Ebola outbreak response: the role of information resources and the National Library of Medicine.

Science.gov (United States)

Love, Cynthia B; Arnesen, Stacey J; Phillips, Steven J

2015-02-01

The US National Library of Medicine (NLM) offers Internet-based, no-cost resources useful for responding to the 2014 West Africa Ebola outbreak. Resources for health professionals, planners, responders, and researchers include PubMed, Disaster Lit, the Web page "Ebola Outbreak 2014: Information Resources," and the Virus Variation database of sequences for Ebolavirus. In cooperation with participating publishers, NLM offers free access to full-text articles from over 650 biomedical journals and 4000 online reference books through the Emergency Access Initiative. At the start of a prolonged disaster event or disease outbreak, the documents and information of most immediate use may not be in the peer-reviewed biomedical journal literature. To maintain current awareness may require using any of the following: news outlets; social media; preliminary online data, maps, and situation reports; and documents published by nongovernmental organizations, international associations, and government agencies. Similar to the pattern of interest shown in the news and social media, use of NLM Ebola-related resources is also increasing since the start of the outbreak was first reported in March 2014.

PubMed Central: An Essential Resource for Information Professionals and Researchers. A Review of: Cornell, A., Bushman, B., & Womack, K. (2011. Analysis of journals that did not meet selection criteria for inclusion in the National Library of Medicine collection but have manuscripts in PubMed Central. Journal of the Medical Library Association, 99, 168-170.

Directory of Open Access Journals (Sweden)

Joanne L. Jordan

2013-06-01

be met and 11 of these journals have subsequently been added to the NLM collection. This is in relation to 482 new print and electronic journals in total that were added to the NLM collection in 2009.However, only 369 of the 571 journals (65% had one or more articles included in PMC; of these, 238 had one article and 33 had more than four articles in the archive. The reason that some journals had no articles in PMC at the time of this review was due to the time it takes to process new articles and embargos set by the publishers that restrict immediate listing on open access databases such as PMC. A number of these journals may also be new and may not have had a sufficient number of articles or enough information available to be able to include them in the NLM collection. To add context, the authors state that PMC contained over 115,000 NIH-funded articles by the end of November 2010.The subject areas these non-selected journals were classified under included Engineering (15%; Medicine (14%; Mathematics (10%; Chemistry (10%; and Computer Science (9%. Library Science was assigned to 2% of the journals. The Medicine journals were more likely than those in the other subject areas to be new journals without sufficient articles to be included in the NLM collection.Conclusion – When the journal title is out of the scope of the NLM collection, an individual article in that journal can still be included in PMC. This provides a solution to the problem of how to collect biomedical research that is not published in biomedical journals. This may be more important in the future as the field becomes more interdisciplinary. This also provides a useful resource for libraries and researchers searching for full-text biomedical articles.The authors conclude that analyzing the articles from the journals not selected for inclusion in the NLM collection will provide helpful information about the types of biomedical research being published in non-biomedical journals. This will highlight

Tay-Sachs - resources

Science.gov (United States)

The following organizations provide information on Tay-Sachs disease : US National Library of Medicine -- ghr.nlm.nih.gov/condition/tay-sachs-disease March of Dimes -- www.marchofdimes.org/complications/tay-sachs- ...

Adaptive non-local means on local principle neighborhood for noise/artifacts reduction in low-dose CT images.

Science.gov (United States)

Zhang, Yuanke; Lu, Hongbing; Rong, Junyan; Meng, Jing; Shang, Junliang; Ren, Pinghong; Zhang, Junying

2017-09-01

Low-dose CT (LDCT) technique can reduce the x-ray radiation exposure to patients at the cost of degraded images with severe noise and artifacts. Non-local means (NLM) filtering has shown its potential in improving LDCT image quality. However, currently most NLM-based approaches employ a weighted average operation directly on all neighbor pixels with a fixed filtering parameter throughout the NLM filtering process, ignoring the non-stationary noise nature of LDCT images. In this paper, an adaptive NLM filtering scheme on local principle neighborhoods (PC-NLM) is proposed for structure-preserving noise/artifacts reduction in LDCT images. Instead of using neighboring patches directly, in the PC-NLM scheme, the principle component analysis (PCA) is first applied on local neighboring patches of the target patch to decompose the local patches into uncorrelated principle components (PCs), then a NLM filtering is used to regularize each PC of the target patch and finally the regularized components is transformed to get the target patch in image domain. Especially, in the NLM scheme, the filtering parameter is estimated adaptively from local noise level of the neighborhood as well as the signal-to-noise ratio (SNR) of the corresponding PC, which guarantees a "weaker" NLM filtering on PCs with higher SNR and a "stronger" filtering on PCs with lower SNR. The PC-NLM procedure is iteratively performed several times for better removal of the noise and artifacts, and an adaptive iteration strategy is developed to reduce the computational load by determining whether a patch should be processed or not in next round of the PC-NLM filtering. The effectiveness of the presented PC-NLM algorithm is validated by experimental phantom studies and clinical studies. The results show that it can achieve promising gain over some state-of-the-art methods in terms of artifact suppression and structure preservation. With the use of PCA on local neighborhoods to extract principal structural

Preclinical evaluations of norcantharidin-loaded intravenous lipid microspheres with low toxicity.

Science.gov (United States)

Lin, Xia; Zhang, Bo; Zhang, Keru; Zhang, Yu; Wang, Juan; Qi, Na; Yang, Shenshen; He, Haibing; Tang, Xing

2012-12-01

The aim of this study was to perform a systematic preclinical evaluation of norcantharidin (NCTD)-loaded intravenous lipid microspheres (NLM). Pharmacokinetics, biodistribution, antitumor efficacy and drug safety assessment (including acute toxicity, subchronic toxicity, hemolysis testing, intravenous stimulation and injection anaphylaxis) of NLM were carried out in comparison with the commercial product disodium norcantharidate injection (NI). The pharmacokinetics of NLM in rats was similar to that of NI, and a non-linear correlation was observed between AUC and dose. A comparable antitumor efficacy of NLM and NI was observed in mice inoculated with A549, BEL7402 and BCAP-37 cell lines. It was worth noting that the NLM produced a lower drug concentration in heart compared with NI, and significantly reduced the cardiac and renal toxicity. The LD(50) of NLM was twice higher than that of NI. In NLM, over 80% of NCTD was loaded in the lipid phase or bound with phospholipids. Thus, NCTD was sequestered by direct contacting with body fluids and largely avoided distribution into tissues, consequently leading to significantly reduced cardiac and renal toxicity. These preclinical results suggested that NLM could be a useful potential carrier for parenteral administration of NCTD, while providing a superior safety profile.

TOXNET and Beyond: Using the National Library of Medicine's Environmental Health and Toxicology Portal

Energy Technology Data Exchange (ETDEWEB)

Templin-Branner, W.

2010-10-20

The National Library of Medicine's Environmental Health and Toxicology Portal provides access to numerous databases that can help you explore environmental chemicals and risks. TOXNET and Beyond: Using NLM's Environmental Health and Toxicology Portal conveys the fundamentals of searching the NLM's TOXNET system of databases in chemistry, toxicology, environmental health, and related fields. In addition to TOXNET, the course will highlight various resources available through the Environmental Health and Toxicology Portal.

Health sciences library outreach to family caregivers: a call to service.

Science.gov (United States)

Howrey, Mary M

2018-04-01

This commentary discusses the information needs of family caregivers and care recipients in the United States. Health sciences library services and outreach activities that support family caregivers include: (1) advocacy, (2) resource building, and (3) programming and education. Ethical issues related to the privacy and confidentiality of clients are outlined in the commentary for information service providers. Also, continuing professional education resources are identified to assist librarians in providing high-quality information services for this special family caregiver population, such as those designed by the National Library of Medicine (NLM) through the NLM 4 Caregivers program.

Health sciences library outreach to family caregivers: a call to service

Directory of Open Access Journals (Sweden)

Mary M. Howrey

2018-04-01

Full Text Available This commentary discusses the information needs of family caregivers and care recipients in the United States. Health sciences library services and outreach activities that support family caregivers include: (1 advocacy, (2 resource building, and (3 programming and education. Ethical issues related to the privacy and confidentiality of clients are outlined in the commentary for information service providers. Also, continuing professional education resources are identified to assist librarians in providing high-quality information services for this special family caregiver population, such as those designed by the National Library of Medicine (NLM through the NLM 4 Caregivers program.

The Visible Human Project of the National Library of Medicine: Remote access and distribution of a multi-gigabyte data set

Science.gov (United States)

Ackerman, Michael J.

1993-01-01

As part of the 1986 Long-Range Plan for the National Library of Medicine (NLM), the Planning Panel on Medical Education wrote that NLM should '...thoroughly and systematically investigate the technical requirements for and feasibility of instituting a biomedical images library.' The panel noted the increasing use of images in clinical practice and biomedical research. An image library would complement NLM's existing bibliographic and factual database services and would ideally be available through the same computer networks as are these current NLM services. Early in 1989, NLM's Board of Regents convened an ad hoc planning panel to explore possible roles for the NLM in the area of electronic image libraries. In its report to the Board of Regents, the NLM Planning Panel on Electronic Image Libraries recommended that 'NLM should undertake a first project building a digital image library of volumetric data representing a complete, normal adult male and female. This Visible Human Project will include digitized photographic images for cryosectioning, digital images derived from computerized tomography, and digital magnetic resonance images of cadavers.' The technologies needed to support digital high resolution image libraries, including rapid development; and that NLM encourage investigator-initiated research into methods for representing and linking spatial and textual information, structural informatics. The first part of the Visible Human Project is the acquisition of cross-sectional CT and MRI digital images and cross-sectional cryosectional photographic images of a representative male and female cadaver at an average of one millimeter intervals. The corresponding cross-sections in each of the three modalities are to be registerable with one another.

An historical overview of the National Network of Libraries of Medicine, 1985–2015

Science.gov (United States)

Speaker, Susan L.

2018-01-01

The National Network of Libraries of Medicine (NNLM), established as the Regional Medical Library Program in 1965, has a rich and remarkable history. The network’s first twenty years were documented in a detailed 1987 history by Alison Bunting, AHIP, FMLA. This article traces the major trends in the network’s development since then: reconceiving the Regional Medical Library staff as a “field force” for developing, marketing, and distributing a growing number of National Library of Medicine (NLM) products and services; subsequent expansion of outreach to health professionals who are unaffiliated with academic medical centers, particularly those in public health; the advent of the Internet during the 1990s, which brought the migration of NLM and NNLM resources and services to the World Wide Web, and a mandate to encourage and facilitate Internet connectivity in the network; and the further expansion of the NLM and NNLM mission to include providing consumer health resources to satisfy growing public demand. The concluding section discusses the many challenges that NNLM staff faced as they transformed the network from a system that served mainly academic medical researchers to a larger, denser organization that offers health information resources to everyone. PMID:29632439

An historical overview of the National Network of Libraries of Medicine, 1985-2015.

Science.gov (United States)

Speaker, Susan L

2018-04-01

The National Network of Libraries of Medicine (NNLM), established as the Regional Medical Library Program in 1965, has a rich and remarkable history. The network's first twenty years were documented in a detailed 1987 history by Alison Bunting, AHIP, FMLA. This article traces the major trends in the network's development since then: reconceiving the Regional Medical Library staff as a "field force" for developing, marketing, and distributing a growing number of National Library of Medicine (NLM) products and services; subsequent expansion of outreach to health professionals who are unaffiliated with academic medical centers, particularly those in public health; the advent of the Internet during the 1990s, which brought the migration of NLM and NNLM resources and services to the World Wide Web, and a mandate to encourage and facilitate Internet connectivity in the network; and the further expansion of the NLM and NNLM mission to include providing consumer health resources to satisfy growing public demand. The concluding section discusses the many challenges that NNLM staff faced as they transformed the network from a system that served mainly academic medical researchers to a larger, denser organization that offers health information resources to everyone.

Is primary Sjögren’s syndrome a risk factor for malignancies different from lymphomas? What does the literature highlight about it?

Directory of Open Access Journals (Sweden)

Ciro Manzo

2017-07-01

Full Text Available Background : Primary Sjögren’s syndrome (pSS is a chronic systemic autoimmune disease with an elevated risk of developing lymphoproliferative malignancies (LM. Whether pSS is a risk factor or not for non-lymphoma malignancies (NLM has been scarcely evaluated in the literature. Age is per se a risk factor for malignancies: patients over 70 years old have 4 times higher risk for cancers than adults. Even if the mean age of pSS onset usually is in the 4th and 5th decade, its onset in patients aged over 65 years (Elderly Onset pSS – EOpSS is not uncommon. Material and methods : To evaluate pSS as a risk factor for NLM we performed a systematic electronic search on PubMed in the period 2006–2016 to identify all the publications on this topic. The studies were eligible for inclusion if they reported specific Standardized Incidence Ratio (SIR with 95% CI. Studies that did not report sufficient published and/or original data were excluded. Results : Only 7 articles of 494 that we found in PubMed fulfilled the inclusion criterion. In the vast majority of these, SIR values were not statistically significant for NLM. The occurrence of NLM after LM was statistically significant in some studies and a NLM represented the most frequent cause of death. The possibility that NLM may represent a paraneoplastic syndrome seems much more frequent than LM, the risk of which increases with time after the diagnosis. Data regarding the neoplastic weight of EOpSS are mainly pointed out by case reports. Conclusions : Primary Sjögren’s syndrome is not associated with an increased risk for NLM. However the possibility that NLM may appear after recovery from lymphoma should be carefully considered because it could be cause of the patient’s death. Similarly the possibility that NLM may represent a paraneoplastic syndrome must be highlighted. The relationship between EOpSS and SIRs for NLM should be deepened with studies on ad hoc cohorts.

MO-FG-204-03: Using Edge-Preserving Algorithm for Significantly Improved Image-Domain Material Decomposition in Dual Energy CT

International Nuclear Information System (INIS)

Zhao, W; Niu, T; Xing, L; Xiong, G; Elmore, K; Min, J; Zhu, J; Wang, L

2015-01-01

Purpose: To significantly improve dual energy CT (DECT) imaging by establishing a new theoretical framework of image-domain material decomposition with incorporation of edge-preserving techniques. Methods: The proposed algorithm, HYPR-NLM, combines the edge-preserving non-local mean filter (NLM) with the HYPR-LR (Local HighlY constrained backPRojection Reconstruction) framework. Image denoising using HYPR-LR framework depends on the noise level of the composite image which is the average of the different energy images. For DECT, the composite image is the average of high- and low-energy images. To further reduce noise, one may want to increase the window size of the filter of the HYPR-LR, leading resolution degradation. By incorporating the NLM filtering and the HYPR-LR framework, HYPR-NLM reduces the boost material decomposition noise using energy information redundancies as well as the non-local mean. We demonstrate the noise reduction and resolution preservation of the algorithm with both iodine concentration numerical phantom and clinical patient data by comparing the HYPR-NLM algorithm to the direct matrix inversion, HYPR-LR and iterative image-domain material decomposition (Iter-DECT). Results: The results show iterative material decomposition method reduces noise to the lowest level and provides improved DECT images. HYPR-NLM significantly reduces noise while preserving the accuracy of quantitative measurement and resolution. For the iodine concentration numerical phantom, the averaged noise levels are about 2.0, 0.7, 0.2 and 0.4 for direct inversion, HYPR-LR, Iter- DECT and HYPR-NLM, respectively. For the patient data, the noise levels of the water images are about 0.36, 0.16, 0.12 and 0.13 for direct inversion, HYPR-LR, Iter-DECT and HYPR-NLM, respectively. Difference images of both HYPR-LR and Iter-DECT show edge effect, while no significant edge effect is shown for HYPR-NLM, suggesting spatial resolution is well preserved for HYPR-NLM. Conclusion: HYPR-NLM

United States National Library of Medicine Drug Information Portal.

Science.gov (United States)

Hochstein, Colette; Goshorn, Jeanne; Chang, Florence

2009-01-01

The Drug Information Portal is a free Web resource from the National Library of Medicine (NLM) that provides a user-friendly gateway to current information for more than 15,000 drugs. The site guides users to related resources of NLM, the National Institutes of Health (NIH), and other government agencies. Current drug-related information regarding consumer health, clinical trials, AIDS, MeSH pharmacological actions, MEDLINE/PubMed biomedical literature, and physical properties and structure is easily retrieved by searching on a drug name. A varied selection of focused topics in medicine and drugs is also available from displayed subject headings. This column provides background information about the Drug Information Portal, as well as search basics.

An historical overview of the National Network of Libraries of Medicine, 1985–2015

Directory of Open Access Journals (Sweden)

Susan L. Speaker

2018-04-01

Full Text Available The National Network of Libraries of Medicine (NNLM, established as the Regional Medical Library Program in 1965, has a rich and remarkable history. The network’s first twenty years were documented in a detailed 1987 history by Alison Bunting, AHIP, FMLA. This article traces the major trends in the network’s development since then: reconceiving the Regional Medical Library staff as a “field force” for developing, marketing, and distributing a growing number of National Library of Medicine (NLM products and services; subsequent expansion of outreach to health professionals who are unaffiliated with academic medical centers, particularly those in public health; the advent of the Internet during the 1990s, which brought the migration of NLM and NNLM resources and services to the World Wide Web, and a mandate to encourage and facilitate Internet connectivity in the network; and the further expansion of the NLM and NNLM mission to include providing consumer health resources to satisfy growing public demand. The concluding section discusses the many challenges that NNLM staff faced as they transformed the network from a system that served mainly academic medical researchers to a larger, denser organization that offers health information resources to everyone.  This article has been approved for the Medical Library Association’s Independent Reading Program.

Learning about Marfan Syndrome

Science.gov (United States)

... Additional Resources for Marfan Syndrome What is Marfan syndrome? Marfan syndrome is one of the most common inherited ... FAQ Top of page Additional Resources For Marfan Syndrome Marfan syndrome [nlm.nih.gov] From Medline Plus Marfan ...

Adaptive nonlocal means filtering based on local noise level for CT denoising

International Nuclear Information System (INIS)

Li, Zhoubo; Trzasko, Joshua D.; Lake, David S.; Blezek, Daniel J.; Manduca, Armando; Yu, Lifeng; Fletcher, Joel G.; McCollough, Cynthia H.

2014-01-01

Purpose: To develop and evaluate an image-domain noise reduction method based on a modified nonlocal means (NLM) algorithm that is adaptive to local noise level of CT images and to implement this method in a time frame consistent with clinical workflow. Methods: A computationally efficient technique for local noise estimation directly from CT images was developed. A forward projection, based on a 2D fan-beam approximation, was used to generate the projection data, with a noise model incorporating the effects of the bowtie filter and automatic exposure control. The noise propagation from projection data to images was analytically derived. The analytical noise map was validated using repeated scans of a phantom. A 3D NLM denoising algorithm was modified to adapt its denoising strength locally based on this noise map. The performance of this adaptive NLM filter was evaluated in phantom studies in terms of in-plane and cross-plane high-contrast spatial resolution, noise power spectrum (NPS), subjective low-contrast spatial resolution using the American College of Radiology (ACR) accreditation phantom, and objective low-contrast spatial resolution using a channelized Hotelling model observer (CHO). Graphical processing units (GPU) implementation of this noise map calculation and the adaptive NLM filtering were developed to meet demands of clinical workflow. Adaptive NLM was piloted on lower dose scans in clinical practice. Results: The local noise level estimation matches the noise distribution determined from multiple repetitive scans of a phantom, demonstrated by small variations in the ratio map between the analytical noise map and the one calculated from repeated scans. The phantom studies demonstrated that the adaptive NLM filter can reduce noise substantially without degrading the high-contrast spatial resolution, as illustrated by modulation transfer function and slice sensitivity profile results. The NPS results show that adaptive NLM denoising preserves the

Assessment of prior image induced nonlocal means regularization for low-dose CT reconstruction: Change in anatomy.

Science.gov (United States)

Zhang, Hao; Ma, Jianhua; Wang, Jing; Moore, William; Liang, Zhengrong

2017-09-01

Repeated computed tomography (CT) scans are prescribed for some clinical applications such as lung nodule surveillance. Several studies have demonstrated that incorporating a high-quality prior image into the reconstruction of subsequent low-dose CT (LDCT) acquisitions can either improve image quality or reduce data fidelity requirements. Our proposed previous normal-dose image induced nonlocal means (ndiNLM) regularization method for LDCT is an example of such a method. However, one major concern with prior image based methods is that they might produce false information when the prior image and the current LDCT image show different structures (for example, if a lung nodule emerges, grows, shrinks, or disappears over time). This study aims to assess the performance of the ndiNLM regularization method in situations with change in anatomy. We incorporated the ndiNLM regularization into the statistical image reconstruction (SIR) framework for reconstruction of subsequent LDCT images. Because of its patch-based search mechanism, a rough registration between the prior image and the current LDCT image is adequate for the SIR-ndiNLM method. We assessed the performance of the SIR-ndiNLM method in lung nodule surveillance for two different scenarios: (a) the nodule was not found in a baseline exam but appears in a follow-up LDCT scan; (b) the nodule was present in a baseline exam but disappears in a follow-up LDCT scan. We further investigated the effect of nodule size on the performance of the SIR-ndiNLM method. We found that a relatively large search-window (e.g., 33 × 33) should be used for the SIR-ndiNLM method to account for misalignment between the prior image and the current LDCT image, and to ensure that enough similar patches can be found in the prior image. With proper selection of other parameters, experimental results with two patient datasets demonstrated that the SIR-ndiNLM method did not miss true nodules nor introduce false nodules in the lung nodule

Semantic Knowledge Representation (SKR) API

Data.gov (United States)

U.S. Department of Health & Human Services — The SKR Project was initiated at NLM in order to develop programs to provide usable semantic representation of biomedical free text by building on resources...

ChemIDplus

Data.gov (United States)

U.S. Department of Health & Human Services — Chemical database is a dictionary of over 400,000 chemicals (names, synonyms, and structures). ChemIDplus includes links to NLM and other databases and resources,...

Morphine overdose

Science.gov (United States)

... tests Chest x-ray EKG (electrocardiogram, or heart tracing) Fluids through a vein (IV) Laxative Naloxone, a ... Toxicology Data Network. Morphine. Toxnet.nlm.nih.gov Web site. toxnet.nlm.nih.gov/cgi-bin/sis/ ...

Privacy Policy

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... Home → NLM Privacy Policy URL of this page: https://medlineplus.gov/privacy.html NLM Privacy Policy To ... out of cookies in the most popular browsers, http://www.usa.gov/optout_instructions.shtml. Please note ...

National Library of Medicine

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... Find, Read, Learn Search biomedical literature Find medical terminologies Search NLM collections Read about diseases Learn about drugs Explore history Find a clinical trial Use a medical dictionary Find free full-text articles Explore NLM About ...

National Center for Biotechnology Information Celebrates 25th Anniversary | NIH MedlinePlus the Magazine

Science.gov (United States)

... page please turn JavaScript on. National Center for Biotechnology Information Celebrates 25th Anniversary Past Issues / Winter 2014 ... Photo courtesy of NLM The National Center for Biotechnology Information (NCBI), a component of NLM, celebrated its ...

Stemcell Information: SKIP000788 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available n JA, Hallmayer J, Dolmetsch RE Nature--Nature 2011--2011 471--471 7337--7337 230-4--230-4 http://www.ncbi.nlm.nih.gov/pubmed/21307850--http://www.ncbi.nlm.nih.gov/pubmed/21307850 -- ...

Low-dose computed tomography image restoration using previous normal-dose scan

International Nuclear Information System (INIS)

Ma, Jianhua; Huang, Jing; Feng, Qianjin; Zhang, Hua; Lu, Hongbing; Liang, Zhengrong; Chen, Wufan

2011-01-01

Purpose: In current computed tomography (CT) examinations, the associated x-ray radiation dose is of a significant concern to patients and operators. A simple and cost-effective means to perform the examinations is to lower the milliampere-seconds (mAs) or kVp parameter (or delivering less x-ray energy to the body) as low as reasonably achievable in data acquisition. However, lowering the mAs parameter will unavoidably increase data noise and the noise would propagate into the CT image if no adequate noise control is applied during image reconstruction. Since a normal-dose high diagnostic CT image scanned previously may be available in some clinical applications, such as CT perfusion imaging and CT angiography (CTA), this paper presents an innovative way to utilize the normal-dose scan as a priori information to induce signal restoration of the current low-dose CT image series. Methods: Unlike conventional local operations on neighboring image voxels, nonlocal means (NLM) algorithm utilizes the redundancy of information across the whole image. This paper adapts the NLM to utilize the redundancy of information in the previous normal-dose scan and further exploits ways to optimize the nonlocal weights for low-dose image restoration in the NLM framework. The resulting algorithm is called the previous normal-dose scan induced nonlocal means (ndiNLM). Because of the optimized nature of nonlocal weights calculation, the ndiNLM algorithm does not depend heavily on image registration between the current low-dose and the previous normal-dose CT scans. Furthermore, the smoothing parameter involved in the ndiNLM algorithm can be adaptively estimated based on the image noise relationship between the current low-dose and the previous normal-dose scanning protocols. Results: Qualitative and quantitative evaluations were carried out on a physical phantom as well as clinical abdominal and brain perfusion CT scans in terms of accuracy and resolution properties. The gain by the use

Beta Blockers for the Prevention of Acute Exacerbations of COPD

Science.gov (United States)

2017-10-01

Lazarus, SC; Criner, GJ; Dransfield, MT PMID: 27267111 URL - http://www.ncbi.nlm.nih.gov/ pubmed /27267111?dopt=Citation acknowledgement of federal...MT PMID: 27267111 URL - http://www.ncbi.nlm.nih.gov/ pubmed /27267111?dopt=Citation Patents: N/A Funding Obtained: N/A Key Accomplishments

76 FR 29773 - Call for Participation in Pillbox Patient-Safety Initiative

Science.gov (United States)

2011-05-23

... Pillbox Patient-Safety Initiative ACTION: Notice. SUMMARY: The National Library of Medicine (NLM) invites..., production version of Pillbox. This initiative is an important element of ongoing efforts to enhance patient.... SUPPLEMENTARY INFORMATION: NLM has established Pillbox, an initiative to enhance patient safety, by making...

New microsatellite markers classifying nontoxic and toxic Jatropha ...

Indian Academy of Sciences (India)

2009-04-03

Currently, the only way to iden- tify the high and low ... Materials and methods. More co-dominant ... (http://www/ncbi.nlm.nih.gov/projects/dbEST/) available as on April 3, 2009. .... lar characterization of Jatropha genetic resources through inter-.

75 FR 25864 - Submission for OMB Review; Comment Request; Lost People Finder System

Science.gov (United States)

2010-05-10

... Paperwork Reduction Act of 1995, the National Library of Medicine (NLM), the National Institutes of Health... Collection: The National Library of Medicine (NLM) proposes the continuation of a voluntary collection of... as part of its mission to develop and coordinate communication technologies to improve the delivery...

WE-FG-207B-03: Multi-Energy CT Reconstruction with Spatial Spectral Nonlocal Means Regularization

Energy Technology Data Exchange (ETDEWEB)

Li, B [University of Texas Southwestern Medical Center, Dallas, TX (United States); Southern Medical University, Guangzhou, Guangdong (China); Shen, C; Ouyang, L; Yang, M; Jiang, S; Jia, X [University of Texas Southwestern Medical Center, Dallas, TX (United States); Zhou, L [Southern Medical University, Guangzhou, Guangdong (China)

2016-06-15

Purpose: Multi-energy computed tomography (MECT) is an emerging application in medical imaging due to its ability of material differentiation and potential for molecular imaging. In MECT, image correlations at different spatial and channels exist. It is desirable to incorporate these correlations in reconstruction to improve image quality. For this purpose, this study proposes a MECT reconstruction technique that employes spatial spectral non-local means (ssNLM) regularization. Methods: We consider a kVp-switching scanning method in which source energy is rapidly switched during data acquisition. For each energy channel, this yields projection data acquired at a number of angles, whereas projection angles among channels are different. We formulate the reconstruction task as an optimziation problem. A least square term enfores data fidelity. A ssNLM term is used as regularization to encourage similarities among image patches at different spatial locations and channels. When comparing image patches at different channels, intensity difference were corrected by a transformation estimated via histogram equalization during the reconstruction process. Results: We tested our method in a simulation study with a NCAT phantom and an experimental study with a Gammex phantom. For comparison purpose, we also performed reconstructions using conjugate-gradient least square (CGLS) method and conventional NLM method that only considers spatial correlation in an image. ssNLM is able to better suppress streak artifacts. The streaks are along different projection directions in images at different channels. ssNLM discourages this dissimilarity and hence removes them. True image structures are preserved in this process. Measurements in regions of interests yield 1.1 to 3.2 and 1.5 to 1.8 times higher contrast to noise ratio than the NLM approach. Improvements over CGLS is even more profound due to lack of regularization in the CGLS method and hence amplified noise. Conclusion: The

Behaviour of veterinary drugs in soil, plant and water system : transport investigation of antiparasitic drugs in soil-plant-water

OpenAIRE

Islam, Marivil Dabalus

2013-01-01

submitted by Marivil Dabalus Islam Zsfassung in dt. Sprache Wien, Univ. für Bodenkultur, Diss., 2013 OeBB Food Addit http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22827314 / http://www.ncbi.nlm.nih.gov/pubmed/23581460

Communication Strategy: Proper Structure Necessary but not Sufficient

Science.gov (United States)

2010-12-01

Information, (1998), http://www.ncbi.nlm.nih.gov/ bookshelf /br.fcgi?book=nap6200&part=a20006484ddd00073 (accessed November 12, 2010). “The multidimensional...Biotechnology Information (1998). http://www.ncbi.nlm.nih.gov/ bookshelf /br.fcgi?book=nap6200&part=a20006484ddd000 73 (accessed November 12, 2010

77 FR 72985 - Health Information Technology: Revisions to the 2014 Edition Electronic Health Record...

Science.gov (United States)

2012-12-07

... period to replace the Data Element Catalog (DEC) standard and the Quality Reporting Document Architecture... our colleagues at the National Library of Medicine (NLM), a new version of the DEC (version 1.1) \\2...Measures.html . \\2\\ http://www.nlm.nih.gov/healthit/dec/ . 2. Quality Reporting Document Architecture (QRDA...

Growth performance and immunity status of starter broiler birds ...

African Journals Online (AJOL)

This study was conducted to investigate the effects of feeding diets containing Neem Leaf Meal (NLM), Garlic Meal (GM) and their combinations (NLM + GM) on growth performance and serum parameters of starter broiler birds. A total of 180 day-old Cobb broiler chickens were divided into twelve groups of fifteen chicks with ...

Response of finishing broiler chickens to supplemental Neem ...

African Journals Online (AJOL)

An eight weeks feeding trial was conducted to investigate the effects of feeding diets containing Neem Leaf Meal (NLM), Garlic Meal (GM) and their combinations (NLM +GM) on oocyst count, bacteria count and gut morphology of finishing broiler chickens. A total of 180 day-old Cobb broiler chickens were divided into twelve ...

Non-local means denoising of dynamic PET images.

Directory of Open Access Journals (Sweden)

Joyita Dutta

Full Text Available Dynamic positron emission tomography (PET, which reveals information about both the spatial distribution and temporal kinetics of a radiotracer, enables quantitative interpretation of PET data. Model-based interpretation of dynamic PET images by means of parametric fitting, however, is often a challenging task due to high levels of noise, thus necessitating a denoising step. The objective of this paper is to develop and characterize a denoising framework for dynamic PET based on non-local means (NLM.NLM denoising computes weighted averages of voxel intensities assigning larger weights to voxels that are similar to a given voxel in terms of their local neighborhoods or patches. We introduce three key modifications to tailor the original NLM framework to dynamic PET. Firstly, we derive similarities from less noisy later time points in a typical PET acquisition to denoise the entire time series. Secondly, we use spatiotemporal patches for robust similarity computation. Finally, we use a spatially varying smoothing parameter based on a local variance approximation over each spatiotemporal patch.To assess the performance of our denoising technique, we performed a realistic simulation on a dynamic digital phantom based on the Digimouse atlas. For experimental validation, we denoised [Formula: see text] PET images from a mouse study and a hepatocellular carcinoma patient study. We compared the performance of NLM denoising with four other denoising approaches - Gaussian filtering, PCA, HYPR, and conventional NLM based on spatial patches.The simulation study revealed significant improvement in bias-variance performance achieved using our NLM technique relative to all the other methods. The experimental data analysis revealed that our technique leads to clear improvement in contrast-to-noise ratio in Patlak parametric images generated from denoised preclinical and clinical dynamic images, indicating its ability to preserve image contrast and high

Non-local means denoising of dynamic PET images.

Science.gov (United States)

Dutta, Joyita; Leahy, Richard M; Li, Quanzheng

2013-01-01

Dynamic positron emission tomography (PET), which reveals information about both the spatial distribution and temporal kinetics of a radiotracer, enables quantitative interpretation of PET data. Model-based interpretation of dynamic PET images by means of parametric fitting, however, is often a challenging task due to high levels of noise, thus necessitating a denoising step. The objective of this paper is to develop and characterize a denoising framework for dynamic PET based on non-local means (NLM). NLM denoising computes weighted averages of voxel intensities assigning larger weights to voxels that are similar to a given voxel in terms of their local neighborhoods or patches. We introduce three key modifications to tailor the original NLM framework to dynamic PET. Firstly, we derive similarities from less noisy later time points in a typical PET acquisition to denoise the entire time series. Secondly, we use spatiotemporal patches for robust similarity computation. Finally, we use a spatially varying smoothing parameter based on a local variance approximation over each spatiotemporal patch. To assess the performance of our denoising technique, we performed a realistic simulation on a dynamic digital phantom based on the Digimouse atlas. For experimental validation, we denoised [Formula: see text] PET images from a mouse study and a hepatocellular carcinoma patient study. We compared the performance of NLM denoising with four other denoising approaches - Gaussian filtering, PCA, HYPR, and conventional NLM based on spatial patches. The simulation study revealed significant improvement in bias-variance performance achieved using our NLM technique relative to all the other methods. The experimental data analysis revealed that our technique leads to clear improvement in contrast-to-noise ratio in Patlak parametric images generated from denoised preclinical and clinical dynamic images, indicating its ability to preserve image contrast and high intensity details while

Rapid computation of single PET scan rest-stress myocardial blood flow parametric images by table look up.

Science.gov (United States)

Guehl, Nicolas J; Normandin, Marc D; Wooten, Dustin W; Rozen, Guy; Ruskin, Jeremy N; Shoup, Timothy M; Woo, Jonghye; Ptaszek, Leon M; Fakhri, Georges El; Alpert, Nathaniel M

2017-09-01

We have recently reported a method for measuring rest-stress myocardial blood flow (MBF) using a single, relatively short, PET scan session. The method requires two IV tracer injections, one to initiate rest imaging and one at peak stress. We previously validated absolute flow quantitation in ml/min/cc for standard bull's eye, segmental analysis. In this work, we extend the method for fast computation of rest-stress MBF parametric images. We provide an analytic solution to the single-scan rest-stress flow model which is then solved using a two-dimensional table lookup method (LM). Simulations were performed to compare the accuracy and precision of the lookup method with the original nonlinear method (NLM). Then the method was applied to 16 single scan rest/stress measurements made in 12 pigs: seven studied after infarction of the left anterior descending artery (LAD) territory, and nine imaged in the native state. Parametric maps of rest and stress MBF as well as maps of left (f LV ) and right (f RV ) ventricular spill-over fractions were generated. Regions of interest (ROIs) for 17 myocardial segments were defined in bull's eye fashion on the parametric maps. The mean of each ROI was then compared to the rest (K 1r ) and stress (K 1s ) MBF estimates obtained from fitting the 17 regional TACs with the NLM. In simulation, the LM performed as well as the NLM in terms of precision and accuracy. The simulation did not show that bias was introduced by the use of a predefined two-dimensional lookup table. In experimental data, parametric maps demonstrated good statistical quality and the LM was computationally much more efficient than the original NLM. Very good agreement was obtained between the mean MBF calculated on the parametric maps for each of the 17 ROIs and the regional MBF values estimated by the NLM (K 1map LM  = 1.019 × K 1 ROI NLM  + 0.019, R 2  = 0.986; mean difference = 0.034 ± 0.036 mL/min/cc). We developed a table lookup method for fast

Public library consumer health information pilot project: results of a National Library of Medicine evaluation.

Science.gov (United States)

Wood, F B; Lyon, B; Schell, M B; Kitendaugh, P; Cid, V H; Siegel, E R

2000-10-01

In October 1998, the National Library of Medicine (NLM) launched a pilot project to learn about the role of public libraries in providing health information to the public and to generate information that would assist NLM and the National Network of Libraries of Medicine (NN/LM) in learning how best to work with public libraries in the future. Three regional medical libraries (RMLs), eight resource libraries, and forty-one public libraries or library systems from nine states and the District of Columbia were selected for participation. The pilot project included an evaluation component that was carried out in parallel with project implementation. The evaluation ran through September 1999. The results of the evaluation indicated that participating public librarians were enthusiastic about the training and information materials provided as part of the project and that many public libraries used the materials and conducted their own outreach to local communities and groups. Most libraries applied the modest funds to purchase additional Internet-accessible computers and/or upgrade their health-reference materials. However, few of the participating public libraries had health information centers (although health information was perceived as a top-ten or top-five topic of interest to patrons). Also, the project generated only minimal usage of NLM's consumer health database, known as MEDLINEplus, from the premises of the monitored libraries (patron usage from home or office locations was not tracked). The evaluation results suggested a balanced follow-up by NLM and the NN/LM, with a few carefully selected national activities, complemented by a package of targeted activities that, as of January 2000, are being planned, developed, or implemented. The results also highlighted the importance of building an evaluation component into projects like this one from the outset, to assure that objectives were met and that evaluative information was available on a timely basis, as was

SAIL: automating interlibrary loan.

Science.gov (United States)

Lacroix, E M

1994-01-01

The National Library of Medicine (NLM) initiated the System for Automated Interlibrary Loan (SAIL) pilot project to study the feasibility of using imaging technology linked to the DOCLINE system to deliver copies of journal articles. During the project, NLM converted a small number of print journal issues to electronic form, linking the captured articles to the MEDLINE citation unique identifier. DOCLINE requests for these journals that could not be filled by network libraries were routed to SAIL. Nearly 23,000 articles from sixty-four journals recently selected for indexing in Index Medicus were scanned to convert them to electronic images. During fiscal year 1992, 4,586 scanned articles were used to fill 10,444 interlibrary loan (ILL) requests, and more than half of these were used only once. Eighty percent of all the articles were not requested at all. The total cost per article delivered was $10.76, substantially more than it costs to process a photocopy request. Because conversion costs were the major component of the total SAIL cost, and most of the articles captured for the project were not requested, this model was not cost-effective. Data on SAIL journal article use was compared with all ILL requests filled by NLM for the same period. Eighty-eight percent of all articles requested from NLM were requested only once. The results of the SAIL project demonstrated that converting journal articles to electronic images and storing them in anticipation of repeated requests would not meet NLM's objective to improve interlibrary loan. PMID:8004020

Assessment of Blood Chemistry, Weight Gain and Linear Body Measurements of Pre-Puberal Buck Rabbits Fed Different Levels of Neem (Azadirachta indica A. Juss. Leaf Meals Evaluación de Química Sanguínea, Ganancia de Peso y Mediciones Corporales Lineales de Conejos Pre-Púberes Alimentados con Diferentes Niveles de Harina de Hojas de Neem (Azadirachta indica A. Juss.

Directory of Open Access Journals (Sweden)

I.P Ogbuewu

2010-09-01

Full Text Available A 16 week feeding trial was carried out to investigate the effect of dietary Neem (Azadirachta indica A. Juss. leaf meal (NLM on body weight gain, linear body measurements and blood chemistry of pre-puberal buck rabbits. Four treatment diets were formulated to contain the NLM at inclusion levels of 0 (control, 5, 10 and 15%. Thirty six crossbred New Zealand white × Chinchilla pre-puberal buck rabbits aged 5 to 6 mo were divided into four groups of nine rabbits and each group was further replicated into three of three rabbits each. The rabbits were randomly assigned to the four dietary treatments. Lymphocyte count of rabbits fed control diet (8.32 × 10(9 mm-3 was significantly higher than the group fed 15% NLM (4.60 × 10(9 mm-3. The mean cell hemoglobin (MCH and mean cell volume (MCV of the control bucks were significantly (p 0.05 among the treatment groups. The results suggest that buck rabbits could tolerate up to 15% dietary inclusion of NLM without deleterious effects on body weight gain, linear body measurements and some hematological parameters.Se realizó un ensayo de alimentación de 16 semanas para investigar el efecto de harina de hojas de neem Azadirachta indica A. Juss. (NML sobre ganancia de peso, mediciones corporales lineales y química sanguínea de conejos machos pre-púberes. Se formularon cuatro dietas con niveles de inclusión de NLM de 0 (control, 5, 10, y 15%. Treinta y seis conejos híbridos New Zealand white × Chinchilla, pre-púberes, de 5 a 6 meses, se distribuyeron en cuatro grupos de nueve conejos, y cada grupo fue repetido en tres grupos de tres conejos cada uno. Los conejos se asignaron aleatoriamente a las cuatro dietas tratamiento. El recuento de linfocitos de los conejos alimentados con la dieta control (8,32 × 10(9 mm-3 fue significativamente mayor que el grupo alimentado con 15% NLM (4,60 × 10(9 mm-3. La hemoglobina celular media (MCH y el volumen celular medio (MCV de los conejos control fueron

To Your Health: NLM Update—MedlinePlus

Science.gov (United States)

... illustrate health care May 7 2018 Transcript Genetic architecture of mental disorders April 30 2018 Transcript Why ... MedlinePlus Connect for EHRs For Developers U.S. National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894 ...

NLM at TREC 2012 Medical Records Track

Science.gov (United States)

2012-11-01

automatic runs are not significantly above the medians. As in 2011, we conclude that the existing search engines are mature enough to support cohort selection tasks, and the quality of the queries could be

Fungal genome resources at NCBI

Science.gov (United States)

Robbertse, B.; Tatusova, T.

2011-01-01

The National Center for Biotechnology Information (NCBI) is well known for the nucleotide sequence archive, GenBank and sequence analysis tool BLAST. However, NCBI integrates many types of biomolecular data from variety of sources and makes it available to the scientific community as interactive web resources as well as organized releases of bulk data. These tools are available to explore and compare fungal genomes. Searching all databases with Fungi [organism] at http://www.ncbi.nlm.nih.gov/ is the quickest way to find resources of interest with fungal entries. Some tools though are resources specific and can be indirectly accessed from a particular database in the Entrez system. These include graphical viewers and comparative analysis tools such as TaxPlot, TaxMap and UniGene DDD (found via UniGene Homepage). Gene and BioProject pages also serve as portals to external data such as community annotation websites, BioGrid and UniProt. There are many different ways of accessing genomic data at NCBI. Depending on the focus and goal of research projects or the level of interest, a user would select a particular route for accessing genomic databases and resources. This review article describes methods of accessing fungal genome data and provides examples that illustrate the use of analysis tools. PMID:22737589

Education resources of the National Center for Biotechnology Information.

Science.gov (United States)

Cooper, Peter S; Lipshultz, Dawn; Matten, Wayne T; McGinnis, Scott D; Pechous, Steven; Romiti, Monica L; Tao, Tao; Valjavec-Gratian, Majda; Sayers, Eric W

2010-11-01

The National Center for Biotechnology Information (NCBI) hosts 39 literature and molecular biology databases containing almost half a billion records. As the complexity of these data and associated resources and tools continues to expand, so does the need for educational resources to help investigators, clinicians, information specialists and the general public make use of the wealth of public data available at the NCBI. This review describes the educational resources available at NCBI via the NCBI Education page (www.ncbi.nlm.nih.gov/Education/). These resources include materials designed for new users, such as About NCBI and the NCBI Guide, as well as documentation, Frequently Asked Questions (FAQs) and writings on the NCBI Bookshelf such as the NCBI Help Manual and the NCBI Handbook. NCBI also provides teaching materials such as tutorials, problem sets and educational tools such as the Amino Acid Explorer, PSSM Viewer and Ebot. NCBI also offers training programs including the Discovery Workshops, webinars and tutorials at conferences. To help users keep up-to-date, NCBI produces the online NCBI News and offers RSS feeds and mailing lists, along with a presence on Facebook, Twitter and YouTube.

The Evolution of Veteran Affairs Healthcare - Is It High Time for Cannabis Treatment

Science.gov (United States)

2015-10-01

Neuropathic Pain in HIV, was later published with the National Center for Biotechnology Information and concluded that pain relief was greater with...www.nlm.nih.gov/medlineplus/ magazine /issues/winter09/articles/winter09pg10-14.html, (accessed September 2015). 56 U.S. Department of Veteran Affairs...Medline Plus, PTSD: A Growing Epidemic, https://www.nlm.nih.gov/medlineplus/ magazine /issues/winter09/articles/winter09pg10- 14.html, (accessed

Gene and genome duplications and the origin of C4 photosynthesis: Birth of a trait in the Cleomaceae

Directory of Open Access Journals (Sweden)

Erik van den Bergh

2014-08-01

DATA: The data deposited at NCBI represents raw RNA reads for each data series mentioned: 5 leaf stages, root, stem, stamen, petal, carpel, sepal, 3 seedling stages and 3 seed stages of Tarenaya hassleriana and Gynandropsis gynandra. The assembled reads were used for all analyses of this paper where RNA was used. http://www.ncbi.nlm.nih.gov/Traces/sra/?study=SRP036637, http://www.ncbi.nlm.nih.gov/Traces/sra/?study=SRP036837

Global visibility for global health: Is it time for a new descriptor in Medical Subject Heading (MeSH of MEDLINE/PubMed?

Directory of Open Access Journals (Sweden)

Ana Marušic´

2013-06-01

Full Text Available Despite a large body of research in global health (almost 9000 articles published in PubMed until 2012, the term “global health” is not included in the Medical Subject Headings (MeSH of the NLM – its controlled vocabulary thesaurus which NLM uses to index articles in MEDL INE. There are only 6 journals currently covered by PubMed which specialize in global health, including Journal of Global Health.

Use of Internet audience measurement data to gauge market share for online health information services.

Science.gov (United States)

Wood, Fred B; Benson, Dennis; LaCroix, Eve-Marie; Siegel, Elliot R; Fariss, Susan

2005-07-01

The transition to a largely Internet and Web-based environment for dissemination of health information has changed the health information landscape and the framework for evaluation of such activities. A multidimensional evaluative approach is needed. This paper discusses one important dimension of Web evaluation-usage data. In particular, we discuss the collection and analysis of external data on website usage in order to develop a better understanding of the health information (and related US government information) market space, and to estimate the market share or relative levels of usage for National Library of Medicine (NLM) and National Institutes of Health (NIH) websites compared to other health information providers. The primary method presented is Internet audience measurement based on Web usage by external panels of users and assembled by private vendors-in this case, comScore. A secondary method discussed is Web usage based on Web log software data. The principle metrics for both methods are unique visitors and total pages downloaded per month. NLM websites (primarily MedlinePlus and PubMed) account for 55% to 80% of total NIH website usage depending on the metric used. In turn, NIH.gov top-level domain usage (inclusive of NLM) ranks second only behind WebMD in the US domestic home health information market and ranks first on a global basis. NIH.gov consistently ranks among the top three or four US government top-level domains based on global Web usage. On a site-specific basis, the top health information websites in terms of global usage appear to be WebMD, MSN Health, PubMed, Yahoo! Health, AOL Health, and MedlinePlus. Based on MedlinePlus Web log data and external Internet audience measurement data, the three most heavily used cancer-centric websites appear to be www.cancer.gov (National Cancer Institute), www.cancer.org (American Cancer Society), and www.breastcancer.org (non-profit organization). Internet audience measurement has proven useful to NLM

Rapid virtual hematoxylin and eosin histology of breast tissue specimens using a compact fluorescence nonlinear microscope.

Science.gov (United States)

Cahill, Lucas C; Giacomelli, Michael G; Yoshitake, Tadayuki; Vardeh, Hilde; Faulkner-Jones, Beverly E; Connolly, James L; Sun, Chi-Kuang; Fujimoto, James G

2018-01-01

Up to 40% of patients undergoing breast conserving surgery for breast cancer require repeat surgeries due to close to or positive margins. The lengthy processing required for evaluating surgical margins by standard paraffin-embedded histology precludes its use during surgery and therefore, technologies for rapid evaluation of surgical pathology could improve the treatment of breast cancer by reducing the number of surgeries required. We demonstrate real-time histological evaluation of breast cancer surgical specimens by staining specimens with acridine orange (AO) and sulforhodamine 101 (SR101) analogously to hematoxylin and eosin (H&E) and then imaging the specimens with fluorescence nonlinear microscopy (NLM) using a compact femtosecond fiber laser. A video-rate computational light absorption model was used to produce realistic virtual H&E images of tissue in real time and in three dimensions. NLM imaging could be performed to depths of 100 μm below the tissue surface, which is important since many surgical specimens require subsurface evaluation due to contamination artifacts on the tissue surface from electrocautery, surgical ink, or debris from specimen handling. We validate this method by expert review of NLM images compared to formalin-fixed, paraffin-embedded (FFPE) H&E histology. Diagnostically important features such as normal terminal ductal lobular units, fibrous and adipose stromal parenchyma, inflammation, invasive carcinoma, and in situ lobular and ductal carcinoma were present in NLM images associated with pathologies identified on standard FFPE H&E histology. We demonstrate that AO and SR101 were extracted to undetectable levels after FFPE processing and fluorescence in situ hybridization (FISH) HER2 amplification status was unaffected by the NLM imaging protocol. This method potentially enables cost-effective, real-time histological guidance of surgical resections.

Use of information resources by the state of Tennessee in risk assessment applications

Energy Technology Data Exchange (ETDEWEB)

Bashor, B.S. [Tennessee Department of Health and Environment, Nashville (United States)

1990-12-31

The major resources used by the Bureau of Environment, and Environmental Epidemiology (EEP) for risk assessment are: the Integrated Risk Information System (IRIS), Health and Environmental Effects Summary Table (HEAST), Agency for Toxic Substances and disease Registry (ATSDR) Toxicological Profiles, databases at the National Library of Medicine (NLM), World Health Organization (WHO) ENvironmental Criteria, and documents that the Environmental Protection Agency (EPA) has published on Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) risk assessment activities. The Risk Assessment Review has been helpful in providing information about availability of new documents or information. No systematic method has been made available to us to locate information resources. IRIS User`s Support has been helpful in making appropriate and timely referrals. Most other EPA resources were located by serendipity and persistence. The CERCLA methodology for risk assessments is being used in environmental programs, and at present, one person is responsible for all risk assessment activities in the department, but plans are underway to train one or two people from each program area. 2 figs.

Federal Research and Development Funding: FY2017

Science.gov (United States)

2017-01-27

International Center (FIC) 70 70 National Library of Medicine (NLM) 396 396 Office of Director (OD) 1,571 1,716 Buildings & Facilities (B&F...operates the National Agricultural Library , one of the department’s primary information repositories for food, agriculture, and natural resource... Multicultural Scholars Program, Women and Minorities in STEM Program, Agriculture in the Classroom, and Secondary/Postsecondary Challenge Grants. For

Intraspecies comparative genomics of three strains of Orientia tsutsugamushi with different antibiotic sensitivity.

Science.gov (United States)

Liao, Hsiao-Mei; Chao, Chien-Chung; Lei, Haiyan; Li, Bingjie; Tsai, Shien; Hung, Guo-Chiuan; Ching, Wei-Mei; Lo, Shyh-Ching

2017-06-01

We recently reported the genome of Orientia tsutsugamushi (OT) strain Karp (GenBank Accession #: NZ_LYMA00000000.2, https://www.ncbi.nlm.nih.gov/nuccore/NZ_LYMA00000000.2) with > 2 Mb in size through clone-based sequencing and high throughput genomic shotgun sequencing (HTS). The genomes of OT strains AFSC4 and AFSC7 were similarly sequenced by HTS Since strains AFSC4 (GenBank Accession #: NZ_LYMT00000000.1, https://www.ncbi.nlm.nih.gov/nuccore/1035784408) and AFSC7 (GenBank Accession #: NZ_LYMB00000000.1, https://www.ncbi.nlm.nih.gov/nuccore/1035854767) were more resistant to antibiotics than strain Karp, we conducted comparative analysis of the three draft genomes annotated by RAST server aimed to identify possible genetic bases of difference in microbial antibiotic sensitivity. Intraspecies comparative genomics analysis of the three OT strains revealed that two ORFs encoding hypothetical proteins in both strains AFSC4 and AFSC7 are absent in strain Karp.

Comment on ;Evaluation of a physically based quasi-linear and a conceptually based nonlinear Muskingum methods; [J. Hydrol., 546, 437-449, 10.1016/j.jhydrol.2017.01.025

Science.gov (United States)

Barati, Reza

2017-07-01

Perumal et al. (2017) compared the performances of the variable parameter McCarthy-Muskingum (VPMM) model of Perumal and Price (2013) and the nonlinear Muskingum (NLM) model of Gill (1978) using hypothetical inflow hydrographs in an artificial channel. As input parameters, first model needs the initial condition, upstream boundary condition, Manning's roughness coefficient, length of the routing reach, cross-sections of the river reach and the bed slope, while the latter one requires the initial condition, upstream boundary condition and the hydrologic parameters (three parameters which can be calibrated using flood hydrographs of the upstream and downstream sections). The VPMM model was examined by available Manning's roughness values, whereas the NLM model was tested in both calibration and validation steps. As final conclusion, Perumal et al. (2017) claimed that the NLM model should be retired from the literature of the Muskingum model. While the author's intention is laudable, this comment examines some important issues in the subject matter of the original study.

To Your Health: NLM update transcript - Countering obesity

Science.gov (United States)

... The perspective's author explains the steady increase in obesity among Americans initially began in 1980. Edward Livingston M. ... pages devoted to: weight control ; body weight ; and obesity in children . Before I go, this reminder... MedlinePlus.gov is ...

MO-DE-207A-11: Sparse-View CT Reconstruction Via a Novel Non-Local Means Method

International Nuclear Information System (INIS)

Chen, Z; Qi, H; Wu, S; Xu, Y; Zhou, L

2016-01-01

Purpose: Sparse-view computed tomography (CT) reconstruction is an effective strategy to reduce the radiation dose delivered to patients. Due to its insufficiency of measurements, traditional non-local means (NLM) based reconstruction methods often lead to over-smoothness in image edges. To address this problem, an adaptive NLM reconstruction method based on rotational invariance (RIANLM) is proposed. Methods: The method consists of four steps: 1) Initializing parameters; 2) Algebraic reconstruction technique (ART) reconstruction using raw projection data; 3) Positivity constraint of the image reconstructed by ART; 4) Update reconstructed image by using RIANLM filtering. In RIANLM, a novel similarity metric that is rotational invariance is proposed and used to calculate the distance between two patches. In this way, any patch with similar structure but different orientation to the reference patch would win a relatively large weight to avoid over-smoothed image. Moreover, the parameter h in RIANLM which controls the decay of the weights is adaptive to avoid over-smoothness, while it in NLM is not adaptive during the whole reconstruction process. The proposed method is named as ART-RIANLM and validated on Shepp-Logan phantom and clinical projection data. Results: In our experiments, the searching neighborhood size is set to 15 by 15 and the similarity window is set to 3 by 3. For the simulated case with a resolution of 256 by 256 Shepp-Logan phantom, the ART-RIANLM produces higher SNR (35.38dB<24.00dB) and lower MAE (0.0006<0.0023) reconstructed image than ART-NLM. The visual inspection demonstrated that the proposed method could suppress artifacts or noises more effectively and preserve image edges better. Similar results were found for clinical data case. Conclusion: A novel ART-RIANLM method for sparse-view CT reconstruction is presented with superior image. Compared to the conventional ART-NLM method, the SNR and MAE from ART-RIANLM increases 47% and decreases 74

GPU-Based Block-Wise Nonlocal Means Denoising for 3D Ultrasound Images

Directory of Open Access Journals (Sweden)

Liu Li

2013-01-01

Full Text Available Speckle suppression plays an important role in improving ultrasound (US image quality. While lots of algorithms have been proposed for 2D US image denoising with remarkable filtering quality, there is relatively less work done on 3D ultrasound speckle suppression, where the whole volume data rather than just one frame needs to be considered. Then, the most crucial problem with 3D US denoising is that the computational complexity increases tremendously. The nonlocal means (NLM provides an effective method for speckle suppression in US images. In this paper, a programmable graphic-processor-unit- (GPU- based fast NLM filter is proposed for 3D ultrasound speckle reduction. A Gamma distribution noise model, which is able to reliably capture image statistics for Log-compressed ultrasound images, was used for the 3D block-wise NLM filter on basis of Bayesian framework. The most significant aspect of our method was the adopting of powerful data-parallel computing capability of GPU to improve the overall efficiency. Experimental results demonstrate that the proposed method can enormously accelerate the algorithm.

(Non-) homomorphic approaches to denoise intensity SAR images with non-local means and stochastic distances

Science.gov (United States)

Penna, Pedro A. A.; Mascarenhas, Nelson D. A.

2018-02-01

The development of new methods to denoise images still attract researchers, who seek to combat the noise with the minimal loss of resolution and details, like edges and fine structures. Many algorithms have the goal to remove additive white Gaussian noise (AWGN). However, it is not the only type of noise which interferes in the analysis and interpretation of images. Therefore, it is extremely important to expand the filters capacity to different noise models present in li-terature, for example the multiplicative noise called speckle that is present in synthetic aperture radar (SAR) images. The state-of-the-art algorithms in remote sensing area work with similarity between patches. This paper aims to develop two approaches using the non local means (NLM), developed for AWGN. In our research, we expanded its capacity for intensity SAR ima-ges speckle. The first approach is grounded on the use of stochastic distances based on the G0 distribution without transforming the data to the logarithm domain, like homomorphic transformation. It takes into account the speckle and backscatter to estimate the parameters necessary to compute the stochastic distances on NLM. The second method uses a priori NLM denoising with a homomorphic transformation and applies the inverse Gamma distribution to estimate the parameters that were used into NLM with stochastic distances. The latter method also presents a new alternative to compute the parameters for the G0 distribution. Finally, this work compares and analyzes the synthetic and real results of the proposed methods with some recent filters of the literature.

Clone DB: an integrated NCBI resource for clone-associated data

Science.gov (United States)

Schneider, Valerie A.; Chen, Hsiu-Chuan; Clausen, Cliff; Meric, Peter A.; Zhou, Zhigang; Bouk, Nathan; Husain, Nora; Maglott, Donna R.; Church, Deanna M.

2013-01-01

The National Center for Biotechnology Information (NCBI) Clone DB (http://www.ncbi.nlm.nih.gov/clone/) is an integrated resource providing information about and facilitating access to clones, which serve as valuable research reagents in many fields, including genome sequencing and variation analysis. Clone DB represents an expansion and replacement of the former NCBI Clone Registry and has records for genomic and cell-based libraries and clones representing more than 100 different eukaryotic taxa. Records provide details of library construction, associated sequences, map positions and information about resource distribution. Clone DB is indexed in the NCBI Entrez system and can be queried by fields that include organism, clone name, gene name and sequence identifier. Whenever possible, genomic clones are mapped to reference assemblies and their map positions provided in clone records. Clones mapping to specific genomic regions can also be searched for using the NCBI Clone Finder tool, which accepts queries based on sequence coordinates or features such as gene or transcript names. Clone DB makes reports of library, clone and placement data on its FTP site available for download. With Clone DB, users now have available to them a centralized resource that provides them with the tools they will need to make use of these important research reagents. PMID:23193260

Phase-correcting non-local means filtering for diffusion-weighted imaging of the spinal cord.

Science.gov (United States)

Kafali, Sevgi Gokce; Çukur, Tolga; Saritas, Emine Ulku

2018-02-09

DWI suffers from low SNR when compared to anatomical MRI. To maintain reasonable SNR at relatively high spatial resolution, multiple acquisitions must be averaged. However, subject motion or involuntary physiological motion during diffusion-sensitizing gradients cause phase offsets among acquisitions. When the motion is localized to a small region, these phase offsets become particularly problematic. Complex averaging of acquisitions lead to cancellations from these phase offsets, whereas magnitude averaging results in noise amplification. Here, we propose an improved reconstruction for multi-acquisition DWI that effectively corrects for phase offsets while reducing noise. Each acquisition is processed with a refocusing reconstruction for global phase correction and a partial k-space reconstruction via projection-onto-convex-sets (POCS). The proposed reconstruction then embodies a new phase-correcting non-local means (PC-NLM) filter. PC-NLM is performed on the complex-valued outputs of the POCS algorithm aggregated across acquisitions. The PC-NLM filter leverages the shared structure among multiple acquisitions to simultaneously alleviate nuisance factors including phase offsets and noise. Extensive simulations and in vivo DWI experiments of the cervical spinal cord are presented. The results demonstrate that the proposed reconstruction improves image quality by mitigating signal loss because of phase offsets and reducing noise. Importantly, these improvements are achieved while preserving the accuracy of apparent diffusion coefficient maps. An improved reconstruction incorporating a PC-NLM filter for multi-acquisition DWI is presented. This reconstruction can be particularly beneficial for high-resolution or high-b-value DWI acquisitions that suffer from low SNR and phase offsets from local motion. © 2018 International Society for Magnetic Resonance in Medicine.

CITE NLM: Natural-Language Searching in an Online Catalog.

Science.gov (United States)

Doszkocs, Tamas E.

1983-01-01

The National Library of Medicine's Current Information Transfer in English public access online catalog offers unique subject search capabilities--natural-language query input, automatic medical subject headings display, closest match search strategy, ranked document output, dynamic end user feedback for search refinement. References, description…

The NCBI BioSystems database.

Science.gov (United States)

Geer, Lewis Y; Marchler-Bauer, Aron; Geer, Renata C; Han, Lianyi; He, Jane; He, Siqian; Liu, Chunlei; Shi, Wenyao; Bryant, Stephen H

2010-01-01

The NCBI BioSystems database, found at http://www.ncbi.nlm.nih.gov/biosystems/, centralizes and cross-links existing biological systems databases, increasing their utility and target audience by integrating their pathways and systems into NCBI resources. This integration allows users of NCBI's Entrez databases to quickly categorize proteins, genes and small molecules by metabolic pathway, disease state or other BioSystem type, without requiring time-consuming inference of biological relationships from the literature or multiple experimental datasets.

3D imaging of hematoxylin and eosin stained thick tissues with a sub-femtoliter resolution by using Cr:forsterite-laser-based nonlinear microscopy (Conference Presentation)

Science.gov (United States)

Kao, Chien-Ting; Wei, Ming-Liang; Liao, Yi-Hua; Sun, Chi-Kuang

2017-02-01

Intraoperative assessment of excision tissues during cancer surgery is clinically important. The assessment is used to be guided by the examination for residual tumor with frozen pathology, while it is time consuming for preparation and is with low accuracy for diagnosis. Recently, reflection confocal microscopy (RCM) and nonlinear microscopy (NLM) were demonstrated to be promising methods for surgical border assessment. Intraoperative RCM imaging may enable detection of residual tumor directly on skin cancers patients during Mohs surgery. The assessment of benign and malignant breast pathologies in fresh surgical specimens was demonstrated by NLM. Without using hematoxylin and eosin (H and E) that are common dyes for histopathological diagnosis, RCM was proposed to image in vivo by using aluminum chloride for nuclear contrast on surgical wounds directly, while NLM was proposed to detect two photon fluorescence nuclear contrast from acrdine orange staining. In this paper, we propose and demonstrate 3D imaging of H and E stained thick tissues with a sub-femtoliter resolution by using Cr:forsterite-laser-based NLM. With a 1260 nm femtosecond Cr:forsterite laser as the excitation source, the hematoxylin will strongly enhance the third-harmonic generation (THG) signals, while eosin will illuminate strong fluorescence under three photon absorption. Compared with previous works, the 1260 nm excitation light provide high penetration and low photodamage to the exercised tissues so that the possibility to perform other follow-up examination will be preserved. The THG and three-photon process provides high nonlinearity so that the super resolution in 3D is now possible. The staining and the contrast of the imaging is also fully compatible with the current clinical standard on frozen pathology thus facilitate the rapid intraoperative assessment of excision tissues. This work is sponsored by National Health Research Institutes and supported by National Taiwan University

LEOPARD syndrome

Science.gov (United States)

Multiple lentigines syndrome; Noonan syndrome with multiple lentigines ... Genetics Home Reference -- ghr.nlm.nih.gov/condition/noonan-syndrome-with-multiple-lentigines National Organization for Rare Disorders -- ...

Sequence Classification: 390305 [

Lifescience Database Archive (English)

Full Text Available SOMERASE I TOPA (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING ENZYME) (SWIVELASE) (TYPE I DNA TOPOISOMERASE) (NICKING-CLOSING ENZYME) || http://www.ncbi.nlm.nih.gov/protein/31794816 ...

Developmental and Reproductive Toxicology Database (DART)

Data.gov (United States)

U.S. Department of Health & Human Services — A bibliographic database on the National Library of Medicine's (NLM) Toxicology Data Network (TOXNET) with references to developmental and reproductive toxicology...

Sequence Classification: 889958 [

Lifescience Database Archive (English)

Full Text Available e-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion; Ino2p || http://www.ncbi.nlm.nih.gov/protein/6320328 ...

Sequence Classification: 889733 [

Lifescience Database Archive (English)

Full Text Available teracts with electron transport chain components and may influence respiration; human homolog involved in Friedrich's ataxia; Yfh1p || http://www.ncbi.nlm.nih.gov/protein/6320083 ...

Sequence Classification: 892097 [

Lifescience Database Archive (English)

Full Text Available into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes; Vps20p || http://www.ncbi.nlm.nih.gov/protein/6323723 ...

Sequence Classification: 889739 [

Lifescience Database Archive (English)

Full Text Available hosphatidylinositol-3-phosphate, involved in localization of membranes to the preautophagosome, potential Cdc28p substrate; Atg20p || http://www.ncbi.nlm.nih.gov/protein/6320090 ...

Sequence Classification: 779151 [

Lifescience Database Archive (English)

Full Text Available bnormal pharyngeal pumping EAT-5, innexin, required for synchronized pharyngeal muscle contraction and feeding (50.3 kD) (eat-5) || http://www.ncbi.nlm.nih.gov/protein/17506489 ...

Natural Disasters (Environmental Health Student Portal)

Science.gov (United States)

... be prepared. Games and Activities Stop Disasters (International Strategy for Disaster Reduction) - Online game to learn how to stop various disasters ... | Accessibility Videos and Players Contact Us: tehip@teh.nlm.nih. ...

Data policy and availability supporting global change research development, and decision making

International Nuclear Information System (INIS)

Carroll, B.C.; Jack, R.F.; Cotter, G.A.

1991-01-01

An explosion of information has created a crisis for today's information age. We must determine how to use the best available information resources, tools, and technology. To do this, we need to have leadership at the interagency level to promote a coherent information policy. It is also important to find ways to educate the users of information regarding the tools available to them. This paper reports that advances in technology have resulted in efforts to shift from disciplinary and mission-oriented systems to decision support systems and personalized information systems. One such effort is being made by the Interagency Working Group on Data Management for Global Change (IWGDMGC). Five federal agencies - the Department of Commerce (DOC), Department of Energy (DOE), National Aeronautics and Space Administration (NASA), National Library of Medicine (NLM), and Department of Defense (DoD) - have an ongoing cooperative information management group, Commerce, Energy, NASA, NLM, and Defense Information (CENDI), that is meeting the challenge of coordinating and integrating its information management systems. Although it is beginning to be technically feasible to have a system with text, bibliographic, and numeric data on-line for the user to manipulate at the user's own workstation, promoting its full development will require national recognition that the resource investment in such a system is worthwhile. It also requires close cooperation between the producers and users of the information - that is, the research and policy community and the information community. National resources need to be mobilized in a coordinated manner to move us into the next generation of information support systems

NLM MedlinePlus Magazine Team | NIH MedlinePlus the Magazine

Science.gov (United States)

... Robert George DIRECTOR OF OPERATIONS Carolyn Medeiros DIRECTOR, BUSINESS DEVELOPMENT Michele Tezduyar MANAGING EDITOR Emily Poe SENIOR ... MD 20814 CONNECT WITH US Follow us on Facebook Facebook MedlinePlus www.facebook.com/mplus.gov Facebook ...

To Your Health: NLM update transcript - Improving medical research rigor?

Science.gov (United States)

... gov's home page, then, click on 'understanding medical research (National Library of Medicine).' Before I go, this reminder... MedlinePlus.gov is authoritative. It's free. We do not accept advertising .... and is written to help you. To find ...

Sequence Classification: 488452 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH TMB TMB TMB TMB >gi|28869747|ref|NP_792366.1| phosphonates ABC transpor...ter, periplasmic phosphonates-binding protein || http://www.ncbi.nlm.nih.gov/protein/28869747 ...

Sequence Classification: 206174 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH TMB TMB TMB TMB >gi|16124617|ref|NP_419181.1| phosphonates ABC transpor...ter, periplasmic phosphonates-binding protein || http://www.ncbi.nlm.nih.gov/protein/16124617 ...

Sequence Classification: 890155 [

Lifescience Database Archive (English)

Full Text Available esicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance; Pep7p || http://www.ncbi.nlm.nih.gov/protein/6320530 ...

Information for Librarians and Trainers

Science.gov (United States)

... Internet Health Information: A Tutorial from the National Library of Medicine ( download ) Évaluation des sources (NLM): Évaluer les informations sur la santé trouvées sur Internet, in French ( ...

Medline Plus

Full Text Available ... your health knowledge by playing interactive health games. Search all Videos & Tutorials GO GO Understanding Medical Words Tutorial Evaluating Health Information Tutorial To Your Health: NLM Update Podcast About ...

Sequence Classification: 893456 [

Lifescience Database Archive (English)

Full Text Available cles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis; Did4p || http://www.ncbi.nlm.nih.gov/protein/9755336 ...

Sequence Classification: 52354 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH TMB TMB TMB TMB >gi|50083410|ref|YP_044920.1| putative outer membrane usher... protein (probable fimbrial usher protein) || http://www.ncbi.nlm.nih.gov/protein/50083410 ...

Sequence Classification: 500993 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH Non-TMB TMB Non-TMB Non-TMB >gi|66047863|ref|YP_237704.1| Dihydroneopte...rin aldolase family:Dihydroneopterin aldolase || http://www.ncbi.nlm.nih.gov/protein/66047863 ...

Sequence Classification: 654975 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH Non-TMB TMB Non-TMB Non-TMB >gi|72163290|ref|YP_290947.1| dihydroneopte...rin aldolase family:Dihydroneopterin aldolase || http://www.ncbi.nlm.nih.gov/protein/72163290 ...

MetaMap

Data.gov (United States)

U.S. Department of Health & Human Services — MetaMap is a highly configurable application developed by the Lister Hill National Center for Biomedical Communications at the National Library of Medicine (NLM) to...

Sequence Classification: 890096 [

Lifescience Database Archive (English)

Full Text Available ome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination; Din7p || http://www.ncbi.nlm.nih.gov/protein/6320469 ...

Sequence Classification: 889373 [

Lifescience Database Archive (English)

Full Text Available hat stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis; Tsc3p || http://www.ncbi.nlm.nih.gov/protein/14270689 ...

Discover Health Services Near You! The North Dakota Story: Part II

OpenAIRE

Safratowich, Michael; Markland, Mary J.; Rieke, Judith L.

2009-01-01

Since the 2003 launch of NC Health Info, the National Library of Medicine has encouraged the development of Go Local databases. A team of Go Local enthusiasts at North Dakota’s only medical school library wanted to obtain NLM funding and build a resource for their rural state. Although short on staff, money, and time, the team found a way to realize a Go Local database that serves the state’s residents and helps them “Discover Health Services Near You!” A team approach and collaboration with ...

Discover Health Services Near You! The North Dakota Story: Part I

OpenAIRE

Rieke, Judith L.; Safratowich, Michael; Markland, Mary J.

2009-01-01

Since the 2003 launch of NC Health Info, the National Library of Medicine has encouraged the development of Go Local databases. A team of Go Local enthusiasts at North Dakota’s only medical school library wanted to obtain NLM funding and build a resource for their rural state. Although short on staff, money, and time, the team found a way to realize a Go Local database that serves the state’s residents and helps them “Discover Health Services Near You!” A team approach and collaboration with ...

Household Products Database

Science.gov (United States)

... your bathroom, and on the shelves in your laundry room? Learn more about what's in these products, ... MD 20894 National Institutes of Health , Health & Human Services Customer Service: tehip@teh.nlm.nih.gov Last ...

Sequence Classification: 893067 [

Lifescience Database Archive (English)

Full Text Available tuent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm; Nop15p || http://www.ncbi.nlm.nih.gov/protein/6324219 ...

Sequence Classification: 127249 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH TMB Non-TMB TMB Non-TMB >gi|16079493|ref|NP_390317.1| mutants block sporulation... after engulfment (stage III sporulation) || http://www.ncbi.nlm.nih.gov/protein/16079493 ...

Sequence Classification: 567013 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB Non-TMB TMB Non-TMB >gi|15966326|ref|NP_386679.1| PUTATIVE TRANSPORT... SYSTEM PERMEASE ABC TRANSPORTER PROTEIN || http://www.ncbi.nlm.nih.gov/protein/15966326 ...

Sequence Classification: 387954 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH TMB TMB TMB Non-TMB >gi|31792465|ref|NP_854958.1| PROBABLE DRUGS-TRANSPORT... TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER || http://www.ncbi.nlm.nih.gov/protein/31792465 ...

Sequence Classification: 567561 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB TMB TMB Non-TMB >gi|15966874|ref|NP_387227.1| PUTATIVE PEPTIDE TRANSPORT... SYSTEM PERMEASE ABC TRANSPORTER PROTEIN || http://www.ncbi.nlm.nih.gov/protein/15966874 ...

Sequence Classification: 564951 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB TMB TMB Non-TMB >gi|15964264|ref|NP_384617.1| PROBABLE PHOSPHATE TRANSPORT... SYSTEM PERMEASE ABC TRANSPORTER PROTEIN || http://www.ncbi.nlm.nih.gov/protein/15964264 ...

Sequence Classification: 397674 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH TMB TMB TMB Non-TMB >gi|15608413|ref|NP_215789.1| PROBABLE DRUGS-TRANSPORT... TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER || http://www.ncbi.nlm.nih.gov/protein/15608413 ...

Sequence Classification: 480829 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH Non-TMB TMB TMB Non-TMB >gi|26986976|ref|NP_742401.1| taurine ABC transporter, periplasmic tauri...ne-binding protein || http://www.ncbi.nlm.nih.gov/protein/26986976 ...

Sequence Classification: 491135 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH Non-TMB TMB TMB Non-TMB >gi|28872431|ref|NP_795050.1| taurine ABC transporter, periplasmic tauri...ne-binding protein || http://www.ncbi.nlm.nih.gov/protein/28872431 ...

Kidney stones

Science.gov (United States)

... ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 126. Fink HA, Wilt TJ, Eidman KE, et al. Medical ... 23546565 www.ncbi.nlm.nih.gov/pubmed/23546565 . Fink HA, Wilt TJ, Eidman KE, et al. Recurrent ...

Osteoporosis

Science.gov (United States)

... bearing exercises such as walking, jogging, playing tennis, dancing Free weights, weight machines, stretch bands Balance exercises ... 27759931 www.ncbi.nlm.nih.gov/pubmed/27759931 . Black DM, Rosen CJ. Clinical practice: postmenopausal osteoporosis. N ...

Learn to love exercise

Science.gov (United States)

... well, such as tickets to a concert or movie. Alternative Names Prevention - learn to love exercise; Wellness - ... 23630089 www.ncbi.nlm.nih.gov/pubmed/23630089 . Review Date 5/21/2016 Updated by: Linda J. ...

Left heart ventricular angiography

Science.gov (United States)

... blood vessels. These x-ray pictures create a "movie" of the left ventricle as it contracts rhythmically. ... 22578925 www.ncbi.nlm.nih.gov/pubmed/22578925 . Review Date 9/26/2016 Updated by: Michael A. ...

Glossary

Science.gov (United States)

... Huntington disease in the Lake Maracaibo region of Venezuela. Related term: founder variant founder variant A pathogenic ... Support Center External link. Please review our privacy policy . NLM NIH DHHS USA.gov National Center for ...

Sequence Classification: 890578 [

Lifescience Database Archive (English)

Full Text Available ction, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export; Ecm1p || http://www.ncbi.nlm.nih.gov/protein/6319259 ...

Gallbladder removal - laparoscopic - discharge

Science.gov (United States)

... ncbi.nlm.nih.gov/pubmed/26119606 . Jackson PG, Evans SRT. Biliary System. In: Townsend CM Jr, Beauchamp ... A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among ...

Communication with Your Family and Your Doctor about Your Wishes

Science.gov (United States)

... close to the end of your life. References: http://www.aarp.org/families/end_life/ http://www.nlm.nih.gov/medlineplus/endoflifeissues.html http://agnewsarchive.tamu.edu/dailynews/stories/CFAM/Sep0407a.htm ...

Sequence Classification: 893537 [

Lifescience Database Archive (English)

Full Text Available licase in the DEAH-box family involved in the second catalytic step of splicing, exhibits ATP-dependent RNA unwinding activity; Prp16p || http://www.ncbi.nlm.nih.gov/protein/6322939 ...

Granulomatosis with polyangiitis

Science.gov (United States)

... ncbi.nlm.nih.gov/pubmed/21372195 . Specks U, Merkel PA, Seo P, et al. Efficacy of remission- ... PA: Elsevier Saunders; 2016:chap 270. Stone JH, Merkel PA, Spiera R, et al. Rituximab versus cyclophosphamide ...

Sequence Classification: 891376 [

Lifescience Database Archive (English)

Full Text Available l acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, w...hich is important in brewing; Atf2p || http://www.ncbi.nlm.nih.gov/protein/6321616 ...

The MedlinePlus public user interface: studies of design challenges and opportunities

Science.gov (United States)

Marill, Jennifer L.; Miller, Naomi; Kitendaugh, Paula

2006-01-01

Question: What are the challenges involved in designing, modifying, and improving a major health information portal that serves over sixty million page views a month? Setting: MedlinePlus, the National Library of Medicine's (NLM's) consumer health Website, is examined. Method: Challenges are presented as six “studies,” which describe selected design issues and how NLM staff resolved them. Main Result: Improving MedlinePlus is an iterative process. Changes in the public user interface are ongoing, reflecting Web design trends, usability testing recommendations, user survey results, new technical requirements, and the need to grow the site in an orderly way. Conclusion: Testing and analysis should accompany Website design modifications. New technologies may enhance a site but also introduce problems. Further modifications to MedlinePlus will be informed by the experiences described here. PMID:16404467

Concussion

Science.gov (United States)

... www.ncbi.nlm.nih.gov/pubmed/ 23522509 . Krach LE. Severe traumatic brain injury. In: Kliegman RM, Stanton ... Walls RM, Hockberger RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice . 9th ed. ...

Sequence Classification: 103815 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|52144563|ref|YP_082265.1| disulfide bond... formation protein (disulfide bond oxidoreductase) || http://www.ncbi.nlm.nih.gov/protein/52144563 ...

Sequence Classification: 132534 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|49480300|ref|YP_035017.1| disulfide bond... formation protein (disulfide bond oxidoreductase) || http://www.ncbi.nlm.nih.gov/protein/49480300 ...

Sequence Classification: 428713 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|17230369|ref|NP_486917.1| bicarbonate transport bicarbon...ate-binding protein || http://www.ncbi.nlm.nih.gov/protein/17230369 ...

Dream Robber: Living with Parkinson's disease

Science.gov (United States)

... Current Issue Past Issues Dream Robber: Living with Parkinson's disease Past Issues / Summer 2006 Table of Contents ... effects of levodopa called dyskinesias. Additional Information on Parkinson's Web Links MedlinePlus: http://www.nlm.nih.gov/ ...

Sequence Classification: 890604 [

Lifescience Database Archive (English)

Full Text Available scriptional coactivator SKIP, can activate transcription of a reporter gene; interacts with splicing factors Prp22p and Prp46p; Prp45p || http://www.ncbi.nlm.nih.gov/protein/6319287 ...

Sequence Classification: 127254 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB TMB Non-TMB Non-TMB >gi|16079498|ref|NP_390322.1| mutants block sporulation... after engulfment (stage III sporulation) || http://www.ncbi.nlm.nih.gov/protein/16079498 ...

Sequence Classification: 891809 [

Lifescience Database Archive (English)

Full Text Available unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic int...eractions with other genes required for sporulation; Spr6p || http://www.ncbi.nlm.nih.gov/protein/6320961 ...

Sequence Classification: 127252 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB Non-TMB TMB Non-TMB >gi|16079496|ref|NP_390320.1| mutants block sporulation... after engulfment (stage III sporulation) || http://www.ncbi.nlm.nih.gov/protein/16079496 ...

Sequence Classification: 759628 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH TMB TMB TMB TMB >gi|15221381|ref|NP_177004.1| gravity-responsive protei...n / altered response to gravity protein (ARG1) || http://www.ncbi.nlm.nih.gov/protein/15221381 ...

Steroid Treatments Equally Effective Against Sudden Deafness

Science.gov (United States)

... NIGMS NIMH NIMHD NINDS NINR NLM CC CIT CSR FIC NCATS NCCIH OD About NIH Who We ... with sudden deafness should discuss the risks and benefits of both treatments with their doctor.” Related Links ...

Hormone Treatment Restores Bone Density for Young Women with Menopause-Like Condition (Primary Ovarian Insufficiency)

Science.gov (United States)

... NIGMS NIMH NIMHD NINDS NINR NLM CC CIT CSR FIC NCATS NCCIH OD About NIH Who We ... valid results as to whether testosterone replacement could benefit women with POI, Dr. Nelson said. “While hormone ...

Sequence Classification: 611166 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB Non-TMB TMB Non-TMB >gi|21911225|ref|NP_665493.1| putative determinant for enhanced expr...ession of pheromone || http://www.ncbi.nlm.nih.gov/protein/21911225 ...

Sequence Classification: 890555 [

Lifescience Database Archive (English)

Full Text Available synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and... induced by allophanate, an intermediate in allantoin degradation; Dal7p || http://www.ncbi.nlm.nih.gov/protein/6322222 ...

Sequence Classification: 567406 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|15966719|ref|NP_387072.1| PUTATIVE TRANSPORT... SYSTEM PERMEASE ABC TRANSPORTER PROTEIN || http://www.ncbi.nlm.nih.gov/protein/15966719 ...

Sequence Classification: 567688 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB TMB TMB Non-TMB >gi|15967001|ref|NP_387354.1| PUTATIVE AMINO-ACID TRANSPORT... SYSTEM PERMEASE ABC TRANSPORTER PROTEIN || http://www.ncbi.nlm.nih.gov/protein/15967001 ...

Sequence Classification: 397326 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB TMB TMB Non-TMB >gi|57116799|ref|NP_215445.2| PROBABLE PHOSPHATE-TRANSPORT... INTEGRAL MEMBRANE ABC TRANSPORTER PSTA1 || http://www.ncbi.nlm.nih.gov/protein/57116799 ...

Sequence Classification: 566953 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB TMB Non-TMB Non-TMB >gi|15966266|ref|NP_386619.1| PUTATIVE SUGAR TRANSPORT... SYSTEM PERMEASE ABC TRANSPORTER PROTEIN || http://www.ncbi.nlm.nih.gov/protein/15966266 ...

Sequence Classification: 398736 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB TMB TMB Non-TMB >gi|15609453|ref|NP_216832.1| PROBABLE SUGAR-TRANSPORT... INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER USPA || http://www.ncbi.nlm.nih.gov/protein/15609453 ...

Sequence Classification: 396453 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH Non-TMB TMB Non-TMB Non-TMB >gi|15607215|ref|NP_214587.1| PROBABLE GLUTAMINE-TRANSPORT... ATP-BINDING PROTEIN ABC TRANSPORTER || http://www.ncbi.nlm.nih.gov/protein/15607215 ...

Sequence Classification: 893726 [

Lifescience Database Archive (English)

Full Text Available se, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disru...ption enhances freeze tolerance; Car1p || http://www.ncbi.nlm.nih.gov/protein/6325146 ...

Sequence Classification: 892485 [

Lifescience Database Archive (English)

Full Text Available d ensuring genomic integrity; multisite phosphorylation by Cdc28-Cln kinase targets Sic1p for SCF(CDC4)-dependent turnover; Sic1p || http://www.ncbi.nlm.nih.gov/protein/6323108 ...

Sequence Classification: 290085 [

Lifescience Database Archive (English)

Full Text Available ropteridine reductase, ferrisiderophore reductase activity || http://www.ncbi.nlm.nih.gov/protein/16130477 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|16130477|ref|NP_417047.1| dihyd

Sequence Classification: 558868 [

Lifescience Database Archive (English)

Full Text Available ropteridine reductase, ferrisiderophore reductase activity || http://www.ncbi.nlm.nih.gov/protein/74313075 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|74313075|ref|YP_311494.1| dihyd

Sequence Classification: 295249 [

Lifescience Database Archive (English)

Full Text Available ropteridine reductase, ferrisiderophore reductase activity || http://www.ncbi.nlm.nih.gov/protein/15803077 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|15803077|ref|NP_289108.1| dihyd

Stemcell Information: SKIP000887 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available NICATIONS 2015 7 11471 ... http://www.ncbi.nlm.nih.gov/pubmed/27161380 ... ...Tumour resistance in induced pluripotent stem cells derived from naked mole-rats. Shingo Miyawaki, Hideyuki Okano et al. NATURE COMMU

Sequence Classification: 492292 [

Lifescience Database Archive (English)

Full Text Available ansporter, periplasmic energy transduction protein TonB || http://www.ncbi.nlm.nih.gov/protein/71735471 ... ...TMB TMH Non-TMB TMB TMB Non-TMB >gi|71735471|ref|YP_273188.1| ferric siderophore tr

Sequence Classification: 474584 [

Lifescience Database Archive (English)

Full Text Available ansporter, periplasmic energy transduction protein TonB || http://www.ncbi.nlm.nih.gov/protein/70728373 ... ...TMB TMH Non-TMB TMB TMB Non-TMB >gi|70728373|ref|YP_258122.1| ferric siderophore tr

Visible Human Project

Science.gov (United States)

... cryosections are associated with anatomical terminology. AnatLine : A prototype system consisting of an anatomical image database and ... further information is available Publications VHJOE: Visible Human Journal of Endoscopy. NLM's Current Bibliographies in Medicine, Visible ...

Sequence Classification: 889686 [

Lifescience Database Archive (English)

Full Text Available ivities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; Sfa1p || http://www.ncbi.nlm.nih.gov/protein/6320033 ...

Sequence Classification: 894222 [

Lifescience Database Archive (English)

Full Text Available the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases; Ckb2p || http://www.ncbi.nlm.nih.gov/protein/6324613 ...

Pressure Points: Preventing and Controlling Hypertension

Science.gov (United States)

... Issue Past Issues Pressure Points: Preventing and Controlling Hypertension Past Issues / Summer 2006 Table of Contents For ... diagnosed with high blood pressure." Aditional Information On Hypertension MedlinePlus: High blood pressure: http://www.nlm.nih. ...

Sequence Classification: 512897 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|17548159|ref|NP_521561.1| PROBABLE CHROMOSOMAL REPLICATI...ON INITIATOR PROTEIN DNAA || http://www.ncbi.nlm.nih.gov/protein/17548159 ...

Sequence Classification: 889932 [

Lifescience Database Archive (English)

Full Text Available ctor, involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1; Gis1p || http://www.ncbi.nlm.nih.gov/protein/6320301 ...

Sequence Classification: 891556 [

Lifescience Database Archive (English)

Full Text Available nvolved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles; Loc1p || http://www.ncbi.nlm.nih.gov/protein/14318523 ...

Sequence Classification: 127251 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|16079495|ref|NP_390319.1| mutants block sporulation... after engulfment (stage III sporulation) || http://www.ncbi.nlm.nih.gov/protein/16079495 ...

Sequence Classification: 127253 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|16079497|ref|NP_390321.1| mutants block sporulation... after engulfment (stage III sporulation) || http://www.ncbi.nlm.nih.gov/protein/16079497 ...

Sequence Classification: 127250 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|16079494|ref|NP_390318.1| mutants block sporulation... after engulfment (stage III sporulation) || http://www.ncbi.nlm.nih.gov/protein/16079494 ...

Sequence Classification: 439557 [

Lifescience Database Archive (English)

Full Text Available cal stbA Plasmid stable inheritance protein || http://www.ncbi.nlm.nih.gov/protein/54307287 ... ...Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|54307287|ref|YP_128307.1| Hypotheti

Complete nucleotide sequence and gene rearrangement of the ...

Indian Academy of Sciences (India)

3Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China ... of these rearrangements involve tRNA genes, ND5 gene and ... ncbi.nlm.nih.gov/projects/Sequin/download/seq_win_download.

Sequence Classification: 468053 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|50842952|ref|YP_056179.1| riboflavin... biosynthesis protein RibF (riboflavin kinase) || http://www.ncbi.nlm.nih.gov/protein/50842952 ...

Taking narcotics for back pain

Science.gov (United States)

... ncbi.nlm.nih.gov/pubmed/24480962 . Dinakar P. Principles of pain management. In: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, eds. Bradley's Neurology in Clinical Practice . 7th ed. Philadelphia, PA: Elsevier; 2016:chap 54. ...

Sequence Classification: 203907 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|71891851|ref|YP_277580.1| dihydrone...opterin aldolase, also has dihydroneopterin triphosphate || http://www.ncbi.nlm.nih.gov/protein/71891851 ...

Sequence Classification: 399366 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB TMB TMB Non-TMB >gi|15610075|ref|NP_217454.1| PROBABLE DAUNORUBICIN-DIM-TRANSPORT... INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER DRRC || http://www.ncbi.nlm.nih.gov/protein/15610075 ...

Sequence Classification: 182166 [

Lifescience Database Archive (English)

Full Text Available TMB TMH Non-TMB TMB Non-TMB Non-TMB >gi|17986643|ref|NP_539277.1| ABC TRANSPORTER A...TP-BINDING PROTEIN / ABC TRANSPORTER PERMEASE PROTEIN || http://www.ncbi.nlm.nih.gov/protein/17986643 ...

Sequence Classification: 397382 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB TMB TMB >gi|15608126|ref|NP_215501.1| PROBABLE ADHESION COMPONENT TRANSPORT... ATP-BINDING PROTEIN ABC TRANSPORTER || http://www.ncbi.nlm.nih.gov/protein/15608126 ...

Sequence Classification: 397331 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|57116802|ref|YP_177771.1| PHOSPHATE-TRANSPORT... INTEGRAL MEMBRANE ABC TRANSPORTER PSTC1 || http://www.ncbi.nlm.nih.gov/protein/57116802 ...

Sequence Classification: 389604 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB TMB TMB Non-TMB >gi|31794115|ref|NP_856608.1| PROBABLE DAUNORUBICIN-DIM-TRANSPORT... INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER DRRC || http://www.ncbi.nlm.nih.gov/protein/31794115 ...

Sequence Classification: 565916 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB TMB TMB Non-TMB >gi|15965229|ref|NP_385582.1| PROBABLE GENERAL L-AMINO ACID TRANSPORT... PERMEASE ABC TRANSPORTER PROTEIN || http://www.ncbi.nlm.nih.gov/protein/15965229 ...

Sequence Classification: 389501 [

Lifescience Database Archive (English)

Full Text Available TMB TMH TMB TMB TMB Non-TMB >gi|31794012|ref|NP_856505.1| PROBABLE Sn-GLYCEROL-3-PHOSPHATE TRANSPORT... INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER UGPAA || http://www.ncbi.nlm.nih.gov/protein/31794012 ...

Sequence Classification: 389235 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH Non-TMB TMB Non-TMB Non-TMB >gi|31793746|ref|NP_856239.1| PROBABLE GLUTAMINE-TRANSPORT... ATP-BINDING PROTEIN ABC TRANSPORTER GLNQ || http://www.ncbi.nlm.nih.gov/protein/31793746 ...

Medical Movies on the Web Debuts with Gene Kelly's "Combat Fatigue Irritability" 1945 Film | NIH MedlinePlus the ...

Science.gov (United States)

... National Library of Medicine (NLM) is a World War II U.S. Navy training film directed by and starring Gene Kelly, who was then a rising Hollywood star. Combat Fatigue Irritability is a historically significant, yet ...

Genetics Home Reference: action myoclonus-renal failure syndrome

Science.gov (United States)

... can be triggered by voluntary movements or the intention to move (action myoclonus). These myoclonic jerks typically ... Available from http://www.ncbi.nlm.nih.gov/books/NBK333437/ Citation on PubMed Balreira A, Gaspar P, ...

Genetics Home Reference: Pelizaeus-Merzbacher-like disease type 1

Science.gov (United States)

... scale (dysmetria), tremors that occur mainly during movement (intention tremors), and head and neck tremors (titubation). People ... Available from http://www.ncbi.nlm.nih.gov/books/NBK470716/ Citation on PubMed Orthmann-Murphy JL, Freidin ...

Magic Meets Medicine at NIH | NIH MedlinePlus the Magazine

Science.gov (United States)

... come up with the idea to feature the Harry Potter exhibit at NLM? In 2007, our colleague Stephen ... fueled the idea for an exhibition. As any Harry Potter fan will know, Nicolas Flamel is referenced several ...

Sequence Classification: 889445 [

Lifescience Database Archive (English)

Full Text Available sl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; Hsl7p || http://www.ncbi.nlm.nih.gov/protein/6319610 ...

Sequence Classification: 893175 [

Lifescience Database Archive (English)

Full Text Available rase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex; Rpc34p || http://www.ncbi.nlm.nih.gov/protein/6324330 ...

Sequence Classification: 561281 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB TMB Non-TMB >gi|56695579|ref|YP_165929.1| taurine A...BC transporter, periplasmic taurine-binding protein || http://www.ncbi.nlm.nih.gov/protein/56695579 ...

Sequence Classification: 188260 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|23500899|ref|NP_700339.1| taurine ABC transporter, tauri...ne-binding protein || http://www.ncbi.nlm.nih.gov/protein/23500899 ...

Sequence Classification: 193264 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|53716248|ref|YP_106165.1| taurine... ABC transporter, periplasmic taurine-binding protein || http://www.ncbi.nlm.nih.gov/protein/53716248 ...

Sequence Classification: 181792 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|62318001|ref|YP_223854.1| taurine ABC transporter, tauri...ne-binding protein || http://www.ncbi.nlm.nih.gov/protein/62318001 ...

ApoE (Apolipoprotein E) Genotyping

Science.gov (United States)

... nlm.nih.gov/medlineplus/ency/article/000392.htm . Stephen P. Day, Ph.D. Director, Medical Affairs, Third Wave Molecular Diagnostics. Robert C. Green, M.D., M.P.H. Professor of Neurology, Genetics and Epidemiology. Director, Alzheimer's ...

Sequence Classification: 405020 [

Lifescience Database Archive (English)

Full Text Available hoglycerate mutase (2,3-diphosphoglycerate-independent) || http://www.ncbi.nlm.nih.gov/protein/42561347 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|42561347|ref|NP_975798.1| phosp

MedlinePlus Connect: How it Works

Science.gov (United States)

... Connect → How it Works URL of this page: https://medlineplus.gov/connect/howitworks.html MedlinePlus Connect: How ... will change.) Old URLs New URLs Web Application https://apps.nlm.nih.gov/medlineplus/services/mpconnect.cfm? ...

MedlinePlus Connect in Use

Science.gov (United States)

... MedlinePlus Connect in Use URL of this page: https://medlineplus.gov/connect/users.html MedlinePlus Connect in ... will change.) Old URLs New URLs Web Application https://apps.nlm.nih.gov/medlineplus/services/mpconnect.cfm? ...

NIH Research Leads to Cervical Cancer Vaccine

Science.gov (United States)

... Issues Sexually Transmitted Diseases NIH Research Leads to Cervical Cancer Vaccine Past Issues / Fall 2008 Table of Contents ... in women, the cause of the majority of cervical cancers. Photo courtesy of Judy Folkenberg, NLM Writer By ...

Sequence Classification: 776671 [

Lifescience Database Archive (English)

Full Text Available ar zinc finger protein, Mog interacting, Ectopic P granules MEP-1, GEX (Gut on EXterior) Interacting protein GEI-2 (97.4 kD) (mep-1) || http://www.ncbi.nlm.nih.gov/protein/25152712 ...

Sequence Classification: 204232 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH TMB TMB Non-TMB Non-TMB >gi|71892173|ref|YP_277905.1| transport protein of outer membrane lipopr...oteins (ABC superfamily, membrane) || http://www.ncbi.nlm.nih.gov/protein/71892173 ...

Sequence Classification: 288695 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB TMB TMB Non-TMB >gi|16129079|ref|NP_415634.1| transport protein of outer membrane lipopr...oteins (ABC superfamily, membrane) || http://www.ncbi.nlm.nih.gov/protein/16129079 ...

Sequence Classification: 751792 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH Non-TMB TMB Non-TMB TMB >gi|30686748|ref|NP_849438.1| magnesium-protopo...rphyrin O-methyltransferase, putative / magnesium-protoporphyrin IX methyltransferase, putative || http://www.ncbi.nlm.nih.gov/protein/30686748 ...

Sequence Classification: 751793 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH Non-TMB TMB Non-TMB TMB >gi|30686750|ref|NP_849439.1| magnesium-protopo...rphyrin O-methyltransferase, putative / magnesium-protoporphyrin IX methyltransferase, putative || http://www.ncbi.nlm.nih.gov/protein/30686750 ...

Sequence Classification: 751791 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH Non-TMB TMB Non-TMB TMB >gi|15234905|ref|NP_194238.1| magnesium-protopo...rphyrin O-methyltransferase, putative / magnesium-protoporphyrin IX methyltransferase, putative || http://www.ncbi.nlm.nih.gov/protein/15234905 ...

Sequence Classification: 782806 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB TMB Non-TMB >gi|17563554|ref|NP_505093.1| predicted... CDS, immunodominant hypodermal antigen-related (5I579) || http://www.ncbi.nlm.nih.gov/protein/17563554 ...

Sequence Classification: 76862 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|47777819|ref|YP_022534.1| prophage lambdaba04, dna packa...ging protein, putative || http://www.ncbi.nlm.nih.gov/protein/47777819 ...

Sequence Classification: 308706 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|56421142|ref|YP_148460.1| stage 0 sporulation... protein B (sporulation initiation phosphoprotein) || http://www.ncbi.nlm.nih.gov/protein/56421142 ...

Sequence Classification: 127255 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|16079499|ref|NP_390323.1| mutants block sporulation... after engulfment (stage III sporulation) || http://www.ncbi.nlm.nih.gov/protein/16079499 ...

Sequence Classification: 109986 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|56963465|ref|YP_175196.1| stage II sporulation... protein J, sporulation kinase A || http://www.ncbi.nlm.nih.gov/protein/56963465 ...

Sequence Classification: 844471 [

Lifescience Database Archive (English)

Full Text Available ive NUCLEOLAR PROTEIN (TRANSFORMER 2-LIKE PROTEIN) || http://www.ncbi.nlm.nih.gov/protein/19074273 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|19074273|ref|NP_585779.1| putat

Sequence Classification: 732582 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH TMB Non-TMB Non-TMB Non-TMB >gi|45443438|ref|NP_994977.1| riboflavin... biosynthesis protein (includes: riboflavin kinase and FMN adenyltransferase) || http://www.ncbi.nlm.nih.gov/protein/45443438 ...

Sequence Classification: 721488 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH TMB Non-TMB Non-TMB Non-TMB >gi|16120803|ref|NP_404116.1| riboflavin... biosynthesis protein (includes: riboflavin kinase and FMN adenyltransferase) || http://www.ncbi.nlm.nih.gov/protein/16120803 ...

Sequence Classification: 145345 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|29347953|ref|NP_811456.1| riboflavin... biosynthesis protein ribF, putative riboflavin kinase || http://www.ncbi.nlm.nih.gov/protein/29347953 ...

Sequence Classification: 184807 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|17989285|ref|NP_541918.1| MALTO...SE/MALTODEXTRIN TRANSPORT ATP-BINDING PROTEIN MALK || http://www.ncbi.nlm.nih.gov/protein/17989285 ...

Sequence Classification: 184808 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|17989286|ref|NP_541919.1| MALTO...SE/MALTODEXTRIN TRANSPORT ATP-BINDING PROTEIN MALK || http://www.ncbi.nlm.nih.gov/protein/17989286 ...

Sequence Classification: 565174 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|15964487|ref|NP_384840.1| PROBABLE DIPEPTIDE TRANSPORT... ATP-BINDING ABC TRANSPORTER PROTEIN || http://www.ncbi.nlm.nih.gov/protein/15964487 ...

Sequence Classification: 389349 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|31793860|ref|NP_856353.1| PROBABLE ANTIBIOTIC-TRANSPORT... ATP-BINDING PROTEIN ABC TRANSPORTER || http://www.ncbi.nlm.nih.gov/protein/31793860 ...

Sequence Classification: 397216 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB TMB >gi|15607960|ref|NP_215335.1| PROBABLE PHOSPHATE-TRANSPORT... ATP-BINDING PROTEIN ABC TRANSPORTER PHOT || http://www.ncbi.nlm.nih.gov/protein/15607960 ...

Sequence Classification: 396576 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|15607335|ref|NP_214708.1| PROBABLE DRUGS-TRANSPORT... TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER || http://www.ncbi.nlm.nih.gov/protein/15607335 ...

Sequence Classification: 565019 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|15964332|ref|NP_384685.1| PROBABLE PYRAZINAMIDAS...E/NICOTINAMIDASE (INCLUDES: PYRAZINAMIDASE, NICOTINAMIDASE) PROTEIN || http://www.ncbi.nlm.nih.gov/protein/15964332 ...

Sequence Classification: 525310 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH Non-TMB TMB Non-TMB Non-TMB >gi|62181723|ref|YP_218140.1| dihydroneopte...rin aldolase, also has dihydroneopterin triphosphate 2'-epimerase activity || http://www.ncbi.nlm.nih.gov/protein/62181723 ...

Sequence Classification: 290568 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH Non-TMB TMB Non-TMB Non-TMB >gi|16130954|ref|NP_417530.1| dihydroneopte...rin aldolase, also has dihydroneopterin triphosphate 2'-epimerase activity || http://www.ncbi.nlm.nih.gov/protein/16130954 ...

Translational selection in human: More pronounced in housekeeping genes

KAUST Repository

Ma, Lina; Cui, Peng; Zhu, Jiang; Zhang, Zhihua; Zhang, Zhang

2014-01-01

by Yuan Yuan, Baylor College of Medicine; Han Liang, University of Texas MD Anderson Cancer Center (nominated by Dr Laura Landweber) Eugene Koonin, NCBI, NLM, NIH, United States of America Sandor Pongor, International Centre for Genetic Engineering

Talking to Your Doctor

Medline Plus

Full Text Available ... NINR NLM CC CIT CSR FIC NCATS NCCIH OD About NIH Who We Are What We Do ... Information For more information about this publication, contact OD OCPL Inquiries . This page last reviewed on November ...

Sequence Classification: 757776 [

Lifescience Database Archive (English)

Full Text Available ulinase family protein || http://www.ncbi.nlm.nih.gov/protein/22330137 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB TMB >gi|22330137|ref|NP_175386.2| peptidase M16 family protein / ins

Sequence Classification: 757775 [

Lifescience Database Archive (English)

Full Text Available ulinase family protein || http://www.ncbi.nlm.nih.gov/protein/30694608 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB TMB >gi|30694608|ref|NP_850962.1| peptidase M16 family protein / ins

Sequence Classification: 740923 [

Lifescience Database Archive (English)

Full Text Available ulinase family protein || http://www.ncbi.nlm.nih.gov/protein/22331173 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB TMB >gi|22331173|ref|NP_188548.2| peptidase M16 family protein / ins

Sequence Classification: 757774 [

Lifescience Database Archive (English)

Full Text Available ulinase family protein || http://www.ncbi.nlm.nih.gov/protein/30694606 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB TMB >gi|30694606|ref|NP_850961.1| peptidase M16 family protein / ins

Sequence Classification: 516215 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|39936399|ref|NP_948675.1| possible lipopeptide antibioti...cs iturin a biosynthesis protein || http://www.ncbi.nlm.nih.gov/protein/39936399 ...

MedlinePlus Connect: Web Service

Science.gov (United States)

... MedlinePlus Connect → Web Service URL of this page: https://medlineplus.gov/connect/service.html MedlinePlus Connect: Web ... will change.) Old URLs New URLs Web Application https://apps.nlm.nih.gov/medlineplus/services/mpconnect.cfm? ...

MedlinePlus Connect: Web Application

Science.gov (United States)

... MedlinePlus Connect → Web Application URL of this page: https://medlineplus.gov/connect/application.html MedlinePlus Connect: Web ... will change.) Old URLs New URLs Web Application https://apps.nlm.nih.gov/medlineplus/services/mpconnect.cfm? ...

MedlinePlus Connect: Technical Information

Science.gov (United States)

... MedlinePlus Connect → Technical Information URL of this page: https://medlineplus.gov/connect/technical.html MedlinePlus Connect: Technical ... will change.) Old URLs New URLs Web Application https://apps.nlm.nih.gov/medlineplus/services/mpconnect.cfm? ...

MedlinePlus Connect: Linking Patient Portals and Electronic Health Records to Health Information

Science.gov (United States)

... Here: Home → MedlinePlus Connect URL of this page: https://medlineplus.gov/connect/overview.html MedlinePlus Connect Linking ... will change.) Old URLs New URLs Web Application https://apps.nlm.nih.gov/medlineplus/services/mpconnect.cfm? ...

MedlinePlus Connect: Email List

Science.gov (United States)

... MedlinePlus Connect → Email List URL of this page: https://medlineplus.gov/connect/emaillist.html MedlinePlus Connect: Email ... will change.) Old URLs New URLs Web Application https://apps.nlm.nih.gov/medlineplus/services/mpconnect.cfm? ...

Sequence Classification: 778807 [

Lifescience Database Archive (English)

Full Text Available shifting from yeast to mammals (9.3 kD) (1G671) || http://www.ncbi.nlm.nih.gov/protein/17511075 ... ...hine decarboxylase antizyme, involved in polyamine regulation and subject to a conserved translational frame

Sequence Classification: 557242 [

Lifescience Database Archive (English)

Full Text Available ffects translocation of lipoproteins from inner membrane to outer || http://www.ncbi.nlm.nih.gov/protein/74311449 ... ...TMB Non-TMH TMB TMB TMB Non-TMB >gi|74311449|ref|YP_309868.1| periplasmic protein e

Sequence Classification: 54655 [

Lifescience Database Archive (English)

Full Text Available tein of outer membrane lipoproteins (ABC superfamily, membrane) || http://www.ncbi.nlm.nih.gov/protein/50085711 ... ...Non-TMB TMH Non-TMB TMB Non-TMB Non-TMB >gi|50085711|ref|YP_047221.1| transport pro

Sequence Classification: 292926 [

Lifescience Database Archive (English)

Full Text Available ffects translocation of lipoproteins from inner membrane to outer || http://www.ncbi.nlm.nih.gov/protein/15800754 ... ...TMB Non-TMH TMB TMB TMB Non-TMB >gi|15800754|ref|NP_286768.1| periplasmic protein e

Sequence Classification: 523072 [

Lifescience Database Archive (English)

Full Text Available roteins from inner membrane to outer membrane || http://www.ncbi.nlm.nih.gov/protein/62179485 ... ...TMB TMH TMB TMB TMB Non-TMB >gi|62179485|ref|YP_215902.1| periplasmic protein effects translocation of lipop

Sequence Classification: 54654 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH Non-TMB TMB TMB Non-TMB >gi|50085710|ref|YP_047220.1| transport protein of outer membrane lipopr...oteins (ABC superfamily, atp_bind) || http://www.ncbi.nlm.nih.gov/protein/50085710 ...

Stemcell Information: SKIP000385 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available Teratoma formation ... Yes ... Yes ... National Research Institute for Child Health and Development htt...p://www.ncbi.nlm.nih.gov/geo/ Akihiro Umezawa 梅澤　明弘 Available National Research Institute for Child Health a

Sequence Classification: 87482 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|49183476|ref|YP_026728.1| prophage LambdaBa04, DNA packa...ging protein, putative || http://www.ncbi.nlm.nih.gov/protein/49183476 ...

Sequence Classification: 82171 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|30260632|ref|NP_843009.1| prophage LambdaBa04, DNA packa...ging protein, putative || http://www.ncbi.nlm.nih.gov/protein/30260632 ...

Sequence Classification: 515497 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB TMB Non-TMB Non-TMB >gi|39935681|ref|NP_947957.1| putative nitrogen...ase iron protein (nitrogenase component II) (nitrogenase reductase) || http://www.ncbi.nlm.nih.gov/protein/39935681 ...

Sequence Classification: 514329 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|39934512|ref|NP_946788.1| nitrogenase iron protein (nitr...ogenase component II) (nitrogenase reductase) || http://www.ncbi.nlm.nih.gov/protein/39934512 ...

Learning about Duchenne Muscular Dystrophy

Science.gov (United States)

... protein. Often these boys are classified as having Becker muscular dystrophy. Genetic testing (looking at the body's genetic instructions) ... National Library of Medicine Web site Duchenne and Becker muscular dystrophy [ghr.nlm.nih.gov] From Genetics Home Reference ...

Sequence Classification: 389499 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB TMB TMB Non-TMB >gi|31794010|ref|NP_856503.1| PROBABLE Sn-GLYCEROL-3-PHOSPHATE TRANSPORT... INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER UGPE || http://www.ncbi.nlm.nih.gov/protein/31794010 ...

Sequence Classification: 155582 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|33519541|ref|NP_878373.1| dihydrone...opterin aldolase, also has dihydroneopterin triphosphate 2'-epimerase activity || http://www.ncbi.nlm.nih.gov/protein/33519541 ...

Researcher Story: Stuttering

Medline Plus

Full Text Available ... NIDA NIEHS NIGMS NIMH NIMHD NINDS NINR NLM CC CIT CSR FIC NCATS NCCIH OD About NIH ... Public Liaison Office, (800) 411-1222, prpl@mail.cc.nih.gov . The King’s Speech: George VI Video ...

Sequence Classification: 378135 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH TMB Non-TMB Non-TMB Non-TMB >gi|13475854|ref|NP_107424.1| agaE protein, conversion of agropini...c acid to mannopinic acid || http://www.ncbi.nlm.nih.gov/protein/13475854 ...

Tracking Color Shift in Ballpoint Pen Ink Using Photoshop Assisted Spectroscopy: A Nondestructive Technique Developed to Rehouse a Nobel Laureate's Manuscript.

Science.gov (United States)

Wright, Kristi; Herro, Holly

2016-01-01

Many historically and culturally significant documents from the mid-to-late twentieth century were written in ballpoint pen inks, which contain light-sensitive dyes that present problems for collection custodians and paper conservators. The conservation staff at the National Library of Medicine (NLM), National Institutes of Health, conducted a multiphase project on the chemistry and aging of ballpoint pen ink that culminated in the development of a new method to detect aging of ballpoint pen ink while examining a variety of storage environments. NLM staff determined that ballpoint pen ink color shift can be detected noninvasively using image editing software. Instructions are provided on how to detect color shift in digitized materials using a technique developed specifically for this project-Photoshop Assisted Spectroscopy. 1 The study results offer collection custodians storage options for historic documents containing ballpoint pen ink.

Sequence Classification: 543110 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|16767113|ref|NP_462728.1| 2-oxo-3-deoxygalactona...te 6-phosphate aldolase/galactonate dehydratase || http://www.ncbi.nlm.nih.gov/protein/16767113 ...

Sequence Classification: 131329 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|49479095|ref|YP_037967.1| sporulation... sigma-E factor processing peptidase (stage II sporulation protein GA) || http://www.ncbi.nlm.nih.gov/protein/49479095 ...

Sequence Classification: 891219 [

Lifescience Database Archive (English)

Full Text Available aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathwa...ys; required for normal oxidative stress tolerance and nitrogen utilization; Uga1p || http://www.ncbi.nlm.nih.gov/protein/6321456 ...

Sequence Classification: 894699 [

Lifescience Database Archive (English)

Full Text Available ISW2/yCHRAC chromatin accessibility complex along with Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; Dls1p || http://www.ncbi.nlm.nih.gov/protein/6322397 ...

Sequence Classification: 408910 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|59800954|ref|YP_207666.1| putative plasmid stable inheri...tance protein putative phage associated protein || http://www.ncbi.nlm.nih.gov/protein/59800954 ...

Sequence Classification: 258180 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|71909593|ref|YP_287180.1| HupH hydrogenase express...ion protein, C-terminal conserved region || http://www.ncbi.nlm.nih.gov/protein/71909593 ...

Viewers & Players

Science.gov (United States)

... mov Apple iTunes Download NLM podcasts and applications. mp3 mp4 mov Adobe Reader Read and print Portable ... video and audio files on PC operating systems. mp3 wav wmz About MedlinePlus Site Map FAQs Customer ...

Morning sickness

Science.gov (United States)

... for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev . 2015;(9):CD007575. PMID: 26348534 www.ncbi.nlm.nih.gov/pubmed/26348534 . West EH, Hark L, Catalano PM. Nutrition during pregnancy. In: Gabbe SG, Niebyl JR, Simpson ...

Sequence Classification: 378211 [

Lifescience Database Archive (English)

Full Text Available nic acid to mannopinic acid || http://www.ncbi.nlm.nih.gov/protein/13475930 ... ...Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|13475930|ref|NP_107500.1| AgaE protein, conversion of agropi

Sequence Classification: 521337 [

Lifescience Database Archive (English)

Full Text Available TMB TMH Non-TMB TMB Non-TMB Non-TMB >gi|51473233|ref|YP_066990.1| Bacterial leader ...peptidase I.; Phage-procoat-leader peptidase.; SPase I.; signal peptidase I || http://www.ncbi.nlm.nih.gov/protein/51473233 ...

Sequence Classification: 227637 [

Lifescience Database Archive (English)

Full Text Available biotics resistance protein, NimA-family || http://www.ncbi.nlm.nih.gov/protein/15895740 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|15895740|ref|NP_349089.1| Possible 5-Nitroimidazole anti

Articles about MedlinePlus

Science.gov (United States)

... MedlinePlus → Articles about MedlinePlus URL of this page: https://medlineplus.gov/bibliography.html Articles about MedlinePlus To ... Dec 29]; 3(5):256-60. Available from: http://ecp.acponline.org/sepoct00/nlm.htm . Marill JL, ...

Sequence Classification: 890345 [

Lifescience Database Archive (English)

Full Text Available n involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1; Rba50p || http://www.ncbi.nlm.nih.gov/protein/6320735 ...

Sequence Classification: 291861 [

Lifescience Database Archive (English)

Full Text Available red for the efficient incorporation of molybdate into molybdoproteins || http://www.ncbi.nlm.nih.gov/protein/15799689 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|15799689|ref|NP_285701.1| requi

Sequence Classification: 556416 [

Lifescience Database Archive (English)

Full Text Available red for the efficient incorporation of molybdate into molybdoproteins || http://www.ncbi.nlm.nih.gov/protein/74310623 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|74310623|ref|YP_309042.1| requi

Sequence Classification: 894067 [

Lifescience Database Archive (English)

Full Text Available involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chrom...ium accumulation, and response to osmotic stress; localizes to the nucleus; Msn1p || http://www.ncbi.nlm.nih.gov/protein/6324456 ...

Sequence Classification: 378184 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|13475903|ref|NP_107473.1| 2-oxo-3-deoxygalactona...te 6-phosphate aldolase and galactonate dehydratase || http://www.ncbi.nlm.nih.gov/protein/13475903 ...

Sequence Classification: 432685 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|23098931|ref|NP_692397.1| RNA polymerase sporulation...-specific sigma G factor; stage III sporulation protein G || http://www.ncbi.nlm.nih.gov/protein/23098931 ...

Sequence Classification: 790516 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|17570599|ref|NP_509691.1| dauer or Aging adult Overexpre...ssion DAO-4, putative protein (dao-4) || http://www.ncbi.nlm.nih.gov/protein/17570599 ...

Sequence Classification: 787239 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|17568735|ref|NP_509362.1| dauer or Aging adult Overexpre...ssion DAO-3, methylenetetrahydrofolate dehydrogenase (dao-3) || http://www.ncbi.nlm.nih.gov/protein/17568735 ...

Sequence Classification: 787569 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|17570599|ref|NP_509691.1| dauer or Aging adult Overexpre...ssion DAO-4, putative protein (dao-4) || http://www.ncbi.nlm.nih.gov/protein/17570599 ...

Sequence Classification: 790186 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|17568735|ref|NP_509362.1| dauer or Aging adult Overexpre...ssion DAO-3, methylenetetrahydrofolate dehydrogenase (dao-3) || http://www.ncbi.nlm.nih.gov/protein/17568735 ...

Sequence Classification: 785961 [

Lifescience Database Archive (English)

Full Text Available hways (157.5 kD) (aex-3) || http://www.ncbi.nlm.nih.gov/protein/25147747 ... ...ulsion defective AEX-3, Rab3 Guanine nucleotide Exchange Factor, regulator of presynaptic activity, regulates the rab-3 and cab-1 pat

Sequence Classification: 891407 [

Lifescience Database Archive (English)

Full Text Available ive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; Trx2p || http://www.ncbi.nlm.nih.gov/protein/6321648 ...

Sequence Classification: 889222 [

Lifescience Database Archive (English)

Full Text Available protein required for chromosome condensation, likely to function as an intrinsic component of the condensation machinery, may influe...nce multiple aspects of chromosome transmission and dynamics; Brn1p || http://www.ncbi.nlm.nih.gov/protein/41629672 ...

Sequence Classification: 397085 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|15607833|ref|NP_215207.1| PROBABLE COENZYME... PQQ SYNTHESIS PROTEIN E PQQE (COENZYME PQQ SYNTHESIS PROTEIN III) || http://www.ncbi.nlm.nih.gov/protein/15607833 ...

Sequence Classification: 387366 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|31791877|ref|NP_854370.1| PROBABLE COENZYME... PQQ SYNTHESIS PROTEIN E PQQE (COENZYME PQQ SYNTHESIS PROTEIN III) || http://www.ncbi.nlm.nih.gov/protein/31791877 ...

Sequence Classification: 515518 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|39935702|ref|NP_947978.1| possible nitrogen...ase molybdenum-iron protein alpha chain (nitrogenase component I) (dinitrogenase) || http://www.ncbi.nlm.nih.gov/protein/39935702 ...

Sequence Classification: 515248 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|39935432|ref|NP_947708.1| possible nitrogen...ase molybdenum-iron protein alpha chain (nitrogenase component I) (dinitrogenase) || http://www.ncbi.nlm.nih.gov/protein/39935432 ...

Sequence Classification: 514328 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|39934511|ref|NP_946787.1| putative nitrogen...ase molybdenum-iron protein alpha chain (nitrogenase component I) (dinitrogenase) || http://www.ncbi.nlm.nih.gov/protein/39934511 ...

Sequence Classification: 515233 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|39935417|ref|NP_947693.1| possible nitrogen...ase molybdenum-iron protein alpha chain (nitrogenase component I) (dinitrogenase) || http://www.ncbi.nlm.nih.gov/protein/39935417 ...

Sequence Classification: 777016 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH TMB TMB TMB Non-TMB >gi|25151905|ref|NP_502519.2| cytoplasmic Dynein Light... chain, Intermediate type, Dynein Light Intermediate chain (48.4 kD) (dli-1) || http://www.ncbi.nlm.nih.gov/protein/25151905 ...

Sequence Classification: 748315 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|30688528|ref|NP_850343.1| touch...-responsive protein / calmodulin-related protein 3, touch-induced (TCH3) || http://www.ncbi.nlm.nih.gov/protein/30688528 ...

Sequence Classification: 748314 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|15226833|ref|NP_181643.1| touch...-responsive protein / calmodulin-related protein 3, touch-induced (TCH3) || http://www.ncbi.nlm.nih.gov/protein/15226833 ...

Genetics Home Reference: nonsyndromic hearing loss

Science.gov (United States)

... Centre for Genetics Education (Australia) Disease InfoSearch: Deafness Harvard Medical School Center for Hereditary Deafness Hereditary Hearing ... Available from http://www.ncbi.nlm.nih.gov/books/NBK1434/ Citation on ... Bulletins Genetics Home Reference Celebrates Its 15th Anniversary ...

Sequence Classification: 60852 [

Lifescience Database Archive (English)

Full Text Available ihydroxy-2-butanone-4-phoshate synthase/GTP cyclohydrolase II || http://www.ncbi.nlm.nih.gov/protein/17934663 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|17934663|ref|NP_531453.1| 3,4-d

Sequence Classification: 387772 [

Lifescience Database Archive (English)

Full Text Available E CELA2B (ENDO-1,4-BETA-GLUCANASE) (ENDOGLUCANASE) (CARBOXYMETHYL CELLULASE) || http://www.ncbi.nlm.nih.gov/protein/31792283 ... ...Non-TMB Non-TMH TMB TMB TMB Non-TMB >gi|31792283|ref|NP_854776.1| PROBABLE CELLULAS

Sequence Classification: 397489 [

Lifescience Database Archive (English)

Full Text Available E CELA2B (ENDO-1,4-BETA-GLUCANASE) (ENDOGLUCANASE) (CARBOXYMETHYL CELLULASE) || http://www.ncbi.nlm.nih.gov/protein/15608230 ... ...Non-TMB Non-TMH TMB TMB TMB Non-TMB >gi|15608230|ref|NP_215606.1| PROBABLE CELLULAS

Hemophilia A

Science.gov (United States)

... PA: Elsevier; 2016:chap 476. Srivastava A, Brewer AK, Mauser-Bunschoten EP, et al. Treatment Guidelines Working Group on Behalf of The World Federation Of Hemophilia. Haemophilia. 2013;19:e1-47. PMID: 22776238 www.ncbi.nlm.nih.gov/pubmed/ ...

Sequence Classification: 288227 [

Lifescience Database Archive (English)

Full Text Available rone, transcription antiterminator, affects expression of rpoS and uspA || http://www.ncbi.nlm.nih.gov/protein/16128606 ... ...Non-TMB Non-TMH Non-TMB TMB Non-TMB Non-TMB >gi|16128606|ref|NP_415156.1| RNA chape

Sequence Classification: 173020 [

Lifescience Database Archive (English)

Full Text Available ihydroxy-2-butanone-4-phoshate synthase/GTP cyclohydrolase II || http://www.ncbi.nlm.nih.gov/protein/27377726 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|27377726|ref|NP_769255.1| 3,4-d

Association of protein Z and factor VII gene polymorphisms with risk ...

Indian Academy of Sciences (India)

Protein Z (PZ) and factor (F) VII are two important factors in the clotting pathway ..... found in NCBI (http://www.ncbi.nlm.nih.gov/projects/SNP), chosen from the largest population .... power of this population-based case–control study was lim-.

Sequence Classification: 776402 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|17541890|ref|NP_501911.1| UDP-glucu...ronosyltransferase UGT1A01 family member (4L125) || http://www.ncbi.nlm.nih.gov/protein/17541890 ...

Sequence Classification: 563892 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|56698190|ref|YP_168562.1| zinc/manga...nese/iron ABC transporter, periplasmic zinc/manganese/iron-binding protein || http://www.ncbi.nlm.nih.gov/protein/56698190 ...

The first record of a fly of the family Milichiidae (Diptera) interacting with an ant of the genus Polyrhachis Smith, 1857 (Hymenoptera: Formicidae)

Czech Academy of Sciences Publication Activity Database

Yusah, K. M.; Fayle, Tom Maurice

-, č. 2 (2014), e4168 ISSN 1314-2828 Institutional support: RVO:60077344 Keywords : Formicidae * Polyrhachis illaudata * Myrma Subject RIV: EH - Ecology, Behaviour http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238064/pdf/biodiversity_data_journal-2-e4168.pdf

Sequence Classification: 776314 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|17539494|ref|NP_501822.1| C. elegans WNT... family member precursor (40.4 kD) (wnt-2) || http://www.ncbi.nlm.nih.gov/protein/17539494 ...

Sequence Classification: 770605 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|17532639|ref|NP_493668.1| C. elegans WNT... family member precursor (42.0 kD) (wnt-1) || http://www.ncbi.nlm.nih.gov/protein/17532639 ...

Sequence Classification: 889075 [

Lifescience Database Archive (English)

Full Text Available localizes to vacuolar membranes and punctate structures attached to the vacuole; Atg22p || http://www.ncbi.nlm.nih.gov/protein/6319811 ... ...he breakdown of autophagic vesicles in the vacuole during autophagy, putative integral membrane protein that

Sequence Classification: 897717 [

Lifescience Database Archive (English)

Full Text Available ar to yeast protoplast regeneration and killer toxin resistance protein || http://www.ncbi.nlm.nih.gov/protein/19113759 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|19113759|ref|NP_592847.1| simil

Sequence Classification: 388073 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH TMB TMB TMB Non-TMB >gi|31792584|ref|NP_855077.1| PROBABLE DNA-DIRECTED RNA POLYMER...ASE (OMEGA CHAIN) RPOZ (TRANSCRIPTASE OMEGA CHAIN) (RNA POLYMERASE OMEGA SUBUNIT) || http://www.ncbi.nlm.nih.gov/protein/31792584 ...

Sequence Classification: 397793 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH TMB TMB TMB Non-TMB >gi|15608529|ref|NP_215906.1| PROBABLE DNA-DIRECTED RNA POLYMER...ASE (OMEGA CHAIN) RPOZ (TRANSCRIPTASE OMEGA CHAIN) (RNA POLYMERASE OMEGA SUBUNIT) || http://www.ncbi.nlm.nih.gov/protein/15608529 ...

Sequence Classification: 407536 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH Non-TMB TMB Non-TMB TMB >gi|15829032|ref|NP_326392.1| DNA-DIRECTED RNA POLYMER...ASE ALPHA CHAIN (TRANSCRIPTASE ALPHA CHAIN) (RNA POLYMERASE ALPHA SUBUNIT)rpo || http://www.ncbi.nlm.nih.gov/protein/15829032 ...

Duplex formation between the sRNA DsrA and rpoS mRNA is not sufficient for efficient RpoS synthesis at low temperature

Czech Academy of Sciences Publication Activity Database

Hämmerle, H.; Večerek, Branislav; Resch, A.; Bläsi, U.

2013-01-01

Roč. 10, č. 12 (2013), s. 1834-1841 ISSN 1547-6286 Institutional support: RVO:61388971 Keywords : DsrA * Hfq * Riboregulation Subject RIV: EE - Microbiology, Virology Impact factor: 5.377, year: 2013 http://www.ncbi.nlm.nih.gov/pubmed/24448230

Sequence Classification: 889185 [

Lifescience Database Archive (English)

Full Text Available binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cyt...oskeleton organization; Abp1p || http://www.ncbi.nlm.nih.gov/protein/6319931 ...

Sequence Classification: 893601 [

Lifescience Database Archive (English)

Full Text Available the mitochondrial import receptor Tom70p for preprotein delivery; interacts with co-chaperones Cns1p, Cpr6p, Cpr7p, and Sti1p; Hsp82p || http://www.ncbi.nlm.nih.gov/protein/6325016 ...

Sequence Classification: 894064 [

Lifescience Database Archive (English)

Full Text Available al protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; Rpl18ap || http://www.ncbi.nlm.nih.gov/protein/6324452 ...

To Your Health: NLM update transcript - No longer rare virtual care

Science.gov (United States)

... MedlinePlus GO GO About MedlinePlus Site Map FAQs Customer Support Health Topics Drugs & Supplements Videos & Tools You ... should lead to operational efficiencies and increased patient loyalty' (end of quote). The perspective's authors conclude (and ...

Defining the next generation journal: The NLM-Elsevier interactive publications experiment.

Science.gov (United States)

Siegel, Elliot R; Lindberg, Donald A B; Campbell, Glen P; Harless, William G; Goodwin, C Rory

2010-01-01

A unique collaborative project to identify interactive enhancements to conventional-print journal articles, and to evaluate their contribution to readers' learning and satisfaction. It was hypothesized that (a) the enhanced article would yield more knowledge acquisition than the original article; (b) the interactivity aspects of the enhanced article would measurably contribute to the acquisition of knowledge; and (c) the enhancements to the original article would increase reader acceptance. Fifteen SNMA medical students, assumed to have a greater generational familiarity and comfort level with interactive electronic media, reviewed 12 articles published in three Elsevier clinical and basic science journals. They used the Student National Medical Association's asynchronous online discussion forum over a four month period to suggest desired enhancements to improve learning. "Prognostic Factors in Stage T1 Bladder Cancer", published in the journal Urology was selected by the investigators as presenting the best opportunity to incorporate many of the students' suggested interactive and presentational enhancements in the limited timeframe available prior to the established test date. Educational, statistical, and medical consultants assisted in designing a test protocol in which 51 second to fourth year medical students were randomly assigned to experimental and control conditions, and were administered either the original or enhanced interactive version of the article on individual computer workstations. Test subjects consisted of 23 participants in the control group (8 males, 15 females) and 28 participants in the experimental group (9 males, 19 females). All subjects completed pre- and post-test instruments which measured their knowledge gain on 30 true-false and multiple-choice questions, along with 7 Likert-type questions measuring acceptance of the articles' format. Time to completion was recorded with the experimental group taking 22 min on average compared to 18 min for the controls; pre- and post-test times were 6 and 7 min, respectively. Statistical comparisons were based on change scores using either the Student t-test or the Two Way Analysis of Variance or Covariance. Significance was set at α = 0.05 or better. on the dependent measure of knowledge acquisition showed no difference overall on the 30 questions, but learning gain was statistically significant for the subset of 10 questions that measured gain on content that was accessible by the user-invoked interactive features of the enhanced article. Further analyses revealed significant interactions by student year and gender. Second year students (11 in the control group, 8 in the experimental group) were the best performers in terms of knowledge acquisition from both articles. The female medical students received a larger learning gain from journal enhancements and interactivity components than their male counterparts. Acceptance overall was greater for the experimental group who rated the experience more favorably than the controls. Failure to consider human factors such as gender and learning style may obscure underlying differences and their impact on the interactive aspects of scientific publications. Preliminary findings suggest the need for further study to include a heavier focus on interactivity apart from presentational enhancements; a more rigorous treatment of time as a specific variable; and an expanded experimental design that evaluates acquisition, understanding, integration and acceptance as dependent measures.

To Your Health: NLM update transcript - Rebuilding public trust in science

Science.gov (United States)

... science is so uncertain that any opinion or political assertion is as valid as evidence' (end of ... we quote): 'It comes down to good science communication —not simply choosing the right words to explain ...

Sequence Classification: 378420 [

Lifescience Database Archive (English)

Full Text Available onate 6-phosphate aldolase and galactonate dehydratase || http://www.ncbi.nlm.nih.gov/protein/13476139 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|13476139|ref|NP_107709.1| similar to 2-oxo-3-deoxygalact

Sequence Classification: 892145 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|6323774|ref|NP_013845.1| Protein of unknown function, deleti...on causes sensitivity to thermal stress; Dlt1p || http://www.ncbi.nlm.nih.gov/protein/6323774 ...

Sequence Classification: 891391 [

Lifescience Database Archive (English)

Full Text Available kinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of x...ylulose; required for xylose fermentation by recombinant S. cerevisiae strains; Xks1p || http://www.ncbi.nlm.nih.gov/protein/6321633 ...

Sequence Classification: 890748 [

Lifescience Database Archive (English)

Full Text Available in, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachmen...t of kinetochores to the spindle during meiosis I and meiosis II; Spo13p || http://www.ncbi.nlm.nih.gov/protein/6321802 ...

Sequence Classification: 13038 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|15669589|ref|NP_248402.1| alignment in /usr/local/projec...ts/ARG/Intergenic/ARG_R584_orf2.nr || http://www.ncbi.nlm.nih.gov/protein/15669589 ...

Sequence Classification: 12660 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|15669211|ref|NP_248016.1| alignment in /usr/local/projec...ts/ARG/Intergenic/ARG_R428_orf1.nr || http://www.ncbi.nlm.nih.gov/protein/15669211 ...

Sequence Classification: 396442 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB TMB Non-TMB Non-TMB >gi|57116687|ref|YP_177689.1| POSSIBLE CELLULASE CELA1 (ENDOGLUCA...NASE) (ENDO-1,4-BETA-GLUCANASE) (FI-CMCASE) (CARBOXYMETHYL CELLULASE) || http://www.ncbi.nlm.nih.gov/protein/57116687 ...

Sequence Classification: 386728 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB TMB Non-TMB Non-TMB >gi|31791239|ref|NP_853732.1| POSSIBLE CELLULASE CELA1 (ENDOGLUCA...NASE) (ENDO-1,4-BETA-GLUCANASE) (FI-CMCASE) (CARBOXYMETHYL CELLULASE) || http://www.ncbi.nlm.nih.gov/protein/31791239 ...

Sequence Classification: 799288 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|58269116|ref|XP_571714.1| electron... transporter, transferring electrons within CoQH2-cytochrome c reductase complex, putative || http://www.ncbi.nlm.nih.gov/protein/58269116 ...

Medline Plus

Full Text Available ... MedlinePlus GO GO About MedlinePlus Site Map FAQs Customer Support Health Topics Drugs & Supplements Videos & Tools Español ... NLM Update Podcast About MedlinePlus Site Map FAQs Customer Support Get email updates Subscribe to RSS Follow ...

Sequence Classification: 779783 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH TMB TMB TMB Non-TMB >gi|17505713|ref|NP_492684.1| dauer or Aging adult Overexpress...ion DAO-5, SRP40, C-terminal (101.1 kD) (dao-5) || http://www.ncbi.nlm.nih.gov/protein/17505713 ...

Sequence Classification: 889842 [

Lifescience Database Archive (English)

Full Text Available region of Rcr1p in conferring Congo Red resistance when overexpressed; Rcr2p || http://www.ncbi.nlm.nih.gov/protein/6320206 ... ...lum membrane protein with similarity to Rcr1p; C-terminal region can functionally replace the corresponding

Sequence Classification: 889813 [

Lifescience Database Archive (English)

Full Text Available mplicated in myoclonus epilepsy associated with ragged red fibers (MERRF); Slm3p || http://www.ncbi.nlm.nih.gov/protein/6320172 ... ...2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is i

Sequence Classification: 501435 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH TMB TMB TMB Non-TMB >gi|66048305|ref|YP_238146.1| Heavy metal-(Cd/Co/Hg.../Pb/Zn)-translocating P-type ATPase:Heavy metal translocating P-type ATPase || http://www.ncbi.nlm.nih.gov/protein/66048305 ...

Sequence Classification: 400201 [

Lifescience Database Archive (English)

Full Text Available ECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE) TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER PROZ || http://www.ncbi.nlm.nih.gov/protein/15610892 ... ...Non-TMB TMH Non-TMB TMB TMB Non-TMB >gi|15610892|ref|NP_218273.1| POSSIBLE OSMOPROT

Sequence Classification: 390416 [

Lifescience Database Archive (English)

Full Text Available ECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE) TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER PROW || http://www.ncbi.nlm.nih.gov/protein/31794927 ... ...Non-TMB TMH Non-TMB TMB TMB Non-TMB >gi|31794927|ref|NP_857420.1| POSSIBLE OSMOPROT

Sequence Classification: 390415 [

Lifescience Database Archive (English)

Full Text Available ECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE) TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER PROZ || http://www.ncbi.nlm.nih.gov/protein/31794926 ... ...Non-TMB TMH Non-TMB TMB TMB Non-TMB >gi|31794926|ref|NP_857419.1| POSSIBLE OSMOPROT

Sequence Classification: 400202 [

Lifescience Database Archive (English)

Full Text Available ECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE) TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER PROW || http://www.ncbi.nlm.nih.gov/protein/15610893 ... ...Non-TMB TMH Non-TMB TMB TMB Non-TMB >gi|15610893|ref|NP_218274.1| POSSIBLE OSMOPROT

Sequence Classification: 504686 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB TMB TMB Non-TMB >gi|73540781|ref|YP_295301.1| ComEC/Rec2-related protein:DNA internaliza...tion-related competence protein ComEC/Rec2 || http://www.ncbi.nlm.nih.gov/protein/73540781 ...

Sequence Classification: 498007 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB TMB TMB Non-TMB >gi|66044877|ref|YP_234718.1| ComEC/Rec2-related protein:DNA internaliza...tion-related competence protein ComEC/Rec2 || http://www.ncbi.nlm.nih.gov/protein/66044877 ...

Sequence Classification: 257032 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB Non-TMB TMB Non-TMB >gi|71908445|ref|YP_286032.1| ComEC/Rec2-related protein:DNA interna...lization-related competence protein ComEC/Rec2 || http://www.ncbi.nlm.nih.gov/protein/71908445 ...

Sequence Classification: 772645 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB TMB >gi|25149956|ref|NP_495592.2| SYnapse Defective SYD-1, axon iden...tity specification protein (104.4 kD) (syd-1) || http://www.ncbi.nlm.nih.gov/protein/25149956 ...

Sequence Classification: 524859 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|62181272|ref|YP_217689.1| H inversion...: regulation of flagellar gene expression by site-specific inversion of DNA || http://www.ncbi.nlm.nih.gov/protein/62181272 ...

Sequence Classification: 386849 [

Lifescience Database Archive (English)

Full Text Available ERASE SIGMA FACTOR SIGG (RNA POLYMERASE ECF TYPE SIGMA FACTOR) || http://www.ncbi.nlm.nih.gov/protein/31791360 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|31791360|ref|NP_853853.1| PROBABLE ALTERNATIVE RNA POLYM

Sequence Classification: 407520 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB TMB >gi|15829016|ref|NP_326376.1| DNA-DIRECTED RNA POLYMER...ASE BETA' CHAIN (TRANSCRIPTASE BETA' CHAIN) (RNA POLYMERASE BETA' SUBUNIT) || http://www.ncbi.nlm.nih.gov/protein/15829016 ...

Sequence Classification: 396563 [

Lifescience Database Archive (English)

Full Text Available ERASE SIGMA FACTOR SIGG (RNA POLYMERASE ECF TYPE SIGMA FACTOR) || http://www.ncbi.nlm.nih.gov/protein/15607323 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|15607323|ref|NP_214696.1| PROBABLE ALTERNATIVE RNA POLYM

Sequence Classification: 407521 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB TMB >gi|15829017|ref|NP_326377.1| DNA-DIRECTED RNA POLYMER...ASE BETA CHAIN (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) || http://www.ncbi.nlm.nih.gov/protein/15829017 ...

77 FR 59624 - Submission for OMB Review; Comment Request; CareerTrac

Science.gov (United States)

2012-09-28

... collection system provides a streamlined, web-based application permitting Principal Investigators to record... (NIGMS), National Cancer Institute (NCI), and National Library of Medicine (NLM) of the National....: 0925-0568). Need and Use of Information Collection: This data collection system is being developed to...

Readability of patient education materials available at the point of care.

Science.gov (United States)

Stossel, Lauren M; Segar, Nora; Gliatto, Peter; Fallar, Robert; Karani, Reena

2012-09-01

Many patient education materials (PEMs) available on the internet are written at high school or college reading levels, rendering them inaccessible to the average US resident, who reads at or below an 8(th) grade level. Currently, electronic health record (EHR) providers partner with companies that produce PEMs, allowing clinicians to access PEMs at the point of care. To assess the readability of PEMs provided by a popular EHR vendor as well as the National Library of Medicine (NLM). We included PEMs from Micromedex, EBSCO, and MedlinePlus. Micromedex and EBSCO supply PEMs to Meditech, a popular EHR supplier in the US. MedlinePlus supplies the NLM. These PEM databases have high market penetration and accessibility. Grade reading level of the PEMs was calculated using three validated indices: Simple Measure of Gobbledygook (SMOG), Gunning Fog (GFI), and Flesch-Kincaid (FKI). The percentage of documents above target readability and average readability scores from each database were calculated. We randomly sampled 100 disease-matched PEMs from three databases (n = 300 PEMs). Depending on the readability index used, 30-100% of PEMs were written above the 8(th) grade level. The average reading level for MedlinePlus, EBSCO, and Micromedex PEMs was 10.2 (1.9), 9.7 (1.3), and 8.6 (0.9), respectively (p ≤ 0.000) as estimated by the GFI. Estimates of readability using SMOG and FKI were similar. The majority of PEMS available through the NLM and a popular EHR were written at reading levels considerably higher than that of the average US adult.

Sequence Classification: 894385 [

Lifescience Database Archive (English)

Full Text Available t of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates tra...nscriptional silencing; stimulates Sas2p HAT activity; Sas5p || http://www.ncbi.nlm.nih.gov/protein/6324787 ...

Sequence Classification: 889355 [

Lifescience Database Archive (English)

Full Text Available d transporter and very long-chain fatty acyl-CoA synthetase, may form a complex with Faa1p or Faa4p that imports and activates exogen...ous fatty acids; Fat1p || http://www.ncbi.nlm.nih.gov/protein/41629676 ...

Theater Sustainment Reserve for the Rwanda Defence Forces

Science.gov (United States)

2016-06-10

The East African magazine stated that the illegal armed group operating in the eastern DRC was moving into Burundi (Magical 2015). Rwanda’s...Gisenyi District Hospital in Rwanda.” National Center for Biotechnology Information. Accessed 31 March 2016. http://www.ncbi.nlm.nih.gov/books

Sequence Classification: 891278 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH TMB TMB TMB Non-TMB >gi|6321518|ref|NP_011595.1| Protein of unknown function; deletion... mutant has synthetic fitness defect with an sgs1 deletion mutant; Slx9p || http://www.ncbi.nlm.nih.gov/protein/6321518 ...

Sequence Classification: 892983 [

Lifescience Database Archive (English)

Full Text Available r protein of unknown function; deletion results in sensitivity to anticancer drugs oxaliplatin and cisplatin..., but not mitomycin C; deletion is synthetically lethal with a chitin synthase (CHS1) null mutant; Psy2p || http://www.ncbi.nlm.nih.gov/protein/6324128 ...

Sequence Classification: 889737 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB TMB Non-TMB >gi|44829553|ref|NP_010168.3| Protein of unknown function, delet...ion causes hypersensitivity to the K1 killer toxin; Iwr1p || http://www.ncbi.nlm.nih.gov/protein/44829553 ...

Sequence Classification: 891686 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH Non-TMB TMB Non-TMB Non-TMB >gi|6320838|ref|NP_010917.1| Constituent of 66S pre-ribosomal partic...les, involved in 60S ribosomal subunit biogenesis; Nop16p || http://www.ncbi.nlm.nih.gov/protein/6320838 ...

Sequence Classification: 890172 [

Lifescience Database Archive (English)

Full Text Available ity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal level...s relative to other HXTs, expression repressed by high glucose levels; Hxt7p || http://www.ncbi.nlm.nih.gov/protein/6320549 ...

"Without Research, There Is No Hope!"

Science.gov (United States)

... who represented West Palm Beach, Fla., for 24 years, he was known as "Mr. Health" for his leading role in passing key environmental and health care legislation. "Paul Rogers was one of the best friends ever of the National Library of Medicine," noted NLM ...

Sequence Classification: 893543 [

Lifescience Database Archive (English)

Full Text Available rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein parti...cles (snoRNPs); immunologically and structurally to rat Nopp140; Srp40p || http://www.ncbi.nlm.nih.gov/protein/6322945 ...

Serum and bone pentosidine in patients with low impact hip fractures and in patients with advanced osteoarthritis

Czech Academy of Sciences Publication Activity Database

Vaculík, J.; Braun, Martin; Dungl, P.; Pavelka, K.; Štěpán jr., J.

2016-01-01

Roč. 17, č. 1 (2016), s. 308 E-ISSN 1471-2474 Institutional support: RVO:67985891 Keywords : biomarkers * osteoarthritis * osteoporosis * pentosidine * proximal femoral fracture Subject RIV: FI - Traumatology, Orthopedics Impact factor: 1.739, year: 2016 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957857/

Genetics Home Reference: alcohol use disorder

Science.gov (United States)

... use disorder can cause major health, social, and economic problems, and can endanger affected individuals and others ... Available from http://www.ncbi.nlm.nih.gov/books/NBK424857/ Citation on PubMed Zhu EC, Soundy TJ, ... Bulletins Genetics Home Reference Celebrates Its 15th Anniversary ...

Sequence Classification: 750628 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|18414374|ref|NP_567455.1| far-red impai...red response protein (FAR1) / far-red impaired responsive protein (FAR1) || http://www.ncbi.nlm.nih.gov/protein/18414374 ...

Sequence Classification: 889214 [

Lifescience Database Archive (English)

Full Text Available elix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrog...rade (RTG) and TOR pathways; Rtg3p || http://www.ncbi.nlm.nih.gov/protein/6319365 ...

Sequence Classification: 891113 [

Lifescience Database Archive (English)

Full Text Available zed to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p; Use1p || http://www.ncbi.nlm.nih.gov/protein/6321340 ...

Sequence Classification: 893846 [

Lifescience Database Archive (English)

Full Text Available ds zinc, found both on membranes and in the cytosol; guanine nucleotide dissociation stimulator; Dss4p || http://www.ncbi.nlm.nih.gov/protein/6325274 ... ...tide release factor functioning in the post-Golgi secretory pathway, required for ER-to-Golgi transport, bin

Frequently Asked Questions about Genetic Counseling

Science.gov (United States)

... a decision about testing. Interpret the results of genetic tests and medical data. Provide counseling or refer individuals and families to support services. Serve as patient advocates. Explain possible treatments or preventive ... What is a genetic consultation? [ghr.nlm.nih.gov] Top of page ...

Sequence Classification: 400354 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|57117168|ref|YP_178026.1| PROBABLE POLY(A) POLYMER...ASE PCNA (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) (NTP POLYMERASE) (RNA ADENYLATING ENZYME) (POLY(A) POLYMERASE) || http://www.ncbi.nlm.nih.gov/protein/57117168 ...

Sequence Classification: 387341 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|31791852|ref|NP_854345.1| DNA-DIRECTED RNA POLYMER...ASE (BETA' CHAIN) RPOC (TRANSCRIPTASE BETA' CHAIN) (RNA POLYMERASE BETA' SUBUNIT). || http://www.ncbi.nlm.nih.gov/protein/31791852 ...

Sequence Classification: 390569 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|31795080|ref|NP_857573.1| POLY(A) POLYMER...ASE PCNA (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) (NTP POLYMERASE) (RNA ADENYLATING ENZYME) (POLY(A) POLYMERASE) || http://www.ncbi.nlm.nih.gov/protein/31795080 ...

Sequence Classification: 778309 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|17505691|ref|NP_491292.1| UNCoordinate...d locomotion UNC-89, PHarynx Muscle abnormal PHM-1, uncoordinated protein 89 (unc-89) || http://www.ncbi.nlm.nih.gov/protein/17505691 ...

Utilization of PMTCT services at Juba Teaching Hospital, South Sudan

African Journals Online (AJOL)

Six mothers were not using any mode of family planning, one used condoms, one had an IUCD and one used dates. (natural) .... associated with increase in CD4 cell count of 15.1 cells/ .... 2652-14-61http://www.ncbi.nlm.nih.gov/pmc/articles/.

Healthy food trends -- chia seeds

Science.gov (United States)

... fatty acids for healthy adults. J Acad Nutr Diet . 2014;114(1):136-153. PMID: 24342605 www.ncbi.nlm.nih.gov/pubmed/24342605 . Review Date 4/24/2016 Updated by: Emily Wax, RD, The Brooklyn Hospital Center, Brooklyn, NY. Also reviewed by David Zieve, ...

The U.S. National Library of Medicine's Toxicology and Environmental Health Information Program

International Nuclear Information System (INIS)

Wexler, Philip

2004-01-01

For nearly 40 years, the National Library of Medicine's (NLM) Toxicology and Environmental Health Information Program (TEHIP) has been a significant leader in organizing and providing public access to an extensive storehouse of toxicological information through its online databases. With the advent of the Internet, TEHIP has expanded its role to also serve as a pre-eminent portal to toxicological information worldwide. Its primary databases reside within the web-based TOXNET system, and include the scientifically peer-reviewed Hazardous Substances Data Bank (HSDB), the U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) and Toxics Release Inventory, the National Cancer Institute's Chemical Carcinogenesis Research Information System (CCRIS) and the TOXLINE file of over 3 million bibliographic references. TEHIP's ChemIDplus is an extensive chemical dictionary that extends beyond simple nomenclature to offer displays of molecular structures and links from particular chemicals to other databases containing more information. Specialty files in occupational safety and health, and household products have recently been added to TEHIP's suite of resources. Additional databases in risk assessment, drugs, toxicology education, and global resources, are under development. ''Special Topics'' pages lead users to structured summaries and links in areas such as arsenic, chemical warfare agents, biological warfare, and West Nile Virus. A database on alternatives to the use of live animals, a three-module toxicology tutor, and a glossary of terms in toxicology are among TEHIP's other information aids, as well an increasing commitment to serving consumers, as witnessed by the animated ToxTown program. Outside the sphere of TEHIP, NLM offers additional databases, such as PubMed, of significant value to toxicology researchers

Sequence Classification: 889834 [

Lifescience Database Archive (English)

Full Text Available ritance; deletion reveals defects in precursor tRNA splicing, sporulation and cell separation; Ptc1p || http://www.ncbi.nlm.nih.gov/protein/6320198 ... ...C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inhe

Could Continuous Glucose Monitoring Facilitate Identifying Diabetes Patients with a Higher Risk of Hypoglycemia during Driving?

Czech Academy of Sciences Publication Activity Database

Brož, J.; Doničová, V.; Brabec, Marek; Janíčková Žďárská, D.; Polák, J.

2013-01-01

Roč. 7, č. 6 (2013), s. 1644-1645 ISSN 1932-2968 Institutional support: RVO:67985807 Keywords : continuous glucose monitoring * driving * hypoglycemia * insulin pump * prevention * type 1 diabetes mellitus Subject RIV: BB - Applied Statistics, Operational Research http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876343/

Genes in FRA16D and FRA7G Mutated in Prostate Cancer.

Science.gov (United States)

1999-06-01

also known as pancreatic CPs. the digestive enzymes involved in the hydrolysis of alimentary proteins, which are expressed and secreted into the...Institute site at the National Center of Biotechnology Information (NCBI) Human gene map Project at HYPERLINK http://www.ncbi.nlm.nih.gov/cgi-bin

Sequence Classification: 894820 [

Lifescience Database Archive (English)

Full Text Available ruption does not increase the rate of spontaneous mutagenesis; Ham1p || http://www.ncbi.nlm.nih.gov/protein/6322529 ... ...n of unknown function that is involved in DNA repair; mutant is sensitive to the base analog, 6-N-hydroxylaminopurine, while gene dis

Sequence Classification: 893448 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|6322843|ref|NP_012916.1| Protein involved in mRNA turnov...er and ribosome assembly, localizes to the nucleolus; Mrt4p || http://www.ncbi.nlm.nih.gov/protein/6322843 ...

Sequence Classification: 119807 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|52081840|ref|YP_080631.1| Heavy met...al-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase,Heavy metal translocating P-type ATPase || http://www.ncbi.nlm.nih.gov/protein/52081840 ...

Sequence Classification: 501191 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|66048061|ref|YP_237902.1| Heavy met...al-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase:Heavy metal translocating P-type ATPase || http://www.ncbi.nlm.nih.gov/protein/66048061 ...

Sequence Classification: 769798 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|17552758|ref|NP_499097.1| yeast CLU (mitochondrial clust...ering) related, related to yeast mitochondrial CLUstering (139.9 kD) (clu-1) || http://www.ncbi.nlm.nih.gov/protein/17552758 ...

Literacy in India and the Example of Kerala (Changes in Literacy).

Science.gov (United States)

Chandran, K. Narayana

1994-01-01

Discusses the National Literacy Mission (NLM) launched in 1988 in India. Notes the barriers to successful campaigns for literacy in India. Describes the reasons for the particularly successful campaign in the state of Kerala, including the fact that it was in every sense a people's campaign. (SR)

Teaching Environmental Health Science for Informed Citizenship in the Science Classroom and Afterschool Clubs

Science.gov (United States)

Keselman, Alla; Levin, Daniel M.; Hundal, Savreen; Kramer, Judy F.; Matzkin, Karen; Dutcher, Gale

2013-01-01

In the era of growing concerns about human-induced climate change and sustainable development, it is important for the schools to prepare students for meaningful engagement with environmental policies that will determine the future of our society. To do this, educators need to face a number of challenges. These include deciding on the science knowledge and skills needed for informed citizenship, identifying teaching practices for fostering such knowledge and skills, and finding ways to implement new practices into the tightly packed existing curriculum. This paper describes two collaborative efforts between the U.S. National Library of Medicine (NLM) and University of Maryland College of Education that attempt to meet these challenges. The focus of both projects is on helping students develop information seeking and evaluation and argumentation skills, and applying them to complex socio-scientific issues that have bearing on students’ daily lives. The first effort involves co-designing an afterschool environmental health club curriculum with an interdisciplinary team of middle school teachers. The second effort is the development and implementation of a week-long school drinking water quality debate activity in a high school environmental science classroom. Both projects center on Tox Town, an NLM web resource that introduces students to environmental health issues in everyday environments. The paper describes successes and challenges of environmental health curriculum development, including teachers’ and researchers’ perception of contextual constraints in the club and classroom setting, tensions inherent in co-design, and students’ experience with socio-scientific argumentation. PMID:24382985

The Visualization of the Space Probability Distribution for a Particle Moving in a Double Ring-Shaped Coulomb Potential

Directory of Open Access Journals (Sweden)

Yuan You

2018-01-01

Full Text Available The analytical solutions to a double ring-shaped Coulomb potential (RSCP are presented. The visualizations of the space probability distribution (SPD are illustrated for the two- (contour and three-dimensional (isosurface cases. The quantum numbers (n,l,m are mainly relevant for those quasi-quantum numbers (n′,l′,m′ via the double RSCP parameter c. The SPDs are of circular ring shape in spherical coordinates. The properties for the relative probability values (RPVs P are also discussed. For example, when we consider the special case (n,l,m=(6,5,0, the SPD moves towards two poles of z-axis when P increases. Finally, we discuss the different cases for the potential parameter b, which is taken as negative and positive values for c>0. Compared with the particular case b=0, the SPDs are shrunk for b=-0.5, while they are spread out for b=0.5.

Fracture Mechanics Method for Word Embedding Generation of Neural Probabilistic Linguistic Model.

Science.gov (United States)

Bi, Size; Liang, Xiao; Huang, Ting-Lei

2016-01-01

Word embedding, a lexical vector representation generated via the neural linguistic model (NLM), is empirically demonstrated to be appropriate for improvement of the performance of traditional language model. However, the supreme dimensionality that is inherent in NLM contributes to the problems of hyperparameters and long-time training in modeling. Here, we propose a force-directed method to improve such problems for simplifying the generation of word embedding. In this framework, each word is assumed as a point in the real world; thus it can approximately simulate the physical movement following certain mechanics. To simulate the variation of meaning in phrases, we use the fracture mechanics to do the formation and breakdown of meaning combined by a 2-gram word group. With the experiments on the natural linguistic tasks of part-of-speech tagging, named entity recognition and semantic role labeling, the result demonstrated that the 2-dimensional word embedding can rival the word embeddings generated by classic NLMs, in terms of accuracy, recall, and text visualization.

Quality of patient education materials for rehabilitation after neurological surgery.

Science.gov (United States)

Agarwal, Nitin; Sarris, Christina; Hansberry, David R; Lin, Matthew J; Barrese, James C; Prestigiacomo, Charles J

2013-01-01

To evaluate the quality of online patient education materials for rehabilitation following neurological surgery. Materials were obtained from the National Institute of Neurological Disorders and Stroke (NINDS), U.S. National Library of Medicine (NLM), American Occupational Therapy Association (AOTA), and the American Academy of Orthopaedic Surgeons (AAOS). After removing unnecessary formatting, the readability of each site was assessed using the Flesch Reading Ease and Flesch-Kincaid Grade Level evaluations with Microsoft Office Word software. The average values of the Flesch Reading Ease and Flesch-Kincaid Grade Level were 41.5 and 11.8, respectively, which are well outside the recommended reading levels for the average American. Moreover, no online section was written below a ninth grade reading level. Evaluations of several websites from the NINDS, NLM, AOTA, and AAOS demonstrated that their reading levels were higher than that of the average American. Improved readability might be beneficial for patient education. Ultimately, increased patient comprehension may correlate to positive clinical outcomes.

Natural language processing: state of the art and prospects for significant progress, a workshop sponsored by the National Library of Medicine.

Science.gov (United States)

Friedman, Carol; Rindflesch, Thomas C; Corn, Milton

2013-10-01

Natural language processing (NLP) is crucial for advancing healthcare because it is needed to transform relevant information locked in text into structured data that can be used by computer processes aimed at improving patient care and advancing medicine. In light of the importance of NLP to health, the National Library of Medicine (NLM) recently sponsored a workshop to review the state of the art in NLP focusing on text in English, both in biomedicine and in the general language domain. Specific goals of the NLM-sponsored workshop were to identify the current state of the art, grand challenges and specific roadblocks, and to identify effective use and best practices. This paper reports on the main outcomes of the workshop, including an overview of the state of the art, strategies for advancing the field, and obstacles that need to be addressed, resulting in recommendations for a research agenda intended to advance the field. Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

Epidemiology of West Nile in Europe and in the Mediterranean Basin

Czech Academy of Sciences Publication Activity Database

Calistri, P.; Giovannini, A.; Hubálek, Zdeněk; Ionescu, A.; Monaco, F.; Savini, G.; Lelli, R.

2010-01-01

Roč. 4, - (2010), s. 29-37 ISSN 1874-3579 Institutional research plan: CEZ:AV0Z60930519 Keywords : Epidemiology * Europe * West Nile * Mediterranean Basin Subject RIV: FN - Epidemiology, Contagious Diseases ; Clinical Immunology http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878979/pdf/TOVJ-4-29.pdf

Sequence Classification: 782533 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|17561778|ref|NP_504835.1| dauer or Aging adult Overexpre...ssion DAO-1, FK506 Binding protein family (29.1 kD) (fkb-3) || http://www.ncbi.nlm.nih.gov/protein/17561778 ...

Sequence Classification: 783965 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|17561780|ref|NP_506197.1| dauer or Aging adult Overexpre...ssion DAO-9, FK506 Binding protein family (29.3 kD) (fkb-4) || http://www.ncbi.nlm.nih.gov/protein/17561780 ...

Development of a Novel Therapeutic Paradigm Utilizing a Mammary Gland-Targeted, Bin1-Knockout Mouse Model

Science.gov (United States)

2008-07-01

genes in higher organisms— Homo sapiens gene INDO, encoding indole- amine-pyrrole 2,3 dioxygenase. Available from http://www.ncbi.nlm.nih.gov/IEB...Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB. J Biol Chem 1997; 272:15591–4. 25. Routhier EL , Donover PS

Sequence Classification: 767777 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|17553792|ref|NP_497224.1| FEMinization of XX and XO anim...als FEM-2, protein phosphatase FEM-2 (50.9 kD) (fem-2) || http://www.ncbi.nlm.nih.gov/protein/17553792 ...

Sequence Classification: 890420 [

Lifescience Database Archive (English)

Full Text Available chrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly express...ed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; Cox5bp || http://www.ncbi.nlm.nih.gov/protein/6322080 ...

Sequence Classification: 774832 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|25145175|ref|NP_500386.2| acetylcholi...ne transporter, abnormal CHoline Acetyltransferase CHA-1, UNCoordinated locomotion UNC-17 (58.6 kD) (unc-17+cha-1) || http://www.ncbi.nlm.nih.gov/protein/25145175 ...

Sequence Classification: 774831 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|25145178|ref|NP_500387.2| choli...ne acetyltransferase, abnormal CHoline Acetyltransferase CHA-1, UNCoordinated locomotion UNC-17 (71.3 kD) (unc-17+cha-1) || http://www.ncbi.nlm.nih.gov/protein/25145178 ...

Sequence Classification: 769053 [

Lifescience Database Archive (English)

Full Text Available ulinase-like peptidase, family M16 (111.2 kD) (3H529) || http://www.ncbi.nlm.nih.gov/protein/17552016 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|17552016|ref|NP_498412.1| peptidase M16 inactive and ins

Sequence Classification: 890890 [

Lifescience Database Archive (English)

Full Text Available lar protein of unknown function, positive regulator of exit from mitosis; involved in regulating the release of Cdc14p from the nucle...olus in early anaphase; proposed to play similar role in meiosis; Spo12p || http://www.ncbi.nlm.nih.gov/protein/6321946 ...

Sequence Classification: 893705 [

Lifescience Database Archive (English)

Full Text Available inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; associa...tion with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p; Cox11p || http://www.ncbi.nlm.nih.gov/protein/6325125 ...

Sequence Classification: 891153 [

Lifescience Database Archive (English)

Full Text Available calized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the deliv...ery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; Erv14p || http://www.ncbi.nlm.nih.gov/protein/6321384 ...

Sequence Classification: 892076 [

Lifescience Database Archive (English)

Full Text Available it network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, ...blocks cell cycle progression before anaphase in response to spindle and kinetochore damage; Bub2p || http://www.ncbi.nlm.nih.gov/protein/6323700 ...

Sequence Classification: 891427 [

Lifescience Database Archive (English)

Full Text Available TMB Non-TMH TMB TMB TMB TMB >gi|50593217|ref|NP_011747.2| Subunit of the prohibitin complex (Phb1p-Phb2p...ynthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; Phb2p || http://www.ncbi.nlm.nih.gov/protein/50593217 ...

Sandia National Laboratories/New Mexico Environmental Information Document - Volume II

Energy Technology Data Exchange (ETDEWEB)

GUERRERO, JOSEPH V.; KUZIO, KENNETH A.; JOHNS, WILLIAM H.; BAYLISS, LINDA S.; BAILEY-WHITE, BRENDA E.

1999-09-01

This Sandia National Laboratories/New Mexico Environmental Information Document (EID) compiles information on the existing environment, or environmental baseline, for SNUNM. Much of the information is drawn from existing reports and databases supplemented by new research and data. The SNL/NM EID, together with the Sandia National Laboratories/New Mexico Facilities and Safety Information Document, provide a basis for assessing the environment, safety, and health aspects of operating selected facilities at SNL/NM. The environmental baseline provides a record of the existing physical, biological, and socioeconomic environment at SNL/NLM prior to being altered (beneficially or adversely) by proposed programs or projects. More specifically, the EID provides information on the following topics: Geology; Land Use; Hydrology and Water Resources; Air Quality and Meteorology; Ecology; Noise and Vibration; Cultural Resources; Visual Resources; Socioeconomic and Community Services; Transportation; Material Management; Waste Management; and Regulatory Requirements.

Sandia National Laboratories/New Mexico Environmental Information Document - Volume 1

Energy Technology Data Exchange (ETDEWEB)

BAYLISS, LINDA S.; GUERRERO, JOSEPH V.; JOHNS, WILLIAM H.; KUZIO, KENNETH A.; BAILEY-WHITE, BRENDA E.

1999-09-01

This Sandia National Laboratories/New Mexico Environmental Information Document (EID) compiles information on the existing environment, or environmental baseline, for SNUNM. Much of the information is drawn from existing reports and databases supplemented by new research and data. The SNL/NM EID, together with the Sandia National Laboratories/New Mexico Facilities and Safety Information Document, provide a basis for assessing the environment, safety, and health aspects of operating selected facilities at SNL/NM. The environmental baseline provides a record of the existing physical, biological, and socioeconomic environment at SNL/NLM prior to being altered (beneficially or adversely) by proposed programs or projects. More specifically, the EID provides information on the following topics: Geology; Land Use; Hydrology and Water Resources; Air Quality and Meteorology; Ecology; Noise and Vibration; Cultural Resources; Visual Resources; Socioeconomic and Community Services; Transportation; Material Management; Waste Management; and Regulatory Requirements.

Sequence Classification: 890431 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH TMB Non-TMB TMB TMB >gi|6322092|ref|NP_012167.1| Intracellular sporulation...-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation..., but dispensable for sporulation; Sga1p || http://www.ncbi.nlm.nih.gov/protein/6322092 ...

Sequence Classification: 890824 [

Lifescience Database Archive (English)

Full Text Available hyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth; Ste12p || http://www.ncbi.nlm.nih.gov/protein/6321876 ... ...ion factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudo

Sequence Classification: 778660 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|17507815|ref|NP_491621.1| the gene is express...ed protein retains C2H2 zinc-finger at its N-terminal region. like (1G100) || http://www.ncbi.nlm.nih.gov/protein/17507815 ...

Sequence Classification: 889633 [

Lifescience Database Archive (English)

Full Text Available d septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud n...eck which is necessary for normal morphogenesis and cytokinesis; Shs1p || http://www.ncbi.nlm.nih.gov/protein/6319976 ...

Evolution and structural diversification of PILS putative auxin carriers in plants

Czech Academy of Sciences Publication Activity Database

Feraru, E.; Vosolsobě, S.; Feraru, M.; Petrášek, Jan; Kleine-Vehn, J.

2012-01-01

Roč. 3, č. 227 (2012) ISSN 1664-462X R&D Projects: GA ČR(CZ) GAP305/11/2476 Institutional support: RVO:61389030 Keywords : PILS proteins * auxin * evolution Subject RIV: EB - Genetics ; Molecular Biology http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470039/pdf/fpls-03-00227.pdf

Post-Traumatic Stress Disorder and the Military: A Selected Bibliography

Science.gov (United States)

2011-06-01

traumatic brain injury. As of June 15, 2011, a section de- voted to Military Transition was still under construction. http://www.familyofavet.com PBS...1-14. http://www.ncbi.nlm. nih.gov/pmc/articles/PMC3057553/pdf/fneur-02-00012.pdf?tool=pmcentrez Levin, Harvey S., et al. “Diffusion Tensor

Sequence Classification: 893428 [

Lifescience Database Archive (English)

Full Text Available e subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening; Tfa1p || http://www.ncbi.nlm.nih.gov/protein/6322824 ... ...Non-TMB Non-TMH Non-TMB Non-TMB TMB Non-TMB >gi|6322824|ref|NP_012897.1| TFIIE larg

Sequence Classification: 892995 [

Lifescience Database Archive (English)

Full Text Available TMB TMH Non-TMB TMB TMB TMB >gi|6324141|ref|NP_014211.1| Essential protein involved in karyoga...e of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p; Kar1p || http://www.ncbi.nlm.nih.gov/protein/6324141 ...

76 FR 256 - Informed Consent Elements

Science.gov (United States)

2011-01-04

....ClinicalTrials.gov Web site in order to enhance the system of checks and balances for the research... registry databank maintained by the National Institutes of Health/National Library of Medicine (NIH/ NLM... students, and others. To make it easier to identify comments and our responses, the word ``Comment,'' in...

Sequence Classification: 889823 [

Lifescience Database Archive (English)

Full Text Available dback control mechanism; RPN4 is transcriptionally regulated by various stress responses; Rpn4p || http://www.ncbi.nlm.nih.gov/protein/6320184 ... ...ion factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative fee

NLM Informationist Grant – Web Assisted Tobacco Intervention for Community College Students

Directory of Open Access Journals (Sweden)

Linda Hasman

2013-05-01

Full Text Available In 2012 the National Library of Medicine awarded several academic medical libraries informationist grants to become embedded with a research team for the purposes of data management. The University of Rochester Medical Center was among those recipients. This article will give background on the research project and team that won the grant, discuss the process of applying for the grant, identify the data management role that the informationist librarians have agreed to work on, how they embedded into the research team, and relay lessons learned thus far in the project.

To Your Health: NLM update transcript - NIH MedlinePlus magazine Winter 2018

Science.gov (United States)

... who is a star of 'The Big Bang Theory' television show, and the producer/narrator of a ... trials, NIH MedlinePlus magazine reports the current life expectancy of a person with sickle cell disease is ...

Sequence Classification: 789801 [

Lifescience Database Archive (English)

Full Text Available ctivated Kinase, colocalized with Rac1/CED-10 and CDC-42 at hypodermal cell boundaries during embryo elongat...ion., colocalized with Rac1/CED-10 and CDC-42 at hypodermal cell boundaries during embryo elongation (63.5 kD) (pak-1) || http://www.ncbi.nlm.nih.gov/protein/25147910 ...

Sequence Classification: 789802 [

Lifescience Database Archive (English)

Full Text Available ctivated Kinase, colocalized with Rac1/CED-10 and CDC-42 at hypodermal cell boundaries during embryo elongat...ion., colocalized with Rac1/CED-10 and CDC-42 at hypodermal cell boundaries during embryo elongation (63.9 kD) (pak-1) || http://www.ncbi.nlm.nih.gov/protein/25147913 ...

Sequence Classification: 786855 [

Lifescience Database Archive (English)

Full Text Available ctivated Kinase, colocalized with Rac1/CED-10 and CDC-42 at hypodermal cell boundaries during embryo elongat...ion., colocalized with Rac1/CED-10 and CDC-42 at hypodermal cell boundaries during embryo elongation (63.9 kD) (pak-1) || http://www.ncbi.nlm.nih.gov/protein/25147913 ...

Sequence Classification: 786854 [

Lifescience Database Archive (English)

Full Text Available ctivated Kinase, colocalized with Rac1/CED-10 and CDC-42 at hypodermal cell boundaries during embryo elongat...ion., colocalized with Rac1/CED-10 and CDC-42 at hypodermal cell boundaries during embryo elongation (63.5 kD) (pak-1) || http://www.ncbi.nlm.nih.gov/protein/25147910 ...

Sequence Classification: 892128 [

Lifescience Database Archive (English)

Full Text Available e I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on... growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; Myo5p || http://www.ncbi.nlm.nih.gov/protein/6323756 ...

Mechanistic Insights to the Cytotoxicity of Amaryllidaceae Alkaloids

Czech Academy of Sciences Publication Activity Database

Nair, J. J.; Rárová, L.; Strnad, Miroslav; Bastida, J.; van Staden, J.

2015-01-01

Roč. 10, č. 1 (2015), s. 171-182 ISSN 1934-578X Grant - others:GA MŠk(CZ) ED0007/01/01 Program:ED Institutional support: RVO:61389030 Keywords : Alkaloid * Amaryllidaceae * Apoptosis Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 0.884, year: 2015 http://www.ncbi.nlm.nih.gov/pubmed/25920242

Oligonucleic Acid Drug List: monrd0022 [Oligonucleic Acid Drug Database[Archive

Lifescience Database Archive (English)

Full Text Available ration of eIF4E mRNA decreased in 13 of 19 cases. ... https://www.clinicaltrialsregister.eu/ctr-search/trial/20...10-022239-12/HU, https://www.clinicaltrialsregister.eu/ctr-search/trial/2010-022240-21/HU, https://www.ncbi.nlm.nih.gov/pubmed/27194579 ... P06730 4TPW

Sequence Classification: 891946 [

Lifescience Database Archive (English)

Full Text Available es to the cell periphery; mRNA is targeted to the bud via the mRNA transport system involving She2p; C-termi...nal portion of Tcb1p, Tcb2p and Tcb3p interact; Tcb3p || http://www.ncbi.nlm.nih.gov/protein/6323568 ...

Whole-Genome Sequences of an Aerobic Anoxygenic Phototroph, Blastomonas sp. Strain AAP53, Isolated from a Freshwater Desert Lake in Inner Mongolia, China

Czech Academy of Sciences Publication Activity Database

Zeng, Yonghui; Koblížek, Michal; Feng, F.; Liu, Y.; Wu, Z.; Jian, J.

2013-01-01

Roč. 1, č. 2 (2013) ISSN 2169-8287 R&D Projects: GA ČR GAP501/10/0221; GA MŠk(CZ) ED2.1.00/03.0110 Institutional support: RVO:61388971 Keywords : Blastomonas * Genome sequence Subject RIV: EE - Microbiology, Virology http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622956/

Sequence Classification: 768696 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|17554128|ref|NP_498099.1| the gene is express...ed protein retains C2H2 zinc-finger at its N-terminal region (162.6 kD) (3G269) || http://www.ncbi.nlm.nih.gov/protein/17554128 ...

Sequence Classification: 521551 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|51473447|ref|YP_067204.1| Alanine:alanine... ligase (ADP-forming).; Alanylalanine synthetase.; D-Ala-D-Ala synthetase.; D-alanine--D-alanine ligase; D-alanyl-D-alanine... synthetase.; D-alanylalanine synthetase. || http://www.ncbi.nlm.nih.gov/protein/51473447 ...

Stemcell Information: SKIP000191 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available 2848530--http://www.ncbi.nlm.nih.gov/pubmed/?term=23039195 -- 確定診断方法：スーパーコントロール|HIV : 実施　陰性|HTLV-1 : 未実施|HBV : 実施　陰性|HCV : 実施　陰性|病歴

Stemcell Information: SKIP000193 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available 2848530--http://www.ncbi.nlm.nih.gov/pubmed/?term=23039195 -- 確定診断方法：スーパーコントロール|HIV : 実施　陰性|HTLV-1 : 未実施|HBV : 実施　陰性|HCV : 実施　陰性|病歴

Defense Technical Information Center Free Text Experiment - Technical Report File.

Science.gov (United States)

1981-10-01

but also to minimize "no hits." For the purpose of this test the National Library of Medicine (NLM) Stop Word List (appendix D) was used as a basis for...Search @SRTAB@ black cats end 8. Synonyms should be considered as part of the search strategy: Example: MARIJUANA, MARIHUANA , POT, GRASS, WEED, MARY

Fellowship training at John Hopkins: programs leading to careers in librarianship and informatics as informaticians or informationists.

Science.gov (United States)

Campbell, Jayne M; Roderer, Nancy K

2005-01-01

Preparing librarians to meet the information challenges faced in the current and future health care environments is critical. At Johns Hopkins University, three NLM-funded fellowship programs provide opportunities for librarians to utilize the rich environments of the Welch Medical Library and the Division of Health Sciences Informatics in support of life-long learning.

Sequence Classification: 893652 [

Lifescience Database Archive (English)

Full Text Available pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses lead...ing to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor; Mf(alpha)1p || http://www.ncbi.nlm.nih.gov/protein/6325069 ...

Fracture Mechanics Method for Word Embedding Generation of Neural Probabilistic Linguistic Model

Directory of Open Access Journals (Sweden)

Size Bi

2016-01-01

Full Text Available Word embedding, a lexical vector representation generated via the neural linguistic model (NLM, is empirically demonstrated to be appropriate for improvement of the performance of traditional language model. However, the supreme dimensionality that is inherent in NLM contributes to the problems of hyperparameters and long-time training in modeling. Here, we propose a force-directed method to improve such problems for simplifying the generation of word embedding. In this framework, each word is assumed as a point in the real world; thus it can approximately simulate the physical movement following certain mechanics. To simulate the variation of meaning in phrases, we use the fracture mechanics to do the formation and breakdown of meaning combined by a 2-gram word group. With the experiments on the natural linguistic tasks of part-of-speech tagging, named entity recognition and semantic role labeling, the result demonstrated that the 2-dimensional word embedding can rival the word embeddings generated by classic NLMs, in terms of accuracy, recall, and text visualization.

Improving data collection, documentation, and workflow in a dementia screening study.

Science.gov (United States)

Read, Kevin B; LaPolla, Fred Willie Zametkin; Tolea, Magdalena I; Galvin, James E; Surkis, Alisa

2017-04-01

A clinical study team performing three multicultural dementia screening studies identified the need to improve data management practices and facilitate data sharing. A collaboration was initiated with librarians as part of the National Library of Medicine (NLM) informationist supplement program. The librarians identified areas for improvement in the studies' data collection, entry, and processing workflows. The librarians' role in this project was to meet needs expressed by the study team around improving data collection and processing workflows to increase study efficiency and ensure data quality. The librarians addressed the data collection, entry, and processing weaknesses through standardizing and renaming variables, creating an electronic data capture system using REDCap, and developing well-documented, reproducible data processing workflows. NLM informationist supplements provide librarians with valuable experience in collaborating with study teams to address their data needs. For this project, the librarians gained skills in project management, REDCap, and understanding of the challenges and specifics of a clinical research study. However, the time and effort required to provide targeted and intensive support for one study team was not scalable to the library's broader user community.

Effects of sequence on DNA wrapping around histones

Science.gov (United States)

Ortiz, Vanessa

2011-03-01

A central question in biophysics is whether the sequence of a DNA strand affects its mechanical properties. In epigenetics, these are thought to influence nucleosome positioning and gene expression. Theoretical and experimental attempts to answer this question have been hindered by an inability to directly resolve DNA structure and dynamics at the base-pair level. In our previous studies we used a detailed model of DNA to measure the effects of sequence on the stability of naked DNA under bending. Sequence was shown to influence DNA's ability to form kinks, which arise when certain motifs slide past others to form non-native contacts. Here, we have now included histone-DNA interactions to see if the results obtained for naked DNA are transferable to the problem of nucleosome positioning. Different DNA sequences interacting with the histone protein complex are studied, and their equilibrium and mechanical properties are compared among themselves and with the naked case. NLM training grant to the Computation and Informatics in Biology and Medicine Training Program (NLM T15LM007359).

Sequence Classification: 894094 [

Lifescience Database Archive (English)

Full Text Available n that forms heterodimers, with Msh3p and Msh6p, that bind to DNA mismatches to initiate the mismatch repair process; contains a Walk...er ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP; Msh2p || http://www.ncbi.nlm.nih.gov/protein/6324482 ...

Biotransformation of Silybin and its Congeners

Czech Academy of Sciences Publication Activity Database

Křen, Vladimír; Marhol, Petr; Purchartová, Kateřina; Gabrielová, E.; Modrianský, M.

2013-01-01

Roč. 14, č. 10 (2013), s. 1009-1021 ISSN 1389-2002 R&D Projects: GA ČR(CZ) GAP301/11/0662; GA MŠk(CZ) LD11051 Institutional support: RVO:61388971 Keywords : Biotransformation * cytochrome P450 * diastereoisomers Subject RIV: CE - Biochemistry Impact factor: 3.487, year: 2013 http://www.ncbi.nlm.nih.gov/pubmed/24261705

Sequence Classification: 768697 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|17554126|ref|NP_498100.1| the gene is express...ed protein retains C2H2 zinc-finger at its N-terminal region. family member (57.9 kD) (3G277) || http://www.ncbi.nlm.nih.gov/protein/17554126 ...

Glauber amplitudes for transitions from low lying states in hydrogen atom by charged particle impact

Energy Technology Data Exchange (ETDEWEB)

Kumar, S; Srivastava, M K [Roorkee Univ. (India). Dept. of Physics

1977-07-01

The Glauber amplitudes for the general transition nlm ..-->.. n'1'm' in charged particle - hydrogen atom collisions have been obtained in the form of a one-dimensional integral. The final expression involves only a few hypergeometric functions if n is not too large and is particularly suited to study excitation to highly excited states from a low lying state.

Natural postmenopause is associated with an increase in combined cardiovascular risk factors

Czech Academy of Sciences Publication Activity Database

Lejsková, M.; Alušík, Š.; Valenta, Zdeněk; Adámková, S.; Piťha, J.

2012-01-01

Roč. 61, č. 6 (2012), s. 587-596 ISSN 0862-8408 Grant - others:GA MZd(CZ) NS10511 Institutional research plan: CEZ:AV0Z10300504 Keywords : menopause * metabolic syndrome * dyslipidemia * cardiovascular disease * central obesity Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition Impact factor: 1.531, year: 2012 http://www.ncbi.nlm.nih.gov/pubmed/23098660

Sequence Classification: 893940 [

Lifescience Database Archive (English)

Full Text Available Non-TMB TMH TMB Non-TMB TMB Non-TMB >gi|6325380|ref|NP_015449.1| High-affinity copper... transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transc...riptionally induced at low copper levels and degraded at high copper levels; Ctr1p || http://www.ncbi.nlm.nih.gov/protein/6325380 ...

To Your Health: NLM update transcript - Why US diplomats in Cuba became ill

Science.gov (United States)

... eye movements. In addition, the study suggests severe hearing loss occurred among three of the 21 diplomats that ... study's three authors explain most of the impacted workers were motivated to return to work after a ...

To Your Health: NLM update transcript - Improving the international response to infectious illness

Science.gov (United States)

... data analysts to estimate and predict the eventual importance of the initial cases to public health that ... is authoritative. It's free. We do not accept advertising .... and is written to help you. To find ...

Sequence Classification: 390326 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|31794837|ref|NP_857330.1| ACETYL-COENZYME... A SYNTHETASE ACS (ACETATE--CoA LIGASE) (ACETYL-CoA SYNTHETASE) (ACETYL-CoA SYNTHASE) (ACYL-ACTIVATING ENZYME...) (ACETATE THIOKINASE) (ACETYL-ACTIVATING ENZYME) (ACETATE--COENZYME A LIGASE) (ACETYL-COENZYME A SYNTHASE) || http://www.ncbi.nlm.nih.gov/protein/31794837 ...

Sequence Classification: 400109 [

Lifescience Database Archive (English)

Full Text Available Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|15610803|ref|NP_218184.1| ACETYL-COENZYME... A SYNTHETASE ACS (ACETATE--CoA LIGASE) (ACETYL-CoA SYNTHETASE) (ACETYL-CoA SYNTHASE) (ACYL-ACTIVATING ENZYME...) (ACETATE THIOKINASE) (ACETYL-ACTIVATING ENZYME) (ACETATE--COENZYME A LIGASE) (ACETYL-COENZYME A SYNTHASE) || http://www.ncbi.nlm.nih.gov/protein/15610803 ...

Sequence Classification: 225448 [

Lifescience Database Archive (English)

Full Text Available genase iron molybdenum cofactor biosinthesis protein, nifK-nitrogenase molibdenum-i...ron protein beta chain, nifB-nitrogenase iron-molibdenum cofactor biosynthesis protein) || http://www.ncbi.nlm.nih.gov/protein/15893551 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|15893551|ref|NP_346900.1| Fusion nifN/K+nifB (nifN-nitro

Ameloblastin Peptides Modulates the Osteogenic Capacity of Human Mesenchymal Stem Cells

Czech Academy of Sciences Publication Activity Database

Stakkestad, O.; Lyngstadaas, S. P.; Vondrášek, Jiří; Gordeladze, J. O.; Reseland, J. E.

2017-01-01

Roč. 8, Feb 7 (2017), č. článku 58. ISSN 1664-042X Institutional support: RVO:61388963 Keywords : ameloblastin * biomineralization * bone growth * exon 5 * human mesenchymal stem cells * osteogenesis * proliferation Subject RIV: ED - Physiology OBOR OECD: Physiology (including cytology) Impact factor: 4.134, year: 2016 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293776/pdf/fphys-08-00058.pdf

Hardened Solar Array High Temperature Adhesive.

Science.gov (United States)

1981-04-01

SHERWOOO. D SASIU.IS F3361S-0-C-201S UNCLASSI ED 1AC-SCG-IOOIIR AFVAL-TR-OL-201? NLm,,hinii EhhhEE11I1 AFWAL-TR-81- 2017 i : HARDENED SOLAR ARRAY D HIGH...Tg and as a consequence forms a film on the container and also precipitates as tacky waxlike particles, rather than the desired flocullated

Use of the critical incident technique to evaluate the impact of MEDLINE

International Nuclear Information System (INIS)

Wilson, S.R.; Starr-Schneidkraut, N.; Cooper, M.D.

1989-01-01

The NLM has an ongoing responsibility to assess the extent to which its information products and services support the requirements of its users. This enables the Library to craft ever more responsive systems that capitalize on the latest advances in information and computer technology and, when necessary, to modify existing systems whose performance may no longer be optimal or consistent with the functions intended. The importance of this requirement was underscored in the recent report of the Outreach Planning Panel to the NLM Board of regents. A fundamental concern is the need to identify the impact of MEDLINE-derived information--i.e., does the use of MEDLINE ''make a difference''? In what ways is it used, and with what effect? In particular, is information retrieved from MEDLINE used successfully by health professionals to support medical decision-making and patient care? Previous efforts to address this question have been limited to the collection of available anecdotal reports. Traditional survey methodology, with pre-defined response categories, while used effectively to determine general areas in which MEDLINE information is used, is not well suited to developing a detailed understanding of user motivation, behavior, and resulting consequences. 8 refs., 6 figs., 2 tab

Momentum distributions: opening remarks

International Nuclear Information System (INIS)

Weigold, E.

1982-01-01

The problem of the hydrogen atom has played a central role in the development of quantum mechanics, beginning with Bohr's daring speculations. It was also the first problem tackled by Schroedinger with his new wave mechanics and similarly it was used by Heisenberg in his first papers as a prime example of the success of quantum mechanics. It has always played a central role in the teaching of quantum physics and has served as a most important heuristic tool, shaping our intuition and inspiring many expositions. The Schroedinger equation for the hydrogen atom is usually solved in the position representation, the solution to the equation being the wave functions psi/sub nlm/(r). If Schroedinger's equation is solved in the momentum representation instead of the coordinate representation, the absolute square of the corresponding momentum state wave function phi/sub nlm/(p) would give the momentum probability distribution of the electron in the state defined by the quantum numbers n, l and m. Three different types of collisions which can take place in the (e,2e) reaction on atomic hydrogen, which is a three body problem, are discussed

Desiderata for an authoritative Representation of MeSH in RDF.

Science.gov (United States)

Winnenburg, Rainer; Bodenreider, Olivier

2014-01-01

The Semantic Web provides a framework for the integration of resources on the web, which facilitates information integration and interoperability. RDF is the main representation format for Linked Open Data (LOD). However, datasets are not always made available in RDF by their producers and the Semantic Web community has had to convert some of these datasets to RDF in order for these datasets to participate in the LOD cloud. As a result, the LOD cloud sometimes contains outdated, partial and even inaccurate RDF datasets. We review the LOD landscape for one of these resources, MeSH, and analyze the characteristics of six existing representations in order to identify desirable features for an authoritative version, for which we create a prototype. We illustrate the suitability of this prototype on three common use cases. NLM intends to release an authoritative representation of MeSH in RDF (beta version) in the Fall of 2014.

Lost in translation: Defects in transfer RNA modifications and neurological disorders

Czech Academy of Sciences Publication Activity Database

Bednářová, Andrea; Hanna, M.; Durham, I.; Van Cleave, T.; England, A.; Chaudhuri, A.; Krishnan, N.

2017-01-01

Roč. 10, MAY 09 (2017), č. článku 135. ISSN 1662-5099 Grant - others:GA ČR(CZ) L200961701 Institutional support: RVO:60077344 Keywords : transfer RNA modifications * modified nucleosides * neurological disease Subject RIV: EB - Genetics ; Molecular Biology OBOR OECD: Genetics and heredity (medical genetics to be 3) Impact factor: 5.076, year: 2016 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422465/

A Randomized Controlled Trial of the Group-Based Modified Story Memory Technique in TBI

Science.gov (United States)

2017-10-01

major task was to coordinate the study staff for the clinical trial. This is also a time- consuming processing that involves hiring the appropriate...for improving NLM in individuals with Multiple Sclerosis (MS) and TBI across three realms of functioning, objective behavior , brain functioning and...improving new learning and memory in individuals with Multiple Sclerosis (MS) and TBI across three realms of functioning, objective behavior , brain

Sequence Classification: 893123 [

Lifescience Database Archive (English)

Full Text Available inal member of the mitochondrial inner membrane electron transport chain; predominantly express...ed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; Cox5ap || http://www.ncbi.nlm.nih.gov/protein/6324276 ... ...TMB TMH TMB TMB TMB TMB >gi|6324276|ref|NP_014346.1| Subunit Va of cytochrome c oxidase, which is the term

Assessment of physical activity of the human body considering the thermodynamic system

Czech Academy of Sciences Publication Activity Database

Hochstein, S.; Rauschenberger, P.; Weigand, B.; Siebert, T.; Schmitt, S.; Schlicht, W.; Převorovská, Světlana; Maršík, F.

2016-01-01

Roč. 19, č. 9 (2016), s. 923-933 ISSN 1025-5842 Institutional support: RVO:61388998 Keywords : physical activity * entropy * activity assessment Subject RIV: BJ - Thermodynamics Impact factor: 1.909, year: 2016 http://www.tandfonline.com/doi/abs/10.1080/10255842.2015.1076804?journalCode=gcmb20, http://dx.doi.org/10.1080/10255842.2015.1076804, http://www.ncbi.nlm.nih.gov/pubmed/26296149

U---------------------------------~-------------R-ES-ONANCE---ID-ec-ember ...

Indian Academy of Sciences (India)

The electron has a particle and a wave nature. Due to its wave nature, the electron in a stationary state of the Hydrogen atom is characterized by its wave function \\\\I nJm (r, 9, .). Here (r, 9, .) are the spherical polar coordinates, used to specify the position of the electron in space (see the figure) and n,l,m are the principal ...

Searches for the Standard Model Higgs boson at the Tevatron collider

Energy Technology Data Exchange (ETDEWEB)

Fisher, Wade C. [Michigan State Univ., East Lansing, MI (United States). Dept. of Physics and Astronomy; Junk, Thomas R. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

2016-01-01

During Run II of the Tevatron collider, which took place from 2001 until 2011, the CDF and D0 detectors each collected approximately 10 fb ^-1 of NLM_inline-graphic"> collision data at a center-of-mass energy of NLM_inline-graphic">. This dataset allowed for tests for the presence of the SM Higgs boson in the mass range 90-200 GeV in the production modes gg → H, W/ZH, vector-boson fusion, and NLM_inline-graphic">H, with H decay modes H → NLM_inline-graphic">, H → W⁺W^-, H → �

Sequence Classification: 889924 [

Lifescience Database Archive (English)

Full Text Available the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory protein...s through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p; Sss1p || http://www.ncbi.nlm.nih.gov/protein/6320291 ...

Improving data collection, documentation, and workflow in a dementia screening study

Directory of Open Access Journals (Sweden)

Kevin B. Read, MLIS, MAS

2017-04-01

Conclusions: NLM informationist supplements provide librarians with valuable experience in collaborating with study teams to address their data needs. For this project, the librarians gained skills in project management, REDCap, and understanding of the challenges and specifics of a clinical research study. However, the time and effort required to provide targeted and intensive support for one study team was not scalable to the library’s broader user community.

Bruxism: A Literature Review

OpenAIRE

Shetty, Shilpa; Pitti, Varun; Satish Babu, C. L.; Surendra Kumar, G. P.; Deepthi, B. C.

2010-01-01

Bruxism is a movement disorder characterized by grinding and clenching of teeth. Awake bruxism is found more in females as compared to males while sleep bruxism shows no such gender prevalence. Etiology of bruxism can be divided into three groups psychosocial factors, peripheral factors and pathophysiological factors. Treatment modalities involve occlusal correction, behavioural changes and pharmacological approach. A literature search was performed using National Library of Medicine’s (NLM) ...

GenBank

OpenAIRE

Benson, Dennis A.; Cavanaugh, Mark; Clark, Karen; Karsch-Mizrachi, Ilene; Lipman, David J.; Ostell, James; Sayers, Eric W.

2012-01-01

GenBank? (http://www.ncbi.nlm.nih.gov) is a comprehensive database that contains publicly available nucleotide sequences for almost 260 000 formally described species. These sequences are obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects, including whole-genome shotgun (WGS) and environmental sampling projects. Most submissions are made using the web-based BankIt or standalone Sequin programs, and GenBank staff assig...

Push-Broom-Type Very High-Resolution Satellite Sensor Data Correction Using Combined Wavelet-Fourier and Multiscale Non-Local Means Filtering

Science.gov (United States)

Kang, Wonseok; Yu, Soohwan; Seo, Doochun; Jeong, Jaeheon; Paik, Joonki

2015-01-01

In very high-resolution (VHR) push-broom-type satellite sensor data, both destriping and denoising methods have become chronic problems and attracted major research advances in the remote sensing fields. Since the estimation of the original image from a noisy input is an ill-posed problem, a simple noise removal algorithm cannot preserve the radiometric integrity of satellite data. To solve these problems, we present a novel method to correct VHR data acquired by a push-broom-type sensor by combining wavelet-Fourier and multiscale non-local means (NLM) filters. After the wavelet-Fourier filter separates the stripe noise from the mixed noise in the wavelet low- and selected high-frequency sub-bands, random noise is removed using the multiscale NLM filter in both low- and high-frequency sub-bands without loss of image detail. The performance of the proposed method is compared to various existing methods on a set of push-broom-type sensor data acquired by Korean Multi-Purpose Satellite 3 (KOMPSAT-3) with severe stripe and random noise, and the results of the proposed method show significantly improved enhancement results over existing state-of-the-art methods in terms of both qualitative and quantitative assessments. PMID:26378532

PET reconstruction via nonlocal means induced prior.

Science.gov (United States)

Hou, Qingfeng; Huang, Jing; Bian, Zhaoying; Chen, Wufan; Ma, Jianhua

2015-01-01

The traditional Bayesian priors for maximum a posteriori (MAP) reconstruction methods usually incorporate local neighborhood interactions that penalize large deviations in parameter estimates for adjacent pixels; therefore, only local pixel differences are utilized. This limits their abilities of penalizing the image roughness. To achieve high-quality PET image reconstruction, this study investigates a MAP reconstruction strategy by incorporating a nonlocal means induced (NLMi) prior (NLMi-MAP) which enables utilizing global similarity information of image. The present NLMi prior approximates the derivative of Gibbs energy function by an NLM filtering process. Specially, the NLMi prior is obtained by subtracting the current image estimation from its NLM filtered version and feeding the residual error back to the reconstruction filter to yield the new image estimation. We tested the present NLMi-MAP method with simulated and real PET datasets. Comparison studies with conventional filtered backprojection (FBP) and a few iterative reconstruction methods clearly demonstrate that the present NLMi-MAP method performs better in lowering noise, preserving image edge and in higher signal to noise ratio (SNR). Extensive experimental results show that the NLMi-MAP method outperforms the existing methods in terms of cross profile, noise reduction, SNR, root mean square error (RMSE) and correlation coefficient (CORR).

Tracking Color Shift in Ballpoint Pen Ink Using Photoshop Assisted Spectroscopy: A Nondestructive Technique Developed to Rehouse a Nobel Laureate's Manuscript

OpenAIRE

Wright, Kristi; Herro, Holly

2016-01-01

Many historically and culturally significant documents from the mid-to-late twentieth century were written in ballpoint pen inks, which contain light-sensitive dyes that present problems for collection custodians and paper conservators. The conservation staff at the National Library of Medicine (NLM), National Institutes of Health, conducted a multiphase project on the chemistry and aging of ballpoint pen ink that culminated in the development of a new method to detect aging of ballpoint pen ...

Dispositional employability and online training purchase. Evidence from employees' behavior in Spain

OpenAIRE

BOADA GRAU, JOAN; Joan Torrent-Sellens; Pilar Ficapal-Cusí

2016-01-01

DOI: 10.3389/fpsyg.2016.00831 URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887487/ Filiació URV: SI This article explores the relationship between dispositional employability and online training purchase. Through a sample of 883 employees working for enterprises in Spain, and a using principal component analysis and binomial logit probabilistic models, the research revealed two main results. First, it was found that dispositional employability is characterized by five factors: ...

Automatic bounding estimation in modified NLMS algorithm

International Nuclear Information System (INIS)

Shahtalebi, K.; Doost-Hoseini, A.M.

2002-01-01

Modified Normalized Least Mean Square algorithm, which is a sign form of Nlm based on set-membership (S M) theory in the class of optimal bounding ellipsoid (OBE) algorithms, requires a priori knowledge of error bounds that is unknown in most applications. In a special but popular case of measurement noise, a simple algorithm has been proposed. With some simulation examples the performance of algorithm is compared with Modified Normalized Least Mean Square

Health effects of toxicants: Online knowledge support

Science.gov (United States)

Judson, Richard; de Marcellus, Sally; de Knecht, Joop; Leinala, Eeva

2016-01-01

Research in toxicology generates vast quantities of data which reside on the Web and are subsequently appropriated and utilized to support further research. This data includes a broad spectrum of information about chemical, biological and radiological agents which can affect health, the nature of the effects, treatment, regulatory measures, and more. Information is structured in a variety of formats, including traditional databases, portals, prediction models, and decision making support tools. Online resources are created and housed by a variety of institutions, including libraries and government agencies. This paper focuses on three such institutions and the tools they offer to the public: the National Library of Medicine (NLM) and its Toxicology and Environmental Health Information Program, the United States Environmental Protection Agency (EPA), and the Organisation for Economic Co-operation and Development (OECD). Reference is also made to other relevant organizations. PMID:26506572

Efeitos do treino e do destreino sobre indicadores de força em jovens voleibolistas: implicações da distribuição do volume Training and detraining effects on strength parameters in young volleyball players: volume distribution implications

Directory of Open Access Journals (Sweden)

Mário C. Marques

2011-06-01

Full Text Available O objetivo do presente estudo foi comparar os efeitos do treino de força (TF e do respectivo destreinamento entre dois modelos de periodização do volume (linear - ML; não linear - MNL em jovens voleibolistas. A amostra foi composta por 12 jovens do sexo masculino jogadores de voleibol (17.1 ± 0.5 anos, divididos em dois grupos homogêneos. Os resultados sugerem que 8 semanas de TF induzem modificações significativas nos indicadores da força, independentemente do modelo de periodização utilizado. Contudo, o MNL parece menos eficaz no desenvolvimento da força explosiva em habilidades motoras específicas (salto vertical. Os resultados indicam que 4 semanas de destreinamento são suficientes para provocarem perdas significas na força muscular em jovens voleibolistas. O destreinamento de um ML induz a perdas significativas na força explosiva do trem superior (lançamento de bola medicinal e inferior (salto vertical, enquanto que no MNL parece diminuir significativamente a força dinâmica máxima (supino e o desempenho no salto vertical.This study aimed to compare the effects of strength training (ST and detraining (DT of two volume periodization models (linear - LM; non linear - NLM in young male volleyball players. 12 volleyball players (17.1±0.5 years old were randomly divided into two groups. The results of the present study suggest that 8 weeks of ST induce changes in the indicators of increased maximal strength and explosive strength, regardless of models used. However, the NLM seems less effective in the development of explosive strength in specific motor skills (vertical jump. As for DT, this study suggests that 4 weeks is sufficient to cause significant losses as an indicator of release between the two models of training. The LM induces significant losses in the explosive strength of the upper (medicine ball throwing and lower body (vertical jump, while the NLM suggests higher losses in the maximum strength (train top besides

Behavior problems and prevalence of asthma symptoms among Brazilian children

OpenAIRE

Feitosa, Caroline Alves; Santos, Darci N.; Carmo, Maria Beatriz Barreto do; Santos, Letícia Marques dos; Teles, Carlos A. S.; Rodrigues, Laura C.; Barreto, Mauricio Lima

2011-01-01

Acesso ao resumo: http://www.ncbi.nlm.nih.gov/pubmed/21843751 Objective: Asthma is the most common chronic disease in childhood and has been designated a public health problem due to the increase in its prevalence in recent decades, the amount of health service expenditure it absorbs and an absence of consensus about its etiology. The relationships among psychosocial factors and the occurrence, symptomatology, and severity of asthma have recently been considered. There is still controversy...

Secondary structure and feature of mitochondrial tRNA genes of the Ussurian tube-nosed bat Murina ussuriensis (Chiroptera: Vespertilionidae

Directory of Open Access Journals (Sweden)

Kwang Bae Yoon

2015-09-01

Full Text Available The complete mitogenome (NC_021119 of the Ussurian tube-nosed bat Murina ussuriensis (Chiroptera: Vespertilionidae was annotated and characterized in our recent publication (http://www.ncbi.nlm.nih.gov/nuccore/NC_021119. Here we provide additional information on methods in detail for obtaining the complete sequence of M. ussuriensis mitogenome. In addition, we describe characteristics of 22 tRNA genes and secondary structure and feature of 22 tRNAs of M. ussuriensis mitogenome.

Neuroendocrine liver metastases: Vascular patterns on triple-phase MDCT are indicative of primary tumour location

Energy Technology Data Exchange (ETDEWEB)

Ronot, Maxime, E-mail: maxime.ronot@aphp.fr [Department of Radiology, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, Hauts-de-Seine (France); University Paris Diderot, Sorbonne Paris Cité, Paris (France); INSERM U1149, centre de recherche biomédicale Bichat-Beaujon, CRB3, Paris (France); Cuccioli, Francesco; Dioguardi Burgio, Marco; Vullierme, Marie-Pierre [Department of Radiology, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, Hauts-de-Seine (France); Hentic, Olivia [Department of Pancreatology, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, Hauts-de-Seine (France); Ruszniewski, Philippe [University Paris Diderot, Sorbonne Paris Cité, Paris (France); Department of Pancreatology, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, Hauts-de-Seine (France); D’Assignies, Gaspard [Department of Radiology, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, Hauts-de-Seine (France); Vilgrain, Valérie [Department of Radiology, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, Hauts-de-Seine (France); University Paris Diderot, Sorbonne Paris Cité, Paris (France); INSERM U1149, centre de recherche biomédicale Bichat-Beaujon, CRB3, Paris (France)

2017-04-15

Purpose: To re-evaluate and compare CT features of neuroendocrine liver metastases (NLM) from pancreatic (p) and enteric (e) gastroenteropancreatic (GEP) tumours. Material and methods: From 2006–2013, all patients with proven GEP-neuroendocrine tumours (NETs) with at least one NLM, no previous treatment were included. On unenhanced, arterial and portal phases, NLMs were characterized as hypo-, iso- or hyperattenuating in consensus by 2 radiologists blinded to clinical data. Enhancement patterns (EP) corresponded to the combination of arterial/portal CT attenuation. Results: 78 patients (43 men, 55%, mean 56 ± 13 yo) and 559 NLMs were analyzed. pNLMs were more frequently hypoattenuating on unenhanced CT than eNLMs (72% vs. 57%, p < 0.001). 70% of the lesions were hypervascular with no significant difference between pNLMs and eNLMs (p = 0.32). eNLMs were more frequently hypoattenuating on portal phase than pNLMs (88% vs. 56%, p < 0.001). eNLMs were more frequently hyper/hypo than pNLMs (56% vs. 28%, p < 0.001). pNLMs were more frequently hyper/iso than eNLMs (33% vs. 8%, p < 0.001). Other NLMs showed various patterns, including hypo/hypo in 12%. Conclusion: Most NLMs of GEP tumours are hypervascular but the enhancement pattern on multiphasic CT depends on the primary tumour. These differences are helpful when the primary tumour has not been diagnosed.

Improving face image extraction by using deep learning technique

Science.gov (United States)

Xue, Zhiyun; Antani, Sameer; Long, L. R.; Demner-Fushman, Dina; Thoma, George R.

2016-03-01

The National Library of Medicine (NLM) has made a collection of over a 1.2 million research articles containing 3.2 million figure images searchable using the Open-iSM multimodal (text+image) search engine. Many images are visible light photographs, some of which are images containing faces ("face images"). Some of these face images are acquired in unconstrained settings, while others are studio photos. To extract the face regions in the images, we first applied one of the most widely-used face detectors, a pre-trained Viola-Jones detector implemented in Matlab and OpenCV. The Viola-Jones detector was trained for unconstrained face image detection, but the results for the NLM database included many false positives, which resulted in a very low precision. To improve this performance, we applied a deep learning technique, which reduced the number of false positives and as a result, the detection precision was improved significantly. (For example, the classification accuracy for identifying whether the face regions output by this Viola- Jones detector are true positives or not in a test set is about 96%.) By combining these two techniques (Viola-Jones and deep learning) we were able to increase the system precision considerably, while avoiding the need to manually construct a large training set by manual delineation of the face regions.

De novo transcriptome assembly of two contrasting pumpkin cultivars

Directory of Open Access Journals (Sweden)

Aliki Xanthopoulou

2016-03-01

Full Text Available Cucurbita pepo (squash, pumpkin, gourd, a worldwide-cultivated vegetable of American origin, is extremely variable in fruit characteristics. However, the information associated with genes and genetic markers for pumpkin is very limited. In order to identify new genes and to develop genetic markers, we performed a transcriptome analysis (RNA-Seq of two contrasting pumpkin cultivars. Leaves and female flowers of cultivars, ‘Big Moose’ with large round fruits and ‘Munchkin’ with small round fruits, were harvested for total RNA extraction. We obtained a total of 6 GB (Big Moose; http://www.ncbi.nlm.nih.gov/Traces/sra/?run=SRR3056882 and 5 GB (Munchkin; http://www.ncbi.nlm.nih.gov/Traces/sra/?run=SRR3056883 sequence data (NCBI SRA database SRX1502732 and SRX1502735, respectively, which correspond to 18,055,786 and 14,824,292 150-base reads. After quality assessment, the clean sequences where 17,995,932 and 14,774,486 respectively. The numbers of total transcripts for ‘Big Moose’ and ‘Munchkin’ were 84,727 and 68,051, respectively. TransDecoder identified possible coding regions in assembled transcripts. This study provides transcriptome data for two contrasting pumpkin cultivars, which might be useful for genetic marker development and comparative transcriptome analyses. Keywords: RNA-Seq, Pumpkin, Contrasting cultivars, Cucurbita pepo

Global information infrastructure.

Science.gov (United States)

Lindberg, D A

1994-01-01

The High Performance Computing and Communications Program (HPCC) is a multiagency federal initiative under the leadership of the White House Office of Science and Technology Policy, established by the High Performance Computing Act of 1991. It has been assigned a critical role in supporting the international collaboration essential to science and to health care. Goals of the HPCC are to extend USA leadership in high performance computing and networking technologies; to improve technology transfer for economic competitiveness, education, and national security; and to provide a key part of the foundation for the National Information Infrastructure. The first component of the National Institutes of Health to participate in the HPCC, the National Library of Medicine (NLM), recently issued a solicitation for proposals to address a range of issues, from privacy to 'testbed' networks, 'virtual reality,' and more. These efforts will build upon the NLM's extensive outreach program and other initiatives, including the Unified Medical Language System (UMLS), MEDLARS, and Grateful Med. New Internet search tools are emerging, such as Gopher and 'Knowbots'. Medicine will succeed in developing future intelligent agents to assist in utilizing computer networks. Our ability to serve patients is so often restricted by lack of information and knowledge at the time and place of medical decision-making. The new technologies, properly employed, will also greatly enhance our ability to serve the patient.

Spiking cortical model based non-local means method for despeckling multiframe optical coherence tomography data

Science.gov (United States)

Gu, Yameng; Zhang, Xuming

2017-05-01

Optical coherence tomography (OCT) images are severely degraded by speckle noise. Existing methods for despeckling multiframe OCT data cannot deliver sufficient speckle suppression while preserving image details well. To address this problem, the spiking cortical model (SCM) based non-local means (NLM) method has been proposed in this letter. In the proposed method, the considered frame and two neighboring frames are input into three SCMs to generate the temporal series of pulse outputs. The normalized moment of inertia (NMI) of the considered patches in the pulse outputs is extracted to represent the rotational and scaling invariant features of the corresponding patches in each frame. The pixel similarity is computed based on the Euclidean distance between the NMI features and used as the weight. Each pixel in the considered frame is restored by the weighted averaging of all pixels in the pre-defined search window in the three frames. Experiments on the real multiframe OCT data of the pig eye demonstrate the advantage of the proposed method over the frame averaging method, the multiscale sparsity based tomographic denoising method, the wavelet-based method and the traditional NLM method in terms of visual inspection and objective metrics such as signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), equivalent number of looks (ENL) and cross-correlation (XCOR).

Consensus coding sequence (CCDS) database: a standardized set of human and mouse protein-coding regions supported by expert curation.

Science.gov (United States)

Pujar, Shashikant; O'Leary, Nuala A; Farrell, Catherine M; Loveland, Jane E; Mudge, Jonathan M; Wallin, Craig; Girón, Carlos G; Diekhans, Mark; Barnes, If; Bennett, Ruth; Berry, Andrew E; Cox, Eric; Davidson, Claire; Goldfarb, Tamara; Gonzalez, Jose M; Hunt, Toby; Jackson, John; Joardar, Vinita; Kay, Mike P; Kodali, Vamsi K; Martin, Fergal J; McAndrews, Monica; McGarvey, Kelly M; Murphy, Michael; Rajput, Bhanu; Rangwala, Sanjida H; Riddick, Lillian D; Seal, Ruth L; Suner, Marie-Marthe; Webb, David; Zhu, Sophia; Aken, Bronwen L; Bruford, Elspeth A; Bult, Carol J; Frankish, Adam; Murphy, Terence; Pruitt, Kim D

2018-01-04

The Consensus Coding Sequence (CCDS) project provides a dataset of protein-coding regions that are identically annotated on the human and mouse reference genome assembly in genome annotations produced independently by NCBI and the Ensembl group at EMBL-EBI. This dataset is the product of an international collaboration that includes NCBI, Ensembl, HUGO Gene Nomenclature Committee, Mouse Genome Informatics and University of California, Santa Cruz. Identically annotated coding regions, which are generated using an automated pipeline and pass multiple quality assurance checks, are assigned a stable and tracked identifier (CCDS ID). Additionally, coordinated manual review by expert curators from the CCDS collaboration helps in maintaining the integrity and high quality of the dataset. The CCDS data are available through an interactive web page (https://www.ncbi.nlm.nih.gov/CCDS/CcdsBrowse.cgi) and an FTP site (ftp://ftp.ncbi.nlm.nih.gov/pub/CCDS/). In this paper, we outline the ongoing work, growth and stability of the CCDS dataset and provide updates on new collaboration members and new features added to the CCDS user interface. We also present expert curation scenarios, with specific examples highlighting the importance of an accurate reference genome assembly and the crucial role played by input from the research community. Published by Oxford University Press on behalf of Nucleic Acids Research 2017.

The NLM evaluation lecture series: introduction to the special section on evaluating health communication programs.

Science.gov (United States)

Logan, Robert A; Kreps, Gary L

2014-12-01

This article introduces the Journal of Health Communication's special section, Evaluating Health Communication Programs. This special section is based on a public lecture series supported by the National Library of Medicine titled "Better Health: Evaluating Health Communication Programs" designed to share best practices for using evaluation research to develop, implement, refine, and institutionalize the best health communication programs for promoting public health. This introduction provides an overview to the series, summarizes the major presentations in the series, and describe implications from the series for translational health communication research, interventions, and programs that can enhance health outcomes.

口内法X線フィルムの臨床的評価

OpenAIRE

島田, 敏尚; 大坊, 元二; 鈴木, 陽典; 熊澤, 友子; 寺田, 秀雄; 高橋, 和裕; シマダ, トシナオ; ダイボウ, モトジ; スズキ, ヨウスケ; クマザワ, トモコ; テラダ, ヒデオ; タカハシ, カズヒロ; Toshinao, SHIMADA; Motoji, DAIBOU; Yousuke, SUZUKI

2003-01-01

In the present study, we investigated the diagnostic ability of AGFA dental film (A) compared with INSIGHT dental film (I), depending on the basic photograph characteristic test. The results were as follows : 1. The diagnostic point of the x-ray photograph focused on the structures of the dental root area. 2. The judging standard of the X-ray nlm reading confirmed because the contrast is a main factor. 3. The INSIGHT film was more acceptable that the photographic contrast was seen clearly on ...

A Methodology for Examining Collateral Effects on Military Operations during a Chemical, Biological, Radiological, and/or Nuclear Attack - Operational Effectiveness Loss Multiplier (OELM)

Science.gov (United States)

2015-04-01

nr 7.0% 35.8% Vomiting 10.9% 1.5% 4.4% Nr nr 5% 2.0% nr 2.0% Note: nr – not reported. Sources: a S. L. Andersen et al., “Successful Double...http://www.ncbi.nlm.nih.gov/pubmed/9182474. c James D. Arthur et al., “A Comparative Study of Gastrointestinal Infections in United States Soldiers...Recent Military Experience with Malaria Chemoprophylaxis,” 448; S. L. Andersen et al., “Successful Double-Blinded, Randomized, Placebo-Controlled Field

U. S. Naval Forces, Vietnam Monthly Historical Summary for May 1966

Science.gov (United States)

1966-07-06

Nlvm and Unit 27. nt Nlm Trnnp;. Tliey will bo undor CUMINf/.C for administrativo pm’poses. Harbor defense units in the II, III, and IV Corps...beach to investigate. In the process an explosion, possibly a small mine, occurred thirty yards astern of PCF 36, At the same time the Viet Cong...general climate throughout the month remained one of uncertainty, with most of ticers adopting a "wait and see" attitude. As a result the process of

Health effects of toxicants: Online knowledge support.

Science.gov (United States)

Wexler, Philip; Judson, Richard; de Marcellus, Sally; de Knecht, Joop; Leinala, Eeva

2016-01-15

Research in toxicology generates vast quantities of data which reside on the Web and are subsequently appropriated and utilized to support further research. This data includes a broad spectrum of information about chemical, biological and radiological agents which can affect health, the nature of the effects, treatment, regulatory measures, and more. Information is structured in a variety of formats, including traditional databases, portals, prediction models, and decision making support tools. Online resources are created and housed by a variety of institutions, including libraries and government agencies. This paper focuses on three such institutions and the tools they offer to the public: the National Library of Medicine (NLM) and its Toxicology and Environmental Health Information Program, the United States Environmental Protection Agency (EPA), and the Organisation for Economic Co-operation and Development (OECD). Reference is also made to other relevant organizations. Published by Elsevier Inc.

Genotyping-by-sequencing data of 272 crested wheatgrass (Agropyron cristatum genotypes

Directory of Open Access Journals (Sweden)

Pingchuan Li

2017-12-01

Full Text Available Crested wheatgrass [Agropyron cristatum L. (Gaertn.] is an important cool-season forage grass widely used for early spring grazing. However, the genomic resources for this non-model plant are still lacking. Our goal was to generate the first set of next generation sequencing data using the genotyping-by-sequencing technique. A total of 272 crested wheatgrass plants representing seven breeding lines, five cultivars and five geographically diverse accessions were sequenced with an Illumina MiSeq instrument. These sequence datasets were processed using different bioinformatics tools to generate contigs for diploid and tetraploid plants and SNPs for diploid plants. Together, these genomic resources form a fundamental basis for genomic studies of crested wheatgrass and other wheatgrass species. The raw reads were deposited into Sequence Read Archive (SRA database under NCBI accession SRP115373 (https://www.ncbi.nlm.nih.gov/sra?term=SRP115373 and the supplementary datasets are accessible in Figshare (10.6084/m9.figshare.5345092. Keywords: Crested wheatgrass, Genotyping-by-sequencing, Diploid, Tetraploid, Raw sequence data

Estimating small-scale roughness of a rock joint using TLS data

Science.gov (United States)

Bitenc, Maja; Kieffer, D. Scott; Khoshelham, Kourosh

2016-04-01

) is approximately normal. Standard deviation of differences on average slightly increases with the noise level, but is strongly dependent on the analysis direction. As proved by different researches within the field of signal, image and also TLS data processing, noise can be, to a certain extent, removed by a post-processing step called denoising. In this research, four denoising methods, namely discrete WT (DWT) and stationary WT (SWT), and classic NLM (NLM) and probabilistic NLM (PNLM), were used on noisy ATOS data. Results were compared based on the (i) height and (ii) roughness differences between denoised surfaces and reference ATOS surface, (iii) the peak signal-to-noise ratio (PSNR) and (iv) the visual check of denoised surface. Increased PSNRs and reduced roughness differences prove the importance of the TLS data denoising procedure. In case of SWT, NLM and PNLM the surface is mostly over smoothed, whereas in case of DWT some noise remains. References: - Grasselli, G. (2001). Shear strength of rock joints based on quantified surface description. École Polytechnique Fédérale de Lausanne. Lausanne, EPFL. - Sturzenegger, M. and D. Stead (2009). "Close-range terrestrial digital photogrammetry and terrestrial laser scanning for discontinuity characterization on rock cuts." Engineering Geology 106(3-4): 163-182.

All-optical conversion scheme from binary to its MTN form with the help of nonlinear material based tree-net architecture

Science.gov (United States)

Maiti, Anup Kumar; Nath Roy, Jitendra; Mukhopadhyay, Sourangshu

2007-08-01

In the field of optical computing and parallel information processing, several number systems have been used for different arithmetic and algebraic operations. Therefore an efficient conversion scheme from one number system to another is very important. Modified trinary number (MTN) has already taken a significant role towards carry and borrow free arithmetic operations. In this communication, we propose a tree-net architecture based all optical conversion scheme from binary number to its MTN form. Optical switch using nonlinear material (NLM) plays an important role.

Oligonucleic Acid Drug List: monrd0025 [Oligonucleic Acid Drug Database[Archive

Lifescience Database Archive (English)

Full Text Available com/kynamro-drug.htm, http://www.kegg.jp/dbget-bin/www_bget?D08946, https://www.clinicaltrialsregister.eu/ct...r-search/trial/2004-003934-32/DE, https://www.clinicaltrialsregister.eu/ctr-searc...h/trial/2005-003449-15/GB, http://www.ncbi.nlm.nih.gov/pubmed/21210756 https://www.clinicaltrialsregister.eu.../ctr-search/trial/2005-003450-10/GB, https://www.clinicaltrialsregister.eu/ctr-search/trial/2007-005140-24/N...L, https://www.clinicaltrialsregister.eu/ctr-search/trial/2011-001480-42/ES, https://www.clinicaltrialsreg

Modeling route choice criteria from home to major streets: A discrete choice approach

Directory of Open Access Journals (Sweden)

Jose Osiris Vidana-Bencomo

2018-03-01

Full Text Available A discrete choice model that consists of three sub-models was developed to investigates the route choice criteria of drivers who travel from their homes in the morning to the access point along the major streets that bound the Traffic Analysis Zones (TAZs. The first sub-model is a Nested Logit Model (NLM that estimates the probability of a driver has or has no multiple routes, and if the driver has multiple routes, the route selection criteria are based on the access point’s intersection control type or other factors. The second sub-model is a Mixed Logit (MXL model. It estimates the probabilities of the type of intersection control preferred by a driver. The third sub-model is a NLM that estimates the probabilities of a driver selecting his/her route for its shortest travel time or to avoid pedestrian, and if the aim is to take the fastest route, the decision criteria is based on the shortest distance or minimum stops and turns. Data gathered in a questionnaire survey were used to estimate the sub-models. The attributes of the utility functions of the sub-models are the driver’s demographic and trip characteristics. The model provides a means for transportation planners to distribute the total number of home-based trips generated within a TAZ to the access points along the major streets that bound the TAZ.

Patch-based anisotropic diffusion scheme for fluorescence diffuse optical tomography—part 1: technical principles

International Nuclear Information System (INIS)

Correia, Teresa; Arridge, Simon

2016-01-01

Fluorescence diffuse optical tomography (fDOT) provides 3D images of fluorescence distributions in biological tissue, which represent molecular and cellular processes. The image reconstruction problem is highly ill-posed and requires regularisation techniques to stabilise and find meaningful solutions. Quadratic regularisation tends to either oversmooth or generate very noisy reconstructions, depending on the regularisation strength. Edge preserving methods, such as anisotropic diffusion regularisation (AD), can preserve important features in the fluorescence image and smooth out noise. However, AD has limited ability to distinguish an edge from noise. In this two-part paper, we propose a patch-based anisotropic diffusion regularisation (PAD), where regularisation strength is determined by a weighted average according to the similarity between patches around voxels within a search window, instead of a simple local neighbourhood strategy. However, this method has higher computational complexity and, hence, we wavelet compress the patches (PAD-WT) to speed it up, while simultaneously taking advantage of the denoising properties of wavelet thresholding. The proposed method combines the nonlocal means (NLM), AD and wavelet shrinkage methods, which are image processing methods. Therefore, in this first paper, we used a denoising test problem to analyse the performance of the new method. Our results show that the proposed PAD-WT method provides better results than the AD or NLM methods alone. The efficacy of the method for fDOT image reconstruction problem is evaluated in part 2. (paper)

HARDI denoising using nonlocal means on S2

Science.gov (United States)

Kuurstra, Alan; Dolui, Sudipto; Michailovich, Oleg

2012-02-01

Diffusion MRI (dMRI) is a unique imaging modality for in vivo delineation of the anatomical structure of white matter in the brain. In particular, high angular resolution diffusion imaging (HARDI) is a specific instance of dMRI which is known to excel in detection of multiple neural fibers within a single voxel. Unfortunately, the angular resolution of HARDI is known to be inversely proportional to SNR, which makes the problem of denoising of HARDI data be of particular practical importance. Since HARDI signals are effectively band-limited, denoising can be accomplished by means of linear filtering. However, the spatial dependency of diffusivity in brain tissue makes it impossible to find a single set of linear filter parameters which is optimal for all types of diffusion signals. Hence, adaptive filtering is required. In this paper, we propose a new type of non-local means (NLM) filtering which possesses the required adaptivity property. As opposed to similar methods in the field, however, the proposed NLM filtering is applied in the spherical domain of spatial orientations. Moreover, the filter uses an original definition of adaptive weights, which are designed to be invariant to both spatial rotations as well as to a particular sampling scheme in use. As well, we provide a detailed description of the proposed filtering procedure, its efficient implementation, as well as experimental results with synthetic data. We demonstrate that our filter has substantially better adaptivity as compared to a number of alternative methods.

Genome-wide expression analysis comparing hypertrophic changes in normal and dysferlinopathy mice

Directory of Open Access Journals (Sweden)

Yun-Sil Lee

2015-12-01

Full Text Available Because myostatin normally limits skeletal muscle growth, there are extensive efforts to develop myostatin inhibitors for clinical use. One potential concern is that in muscle degenerative diseases, inducing hypertrophy may increase stress on dystrophic fibers. Our study shows that blocking this pathway in dysferlin deficient mice results in early improvement in histopathology but ultimately accelerates muscle degeneration. Hence, benefits of this approach should be weighed against these potential detrimental effects. Here, we present detailed experimental methods and analysis for the gene expression profiling described in our recently published study in Human Molecular Genetics (Lee et al., 2015. Our data sets have been deposited in the Gene Expression Omnibus (GEO database (GSE62945 and are available at http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE62945. Our data provide a resource for exploring molecular mechanisms that are related to hypertrophy-induced, accelerated muscular degeneration in dysferlinopathy.

NIHSeniorHealth: a free tool for online health information for older adults.

Science.gov (United States)

Linares, Brenda M

2013-01-01

NIHSeniorHealth is a free, consumer health website that covers health topics affecting older adults. The website was created and is maintained by the National Library of Medicine (NLM) and features more than 55 health topics and nearly 150 videos. The easy-to-use navigational and visual tools create a user-friendly experience for older adults, their families, and caregivers who seek senior-specific information on the web. This column will include an overview of the website, a simple search, and a review of the features of NIHSeniorHealth.

Hairy ears; Revisited

Directory of Open Access Journals (Sweden)

Daifullah Al Aboud

2014-04-01

Full Text Available Hair can grow in areas which are not usually hairy in human skin. The Online Mendelian Inheritance in Man (OMIM (http:// www.ncbi.nlm.nih.gov/omimhave some entries in this regards. These include ( %139600 – HAIRY ELBOWS, #605130 – HAIRY ELBOWS, SHORT STATURE, FACIAL DYSMORPHISM, AND DEVELOPMENTAL DELAY, 139630 – HAIRY NOSE TIP, 139500 – HAIRY EARS, and 425500 – HAIRY EARS, Y-LINKED. Hairy ears, (Fig. 1, are uncommon trait and it is rare to see a person with very long hair on the ears.

NCBI Bookshelf: books and documents in life sciences and health care.

Science.gov (United States)

Hoeppner, Marilu A

2013-01-01

Bookshelf (http://www.ncbi.nlm.nih.gov/books/) is a full-text electronic literature resource of books and documents in life sciences and health care at the National Center for Biotechnology Information (NCBI). Created in 1999 with a single book as an encyclopedic reference for resources such as PubMed and GenBank, it has grown to its current size of >1300 titles. Unlike other NCBI databases, such as GenBank and Gene, which have a strict data structure, books come in all forms; they are diverse in publication types, formats, sizes and authoring models. The Bookshelf data format is XML tagged in the NCBI Book DTD (Document Type Definition), modeled after the National Library of Medicine journal article DTDs. The book DTD has been used for systematically tagging the diverse data formats of books, a move that has set the foundation for the growth of this resource. Books at NCBI followed the route of journal articles in the PubMed Central project, using the PubMed Central architectural framework, workflows and processes. Through integration with other NCBI molecular databases, books at NCBI can be used to provide reference information for biological data and facilitate its discovery. This article describes Bookshelf at NCBI: its growth, data handling and retrieval and integration with molecular databases.

Performance evaluation of image denoising developed using convolutional denoising autoencoders in chest radiography

Science.gov (United States)

Lee, Donghoon; Choi, Sunghoon; Kim, Hee-Joung

2018-03-01

When processing medical images, image denoising is an important pre-processing step. Various image denoising algorithms have been developed in the past few decades. Recently, image denoising using the deep learning method has shown excellent performance compared to conventional image denoising algorithms. In this study, we introduce an image denoising technique based on a convolutional denoising autoencoder (CDAE) and evaluate clinical applications by comparing existing image denoising algorithms. We train the proposed CDAE model using 3000 chest radiograms training data. To evaluate the performance of the developed CDAE model, we compare it with conventional denoising algorithms including median filter, total variation (TV) minimization, and non-local mean (NLM) algorithms. Furthermore, to verify the clinical effectiveness of the developed denoising model with CDAE, we investigate the performance of the developed denoising algorithm on chest radiograms acquired from real patients. The results demonstrate that the proposed denoising algorithm developed using CDAE achieves a superior noise-reduction effect in chest radiograms compared to TV minimization and NLM algorithms, which are state-of-the-art algorithms for image noise reduction. For example, the peak signal-to-noise ratio and structure similarity index measure of CDAE were at least 10% higher compared to conventional denoising algorithms. In conclusion, the image denoising algorithm developed using CDAE effectively eliminated noise without loss of information on anatomical structures in chest radiograms. It is expected that the proposed denoising algorithm developed using CDAE will be effective for medical images with microscopic anatomical structures, such as terminal bronchioles.

Photoshop® Assisted Spectroscopy: An Economical and Non-Destructive Method for Tracking Color Shift.

Science.gov (United States)

Wright, Kristi; Herro, Holly

Many historically and culturally significant objects from the mid-to-late 20 th century were created with media which contains light sensitive dyes that present problems for collection custodians and conservators. The conservation staff at the National Library of Medicine (NLM), National Institutes of Health, conducted a multi-phase project on the aging of ballpoint pen ink in a variety of enclosure types that ultimately culminated in the development of a new method to detect color shift in documents with light sensitive media. This article offers instructions on how to detect color shift in digitized materials using Photoshop® Assisted Spectroscopy.

Osteoarthritis year in review 2016

DEFF Research Database (Denmark)

Boesen, M; Ellegaard, K; Henriksen, M

2017-01-01

PURPOSE: The current narrative review covers original research related to imaging in osteoarthritis (OA) in humans published in English between April 1st 2015 and March 31st 2016, in peer reviewed journals available in Medline via PubMed (http://www.ncbi.nlm.nih.gov/pubmed/). METHODS: Relevant...... compared to studies reported previous years is presented, followed by a review of selected imaging studies of primarily knee, hip and hand OA focussing on (1) results for detection of OA and OA-related pathology (2) studies dealing with treatments and (3) studies focussing on prognosis of disease...

Technology Opens Doors to Scientific Discovery, Portrait Unveiled of Former NLM Director Lindberg | NIH MedlinePlus the ...

Science.gov (United States)

... version of this page please turn JavaScript on. Technology Opens Doors to Scientific Discovery Past Issues / Spring 2016 Table of Contents Susannah Fox, chief technology officer of the U.S. Department of Health and ...

Brain transcriptomes of honey bees (Apis mellifera experimentally infected by two pathogens: Black queen cell virus and Nosema ceranae

Directory of Open Access Journals (Sweden)

Vincent Doublet

2016-12-01

Full Text Available Regulation of gene expression in the brain plays an important role in behavioral plasticity and decision making in response to external stimuli. However, both can be severely affected by environmental factors, such as parasites and pathogens. In honey bees, the emergence and re-emergence of pathogens and potential for pathogen co-infection and interaction have been suggested as major components that significantly impaired social behavior and survival. To understand how the honey bee is affected and responds to interacting pathogens, we co-infected workers with two prevalent pathogens of different nature, the positive single strand RNA virus Black queen cell virus (BQCV, and the Microsporidia Nosema ceranae, and explored gene expression changes in brains upon single infections and co-infections. Our data provide an important resource for research on honey bee diseases, and more generally on insect host-pathogen and pathogen-pathogen interactions. Raw and processed data are publicly available in the NCBI/GEO database: (http://www.ncbi.nlm.nih.gov/geo/ under accession number GSE81664.

Improving taxonomic accuracy for fungi in public sequence databases: applying ‘one name one species’ in well-defined genera with Trichoderma/Hypocrea as a test case

Science.gov (United States)

Strope, Pooja K; Chaverri, Priscila; Gazis, Romina; Ciufo, Stacy; Domrachev, Michael; Schoch, Conrad L

2017-01-01

Abstract The ITS (nuclear ribosomal internal transcribed spacer) RefSeq database at the National Center for Biotechnology Information (NCBI) is dedicated to the clear association between name, specimen and sequence data. This database is focused on sequences obtained from type material stored in public collections. While the initial ITS sequence curation effort together with numerous fungal taxonomy experts attempted to cover as many orders as possible, we extended our latest focus to the family and genus ranks. We focused on Trichoderma for several reasons, mainly because the asexual and sexual synonyms were well documented, and a list of proposed names and type material were recently proposed and published. In this case study the recent taxonomic information was applied to do a complete taxonomic audit for the genus Trichoderma in the NCBI Taxonomy database. A name status report is available here: https://www.ncbi.nlm.nih.gov/Taxonomy/TaxIdentifier/tax_identifier.cgi. As a result, the ITS RefSeq Targeted Loci database at NCBI has been augmented with more sequences from type and verified material from Trichoderma species. Additionally, to aid in the cross referencing of data from single loci and genomes we have collected a list of quality records of the RPB2 gene obtained from type material in GenBank that could help validate future submissions. During the process of curation misidentified genomes were discovered, and sequence records from type material were found hidden under previous classifications. Source metadata curation, although more cumbersome, proved to be useful as confirmation of the type material designation. Database URL: http://www.ncbi.nlm.nih.gov/bioproject/PRJNA177353 PMID:29220466

Outcomes After Orbital Atherectomy of Severely Calcified Left Main Lesions: Analysis of the ORBIT II Study.

Science.gov (United States)

Lee, Michael S; Shlofmitz, Evan; Shlofmitz, Richard; Sahni, Sheila; Martinsen, Brad; Chambers, Jeffrey

2016-09-01

The ORBIT II trial reported excellent outcomes in patients with severely calcified coronary lesions treated with orbital atherectomy. Severe calcification of the left main (LM) artery represents a complex coronary lesion subset. This study evaluated the safety and efficacy of coronary orbital atherectomy to prepare severely calcified protected LM artery lesions for stent placement. The ORBIT II trial was a prospective, multicenter clinical trial that enrolled 443 patients with severely calcified coronary lesions in the United States. The major adverse cardiac event (MACE) rate through 2 years post procedure, defined by cardiac death, myocardial infarction (CK-MB >3x upper limit of normal with or without a new pathologic Q-wave) and target-vessel revascularization, was compared in the LM and non-left main (NLM) groups. Among the 443 patients, a total of 10 underwent orbital atherectomy of protected LM artery lesions. At 2 years, there was no significant difference in the 2-year MACE rate in the LM and NLM groups (30.0% vs 19.1%, respectively; P=.36). Cardiac death was low in both groups (0% vs 4.4%, respectively; P=.99). Myocardial infarction occurred within 30 days in both groups (10.0% vs 9.7%, respectively; P=.99). Severe dissection, perforation, persistent slow flow, and persistent no reflow did not occur in the LM group. Abrupt closure occurred in 1 patient in the LM group. Orbital atherectomy for patients with heavily calcified LM coronary artery lesions is safe and feasible. Further studies are needed to assess the safety and efficacy of orbital atherectomy in patients with severely calcified LM artery lesions.

Algorithms for contrast enhancement of electronic portal images

International Nuclear Information System (INIS)

Díez, S.; Sánchez, S.

2015-01-01

An implementation of two new automatized image processing algorithms for contrast enhancement of portal images is presented as suitable tools which facilitate the setup verification and visualization of patients during radiotherapy treatments. In the first algorithm, called Automatic Segmentation and Histogram Stretching (ASHS), the portal image is automatically segmented in two sub-images delimited by the conformed treatment beam: one image consisting of the imaged patient obtained directly from the radiation treatment field, and the second one is composed of the imaged patient outside it. By segmenting the original image, a histogram stretching can be independently performed and improved in both regions. The second algorithm involves a two-step process. In the first step, a Normalization to Local Mean (NLM), an inverse restoration filter is applied by dividing pixel by pixel a portal image by its blurred version. In the second step, named Lineally Combined Local Histogram Equalization (LCLHE), the contrast of the original image is strongly improved by a Local Contrast Enhancement (LCE) algorithm, revealing the anatomical structures of patients. The output image is lineally combined with a portal image of the patient. Finally the output images of the previous algorithms (NLM and LCLHE) are lineally combined, once again, in order to obtain a contrast enhanced image. These two algorithms have been tested on several portal images with great results. - Highlights: • Two Algorithms are implemented to improve the contrast of Electronic Portal Images. • The multi-leaf and conformed beam are automatically segmented into Portal Images. • Hidden anatomical and bony structures in portal images are revealed. • The task related to the patient setup verification is facilitated by the contrast enhancement then achieved.

Stemcell Information: SKIP000474 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

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Stemcell Information: SKIP000494 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available eyes Snake eyes ... Fetus Unknown ... -- No MRC-iPS-83|MRC5-derived iPS cells| MRC5由来iPS細胞| human ES-... SKIP000494 ... fetal lung fibroblast 胎児肺線維芽細胞 Unknown MRC-iPS-83 MRC-iPS-83 Snake ....2010.01459.x--10.1371/journal.pgen.1002085 Lectin microarray analysis of pluripotent and multipotent stem cell...s.--DNA methylation dynamics in human induced pluripotent stem cells over time. Toyoda M, Yamazaki-Inoue ....gov/pubmed/21155951--http://www.ncbi.nlm.nih.gov/pubmed/21637780 -- Some of clones of the same original cells have been used in the papers.

Stemcell Information: SKIP000498 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available y Diggity ... Fetus Unknown ... -- No MRC-iPS-86|MRC5-derived iPS cells| MRC5由来iPS細胞| human ES-like R... SKIP000498 ... fetal lung fibroblast 胎児肺線維芽細胞 Unknown MRC-iPS-86 MRC-iPS-86 Diggit...01459.x--10.1371/journal.pgen.1002085 Lectin microarray analysis of pluripotent and multipotent stem cells.-...-DNA methylation dynamics in human induced pluripotent stem cells over time. Toyoda M, Yamazaki-Inoue M, Ita...ubmed/21155951--http://www.ncbi.nlm.nih.gov/pubmed/21637780 -- Some of clones of the same original cells have been used in the papers.

Stemcell Information: SKIP000433 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available pper Gobstopper ... Fetus Unknown ... -- No MRC-iPS-21|MRC5-derived iPS cells| MRC5由来iPS細胞| human ES-... SKIP000433 ... fetal lung fibroblast 胎児肺線維芽細胞 Unknown MRC-iPS-21 MRC-iPS-21 Gobsto....2010.01459.x--10.1371/journal.pgen.1002085 Lectin microarray analysis of pluripotent and multipotent stem cell...s.--DNA methylation dynamics in human induced pluripotent stem cells over time. Toyoda M, Yamazaki-Inoue ....gov/pubmed/21155951--http://www.ncbi.nlm.nih.gov/pubmed/21637780 -- Some of clones of the same original cells have been used in the papers.

Stemcell Information: SKIP000478 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available g ... Fetus Unknown ... -- No MRC-iPS-66|MRC5-derived iPS cells| MRC5由来iPS細胞| human ES-like Research ... SKIP000478 ... fetal lung fibroblast 胎児肺線維芽細胞 Unknown MRC-iPS-66 MRC-iPS-66 Tug Tu...-10.1371/journal.pgen.1002085 Lectin microarray analysis of pluripotent and multipotent stem cells.--DNA met...hylation dynamics in human induced pluripotent stem cells over time. Toyoda M, Yamazaki-Inoue M, Itakura Y, ...155951--http://www.ncbi.nlm.nih.gov/pubmed/21637780 -- Some of clones of the same original cells have been used in the papers.

Stemcell Information: SKIP000457 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available s Jimmies ... Fetus Unknown ... -- No MRC-iPS-45|MRC5-derived iPS cells| MRC5由来iPS細胞| human ES-like R... SKIP000457 ... fetal lung fibroblast 胎児肺線維芽細胞 Unknown MRC-iPS-45 MRC-iPS-45 Jimmie...01459.x--10.1371/journal.pgen.1002085 Lectin microarray analysis of pluripotent and multipotent stem cells.-...-DNA methylation dynamics in human induced pluripotent stem cells over time. Toyoda M, Yamazaki-Inoue M, Ita...ubmed/21155951--http://www.ncbi.nlm.nih.gov/pubmed/21637780 -- Some of clones of the same original cells have been used in the papers.

Stemcell Information: SKIP000437 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available c ... Fetus Unknown ... -- No MRC-iPS-25|MRC5-derived iPS cells| MRC5由来iPS細胞| human ES-like Research ... SKIP000437 ... fetal lung fibroblast 胎児肺線維芽細胞 Unknown MRC-iPS-25 MRC-iPS-25 Tic Ti...-10.1371/journal.pgen.1002085 Lectin microarray analysis of pluripotent and multipotent stem cells.--DNA met...hylation dynamics in human induced pluripotent stem cells over time. Toyoda M, Yamazaki-Inoue M, Itakura Y, ...155951--http://www.ncbi.nlm.nih.gov/pubmed/21637780 -- Some of clones of the same original cells have been used in the papers.

Electron transfer in keV Li+-Na(3s, 3p) collisions: I. Atomic basis coupled-channel calculations

International Nuclear Information System (INIS)

Nielsen, S.E.; Dubois, A.

1995-01-01

Integral cross sections for electron capture from the ground state Na(3s) and excited states Na(3p) to Li(nlm), n = 2, 3, are calculated by the semiclassical impact-parameter method, using a two-centre atomic basis expansion. In the impact energy range 1-50 keV, results are analysed with particular emphasis on the alignment and orientation of initial and final p-states. At intermediate velocities opposite initial alignment effects are found for capture to n = 2 and n = 3 states, respectively. Orientation effects in state-to-state capture cross sections are predicted from oriented and tilted aligned initial states. (Author)

a Point-Like Picture of the Hydrogen Atom

Science.gov (United States)

Faghihi, F.; Jangjoo, A.; Khani, M.

A point-like picture of the Schrödinger solution for hydrogen atom is worked to emphasize that "point-like particles" may describe as "probability wave function". In each case, the three-dimensional shape of the |Ψnlm(rn, cosθ)|2 is plotted and the paths of the point-like electron (it is better to say reduced mass of the pair particles) are described in each closed shell. Finally, the orbital shape of the molecules are given according to the present simple model. In our opinion, "interpretations of the Correspondence Principle", which is a basic principle in all elementary quantum text, seems to be reviewed again!

Treatment of renal manifestations of ANCA-associated vasculitis.

Science.gov (United States)

Galesic, Kresimir; Ljubanovic, Danica; Horvatic, Ivica

2013-01-01

Vasculitis is a clinicopathological entity characterized by inflammation and necrosis of blood vessels. Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched. Two major autoantigens for ANCA are myeloperoxidase (MPO) and proteinase 3 (PR3), which are proteins in the primary granules of neutrophils and in the lysosomes of monocytes. They are expressed in mature neutrophils of patients with ANCA, while absent in healthy subjects. The kidney is the most commonly affected vital organ in ANCA-associated vasculitis, and patient outcomes are largely determined by the severity of renal disease at diagnosis and by its response to treatment.

What nephrolopathologists need to know about antiphospholipid syndrome-associated nephropathy: Is it time for formulating a classification for renal morphologic lesions?

Science.gov (United States)

Mubarak, Muhammed; Nasri, Hamid

2014-01-01

Antiphospholipid syndrome (APS) is a systemic autoimmune disorder which commonly affects kidneys. Directory of Open Access Journals (DOAJ), Google Scholar, PubMed (NLM), LISTA (EBSCO) and Web of Science have been searched. There is sufficient epidemiological, clinical and histopathological evidence to show that antiphospholipid syndrome is a distinctive lesion caused by antiphospholipid antibodies in patients with different forms of antiphospholipid syndrome. It is now time to devise a classification for an accurate diagnosis and prognostication of the disease. Now that the morphological lesions of APSN are sufficiently well characterized, it is prime time to devise a classification which is of diagnostic and prognostic utility in this disease.