, but the size was too tiny to detect. The definitive diagnosis was established with sonography, which detected a hypoechogenic lesion, 10 mm in diameter. The excisional biopsy delivered a tissue composed of fusiform fibroblastic cells with bright ellipsoid-like nuclei and elevated nucleolus. Mitotic formations were also obvious. Low cellular and high cellular zones with hyaline fibrosis and erythrocyte accumulation existed, as well as a light lymphocytic infiltration. All of these features, in addition to adipocytic accumulation within the margins of this lesion, suggested a definitive diagnosis of Nodular fasciitis. The diagnosis of nodular fasciitis is difficult and often is indiscriminable from breast cancer, so paying close attention to this matter is critical.

  8. Heterotopia and Its Role in the Lived Experiences of Resettlement

    Science.gov (United States)

    Rossetto, Marietta

    2006-01-01

    Place, as a metaphor, can be experienced in different ways, existing or created. If created, space can be Foucault's "placeless place", a utopia. A place that exists, however, can be a heterotopic space. A heterotopia is what we as individuals interpret it to be: it can be a space for reconstituting the self, rewriting the scripts of identity and…

  9. Neuropsychological Profile of Children with Subcortical Band Heterotopia

    Science.gov (United States)

    Spencer-Smith, Megan; Leventer, Richard; Jacobs, Rani; De Luca, Cinzia; Anderson, Vicki

    2009-01-01

    Aim: Subcortical band heterotopia (SBH) or "double cortex" is a malformation of cortical development resulting from impaired neuronal migration. So far, research has focused on the neurological, neuroimaging, and genetic correlates of SBH. More recently, clinical reports and small sample studies have documented neuropsychological dysfunction in…

  10. A Heterotopology of the Academy: Mapping Assemblages as Possibilised Heterotopias

    Science.gov (United States)

    Charteris, Jennifer; Jones, Marguerite; Nye, Adele; Reyes, Vicente

    2017-01-01

    Heterotopias are counter-sites of enacted utopias through which reality is simultaneously represented, contested and inverted. They are physical or mental spaces where, although norms of behaviours are suspended, there are connections with a plethora of other spaces. This article constructs a collective biography as a heterotopology of the…

  11. Focal nodular hyperplasia of the liver: an unusual association with diabetes mellitus in a child and review of literature

    Directory of Open Access Journals (Sweden)

    Trizzino Antonino

    2010-05-01

    Full Text Available Abstract Hepatic hemangioma, adenoma and focal nodular hyperplasia are the most frequent benign lesions of the liver, but they are all infrequent among pediatric population. The reports of focal nodular hyperplasia in children have recently increased in number, with many cases associated to drug intake, particularly to chemotherapy. We here describe, to our knowledge, the first case of focal nodular hyperplasia in association with diabetes mellitus in childhood.

  12. Periorbital nodular fasciitis arising during pregnancy

    Directory of Open Access Journals (Sweden)

    Brandon N Phillips

    2014-01-01

    Full Text Available Nodular fasciitis (NF is a benign proliferation of fibroblasts and myofibroblasts that rarely occurs in the periorbital region. We report what we believe to be the first case of periorbital NF associated with pregnancy. A case of intravascular fasciitis, a NF variant, has been reported during pregnancy, but it was not located in the periorbital region. A weak presence of estrogen receptors has been reported in NF. This may make it more susceptible to the hormone-related changes during pregnancy and contribute to the development of the lesion by stimulating fibroblasts and smooth muscle cell types. Although rare, NF should be considered in the differential diagnosis of periorbital soft-tissue masses arising during pregnancy.

  13. Nodular lesions and mesangiolysis in diabetic nephropathy.

    Science.gov (United States)

    Wada, Takashi; Shimizu, Miho; Yokoyama, Hitoshi; Iwata, Yasunori; Sakai, Yoshio; Kaneko, Shuichi; Furuichi, Kengo

    2013-02-01

    Diabetic nephropathy is a leading cause of end-stage renal failure all over the world. Advanced human diabetic nephropathy is characterized by the presence of specific lesions including nodular lesions, doughnut lesions, and exudative lesions. Thus far, animal models precisely mimicking advanced human diabetic nephropathy, especially nodular lesions, remain to be fully established. Animal models with spontaneous diabetic kidney diseases or with inducible kidney lesions may be useful for investigating the pathogenesis of diabetic nephropathy. Based on pathological features, we previously reported that diabetic glomerular nodular-like lesions were formed during the reconstruction process of mesangiolysis. Recently, we established nodular-like lesions resembling those seen in advanced human diabetic nephropathy through vascular endothelial injury and mesangiolysis by administration of monocrotaline. Here, in this review, we discuss diabetic nodular lesions and its animal models resembling human diabetic kidney lesions, with our hypothesis that endothelial cell injury and mesangiolysis might be required for nodular lesions.

  14. Bronquiolite obliterante na forma nodular Bronchiolitis obliterans in nodular form

    Directory of Open Access Journals (Sweden)

    PAULO DE ALMEIDA

    2002-11-01

    Full Text Available Paciente com 54 anos, do sexo feminino, ex-tabagista, que após duas semanas de um resfriado comum procurou atendimento médico devido a tosse com expectoração amarela, obstrução nasal e desconforto facial. Sua radiografia do tórax mostra lesão nodular no lobo superior esquerdo compatível com nódulo pulmonar solitário. Submetida a uma toracotomia exploradora, foi estabelecido o diagnóstico de bronquiolite obliterante com pneumonia em organização (BOOP.A 54 year old female patient, public servant, ex-smoker, after two weeks of a common cold complained of cough with yellow sputum, nasal obstruction and facial pain. A chest X-ray showed a solitary nodular lesion in the upper left lobe. The patient was submitted to a left thoracotomy, which established the diagnosis of bronchiolitis obliterans organizing pneumonia (BOOP.

  15. Intraneural nodular fasciitis of the radial nerve with rapidly progressive motor symptoms

    Directory of Open Access Journals (Sweden)

    Swetha J Sundar

    2016-01-01

    Conclusion: The authors report the first case of intraneural nodular fasciitis occurring in the radial nerve and highlight the possibility of rapidly progressive motor deficit in patients presenting with this rare clinical entity.

  16. Syariah as Heterotopia: Responses from Muslim Women in Aceh, Indonesia

    Directory of Open Access Journals (Sweden)

    Reed Taylor

    2015-05-01

    Full Text Available In this paper, I argue that the implementation of syariah is best understood as a heterotopia by women in Aceh, Indonesia. The current debates over the role of syariah for women in Acehnese society focus on either a secular human rights critique of non-liberal norms that restrict the rights and freedom of women or a religiously prescribed defense of communal norms that protect women and society. Based on interviews, I identify three variants of how women conceive of and inhabit syariah in Aceh. Two of these variants are underrepresented in the current academic literature on syariah in Aceh. Two key distinctions are drawn between blueprint and iconoclastic utopian thought and state-centric and non-state-centric models of political legitimacy. Rethinking syariah as a “socio-spatial dialectic” allows for all three variants of syariah existing simultaneously as a heterotopia in Acehnese society.

  17. Heterotopic neurogenesis in a rat with cortical heterotopia.

    Science.gov (United States)

    Lee, K S; Collins, J L; Anzivino, M J; Frankel, E A; Schottler, F

    1998-11-15

    Early cellular development was studied in the neocortex of the tish rat. This neurological mutant is seizure-prone and displays cortical heterotopia similar to those observed in certain epileptic patients. The present study demonstrates that a single cortical preplate is formed in a typical superficial position of the developing tish neocortex. In contrast, two cortical plates are formed: one in a normotopic position and a second in a heterotopic position in the intermediate zone. As the normotopic cortical plate is formed, it characteristically separates the subplate cells from the superficial Cajal-Retzius cells. In contrast, the heterotopic cortical plate is not intercalated between the preplate cells because of its deeper position in the developing cortex. Cellular proliferation occurs in two zones of the developing tish cortex. One proliferative zone is located in a typical position in the ventricular/subventricular zone. A second proliferative zone is located in a heterotopic position in the superficial intermediate zone, i.e., between the two cortical plates. This misplaced proliferative zone may contribute cells to both the normotopic and heterotopic cortical plates. Taken together, these findings indicate that misplaced cortical plate cells, but not preplate cells, comprise the heterotopia of the tish cortex. Heterotopic neurogenesis is an early developmental event that is initiated before the migration of most cortical plate cells. It is concluded that misplaced cellular proliferation, in addition to disturbed neuronal migration, can play a key role in the formation of large cortical heterotopia.

  18. NEURONS COMPRISING A HETEROTOPIA INDUCED BY DEVELOPMENTAL HYPOTHYROIDISM ARE BORN LATE IN GESTATION.

    Science.gov (United States)

    We previously described an abnormal cluster of neurons, a heterotopia, located in the corpus callosum in rat pups born to dams exposed to the goitrogen, propylthiouracil (PTU, Goodman et al., SfN 2004). In this study we determined 1) whether the formation of the heterotopia was u...

  19. A Doubled Heterotopia: Shifting Spatial and Visual Symbolism in the Jewish Museum Berlin's Development

    Science.gov (United States)

    Saindon, Brent Allen

    2012-01-01

    This essay considers the rhetoric of space in a rapidly transforming culture. Using Michel Foucault's concept of "heterotopias" to understand the rhetorical power of a building's disposition, it is argued that the Jewish Museum Berlin contains two heterotopias, one within the other. The first is Daniel Libeskind's original building design in…

  20. Subcortical laminar heterotopia in two sisters and their mother : MRI, clinical findings and pathogenesis

    NARCIS (Netherlands)

    van der Valk, PHM; Snoeck, [No Value; Meiners, LC; des Portes, [No Value; Chelly, J; Pinard, JM; Ippel, PF; van Nieuwenhuizen, O

    1999-01-01

    MR imaging, clinical data and underlying pathogenesis of subcortical laminar heterotopia (SCLH), also known as band heterotopia, in two sisters and their mother are presented. On MR imaging a different degree of SCLH was found in all three affected family-members. The inversion recovery sequence was

  1. A Doubled Heterotopia: Shifting Spatial and Visual Symbolism in the Jewish Museum Berlin's Development

    Science.gov (United States)

    Saindon, Brent Allen

    2012-01-01

    This essay considers the rhetoric of space in a rapidly transforming culture. Using Michel Foucault's concept of "heterotopias" to understand the rhetorical power of a building's disposition, it is argued that the Jewish Museum Berlin contains two heterotopias, one within the other. The first is Daniel Libeskind's original building…

  2. A Doubled Heterotopia: Shifting Spatial and Visual Symbolism in the Jewish Museum Berlin's Development

    Science.gov (United States)

    Saindon, Brent Allen

    2012-01-01

    This essay considers the rhetoric of space in a rapidly transforming culture. Using Michel Foucault's concept of "heterotopias" to understand the rhetorical power of a building's disposition, it is argued that the Jewish Museum Berlin contains two heterotopias, one within the other. The first is Daniel Libeskind's original building…

  3. Diffuse Nodular Lymphoid Hyperplasia of the Intestine Caused by Common Variable Immunodeficiency and Refractory Giardiasis.

    Science.gov (United States)

    Choi, Jung Hye; Han, Dong Soo; Kim, Jieun; Yi, Kijong; Oh, Young-Ha; Kim, Yongsoo

    2017-01-01

    Diffuse nodular lymphoid hyperplasia of the gastrointestinal tract is a rare disease characterized by numerous small polypoid nodules in the small intestine, large intestine, or both. It is associated with immunodeficiency and infection, such as Giardia lamblia and Helicobacter pylori. Although diffuse nodular lymphoid hyperplasia associated with common variable immunodeficiency (CVID) and giardiasis is already known, a few studies have reported a regression of the lymphoid nodules after the eradication of infection. We herein describe a case of diffuse nodular lymphoid hyperplasia of the intestine associated with CVID and refractory giardiasis that markedly improved after successfully treating giardiasis.

  4. Comparison of computed tomography features between follicular neoplasm and nodular hyperplasia.

    Science.gov (United States)

    Lee, Kwang Hwi; Kim, Dong Wook; Baek, Jin Wook; Lee, Yoo Jin; Choo, Hye Jung; Cho, Young Jun; Lee, Sun Joo; Park, Young Mi; Jung, Soo Jin; Baek, Hye Jin

    2016-10-03

    To date, appropriate management for Bethesda IV thyroid nodules is controversial, and no specific features of follicular neoplasm and nodular hyperplasia on ultrasonography, computed tomography (CT), or other imaging modalities have been reported. This study aimed to compare CT features of follicular neoplasm and nodular hyperplasia and to determine the specific CT features that could be used to distinguish follicular neoplasm from nodular hyperplasia. In 122 patients who underwent preoperative CT of the neck and thyroid surgery, 59 follicular neoplasms and 65 nodular hyperplasias were included. In each case, non-enhanced and contrast-enhanced CT images were obtained, and a single radiologist retrospectively analyzed CT images, including degree and pattern of attenuation, nodular configuration, margin, shape, pattern of calcification, degree and pattern of nodular enhancement, and CT halo sign. A univariate and multivariate logistic regression analyses were used to evaluate the predictive power of each variable and CT features with a high predictive power, respectively. According to the univariate analysis, iso-attenuation, intraglandular configuration, smooth margin, ovoid shape, decreased enhancement, and absence of CT halo sign were more frequently observed in nodular hyperplasia (p hyperplasia (p hyperplasia. Rretrospectively registered.

  5. Nodular glomerulosclerosis in a non-diabetic hypertensive smoker with dyslipidemia Glomeruloesclerosis nodular en un tabaquista hipertenso no-diabético con dislipidemia

    Directory of Open Access Journals (Sweden)

    A.F. Predosa

    2011-08-01

    Full Text Available Nodular glomerulosclerosis may be idiopathic or develop associated with diabetes mellitus, membranoprolipherative glomerulonephritis, light or heavy chain deposits, amyloidosis, fibrillary or immunotactoide disease, and Takayasu's arteritis. Histological features of idiopathic nodular glomerulosclerosis are similar to the Kimmelstiel-Wilson changes. Recent evidence points to the role of hyperglycemia, hyperlipidemia, hypertension and smoking in the mechanisms of this uncommon condition. The case study of a 65-year-old male presenting recent arterial hypertension and nodular non-diabetic glomerulosclerosis is described, and the possible role of heavy smoking in the pathogenesis of this condition is emphasized.La glomeruloesclerosis nodular puede ser idiopática o desarrollarse asociada con diabetes mellitus, glomerulonefritis membranoproliferativa, depósitos de cadenas leves o pesadas, amiloidosis, enfermedad fibrilar o inmmunotactoide, y arteritis de Takayasu. Los aspectos histológicos de la glomeruloesclerosis nodular idiopática son similares a las alteraciones de Kimmelstiel-Wilson. Recientes evidencias indican el papel de la hiperglicemia, la hiperlipidemia, la hipertensión y el tabaquismo en los mecanismos de esta entidad rara. Se presenta el estudio del caso de un hombre con 65 años que presentó hipertensión arterial reciente y glomeruloesclerosis nodular no diabética, y se da énfasis al posible papel de excesivo tabaquismo en la patogénesis de esta condición.

  6. Localized nodular synovitis of the infrapatellar fat pad

    Directory of Open Access Journals (Sweden)

    Jong-Hoon Park

    2013-01-01

    Full Text Available We report a case of localized nodular synovitis of the infrapatellar fat pad impinging on the patellofemoral joint causing limitation of extension. Arthroscopy involved use of a superolateral portal because location of lesion hindered access via a conventional anterior portal. The infrapatellar mass impinged in the patellofemoral joint upon knee extension and retracted upon flexion. Superior-superior triangulation allowed for complete excision of the mass.

  7. A case of composite classical and nodular lymphocyte predominant Hodgkin lymphoma with progression to diffuse large B-cell non-Hodgkin lymphoma: Diagnostic difficulty in fine-needle aspiration cytology.

    Science.gov (United States)

    Das, Dilip K; Sheikh, Zafar A; Al-Shama'a, Mariam H; John, Bency; Alawi, Abdulla M S; Junaid, Thamradeen A

    2017-03-01

    A small percentage of nodular lymphocytic predominant Hodgkin lymphoma (NLPHL) progresses to diffuse large B-cell lymphoma (DLBCL). There have also been rare reports of gray zone lymphoma with features intermediate between classical Hodgkin lymphoma (CHL) and DLBCL. We report a very rare case of composite lymphoma (CHL and NLPHL) progressing to DLBCL, and highlight the diagnostic difficulty faced during its fine-needle aspiration (FNA) cytology diagnosis. A 65-year-old woman presented with a right axillary swelling which was subjected to FNA cytology. The routine FNA cytology diagnosis was anaplastic large cell lymphoma (ALCL) but immunocytochemistry did not support this diagnosis completely. The histopathological diagnosis of the excised lymph node was NLPHL with progression to DLBCL in our hospital but in a hospital abroad where the patient was treated, the reviewed diagnosis was CHL. The patient had a rapid downhill course with development of terminal pleural effusion and died approximately one year from initial diagnosis.The review of the cyto-histologic material along with additional immunocyto/histochemical studies and the clinical course of the disease support the diagnosis of a composite lymphoma (CHL and NLPHL) with progression to DLBCL. It is suggested that all the three lesions were clonally related. Diagn. Cytopathol. 2017;45:262-266. © 2016 Wiley Periodicals, Inc.

  8. Neuronal Heterotopias Affect the Activities of Distant Brain Areas and Lead to Behavioral Deficits.

    Science.gov (United States)

    Ishii, Kazuhiro; Kubo, Ken-ichiro; Endo, Toshihiro; Yoshida, Keitaro; Benner, Seico; Ito, Yukiko; Aizawa, Hidenori; Aramaki, Michihiko; Yamanaka, Akihiro; Tanaka, Kohichi; Takata, Norio; Tanaka, Kenji F; Mimura, Masaru; Tohyama, Chiharu; Kakeyama, Masaki; Nakajima, Kazunori

    2015-09-01

    Neuronal heterotopia refers to brain malformations resulting from deficits of neuronal migration. Individuals with heterotopias show a high incidence of neurological deficits, such as epilepsy. More recently, it has come to be recognized that focal heterotopias may also show a range of psychiatric problems, including cognitive and behavioral impairments. However, because focal heterotopias are not always located in the brain areas responsible for the symptoms, the causal relationship between the symptoms and heterotopias remains elusive. In this study, we showed that mice with focal heterotopias in the somatosensory cortex generated by in utero electroporation exhibited spatial working memory deficit and low competitive dominance behavior, which have been shown to be closely associated with the activity of the medial prefrontal cortex (mPFC) in rodents. Analysis of the mPFC activity revealed that the immediate-early gene expression was decreased and the local field potentials of the mPFC were altered in the mice with heterotopias compared with the control mice. Moreover, activation of these ectopic and overlying sister neurons using the DREADD (designer receptor exclusively activated by designer drug) system improved the working memory deficits. These findings suggest that cortical regions containing focal heterotopias can affect distant brain regions and give rise to behavioral abnormalities. Significance statement: Recent studies reported that patients with heterotopias have a variety of clinical symptoms, such as cognitive disturbance, psychiatric symptoms, and autistic behavior. However, the causal relationship between the symptoms and heterotopias remains elusive. Here we showed that mice with focal heterotopias in the somatosensory cortex generated by in utero electroporation exhibited behavioral deficits that have been shown to be associated with the mPFC activity in rodents. The existence of heterotopias indeed altered the neural activities of the mPFC, and

  9. Nodular Melanoma Mimicking Keratoacanthoma; Lessons to learn

    Directory of Open Access Journals (Sweden)

    Leelavathi Muthupalaniappen

    2012-07-01

    Full Text Available A 67-year-old man of Chinese descent presented with a painless nodular lesion that had been present on his right forearm for the previous 3 months. A single, well-defined, dome-shaped, firm nodule with a central keratin plug surrounded by erythema was noted. Keratoacanthoma with secondary bacterial infection was suspected and the patient underwent an excision biopsy. Biopsy of the nodule and immunohistochemical staining supported a diagnosis of nodular malignant melanoma. It should be noted both that nodular malignant melanoma may present with a wide variety of clinical appearances, and that the lack of melanin pigment in nodular malignant melanoma may hinder the diagnosis of this aggressive tumour.

  10. Mechanism of the Forming of Nodular Graphite

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    This article presents a theory about the growth mechanism of bubble-screw dislocation of nodular graphite. Normally speaking, the crystallizing procedure of most nodular graphite is as follows: firstly, graphite generates nuclei on bubbles and fills them (mainly in the way of screw dislocation) forming the complete nuclei of nodular graphite-graphite bubble nuclei. Then, graphite grows up in the way of screw dislocation. Two important conditions concerning the production of nodular graphite are: (a) there is a relatively big interfacial energy between ferro liquid and graphite, and the one between ferro liquid and graphite prismatic plane is bigger than that between ferro liquid and graphite basal plane; (b) there are a certain amount of micro-bubbles in the melt.

  11. Relapse of leprosy presenting as nodular lymph node swelling

    Directory of Open Access Journals (Sweden)

    Kiran K

    2009-01-01

    Full Text Available Lymphadenopathy is known to be associated with lepromatous leprosy and has also been observed as a feature of type-2 lepra reaction. However, nodular lymph node enlargement is not commonly reported in leprosy patients or as a feature of relapse. We herewith are presenting a case of bacteriological relapse in a patient of lepromatous leprosy treated 22 years before till smear negativity with WHO multidrug therapy (MDT multibacillary type (MB. She presented with prominent nodular swelling of the cervical group of lymph nodes along with generalized lymphadenopathy, which was mistakenly treated as tubercular lymphadenopathy. A diagnosis of late bacteriological relapse of lepromatous leprosy presenting with prominent lymphadenopathy and ENL was made after relevant investigations. The patient was started on treatment with WHO MDT MB (daily dapsone and clofazimine and monthly rifampicin and thalidomide (200 mg/day. Nerve pain regressed within 2 weeks of therapy. The lymph nodal swelling regressed within 3 months of starting treatment.

  12. A nodular-ulcerative form of secondary syphilis in AIDS

    Science.gov (United States)

    Owen, Benjamin D.; Balavenkataraman, Arvind; Weinstein, Mitchell R.

    2017-01-01

    An uncommon variant in the pre-AIDS era, lues maligna is a nodular-ulcerative form of secondary syphilis. We present a case of a 41-year-old man with HIV infection who developed fever, chills, nausea, vomiting, right upper quadrant abdominal pain, weight loss, watery diarrhea, and a painless, nonpruritic rash. He had diffuse nodular-ulcerative lesions in various stages of development. He was found to have a CD4 count of 101 cells/mm3 (22%), an HIV viral load of 2,735,060 copies/mL, and a positive rapid plasma reagin at 1:64. He was started on emtricitabine, tenofovir, and dolutegravir, as well as doxycycline. He was given benzathine penicillin 2.4 million units intramuscularly and within hours developed a Jarisch-Herxheimer reaction. Skin lesions showed signs of healing, and constitutional symptoms improved 48 hours later. PMID:28127144

  13. Nodular Fasciitis of Neck in Childhood.

    Directory of Open Access Journals (Sweden)

    Saurabh Varshney

    2013-01-01

    Full Text Available Nodular fasciitis, is a benign, pseudo sarcomatous proliferative lesion of the soft tissue, which is frequently misinterpreted as sarcoma, both clinically and microscopically. It is a reactive lesion composed of fibroblasts/myofibroblasts and most commonly found in extremities and trunk. NF has been described in the head and neck region in 10-20% of cases. Many pathologists do not consider NF in the differential diagnosis of soft tissue masses arising in the Head neck region. NF that occurs in otherwise healthy individuals usually presents with a history of rapid growth, and is commonly found in the upper extremities and on the chest and trunk. The importance of otolaryngologists being aware of the existence of this entity in this area of the body is stressed. It has a confirmed perfectly benign clinical course, and simple excision, as tissue-sparing as possible, is the treatment of choice. A case of NF over the neck in a 05-year-old female not associated with trauma who presented with a localized mass over her left neck is presented.

  14. Postoperative recurrent nontoxic nodular (multinodular goiter

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    Tolstokorov A.S.

    2011-12-01

    Full Text Available The extensive use of modern methods of examination (ultrasound investigation with Doppler mapping, aspiration (needle biopsy, radiodiagnostics cannot resolve the problem of verification of nodular mass in case of multinodular goiter before operation. Operative intervention is the method of choice in this case, which gives rise to the problem of surgery extent. The present study is useful in improvement of remote results of surgical treatment of multinodular goiter through statistical estimation of recurrent goiter development. The study was retrospective and included 102 consecutively admitted and operated patients with recurrent goiter and 102 patients of control group with first diagnosed and operated goiter. Patients of both groups were in euthyroid state. Patients were admitted to the Clinic of Surgery and Oncology of Raising Skills Faculty of Saratov State Medical University n.a. V. I. Razumovsky from 2000 till 2004. Statistical analyses included calculation of average mean, standard deviation and mean error. Student's ratio was used as the test of validity of average mean. Chi-square test was used for assessment of qualitative characteristics.

  15. The role of sitting-up-straight position on correction of PICC heterotopia%端坐位在PICC导管异位调整正位中的作用

    Institute of Scientific and Technical Information of China (English)

    黄小梅; 李瑛珊; 温盛瑛

    2013-01-01

    目的:探讨端坐位在经外周静脉置入中心静脉导管(peripherally inserted central catheter,PICC)异位调整正位中的作用。方法对18例PICC导管异位的患者,采取端坐位进行调整正位。结果18例患者PICC导管异位均成功正位。结论取端坐位可有效纠正PICC导管异位,此方法操作简单易行,值得临床推广应用。%Objective To investigate the role of sitting-up-straight position in correction of peripherally inserted central catheter(PICC)heterotopia.Method Eighteen cases with PICC heterotopia were instructed to take the position of sitting up straight. Result All of the patients had the PICC heterotopia corrected.Conclusions The sitting-up-straight position can effectively correct the PICC catheter heterotopia.This method is simple and feasible and thus worthy of clinical application.

  16. Imiquimod 5% cream in the treatment of superficial and nodular basal cell carcinomas: study of 10 cases Tratamento tópico do carcinoma basocelular superficial e nodular pelo imiquimod creme a 5%: observação de 10 casos

    Directory of Open Access Journals (Sweden)

    Cyro Festa Neto

    2002-12-01

    Full Text Available BACKGROUND: Topical treatment with 5% imiquimod cream has been demonstrated to be effective in patients with basal cell carcinoma. OBJECTIVES: In the present study, efficacy and tolerability of this treatment was analyzed in 10 patients with 13 different types of superficial and nodular basal cell carcinomas. METHODS: Imiquimod cream was applied daily for a mean period of 23 days. RESULTS AND CONCLUSIONS: All patients responded favorably to the drug with healing of the lesions. No recurrence was observed during two to three months of follow up.FUNDAMENTOS: O uso tópico do imiquimod 5% em creme para o tratamento de carcinomas basocelulares tem-se mostrado eficaz. OBJETIVOS: Com base nesse fato o autor analisa a efetividade e tolerabilidade desse método em 10 doentes com 13 carcinomas basocelulares dos tipos superficial e nodular. MÉTODOS: As aplicações foram diárias, e o número médio de dias de tratamento foi 23. RESULTADOS E CONCLUSÕES: Todos os doentes responderam à medicação com desaparecimento das lesões e são seguidos a cada dois ou três meses, até o momento sem recidiva do quadro.

  17. Sclerosing angiomatoid nodular transformation of spleen:a report of one case and literature review%脾脏硬化性血管瘤样结节性转化一例并文献复习

    Institute of Scientific and Technical Information of China (English)

    汪兵; 史良会

    2016-01-01

    Objective To explore the diagnoses, differential diagnosis and therapy of sclerosing angiomatoid nodular transformation to help us to deepen the understanding of it. Methods The clinical manifestations, pathology, expression of immunohistochemistry, and the follow up of 1 case of SANT was analyzed, and the related literature was reviewed. Results SANT was a rare disease which was reported recent years. Because of lacking characteristic clinical course and radiologic features, it was often misdiagnosed, histological appearance and immunohistochemical staining were essential to clarify the diagnosis. Conclusion SANT is a benign change in the spleen, which has a favourable prognosis and can be cured by splenectomy.%目的:探讨脾脏硬化性血管瘤样结节性转化(SANT)的诊断、鉴别诊断及治疗,提高对 SANT 的认识,避免误诊。方法对1例 SANT 患者的临床、病理特征、免疫组化表达及术后随访情况进行分析并复习文献。结果 SANT 是一种近几年报道的罕见疾病,因其临床表现及影像学检查无特异性,非常容易引起误诊,确诊需依赖其特征性的病理学形态及免疫组织化学染色。结论 SANT 是一种比较罕见的良性病变,预后良好,行脾切除术可以治愈。

  18. Cellular and Axonal Diversity in Molecular Layer Heterotopia of the Rat Cerebellar Vermis

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    Sarah E. Van Dine

    2013-01-01

    Full Text Available Molecular layer heterotopia of the cerebellar primary fissure are a characteristic of many rat strains and are hypothesized to result from defect of granule cells exiting the external granule cell layer during cerebellar development. However, the cellular and axonal constituents of these malformations remain poorly understood. In the present report, we use histochemistry and immunocytochemistry to identify neuronal, glial, and axonal classes in molecular layer heterotopia. In particular, we identify parvalbumin-expressing molecular layer interneurons in heterotopia as well as three glial cell types including Bergmann glia, Olig2-expressing oligodendrocytes, and Iba1-expressing microglia. In addition, we document the presence of myelinated, serotonergic, catecholaminergic, and cholinergic axons in heterotopia indicating possible spinal and brainstem afferent projections to heterotopic cells. These findings are relevant toward understanding the mechanisms of normal and abnormal cerebellar development.

  19. Unilateral periventricular heterotopia and epilepsy in a girl with Ehlers–Danlos syndrome

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    Salvatore Savasta

    2015-01-01

    Conclusion: To our knowledge, this is the first report of unilateral periventricular heterotopia associated with Ehlers–Danlos syndrome. We first hypothesized a mosaicism as the cause of both, a unilateral localization of the heterotopias and a favorable long-term course with good response to anticonvulsant therapy; however, intriguingly, we could not demonstrate a mosaicism as the genetic condition in our patient and the neuroradiological findings and the favorable clinical outcome still remain unexplained.

  20. [Gastric heterotopia of rectum: a rare entity].

    Science.gov (United States)

    Sousa, Jamira; Cabezuelo, Lourdes; Rodrigues, Adriano; Costa, Nascimento; Cipriano, Maria Augusta

    2010-01-01

    Heterotopic gastric mucosa is an extremely rare condition; in the anorectal region only a very few cases were described up to now. The authors report a case of a 46-year-old woman, asymptomatic, to whom a massive recess was discovered in the rectum, at 12 cm of the anal verge; a bottom flat lesion with 1.5 cm of diameter revealed a focus of normal appearing fundic-type gastric mucosa at histology.

  1. A genetic animal model of human neocortical heterotopia associated with seizures.

    Science.gov (United States)

    Lee, K S; Schottler, F; Collins, J L; Lanzino, G; Couture, D; Rao, A; Hiramatsu, K; Goto, Y; Hong, S C; Caner, H; Yamamoto, H; Chen, Z F; Bertram, E; Berr, S; Omary, R; Scrable, H; Jackson, T; Goble, J; Eisenman, L

    1997-08-15

    Malformations of the human neocortex are commonly associated with developmental delays, mental retardation, and epilepsy. This study describes a novel neurologically mutant rat exhibiting a forebrain anomaly resembling the human neuronal migration disorder of double cortex. This mutant displays a telencephalic internal structural heterotopia (tish) that is inherited in an autosomal recessive manner. The bilateral heterotopia is prominent below the frontal and parietal neocortices but is rarely observed in temporal neocortex. Neurons in the heterotopia exhibit neocortical-like morphologies and send typical projections to subcortical sites; however, characteristic lamination and radial orientation are disturbed in the heterotopia. The period of neurogenesis during which cells in the heterotopia are generated is the same as in the normotopic neocortex; however, the cells in the heterotopia exhibit a "rim-to-core" neurogenetic pattern rather than the characteristic "inside-out" pattern observed in normotopic neocortex. Similar to the human syndrome of double cortex, some of the animals with the tish phenotype exhibit spontaneous recurrent electrographic and behavioral seizures. The tish rat is a unique neurological mutant that shares several features with a human cortical malformation associated with epilepsy. On the basis of its regional connectivity, histological composition, and period of neurogenesis, the heterotopic region in the tish rat is neocortical in nature. This neurological mutant represents a novel model system for investigating mechanisms of aberrant neocortical development and is likely to provide insights into the cellular and molecular events contributing to seizure development in dysplastic neocortex.

  2. Diffuse Muscular Pain, Skin Tightening, and Nodular Regenerative Hyperplasia Revealing Paraneoplastic Amyopathic Dermatomyositis due to Testicular Cancer

    OpenAIRE

    Sarah Norrenberg; Valérie Gangji; Véronique Del Marmol; Soyfoo, Muhammad S.

    2012-01-01

    Paraneoplastic dermatomyositis (DM) associated with testicular cancer is extremely rare. We report the case of a patient with skin tightening, polymyalgia, hypereosinophilia, and nodular regenerative hyperplasia revealing seminoma and associated paraneoplastic DM.

  3. Diffuse Muscular Pain, Skin Tightening, and Nodular Regenerative Hyperplasia Revealing Paraneoplastic Amyopathic Dermatomyositis due to Testicular Cancer.

    Science.gov (United States)

    Norrenberg, Sarah; Gangji, Valérie; Del Marmol, Véronique; Soyfoo, Muhammad S

    2012-01-01

    Paraneoplastic dermatomyositis (DM) associated with testicular cancer is extremely rare. We report the case of a patient with skin tightening, polymyalgia, hypereosinophilia, and nodular regenerative hyperplasia revealing seminoma and associated paraneoplastic DM.

  4. Diffuse Muscular Pain, Skin Tightening, and Nodular Regenerative Hyperplasia Revealing Paraneoplastic Amyopathic Dermatomyositis due to Testicular Cancer

    Directory of Open Access Journals (Sweden)

    Sarah Norrenberg

    2012-01-01

    Full Text Available Paraneoplastic dermatomyositis (DM associated with testicular cancer is extremely rare. We report the case of a patient with skin tightening, polymyalgia, hypereosinophilia, and nodular regenerative hyperplasia revealing seminoma and associated paraneoplastic DM.

  5. Study on Clinical Manifestation,EEG and Imaging in Patients with Gray Matter Heterotopia and Epilepsy%脑灰质异位症伴癫痫发作的临床表现及脑电图和影像学特征

    Institute of Scientific and Technical Information of China (English)

    王加强; 冯凯; 王晓飞; 唐俊英

    2011-01-01

    Objective To study the clinical manifestations, EEG and imaging characters in patients with gray matter heterotopia and epilepsy.Methods Clinical data of 14 confirmed patients with GMH and epilepsy from our hospital were analyzed retrospectively, and then the clinical manifestations and imaging features were summarized.Results Of the 14 patients, 9 cases had partial seizures, 6 cases had secondarily generalized seizures, 5 cases had generalized seizures and 3 cases had mental retardation.EEG showed heavy abnormal in 1 cases, medial abnormal in 8 cases and light abnormal in 5 cases.CT/MRI showed Subependymal heterotopia in 4 patients, subcortical heterotopia in 7 patients, band heterotopia in 1 patient and both Subependy-mal and Subcortical heterotopia in 2 patients.Conclusion Partial seizures might be more preponderant in patient with gray matter heterotopia and epilepsy.EEG results are significantly consistent with CT/MRI in judging the presence of local focus in patients with gray matter heterotopia.%目的 研究脑灰质异位症(gray matter heterotopia,GMH)伴癫痫发作的临床表现及脑电图和影像学特征.方法 对我院临床确诊的14例GMH伴癫痫发作患者的临床资料进行回顾性分析,总结该病的临床表现及脑电图和影像学特点.结果 14例患者中部分性发作9例,其中继发全面性发作6例;全面性发作5例.3例智力低下.脑电图结果显示重度异常1例,中度异常8例,轻度异常5例.CT和(或)MRI显示:室管膜下GMH(subependymal GMH,SEH)4例,皮质下GMH(subcortical GMH,SCH)7例,带状GMH(band GMH,BH)1例,混合型GMH 2例.结论 GMH患者的癫痫发作以部分性发作多见.脑电图结果与影像学检查部位相符.

  6. Association of Helicobacter pylori infection with nodular antritis and follicular gastritis

    Directory of Open Access Journals (Sweden)

    Tomašević Ratko

    2006-01-01

    Full Text Available Introduction. Helicobacter pylori (H. pylori infection is known to be the must common cause of chronic gastritis having some endoscopic and pathologic characteristies as determinated by the Sydney System for Gastritis Classification. The aim of our case report was to point out the relationship between an endoscopic finding of nodular antritis and the presence of H. pylori infection and active chronic gastritis. Case report. Our patient underwent upper gastrointestinal endoscopy for dyspeptic complaints and was diagnosed as having nodular antritis, but also underwent urease test and hystopathologic examination of antral mucosa, to determine the presence and density of H. pylori infection and the presence and severity of gastritis. After a course of anti H. pylori treatment, dyspepsia improved and new biopsy specimens obtained two months and six months afterwards revealed no pathological findings. Conclusion. The case report supported the association of H. pylori infection of lymphoid follicles with nodular gastric mucosis.

  7. As duas faces da moeda: heterotopias e emplazamientos curriculares The two faces of the coin: heterotopies and curricular emplazamientos

    Directory of Open Access Journals (Sweden)

    Alfredo Veiga-Neto

    2007-06-01

    Full Text Available A partir dos conceitos foucaultianos de heterotopia e episteme, e do conceito de emplazamiento, proposto por Jorge Larrosa, este artigo discute algumas questões acerca das relações entre o espaço e o currículo. O currículo é aqui compreendido como um artefato que contribuiu para um tipo muito particular de representação do espaço, na episteme clássica. O currículo funcionou para que a espacialidade medieval sensorial, finita e fechada fosse substituída por uma nova espacialidade abstrata, infinita e aberta. Mais tarde, na Modernidade, tal espacialidade extensional deu lugar a uma espacialidade posicional e reticular, a favor da qual o currículo continuou trabalhando. Agora, na Pós-Modernidade, o espaço está assumindo novas configurações. Para descrever uma dessas novas configurações, é muito útil o conceito foucaultiano de heterotopia. As heterotopias são lugares reais, mas elas parecem estar em oposição em relação aos lugares comuns em que vivemos. Desse modo, as heterotopias confundem a linguagem e perturbam nosso entendimento, mas, ao mesmo tempo, abrem a possibilidade de novos pensamentos, novas representações e novos insights acerca do mundo que nos rodeia. Este artigo sugere que é possível conceber o emplazamiento de Larrosa como uma heterotopia. Nesse caso, dá-se a própria profanação da Pedagogia, de modo que novas possibilidades abrem-se para as nossas teorizações e práticas educacionais.From the foucaultian concepts of heterotopy and episteme, and from the concept of emplazamiento developed by Jorge Larrosa, this paper discusses some questions about the relations between the space and the curriculum. Here, the curriculum is assumed as an school artifact implicated with a very particular kind of representation of the space, in the classic episteme. It is argued that the curriculum contributed to the substitution of the medieval spaciality sensorial, finite and closed for a new one abstract, infinite

  8. Nodular cast iron and casting monitoring

    OpenAIRE

    2008-01-01

    In this paper quality monitoring of nodular cast iron and casting made of it is presented. A control system of initial liquid cast iron to spheroidization, after spheroidization and inoculation with using of TDA method was shown. An application of an ultrasonic method to assessment of the graphite form and the metal matrix microstructure of castings was investigated.

  9. Nodular cast iron and casting monitoring

    Directory of Open Access Journals (Sweden)

    S. Pietrowski

    2008-10-01

    Full Text Available In this paper quality monitoring of nodular cast iron and casting made of it is presented. A control system of initial liquid cast iron to spheroidization, after spheroidization and inoculation with using of TDA method was shown. An application of an ultrasonic method to assessment of the graphite form and the metal matrix microstructure of castings was investigated.

  10. Nodular tertiary syphilis in an immunocompetent patient*

    Science.gov (United States)

    Bittencourt, Maraya de Jesus Semblano; de Brito, Arival Cardoso; Nascimento, Bianca Angelina Macêdodo; Carvalho, Alessandra Haber; Drago, Marion Guimarães

    2016-01-01

    Acquired syphilis can be divided into primary, secondary, latent, and tertiary stages. About 25% of patients with untreated primary syphilis will develop late signs that generally occur after three to five years, with involvement of several organs. The authors present an immunocompetent female who developed a tertiary stage syphilis presenting with long-standing nodular plaques. PMID:27579755

  11. Superficially located enlarged lymphoid follicles characterise nodular gastritis.

    Science.gov (United States)

    Okamura, Takuma; Sakai, Yasuhiro; Hoshino, Hitomi; Iwaya, Yugo; Tanaka, Eiji; Kobayashi, Motohiro

    2015-01-01

    Nodular gastritis is a form of chronic Helicobacter pylori gastritis affecting the gastric antrum and characterised endoscopically by the presence of small nodular lesions resembling gooseflesh. It is generally accepted that hyperplasia of lymphoid follicles histologically characterises nodular gastritis; however, quantitative analysis in support of this hypothesis has not been reported. Our goal was to determine whether nodular gastritis is characterised by lymphoid follicle hyperplasia.The number, size, and location of lymphoid follicles in nodular gastritis were determined and those properties compared to samples of atrophic gastritis. The percentages of high endothelial venule (HEV)-like vessels were also evaluated.The number of lymphoid follicles was comparable between nodular and atrophic gastritis; however, follicle size in nodular gastritis was significantly greater than that seen in atrophic gastritis. Moreover, lymphoid follicles in nodular gastritis were positioned more superficially than were those in atrophic gastritis. The percentage of MECA-79 HEV-like vessels was greater in areas with gooseflesh-like lesions in nodular versus atrophic gastritis.Superficially located hyperplastic lymphoid follicles characterise nodular gastritis, and these follicles correspond to gooseflesh-like nodular lesions observed endoscopically. These observations suggest that MECA-79 HEV-like vessels could play at least a partial role in the pathogenesis of nodular gastritis.

  12. A fracture mechanics study of nodular iron; Estudio de una fundicion nodular mediante mecanica de la fractura

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez-Carrasquilla, J. [Universidad Publica de Navarra. Pamplona (Spain); Rios, R. [Centro PolitecnicoSuperior. Zaragoza (Spain)

    1999-07-01

    In the present investigation, nodular graphite cast iron fracture toughness with different matrices and eutectic cell sizes is studied. Properties of tensile strength , hardness and impact toughness are also studied. The experimental data are compared to the same determined parameters in silicon steel with a chemical composition similar to that of the case iron matrix. A subsequent study of the crack surfaces enables us to establish fracture mechanisms. The joint analysis of the mechanical results and of the fractographic studies allows us to establish the influence of graphite on the different mechanical properties of cast iron and on fracture micromechanisms as well. (Author) 7 refs.

  13. VIP and PACAP 38 modulate ibotenate-induced neuronal heterotopias in the newborn hamster neocortex.

    Science.gov (United States)

    Gressens, P; Arquié, C; Hill, J M; Marret, S; Sahir, N; Robberecht, P; Evrard, P

    2000-12-01

    Intracerebral administration of ibotenate produces, through activation of N-methyl-D-aspartate (NMDA) receptors, neuronal heterotopias in the newborn hamster neocortex: high doses of ibotenate induce periventricular and subcortical neuronal heterotopias, while low doses of ibotenate produce intracortical heterotopias and molecular layer ectopias. Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are closely related peptides with neurotrophic properties. They share common VPAC1 and VPAC2 receptors, which use cAMP as a second messenger. Previous studies have shown that VIP prevents excitotoxic neuronal death and exacerbates glutamate-induced c-fos neuronal expression. In order to gain new insight into the molecular control of neuronal migration, the present study examined the effects of VIP and PACAP on ibotenate-induced heterotopias in the newborn hamster. Co-treatment with VIP and a high dose of ibotenate produced a pattern of neuronal heterotopias similar to the one observed in animals treated with low doses of ibotenate alone. Pups co-injected with a low dose of ibotenate and a VIP antagonist displayed cortical dysgeneses similar to those observed in animals treated with high doses of ibotenate alone. The modulating effects of VIP on excitotoxin-induced heterotopias were mimicked by forskolin, PACAP, and by a specific VPAC2 receptor agonist but not by a VPAC1 agonist, and were blocked by a protein kinase A (PKA) inhibitor. Taken together, these data suggest that VIP and PACAP can attenuate ibotenate-induced heterotopias in newborn hamster and that this effect is mediated by the VPAC2 receptor utilizing the cAMP-PKA pathway.

  14. Is endoscopic nodular gastritis associated with premalignant lesions?

    Science.gov (United States)

    Niknam, R; Manafi, A; Maghbool, M; Kouhpayeh, A; Mahmoudi, L

    2015-06-01

    Nodularity on the gastric mucosa is occasionally seen in general practice. There is no consensus about the association of nodular gastritis and histological premalignant lesions. This study is designed to investigate the prevalence of histological premalignant lesions in dyspeptic patients with endoscopic nodular gastritis. Consecutive patients with endoscopic nodular gastritis were compared with an age- and sex-matched control group. Endoscopic nodular gastritis was defined as a miliary nodular appearance of the gastric mucosa on endoscopy. Biopsy samples of stomach tissue were examined for the presence of atrophic gastritis, intestinal metaplasia, and dysplasia. The presence of Helicobacter pylori infection was determined by histology. From 5366 evaluated patients, a total of 273 patients with endoscopic nodular gastritis and 1103 participants as control group were enrolled. H. pylori infection was detected in 87.5% of the patients with endoscopic nodular gastritis, whereas 73.8% of the control group were positive for H. pylori (p gastritis were significantly higher than in the control group. Prevalence of atrophic gastritis and complete intestinal metaplasia were also more frequent in patients with endoscopic nodular gastritis than in the control group. Dysplasia, incomplete intestinal metaplasia and H. pylori infection are significantly more frequent in patients with endoscopic nodular gastritis. Although further studies are needed before a clear conclusion can be reached, we suggest that endoscopic nodular gastritis might serve as a premalignant lesion and could be biopsied in all patients for the possibility of histological premalignancy, in addition to H. pylori infection.

  15. 7例脾硬化性血管瘤样结节性转化的临床病理观察%Sclerosing Angiomatoid Nodular Transformation of the Spleen (SANT):A Clinicopathological Study of Seven Cases

    Institute of Scientific and Technical Information of China (English)

    朱朋成; 晏菲; 杨子萱; 孟莉; 敖启林

    2013-01-01

    目的 探讨脾硬化性血管瘤样结节性转化(SANT)的临床病理特征及相关鉴别诊断.方法 收集7例SANT病例的临床资料和病理切片,选取典型蜡块进行相关标记物的免疫组织化学染色,检测主要指标包括SMA、CD34、CD31、CD4、CD8、CD68、IgG4、IgG等.结果 7例中3例为女性,4例为男性;年龄从28岁到43岁不等,平均年龄37岁;7例中4例为直接诊断为SANT,3例原诊断分别为脾脏错构瘤、脾炎性假瘤和结节性血管瘤,复查后更正为SANT;肿瘤大小从直径4.0 cm到10.5 cm不等,平均直径为6.3 cm;组织学病变呈多结节状,结节周围广泛纤维化和玻璃样变;结节内呈血管瘤样病变,可表现为毛细血管瘤样构象或窦岸血管瘤样构象.免疫组织化学示结节内血管CD31恒定阳性,但CD34和CD8表达有所差异.结论 SANT是一种罕见的脾脏原发的良性瘤样病变,具有特征性的组织学和免疫组织化学表现,应和脾脏原发的其他良恶性肿瘤进行鉴别.%Objective To investigate the clinicopathological features and differential diagnosis of sclerosing angiomatoid nodular transformation (SANT) of the spleen. Methods Clinical data of 7 cases of SANT were retrospectively analyzed. Typical paraffin-embedded blocks were obtained and used for the immunohistochemical staining of CD34 , CD31, SMA, CD68,CD4 ,CD8,IgG and IgG4. Results The study involved 3 females and 4 males with their age ranging from 28 to 4 3 years (mean:37 years). Among the patients,4 were initially diagnosed with SANT,and 3 cases were mistaken for hamartoma,heman-gioma or inflammatory pseudotumor of the spleen on their first diagnosis. The tumor size ranged from 4. 0 cm to 10. 5 cm (mean:6. 3 cm). The typical histologic features were multiple well-circumscribed angiomatoid nodules showing plump endotheli-al cells and extravasated erythrocytes. The nodules were surrounded by a variable lymphoplasmacytic infiltrate,spindle cells,and collagenous stroma

  16. Nodular cystic fat necrosis with calcification in a patient with juvenile dermatomyositis.

    Science.gov (United States)

    Ferenczi, Katalin; Berke, Adrienne; Makkar, Hanspaul S

    2014-01-01

    Nodular cystic fat necrosis is a rare, benign form of encapsulated fat necrosis with distinct histology, characterized by cystic fat necrosis with lipomembranous changes and, in later stages, calcification. We report the case of a 7-year-old child with juvenile dermatomyositis who presented with three asymptomatic, firm, mobile nodules on the arms and neck. Histology was consistent with nodular cystic fat necrosis with prominent calcification. This is an unusual presentation of this entity because it has never been previously reported in association with juvenile dermatomyositis.

  17. Intra-articular nodular fasciitis of the knee: a rare cause of recurrent hemarthrosis.

    Science.gov (United States)

    Matsuzaki, Tokio; Akisue, Toshihiro; Kishimoto, Kenta; Kishimoto, Shin-ichiro; Imabori, Masaya; Hara, Hitomi; Okada, Yoshiyuki; Hitora, Toshiaki; Kuroda, Ryosuke; Kurosaka, Masahiro; Yamamoto, Tetsuji

    2012-06-01

    A 20-year-old man presented with pain and recurrent hemarthrosis in the right knee. Magnetic resonance imaging of the knee showed a lesion with homogeneous low signal intensity on T1-weighted images and a heterogeneous, low to high signal intensity on T2-weighted images. At arthroscopy, the mass was located between the posterior cruciate ligament and the posterior knee joint capsule. The tumor was excised through a posterior approach and histologically diagnosed as a nodular fasciitis. Intra-articular nodular fasciitis is a very rare clinicopathologic entity. The current case showed the unique clinical feature of recurrent hemarthrosis at initial presentation, which has not been previously reported.

  18. 脾硬化性血管瘤样结节性转化2例临床病理特征%Sclerosing angiomatoid nodular transformation of spleen: a clinicopathologic analysis of two cases

    Institute of Scientific and Technical Information of China (English)

    成志强; 王晓玫; 俞丽娜; 胡锦涛; 高利昆; 彭全州; 陈灼怀; 张石芬

    2012-01-01

    目的 探讨脾硬化性血管瘤样结节性转化(SANT)的临床病理特征、诊断与鉴别诊断要点及治疗方法.方法 对2例SANT的临床病理特征及免疫组化表达进行详细的观察并复习相关文献.结果 2例SANT的临床表现无特异性.组织学镜下见具有众多由环靶状纤维组织围绕的肉芽肿样结节,伴有结节间不同程度硬化的间质;肉芽肿样结节内细胞呈卵圆形、短梭形,胞质相对丰富,部分细胞胞质内可形成含红细胞的腔隙,细胞间还穿插有衬覆肥胖内皮细胞的枝芽状毛细血管及相对扩张的窦隙样血管腔隙.免疫组化示结节内不同血管样结构有3种不同的表达,结节内梭形、卵圆形细胞CD31、CD68和SMA呈不同程度(+),而CD21、S-100和EMA均(-).术后随访,患者未发现病变复发和转移.结论 SANT是脾具有特征性改变的一种良性病变,过去易与脾炎性假瘤、错构瘤或血管瘤等相混淆.行脾切除术可治愈,预后良好.%Objective To investigate the clinicopathologic features, diagnosis, differential diagnosis and treatment of sclerosing angiomatoid nodular transformation ( SANT). Methods The clinical and pathological features with immunostaining were described in detail in 2 cases of SANT, and related literatures were reviewed. Results There were no specific findings in the clinical manifestations in the 2 cases of SANT. The morphological features of SANTs were as follows; multiple nodules in granuloma-like appearance were surrounded by a prominent shell of concentrically deposited fibers, and in variably fibrosclerotic stroma. There were spindly or ovoid cells in the nodules which had plenty of cytoplasm and indistinct cell borders. Some of them had vascular spaces in cytoplasm and could hold red cells in it. Furthermore, there were variable shapes of vascular spaces lined by plump endothelial cells interspersed in nodules. Immunostaining revealed there were 3 distinct types of vessels in

  19. Nodular lymphocyte-predominant Hodgkin lymphoma.

    Science.gov (United States)

    Savage, Kerry J; Mottok, Anja; Fanale, Michelle

    2016-07-01

    Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare subtype of Hodgkin lymphoma with distinct clinicopathologic features. It is typified by the presence of lymphocyte predominant (LP) cells, which are CD20(+) but CD15(-) and CD30(-) and are found scattered amongst small B lymphocytes arranged in a nodular pattern. Despite frequent and often late or multiple relapses, the prognosis of NLPHL is very favorable. There is an inherent risk of secondary aggressive non-Hodgkin lymphoma (NHL) and studies support that risk is highest in those with splenic involvement at presentation. Given disease rarity, the optimal management is unclear and opinions differ as to whether treatment paradigms should be similar to or differ from those for classical Hodgkin lymphoma (CHL). This review provides an overview of the existing literature describing pathological subtypes, outcome and treatment approaches for NLPHL.

  20. Nodular Fasciitis of the Chest Wall as seen on Breast Sonography: This Clinically Simulated Palpable Breast Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Woo Jeong; Lee, Jin Hwa; Kang, Eun Ju; Kim, Dae Cheol; Cho, Se Heon; Nam, Kyung Jin [Dong-A University College of Medicine, Busan (Korea, Republic of)

    2011-09-15

    Nodular fasciitis is a rapidly growing benign soft tissue tumor that is related to the fascia and this tumor is generally seen in young and middle aged adults. It is often seen as a subcutaneous solitary nodule in an upper extremity. Clinically, it is often mistaken for a malignancy. We present here a rare case of nodular fasciitis of the chest wall and that was observed on breast sonography (US) and this lesion clinically simulated palpable breast cancer. US may be helpful for evaluating a chest wall lesion that is misunderstood to be a breast lump. So, if the lesion's location is vague, US can reveal the exact location and characteristics of the mass. Although the incidence of nodular fasciitis is rare, nodular fasciitis should be considered in the differential diagnosis when a lesion is located in the chest wall

  1. 脾脏硬化性血管瘤样结节性转化诊治(附1例报道及相关文献复习)%Diagnoses and therapy of sclerosing angiomatoid nodular transformation in the spleen report of I case and correlative iterature review

    Institute of Scientific and Technical Information of China (English)

    刘旭; 王兰

    2012-01-01

    目的 探讨脾脏硬化性血管瘤样结节性转化(sclerosing angiomatoid nodular transformation,SANT)的诊断及治疗,提高对SANT的认识,避免误诊.方法 报道1例SANT的诊治过程并复习相关文献.结果 SANT是一种近年报道的罕见疾病,因临床表现及影像学检查无特异性,极易误诊,确诊需依赖其特征性的病理学形态及免疫组织化学染色.结论 SANT是一种罕见的良性病变,预后良好,行脾切除术可治愈.%Objective To explore the diagnoses and therapy of sclerosing angiomatoid nodular transformation to help us to deepen the understanding of it. Methods One case of SANT are reported and correlative other 30 cases of correlative literature are reviewed. Results SANT is a rare disease which is reported recent years. Because of lacking characteristic clinical course and ra-diologic features, it is often misdiagnosed, histological appearance and immunohistochemical staining are essential to clarify the diagnosis. Contusion SANT is a benign change in the spleen,which has a favourable prognosis and can be cured by splenectomy.

  2. Multifocal nodular periostitis associated with prolonged voriconazole therapy in a lung transplant recipient.

    Science.gov (United States)

    Ayub, Asad; Kenney, Charles V; McKiernan, Fergus E

    2011-03-01

    We report a case of painful, nodular periostitis in a lung transplant recipient on long-term voriconazole therapy. Symptoms, signs, and laboratory abnormalities resolved quickly after drug withdrawal. The presentation more closely resembles periostitis deformans than hypertrophic osteoarthropathy, suggesting that the fluoride moiety of voriconazole may be pathogenic for this condition. Clinicians should be aware of this association.

  3. CYTOGENETIC STUDY OF A NODULAR HYPERPLASIA OF THE THYROID AFTER IRRADIATION FOR HODGKINS-DISEASE

    NARCIS (Netherlands)

    VANDENBERG, E; VANDOORMAAL, JJ; OOSTERHUIS, JW; DEJONG, B; BUIST, J; VOS, AM; VERMEIJ, A; Dam, A.

    We describe cytogenetics of a case of nodular hyperplasia of the thyroid with papillary microcarcinoma following radiotherapy for Hodgkin's disease. The chromosomal pattern found was very heterogeneous with a clonal abnormality of chromosome 10, among others. Together with some recent data from the

  4. CYTOGENETIC STUDY OF A NODULAR HYPERPLASIA OF THE THYROID AFTER IRRADIATION FOR HODGKINS-DISEASE

    NARCIS (Netherlands)

    VANDENBERG, E; VANDOORMAAL, JJ; OOSTERHUIS, JW; DEJONG, B; BUIST, J; VOS, AM; VERMEIJ, A; Dam, A.

    1991-01-01

    We describe cytogenetics of a case of nodular hyperplasia of the thyroid with papillary microcarcinoma following radiotherapy for Hodgkin's disease. The chromosomal pattern found was very heterogeneous with a clonal abnormality of chromosome 10, among others. Together with some recent data from the

  5. Disease: H00270 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00270 Periventricular nodular heterotopia (PVNH) Periventricular nodular heterotopia...Exp Brain Res 173:322-33 (2006) PMID:15996530 Lu J, Sheen V Periventricular heterotopia. Epilepsy Behav 7:143-9 (2005) ...

  6. Habitus, Heterotopia and Endocolonialism in Early Spanish Literary Fascism

    Directory of Open Access Journals (Sweden)

    Nil Santiáñez

    2009-06-01

    Full Text Available This article explores strategies of symbolic production of national space (e.g. technologies of tropological striation in early fascist works of Tomás Borrás, Luys Santa Marina, and Rafael Sánchez Mazas written à propos the Rif War (1919-27. Considered as perlocutionary speech-acts, these texts conceive Morocco as a heterotopia and embody a fascist habitus produced by a heterogeneous group of writers, intellectuals, politicians and military personnel—in particular the notorious Foreign Legion—posted in Morocco; they all shared the defense of an authoritarian concept of nation as a model for the political organization of Spain as well as an endocolonialist gaze and stance towards their own country. By means of its tropological conquest of Moroccan territory, Fascist writing devoted to the Rif War duplicated the empirical spatial production carried out in situ by the army and the civilian administration of the Spanish protectorate of Morocco. Making it intelligible as well as modifying it, such writing brought to the Peninsula an endocolonial project and an incipient fascist habitus. Its development in the 1930s (the theory of fascism, Falange Española, the Falangists’ direct action in the streets of Spain, the tactics and strategy followed by the High Command of Franco’s army during the civil war would culminate after 1939 in the empiric production of a new administrative, political and economic organization of Spain’s national territory.

  7. Peptic ulcer in the gallbladder. A case report

    DEFF Research Database (Denmark)

    Larsen, E H; Diederich, P J; Sørensen, Flemming Brandt

    1985-01-01

    Gastric mucosa can be found in the gallbladder as a congenital heterotopia. A case of a perforated peptic ulcer in the gallbladder with concomitant hemorrhage in heterotopic gastric mucosa causing hematemesis and melena is presented.......Gastric mucosa can be found in the gallbladder as a congenital heterotopia. A case of a perforated peptic ulcer in the gallbladder with concomitant hemorrhage in heterotopic gastric mucosa causing hematemesis and melena is presented....

  8. Peptic ulcer in the gallbladder. A case report

    DEFF Research Database (Denmark)

    Larsen, E H; Diederich, P J; Sørensen, Flemming Brandt

    1985-01-01

    Gastric mucosa can be found in the gallbladder as a congenital heterotopia. A case of a perforated peptic ulcer in the gallbladder with concomitant hemorrhage in heterotopic gastric mucosa causing hematemesis and melena is presented.......Gastric mucosa can be found in the gallbladder as a congenital heterotopia. A case of a perforated peptic ulcer in the gallbladder with concomitant hemorrhage in heterotopic gastric mucosa causing hematemesis and melena is presented....

  9. Cushing syndrome in a young woman due to primary pigmented nodular adrenal disease.

    Science.gov (United States)

    Hackman, Kathryn L; Davis, Anna L; Curnow, Paul A; Serpell, Jonathan W; McLean, Catriona A; Topliss, Duncan J

    2010-01-01

    To report a case of Cushing syndrome due to apparently sporadic primary pigmented nodular adrenal disease in a young woman. We describe the clinical, biochemical, radiologic, and histologic findings of Cushing syndrome due to the rare condition of primary pigmented nodular adrenal disease. A 30-year-old woman presented with a 2-year history of worsening itch without rash over her shoulders and arms and weight gain, particularly around the abdomen and face. Careful questioning did not elicit any history of exogenous glucocorticoid use (systemic or topical), including hydrocortisone. On examination, the patient had a slightly rounded and plethoric face, a small buffalo hump, central adiposity, and thin skin with a few small striae on her inner thighs. No features of the Carney complex were observed. Investigations showed hypercortisolism with suppressed corticotropin and normal adrenal imaging despite documentation of enlarged adrenal glands at removal. High-dose dexamethasone administration was followed by a decrease in urinary free cortisol excretion rather than a paradoxical rise as previously reported in primary pigmented nodular adrenal disease. No mutations were detected in the PRKAR1A gene. Primary pigmented nodular adrenal disease should be suspected in patients with corticotropin-independent Cushing syndrome who have normal adrenal imaging. The role of genetic testing in apparently sporadic cases is not established, but cumulative experience may be helpful in defining the frequency of PRKAR1A mutations.

  10. Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma.

    Science.gov (United States)

    Joseph, Nancy M; Ferrell, Linda D; Jain, Dhanpat; Torbenson, Michael S; Wu, Tsung-Teh; Yeh, Matthew M; Kakar, Sanjay

    2014-01-01

    Inflammatory hepatocellular adenoma can show overlapping histological features with focal nodular hyperplasia, including inflammation, fibrous stroma, and ductular reaction. Expression of serum amyloid-associated protein in inflammatory hepatocellular adenoma and map-like pattern of glutamine synthetase in focal nodular hyperplasia can be helpful in this distinction, but the pitfalls and limitations of these markers have not been established. Morphology and immunohistochemistry were analyzed in 54 inflammatory hepatocellular adenomas, 40 focal nodular hyperplasia, and 3 indeterminate lesions. Morphological analysis demonstrated that nodularity, fibrous stroma, dystrophic blood vessels, and ductular reaction were more common in focal nodular hyperplasia, while telangiectasia, hemorrhage, and steatosis were more common in inflammatory hepatocellular adenoma, but there was frequent overlap of morphological features. The majority of inflammatory hepatocellular adenomas demonstrated perivascular and/or patchy glutamine synthetase staining (73.6%), while the remaining cases had diffuse (7.5%), negative (3.8%), or patchy pattern of staining (15%) that showed subtle differences from the classic map-like staining pattern and was designated as pseudo map-like staining. Positive staining for serum amyloid-associated protein was seen in the majority of inflammatory hepatocellular adenomas (92.6%) and in the minority of focal nodular hyperplasia (17.5%). The glutamine synthetase staining pattern was map-like in 90% of focal nodular hyperplasia cases, with the remaining 10% of cases showing pseudo map-like staining. Three cases were labeled as indeterminate and showed focal nodular hyperplasia-like morphology but lacked map-like glutamine synthetase staining pattern; these cases demonstrated a patchy pseudo map-like glutamine synthetase pattern along with the expression of serum amyloid-associated protein. Our results highlight the diagnostic errors that can be caused by variant

  11. Nodular Lymphocyte Predominant Hodgkin Lymphoma of the Thyroid

    Science.gov (United States)

    Cassis, João; Simões, Helder; Sequeira Duarte, João

    2016-01-01

    Thyroid lymphomas are rare clinical entities that may result from either the primary intrathyroid de novo or secondary thyroid gland involvement of a lymphoma. Among these, the Hodgkin's subtype is quite uncommon, accounting for 0.6–5% of all thyroid malignancies. The authors report on a 76-year-old female presenting with a thyroid nodule that, upon surgical excision, was found to be a nodular lymphocyte predominant Hodgkin lymphoma of the thyroid. So far, thyroid involvement by this variant has never been reported. Upon reporting on this clinical case, the authors emphasize the difficulties usually found in establishing the diagnosis and in defining the best management strategy. A thorough review of the available literature is done. PMID:28044111

  12. Visions and heterotopias: the Iconografy of the ruins in the definitio of contemporary urban landscapes

    Directory of Open Access Journals (Sweden)

    Gregorio Froio

    2014-05-01

    Full Text Available The purpose of this essay is to describe the thin red line that connects the multiple meanings of the term archeology with the visual representation of the contemporary city. The iconography of urban views especially from a reading decentralized and alienating: the archaelogical character of the post-metropolis becomes the kay scenes in the balance between urban utopias and heterotopias.

  13. What Is It Like to Be a Child? Childhood Subjectivity and Teacher Memories as Heterotopia

    Science.gov (United States)

    Chang-Kredl, Sandra; Wilkie, Gala

    2016-01-01

    Foucault's notion of heterotopia offers a novel way to understand teachers' conceptualizations of childhood, in juxtaposing adult memories of childhood with their present context of teaching children. Memory writing prompts were given to 41 early childhood teachers, and the resulting written narratives were analyzed as heterotopic spaces. The…

  14. Latinas, Heterotopia, and Home: Pedagogies of Gender and Sexuality in Quinceañera

    Science.gov (United States)

    Bondy, Jennifer M.

    2012-01-01

    In this article the author discusses Foucault's heterotopia analytic and applies it to a film analysis of Quinceañera. Engaging in feminist and critical media scholarship, the author outlines U.S. discourses on girlhood and their collusion with patriarchal and heteronormative discourses on Latino cultural nationalism in the regulation, control,…

  15. Linking social capital, cultural capital and heterotopia at the folk festival

    Directory of Open Access Journals (Sweden)

    Linda Wilks

    2016-06-01

    Full Text Available This paper investigates the role of folk festivals in transforming interconnections between people, space and culture. It interlinks three sets of theoretical ideas: social capital, cultural capital and heterotopia to suggest a new conceptual framework that will help to frame a deeper understanding of the nature of celebration. Qualitative data were collected at two long-established folk festivals, Sidmouth Folk Festival in southern England and the Feakle Traditional Music Festival in western Ireland, in order to investigate these potential links. Although Foucault did not fully develop the concept of heterotopia, his explanation that heterotopias are counter-sites, which, unlike utopias, are located in real, physical, space-time, has inspired others, including some festival researchers, to build on his ideas. This study concludes that the heterotopian concept of the festival as sacred space, with the stage as umbilicus, may be linked to the building of social capital; while it is suggested that both social capital and appropriate cultural capital are needed to gain full entry to the heterotopia.

  16. Syncytial Variant of Nodular Sclerosis Classical Hodgkin Lymphoma of the Terminal Ileum in a Patient with Longstanding Crohn's Disease.

    Science.gov (United States)

    Gibson, Bradley; Podoll, Mirna Bajramovic; Baumgartner, Erin Marie; Maley, Diana Haninger

    2016-01-01

    Primary Hodgkin lymphoma of the gastrointestinal tract is an uncommon malignancy with few reported cases. Here we describe a rare variant of Hodgkin lymphoma presented in the gastrointestinal tract in association with Crohn's Disease.The patient is a 58 year old male with a 40 year history of formerly well-controlled Crohn's disease who presented with abdominal discomfort and constitutional symptoms. Computed tomography showed a 10 cm thickened segment of ileum and a dilated segment of small bowel. The patient underwent segmental resection, revealing a mass, which was diagnosed by pathology as nodular sclerosis classical Hodgkin lymphoma, syncytial variant.There are only 29 reported cases of syncytial variant of nodular sclerosis classical Hodgkin lymphoma. This is the second documented case of primary gastrointestinal syncytial variant of nodular sclerosis classical Hodgkin lymphoma. Further characterization of this entity is necessary.

  17. Advances in gray matter heterotopia in children%儿童灰质异位症的研究进展

    Institute of Scientific and Technical Information of China (English)

    沈雁文

    2013-01-01

    Gray matter heterotopias,which can be classified into subependymal heterotopia,subcortical heterotopia,band heterotopia and mixed heterotopia,belongs to neuronal migration disorders.Any factors including physical or chemical factors,biological factors and genetical factors that occur during neuronal migration phase can lead to gray matter heterotopias.The latest studies have revealed many genes are involved in the pathogenesis of gray matter heterotopias,especially in subependymal heterotopia and band heterotopia with their own characteristics.The main clinical disorders in pediatric heterotopias include developmental delay,epilepsy and motor disturbance.The diagnosis of the disease is made through neuroimaging examinations especially magnetic resonance imagings.The advanced magnetic techniques like magnetic resonance spectroscopy and functional magnetic resonance can be helpful in the final diagnosis.%灰质异位症为神经元移行障碍的一种,可分为室管膜下型、皮层下型、板层型及混合型四种临床类型;发生于神经元移行期的各种理化及生物因素、遗传因素均可导致该症的产生.最新研究表明,基因异常在灰质异位症,尤其是室管膜下型灰质异位症及板层型灰质异位症的发生中,占有重要作用,且其表现有一定特异性.灰质异位症儿童期发病主要表现为发育落后、癫(痫)及运动障碍,其诊断主要依靠影像学检查,尤其是磁共振检查.磁共振新技术,如磁共振波谱分析、功能磁共振等可协助诊断该病.

  18. Wear resistance of nodular cast iron with carbides

    Directory of Open Access Journals (Sweden)

    G. Gumienny

    2011-07-01

    Full Text Available In this paper results of abrasive and adhesive wear resistance of selected grades of nodular cast iron with carbides are presented. It was demonstrated, that the maximum wear resistance has got nodular cast iron with the microstructure of upper bainite, lower bainite and carbides. This cast iron with hardened steel and sulfonitrided steel is the most advantageous friction pair during adhesive wear testing. It was found, that the least advantageous friction pair is pearlitic nodular cast iron with carbides and normalized steel.

  19. Primary leiomyosarcoma of the abdominal wall mimicking nodular fasciitis in a child

    Directory of Open Access Journals (Sweden)

    Yuhki Koike

    2015-06-01

    Full Text Available We report the case of an 8-year-old boy with a 30-mm solid mass in the right lower quadrant of the abdominal wall. Computed tomography revealed that the tumor was on the lateral border of the rectus abdominis, and surgical resection was performed. Despite difficulty in differentiating this mass from nodular fasciitis, pathologic analysis and immunohistochemical staining led to the diagnosis of leiomyosarcoma.

  20. Primary leiomyosarcoma of the abdominal wall mimicking nodular fasciitis in a child

    OpenAIRE

    Koike, Yuhki; Imaoka, Hiroki; Otake, Kohei; Inoue, Mikihiro; Uchida, Keiichi; Kusunoki, Masato

    2015-01-01

    We report the case of an 8-year-old boy with a 30-mm solid mass in the right lower quadrant of the abdominal wall. Computed tomography revealed that the tumor was on the lateral border of the rectus abdominis, and surgical resection was performed. Despite difficulty in differentiating this mass from nodular fasciitis, pathologic analysis and immunohistochemical staining led to the diagnosis of leiomyosarcoma.

  1. 脾脏硬化性血管瘤样结节性转化5例临床病理分析%Sclerosing angiomatoid nodular transformation (SANT) of the spleen: a report of 5 cases

    Institute of Scientific and Technical Information of China (English)

    李倩玉; 朱延波; 奚豪; 桂贤; 张莉萍; 蒋虹伟

    2011-01-01

    目的 探讨脾脏硬化性血管瘤样结节性转化(sclerosing angiomatoid nodular transformation,SANT)的临床病理表现、诊断及鉴别诊断要点.方法 对5例SANT的临床、组织病理学形态及免疫组化特征进行形态学观察并文献复习.结果 5例中只有1例有临床症状.眼观脾脏SANT多为孤立性病灶,与周围脾组织界清,中心为白色瘢痕样外观.镜下呈多结节表现,结节中心为多个裂隙样或不规则型富含红细胞的血管腔隙,内衬肥胖的上皮细胞.结节周围靶环状紧密排列梭型、卵圆形细胞,间质内有淋巴细胞、浆细胞及组织细胞浸润.免疫组化显示血管样腔隙呈现3种不同的免疫表型:CD34-/CD31+/CD8+、CD34+/CD31+/CD8-和CD34-/CD31+/CD8-.结节周围梭型、卵圆形细胞呈现不同程度的SMA、CD31、CD68均(+).结论 SANT是源自脾脏红髓的具有独特形态学特点的血管瘤样病变,易与炎性假瘤、血管瘤等相混淆,临床呈良性表现.

  2. 急性痘疮样糠疹合并结节性血管炎1例%A Case Report of Pityriasis Lichenoides Etvarioliformis Acuta And Nodular Vasculitis

    Institute of Scientific and Technical Information of China (English)

    雷微; 陈永艳; 袁伟; 黄洋

    2011-01-01

    患者女,26岁.全身丘疹3月,四肢结节伴疼痛10天.皮损为圆形丘疹,表面有鳞屑覆盖,周围绕以红晕,以四肢明显,部分丘疹中心萎缩凹陷;左前臂、双小腿伸侧散在红色皮下结节,有压痛感.组织病理示:①小腿丘疹:表皮内见基底细胞灶性液化变性,真皮浅层血管周围大量淋巴细胞、组织细胞浸润,可见血管外红细胞.②小腿结节:皮下脂肪组织内见一大血管破坏,周围脂肪小叶弥漫性炎细胞浸润.诊断:急性痘疮样糠疹合并结节性血管炎.%A26-year-old female presented with body pimples for three months, limbs nodules with tendemess for ten days. Lcsions are round papules to clear limbs, and which surface with scales, and around to flush, some papules center atrophy depression; the red subcutaneous nodule on the left forearm and shank with tenderness. After histopathological examination, the pathologic slice of the papules on her shank shows focal liquefaction degeneration of basal cell in the epidermis, a large number of lymphocytes and histocytes around the superficial dermal vessels. and some crythrocytes out of the vessel. The nodules of her shank pathologica slice shows the angiolysis in the subcutancous adipose tissue and the surrounding fat lobules with diffuse infiltration of inflammatory cells. Diagnosis: Pityriasis lichcnoides etvarioliformis acuta and nodular vaseulitis.

  3. Clinical application of cerebral grey matter imaging at 3.0T MR for gray matter heterotopia%3.0T MR脑灰质成像在脑灰质异位中的应用

    Institute of Scientific and Technical Information of China (English)

    袁飞; 刘银社; 赵军; 袁滨; 张忠强; 艾克文

    2011-01-01

    目的 探讨3.0T MR脑灰质成像在脑灰质异位症中的诊断价值.方法 回顾性分析25例经临床及MRI检查确诊的脑灰质异位症病人的MRI资料,全部病人均行头颅MRI常规T1WI、T2WI序列,FLAIR序列和脑灰质成像检查.结果 25例中,病变为双侧14例,单侧11例,多病灶17例.室管膜下型13例,皮层下局灶型10例,其中2例病人室管膜下及皮层下局灶并存,皮层下弥漫型2例.1例病人并发多微小脑回畸形,1例病人同时伴有透明隔缺如.在病变显示方面,灰质成像明显优于T1WI、T2WI及FLAIR(χ2=21.16,P <0.05).结论 3.0T MR脑灰质成像对显示灰质异位病变的部位和范围具有重要价值.%Objective To study the clinical value of MR grey matter imaging in diagnosing cerebral gray matter heterotopia. Methods 25 cases of gray matter heterotopia confirmed by clinic were retrospectively analyzed. All cases underwent MR examination with routine T1 WI,T2 WI,FLAIR sequences and grey matter imaging. Results The lesions were bilateral in 14 cases and unilateral in 11 cases and multi-heterotopia of gray matter in the periventricular and subcortical white matter in 17 cases. 13 cases were subependymal type,l0 cases were subcortical type (locally) including 2 cases with both subependymal and subcortical type,2 were diffusion subcortical type. The lesions associated with polymicrogyri and absence of septum pellucidum in one case, respectively. cerebral grey matter imaging was obviously superior to T1 WI, T2 WI and FLAIR ( X2 = 21. 16 , P<O. 05 ) in displaying the morphology and extent of the lesions. Conclusion 3. OT MR grey matter imaging is of significant value in showing the location and extent of gray matter heterotopia.

  4. Surgical treatment of epilepsy induced by gray matter heterotopia%灰质异位所致癫痫的外科治疗

    Institute of Scientific and Technical Information of China (English)

    罗智刚; 唐运林; 周连银; 周辉; 卞园园; 单健; 张奕生

    2009-01-01

    Objective To explore the relationship between gray matter heterotopia and epilepsy and assess the therapeutic effect of surgical intervention. Methods Six cases of gray matter heterotopia-induced epilepsy treated in our department between May, 2004 and May, 2006 were analyzed retrospectively for the clinical characteristics, surgical approaches, and the outcomes in the 2- to 4-year-long follow-up. Results All the patients received surgical interventions through different approaches, including resection of the heterotopic gray matter plus bipolar coagulation of the cortexes in 4 cases, heterotopic gray matter resection with bipolar coagulation of the cortexes and temporal lobectomy in 1 case, and exclusive bipolar coagulation of the cortexes in 1 case. Five patients were free of seizure attach and 1 patient showed significantly reduced seizure attack after the operation. Conclusion Surgical intervention can be effective for treatment of intractable epilepsy induced by gray matter heterotopia.%目的 探讨大脑灰质异位(HGM)与癫痫的关系,以及手术治疗的价值. 方法 回顾性分析解放军第四五八医院神经外科自2004年5月至2006年5月收治的6例HGM所致癫痫患者的临床特点、手术方式以及随访结果. 结果 6例患者中,4例行异位灰顶切除+皮层热灼,1例行异位灰顶切除+皮层热灼+前颞叶切除.1例行单纯皮层热灼.术后随访2~4年,5例至今未见发作,1例发作明显缓解. 结论 对于HGM所致的难治性癫痫,外科手术是一个有效的治疗方法.

  5. Nodular thyroid disease and thyroid malignancy: Experience at ...

    African Journals Online (AJOL)

    Nodular thyroid disease and thyroid malignancy: Experience at Polokwane Mankweng ... had malignant lesions (7 follicular carcinomas and 3 papillary carcinomas), ... The prevalence of thyroid cancer in our study was 11.1%, and of all 90 ...

  6. The Erotic Conception of Ancient Greek Landscapes and the Heterotopia of the Symposium

    OpenAIRE

    Heirman, Jo

    2012-01-01

    In his article "The Erotic Conception of Ancient Greek Landscapes and the Heterotopia of the Symposium" Jo Heirman discusses the conception of natural landscapes in ancient Greek lyric poetry from the seventh until the fifth century BC and its ideological background. Heirman analyzes lyric poems by Sappho, Ibycus, and Theognis in which landscapes of fields, gardens, and meadows are presented. Heirman's analysis reveals a recurrent erotic pattern in the conception of ancient Greek landscapes c...

  7. Disturbances in the positioning, proliferation, and apoptosis of neural progenitors contribute to subcortical band heterotopia formation

    OpenAIRE

    2010-01-01

    Cortical malformations are commonly associated with intractable epilepsy and other developmental disorders. Our studies utilize the tish rat, a spontaneously occurring genetic model of subcortical band heterotopia (SBH) associated with epilepsy, to evaluate the developmental events underlying SBH formation in the neocortex. Our results demonstrate that Pax6+ and Tbr2+ progenitors are mislocalized in tish+/− and tish−/− neocortex throughout neurogenesis. In addition, mislocalized tish−/− proge...

  8. Learning through Nomadic Interiors - Villa Rotonda through the lenses of Heterotopia

    DEFF Research Database (Denmark)

    Hvejsel, Marie Frier; Fisker, Anna Marie

    2015-01-01

    in a series of nomadic interiors allowing the students to travel in time and place; from Palladio to the 14th Architectural Biennale and from Vincenza to Venice. In the paper we use Foucaults concept of Heterotopia to analyze how a window in 1:10 from the south façade of Villa Rotonda now re......-designed in caramelized sugar can create a parallel learning space; an interior that make a utopian space possible....

  9. Activating GNAS and KRAS mutations in gastric foveolar metaplasia, gastric heterotopia, and adenocarcinoma of the duodenum

    OpenAIRE

    Matsubara, A.; Ogawa, R; Suzuki, H; Oda, I.; Taniguchi, H; Kanai, Y.; Kushima, R; Sekine, S

    2015-01-01

    Background: Heterotopic gastric-type epithelium, including gastric foveolar metaplasia (GFM) and gastric heterotopia (GH), is a common finding in duodenal biopsy specimens; however, there is still controversy regarding their histogenetic backgrounds. Methods: We analysed a total of 177 duodenal lesions, including 66 GFM lesions, 81 GH lesions, and 30 adenocarcinomas, for the presence of GNAS, KRAS, and BRAF mutations. Results: Activating GNAS mutations were identified in 27 GFM lesions (41%) ...

  10. 带状型灰质异位合并分离型脑裂畸形和透明隔部分缺如的临床和影像学特点(附1例报告)%Clinical and imaging features of subcortical band heterotopia complicated with open-lip schizencephaly and septum pellucidum partial deletion (report of 1 case)

    Institute of Scientific and Technical Information of China (English)

    杨中原; 任传成

    2013-01-01

    目的 探讨带状型灰质异位(SBH)合并分离型脑裂畸形(OS)和透明隔部分缺如(SPPD)的临床和影像学特点.方法 回顾性分析1例SBH合并OS和SPPD患者的临床资料.结果 本例患者幼年起病,以右侧肢体发育短小、右侧肢体痉挛性高肌张力、右侧肢体运动功能障碍,以及青年期发病的癫痫发作、发作性意识障碍为主要症状.头颅CT平扫示左侧顶叶脑裂畸形伴灰质异位.头颅MRI平扫示左侧顶叶脑裂畸形,与左侧脑室相通,裂隙周边为连续迂曲状T1WI低信号、T2WI高信号影(与灰质信号一致),左侧脑室扩大,部分透明隔缺如.结论 SBH合并OS和SPPD患者常见表现为癫痫、精神智能发育迟滞和神经系统功能缺失等,其影像学特点为侧脑室旁与灰质之间的白质中出现边界清晰、规则的灰质,呈“双皮质”样;同时可见OS和SPPD.%Objective To explore the clinical and imaging features of subcortical band heterotopia ( SBH) complicated with open-lip schizencephaly ( OS) and septum pellucidum partial deletion ( SPPD). Methods The clinical data of one SBH patient complicated with OS and SPPD was analyzed retrospectively. Results The patient with juvenile onset, the right limb development in short, the spastic muscle tone of the right side, the motor dysfunction of the right side, and adolescent onset seizures, episodic disturbance of consciousness as the main symptoms. Cranial CT scan showed that left parietal schizencephaly with gray matter heterotopia. Cranial MRI scan showed that left parietal schizencephaly connected with the left ventricle; the schizencephaly was surrounded by a continuous tortuous-like low signal in T1WI and high signal in T2WI intensity (consistent with gray matter signal) ; the left ventricle expanded; part of the septum pellucidum dysplasia. Conclusions The manifestations of SBH patient complicated with OS and SPPD are epilepsy, mental retardation, growth retardation and nervous

  11. Familial band-shaped nodular keratopathy.

    Science.gov (United States)

    Meisler, D M; Tabbara, K F; Wood, I S; Alvarado, J A; Biswell, R

    1985-02-01

    A family is reported in which two brothers have a bilateral, symmetrical corneal disorder characterized by small yellowish to amber-colored globules arranged in a band-shaped configuration in the central superficial layers of the cornea. The globules have a similar clinical appearance to those found in Bietti's "band-shaped nodular dystrophy," a keratopathy that is nonfamilial, has an onset later in life, and initially involves the peripheral cornea. Light and electron microscopic studies of corneal tissue obtained from the proband showed that the globular deposits autofluoresce, that they stain black with Verhoeff's elastic stain, and that they correspond to an electron-dense material found within corneal epithelial cells and keratocytes and within the extracellular tissues of the anterior cornea. A third, younger brother appears to have the early corneal signs of the condition. Unlike the condition described by Bietti, the keratopathy we report is unique in its familial nature, early onset in life, and initial, marked central corneal involvement.

  12. Disturbances in the positioning, proliferation and apoptosis of neural progenitors contribute to subcortical band heterotopia formation.

    Science.gov (United States)

    Fitzgerald, M P; Covio, M; Lee, K S

    2011-03-10

    Cortical malformations are commonly associated with intractable epilepsy and other developmental disorders. Our studies utilize the tish rat, a spontaneously occurring genetic model of subcortical band heterotopia (SBH) associated with epilepsy, to evaluate the developmental events underlying SBH formation in the neocortex. Our results demonstrate that Pax6(+) and Tbr2(+) progenitors are mislocalized in tish(+/-) and tish(-/-)- neocortex throughout neurogenesis. In addition, mislocalized tish(-/-) progenitors possess a longer cell cycle than wild type or normally-positioned tish(-/-) progenitors, owing to a lengthened G(2)+M+G(1) time. This mislocalization is not associated with adherens junction breakdown or loss of radial glial polarity in the ventricular zone (VZ), as assessed by immunohistochemistry against phalloidin (to identify F-actin), aPKC-λ and Par3. However, vimentin immunohistochemistry indicates that the radial glial scaffold is disrupted in the region of the tish(-/-) heterotopia. Moreover, lineage tracing experiments using in utero electroporation in tish(-/-) neocortex demonstrate that mislocalized progenitors do not retain contact with the ventricular surface and that ventricular/subventricular zone (SVZ) progenitors produce neurons that migrate into both the heterotopia and cortical plate (CP). Taken together, these findings define a series of developmental errors contributing to SBH formation that differs fundamentally from a primary error in neuronal migration.

  13. 超声引导下射频消融治疗结节性甲状腺肿46例报告%Doppler Ultrasound-guided Radiofrequency Ablation for Nodular Goiter: Report of 46 Cases

    Institute of Scientific and Technical Information of China (English)

    刘金涛; 郭文斌; 杨世财; 葛述科

    2012-01-01

    目的 探讨超声引导下射频消融( radiofrequency ablation,RFA)治疗结节性甲状腺肿的临床效果. 方法 2009年6月~ 2010年9月对46例甲状腺良性结节在局部麻醉下行超声引导下RFA治疗,在颈部皮肤取1 mm切口,切开皮肤及皮下组织,将射频针穿刺在结节的中心部位开启射频,应用能量为4~6W,其中心温度可达95℃. 结果 均成功行RFA,术中无明显并发症发生,1例出现穿刺部位感染.RFA术后6个月47.8% (22/46)患者结节全部吸收,26.1% (12/46)结节体积较术前缩小≥50%,26.1% (12/26)结节体积较术前缩小25% ~ 50%. 结论 超声引导下RFA治疗结节性甲状腺肿疗效好、微创优势明显,是一种值得推广的手术方法.%Objective To explore the efficacy of Doppler ultrasound-guided radiofrequency ablation ( RFA) for benign thyroid nodules. Methods From June 2009 to September 2010, we performed RFA under the guidance by Doppler ultrasonography on 46 patients with benign thyroid nodules. We made a 1-mm incision at the neck, cut the skin and subcutaneous tissues, and then inserted a radiofrequency needle into the center point of the nodules for RFA (4-6 W, center temperature 95 ℃ ). Results The procedure was completed in all the patients without causing severe complications. One patient developed infection at the puncture site. Six months after the RFA, 22 of the patients (47. 8% ) had all the nodules disappeared, 12 patients (26. 1% ) had the size of the nodules reduced by ≥50% , while in the other 12 patients the nodules were reduced by 25% -50% . Conclusions RFA is a safe, effective, and minimally invasive method for the treatment of nodular goiter. It is worth being widely used.

  14. Lymphoid nodular hyperplasia in a patient with severe combined immunodeficiency disease; Hiperplasia nodular linfoide en un paciente con inmunodeficiencia combinada grave

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez-Alegre, M. L.; Casanova, A.; Delgado, J.; Relanzon, S. [Hospital General Universitario Gregorio Maranon. Madrid (Spain)

    2001-07-01

    We describe a case of lymphoid nodular hyperplasia in a woman with severe combined immunodeficiency disease. the patient complained of constipation and episodes of abdominal pain, and examination revealed the presence of a large abdominal mass. The diagnosis was suspected on the basis of the initial radiological studies, but intestinal biopsy was necessary to rule out lymphomatous involvement. We point out the radiological features of this entity which, despite the fact that it may be a chance finding of no pathological significance, requires special attention, especially in immuno deficient individuals. (Author) 10 refs.

  15. FINE NEEDLE ASPIRATION CYTOLOGY AND HISTOPATHOLOGICAL CORRELATION OF NODULAR LESIONS OF THYROID: A STUDY

    Directory of Open Access Journals (Sweden)

    Shanthi

    2016-06-01

    Full Text Available piration Cytology in diagnosing the nature of thyroid lesions and comparing its results with histopathological findings. It was observed that FNAC is the investigation of choice in thyroid swellings and has excellent patient compliance, is simple and quick to perform in outpatient department and is cost effective with high degree of sensitivity and specificity. MATERIALS AND METHODS This is a retrospective study comparing cytology and corresponding histopathology reported in 60 cases of nodular thyroid lesions. The statistical analysis included sensitivity and specificity and accuracy in nodular thyroid lesions. RESULTS On cytological examination of the 671 cases, initial diagnosis/impression as non-neoplastic was given for 616 cases (91.80% and neoplastic for 47 cases (7.00% in which 17 cases (36.17% were benign and 28 cases (59.57% were given as malignant, 5 cases were reported as suspicious for malignancy and for 5 cases samples were inadequate for a cytological diagnosis. Sensitivity of FNA in non-neoplasm lesions 92.5%, follicular neoplasm 87.5% and malignancies 68.42%. The specificity of FNA in non-neoplastic lesion is 100%, in follicular neoplasm is 96% and in malignancy 100%. Accuracy in FNAC for non-neoplastic lesion and follicular neoplasm 95% and malignancy 91%. CONCLUSION It was observed that FNAC is a vital reliable tool, safe and accurate method to evaluate nodular thyroid lesions. It greatly influences the treatment decision. In spite of accuracy of FNAC in differentiating between benign and malignant lesions, certain pitfalls were highlighted in diagnosing follicular neoplasm, which constitutes a “Gray zone” and papillary carcinoma and follicular carcinoma. We hope that a better understanding of these pitfalls wound help avoiding them in future and will contribute to better patient care.

  16. Microstructural Characterization of Nodular Ductile Iron

    Energy Technology Data Exchange (ETDEWEB)

    Springer, H K

    2012-01-03

    The objective of this study is to quantify the graphite particle phase in nodular ductile iron (NDI). This study provides the basis for initializing microstructure in direct numerical simulations, as part of developing microstructure-fracture response models. The work presented here is a subset of a PhD dissertation on spall fracture in NDI. NDI is an ideal material for studying the influence of microstructure on ductile fracture because it contains a readily identifiable second-phase particle population, embedded in a ductile metallic matrix, which serves as primary void nucleation sites. Nucleated voids grow and coalesce under continued tensile loading, as part of the micromechanisms of ductile fracture, and lead to macroscopic failure. For this study, we used 2D optical microscopy and quantitative metallography relationships to characterize the volume fraction, size distribution, nearest-neighbor distance, and other higher-order metrics of the graphite particle phase. We found that the volume fraction was {Phi} = 0.115, the average particle diameter was d{sub avg} = 25.9 {mu}m, the Weibull shape and scaling parameters were {beta} = 1.8 and {eta} = 29.1 {mu}m, respectively, the (first) nearest neighbor distance was L{sub nn} = 32.4 {mu}m, the exponential coefficients for volume fraction fluctuations was A{sub {Phi}} = 1.89 and B{sub {Phi}} = -0.59, respectively. Based on reaching a coefficient-of-variation (COV) of 0.01, the representative volume element (RVE) size was determined to be 8.9L{sub nn} (288 {mu}m).

  17. Progressive nodular histiocytosis associated with eale′s disease

    Directory of Open Access Journals (Sweden)

    Abhilasha Williams

    2015-01-01

    Full Text Available Progressive nodular histiocytosis (PNH is a rare normolipemic macrophage disorder and belongs to a subgroup of non-Langerhans cell histiocytosis (LCHs which is characterized by a progressive course with no sign of spontaneous resolution but without systemic involvement. We report a 30-year-old gentleman who presented with skin lesions all over the body associated with gradual bilateral painless loss of vision. On examination, approximately 30 to 40, skin-colored, firm, non-tender papules and nodules were noted over the body especially on the face and trunk. A skin biopsy revealed a cellular tumor in the dermis composed of oval to spindle-shaped cells, positive for CD68 but negative for S-100, CD34, CD21, CD35 and HMB45, supporting a diagnosis of spindle cell histiocytic tumor. Ophthalmic examination revealed a generalized arteriolar attenuation in both eyes. He received Tab Imatinib 400 mg OD for 5 months followed by Tab Pazopanib 800 mg OD for 4 months and both the drugs were stopped due to lack of any response in the skin lesions. We report this case due to its rarity, characteristic clinical presentation, and its association with Eale′s disease. Primary treatment remains surgical excision of bothersome lesions and optimal systemic treatment is still unknown.

  18. [Brunners gland hiperplasia. Report of two cases].

    Science.gov (United States)

    Padilla Ruiz, Maykel

    2014-04-01

    Brunner's gland hyperplasia is an infrequent benign injury located on the first or second portion of the duodenum. The disease spectrum includes diffuse nodular hyperplasia, circumscribed nodular hyperplasia, and Brunner's gland adenoma. We report two cases, one with an adenoma of Brunner's glands as a duodenal polyp and the other as a diffuse nodular hyperplasia of the duodenal bulb.

  19. Compromiso nodular hepático secundario a mieloma múltiple Nodular hepatic lesions secondary to multiple myeloma

    Directory of Open Access Journals (Sweden)

    Fernando J. Vázquez

    2010-08-01

    Full Text Available El mieloma múltiple (MM es una enfermedad maligna caracterizada por una proliferación clonal de células plasmáticas atípicas en la médula ósea, que produce una inmunoglobulina (Ig con estructura homogénea en la sangre y/o en la orina (cadenas livianas. El compromiso del parénquima hepático con masa ocupante en los pacientes con MM es excepcional. Describimos 3 casos clínicos confirmados histológicamente. La ecografía y la tomografía computarizada tienen una sensibilidad intermedia y las imágenes no son patognomónicas, por lo tanto es necesaria la confirmación a través de la biopsia. Se desconoce la implicancia pronóstica de este hallazgo.Multiple myeloma is characterized by the neoplastic proliferation of a single clone of plasma cells producing a monoclonal immunoglobulin. Myelomatous nodular lesions of the liver are infrequent. We describe 3 cases with histological confirmation and we review the bibliography.

  20. Clinical and neuroimaging findings in children with gray matter heterotopias: A single institution experience of 36 patients.

    Science.gov (United States)

    Hung, Po-Cheng; Wang, Huei-Shyong; Chou, Ming-Liang; Lin, Kuang-Lin; Hsieh, Meng-Ying; Wong, Alex M-C

    2016-09-01

    To describe the clinical spectrum and neuroimaging features of childhood gray matter heterotopias in a single tertiary hospital in Taiwan. We retrospectively reviewed the medical records and magnetic resonance images (MRI) of 36 patients with gray matter heterotopias, 19 females and 17 males, between July 1999 and June 2014. The MRI morphologic findings of gray matter heterotopias were recorded along with the presence of associated cerebral malformations. The clinical, electrophysiological and associated systemic malformation data were also recorded. A total of 36 patients were included in the study. Their ages ranged from 1 month to 18 years with a mean age of 3 years 6 months. According to the location of gray matter heterotopias, patients were classified into two groups: periventricular (26) and band (10). The phenotypic spectrum in our population differed from that described previously. In the periventricular group, additional cerebral malformations were found in 18/26 (69%) and systemic malformations in 14/26 (54%). In the band group, additional cerebral malformations were found in 5/10 (50%) and systemic malformations in 2/10 (20%). The majority of patients had developmental delay and intellectual deficit. Twenty-two patients suffered from epileptic seizures with 12 developing refractory epilepsy. In periventricular heterotopias, the most common associated cerebral malformation was ventriculomegaly, followed by agenesis of corpus callosum. Congenital heart disease was the most common additional systemic malformation. However, the most common associated cerebral malformation was pachygyria in band form. The majority of patients had developmental delay, intellectual deficit, especially in band heterotopias. Copyright © 2016 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

  1. Mechanical Characterization of Nodular Ductile Iron

    Energy Technology Data Exchange (ETDEWEB)

    Springer, H K

    2012-01-03

    The objective of this study is to characterize the strength and fracture response of nodular ductile iron (NDI) and its underlying ferritic matrix phase. Quasistatic and split Hopkinson pressure bar (SHPB) compression tests were performed on NDI and a model material for the NDI matrix phase (Fe-Si alloy). Smooth and notch round bar (NRB) samples were loaded in tension until fracture to determine strain-at-failure with varying stress triaxiality. Multiple tests were performed on each small and large smooth bar samples to obtain fracture statistics with sample size. Fracture statistics are important for initializing simulations of fragmentation events. Johnson-Cook strength models were developed for the NDI and the Fe-Si alloy. NDI strength model parameters are: A = 525 MPa, B = 650 MPa, n = 0.6, and C = 0.0205. The average SHPB experimental strain-rate of 2312/s was used for the reference strain-rate in this model. Fe-Si alloy strength model parameters are: A=560 MPa, B = 625 MPa, n = 0.5, and C = 0.02. The average SHPB experimental strain-rate of 2850/s was used for the reference strain-rate in this model. A Johnson-Cook failure model was developed for NDI with model parameters: D{sub 1} = 0.029, D{sub 2} = 0.44, D{sub 3} = -1.5, and D{sub 4} = D{sub 5} = 0. An exponential relationship was developed for the elongation-at-failure statistics as a function of length-scale with model parameters: S{sub f1} = 0.108, S{sub f2} = -0.00169, and L{sub m} = 32.4 {mu}m. NDI strength and failure models, including failure statistics, will be used in continuum-scale simulations of explosively-driven ring fragmentation. The Fe-Si alloy strength model will be used in mesoscale simulations of spall fracture in NDI, where the NDI matrix phase is captured explicitly.

  2. Nodular amyloidosis of the lung and the breast mimicking breast carcinoma with pulmonary metastasis.

    Science.gov (United States)

    Liaw, Y S; Kuo, S H; Yang, P C; Chen, C L; Luh, K T

    1995-05-01

    Nodular amyloidosis of the breast and lung is a rare condition of unknown aetiology. The disease runs a benign course, but offers a diagnostic problem due to nonspecific histological features. We describe the case of a 56 year old woman with a 5 year history of multiple nodules of both lungs and left breast, clinically mimicking breast carcinoma with pulmonary metastasis. To our knowledge, this is the first case of cytologically proven amyloidosis diagnosed by ultrasound-guided percutaneous transthoracic fine-needle aspiration of pulmonary nodules.

  3. Amiloidose pulmonar: relato de caso de achado radiológico da apresentação nodular em grande fumante Pulmonary amyloidosis: radiographic finding of nodular opacities in a heavy smoker

    Directory of Open Access Journals (Sweden)

    Jorge Montessi

    2007-06-01

    Full Text Available A amiloidose pulmonar é uma doença rara, caracterizada pelo depósito extracelular de proteínas fibrilares no pulmão. Amiloidose é um termo genérico para grupos heterogêneos de doenças, incluindo doença de Alzheimer e diabetes mellitus tipo II. Apresenta-se no aparelho respiratório sob as formas traqueobrônquica, nodular pulmonar e septal alveolar (parenquimatosa difusa. Relata-se o caso de uma mulher, tabagista (20 anos/maço, portadora de amiloidose nodular pulmonar, diagnosticada através de exames pré-operatórios à realização de colecistectomia videolaparoscópica.Pulmonary amyloidosis is a rare disease, characterized by extracellular deposition of fibrillary protein in the lungs. Amyloidosis is a generic term for a heterogeneous group of diseases, including Alzheimer's disease and type 2 diabetes mellitus. In the respiratory system, it appears in various forms: tracheobronchial; nodular pulmonary; and alveolar septal (diffuse parenchymal. We present the case of a woman who was a 20 pack-year smoker and had nodular pulmonary amyloidosis, as diagnosed through tests performed prior to laparoscopic cholecystectomy.

  4. Neural Progenitor Cells Undergoing Yap/Tead-Mediated Enhanced Self-Renewal Form Heterotopias More Easily in the Diencephalon than in the Telencephalon.

    Science.gov (United States)

    Saito, Kanako; Kawasoe, Ryotaro; Sasaki, Hiroshi; Kawaguchi, Ayano; Miyata, Takaki

    2017-09-06

    Spatiotemporally ordered production of cells is essential for brain development. Normally, most undifferentiated neural progenitor cells (NPCs) face the apical (ventricular) surface of embryonic brain walls. Pathological detachment of NPCs from the apical surface and their invasion of outer neuronal territories, i.e., formation of NPC heterotopias, can disrupt the overall structure of the brain. Although NPC heterotopias have previously been observed in a variety of experimental contexts, the underlying mechanisms remain largely unknown. Yes-associated protein 1 (Yap1) and the TEA domain (Tead) proteins, which act downstream of Hippo signaling, enhance the stem-like characteristics of NPCs. Elevated expression of Yap1 or Tead in the neural tube (future spinal cord) induces massive NPC heterotopias, but Yap/Tead-induced expansion of NPCs in the developing brain has not been previously reported to produce NPC heterotopias. To determine whether NPC heterotopias occur in a regionally characteristic manner, we introduced the Yap1-S112A or Tead-VP16 into NPCs of the telencephalon and diencephalon, two neighboring but distinct forebrain regions, of embryonic day 10 mice by in utero electroporation, and compared NPC heterotopia formation. Although NPCs in both regions exhibited enhanced stem-like behaviors, heterotopias were larger and more frequent in the diencephalon than in the telencephalon. This result, the first example of Yap/Tead-induced NPC heterotopia in the forebrain, reveals that Yap/Tead-induced NPC heterotopia is not specific to the neural tube, and also suggests that this phenomenon depends on regional factors such as the three-dimensional geometry and assembly of these cells.

  5. Nodular regenerative hyperplasia rarely leads to liver transplantation : A 20-year cohort study in all Dutch liver transplant units

    NARCIS (Netherlands)

    Meijer, Berrie; Simsek, Melek; Blokzijl, Hans; de Man, Robert A.; Coenraad, Minneke J.; Dijkstra, Gerard; van Nieuwkerk, Carin M. J.; Mulder, Chris J. J.; de Boer, Nanne K. H.

    2017-01-01

    Background: Nodular regenerative hyperplasia is an uncommon liver condition associated with several autoimmune disorders and drugs. The clinical symptoms of nodular regenerative hyperplasia vary from asymptomatic to severe complications of portal hypertension (nodular regenerative hyperplasia-syndro

  6. Study on numerical simulation of nodular graphite iron microstructure formation

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    In this paper, the mathematical and physical model was developed based on thermodynamics and solidification theory before the eutectoid transformation of nodular graphite iron occurred. The Local Element Substitute and Magnification Method was brought forward and 3-dimensional numerical simulation program based on the model and the new assistant algorithm was developed and used to calculate the samples. Results of calculation have good agreement with experimental data. To display the microstructure formation during solidification of nodular graphite iron, a 2-dimensional numerical simulation program combined with the result of the 3-dimensional numerical simulation of experimental samples was compiled.

  7. Recurrent nodular haemangiomas in Klippel-Trénaunay syndrome

    DEFF Research Database (Denmark)

    Illum, N; Winther Nielsen, H; Guldhammer Skov, B

    1992-01-01

    A one-year-old child had hypertrophy of the left leg and an unusual constellation of a naevus flammeus and superficial enlarged veins of the trunk together with successive appearance and involution since birth of numerous nodular elements located in the naevus and in the surrounding normal skin...

  8. Treatment of nasal ala nodular congenital melanocytic naevus with carbon dioxide laser and Q-switched Nd:YAG laser.

    Science.gov (United States)

    Zeng, Ying; Ji, Chenyang; Zhan, Kui; Weng, Weili

    2016-11-01

    Total excision of congenital melanocytic nevi (CMN) is not always feasible. We here present our experience of using carbon dioxide laser and Q-switched neodymium-doped yttrium-aluminum-garnet (Nd:YAG) laser to treat nodular CMN of the nasal ala. Q-switched Nd:YAG laser and/or carbon dioxide laser were used to treat eight cases of nasal ala nodular CMN. Carbon dioxide laser was utilized to ablate all visible melanocytic tissue within one session. Ablation was performed so as to reproduce the original anatomical contours as closely as possible. Recurrences were treated in the same way. Q-switched Nd:YAG laser was also used to irradiate all target lesions to achieve the desired end point within one session. The intervals between treatments were at least 8 weeks. Recurrence of melanocytic tissue, scar formation, pigmentation, depigmentation, and the degree of patient satisfaction were recorded at every visit. Two of the eight patients were treated with Q-switched Nd:YAG laser. Although, the lesion lightened in one of them, the hyperplastic tissue persisted. Eventually, these two patients, along with the remaining six patients, were successfully treated with a carbon dioxide laser. We recommend carbon dioxide laser treatment for nodular nasal CMN. This simple treatment does not involve skin flap transplantation and has good cosmetic outcomes. Although Q-switched Nd:YAG laser does lighten some nasal nodular CMNs, it does not eradicate the hyperplastic tissue, and is therefore not an effective treatment for nodular nasal CMN.

  9. Benign and malignant nodular thyroid disease in acromegaly. Is a routine thyroid ultrasound evaluation advisable?

    Directory of Open Access Journals (Sweden)

    Jordi L Reverter

    Full Text Available Data on the prevalence of benign and malignant nodular thyroid disease in patients with acromegaly is a matter of debate. In the last decade an increasing incidence of thyroid cancer has been reported. The aim of this study was to evaluate the prevalence of goiter, thyroid nodules and thyroid cancer in a large series of patients with acromegaly with a cross-sectional study with a control group. Six Spanish university hospitals participated. One hundred and twenty three patients (50% men; mean age 59±13 years; disease duration 6.7±7.2 years and 50 controls (51% males, mean age 58±15 years were studied. All participants underwent thyroid ultrasound and fine needle aspiration. Cytological analysis was performed in suspicious nodules between 0.5 and 1.0 cm and in all nodules greater than 1.0 cm. Goiter was more frequently found in patients than in controls (24.9 vs. 8.3%, respectively; p<0.001. Nodular thyroid disease as well as nodules greater than 1 cm were also more prevalent in acromegalic patients (64.6%, vs. 28.6%, p<0.05 and 53.3 vs. 28.6%, respectively; p<0.05, and all underwent fine needle aspiration. Suspicious cytology was detected in 4 patients and in none of the controls. After thyroidectomy, papillary thyroid carcinoma was confirmed in two cases (3.3% of patients with thyroid nodules, representing 1.6% of the entire group of patients with acromegaly (2.4% including a case with previously diagnosed papillary thyroid carcinoma. These data indicated that thyroid nodular disease and cancer are increased in acromegaly, thus justifying its routine ultrasound screening.

  10. MRI-findings of nodular lesions in an enlarged spleen, associated with visceral Leishmaniasis

    Energy Technology Data Exchange (ETDEWEB)

    Raeymaeckers, Steven, E-mail: Steven.Raeymaeckers@vub.ac.be [ZNA Middelheim, Lindendreef 1, 2020 Antwerpen (Belgium); Docx, Martine; Demeyere, Nathan [ZNA Middelheim, Lindendreef 1, 2020 Antwerpen (Belgium)

    2012-10-15

    Highlights: ► We confirm a previous report that infection with Leishmania can manifest multiple nodular lesions of the spleen. ► We confirm these lesions to be readily detectable with present imaging modalities. ► We affirm the fact that these lesions are hypoechoic on ultrasound, though in our case no hypoechoic halo was observed. ► We found these lesions to be hypodense on CT in the delayed phase after intravenous contrast administration. ► In addition to these previous findings we found that the spleen showed an inhomogeneous intensity on MRI; upon closer examination whilst scrolling through the T2-weighted sequences we can note multiple ill-defined and heterogeneous hypointense nodules. -- Abstract: We present a case of a 15-month-old Moroccan girl with fever of unknown origin, hepatosplenomegaly and multiple hypoechoic nodular splenic lesions that appear hypodense on CT. T2-weighted MRI sequences show a markedly inhomogeneous intensity of the parenchyma, seemingly caused by multiple ill-defined and heterogeneous hypointense nodules. Laboratory tests confirmed a recent infection with Leishmania, a parasite endemic to (sub)tropic regions. During and after therapy these lesions gradually resolved. To our knowledge this is the second published case in which different imaging modalities were able to demonstrate organ lesions associated with Leishmania. It is also the first report of MRI-findings associated with these lesions.

  11. The prevalence of thyroid cancers in surgically treated patients with nodular goiter in Şırnak city

    Directory of Open Access Journals (Sweden)

    Sevda Sert Bektaş

    2010-12-01

    Full Text Available Objectives: Iodine deficiency is still considered to be the major etiological factor for endemic goiter. The pathogenesis of the goiter in iodine deficient area caries different characteristics. The aim of this study investigate the prevalence of thyroid cancers and type of thyroid cancers in surgically treated patients with nodular goiter in Şırnak city where is iodine deficiency region.Materials and methods: Thyroid surgical materials which were sent to our department were screened retrospectively from the archives between the years 2009-2010. Thyroid resection was performed on 241 patients with nodular goiter in one year. We evaluated patients who received the diagnosis of thyroid carcinoma with histhopatological examination.Results: 222 of our patients (92.1% female and 19 (7.9% were male. The youngest patient 16 and the oldest patient was 80 years old and the average age is 40.9 ± 12.8. Histopathological examination of 197 (81.7% cases of nodular goiter, 31 (12.9% cases lymphocytic thyroiditis, 13 (5.4% patients had thyroid tumors. The three tumors on the 2 cases (0.8% benign, 11 (4.6% were malignant. As a type of cancer 1 (0.4% patients, follicular carcinoma-oncocytic variant, 10 (4.2% cases were papillary carcinoma.Conclusions: Iodine deficiency area in the province of Şırnak in patients with nodular goiter who underwent surgery for thyroid cancer rate of 4.6%, and most cancers is seen as a type of thyroid papillary carcinoma.

  12. Interhemispheric Lipoma, Callosal Anomaly, and Malformations of Cortical Development: A Case Series.

    Science.gov (United States)

    Niwa, Tetsu; de Vries, Linda S; Manten, Gwendolyn T R; Lequin, Maarten; Cuppen, Inge; Shibasaki, Jun; Aida, Noriko

    2016-04-01

    Intracranial lipomas are rare congenital malformations. The most common type of intracranial lipoma is the interhemispheric lipoma, which is frequently associated with callosal anomalies such as hypogenesis or agenesis of the corpus callosum. In contrast, interhemispheric lipomas are less often accompanied with malformations of cortical development (MCD). We report magnetic resonance imaging findings of three infants with an interhemispheric lipoma, associated with a callosal anomaly, and MCD: two infants with nodular interhemispheric lipoma, agenesis of the corpus callosum, and polymicrogyria, and one infant with interhemispheric curvilinear lipoma, hypoplasia of the corpus callosum, and heterotopias. An association was suggested regarding the occurrence of these malformations.

  13. Nodular goiter after occupational accidental exposure to radiation

    Energy Technology Data Exchange (ETDEWEB)

    Pisarev, M.A. [Radiobiology, National Atomic Energy Commission, Buenos Aires (Argentina); Human Biochemistry, Uninversity of Buenos Aires, School of Medicine, Buenos Aires (Argentina); Schnitman, M. [Center of Endocrinology and Metabolism, French Hospital C.Milstein, Buenos Aires (Argentina)

    2012-07-01

    In the present paper we present the consequences of an accidental occupational radiation exposure at a local hospital in Buenos Aires. Control at a local radiology service showed the lack of correct shielding in the X-ray equipment. The physicians and technicians (14 persons) exposed to radiation during 12 months were examined. The survey shows that: a) In 11 out of 14 radiation-exposed patients nodular goiter developed and an additional patient had diffuse goiter which means a goiter incidence of 85.7%; b) In 5 of the nodular goiter patients an increase in the size or the appearance of new nodules was observed along the follow-up period. No cancer was detected by FNA; c) Hypothyroidism was observed in 3/14 patients, and an additional patient had an abnormal TRH-TSH test, suggesting subclinical hypothyroidism; and d) Increased circulating antithyroid antibodies were found in one of the hypothyroid patients

  14. Pictures of focal nodular hyperplasia and hepatocellular adenomas

    Institute of Scientific and Technical Information of China (English)

    Christine; Sempoux; Charles; Balabaud; Paulette; Bioulac-Sage

    2014-01-01

    This practical atlas aims to help liver and non liver pa-thologists to recognize benign hepatocellular nodules on resected specimen. Macroscopic and microscopic views together with immunohistochemical stains illustrate typical and atypical aspects of focal nodular hyperplasia and of hepatocellular adenoma, including hepatocel-lular adenomas subtypes with references to clinical and imaging data. Each step is important to make a correct diagnosis. The specimen including the nodule and the non-tumoral liver should be sliced, photographed and all different looking areas adequately sampled for par-affin inclusion. Routine histology includes HE, trichrome and cytokeratin 7. Immunohistochemistry includes glu-tamine synthase and according to the above results ad-ditional markers such as liver fatty acid binding protein, C reactive protein and beta catenin may be realized to differentiate focal nodular hyperplasia from hepatocel-lular adenoma subtypes. Clues for differential diagnosis and pitfalls are explained and illustrated.

  15. Morphometric analysis of hepatocellular nodular lesions in HCV cirrhosis.

    Science.gov (United States)

    Vertemati, Maurizio; Moscheni, Claudia; Petrella, Duccio; Lamperti, Luca; Cossa, Mara; Gambacorta, Marcello; Goffredi, Maria; Vizzotto, Laura

    2012-04-15

    We generated a computerized morphometric model to evaluate and quantify the morphological features in large regenerative nodules (LRN), high-grade dysplastic nodules (HGDN) and hepatocellular carcinoma (HCC). Sixteen LRN, 10 HGDN and 16 HCC in HCV-cirrhotic livers were stained with H&E, smooth muscle actin, CD34, CD31 and reticulin to evaluate volume and surface fractions. On H&E stains, the most discriminatory features between LRN, HGDN and HCC were volume fraction and the number of hepatocyte nuclei in unit volume and hepatocyte nuclear/cytoplasmic ratio. On immunohistochemistry, volume fractions of capillarised sinusoids, capillary units and isolated arteries were significantly different among all groups and highest in HCC; surface fraction of reticulin was markedly decreased in HCC. Our morphometric model is an objective method for quantification of the morphological changes of the nodular lesions, and it could be applied to studies involving histological evaluation of the spectrum of nodular lesions arising in the cirrhotic liver.

  16. Low and high frequency fatigue tests of nodular cast irons

    Directory of Open Access Journals (Sweden)

    A. Vaško

    2017-01-01

    Full Text Available The paper deals with the comparison of fatigue properties of nodular cast iron at low and high frequency cyclic loading. The specimens from three melts of nodular cast iron with different microstructure and mechanical properties were used for experiments. Fatigue tests were carried out at low and high frequency sinusoidal cyclic push-pull loading (stress ratio R = –1 at ambient temperature (T = 20 ± 5 °C. Low frequency fatigue tests were carried out using the fatigue experimental machine Zwick/Roell Amsler 150HFP 5100 at frequency f ≈ 120 Hz; high frequency fatigue tests were carried out using the ultrasonic fatigue testing device KAUP-ZU at frequency f ≈ 20 kHz.

  17. Multiple myeloma presenting as hepatic nodular lesion.

    Science.gov (United States)

    de Vos, M; Druez, P; Nicaise, M; Ngendahayo, P; Sinapi, I; Mineur, P

    2012-01-01

    The diffuse infiltration by plasma cells in the liver is not uncommon in multiple myeloma (MM). However, a MM with hepatic mass is very unusual. We report a case of a 75-year-old male with hepatomegaly and a lesion occupying a voluminous space in the liver. A lambda light chain multiple myeloma was found in the check-up of this hepatic mass. We also provide a literature review.

  18. {sup 131}I treatment of nodular non-toxic goitre

    Energy Technology Data Exchange (ETDEWEB)

    Nygaard, B.; Faber, J.; Hegdeues, L.; Hansen, J.M. [Herlev Hospital (Denmark)

    1996-01-01

    The traditional treatment of a growing nodular non-toxic goitre has for many years been surgical resection or levothyroxine suppressive treatment. During recent years, several studies have reported promising results of {sup 131}I treatment in terms of thyroid size reduction. This review outlines the different treatment modalities on non-toxic nodular goitre with special emphasis on {sup 131}I treatment. By the term nodular goitre the authors include glands with solitary or multiple thyroid nodules with uptake on a scintiscan. At what point of the natural history of non-toxic multinodular goitre {sup 131}I therapy should be used is not clear. In principle, the best result is obtained in smaller goitres and it is possible that the best effect of {sup 131}I is seen if treatment is given to patients with diffuse goitre before these become nodular. However, then there is a potential risk to swing in the direction to where {sup 131}I is used in an indiscriminate way, since the prevalence of non-toxic multinodular goitre is much higher than that of hyperthyroidism. Although we have data on the long-term hazards of {sup 131}I treatment in hyperthyroidism in terms of risk of cancer, we have only follow-up periods of 5 to 10 years for non-toxic goitres in small groups of patients and no data regarding the long-term risk of high-dose {sup 131}I treatment (>600 MBq) for this condition. Ideally, long term randomized studies comparing the effect, side effect and cost-benefit of surgery as opposed to {sup 131}I treatment should be performed. Awaiting this, it is at present mandatory that each individual patient be given a choice of treatment after proper information. 44 refs.

  19. Epidemiology of nodular goitre. Influence of iodine intake.

    Science.gov (United States)

    Carlé, Allan; Krejbjerg, Anne; Laurberg, Peter

    2014-08-01

    More than one tenth of the world population is to some degree affected by goitre and most of these harbour nodules. The large differences in thyroid disease prevalence between populations may be caused by genetic and environmental factors. Among the latter, iodine deficiency seems by far to be the most important risk factor. Thus, nodular goitre is a condition predominantly seen in iodine deficient areas of the world. In the present review, we evaluated in detail autopsy and ultrasound studies of the thyroid gland. In autopsy studies, large thyroid volumes and high frequencies of goitres have been reported in countries affected by iodine deficiency. Many cross-sectional studies using thyroid ultrasound investigations have been performed world-wide and reported high thyroid volumes and goitre prevalences, and to some extent also high prevalences of thyroid nodules in iodine-deficient countries. Most of these goitres were classified as nodular goitres. On the other hand, few studies have shown that abundant iodine intake may lead to development of diffuse goitres, but world-wide this has been a minor problem compared with development of nodular goitres. In the past century we have observed a trend towards smaller thyroid glands, and hopefully less than 10% of the world population will experience goitre within a few decades.

  20. Nodular syphilitic scleritis masquerading as an ocular tumor.

    Science.gov (United States)

    Shaikh, Sufiyan I; Biswas, Jyotirmay; Rishi, Pukhraj

    2015-01-01

    Scleritis may be the initial or only presenting feature of systemic, autoimmune, or infectious disorders. Corticosteroids are the mainstay of treatment for immune-mediated scleritis. However, steroids could prove detrimental when used to treat infectious scleritis. Hence, infectious causes of scleritis should be ruled out. A 47-year-old male from central India presented with swelling, pain, and redness in the left eye since 2 months. The patient was diagnosed elsewhere as having an extraocular extension of intraocular tumor and advised radiation brachytherapy for the same. Clinical examination revealed nodular scleritis in the left eye. The patient did not have any systemic illness or complaints suggestive of connective tissue disease. Laboratory investigations ruled out the same. However, Venereal Disease Research Laboratory (VDRL) test was positive. Rapid plasma reagin (RPR) test and Treponema pallidum hemagglutination assay (TPHA) were also positive, confirming the diagnosis of syphilis. Ultrabiomicroscopy (UBM) and ultrasound scan of the eye ruled out intraocular tumor. Treatment was initiated with benzathine penicillin 2.4 million units per week for 3 weeks to which the patient responded remarkably well. Although rare, syphilis can present as nodular scleritis masquerading as ocular tumor. Syphilis must be considered in the list of etiological diagnoses in patients presenting with nodular scleritis, and testing for this disease should be a part of routine investigation in patients with scleritis.

  1. Surgical treatment of benign nodular goiter; report of 72 patients

    Directory of Open Access Journals (Sweden)

    Ediz YORGANCILAR

    2009-03-01

    Full Text Available Surgical resection is usually prefered for the treatment of benign nodular goiter. But the extention of thyroidectomy in the surgical management of benign nodular goiter still remains controversial. Seventytwo patients underwent thyroid surgery between April 2002- July2007 in Kızıltepe State Hospital Otorhinolaryngology Service. Of the patients 63 were women (%87.5, 9 were man (%12.5. The range of age was between 15-62 years and mean age was 36,5. Thirtynine patients had unilateral total lobectomy+ istmusectomy (%54.2, 11 patients had unilateral lobectomy+ isthmusectomy+contralateral subtotal lobectomy (Dunhill Procedure (%15.3, 20 patients had nearly total thyroidectomy (%27.8, 2 patients had total thyroidectomy (% 2.7. Three patients had seroma (%4.1, 2 patients had hemorrhage requiring operative hemostasis (%2.7, 1 patient had suture reaction(%1.3. Patients have not had permanent or temporary nervus laryngeus recurrens injury, hypoparathyroidism and infection.As a result more extent surgical resections must be preferred by the surgeon for the treatment of benign nodular goiter. The preferable surgical treatment of solitary nodules is lobectomy+isthmusectomy. The multinodular goiter must be treated with unilateral lobectomy+ isthmusectomy+contralateral subtotal lobectomy (Dunhill procedure when the remnant thyroid tissue is normal; otherwise nearly total or total thyroidectomy is preferable.

  2. Diagnostic accuracy of nodular gastritis for H. pylori infection

    Science.gov (United States)

    Romero-Flores, Juan L; Fernandez-Rivero, Justo A; Marroquín-Fabian, Erika; Téllez-Ávila, Félix I; Sánchez-Jiménez, Beatriz A; Juárez-Hernández, Eva; Uribe, Misael; Chávez-Tapia, Norberto C

    2017-01-01

    Background The term nodular is not included in the Sydney classification and there is no widely accepted histopathological definition. It has been proposed that the presence of antral nodularity could predict Helicobacter pylori (H. pylori) infection. The aim of this study was to determine the diagnostic accuracy of nodular gastritis (NG) for H. pylori infection after a rigorous standardization process, and to describe the associated histopathological characteristics. Materials and methods Endoscopic images of patients submitted to endoscopy with biopsy sampling were included. Endoscopic images were distributed among six endoscopists. The analysis was performed sequentially in three rounds: the first round assessed the interobserver variability, the second evaluated the intraobserver variability, and the third calculated the interobserver variability after training. A correlation analysis between endoscopic and histopathological findings was performed. Results A total of 917 studies were included. In the first analysis of interobserver variability, a poor kappa value (0.078) was obtained. The second evaluation yielded good intraobserver variability, with kappa values of 0.62–0.86. The evaluation of interobserver variability after training revealed an improvement in the kappa value of 0.42. A correlation was found between endoscopic images and histopathological reports. Conclusion There was a strong correlation between NG and H. pylori, but only after rigorous evaluation. The use of the term NG requires extensive standardization before it can be used clinically. PMID:28031716

  3. Transarterial embolisation of a large focal nodular hyperplasia, using microspheres, in a paediatric patient.

    Science.gov (United States)

    Oliveira, Catarina; Gil-Agostinho, Alfredo; Gonçalves, Isabel; Noruegas, Maria José

    2015-07-10

    Benign liver tumours are uncommon in children, haemangiomas being the most frequent. Focal nodular hyperplasia (FNH) represents about 2% of paediatric liver tumours. In children, as in adults, a conservative approach is generally recommended. However, large lesions (greater than 5 cm) are more frequent in the paediatric age group, and in these cases, as well as in growing lesions, surgical removal may be advised. Transarterial embolisation (TAE) has been a successful alternative option described in older patients, especially in cases where surgical removal is not possible. This minimally invasive procedure may also become an option in the paediatric group. The authors report the case of a boy with a large FNH treated with TAE using microspheres. 2015 BMJ Publishing Group Ltd.

  4. A Nodular Type of Subcutaneous Sarcoidosis: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Kyu Ho; Choi, Yun Sun; Kim, Byoung Suck; Joo, Jong Eun; Jung, Yoon Young; Cho, Young Kwon; An, Jin Kyung; Kim, Hyun Sook; Woo, Jung Joo [Eulji University Hospital, Daejeon (Korea, Republic of)

    2009-01-15

    Sarcoidosis is a granulomatous multisystemic disorder that rarely involves subcutaneous tissue. We describe the MR imaging findings of a subcutaneous sarcoidosis in a patient that presented with a nontender, palpable soft tissue mass on the left buttock, which was confirmed after surgical excision. The MR images showed the presence of a subcutaneous mass that breached the adjacent fascia with an irregular outline and homogeneous, slightly higher signal intensity than the surrounding muscle as seen on a T2-weighted image and with homogeneous enhancement after contrast injection. The lesion could not be differentiated from a sarcoma or a malignancy.

  5. Gastric heterotopia of rectum in a child: a mimicker of solitary rectal ulcer syndrome.

    Science.gov (United States)

    Al-Hussaini, Abdulrahman; Lone, Khurram; Al-Sofyani, Medhat; El Bagir, Asim

    2014-01-01

    Bleeding per rectum is an uncommon presentation in pediatric patients. Heterotopic gastric mucosa in the rectum is a rare cause of rectal bleeding. Here, we report a 3-year-old child with a bleeding rectal ulcer that was initially diagnosed and managed as a solitary rectal ulcer syndrome. After 1 month, the patient persisted to have intermittent rectal bleed and severe anal pain. Repeat colonoscopy showed the worsening of the rectal ulcer in size. Pediatric surgeon excised the ulcer, and histopathological examination revealed a gastric fundic-type mucosa consistent with the diagnosis of gastric heterotopia of the rectum. Over the following 18 months, our patient had experienced no rectal bleeding and remained entirely asymptomatic. In conclusion, heterotopic gastric mucosa of the rectum should be considered in the differential diagnosis of a bleeding rectal ulcer.

  6. Digital Cities in the making: exploring perceptions of space, agency of actors and heterotopia

    Directory of Open Access Journals (Sweden)

    Asne Kvale Handlykken

    2011-12-01

    Full Text Available

    This paper is an attempt to explore how we imagine, sense and experience spaces in digital cities by a study of the hybrid relations between digital media, users' bodies, architecture and the city. Digital and physical spaces of the city are intertwined, the city and urban places and things become sentient, embedded with sensors and digital infrastructure, challenging traditional notions of space, and how we perceive and experience urban space.  Crucial issues to explore are how interactions and agency operating amongst actors in these spaces; between sentient non-human actors, places and people?  How are spaces of interaction embedded in the city, what characterizes these spaces, can they be explored as heterotopias (Foucault? These processes are a mutual shaping of society and technology, where the role of the imaginary, of mental representations and creation are being transformed.

  7. Learning through Nomadic Interiors - Villa Rotonda through the lenses of Heterotopia

    DEFF Research Database (Denmark)

    Hvejsel, Marie Frier; Fisker, Anna Marie

    2015-01-01

    The question of the critical role of our built heritage to the complex and interdisciplinary processes that govern the current development of the built environment define a continuous challenge in interior studies and education: Can a study of the fundamental interior elements of Villa Rotonda fo...... in caramelized sugar can create a parallel learning space; an interior that make a utopian space possible....... in a series of nomadic interiors allowing the students to travel in time and place; from Palladio to the 14th Architectural Biennale and from Vincenza to Venice. In the paper we use Foucaults concept of Heterotopia to analyze how a window in 1:10 from the south façade of Villa Rotonda now re-designed...

  8. [Cartography of psychoactive heterotopias: a look at the medical, legal and social discourses regarding drug use].

    Science.gov (United States)

    Massó, Paloma

    2015-09-01

    This article traces a map of the social control of drugs through the politics of space, according to the Foucaultian concept of "heterotopia." Firstly, a brief genealogy of the use of psychotropic substances in different times and cultures is described, up to the introduction of the prohibitionist paradigm. Attention is paid to the way in which power has marked, separated and enclosed certain rituals and uses of pleasure in physical and symbolic sites. The itinerary is focused on the Spanish context to establish a dialogue between the various policies of space that have come into being and have overlapped in the construction and management of a problem which has been rendered an object to the gazes, mechanics and discourses of the medical, legal, and social fields. In this way, the intersections between the liminal spaces of drug use and the harm reduction paradigm are analyzed, including therapeutic strategies with prescribed drugs, from methadone programs to the new heroin programs.

  9. [Nodular regenerative hyperplasia as a complication of thiopurine treatment in a patient with inflammatory bowel disease].

    Science.gov (United States)

    Cohen-Ezra, Oranit; Avni, Yona; Morgenstern, Sara; Ben-Ari, Ziv

    2012-12-01

    Immunomodulator therapy with thiopurine analogues azathioprine or 6-mercaptopurine is commonly prescribed for the treatment of organ transplantation, inflammatory bowel disease, autoimmune diseases and malignancies. Hepatotoxicity due to thiopurine analogues usually presents as an increase in serum transaminase levels. Toxicity is usually not severe, and a dose reduction is effective in most patients. Nodular regenerative hyperplasia (NRH) is a very rare but potentially severe complication of thiopurine-containing therapy. NRH is often asymptomatic, neither biochemical nor molecular markers are indicative for NRH. The suspicion rises when there are clinical symptoms of portal hypertension or increases in transaminases levels orthrombocytopenia. Liver biopsy is essential for definitive diagnosis. This is a case report of a 40-year-old male patient with Crohn's disease who developed increased serum levels of liver enzymes and thrombocytopenia following the administration of thiopurine. Although treatment with thiopurine was discontinued, he has further progressed and presented with acute variceal bleeding due to portal hypertension. The diagnosis of nodular regenerative hyperplasia was proven by a liver biopsy. In conclusion, NRH is a very rare but potentially severe complication of thiopurine-containing immunosuppressive therapy for IBD.

  10. Horner's syndrome following a subtotal thyroidectomy for a benign nodular goitre.

    Science.gov (United States)

    Aslankurt, Murat; Aslan, Lokman; Colak, Mustafa; Aksoy, Adnan

    2013-06-13

    We present a case of Horner's syndrome occurring as a complication of thyroidectomy. A 42-year-old female patient presented with eyelid drop which developed immediately after thyroidectomy for goitre. Ophthalmic examination revealed eyelid ptosis, miosis and anhidrosis. Preoperative ultrasonography showed multiple isohyperechogenic solid nodules in each lobe, consistent with multinodular goitre. Therefore, the patient underwent subtotal thyroidectomy. The ophthalmic findings did not improve at the end of 6 months follow-up. Similar cases have been reported related to neck tumours or their surgery, mediastinum-located goitre and retropharyngeal abscess surgeries, but not after benign nodular goitre surgery. Several possible mechanisms have been proposed to explain this phenomenon; anatomical variations making the patient susceptible to damage to the sympathetic chain seem to be most likely in our patient.

  11. Combined hepatocellular and cholangiocellular carcinoma presenting with radiological characteristics of focal nodular hyperplasia

    Institute of Scientific and Technical Information of China (English)

    Inneke Willekens; Anne Hoorens; Caroline Geers; Bart Op de Beeck; Frederik Vandenbroucke; Johan de Mey

    2009-01-01

    Combined hepatocellular and cholangiocellular carcinoma (cHCC-CC) is a rare tumor type containing unequivocal elements of both hepatocellular carcinoma and cholangiocarcinoma that are intimately mixed.Although these tumors are usually considered to be more related to hepatocellular carcinoma than to cholangiocarcinoma, they sometimes, in contrast to hepatocellular carcinoma, contain a significant amount of fibrous stroma. This might in some cases explain atypical radiological features. We report a case of a cHCC-CC in a 47-year-old female that resembled focal nodular hyperplasia on Magnetic Resonance Imaging.Correlation of imaging and serum levels of α-fetoprotein and CA19.9 can help to make the correct diagnosis preoperatively.

  12. Carbides in Nodular Cast Iron with Cr and Mo

    Directory of Open Access Journals (Sweden)

    S. Pietrowski

    2007-07-01

    Full Text Available In these paper results of elements microsegregation in carbidic nodular cast iron have been presented. A cooling rate in the centre of the cross-section and on the surface of casting and change of moulding sand temperature during casting crystallization and its self-cooling have been investigated. TDA curves have been registered. The linear distribution of elements concentration in an eutectic grain, primary and secondary carbides have been made. It was found, that there are two kinds of carbides: Cr and Mo enriched. A probable composition of primary and secondary carbides have been presented.

  13. Fabricación de Fundición Nodular

    OpenAIRE

    Enríquez Berciano, José Luis; Tremps Guerra, Enrique

    2012-01-01

    Se trata de una monografía sobre aspectos prácticos de la fabricación de piezas moldeadas de fundición con grafito esferoidal, prestando mayor atención a los métodos de elaboración del nodular, especialmente en lo que concierne a los métodos de nodulización. Este trabajo no pretende ser original; simplemente se intenta hacer una revisión de la tecnología existente a fin de que sea de interés para todos los fundidores involucrados en esta parcela de la fundición.

  14. Carnivorous heterotopias

    DEFF Research Database (Denmark)

    Lapina, Linda; Leer, Jonatan

    2016-01-01

    The past years have seen an upsurge of burger- and barbecue restaurants in a Copenhagen gastronomic scene otherwise dominated by trends towards sustainability, ‘wholesome’, local and organic food. In these new spaces, meat is glorified and consumed materially and symbolically (through design and ...

  15. Carnivorous heterotopias

    DEFF Research Database (Denmark)

    Lapina, Linda; Leer, Jonatan

    2016-01-01

    The past years have seen an upsurge of burger and barbecue restaurants in a Copenhagen gastronomic scene otherwise dominated by trends toward sustainability, ‘wholesome’, local and organic food. In these new spaces, meat is glorified and consumed materially and symbolically (through design and de...

  16. Fragile heterotopias

    DEFF Research Database (Denmark)

    Sievers, Silla Marie Mørch

    2016-01-01

    aspects such as solidarity and a new economy that is fundamentally different from capitalist market economy. This study takes up these discussions by relating them to how social entrepreneurship is enacted in practice. The study was conducted as ethnographic fieldwork in a Danish voluntary organization......Social entrepreneurship has been promoted as a way to create community development. However, social entrepreneurship is a contested field of research. Critics tend to stress that social entrepreneurship is merely a crystallization of market-oriented neoliberal agendas, whereas proponents emphasize...... involved in social work and work integration and focuses on how dilemmas regarding social and economic goals are handled in the everyday practice. The findings of the study show that, rather than representing either a market-oriented or a solidarity-oriented approach in pure form, the organization...

  17. Heterotopia, Overview

    DEFF Research Database (Denmark)

    Kharlamov, Nikita

    2014-01-01

    The first-person perspective is a central concept of critical psychology trying to make psychological processes and the subjective dimension of human life understandable. The concept refers to the point of view of the “I” as the way in which a human subject has access to herself/himself and the w......The first-person perspective is a central concept of critical psychology trying to make psychological processes and the subjective dimension of human life understandable. The concept refers to the point of view of the “I” as the way in which a human subject has access to herself....../himself and the world and to her/his experiences, emotions, thoughts, and actions. The concept builds on a socio-materially situated understanding of the human being and stands in opposition to mainstream psychologies which conduct their research from an external – third-person – perspective. From such a view from...... above, or as critics argue, from “nowhere,” psychological phenomena and human life can only be understood in an abstract and reduced form. The individual appears one-sidedly as an effected and conditioned being, and the concrete reality of human subjectivity and agency, the active and acting side...

  18. Transarterial embolization (TAE) for the treatment of hepatocellular carcinoma (HCC) - The diagnostic value of Lipodol CT for detection of small nodular HCC

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jae Hyung; Choi, Byung Ihn; Cho, Kil Ho; Kim, Seung Hyup; Lee, Won Jae; Do, Yeong Soo; Kim, Won Hong; Shin, Myung Jin; Han, Man Chung [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1988-04-15

    In the Far East including Korea, the hepatocellular carcinoma (HCC) is common and its prognosis is very poor unless the malignancy is detected early and resected radically. TAE of HCC was done in 136 patients, from February, 1987 to October, 1987, in the Department of Diagnostic Radiology, Seoul National University Hospital. Among these 136 patients 30 had pre-angiographic CT, angiography with lipiodol infusion in hepatic artery, and post-angiographic lipiodol CT. Authors compared the detectability of small tumor nodules (less than 1cm in diameter) between CT, angiography, and lipiodol CT in these 30 patients. The results were as follows: 1. The 30 cases are composed of 14 of solitary nodular, 10 of multinodular, and 6 of diffuse type viewed on pre-angiographic CT. 2. Lipiodol CT is superior in detection of small nodule to conventional CT in 10 cases. (1) Six among 14 cases of solitary nodular type show another nodules on lipiodol CT (2) Four in 10 cases of multinodular type represent additional nodules. 3. Lipiodol CT is also superior in small nodule detection to angiography in 7 cases, and is very useful in detection of tumors at subdiaphragmatic portion, resection margin, and periphery of the liver. 4. It is very difficult to compare the detectability of small nodules between CT, angiography, and lipiodol CT in diffuse type (6 cases). And there is no difference in number of detected nodules in 9 cases of nodular type (24 cases)

  19. Nodular Regenerative Hyperplasia and Portal Hypertension in a Patient with Coeliac Disease

    Directory of Open Access Journals (Sweden)

    Erwin Biecker

    2011-01-01

    Full Text Available Nodular regenerative hyperplasia (NRH of the liver is often associated with rheumatologic or lymphoproliferative disorders and a cause of portal hypertension in some patients. We report the case of a 71-year-old patient with celiac disease and unexplained portal hypertension. Biopsy of the liver revealed NRH as the underlying cause. The patient did not suffer from an autoimmune, rheumatologic or lymphoproliferative disease. A thrombophilic disorder that might cause NRH was ruled out. Celiac disease is often associated with mild elevation of liver enzymes and steatosis of the liver, but the association with NRH was described in only a few patients. We discuss the possible relationship of celiac disease and NRH.

  20. Rheumatoid pleural effusion with nodular pleuritis. A rare presentation of rheumatoid arthritis.

    Science.gov (United States)

    Emmungil, H; Yıldız, F; Gözükara, M Y; Açıkalın, A

    2015-02-01

    Rheumatoid pleural effusion and lung nodules are unusual complications of rheumatoid disease that typically present subsequently to other more common manifestations of rheumatoid illness. However, these complications may occasionally occur before or concurrently with the development of joint manifestations of disease. We report the case of a 41-year-old female patient with rheumatoid pleural effusion and lung nodule arising simultaneously with the onset of joint symptoms. The patient underwent thoracentesis followed by video-assisted thoracoscopic biopsy to result in a diagnosis of rheumatoid pleuritis and nodular disease. A high index of suspicion and coexistence of the cytologic and histopathologic effusion picture characteristic of rheumatoid pleuritis are of clinical importance in making a diagnosis.

  1. 脾脏硬化性血管瘤样结节性转化1例临床病理观察并文献复习%Sclerosing angiomatoid nodular transformation of spleen:a report of one case

    Institute of Scientific and Technical Information of China (English)

    张晓玲; 郭效忠; 王秀荣; 苗玉; 邢荣格

    2012-01-01

    目的:报道1例少见的脾硬化性血管瘤样结节性转化(SANT),以提高对该病变的认识.方法:对1例SANT的临床、病理特征、免疫组化表达及术后随访情况进行分析并复习文献.结果:脾SANT具有众多由环靶状纤维组织围绕的肉芽肿样结节,伴有结节间不同程度硬化的间质.肉芽肿样结节内细胞呈卵圆形、短梭形,胞质相对丰富,部分细胞胞质内可形成含红细胞的腔隙,细胞间还穿插有衬覆肥胖内皮细胞的枝芽状毛细血管及相对扩张的窦隙样血管腔隙.免疫组化显示结节内不同血管样结构有3种不同的免疫组化表达.结论:SANT是脾具有特征性改变的一种良性病变,临床上易与脾脏恶性肿瘤混淆,病理上易与炎性假瘤、错钩瘤等混淆,诊断依靠病理组织学表现及免疫组化特点.行脾切除术可治愈,预后良好.%Objective:To report 1 case of sclerosing angiomatoid nodular transformation( SANT) of spleen. Methods : The clinical manifestations, pathology, expression of immunohistochemistry, and the follow up of 1 case of SANT was analyzed, and the related literature was reviewed. Results:The morphological features of SANTs were as follows; multiple nodules in a granuloma — like appearance were surrounded by a prominent shell of concentrically deposited fibers , and in variably fibrosclerotic stroma. There were spindly or ovoid cells in the nodules which had plenty of cytoplasm and indistinct cell borders. Some of them had vascular spaces in cytoplasm and could hold red cells in it. Furthermore , there were variable shapes of vascular spaces lined by plump endothelial cells interspersed in nodules. Im-munostaining revealed there were 3 distinct types of vessels in the nodule. Conclusion: SANT is a benign lesion of spleen which had a remarkably characteristic appearance. However there are few literatures about it in the past and it might be mistaken as other diseases of spleen such as inflammatory

  2. Nodular fasciitis: A pseudomalignant clonal neoplasm characterized by USP gene rearrangements and spontaneous regression

    LENUS (Irish Health Repository)

    Hennebry, Jennifer

    2017-01-01

    Introduction: Nodular fasciitis (NF) is a rapidly growing, self-limited, myofibroblastic neoplasm that typically arises in subcutaneous tissues of young adults and regresses spontaneously. Nodular fasciitis mimics sarcoma on clinical, radiological, and histological grounds and is usually, diagnosed following excision.\\r\

  3. [A patient with muscular torticollis caused by nodular fasciitis in the sternocleidomastoid muscle (SCM)].

    Science.gov (United States)

    Hemmi, Shoji; Murakami, Tatufumi; Shirabe, Teruo; Sunada, Yoshihide

    2002-09-01

    Nodular fasciitis is a benign pseudosarcomatous proliferative lesion which is frequently misdiagnosed as malignant tumor clinically and microscopically. It usually occurs as a rapidly enlarging subcutaneous mass on the upper extremities, especially on the forearm. Here we report a patient showing muscular torticollis caused by nodular fasciitis in the sternocleidomastoid muscle (SCM). A 17-year-old woman was hospitalized because of rapidly progressive torticollis. The right SCM was markedly enlarged and firm on palpation. Muscle biopsy taken from the right SCM revealed massive proliferation of spindle shaped fibroblasts infiltrating into the endomysium. These findings coincided with the intramuscular nodular fasciitis. However, different from typical nodular fasciitis, no apparent nodule formation was found in this patient. Instead, diffuse proliferative lesion extended widely into the neck soft tissue. To our knowledge, this is the first report of muscular torticollis caused by nodular fasciitis involving the SCM.

  4. 端坐位对经外周静脉留置中心静脉导管异位至颈内静脉的复位效果观察%The role of sitting-up-straight position on correction of PICC heterotopia in internal jugular vein

    Institute of Scientific and Technical Information of China (English)

    邓德琴; 赵加全; 韩兴平

    2014-01-01

    Objective To study the role of sitting-up-straight position on correction of peripherally inserted central catheter(PICC)heterotopia in internal jugular vein.Methods 104 cases with PICC heterotopia in internal jugular vein were collected, and randomly divided into the observation group and the control group, 52 cases in each group. The patients with PICC heterotopia in the observation group were instructed to take the position of sitting up straight, while the control group were in horizontal position.Results The reduction rate of observation group was 98.08%(51/52), which was significantly higher than the control group of 94.23%(49/52).Conclusion sitting-up-straight position on correction of peripherally inserted central catheter(PICC)heterotopia in internal jugular vein is simple and convenient, and good for higher reduction rate.%目的:研究分析端坐位对经外周静脉留置中心静脉导管(PICC)异位至颈内静脉复位的临床效果。方法选取2011年3月~2013年11月治疗采取PICC置管且导管异位至颈内静脉复位者104例,随机将其分成观察组与对照组两组,每组52例,对照组患者选择平卧位复位;观察组患者选择端坐位复位。结果观察组患者复位的成功率为98.08%(51/52),明显高于对照组的94.23%(49/52),差异有统计学意义(P<0.05)。结论端坐位对PICC导管异位至颈内静脉的复位成功率更高。

  5. “Bugabug ang dagat” (Rough seas: Experiencing Foucault’s heterotopia in fish trading houses

    Directory of Open Access Journals (Sweden)

    Nelson N. Turgo

    2012-06-01

    Full Text Available Places in the contemporary world are subjected to the workings of differentiating logics, foremost of which is globalization and to the other end, the counter-logic of localization, which results in, amongst others, the instantiation of differing spaces. These spaces, oftentimes co-existing and overlapping, are a result of contrapuntal forces, enacting their own colonization of places by people of varying interests. This article explores the other uses of kumisyunan (fish trading houses by magririgaton (fish vendors from a small fishing community in Quezon province that “simultaneously represent, contest, and invert” the very purpose and nature of the places’ rationale: fish trading. Heterotopia will be deployed in this article to further the ends of how a particular place could be inhabited by a number of spaces or exhibit alternate spatial possibilities and display a plethora of spatial practices within one singular location at different times in a particular spatial and temporal context. The article hopes to contribute to the further understanding of how everyday life and place is lived and reproduced in the variegated geographies of globalization in a developing economy like the Philippines.

  6. Utopia, heterotopia e nostalgia na performance dublada de música pop

    Directory of Open Access Journals (Sweden)

    Alan Mangabeira Mascarenhas

    2016-09-01

    Full Text Available Refletir fãs no cenário atual traz à tona uma visão antropológica de uma experiência estética que parece destacar a nostalgia dos consumidores da narrativa do ídolo. Neste trabalho, partimos da hipótese de que é a nostalgia um dos principais elos que mantém um fandom de música pop através da narrativa de seu ídolo no palco e fora dele. Propomos uma análise do show-fixo, que aqui chamamos de “monumento”, o “Piece of Me”, no qual a performer Britney Spears rememora momentos de sua carreira no teatro do Planet Hollywood em Las Vegas fazendo uso de dublagem em todo o show e artefatos corporais para simular sua aparência e voz de outrora numa cidade quase fantasma. Questionamos, então, como se dá a construção narrativa do espaço de pertencimento na música pop capaz de gerar nostalgia através dos conceitos de utopia e heterotopia (Foucault, a noção de “lar” (Boym.

  7. Organelle and cellular abnormalities associated with hippocampal heterotopia in neonatal doublecortin knockout mice.

    Directory of Open Access Journals (Sweden)

    Reham Khalaf-Nazzal

    Full Text Available Heterotopic or aberrantly positioned cortical neurons are associated with epilepsy and intellectual disability. Various mouse models exist with forms of heterotopia, but the composition and state of cells developing in heterotopic bands has been little studied. Dcx knockout (KO mice show hippocampal CA3 pyramidal cell lamination abnormalities, appearing from the age of E17.5, and mice suffer from spontaneous epilepsy. The Dcx KO CA3 region is organized in two distinct pyramidal cell layers, resembling a heterotopic situation, and exhibits hyperexcitability. Here, we characterized the abnormally organized cells in postnatal mouse brains. Electron microscopy confirmed that the Dcx KO CA3 layers at postnatal day (P 0 are distinct and separated by an intermediate layer devoid of neuronal somata. We found that organization and cytoplasm content of pyramidal neurons in each layer were altered compared to wild type (WT cells. Less regular nuclei and differences in mitochondria and Golgi apparatuses were identified. Each Dcx KO CA3 layer at P0 contained pyramidal neurons but also other closely apposed cells, displaying different morphologies. Quantitative PCR and immunodetections revealed increased numbers of oligodendrocyte precursor cells (OPCs and interneurons in close proximity to Dcx KO pyramidal cells. Immunohistochemistry experiments also showed that caspase-3 dependent cell death was increased in the CA1 and CA3 regions of Dcx KO hippocampi at P2. Thus, unsuspected ultrastructural abnormalities and cellular heterogeneity may lead to abnormal neuronal function and survival in this model, which together may contribute to the development of hyperexcitability.

  8. Diagnostic accuracy of nodular gastritis for H. pylori infection

    Directory of Open Access Journals (Sweden)

    Romero-Flores JL

    2016-12-01

    Full Text Available Juan L Romero-Flores,1 Justo A Fernandez-Rivero,1 Erika Marroquín-Fabian,1 Félix I Téllez-Ávila,2 Beatriz A Sánchez-Jiménez,1 Eva Juárez-Hernández,3 Misael Uribe,1 Norberto C Chávez-Tapia1,3 1Obesity and Digestive Diseases Unit, Medica Sur Clinic & Foundation, 2Department of Gastrointestinal Endoscopy, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 3Translational Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico Background: The term nodular is not included in the Sydney classification and there is no widely accepted histopathological definition. It has been proposed that the presence of antral nodularity could predict Helicobacter pylori (H. pylori infection. The aim of this study was to determine the diagnostic accuracy of nodular gastritis (NG for H. pylori infection after a rigorous standardization process, and to describe the associated histopathological characteristics. Materials and methods: Endoscopic images of patients submitted to endoscopy with biopsy sampling were included. Endoscopic images were distributed among six endoscopists. The analysis was performed sequentially in three rounds: the first round assessed the interobserver variability, the second evaluated the intraobserver variability, and the third calculated the interobserver variability after training. A correlation analysis between endoscopic and histopathological findings was performed. Results: A total of 917 studies were included. In the first analysis of interobserver variability, a poor kappa value (0.078 was obtained. The second evaluation yielded good intraobserver variability, with kappa values of 0.62–0.86. The evaluation of interobserver variability after training revealed an improvement in the kappa value of 0.42. A correlation was found between endoscopic images and histopathological reports. Conclusion: There was a strong correlation between NG and H. pylori, but only after rigorous evaluation. The use of

  9. Oral doxycycline, niacinamide and prednisolone used to treat bilateral nodular granulomatous conjunctivitis of the third eyelid in an Australian Kelpie dog.

    Science.gov (United States)

    Hurn, Simon; Mc Cowan, Christina; Turner, Andrew

    2005-01-01

    A 5-year-old, female neutered, Australian Kelpie presented with a 2-month history of dramatic bilateral erythematous thickening of the third eyelids. Ophthalmic examination demonstrated raised, pink to red, irregular thickening of the entire palpebral surface of both third eyelids. There were no other ocular abnormalities. A surgical biopsy was taken from each third eyelid. Histopathologic examination revealed sheets of macrophages, plasma cells, lymphocytes, and occasional fibroblasts and neutrophils infiltrating the third eyelid stroma. A diagnosis of chronic granulomatous conjunctivitis was made. Grossly and histopathologically this case closely resembles previously described cases of nodular granulomatous conjunctivitis involving the third eyelids of Collie dogs. This report describes an unusual case of nodular granulomatous conjunctivitis isolated to the third eyelids in an Australian Kelpie. Resolution of the condition was achieved with a combination of oral doxycycline, niacinamide and prednisolone.

  10. Proliferation and cell death in an experimental model of brain tissue heterotopia in the lung Proliferação e morte celular na heterotopia encefálica experimental

    Directory of Open Access Journals (Sweden)

    Paulo Roberto Veiga Quemelo

    2010-08-01

    Full Text Available PURPOSE: To investigate the proliferation and neuronal death in brain tissue heterotopia in the lung in an experimental model during both fetal and neonatal periods. METHODS: Twenty four pregnant female Swiss mice were used to induce brain tissue heterotopia on the 15th gestational day. Briefly, the brain of one fetus of each dam was extracted, disaggregated and injected into the right hemithorax of siblings. Six of these fetuses with pulmonary brain tissue implantation (PBI were collected on the 18th gestational day (group E18 and six other on the 8th postnatal day (group P8. Immunohistochemical staining for PCNA and Bcl2 were used to assess proliferation and cell death. RESULTS: PCNA Labelling Index (LI in heterotopic brain tissue was greater in fetal than postnatal period (E18 > P8 (pOBJETIVO: Investigar a proliferação e morte neuronal na heterotopia encefálica pulmonar em modelo experimental durante o período fetal e neonatal. MÉTODOS: Foram utilizados 24 camundongos Swiss fêmeas prenhes para induzir a heterotopia encefálica no pulmão. O tecido encefálico de um feto de cada fêmea prenha foi removido, picotado e injetado no pulmão dos irmãos. Seis fetos com Implantação Encefálica Pulmonar (IEP foram coletados no 18º dia gestacional (grupo E18 e seis outros fetos no 8º dia pós-natal (grupo P8. Foi realizada a reação Imuno-histoquímica para PCNA e Bcl2 para analisar a proliferação e morte celular. RESULTADOS: O índice de marcação (IM para PCNA era maior no período fetal quando comparado com o período pós-natal (E8 > P18 (p<0,05 e a imunomarcação para o anticorpo Bcl2 não apresentou diferença. CONCLUSÃO: A proliferação celular foi mantida no tecido heterotópico encefálico, embora a apoptose também foi observada.

  11. Factors Influencing MgO Content of RE-Mg Nodularizing Alloy%REMg球化剂中MgO含量的影响因素

    Institute of Scientific and Technical Information of China (English)

    杨宇鹏; 肖勇

    2013-01-01

    The effect of Mg in nodularizing alloy was introduced.When the total content of Mg was constant,the formation of MgO reduced the content of the effective Mg that would influence the nodularizing capability of the nodualrizing alloy.The source of MgO in nodularizing alloy was analyzed as follows:the MgO formed during the melting process of the nodularizing alloy and the MgO formed during the analysis sample preparing process.It was pointed out after analyzing two cases:(1) the MgO content of nodularizing alloy is the main factor influencing its nodularzing capability,therefore the MgO content should be reduced by improving its melting process; (2)In order to ensure the veracity of MgO content test it's necessary to use correct sample preparing method.%介绍了Mg在球化剂中的作用.当w(Mg总)一定时,MgO的生成降低了w(Mg有效)的含量,影响到球化剂的球化能力.分析了球化剂中MgO的来源:球化剂熔炼过程中产生MgO、在制取分析样品过程中产生MgO.通过2个案例的分析,指出:(1)球化剂中MgO含量的高低是影响其球化能力的主要因素,应通过改进熔炼工艺来降低w(MgO)量;(2)为确保球化剂中w(MgO)量检测的准确性,应采用正确的样品制备方法.

  12. Benign Hepatocellular Tumors in Children: Focal Nodular Hyperplasia and Hepatocellular Adenoma

    Directory of Open Access Journals (Sweden)

    Stéphanie Franchi-Abella

    2013-01-01

    Full Text Available Benign liver tumors are very rare in children. Most focal nodular hyperplasia (FNH remain sporadic, but predisposing factors exist, as follows: long-term cancer survivor (with an increasing incidence, portal deprivation in congenital or surgical portosystemic shunt. The aspect is atypical on imaging in two-thirds of cases. Biopsy of the tumor and the nontumoral liver is then required. Surgical resection will be discussed in the case of large tumors with or without symptoms. In the case of associated vascular disorder with portal deprivation, restoration of the portal flow will be discussed in the hope of seeing the involution of FNH. HepatoCellular Adenoma (HCA is frequently associated with predisposing factors such as GSD type I and III, Fanconi anemia especially if androgen therapy is administered, CPSS, and SPSS. Adenomatosis has been reported in germline mutation of HNF1-α. Management will depend on the presence of a predisposing factor and may include metabolic control, androgen therapy withdrawn, or closure of the shunt when appropriate. Surgery is usually performed on large lesions. In the case of adenomatosis or multiple lesions, surgery will be adapted. Close followup is required in all cases.

  13. Influence of iodization programmes on the epidemiology of nodular goitre.

    Science.gov (United States)

    Fiore, Emilio; Tonacchera, Massimo; Vitti, Paolo

    2014-08-01

    Iodine is essential for the synthesis of thyroid hormones. Iodine deficiency can affect human health in different ways, and is commonly referred to as iodine deficiency disorders (IDD). These range from defective development of the central nervous system during the fetal-neonatal life, to goitre in the adult. Only a few countries were completely iodine sufficient before 1990. Since then, a major effort has been made to introduce salt iodization to ensure sufficient intake of iodine in deficient areas. Iodine prophylaxis has been shown to exert a pivotal role in abating goitre and other iodine-deficiency disorders, and has also been shown to modulate the pattern of thyroid diseases. An increased frequency of thyroid autoimmunity and of hypothyroidism has been observed after introducing iodization programmes. Nevertheless, available evidence clearly confirms that the benefits of correcting iodine deficiency, consisting mainly of reducing nodular goitre and non-autoimmune hyperthyroidism, far outweigh the risks of iodine supplementation.

  14. The role of radioiodine therapy in benign nodular goitre

    DEFF Research Database (Denmark)

    Bonnema, Steen Joop; Fast, Søren; Hegedüs, Laszlo

    2014-01-01

    For treatment of benign nodular goitre the choice usually stands between surgery and (131)I therapy. (131)I therapy, used for 30 years for this condition, leads to a goitre volume reduction of 35-50% within 1-2 years. However, this treatment has limited efficacy if the thyroid (131)I uptake is low...... or if the goitre is large. Recombinant human TSH (rhTSH)-stimulated (131)I therapy significantly improves goitre reduction, as compared with conventional (131)I therapy without pre-stimulation, and adverse effects are few with rhTSH doses of 0.1 mg or lower. RhTSH-stimulated (131)I therapy reduces the need...... for additional therapy due to insufficient goitre reduction, but the price is a higher rate of hypothyroidism. Another approach with rhTSH-stimulation is to reduce the administered (131)I activity by a factor that equals the increase in the thyroid (131)I uptake. Using this approach, radiation exposure...

  15. Nodular lymphocyte predominant hodgkin lymphoma: biology, diagnosis and treatment.

    Science.gov (United States)

    Goel, Anupama; Fan, Wen; Patel, Amit A; Devabhaktuni, Madhuri; Grossbard, Michael L

    2014-08-01

    Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is an uncommon variant of classical Hodgkin lymphoma. It is characterized histologically by presence of lymphohistiocytic cells which have B-cell phenotype, are positive for CD19, CD20, CD45, CD79a, BOB.1, Oct.2, and negative for CD15 and CD30. Patients often present with early stage of disease and do not have classical B symptoms. The clinical behavior appears to mimic that of an indolent non-Hodgkin lymphoma more than that of classical Hodgkin disease. The purpose of the present report is to define the biology of NLPHL, review its clinical presentation, and summarize the available clinical data regarding treatment.

  16. Esclerite nodular e poliangiite granulomatosa (Wegener mimetizando tuberculose

    Directory of Open Access Journals (Sweden)

    Cybelle Moreno Luize Franco

    2015-04-01

    Full Text Available Poliangiite granulomatosa é uma doença sistêmica que afeta qualquer órgão, com predileção pelo trato respiratório superior, pulmões e rins. Este artigo tem como objetivo relatar um caso atípico de uma paciente com esclerite nodular como manifestação inicial da poliangiite granulomatosa (Wegener, mimetizando um quadro de tuberculose. A paciente apresentou hiperemia ocular e baixa acuidade visual progressiva por 1,5 anos, seguido por dor ocular por dois meses. A paciente possuía nódulos subpleurais com densidade de partes moles, linfonodomegalia em janela aorto-pulmonar e espessamento pleural bilateral discreto, negativo para bacilos álcool-ácido resistentes (BAAR. O diagnóstico histológico revelou uma vasculite granulomatosa sugestiva de vasculite não infecciosa (poliangiite granulomatosa. Foi iniciada pulsoterapia com ciclofosfamida.

  17. Focal nodular hyperplasia of the liver in longterm survivors of neuroblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Benz-Bohm, Gabriele, E-mail: g.benz-bohm@t-online.d [Division of Pediatric Radiology, A. Gossmann (formerly), Department of Radiology, University of Cologne, Kerpenerstr. 62, 50924 Koeln (Germany); Hero, Barbara, E-mail: barbara.hero@uk-koeln.d [Department of Pediatrics, Division of Pediatric Oncology and Hematology, University of Cologne, Kerpenerstr. 62, 50924 Koeln (Germany); Gossmann, Axel, E-mail: GossmannA@kliniken-koeln.d [Department of Radiology, Cologne City Hospitals, Ostmerheimer Strasse 200, 51109 Koeln (Germany); Simon, Thorsten, E-mail: thorsten.simon@uk-koeln.d [Department of Pediatrics, Division of Pediatric Oncology and Hematology, University of Cologne, Kerpenerstr. 62, 50924 Koeln (Germany); Koerber, Friederike, E-mail: friederike.koerber@uk-koeln.d [Division of Pediatric Radiology, A. Gossmann (formerly), Department of Radiology, University of Cologne, Kerpenerstr. 62, 50924 Koeln (Germany); Berthold, Frank, E-mail: frank.berthold@uk-koeln.d [Department of Pediatrics, Division of Pediatric Oncology and Hematology, University of Cologne, Kerpenerstr. 62, 50924 Koeln (Germany)

    2010-06-15

    Objectives: Focal nodular hyperplasia of the liver is a tumor-like lesion, uncommon in children, but it has recently been more frequently observed in children treated for malignant diseases, especially neuroblastoma. The aetiology is unclear, the pathogenesis remains controversial. Focal nodular hyperplasia of the liver is suspected to be a sequela of tumor therapy. Methods: Besides the clinical data we evaluated the imaging modalities needed to diagnose focal nodular hyperplasia of the liver in children with neuroblastoma who have been followed in our institution for more than 5 years. Results: Out of 60 children six developed focal nodular hyperplasia at a median time of 10.5 years after diagnosis of neuroblastoma and 9.4 years after the end of treatment. The diagnosis of focal nodular hyperplasia was based on imaging criteria which are variable in ultrasonography and specific in MRI. Only one child underwent surgical biopsies to rule out liver metastases. Conclusions: Longterm survivors of neuroblastoma are at risk of developing focal nodular hyperplasia, especially if they underwent toxic chemotherapy and/or radiotherapy to the liver during initial treatment. The recommended diagnostic imaging tools are ultrasonography for detecting liver lesions and MRI for confirming and characterizing these lesions as focal nodular hyperplasia.

  18. [Histopathological Study of the Relationship between Lymphoid Follicles and Different Endoscopic Types of Nodular Gastritis].

    Science.gov (United States)

    Nagata, Takuo; Ishitake, Hisahito; Shimamoto, Fumio; Tamura, Tadamasa; Matsumura, Kazunori; Sumii, Masaharu; Nakai, Shirou

    2014-11-01

    Nodular gastritis is characterized histologically by hyperplasia and enlargement of lymphoid follicles in the lamina propria. With the objective of elucidating the relationship between different endoscopic types of nodular gastritis and lymphoid follicles, distributions of lymphoid follicles in the lamina propria were investigated in young gastric cancer patients with nodular gastritis. For the study, whole-mucosal step sectioning of each resected stomach was performed, the densities of lymphoid follicles of all specimens were measured microscopically, and the horizontal and depth distributions were calculated. For assessment in the horizontal direction, density distribution diagrams of lymphoid follicles were created. For assessment in the depth direction, the different endoscopic types of nodular gastritis were compared in the five different analysis sites. In the assessment of the horizontal distribution, no characteristic distribution tendencies were observed in either the granular type group or the scattered type group; however, it was found that areas with relatively high densities of lymphoid follicles generally coincided with the areas where nodular gastritis was observed endoscopically. These results suggested that hyperplasia and aggregation of lymphoid follicles in the lamina propria are involved at the sites where nodular gastritis is observed endoscopically. In the assessment of the depth distribution, lymphoid follicles tended to be more unevenly distributed in the upper lamina propria in the granular type group than in the scattered type at the three different analysis sites where nodular gastritis was observed endoscopically. These results suggested the possibility of a granular type characteristic.

  19. Thyroid Hormone-Dependent Formation of a Subcortical Band Heterotopia (SBH) in the Neonatal Brain is not Exacerbated Under Conditions of Low Dietary Iron

    Science.gov (United States)

    Thyroid hormones (TH) are critical for brain development. Modest TH insufficiency in pregnant rats induced by propylthiouracil (PTU) results in formation of a structural abnormality, a subcortical band heterotopia (SBH), in brains of offspring. PTU reduces TH by inhibiting the s...

  20. Regeneration of 5-HT fibers in hippocampal heterotopia of methylazoxymethanol-induced micrencephalic rats after neonatal 5,7-DHT injection.

    Science.gov (United States)

    Nakamura, Arata; Kadowaki, Taro; Sakakibara, Shin-ichi; Yoshimoto, Kanji; Hirata, Koichi; Ueda, Shuichi

    2010-03-01

    In order to elucidate the regeneration properties of serotonergic fibers in the hippocampus of methylazoxymethanol acetate (MAM)-induced micrencephalic rats (MAM rats), we examined serotonergic regeneration in the hippocampus following neonatal intracisternal 5,7-dihydroxytryptamine (5,7-DHT) injection. Prenatal exposure to MAM resulted in the formation of hippocampal heterotopia in the dorsal hippocampus. Immunohistochemical and neurochemical analyses revealed hyperinnervation of serotonergic fibers in the hippocampus of MAM rats. After neonatal 5,7-DHT injection, most serotonergic fibers in the hippocampus of 2-week-old MAM rats had degenerated, while a small number of serotonergic fibers in the stratum lacunosum-moleculare (SLM) of the hippocampus and in the hilus adjacent to the granular cell layer of the dentate gyrus (DG) had not. Regenerating serotonergic fibers from the SLM first extended terminals into the hippocampal heterotopia, then fibers from the hilus reinnervated the DG and some fibers extended to the heterotopia. These findings suggest that the hippocampal heterotopia exerts trophic target effects for regenerating serotonergic fibers in the developmental period in micrencephalic rats.

  1. Thyroid Hormone-Dependent Formation of a Subcortical Band Heterotopia (SBH) in the Neonatal Brain is not Exacerbated Under Conditions of Low Dietary Iron

    Science.gov (United States)

    Thyroid hormones (TH) are critical for brain development. Modest TH insufficiency in pregnant rats induced by propylthiouracil (PTU) results in formation of a structural abnormality, a subcortical band heterotopia (SBH), in brains of offspring. PTU reduces TH by inhibiting the s...

  2. Feasibility and practice of nodular iron casting feeder-less production

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The volumetric changes of castings and dimension changes of mould cavity occurring during liquid cooling and solidification of nodular iron castings were described. The feasibility and prerequisites to realize feeder-less production of nodular iron castings was analyzed and proved with practical examples. It was pointed out that the feeder-less foundry method is by no means a feeding-less method, and it was emphasized that adopting high carbon equivalent, high rigidity mould, simultaneous and synchronous solidification, and intensifying cooling capacity of the mould to increase feeding effect of the gating system are important to successfully realize feeder-less production of nodular iron castings.

  3. Effect of the Carbides and Matrix on the Wear Resistance of Nodular Cast Iron

    Directory of Open Access Journals (Sweden)

    G. Gumienny

    2013-07-01

    Full Text Available This paper presents the results of the abrasive wear resistance of selected types of nodular cast iron, including ADI, cooperating with quartz sand and 100 grit abrasive paper. It has been shown that carbides in nodular cast iron cause an increase in wear resistance of 6 to 12% depending on the surface fraction of the carbides and type of the matrix. For the same unit pressure the mass loss of the cast iron cooperating with quartz sand is many times larger than the cast iron cooperating with abrasive paper. For both abrasives the highest wear resistance showed nodular cast iron with upper and lower bainite and carbides.

  4. Effect of the Carbides and Matrix on the Wear Resistance of Nodular Cast Iron

    Directory of Open Access Journals (Sweden)

    Gumienny G.

    2013-09-01

    Full Text Available This paper presents the results of the abrasive wear resistance of selected types of nodular cast iron, including ADI, cooperating with quartz sand and 100 grit abrasive paper. It has been shown that carbides in nodular cast iron cause an increase in wear resistance of 6 to 12% depending on the surface fraction of the carbides and type of the matrix. For the same unit pressure the mass loss of the cast iron cooperating with quartz sand is many times larger than the cast iron cooperating with abrasive paper. For both abrasives the highest wear resistance showed nodular cast iron with upper and lower bainite and carbides.

  5. Feasibility and practice of nodular iron casting feeder-less production

    Directory of Open Access Journals (Sweden)

    ZHOU Gen

    2006-02-01

    Full Text Available The volumetric changes of castings and dimension changes of mould cavity occurring during liquid cooling and solidification of nodular iron castings were described. The feasibility and prerequisites to realize feeder-less production of nodular iron castings was analyzed and proved with practical examples. It was pointed out that the feeder-less foundry method is by no means a feeding-less method, and it was emphasized that adopting high carbon equivalent, high rigidity mould, simultaneous and synchronous solidification, and intensifying cooling capacity of the mould to increase feeding effect of the gating system are important to successfully realize feeder-less production of nodular iron castings.

  6. Fascitis nodular en región facial en edades pediátricas Nodular fasciitis present in facial area in children

    Directory of Open Access Journals (Sweden)

    Dadonim Vila Morales

    2009-09-01

    Full Text Available Propósito: Presentar 3 casos de fascitisnodular de región facial. Método: Se realizó un estudio de los pacientes que comprendió examen físico, análisis de laboratorio y radiológico. Se describió la conducta quirúrgica o médica realizada en cada caso y su diagnóstico anatomopatológico. Resultados: Se mostró el método científico como única vía de llegar al diagnóstico certero, a pesar de enfrentar el reto de diagnosticar una entidad nosológica inusual en la cirugía maxilofacial. Se discutió la evolución de cada paciente y la literatura consultada. Conclusiones: Resulta muy útil la presentación de estos casos, pues esta tumoración presenta una localización muy poco frecuente en cara y su rápido crecimiento y evolución clínica son habitualmente difíciles de interpretar.Aim: To present 3 cases of nodular fasciitis in facial area. Method: A study was carried out in patients including physical examination, laboratory and radiologic analysis. Surgical or medical behavior was described present in each case with an anatomical and the pathological diagnosis was made. Results: Scientific method was the only route to achieve an accurate diagnosis despite the challenge of diagnosing an uncommon disease entity in maxillofacial surgery. In each patient the course was discussed as well as a literature review. Conclusions: The presentation of these cases is very essential since this tumor has a not much location in the face and its fast developmental and clinical course are often difficult to interpret.

  7. Characterization of the Pathological and Biochemical Markers that Correlate to the Clinical Features of Autism. Subproject 1: The Neuropathological Markers of Abnormal Brain Development and Aging in Autism

    Science.gov (United States)

    2013-04-01

    heterotopias and dysplastic changes in the hippocampus in 89% of dup 15 cases (10% in idiopathic autism). Cerebral cortical dysplasia was found only in...subependymal nodular dysplasia, hypothalamus, serotonergic system, desynchronized neuronal growth, clinico -pathological correlations 16. SECURITY... Cases with signs of comorbidity, premortem and postmortem changes affecting brain structure were excluded from the morphometric studies. 3. To

  8. Normotopic and heterotopic cortical representations of mystacial vibrissae in rats with subcortical band heterotopia.

    Science.gov (United States)

    Schottler, F; Fabiato, H; Leland, J M; Chang, L Y; Lotfi, P; Getachew, F; Lee, K S

    2001-01-01

    The tish rat is a neurological mutant exhibiting bilateral cortical heterotopia similar to those found in certain epileptic patients. Previous work has shown that thalamocortical fibers originating in the ventroposteromedial nucleus, which in normal animals segregate as 'barrel' representations for individual whiskers, terminate in both normotopic and heterotopic areas of the tish cortex (Schottler et al., 1998). Thalamocortical innervation terminates as barrels in layer IV and diffusely in layer VI of the normotopic area. Discrete patches of terminals are also observed in the underlying heterotopic area suggesting that representations of individual vibrissa may be present in the heterotopic somatosensory areas. The present study examines this issue by investigating the organization of the vibrissal somatosensory system in the tish cortex. Staining for cytochrome oxidase or Nissl substance reveals a normal complement of vibrissal barrels in the normotopic area of the tish cortex. Dense patches of cytochrome oxidase staining are also found in the underlying lateral portions of the heterotopic area (i.e. the same area that is innervated by the ventroposteromedial nucleus). Injections of retrograde tracers into vibrissal areas of either the normotopic or heterotopic area produce topographically organized labeling of neurons restricted to one or a small number of barreloids within the ventroposteromedial nucleus of the thalamus. Physical stimulation of a single whisker (D3 or E3) elicits enhanced uptake of [(14)C]2-deoxyglucose in restricted zones of both the normotopic and heterotopic areas, demonstrating that single whisker stimulation can increase functional activity in both normotopic and heterotopic neurons. These findings indicate that the barrels are intact in the normotopic area and are most consistent with the hypothesis that at least some of the individual vibrissae are 'dually' represented in normotopic and heterotopic positions in the primary somatosensory

  9. Duodenal Bulb Mucosa with Hypertrophic Gastric Oxyntic Heterotopia in Patients with Zollinger Ellison Syndrome

    Directory of Open Access Journals (Sweden)

    Emil Kohan

    2009-01-01

    Full Text Available Objectives. Zollinger-Ellison Syndrome (ZES results in hypersecretion of gastric acid (via gastrinoma leading to peptic ulcers, diarrhea, and abdominal pain. We describe the novel discovery of hypertrophic, heterotopic gastric mucosa in the proximal duodenal bulb in patients with ZES, which we hypothesize results in an increased incidence of postbulbar ulcers in patients with ZES (a mechanism previously unreported. We determined the incidence of the novel finding of duodenal gastric oxyntic hypertrophic heterotopia (GOH in patients with ZES. Methods. Seven patients with ZES were enrolled. The diagnosis of ZES was established by hypergastrinemia, gastric acid hypersecretion, and a positive secretin test or based on biopsy specimens (evaluated via tissue staining. Basal acid output (BAO and baseline gastrin secretion were determined by established methods. Endoscopic examinations with methylene blue staining and biopsy of the gastric and duodenal mucosa were conducted in all patients every 3–6 months for an average of 5 years. Results. The duodenal mucosa demonstrated hypertrophic GOH in 5 out of 7 patients with ZES and an intact stomach and duodenum. Biopsies from the bowel mucosa demonstrated patchy replacement of surface epithelium by gastric-type epithelium with hypertrophic oxyntic glands in the lamina propria in 5 patients. Two of the patients had no evidence of GOH in the duodenal bulb. Patients with GOH had an average serum gastrin level of 1245 pg/mL and BAO of 2.92 mEq/hr versus 724 pg/mL and 0.8 mEq/hr in patients without GOH. Conclusions. This study demonstrated the presence of duodenal mucosa with GOH in 5 out of 7 patients with ZES and an intact stomach and duodenum. The presence of hypertrophic and heterotopic gastric mucosa is proposed to result from increased gastrin levels and may contribute to the increased incidence of postbulbar ulcers in these patients.

  10. Nodular lymphoid hyperplasia: A marker of low-grade inflammation in irritable bowel syndrome?

    Science.gov (United States)

    Piscaglia, Anna Chiara; Laterza, Lucrezia; Cesario, Valentina; Gerardi, Viviana; Landi, Rosario; Lopetuso, Loris Riccardo; Calò, Giovanni; Fabbretti, Giovanna; Brisigotti, Massimo; Stefanelli, Maria Loredana; Gasbarrini, Antonio

    2016-12-14

    To evaluate the prevalence of nodular lymphoid hyperplasia (NLH) in adult patients undergoing colonoscopy and its association with known diseases. We selected all cases showing NLH at colonoscopy in a three-year timeframe, and stratified them into symptomatic patients with irritable bowel syndrome (IBS)-type symptoms or suspected inflammatory bowel disease (IBD), and asymptomatic individuals undergoing endoscopy for colorectal cancer screening. Data collection included medical history and final diagnosis. As controls, we considered all colonoscopies performed for the aforementioned indications during the same period. One thousand and one hundred fifty colonoscopies were selected. NLH was rare in asymptomatic individuals (only 3%), while it was significantly more prevalent in symptomatic cases (32%). Among organic conditions associated with NLH, the most frequent was IBD, followed by infections and diverticular disease. Interestingly, 31% of IBS patients presented diffuse colonic NLH. NLH cases shared some distinctive clinical features among IBS patients: they were younger, more often female, and had a higher frequency of abdominal pain, bloating, diarrhoea, unspecific inflammation, self-reported lactose intolerance and metal contact dermatitis. About 1/3 of patients with IBS-type symptoms or suspected IBD presented diffuse colonic NLH, which could be a marker of low-grade inflammation in a conspicuous subset of IBS patients.

  11. Treatment with adalimumab in a patient with regenerative nodular hyperplasia secondary to azathioprine

    Directory of Open Access Journals (Sweden)

    Rafael León-Montañes

    2013-03-01

    Full Text Available Introduction: regenerative nodular hyperplasia (RNH is a rare liver disease with an etiology that is not well understood. Among the etiological factors are purine-analogue drugs such as azathioprine. Case report: we present a case of a 47-year-old patient diagnosed with Crohn's disease in treatment with azathioprine due to corticosteroid dependency who developed RNH with clinical and laboratory signs of portal hypertension one year after starting treatment. After discontinuation of azathioprine, the patient started treatment and, given the poor disease progression, started treatment with adalimumab. This was continued with an excellent response and without deleterious effects on the liver. Discussion: the relevance of this case is twofold: First, this is a rare and early side effect of azathioprine treatment and this is an irreversible disease with potentially serious complications. Second, because treatment was carried out with biological drugs (adalimumab despite the patient having advance liver disease with portal hypertension without any evidence of its worsening, nor signs of deleterious effects or complications, given that there is scarce or no experience with adalimumab treatment in this type of situation.

  12. Nodular lymphoid hyperplasia: A marker of low-grade inflammation in irritable bowel syndrome?

    Science.gov (United States)

    Piscaglia, Anna Chiara; Laterza, Lucrezia; Cesario, Valentina; Gerardi, Viviana; Landi, Rosario; Lopetuso, Loris Riccardo; Calò, Giovanni; Fabbretti, Giovanna; Brisigotti, Massimo; Stefanelli, Maria Loredana; Gasbarrini, Antonio

    2016-01-01

    AIM To evaluate the prevalence of nodular lymphoid hyperplasia (NLH) in adult patients undergoing colonoscopy and its association with known diseases. METHODS We selected all cases showing NLH at colonoscopy in a three-year timeframe, and stratified them into symptomatic patients with irritable bowel syndrome (IBS)-type symptoms or suspected inflammatory bowel disease (IBD), and asymptomatic individuals undergoing endoscopy for colorectal cancer screening. Data collection included medical history and final diagnosis. As controls, we considered all colonoscopies performed for the aforementioned indications during the same period. RESULTS One thousand and one hundred fifty colonoscopies were selected. NLH was rare in asymptomatic individuals (only 3%), while it was significantly more prevalent in symptomatic cases (32%). Among organic conditions associated with NLH, the most frequent was IBD, followed by infections and diverticular disease. Interestingly, 31% of IBS patients presented diffuse colonic NLH. NLH cases shared some distinctive clinical features among IBS patients: they were younger, more often female, and had a higher frequency of abdominal pain, bloating, diarrhoea, unspecific inflammation, self-reported lactose intolerance and metal contact dermatitis. CONCLUSION About 1/3 of patients with IBS-type symptoms or suspected IBD presented diffuse colonic NLH, which could be a marker of low-grade inflammation in a conspicuous subset of IBS patients. PMID:28028368

  13. Reduced densities of parvalbumin- and somatostatin-expressing interneurons in experimental cortical dysplasia and heterotopia in early postnatal development.

    Science.gov (United States)

    Akakin, Dilek; Martinez-Diaz, Hildabelis; Chen, Huan-Xin; Roper, Steven N

    2013-05-01

    Cortical dysplasia (CD) is strongly associated with intractable epilepsy, probably due to hyperexcitability of neuronal networks. However, the underlying mechanisms are not completely understood. GABAergic interneurons provide major inhibitory function in the CNS and have different subtypes, but it is not clear how each subtype is affected in CD during early post-natal development. We have examined the developmental alterations of the densities of two major subtypes of interneurons, parvalbumin (PV)- and somatostatin (SS)-expressing interneurons in an animal model of CD, in utero irradiation, using immunocytochemistry. We found that the density of PV- and SS-positive interneurons increases significantly in CD and controls during the first three weeks of postnatal life. However, compared to controls, the densities of both subtypes are significantly decreased in CD and heterotopia at all age groups although the time of onset for both PV and SS expression remained unchanged. Our results indicate that the densities of both PV- and SS-positive interneurons are significantly decreased in CD and heterotopia, which may be one important mechanism leading to hyperexcitability of CD.

  14. Band heterotopia: case report%带状灰质异位1例

    Institute of Scientific and Technical Information of China (English)

    张泉; 冯凯琳; 袁飞; 董少义

    2008-01-01

    患者女,19岁。主诉反复癫痫发作6年余入院。患者于6年前突发四肢抽搐,不伴有意识丧失,初次发病后间断发作,每次间隔约1年左右,自服抗癫痫药物治疗无效,近半年发作频繁。患者智力尚可,初中文化程度。脑电图检查显示:广泛性轻度异常波形。

  15. Super selective transcatheter arterial embolization for treatment of focal nodular hyperplasia of the liver: report of 21 cases%超选择性肝动脉栓塞术治疗肝脏局灶性结节增生研究

    Institute of Scientific and Technical Information of China (English)

    阎洁羽; 王茂强; 刘凤永; 王志军; 段峰; 宋鹏

    2012-01-01

    目的 评价经导管超选择性肝动脉栓塞术(TAE)治疗肝脏局灶性结节增生(FNH)的安全性和疗效.方法 2005年1月至2010年12月间解放军总医院介入放射科收治21例FNH患者,男16例、女5例,年龄16 ~ 44(28±12)岁.全部病例均经病理检查证实为FNH.治疗指征为病灶有增长趋势、有压迫等相关症状、不宜实施外科切除者,或有外科治疗指征、但患者拒绝接受外科治疗者.超选择性栓塞材料为碘油-博来霉素乳剂和聚乙烯醇微球(PVA).术后随访内容有血常规、肝肾功能、超声波、CT和(或)MRI.结果 单发病灶18例:14例(66.7%)位于肝右叶、4例位于左叶(19.0%),左、右叶多发病灶3例(14.3%);肿块最大直径3.5~9.5(5.5±3.0) cm.血管造影均显示为界限清楚的富血管性结节,无动静脉瘘和门静脉侵犯表现.21例均做1次TAE,技术成功率为100%,无重要并发症.术后随访1~6(3.5±2.0)年,病灶明显缩小并完全被碘油充盈、无动脉血供16例,病灶接近消失5例,无复发病例.结论 超选择性肝动脉栓塞术是治疗FNH的安全有效方法,可获得控制病灶增长、甚至根治效果.%Objective To evaluate the efficiency and safety of transcatheter arterial embolization (TAE) for treatment of focal nodular hyperplasia (FNH).Methods From January 2005 to December 2010,super selective TAE was performed for 21 patients with FNH.The patients consisted of 16 men and 5 women with age range of 16 to 44 years (mean age,28 ± 12).Liver contrast enhancement CT and ultrasonography (US) were performed in all patients,dynamic contrast enhancement MRI was performed in 17 patients.All patients underwent percutaneous needle biopsies and the diagnosis of FNH was proven histologically.The indications for TAE were patients with progressive increase in size of FNH,who were not candidates for surgical treatment,or who refused for surgery.Embolic materials used in this series included emulsion of

  16. Nodular sclerosis classical Hodgkin lymphoma grade 2: A diagnostic challenge to the cytopathologists.

    Science.gov (United States)

    Sharma, Sudha; Dey, Pranab; Mitra, Suvradeep; Rajwanshi, Arvind; Nijhawan, Raje; Srinivasan, Radhika; Gupta, Nalini; Das, Ashim

    2017-02-01

    Grade 2 nodular sclerosis classical Hodgkin lymphoma (NSCHL) is less common than grade 1 lymphoma and has a worse overall prognosis. To the best of the authors' knowledge, no study of a large series of cases has been performed until now. The objective of this study was to assess the diagnostic efficacy of cytology for grade 2 NSCHL versus grade 1 NSCHL and study the morphological features of grade 2 NSCHL in fine-needle aspiration cytology (FNAC). Fifteen of 51 histopathology-proven cases of NSCHL (18 FNAC procedures) were grade 2, and 36 were grade 1. The efficacy of FNAC for detecting grade 1 and 2 NSCHL was assessed, and the frequency of misdiagnosis was compared. The clinical details and cytomorphological features of grade 2 NSCHL were studied in detail. Among the grade 1 NSCHL patients, 58.4% were diagnosed with Hodgkin lymphoma (HL) or had findings suggestive of HL, whereas 20% of the grade 2 patients were diagnosed HL or suggestive of HL. Two cases of grade 2 NSCHL were misdiagnosed as anaplastic large cell lymphoma, and 4 were misdiagnosed as malignant neoplasms. Grade 2 NSCHL cases showed clusters and sheets of mononuclear, multinucleated, and bizarre cells, with some cases showing a suppurative background. However, extensive searching showed occasional Reed-Sternberg (RS) cells in most of the cases, and lacunar cells were seen in 12 cases. The diagnostic efficacy of FNAC is much lower for grade 2 NSCHL versus grade 1 NSCHL. The search for an occasional RS cell and the identification of lacunar cells can provide a clue for the diagnosis. Cancer Cytopathol 2017;125:104-113. © 2016 American Cancer Society. © 2016 American Cancer Society.

  17. Focal nodular hyperplasia: typical and atypical MRI findings with emphasis on the use of contrast media

    Energy Technology Data Exchange (ETDEWEB)

    Marin, D. [Department of Radiological Sciences, University of Rome ' La Sapienza' , Rome (Italy)], E-mail: danielemarin2@gmail.com; Brancatelli, G. [Sezione di Radiologia, Ospedale Specializzato in Gastroenterologia, ' Saverio de Bellis' - IRCCS, Castellana Grotte (Bari) (Italy); Istituto di Scienze Radiologiche, Universita di Palermo, Palermo (Italy); Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA (United States); Federle, M.P. [Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA (United States); Lagalla, R. [Istituto di Scienze Radiologiche, Universita di Palermo, Palermo (Italy); Catalano, C.; Passariello, R. [Department of Radiological Sciences, University of Rome ' La Sapienza' , Rome (Italy); Midiri, M. [Istituto di Scienze Radiologiche, Universita di Palermo, Palermo (Italy); Vilgrain, V. [Service de Radiologie, Hopital Beaujon, Clichy (France)

    2008-05-15

    Focal nodular hyperplasia is a benign hypervascular hepatic tumour, frequently detected in asymptomatic patients undergoing imaging studies for unrelated reasons. Magnetic resonance imaging (MRI) generally allows a confident differential diagnosis with other hypervascular liver lesions, either benign or malignant. In addition, due to the recent development of hepatospecific MRI contrast agents, MRI concomitantly enables functional and morphological information to be obtained, thus providing important clues for the detection and characterization of focal nodular hyperplasia lesions.

  18. Henoch-Schonlein purpura presenting sequentially as nodular rash, erythema nodosum, and palpable purpura

    Directory of Open Access Journals (Sweden)

    Kandan Balamurugesan

    2014-01-01

    Full Text Available We describe a 26-year-old woman who presented with a nodular rash on the elbows following an insect bite. Two days later, she developed erythema nodosum. Both these lesions were treated symptomatically. One week later, she had purpura, abdominal pain, hematuria, and arthralgias, following which steroids were administered. Her investigations revealed only microscopic hematuria that disappeared with therapy. This pattern of sequential appearance of rash and a nodular morphology are both unique features not previously reported.

  19. Henoch–Schonlein purpura presenting sequentially as nodular rash, erythema nodosum, and palpable purpura

    Science.gov (United States)

    Balamurugesan, Kandan; Viswanathan, Stalin

    2014-01-01

    We describe a 26-year-old woman who presented with a nodular rash on the elbows following an insect bite. Two days later, she developed erythema nodosum. Both these lesions were treated symptomatically. One week later, she had purpura, abdominal pain, hematuria, and arthralgias, following which steroids were administered. Her investigations revealed only microscopic hematuria that disappeared with therapy. This pattern of sequential appearance of rash and a nodular morphology are both unique features not previously reported. PMID:24696039

  20. [AGE FEATURES OF PREVALENCE, LOCALISATION AND CLINICAL COURSE OF SOME NODULAR-ULCER FORMS OF BASAL CELL SKIN CANCER OF FACE AND HEAD].

    Science.gov (United States)

    Balakhonov, S I; Iordanishvili, A K

    2015-01-01

    During carrying out clinical trial on the base of Leningrad regional clinical hospital the incidence of basal cell skin cancer of the face and scalp has been studied in adults of different age groups, as well as peculiarities of clinical course of this disease in elderly and senile age. The most commonly encountered clinical form of basal cell cancer of the face and scalp in the Leningrad region was nodular-ulcerative, which was diagnosed in clinical practice in 38.3% of cases. The features of clinical course of superficial, nodular and destruida forms in people of middle, elderly and senile age are given. It is shown that the highest frequency of occurence of these clinical forms were in age of 61-70 years.

  1. The role of radioiodine therapy in benign nodular goitre.

    Science.gov (United States)

    Bonnema, Steen Joop; Fast, Søren; Hegedüs, Laszlo

    2014-08-01

    For treatment of benign nodular goitre the choice usually stands between surgery and (131)I therapy. (131)I therapy, used for 30 years for this condition, leads to a goitre volume reduction of 35-50% within 1-2 years. However, this treatment has limited efficacy if the thyroid (131)I uptake is low or if the goitre is large. Recombinant human TSH (rhTSH)-stimulated (131)I therapy significantly improves goitre reduction, as compared with conventional (131)I therapy without pre-stimulation, and adverse effects are few with rhTSH doses of 0.1 mg or lower. RhTSH-stimulated (131)I therapy reduces the need for additional therapy due to insufficient goitre reduction, but the price is a higher rate of hypothyroidism. Another approach with rhTSH-stimulation is to reduce the administered (131)I activity by a factor that equals the increase in the thyroid (131)I uptake. Using this approach, radiation exposure is considerably reduced while the goitre reduction is similar to that obtained with conventional (131)I therapy.

  2. Creep testing of nodular iron at ambient and elevated temperatures

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    Martinsson, Aasa; Andersson-Oestling, Henrik C.M.; Seitisleam, Facredin; Wu, Rui; Sandstroem, Rolf (Swerea KIMAB AB, Stockholm (Sweden))

    2010-12-15

    The creep strain at room temperature, 100 and 125 deg C has been investigated for the ferritic nodular cast iron insert intended for use as the load-bearing part of canisters for long term disposal of spent nuclear fuel. The microstructure consisted of ferrite, graphite nodules of different sizes, compacted graphite and pearlite. Creep tests have been performed for up to 41,000 h. The specimens were cut out from material taken from two genuine inserts, I30 and I55. After creep testing, the specimens from the 100 deg C tests were hardness tested and a metallographic examination was performed. Creep strains at all temperatures appear to be logarithmic, and accumulation of creep strain diminishes with time. The time dependence of the creep strain is consistent to the W-model for primary creep. During the loading plastic strains up to 1% appeared. The maximum recorded creep strain after the loading phase was 0.025%. This makes the creep strains technically insignificant. Acoustic emission recordings during the loading of the room temperature tests showed no sounds or other evidence of microcracking during the loading phase. There is no evidence that the hardness or the graphite microstructure changed during the creep tests

  3. Pathogenesis of nodular goiter and its implications for surgical management

    Energy Technology Data Exchange (ETDEWEB)

    Teuscher, J.; Peter, H.J.; Gerber, H.; Berchtold, R.; Studer, H.

    1988-01-01

    Despite sufficient iodine supply, goiter continues to be of considerable surgical significance in formerly endemic countries. It now appears that iodine deficiency and increased thyrotropin stimulation are not the only causes of goiter. Xenotransplantation of human thyroid tissue onto nude mice allowed study of the regulation of growth and function in human goiter tissue. Grafts of human thyroid tissue growing in nude mice could be shown to react to endogenous mouse thyrotropic stimulation and suppression. /sup 131/I autoradiographs of xenotransplanted goiter tissue showed as marked a heterogeneity as did the original goitrous tissue prior to transplantation. There was no firm correlation between the morphologic appearance of a follicle and its iodine metabolism. Scintigraphically cold and hot goiter tissue differed from each other quantitatively but not qualitatively; i.e., both hot and cold tissue were composed of metabolically active and nonactive follicles. Iodine organification was not completely suppressible by thyroxine treatment; this indicates autonomous functional activity. The distribution of proliferating tissue labeled by /sup 3/H-thymidine did not parallel the distribution of functionally active tissue labelled by /sup 131/I. Thyroxine treatment did not completely inhibit /sup 3/H-thymidine incorporation, indicating autonomous growth. Thus, our pathogenetic concept of goiter formation is based on three mainstays: (1) goiter heterogeneity, (2) autonomy of growth and function, and (3) dissociation of growth and function in human goiter tissue. Thus, the surgeon dealing with goiter ought to remove all pathologically altered tissue, i.e., nodular tissue, irrespective of its appearance on scintiscans.

  4. Distinguishing clinical and imaging features of nodular regenerative hyperplasia and large regenerative nodules of the liver

    Energy Technology Data Exchange (ETDEWEB)

    Ames, J.T. [Departments of Radiology, University of Pittsburgh Medical Center Pittsburgh, Pennsylvania (United States); Federle, M.P., E-mail: federle@stanford.ed [Departments of Radiology, University of Pittsburgh Medical Center Pittsburgh, Pennsylvania (United States); Chopra, K. [Departments of Gastroenterology, University of Pittsburgh Medical Center Pittsburgh, Pennsylvania (United States)

    2009-12-15

    Aim: Nodular regenerative hyperplasia (NRH) and large regenerative nodules (LRN) are distinct types of hepatocellular nodules that have been confused in the radiology literature. However, distinction is critical because their clinical significance is quite different. Our purpose was to review the clinical and imaging findings in a series of patients with NRH and LRN in order to identify distinguishing clinical and imaging features. Materials and methods: This was a retrospective case series. The clinical and imaging features were compared in 36 patients with pathological proof of NRH and 23 patients with pathological evidence of LRN. Results: NRH and LRN have different predisposing factors and imaging findings. NRH is often associated with organ transplantation, myeloproliferative disease, or autoimmune processes. Livers with NRH typically do not have enhancing nodules; none of the present patients with NRH had enhancing liver masses. In contrast, LRN are often associated with Budd-Chiari syndrome. Enhancing liver masses were noted in 19 (83%) of the 23 patients with LRN. The p values for the comparisons were less than 0.001 for both enhancing liver masses and hepatic vein thrombosis. Conclusion: NRH and LRN can have distinct clinical presentations and imaging appearances. LRN often result in enhancing liver nodules, whereas NRH usually does not. Clinical and imaging information enables the distinction of LRN and NRH in many cases.

  5. Clinical characteristics of a group of adults with nodular lymphoid hyperplasia: A single center experience

    Institute of Scientific and Technical Information of China (English)

    Alberto Rubio-Tapia; Jorge Hernéndez-Calleros; Sagrario Trinidad-Hernández; Luis Uscanga

    2006-01-01

    AIM: To describe the clinical and histological characteristics of a group of adults with small-bowel nodular lymphoid hyperplasia (NLH).METHODS: Patients were searched for five years in pathology records of our institution. The biopsy material was reassessed using strict histopathological criteria.Clinical data were obtained from medical records.RESULTS: Small-bowel NLH was diagnosed in 18 cases.The female: male ratio was 2: 1. The most frequent symptoms were diarrhea (72%), involuntary weight loss (72%) and abdominal pain (61%). Nine patients (50%)had immunodeficiency. Small-bowel bacterial overgrowth was found in three (17%) cases. At small-bowel NLH diagnosis, three (17%) had associated lymphoma: two intestinal and one extra-intestinal lymphomas. In two patients with villous atrophy and anti-endomysial antibodies the diagnosis of celiac disease was established.Giardia lamblia infection was found in only one patientwith hypogammaglobulinemia (Herman's syndrome).CONCLUSIONS; NLH is uncommon in adult patients.Associated diseases are immunodeficiency and lymphoid tissue malignancies.

  6. Nodular regenerative hyperplasia: Evolving concepts on underdiagnosed cause of portal hypertension

    Institute of Scientific and Technical Information of China (English)

    Marek Hartleb; Krzysztof Gutkowski; Piotr Milkiewicz

    2011-01-01

    Nodular regenerative hyperplasia (NRH) is a rare liver condition characterized by a widespread benign transformation of the hepatic parenchyma into small regenerative nodules. NRH may lead to the development of non-cirrhotic portal hypertension. There are no published systematic population studies on NRH and our current knowledge is limited to case reports and case series. NRH may develop via autoimmune, hematological, infectious, neoplastic, or drug-related causes. The disease is usually asymptomatic, slowly or nonprogressive unless complications of portal hypertension develop. Accurate diagnosis is made by histopathology, which demonstrates diffuse micronodular transformation without fibrous septa. Lack of perinuclear collagen tissue distinguishes NRH from typical regenerative nodules in the cirrhotic liver. While the initial treatment is to address the underlying disease, ultimately the therapy is directed to the management of portal hypertension. The prognosis of NRH depends on both the severity of the underlying illness and the prevention of secondary complications of portal hypertension. In this review we detail the epidemiology, pathogenesis, diagnosis, management, and prognosis of NRH.

  7. Nodular regenerative hyperplasia: Evolving concepts on underdiagnosed cause of portal hypertension

    Science.gov (United States)

    Hartleb, Marek; Gutkowski, Krzysztof; Milkiewicz, Piotr

    2011-01-01

    Nodular regenerative hyperplasia (NRH) is a rare liver condition characterized by a widespread benign transformation of the hepatic parenchyma into small regenerative nodules. NRH may lead to the development of non-cirrhotic portal hypertension. There are no published systematic population studies on NRH and our current knowledge is limited to case reports and case series. NRH may develop via autoimmune, hematological, infectious, neoplastic, or drug-related causes. The disease is usually asymptomatic, slowly or non-progressive unless complications of portal hypertension develop. Accurate diagnosis is made by histopathology, which demonstrates diffuse micronodular transformation without fibrous septa. Lack of perinuclear collagen tissue distinguishes NRH from typical regenerative nodules in the cirrhotic liver. While the initial treatment is to address the underlying disease, ultimately the therapy is directed to the management of portal hypertension. The prognosis of NRH depends on both the severity of the underlying illness and the prevention of secondary complications of portal hypertension. In this review we detail the epidemiology, pathogenesis, diagnosis, management, and prognosis of NRH. PMID:21472097

  8. 脾硬化性血管瘤样结节样转化的CT与MRI表现(附2例报告及文献复习)%CT and MRI Findings of Sclerosing Angiomatoid Nodular Transformation of the Spleen(Report of 2 Cases with Literature Review)

    Institute of Scientific and Technical Information of China (English)

    张禹; 姚选军; 黄曼; 朱友志; 胡勇

    2010-01-01

    目的 提高对脾硬化性血管瘤样结节样转化(sclerosing angiomatoid nodular transformation,SANT)的CT与MRI表现的认识.资料与方法 报道2例脾SANT患者的CT与MRI表现,并结合文献对其临床和影像学表现及其病理学特征进行分析和讨论.结果 SANT临床表现无特异性,约27%为体检无意发现;33%因其他疾病行检查或剖腹探查时发现;仅35%左右有临床症状或体征.CT与MRI表现特点包括:单发的良性肿块、无包膜和囊变坏死、常有纤维瘢痕、偶见钙化,T2WI常呈低信号、延迟强化.病理特征为多发血管瘤样结节,结节之间环绕同心圆排列的致密胶原纤维组织.结论 SANT是仅见于脾的良性病变,CT与MRI表现虽有一定的特征但定性困难,确诊有赖病理组织学检查.

  9. Focal nodular hyperplasia of the liver in 86 patients

    Institute of Scientific and Technical Information of China (English)

    Ying-Hao Shen; Hui-Chuan Sun; Xiao-Wu Huang; Zhao-You Tang; Jia Fan; Zhi-Quan Wu; Zeng-Chen Ma; Xin-Da Zhou; Jian Zhou; Shuang-Jian Qiu; Lun-Xiu Qin; Qin-Hai Ye

    2007-01-01

    BACKGROUND: Focal nodular hyperplasia (FNH), the second most common benign hepatic tumor after hemangioma, is characterized by a stellate central scar and hyperplastic nodules. Although some large FNH may be associated with signiifcant symptoms, more frequently they are discovered incidentally on physical examination or the work-up of unrelated symptoms. Since its nature and pathogenesis are still controversial, accurate diagnosis of FNH based on clinical presentation and radiographic studies is dififcult. The purpose of this study was to explore the diagnosis and treatment of FNH. METHODS:Eighty-six FNH patients conifrmed patholo-gically were treated at the Liver Cancer Institute in our hospital from 1996 to 2006. Their clinical manifestions, imaging presentation, pathological ifndings, and surgical results were analyzed retrospectively. RESULTS: Of the 86 patients with 99 foci, 54 were male and 32 female, with a mean age of 37 years. Eighty patients had a single solitary focus and 6 had multiple foci. Tumor diameter was less than 5 cm in 69 patients, 5-10 cm in 15, and more than 10 cm in 2. The overall rate of correct preoperative diagnosis was 59.3% (51/86) including 32.9% (26/79) by color Doppler lfow imaging (CDFI), 60.3%(35/58) by CT, and 77.4%(24/31) by MRI. All the 86 patients underwent resection with good curative effect. CONCLUSIONS: CT and MRI are important diagnostic methods for FNH but it is dififcult to make a deifnite preoperative diagnosis for partial classical and all non-classical FNH patients. We suggest that patients with clinical symptoms or with indeifnite diagnosis should accept surgical removal.

  10. Effectiveness of Radioiodine Treatment for Toxic Nodular Goiter

    Directory of Open Access Journals (Sweden)

    Hatice Şakı

    2015-10-01

    Full Text Available Objective: The aim of this retrospective study is to evaluate the treatment outcomes in patients with toxic nodular goiter (TNG that received radioiodine treatment (RAIT and to determine the influence of age, gender, nodule size, I-131 dose, underlying etiology and antithyroid drugs on the outcomes of RAIT. Methods: Two hundred thirty three patients (mean 64±10 years old with TNG that received RAIT were included in the study. Treatment success was analyzed according to demographic (age and gender and clinical data (thyroid function tests before and after RAIT, thyroid sonography and scintigraphy, I-131 dose, antithyroid drugs. A fixed dose of 555 MBq was administered to patients with nodules smaller than 2 cm in diameter and of 740 MBq to patients with nodules larger than 2 cm. Hyperthyroidism treatment success was defined as achieving hypothyroidism or euthyroidism six months after RAIT. Results: In our study, the cure rate was 93.9% six months after RAIT. Hypothyroidism was observed in 74 (31.7% patients, and euthyroidism was achieved in 145 (62.2% patients while 14 (6% patients remained in hyperthyroid state. Age and gender did not affect treatment outcomes. No correlation was found between underlying etiology or antithyroid drugs and therapeutic effectiveness. The effectiveness of RAIT was better in patients with nodules smaller than 2 cm. Conclusion: We observed that high cure rates were obtained in patients with TNG with 555 MBq and 740 MBq doses of I-131. While nodule diameter and RAI dose are important factors for treatment efficacy; age, gender, underlying etiology and antithyroid drugs do not affect the outcome of RAIT.

  11. Ultrasonographic Differentiation Between Nodular Hyperplasia and Neoplastic Follicular-Patterned Lesions of the Thyroid Gland.

    Science.gov (United States)

    Song, Yong Sub; Kim, Ji-Hoon; Na, Dong Gyu; Min, Hye Sook; Won, Jae-Kyung; Yun, Tae Jin; Choi, Seung Hong; Sohn, Chul-Ho

    2016-08-01

    We evaluate the gray-scale ultrasonographic characteristics that differentiate between nodular hyperplasia (NH) and neoplastic follicular-patterned lesions (NFPLs) of the thyroid gland. Ultrasonographic features of 750 patients with 832 thyroid nodules (NH, n = 361; or NFPLs, follicular adenoma, n = 123; follicular carcinoma, n = 159; and follicular variant papillary carcinoma, n = 189) were analyzed. Except for echogenicity, over two-thirds of the cases of NH and NFPLs share the ultrasonographic characteristics of solid internal content, a well-defined smooth margin and round-to-ovoid shape. Independent predictors for NH were non-solid internal content (sensitivity 27.1%, specificity 90.2%), isoechogenicity (sensitivity 69.5%, specificity 63.5%) and an ill-defined margin (sensitivity 18.8%, specificity 94.5%). Independent predictors for NFPLs were hypoechogenicity (sensitivity 60.5%, specificity 70.4%), marked hypoechogenicity (sensitivity 2.8%, specificity 99.4%) and taller-than-wide shape (sensitivity 6.6%, specificity 98.1%). Although NH and NFPLs commonly share ultrasonographic characteristics, non-solid internal content and ill-defined margin are specific to NH and marked hypoechogenicity and taller-than-wide shape are specific to NFPLs.

  12. Coexisting Sclerosing Angiomatoid Nodular Transformation of the Spleen with Multiple Calcifying Fibrous Pseudotumors in a Patient

    Directory of Open Access Journals (Sweden)

    Jen-Chieh Lee

    2007-01-01

    Full Text Available Primary tumor or tumor-like lesions of the spleen are rare. Among them, vascular lesions are the most common. Vascular tumor of the spleen is different from the usual hemangioma of soft tissue because the vascular structure of the spleen is unique. Sclerosing angiomatoid nodular transformation (SANT is a recently described vascular lesion of the spleen. Grossly, it is a multinodular, well-circumscribed tumor containing a hypervascular core. Microscopically, it comprises three types of vessels, and each type recapitulates the immunohistochemical characteristics of the normal vascular elements of the splenic red pulp, i.e. capillaries, sinusoids, and small veins, respectively. Because of the rarity of this entity, its actual pathogenesis is still unknown. In this study, we report a case of SANT occurring in a 43-year-old woman, in whom there were also multiple calcifying fibrous pseudotumors (CFPTs in the abdominal cavity. Both SANT and CFPT are thought to be variants of inflammatory pseudotumor. Coexistence of these two rare entities in a patient has never been reported, and this fact suggests that there might be a common mechanism contributing to the formation of these two types of lesions. [J Formos Med Assoc 2007;106(3:234-239

  13. Confocal Microscopy–Guided Laser Ablation for Superficial and Early Nodular Basal Cell Carcinoma

    Science.gov (United States)

    Chen, Chih-Shan Jason; Sierra, Heidy; Cordova, Miguel; Rajadhyaksha, Milind

    2014-01-01

    Importance Laser ablation is a rapid and minimally invasive approach for the treatment of superficial skin cancers, but efficacy and reliability vary owing to lack of histologic margin control. High-resolution reflectance confocal microscopy (RCM) may offer a means for examining margins directly on the patient. Observations We report successful elimination of superficial and early nodular basal cell carcinoma (BCC) in 2 cases-, using RCM imaging to guide Er-:YAG laser ablation. Three-dimensional (3-D) mapping is feasible with RCM-, to delineate the lateral border and thickness of the tumor. Thus, the surgeon may deliver laser fluence and passes with localized control—ie, by varying the ablation parameters in sub-lesional areas with specificity that is governed by the 3-D topography of the BCC. We further demonstrate intra-operative detection of residual BCC after initial laser ablation and complete removal of remaining tumor by additional passes. Both RCM imaging and histologic sections confirm the final clearance of BCC. Conclusions and Relevance Confocal microscopy may enhance the efficacy and reliability of laser tumor ablation. This report represents a new translational application for RCM imaging, which, when combined with an ablative laser, may one day provide an efficient and cost-effective treatment for BCC. PMID:24827701

  14. Congenital infiltrating lipomatosis of the face with ipsilateral hemimegalencephaly, band heterotopia, and hypertrophy of brainstem and cerebellum.

    Science.gov (United States)

    Maruyama, Koichi; Okumura, A; Negoro, T; Watanabe, K

    2010-06-01

    The simultaneous appearance of congenital infiltrating lipomatosis of the face that causes facial hemihypertrophy and ipsilateral hemimegalencephaly is extremely rare. We report a 4-year-old boy with congenital facial asymmetry and infantile-onset epilepsy. Magnetic resonance imaging (MRI) results led to the diagnosis of infiltrating lipomatosis of the face; the diagnosis was confirmed on the basis of the results of pathological examinations. Additionally, brain MRI revealed ipsilateral hemimegalencephaly, associated with band heterotopia and the hemihypertrophy of the ipsilateral brainstem and cerebellum. He had no nevi or other skin abnormalities suggesting neurocutaneous syndrome. His seizures were so intractable that they necessitated functional hemispherectomy. The lipomatous lesion was successfully resected without relapse. Psychomotor delay and left hemiplegia were observed at the last follow-up. © Georg Thieme Verlag KG Stuttgart · New York.

  15. Diffuse duodenal nodular lymphoid hyperplasia: a large cohort of patients etiologically related to Helicobacter pylori infection

    Science.gov (United States)

    2011-01-01

    Background Nodular lymphoid hyperplasia of gastrointestinal tract is a rare disorder, often associated with immunodeficiency syndromes. There are no published reports of its association with Helicobacter pylori infection. Methods From March 2005 till February 2010, we prospectively followed all patients with diffuse duodenal nodular lymphoid hyperplasia (DDNLH). Patients underwent esophagogastroduodenoscopy with targeted biopsies, colonoscopy, and small bowel video capsule endoscopy. Duodenal nodular lesions were graded from 0 to 4 based on their size and density. Patients were screened for celiac sprue (IgA endomysial antibody), immunoglobulin abnormalities (immunoglobulin levels & serum protein electrophoresis), small intestine bacterial overgrowth (lactulose hydrogen breath test), and Helicobacter pylori infection (rapid urease test, and histological examination of gastric biopsies). Patients infected with Helicobacter pylori received sequential antibiotic therapy and eradication of infection was evaluated by 14C urea breath test. Follow up duodenoscopies with biopsies were performed to ascertain resolution of nodular lesions. Results Forty patients (Males 23, females 17; mean age ± 1SD 35.6 ± 14.6 years) with DDNLH were studied. Patients presented with epigastric pain, vomiting, and weight loss. Esophagogastroduodenoscopy showed diffuse nodular lesions (size varying from 2 to 5 mm or more) of varying grades (mean score ± 1SD 2.70 ± 0.84) involving postbulbar duodenum. Video capsule endoscopies revealed nodular disease exclusively limited to duodenum. None of the patients had immunoglobulin deficiency or small intestine bacterial overgrowth or positive IgA endomysial antibodies. All patients were infected with Helicobacter pylori infection. Sequential antibiotic therapy eradicated Helicobacter pylori infection in 26 patients. Follow up duodenoscopies in these patients showed significant reduction of duodenal nodular lesions score (2.69 ± 0.79 to 1.50 ± 1

  16. Genetic and non-iodine-related factors in the aetiology of nodular goitre.

    Science.gov (United States)

    Knudsen, Nils; Brix, Thomas Heiberg

    2014-08-01

    Genetic and a large number of environmental non-iodine-related factors play a role in the cause of nodular goitre. Most evidence for the influence of genetic and environmental factors in the cause of goitre is from cross-sectional, population-based studies. Only a few studies have included prospective data on risk factors for nodular goitre, although few prospective data are available on the effect of iodine and tobacco smoking on goitre development. Goitre is not one single phenotype. Many epidemiological studies do not distinguish diffuse from nodular goitre, as the investigated parameter is often thyroid volume or frequency with increased thyroid volume. Moreover, information on the presence and effect of gene-environment, gene-gene, and environment-environment effect modifications is limited. Thus, firm conclusions about the relative contributions and causality of the investigated risk factors should be made with caution. Smoking seems to be an established risk factor for nodular goitre, possibly with effect modification from iodine intake, as the risk associated with smoking is smaller or absent in areas with sufficient iodine intake. The use of oral contraceptives might have protective effects against goitre, and childbirth is an increased risk factor for goitre in areas with non-optimal iodine intake. Insulin resistance is a recently investigated risk factor, and the risk of goitre may be reversible with metformin treatment. Iodine remains the major environmental risk factor for nodular goitre.

  17. Effect of Gamma Irradiation on Regeneration Capacity of Mangosteen Nodular Callus

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    WARID ALI QOSIM

    2007-12-01

    Full Text Available The research was conducted to determine the effect of gamma irradiation on regeneration capacity of mangosteed nodular callus. Nodular calli derived from a leaf as explants and cultured on MS medium containing combination of 2.2 µM benzilaminopurin (BAP and 2.27 µM tidiazuron (TDZ. Nodular calli were irradiated with 0 (control 5, 10, 15, 20, 25, 30, 35, and 40 Gy doses of gamma irradiation. After the irradiation, the calli were generated on woody plant medium (WPM, supplemented with 1.39 µM polyvinilpirolidon (PVP, 8 g.l-1 agar, 30 g.l-1 sucrose and 2.2 µM BAP concentration. Results showed that the irradiation influence the plant regeneration. Response dose of 50% (RD that could promote the nodular calli of shoot formation was the 25 Gy while that of the shoot number per nodular calli was the 21 Gy. The shoot number irradiated with total dose 5 Gy (9.1 shoot was higher than that of 0 Gy (8.6 shoot.

  18. Advanced Age and Mild Thyrotoxicosis are Associated with Nodular Goiter in Graves Disease

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    Serkan Yener

    2009-06-01

    Full Text Available Objective: The primary goal of this study is to evaluate predictors of nodular goiter in Graves Disease (GD.Materials and Methods: A total of 202 consecutive patients (mean age: 45; 145 female, 57 male were enrolled. All patients were treated with antithyroid drugs as initial therapy. TSH, FT3, FT4, TRAb, ATPO, and ATG were measured. Radioactive iodine uptake and thyroid ultrasonography were performed, and thyroid volume and nodule diameter were assessed. Ultrasound-guided fine needle aspiration was performed on thyroid nodules ≥8mm. Results: Diffuse goiter was detected in 51% of patients. Solitary nodules were detected in 16%, and multi-nodular disease in 33%. Mean nodule diameter was 8.82 mm. Nodular disease was slightly more common in women (p=0.063. Patients with nodular GD were older (p=0.004, had lower levels of FT3 (p=0.016 and TRAB (p=0.002 when compared with subjects with diffuse GD. Age (OR:6.867 was the independent variable predicting nodular GD. Conclusion: Increased prevalence of nodules was associated with advanced age and milder thyrotoxicosis. Apoptosis of thyroid follicular cells due to excess iodine might interfere with nodule formation, and lead to diffuse goiter in severe thyrotoxicosis. Because of increased rate if malignancy in GD, comprehensive evaluation of thyroid nodules of any size is mandatory. Turk Jem 2009; 13: 1-4

  19. Testate amoeba Rhogostoma minus Belar, 1921, associated with nodular gill disease of rainbow trout, Oncorhynchus mykiss (Walbaum).

    Science.gov (United States)

    Dyková, I; Tyml, T

    2016-05-01

    The case study targeted to determine the aetiology of nodular gill disease (NGD) of farmed rainbow trout. The methods included microscopical examination of gill material in fresh, culturing of isolated organisms, histology, transmission electron microscopy and molecular biology identification. The results revealed an intravital colonization of fish gills by the testate amoeba Rhogostoma minus Belar, 1921. Rhogostoma infection was found in all fish examined microscopically (15/15); in contrast, naked amoebae related to fully developed NGD lesions were found in minority of these fish (5/15). They belonged to four genera, Acanthamoeba, Vermamoeba, Naegleria and Vannella. Results presented in this study contribute to the mosaic of findings that contrary to amoebic gill disease of marine fish turn attention to the possibility of the heterogeneous, multi-amoeba-species and multifactorial aetiology of NGD.

  20. Chromium and copper influence on the nodular cast iron with carbides microstructure

    Directory of Open Access Journals (Sweden)

    G. Gumienny

    2010-10-01

    Full Text Available In this paper chromium to 1,00% and copper to 1,50% influence at constant molybdenum content of about 1,50% on the nodular cast ironwith carbides microstructure has been presented. It was found, that as a result of synergic addition of above-mentioned elements there isthe possibility obtaining an ausferrite in nodular cast iron with carbides castings. Conditions have been given, when in nodular cast iron with carbides at cooling at first in the form, then air-cooling austenite transformation to upper bainite, its mixture with lower bainite, martensite or ausferrite takes place. Transformations proceed during cooling and the crystallization of cast iron have been determined and the casting hardness has been presented.

  1. The Effect of Nodular Cast Iron Metal Matrix on the Wear Resistance

    Directory of Open Access Journals (Sweden)

    G. Gumienny

    2012-04-01

    Full Text Available The paper presents results of studies on the effect of the nodular cast iron metal matrix composition on the abrasive and adhesive wear resistance. Nodular cast iron with different metal matrix obtained in the rough state and ADI were tested. To research of abrasive and adhesive wear the pearlitic and bainitic cast iron with carbides and without this component were chosen. The influence of the carbides amount for cast iron wear resistance was examined. It was found, that the highest abrasive and adhesive wear resistance under conditions of dry friction has a nodular cast iron with carbides with upper and lower bainite. Carbides in bainitic and pearlitic cast iron significantly increase the wear resistance in these conditions. In terms of fluid friction the largest wear resistance had cast iron group with the highest hardness.

  2. Genetic and non-iodine-related factors in the aetiology of nodular goitre

    DEFF Research Database (Denmark)

    Knudsen, Nils; Brix, Thomas Heiberg

    2014-01-01

    Genetic and a large number of environmental non-iodine-related factors play a role in the cause of nodular goitre. Most evidence for the influence of genetic and environmental factors in the cause of goitre is from cross-sectional, population-based studies. Only a few studies have included...... prospective data on risk factors for nodular goitre, although few prospective data are available on the effect of iodine and tobacco smoking on goitre development. Goitre is not one single phenotype. Many epidemiological studies do not distinguish diffuse from nodular goitre, as the investigated parameter...... is often thyroid volume or frequency with increased thyroid volume. Moreover, information on the presence and effect of gene-environment, gene-gene, and environment-environment effect modifications is limited. Thus, firm conclusions about the relative contributions and causality of the investigated risk...

  3. Nodular Gastritis and Pathologic Findings in Children and Young Adults with Helicobacter pylori Infection

    Science.gov (United States)

    Koh, Hong; Noh, Tae-Woong; Baek, Seoung-Yon

    2007-01-01

    Purpose The aim of this study was to investigate the pathologic characteristics of nodular gastritis in children and young adults infected with Helicobacter pylori (H. pylori). Materials and Methods A total of 328 patients were enrolled in this study, and the diagnosis of H. pylori infection was done with gastroduodenal endoscopy concomitant with a CLO™ test and pathologic analysis of the biopsy specimens. Diagnoses of normal, superficial gastritis, nodular gastritis, and peptic ulcer disease were made from the gastroduodenal endoscopic findings. The density of H. pylori organisms in the gastric mucosa was rated as normal, mild, moderate, or marked. The pathologic findings of nodular gastritis were based on the histopathologic findings of inflammation, immune activity, glandular atrophy and intestinal metaplasia. Each of these findings was scored as either normal (0), mild (1), moderate (2), or marked (3) according to the updated Sydney system and using visual analog scales. The gastritis score was the sum of the four histopathologic scores. Results In this study, nodular gastritis (50.6%) was most common, and mild density (51.5%) H. pylori infection was also common upon microscopic examination. Intestinal metaplasia occurred in 9 patients (2.7%). Conclusion Logistic regression revealed a significant increase in the incidence of nodular gastritis with gastritis score (p = 0.008), but not an association with sex, age, or H. pylori density. Gastritis score was the only significant factor influencing the occurrence of nodular gastritis. Intestinal metaplasia, which was originally thought to be a pre-malignant lesion, occurred in 2.7% of the patients with H. pylori infection. PMID:17461522

  4. A 65-year-old man with persistent cough and large nodular opacity.

    Science.gov (United States)

    Grimes, Brandon S; Albores, Jeffrey; Barjaktarevic, Igor

    2015-01-01

    A 65-year-old Asian man with a history of chronic hepatitis B infection presented to our pulmonary clinic for second opinion of his chronic, persistent, nonproductive cough. He was evaluated 10 months earlier with chest CT scan, which revealed a large lingular nodular opacity that was diagnosed as nodular cryptogenic organizing pneumonia by CT scan-guided percutaneous lung biopsy. Systemic corticosteroids were initiated and continued over the next 10 months. The dry cough persisted, and he developed intermittent left-sided pleuritic chest pain. He denied fevers, night sweats, hemoptysis, weight loss, or dyspnea. He was a lifelong nonsmoker and moved to the United States from China during childhood.

  5. The effect of high-frequencies loading on the fatigue cracking of nodular cast iron

    Directory of Open Access Journals (Sweden)

    R. Ulewicz

    2017-01-01

    Full Text Available The article presents the results of fatigue tests using high-frequency loading of nodular cast iron. Nodular cast iron GJS-500-7, GJS-600-3 and cast iron ADI with a tensile strength of Rm = 1 125 MPa were used for the tests. The fatigue tests were conducted on a resonance testing machine. For the cast iron grades under investigation, fatigue characteristics in high and ultra-high-cycle regions were experimentally determined. After the completion of the tests, the fractographic analysis of fatigue fractures was made with the aim of determining the fatigue crack initiation location and the fracture mechanism.

  6. Fascitis nodular de presentación intraoral. Revisión

    Directory of Open Access Journals (Sweden)

    Ignacio Venturino

    2017-04-01

    Se presenta un caso clínico en una mujer de 23 años de edad con un tumor en encía inferior, de 2 meses de evolución. Se realizó la escisión quirúrgica con diagnóstico de fascitis nodular sin que se observara recurrencia a los 18 meses. Además, se revisan los casos publicados de fascitis nodular de presentación intraoral en los últimos 20 años.

  7. Electronic brachytherapy for superficial and nodular basal cell carcinoma: a report of two prospective pilot trials using different doses

    Directory of Open Access Journals (Sweden)

    Rosa Ballester-Sánchez

    2016-01-01

    Full Text Available Purpose : Basal cell carcinoma (BCC is a very common cancer in the Caucasian population. Treatment aims to eradicate the tumor with the lowest possible functional and aesthetic impact. Electronic brachytherapy (EBT is a treatment technique currently emerging. This study aims to show the outcomes of two consecutive prospective pilot clinical trials using different radiation doses of EBT with Esteya® EB system for the treatment of superficial and nodular basal cell carcinoma. Material and methods : Two prospective, single-center, non-randomized, pilot studies were conducted. Twenty patients were treated in each study with different doses. The first group (1 was treated with 36.6 Gy in 6 fractions of 6.1 Gy, and the second group (2 with 42 Gy in 6 fractions of 7 Gy. Cure rate, acute toxicity, and late toxicity related to cosmesis were analyzed in the two treatment groups. Results: In group 1, a complete response in 90% of cases was observed at the first year of follow-up, whereas in group 2, the complete response was 95%. The differences with reference to acute toxicity and the cosmetic results between the two treatment groups were not statistically significant. Conclusions : Our initial experience with Esteya® EB system to treat superficial and nodular BCC shows that a dose of 36.6 Gy and 42 Gy delivered in 6 fraction of 7 Gy achieves a 90% and 95% clinical cure rate at 1 year, respectively. Both groups had a tolerable toxicity and a very good cosmesis. The role of EBT in the treatment of BCC is still to be defined. It will probably become an established option for selected patients in the near future.

  8. Metastatic ocular melanoma to the liver exhibits infiltrative and nodular growth patterns

    DEFF Research Database (Denmark)

    Grossniklaus, Hans E; Zhang, Qing; You, Shuo

    2016-01-01

    We examined liver specimens from 15 patients with uveal melanoma (UM) who had died of their disseminated disease. We found 2 distinct growth patterns of UM metastasis: infiltrative (n = 12) and nodular (n = 3). In the infiltrative pattern, individual UM cells with a CD133+ cancer stem cell-like p...

  9. Seasonal changes in nodular nitrogenase activity of Alnus glutinosa and Elaeagnus angustifolia.

    Science.gov (United States)

    Zitzer, S F; Dawson, J O

    1989-06-01

    Root nodule development, and seasonal patterns of nodular nitrogenase and hydrogenase activities were determined for 5- to 8-year old black alder (Alnus glutinosa (L.) Gaertn.) and Russian olive (Elaeagnus angustifolia L.) interplanted with black walnut (Juglans nigra L.) on bottomland and upland sites in central Illinois, USA. Black alder produced nodules at both sites, but Russian olive did so only at the bottomland site. Nodular nitrogenase activity was detectable in both species over a 220-day period. Maximum, midday rates of nitrogenase activity (acetylene reduction) of 15 to 20 micromoles C(2)H(4) per g dry nodule per hour were maintained by black alder for approximately 150 days at both the upland and bottomland sites. Near maximum rates of nodular nitrogenase activity were maintained for a similar period by Russian olive at the lowland site, although specific nitrogenase activity was approximately 25% lower than in black alder owing to a larger proportion of necrotic nodular tissue in Russian olive. In both species, nitrogenase activity increased exponentially with temperature between 10 degrees C and 20 to 25 degrees C. No net hydrogen evolution by nodules of either species was detected at any time during the assay period, indicating efficient hydrogenase systems were operating under the conditions of the field assay. Height of black walnut interplanted with nodulated black alder and Russian olive was greater than that of black walnut grown in pure stands.

  10. Ultrasonic scores of conventional ultrasound and ultrasound elastography in the diagnosis of thyroid nodular lesions

    Institute of Scientific and Technical Information of China (English)

    鄢曹鑫

    2013-01-01

    Objective To explore the values of total ultrasonic scores of conventional ultrasound and ultrasound elastography in the diagnosis of thyroid nodular lesions.Methods A total of 347 thyroid nodules proved by fine-needle aspiration cytology (FNAC) and surgery underwent

  11. Sonographic Findings of Hashimoto's Thyroiditis and Associated Nodular Lesions

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Bong Joo; Park, Young Ha; Jung, So Lyung; Chung, Soo Kyo [Catholic University of Korea College of Medicine, Seoul (Korea, Republic of)

    2007-12-15

    To evaluate the sonographic findings of Hashimoto's thyroiditis and associated nodular lesions. We retrospectively reviewed the sonographic findings of twenty patients who had surgically confirmed Hashimoto's thyroiditis between 1 March 2005, and 26 November 2005. In these patients, we reviewed the sonographic findings of the associated focal nodular lesion. Assessed were size, homogeneity, and echogenicity of the diseased thyroid gland and shape, echogenicity, margin, rim, microcal cification of the associated nodules. Without knowledge of the pathological diagnosis of the nodular lesions, based on the sonographic criteria, the nodules were classified as either malignant or benign. Hashimoto's thyroiditis demonstrates a variety of sonographic findings for size, homogeneity, and echogenicity. Among the nineteen nodules that were sonographically diagnosed and pathologically confirmed, nine papillary cancers, seven nodular hyperplasias, two Huthle cell adenomas, and one focal hyalinized fibrosing nodule were included. All of the nine papillary cancers showed more than one malignant finding such as marked hypoechogenicity, an irregular shape, a taller than wide shape, a spiculated margin, or microcalcifications that were classified as malignant nodulea, and all of the ten benign nodules showed no malignant findings. Circumscribed isoechoic, hyperechoic, or hypoechoic nodules without calcification were classified as bending nodules. Hashimoto's thyroiditis demonstrates various findings on a sonographic examination,and associated various benign and malignant lesions. Moreover, a sonographic examination is helpful to differentiate between malignant and benign lesions in Hashimoto's thyroiditis as in the normal thyroid

  12. Animal models of disease: feline hyperthyroidism: an animal model for toxic nodular goiter.

    Science.gov (United States)

    Peterson, Mark E

    2014-11-01

    Since first discovered just 35 years ago, the incidence of spontaneous feline hyperthyroidism has increased dramatically to the extent that it is now one of the most common disorders seen in middle-aged to senior domestic cats. Hyperthyroid cat goiters contain single or multiple autonomously (i.e. TSH-independent) functioning and growing thyroid nodules. Thus, hyperthyroidism in cats is clinically and histologically similar to toxic nodular goiter in humans. The disease in cats is mechanistically different from Graves' disease, because neither the hyperfunction nor growth of these nodules depends on extrathyroidal circulating stimulators. The basic lesion appears to be an excessive intrinsic growth capacity of some thyroid cells, but iodine deficiency, other nutritional goitrogens, or environmental disruptors may play a role in the disease pathogenesis. Clinical features of feline toxic nodular goiter include one or more palpable thyroid nodules, together with signs of hyperthyroidism (e.g. weight loss despite an increased appetite). Diagnosis of feline hyperthyroidism is confirmed by finding the increased serum concentrations of thyroxine and triiodothyronine, undetectable serum TSH concentrations, or increased thyroid uptake of radioiodine. Thyroid scintigraphy demonstrates a heterogeneous pattern of increased radionuclide uptake, most commonly into both thyroid lobes. Treatment options for toxic nodular goiter in cats are similar to that used in humans and include surgical thyroidectomy, radioiodine, and antithyroid drugs. Most authorities agree that ablative therapy with radioiodine is the treatment of choice for most cats with toxic nodular goiter, because the animals are older, and the disease will never go into remission.

  13. Effect of Lanthanum on Nodule Count and Nodularity of Ductile Iron

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The present study aims at finding out the effect of the addition of a single rare earth element, that is, lanthanum on the nodularity and nodule count of ductile iron under controlled conditions. For this purpose, four melts with different compositions were made, using a 28 kg inductotherm medium frequency induction furnace. The temperature was carefully maintained between 1400 and 1450 ℃ for these heats. A good quality charge consisting of Sorel metal, ferrosilicon, Swedish iron, ferrosilicon magnesium, and ferrosilicon lanthanum was used for the production of melts. A vertically parted sand mould was used for casting of 10 test bars made from local silica sand. Standard coin samples were chill-cast to conduct chemical analysis of the ductile iron. Microstructure study of the samples was conducted using a Leica optical microscope. Nodule count and nodularity of the samples were carried out using an image analyzer. The results obtained indicated that with the increased addition of lanthanum the nodule count of ductile iron increased, thus making it evident that it played a significant role in increasing the mechanical properties. The highest nodule count of 467 was obtained with the addition of 0.03% lanthanum. However, the effect of lanthanum on nodularity was negligible with nodularity ranging from 81% to 83%.

  14. Diagnosing nodular regenerative hyperplasia of the liver is thwarted by low interobserver agreement

    NARCIS (Netherlands)

    B. Jharap (Bindia); Van Asseldonk, D.P. (Dirk P.); N.K.H. de Boer (Nanne); Bedossa, P. (Pierre); Diebold, J. (Joachim); Jonker, A.M. (A. Mieke); Leteurtre, E. (Emmanuelle); J. Verheij (Joanne); Wendum, D. (Dominique); Wrba, F. (Fritz); P.E. Zondervan (Pieter); J.F. Colombel (Jean Frédéric); W. Reinisch (Walter); C.J.J. Mulder (Chris); E. Bloemena (Elisabeth); A.A. van Bodegraven (Ad); Cosnes, J. (Jacques); C.M.J. van Nieuwkerk; Seiderer, J. (Julia); Vernier-Massouille, G. (Gwenola)

    2015-01-01

    textabstractBackground and Aims: Nodular regenerative hyperplasia (NRH) of the liver is associated with several diseases and drugs. Clinical symptoms of NRH may vary from absence of symptoms to full-blown (noncirrhotic) portal hypertension. However, diagnosing NRH is challenging. The objective of th

  15. Synthesis of nanoparticles of vanadium carbide in the ferrite of nodular cast iron

    CERN Document Server

    Fras, E; Guzik, E; Lopez, H

    2005-01-01

    The synthesis method of nanoparticles of vanadium carbide in nodular cast iron is presented. After introduction of this method, the nanoparticles with 10-70 nm of diameter was obtained in the ferrite. The diffraction investigations confirmed that these particles are vanadium carbides of type V/sub 3/C/sub 4/.

  16. Heterotopia pancreática: análise clínico-patológica de 18 doentes

    Directory of Open Access Journals (Sweden)

    Sansom Henrique Bromberg

    Full Text Available OBJETIVO: Analisar as características clínico-patológicas do tecido pancreático heterotópico em órgãos digestivos abdominais. MÉTODOS: Realizamos estudo retrospectivo analisando 18 portadores de pâncreas heterotópico diagnosticados histologicamente. Seus dados clínicos e histopatológicos foram revistos. O tecido pancreático heterotópico foi classificado em três modelos histológicos: tipo I constituído por três componentes do pâncreas normal (ácinos, ductos e ilhotas, tipo II com dois componentes e tipo três com somente um componente. RESULTADOS: A média de idade foi de 52,7 anos, variando de 34 a 73 anos, com nove homens e nove mulheres. Sintomas foram observados em somente quatro doentes, sendo suas lesôes diagnosticadas por gastroscopia. Os 14 restantes eram assintomáticos e suas anomalias descobertas acidentalmente. A maioria das lesões situava-se no trato superior: sete (38,9% no estômago, seis (33,3% no duodeno e três (16,6% no jejuno. A heterotopia localizou-se preferencialmente na submucosa (83,3%, mas também foi observada na muscular própria e na sub-serosa. Em sete (38,9% espécimes todos os componentes pancreáticos foram constatados (tipo I, em oito (44,4% estavam presentes glândulas exócrinas e ductos excretores (tipo II e em três (16,7% somente o tecido exócrino foi observado (tipo III. CONCLUSÃO: A heterotopia pancreática é rara. Doentes com ectopia pancreática diagnosticadas pelo estudo patológico, assintomáticos ou com sintomas discretos devem permanecer em observação. As lesões detectadas acidentalmente durante procedimentos cirúrgicos necessitam ser removidas por procedimentos conservadores.

  17. Nodular lymphocyte predominant Hodgkin lymphoma: a Lymphoma Study Association retrospective study

    Science.gov (United States)

    Lazarovici, Julien; Dartigues, Peggy; Brice, Pauline; Obéric, Lucie; Gaillard, Isabelle; Hunault-Berger, Mathilde; Broussais-Guillaumot, Florence; Gyan, Emmanuel; Bologna, Serge; Nicolas-Virelizier, Emmanuelle; Touati, Mohamed; Casasnovas, Olivier; Delarue, Richard; Orsini-Piocelle, Frédérique; Stamatoullas, Aspasia; Gabarre, Jean; Fornecker, Luc-Matthieu; Gastinne, Thomas; Peyrade, Fréderic; Roland, Virginie; Bachy, Emmanuel; André, Marc; Mounier, Nicolas; Fermé, Christophe

    2015-01-01

    Nodular lymphocyte predominant Hodgkin lymphoma represents a distinct entity from classical Hodgkin lymphoma. We conducted a retrospective study to investigate the management of patients with nodular lymphocyte predominant Hodgkin lymphoma. Clinical characteristics, treatment and outcome of adult patients with nodular lymphocyte predominant Hodgkin lymphoma were collected in Lymphoma Study Association centers. Progression-free survival (PFS) and overall survival (OS) were analyzed, and the competing risks formulation of a Cox regression model was used to control the effect of risk factors on relapse or death as competing events. Among 314 evaluable patients, 82.5% had early stage nodular lymphocyte predominant Hodgkin lymphoma. Initial management consisted in watchful waiting (36.3%), radiotherapy (20.1%), rituximab (8.9%), chemotherapy or immuno-chemotherapy (21.7%), combined modality treatment (12.7%), or radiotherapy plus rituximab (0.3%). With a median follow-up of 55.8 months, the 10-year PFS and OS estimates were 44.2% and 94.9%, respectively. The 4-year PFS estimates were 79.6% after radiotherapy, 77.0% after rituximab alone, 78.8% after chemotherapy or immuno-chemotherapy, and 93.9% after combined modality treatment. For the whole population, early treatment with chemotherapy or radiotherapy, but not rituximab alone (Hazard ratio 0.695 [0.320–1.512], P=0.3593) significantly reduced the risk of progression compared to watchful waiting (HR 0.388 [0.234–0.643], P=0.0002). Early treatment appears more beneficial compared to watchful waiting in terms of progression-free survival, but has no impact on overall survival. Radiotherapy in selected early stage nodular lymphocyte predominant Hodgkin lymphoma, and combined modality treatment, chemotherapy or immuno-chemotherapy for other patients, are the main options to treat adult patients with a curative intent. PMID:26430172

  18. 结节性筋膜炎的临床影像特点及筋膜尾征的诊断效能%Clinical and imaging characteristics of nodular fasciitis and diagnosis efficiency of fascial tail sign

    Institute of Scientific and Technical Information of China (English)

    孙俊旗; 单菲菲; 程英; 孟志华

    2016-01-01

    Objective To explore the imaging characteristics of nodular fasciitis and the diagnosis efficiency of fascia tail sign at MR images in the nodular fasciitis. Methods The clinical datas and MRI imaging signs of nodular fasciitis pathology confirmed in 23 cases were retrospectively analyzed. Image features include the position,size,signal characteristics,enhancement pattern,and fascia tail sign. Sensitivity and specificity of fascia tail sign were calculated in the diagnosis of nodular fasciitis. The association between the presence of fascia tail sign and nodular fasciitis was analyzed. Results 23 cases of nodular fasciitis were a single sol-id nodules or masses. The most common was located in the upper limbs. most lesions was less than 4cm. MRI image showed T 1WI was the same signal,T2WI was high signal,and enhanced T1WI displayed significantly enhanced. Fascia tail sign was present in 19 cases,with sensitivity of 83.8%,specificity of 79.5%. Fascia tail sign and nodular fasciitis have significant correlation (r=0.714). Conclusion The clinical features and imaging performance of nodular fasciitis,especially significantly diagnostic performance of the fascia tail sign,can be made on the part imaging diagnosis of nodular fasciitis.%目的:探讨结节性筋膜炎的病理、临床特点和MRI影像征象。方法回顾外科手术和病理证实35例结节性筋膜炎,最终23例MRI图像。图像特征包括位置,大小,信号特征,强化方式,筋膜尾征。计算筋膜尾征在结节性筋膜炎诊断的敏感度、特异度,与结节性筋膜炎的相关性。结果23结节性筋膜炎单发实性结节或肿块,最常见位于上肢,83%病变范围小于4cm,MRI影像表现为T1WI呈等信号,T2WI呈高信号,增强后明显强化。19例出现筋膜尾征,筋膜尾征对结节性筋膜炎诊断的敏感度为83.8%,特异度为79.5%,筋膜尾征与结节性筋膜炎显著相关性(r=0.714)。结论结节

  19. Hepatic focal nodular hyperplasia in children: Imaging features on multi-slice computed tomography

    Institute of Scientific and Technical Information of China (English)

    Qing-Yu Liu; Wei-Dong Zhang; Dong-Ming Lai; Ying Ou-yang; Ming Gao; Xiao-Feng Lin

    2012-01-01

    AIM:To retrospectively analyze the imaging features of hepatic focal nodular hyperplasia (FNH) in children on dynamic contrast-enhanced multi-slice computed tomography (MSCT) and computed tomography angiography (CTA) images.METHODS:From September 1999 to April 2012,a total of 218 cases of hepatic FNH were confirmed by either surgical resection or biopsy in the Sun Yat-sen Memorial Hospital of Sun Yat-sen University and the Cancer center of Sun Yat-sen University,including 12 cases (5.5%) of FNH in children (age ≤ 18 years old).All the 12 pediatric patients underwent MSCT.We retrospectively analyzed the imaging features of FNH lesions,including the number,location,size,margin,density of FNH demonstrated on pre-contrast and contrastenhanced computed tomography (CT) scanning,central scar,fibrous sepia,pseudocapsule,the morphology of the feeding arteries and the presence of draining vessels (portal vein or hepatic vein).RESULTS:All the 12 pediatric cases of FNH had solitary lesion.The maximum diameter of the lesions was 4.0-12.9 cm,with an average diameter of 5.5 ± 2.5 cm.The majority of the FNH lesions (10/12,83.3%) had well-defined margins.Central scar (10/12,83.3%) and fibrous septa (11/12,91.7%) were commonly found in children with FNH.Central scar was either isodense (n =7) or hypodense (n =3) on pre-contrast CT images and showed progressive enhancement in 8 cases in the equilibrium phase.Fibrous septa were linear hypodense areas in the arterial phase and isodense in the portal and equilibrium phases.Pseudocapsule was very rare (1/12,8.3%) in pediatric FNH.With the exception of central scars and fibrous septa within the lesions,all 12 cases of pediatric FNH were homogenously enhanced on the contrast-enhanced CT images,significantly hyperdense in the arterial phase (12/12,100.0%),and isodense in the portal venous phase (7/12,58.3%) and equilibrium phase (11/12,91.7%).Central feeding arteries inside the tumors were observed on CTA images for all

  20. Mucosal surface nodularity on upper gastrointestinal series (UGIS) : prospective analysis of its primary cause and prevalence of gastric malignancy

    Energy Technology Data Exchange (ETDEWEB)

    Park, Soo Youn; Kim, Sun Mi; Kim, Ah Young; Kim, Tae Kyoung; Kim, Pyo Nyun; Ha, Hyun Kwon [Univ. of Ulsan College of Medicine, Seoul (Korea, Republic of)

    2001-10-01

    Mucosal surface nodularity was defined as present at UGIS when multiple nodular defects larger than 5 mm were scattered in the gastric mucosa in an area greater than 5 x 5 cm. The purpose of this study was to determine the primary causes of this radiographic finding and to assess the incidence of gastric malignancy in these patients. During a one-year period were prospectively collected among patients who underwent UGIS, data for 51 [aged 30-78 (mean, 51) years] above who met the criteria of mucosal surface nodularity. Whether or not this was present was decided by two radiologists who in reaching a consensus excluded the possibility of erosive gastritis, indicated by central barium collection in the nodular defects. The primary causes of mucosal nodularity and associated gastric pathologies were determined by the histopathological results obtained from the specimens after surgery (n=18) or endoscopic biopsy (n=33). Pathological examinations revealed that the primary causes of the mucosal nodularity in these 51 patients were intestinal metaplasia in 28 (54.9%), MALT lymphoma in seven (13.7%), early gastric cancer in six (11.8%), chronic gastritis in five (9.8%), low grade dysplasia in four (7.8%), and gastritis cystica profunda in one (2%). Gastric malignancy was present either in or outside the area of mucosal nodularity in 34 (66/7%) of the 51 (27 carcinomas and 7 MALT lymphomas). No different patterns of mucosal surface nodularity were noted between the groups of each disease entity. Mucosal surface nodularity is observed at UGIS in various gastric pathologies. Because of the high incidence of gastric malignancy in these patients, close follow-up or gastrofiberscopic biopsy is mandatory.

  1. The SINS trial: A randomised controlled trial of excisional surgery versus imiquimod 5% cream for nodular and superficial basal cell carcinoma

    Directory of Open Access Journals (Sweden)

    Armstrong Sarah J

    2010-04-01

    Full Text Available Abstract Background Basal cell carcinoma is the commonest human cancer. Despite increasing incidence it remains poorly researched. While not life threatening it can cause significant cosmetic disfigurement. Imiquimod, a cream which enhances the body's immune response, may help deal with the number of cases that occur in low-risk sites, especially when good cosmetic results and home use without surgery are needed. This study aims 1. To compare excisional surgery with imiquimod cream for nodular or superficial basal cell carcinoma in low risk sites, with respect to 3 year clinical clearance, cost-effectiveness and cosmetic results. 2. To ascertain if certain phenotypic features and gene polymorphisms predict tumour responsiveness to treatment. Methods/Design Five hundred participants with low risk nodular or superficial basal cell carcinoma will be recruited from hospitals to this multi-centre, randomised, parallel group, controlled phase III trial. Treatment in the imiquimod group is for 6 weeks for superficial basal cell carcinoma and 12 weeks for nodular basal cell carcinoma. Both treatment groups are followed up in clinic for 3 years. Primary outcome variable: the proportion of participants with clinical evidence of success (no recurrence at 3 years. The primary outcome will be compared between the two treatment groups. Secondary outcomes include: i clinical success at 1, 2 and 5 years, ii time to first recurrence, iii cosmetic appearance of lesion site after treatment, iv level of pain, and v cost-effectiveness. Safety and tolerability data will also be reported. Discussion This study protocol describes a pragmatic randomised controlled trial which it is hoped will address the above uncertainties. Three-year results will be available towards the end of 2010. Trial registration Meta-register: NCT00066872, Eudract No. 2004-004506-24, ISRCTN48755084.

  2. Variable uptake feature of focal nodular hyperplasia in Tc-99m phytate hepatic scintigraphy/single-photon emission computed tomography-A parametric analysis.

    Science.gov (United States)

    Hsu, Yu-Ling; Chen, Yu-Wen; Lin, Chia-Yang; Lai, Yun-Chang; Chen, Shinn-Cherng; Lin, Zu-Yau

    2015-12-01

    Tc-99m phytate hepatic scintigraphy remains the standard method for evaluating the functional features of Kupffer cells. In this study, we demonstrate the variable uptake feature of focal nodular hyperplasia (FNH) in Tc-99m phytate scintigraphy. We reviewed all patients who underwent Tc-99m phytate hepatic scintigraphy between 2008 and 2012 in Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Cases with FNH were diagnosed on the basis of pathology or at least one or more prior imaging with a periodic clinical follow-up. All patients received a standard protocol of dynamic flow study and planar and Tc-99m phytate single-photon emission computed tomography (E. CAM; Siemens). The correlation of variable nodular radioactivity with parameters such as tumor size and localization was analyzed. In total, 15 lesions of 14 patients in the clinic were diagnosed as FNH. The tumor size was approximately 2.9-7.4 cm (mean size 4.6 cm). Four lesions were larger than 5 cm. The major anatomic distribution was in the right hepatic lobe (10 lesions), particularly in the superior segments (7 lesions). Tc-99m phytate single-photon emission computed tomography imaging for determining the functional features of Kupffer cells included cool/cold (8 lesions), isoradioactive/warm (6 lesions), and hot (1 lesion) patterns of uptake. We did not observe any statistically significant correlation between variable nodular radioactivity and tumor size (p=0.68) or localization (p=0.04). Herein, we demonstrate the variable uptake feature of FNH in Tc-99m phytate scintigraphy. In small FNH tumors (< 5 cm), increased or equal uptake still provided specificity for the differential diagnosis of hepatic solid tumors.

  3. 灰质异位脑功能连接的功能磁共振成像研究%Exploring Functional Connectivity of Gray Matter Heterotopia Using fMRI

    Institute of Scientific and Technical Information of China (English)

    朱湘文; 张志强; 许强; 王正阁; 卢光明; 陈光辉; 谭启富

    2012-01-01

    目的 通过观察灰质异位脑功能连接区的空间分布形式,探索灰质异位与正常脑区间的神经功能联系.方法 研究对象为8例确诊为双侧灰质异位癫痫患者,经Siemens 3.0 T磁共振仪采集静息态及3D结构像数据.以异位灰质团块作为种子点,进行基于相关的全脑功能连接分析,并对异位灰质功能连接网络存在的模式进行观察分析.结果 (1)一侧异位灰质与对侧异位灰质存在正相关功能连接;(2)异位灰质与双侧基底神经节存在正相关连接.(3)异位灰质与正常大脑皮层存在正相关功能连接,但其空间模式与异位灰质所处的部位有关.(4)异位灰质与双侧大脑皮层也存在负相关功能连接区域,但其空间模式无明显一致性.结论 灰质异位不是孤立的异常脑结构,其不但与对侧的异位灰质保持功能连接,还与众多大脑皮层区保持着广泛的功能连接,这可能由于异位灰质团与正常皮层具有相同起源以及相似发育过程而形成的.其与基底神经节存在功能连接可能是异位灰质经常引发癫痫发作的病理生理基础之一.%Objective To study the spatial patterns of functional connectivity of heterotypic gray mailer and discuss the functional connection between lesions and normal brain regions. Methods Resting state and 3D data of 8 bilateral per ventricular nodular heterotopia (PNH) patients with epilepsy were obtained from SIEMENS Trio 3T MR scanner. Hetero-topic nodules were adopted as ROIs, which were calculated as seeds in correlative analysis, and then the functional connectivity network mode of them was observed. Results Positive correlations existed between ROIs and contralateral nodules. Some cortical regions showed functional connectivity with focal nodules, moreover, focal nodules had positive correlations with basal ganglion, and also there were negative correlations between nodules and cortex, but distributing patterns had variance

  4. TDA method application to austenite transformation in nodular cast iron with carbides assessment

    Directory of Open Access Journals (Sweden)

    G. Gumienny

    2011-07-01

    Full Text Available In this paper the possibility of TDA method using to austenite transformation in nodular cast iron with carbides assessment is presented. Studies were conducted on cast iron with about 2% molybdenum and 0,70% to 4,50% nickel. On diagrams, where TDA curves are pre- sented, on time axis a logarithmic scale was applied. It has not been used up to now. It was found, that during cooling and crystallization of cast iron in TDA probe, on the derivative curve there is a slight thermal effect from austenite to upper bainite or martensite transformation. Depending on nickel concentration austeniteupper bainite transformation start temperature changed (Bus, while MS temperature was independent of it. An influence of nickel on eutectic transformation temperature in nodular cast iron with carbides was determined too.

  5. Anxiety and depression are more prevalent in patients with graves' disease than in patients with nodular goitre

    DEFF Research Database (Denmark)

    Bové, Kira Bang; Watt, Torquil; Vogel, Asmus

    2014-01-01

    ' disease compared to patients with another chronic thyroid disease, nodular goitre, and to investigate determinants of anxiety and depression in Graves' disease.METHODS: 157 cross-sectionally sampled patients with Graves' disease, 17 newly diagnosed, 140 treated, and 251 controls with nodular goitre......' disease versus 4% in nodular goitre (p = 0.038), anxiety was 18 versus 13% (p = 0.131). Symptoms of anxiety (p = 0.04) and depression (p = 0.01) increased with comorbidity. Anxiety symptoms increased with duration of Graves' disease (p = 0.04). Neither thyroid function nor autoantibody levels were...... associated with anxiety and depression symptoms.CONCLUSIONS: Anxiety and depression symptoms were more severe in Graves' disease than in nodular goitre. Symptoms were positively correlated to comorbidity and duration of Graves' disease but neither to thyroid function nor thyroid autoimmunity....

  6. Clinical features, diagnosis, treatment and molecular studies in paediatric Cushing's syndrome due to primary nodular adrenocortical hyperplasia

    DEFF Research Database (Denmark)

    Storr, Helen L; Mitchell, J H; Swords, F M

    2004-01-01

    BACKGROUND: Primary nodular adrenocortical hyperplasia (PNAH) is a well recognized, but infrequently studied cause of paediatric Cushing's syndrome (CS). OBJECTIVE: To assess presentation, diagnosis, radiological imaging, treatment and molecular analysis of patients with childhood-onset CS due...

  7. Nodular regenerative hyperplasia, portal vein thrombosis, and avascular hip necrosis due to hyperhomocysteinaemia

    OpenAIRE

    2005-01-01

    A male patient with portal hypertension, portal vein thrombosis, spontaneous splenorenal shunt formation, and encephalopathy, thought to have post-hepatitis B cirrhosis, is described. His condition deteriorated and necessitated liver transplantation. In the explant liver, nodular regenerative hyperplasia with pronounced vascular lesions both in portal venules and in arterioles was found instead of classical cirrhosis. Two years post-transplant he developed bilateral ischaemic femur head necro...

  8. Application of Averaged Voronoi Polyhedron in the Modelling of Crystallisation of Eutectic Nodular Graphite Cast Iron

    OpenAIRE

    A. A. Burbelko; J. Początek; M. Królikowski

    2013-01-01

    The study presents a mathematical model of the crystallisation of nodular graphite cast iron. The proposed model is based on micro- andmacromodels, in which heat flow is analysed at the macro level, while micro level is used for modelling of the diffusion of elements. The use of elementary diffusion field in the shape of an averaged Voronoi polyhedron [AVP] was proposed. To determine the geometry of the averaged Voronoi polyhedron, Kolmogorov statistical theory of crystallisation was applied....

  9. Febrile cholestatic disease as an initial presentation of nodular lymphocyte-predominant Hodgkin lymphoma

    Institute of Scientific and Technical Information of China (English)

    Anna; Mrzljak; Slavko; Gasparov; Ika; Kardum-Skelin; Vesna; Colic-Cvrlje; Slobodanka; Ostojic; Kolonic

    2010-01-01

    Febrile cholestatic liver disease is an extremely unusual presentation of Hodgkin lymphoma(HL).The liver biopsy of a 40-year-old man with febrile episodes and cholestatic laboratory pattern disclosed an uncommon subtype of HL,a nodular lymphocyte-predominant HL(NLPHL).Liver involvement in the early stage of the usually indolent NLPHL's clinical course suggests an aggressiveness and unfavorable outcome.Emphasizing a liver biopsy early in the diagnostic algorithm enables accurate diagnosis and appropriate tre...

  10. Nodular lymphoid hyperplasia in the gastrointestinal tract in adult patients: A review

    Institute of Scientific and Technical Information of China (English)

    Andreia; Albuquerque

    2014-01-01

    Nodular lymphoid hyperplasia of the gastrointestinal tract is characterized by the presence of multiple small nodules, normally between between 2 and 10 mm in diameter, distributed along the small intestine(more often), stomach, large intestine, or rectum. The patho-genesis is largely unknown. It can occur in all age groups, but primarily in children and can affect adults with or without immunodeficiency. Some patients have an associated disease, namely, common variable immu-nodeficiency, selective IgA deficiency, Giardia infection, or, more rarely, human immunodeficiency virus infec-tion, celiac disease, or Helicobacter pylori infection. Nodular lymphoid hyperplasia generally presents as an asymptomatic disease, but it may cause gastrointes-tinal symptoms like abdominal pain, chronic diarrhea, bleeding or intestinal obstruction. A diagnosis is made at endoscopy or contrast barium studies and should be confirmed by histology. Its histological characteristics include markedly hyperplasic, mitotically active germi-nal centers and well-defined lymphocyte mantles found in the lamina propria and/or in the superficial submu-cosa, distributed in a diffuse or focal form. Treatment is directed towards associated conditions because the disorder itself generally requires no intervention. Nodu-lar lymphoid hyperplasia is a risk factor for both intes-tinal and, very rarely, extraintestinal lymphoma. Someauthors recommend surveillance, however, the duration and intervals are undefined.

  11. Epitheloid hemangioma: A report of two cases

    Directory of Open Access Journals (Sweden)

    Basanti Devi

    2014-01-01

    Full Text Available We report two cases of epitheloid hemangioma presented with multiple nodular lesions over head and neck region. One of them gave history of bleeding on minor trauma. Pyogenic granuloma was considered as a differential diagnosis from the morphological appearance and history of bleeding. Nodular leprosy, sarcoidosis, and secondary syphilis were also considered. Histopathological examination of both was typical of epitheloid hemangioma, an entity commonly overlooked clinically due to its rarity.

  12. 儿童结节性胃炎幽门螺杆菌耐药性分析%Drug resistance of Helicobacter pylori in nodular gastritis in children

    Institute of Scientific and Technical Information of China (English)

    王玉环; 黄瑛; 王传清; 吴婕

    2014-01-01

    Objective To analyze the drug resistance of Helicobacter pylori (H.pylori) in nodular gastritis in children and to further explore the rational use of antibiotics for drug-resistant H.pylori strains. Methods A total of 473 children with upper gastrointestinal symptoms undergoing gastroscopy from January 2013 to June 2014 in our hospital were enrolled. Two pieces of gastric antral mucosa in children with nodular gastritis were collected for H.pylori rapid urease test and H.pylori culture. The resistance of H.pylori to amoxicillin, clarithromycin, metronidazole, moxilfoxacin and levolfoxacin was detected by agar dilution method and E-test. Results In 473 cases of nodular gastritis, 258 cases were H.pylori culture-positive. The resistance rate of H. pylori isolates to amoxicillin, clarithromycin, metronidazole, moxilfoxacin, levolfoxacin was 6.2%, 34.9%, 49.2%, 8.9%and 5.0%, respectively. Dual resistance to clarithromycin and metronidazole was 23.3%. Moreover, 405 cases had a family history of H.pylori infection. Conclusions Nodular gastritis is a special sign of H.pylori infection in children. H.pylori infection has obvious familial aggregation. The low resistance rate of H.pylori to amoxicillin in children with nodular gastritis indicates that amoxicillin can be used as the main drug for eradication of H.pylori. Meanwhile, clarithromycin should be applied according to the drug sensitive test due to high resistance rate of H.pylori to clarithromycin.%目的:分析儿童结节性胃炎幽门螺杆菌(H.pylori)的耐药情况,探讨H.pylori耐药菌株的抗生素合理使用方法。方法2013年1月至2014年6月因上消化道症状就诊行胃镜检查的结节性胃炎患儿473例,收集患儿的胃窦黏膜2块,分别行H.pylori快速尿素酶试验和培养。用琼脂稀释法和E-test法检测H.pylori对阿莫西林、克拉霉素、甲硝唑、莫西沙星和左氧氟沙星的耐药情况。结果473例结节性胃炎患儿,258例H.pylori培养阳

  13. Panniculitis caused by Mycobacterium monacense mimicking erythema induratum: a case in Ecuador.

    Science.gov (United States)

    Romero, J J; Herrera, P; Cartelle, M; Barba, P; Tello, S; Zurita, J

    2016-03-01

    We report the first case of recently characterized species M. monacense associated with chronic nodular vasculitis, infecting a young woman. This case represents the first isolation of M. monacense from Ecuador. The isolate was identified by conventional and molecular techniques.

  14. Panniculitis caused by Mycobacterium monacense mimicking erythema induratum: a case in Ecuador

    OpenAIRE

    Romero, J.J.; Herrera, P.; Cartelle, M.; Barba, P.; Tello, S.; ZURITA, J.

    2016-01-01

    We report the first case of recently characterized species M. monacense associated with chronic nodular vasculitis, infecting a young woman. This case represents the first isolation of M. monacense from Ecuador. The isolate was identified by conventional and molecular techniques.

  15. Clinical study of multi nodular goitre in a rural hospital

    Directory of Open Access Journals (Sweden)

    C. Stalin Raja

    2014-08-01

    Methods: This was a prospective study of 50 cases of MNG during the period between April 2012 and March 2014, in Chennai medical college hospital with an adequate follow up to look for post op complications. Results: Majority of the patients were females with an M:F ratio of 15:1,with the commonest age group being 31-40 years. All patients presented with swelling in front of the neck, with other complaints being that of pain, discomfort, and features of hyperthyroidism in 6 patients. FNAC was done in all patients and was found to be 100% accurate. Majority of the patients were treated with total thyroidectomy followed by subtotal thyroidectomy. Complications included wound infection, post op bleeding and RLN palsy. Conclusion: FNAC is an invaluable and highly accurate tool in the diagnosis of MNG. Surgery - Total thyroidectomy was found to be an adequate and safe treatment for non- toxic MNG with minimal complications. [Int J Res Med Sci 2014; 2(4.000: 1350-1354

  16. Lesión nodular de mama de crecimiento rápido A Nodular and Fast Growing Breast Mass

    Directory of Open Access Journals (Sweden)

    Gerardo Sáenz-Batalla

    2008-09-01

    Full Text Available La hiperplasia estromal seudoangiomatosa es un hallazgo histológico benigno, relativamente infrecuente, caracterizada por aumento de la densidad mamaria, proliferación de fibras colágeno y del estroma que forma pseudoespacios capilares vacíos anastomosados entre sí. La etiología no es clara, pero tiene una marcada influencia hormonal. Tanto clínica como radiológicamente puede semejar lesiones benignas y malignas. La histología es fundamental para hacer el diagnóstico definitivo. Se reporta el caso clínico de una mujer herediana de 40 años con una masa mamaria derecha, deformante, asimétrica, de crecimiento rápido, dolorosa y multirecidivante, que finalmente resolvió con una mastectomía subcutánea.Pseudoangiomatous stromal hyperplasia of the breast is a rare benign disease, which was described by Vuitch in 1986. The etiology is not clear, but an hormonal influence has been demonstrated. To confirm the diagnosis, a biopsy is required primarily to distinguish a malignant disease like low grade angyosarcoma, a fibroadenoma or a Philloides tumor; these entities are similar in their clinical and imaging features. We present herein the case of a 40 year old female that presented with a fast growing, painful, recurrent breast mass, initially treated as fibrocystic breast disease but the histopathology later demonstrated the lesion to be a pseudoangiomatous stromal hyperplasia, which is very infrequent. Finally she underwent a sucutaneuos mastectomy, and the diagnosis was again confirmed. An extensive review of current literature confirmed that mastectomy is better, especially in cases with diffuse and recurrent tumors.

  17. Immunoarchitectural patterns of progressive transformation of germinal centers with and without nodular lymphocyte-predominant Hodgkin lymphoma.

    Science.gov (United States)

    Hartmann, Sylvia; Winkelmann, Ria; Metcalf, Ryan A; Treetipsatit, Jitsupa; Warnke, Roger A; Natkunam, Yasodha; Hansmann, Martin-Leo

    2015-11-01

    Progressive transformation of germinal centers (PTGC) has been frequently described in association with Hodgkin lymphoma, particularly nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). The aim of this study was to evaluate morphologic features of PTGC for better delineation of PTGC from early involvement by NLPHL. A total of 160 cases of PTGC were evaluated and included in the following 3 groups: 93 patients with PTGC who never developed a lymphoma, 23 patients with synchronous PTGC and NLPHL, and 44 patients with PTGC with antecedent or subsequent history of lymphoma. By histopathologic evaluation, 5 patterns of PTGC that reflected progressive dismantling of germinal centers were identified. There was no difference in the distribution of patterns 1 to 4 among the 3 groups of PTGC; however, in patients showing synchronous involvement of PTGC and NLPHL, pattern 5, which resembles a naïve B-cell follicle, was significantly more frequently observed (14/23) when compared with patients with PTGC who never developed a lymphoma (30/93; P = .0161). Furthermore, recognition of the spectrum of immunoarchitectural patterns of PTGC, including architectural and cytologic features, was helpful to better differentiate nodules involved by PTGC from NLPHL.

  18. 预防PICC置管时异位入颈内静脉的改进方法%The improvement method of preventing PICC catheter heterotopia into the internal jugular vein

    Institute of Scientific and Technical Information of China (English)

    黎逢弟; 陈其欣; 练国香; 梁红梅

    2015-01-01

    Objective:To explore the effective method of preventing tube ectopic into the internal jugular vein for Peripherally inserted central catheters ( PICC) . Methods:160 patients with PICC were randomly divided into the control group and experimental group,80 cases of each group. In the control group,a position of 90° abduction was adopted between upper limb and the trunk,when the catheter tip reached the shoulders,the patients were turned over with their heads to the side. While in the experimental group,the catheter was shaping before intubation,and the patients raise their arms and close the heads to the upper limbs when the catheter tip reached the shoulders. After catheter,the comparison was made with the incidence of catheter ectopic. Results:The incidence of catheter heterotopia in experimental group was significantly lower than that of the control group (P<0. 05). Conclusion:It can reduce the inci-dence of heterotopia into the internal jugular vein catheter with shaping the catheter before intubation,and raise the patients′arms and close their heads to the upper limbs when the catheter tip reached the shoulders. It is worthy of clinical application.%目的::探讨经外周置入中心静脉导管( PICC)置管时预防导管异位入颈内静脉的有效方法。方法:将2012年10月~2014年3月我院160例行PICC置管患者随机等分为对照组和试验组,对照组采用常规的患者上肢外展与躯干呈90°体位,当导管头端到达肩部时采用偏头法;试验组送管前对导管进行塑形、当导管头端送至肩峰时再采用举臂贴头体位。置管后比较导管异位入颈内静脉的发生率。结果:试验组导管异位入颈内静脉的发生率明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论:在PICC置管时采用对导管塑形和举臂贴头法能明显降低导管异位入颈内静脉的发生率,值得临床推广应用。

  19. [The morphology and differential diagnosis of neuroglial heterotopias and related tumors].

    Science.gov (United States)

    Shelekhova, K V; Sokolova, I A; Kazakov, D V; Michal, M

    2009-01-01

    The paper reviews the data available in the literature and a clinicomorphological analysis of 15 cases of neuroglial heteropias and related tumors retrieved from the joint databases of Sikl's Department of Pathology, Pilsen, Czech Republic, and the Department of Pathology, Petrov Oncology Institute, with emphasis on the histological, immunohistochemical and ultrastructural features, as well as differential diagnosis.

  20. Cellular Automaton Simulation For Volume Changes Of Solidifying Nodular Cast Iron

    Directory of Open Access Journals (Sweden)

    Burbelko A.

    2015-09-01

    Full Text Available Volume changes of the binary Fe-C alloy with nodular graphite were forecast by means of the Cellular Automaton Finite Differences (CA-FD model of solidification. Simulations were performed in 2D space for differing carbon content. Dependences of phase density on temperature were considered in the computations; additionally density of the liquid phase and austenite were deemed as a function of carbon concentration. Changes of the specific volume were forecast on the base of the phase volume fractions and changes of phase density. Density of modeled material was calculated as weighted average of densities of each phase.

  1. Giant benign nodular hidradenoma of the shoulder: A rare tumor in orthopedic practice

    Directory of Open Access Journals (Sweden)

    Singhal Vibhore

    2010-01-01

    Full Text Available A clear cell hidradenoma is a rare dermal tumor, which is believed to originate from the apical portion of the sweat glands. The usual size reported is 5-30 mm. It is generally found in the head, face, and upper extremity regions. This lesion has not been reported to be large enough to impinge a joint range of motion. Hence, its description in the orthopedic literature is extremely rare. We present a giant benign nodular hidradenoma presenting as painful restriction of the right shoulder joint in a 35-year-old male.

  2. Centrifugal Casting of High Speed Steel/Nodular Cast Iron Compound Roll Collar

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The centrifugal casting of compound HSS/nodular cast iron roll collar was studied, and the factors affecting transition zone quality were analyzed. The pouring temperature and interval in pouring are the main factors affecting transition zone quality. By controlling process parameter and flux adding during casting, high quality roll collar was obtained. The cause, why in the casting of HSS part, segregation appears easily, was analyzed and the countermeasure eliminating segregation was put forward, the measure eliminating heat treatment crackling was also put forward.

  3. Nodular vasculitis%结节性血管炎的研究进展

    Institute of Scientific and Technical Information of China (English)

    刘伟军; 王洪生

    2013-01-01

    Nodular vasculitis and erythema induratum have similar clinical and pathological manifestations.No definitive conclusion has been made on whether they are the same entity.It is generally acknowledged that erythema induratum is equated to nodular vasculitis when tuberculosis infection is present.Nodular vasculitis should be highly suspected in middle-aged women with crops of recurrent and painful violaceous nodules or plaques in posterior legs.The exact etiology is unknown.It was once thought to be caused by tuberculosis only,but now is believed to be likely associated with chlamydial infection,streptococcal infection,autoimmune diseases,cancer,and so on.Lobular panniculitis appears to be the most common histopathological manifestation.It is important for the treatment of nodular vasculitis to find out the potential cause as far as possible.Therapeutic agents include potassium iodide,glucocorticoids,non-steroidal antiinflammatory drugs,and so on.%结节性血管炎和硬红斑在临床和病理上相似,是否和硬红斑为同一疾病尚无定论,目前认为,结节性血管炎找到结核杆菌感染的证据即为硬红斑.临床上中年女性下肢尤其是小腿后侧的疼痛性复发性紫红色结节或斑块,应高度怀疑本病.确切病因不明,曾认为是结核感染引起,目前推测可能与结核、衣原体、链球菌等感染、自身免疫性疾病、肿瘤等都有一定联系.多数患者的组织病理显示为小叶性脂膜炎.治疗上应尽可能找出潜在的病因,治疗的药物有碘化钾、糖皮质激素、非甾体抗炎药等.

  4. Embrittlement of austempered nodular irons: Grain boundary phosphorus enrichment resulting from precipitate decomposition

    Science.gov (United States)

    Klug, R. C.; Hintz, M. B.; Rundman, K. B.

    1985-05-01

    The microstructures, mechanical properties, and fracture behavior were characterized for a series of Mg treated nodular cast iron specimens austenitized at 1170, 1255, and 1340 K and subsequently austempered at 640 K. The ductility and toughness of the alloy decreased as austenitization temperatures were increased, which is contrary to the behavior anticipated from the observed micro-structural evolution. Fractographic and surface chemical analyses demonstrated that the mechanical property degradation was associated with embrittlement of the austenite grain boundaries by phosphorus. The primary mechanism of grain boundary phosphorus enrichment does not appear to be equilibrium segregation, and an alternative mechanism based on the decomposition of P rich precipitates is proposed and discussed.

  5. A report of 7 cases wiht pancreatic heterotopia%异位胰腺七例报告

    Institute of Scientific and Technical Information of China (English)

    施红旗; 张启瑜; 陈吉彩

    2000-01-01

    目的:探讨异位胰腺的临床特点、诊断及外科处理原则.临床资料:7例异位胰腺患者,其中异位胰腺分布于十二指肠4例、空肠2 例、胃1例.临床表现为腹痛4例、黄疸3例、十二指肠梗阻1例、消化道出血1例;合并胆石病3例、空肠憩室1例.7例术前均被漏、误诊,均行手术治疗并经病理确诊. 结论:异位胰腺临床表现无特异性,术前诊断困难,易被漏、误诊,一经诊断,不论有无症状,均以手术治疗为宜,以便明确诊断和防止发生并发症.

  6. Salivary gland choristoma in the buccinator muscle: A case report and literature review

    Science.gov (United States)

    Sotorra-Figuerola, Dídac; Almendros-Marqués, Nieves; Espana-Tost, Antonio-Jesús; Valmaseda-Castellón, Eduard; Gay-Escoda, Cosme

    2015-01-01

    Salivary gland choristoma (SGCh) is defined as the presence of normal salivary tissue in an abnormal location. It is a rare entity in oral and maxillofacial region and its ethiology is unknown. The typical presentation of salivary gland heterotopia is an asymptomatic mass that may or may not produce saliva. Some examples of ectopic salivary tissue in the pituitary gland, in the lymph nodes, in the middle ear, in the neck, in the jaw, in the thyroid gland, in the mediastinum and in the rectum have been documented in literature. We report the case of a 61-year-old male presented with a bilateral tumorlike mass in the cheek. The mass was painless, of fibrous consistency and had size change with time. The histological diagnosis was salivary gland choristoma in the buccinator muscle. In this article, we will revise the characteristic of salivary gland heterotopias and we present a report case that has not been described in literature: a bilateral choristoma of salivary gland in the buccinator muscle, which should be included in the differential diagnosis of head and neck masses. Key words:Choristoma, heterotopias, ectopic tissue, salivary gland, buccinator muscle. PMID:26535104

  7. Focal nodular hyperplasia and hepatocellular adenoma; Fokale nodulaere Hyperplasie und hepatozellulaeres Adenom

    Energy Technology Data Exchange (ETDEWEB)

    Bastati-Huber, N.; Poetter-Lang, S.; Ba-Ssalamah, A. [Medizinische Universitaet Wien, Universitaetsklinik fuer Radiologie und Nuklearmedizin, Abteilung fuer Allgemeine Radiologie und Kinderradiologie, Department of Biomedical Imaging and Image-guided Therapy, Wien (Austria)

    2015-01-01

    Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) are liver lesions of hepatocellular origin. The FNH is a commonly occurring hepatic lesion whereas HCA is very rare. Non-invasive differentiation between HCA subtypes and atypical FNH may pose a diagnostic challenge as both entities predominantly occur in middle-aged female patients. The conventional imaging modalities include ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI). Distinguishing FNH from HCA is of great importance clinically as FNH is considered to be a benign lesion and needs no further management. In contrast HCA is considered to be a borderline tumor due to the risk of hemorrhage, growth and even malignant transformation and requires individualized management. The abovementioned radiological procedures usually enable an accurate and certain diagnosis of a typical FNH to be achieved. In cases of atypical FNH, particularly in patients with a clinical history of malignancy, these imaging modalities are insufficient to establish a clear diagnosis. In this scenario, the use of modern hepatobiliary contrast-enhanced MRI will enable a differentiation between FNH and metastasis with a high sensitivity and specificity. Furthermore, it allows a differentiation of FNH from 90 % of adenoma subtypes. This article describes the histopathological and radiological features of these lesions and explains the advantages and limitations of various imaging modalities used for the diagnosis and differentiation of these entities. The new classification of HCAs according to phenotype and genotype and their imaging features, as well as different enhancement patterns, are described. The correlation between HCA subtypes and their individual management are also discussed. (orig.) [German] Die fokale nodulaere Hyperplasie (FNH) und das hepatozellulaere Adenom (HCA) sind Leberlaesionen hepatozellulaeren Ursprungs. Die FNH ist eine sehr haeufige, das HCA eine sehr seltene Leberlaesion

  8. Quality-of-Life Impairments Persist Six Months After Treatment of Graves' Hyperthyroidism and Toxic Nodular Goiter

    DEFF Research Database (Denmark)

    Cramon, Per; Winther, Kristian Hillert; Watt, Torquil

    2016-01-01

    PRO scales in toxic nodular goiter (Anxiety, Overall HRQoL). However, significant disease-specific and generic HRQoL deficits persisted on multiple domains across both patient groups. Conclusions: Graves' hyperthyroidism and toxic nodular goiter cause severe disease-specific and generic HRQoL impairments......Background: The treatment of hyperthyroidism is aimed at improving health-related quality of life (HRQoL) and reducing morbidity and mortality. However, few studies have used validated questionnaires to assess HRQoL prospectively in such patients. The purpose of this study was to assess the impact...... of hyperthyroidism and its treatment on HRQoL using validated disease-specific and generic questionnaires. Methods: This prospective cohort study enrolled 88 patients with Graves' hyperthyroidism and 68 with toxic nodular goiter from endocrine outpatient clinics at two Danish university hospitals. The patients were...

  9. Standard test method for determining nodularity and nodule count in ductile iron using image analysis

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2011-01-01

    1.1 This test method is used to determine the percent nodularity and the nodule count per unit area (that is, number of nodules per mm2) using a light microscopical image of graphite in nodular cast iron. Images generated by other devices, such as a scanning electron microscope, are not specifically addressed, but can be utilized if the system is calibrated in both x and y directions. 1.2 Measurement of secondary or temper carbon in other types of cast iron, for example, malleable cast iron or in graphitic tool steels, is not specifically included in this standard because of the different graphite shapes and sizes inherent to such grades 1.3 This standard deals only with the recommended test method and nothing in it should be construed as defining or establishing limits of acceptability or fitness for purpose of the material tested. 1.4 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard. 1.5 This standard does not purport to address al...

  10. Strength distribution at interface of rotary-friction-welded aluminum to nodular cast iron

    Institute of Scientific and Technical Information of China (English)

    SONG Yu-lai; LIU Yao-hui; ZHU Xian-yong; YU Si-rong; ZHANG Ying-bo

    2008-01-01

    The morphology, size and composition of intermetallic compound at the interface of Al 1050 and nodular cast iron were studied by electron microprobe analysis(EMPA) and scan electron microscopy (SEM), respectively. The bond strength of the interface was measured by the tensile tests and the morphology of the fracture surface was observed by SEM. The observation of the interface reveals that there are two distinct morphologies: no intermetallic compound exists in the central area at the interface; while numbers of intermetallic compounds (FexAly) are formed in the peripheral area due to the overfull heat input. The tensile tests indicate that the distribution of strength in radial direction at the interface is inhomogeneous, and the central area of the interface performs greater bond strength than the peripheral area, which proves directly that the FexAly intermetallic compounds have a negative effect on the integration of interface. The morphology on the fracture surface shows that the facture in the central area at the interface has characteristic of the ductile micro-void facture. So it is important to restrain the form of the intermetallic compound to increase the bond strength of the Al 1050 and nodular cast iron by optimizing welding parameters and the geometry of components.

  11. Human immunodeficiency virus and nodular regenerative hyperplasia of liver: A systematic review

    Institute of Scientific and Technical Information of China (English)

    Archita; Sood; Mariana; Castrejón; Sammy; Saab

    2014-01-01

    AIM: To investigate the diagnosis, pathogenesis, natural history, and management of nodular regenerative hyperplasia(NRH) in patients with human immunodeficiency virus(HIV). METHODS: We performed a systematic review of the medical literature regarding NRH in patients with HIV. Inclusion criteria include reports with biopsy proven NRH. We studied the clinical features of NRH, in particular, related to its presenting manifestation and laboratory values. Combinations of the following keywords were implemented: "nodular regenerative hyperplasia", "human immunodeficiency virus", "noncirrhotic portal hypertension", "idiopathic portal hypertension", "cryptogenic liver disease", "highly active antiretroviral therapy" and "didanosine". The bibliographies of these studies were subsequently searched for any additional relevant publications.RESULTS: The clinical presentation of patients with NRH varies from patients being completely asymptomatic to the development of portal hypertension – namely esophageal variceal bleeding and ascites. Liver associated enzymes are generally normal and synthetic function well preserved. There is a strong association between the occurrence of NRH and the use of antiviral therapies such as didanosine. The management of NRH revolves around treating the manifestations of portal hypertension. The prognosis of NRH is generally good since liver function is preserved. A high index of suspicion is required to make a identify NRH. CONCLUSION: The appropriate management of HIVinfected persons with suspected NRH is yet to be outlined. However, NRH is a clinically subtle condition that is difficult to diagnose, and it is important to be able to manage it according to the best available evidence.

  12. Mucinous versus nonmucinous solitary pulmonary nodular bronchioloalveolar carcinoma: CT and FDG PET findings and pathologic comparisons.

    Science.gov (United States)

    Lee, Ho Yun; Lee, Kyung Soo; Han, Joungho; Kim, Byung-Tae; Cho, Young-Seok; Shim, Young Mog; Kim, Jhingook

    2009-08-01

    We aimed to evaluate the CT, PET, and pathologic findings of solitary pulmonary nodular mucinous and nonmucinous bronchioloalveolar carcinomas (BACs). From August 2003 to March 2008, we saw 24 patients with solitary pulmonary nodular mucinous (n=6) or nonmucinous (n=18) BACs that were resected. CT and PET findings of the lesions were assessed in terms of size, solidity, morphologic characteristics, attenuation and maximum standardized uptake value (mSUV). All nonmucinous BACs appeared as a pure ground-glass opacity (GGO) nodule, whereas mucinous BACs appeared as solid (n=4) or part-solid (n=2) nodules. CT attenuation values were significantly higher for mucinous BACs (-21.0 HU+/-4.9) than for nonmucinous BACs (-491.8 HU+/-172.5) (PBACs and 0.5+/-0.8 for nonmucinous BACs (P=.007), but mSUVs were not statistically different after size adjustment (r=0.371, P=.081). Mucinous BACs appear as solid or part-solid nodules at CT, whereas nonmucinous BACs present as pure GGO nodules. Both subtypes of tumors show scant FDG uptake at PET.

  13. Nodular lymphoid hyperplasia of the colon in a vervet monkey (Cholorocebous aethiops).

    Science.gov (United States)

    Hablolvarid, M H

    2014-12-01

    Diffuse nodular lymphoid hyperplasia (DNLH) of gastrointestinal tract is regarded as a very rare disease in the adult population. It is characterized by presence of diffuse detectable small polypoid masses distributed in the small intestine, colon, or both. A 6-year-old male in captivity suddenly died, due to myocardial infarction. During routine necropsy procedure, incidentally, numerous tan, sessile polyps, up to 0.2 cm were noticed in all segments of the colon. Histopathological and immunohistochemical examination revealed polypoid masses as nodular lymphoid hyperplasia (NLH), comparable with DNLH of the colon in human. In this article, the author has tried to introduce some immunosuppresive (e.g., simian retrovirus type D (SRV), simian immunodeficiency virus (SIV)) and opportunistic viruses (e.g., lymphocryptovirus, γ-herpesvirus, adenovirus), as well as, primary and opportunistic bacteria (e.g., Yersinia psedotuberculosis, and Helicobacter spp.) that may trigger benign reactive process, lymphoid hyperplasia, in non-human primates (NHPs) in captivity. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  14. Sentinel lymph node biopsy: is it possible to reduce false negative rates by excluding patients with nodular melanoma?

    LENUS (Irish Health Repository)

    Corrigan, M A

    2012-02-03

    OBJECTIVE: The aim of this study was to review the outcome of sentinel lymph node biopsy (SLNB) in patients with melanoma and to delineate whether patients with nodular melanoma are more likely to develop nodal recurrence despite negative SLNB. METHODS: Consecutive patients with cutaneous melanoma undergoing SLNB were identified from a departmental database between 1997 and 2005. Factors including demographic data, site, histological subtype, depth and outcome were examined. RESULTS: Of 131 patients, 103 were node negative and eligible for study. The median age was 53 (16-82) years with 46 patients being male (45%) and 57 female (55%). Primary melanoma sites included lower limb (49; 48%), upper limb (29; 28%), head (12; 11%), trunk (7; 7%) and back (6; 6%). The median Breslow thickness was 2mm. Superficial spreading accounted for 43% of melanoma with nodular accounting for 42%. Median follow-up was 40 (3-90) months. Of 20 relapses, seven recurred in the same nodal basin, three were satellite recurrences, one recurred with both satellite and nodal lesions simultaneously, and nine experienced haematogenous spread. Of the eight patients who developed recurrence in the same nodal basin, four were of nodular histological subtype (p=NS). All of the three patients with satellite lesions had nodular melanoma histologically (p=0.02). When nodal and satellite recurrences were combined, eight of 11 were histologically nodular (p=0.01). CONCLUSIONS: This study indicates that lymphatic recurrence occurs more often in SLNB negative patients with nodular melanoma. Further evaluation of the inclusion criteria for sentinel node biopsy is warranted.

  15. Adaptación de tecnología en la fabricación de fundiciones nodulares

    Directory of Open Access Journals (Sweden)

    Héctor Mosquera Mosquera

    2012-05-01

    Full Text Available La producción de fundiciones nodulares de manera competitiva y económica, exige del conocimiento a fonda de las variables implicadas en el proceso; lo cual permite obtener la amplia gama de propiedades que reúne este grupo de aleaciones. En este documento se presentan los resultados y conclusiones alcanzados, al hacer algunas modificaciones en las variables de los procesos de fabricación. Además, se muestra el horno de cubilote como una alternativa al alcance de la pequeña y la mediana industria para la producción económica de fundiciones nodulares.

  16. Significado prognóstico dos graus histológicos do linfoma de Hodgkin do tipo esclerose nodular Prognostic significance of histopathological grading of nodular sclerosing Hodgkin’s lymphoma

    Directory of Open Access Journals (Sweden)

    Luís Fernando Pracchia

    2005-10-01

    Full Text Available INTRODUÇÃO: A esclerose nodular (EN, do tipo histológico freqüente do linfoma de Hodgkin (LH, apresenta grande variabilidade em sua composição celular. Na década de 80, pesquisadores do British National Lymphoma Investigation (BNLI propuseram uma subclassificação histológica do LH EN. Eles identificaram dois graus histológicos - o LH EN grau I (LH EN I e o LH EN grau II (LH EN II - e demonstraram que os portadores de LH EN II apresentavam menor sobrevida em comparação aos portadores de LH EN I. Outros estudos, entretanto, não reproduziram esses achados. OBJETIVO: Avaliar o significado prognóstico da graduação histológica proposta pelo BNLI. MATERIAIS E MÉTODOS: Estudo retrospectivo que incluiu 69 casos de LH EN. Mais de 90% dos casos foram tratados com terapia combinada ou quimioterapia exclusiva, não havendo diferença no tipo de tratamento oferecido a depender do grau histológico. RESULTADOS: Trinta e cinco casos (51% foram classificados com EN I e 34 (49% como EN II. Não observamos diferenças na distribuição de outros fatores prognósticos entre os portadores dos dois graus. Remissão completa após o tratamento inicial foi obtida em 85,7% dos casos de EN I e em 82,4% dos casos de EN II (p = 0,75. A probabilidade estimada de sobrevida global em cinco anos foi de 67% para EN I e de 83,5% para EN II (p = 0,13 e a taxa de sobrevida livre de doença em cinco anos foi de 85,2% versus 87%, respectivamente (p = 0,72. CONCLUSÃO: Nesta população de pacientes uniformemente tratados a graduação histológica BNLI não esteve associada com o prognóstico do LH EN.BACKGROUND: Nodular sclerosis (NS, a frequent histological subtype of Hodgkin’s lymphoma (HL, presents great variability in its cellular composition. In the 80's, researchers of the British National Lymphoma Investigation (BNLI proposed a histological-based subclassification for NS HL. They identified two histological grades - NS HL grade I (NS HL I and NS HL grade

  17. Rapidly-Growing Nodular Pseudoangiomatous Stromal Hyperplasia of the Breast: Case Report

    OpenAIRE

    Nuket ELİYATKIN; Karasu, Başak; Elif SELEK; Yavuz KEÇECİ; POSTACI, Hakan

    2011-01-01

    Pseudoangiomatous stromal hyperplasia is a benign proliferative lesion of the mammary stroma that rarely presents as a localized mass. Pseudoangiomatous stromal hyperplasia is characterized by a dense, collagenous proliferation of the mammary stroma, associated with capillary-like spaces. Pseudoangiomatous stromal hyperplasia can be mistaken with fibroadenoma on radiological examination or with low-grade angiosarcoma on histological examination. Its main importance is its distinction from ang...

  18. Sclerosing angiomatoid nodular transformation of the spleen presenting rapid growth after adrenalectomy: Report of a case

    Directory of Open Access Journals (Sweden)

    Yasuo Nagai

    2017-01-01

    Conclusion: Decreases in glucocorticoid concentrations following adrenalectomy may have contributed to the rapid growth of SANT of the spleen, because SANT is considered to be related to immunoglobulin G4-associated disease.

  19. Programa nacional de bocio nodular (PRONBONO: Estudio multicéntrico de bocio nodular único palpable National Program for Nodular Goiter (PRONBONO: Multicenter study of single palpable thyroid nodules

    Directory of Open Access Journals (Sweden)

    M. Corino

    2011-09-01

    Full Text Available Introducción: La presencia de nódulos tiroideos palpables en la población general, es uno de los signos clínicos tiroideos más frecuentes en la práctica diaria. Objetivos: 1 establecer la prevalencia de las distintas patologías en bocio nodular único palpable y analizar sus características y su relación con los resultados citológicos. 2 analizar la existencia de diferencias regionales en Argentina. Pacientes y Métodos: Estudio prospectivo de 739 pacientes con bocio nodular único palpable evaluados entre el 1/1/2000 y el 31/12/2001 en Centros de Buenos Aires, Bahía Blanca, Mendoza y La Pampa. Se recabaron datos de examen clínico, ecografía tiroidea, TSH, ATPO y citología por punción con aguja fina. (PAAF. Fue utilizado para el análisis estadístico Correlación de Pearson, X2 y Test de Fisher. Resultados: la edad (X ± DS fue 46,3 ± 14 años, 93,1 % eran de sexo femenino. El 1,6 % tenía historia de radiación en cuello y el 29,9 % antecedentes familiares de patología tiroidea. Hallazgos clínicos: disfagia en el 7,9 %, disfonía 3,5 %, crecimiento nodular en los últimos 6 meses 19,2 %, consistencia dura el 24,7 %, fijeza a estructuras adyacentes 1,5 % y adenopatías en el 3 %. Hallazgos bioquímicos: TSH normal en el 81,2 % y ATPO positivos en el 30,3 % de los casos. Características Ecográficas: nódulos sólidos: 53,1 %, hipoecoicos: 63,8 %, microcalcificaciones 10,3 %, halo incompleto: 15 %, multinodular: 30,5 %, tiroides heterogénea: 60,2 % y adenopatías: 3,8 %. Hallazgos citológicos: En el 86,8 % de los casos fue necesario solo una punción para llegar al diagnóstico. Insatisfactorio (excluyendo quiste: 3,2 %: benignos: 77,3 %; sospechosos: 12,6 % y cáncer: 7 % (42 papilar, 2 medular y 3 sin especificar. Una correlación significativa (pIntroduction: the presence of palpable thyroid nodules in the general population is one of the most common clinical signs of thyroid disease in daily practice. Objectives: 1 To

  20. Comprehensive Application of 64-slice Spiral CT Scan Techniques on Diagnosis Value of Nodular Goiter%64排CT的综合运用对诊断结节性甲状腺肿价值探讨

    Institute of Scientific and Technical Information of China (English)

    肖继伟; 王晓燕; 胡道予

    2014-01-01

    目的:探讨64排螺旋CT扫描技术的综合运用对结节性甲状腺肿的诊断及鉴别诊断方面的价值。方法:选择41例经过病理证实的结节性甲状腺肿,甲状腺肿瘤及其他结节性甲状腺疾病若干,全部行64排螺旋CT平扫及动态增强扫描加后续重建,观察病灶的大小、形态、密度、边缘、强化特点及有无侵犯和转移等,总结和归纳病灶的影像学表象及特征。结果:结节性甲状腺肿、甲状腺肿瘤及其他结节性甲状腺疾病在CT影像上的表现可能少部分有所重叠,但大多数趋于不同,且有一定规律可循。结论:基于64排CT扫描技术的综合运用可在很大程度上掌握结节性甲状腺肿及相似疾病的表象及特征,对结节性甲状腺肿诊断及鉴别诊断具有重要意义。%Objective:To discuss the comprehensive application of 64-slice spiral CT scan techniques on the diagnosis value of nodular goiter and its differential diagnostic value. Methods:41 cases of nodular goiter,thyroid tumors and other nodular thyroid diseases,which had been verified by pathology,were selected to conduct 64-slice spiral CT scan and dynamic contrast-enhanced scan plus follow-up reconstruction. With observing the size,shape,density,edge,enhancing char-acteristics of the lesion as well as its infringement and metastasis,imaging characteristics of the le-sion were concluded. Results:The imaging manifestations of nodular goiter,thyroid tumors and oth-er nodular thyroid diseases overlap only in small portion on CT,but mostly they are different. Con-clusion:The comprehensive application of 64-slice spiral CT scan techniques can considerably di-agnose the representations and characteristics of nodular goiter and similar diseases,which is signifi-cant to the diagnosis and differential diagnosis of nodular goiter.

  1. MR Imaging Features of a Solitary Subcutaneous Metastasis from a Gastric Adenocarcinoma: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jung Im; Choi, Jung Ah; Choi, Ja Young; Hong, Sung Hwan; Kang, Heung Sik [Seoul National University, Seoul (Korea, Republic of); Chung, Jin Haeng; Oh, Joo Han [Seoul National University Bundang Hospital, Seungnam (Korea, Republic of)

    2009-03-15

    Subcutaneous tissue is an unusual site for a metastasis from a gastric carcinoma. We present a case of a patient with a nodular solitary subcutaneous metastasis from a gastric cancer and describe its magnetic resonance imaging (MRI) features

  2. Effects of Cr Content and Annealing Temperature on Microstructure and Wear Characteristics of Cast Ausferrite Nodular Iron

    Institute of Scientific and Technical Information of China (English)

    Jia-peng ZOU; Kazumichi SHIMIZU; Qi-zhou CAI

    2015-01-01

    The effects of Cr content and annealing temperature on abrasive wear characteristics of cast ausferrite nodular iron were investigated with Suga type abrasive wear tester. The surface morphology and Vickers hardness of the tested samples were analyzed by scanning electron microscopy (SEM), digital microscope and Vickers hardness tester. The results show that the cast ausferrite nodular iron could be obtained by alloying with Cr in the as-cast ductile cast iron and permanent mold casting, and the bainite con-tent in the matrix increased with increasing Cr content. However, the decomposition of bainite took place during annealing at 500 °C to 800 °C; especially, at 800 °C, the bainite transformed into a mixture of ifne lamellar pearlite and ferrite matrix structure. The wear loss of specimens was reduced with increasing Cr content in the cast ausferrite nodular iron. The wear loss of the sample cast ausferrite nodular iron with 0.4mass% Cr is the least. The wear loss began to increase while the Cr content is 0.6mass%. The wear loss of annealed ductile irons at different annealing temperatures was higher than that of as-cast samples. During the abrasive wear, the shear stress transformed austenite to martensite, and the hardness of specimens increased and the wear resistance of as-cast duc-tile cast iron was improved.

  3. Computed radiography (FCR) with a dual side reading system. Comparison with conventional radiography for visualization of nodular lung cancers

    Energy Technology Data Exchange (ETDEWEB)

    Ha-kawa, Shangkil; Yoshida, Tsunetaka; Sougawa, Mitsuharu; Harima, Yohko; Sawada, Satoshi [Kansai Medical Univ., Moriguchi, Osaka (Japan)

    2003-02-01

    To assess the diagnostic capability Fuji computed radiography (FCR) using a dual side reading system was compared to the conventional radiography using a film-screen system. Twenty-eight patients with lung cancer were examined with a new FCR system (FCR 5501D) and a conventional screen-film system concurrently. FCR utilizes a reading system that detects emissions from dual sides of imaging plate. Chest X-rays were obtained with same exposure factors in both systems. Image qualities of both systems were compared by two radiologists using a five-level score. There were no lesion that FCR images were inferior to film-screen images. The frequency of score +1 or +2 that FCR images were superior to film-screen images was 31% in large nodular shadows, 40% in accompanying shadows with a nodule, 67% of small nodular shadows, and 43% of the lymph node swelling in the hilum of the lung or mediastinum. In large nodular shadows which were the most frequent abnormality score +1 or +2 were observed in 43% of adenocarcinoma and 26% of squamous cell lung cancer. FCR with the dual side reading system is superior to the conventional screen-film system for visualization of nodular lung cancers. (author)

  4. CD57+ T-cells are a subpopulation of T-follicular helper cells in nodular lymphocyte predominant Hodgkin lymphoma

    NARCIS (Netherlands)

    Sattarzadeh, Ahmad; Diepstra, Arjan; Rutgers, Bea; van den Berg, Anke; Visser, Lydia

    2015-01-01

    BACKGROUND: Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is characterized by lymphocyte-predominant (LP) cells in a background of CD4+ CD57+ T-cells. These cells are normally present in the germinal center of lymphoid tissues. The cells rosetting LP cells are described to be PD-1 and

  5. CD57+ T-cells are a subpopulation of T-follicular helper cells in nodular lymphocyte predominant Hodgkin lymphoma

    NARCIS (Netherlands)

    Sattarzadeh, Ahmad; Diepstra, Arjan; Rutgers, Bea; van den Berg, Anke; Visser, Lydia

    2015-01-01

    BACKGROUND: Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is characterized by lymphocyte-predominant (LP) cells in a background of CD4+ CD57+ T-cells. These cells are normally present in the germinal center of lymphoid tissues. The cells rosetting LP cells are described to be PD-1 and BCL-

  6. Photodynamic therapy of nodular basal cell carcinoma with multifiber contact light delivery.

    Science.gov (United States)

    Thompson, Marcelo Soto; Andersson-Engels, Stefan; Svanberg, Sune; Johansson, T; Palsson, Sara; Bendsoe, Niels; Derjabo, A; Kapostins, J; Stenram, Unne; Spigulis, J; Svanberg, Katarina

    2006-01-01

    To overcome the limited treatment depth of superficial photodynamic therapy we investigate interstitial light delivery. In the present work the treatment light was delivered using a system in which three or six clear-cut fibers were placed in direct contact with the tumor area. This placement was thought to represent a step toward general purpose interstitial PDT. Twelve nodular basal cell carcinomas were treated employing delta-aminolevulinic acid and 635 nm laser irradiation. Fluorescence measurements were performed monitoring the buildup and subsequent bleaching of the produced sensitizer protoporphyrin IX. The treatment efficacy, judged at a 28-month follow-up, showed a 100% complete response. Two punch excisions at 7 months converted two partial responses to complete responses. One patient failed to appear at all follow-up sessions. The outcome of the treatments was comparable to superficial photodynamic therapy in terms of histological, clinical, and cosmetic results.

  7. Cracking behavior in a dissimilar weld between high silicon nodular cast iron and ferritic stainless steel

    Science.gov (United States)

    Kim, Sanghoon; Lee, Sangchul; Han, Kyutae; Hong, Seunggab; Lee, Changhee

    2010-06-01

    In this work, the microstructural evolution and cracking behavior of a dissimilar weld between high silicon nodular cast iron and ferritic stainless steel was investigated. An austenitic filler metal (Y309) was employed to produce the dissimilar weld. Microstructural analysis revealed that cracking formed at the unmixed zone (UMZ) and propagated into the partially melted zone (PMZ) in the bond line between the cast iron and the Y309, with hard layers formed around the bond line. The cracking behavior was strongly related to the difference in the melting points of cast iron and the Y309 filler metal, the local liquation of the laves phase, and the constitutional liquation between the graphite and austenite phases in the PMZ.

  8. 结节性筋膜炎的高频超声表现%High Frequency Ultrasound Features of Nodular Fasciitis

    Institute of Scientific and Technical Information of China (English)

    栾玉爽; 崔立刚; 贾建文; 陈文; 王金锐

    2012-01-01

    目的 探讨结节性筋膜炎的超声声像图特点及高频超声的诊断价值.资料与方法 回顾性分析14例经病理证实的结节性筋膜炎患者的临床及声像图资料,记录病变大小、位置、毗邻关系、灰阶超声表现及内部血流情况.结果 14例患者病灶最大径线0.4~4.4cm,平均(1.9±1.0) cm,发生于上肢者最常见(6例),均位于屈侧.根据病变深度不同,9例位于皮下深筋膜,2例位于皮下浅筋膜,位于肌间、肌内和皮肤真皮层内各1例.病变形态以梭形和椭圆形为主(10例).除1例表现为无回声外,其余均表现为低回声,所有病灶后方出现回声增强.11例病灶血流信号不丰富,3例血流信号丰富的病灶体积较大,平均直径为(2.8±1.1) cm,内部可探及高阻动脉血流频谱.结论 结节性筋膜炎的声像图表现具有特征性,超声检查结合病变发生部位及临床表现有助于明确诊断.%Purpose To explore the sonographic features of nodular fasciitis and the diagnostic value of high frequency ultrasound. Materials and Methods Fourteen confirmed nodular fasciitis cases were retrospectively studied. The size, distribution, location, gray scale sonographic appearance and internal color flow information of all lesions were analyzed. Results The maximum diameter ranged from 0.4 to 4.4 cm [average (1.9+1.0) cm]. Most lesions were located in upper extremities (6/14) and the volar aspect There were 9 (9/14) lesions located in the deep fascia, 2 in superficial fascia, 1 intramuscular, 1 intermuscular and 1 in the dermis. Most lesions were fusiform or oral shape (10/14). 13 lesions showed hypoechogenicity with posterior enhancement while 1 lesion was echo free. Most lesions (11/14) were hypovascular. 3 large lesions [average diameter (2.8± 1.1) cm] showed high RI arterial flow. Conclusion Nodular fasciitis has specific sonographic features. Sonographic findings combined with clinical features can help diagnose nodular fasciitis.

  9. An evaluation of the diagnostic efficacy of fine needle aspiration biopsy in patients operated for a thyroid nodular goiter

    Directory of Open Access Journals (Sweden)

    Janczak D

    2016-09-01

    Full Text Available Dariusz Janczak,1,2 Wiktor Pawlowski,1 Tadeusz Dorobisz,1,3 Dawid Janczak,4 Karolina Dorobisz,5 Michal Lesniak,1 Agnieszka Ziomek,1 Mariusz Chabowski1,2 1Department of Surgery, 4th Military Teaching Hospital, 2Department of Clinical Nursing, Division of Nursing in Surgical Procedures, 3Department of Clinical Basics of Physiotherapy, 4Department of Palliative Care Nursing, Faculty of Health Science, 5Department of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, Wroclaw, Poland Background: Thyroid cancer (TC comprises 1% of all carcinomas and is the most common malignancy of the endocrine system. The disease is more common in women, with its peak morbidity observed in 40–50-year-old patients. The main risk factors include radiation, iodine deficiency, hereditary background, and genetic mutations. Among all diagnosed thyroid nodules, 5%–30% will evolve into cancer. The gold-standard procedure in the preoperative evaluation of a nodular goiter, apart from ultrasonography, is fine needle aspiration (FNA biopsy. The FNA biopsy is favored for its simplicity, safety, and high specificity and sensitivity rates. Aim: The aim of our study was to evaluate the clinical efficacy of FNA based on the patients’ register. Materials and methods: In the Department of Surgery at the 4th Military Teaching Hospital in Wroclaw, 2,133 patients underwent thyroid surgery for thyroid goiter between 1996 and 2015. One hundred and eight cases of TC were diagnosed and of these, 66 patients had a preoperative FNA. Results: Fourteen FNA biopsies (21% revealed cancer, all of which were confirmed in the postoperative histopathology, although six cases of FNA-diagnosed cancer revealed a different histological type postoperatively. Eighteen FNA biopsies (27% were suspected of being malignant. A disturbingly high rate of “benign” FNA biopsies (32 cases; 48% revealed TC after surgery. Conclusion: It is of great importance that the quality and quantity of

  10. Syndrome of absent abdominal muscles: two cases with microcephaly, polymicrogyria, and cerebellar malformations

    Science.gov (United States)

    Heffner, Reid R.

    1970-01-01

    Two unique cases of the syndrome of absent abdominal muscles with central nervous system involvement are presented. Microcephaly, polymicrogyria, and cerebellar heterotopiae were present in both. In case 1 there was also absence of the corpus callosum and agenesis of the cerebellar vermis. In case 2 a count of anterior horn cells in the spinal cord showed a reduction of approximately 50% in the lower thoracic region. The pertinent literature is briefly discussed. The findings in the nervous system suggest that the syndrome is the result of defective embryogenesis during the first trimester. Images PMID:4250700

  11. 结节性甲状腺肿合并甲状腺癌的临床分析%Clinical analysis of patients with nodular goiter concomitant thyroid cancer

    Institute of Scientific and Technical Information of China (English)

    米泰宇; 刘开坤

    2011-01-01

    Objective To study the clinical features, diagnosis and treatment of patients with nodular goiter concomitant thyroid cancer. Methods The clinical data of 142 cases with concomitant thyroid cancer in 1 859 cases of nodular goiter admitted from January 2008 to January 2011 were retrospectively analyzed. Results All the 142 patients underwent surgical treatment, of which, there were 112 cases of primary surgery and 30 cases of secondary surgery. The ratio of men to women was 1 : 3. 1 , and the patients predominantly manifested as nodular goiter. Fifty-five cases (38. 7% ) were suspected of having concomitant thyroid cancer as suggested by preoperative ultrasound examination, of which 21 cases ( 18. 7 % ) had nodular psammomatous calcification. Twelve cases had cervical lymph node enlargement. Ninety patients underwent high-resolution color Doppler ultrasound examination, of which 68 cases (75. 6%) were suspected of having malignant lesion. Fine needle aspirations ( FNA ) were performed in 45 cases and the correct diagnostic rate was 48. 9%. The pathological examinations of intraoperative fast frozen section wereperformed in 138 patients , with accuracy rate of 96. 4% , 5 false negative cases and no false positive case. Of the patients with thyroid cancer, 83 cases were unifocal and 59 cases were multifocal, lesions less than 2. 0 cm accounted for 75. 3% , the main pathological type was papillary carcinoma (75. 4% ) , and 64 cases showed lymph node metastasis. The surgical procedures comprised ipsilateral total lobectomy combined with isthmusectomy, ipsilateral total lobectomy combined with isthmusectomy plus contralateral subtotal lobectomy or total thyroidectomy, and ipsilateral or bilateral central compartment ( level VI) lymph node dissection. The patients with enlarged cervical lymph nodes and suspected of having cervical lymph node metastasis before or during surgery underwent additional modified neck dissection. After surgery, all the 142 patients received

  12. Consideraciones sobre la rotura por fatiga de contacto en el hierro nodular austemplado. // Considerations on the contact fatigue failure in the austempered nodular iron.

    Directory of Open Access Journals (Sweden)

    D. Moreno Mur

    2004-09-01

    Full Text Available El presente trabajo considera como factor importante la variación de la geometría del nódulo de grafito en el cálculo delnúmero de ciclos necesarios durante la formación de un pitting en una fundición nodular austemplada. En este caso se tomóen cuenta la aparición de una energía de deformación alrededor de este y se consideró el material con propiedadeshomogéneas. Es analizada la influencia de la variación de la carga, los valores de los diámetros de contacto, el tamaño delnódulo de grafito, de la profundidad donde aparece el nódulo en la geometría del nódulo, por ser estos factores importantesen la iniciación y propagación de grietas por fatiga de contacto. Se trabajó con las profundidades donde aparecen lasmáximas tensiones tangenciales, las cuales se obtuvieron de las expresiones de Hertz, con valores de carga dentro del límiteelástico. Luego se modela por elementos finitos el mecanismo de fractura, en el sistema ALGOR 12.06, y se realiza unaregresión múltiple en el sistema STATGRAPHICS, obteniendo modelos con buenos coeficientes de regresión y niveles deconfianza.Palabras claves: Fatiga de contacto, factura, grietas, nódulo grafito, FEM._________________________________________________________________________Abstract.The present paper deal with the failure of contact fatigue in the autempered ductil iron considering the graphite nodulesvariation as an important factor in th calculation of the number of cycles nedded for pitting, starting from theoreticalconsiderations, developing a methodology for the calculation. The influence of load variation is analyzed, the values of thecontact diameters, the size of graphite nodules, the depth where the nodule appears in the geometry of the nodule, areimportant factors in the initiation and propagation of contact fatigue cracks. It is considered the depths in wich the maximstangential tensions appear, which were obtained by Hertz expressions. An analysis by the method of

  13. Phosphorus and Nitrogen Interactions in Field-Grown Soybean as Related to Genetic Attributes of Root Morphological and Nodular Traits

    Institute of Scientific and Technical Information of China (English)

    Rui-Bin KUANG; Hong LIAO; Xiao-Long YAN; Ying-Shan DONG

    2005-01-01

    Two field experiments with different soybean (Glycine max L.) materials were conducted to investigate the interactions between phosphorus (P) and nitrogen (N) as related to the genetic attributes of root morphological and nodular traits. In experiment one, 13 cultivated soybean varieties were grown in a field with relatively low soil P and N availability. P application with 160 kg P/hm2 as triple superphosphate produced a significant simultaneous increase in the content of both P and N in shoot, demonstrating positive P and N interactions. The addition of P also increased root dry weight, root nodule number, nodule mass, nodule size, and nodulation index, but decreased root length and root surface area, indicating that P may affect N nutrition in soybean through a number of root morphological and nodular traits. Interestingly,like P content, N content appeared to be more correlated with root morphological traits (root weight, root length, and root surface area) than with root nodular traits (nodule number, nodule size, nodule mass, and nodulation index) at both P levels, implying that N taken up by the roots may contribute more to the plant N status than biological N2 fixation under the present experimental conditions. In experiment two, 57 soybean lines of a recombinant inbred line (RIL) population derived from a cross between a cultivated variety and a wild genotype were grown on another field site with moderately sufficient P and N levels to further characterize the genetic attributes of root morphological and nodular traits and their relationships with P and N interactions. The results indicated that all morphological and nodular traits measured continually segregated in the RIL population with a normal distribution of the phenotypic values, indicating that these traits are possibly controlled by quantitative trait loci (QTLs). Genetic analysis revealed that all these root traits had relatively low heritabilities (h2b=74.12, 70.65, 73.76, 56.34, 52.59, and 52

  14. Nodular lesions seen on CTAP not on conventional CT in known hepatocellular carcinoma (HCC) patients: positive predictive value for HCC or precusor of HCC

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Jae Chun; Lee, Yong Woo; Hwang, Mi Soo [College of Medicine, Yeungnam University, Daegu (Korea, Republic of)

    1995-01-15

    To evaluate intrahepatic nodular lesions detected on CTAP but not on conventional contrast CT in regard to its relationship with satellite nodules or borderline malignancies. From June 1991 to March 1994, CTAP was undertaken in 132 cases with confirmed hepatocellular carcinoma (HCC), or which 35 cases having 82 lesions were suitable for analysis (excluding the cases which had no follow-up studies, showed segmental abnormal portal perfusion, no additional lesions and, or inumerable lesions). The CTAP findings were compared with those on artery dominant imaging studies (angiography, DSA, bolus dynamic CT, arterial CT, Lipiodol CT) taken during the same period (to confirm the presence of lesions) and the findings on follow-up imaging studies (to assess the development of malignancy). Arterial vascularity was identified in 35 of 82 lesions (42.7%) on arterial dominant imaging studies. Development into malignancy was identified on follow-up imaging studies in 25 of remained 47 lesions (53.2%). The total positive predictive value of nodules on CTAP was 73.2% (35 + 25/82), but the predictive value for HCC by follow-up only was 53.2%. Given the difficulties in detecting intranodular arterial flow and the short follow-up duration in many patients, the actual positive value might be higher.

  15. B-cell transcription factors Pax-5, Oct-2, BOB.1, Bcl-6, and MUM1 are useful markers for the diagnosis of nodular lymphocyte predominant Hodgkin lymphoma.

    Science.gov (United States)

    Herbeck, Rosemarie; Teodorescu Brînzeu, D; Giubelan, Marioara; Lazăr, Elena; Dema, Alis; Ioniţă, Hortensia

    2011-01-01

    In some instances, the overlap in morphologic features and antigen expression between nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) and classical Hodgkin lymphoma (cHL) can cause confusion in the diagnosis. In these cases, the transcription factors (TFs) B-cell specific activator protein (BSAP)/Pax-5, octamer binding protein-2 (Oct-2), B-lymphocyte-specific co-activator BOB.1/OBF.1, Bcl-6 protein and multiple myeloma-1/interferon regulatory factor-4 (MUM1/IRF-4) may aid in clarifying the diagnosis. Twenty-two cases of NLPHL were studied for the immunohistochemical expression of Pax-5, Oct-2, BOB.1, Bcl-6 protein and MUM1/IRF-4. Our results sustain the usefulness of the selected set of TFs to diagnose and distinguish NLPHL from cHL since Pax-5, Oct-2, BOB.1 and Bcl-6 are consistently expressed by lymphocyte predominant (LP) cells and reported by others to be often unexpressed in Hodgkin and Reed-Sternberg cells. By contrast, MUM1/IRF-4 protein scored negative in the majority of LP cells, but is reported to be expressed in almost all cases of cHL. Thus, although the expression of transcription factors is very heterogeneous, their simultaneous implementation for positive and differential diagnosis may be useful.

  16. Vitamin K deficiency bleeding presenting as nodular purpura in infancy: A rare and life-threatening entity

    Directory of Open Access Journals (Sweden)

    Pratik Gahalaut

    2013-01-01

    Full Text Available Vitamin K deficiency bleeding (VKDB disorder is an uncommon entity, which occurs due to inadequate activity of vitamin K-dependant coagulation factors. An 8-months-old exclusively breast-fed male infant presented with multiple, purpuric and nodular non-collapsible swellings on trunk of 4 days duration. Investigations revealed raised activated partial thromboplastin time and prothrombintime. Fibrinogen level and platelet counts were normal. Late VKDB usually presents as intra-cranial or mucosal hemorrhages. [1] Though skin and mucosal bleeding may occur in 1/3 rd of infants with VKDB, ′nodular purpura′ is not the common presenting feature. Earlier recognition of VKDB and immediate investigation/treatment helps prevent the potentially fatal outcome of the disease. Very little is mentioned about this entity in dermatology literature.

  17. Progression from an Immature Teratoma with Miliary Gliomatosis Peritonei to Growing Teratoma Syndrome with Nodular Gliomatosis Peritonei

    Directory of Open Access Journals (Sweden)

    Yuh-Lin Hsieh

    2009-04-01

    Full Text Available A 4½-year-old girl presented with an incompletely resected, huge, immature abdominal teratoma, elevated serum alpha-fetoprotein (AFP, and numerous miliary gliomatosis peritonei (GP. Two courses of chemotherapy resulted in normalization of her AFP level and marked tumor shrinkage. Further chemotherapy was interrupted by complications. During treatment for these complications, ascites increased and the tumor enlarged, but serum AFP remained within the normal range. Second-look surgery revealed that the tumor had changed histologically to a mature teratoma, and GP had enlarged to nodular size, causing massive ascites. The still incompletely resected, growing mature teratoma was reduced with inter-feron. Nodular GP and ascites slowly regressed with interferon use, and finally disappeared after several months. One residual mass thought to be GP was reduced by gamma-knife surgery 3 years later.

  18. A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German Shepherd dog

    NARCIS (Netherlands)

    Lingaas, F; Comstock, KE; Kirkness, EF; Sorensen, A; Aarskaug, T; Hitte, C; Nickerson, ML; Moe, L; Schmidt, LS; Thomas, R; Breen, M; Galibert, F; Zbar, B; Ostrander, EA

    2003-01-01

    Hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis (RCND) is a naturally occurring canine kidney cancer syndrome that was originally described in German Shepherd dogs. The disease is characterized by bilateral, multifocal tumors in the kidneys, uterine leiomyomas and nodules

  19. Nodular goiter with amyloid deposition in an elderly patient: fine-needle cytology diagnosis and review of the literature

    OpenAIRE

    Di Crescenzo, Vincenzo; Garzi, Alfredo; Petruzziello, Fara; Cinelli, Mariapia; Catalano, Lucio; Zeppa, Pio; Vitale, Mario

    2013-01-01

    Background Amyloidosis is a systemic disease characterized by the extracellular deposition of amyloid fibrils in different organs and tissues. The thyroid gland may be affected by diffuse or nodular amyloid deposits, along with multiple myeloma (MM) (Amyloid Light-Chain Amyloidosis, AL amyloidosis) or chronic inflammatory diseases (Amyloid A Amyloidosis, AA amyloidosis), but thyroid gland involvement rarely appears as the first clinical manifestation in both conditions. The present study repo...

  20. Risk of Thyroid Nodular Disease and Thyroid Cancer in Patients with Acromegaly – Meta-Analysis and Systematic Review

    OpenAIRE

    Kosma Wolinski; Agata Czarnywojtek; Marek Ruchala

    2014-01-01

    INTRODUCTION: Acromegaly is a quite rare chronic disease caused by the increased secretion of growth hormone (GH) and subsequently insulin - like growth factor 1. Although cardiovascular diseases remains the most common cause of mortality among acromegalic patients, increased prevalence of malignant and benign neoplasms remains a matter of debate. The aim of this study is to evaluate the risk of thyroid nodular disease (TND) and thyroid cancer in patients with acromegaly. MATERIALS AND METHOD...

  1. Formation of Nodular Structures and Nitrogen Fixation by Rhizobia on Oilseed Rape Roots Following Treatment with Pectionolytic Bacteria

    Institute of Scientific and Technical Information of China (English)

    HUXIAOJIA; ZHANGXUEJIANG

    1996-01-01

    Nodular structures were formed by rhizobia on oilseed rape oilseed rape roots following treatment with pectinolytic bacteria.Nodules developed within 50 days.Photomicrograph of nodule cells showed that the capsulated bacteria were intracellular.Rhizobia resolated from the root nodules retained not only the ability of nodulation but also the characteristic of resistance to 100μg neomycin mL-1,A low nitrogenase activity of the nodules was determined by the method of acetylene reduction.

  2. Neurofibromatosis type 1 and pregnancy: The transformation of a nodular to cystic neurofibroma in the cervical region

    Directory of Open Access Journals (Sweden)

    Rodrigo Ramos-Zúñiga

    2015-01-01

    Conclusion: The transformation of a nodular to cystic neurofibroma during pregnancy is a very rare presentation, which may exacerbate the clinical symptomatology depending on the topography of the lesion due to the mass effect it may create. This condition may alert to the recommendations and vigilance in patients with NF1, who are pregnant or are planning on a future pregnancy. The neurosurgical resolution in this region is safe and beneficial.

  3. Response to Switch from Intermittent Therapy to Daily Therapy for Refractory Nodular Bronchiectatic Mycobacterium avium Complex Lung Disease

    OpenAIRE

    Koh, Won-Jung; Jeong, Byeong-Ho; Jeon, Kyeongman; Park, Hye Yun; Kim, Su-Young; Huh, Hee Jae; Ki, Chang-Seok; Lee, Nam Yong; Shin, Sung Jae; Daley, Charles L.

    2015-01-01

    Intermittent three-times-weekly antibiotic therapy is recommended for the initial treatment of patients with noncavitary nodular bronchiectatic Mycobacterium avium complex lung disease. Although some experts recommend switching from intermittent to daily therapy for patients whose sputum has persistent positive cultures after intermittent therapy, the clinical efficacy of these modifications is unknown. Of 20 patients whose sputum had persistent positive cultures after 12 months of intermitte...

  4. An Interpretation of The Hairy Ape from Foucault' s Concept of Heterotopia%空间理论视域下的《毛猿》解读

    Institute of Scientific and Technical Information of China (English)

    周和军

    2012-01-01

    主要采用福柯的空间理论来观照奥尔尼的经典剧作《毛猿》,通过对剧中的五个主要空间:船舱、五马路、监狱、世界产联和动物园的分析,揭示了其隐喻的空间与权力的关系以及如何利用空间使权力的实施达到最优化状态。%This paper attempts to interpret Eugene 0' Neill' s The Hairy Ape, a classic play that is basically a rant against the ruling classes, from Michel Foucault' s concept of heterotopia. An analysis of five major spaces existent in the play, namely, the cabin, the streets, the prison, and the Industrial Workers of the World, unveils the relationship between spaces and power and reveals how to manipulate spaces to optimize the actualization of power.

  5. Micropolíticas, cartografias e heterotopias urbanas: Derivas teórico-metodológicas sobre a aventura das (nas cidades contemporâneas

    Directory of Open Access Journals (Sweden)

    Rafael Estrada Mejía

    2012-04-01

    Full Text Available A que nos referimos quando falamos de micropolíticas, cartografias e heterotopias urbanas? Quais são suas contribuições e implicações em relação à antropologia das (nas cidades contemporâneas? Neste trabalho evidencio que a prolífica distorção destes conceitos teria potencializado a sustentação de um regime identitário nos processos de subjetivação. Rastreio seu uso e enfatizo sua relação com a alteridade, entendida como o campo de forças vivas que nos atingem e se apresentam em nossos corpos por meio de sensações, isto é, a “presença viva” com a qual é possível criar nossos “territórios existenciais”, requisito para que deixe por fim de constituir um mero objeto de “projeção de imagens preestabelecidas”. Procuro em seguida indicar a relevância tanto teórica quanto pragmática dos mesmos a partir de uma revisão bibliográfica que privilegia uma linha de pensamento, suspeitamente esquecida, que navega na contramão do mainstream da antropologia, apesar de suas profusas expressões no Brasil desde pelo menos a década de 1980.

  6. Nodular features from Proterozoic Sonia Sandstone, Jodhpur Group, Rajasthan: A litho-biotectonic perspective

    Indian Academy of Sciences (India)

    Arvind Singh; Vikash Anand; Prabhas Pandey; Partha Pratim Chakraborty

    2013-04-01

    The Sonia Sandstone of Proterozoic Jodhpur Group, Marwar Supergroup, exposed around the Sursagar dam area of Jodhpur town, Rajasthan exposes two varieties of nodular features, often spectacular in shape and size. On the basis of mode of occurrence (intra- or interbed) and stratal involvement (single or multiple) the features are classified as Type I and II. From granulometric and microscopic (optical and scanning electron) studies carried out on sandstones from the nodules and their host sandstones, geochemical analysis (SEM-EDAX) of intragranular cement present within Type I nodules, and appreciation of control of associated fracture system within Type II nodules, it is proposed that the two types of nodules vary in their formative mechanism and stage of formation. While Type I nodules are identified as product of processes operative at the early diagenetic, pre-lithification stage, the Type II nodules are undoubtedly the result of post-lithification origin triggered by formation of fracture system. Here we propose generation of vapour pressure (not exceeding the overlying hydrostatic pressure) by decay of thin, laterally impersistent organic mat as the causal factor for intrabed nodule (Type I) formation, which forced rarefication of local grain packing \\tetit {vis-a-vis} early diagenetic silica cementation. The study warrants necessity of more studies on nodules to understand possible roles of organic matter and bedtransgressive fracture systems in their formation, going beyond the generalised secondary mineralization hypothesis.

  7. A Rare Coexistence of Retroperitoneal Pararenal Castleman's Disease with Focal Nodular Hyperplasia

    Directory of Open Access Journals (Sweden)

    Theodosios Theodosopoulos

    2013-01-01

    Full Text Available Castleman's disease is a distinct form of lymph node hyperplasia divided into a solitary and a multicentric type. The solitary type occurs most commonly in the mediastinum and is usually asymptomatic. We present a patient with Castleman's disease of the hyaline-vascular solitary type located in the retroperitoneum. The patient was a 38-year-old male, who presented to our hospital with fever. The imaging workup revealed a retroperitoneal mass, measuring 4 × 6 cm, located lateral to the aorta, inferior to the left renal artery and vein, and posterior to the left testicular vein. At workup, a solid hepatic lesion, 3 cm in diameter, located in the left lobe of the liver, segment IV, was also identified. Both lesions were surgically excised. The retroperitoneal tumor had the features of angiofollicular hyperplasia (Castleman's disease, hyaline-vascular type, whereas a diagnosis of focal nodular hyperplasia was made for the hepatic lesion. The patient is well at fourty months followup postoperatively. Surgical excision is the treatment of choice for unifocal Castleman's disease.

  8. PKA regulatory subunit 1A inactivating mutation induces serotonin signaling in primary pigmented nodular adrenal disease.

    Science.gov (United States)

    Bram, Zakariae; Louiset, Estelle; Ragazzon, Bruno; Renouf, Sylvie; Wils, Julien; Duparc, Céline; Boutelet, Isabelle; Rizk-Rabin, Marthe; Libé, Rossella; Young, Jacques; Carson, Dennis; Vantyghem, Marie-Christine; Szarek, Eva; Martinez, Antoine; Stratakis, Constantine A; Bertherat, Jérôme; Lefebvre, Hervé

    2016-09-22

    Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of ACTH-independent hypercortisolism. The disease is primarily caused by germline mutations of the protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene, which induces constitutive activation of PKA in adrenocortical cells. Hypercortisolism is thought to result from PKA hyperactivity, but PPNAD tissues exhibit features of neuroendocrine differentiation, which may lead to stimulation of steroidogenesis by abnormally expressed neurotransmitters. We hypothesized that serotonin (5-HT) may participate in the pathophysiology of PPNAD-associated hypercortisolism. We show that PPNAD tissues overexpress the 5-HT synthesizing enzyme tryptophan hydroxylase type 2 (Tph2) and the serotonin receptors types 4, 6, and 7, leading to formation of an illicit stimulatory serotonergic loop whose pharmacological inhibition in vitro decreases cortisol production. In the human PPNAD cell line CAR47, the PKA inhibitor H-89 decreases 5-HT4 and 5-HT7 receptor expression. Moreover, in the human adrenocortical cell line H295R, inhibition of PRKAR1A expression increases the expression of Tph2 and 5-HT4/6/7 receptors, an effect that is blocked by H-89. These findings show that the serotonergic process observed in PPNAD tissues results from PKA activation by PRKAR1A mutations. They also suggest that Tph inhibitors may represent efficient treatments of hypercortisolism in patients with PPNAD.

  9. PKA regulatory subunit 1A inactivating mutation induces serotonin signaling in primary pigmented nodular adrenal disease

    Science.gov (United States)

    Bram, Zakariae; Louiset, Estelle; Renouf, Sylvie; Duparc, Céline; Boutelet, Isabelle; Rizk-Rabin, Marthe; Libé, Rossella; Young, Jacques; Carson, Dennis; Vantyghem, Marie-Christine; Szarek, Eva; Martinez, Antoine; Stratakis, Constantine A.; Bertherat, Jérôme

    2016-01-01

    Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of ACTH-independent hypercortisolism. The disease is primarily caused by germline mutations of the protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene, which induces constitutive activation of PKA in adrenocortical cells. Hypercortisolism is thought to result from PKA hyperactivity, but PPNAD tissues exhibit features of neuroendocrine differentiation, which may lead to stimulation of steroidogenesis by abnormally expressed neurotransmitters. We hypothesized that serotonin (5-HT) may participate in the pathophysiology of PPNAD-associated hypercortisolism. We show that PPNAD tissues overexpress the 5-HT synthesizing enzyme tryptophan hydroxylase type 2 (Tph2) and the serotonin receptors types 4, 6, and 7, leading to formation of an illicit stimulatory serotonergic loop whose pharmacological inhibition in vitro decreases cortisol production. In the human PPNAD cell line CAR47, the PKA inhibitor H-89 decreases 5-HT4 and 5-HT7 receptor expression. Moreover, in the human adrenocortical cell line H295R, inhibition of PRKAR1A expression increases the expression of Tph2 and 5-HT4/6/7 receptors, an effect that is blocked by H-89. These findings show that the serotonergic process observed in PPNAD tissues results from PKA activation by PRKAR1A mutations. They also suggest that Tph inhibitors may represent efficient treatments of hypercortisolism in patients with PPNAD. PMID:27699247

  10. OBSERVATION OF FATIGUE CRACK PATHS IN NODULAR CAST IRON AND ADI MICROSTRUCTURES

    Directory of Open Access Journals (Sweden)

    Lukáš Bubenko

    2009-07-01

    Full Text Available When speaking about quality of construction materials, fatigue crack propagation resistance is one of the most important considered properties. That is essentially influenced by character of matrix. Here presented contribution deals with the fatigue crack propagation mode through the matrix of as-cast nodular cast iron (NCI and austempered ductile iron (ADI, whereas influence of microstructure has been considered and discussed. Experimental materials used in presented contribution were pearlitc-ferritic NCI and heat treated ADI 800. Pearlitic-ferritic NCI was used as the base for ADI production. Experiments were performed on mini round compact tension (RCT specimens using an Amsler vibrophore. Fatigue crack paths in both materials were investigated and compared. Light microscopy was used to analyze the microstructure, crack initiation and propagation within broken specimens. In both tested materials fatigue cracks always initiated at graphite-matrix interface, while graphite nodules remained generally unbroken, eventually only surface of nodules was damaged. Though, comparing two materials with different microstructures, the diversity of fatigue crack propagation modes at high deltaK and low deltaK was observed.

  11. Application of Averaged Voronoi Polyhedron in the Modelling of Crystallisation of Eutectic Nodular Graphite Cast Iron

    Directory of Open Access Journals (Sweden)

    A.A. Burbelko

    2013-01-01

    Full Text Available The study presents a mathematical model of the crystallisation of nodular graphite cast iron. The proposed model is based on micro- andmacromodels, in which heat flow is analysed at the macro level, while micro level is used for modelling of the diffusion of elements. The use of elementary diffusion field in the shape of an averaged Voronoi polyhedron [AVP] was proposed. To determine the geometry of the averaged Voronoi polyhedron, Kolmogorov statistical theory of crystallisation was applied. The principles of a differential mathematical formulation of this problem were discussed. Application of AVP geometry allows taking into account the reduced volume fraction of the peripheral areas of equiaxial grains by random contacts between adjacent grains.As a result of the simulation, the cooling curves were plotted, and the movement of "graphite-austenite" and "austenite-liquid” phaseboundaries was examined. Data on the microsegregation of carbon in the cross-section of an austenite layer in eutectic grains wereobtained. Calculations were performed for different particle densities and different wall thicknesses. The calculation results were compared with experimental data.

  12. EFFECTS OF FRICTION STIR PROCESSING ON MICROSTRUCTURAL, HARDNESS AND DAMPING CHARACTERISTICS OF FERRITIC NODULAR CAST IRON

    Directory of Open Access Journals (Sweden)

    ABDULSALAM Y.OBAID

    2017-01-01

    Full Text Available Experimental investigations had been done in this study to explore the effects of friction stir processing (FSP on the microstructure, hardness and damping capacity of fully ferrite nodular cast iron ASTM A536, grade 65-45-12. The main process parameters employed in this study were the rotational speed, translational speed and axial applied load which were varied within selected ranges. Their influence to be analysed and optimized for best process conditions compared with as cast material. Detailed investigations were carried out using optical microscopy, hardness test and impact test. Results showed that graphite grain refinements of 2-3 times the original size and phase transformations of a fully ferritic to bainite/martensite were achieved within the processed zone and across thickness. Matrix modifications caused improvement in hardness of 3.5 times compared to hardness of original cast iron. Increment in the damping capacity up to 14% was achieved. The stated improvements were related to the process parameters employed in the test.

  13. [Primary pigmented nodular adrenocortical disease as cause of Cushing's syndrome associated with Carney complex].

    Science.gov (United States)

    Dumić, Miroslav; Janjanin, Nevena; Uroić, Anita Spehar; Ille, Jasenka; Skegro, Mate; Kusec, Vesna; Marjanac, Igor; Matić, Toni; Jelasić, Drazen

    2006-01-01

    We report a 11-year-old girl and two 14-year-old boys with Cushing's syndrome due to primary pigmented nodular adrenocortical disease (PPNAD). In these patients, hypercortisolism is a consequence of autonomous cortisol secretion from adrenal glands and is ACTH-independent. Besides PPNAD, the girl had lentigines, spotty pigmentation on her bucal mucosa and lips and she also had schwannoma. One of the reported boys had prolactinoma. Considering this, those two patients fulfill the criteria for Carney complex which is a type of multiple endocrine neoplasia syndromes inherited in an autosomal dominant trait. The other boy had PPNAD but no other obvious signs of Carney complex were noticed. Family study didn't reveal any clinical or laboratory signs of Carney complex in our patients' first relatives. All of our patients underwent bilateral adrenalectomy (in one of the boys laparoscopic surgery was performed). Glucocorticoid and mineralocorticoid substitution has been started. Adrenal glands were macroscopically normal but pathohistological analysis confirmed the diagnosis of PPNAD.

  14. Contrast-enhanced ultrasound of focal nodular hyperplasia: a matter of size

    Energy Technology Data Exchange (ETDEWEB)

    Bertin, Caroline [Hopital Beaujon APHP, Radiology Department, Clichy (France); Egels, Sophie; Huynh-Charlier, Isabelle [Hopital Pitie-Salpetriere APHP, Radiology Department, Paris (France); Wagner, Mathilde [Hopital Pitie-Salpetriere APHP, Radiology Department, Paris (France); Universite Paris Diderot, INSERM, UMR 1149, Laboratoire IPMA, Centre de Recherche sur l' Inflammation, Faculte de Medecine X Bichat, Paris (France); Vilgrain, Valerie [Hopital Beaujon APHP, Radiology Department, Clichy (France); Universite Paris Diderot, INSERM, UMR 1149, Laboratoire IPMA, Centre de Recherche sur l' Inflammation, Faculte de Medecine X Bichat, Paris (France); Lucidarme, Olivier [Hopital Pitie-Salpetriere APHP, Radiology Department, Paris (France); Sorbonne Universites, UPMC Univ Paris 06, CNRS UMR 7371, INSERM UMRS 1146, Laboratoire d' Imagerie Biomedicale, Paris (France); Groupe Hospitalier Pitie-Salpetriere - Charles Foix, Service de Radiologie Polyvalente et Oncologique, Paris (France)

    2014-10-15

    To assess the contrast-enhanced ultrasound (CEUS) frequencies of centrifugal enhancement, spoke-wheel sign and central scar in focal nodular hyperplasia (FNH) as a function of lesion size. Ninety-four FNHs were retrospectively reviewed to assess their largest diameter and enhancement pattern, including centrifugal enhancement from one central artery, spoke-wheel sign, diffuse or centripetal enhancement, central scar and late-phase washout. Mean FNH-lesion size was 3.7 ± 2.1 cm. Only 43.6 % of FNHs had centrifugal enhancement, with a spoke-wheel pattern (23.4 %) or without (20.2 %), while 56.4 % showed diffuse or centripetal enhancement. Centrifugal enhancement was observed in 73.9 % of FNHs ≤3.1 cm and 14.6 % of FNHs >3.1 cm (P < 10{sup -4}). Size and frequency of centrifugal enhancement were negatively correlated (r = -0.57, P < 10{sup -4}). The spoke-wheel pattern was also seen more frequently in smaller (37 %) than in larger FNHs (10.4 %) (P < 10{sup -3}). Late-phase washout was described in 5.3 % of FNHs and was not size-dependent. Lesions with a central scar were larger than those without, respectively, 5.7 ± 1.7 and 3.6 ± 2.0 cm (P = 0.012). Typical centrifugal enhancement yielding a confident FNH diagnosis is seen significantly more frequently when the lesion is ≤3.1 cm. (orig.)

  15. Variations in the size of focal nodular hyperplasia on magnetic resonance imaging.

    Science.gov (United States)

    Ramírez-Fuentes, C; Martí-Bonmatí, L; Torregrosa, A; Del Val, A; Martínez, C

    2013-01-01

    To evaluate the changes in the size of focal nodular hyperplasia (FNH) during long-term magnetic resonance imaging (MRI) follow-up. We reviewed 44 FNHs in 30 patients studied with MRI with at least two MRI studies at least 12 months apart. We measured the largest diameter of the lesion (inmm) in contrast-enhanced axial images and calculated the percentage of variation as the difference between the maximum diameter in the follow-up and the maximum diameter in the initial study. We defined significant variation in size as variation greater than 20%. We also analyzed predisposing hormonal factors. The mean interval between the two imaging studies was 35±2 months (range: 12-94). Most lesions (80%) remained stable during follow-up. Only 9 of the 44 lesions (20%) showed a significant variation in diameter: 7 (16%) decreased in size and 2 (4%) increased, with variations that reached the double of the initial size. The change in size was not related to pregnancy, menopause, or the use of birth control pills or corticoids. Changes in the size of FNHs during follow-up are relatively common and should not lead to a change in the diagnosis. These variations in size seem to be independent of hormonal factors that are considered to predispose. Copyright © 2011 SERAM. Published by Elsevier Espana. All rights reserved.

  16. Calorimetric analysis of heating and cooling process of nodular cast iron

    Directory of Open Access Journals (Sweden)

    Bińczyk F.

    2007-01-01

    Full Text Available The study presents the results of investigations of the thermal effects which take place during heating and cooling of samples of the nodular graphite cast iron taken from the stepped test casting of the wall thicknesses amounting to 5, 10, 15 and 20 mm. For investigations, a differential scanning calorimeter, type Multi HTC S60, was used. During heating, three endothermic effects related with pearlite decomposition, phase transformation α → γ, and carbon dissolution in austenite were observed on a DSC diagram. During cooling, two exothermic effects related with phase transformation γ→ α and pearlite formation were observed to consecutively take place on a DSC diagram. The values of the enthalpy of these processes differ and depend on the initial microstructure of the examined samples. The metallic matrix in 5 mm sample after the process of heating and cooling changes totally in favour of ferrite. The same effect, though less advanced in intensity, takes place in 10 mm sample, while in 15 and 20 mm samples the matrix constitution remains unchanged. The higher is the content of ferrite in samples, the stronger is the endothermic effect of the α → γ transformation and the weaker is the endothermic effect related with carbon dissolution in austenite. The total of the endothermic effects (heating is reduced, while that of the exothermic effects (cooling increases along with the increasing thickness of walls in a stepped test casting, from which samples for the investigations were taken.

  17. Characterization of nodular and thermal defects in hafnia/silica multilayer coatings using optical, photothermal, and atomic force microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Stolz, C.J.; Yoshiyama, J.M.; Salleo, A.; Wu, Z.L.; Green, J.; Krupka, R.

    1997-12-24

    Multilayer coatings manufactured from metallic hafnium and silica sources by reactive electron beam deposition, are being developed for high fluence optics in a fusion laser with a wavelength of 1053 nm and a 3 ns pulse length. Damage threshold studies have revealed a correlation between laser damage and nodular defects, but interestingly laser damage is also present in nodule-free regions. Photothermal studies of optical coatings reveal the existence of defects with strong optical absorption in nodule-free regions of the coating. A variety of microscopic techniques were employed to characterize the effects for a better understanding of the thermal properties of nodular defects and role of thermal defects in laser damage. Photothermal microscopy, utilizing the surface thermal lensing technique, was used to map the thermal characteristics of 3 mm x 3 mm areas of the coatings. High resolution subaperture scans, with a 1 pm step size and a 3 um pump beam diameter, W= conducted on the defects to characterize their photothermal properties. Optical and atomic force microscopy was used to visually identify defects and characterize their topography. The defects were then irradiated to determine the role of nodular and thermal defects in limiting the damage threshold of the multilayer.

  18. Systemic oxidative stress to nucleic acids is unaltered following radioiodine therapy of patients with benign nodular goiter

    DEFF Research Database (Denmark)

    Bonnema, Steen J; Stovgaard, Elisabeth S; Fast, Søren;

    2015-01-01

    BACKGROUND: Little is known about the whole body oxidative stress burden following radioactive iodine ((131)I) therapy of thyroid diseases. METHODS: We studied 17 patients with benign nodular goiter treated with (131)I therapy. The targeted thyroid dose was 50 Gy in 11 patients pretreated with 0....... in the thyroid gland, but the study supports that (131)I therapy of benign nodular goiter carries no or only a minute risk of developing subsequent malignancies. It remains to be explored whether our findings also apply to hyperthyroid disorders.......BACKGROUND: Little is known about the whole body oxidative stress burden following radioactive iodine ((131)I) therapy of thyroid diseases. METHODS: We studied 17 patients with benign nodular goiter treated with (131)I therapy. The targeted thyroid dose was 50 Gy in 11 patients pretreated with 0.......1 mg of recombinant human TSH (rhTSH). In 6 patients, the applied thyroid dose was 100 Gy without rhTSH prestimulation. Well-established biomarkers of oxidative stress to RNA (8-oxo-7,8-dihydroguanosine; 8-oxoGuo) and DNA (8-oxo-7,8-dihydro-2'-deoxyguanosine; 8-oxodG) were measured in freshly voided...

  19. Application of magnetic source imaging in localizing the epileptic foci in patients with grey matter heterotopia%磁源性影像在灰质异位症伴癫痫患者癫痫灶定位中的应用

    Institute of Scientific and Technical Information of China (English)

    孙吉林; 吴杰; 贾秀川; 李素敏

    2011-01-01

    normal findings in 2 cases, subcortical heterotopia in 4 cases, and nodulor heterotopia in 2 cases with one having schizencephaly. The epileptic foci defined by MSI were at right temporal lobe in 2 cases, left frontal lobe in 2 cases, biparietal lobe in1 case, left parietal lobe in 1 case, left temporal lobe in 1 case, and left frontal-parietal lobe in 1 case. The epileptic foci defined by MSI were completely overlaid with area of GMH in 4 cases, closely behind the area of GMH in case, and partly overlaid with area of GMH in 1 cases with size larger than that of the latter. One patient showed two epileptic foci with one located within the area of GMH and the other one 2 centimeters anterior to the area of GMH.One case's epileptic focus located 2 centimeters posteolateral to the area of GMH . The locations of the epileptic foci defined by MSI showed no difference with those defined by ECoG in all patients. According to Engel classification of treatment effect of epilepsy, 6 patients achieved Engle class Ⅰ ( seizure free after operation ), and 2 patients Engel class Ⅳ ( no changes in the frequcenty of occurrence of seizures before and after operation ). Conclusion MSI can noninvasively and precisely localize the epileptic foci before operation in patients with GMH and seizure.

  20. The Classification and the Causes of Nodular Limestone%瘤状灰岩的分类及成因研究

    Institute of Scientific and Technical Information of China (English)

    刘荞菲

    2015-01-01

    Nodular limestone is one of the more common with nodular form and similar to the output characteristics of carbonate rocks, consists of two parts, tumors and the substrate. Nodular limestone has variety of colors and forms, contains a lot of bioclastic, the rocks development suture line structure and some tensile cracks, these not only can be channels of hydrocarbon migration, also can become the oil and gas reservoir space. This article through to consult the relevant literature of nodular limestone, summarized the distribution of nodular limestone in our country, the classification, the classification and the causes, the significance of nodular limestone.%瘤状灰岩是一种较常见的具有瘤状形态及相似产出特征的碳酸盐岩,由瘤体和基质两部分组成。瘤状灰岩的颜色多样,形态各异,含有多种生物碎屑,岩层中发育缝合线构造和一些张性裂缝,不仅可成为油气运移的通道,也可成为油气的储集空间。通过对瘤状灰岩相关文献的查阅,总结了瘤状灰岩在我国的分布、分类、特征及成因、意义。

  1. Prevalence of simple nodular goiter and Hashimoto's thyroiditis in current, previous, and never smokers in a geographical area with mild iodine deficiency.

    Science.gov (United States)

    Rendina, D; De Palma, D; De Filippo, G; De Pascale, F; Muscariello, R; Ippolito, R; Fazio, V; Fiengo, A; Benvenuto, D; Strazzullo, P; Galletti, F

    2015-03-01

    Simple nodular goiter and Hashimoto's thyroiditis are 2 frequent nonmalignant thyroid diseases. Tobacco smoking has detrimental effects on the endocrine system and in particular on thyroid function and morphology. The objective of this cross-sectional study, involving 1800 Caucasian adults from a geographical area with mild iodine deficiency, was to evaluate the relationship between tobacco smoking, smoking cessation, and the prevalence of simple nodular goiter and Hashimoto's thyroiditis. Thyroid status was evaluated by ultrasonic exploration of the neck, measurement of FT3, FT4, TSH, antibodies against thyroid peroxidase and thyroglobulin, and urinary iodine excretion. The fine-needle aspiration biopsy of significant nodules was also performed. Smoking habits were evaluated by a specific questionnaire and the calculation of number of pack years. Both current and previous smokers showed an increased risk of simple nodular goiter compared to never smokers after adjustment for potential confounders and known goitrogen factors. Interestingly, the simple nodular goiter risk was similar for never smokers and for previous smokers declaring a time since cessation of smoking for more than 69 months. Smoking habit was not associated to an increased risk of Hashimoto's thyroiditis.Smoking appears to be an independent risk factor for simple nodular goiter but not for Hashimoto's thyroiditis in an area with mild iodine deficiency. A prolonged withdrawal of smoking dramatically reduces the risk of simple nodular goiter occurrence.

  2. 多层螺旋CT(MSCT)在异位阑尾炎诊断中的临床价值%Value of Multi-slice Spiral CT in the Diagnosis of Heterotopia Appendicitis

    Institute of Scientific and Technical Information of China (English)

    裴守科

    2015-01-01

    目的探讨MSCT (多层螺旋CT)超薄层扫描和后处理技术在异位阑尾炎诊断中的临床价值。方法18例异位阑尾炎患者行MSCT,并经计算机后处理工作站行多平面重组(Multiplanar reconstruction,MPR)、曲面重组(Curved planar reformation,CPR),回顾性分析其类型,对异位阑尾炎CT表现进行分析、总结,并与手术及病理结果对照。结果18例患者中高位肝下阑尾5例,低位阑尾7例,盲肠后腹膜外阑尾(腰部阑尾)2例,左下腹位阑尾4例。结论 MSCT超薄层扫描及后处理技术可以多方位显示异位阑尾解剖关系及病变周边情况,提高对异位阑尾炎术前诊断准确率。%Objective To evaluate the clinical value of Multi-slice spiral CT (MSCT) in the diagnosis of Heterotopia Appendicitis. Methods 18 patients with Heterotopia Appendicitis underwent preoperative contrast-enhanced MSCT.Images were transfer ed to the workstation and then processed with multiplanar reconstruction (MPR),curved planar reformation (CPR).CT manifestations were analysed and compared with surgical and pathological findings. Results 18 patients with Heterotopia Appendicitis , 5 have under liver high Appendix ,and 7 have low Appendix, 2 for waist Appendix, and 4 for the bot om left of abdomen Appendix. Conclusion MSCT and MPR/CPR can provide an advantage of showing the appendix multi-directional y that can improve the diagnosis accuracy of Heterotopia Appendicitis .

  3. 肝脏局灶性结节增生的诊断和治疗%Diagnosis and treatment for focal nodular hyperplasia of the liver

    Institute of Scientific and Technical Information of China (English)

    李涛; 朱继业; 王福顺; 冷希圣

    2016-01-01

    目的 探讨肝脏局灶性结节增生(focal nodular hyperplasis,FNH)的临床诊断和治疗方法.方法 回顾性分析36例FNH患者的临床资料.所有患者均行血清学和影像学检查.对于诊断不明确、有明显临床症状者以及虽明确诊断FNH但病灶进行性增大者行相应的手术治疗.确诊为FNH无明显临床症状者随诊观察.结果 36例患者中男22例,女14例.29例患者无明显临床症状.33例患者肝功能正常,HBsAg阳性1例.所有患者肿瘤标志物均正常.术前B超检查均未明确诊断.术前CT检查10例,诊断FNH 4例.术前MRI检查12例,诊断FNH 7例.CT联合MRI检查14例,诊断FNH 10例.手术切除30例,B超引导下经皮射频消融治疗2例,术后随访14 ~ 72个月无复发.4例患者保守治疗,定期影像学观察,随访3 ~ 22个月,病灶无明显增大. 结论 FNH临床表现无特异性.联合CT和MRI检查有助于明确诊断.对于诊断不明确、有明显临床症状者需手术治疗,射频消融是一种疗效肯定的微创治疗方法.FNH预后良好.%Objective To investigate the diagnosis and management of focal nodular hyperplasis (FNH).Methods Clinical data of 36 FNH patients who were admitted to the Peking University People's Hospital from February 2009 to August 2015 were retrospectively analyzed.All the patients received serological and imaging examinations.Appropriate surgical treatment was done on symptomatic patients and those in which diagnosis was established but lesions progressly enlarged.Conservative treatment was done on FNH confirmed patients without symptoms.Results Of the 36 patients,22 were male and 14 were female.29 patients had no obvious clinical symptoms.The liver function was normal in 33 patients,HBsAg positive in 1 case.Serum tumor markers were normal in all patients.B ultrasound made no identification of FNH in all patients.CT was done in 10 cases,and FNH was suggested in 4 cases.MRI done on 12 cases and the diagnosis of FNH was made in

  4. Early hepatocellular carcinoma with high-grade atypia in small vaguely nodular lesions.

    Science.gov (United States)

    Ojima, Hidenori; Masugi, Yohei; Tsujikawa, Hanako; Emoto, Katsura; Fujii-Nishimura, Yoko; Hatano, Mami; Kawaida, Miho; Itano, Osamu; Kitagawa, Yuko; Sakamoto, Michiie

    2016-04-01

    Multistep hepatocarcinogenesis progresses from dysplastic nodules to early hepatocellular carcinoma (eHCC) and to advanced HCC. The aim of the present study was to investigate the detailed histopathological features of eHCC. We investigated 66 small vaguely nodular lesions resected from 40 patients. The degree of cellular and structural atypia and stromal invasion were assessed. The immunohistochemical expression of HCC-related markers adenylate cyclase-associated protein 2 (CAP2), heat shock protein 70 (HSP70), Bmi-1, CD34 and h-caldesmon were evaluated. Of the 66 nodules, 10 were diagnosed as low-grade dysplastic nodules (LGDN), 10 as high-grade dysplastic nodules (HGDN) and 46 as eHCC. Among the 46 eHCC, 18 nodules (39.1%) showed marked stromal invasion and/or the presence of the scirrhous component and were subclassified as high-grade eHCC (HGeHCC). The remaining 28 eHCC, which lacked these features, were subclassified as low-grade eHCC (LGeHCC) and were examined further. HGeHCC showed high levels of cellular and structural atypia and large tumor size. The immunohistochemical expression of CAP2 and the area of sinusoidal vascularization showed increases from LGDN to HGeHCC. The density of arterial tumor vessels was high in HGeHCC compared with other nodule types. Cluster analysis of these parameters subclassified 65 nodules into HGeHCC-dominant, LGeHCC and HGDN-dominant, and LGDN-dominant groups. These results indicate the increased malignant potential of HGeHCC and suggest that it is already a transitional stage to advanced HCC. We consider that our grading classification system may be valuable for considering treatment strategies for eHCC around 2 cm in diameter.

  5. Differentially expressed genes between solitary large hepatocellular carcinoma and nodular hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    Lian-Yue Yang; Wei Wang; Ji-Xiang Peng; Jie-Quan Yang; Gen-Wen Huang

    2004-01-01

    AIM: To study the difference in gene expression between solitary large hepatocellular carcinoma (SLHCC) and nodular hepatocellular carcinoma (NHCC).METHODS: Polymerase chain reaction (PCR) products of 8464 human genes were spotted on a chip in array. DNAs were then fixed on a glass plate. Total RNA was isolated from freshly excised human SLHCC (n=7) and NHCC (n=15)tissues, and was reversely transcribed to cDNAs with the incorporation of fluorescent dUTP for preparation of hybridization probes. The mixed probes were then hybridized to the cDNA microarray. After highly stringent washing,cDNA microarray was scanned for the fluorescent signals to display the difference between the two kinds of HCC. In addition, the expression of RhoC and protocadherin LKC was also detected with the reverse transcriptase polymerase chain reaction (RT-PCR) method.RESULTS: Among the 8 464 human genes, 668 (7.89%)genes were expressed differentially at the mRNA levels between SLHCC and NHCC. Three hundred and fifty five (4.19%) genes, including protocadherin LKC, were upregulated, whereas 313 (3.70%) genes, including RhoC,were down-regulated. The mRNA expression levels of RhoC and protocadherin LKCwere confirmed by RT-PCR. Analysis of differentially expressed genes confirmed that our molecular data obtained by cDNA microarray were consistent with the published biochemical and clinical observations of SLHCC and NHCC.CONCLUSION: cDNA microarray is an effective technique in screening the difference in gene expression between SLHCC and NHCC. Many of these differentially expressed genes are involved in the invasion and metastasis of HCC.Further analysis of these genes will help to understand the different molecular mechanisms of SLHCC and NHCC.

  6. Trisomy 1 and 8 occur frequently in hepatocellular carcinoma but not in liver cell adenoma and focal nodular hyperplasia. A fluorescence in situ hybridization study.

    Science.gov (United States)

    Nasarek, A; Werner, M; Nolte, M; Klempnauer, J; Georgii, A

    1995-01-01

    Conventional cytogenetic studies revealed gains and structural aberrations of chromosome 1 to be the most consistent chromosomal aberrations in hepatocellular carcinoma (HCC). We investigated touch preparations of eight HCC, five cholangiocellular carcinomas (CCC), five liver cell adenomas (LCA), four focal nodular hyperplasias (FNH) as well as nine specimens of normal liver tissue using fluorescence in situ hybridization (FISH) with centromere specific probes for chromosomes 1 and 8. Polysomies of chromosome 1, especially trisomy 1, were found in five of eight HCC and four of five CCC but in no normal liver tissue or benign tumour. Only three of seven cases of HCC revealed trisomy 8 whereas the five benign liver tumours and all normal liver tissues examined had disomy 8. Our results confirm conventional cytogenetic findings in terms of chromosome 1 aberrations in HCC although they are not specific for these types of malignant liver tumours. Since alpha-satellite probes were used in our study, only gains or losses including the centromeric regions of the chromosomes 1 and 8 could be detected. Nevertheless, our findings suggest that FISH may help in the differential diagnosis of malignant versus benign neoplasms of the liver.

  7. Focal nodular hyperplasia of the liver: composition of the extracellular matrix and expression of cell-cell and cell-matrix adhesion molecules.

    Science.gov (United States)

    Scoazec, J Y; Flejou, J F; D'Errico, A; Couvelard, A; Kozyraki, R; Fiorentino, M; Grigioni, W F; Feldmann, G

    1995-10-01

    We studied by immunohistochemistry 25 cases of focal nodular hyperplasia (FNH) to evaluate the composition of the extracellular matrix and the expression and distribution of endothelial cell-cell adhesion molecules and integrin receptors. The extracellular matrix of FNH retained the overall organization of that of normal liver. The matrix of central scars resembled that of portal tracts. The main difference was the presence of large vitronectin deposits, which might indicate the existence of local hemodynamic disturbances. The matrix lining the sinusoid-like vessels running in the hyperplastic parenchyma retained characteristic features of the normal perisinusoidal matrix, such as the presence of tenascin. In the zone surrounding the central scars, it contained large amounts of laminin, von Willebrand factor, and thrombospondin, suggesting the development of perisinusoidal fibrosis. Laminin deposition was accompanied by the induction of cell-cell adhesion molecules on adjacent endothelial cells and by the up-regulation of specific integrin receptors on both hepatocytes and sinusoidal endothelial cells. In conclusion, our study: (1) reinforces the hypothesis that FNH is merely a hyperplastic response of liver parenchyma to local vascular abnormalities, and (2) shows that the lesions of perisinusoidal fibrosis associated with FNH are accompanied by the induction of integrin receptors on hepatocytes and sinusoidal endothelial cells.

  8. Combined hepatocellular-cholangiocarcinoma in a patient with Abernethy malformation and tetralogy of Fallot: A case report.

    Science.gov (United States)

    Happaerts, Sofie; Foucault, Amélie; Billiard, Jean Sébastien; Nguyen, Bich; Vandenbroucke-Menu, Franck

    2016-11-01

    Abernethy malformation is a rare congenital anomaly of the portal vein where the portal blood bypasses the liver. We report the first case of a patient with Abernethy malformation and tetralogy of Fallot associated with nodular regenerative hyperplasia and focal nodular hyperplasia (FNH), which finally evolved to a giant hepatocellular-cholangiocarcinoma (HCC-CC) of the liver, successfully resected. (Hepatology 2016;64:1800-1802). © 2016 by the American Association for the Study of Liver Diseases.

  9. Primary diffuse tracheobrochial amyloidosis: case report

    Energy Technology Data Exchange (ETDEWEB)

    Oezer, Caner E-mail: mnduce@hotmail.com; Nass Duce, Meltem; Yildiz, Altan; Apaydin, F. Demir; Egilmez, Hulusi; Arpaci, Taner

    2002-10-01

    Respiratory amyloidosis is a rare disease that occurs in three forms: tracheobronchial, nodular parenchymal and diffuse parenchymal involvement. Tracheobronchial amyloidosis is characterized by focal or diffuse deposition of amyloid in the submucosa of the trachea and proximal bronchi. Herein, we report a case of diffuse tracheobronchial amyloidosis with plain radiography and thorax computed tomography findings.

  10. Contrast-enhanced ultrasonography in nodular splenomegaly associated with type B Niemann-Pick disease: an atypical hemangioma enhancement pattern.

    Science.gov (United States)

    Benedetti, E; Proietti, A; Miccoli, P; Basolo, F; Ciancia, E; Erba, P A; Galimberti, S; Orsitto, E; Petrini, M

    2009-09-01

    Sommario INTRODUZIONE: La malattia di Niemann-Pick (NPD) tipo A e B è una patologia da accumulo di lipidi. Il tipo A è un disordine fatale dell'infanzia. Il tipo B è una forma non-neuronopatica ossevata sia nei bambini che negli adulti con possibile riscontro di epatomegalia e/o splenomegalia (nodulare) durante un esame ecografico. Il tipo C dipende da un difetto nel trasporto del colesterolo. METODI: Una donna di 21 anni si è presentata al Pronto Soccorso con febbre, faringodinia e dolore al quadrante addominale superiore sinistro. Gli esami ematochimici hanno evidenziato anemia, piastrinopenia, aumento delle AST, ALT, GGT, FA, LDH trigliceridi, colesterolo totale, e ridotto HDL. La PCR per CMV ed EBV era negativa. La radiografia del torace era negativa. L'ecografia transaddominale ha rilevato splenomegalia (>22 cm long axis) con una lesione ipoecogena irregolare subcapsulare al polo superiore compatibile con infarto splenico e la presenza di multiple lesioni nodulari iperecogene con diametro da 1 cm fino a 5. RISULTATI: È stata quindi eseguita una ecografia con mezzo di contrasto con SonoVue (Bracco) che ha confermato la presenza di un infarto splenico. Le lesioni nodulari mostravano un enhancement in fase arteriosa con wash out in fase parenchimatosa tardiva. La F-FDG-PET ha mostrato un uptake nodulare splenico. Nel sospetto di un processo linfoproliferativo è stata eseguita una splenectomia. La diagnosi è stata di NPD tipo B con infarto splenico e le lesioni nodulari sono risulate essere emangiomi. DISCUSSIONE: Concludendo, la CEUS ha confermato la diagnosi e l'estenzione dell'infarto splenico, ma l'enhancement nodulare atipico supportato dalle immagini F-FDG-PET è stato fuorviante, suggerendo l'ipotesi di lesioni linfomatose.

  11. A comparison of microRNA expression profiles from splenic hemangiosarcoma, splenic nodular hyperplasia, and normal spleens of dogs.

    Science.gov (United States)

    Grimes, Janet A; Prasad, Nripesh; Levy, Shawn; Cattley, Russell; Lindley, Stephanie; Boothe, Harry W; Henderson, Ralph A; Smith, Bruce F

    2016-12-03

    Splenic masses are common in older dogs; yet diagnosis preceding splenectomy and histopathology remains elusive. MicroRNAs (miRNAs) are short, non-coding RNAs that play a role in post-transcriptional regulation, and differential expression of miRNAs between normal and tumor tissue has been used to diagnose neoplastic diseases. The objective of this study was to determine differential expression of miRNAs by use of RNA-sequencing in canine spleens that were histologically confirmed as hemangiosarcoma, nodular hyperplasia, or normal. Twenty-two miRNAs were found to be differentially expressed in hemangiosarcoma samples (4 between hemangiosarcoma and both nodular hyperplasia and normal spleen and 18 between hemangiosarcoma and normal spleen only). In particular, mir-26a, mir-126, mir-139, mir-140, mir-150, mir-203, mir-424, mir-503, mir-505, mir-542, mir-30e, mir-33b, mir-365, mir-758, mir-22, and mir-452 are of interest in the pathogenesis of hemangiosarcoma. Findings of this study confirm the hypothesis that miRNA expression profiles are different between canine splenic hemangiosarcoma, nodular hyperplasia, and normal spleens. A large portion of the differentially expressed miRNAs have roles in angiogenesis, with an additional group of miRNAs being dysregulated in vascular disease processes. Two other miRNAs have been implicated in cancer pathways such as PTEN and cell cycle checkpoints. The finding of multiple miRNAs with roles in angiogenesis and vascular disease is important, as hemangiosarcoma is a tumor of endothelial cells, which are driven by angiogenic stimuli. This study shows that miRNA dysregulation is a potential player in the pathogenesis of canine splenic hemangiosarcoma.

  12. Familial isolated primary pigmented nodular adrenocortical disease associated with a novel low penetrance PRKAR1A gene splice site mutation

    DEFF Research Database (Denmark)

    Storr, Helen L; Metherell, Louise A; Dias, Renuka

    2010-01-01

    Primary pigmented nodular adrenocortical disease (PPNAD) is associated with inactivating germline protein kinase A regulatory subunit type 1-alpha (PRKAR1A) mutations and loss of heterozygosity at the 17q22-24 locus in approximately 50% patients. PRKAR1A mutations are observed in both isolated PP...... PPNAD (iPPNAD) and Carney complex (CNC). Most mutations result in a functionally null-allele and exhibit high penetrance. We genotyped members of an extended family for a novel PRKAR1A mutation and undertook detailed phenotyping for CNC in the affected individuals....

  13. Nodular hepatocellular carcinoma : contrast enhancement patterns on three - phase spiral CT

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hak Jong; Choi, Byung Ihn; Han, Joon Koo; Kim, Seung Hyup; Kim, Woo Sun; Kim, Tae Kyung; Choi, Dae Seop [Seoul National Univ. College of Medicine, Seoul (Korea, Republic of)

    1996-09-01

    To evaluate contrast enhancement patterns of nodular hepatocellular carcinomas (HCCs) on three-phase spiral CT. A retrospective analysis of contrast enhancement patterns was performed in 48 patients with HCC. Three-phase dynamic CT images of hepatic arterial dominant phase, portal dominant phase, and delayed phase were obtained at 30, 65 and 360 seconds after the initiation of injection of contrast material, respectively. Iodized-oil CT was performed two weeks after angiography and infusion of iodized-oil. Masses were divided into three groups, according to size ; 1-20mm (n=34), 21-40mm (n=26), and over 40mm (n=19). Contrast enhancement patterns of tumors compared with attenuation of surrounding liver parenchyma, were cheracterized as one of four types, as follows : high, iso, low and mixed attenuation. Seventy-three of 79 HCC nodules detected on iodized-oil CT (92%) were detected on three-phase spiral CT. In the 1-20mm group, masses showed high-attenuation in the arterial dominant phase(19/34, 55.9%), and iso-attenuation in the portal dominant phase(16/34, 47.1 %) and delayed phase(18/34, 52.9%). In the 21-40mm group, masses showed high-attenuation in the arterial dominant phase(21/26, 80.8 %), low-attenuation in the portal dominant phase(13/26, 50%) and delayed phase(21/26, 80.8 %). In the over 40m group, the masses showed mixed-attenuation in the arterial dominant phase(9/19, 47.4%), low-attenuation in the portal dominant phase(12/19, 63.2%), and delayed phase(16/19, 84.2 %). The most common enhancement pattern was high(arterial dominant)-iso(portal dominant)-iso(delayed) in the 1-20 mm group (8/34, 23.5 %), high-low-low in the group 21-40 mm (8/26, 30.8%), and mixed-low-low in the over 40mm group (5/19, 26.3%). Hepatocellular carcinomas showed variable enhancing patterns according to the size of the tumor on three-phase spiral CT. Understanding these enhancing characteristics of HCCs on three-phase spiral CT may be helpful in their diagnosis.

  14. Management of Nodular Lymphocyte Predominant Hodgkin Lymphoma in the Modern Era

    Energy Technology Data Exchange (ETDEWEB)

    King, Martin T., E-mail: mking1@stanford.edu [Department of Radiation Oncology, Stanford Cancer Institute, Stanford, California (United States); Donaldson, Sarah S. [Department of Radiation Oncology, Stanford Cancer Institute, Stanford, California (United States); Link, Michael P. [Department of Pediatrics, Stanford Cancer Institute, Stanford, California (United States); Natkunam, Yasodha [Department of Pathology, Stanford Cancer Institute, Stanford, California (United States); Advani, Ranjana H. [Department of Medicine, Stanford Cancer Institute, Stanford, California (United States); Hoppe, Richard T. [Department of Radiation Oncology, Stanford Cancer Institute, Stanford, California (United States)

    2015-05-01

    Purpose: To analyze treatment outcomes for nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) at a single institution. Patients and Methods: Patients with newly diagnosed NLPHL between 1996 and 2013 were reviewed retrospectively. Patients treated before 1996 were excluded because the majority received extended field radiation therapy (RT) alone. Results: Fifty-five patients (22 ≤ 21 years old) were identified. The median follow-up time was 6.8 years. Among 37 patients with limited-stage (I-II) disease, treatments included involved field RT at a median dose of 36 Gy (n=9), rituximab monotherapy (n=9), observation (n=3), and response-adaptive therapy (n=16), in which the RT dose was reduced from 25.5 Gy to 15 Gy or was eliminated based on interim imaging after chemotherapy. The 5-year progression-free survival (PFS) was 76.4% (95% confidence interval [CI], 63.1-92.4). Nine patients experienced progression, including 5 receiving rituximab, 2 undergoing observation, and 2 receiving response-adaptive therapy. Rituximab was associated with an inferior PFS compared with RT alone (P=.02). The difference in PFS between response-adaptive therapy and RT alone was not statistically significant (P=.39). Among 18 patients with advanced-stage (III-IV) disease, treatments included chemotherapy alone (n=3), combined modality therapy (CMT) (n=2), response-adaptive therapy (n=2), rituximab (n=7), and observation (n=4). The 5-year PFS was 29.9% (CI, 13.3-67.4). Twelve patients experienced progression, including 1 receiving chemotherapy, 1 receiving CMT, 6 receiving rituximab, and 4 undergoing observation. There was no significant PFS difference between rituximab and non-rituximab therapies (P=.19) within the caveat of small sample sizes. In the entire cohort, 9 patients (3 with limited disease, 6 with advanced disease) experienced large cell transformation (LCT). Seven patients died; of those, 5 died with LCT. Conclusions: For limited disease, response-adaptive therapy

  15. Effect of fatty liver background on contrast-enhanced ultrasonographic appearance of focal nodular hyperplasia

    Institute of Scientific and Technical Information of China (English)

    Li-Wu Lin; Jia-Jia Yang; Xue-Ying Lin; En-Sheng Xue; Yi-Mi He; Shang-Da Gao; Long Yang; Li-Yun Yu

    2007-01-01

    BACKGROUND:Focal nodular hyperplasia (FNH) is increasingly diagnosed as a result of the advances in imaging studies such as contrast-enhanced ultrasonography (CEUS), enhanced computed tomography and magnetic resonance imaging. However, FNH with atypical features can be dififcult to differentiate from other benign and malignant tumors. The aim of this study was to investigate the inlfuence of fatty liver background on the CEUS characteristics of FNH. METHODS:Twenty-six patients with FNH were divided into two groups: group A included 14 patients with fatty liver and group B included 12 patients with normal liver background. Conventional two-dimensional ultrasonography and color Doppler lfow imaging (CDFI) were conducted and followed by real-time dual-frame CEUS. RESULTS:On two-dimensional ultrasonography, hypo-echoic nodules were present in most of the patients in group A (12/14) and hyperechoic nodules in most of those in group B (7/12). The difference in the nodule echotextures between the two groups was statistically signiifcant (P0.05). On CEUS, nodules with a central spoked-wheel-like enhancement pattern in the early arterial phase were observed in 8 patients in group A and those with an eccentric enhancement pattern in the remaining 6 patients. In this group, 3 patients had hypoechoic nodules in the delayed phase. Eleven of the 14 patients in this group were diagnosed accurately with CEUS. In group B, nodules with a rapid central spoked-wheel-like enhancement pattern in the early arterial phase were found in 8 patients by CEUS and those with rapid an eccentric enhancement pattern in 4. The nodules were found to be continuously enhanced in the delayed phase. All of the patients in group B were accurately diagnosed with CEUS. CONCLUSIONS:A FNH nodule on a background of fatty liver may present a hypoechoic pattern on two-dimensional ultrasonography and a hypoechoic wash-out pattern in the delayed phase on CEUS. At this time, punch biopsy is needed for the

  16. Application of Cored-Wire Injection Nodularizing Process in Production of Low-Temperature Nodular Iron Castings%喂丝球化处理法在低温球墨铸铁件生产的应用

    Institute of Scientific and Technical Information of China (English)

    王小伟; 朱浩宇; 张胜; 黄伟; 殷作虎

    2013-01-01

    The advantages of using cored-wire injection nodualrizing process to produce low temperature nodular iron,design of wire injection equipment and treating station were introduced.The mechanical properties requirements,composition control of wind power casting Wikov housing and 1.5 MW hub,as well as their production result by using cored-wire injection process were described,and it was showed thereby,that the cored-wire injection process is a new nodularizing process valuable to be popularized.%介绍了喂丝法生产低温球铁的主要优点、喂丝设备和处理站的设计.叙述风电铸件Wikov箱体和1.5 MW轮毂的力学性能要求、成分控制以及用喂丝法生产的结果,说明喂丝法是一种值得推广的球化处理新工艺.

  17. Compare the differences of PICC catheter heterotopias in the traditional turning neck method with finger-pressing method%传统转颈法和指压法防治PICC导管异位的效果对比

    Institute of Scientific and Technical Information of China (English)

    鲁华; 王伟; 叶佳; 郭维娜

    2016-01-01

    Objective To compare the effects of PICC catheter heterotopias in the traditional turning neck method with finger-pressing method. Methods From October 2010 to October 2014, 596 patients were randomly divided into two groups, 296 cases in observation group using traditional turning neck method, and the other 300 patients in control group using finger-pressing method. We compared the differences between these two groups by the operation time for subclavian vena to brachiocephalica and rate of ectopic catheter tip. Results The incidences of ectopic catheter tip were 15. 00% and 5. 41% in control group and observation group, which was lower in observation group comparing with control group (χ2 =14. 929, P <0. 05). The operation time was (16.94±3.03)sand(7.24±4.70)sincontrolgroupandobservationgroup(t=29.900,P<0.01). Conclusions Finger-pressing method decreases the rate of ectopic catheter tip and operation time of PICC catheter technique.%目的:探讨PICC置管过程中传统转颈法与指压法防治导管异位的效果,为临床护理提供依据。方法将2010年10月—2014年10月拟行留置PICC的596例患者随机分为观察组( n=296)和对照组(n=300),观察组以助手通过指压法阻断颈部静脉,对照组按传统的转颈法阻止导管进入颈静脉。比较两组患者导管通过锁骨下静脉入头臂静脉的操作时间和导管尖端异位率。结果对照组异位率为15.00%,观察组异位率为5.41%,观察组导管异位率低于对照组,两组比较差异有统计学意义(χ2=14.929,P<0.05)。对照组导管通过锁骨下静脉入头臂静脉的操作时间为(16.94±3.03) s,观察组为(7.24±4.70)s,两组比较差异有统计学意义(t=29.900,P<0.01)。结论在PICC置管过程中,指压法能更有效地降低导管异位率,有效地缩短操作时间。

  18. Comprehensive studies of IR to UV light intensification by nodular defects in HfO2/SiO2 multilayer mirrors

    Science.gov (United States)

    Smalakys, Linas; Batavičiūtė, Gintarė; Pupka, Egidijus; Melninkaitis, Andrius

    2014-10-01

    Nodular defects tend to limit laser-induced damage threshold (LIDT) of multilayer dielectric coatings frequently used for laser applications. Cross-sections of localized damage morphologies correlate well with light intensifi- cation patterns caused by defect geometries. In vast majority of studies electric field enhancement in nodular defects was investigated for infrared spectral region. In this work theoretical analysis has been extended for IR - UV range. Light intensification in HfO2/SiO2 multilayer mirror coating was studied numerically. The analysis of obtained results indicates that phenomena is very sensitive to almost every investigated parameter. It was also found that field enhancement effect can be reached within distinct material layers (either of low or high refractive index). The discussion and insights complementing existing knowledge on nodular defects were made.

  19. 孤立结节型肺隐球菌病的多排螺旋CT表现%Clinical Features of Pulmonary Cryptococcosis of Solitary Nodular Type as Manifested by Multi-spiral Computed Tomography

    Institute of Scientific and Technical Information of China (English)

    邢维明; 左玉强; 贾丽萍; 苌永利

    2016-01-01

    目的:探讨肺内孤立结节型肺隐球菌病的多排螺旋CT表现,以提高其诊断正确率。方法回顾性分析18例经病理证实的孤立结节型肺隐球菌病患者的螺旋CT表现。结果18例病变中,有13例位于胸膜下,12例位于肺下叶;CT表现为类圆形结节16例、空气支气管征15例、血管集束征8例、宽基底与胸膜相连7例、晕征6例、胸膜反应5例、胸膜凹陷2例、毛刺征4例、分叶征2例。结论孤立结节型肺隐球菌病的多排螺旋CT表现有一定的特征性,认真分析其征象有助于提高该病的诊断正确率。%Objective To investigate the clinical manifestations of pulmonary crytococcosis (PC) of solitary nodular type as illustrated by multi-spiral computed tomography so as to improve the diagnostic accuracy.Methods The CT images of 18 patients diagnosed with pulmonary crytococcosis were reviewed retrospectively, all the diagnoses were pathologically conifrmed.Results Among the 18 cases, 13 nodules were located in subpleural regions and 12 nodules were located in lower lobes. CT images indicated that circular nodules were found in 16 cases, air bronchogram was found in 15 cases, vascular convergence was found in 8 cases, 7 cases clinged to pleura with wide basement, halo sign was found in 6 cases, pleural reaction was found in 5 cases, pleural indentation was found in 2 cases, spicule sign was found in 4 cases, slender spiculation was found in 2 cases.Conclusion As manifested by the multi-spiral computed tomography imaging, the clinical features of pulmonary cryptococcosis of solitary nodular type had certain characteristic idiosyncrasy. Careful analysis of CT imaging of the solitary PC can help improve the diagnostic accuracy.

  20. Arrival time parametric imaging using Sonazoid-enhanced ultrasonography is useful for the detection of spoke-wheel patterns of focal nodular hyperplasia smaller than 3 cm

    Science.gov (United States)

    WAKUI, NORITAKA; TAKAYAMA, RYUJI; KAMIYAMA, NAOHISA; KOBAYASHI, KOJIRO; MATSUI, DAIGO; MATSUKIYO, YASUSHI; KANEKAWA, TAKENORI; IKEHARA, TAKASHI; ISHII, KOJI; SUMINO, YASUKIYO

    2013-01-01

    It is considered difficult to make a definitive diagnosis of focal nodular hyperplasia (FNH) of <3 cm when using conventional diagnostic imaging modalities. Typical FNH imaging findings are: i) central scar formation, ii) nutrient vessels extending radially from the center and iii) the presence of Kupffer cells. In a clinical setting, identification of a spoke-wheel pattern formed by nutrient vessels extending radially is a key feature in the diagnosis of FNH. In this study, we investigated the detection rate of spoke-wheel patterns of FNH <3 cm using arrival time parametric imaging (At-PI) technology with Sonazoid-enhanced ultrasonography (US). Five patients with FNH <3 cm who had undergone Sonazoid-enhanced US at the Toho University Omori Medical Center between February 2008 and March 2009 were included in the study. The mean tumor diameter was 20.2±7.2 mm. Lesions were enhanced with 0.5 ml Sonazoid US contrast agent and a video of the procedure was saved and used for At-PI analysis of contrast agent dynamics in FNH. Three ultrasonographic specialists examined the images and made a diagnosis of FNH based on the findings of spoke-wheel patterns. Similarly, micro-flow imaging (MFI) was performed to evaluate the contrast agent dynamics in FNH. Using MFI, FNH was diagnosed in 3 of the 5 cases by the three specialists, whereas At-PI enabled the identification of spoke-wheel patterns in all 5 cases. At-PI using Sonazoid-enhanced US is superior for detecting spoke-wheel patterns of FNH <3 cm. PMID:23837029

  1. Active Mg Estimation Using Thermal Analysis: A Rapid Method to Control Nodularity in Ductile Cast Iron Production

    Science.gov (United States)

    Suárez, Ramon; Sertucha, Jon; Larrañaga, Pello; Lacaze, Jacques

    2016-10-01

    Appropriate nodularity in ductile iron castings is strongly associated with the presence of high enough not combined Mg dissolved in the melt to cast. However, the residual Mg which is commonly measured for production control accounts for both dissolved Mg and Mg combined as oxides and sulfides. To account for the uncertainties associated with such a control, it is quite usual to over treat the melt with the risk of porosity appearance. A new methodology based on thermal analysis has been developed in the present work so as to estimate the amount of free Mg dissolved in the melt ready for pouring. A combination of Te mixture and a new "reactive mixture" composed of sulfur plus a commercial inoculant has been prepared for this purpose. This reactive mixture is able to transform the magnesium remaining dissolved in the melt to combined forms of this element. Experiments performed both during start of production (when Mg overtreatment is usual) and during normal mass production indicate that important variations of free Mg occur without relevant changes in residual Mg content as determined by spectrometry. The method developed in the present work has shown to be highly effective to detect those melt batches where active Mg content is not high enough for guaranteeing a correct nodularity of castings. Selection of proper active Mg thresholds and a correct inoculation process are critical to avoid "false"-negative results when using this new method.

  2. A Novel PRKAR1A Mutation Identified in a Patient with Isolated Primary Pigmented Nodular Adrenocortical Disease

    Directory of Open Access Journals (Sweden)

    Sira Korpaisarn

    2017-08-01

    Full Text Available Primary pigmented nodular adrenocortical disease (PPNAD is a rare cause of Cushing syndrome, especially the isolated form without Carney complex, associated with germline mutations in PRKAR1A, the protein kinase A regulatory subunit type 1 alpha gene. We report a 31-year-old female who presented with secondary amenorrhea, cushingoid appearance, and hypertension without Carney complex. Biochemical laboratory examinations confirmed the ACTH-independent adrenal Cushing syndrome with negative Liddle test. A small right adrenal adenoma of 0.8 cm was shown on computed tomography while magnetic resonance imaging revealed nodularity of both adrenal glands. The histological report confirmed PPNAD using laparoscopic right adrenalectomy, and subsequent left adrenalectomy was performed 6 months later. She had inherited heterozygosity of a novel germline mutation of the PRKAR1A gene (g.114213T>G or c.709-5T>G. This splice site mutation results in exon 8 skipping. Her father carrying the same mutation had no clinical features of either PPNAD or Carney complex. This novel PRKAR1A gene mutation, c.709-5T>G, is reported here for the first time manifesting as an incomplete clinical expression of the isolated form of PPNAD and being inherited with low penetrance unlike other inherited mutations of the Carney complex which have a penetrance of almost 100%.

  3. Comportamiento del hierro nodular austemperizado en condiciones de corrosión y desgaste // Behavior of austempered ductile iron under wear and corrosion conditions

    Directory of Open Access Journals (Sweden)

    L. Goyos Pérez

    1999-07-01

    Full Text Available Los hierros nodulares en general y los austemperizados en particular han sido usados con cada vez mayor frecuencia debido asus relevantes propiedades mecánicas en comparación con su costo.En el presente trabajo se valora el comportamiento del hierro nodular ante el trabajo en condiciones de desgaste y corrosión,luego de ser sometido a diferentes tratamientos de austemperizado.Fueron usados un hierro nodular aleado con níquel y molibdeno y otro no aleado. Ambos hierros fueron sometidos a diferentestratamientos de austemperización con mantenimientos isotérmicos a temperaturas entre 250°C y 425°C por tiempos entre 15 y180 minutos.Las muestras tratadas fueron sometidas a ensayos de desgaste por fricción en condiciones no lubricadas determinando laspendientes de desgaste uniforme para cada caso. La resistencia a la corrosión fue determinada mediante el métodopotenciométrico usando como medio el jugo de caña sintético.A partir de los resultados obtenidos se valora la influencia de los diferentes tratamientos sobre las propiedades estudiadas y sedeterminan los más efectivos desde el punto de vista técnico económico.Palabras claves: Hierro nodular, corrosión, desgaste, austemperizado.____________________________________________________________________________AbstractNodular irons and particularly austempered ductile iron has been used more and more due to their excellent mechanicalproperties in comparison with their cost.Presently work deals on behavior of nodular iron working under wear and corrosion conditions, after being submitted todifferent austempered treatments.A nodular iron alloyed with nickel and molybdenum were used as well as a not alloyed one. Both irons were treated underdifferent austempered treatment combinations using isothermal maintenance to temperatures between 250°C and 425°C andspending times between 15 and 180 minutes.Samples were submitted to non-lubricated wear using a “pin on disk” method evaluating the

  4. Aicardi syndrome: A report of five Indian cases

    Directory of Open Access Journals (Sweden)

    Banerjee T

    2006-01-01

    Full Text Available Five Indian cases of Aicardi syndrome, aged 1-13 years and all with the classic triad of infantile spasm, corpus callosal agenesis and chorioretinal lacunae, were presented. The purpose of this report was to demonstrate the clinical, electroencephalographic (EEG and radiological spectrum and the treatment outcome of this disorder among the Indians. None of the patient had any family history of similar illness. All had profound psychomotor impairment with no meaningful speech development. There were microphthalmia in 2, optic disc coloboma in 1, interhemispheric cyst in 1, periventricular heterotopia in 2 and thoracolumbar kyphoscoliosis in 2 cases. They all had early onset epilepsy and there were multiple types of seizures. Two cases (40% had the characteristic dissociated burst-suppression pattern in EEG. Two cases whose antiepileptic medications included vigabatrin had complete control of seizure.

  5. Application of Y-Base Heavy RE-Mg Nodularizing Alloy-Cored Wire%钇基重稀土镁球化包芯线的应用

    Institute of Scientific and Technical Information of China (English)

    胡玲海; 董成玉; 杨宇鹏; 刘燕平

    2011-01-01

    详细介绍了喂线处理工艺和包芯线的规格,采用钇基重稀士镁球化包芯线生产汽车加重桥壳球铁铸件和风电铸件,试验结果表明:(1)钇基重稀土高镁球化包芯线应用于大断面球墨铸铁件生产,具有较强的抗球化衰退能力,能保证材料的质量要求;(2)喂线法球化处理工艺是保证球铁材料质量、改善作业环境的良好工艺.%A detailed introduction was given to the cored wire injection nodularizing process and the specifications of the cored wire. The Y-base heavy rare earth-containing RE-Mg-Si-Fe nodularizing alloy was used to produce heavy automotive bridge housing and wind power nodular iron castings. The test results showed: (1 )when being used for production of heavy section nodular iron castings, the Y-base heavy RE-Mg-Si-Fe nodularizing alloy has relatively strong anti-nodularizing degeneration capacity so it could ensure the casting material quality requirement;( 2 )Cored wire injection nodularizing process is a excellent process which could ensure the nodular iron casting quality.

  6. Thyroid hormone-dependent formation of a subcortical band heterotopia (SBH) in the neonatal brain is not exacerbated under conditions of low dietary iron (FeD).

    Science.gov (United States)

    Spring, S R; Bastian, T W; Wang, Y; Kosian, P; Anderson, G W; Gilbert, M E

    2016-01-01

    Thyroid hormones (TH) are critical for brain development and insufficiencies can lead to structural abnormalities in specific brain regions. Administration of the goitrogen propylthiouracil (PTU) reduces TH production by inhibiting thyroperoxidase (TPO), an enzyme that oxidizes iodide for the synthesis of TH. TPO activity is iron (Fe)-dependent and dietary iron deficiency (FeD) also reduces circulating levels of TH. We have previously shown that modest degrees of TH insufficiency induced in pregnant rat dams alters the expression of TH-responsive genes in the cortex and hippocampus of the neonate, and results in the formation of a subcortical band heterotopia (SBH) in the corpus callosum (Royland et al., 2008, Bastian et al., 2014, Gilbert et al., 2014). The present experiment investigated if FeD alone was sufficient to induce a SBH or if FeD would augment SBH formation at lower doses of PTU. One set of pregnant rats was administered 0, 1, 3, or 10ppm of PTU via drinking water starting on gestational day (GD) 6. FeD was induced in a 2nd set of dams beginning on GD2. A third set of dams received the FeD diet from GD2 paired with either 1ppm or 3ppm PTU beginning on GD6. All treatments continued until the time of sacrifice. On PN18, one female pup from each litter was sacrificed and the brain examined for SBH. We observed lower maternal, PN2 and PN18 pup serum T4 in response to PTU. FeD reduced serum T4 in pups on PN16, but did not affect serum T4 in dams or PN2 pups. Neither did FeD in combination with PTU alter T4 levels in dams on PN18 or pups on PN2 compared to PTU treatment alone. By PN16, however more severe T4 reductions were observed in pups when FeD was combined with PTU. SBH increased with increasing dosage of PTU, but counter to our hypothesis, no SBH was detected in the offspring of FeD dams. As such, T4 levels in dams and newborn pups rather than older neonates appear to be a better predictor SBH associated with TH insufficiency. These data indirectly

  7. Influencia de los factores microestructurales en la resistencia al desgaste por deslizamiento de las fundiciones nodulares austemperadas

    Directory of Open Access Journals (Sweden)

    C. J. Diez Cicero

    2008-09-01

    Full Text Available Entre los materiales metálicos de mayor demanda, el hierro dúctil con grafito esferoidal o nodular ocupa en la actualidad uno de los lugares más importantes entre los hierros fundidos de alta resistencia. Desde hace unos veinticinco años la introducción del hierro nodular austemperado significó de hecho una revolución en el campo de las aleaciones ferrosas. En el presente trabajo se realiza un estudio de la influencia del conteo de nódulos de grafito del hierro nodular en el proceso de austemperado, a partir de las características de las estructuras obtenidas, por la variación de la cantidad de nódulos de grafito y de las variables de tratamiento térmico. Dichas estructuras son sometidas a la acción del desgaste, en este caso a un desgaste por deslizamiento mediante un ensayo típico disco-zapata. Con los resultados obtenidos, se realiza un análisis estadístico de la influencia del conteo de nódulos en dichas propiedades y de las causas de este comportamiento, tomando en consideración la interrelación del conteo de nódulos con las variables de tratamiento térmico utilizadas en las muestras ensayadas y su incidencia en el mecanismo de desgaste.A study about the influence of the graphite nodules quantity and some heat treatment parameters in the characteristic of cast ductile iron is presented. Experimental investigation of wear resistance by sliding is applied to specimens tested of austempered ductile irons using a test machine based in the disc- plate system. Statistical analysis about the influence of the graphite nodule quantity in the wear resistance properties, so as well as, the causes of this behaviour taking into account the graphite nodule count and some heat treatment variables is don.

  8. Nodular lymphocyte predominant hodgkin lymphoma and T cell/histiocyte rich large B cell lymphoma--endpoints of a spectrum of one disease?

    Directory of Open Access Journals (Sweden)

    Sylvia Hartmann

    Full Text Available In contrast to the commonly indolent clinical behavior of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL, T cell/histiocyte rich large B cell lymphoma (THRLBCL is frequently diagnosed in advanced clinical stages and has a poor prognosis. Besides the different clinical presentations of these lymphoma entities, there are variants of NLPHL with considerable histopathologic overlap compared to THRLBCL. Especially THRLBCL-like NLPHL, a diffuse form of NLPHL, often presents a histopathologic pattern similar to THRLBCL, suggesting a close relationship between both lymphoma entities. To corroborate this hypothesis, we performed gene expression profiling of microdissected tumor cells of NLPHL, THRLBCL-like NLPHL and THRLBCL. In unsupervised analyses, the lymphomas did not cluster according to their entity. Moreover, even in supervised analyses, very few consistently differentially expressed transcripts were found, and for these genes the extent of differential expression was only moderate. Hence, there are no clear and consistent differences in the gene expression of the tumor cells of NLPHL, THRLBCL-like NLPHL and THRLBCL. Based on the gene expression studies, we identified BAT3/BAG6, HIGD1A, and FAT10/UBD as immunohistochemical markers expressed in the tumor cells of all three lymphomas. Characterization of the tumor microenvironment for infiltrating T cells and histiocytes revealed significant differences in the cellular composition between typical NLPHL and THRLBCL cases. However, THRLBCL-like NLPHL presented a histopathologic pattern more related to THRLBCL than NLPHL. In conclusion, NLPHL and THRLBCL may represent a spectrum of the same disease. The different clinical behavior of these lymphomas may be strongly influenced by differences in the lymphoma microenvironment, possibly related to the immune status of the patient at the timepoint of diagnosis.

  9. A 20-year population-based study on the epidemiology, clinical features, treatment, and outcome of nodular lymphocyte predominant Hodgkin lymphoma.

    Science.gov (United States)

    Strobbe, L; Valke, L L F G; Diets, I J; van den Brand, M; Aben, K; Raemaekers, J M M; Hebeda, K M; van Krieken, J H J M

    2016-02-01

    Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a subtype of Hodgkin lymphoma characterized by a unique clinical and histological presentation. Because of the rare nature of this disease, few large-scale studies are available. We conducted a cohort study in which patients were identified in the Netherlands Cancer Registry in the Southeast of the Netherlands between 1990 and 2010. Of these patients, we collected all clinical characteristics and re-reviewed pathologic material to confirm NLPHL diagnosis. Seventy-three histologically confirmed cases of NLPHL were analyzed with a median follow-up of 65 months (range 4-257 months). Median age at diagnosis was 43 years (range 1-87); 84.9 % of the patients were male; B symptoms were present in 5.5 %; and stage I/II disease was most common (75.4 %). Patients were primarily treated with radiotherapy (50.7 %), chemotherapy (26 %), combined modality (radiotherapy and chemotherapy) (11 %), or surgical excision with careful watch-and-wait (12.3 %). Relapses occurred in seven patients (9.6 %) after a median of 26 months (21-74 months). Six patients (8.2 %) developed histologic transformation to large cell lymphoma. Five patients (6.8 %) died during follow-up due to progression of NLPHL (n = 1), histologic transformation (n = 2) and intercurrent deaths (n = 2). The estimated 10-year overall survival was 94.0 % and the 10-year progression-free survival 75.8 %. Our study confirms the distinct characteristics of NLPHL with a relatively good long-term prognosis. It may be possible to reduce treatment intensity in early stage NLPHL without affecting long-term outcome.

  10. Regulation of steroidogenesis in a primary pigmented nodular adrenocortical disease-associated adenoma leading to virilization and subclinical Cushing’s syndrome

    Science.gov (United States)

    Hofland, Johannes; de Herder, Wouter W; Derks, Lieke; Hofland, Leo J; van Koetsveld, Peter M; de Krijger, Ronald R; van Nederveen, Francien H; Horvath, Anelia; Stratakis, Constantine A; de Jong, Frank H; Feelders, Richard A

    2014-01-01

    Context Primary pigmented nodular adrenocortical disease (PPNAD) can lead to steroid hormone overproduction. Mutations in the cAMP protein kinase A regulatory subunit type 1A (PRKAR1A) are causative of PPNAD. Steroidogenesis in PPNAD can be modified through a local glucocorticoid feed-forward loop. Objective Investigation of regulation of steroidogenesis in a case of PPNAD with virilization. Materials and methods A 33-year-old woman presented with primary infertility due to hyperandrogenism. Elevated levels of testosterone and subclinical ACTH-independent Cushing’s syndrome led to the discovery of an adrenal tumor, which was diagnosed as PPNAD. In vivo evaluation of aberrantly expressed hormone receptors showed no steroid response to known stimuli. Genetic analysis revealed a PRKAR1A protein-truncating Q28X mutation. After adrenalectomy, steroid levels normalized. Tumor cells were cultured and steroidogenic responses to ACTH and dexamethasone were measured and compared with those in normal adrenal and adrenocortical carcinoma cells. Expression levels of 17β-hydroxysteroid dehydrogenase (17β-HSD) types 3 and 5 and steroid receptors were quantified in PPNAD, normal adrenal, and adrenal adenoma tissues. Results Isolated PPNAD cells, analogous to normal adrenal cells, showed both increased steroidogenic enzyme expression and steroid secretion in response to ACTH. Dexamethasone did not affect steroid production in the investigated types of adrenal cells. 17β-HSD type 5 was expressed at a higher level in the PPNAD-associated adenoma compared with control adrenal tissue. Conclusion PPNAD-associated adenomas can cause virilization and infertility by adrenal androgen overproduction. This may be due to steroidogenic control mechanisms that differ from those described for PPNAD without large adenomas. PMID:23065993

  11. Diffuse sclerosing variant of papillary thyroid carcinoma: case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seung Chan; Kim, Dong Wook [Masan Samsung Hospital, Sungkyunkwan University, School of Medicine, Masan (Korea, Republic of)

    2006-07-15

    Diffuse sclerosing papillary carcinoma (DSPC) is a variant of papillary thyroid carcinoma (PTC), but it shows more aggressive clinical course and a poorer prognosis than the other types of PTC. Most PTCs show a focal nodular pattern in the thyroid on the imaging modalities, but DSPC reveals a diffuse infiltrating configuration in the thyroid without any focal nodular lesion. To our knowledge, there are scant radiological reports of diffuse sclerosing variant of papillary thyroid carcinoma. In this report, we present the case of a patient with DSPC who showed the characteristic findings on sonography and computed tomography.

  12. Nodularization Comparison between Pour-Over Process and Cored Wire Injection Process%冲入法与喂线法球化处理工艺对比

    Institute of Scientific and Technical Information of China (English)

    姚成方; 李明; 张行河; 房夺

    2011-01-01

    Nodular iron camshafts of QT600-3 grade were produced with pour-over nodularizing process and cored wire injection process, their chemical composations, microstructures and properties were compared. The result showed that, for the nodular iron produced with cored wire injection process, the residual S content was relatively lower reaching the order of magnitude of 10~\\ fluctuation range of the residual Mg content was also narrow; nodularity and nodule count of castings was relatively higher, graphite size was small; mechanical properties of castings were good and stable.%采用冲入法和喂线法两种球化处理工艺生产QT600-3凸轮轴,对比其成分、组织和性能,结果表明:用喂线法生产的铸件,w(S残)量达到双零级、w(Mg残)量的波动亦小,且球化效果好(石墨球数量多、尺寸小、圆整度高、球化率高),力学性能良好稳定.

  13. Globalization of Mass Media and the Heterotopia and E -topia of Communication%论大众媒介的全球性及其传播的异托邦与伊托邦

    Institute of Scientific and Technical Information of China (English)

    邵培仁; 杨丽萍

    2011-01-01

    全球化使得地方文化的构成更加复杂,社会流动性的增加导致多样的文化景观的出现.多元文化之间的流动与交融,经由媒介,正在重建"巴别塔".从现实来看,资讯的发达使隔离状态瓦解,交流成为必然.在全球化进程中,媒介对于形成城市及城市文化的异托邦(heterotopia)与伊托邦(e-topia),具有极其重要的作用.尤其是诸如网络之类的全球性媒介,更是打造了一个伊托邦之城.

  14. A Nodular Foreign Body Reaction in a Dialysis Patient Receiving Long-term Treatment With Lanthanum Carbonate.

    Science.gov (United States)

    Valika, Aziz K; Jain, Dhanpat; Jaffe, Phillip E; Moeckel, Gilbert; Brewster, Ursula C

    2016-01-01

    A 63-year-old man with HIV (human immunodeficiency virus) infection and end-stage renal disease, treated with lanthanum carbonate phosphate binder for 4 years, presented with anemia and an upper gastrointestinal bleed. Upper endoscopy revealed a nodular hyperplastic epithelium, with an endoscopic ultrasound confirming hyperechoic material within the nodules. Light microscopy showed collections of histiocytes and multinucleated giant cells containing brown granular cytoplasmic material and extracellular crystalline material, a finding confirmed by electron microscopy. Similar pathologic findings associated with lanthanum exposure have been described recently. In our patient, lanthanum carbonate treatment was withdrawn and gastrointestinal bleeding has since ceased. The patient was exposed to a high amount of lanthanum over a long period, which may explain his adverse reaction. However, other contributing factors, such as competing medications or comorbid conditions, also may have increased his sensitivity to the drug.

  15. Fasciíte nodular em quirodáctilo que simula neoplasia maligna de partes moles

    Directory of Open Access Journals (Sweden)

    Soraya Silveira Monteiro

    2014-01-01

    Full Text Available Fasciíte nodular (FN é uma lesão proliferativa fibroblástica rara, caracterizada clinicamente como uma massa solitária de consistência endurecida, pouco dolorosa à palpação, de crescimento rápido e sem predileção por sexo. O objetivo deste trabalho é relatar o caso de uma paciente com FN no terceiro quirodáctilo da mão esquerda, descrever os achados da radiografia simples, tomografia computadorizada e ressonância magnética e correlacionar com a literatura. Visto que o diagnóstico de FN é um desafio, é necessário conciliar os achados clínicos, radiológicos e patológicos.

  16. A lógica e o sentido da formação: heterotopias, acontecimentos e sujeitos The logic and the meaning of the formation: different spaces, events and citizens

    Directory of Open Access Journals (Sweden)

    Carmen Lúcia Vidal Pérez

    2007-01-01

    Full Text Available O texto busca discutir a formação de professoras como um acontecimento. Acontecimentalizar essa formação é uma produção política que provoca um deslocamento radical dentro de um mesmo lugar, criando heterotopias que subvertem o sentido e transformam as ações de formação em práticas de uma educação-menor: pequenos acontecimentos cotidianos que silenciosamente deslizam para além das fronteiras do instituído, práticas de resistência que, ao inserir o produzir no produto, substituem os processos genéricos de alienação - que se reproduzem e se difundem no cotidiano da escola - por processos de emancipação da subjetividade, possibilitando, assim, a expressão de singularidades.The text searchs to argue the formation of teachers as an event. The formation as event is a politics production that inside provokes a radical displacement of one same place, creating heterotopias that transform the direction and transform the actions of formation into practical of a education-minor: small daily events that quiet slide for beyond the borders of the instituted one, practical of resistance that when inserting producing in the product, substitute the generic processes of alienation - that multiply and spread out in daily of the school - for processes of emancipation of the subjectivity - that they make possible the expression of the singularitys.

  17. Study of factors that influence the outcome of (131)I treatment in hyperthyroidism secondary to nodular goitre.

    Science.gov (United States)

    Tabuenca-Dopico, O; Boente-Varela, R; Lamas-Ferreiro, J L

    2017-06-12

    To assess the outcome after (131)I treatment in patients with multinodular (MNG) and nodular toxic goitre (NTG) according to the administered dose and other factors related to the patient, pathology, or previous treatments. A retrospective study was conducted on 108 patients (67 MNG and 41 NTG) treated in our department, with a follow-up period of at least 2 years. Development of hypothyroidism and treatment failure were evaluated along with their relationship with the administered dose and other factors such as age, sex, grade of hyperthyroidism, type of goitre, presence of autoimmunity, or previous antithyroid medication. More than one-third (36.9%) of MNG patients, and even higher proportion of NTG patients (51.2%) developed non-transient hypothyroidism, particularly in those receiving 740MBq (66.7%). No relationship was found with any other variable. The development of early hypothyroidism (before one year) was also not related to any variable. Treatment failure was not related to the dose, but in MNG there was a relationship with male gender, presence of autoimmunity, or previous antithyroid drugs use. The high rate of hypothyroidism obtained with high doses of (131)I in hyperthyroidism secondary to nodular goitre treatment suggests that lower doses might be sufficient to control the disease without an increase in treatment failures. Only patients with positive autoimmunity, in previous anti-thyroid medication, and perhaps male gender in MNG might be given higher doses, as the failure rate increases, but further studies are required. Copyright © 2017 Elsevier España, S.L.U. y SEMNIM. All rights reserved.

  18. Combination of microscopic model and VoF-multiphase approach for numerical simulation of nodular cast iron solidification

    Science.gov (United States)

    Subasic, E.; Huang, C.; Jakumeit, J.; Hediger, F.

    2015-06-01

    The ongoing increase in the size and capacity of state-of-the-art wind power plants is highlighting the need to reduce the weight of critical components, such as hubs, main shaft bearing housings, gear box housings and support bases. These components are manufactured as nodular iron castings (spheroid graphite iron, or SGI). A weight reduction of up to 20% is achievable by optimizing the geometry to minimize volume, thus enabling significant downsizing of wind power plants. One method for enhancing quality control in the production of thick-walled SGI castings, and thus reducing tolerances and, consequently, enabling castings of smaller volume is via a casting simulation of mould filling and solidification based on a combination of microscopic model and VoF-multiphase approach. Coupled fluid flow with heat transport and phase transformation kinetics during solidification is described by partial differential equations and solved using the finite volume method. The flow of multiple phases is described using a volume of fluid approach. Mass conservation equations are solved separately for both liquid and solid phases. At the micro-level, the diffusion-controlled growth model for grey iron eutectic grains by Wetterfall et al. is combined with a growth model for white iron eutectic grains. The micro-solidification model is coupled with macro-transport equations via source terms in the energy and continuity equations. As a first step the methodology was applied to a simple geometry to investigate the impact of mould-filling on the grey-to-white transition prediction in nodular cast iron.

  19. 口腔颌面部结节性筋膜炎临床病理分析%Clinical and Pathological Analysis of Nodular Fasciitis in Oral and Maxillofacial Region

    Institute of Scientific and Technical Information of China (English)

    李海如

    2015-01-01

    目的探讨结节性筋膜炎的临床及病理学特征及其鉴别诊断。方法对23例口腔颌面部结节性筋膜炎临床和病理资料进行复习,重新确诊。结果结节性筋膜炎表现为生长迅速,肿块小,质硬边界不清软组织肿块。光镜特点疏松的粘液样基质中有丰富的增生活>肥胖的梭形细胞,核分裂像多见,胆病理性核分裂罕见,低倍镜下呈疏密相间的“区带现象”,可呈席纹状,束状,半旋涡状或“S”形排列,基质内有小裂隙及微囊样形成呈网眼状结构,病灶边缘有新生毛细血管和炎细胞集中,红细胞外渗。结论结节性筋膜炎诊断应紧密结合其临床病史中生长快的特点,显微镜下注意观察5个组织学特征,因病理形态呈多态性,故易误诊为恶性软组织肉瘤。%Objective To explore the clinical and pathological features of nodular fasci tis and its dif erential diagnosis.Methods To review the 23 cases of oral and maxil ofacial nodular fasci tis:clinical and pathological data,re diagnosed.Results Nodular fasci tis showed rapid growth,mass of smal ,hard boundary is not clear soft tissue mass.A spindle cel rich hyperplastic obesity myxoid matrix light characteristics of osteoporosis,mitosis was common,bilious rational rare mitotic figures,at low magnification is spacing"zone phenomenon",can be in a storiform,fasciculate,semi spiral or"S"shaped ar angement,mucus like matrix loose feathery structure or tissue culture like growth,longer course,cicatricial col agen formation,stroma with smal cracks and microcystic form a mesh like structure,lesion edge newborn capil aries and inflammatory cel concentration,erythrocyte extravasation.Conclusion The diagnosis of nodular fasci tis should be closely combined with the characteristic of the clinical history in fast growth,pay at ention to characteristics of 5 tissue under the microscope observation,due to pathological morphology are polymorphic

  20. Pigmented villonodular synovitis of the spine: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Seong, Su Ok; Lee, Joo Hyuk; Yi, Jeong Geun [Cheongju St. Mary' s Hospital, Cheongju (Korea, Republic of)

    2000-10-01

    Pigmented villonodular synovitis (PVNS) is a synovial lesion of joints or tendon sheaths, characterized by villous and nodular overgrowth of the synovial membrane. It commonly occurs in synovial joints of the appendicular skeleton, particularly those of the knee and hip, but rarely affecting those of the spine. We report a case of PVNS of the lumbar spine mimicking epidural mass.

  1. Brain gray matter heterotopia: MRI diagnostic analysis of 18 cases%脑灰质异位症18例MRI诊断分析

    Institute of Scientific and Technical Information of China (English)

    张健; 孟凡荣; 朱光宇

    2006-01-01

    目的:提出脑灰质异位症的MRI诊断分型,提高对本病的认识.方法:分析18例脑灰质异位症的临床和MRI表现类型.结果:灰质异位症依据形态与位置,主张将其分为四型:室管膜下型、非室管膜下型、结节型、弥漫型.结论:灰质异位症的MRI表现具有特征性,将其分型能够提高对本病的认识,有利于作出正确的诊断.

  2. Nodular intra-abdominal panniculitis: an accompaniment of colorectal carcinoma and diverticular disease

    DEFF Research Database (Denmark)

    Bak, Martin

    1996-01-01

    was undertaken in order to describe the entire spectrum of the disease including primary as well as secondary cases. Eleven patients are reported, nine of which had an associated colorectal disease in direct continuity with areas of intra-abdominal panniculitis. It is concluded that intra-abdominal panniculitis...... should not be regarded as a specific nosological entity but merely a result of injury to the fat cells. Intra-abdominal panniculitis is seen more often as a secondary local phenomenon than as a primary condition, and in both cases it is associated with considerable differential diagnostic problems...

  3. Nodular intra-abdominal panniculitis: an accompaniment of colorectal carcinoma and diverticular disease

    DEFF Research Database (Denmark)

    Bak, Martin

    1996-01-01

    should not be regarded as a specific nosological entity but merely a result of injury to the fat cells. Intra-abdominal panniculitis is seen more often as a secondary local phenomenon than as a primary condition, and in both cases it is associated with considerable differential diagnostic problems...

  4. Pathological analysis of sclerosing anagiomatoid nodular transformation of spleen%脾硬化性血管瘤样结节性转化临床病理分析和文献复习

    Institute of Scientific and Technical Information of China (English)

    王宁; 孙爱静; 王伟; 陈丽荣

    2012-01-01

    Objective To review the clinicopathological features, diagnosis and differential diagnosis of sclerosing angiomatoid nodular transformation( SANT ) of spleen. Methods The clinical data, pathological findings, immunophenotypes and postoperative follow-up of 4 cases of SANT were investigated. Results There were no specific clinical manifestations in 4 cases of SANT,in which 3 cases were found in health check-up. Two were male and two female. Grossly, on the cut surface the masses were gray-white and un-encapsulated nodular measuring 3 ~ 5. 9 em in size. Microscopically, SANT was characterized by micronodular lesions consisting of vascular spaces lined by plump endothelial ceils with interspersed spindle cells. Immunohistochemieal results showed that the endothelial cells of vessels in angiomatoid nodules had various phenotypes; CD34 + /CD31 +/CD8- in endothelial cells of capillaries, CD34 - /CD31 + /CD8 + in lining cells of the sinusoids and CD34 - /CD31 + /CD8 - in endothelial cells of small veins. All patients were alive. Conclusions SANT is a benign lesion specially arising in spleen with a characteristic pathological appearance. The diagnosis relies on the pathological and imtnunohistoehemical findings. The disease can he cured by splenectomy with a favorable prognosis.%目的 探讨脾硬化性血管瘤样结节性转化(sclerosing anagiomatoid nodular transformation,SANT)的临床病理特征、诊断及鉴别诊断.方法 分析4例SANT的临床资料、组织病理学表现、免疫表型特征和术后随访情况.结果4例SANT患者男女各2例,临床表现为无包膜肿块,大体为3~5.9 cm边界清楚的灰白色结节.镜下见特征性的血管瘤样结节,免疫组织化学显示结节内内皮细胞异质性表达,即小叶状分布毛细血管,免疫表型为CD34、CD31阳性,CD8阴性,窦岸样细胞免疫表型为CD31、CD8阳性,CD34阴性,小静脉样血管免疫表型为CD31阳性,CD8、CD34阴性,结节内梭形细胞混合

  5. Characteristics and Outcomes of Patients With Nodular Lymphocyte-Predominant Hodgkin Lymphoma Versus Those With Classical Hodgkin Lymphoma: A Population-Based Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Gerber, Naamit K. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Atoria, Coral L.; Elkin, Elena B. [Department of Epidemiology and Biostatistics, Health Outcomes Research Group, New York, New York (United States); Yahalom, Joachim, E-mail: yahalomj@mskcc.org [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States)

    2015-05-01

    Purpose: Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is rare, comprising approximately 5% of all Hodgkin lymphoma (HL) cases. Patients with NLPHL tend to have better prognoses than those with classical HL (CHL). Our goal was to assess differences in survival between NLPHL and CHL patients, controlling for differences in patient and disease characteristics. Methods and Materials: Using data from the population-based Surveillance, Epidemiology and End Results (SEER) cancer registry program, we identified patients diagnosed with pathologically confirmed HL between 1988 and 2010. Results: We identified 1,162 patients with NLPHL and 29,083 patients with CHL. With a median follow-up of 7 years, 5- and 10-year overall survival (OS) rates were 91% and 83% for NLPHL, respectively, and 81% and 74% for CHL, respectively. After adjusting for all available characteristics, NLPHL (vs CHL) was associated with higher OS (hazard ratio [HR]: 0.62, P<.01) and disease-specific survival (DSS; HR: 0.48, P<.01). The male predominance of NLPHL, compared to CHL, as well as the more favorable prognostic features in NLPHL patients are most pronounced in NLPHL patients <20 years old. Among all NLPHL patients, younger patients were less likely to receive radiation, and radiation use has declined by 40% for all patients from 1988 to 2010. Receipt of radiation was associated with better OS (HR: 0.64, P=.03) and DSS (HR: 0.45, P=.01) in NLPHL patients after controlling for available baseline characteristics. Other factors associated with OS and DSS in NLPHL patients are younger age and early stage. Conclusions: Our results in a large population dataset demonstrated that NLPHL patients have improved prognosis compared to CHL patients, even after accounting for stage and baseline characteristics. Use of radiation is declining among NLPHL patients despite an association in this series between radiation and better DSS and OS. Unique treatment strategies for NLPHL are warranted in both

  6. Contrast-enhanced ultrasound features of histologically proven focal nodular hyperplasia: diagnostic performance compared with contrast-enhanced CT

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Wei; Chen, Li-Da; Liu, Guang-Jian; Xu, Zuo-Feng; Xie, Xiao-Yan; Wang, Yan; Zhou, Lu-Yao [The First Affiliated Hospital of Sun Yat-Sen University Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University, Department of Medical Ultrasonics, Guangzhou (China); Lu, Ming-De [The First Affiliated Hospital of Sun Yat-Sen University Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University, Department of Medical Ultrasonics, Guangzhou (China); The First Affiliated Hospital of Sun Yat-Sen University, Department of Hepatobiliary Surgery, Guangzhou (China); Shen, Shun-Li [The First Affiliated Hospital of Sun Yat-Sen University, Department of Hepatobiliary Surgery, Guangzhou (China)

    2013-09-15

    To investigate and compare contrast-enhanced ultrasound (CEUS) in the characterisation of histologically proven focal nodular hyperplasia (FNH) with contrast-enhanced computed tomography (CECT). CEUS was performed in 85 patients with 85 histologically proven FNHs. Enhancement, centrifugal filling, spoke-wheel arteries, feeding artery and central scarring were reviewed and correlated with lesion size or liver background. Independent factors for predicting FNH from other focal liver lesions (FLLs) were evaluated. Forty-seven FLLs with CECT were randomly selected for comparison of diagnostic performance with CEUS. Centrifugal filling was more common (P = 0.002) and the significant predictor (P = 0.003) in FNHs {<=}3 cm. Lesion size or liver background has no significant influence on the detection rate of the spoke-wheel arteries and feeding artery (P > 0.05). Central scarring was found in 42.6 % of FNHs {>=}3 cm (P = 0.000). The area under the ROC curve, sensitivity and specificity showed no significant differences between CEUS and CECT (P > 0.05), except that the sensitivity of CEUS was better for reader 1 (P = 0.041). CEUS is valuable in characterising centrifugal filling signs or spoke wheels in small FNHs and should be employed as the first-line imaging technique for diagnosis of FNH. (orig.)

  7. Statistical Study to Evaluate the Effect of Processing Variables on Shrinkage Incidence During Solidification of Nodular Cast Irons

    Science.gov (United States)

    Gutiérrez, J. M.; Natxiondo, A.; Nieves, J.; Zabala, A.; Sertucha, J.

    2017-04-01

    The study of shrinkage incidence variations in nodular cast irons is an important aspect of manufacturing processes. These variations change the feeding requirements on castings and the optimization of risers' size is consequently affected when avoiding the formation of shrinkage defects. The effect of a number of processing variables on the shrinkage size has been studied using a layout specifically designed for this purpose. The β parameter has been defined as the relative volume reduction from the pouring temperature up to the room temperature. It is observed that shrinkage size and β decrease as effective carbon content increases and when inoculant is added in the pouring stream. A similar effect is found when the parameters selected from cooling curves show high graphite nucleation during solidification of cast irons for a given inoculation level. Pearson statistical analysis has been used to analyze the correlations among all involved variables and a group of Bayesian networks have been subsequently built so as to get the best accurate model for predicting β as a function of the input processing variables. The developed models can be used in foundry plants to study the shrinkage incidence variations in the manufacturing process and to optimize the related costs.

  8. Nodular inflammatory foci are sites of T cell priming and control of murine cytomegalovirus infection in the neonatal lung.

    Directory of Open Access Journals (Sweden)

    Felix R Stahl

    Full Text Available Neonates, including mice and humans, are highly susceptible to cytomegalovirus (CMV infection. However, many aspects of neonatal CMV infections such as viral cell tropism, spatio-temporal distribution of the pathogen as well as genesis of antiviral immunity are unknown. With the use of reporter mutants of the murine cytomegalovirus (MCMV we identified the lung as a primary target of mucosal infection in neonatal mice. Comparative analysis of neonatal and adult mice revealed a delayed control of virus replication in the neonatal lung mucosa explaining the pronounced systemic infection and disease in neonates. This phenomenon was supplemented by a delayed expansion of CD8(+ T cell clones recognizing the viral protein M45 in neonates. We detected viral infection at the single-cell level and observed myeloid cells forming "nodular inflammatory foci" (NIF in the neonatal lung. Co-localization of infected cells within NIFs was associated with their disruption and clearance of the infection. By 2-photon microscopy, we characterized how neonatal antigen-presenting cells (APC interacted with T cells and induced mature adaptive immune responses within such NIFs. We thus define NIFs of the neonatal lung as niches for prolonged MCMV replication and T cell priming but also as sites of infection control.

  9. Performance of FDG PET/CT at initial diagnosis in a rare lymphoma: nodular lymphocyte-predominant Hodgkin lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Grellier, Jean Francois; Weinmann, Pierre [AP-HP- Hopital Europeen Georges Pompidou, Service de medecine nucleaire, Paris (France); Vercellino, Laetitia; Merlet, Pascal; Toubert, Marie-Elisabeth; Berenger, Nathalie [AP-HP- Hopital Saint-Louis, Service de medecine nucleaire, Paris (France); Leblanc, Thierry [Hopital Saint-Louis, Service d' immuno-hematologie, Paris (France); Thieblemont, Catherine [Universite Paris Diderot, Sorbonne Paris Cite - INSERM UMR-S1165, AP-HP- Hopital Saint-Louis, Service d' hemato-Oncologie, Paris (France); Briere, Josette [AP-HP- Hopital Saint-Louis, Service de pathologie, Paris (France); Brice, Pauline [AP-HP- Hopital Saint-Louis, Service d' hemato-Oncologie, Paris (France)

    2014-11-15

    Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare Hodgkin lymphoma distinguished from classical Hodgkin lymphoma (cHL) by the nature of the neoplastic cells which express B-cell markers. We wanted to determine the diagnostic performance of FDG PET/CT in initial assessment and its therapeutic impact on staging. We retrospectively studied a population of 35 patients with NLPHL (8 previously treated for NLHPL, 27 untreated). All patients underwent an initial staging by pretherapeutic FDG PET/CT. The impact on initial stage or relapse stage was assessed by an independent physician. In a per-patient analysis, the sensitivity of the pretherapeutic FDG PET/CT was 100 %. In a per-site analysis, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of pretherapeutic FDG PET/CT were 100 %, 99 %, 97 %, 100 % and 99 %, respectively. Pretherapeutic FDG PET/CT led to a change in the initial stage/relapse stage in 12 of the 35 patients (34 %). In contrast to previous results established without FDG PET/CT, 20 % of patient had osteomedullary lesions. Pretherapeutic FDG PET/CT has excellent performance for initial staging or relapse staging of NLPHL. (orig.)

  10. Nodular lymphocyte predominant Hodgkin lymphoma in Sweden between 2000 and 2014: an analysis of the Swedish Lymphoma Registry.

    Science.gov (United States)

    Molin, Daniel; Linderoth, Johan; Wahlin, Björn E

    2017-05-01

    Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is an indolent CD20(+) lymphoma. Its scarcity has made clinical trials difficult and there is no consensus on first-line treatment. We conducted a population-based study of all patients diagnosed with NLPHL in Sweden between 2000 and 2014 (N = 158; 41 women and 117 men), focusing on clinical features, therapy and overall survival. The median female and male age was 59 and 44 years, respectively (P = 0·002). In early-stage disease, there was little mortality and no survival differences between therapies. In patients with advanced-stage disease, mortality was relatively high in patients who did not receive first-line rituximab but absent in those who did (10-year survival, 55% vs. 100%; P = 0·033); there were no imbalances of prognostic factors between those two groups. In advanced stages, first-line rituximab use increased markedly between 2000-2004 and 2005-2014 (7% vs. 67%; P < 0·00005), as did 10-year survival, 53% vs. 72% (multivariate P = 0·027). Although all patients were diagnosed in the 2000s, this is the longest-followed (and largest) population-based cohort. We report a hitherto unreported 15-year median age difference between sexes, increasing rituximab use and improved survival. © 2017 John Wiley & Sons Ltd.

  11. Atypical variants of nodular lymphocyte-predominant Hodgkin lymphoma show low microvessel density and vessels of distention type.

    Science.gov (United States)

    Scheidt, Victoria; Hansmann, Martin-Leo; Schuhmacher, Bianca; Döring, Claudia; Hartmann, Sylvia

    2017-02-01

    Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) presents different histopathologic growth patterns, including atypical forms showing overlapping histopathologic and clinical features with T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL). Because growth patterns are associated with vessel distribution, the aim of the present study was to compare angiogenesis in different NLPHL patterns with THRLBCL as well as other lymphomas. Atypical variants of NLPHL and THRLBCL (n=10 per group) both showed a low microvessel density (MVD; 1.16-1.31/μm(2)) with a diffuse vessel distribution. In contrast, in typical NLPHL (n=10), follicular areas with low MVD were retained, whereas an increase in vessels in the interfollicular areas was observed (MVD 1.35/μm(2)). THRLBCL and typical NLPHL could additionally be distinguished by differences in their molecular angiogenesis signature. Furthermore, the number of intravascular T cells was significantly reduced in THRLBCL (0.0028 T cells/mm(2) vessel area) when compared with typical NLPHL (0.0059 T cells/mm(2) vessel area), potentially reflecting the different composition of the microenvironment in these 2 lymphoma entities. The results of our study reveal a similar vascular pattern and angiogenesis behavior in atypical NLPHL variants and THRLBCL in contrast to the retained follicular pattern in typical NLPHL. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. Helicobacter suis-Infected Nodular Gastritis and a Review of Diagnostic Sensitivity for Helicobacter heilmannii-Like Organisms

    Directory of Open Access Journals (Sweden)

    Shigeki Goji

    2015-05-01

    Full Text Available Helicobacter heilmannii-like organisms (HHLOs are associated with mucosa-associated lymphoid tissue lymphoma and peptic ulcer. However, the sensitivity of diagnostic tests for HHLOs, such as rapid urease test (RUT, urea breath test (UBT and blood antibody, is not high. Tightly coiled spiral microorganisms were found in the gastric mucosal biopsy specimen of a 48-year-old asymptomatic woman. Her findings were positive for RUT and UBT, but negative for blood antibody and stool antigen against H. pylori. A 7-day course of esomeprazole, amoxicillin and clarithromycin was administered, resulting in the successful eradication of the HHLOs. Analysis of the 16S rRNA and urease genes suggested a diagnosis of the HHLO H. suis. The sensitivity results of RUT, UBT, culture, blood antibody, immunohistochemistry and stool antigen were 40.0, 14.8, 0, 23.1, 40.0 and 0%, respectively. We report asymptomatic nodular gastritis due to an HHLO. Histological techniques, most likely with smears, are expected to be the most effective method for diagnosing infections by HHLOs, and genetic diagnosis by polymerase chain reaction can be very useful to identify the species of HHLOs.

  13. Molecular detection of avian pox virus from nodular skin and mucosal fibrinonecrotic lesions of Iranian backyard poultry.

    Science.gov (United States)

    Gholami-Ahangaran, Majid; Zia-Jahromi, Noosha; Namjoo, Abdolrasul

    2014-02-01

    In recent years, some outbreaks of skin lesions suspected to be avian pox were observed in the backyard poultry in different parts of western areas in Iran. Consequently, 328 backyard poultries with suspected signs of avian pox virus infection were sampled. All birds showed nodular lesions on unfeathered head skin and/or fibronecrotic lesions on mucus membrane of the oral cavity and upper respiratory tract. For histopathological analysis, the sections of tissue samples from cutaneous lesions of examined birds were stained with H&E method. For PCR, after DNA extraction a 578-bp fragment of avian pox virus from 4b core protein gene was amplified. Results showed 217 and 265 out of 328 (66.1 and 80.7%, respectively) samples were positive for avian pox virus on histopathological and PCR examination, respectively. In this study, the samples that had intracytoplasmic inclusion bodies on pathologic examination were PCR positive. This study revealed that PCR is a valuable tool for identification of an avian pox virus and that the frequency of pox infection in backyard poultry in western areas of Iran is high.

  14. Nodular inflammatory foci are sites of T cell priming and control of murine cytomegalovirus infection in the neonatal lung.

    Science.gov (United States)

    Stahl, Felix R; Heller, Katrin; Halle, Stephan; Keyser, Kirsten A; Busche, Andreas; Marquardt, Anja; Wagner, Karen; Boelter, Jasmin; Bischoff, Yvonne; Kremmer, Elisabeth; Arens, Ramon; Messerle, Martin; Förster, Reinhold

    2013-01-01

    Neonates, including mice and humans, are highly susceptible to cytomegalovirus (CMV) infection. However, many aspects of neonatal CMV infections such as viral cell tropism, spatio-temporal distribution of the pathogen as well as genesis of antiviral immunity are unknown. With the use of reporter mutants of the murine cytomegalovirus (MCMV) we identified the lung as a primary target of mucosal infection in neonatal mice. Comparative analysis of neonatal and adult mice revealed a delayed control of virus replication in the neonatal lung mucosa explaining the pronounced systemic infection and disease in neonates. This phenomenon was supplemented by a delayed expansion of CD8(+) T cell clones recognizing the viral protein M45 in neonates. We detected viral infection at the single-cell level and observed myeloid cells forming "nodular inflammatory foci" (NIF) in the neonatal lung. Co-localization of infected cells within NIFs was associated with their disruption and clearance of the infection. By 2-photon microscopy, we characterized how neonatal antigen-presenting cells (APC) interacted with T cells and induced mature adaptive immune responses within such NIFs. We thus define NIFs of the neonatal lung as niches for prolonged MCMV replication and T cell priming but also as sites of infection control.

  15. Focal Nodular Hyperplasia and Hepatocellular Adenoma around the World Viewed through the Scope of the Immunopathological Classification

    Directory of Open Access Journals (Sweden)

    Charles Balabaud

    2013-01-01

    Full Text Available Focal nodular hyperplasia (FNH and hepatocellular adenoma (HCA are benign hepatocellular tumors. The risk of bleeding and malignant transformation of HCA are strong arguments to differentiate HCA from FNH. Despite great progress that has been made in the differential radiological diagnosis of the 2 types of nodules, liver biopsy is sometimes necessary to separate the 2 entities. Identification of HCA subtypes using immunohistochemical techniques, namely, HNF1A-inactivated HCA (35–40%, inflammatory HCA (IHCA, and beta-catenin-mutated inflammatory HCA (b-IHCA (50–55%, beta-catenin-activated HCA (5–10%, and unclassified HCA (10% has greatly improved the diagnostic accuracy of benign hepatocellular nodules. If HCA malignant transformation occurs in all HCA subgroups, the risk is by far the highest in the β-catenin-mutated subgroups (b-HCA, b-IHCA. In the coming decade the management of HCA will be more dependent on the identification of HCA subtypes, particularly for smaller nodules (<5 cm in terms of imaging, follow-up, and resection.

  16. Modelling of nodular particle growth in a liquid-solid film during condensation experiments of copper-silver alloys

    Energy Technology Data Exchange (ETDEWEB)

    Leroux, S.; Ny, J. le; Gueneau, C.; Goldstein, S. [DCC/DPE/SPCP/LEPCA, Commissariat a l' Energie Atomique Saclay, Gif-sur-Yvette (France); Camel, D. [DTA/CEREM/DEM/SPCM, Commissariat a l' Energie Atomique, Centre d' Etudes Nucleaires de Grenoble, Grenoble (France)

    2001-07-01

    Silver-copper alloys are condensed in a liquid-solid domain of the phase diagram on a tilted molybdenum substrate regulated in temperature. After a droplets regime, a film which contains a monolayer of nodular solid crystals forms. The size distribution and density of the particles in the film are measured after different condensation times. Results show that in our experimental conditions a ripening process occurs which is evidenced by a decrease of the number of particles with time, and a broad particle size distribution. However, the decrease rate is smaller than expected without a condensation flux. A model is then developed to interpret and generalize these results. This model results from the modification of the Lifshitz-Slyosov model to take into account the supply from the vapour phase. It is shown that the higher the flux of material to solidify from the vapour phase is, the more the growth from the vapour phase overcomes the ripening process. Once the particle density reaches a characteristic value which is simply proportional to the incoming flux, no more particles are dissolved. The system then tends towards a monomodal distribution with a radius which grows in t{sup 1/3}. (orig.)

  17. Antithyroid drugs as a factor influencing the outcome of radioiodine therapy in Graves' disease and toxic nodular goitre?

    Energy Technology Data Exchange (ETDEWEB)

    Koerber, C.; Schneider, P.; Koerber-Hafner, N.; Haenscheid, H.; Reiners, C. [Wuerzburg Univ. (Germany). Abt. fuer Nuklearmedizin

    2001-09-01

    There is controversy over the factors that may influence the outcome of radioiodine therapy for benign thyroid diseases. Antithyroid medication has been claimed to negatively influence the effectiveness of radioiodine therapy in Graves' disease. In a longitudinal study, we assessed the influence of sex, age, antithyroid drugs, target radiation dose, target mass, applied activity, delivered dose, interval between last meal and application, and TSH, FT{sub 3} and FT{sub 4} levels on the outcome of radioiodine therapy. One hundred and forty-four patients (111 female, 33 male) suffering from Graves' disease (GD) and 563 patients (434 female, 129 male) with toxic nodular goitre (TNG) were entered in the study and followed up until 8 months after therapy. Treatment was defined as successful when the TSH level was found to be normal or elevated. Ninety-eight GD patients and 418 TNG patients were successfully treated. Forward stepwise multiple regression analysis models retained only the target mass in GD and the applied activity in TNG as significantly associated with the outcome of therapy. The predictive value of all variables involved was extremely low in both disease groups. Whereas concomitant antithyroid medication had no influence in GD, it adversely influenced radioiodine therapy of TNG. This effect may be attributed to a radioiodine ''steal phenomenon'' induced by TSH-stimulated normal thyroid tissue, which causes overestimation of the uptake in toxic nodules. (orig.)

  18. Fascitis nodular en la región frontal: a propósito de un caso excepcional y revisión de la literatura

    Directory of Open Access Journals (Sweden)

    Fátima Martínez Pérez

    2015-07-01

    Full Text Available La fascitis nodular es una entidad excepcional en el territorio maxilofacial, consiste en una proliferación benigna del tejido fibroblástico, de etiología desconocida y con características clínicas e histopatológicas similares a los sarcomas. La clínica habitual consiste en una masa de consistencia dura, indolora y de rápido crecimiento. Su diagnóstico se realiza mediante una biopsia y un estudio histopatológico. El tratamiento consiste en la exéresis quirúrgica completa de la lesión. El diagnóstico diferencial es esencial dado el alto potencial de confusión diagnóstica con lesiones sarcomatosas debido a la similitud de sus características clínicas e histopatológicas. Se presenta el segundo caso clínico en la literatura de fascitis nodular en la región frontal, un varón de 43 años de edad, sin sufrir traumatismo previo en dicha localización. Se procedió a la biopsia-exéresis de la lesión con el diagnóstico histológico de fascitis nodular. Sin evidencia de recurrencia del tumor y un resultado estético excelente.

  19. Influence of molding sand on the number of grains graphite and on the rate of thin ferrite in pieces in a nodular iron ferritic matrix

    Directory of Open Access Journals (Sweden)

    B. Khatemi

    2010-07-01

    Full Text Available The nodular cast irons are characterized by high mechanical properties compared to cast iron with lamellar graphite or vermiculargraphite. The ductile iron has already been the subject of many studies especially since the literature is rich on them, and sources of information are different. The fact is that the mechanical properties of nodular cast iron (FGS depend on the number of graphitegrains, their roundness, the solidification rate and nature of the matrix [3]. Many studies of nodular cast irons showed that the morespherical particles of graphite, the higher the mechanical properties are high. In gray cast irons, the graphite spheroids have anticrackingand give the ductile iron ductility. Note in this connection that the higher the number of graphite grains, the higher theductile iron has better mechanical properties. In cast iron, the nature of the matrix is depending on several parameters including thecooling rate of molten metal, the thickness, shape and dimensions of parts. The faster cooling is slow over rate of ferrite is important[3, 4]. In this paper, we tested three types of sand casting: sand –based sodium silicate, furan resin and green sand on samplesspherical graphite cast iron of different thickness. The objective in this article is to determine the number of grains of graphite andferrite for each type of sand casting under the same experimental conditions including the cooling rate and chemical composition ofthe liquid metal.

  20. 临床路径在结节性甲状腺肿手术患者中的应用%Application of clinical pathway in nodular goiter surgery patient

    Institute of Scientific and Technical Information of China (English)

    张元云

    2015-01-01

    目的:探讨临床路径在结节性甲状腺肿手术患者中的应用,评价其应用效果。方法将106例结节性甲状腺肿手术患者随机分为观察组和对照组各53例,观察组由主管医生和责任护士按照临床路径表的内容进行全程规范的检查、治疗、护理、观察及健康教育,对照组采用常规治疗、护理和健康教育。结果观察组患者对健康教育知识掌握优良率和对护理工作满意度均明显高于对照组( P<0.05)。结论临床路径的实施,有利于提高健康教育的效果及患者对护理工作的满意度。%Objective To observe the application of clinical pathway in nodular goiter surgery patient and e-valuate its effect.Methods 106 patients with nodular goiter surgery were randomly divided into observation group and control group, with 53 patients of each group.53 cases of observation group were standardized examined, treated, cared, observed and healthily educated by competent doctors and responsible nurses in accordance with the contents of the clini-cal pathway table.53 cases of control group were treated, cared and healthily educated normally.Results Excellent rate of patients grasping the health education and the nursing satisfaction in observation group were higher than those of control group ( P<0.05 ) .Conclusions The implement of clinical pathway is useful to improve the effect of health ed-ucation and the nursing satisfaction of patients.

  1. LOCALIZED PIGMENTED VILLONODULAR SYNOVITIS: CASE REPORT

    OpenAIRE

    2015-01-01

    This case concerned a female patient with a complaint of pain in the anterior region of her left knee during and after sports activities, followed by joint blockage three months ago. From imaging examinations, simple radiography of the knee was normal and magnetic resonance showed a solid expansive mass, possibly corresponding to soft-tissue chondroma or focal nodular synovitis. Arthroscopic resection of the lesion was performed, and the diagnosis of diffuse giant cell tumor resembling locali...

  2. Pigmented villous nodular synovitis mimicking metastatic melanoma on PET-CT

    Science.gov (United States)

    Selby, Luke; Kukar, Moshim; Wang, John; Beg, Mansoor; Sullivan, James

    2014-01-01

    INTRODUCTION Positron Emission Tomography – Computed Tomography (PET-CT) is routinely utilized in the management of melanoma, either as a part of staging workup or during surveillance. Since melanomas have a high metastatic potential, any FDG avid lesion is considered suspicious for recurrence. We report a case of a FDG avid lesion, diagnosed during melanoma surveillance, its management and review of literature. PRESENTATION OF CASE A 58 year-old-male underwent wide local excision for melanoma of the left cheek, and one year post-operatively a PET-CT that revealed a hypermetabolic focus in his right subscapularis muscle, which upon resection was diagnosed as Pigmented Villonodular Synovitis (PVNS). DISCUSSION PVNS is a rare benign giant cell tumor that requires no additional treatment in asymptomatic individuals. PET-CT is used for staging and surveillance of numerous malignancies, including melanoma. A hypermetabolic lesion on a PET-CT scan in the setting of malignancy is always suspicious for recurrence. CONCLUSION The surgeon is reminded of a uncommon benign FDG avid lesion. Typical location, nonspecific symptoms and characteristic imaging findings help cue in the diagnosis of PVNS and a tissue diagnosis will establish the diagnosis, thus avoiding unnecessarily aggressive surgical management. PMID:24705190

  3. Hepatopulmonary syndrome associated with nodular regenerative hyperplasia after liver transplantation in a child.

    Science.gov (United States)

    Alhosh, Rabea; Genyk, Yuri; Alexopoulos, Sophoclis; Thomas, Daniel; Zhou, Shengmei; Yanni, George; Kerkar, Nanda

    2014-08-01

    HPS is a significant complication of portal hypertension in children with chronic liver disease and is an established indication for LT. It is characterized clinically by the triad of pulmonary vascular dilatation causing hypoxemia in the setting of advanced liver disease. NRH, a cause of non-cirrhotic portal hypertension, is characterized by diffuse benign transformation of the hepatic parenchyma into small regenerative nodules with minimal or no fibrosis. Development of NRH and HPS in pediatric LT recipients has not been reported, although occasional cases have been reported in adult LT recipients. In this report, we discuss a case of a three-yr-old male who developed HPS, two yr after LT. Pulmonary and cardiac causes for hypoxemia were ruled out by appropriate investigations including a chest X ray, echocardiogram, cardiac catheterization, and a CT angiographic study. The diagnosis of HPS was confirmed via bubble echocardiogram that demonstrated intrapulmonary shunting. Open liver biopsy revealed marked NRH. The patient underwent liver retransplantation that resulted in complete reversal of his pulmonary symptoms and normal oxygen saturations within three months after LT.

  4. Directional solidification of flake and nodular cast iron during KC-135 low-g maneuvers

    Science.gov (United States)

    Curreri, P. A.; Stefanescu, D. M.; Hendrix, J. C.

    1984-01-01

    Alloys solidified in a low-gravity environment can, due to the elimination of sedimentation and convection, form unique and often desirable microstructures. One method of studying the effects of low-gravity (low-g) on alloy solidification was the use of the NASA KC-135 aircraft flying repetitive low-g maneuvers. Each maneuver gives from 20 to 30 seconds of low-g which is between about 0.1 and 0.001 gravity. A directional solidification furnace was used to study the behavior of off eutectic composition case irons in a low-g environment. The solidification interface of hypereutectic flake and spheroidal graphite case irons was slowly advanced through a rod sample, 5 mm in diameter. Controlled solidification was continued through a number of aircraft parabolas. The known solidification rate of the sample was then correlated with accelerometer data to determine the gravity level during solidification for any location of the sample. The thermal gradient and solidification rate were controlled independently. Samples run on the KC-135 aircraft exhibited bands of coarser graphite or of larger nodules usually corresponding to the regions solidified under low-g. Samples containing high phosphorous (used in order to determine the eutectic cell) exhibited larger eutectic cells in the low-g zone, followed by a band of coarser graphite.

  5. [Pancreatic choristoma in the gallbladder: report of two cases].

    Science.gov (United States)

    Beltrán, Marcelo A; Barría, Carlos; Naquira, Cecilia; Almonacid, Jorge; Cruces, Karina S

    2007-10-01

    Pancreatic choristoma is the occurrence of normal pancreatic tissue in an abnormal location without any anatomic continuity with the main body of the gland. Although heterotopia is uncommon in the gallbladder and biliary tract, anecdotic cases of gastric mucosa, liver, adrenal gland and pancreas among other tissues have been described. We report an eight year-old male and a 22 year-old female, electively operated for symptomatic cholelithiasis. On pathology, a nodule identified as a pancreatic endocrine and exocrine choristoma, was found in the gallbladder wall of both patients. We employed immunohistochemistry to characterize this choristoma. Tubular and epithelial structures were immunoreactive to cytokeratins 7, 8, 18, 19 and 20 and to CA19-9. Exocrine activity was documented by immunoreactivity to al-antitrypsin and al-chemotrypsin. Other immunohistochemical markers such as insulin and somatostatin were positive identifying endocrine activity.

  6. Cavitary Lesions and Nodular Infiltration Patterns in Multi-Drug Resistant TB and Non-Tuberculosis Mycobacterium: Comparison of Chest CT

    Directory of Open Access Journals (Sweden)

    Shahram Kahkouee

    2010-05-01

    Full Text Available Background/Objective: By increasing of HIV frequency, MDRTB has also increased. Clinical and laboratory findings of multi-drug resistant TB (MDRTB and non-tuberculosis mycobacterium (NTM are very similar. Maybe imaging findings help early differentiation before culture result. This study has compared cavitary lesions and nodular infiltration patterns in the chest CT of MDRTB and NTM."nPatients and Methods: A retrospective study was performed on 66 hospitalized patients (43 MDRTB and 23 NTM in Masih Daneshvari Hospital (from 2006-2009. Lung CT scans were evaluated by a radiologist and two radiology residents without any information about the culture result. Nodular infiltrations were classified into 6 patterns (tree in bud, scattered nodule, lobar nodular infiltration, cavitary nodule, macronodule, miliary pattern and cavitary lesions to thick and thin, single and multiple with lobar distribution and satellite nodule adjacent to cavity. Chi-square statistics analysis was performed."nResult: Respectively in NTM and MDRTB: Mean age (51.5%-44.8%, sex (34.8% M and 65.2 F, 58.1% M and 41.9% F, treatment history (56.5%,83.7%, scattered nodular infiltration (47.8%, 60.5%, lobar nodular infiltration (13%, 9.3%, TIB (47.8%, 46.5%, miliary pattern (0%, 0%, cavitary nodule (21.7%, 27.9%, macro nodule (nodule≥10mm (43.5%, 25.6%, cavity (69.6%, 76.7%, thin wall cavity (65.2%, 46.5%, thick wall cavity (26.1%, 58.1%, satellite nodule adjacent to cavity (39.1%, 9.3%, single cavity (13%, 14%, lobar distribution of single cavity: RUL (8.7%, 4.7%, RML (0%, 0%, RLL (0%, 0%, LUL (4.3%, 4.7%, lingual (0%, 0%, LLL (0%, 4.7%, multiple cavity (56.5%, 60.5%, lobar distribution of multiple cavity: RUL (26.1%, 51.2%, RML (21.7%, 9.3%, RLL (26.1%, 23.3%, LUL (47.8%, 44.2%, lingual (26.1%, 18.6%, LLL (30.4%, 16.3%."nConclusion: Treatment history (p=0.016, satellite nodule adjacent to cavity (p=0.004, thick wall cavity (p=0.013 and multiple cavity in RUL (p=0.05 are more

  7. Cério (Ce em ferricretes nodulares desenvolvidos em solos da formação adamantina Cerium (Ce in some nodular ferricretes developed in soils of the adamantina formation

    Directory of Open Access Journals (Sweden)

    Maurício Rizzato Coelho

    2000-06-01

    Full Text Available O estudo de concentrações anômalas de elementos traço em ferricretes, como cério (Ce e outros elementos das terras raras, tem apoiado discussões a respeito da gênese dessas feições em diferentes ambientes do planeta. No município de Pindorama (SP, no sopé de uma vertente com domínio de Argissolos Vermelho-Amarelos abrúpticos derivados do arenito cretácico da Formação Adamantina, Grupo Bauru (Ka, ocorrem horizontes ferricretes, cujas características e gênese são escassamente conhecidas, embora sejam de ocorrência comum na região norte do Estado de São Paulo. Procurou-se verificar a presença de concentrações de elementos terras raras nesses solos e assim poder fornecer subsídios para o conhecimento da gênese desses ferricretes, estudando-se um Argissolo Vermelho-Amarelo Eutrófico abrúptico plíntico dessa vertente. Após descrição morfológica do perfil, determinou-se a granulometria, bem como as concentrações de Fe e Mn totais (fluorescência de raios X, extraídos por ataque sulfúrico, ditionito-citrato e por oxalato dos horizontes e dos nódulos encontrados. Em glébulas selecionadas, realizou-se estudos submicroscópicos e microanálises pontuais. Acumulações localizadas de Ce na forma de cerianita (CeO2 foram encontradas apenas nos nódulos petroplínticos que apresentam revestimentos de óxidos de Mn, situados na base do horizonte petroplíntico, e cuja gênese está associada ao rebaixamento definitivo do lençol freático. Cobalto (Co também se concentra no interior dos nódulos ferro-manganíferos devido à ação co-precipitadora dos óxidos de manganês aí depositados.The observation of rare earth element (REE accumulations, especially Ce, has led to an open discussion about the genesis of lateritic weathering systems. In the landscape of the northern State of São Paulo (Brazil, lateritic covers predominantly nodular exist in different topographic levels and, although not documented, constitute a

  8. Dermatitis artefacta: Three case reports

    Directory of Open Access Journals (Sweden)

    Walia N

    2006-01-01

    Full Text Available Three cases of dermatitis artefacta are reported for their varied presentation, diagnostic indicators and complex management. A 21-year-old soldier had multiple painful erosions on dorsum of both forearms of three weeks duration normal with inbetween skin. By occlusive bandaging dressing lesions healed without recurrence. A 28-year-old mechanic had recurrent blisters with non healing wounds on the right knee without surrounding inflammation. Histopathology was nonspecific. A young soldier had multiple asymphomatic nodular lesion in linear distribution on right forearm of two years induration. Biopsy showed features of scar. Psychiatric evaluation and follow-up was essential in all cases.

  9. Focal nodular hyperplasia of the liver in children after hematopoietic stem cell transplantation.

    Science.gov (United States)

    Masetti, Riccardo; Zama, Daniele; Gasperini, Pietro; Morello, William; Prete, Arcangelo; Colecchia, Antonio; Festi, Davide; Pession, Andrea

    2013-08-01

    FNH is a non-malignant neoplasia of the liver rarely described in children. A significant percentage of the pediatric cases have been reported in patients with a history of malignant disease treated with chemo-radiation therapy and in children who were given HSCT. Little is known about the pathogenesis of FNH in transplanted children, but many risk factors linked to the HSCT procedure have been hypothesized. The detection of hepatic nodules, particularly in children who underwent HSCT for a previous malignancy, always raises a diagnostic dilemma. To help the physicians in the diagnostic management of this rare entity, we have retrospectively evaluated a series of transplanted children diagnosed with FNH in our Center over the last 15 yr. In this period, we found 10 new diagnoses of FNH. The diagnostic work-up included CEUS, abdominal CT, and MRI. A liver biopsy was performed in two patients. The median FUP time after diagnosing FNH was 3.8 yr, with an abdominal US and no malignant transformation were observed. Possible risk factors and indications for the management of FNH in transplanted children are reported and discussed in a comprehensive review of the literature.

  10. 柴油机球墨铸铁飞轮应力与断裂损伤失效分析%Stress and fracture damage analysis of nodular iron flywheel for diesel engine

    Institute of Scientific and Technical Information of China (English)

    周霞; 李红彩; 窦慧莉; 吴承伟

    2011-01-01

    Nodular iron flywheel is one of the parts which have relatively simple structure but play an important role in diesel engine. In the case of disc-shaped nodular iron flywheels, the structural damage behavior is strongly influenced by complex three-dimensional stress states in the flywheel structure. The complex three-dimensional stress states in combination with the ordinary radial, axial and tangential stresses are caused by high speed rotating of the flywheel. In addition, the structural damage behavior of the flywheel is also related to its surface fatigue wear. In order to analyze the relationship between the complex three-dimensional stress and failure of the high-speed rotating flywheel, the stress distributions of radial stress, axial stress and tangential stress were given by finite element method, the limit speed of the flywheel and its fracture damage forms were predicted; In the mean time, experimental analysis was carried out for the fracture and damage of the flywheel. The experimental results are in agreement with the finite element analysis results. Such method of combining finite element with experiment analysis is of important guiding significance for the failure analysis and structural optimization design of the flywheel.%球墨铸铁飞轮是柴油机中结构形状相对简单但起重要作用的零件之一.对于圆盘状球墨铸铁飞轮,其结构破坏行为往往与飞轮在高速旋转时所引起的包含径向,轴向及环向等复杂的三维应力状态有关.此外,还与其表面摩擦损伤有关.为了分析飞轮高速旋转时的复杂应力状态与其断裂损伤失效之间的关系,用有限元方法分析了球墨铸铁飞轮在高速旋转时径向应力、轴向应力及环向应力的分布情况,预测飞轮的极限转速及断裂损伤形式,同时用实验的方法进行验证分析,实验所得结果与有限元分析结果具有很好的一致性.该方法对飞轮失效分析及飞轮结构优化设

  11. Risk of thyroid nodular disease and thyroid cancer in patients with acromegaly--meta-analysis and systematic review.

    Directory of Open Access Journals (Sweden)

    Kosma Wolinski

    Full Text Available INTRODUCTION: Acromegaly is a quite rare chronic disease caused by the increased secretion of growth hormone (GH and subsequently insulin - like growth factor 1. Although cardiovascular diseases remains the most common cause of mortality among acromegalic patients, increased prevalence of malignant and benign neoplasms remains a matter of debate. The aim of this study is to evaluate the risk of thyroid nodular disease (TND and thyroid cancer in patients with acromegaly. MATERIALS AND METHODS: PubMed, Cochrane Library, Scopus, Cinahl, Academic Search Complete, Web of Knowledge, PubMed Central, PubMed Central Canada and Clinical Key databases were searched to identify studies containing. Random-effects model was used to calculate pooled odds ratios and risk ratios of TND in acromegaly. Studies which not included control groups were systematically reviewed. RESULTS: TND was more frequent in acromegaly than in control groups (OR = 6.9, RR = 2.1. The pooled prevalence of TND was 59.2%. Also thyroid cancer (TC proved to be more common in acromegalic patients (OR = 7.5, RR = 7.2, prevalence was 4.3%. The pooled rate of malignancy (calculated per patient was equal to 8.7%. CONCLUSIONS: This study confirms that both TND and TC occur significantly more often in acromegalic patients than in general population. These results indicate that periodic thyroid ultrasound examination and careful evaluation of eventual lesions should be an important part of follow-up of patients with acromegaly.

  12. Preoperative TSH level and risk of thyroid cancer in patients with nodular thyroid disease: nodule size contribution.

    Science.gov (United States)

    Zafón, Carles; Obiols, Gabriel; Mesa, Jordi

    2015-01-01

    Many reports have supported the relationship between high preoperative TSH levels and risk of thyroid cancer in nodular thyroid disease (NTD). We investigated whether TSH levels are related to the risk of differentiated thyroid carcinoma (DTC) in patients who have undergone total thyroidectomy for NTD. The relationship between TSH and size of malignant nodule was investigated. Finally, we assessed whether TSH levels are related to DTC and presence of additional benign nodules. A retrospective study of 980 patients was conducted. Variables included age at diagnosis, TSH level, nodule size, gender, final histology (benign versus DTC), and type of malignancy. Malignancy was present in 261 (26.6%) patients. These patients had higher median TSH levels as compared to those with no malignancy (1.61 mU/L (0.9-2.5) versus 0.9 mU/L (0.3-1.6); p-value<0.001). TSH was higher in patients with DTC in whom the largest nodule was malignant than in patients in whom the largest nodule was benign (1.80 mU/L (1.1-2.6) versus 1.38 mU/L (0.7-2.1) respectively; p-value=0.025). A significant correlation was seen between malignant nodule size and TSH level, but not between TSH levels and size of the largest benign nodule. Our study supported an association between preoperative TSH levels and risk of DTC in patients with NTD. There was also a direct relationship between malignant nodule size and TSH levels. By contrast, no relationship was found between the size of benign nodules and TSH levels. Copyright © 2014 SEEN. Published by Elsevier Espana. All rights reserved.

  13. Dose establishing a safety margin reduce local recurrence in subsegmental transarterial chemoembolization for small nodular hepatocellular carcinomas?

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Hyo Jin; Kim, Young Il; Kim, Hyo Cheol; Jae, Hwan Jun; Hur, Sae Beam; Chung, Jin Wook [Dept. of Radiology, Seoul National University Hospital, Seoul(Korea, Republic of)

    2015-10-15

    To test the hypothesis that a safety margin may affect local tumor recurrence (LTR) in subsegmental chemoembolization. In 101 patients with 128 hepatocellular carcinoma (HCC) nodules (1-3 cm in size and ≤ 3 in number), cone-beam CT-assisted subsegmental lipiodol chemoembolization was performed. Immediately thereafter, a non-contrast thin-section CT image was obtained to evaluate the presence or absence of intra-tumoral lipiodol uptake defect and safety margin. The effect of lipiodol uptake defect and safety margin on LTR was evaluated. Univariate and multivariate analyses were performed to indentify determinant factors of LTR. Of the 128 HCC nodules in 101 patients, 49 (38.3%) nodules in 40 patients showed LTR during follow-up period (median, 34.1 months). Cumulative 1- and 2-year LTR rates of nodules with lipiodol uptake defect (n = 27) and those without defect (n = 101) were 58.1% vs. 10.1% and 72.1% vs. 19.5%, respectively (p < 0.001). Among the 101 nodules without a defect, the 1- and 2-year cumulative LTR rates for nodules with complete safety margin (n = 52) and those with incomplete safety margin (n = 49) were 9.8% vs. 12.8% and 18.9% vs. 19.0% (p = 0.912). In multivariate analyses, ascites (p = 0.035), indistinct tumor margin on cone-beam CT (p = 0.039), heterogeneous lipiodol uptake (p = 0.023), and intra-tumoral lipiodol uptake defect (p < 0.001) were determinant factors of higher LTR. In lipiodol chemoembolization, the safety margin in completely lipiodolized nodule without defect will not affect LTR in small nodular HCCs.

  14. 高Ni奥氏体球墨铸铁的生产%Production of Hi-Ni Austenite Nodular Irons

    Institute of Scientific and Technical Information of China (English)

    赵新武; 张居卿

    2011-01-01

    The chemical composition, mierostructure, mechanical properties, melting proess, riser design and heat treating process etc. Were summarized. The fullness theory was re-validated and it was showed that when fullness and CE was relatively higher, the graphitization would be more complete, the liquidus temperature would be more lower that would create conditions to adopt lower melting and pouring temperature, the high temperature oxidizing tendency of the iron melt would be decreased and its flowability would be more better. It was proved through process test that in order to increase mechanical properties of the high Ni austenite nodular iron, it's not suitable to adopt high temperature annealing plus slowly cooling process, but to adopt high temperature annealing plus fast cooling process.%介绍了高Ni奥氏体球墨铸铁的化学成分、金相组织和力学性能控制范围和方法,阐述了其熔炼、浇注及热处理工艺的要点.用大量试验数据说明,当充满度和CE较高时,石墨化更充分,液相线温度更低,铁液高温氧化性降低,流动性更好.工艺试验证明,高Ni奥氏体球墨铸铁不能采用高温退火缓冷工艺,可以通过高温退火快冷的方法提高其力学性能.

  15. Expression of mucosal addressin cell adhesion molecule 1 on vascular endothelium of gastric mucosa in patients with nodular gastritis

    Institute of Scientific and Technical Information of China (English)

    Hiroshi Ohara; Takehiko Koji; Hiroshi Nagura; Shigeru Kohno; Hajime Isomoto; Chun-Yang Wen; Chieko Ejima; Masahiro Murata; Masanobu Miyazaki; Fuminao Takeshima; Yohei Mizuta; Ikuo Murata

    2003-01-01

    AIM: The interaction of mucosal addressin cell adhesion molecule 1 (MAdCAM-1) with integrin α4β7 mediates lymphocyte recruitment into mucosa-associated lymphoid tissue (MALT). Nodular gastritis is characterized by a unique military pattern on endoscopy representing increased numbers of lymphoid follicles with germinal center, strongly associated with H pylori infection. The purpose of this study was to address the implication of the MAdCAM-1/integrin β7 pathway in NG.METHODS: We studied 17 patients with NG and H pylori infection and 19 H pylori-positive and 14 H pylori-negative controls. A biopsy sample was taken from the antrum and snap-frozen for immunohistochemical analysis of MAdCAM1 and integrin β7. In simultaneous viewing of serial sections,the percentage of MAdCAM-1-positive to von Willebrand factor-positive vessels was calculated. We also performed immunostaining with anti-CD20, CD4, CD8 and CD68 antibodies to determine the lymphocyte subsets coexpressing integrin β7.RESULTS: Vascular endothelial MAdCAM-1 expression was more enhanced in gastric mucosa with than without H pylori infection. Of note, the percentages of MAdCAM-1-positive vessels were significantly higher in the lamina propria of NG patients than in H pylori-positive controls. Strong expression of MAdCAM-1 was identified adjacent to lymphoid follicles and dense lymphoid aggregates. Integrin β7-expressing mononuclear cells, mainly composed of CD20 and CD4 lymphocytes, were associated with vessels lined with MAdCAM-1-expressing endothelium.CONCLUSION: Our results suggest that the MAdCAM-1/integrin α4β7 homing system may participate in gastric inflammation in response to H pylori-infection and contributes to MALT formation, typically leading to the development of NG.

  16. Bacillary angiomatosis in HIV-positive patient from Northeastern Brazil: a case report

    Directory of Open Access Journals (Sweden)

    Renata Félix da Justa

    2011-10-01

    Full Text Available It is a report of disseminated bacillary angiomatosis (BA in a 23-year-old female patient, who is HIV-positive and with fever, weight loss, hepatomegaly, ascites, and papular-nodular skin lesions. The clinical and diagnostic aspects involved in the case were discussed. Bacillary angiomatosis must always be considered in the diagnosis of febrile cutaneous manifestations in AIDS.

  17. Hypertrophic nerve roots in a case of Roussy-Levy syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Haubrich, C.; Senderek, J.; Noth, J.; Toepper, R. [Neurologische Klinik, Aachen University, Pauwelsstrasse 30, 52074 Aachen (Germany); Krings, T. [Klinik fuer Neuroradiologische Diagnostik, Aachen University, Pauwelsstrasse 30, 52074 Aachen (Germany); Zuechner, S.; Schroeder, J.M. [Institut fuer Neuropathologie, Aachen University, Pauwelsstrasse 30, 52074 Aachen (Germany)

    2002-11-01

    Hypertrophic radiculopathy is a rare feature of neuropathies. Single cases of enlarged nerve roots have been described in hereditary motor sensory neuropathies (HMSN) and chronic inflammatory demyelinating diseases (CIDP). This is the first description of hypertrophied nerve roots in a patient with Roussy-Levy syndrome. MRI did not show contrast enhancement of the enlarged nerve roots or nodular lesions. (orig.)

  18. Concurrent Liver Hodgkin Lymphoma and Nodular Regenerative Hyperplasia on an Explanted Liver with Clinical Diagnosis of Alcoholic Cirrhosis at University Hospital Fundación Santa Fe de Bogotá

    Directory of Open Access Journals (Sweden)

    R. López

    2014-01-01

    Full Text Available Liver involvement by Hodgkin lymphoma (HL is well documented. However, secondary liver failure to this neoplastic process is rare and usually presents late in the course of the disease. We present a case of a HL associated with nodular regenerative hyperplasia (NRH diagnosed on an explanted liver from a 53-year-old patient with clinical diagnosis of alcoholic cirrhosis. Hematoxylin and eosin stain (H&E showed abnormal liver architecture with hepatocytes nodules highlighted by reticulin stain with absent fibrosis on the trichrome stain. The portal spaces had diffuse infiltration by Reed-Sternberg cells positive for CD15, CD30, and latent membrane protein (LMP on immunohistochemical studies. The patient also had a concurrent hilar lymph node biopsy that also showed HL involvement. Liver failure as the initial presentation of Hodgkin’ lymphoma is rare. We believe that more research about the utility of performing liver biopsies in patients candidates for transplantation with noncirrhotic hepatic failure is needed in order to establish the etiology and the optimal treatment.

  19. Concurrent liver hodgkin lymphoma and nodular regenerative hyperplasia on an explanted liver with clinical diagnosis of alcoholic cirrhosis at university hospital fundación santa fe de bogotá.

    Science.gov (United States)

    López, R; Barrera, L; Vera, A; Andrade, R

    2014-01-01

    Liver involvement by Hodgkin lymphoma (HL) is well documented. However, secondary liver failure to this neoplastic process is rare and usually presents late in the course of the disease. We present a case of a HL associated with nodular regenerative hyperplasia (NRH) diagnosed on an explanted liver from a 53-year-old patient with clinical diagnosis of alcoholic cirrhosis. Hematoxylin and eosin stain (H&E) showed abnormal liver architecture with hepatocytes nodules highlighted by reticulin stain with absent fibrosis on the trichrome stain. The portal spaces had diffuse infiltration by Reed-Sternberg cells positive for CD15, CD30, and latent membrane protein (LMP) on immunohistochemical studies. The patient also had a concurrent hilar lymph node biopsy that also showed HL involvement. Liver failure as the initial presentation of Hodgkin' lymphoma is rare. We believe that more research about the utility of performing liver biopsies in patients candidates for transplantation with noncirrhotic hepatic failure is needed in order to establish the etiology and the optimal treatment.

  20. Comparison of PTCH1, COX-2, p53, and Ki-67 protein expression in basal cell carcinomas of nodular and superficial subtypes arising on the head and trunk.

    Science.gov (United States)

    Khalesi, Mohammad; Waterhouse, Mary; Whiteman, David C; Johns, Richard; Rosendahl, Cliff; Hackett, Timothy; Pollak, Thomas; Kimlin, Michael G; Hacker, Elke; Neale, Rachel E

    2016-10-01

    There is some evidence that basal cell carcinomas (BCCs) arising on different anatomic sites and developing to different histological subtypes differ in their pathophysiology. The expression of a number of proteins, including PTCH1, COX-2, p53, and Ki-67, is frequently altered in BCC development. This study sought to determine whether protein expression differs between BCCs at different anatomic sites and of different histological subtypes. Expression of PTCH1, COX-2, p53, and Ki-67 proteins was compared between: (i) BCCs arising on the head (n = 55) and trunk (n = 53), and (ii) nodular (n = 52) and superficial (n = 43) BCCs. The intensity of immunohistochemistry (IHC) staining (low, moderate, strong, very strong) for PTCH1 and COX-2 proteins was measured and the proportions of p53- and Ki-67-positive cells quantified. The proportion of cells expressing Ki-67 was higher in tumor tissue than in non-malignant epidermis, whereas the opposite was found for PTCH1. The IHC staining intensity for PTCH1 was substantially greater in truncal BCCs than in BCCs on the head (odds ratio [OR] 3.82, 95% confidence interval [CI] 1.63-8.96). The intensity of staining for PTCH1 was greater for superficial than for nodular BCCs (OR 3.70, 95% CI 1.53-8.97), and superficial BCCs showed a higher proportion of Ki-67-positive cells (OR 5.57, 95% CI 1.66-18.67). These differences suggest that the pathophysiology of BCC differs between lesions on the head and trunk and between nodular and superficial subtypes, perhaps indicating differences in their etiology. © 2016 The International Society of Dermatology.