General Vo Nguyen Giap: Operational Genius or Lucky Amateur

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1993-05-17

34蓞 fta "" Coat" Si0-650sa 0102-LF-014-66 02 ABSTRACT OF. GENERAL VO NGUYEN GIAP: OPERATIONAL GENIUS OR LUCKY AMATEUR? Over the course of 30 years, from...and the revolution in operation’al. (nkinZ he procipitated. 37 ENDNOTES 1. Stanley Karnow, Vietnam: A History (New York: Penguin Books, 1984), p. 58...isl. Now York: Penguin Books, 1984. O’Ncill, Robert J. GeAl i(p: Politicigan d Stratmdst. New York: Fredcrick A. Praeger, 1969. Pimlotk John. Vktnam

Mafutsuto-Ron: The First Anesthesia Textbook in the World. Bibliographic Review and English Translation.

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Dote, Kentaro; Ikemune, Keizo; Desaki, Yoko; Yorozuya, Tosihiro; Makino, Hiroshi

2015-10-01

On October 13, 1804, Seishu Hanaoka performed a mastectomy on Kan Aiya in Hirayama, Kii Province Japan, in what is considered to be the first operation under general anesthesia. She was anesthetized with a mixture of herbs known as Mafutsuto. Although Seishu did not record his anesthetic practices, his student, Gendai Kamada, documented the use of Mafutsuto in Mafutsuto-Ron. Written in 1839, Mafutsuto-Ron is 10 pages and covers six topics, including preoperative management, dosing and administering Mafutsuto, induction of general anesthesia, common errors, and postoperative precautions. Mafutsuto-Ron, therefore, meets the requirements to be considered the first extant anesthesia textbook. We present a complete English translation of Mafutsuto-Ron. Copyright © 2015 Elsevier B.V. All rights reserved.

Novel function of transcription factor Nrf2 as an inhibitor of RON tyrosine kinase receptor-mediated cancer cell invasion.

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Thangasamy, Amalraj; Rogge, Jessica; Krishnegowda, Naveen K; Freeman, James W; Ammanamanchi, Sudhakar

2011-09-16

Recepteur d' origine nantais (RON), a tyrosine kinase receptor, is aberrantly expressed in human tumors and promotes cancer cell invasion. RON receptor activation is also associated with resistance to tamoxifen treatment in breast cancer cells. Nrf2 is a positive regulator of cytoprotective genes. Using chromatin immunoprecipitation (ChIP) and site-directed mutagenesis studies of the RON promoter, we identified Nrf2 as a negative regulator of RON gene expression. High Nrf2 and low RON expression was observed in normal mammary tissue whereas high RON and low or undetectable expression of Nrf2 was observed in breast tumors. The Nrf2 inducer sulforaphane (SFN) as well as ectopic Nrf2 expression or knock-down of the Nrf2 negative regulator keap1, which stabilizes Nrf2, inhibited RON expression and invasion of carcinoma cells. Consequently, our studies identified a novel functional role for Nrf2 as a "repressor" and RON kinase as a molecular target of SFN, which mediates the anti-tumor effects of SFN. These results are not limited to breast cancer cells since the Nrf2 inducer SFN stabilized Nrf2 and inhibited RON expression in carcinoma cells from various tumor types.

Identification, characterization and antigenicity of the Plasmodium vivax rhoptry neck protein 1 (PvRON1

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Patarroyo Manuel E

2011-10-01

Full Text Available Abstract Background Plasmodium vivax malaria remains a major health problem in tropical and sub-tropical regions worldwide. Several rhoptry proteins which are important for interaction with and/or invasion of red blood cells, such as PfRONs, Pf92, Pf38, Pf12 and Pf34, have been described during the last few years and are being considered as potential anti-malarial vaccine candidates. This study describes the identification and characterization of the P. vivax rhoptry neck protein 1 (PvRON1 and examine its antigenicity in natural P. vivax infections. Methods The PvRON1 encoding gene, which is homologous to that encoding the P. falciparum apical sushi protein (ASP according to the plasmoDB database, was selected as our study target. The pvron1 gene transcription was evaluated by RT-PCR using RNA obtained from the P. vivax VCG-1 strain. Two peptides derived from the deduced P. vivax Sal-I PvRON1 sequence were synthesized and inoculated in rabbits for obtaining anti-PvRON1 antibodies which were used to confirm the protein expression in VCG-1 strain schizonts along with its association with detergent-resistant microdomains (DRMs by Western blot, and its localization by immunofluorescence assays. The antigenicity of the PvRON1 protein was assessed using human sera from individuals previously exposed to P. vivax malaria by ELISA. Results In the P. vivax VCG-1 strain, RON1 is a 764 amino acid-long protein. In silico analysis has revealed that PvRON1 shares essential characteristics with different antigens involved in invasion, such as the presence of a secretory signal, a GPI-anchor sequence and a putative sushi domain. The PvRON1 protein is expressed in parasite's schizont stage, localized in rhoptry necks and it is associated with DRMs. Recombinant protein recognition by human sera indicates that this antigen can trigger an immune response during a natural infection with P. vivax. Conclusions This study shows the identification and characterization of

How to assess the plasma delivery of RONS into tissue fluid and tissue

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Oh, Jun-Seok; Szili, Endre J.; Gaur, Nishtha; Hong, Sung-Ha; Furuta, Hiroshi; Kurita, Hirofumi; Mizuno, Akira; Hatta, Akimitsu; Short, Robert D.

2016-08-01

The efficacy of helium (He) and argon (Ar) plasma jets are being investigated for different healthcare applications including wound and cancer therapy, sterilisation and surface disinfections. Current research points to a potential link between the generation of reactive oxygen and nitrogen species (RONS) and outcomes in a range of biological and medical applications. As new data accrue, further strengthening this link, it becomes important to understand the controlled delivery of RONS into solutions, tissue fluids and tissues. This paper investigates the use of He and Ar plasma jets to deliver three RONS (hydrogen peroxide—H2O2, nitrite—\\text{NO}2- and nitrate—\\text{NO}3- ) and molecular oxygen (O2) directly into deionised (DI) water, or indirectly into DI water through an agarose target. The DI water is used in place of tissue fluid and the agarose target serves as a surrogate of tissue. Direct plasma jet treatments deliver more RONS and O2 than the through-agarose treatments for equivalent treatments times. The former only deliver RONS whilst the plasma jets are ignited; the latter continues to deliver RONS into the DI water long after the plasmas are extinguished. The He plasma jet is more effective at delivering H2O2 and \\text{NO}2- directly into DI water, but the Ar plasma jet is more effective at nitrating the DI water in both direct and through-agarose treatments. DI water directly treated with the plasma jets is deoxygenated, with the He plasma jet purging more O2 than the Ar plasma jet. This effect is known as ‘sparging’. In contrast, for through-agarose treatments both jets oxygenated the DI water. These results indicate that in the context of direct and indirect plasma jet treatments of real tissue fluids and tissue, the choice of process gas (He or Ar) could have a profound effect on the concentrations of RONS and O2. Irrespective of operating gas, sparging of tissue fluid (in an open wound) for long prolonged periods during direct plasma

DMPD: Macrophage-stimulating protein and RON receptor tyrosine kinase: potentialregulators of macrophage inflammatory activities. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 12472665 Macrophage-stimulating protein and RON receptor tyrosine kinase: potential...:545-53. (.png) (.svg) (.html) (.csml) Show Macrophage-stimulating protein and RON receptor tyrosine kinase:...le Macrophage-stimulating protein and RON receptor tyrosine kinase: potentialregulators of macrophage inflam

Characterizing the Hot Spots Involved in RON-MSPβ Complex Formation Using In Silico Alanine Scanning Mutagenesis and Molecular Dynamics Simulation

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Omid Zarei

2017-04-01

Full Text Available Purpose: Implication of protein-protein interactions (PPIs in development of many diseases such as cancer makes them attractive for therapeutic intervention and rational drug design. RON (Recepteur d’Origine Nantais tyrosine kinase receptor has gained considerable attention as promising target in cancer therapy. The activation of RON via its ligand, macrophage stimulation protein (MSP is the most common mechanism of activation for this receptor. The aim of the current study was to perform in silico alanine scanning mutagenesis and to calculate binding energy for prediction of hot spots in protein-protein interface between RON and MSPβ chain (MSPβ. Methods: In this work the residues at the interface of RON-MSPβ complex were mutated to alanine and then molecular dynamics simulation was used to calculate binding free energy. Results: The results revealed that Gln193, Arg220, Glu287, Pro288, Glu289, and His424 residues from RON and Arg521, His528, Ser565, Glu658, and Arg683 from MSPβ may play important roles in protein-protein interaction between RON and MSP. Conclusion: Identification of these RON hot spots is important in designing anti-RON drugs when the aim is to disrupt RON-MSP interaction. In the same way, the acquired information regarding the critical amino acids of MSPβ can be used in the process of rational drug design for developing MSP antagonizing agents, the development of novel MSP mimicking peptides where inhibition of RON activation is required, and the design of experimental site directed mutagenesis studies.

Isolation of Fully Human Antagonistic RON Antibodies Showing Efficient Block of Downstream Signaling and Cell Migration1

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Gunes, Zeynep; Zucconi, Adriana; Cioce, Mario; Meola, Annalisa; Pezzanera, Monica; Acali, Stefano; Zampaglione, Immacolata; De Pratti, Valeria; Bova, Luca; Talamo, Fabio; Demartis, Anna; Monaci, Paolo; La Monica, Nicola; Ciliberto, Gennaro; Vitelli, Alessandra

2011-01-01

RON belongs to the c-MET family of receptor tyrosine kinases. As its well-known family member MET, RON and its ligand macrophage-stimulating protein have been implicated in the progression and metastasis of tumors and have been shown to be overexpressed in cancer. We generated and tested a large number of human monoclonal antibodies (mAbs) against human RON. Our screening yielded three high-affinity antibodies that efficiently block ligand-dependent intracellular AKT and MAPK signaling. This effect correlates with the strong reduction of ligand-activated migration of T47D breast cancer cell line. By cross-competition experiments, we showed that the antagonistic antibodies fall into three distinct epitope regions of the RON extracellular Sema domain. Notably, no inhibition of tumor growth was observed in different epithelial tumor xenografts in nude mice with any of the antibodies. These results suggest that distinct properties beside ligand antagonism are required for anti-RON mAbs to exert antitumor effects in vivo. PMID:21286376

Mapping surrogate gasoline compositions into RON/MON space

NARCIS (Netherlands)

Morgan, N.; Smallbone, A.; Bhave, A.; Kraft, M.; Cracknell, R.; Kalghatgi, G.T.

2010-01-01

In this paper, new experimentally determined octane numbers (RON and MON) of blends of a tri-component surrogate consisting of toluene, n-heptane, i-octane (called toluene reference fuel TRF) arranged in an augmented simplex design are used to derive a simple response surface model for the octane

Ron Scott d/b/a White Dog Painting Information Sheet

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Ron Scott d/b/a White Dog Painting (the Company) is located in Kansas City, Missouri. The settlement involves renovation activities conducted at property constructed prior to 1978, located in Kansas City, Missouri.

The RON receptor tyrosine kinase in pancreatic cancer pathogenesis and its potential implications for future targeted therapies.

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Kang, Chang Moo; Babicky, Michele L; Lowy, Andrew M

2014-03-01

Pancreatic cancer remains a devastating disease with a mortality rate that has not changed substantially in decades. Novel therapies are therefore desperately needed. The RON receptor tyrosine kinase has been identified as an important mediator of KRAS oncogene addiction and is overexpressed in the majority of pancreatic cancers. Preclinical studies show that inhibition of RON function decreases pancreatic cancer cell migration, invasion, and survival and can sensitize pancreatic cancer cells to chemotherapy. This article reviews the current state of knowledge regarding RON biology and pancreatic cancer and discusses its potential as a therapeutic target.

Ron Logan: An Insider's View of the Music Industry.

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Van Zandt, Kathryn

2002-01-01

Presents an interview with Ron Logan who has served as an executive vice president for Walt Disney Entertainment. Focuses on topics, such as: influential teachers in his life, his career, how he selects scripts for musical productions, and advice for students who want to work in the music industry. (CMK)

Targeting the Ron-Dek Signaling Axis in Breast Cancer

Science.gov (United States)

2015-09-01

Words 5 Accomplishments 5 Impact & Conclusion 8 Changes/Problems 9 Products 9 Participants and Other Collaborating Organizations 11 Special...may represent an important new therapeutic option for the treatment of breast cancer. 2. KEY WORDS Ron receptor, Dek, beta-catenin, breast cancer 3...Finally, our data showed that Dek overexpression promoted tumorigenic properties in immortalized human mammary epithelial MCF10A cells and in the context

Glycomic analysis of gastric carcinoma cells discloses glycans as modulators of RON receptor tyrosine kinase activation in cancer

DEFF Research Database (Denmark)

Mereiter, Stefan; Magalhães, Ana; Adamczyk, Barbara

2016-01-01

gastric carcinoma cells transfected with the sialyltransferase ST3GAL4 were established as a model overexpressing sialylated terminal glycans. We have evaluated at the structural level the glycome and the sialoproteome of this gastric cancer cell line applying liquid chromatography and mass spectrometry...... known to be key players in malignancy. Further analysis of RON confirmed its modification with SLe(X) and the concomitant activation. SLe(X) and RON co-expression was validated in gastric tumors. CONCLUSION: The overexpression of ST3GAL4 interferes with the overall glycophenotype of cancer cells...... affecting a multitude of key proteins involved in malignancy. Aberrant glycosylation of the RON receptor was shown as an alternative mechanism of oncogenic activation. GENERAL SIGNIFICANCE: This study provides novel targets and points to an integrative tumor glycomic/proteomic-profiling for gastric cancer...

Laminar burning velocities at elevated pressures for gasoline and gasoline surrogates associated with RON

KAUST Repository

Mannaa, Ossama

2015-06-01

The development and validation of a new gasoline surrogate using laminar flame speed as a target parameter is presented. Laminar burning velocities were measured using a constant-volume spherical vessel with ignition at the center of the vessel. Tested fuels included iso-octane, n-heptane, toluene, various mixtures of primary reference fuels (PRFs) and toluene reference fuels (TRFs) and three gasoline fuels of 70, 85 and 95 RON (FACE J, C and F) at the initial temperature of 358K and pressures up to 0.6MPa in the equivalence ratio ranging from 0.8 to 1.6. Normalized laminar burning velocity data were mapped into a tri-component mixture space at different experimental conditions to allocate different gasoline surrogates for different gasoline fuels, having RON of 70, 85 and 95. The surrogates of TRF-70-4 (17.94% iso-C8H18 +42.06% n-C7H16 +40% C7H8), TRF-85-1 (77.4% iso-C8H18 +17.6% n-C7H16 +5% C7H8), and TRF-95-1 (88.47% iso-C8H18 +6.53% n-C7H16 +5% C7H8) of RON 70, 85 and 95, respectively, are shown to successfully emulate the burning rate characteristics of the gasoline fuels associated with these RONs under the various experimental conditions investigated. An empirical correlation was derived to obtain laminar burning velocities at pressures that are experimentally unattainable as high as 3.0MPa. Laminar burning velocities were comparable to the simulated values for lean and stoichiometric flames but they were relatively higher than the simulated values for rich flames. A flame instability assessment was conducted by determining Markstein length, critical Pecklet number, and critical Karlovitz number at the onset of flame instability.

Transformation and scattering activities of the receptor tyrosine kinase RON/Stk in rodent fibroblasts and lack of regulation by the jaagsiekte sheep retrovirus receptor, Hyal2

International Nuclear Information System (INIS)

Miller, A Dusty; Van Hoeven, Neal S; Liu, Shan-Lu

2004-01-01

The envelope (Env) protein of jaagsiekte sheep retrovirus (JSRV) can transform cells in culture and is likely to be the main factor responsible for lung cancer induction by JSRV in animals. A recent report indicates that the epithelial-cell transforming activity of JSRV Env depends on activation of the cell-surface receptor tyrosine kinase Mst1r (called RON for the human and Stk for the rodent orthologs). In the immortalized line of human epithelial cells used (BEAS-2B cells), the virus receptor Hyal2 was found to bind to and suppress the activity of RON. When Env was expressed it bound to Hyal2 causing its degradation, release of RON activity from Hyal2 suppression, and activation of pathways resulting in cell transformation. Due to difficulty with reproducibility of the transformation assay in BEAS-2B cells, we have used more tractable rodent fibroblast models to further study Hyal2 modulation of RON/Stk transforming activity and potential effects of Hyal2 on RON/Stk activation by its natural ligand, macrophage stimulating protein (MSP). We did not detect transformation of NIH 3T3 cells by plasmids expressing RON or Stk, but did detect transformation of 208F rat fibroblasts by these plasmids at a very low rate. We were able to isolate 208F cell clones that expressed RON or Stk and that showed changes in morphology indicative of transformation. The parental 208F cells did not respond to MSP but 208F cells expressing RON or Stk showed obvious increases in scattering/transformation in response to MSP. Human Hyal2 had no effect on the basal or MSP-induced phenotypes of RON-expressing 208F cells, and human, mouse or rat Hyal2 had no effect on the basal or MSP-induced phenotypes of Stk-expressing 208F cells. We have shown that RON or Stk expression in 208F rat fibroblasts results in a transformed phenotype that is enhanced by addition of the natural ligand for these proteins, MSP. Hyal2 does not directly modulate the basal or MSP-induced RON/Stk activity, although it

The association and a potential pathway between gender-based violence and induced abortion in Thai Nguyen province, Vietnam

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Phuong Hong Nguyen

2012-11-01

Full Text Available Background: Gender-based violence (GBV has profound adverse consequences on women's physical, mental, and reproductive health. Although Vietnam has high rates of induced abortion and GBV, literature examining this relationship is lacking. Objective: This study examines the association of GBV with induced abortion among married or partnered women of reproductive age in Thai Nguyen province, Vietnam. In addition, we explore contraceptive use and unintended pregnancy as mediators in the pathway between GBV and induced abortion. Design and methods: Data were drawn from a cross-sectional survey of 1,281 women aged 18–49 years in four districts of Thai Nguyen province. Bivariate and multivariate logistic regression analyses were applied to examine the associations between lifetime history of GBV, contraceptive use, unintended pregnancy, induced abortion, and repeat abortion, controlling for other covariates. Results: One-third of respondents had undergone induced abortion in their lifetime (33.4%, and 11.5% reported having repeat abortions. The prevalence of any type of GBV was 29.1% (17.0% physical violence, 10.4% sexual violence, and 20.1% emotional violence. History of GBV was associated with induced abortion (OR=1.61, 95% CI: 1.20–2.16 and repeat abortion (OR=2.22, 95% CI: 1.48–3.32. Physical violence was significantly associated with induced abortion, and all three types of violence were associated with repeat abortion. Abused women were more likely than non-abused women to report using contraceptives and having an unintended pregnancy, and these factors were in turn associated with increased risk of induced abortion. Conclusions: GBV is pervasive in Thai Nguyen province and is linked to increased risks of induced abortion and repeat abortion. The findings suggest that a pathway underlying this relationship is increased risk of unintended pregnancy due in part to ineffective use of contraceptives. These findings emphasize the importance of

The association and a potential pathway between gender-based violence and induced abortion in Thai Nguyen province, Vietnam.

Science.gov (United States)

Nguyen, Phuong Hong; Nguyen, Son Van; Nguyen, Manh Quang; Nguyen, Nam Truong; Keithly, Sarah Colleen; Mai, Lan Tran; Luong, Loan Thi Thu; Pham, Hoa Quynh

2012-11-29

Gender-based violence (GBV) has profound adverse consequences on women's physical, mental, and reproductive health. Although Vietnam has high rates of induced abortion and GBV, literature examining this relationship is lacking. This study examines the association of GBV with induced abortion among married or partnered women of reproductive age in Thai Nguyen province, Vietnam. In addition, we explore contraceptive use and unintended pregnancy as mediators in the pathway between GBV and induced abortion. Data were drawn from a cross-sectional survey of 1,281 women aged 18-49 years in four districts of Thai Nguyen province. Bivariate and multivariate logistic regression analyses were applied to examine the associations between lifetime history of GBV, contraceptive use, unintended pregnancy, induced abortion, and repeat abortion, controlling for other covariates. One-third of respondents had undergone induced abortion in their lifetime (33.4%), and 11.5% reported having repeat abortions. The prevalence of any type of GBV was 29.1% (17.0% physical violence, 10.4% sexual violence, and 20.1% emotional violence). History of GBV was associated with induced abortion (OR=1.61, 95% CI: 1.20-2.16) and repeat abortion (OR=2.22, 95% CI: 1.48-3.32). Physical violence was significantly associated with induced abortion, and all three types of violence were associated with repeat abortion. Abused women were more likely than non-abused women to report using contraceptives and having an unintended pregnancy, and these factors were in turn associated with increased risk of induced abortion. GBV is pervasive in Thai Nguyen province and is linked to increased risks of induced abortion and repeat abortion. The findings suggest that a pathway underlying this relationship is increased risk of unintended pregnancy due in part to ineffective use of contraceptives. These findings emphasize the importance of screening and identification of GBV and incorporating women's empowerment in

Empirical Results of Modeling EUR/RON Exchange Rate using ARCH, GARCH, EGARCH, TARCH and PARCH models

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Andreea – Cristina PETRICĂ

2017-03-01

Full Text Available The aim of this study consists in examining the changes in the volatility of daily returns of EUR/RON exchange rate using on the one hand symmetric GARCH models (ARCH and GARCH and on the other hand the asymmetric GARCH models (EGARCH, TARCH and PARCH, since the conditional variance is time-varying. The analysis takes into account daily quotations of EUR/RON exchange rate over the period of 04th January 1999 to 13th June 2016. Thus, we are modeling heteroscedasticity by applying different specifications of GARCH models followed by looking for significant parameters and low information criteria (minimum Akaike Information Criterion. All models are estimated using the maximum likelihood method under the assumption of several distributions of the innovation terms such as: Normal (Gaussian distribution, Student’s t distribution, Generalized Error distribution (GED, Student’s with fixed df. Distribution, and GED with fixed parameter distribution. The predominant models turned out to be EGARCH and PARCH models, and the empirical results point out that the best model for estimating daily returns of EUR/RON exchange rate is EGARCH(2,1 with Asymmetric order 2 under the assumption of Student’s t distributed innovation terms. This can be explained by the fact that in case of EGARCH model, the restriction regarding the positivity of the conditional variance is automatically satisfied.

Phytoremediation potential of indigenous plants from Thai Nguyen province, Vietnam.

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Anh, Bui Thi Kim; Kim, Dang Dinh; Tua, Tran Van; Kien, Nguyen Trung; Anh, Do Tuan

2011-03-01

This study was focused on determining Arsenic (As), Lead (Pb), Cadmium (Cd) and Zinc (Zn) in 33 indigenous plants and 12 soil in-situ plant samples in Thai Nguyen Province, Vietnam. The results showed that the soils of surveyed mining areas contained 181.2- 6754.3 mg kg(-1) As, 235.5-4337.2 mg kg(-1) Pb, 0.8- 419 mg kg(-1) Cd and 361.8-17565.1 mg kg(-1) Zn depending on the characteristics of each mining site. These values are much higher than those typical for normal soil. The heavy metal uptake into shoots and roots of 33 indigenous plant species was also determined. Two species of the plants investigated, Pteris vittata L. and Pityrogramma calomelanos L. were As hyperaccumulators, containing more than 0.1% heavy metals in their shoots. Eleusine indica L., Cynodon dactylon L., Cyperus rotundus L. and Equisetum ramosissimum (Vauch) accumulate very high Pb (0.15-0.65%) and Zn (0.22-1.56%) concentration in their roots. Additional experiments to clarify the potential of six these plants as good candidates for phytoremediation of heavy metal pollution soil are being carried out in our laboratory.

Monoclonal antibody Zt/g4 targeting RON receptor tyrosine kinase enhances chemosensitivity of bladder cancer cells to Epirubicin by promoting G1/S arrest and apoptosis.

Science.gov (United States)

Chen, Jun-Feng; Yu, Bi-Xia; Yu, Rui; Ma, Liang; Lv, Xiu-Yi; Cheng, Yue; Ma, Qi

2017-02-01

Epirubicin (EPI) is one of the most used intravesical chemotherapy agents after transurethral resection to non-muscle invasive bladder tumors (NMIBC) to prevent cancer recurrence and progression. However, even after resection of bladder tumors and intravesical chemotherapy, half of them will recur and progress. RON is a membrane tyrosine kinase receptor usually overexpressed in bladder cancer cells and associated with poor pathological features. This study aims to investigate the effects of anti-RON monoclonal antibody Zt/g4 on the chemosensitivity of bladder cells to EPI. After Zt/g4 treatment, cell cytotoxicity was significantly increased and cell invasion was markedly suppressed in EPI-treated bladder cancer cells. Further investigation indicated that combing Zt/g4 with EPI promoted cell G1/S-phase arrest and apoptosis, which are the potential mechanisms that RON signaling inhibition enhances chemosensitivity of EPI. Thus, combing antibody-based RON targeted therapy enhances the therapeutic effects of intravesical chemotherapy, which provides new strategy for further improvement of NMIBC patient outcomes.

Prevalence, Awareness, Treatment, and Control of High Blood Pressure: A Population-Based Survey in Thai Nguyen, Vietnam.

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Duc Anh Ha

Full Text Available Cardiovascular disease (CVD is one of the leading causes of morbidity and mortality in Vietnam and hypertension (HTN is an important and prevalent risk factor for CVD in the adult Vietnamese population. Despite an increasing prevalence of HTN in this country, information about the awareness, treatment, and control of HTN is limited. The objectives of this study were to describe the prevalence, awareness, treatment, and control of HTN, and factors associated with these endpoints, in residents of a mountainous province in Vietnam.Data from 2,368 adults (age≥25 years participating in a population-based survey conducted in 2011 in Thai Nguyen province were analyzed. All eligible participants completed a structured questionnaire and were examined by community health workers using a standardized protocol.The overall prevalence of HTN in this population was 23%. Older age, male sex, and being overweight were associated with a higher odds of having HTN, while higher educational level was associated with a lower odds of having HTN. Among those with HTN, only 34% were aware of their condition, 43% of those who were aware they had HTN received treatment and, of these, 39% had their HTN controlled.Nearly one in four adults in Thai Nguyen is hypertensive, but far fewer are aware of this condition and even fewer have their blood pressure adequately controlled. Public health strategies increasing awareness of HTN in the community, as well as improvements in the treatment and control of HTN, remain needed to reduce the prevalence of HTN and related morbidity and mortality.

Comparison of catalytic converter performance in internal combustion engine fueled with Ron 95 and Ron 97 gasoline

Science.gov (United States)

Leman, A. M.; Rahman, Fakhrurrazi; Jajuli, Afiqah; Feriyanto, Dafit; Zakaria, Supaat

2017-09-01

Generating ideal stability between engine performance, fuel consumption and emission is one of the main challenges in the automotive industry. The characteristics of engine combustion and creation of emission might simply change with different types of operating parameters. This study aims in investigating the relationship between two types of fuels on the performance and exhaust emission of internal combustion engine using ceramic and metallic catalytic converters. Experimental tests were performed on Mitsubishi 4G93 engine by applying several ranges of engine speeds to determine the conversion of pollutant gases released by the engine. The obtained results specify that the usage of RON 97 equipped with metallic converters might increase the conversion percentage of 1.31% for CO and 126 ppm of HC gases. The metallic converters can perform higher conversion compared to ceramic because in the high space velocities, metallic has higher surface geometry area and higher amount of transverse Peclet number (Pi). Ceramic converters achieved conversion at 2496 ppm of NOx gas, which is higher than the metallic converter.

Ribosomal Protein S6 Kinase (RSK-2 as a central effector molecule in RON receptor tyrosine kinase mediated epithelial to mesenchymal transition induced by macrophage-stimulating protein

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Zhang Rui-Wen

2011-05-01

Full Text Available Abstract Background Epithelial to mesenchymal transition (EMT occurs during cancer cell invasion and malignant metastasis. Features of EMT include spindle-like cell morphology, loss of epithelial cellular markers and gain of mesenchymal phenotype. Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein (MSP has been implicated in cellular EMT program; however, the major signaling determinant(s responsible for MSP-induced EMT is unknown. Results The study presented here demonstrates that RSK2, a downstream signaling protein of the Ras-Erk1/2 pathway, is the principal molecule that links MSP-activated RON signaling to complete EMT. Using MDCK cells expressing RON as a model, a spindle-shape based screen was conducted, which identifies RSK2 among various intracellular proteins as a potential signaling molecule responsible for MSP-induced EMT. MSP stimulation dissociated RSK2 with Erk1/2 and promoted RSK2 nuclear translocation. MSP strongly induced RSK2 phosphorylation in a dose-dependent manner. These effects relied on RON and Erk1/2 phosphorylation, which is significantly potentiated by transforming growth factor (TGF-β1, an EMT-inducing cytokine. Specific RSK inhibitor SL0101 completely prevented MSP-induced RSK phosphorylation, which results in inhibition of MSP-induced spindle-like morphology and suppression of cell migration associated with EMT. In HT-29 cancer cells that barely express RSK2, forced RSK2 expression results in EMT-like phenotype upon MSP stimulation. Moreover, specific siRNA-mediated silencing of RSK2 but not RSK1 in L3.6pl pancreatic cancer cells significantly inhibited MSP-induced EMT-like phenotype and cell migration. Conclusions MSP-induced RSK2 activation is a critical determinant linking RON signaling to cellular EMT program. Inhibition of RSK2 activity may provide a therapeutic opportunity for blocking RON-mediated cancer cell migration and subsequent invasion.

Role of PAX8 in the regulation of MET and RON receptor tyrosine kinases in non-small cell lung cancer

International Nuclear Information System (INIS)

Kanteti, Rajani; El-Hashani, Essam; Dhanasingh, Immanuel; Tretiakova, Maria; Husain, Aliya N; Sharma, Sherven; Sharma, Jay; Vokes, Everett E; Salgia, Ravi

2014-01-01

Non-small cell lung cancers (NSCLC) are highly heterogeneous at the molecular level and comprise 75% of all lung tumors. We have previously shown that the receptor tyrosine kinase (RTK) MET frequently suffers gain-of-function mutations that significantly promote lung tumorigenesis. Subsequent studies from our lab also revealed that PAX5 transcription factor is preferentially expressed in small cell lung cancer (SCLC) and promotes MET transcription. PAX8, however, is also expressed in NSCLC cell lines. We therefore investigated the role of PAX8 in NSCLC. Using IHC analysis, PAX8 protein expression was determined in archival NSCLC tumor tissues (n = 254). In order to study the effects of PAX8 knockdown on NSCLC cellular functions such as apoptosis and motility, siRNA against PAX8 was used. Confocal fluorescence microscopy was used to monitor the localization of MET, RON and PAX8. The combinatorial effect of PAX8 knockdown and MET inhibition using SU11274 was investigated in NSCLC cell viability assay. Relative levels of PAX8 protein were elevated (≥ + 2 on a scale of 0–3) in adenocarcinoma (58/94), large cell carcinoma (50/85), squamous cell carcinoma (28/47), and metastatic NSCLC (17/28; lymph node). Utilizing early progenitors isolated from NSCLC cell lines and fresh tumor tissues, we observed robust overexpression of PAX8, MET, and RON. PAX8 knockdown A549 cells revealed abrogated PAX8 expression with a concomitant loss in MET and the related RON kinase expression. A dramatic colocalization between the active form of MET (also RON) and PAX8 upon challenging A549 cells with HGF was visualized. A similar colocalization of MET and EGL5 (PAX8 ortholog) proteins was found in embryos of C. elegans. Most importantly, knockdown of PAX8 in A549 cells resulted in enhanced apoptosis (~6 fold) and decreased cell motility (~45%), thereby making PAX8 a potential therapeutic target. However, the combinatorial approach of PAX8 knockdown and treatment with MET inhibitor, SU

The effect of temperature on cardiovascular disease hospital admissions among elderly people in Thai Nguyen Province, Vietnam

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Pham Ngan Giang

2014-12-01

Full Text Available Background: Projected increases in weather variability due to climate change will have severe consequences on human health, increasing mortality, and disease rates. Among these, cardiovascular diseases (CVD, highly prevalent among the elderly, have been shown to be sensitive to extreme temperatures and heat waves. Objectives: This study aimed to find out the relationship between daily temperature (and other weather parameters and daily CVD hospital admissions among the elderly population in Thai Nguyen province, a northern province of Vietnam. Methods: Retrospective data of CVD cases were obtained from a data base of four hospitals in Thai Nguyen province for a period of 5 years from 2008 to 2012. CVD hospital admissions were aggregated by day and merged with daily weather data from this period. Distributed lag non-linear model (DLNM was used to derive specific estimates of the effect of weather parameters on CVD hospital admissions of up to 30 days, adjusted for time trends using b-splines, day of the week, and public holidays. Results: This study shows that the average point of minimum CVD admissions was at 26°C. Above and below this threshold, the cumulative CVD admission risk over 30 lag days tended to increase with both lower and higher temperatures. The cold effect was found to occur 4–15 days following exposure, peaking at a week's delay. The cumulative effect of cold exposure on CVD admissions was statistically significant with a relative risk of 1.12 (95% confidence interval: 1.01–1.25 for 1°C decrease below the threshold. The cumulative effect of hot temperature on CVD admissions was found to be non-significant and was estimated to be at a relative risk of 1.17 (95% confidence interval: 0.90–1.52 for 1°C increase in the temperature. No significant association was found between CVD admissions and the other weather variables. Conclusion: Exposure to cold temperature is associated with increasing CVD admission risk among the

Robillard, Amy E. and Ron Fortune (eds. Authorship Contested. Cultural Challenges to the Authentic Autonomous Author (New York, and London: Routledge, 2015

Directory of Open Access Journals (Sweden)

Alex Ciorogar

2016-12-01

Full Text Available A review of Amy E. Robillard and Ron Fortune's (eds Authorship Contested: Cultural Challenges to the Authentic Autonomous Author. New York, and London: Routledge, 2015. 214 pp. £100.

Analisa Pengaruh Promosi Dan Hedonic Motivation Terhadap Impulse Buying Di Ron's Laboratory Galaxy Mall Surabaya

OpenAIRE

TJANTOKO, LAURA ELISABETH

2015-01-01

Food is a basic human needs are primary because every human need food to provide nutrients and energy to the body. This is an opportunity for business people to open the food business. It can be seen that the market of food business is getting more and more and has developed every year. One of the food business that are popular today is Ron's Laboratory. Business that specializes in desserts kind of ice cream / gelato is favored by the public. Although it has been known by the people does not...

THE IMPACT OF POLITICAL AND ECONOMIC NEWS ON THE EURO/RON EXCHANGE RATE: A GARCH APPROACH

OpenAIRE

Cristi Spulbar; Mihai Nitoi

2012-01-01

Within this study we try to capture the impact of political news and economic news from euro area on the exchange rate between Romanian currency and euro. In order to do this we used a GARCH model. As we observed, both variables influence the exchange rate, this fact implying national currency depreciation and a volatility growth. The political news and the economic news positively affect the euro/ron exchange rate volatility. The two factors conjugation, as it has happened in the recent peri...

The determinants of exchange rates and the movements of EUR/RON exchange rate via non-linear stochastic processes

Directory of Open Access Journals (Sweden)

Petrică Andreea-Cristina

2017-07-01

Full Text Available Modeling exchange rate volatility became an important topic for research debate starting with 1973, when many countries switched to floating exchange rate system. In this paper, we focus on the EUR/RON exchange rate both as an economic measure and present the implied economic links, and also as a financial investment and analyze its movements and fluctuations through two volatility stochastic processes: the Standard Generalized Autoregressive Conditionally Heteroscedastic Model (GARCH and the Exponential Generalized Autoregressive Conditionally Heteroscedastic Model (EGARCH. The objective of the conditional variance processes is to capture dependency in the return series of the EUR/RON exchange rate. On this account, analyzing exchange rates could be seen as the input for economic decisions regarding Romanian macroeconomics - the exchange rates being influenced by many factors such as: interest rates, inflation, trading relationships with other countries (imports and exports, or investments - portfolio optimization, risk management, asset pricing. Therefore, we talk about political stability and economic performance of a country that represents a link between the two types of inputs mentioned above and influences both the macroeconomics and the investments. Based on time-varying volatility, we examine implied volatility of daily returns of EUR/RON exchange rate using the standard GARCH model and the asymmetric EGARCH model, whose parameters are estimated through the maximum likelihood method and the error terms follow two distributions (Normal and Student’s t. The empirical results show EGARCH(2,1 with Asymmetric order 2 and Student’s t error terms distribution performs better than all the estimated standard GARCH models (GARCH(1,1, GARCH(1,2, GARCH(2,1 and GARCH(2,2. This conclusion is supported by the major advantage of the EGARCH model compared to the GARCH model which consists in allowing good and bad news having different impact on the

THE IMPACT OF POLITICAL AND ECONOMIC NEWS ON THE EURO/RON EXCHANGE RATE: A GARCH APPROACH

Directory of Open Access Journals (Sweden)

Mihai Niţoi

2012-12-01

Full Text Available Within this study we try to capture the impact of political news and economic news from euro area on the exchange rate between Romanian currency and euro. In order to do this we used a GARCH model. As we observed, both variables influence the exchange rate, this fact implying national currency depreciation and a volatility growth. The political news and the economic news positively affect the euro/ron exchange rate volatility. The two factors conjugation, as it has happened in the recent period is to be avoided because it can have financial and economic consequences with a very high cost for Romania.

Autoignition of isooctane beyond RON and MON conditions

KAUST Repository

Masurier, Jean-Baptiste; Waqas, Muhammad; Sarathy, Mani; Johansson, Bengt

2018-01-01

The present study experimentally examines the low temperature autoignition area of isooctane within the in-cylinder pressure - in-cylinder temperature map. Experiments were run with the help of a CFR engine. The boundaries of this engine were extended so that experiments could be performed outside the domain delimited by RON and MON traces. Since HCCI combustion is governed by kinetics, the rotation speed for all the experiments was set at 600 rpm to allow time for low temperature heat release (LTHR). All the other parameters (intake pressure, intake temperature, compression ratio and equivalence ratio), were scanned, such as the occurrence of isooctane combustion. The principal results showed that LTHR for isooctane occurs effortlessly under high intake pressure (1.3 bar) and low intake temperature (25 °C). Increasing the intake temperature leads to the loss of the LTHR, and therefore to a smaller domain on the pressure-temperature trace. In such a case, the LTHR domain is restricted from 20 to 50 bar in pressure and from 600 to 850 K in temperature. By slightly decreasing the intake pressure, the LTHR domain remains unchanged, but the LTHR tends to disappear, and finally, at 1.0 bar, the LTHR domain ceases to exist. When the equivalence ratio is moved from 0.3 to 0.4, the LTHR domain is delimited in the same range of pressure and temperature, but the start of combustion occurs slightly earlier for the same pressure-temperature trace. Similar conclusions were drawn regarding the variation of both intake pressure and temperature, except that few LTHR points were observed under 1.0 bar intake.

Autoignition of isooctane beyond RON and MON conditions

KAUST Repository

Masurier, Jean-Baptiste

2018-04-03

The present study experimentally examines the low temperature autoignition area of isooctane within the in-cylinder pressure - in-cylinder temperature map. Experiments were run with the help of a CFR engine. The boundaries of this engine were extended so that experiments could be performed outside the domain delimited by RON and MON traces. Since HCCI combustion is governed by kinetics, the rotation speed for all the experiments was set at 600 rpm to allow time for low temperature heat release (LTHR). All the other parameters (intake pressure, intake temperature, compression ratio and equivalence ratio), were scanned, such as the occurrence of isooctane combustion. The principal results showed that LTHR for isooctane occurs effortlessly under high intake pressure (1.3 bar) and low intake temperature (25 °C). Increasing the intake temperature leads to the loss of the LTHR, and therefore to a smaller domain on the pressure-temperature trace. In such a case, the LTHR domain is restricted from 20 to 50 bar in pressure and from 600 to 850 K in temperature. By slightly decreasing the intake pressure, the LTHR domain remains unchanged, but the LTHR tends to disappear, and finally, at 1.0 bar, the LTHR domain ceases to exist. When the equivalence ratio is moved from 0.3 to 0.4, the LTHR domain is delimited in the same range of pressure and temperature, but the start of combustion occurs slightly earlier for the same pressure-temperature trace. Similar conclusions were drawn regarding the variation of both intake pressure and temperature, except that few LTHR points were observed under 1.0 bar intake.

Contamination of supplements: an interview with professor Ron Maughan by Louise M. Burke.

Science.gov (United States)

Maughan, Ron

2004-08-01

This issue of IJSNEM features two articles related to supplement use by athletes. In one (Morrison et al. 2004), people who undertake regular exercise in a gym were found to report the use of a wide variety of supplements. The other paper (Goel et al. 2004) dealt with one of the issues that a sub-group of athletes need to consider before deciding to take supplements - the risk of a positive drug test if the product contains substances banned by the anti-doping codes under which their sport is conducted. This issue received much publicity earlier in the year when top tennis player Greg Rusedski tested positive for the steroid nandrolone as the result of inadvertent intake via a contaminated supplement. In this article, Professor Ron Maughan, Chair of Sports Nutrition at Loughborough University in the United Kingdom, advisor to the British Olympic team, and co-editor of IJSNEM, provides his insight on this important topic.

Enhancing students’ cognitive skill in Nguyen Tat Thanh high school Hanoi Vietnam through scientific learning material of static electricity

Science.gov (United States)

Priyanto, A.; Linuwih, S.; Aji, M. P.; Bich, D. D.

2018-03-01

Scientific learning material is still needed by students at Nguyen Tat Thanh High School (NTT), Hanoi Vietnam in order to enhance the students’ cognitive skill. Cognitive skill represents the level of students’ understanding to the particular material. Students’ cognitive skill can be improved by applying the learning material based on scientific approach as a treatment. The enhancement of students’ cognitive skill can be measured by analyzing the students’ test result collected before and after treatment. The analysis is focused to measure the enhancement or the sifted of cognitive aspects including remembering aspect (C1), understanding aspect (C2), applying aspect (C3), analyzing aspect (C4), and evaluating aspect (C5). According to the analysis the enhancement of cognitive aspects are 8.26% of remembering, 3.26% of understanding, 32.94% of applying, 21.74% of analyzing, and 21.74% of evaluating. The major enhancements are occured at applying, analyzing, and evaluating aspects. Therefore it can be concluded that students’ cognitive skill is enhanced by applying scientific learning material of static electricity.

Immunization with the Malaria Diversity-Covering Blood-Stage Vaccine Candidate Plasmodium falciparum Apical Membrane Antigen 1 DiCo in Complex with Its Natural Ligand PfRon2 Does Not Improve the In Vitro Efficacy

Directory of Open Access Journals (Sweden)

Holger Spiegel

2017-06-01

Full Text Available The blood-stage malaria vaccine candidate Plasmodium falciparum apical membrane antigen 1 (PfAMA1 can induce strong parasite growth-inhibitory antibody responses in animals but has not achieved the anticipated efficacy in clinical trials. Possible explanations in humans are the insufficient potency of the elicited antibody responses, as well as the high degree of sequence polymorphisms found in the field. Several strategies have been developed to improve the cross-strain coverage of PfAMA1-based vaccines, whereas innovative concepts to increase the potency of PfAMA1-specific IgG responses have received little attention even though this may be an essential requirement for protective efficacy. A previous study has demonstrated that immunization with a complex of PyAMA1 and PyRON2, a ligand with an essential functional role in erythrocyte invasion, leads to protection from lethal Plasmodium yoelli challenge in an animal model and suggested to extend this strategy toward improved strain coverage by using multiple PfAMA1 alleles in combination with PfRon2L. As an alternative approach along this line, we decided to use PfRon2L in combination with three PfAMA1 diversity covering variants (DiCo to investigate the potential of this complex to induce more potent parasite growth inhibitory immune response in combination with better cross-strain-specific efficacy. Within the limits of the study design, the ability of the PfAMA1 DiCo-Mix to induce cross-strain-specific antibodies was not affected in all immunization groups, but the DiCo–PfRon2L complexes did not improve the potency of PfAMA1-specific IgG responses.

Engine performance testing using variable RON95 fuel brands available in Malaysia

Directory of Open Access Journals (Sweden)

Mohd Riduan Aizuddin Fahmi

2017-01-01

Full Text Available There are various gasoline fuel producers available in Malaysia. The effects of fuel variations from different manufacturers on vehicle performance have always been a debate among users and currently the facts still remains inconclusive. Hence, this study focuses on analyzing various RON95 fuel brands available in the Malaysian market and finding the differences towards engine performance. In terms of engine output, the important data of power (hp and torque (Nm will be gathered by using an engine dynamometer. Another data that would also be taken into account is the knocking where the relative knock index can be measured in percentage using the knock sensor accelerometer. Results have shown that the performance of different fuel brands tested are indeed different albeit by only a small margin even though all fuels are categorized with the same octane rating. The power and torque results also imply that both are influenced by the amount of vibration generated due to engine knocking. Based from the overall outcome, consumers would not need to only focus on a certain type of gasoline brand as all differentiates the engine performance marginally.

Land use changes assessment using spatial data: Case study in Cong river basin - Thai Nguyen City - Viet Nam

Science.gov (United States)

Nguyen, Hieu

Land use changes are being interested in most countries, especially in developing countries. Because land use changes always impacts on sustainable development not only in a region or a country but also in whole the world. Viet Nam is a developing country, in the last 10 years, land uses have rapidly changed in most provinces. Many of agriculture areas, forest areas have changed for various purposes as urban sprawl, establishing new industrial parks, public areas, mining and other land uses relate to human activities or economic function associated with a specific piece of land. Beside efficiencies of economic and society, then environment issues have been threatening serious pollution, are from land use changes. Remote sensing images application on studying land use changes, has been done in many countries around the world, and has brought high efficiencies. However, this application is still very new and limited in Viet Nam due to lacking of materials, tools, experts of remote sensing. This study used spatial data as Landsat TM images, SPOT5 images and land use planning maps to rapidly assess on happenings of land uses in the period 2000 -2010 in Cong river basin (Thai Nguyen City, Viet Nam), and to forecast the changes of land uses in the period 2010 - 2020. The results had a good accuracy and to be important references for authorities, policy makers in local land use.

Effect of Coarse Particle Volume Fraction on the Yield Stress of Muddy Sediments from Marennes Oléron Bay

Directory of Open Access Journals (Sweden)

A. Pantet

2010-01-01

Full Text Available Coastal erosion results from a combination of various factors, both natural and humaninduced, which have different time and space patterns. In addition, uncertainties still remain about the interactions of the forcing agents, as well as on the significance of non-local causes of erosion. We focused about the surface sediments in the Marennes Oléron bay, after a general description of the site that has many various activities. The superficial sediments show a mechanical behavior, mainly depends on the fine fraction for a composition that contains up to 60% of sandy material. Fine sediments fraction has a typical yield stress depending naturally of concentration or water content. This yield could be modified slightly or significantly by adding silt or sand. As a result, the rheological measurement sensitivity allows us to characterize five typical sediments that correlate with solid fraction and fine fraction.

Community-level income inequality and HIV prevalence among persons who inject drugs in Thai Nguyen, Vietnam.

Science.gov (United States)

Lim, Travis W; Frangakis, Constantine; Latkin, Carl; Ha, Tran Viet; Minh, Nguyen Le; Zelaya, Carla; Quan, Vu Minh; Go, Vivian F

2014-01-01

Socioeconomic status has a robust positive relationship with several health outcomes at the individual and population levels, but in the case of HIV prevalence, income inequality may be a better predictor than absolute level of income. Most studies showing a relationship between income inequality and HIV have used entire countries as the unit of analysis. In this study, we examine the association between income inequality at the community level and HIV prevalence in a sample of persons who inject drugs (PWID) in a concentrated epidemic setting. We recruited PWID and non-PWID community participants in Thai Nguyen, Vietnam, and administered a cross-sectional questionnaire; PWID were tested for HIV. We used ecologic regression to model HIV burden in our PWID study population on GINI indices of inequality calculated from total reported incomes of non-PWID community members in each commune. We also modeled HIV burden on interaction terms between GINI index and median commune income, and finally used a multi-level model to control for community level inequality and individual level income. HIV burden among PWID was significantly correlated with the commune GINI coefficient (r = 0.53, p = 0.002). HIV burden was also associated with GINI coefficient (β = 0.082, p = 0.008) and with median commune income (β = -0.018, p = 0.023) in ecological regression. In the multi-level model, higher GINI coefficient at the community level was associated with higher odds of individual HIV infection in PWID (OR = 1.46 per 0.01, p = 0.003) while higher personal income was associated with reduced odds of infection (OR = 0.98 per $10, p = 0.022). This study demonstrates a context where income inequality is associated with HIV prevalence at the community level in a concentrated epidemic. It further suggests that community level socioeconomic factors, both contextual and compositional, could be indirect determinants of HIV infection in PWID.

Community-Level Income Inequality and HIV Prevalence among Persons Who Inject Drugs in Thai Nguyen, Vietnam

Science.gov (United States)

Lim, Travis W.; Frangakis, Constantine; Latkin, Carl; Ha, Tran Viet; Minh, Nguyen Le; Zelaya, Carla; Quan, Vu Minh; Go, Vivian F.

2014-01-01

Socioeconomic status has a robust positive relationship with several health outcomes at the individual and population levels, but in the case of HIV prevalence, income inequality may be a better predictor than absolute level of income. Most studies showing a relationship between income inequality and HIV have used entire countries as the unit of analysis. In this study, we examine the association between income inequality at the community level and HIV prevalence in a sample of persons who inject drugs (PWID) in a concentrated epidemic setting. We recruited PWID and non-PWID community participants in Thai Nguyen, Vietnam, and administered a cross-sectional questionnaire; PWID were tested for HIV. We used ecologic regression to model HIV burden in our PWID study population on GINI indices of inequality calculated from total reported incomes of non-PWID community members in each commune. We also modeled HIV burden on interaction terms between GINI index and median commune income, and finally used a multi-level model to control for community level inequality and individual level income. HIV burden among PWID was significantly correlated with the commune GINI coefficient (r = 0.53, p = 0.002). HIV burden was also associated with GINI coefficient (β = 0.082, p = 0.008) and with median commune income (β = −0.018, p = 0.023) in ecological regression. In the multi-level model, higher GINI coefficient at the community level was associated with higher odds of individual HIV infection in PWID (OR = 1.46 per 0.01, p = 0.003) while higher personal income was associated with reduced odds of infection (OR = 0.98 per $10, p = 0.022). This study demonstrates a context where income inequality is associated with HIV prevalence at the community level in a concentrated epidemic. It further suggests that community level socioeconomic factors, both contextual and compositional, could be indirect determinants of HIV infection in PWID. PMID

Management of patients under general anesthesia with mafutsu-san in Hanaoka-style surgery: comparisons of illustrations from Geka-Kihai-Zufu with descriptions from Mafutsuto-Ron and Yohka-Hiroku.

Science.gov (United States)

Dote, Kentaro; Yorozuya, Tosihiro; Ikemune, Keizo; Desaki, Yoko

2015-02-01

Seishu Hanaoka (1760-1835) left behind no books that he himself had written. This is why many aspects of Hanaoka-style general anesthesia using a mixture of herbal extracts, which he called mafutsu-san, remain unknown. We are able to learn about this technique today because there are several descriptions of it in books written by his students, such as Mafutsuto-Ron ("Treatise on Mafutsuto") by Gendai Kamata (1794-1854) and Yohka-Hiroku ("Secret Records of Surgery") by Gencho Homma (1804-1872). On the other hand, Geka-Kihai-Zufu ("Illustrations of Surgical Cases"), a surgical textbook, by Gendai Kamata, containing one of the oldest illustrations of general anesthesia published in 1840, was recently rediscovered (2011). For the first time, this book revealed, in the form of a picture image, the actual circumstances of Hanaoka-style general anesthesia. We therefore compared the descriptions of general anesthesia featured in these three documents, and thereby investigated the actual anesthetic management and the procedures used. We found that the circumstances under which Hanaoka-style general anesthesia, using fabrics and futon mattresses, as well as blindfolding and constraining the patient's body during surgery, were exactly as described in Mafutsuto-Ron and Yohka-Hiroku. In addition, besides a surgeon conducting an operation, there was a physician who observed the patient's general condition. Gendai Kamata, the author of Geka-Kihai-Zufu, is believed to have recognized the importance of anesthetic care of surgical patients.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

hexylthiophene)- graft -carbon nanotubes with LiNi 0.5 Mn 1.5 O _4$ and its application as potential cathode materials for lithium-ion batteries · THANG VAN LE THU ANH NGUYEN NGUYET MINH THI NGUYEN ANH TUAN LUU LE-THU T NGUYEN HA ...

Turbulent burning characteristics of FACE-C gasoline and TPRF blend associated with the same RON at elevated pressures

KAUST Repository

Mannaa, Ossama

2018-04-06

Fuels for Advanced Combustion Engine (FACE)-C gasoline/air and toluene primary reference fuel (TPRF) (51.6 vol% iso-octane, 21.5 vol% n-heptane and 26.9 vol% toluene)/air mixtures corresponding to the same Research Octane numbers (RON) of 85 were characterized in terms of determining their burning rates in a fan stirred turbulent vessel and filmed using a high-speed dual Schlieren imaging technique. Also, a Mie scattering planar laser tomography was employed to characterize the variations of flame morphology induced by the simultaneous existences of different turbulent length scales and the susceptibility to develop cellular structures at elevated pressures (through the Darrieus-Landau instability). Measurements were performed in a well-controlled environment of initial pressures 0.1, 0.5 and 1.0 MPa at a fixed initial temperature of 358 K at a range of measured turbulence intensities from 0.5 to 2.0 m/s. The enhancement of turbulent burning velocity ST as a function of turbulence intensity was evaluated. The absence of bending regime was accounted for based on the size of the vessel and limited range of turbulent intensities investigated in the present work. All the present data were empirically correlated by power-law correlation derived for a different flame-type configuration to test its sensitivity to the geometry and type of the burner investigated.

Effects of short-term environmental disturbances on living benthic foraminifera during the Pacific oyster summer mortality in the Marennes-Oléron Bay (France).

Science.gov (United States)

Bouchet, Vincent M P; Debenay, Jean-Pierre; Sauriau, Pierre-Guy; Radford-Knoery, Joël; Soletchnik, Patrick

2007-09-01

Sediment cores were collected from April to August 2004 on tidal mudflats of the macrotidal Marennes-Oléron Bay (SW France), famous for the cultivation of Pacific oysters (Crassostrea gigas). The response of living (stained) benthic foraminifera to short-term biogeochemical disturbances in the sediment and overlying water, which may be involved in oyster summer mortality, was monitored. Short-term hypoxia occurred in early June, in conjunction with a sudden rise in temperature. In mid-June, the ammonia content of sediment porewater increased, leading to potentially maximal flux towards overlying waters. Foraminiferal assemblages, particularly in the topmost layer, were altered. Ammonia tepida was the most tolerant to temperature increase and hypoxic conditions whereas Brizalina variabilis and Haynesina germanica were sensitive to organic degradation and hypoxia. Cribroelphidium gunteri was the most opportunistic during recolonisation. Benthic foraminifera showed that short-term biochemical changes in the sediment are toxic and may be involved in the summer mortality of Pacific oysters.

Towards an Integrative Framework of Conflict-handling Behaviour

DEFF Research Database (Denmark)

Li, Xin; Worm, Verner; Xie, Peihong

2018-01-01

Following in the footsteps of Frances Brew and the late Kwok Leung (1958–2015), we attempt to further integrate the Western dual-concern model of conflict and the Chinese dual-motive model of harmony. Our integrative framework of conflict-handling behaviour is designed to be more comprehensive in...... to take a further step in the process of universalization of an indigenous Chinese theory.......Following in the footsteps of Frances Brew and the late Kwok Leung (1958–2015), we attempt to further integrate the Western dual-concern model of conflict and the Chinese dual-motive model of harmony. Our integrative framework of conflict-handling behaviour is designed to be more comprehensive...

Design of Experiment Approach to Hydrogen Re-embrittlement Evaluation WP-2152

Science.gov (United States)

2015-04-01

2152 by Scott M Grendahl, Hoang Nguyen, Franklin Kellogg , Shuying Zhu, and Stephen Jones Approved for public release...and Materials Research Directorate, ARL Hoang Nguyen and Franklin Kellogg Bowhead Science and Technology, LLC Shuying Zhu and Stephen Jones The...ELEMENT NUMBER 6. AUTHOR(S) Scott M Grendahl, Hoang Nguyen, Franklin Kellogg , Shuying Zhu, and Stephen Jones 5d. PROJECT NUMBER W74RDV20769717 5e

US Army Research Laboratory Lightweight and Specialty Metals Branch Research and Development (FY14)

Science.gov (United States)

2015-04-01

2014 Feb. Report No.: ARL-TR- 6807. 8) Grendahl SM, Kellogg F, Nguyen H. Effect of cleanliness on hydrogen toler- ance in high-strength steel...SJ, Kellogg F, Nguyen H, Runk D. Ul- trasonic shot peening for aviation components. Aberdeen Proving Ground (MD): Army Research Laboratory (US); 2013...M. Grendahl Weapons and Materials Research Directorate, ARL Franklyn Kellogg and Hoang Nguyen Bowhead Technical Services

Seven new species of Begonia (Begoniaceae) in Northern Vietnam and Southern China

Science.gov (United States)

Chen, Wen-Hong; Radbouchoom, Sirilak; Nguyen, Hieu Quang; Nguyen, Hiep Tien; Nguyen4, Khang Sinh; Shui, Yu-Min

2018-01-01

Abstract Since 2016, KIB (Kunming Institute of Botany) and CPC (Centre for Plant Conservation of Vietnam) have conducted several surveys in the transboundary karst regions in Northern Vietnam and Southern China and seven new species in the genus Begonia Linn. (Begoniaceae) are firstly described. Amongst them, two species, Begonia albopunctata Y.M. Shui, W.H. Chen & H.Q. Nguyen and B. erectocarpa H.Q. Nguyen, Y.M. Shui & W.H. Chen, respectively belong to section Sphenanthera with berry fruits and section Leprosae with clavate berry fruits; four species, B. gulongshanensis Y.M. Shui & W. H. Chen, B. minissima H.Q. Nguyen, Y.M. Shui & W.H. Chen, B. mollissima Y.M. Shui, H.Q. Nguyen & W.H. Chen, B. rhytidophylla Y.M. Shui & W.H. Chen, belong to section Coelocentrum with parietal placentation; one species, Begonia bambusetorum H.Q. Nguyen, Y.M. Shui & W.H. Chen, belongs to section Diploclinium with 3-loculed ovary and capsules. The diagnostic characters of these species are described and illustrated in the text and photographs. PMID:29416422

To the Issue of Application of L. Ron Hubbard Detoxication Method Under the Program of Semipalatinsk Region Population Rehabilitation

International Nuclear Information System (INIS)

Apusheva, B.K.; Nurumbetova, R.M.; Tuleubaev, B.A.

1998-01-01

The detoxification is one of the most acute problems of the population rehabilitation program of Semipalatinsk region suffered from the nuclear tests in 1949 - 1989. It is known that a Humanitarian Detoxification Service is success-fully functioning in Russia and facilitates the creation of improving centers for the removal of toxic chemical deposits, radiation decay products, and drugs out of the human organism. A method, which permits the successful removal of chemical deposits from the organism, consists of a number of procedures including the intake of a balanced amount of vitamins and minerals, physical exercises and sauna. It is based on the developments of an American scientist L. Ron Hubbard and analytical results of different biologists, physicians and pharmacologists. The effectiveness of the method was confirmed with the numerous clinical tests and examination of over 20,000 patients. The positive results were also obtained during the application of method to the people suffered from the Chernobyl accident. It is proposed to establish such detoxification centre in Kurchatov in order to perform similar investigations among the population of Semipalatinsk region affected by the nuclear testing. It will be created under the auspices of the Kazakh Detoxification Centre and the Pavlodar Centre of the Dianetika International Public Movement. The stable and successive functioning of the Centre is entirely dependent on the financing from the different funds and contract works. This paper proposes the ways of practical solution of man detoxification problem and the introduction of the method into the existing system of population rehabilitation

AMPK signaling in skeletal muscle during exercise: Role of reactive oxygen and nitrogen species.

Science.gov (United States)

Morales-Alamo, David; Calbet, Jose A L

2016-09-01

Reactive oxygen and nitrogen species (RONS) are generated during exercise depending on intensity, duration and training status. A greater amount of RONS is released during repeated high-intensity sprint exercise and when the exercise is performed in hypoxia. By activating adenosine monophosphate-activated kinase (AMPK), RONS play a critical role in the regulation of muscle metabolism but also in the adaptive responses to exercise training. RONS may activate AMPK by direct an indirect mechanisms. Directly, RONS may activate or deactivate AMPK by modifying RONS-sensitive residues of the AMPK-α subunit. Indirectly, RONS may activate AMPK by reducing mitochondrial ATP synthesis, leading to an increased AMP:ATP ratio and subsequent Thr(172)-AMPK phosphorylation by the two main AMPK kinases: LKB1 and CaMKKβ. In presence of RONS the rate of Thr(172)-AMPK dephosphorylation is reduced. RONS may activate LKB1 through Sestrin2 and SIRT1 (NAD(+)/NADH.H(+)-dependent deacetylase). RONS may also activate CaMKKβ by direct modification of RONS sensitive motifs and, indirectly, by activating the ryanodine receptor (Ryr) to release Ca(2+). Both too high (hypoxia) and too low (ingestion of antioxidants) RONS levels may lead to Ser(485)-AMPKα1/Ser(491)-AMPKα2 phosphorylation causing inhibition of Thr(172)-AMPKα phosphorylation. Exercise training increases muscle antioxidant capacity. When the same high-intensity training is applied to arm and leg muscles, arm muscles show signs of increased oxidative stress and reduced mitochondrial biogenesis, which may be explained by differences in RONS-sensing mechanisms and basal antioxidant capacities between arm and leg muscles. Efficient adaptation to exercise training requires optimal exposure to pulses of RONS. Inappropriate training stimulus may lead to excessive RONS formation, oxidative inactivation of AMPK and reduced adaptation or even maladaptation. Theoretically, exercise programs should be designed taking into account the

Individual-level socioeconomic status and community-level inequality as determinants of stigma towards persons living with HIV who inject drugs in Thai Nguyen, Vietnam.

Science.gov (United States)

Lim, Travis; Zelaya, Carla; Latkin, Carl; Quan, Vu Minh; Frangakis, Constantine; Ha, Tran Viet; Minh, Nguyen Le; Go, Vivian

2013-11-13

HIV infection may be affected by multiple complex socioeconomic status (SES) factors, especially individual socioeconomic disadvantage and community-level inequality. At the same time, stigma towards HIV and marginalized groups has exacerbated persistent concentrated epidemics among key populations, such as persons who inject drugs (PWID) in Vietnam. Stigma researchers argue that stigma fundamentally depends on the existence of economic power differences in a community. In rapidly growing economies like Vietnam, the increasing gap in income and education levels, as well as an individual's absolute income and education, may create social conditions that facilitate stigma related to injecting drug use and HIV. A cross-sectional baseline survey assessing different types of stigma and key socioeconomic characteristics was administered to 1674 PWID and 1349 community members living in physical proximity throughout the 32 communes in Thai Nguyen province, Vietnam. We created four stigma scales, including HIV-related and drug-related stigma reported by both PWID and community members. We then used ecologic Spearman's correlation, ordinary least-squares regression and multi-level generalized estimating equations to examine community-level inequality associations, individual-level SES associations and multi-level SES associations with different types of stigma, respectively. There was little urban-rural difference in stigma among communes. Higher income inequality was marginally associated with drug-related stigma reported by community members (p=0.087), and higher education inequality was significantly associated with higher HIV-related stigma reported by both PWID and community members (pinequality and HIV-related stigma is superseded by the effect of individual-level education. The results of the study confirm that socioeconomic factors at both the individual level and community level affect different types of stigma in different ways. Attention should be paid to these

CME 9060 (ONLINE).indd

African Journals Online (AJOL)

9789241547833_eng.pdf (accessed. 14 July 2014). 12. Thwaites GE, Nguyen DB, Nguyen HD, et al. Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults. N Engl J Med 2004;351:1741-1751. 13. Torok ME, Yen NT, Chau TT, ...

Can Retail Selling Prices of Petrol and Diesel Trigger Inflation in Malaysia?

Directory of Open Access Journals (Sweden)

Shaari Mohd Shahidan

2018-01-01

Full Text Available Previously, many studies explored the effects of oil price on inflation by using the price of crude oil as the proxy of oil price. The novelty of this current study is that it used several types of fuel prices including RON95, RON97 and Diesel. This study employed the ARDL approach and analysed the monthly data from 2010 to 2015 in Malaysia. The result shows that there are significant effects of the price of RON95, RON97 and diesel on inflation in the long run in Malaysia. However, in the short run, the price of RON97 does not affect inflation while the prices of RON95 and diesel do affect inflation in Malaysia.

El voleibol adaptado en la Educación Física de octavo grado de la escuela especial “Nguyen Van Troy” en Camagüey

Directory of Open Access Journals (Sweden)

Reinier Benítez Villalobos

2007-12-01

Full Text Available Los niños y jóvenes con retraso mental presentan deficiencias en la adquisición de hábitos y habilidades motrices además de limitaciones, desde el punto de vista psicomotriz, en la coordinación, simultaneidad de los movimientos, equilibrio estático, memoria motriz y otros indicadores. Ante esta situación este trabajo tiene como objetivo adecuar el Voleibol en la Educación Física para mejorar la psicomotricidad de los retrasados mentales de 8vo grado de la escuela “Nguyen Van Troi”; para ello se trabajó con la población de estudiantes del 8vo grado aplicándoles adaptaciones en el deporte (Voleibol. Para darle validez científica se utilizaron como métodos teóricos: el históricológico, análisis-síntesis, inductivo-deductivo; de los empíricos la medición, la entrevista como técnica y con predominio de la pre-experimentación; como estadísticos de la estadística descriptiva, la media, moda, mediana, desviación estándar, coeficiente de variación y el calculo porcentual; de la inferencial la prueba T de student o Wilcoxon con un rango de 0.05 para determinar si existieron cambios significativos, todo ello a través del SPSS 9.0 for Windows. Se pudo constatar que en el diagnóstico de las habilidades el pase por abajo fue la de mayores deficiencias, mientras que en los indicadores psicomotrices solo estaba aceptable la fuerza de brazos y con la aplicación de las adecuaciones curriculares se logró mejorar las habilidades, así como los indicadores psicomotrices, por lo que recomendamos continuar realizando adecuaciones en otros deportes objeto de estudios para una mejor corrección y compensación de los niños con retraso mental.

Social marketing of low dead space syringes in Vietnam: findings from a 1-year pilot program in Hanoi, Thai Nguyen, and Ho Chi Minh City.

Science.gov (United States)

Huong, Ngo Thi Thanh; Mundy, Gary; Neukom, Josselyn; Zule, William; Tuan, Nguyen Minh; Tam, Nguyen Minh

2015-05-30

Although a growing body of evidence suggests that low dead space syringes may reduce the risk of human immunodeficiency virus (HIV) and Hepatitis C virus infection associated with sharing syringes among people who inject drugs, there is little evidence of effective approaches to motivate people who inject drugs (PWID) to shift from high to low dead space syringes. Using a mix of consumer and trade marketing approaches, informed by rapid assessments of both the syringe market and PWID preferences, practices, and behaviors in Hanoi and Ho Chi Minh City, Population Services International (PSI) Vietnam piloted an intervention to increase the use of low dead space syringes (LDSS) in the three provinces of Hanoi, Ho Chi Minh City, and Thai Nguyen, where an estimated 31% of PWID are HIV positive and 58% are living with hepatitis C virus (HCV). This paper provides a summary of the social marketing activities implemented and results achieved by PSI Vietnam during an initial 1-year pilot period from December 2012 to December 2013 in these three provinces to explore their effectiveness in motivating PWID to use low dead space syringes. We found major increases in sales of LDSS accompanied by increases in reported use and consistent use of LDSS among PWID in the three provinces included in the pilot program and a positive and independent association (odds ratio (OR) 21.08; 95% confidence interval (CI) 10.6-27.3) between LDSS use and exposure to social marketing activities. We also found that LDSS use had a stronger association with perceptions of LDSS product quality than with perceptions regarding LDSS potential to reduce HIV transmission risk and use. We conclude that social marketing interventions have an important role to play in widening access to and the use of LDSS for PWID, as they address the need for PWID to find LDSS when and where they need them and also promote the benefits of LDSS use to PWID. High coverage of these activities among PWID appears to be the key in

Refining economics of U.S. gasoline: octane ratings and ethanol content.

Science.gov (United States)

Hirshfeld, David S; Kolb, Jeffrey A; Anderson, James E; Studzinski, William; Frusti, James

2014-10-07

Increasing the octane rating of the U.S. gasoline pool (currently ∼ 93 Research Octane Number (RON)) would enable higher engine efficiency for light-duty vehicles (e.g., through higher compression ratio), facilitating compliance with federal fuel economy and greenhouse gas (GHG) emissions standards. The federal Renewable Fuels Standard calls for increased renewable fuel use in U.S. gasoline, primarily ethanol, a high-octane gasoline component. Linear programming modeling of the U.S. refining sector was used to assess the effects on refining economics, CO2 emissions, and crude oil use of increasing average octane rating by increasing (i) the octane rating of refinery-produced hydrocarbon blendstocks for oxygenate blending (BOBs) and (ii) the volume fraction (Exx) of ethanol in finished gasoline. The analysis indicated the refining sector could produce BOBs yielding finished E20 and E30 gasolines with higher octane ratings at modest additional refining cost, for example, ∼ 1¢/gal for 95-RON E20 or 97-RON E30, and 3-5¢/gal for 95-RON E10, 98-RON E20, or 100-RON E30. Reduced BOB volume (from displacement by ethanol) and lower BOB octane could (i) lower refinery CO2 emissions (e.g., ∼ 3% for 98-RON E20, ∼ 10% for 100-RON E30) and (ii) reduce crude oil use (e.g., ∼ 3% for 98-RON E20, ∼ 8% for 100-RON E30).

ROTUNDA3 function in plant development by phosphatase 2A-mediated regulation of auxin transporter recycling.

Science.gov (United States)

Karampelias, Michael; Neyt, Pia; De Groeve, Steven; Aesaert, Stijn; Coussens, Griet; Rolčík, Jakub; Bruno, Leonardo; De Winne, Nancy; Van Minnebruggen, Annemie; Van Montagu, Marc; Ponce, María Rosa; Micol, José Luis; Friml, Jiří; De Jaeger, Geert; Van Lijsebettens, Mieke

2016-03-08

The shaping of organs in plants depends on the intercellular flow of the phytohormone auxin, of which the directional signaling is determined by the polar subcellular localization of PIN-FORMED (PIN) auxin transport proteins. Phosphorylation dynamics of PIN proteins are affected by the protein phosphatase 2A (PP2A) and the PINOID kinase, which act antagonistically to mediate their apical-basal polar delivery. Here, we identified the ROTUNDA3 (RON3) protein as a regulator of the PP2A phosphatase activity in Arabidopsis thaliana. The RON3 gene was map-based cloned starting from the ron3-1 leaf mutant and found to be a unique, plant-specific gene coding for a protein with high and dispersed proline content. The ron3-1 and ron3-2 mutant phenotypes [i.e., reduced apical dominance, primary root length, lateral root emergence, and growth; increased ectopic stages II, IV, and V lateral root primordia; decreased auxin maxima in indole-3-acetic acid (IAA)-treated root apical meristems; hypergravitropic root growth and response; increased IAA levels in shoot apices; and reduced auxin accumulation in root meristems] support a role for RON3 in auxin biology. The affinity-purified PP2A complex with RON3 as bait suggested that RON3 might act in PIN transporter trafficking. Indeed, pharmacological interference with vesicle trafficking processes revealed that single ron3-2 and double ron3-2 rcn1 mutants have altered PIN polarity and endocytosis in specific cells. Our data indicate that RON3 contributes to auxin-mediated development by playing a role in PIN recycling and polarity establishment through regulation of the PP2A complex activity.

Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.

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Steven E Kauder

Full Text Available Macrophage stimulating protein (MSP is a serum growth factor that binds to and activates the receptor tyrosine kinase, Recepteur d'Origine Nantais (RON. A non-synonymous coding variant in MSP (689C has been associated with genetic susceptibility to both Crohn's disease and ulcerative colitis, two major types of inflammatory bowel disease (IBD characterized by chronic inflammation of the digestive tract. We investigated the consequences of this polymorphism for MSP-RON pathway activity and IBD pathogenesis.RON expression patterns were examined on mouse and human cells and tissues under normal and disease conditions to identify cell types regulated by MSP-RON. Recombinant MSP variants were tested for their ability to bind and stimulate RON and undergo proteolytic activation. MSP concentrations were quantified in the serum of individuals carrying the MSP 689R and 689C alleles.In intestinal tissue, RON was primarily expressed by epithelial cells under normal and disease conditions. The 689C polymorphism had no impact on the ability of MSP to bind to or signal through RON. In a cohort of normal individuals and IBD patients, carriers of the 689C polymorphism had lower concentrations of MSP in their serum.By reducing the quantities of circulating MSP, the 689C polymorphism, or a variant in linkage disequilibrium with this polymorphism, may impact RON ligand availability and thus receptor activity. Given the known functions of RON in regulating wound healing and our analysis of RON expression patterns in human intestinal tissue, these data suggest that decreased RON activity may impact the efficiency of epithelial repair and thus underlie the increased IBD susceptibility associated with the MSP 689C allele.

Identifying High-Traffic Patterns in the Workplace with Radio Tomographic Imaging in 3D Wireless Sensor Networks

Science.gov (United States)

2014-03-27

more likely to employ ad-hoc networks, such as in emergency and military situations when timeliness and multitasking is of the essence. The...Tristan Nguyen, AFOSR/RTC) Comm. Phone: (703) 696-7796 / DSN: 426-7796 / Fax: (703) 696-7360 Email : tristan.nguyen@afosr.af.mil 875 North Randolph Street

Individual-level socioeconomic status and community-level inequality as determinants of stigma towards persons living with HIV who inject drugs in Thai Nguyen, Vietnam

Science.gov (United States)

Lim, Travis; Zelaya, Carla; Latkin, Carl; Quan, Vu Minh; Frangakis, Constantine; Ha, Tran Viet; Minh, Nguyen Le; Go, Vivian

2013-01-01

Introduction HIV infection may be affected by multiple complex socioeconomic status (SES) factors, especially individual socioeconomic disadvantage and community-level inequality. At the same time, stigma towards HIV and marginalized groups has exacerbated persistent concentrated epidemics among key populations, such as persons who inject drugs (PWID) in Vietnam. Stigma researchers argue that stigma fundamentally depends on the existence of economic power differences in a community. In rapidly growing economies like Vietnam, the increasing gap in income and education levels, as well as an individual's absolute income and education, may create social conditions that facilitate stigma related to injecting drug use and HIV. Methods A cross-sectional baseline survey assessing different types of stigma and key socioeconomic characteristics was administered to 1674 PWID and 1349 community members living in physical proximity throughout the 32 communes in Thai Nguyen province, Vietnam. We created four stigma scales, including HIV-related and drug-related stigma reported by both PWID and community members. We then used ecologic Spearman's correlation, ordinary least-squares regression and multi-level generalized estimating equations to examine community-level inequality associations, individual-level SES associations and multi-level SES associations with different types of stigma, respectively. Results There was little urban–rural difference in stigma among communes. Higher income inequality was marginally associated with drug-related stigma reported by community members (p=0.087), and higher education inequality was significantly associated with higher HIV-related stigma reported by both PWID and community members (pstigma (HIV and drug related) reported by both PWID and community members. Part-time employed PWID reported more experiences and perceptions of drug-related stigma, while conversely unemployed community members reported enacting lower drug-related stigma

Fulltext PDF

Indian Academy of Sciences (India)

Kwok W Chow, Department of Mechanical Engineering, University of Hong Kong, Pokfulam. Road, Hong Kong kwchow@hkusua.hku.hk. P L Chu, Optical Communications Group, School of Electrical Engineering and Telecommunica- tions, University of New South Wales, Sydney 2052, Australia. Lucian-Cornel Crasovan ...

A novel planar vertical double-diffused metal-oxide-semiconductor field-effect transistor with inhomogeneous floating islands

Institute of Scientific and Technical Information of China (English)

Ren Min; Li Ze-Hong; Liu Xiao-Long; Xie Jia-Xiong; Deng Guang-Min; Zhang Bo

2011-01-01

A novel planar vertical double-diffused metal-oxide-semiconductor (VDMOS) structure with an ultra-low specific on-resistance (Ron,sp),whose distinctive feature is the use of inhomogeneous floating p-islands in the n-drift region,is proposed.The theoretical limit of its Ron,sp is deduced,the influence of structure parameters on the breakdown voltage (BV) and Ron,sp are investigated,and the optimized results with BV of 83 V and Ron,sp of 54 mΩ.mm2 are obtained.Simulations show that the inhomogencous-floating-islands metal-oxide-semiconductor field-effect transistor (MOSFET)has a superior “Ron,sp/BV” trade-off to the conventional VDMOS (a 38％ reduction of Ron,sp with the same BV) and the homogeneous-floating-islands MOSFET (a 10％ reduction of Ron,sp with the same BV).The inhomogeneous-floatingislands MOSFET also has a much better body-diode characteristic than the superjunction MOSFET.Its reverse recovery peak current,reverse recovery time and reverse recovery charge are about 50,80 and 40％ of those of the superjunction MOSFET,respectively.

Effects of an HIV peer prevention intervention on sexual and injecting risk behaviors among injecting drug users and their risk partners in Thai Nguyen, Vietnam: a randomized controlled trial.

Science.gov (United States)

Go, Vivian F; Frangakis, Constantine; Le Minh, Nguyen; Latkin, Carl A; Ha, Tran Viet; Mo, Tran Thi; Sripaipan, Teerada; Davis, Wendy; Zelaya, Carla; Vu, Pham The; Chen, Yong; Celentano, David D; Quan, Vu Minh

2013-11-01

Globally, 30% of new HIV infections outside sub-Saharan Africa involve injecting drug users (IDU) and in many countries, including Vietnam, HIV epidemics are concentrated among IDU. We conducted a randomized controlled trial in Thai Nguyen, Vietnam, to evaluate whether a peer oriented behavioral intervention could reduce injecting and sexual HIV risk behaviors among IDU and their network members. 419 HIV-negative index IDU aged 18 years or older and 516 injecting and sexual network members were enrolled. Each index participant was randomly assigned to receive a series of six small group peer educator-training sessions and three booster sessions in addition to HIV testing and counseling (HTC) (intervention; n = 210) or HTC only (control; n = 209). Follow-up, including HTC, was conducted at 3, 6, 9 and 12 months post-intervention. The proportion of unprotected sex dropped significantly from 49% to 27% (SE (difference) = 3%, p < 0.01) between baseline and the 3-month visit among all index-network member pairs. However, at 12 months, post-intervention, intervention participants had a 14% greater decline in unprotected sex relative to control participants (Wald test = 10.8, df = 4, p = 0.03). This intervention effect is explained by trial participants assigned to the control arm who missed at least one standardized HTC session during follow-up and subsequently reported increased unprotected sex. The proportion of observed needle/syringe sharing dropped significantly between baseline and the 3-month visit (14% vs. 3%, SE (difference) = 2%, p < 0.01) and persisted until 12 months, but there was no difference across trial arms (Wald test = 3.74, df = 3, p = 0.44). Copyright © 2013 Elsevier Ltd. All rights reserved.

Structural and functional insights into the malaria parasite moving junction complex.

Directory of Open Access Journals (Sweden)

Brigitte Vulliez-Le Normand

Full Text Available Members of the phylum Apicomplexa, which include the malaria parasite Plasmodium, share many features in their invasion mechanism in spite of their diverse host cell specificities and life cycle characteristics. The formation of a moving junction (MJ between the membranes of the invading apicomplexan parasite and the host cell is common to these intracellular pathogens. The MJ contains two key parasite components: the surface protein Apical Membrane Antigen 1 (AMA1 and its receptor, the Rhoptry Neck Protein (RON complex, which is targeted to the host cell membrane during invasion. In particular, RON2, a transmembrane component of the RON complex, interacts directly with AMA1. Here, we report the crystal structure of AMA1 from Plasmodium falciparum in complex with a peptide derived from the extracellular region of PfRON2, highlighting clear specificities of the P. falciparum RON2-AMA1 interaction. The receptor-binding site of PfAMA1 comprises the hydrophobic groove and a region that becomes exposed by displacement of the flexible Domain II loop. Mutations of key contact residues of PfRON2 and PfAMA1 abrogate binding between the recombinant proteins. Although PfRON2 contacts some polymorphic residues, binding studies with PfAMA1 from different strains show that these have little effect on affinity. Moreover, we demonstrate that the PfRON2 peptide inhibits erythrocyte invasion by P. falciparum merozoites and that this strong inhibitory potency is not affected by AMA1 polymorphisms. In parallel, we have determined the crystal structure of PfAMA1 in complex with the invasion-inhibitory peptide R1 derived by phage display, revealing an unexpected structural mimicry of the PfRON2 peptide. These results identify the key residues governing the interactions between AMA1 and RON2 in P. falciparum and suggest novel approaches to antimalarial therapeutics.

Export of a Toxoplasma gondii rhoptry neck protein complex at the host cell membrane to form the moving junction during invasion.

Directory of Open Access Journals (Sweden)

Sébastien Besteiro

2009-02-01

Full Text Available One of the most conserved features of the invasion process in Apicomplexa parasites is the formation of a moving junction (MJ between the apex of the parasite and the host cell membrane that moves along the parasite and serves as support to propel it inside the host cell. The MJ was, up to a recent period, completely unknown at the molecular level. Recently, proteins originated from two distinct post-Golgi specialised secretory organelles, the micronemes (for AMA1 and the neck of the rhoptries (for RON2/RON4/RON5 proteins, have been shown to form a complex. AMA1 and RON4 in particular, have been localised to the MJ during invasion. Using biochemical approaches, we have identified RON8 as an additional member of the complex. We also demonstrated that all RON proteins are present at the MJ during invasion. Using metabolic labelling and immunoprecipitation, we showed that RON2 and AMA1 were able to interact in the absence of the other members. We also discovered that all MJ proteins are subjected to proteolytic maturation during trafficking to their respective organelles and that they could associate as non-mature forms in vitro. Finally, whereas AMA1 has previously been shown to be inserted into the parasite membrane upon secretion, we demonstrated, using differential permeabilization and loading of RON-specific antibodies into the host cell, that the RON complex is targeted to the host cell membrane, where RON4/5/8 remain associated with the cytoplasmic face. Globally, these results point toward a model of MJ organization where the parasite would be secreting and inserting interacting components on either side of the MJ, both at the host and at its own plasma membranes.

Adaptation linguistique et culturelle: L'experience des refugies d'Asie du sud-est au Quebec (Linguistic and Cultural Adaptation: The Experience of Southeast Asian Refugees in Quebec).

Science.gov (United States)

Chan, Kwok B.; Dorais, Louis-Jacques

A collection of papers, in English and French, on the adjustment processes and problems of Southeast Asian refugees in Quebec includes: "Prelude to Resettlement: A Clinical View on the Transit Camp Experience of Vietnamese Refugees" (David Loveridge, Kwok B. Chan); "Une communaute culturelle en situation de diglossie: Les…

SAF-RON GOLD

Science.gov (United States)

Technical product bulletin: this dispersant used in oil spill cleanups can be applied by aerial or boat sprayer. A recommended dispersant to water ratio of 1:40 can be used for most spills. Ratios are dependent upon type of oil and weather conditions.

Elevated Building Lift Systems on Permanent Snowfields: A Report on the Elevated Building Lift Systems in Polar Environments Workshop

Science.gov (United States)

2014-09-18

Division. The Deputy Director of ERDC-CRREL was Dr. Lance Hansen, and the Director was Dr. Robert Davis. The authors wish to acknowledge those who made...Cold Regions Research and Engineering Laboratory. Kwok, K. C. S., D. J. Smedley , and D. H. Kim. 1993. Snowdrift around Antarctic buildings—effects of

Supporting the Reuse of Open Educational Resources through Open Standards

NARCIS (Netherlands)

Glahn, Christian; Kalz, Marco; Gruber, Marion; Specht, Marcus

2010-01-01

Glahn, C., Kalz, M., Gruber, M., & Specht, M. (2010). Supporting the Reuse of Open Educational Resources through Open Standards. In T. Hirashima, A. F. Mohd Ayub, L. F. Kwok, S. L. Wong, S. C. Kong, & F. Y. Yu (Eds.), Workshop Proceedings of the 18th International Conference on Computers in

Sequence Variation in Rhoptry Neck Protein 10 Gene among Toxoplasma gondii Isolates from Different Hosts and Geographical Locations

Directory of Open Access Journals (Sweden)

Yu ZHAO

2017-09-01

Full Text Available Background: Toxoplasma gondii, as a eukaryotic parasite of the phylum Apicomplexa, can infect almost all the warm-blooded animals and humans, causing toxoplasmosis. Rhoptry neck proteins (RONs play a key role in the invasion process of T. gondii and are potential vaccine candidate molecules against toxoplasmosis.Methods: The present study examined sequence variation in the rhoptry neck protein 10 (TgRON10 gene among 10 T. gondii isolates from different hosts and geographical locations from Lanzhou province during 2014, and compared with the corresponding sequences of strains ME49 and VEG obtained from the ToxoDB database, using polymerase chain reaction (PCR amplification, sequence analysis, and phylogenetic reconstruction by Bayesian inference (BI and maximum parsimony (MP. Results: Analysis of all the 12 TgRON10 genomic and cDNA sequences revealed 7 exons and 6 introns in the TgRON10 gDNA. The complete genomic sequence of the TgRON10 gene ranged from 4759 bp to 4763 bp, and sequence variation was 0-0.6% among the 12 T. gondii isolates, indicating a low sequence variation in TgRON10 gene. Phylogenetic analysis of TgRON10 sequences showed that the cluster of the 12 T. gondii isolates was not completely consistent with their respective genotypes.Conclusion: TgRON10 gene is not a suitable genetic marker for the differentiation of T. gondii isolates from different hosts and geographical locations, but may represent a potential vaccine candidate against toxoplasmosis, worth further studies.

Sequence Variation in Rhoptry Neck Protein 10 Gene among Toxoplasma gondii Isolates from Different Hosts and Geographical Locations.

Science.gov (United States)

Zhao, Yu; Zhou, Donghui; Chen, Jia; Sun, Xiaolin

2017-01-01

Toxoplasma gondii, as a eukaryotic parasite of the phylum Apicomplexa, can infect almost all the warm-blooded animals and humans, causing toxoplasmosis. Rhoptry neck proteins (RONs) play a key role in the invasion process of T. gondii and are potential vaccine candidate molecules against toxoplasmosis. The present study examined sequence variation in the rhoptry neck protein 10 (TgRON10) gene among 10 T. gondii isolates from different hosts and geographical locations from Lanzhou province during 2014, and compared with the corresponding sequences of strains ME49 and VEG obtained from the ToxoDB database, using polymerase chain reaction (PCR) amplification, sequence analysis, and phylogenetic reconstruction by Bayesian inference (BI) and maximum parsimony (MP). Analysis of all the 12 TgRON10 genomic and cDNA sequences revealed 7 exons and 6 introns in the TgRON10 gDNA. The complete genomic sequence of the TgRON10 gene ranged from 4759 bp to 4763 bp, and sequence variation was 0-0.6% among the 12 T. gondii isolates, indicating a low sequence variation in TgRON10 gene. Phylogenetic analysis of TgRON10 sequences showed that the cluster of the 12 T. gondii isolates was not completely consistent with their respective genotypes. TgRON10 gene is not a suitable genetic marker for the differentiation of T. gondii isolates from different hosts and geographical locations, but may represent a potential vaccine candidate against toxoplasmosis, worth further studies.

75 FR 69160 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

Science.gov (United States)

2010-11-10

... Kendall Teresa Kennedy Christin Susan Kim Chung H. Kim Hannah Boyoung Kim Johnny Han Kin Tse Wing Kiresepi... Ronald Lao Man Bee Lao Ruperto C. Laty Fabrice S. Lau Kwok Chu Lau Lawrence Juen-Yee Lau Megan Shirley... Po Polly Tsangrides Philippos Alexandros Tse Anthony Wai Chung Tse Christopher Tung Alan Leih-Sing...

Is Military Deployment a Risk Factor for Maternal Depression?

Science.gov (United States)

2013-01-01

679–684. 39. Quevedo LA, Silva RA, Godoy R, et al. The impact of ma- ternal post - partum depression on the language development of children at 12 months...Naval Health Research Center Is Military Deployment A Risk Factor for Maternal Depression ? Stacie Nguyen Cynthia A. LeardMann Besa Smith...Sylvester Road San Diego, California 92106-3521 Original Articles Is Military Deployment a Risk Factor for Maternal Depression ? Stacie Nguyen, MPH

Fundamental Limits of Delay and Security in Device-to-Device Communication

Science.gov (United States)

2013-01-01

max xl∈X l [ 1 l l∑ t=1 d(xt, X̂it) ] ≥ n− 1 n = 1− 1 n . This completes the proof. A.3 Proof of Theorem 4 IfR ′ < Rk(Dk), then the sum rate of any k...Nguyen, T. Nguyen, and S. Cheung, “Peer-to-Peer Streaming with Hier- archical Network Coding,” in Proc. IEEE ICME, Beijing, China , pp. 396-399, July

Assessing Two Theoretical Frameworks of Civic Engagement

Science.gov (United States)

García-Cabrero, Benilde; Pérez-Martínez, María Guadalupe; Sandoval-Hernández, Andrés; Caso-Niebla, Joaquín; Díaz-López, Carlos David

2016-01-01

The purpose of this study was to empirically test two major theoretical models: a modified version of the social capital model (Pattie, Seyd and Whiteley, 2003), and the Informed Social Engagement Model (Barr and Selman, 2014; Selman and Kwok, 2010), to explain civic participation and civic knowledge of adolescents from Chile, Colombia and Mexico,…

EXCHANGE RATE VS. INTEREST RATE: HOW MUCH DOES UIP WORK FOR ROMANIA? (STUDY CASE ON THE EUR/RON CURRENCY

Directory of Open Access Journals (Sweden)

Haulica Dana

2015-07-01

Full Text Available This paper is part of a larger research that aims to analyze the deviation between the Real Exchange Rate and the Equilibrium Exchange Rate in Romania (EUR/RON currency and to come up with conclusions regarding this deviation and with solutions to minimize it, if the case. Because this is the most important discussion after having the empirical results: what do emergent markets like Romania need to do to keep up with the EU trend? Which are the concessions they have to make in order to maintain a sustainable growth? Do these concessions include breaking the present equilibrium for a future BETTER? Starting with the most well-known methods to calculate the Equilibrium Exchange Rate, this article`s purpose is to create an accurate overview on the UIP model in Romania (the interest rate differential, to verify, using the latest data if the economic environment has brought any changes on the results of this model in the latest years. Is the UIP model a trustworthy equation to establish the Equilibrium Exchange Rate? In order to verify if the UIP model was more reliable in returning a value for the Equilibrium Exchange rate in the latest years on the Romanian market, this paper presents an empirical study containing recent compiled data from the last 10 years, analyzing the 2005 – 2014 period. The NEW in this article is that the used data is very fresh, currently, most probably the only study that verifies the UIP model in Romania for this specific period of time. Why is it useful? Why is it important? Because it doesn`t only bring a confirmation of weather the UIP works for Romania or not but comes up with hints and conclusions regarding the current economic situation of Romania. We can see what has been changed in the local market in the last ten years in terms of monetary policy and what has this change brought with it – if the results are those expected or not and also, what would be the direction for the next years – to most suitable

Radiation optic neuropathy after external beam radiation therapy for acromegaly: report of two cases

International Nuclear Information System (INIS)

Bergh, Alfons C.M. van den; Hoving, Marjanke A.; Links, Thera P.; Dullaart, Robin P.F.; Ranchor, Adelita V.; Weeme, Cees A. ter; Canrinus, Alof A.; Szabo, Ben G.; Pott, Jan-Willem R.

2003-01-01

For diagnosing radiation optic neuropathy (RON) ophthalmological and imaging data were evaluated from 63 acromegalic patients, irradiated between 1967 and 1998. Two patients developed RON: one patient in one optic nerve 10 years and another patient in both optic nerves 5 months after radiation therapy. RON is a rare complication after external beam radiation therapy for acromegaly, which can occur after a considerable latency period

An Extended Surface Loop on Toxoplasma gondii Apical Membrane Antigen 1 (AMA1 Governs Ligand Binding Selectivity.

Directory of Open Access Journals (Sweden)

Michelle L Parker

Full Text Available Apicomplexan parasites are the causative agents of globally prevalent diseases including malaria and toxoplasmosis. These obligate intracellular pathogens have evolved a sophisticated host cell invasion strategy that relies on a parasite-host cell junction anchored by interactions between apical membrane antigens (AMAs on the parasite surface and rhoptry neck 2 (RON2 proteins discharged from the parasite and embedded in the host cell membrane. Key to formation of the AMA1-RON2 complex is displacement of an extended surface loop on AMA1 called the DII loop. While conformational flexibility of the DII loop is required to expose the mature RON2 binding groove, a definitive role of this substructure has not been elucidated. To establish a role of the DII loop in Toxoplasma gondii AMA1, we engineered a form of the protein where the mobile portion of the loop was replaced with a short Gly-Ser linker (TgAMA1ΔDIIloop. Isothermal titration calorimetry measurements with a panel of RON2 peptides revealed an influential role for the DII loop in governing selectivity. Most notably, an Eimeria tenella RON2 (EtRON2 peptide that showed only weak binding to TgAMA1 bound with high affinity to TgAMA1ΔDIIloop. To define the molecular basis for the differential binding, we determined the crystal structure of TgAMA1ΔDIIloop in complex with the EtRON2 peptide. When analyzed in the context of existing AMA1-RON2 structures, spatially distinct anchor points in the AMA1 groove were identified that, when engaged, appear to provide the necessary traction to outcompete the DII loop. Collectively, these data support a model where the AMA1 DII loop serves as a structural gatekeeper to selectively filter out ligands otherwise capable of binding with high affinity in the AMA1 apical groove. These data also highlight the importance of considering the functional implications of the DII loop in the ongoing development of therapeutic intervention strategies targeting the AMA1-RON

An Automated Energy Detection Algorithm Based on Morphological Filter Processing with a Modified Watershed Transform

Science.gov (United States)

2018-01-01

ARL-TR-8270 ● JAN 2018 US Army Research Laboratory An Automated Energy Detection Algorithm Based on Morphological Filter...Automated Energy Detection Algorithm Based on Morphological Filter Processing with a Modified Watershed Transform by Kwok F Tom Sensors and Electron...1 October 2016–30 September 2017 4. TITLE AND SUBTITLE An Automated Energy Detection Algorithm Based on Morphological Filter Processing with a

A Combination Tissue Engineering Strategy for Schwann Cell-Induced Spinal Cord Repair

Science.gov (United States)

2015-10-01

manifests itself in the denser bone in tennis players ’ racket-holding arms or bone loss in astronauts. After the discovery of piezoresponse in dry...57 (2001) 477–484. [51] H.T. Nguyen, C. Wei, J.K. Chow, L. Nguy, H.K. Nguyen, C.E. Schmidt, Electric field stimulation through a substrate influences ...deformation in dry conditions. The range of electrical output and electric fields are shown in Table 1. The results show that at 1 Hz, 10% deformation

Command History. 1967. Volume 1. Sanitized

Science.gov (United States)

1967-01-01

the Politburo of the Lao Dong Party. This top political control center included Le Duan, General Vo Nguyen Glap, Truong Chinh , Le Duc Tho, and until...the support area Naval Support Activity (NSA) Da Nang’s vital intra- coastal trans -shipment route from the deep water port at Da Nang northward to...under the energetic guidance of MG Nguyen Duc Thang, reviewed PAGE 6 OF 1340 PAGES I% the entire process of RD and set to the task of revitalizing the

Brand Launching and Sustainingin a developing country : The case study of Honda on Vietnam Motorcycle Market

OpenAIRE

Nguyen, Thi Bich Ngoc; Nguyen, Thi Xuan Thu

2009-01-01

  Abstract Date May 29th, 2009 Course Master Thesis EFO705, International Marketing Tutor Daniel Tolstoy Authors Thi Bich Ngoc Nguyen Thi Xuan Thu Nguyen Title Brand Launching and Sustaining in a Developing CountryPurpose The project is to investigate the Brand Launching and Sustaining in a The Case Study of Honda on Vietnam Motorcycle Market developing country through the study on how Honda has successfully launched and sustained its Brand on the Motorcycle Market of Vietnam. Problems Hond...

Economic and environmental benefits of higher-octane gasoline.

Science.gov (United States)

Speth, Raymond L; Chow, Eric W; Malina, Robert; Barrett, Steven R H; Heywood, John B; Green, William H

2014-06-17

We quantify the economic and environmental benefits of designing U.S. light-duty vehicles (LDVs) to attain higher fuel economy by utilizing higher octane (98 RON) gasoline. We use engine simulations, a review of experimental data, and drive cycle simulations to estimate the reduction in fuel consumption associated with using higher-RON gasoline in individual vehicles. Lifecycle CO2 emissions and economic impacts for the U.S. LDV fleet are estimated based on a linear-programming refinery model, a historically calibrated fleet model, and a well-to-wheels emissions analysis. We find that greater use of high-RON gasoline in appropriately tuned vehicles could reduce annual gasoline consumption in the U.S. by 3.0-4.4%. Accounting for the increase in refinery emissions from production of additional high-RON gasoline, net CO2 emissions are reduced by 19-35 Mt/y in 2040 (2.5-4.7% of total direct LDV CO2 emissions). For the strategies studied, the annual direct economic benefit is estimated to be $0.4-6.4 billion in 2040, and the annual net societal benefit including the social cost of carbon is estimated to be $1.7-8.8 billion in 2040. Adoption of a RON standard in the U.S. in place of the current antiknock index (AKI) may enable refineries to produce larger quantities of high-RON gasoline.

The impact of Michigan's Dr Ron Davis smoke-free air law on levels of cotinine, tobacco-specific lung carcinogen and severity of self-reported respiratory symptoms among non-smoking bar employees.

Science.gov (United States)

Wilson, Teri; Shamo, Farid; Boynton, Katherine; Kiley, Janet

2012-11-01

To determine the impact on bar employee's health and exposure to secondhand smoke (SHS) before and after the implementation of Michigan's Dr Ron Davis smoke-free air law that went into effect on 1 May 2010, prohibiting smoking in places of work, including bars. This study used a pre/postintervention experimental design. The setting was bars in 12 Michigan counties. Subjects were bar employees, recruited through flyers and individual discussions with local health department staff. Participants completed a screening questionnaire to determine eligibility. A total of 40 eligible employees completed a demographic survey, provided urine samples for analysis of cotinine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and completed questionnaires on respiratory and general health status 6 weeks before and 6-10 weeks after the law went into effect. The main outcome measures were urine samples for total cotinine and total NNAL and data from a self-administered respiratory and general health status questionnaire collected during the pre-law and post-law study periods. There was a significant decrease in the mean cotinine levels from 35.9 ng/ml to a non-quantifiable value (plevel from 0.086 pmol/ml to 0.034 pmol/ml (plaw. There was also a significant improvement in all six self-reported respiratory symptoms (plaw is protecting bar employee health.

Predicting octane number using nuclear magnetic resonance spectroscopy and artificial neural networks

KAUST Repository

Abdul Jameel, Abdul Gani; Oudenhoven, Vincent Van; Emwas, Abdul-Hamid M.; Sarathy, Mani

2018-01-01

Machine learning algorithms are attracting significant interest for predicting complex chemical phenomenon. In this work, a model to predict research octane number (RON) and motor octane number (MON) of pure hydrocarbons, hydrocarbon-ethanol blends and gasoline-ethanol blends has been developed using artificial neural networks (ANN) and molecular parameters from 1H nuclear Magnetic Resonance (NMR) spectroscopy. RON and MON of 128 pure hydrocarbons, 123 hydrocarbon-ethanol blends of known composition and 30 FACE (fuels for advanced combustion engines) gasoline-ethanol blends were utilized as a dataset to develop the ANN model. The effect of weight % of seven functional groups including paraffinic CH3 groups, paraffinic CH2 groups, paraffinic CH groups, olefinic -CH=CH2 groups, naphthenic CH-CH2 groups, aromatic C-CH groups and ethanolic OH groups on RON and MON was studied. The effect of branching (i.e., methyl substitution), denoted by a parameter termed as branching index (BI), and molecular weight (MW) were included as inputs along with the seven functional groups to predict RON and MON. The topology of the developed ANN models for RON (9-540-314-1) and MON (9-340-603-1) have two hidden layers and a large number of nodes, and was validated against experimentally measured RON and MON of pure hydrocarbons, hydrocarbon-ethanol and gasoline-ethanol blends; a good correlation (R2=0.99) between the predicted and the experimental data was obtained. The average error of prediction for both RON and MON was found to be 1.2 which is close to the range of experimental uncertainty. This shows that the functional groups in a molecule or fuel can be used to predict its ON, and the complex relationship between them can be captured by tools like ANN.

Predicting octane number using nuclear magnetic resonance spectroscopy and artificial neural networks

KAUST Repository

Abdul Jameel, Abdul Gani

2018-04-17

Machine learning algorithms are attracting significant interest for predicting complex chemical phenomenon. In this work, a model to predict research octane number (RON) and motor octane number (MON) of pure hydrocarbons, hydrocarbon-ethanol blends and gasoline-ethanol blends has been developed using artificial neural networks (ANN) and molecular parameters from 1H nuclear Magnetic Resonance (NMR) spectroscopy. RON and MON of 128 pure hydrocarbons, 123 hydrocarbon-ethanol blends of known composition and 30 FACE (fuels for advanced combustion engines) gasoline-ethanol blends were utilized as a dataset to develop the ANN model. The effect of weight % of seven functional groups including paraffinic CH3 groups, paraffinic CH2 groups, paraffinic CH groups, olefinic -CH=CH2 groups, naphthenic CH-CH2 groups, aromatic C-CH groups and ethanolic OH groups on RON and MON was studied. The effect of branching (i.e., methyl substitution), denoted by a parameter termed as branching index (BI), and molecular weight (MW) were included as inputs along with the seven functional groups to predict RON and MON. The topology of the developed ANN models for RON (9-540-314-1) and MON (9-340-603-1) have two hidden layers and a large number of nodes, and was validated against experimentally measured RON and MON of pure hydrocarbons, hydrocarbon-ethanol and gasoline-ethanol blends; a good correlation (R2=0.99) between the predicted and the experimental data was obtained. The average error of prediction for both RON and MON was found to be 1.2 which is close to the range of experimental uncertainty. This shows that the functional groups in a molecule or fuel can be used to predict its ON, and the complex relationship between them can be captured by tools like ANN.

Resimulation of noise: a precision estimator for least square error curve-fitting tested for axial strain time constant imaging

Science.gov (United States)

Nair, S. P.; Righetti, R.

2015-05-01

Recent elastography techniques focus on imaging information on properties of materials which can be modeled as viscoelastic or poroelastic. These techniques often require the fitting of temporal strain data, acquired from either a creep or stress-relaxation experiment to a mathematical model using least square error (LSE) parameter estimation. It is known that the strain versus time relationships for tissues undergoing creep compression have a non-linear relationship. In non-linear cases, devising a measure of estimate reliability can be challenging. In this article, we have developed and tested a method to provide non linear LSE parameter estimate reliability: which we called Resimulation of Noise (RoN). RoN provides a measure of reliability by estimating the spread of parameter estimates from a single experiment realization. We have tested RoN specifically for the case of axial strain time constant parameter estimation in poroelastic media. Our tests show that the RoN estimated precision has a linear relationship to the actual precision of the LSE estimator. We have also compared results from the RoN derived measure of reliability against a commonly used reliability measure: the correlation coefficient (CorrCoeff). Our results show that CorrCoeff is a poor measure of estimate reliability for non-linear LSE parameter estimation. While the RoN is specifically tested only for axial strain time constant imaging, a general algorithm is provided for use in all LSE parameter estimation.

An experimental study of the effect of octane number higher than engine requirement on the engine performance and emissions

Energy Technology Data Exchange (ETDEWEB)

Sayin, Cenk; Kilicaslan, Ibrahim; Canakci, Mustafa; Ozsezen, Necati [Kocaeli Univ., Dept. of Mechanical Education, Izmit (Turkey)

2005-06-01

In this study, the effect of using higher-octane gasoline than that of engine requirement on the performance and exhaust emissions was experimentally studied. The test engine chosen has a fuel system with carburettor because 60% of the vehicles in Turkey are equipped with the carburettor. The engine, which required 91-RON (Research Octane Number) gasoline, was tested using 95-RON and 91-RON. Results show that using octane ratings higher than the requirement of an engine not only decreases engine performance but also increases exhaust emissions. (Author)

Hi-Plex for Simple, Accurate, and Cost-Effective Amplicon-based Targeted DNA Sequencing.

Science.gov (United States)

Pope, Bernard J; Hammet, Fleur; Nguyen-Dumont, Tu; Park, Daniel J

2018-01-01

Hi-Plex is a suite of methods to enable simple, accurate, and cost-effective highly multiplex PCR-based targeted sequencing (Nguyen-Dumont et al., Biotechniques 58:33-36, 2015). At its core is the principle of using gene-specific primers (GSPs) to "seed" (or target) the reaction and universal primers to "drive" the majority of the reaction. In this manner, effects on amplification efficiencies across the target amplicons can, to a large extent, be restricted to early seeding cycles. Product sizes are defined within a relatively narrow range to enable high-specificity size selection, replication uniformity across target sites (including in the context of fragmented input DNA such as that derived from fixed tumor specimens (Nguyen-Dumont et al., Biotechniques 55:69-74, 2013; Nguyen-Dumont et al., Anal Biochem 470:48-51, 2015), and application of high-specificity genetic variant calling algorithms (Pope et al., Source Code Biol Med 9:3, 2014; Park et al., BMC Bioinformatics 17:165, 2016). Hi-Plex offers a streamlined workflow that is suitable for testing large numbers of specimens without the need for automation.

Advanced Computing for 21st Century Accelerator Science and Technology

International Nuclear Information System (INIS)

Dragt, Alex J.

2004-01-01

Dr. Dragt of the University of Maryland is one of the Institutional Principal Investigators for the SciDAC Accelerator Modeling Project Advanced Computing for 21st Century Accelerator Science and Technology whose principal investigators are Dr. Kwok Ko (Stanford Linear Accelerator Center) and Dr. Robert Ryne (Lawrence Berkeley National Laboratory). This report covers the activities of Dr. Dragt while at Berkeley during spring 2002 and at Maryland during fall 2003

Obituary: Ronald Cecil Stone, 1946-2005

Science.gov (United States)

Monet, Alice Kay Babcock

2006-12-01

Ronald C. Stone, an astronomer at the US Naval Observatory Flagstaff Station, passed away on 10 September 2005 in Downer's Grove, IL, following a valiant struggle with cancer. He was fifty-nine years old. Ron was born on 9 June 1946 in Seattle, Washington, to Helen (Vocelka) and Cecil Stone. His father was a World War II veteran who attended college on the GI Bill and became a mechanical engineer. He and his wife raised three sons: Dwight, Ronald, and Gavin. They lived in a number of locations across the U.S. before settling at last in Downer's Grove when Ron was in the fourth grade. Ron's interest in astronomy began when he was given a toy planetarium projector while still in grade school, and later a small telescope. In high school, he also built his own telescope, grinding the 6-inch mirror by hand. He completed grade school and high school in Downer's Grove and did his undergraduate studies at the University of Illinois at Urbana-Champaign, majoring in astronomy and physics and graduating cum laude in 1968. The following year, he was drafted into the U.S. Army and served for two years, including a stint in Vietnam. Although his primary assignment was auditing, he was also involved in the defense of the Long Binh base in Vietnam. He was honorably discharged from the service in 1971 and enrolled that fall at the University of Chicago. While a graduate student working with Bill van Altena, Ron developed his life long interest in the field of astrometry. Van Altena recalls him as "a quiet and cheerful student who wanted to learn, and [who] worked hard to understand the intricacies of astrometry... deriving the most precise proper motions from the 40-inch [Yerkes] refractor plates." Working at Yerkes Observatory in Williams Bay, Wisconsin, he completed a thesis entitled, "Mean Secular Parallax at Low Galactic Latitude." While living in Wisconsin, Ron also became engaged to Ellen Mickel, and the two were married at his parents' home in Downer's Grove. After earning

ECUT: Energy Conversion and Utilization Technologies program. Industry, university and research interest in the US Department of Energy ECUT biocatalysis research activity

Science.gov (United States)

Wilcox, R. E.

1983-01-01

The results of a Research Opportunity Notice (RON) disseminated by the Jet Propulsion Laboratory for the U.S. Department of Energy Conversion and Utilization Technologies (ECUT) Program's Biocatalysis Research Activity are presented. The RON was issued in late April of 1983 and solicited expressions of interest from petrochemical and chemical companies, bioengineering firms, biochemical engineering consultants, private research laboratories, and universities for participating in a federal research program to investigate potential applications of biotechnology in producing chemicals. The RON results indicate that broad interest exists within the nation's industry, universities, and research institutes for the Activity and its planned research and development program.

Mitchell Receives 2013 Ronald Greeley Early Career Award in Planetary Science: Response

Science.gov (United States)

Mitchell, Jonathan L.

2014-07-01

I am honored to receive this award in memory of Ron Greeley. Although I did not have the opportunity to know him, I had the pleasure of getting to know his wife, Cynthia, at a luncheon prior to the special awards session at the AGU Fall Meeting. Cynthia is an intelligent and elegant southern woman with a confident gaze. She spoke fondly of Ron and of her sincere respect for his work ethic and dedication to planetary science. What most impressed me, though, was the respect Ron showed to her and the kids by always "giving them the evenings"; no matter how busy things got, Ron always kept his evenings open for Cynthia. This clearly meant the world to her. As a family man, I can only hope that my wife and kids will speak so kindly of me many years from now. I would like to dedicate this award to them in gratitude for their seemingly unconditional love and support.

3D-printed patient-specific applications in orthopedics

OpenAIRE

Wong KC

2016-01-01

Kwok Chuen Wong Department of Orthopedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong Abstract: With advances in both medical imaging and computer programming, two-dimensional axial images can be processed into other reformatted views (sagittal and coronal) and three-dimensional (3D) virtual models that represent a patients’ own anatomy. This processed digital information can be analyzed in detail by orthopedic surgeons to perform p...

Soon at a theater near you...

CERN Multimedia

Connie Potter

While at CERN recently gathering images and input for his new movie based on Dan Brown's best-seller "Angels and Demons", director Ron Howard and his technical designer managed to fit in a visit to the ATLAS cavern accompanied by Rolf "Antimatter" Landua from CERN and members of the CERN Press Office. Both were very impressed with the ATLAS installations, with Ron Howard's parting words being...."Tom's going to love this"! So, all you cavern-dwellers... keep your eyes open... for 'Tom'! Ron Howard, director of the "Da Vinci Code" movie, checked out the scene in the ATLAS cavern, preparing for his new project, "Angels and Demons".

MÉTODOS DE ESTIMATIVA DE PESO E ALTURA NA AVALIAÇÃO DE DESNUTRIÇÃO DE PACIENTES COM CÂNCER

Directory of Open Access Journals (Sweden)

Juliana Alvares Duarte Bonini CAMPOS

2012-12-01

Full Text Available Calcular as medidas reais e estimadas de peso e altura em pacientes oncológicos, avaliar a correlação e a concordância destas medidas e identificar os pacientes desnutridos. Participaram 62 pacientes oncológicos, atendidos no Hospital Amaral Carvalho (Jaú-SP. Para classificação do estado nutricional, utilizou-se a Avaliação Subjetiva Global – Produzida Pelo Paciente, o Índice de Massa Corporal e as relações com peso habitual. Para o peso estimado, utilizou-se o algoritmo proposto por Chumlea et al.8 e para altura estimada, as equações proposta por Chumlea et al.7 e por Kwok & Whitelaw.24 Calculou-se o Coeficiente de Correlação de Pearson e Coeficiente de Correlação Intraclasse e realizou-se regressão linear simples. Para comparar a presença de desnutrição detectada pelos diferentes métodos, utilizou-se o teste Q de Cochran. Observou-se correlação forte e significativa entre o peso real e o estimado (r=0,95, IC95%=0,92-0,97, p<0,001 e concordância excelente (ρ=0,95. Para as medidas de altura, observouse correlação significativa entre a medida real e estimada pelo método Chumlea et al.7 (r=0,78, IC95%=0,66-0,86, p<0,001 e Kwok & Whitelaw24 (r=0,85, IC95%: 0,75-0,90, p<0,001. A concordância foi “Boa” (ρ=0,72 e “Moderada” (ρ=0,67 entre a altura real e estimada por Chumlea et al.7 e Kwok & Whitelaw,24 respectivamente. Houve forte correlação entre as medidas reais e estimadas de peso e altura. A reprodutibilidade da equação proposta por Chumlea et al.7 para o cálculo da altura foi melhor. Quanto ao estado nutricional, os pacientes classificados como desnutridos foi maior ao se utilizar a Avaliação Subjetiva Global – Produzida Pelo Paciente e as relações com peso habitual.

Magnaat maailma katusel / Ron Gluckman

Index Scriptorium Estoniae

Gluckman, Ron

2013-01-01

Buthani tõenäoliselt rikkaima mehe Dasho Topgyal Dorji äriimpeeriumist Tashi Group, mille tegevusaladeks on nt hotellindus, pangandus, ehitus, toiduained, mobiilside, lennundus. Dorji on pühendunud riigisisesele koguõnnele, mis ei välista ka materiaalsete olude parandamist

Obituary: Ronald Eugene Pitts, 1949-2008

Science.gov (United States)

MacConnell, D. Jack

2009-01-01

Ronald Pitts, systems engineer in the Commanding Branch of the Space Telescope Science Institute and long-time Computer Sciences Corporation employee, died suddenly of a stroke on 4 May 2008 at his home in Laurel, Maryland. He was a dedicated scientist-engineer, husband, father, volunteer, and cherished friend to many. Ron was born on 19 January 1949 in Tucson, Arizona, and was raised, along with his sister Suzanne, on his parents' turkey farm outside Tucson. He picked up practical knowledge from his father, Vernon, and became a competent amateur electrician and plumber, skills he kept honed and used throughout his life. His mother, Ruth (Stephens), was a nurse and taught him compassion and patience and encouraged his inquisitive mind. Ron attended public schools and enrolled at the University of Arizona, graduating with a B. S. in Astronomy in 1971. Being from a family of modest means, he put himself through school working summers and part-time at a large copper mine south of town. Ron enrolled in the graduate astronomy program at the Ohio State University [OSU] in the fall of 1971 where he was a first-year fellowship student. During his second and third years, he was the Perkins Assistant, taking spectra for the very exacting but appreciative Philip Keenan who once remarked to another faculty member that Ron was the best observer he ever had. Later, in 1980, Ron was co-author with Keenan on "Revised MK Spectral Types for G, K, and M stars" and again in 1985 in a study of supergiants in open clusters. He met his future wife, Patricia Moore, also a graduate student in the department, and they were wed in 1973. Ron was also partially supported during his early OSU years by an NSF grant to Robert Wing, writing parts of Wing's photometric reduction code and observing on the program at Kitt Peak and Flagstaff in the summer of 1974. Wing remembers him as being very competent and pleasant to work with. Ron's thesis topic was "Oscillator Strengths for Neutral Iron and

77 FR 25660 - State of Nevada; Regional Haze State and Federal Implementation Plans; BART Determination for...

Science.gov (United States)

2012-05-01

...), EPA announced a public hearing in Ron Dalley Theater at the Moapa Valley Empowerment High School on... 18, 2012, EPA announced a public hearing in Ron Dalley Theater at the Moapa Valley Empowerment High School on 2400 St. Joseph Street in Overton, Nevada from 6:30 p.m. to 8:30 p.m. on May 3, 2012, with an...

First Person Past: American Autobiographies, Volume 2

DEFF Research Database (Denmark)

American literature, biography, Tunis Campbell, Black Elk, Andrew Carnegie, Booker T. Washington, Mary Antin, Mary Jones, Frederic Howe, Anna Howard Shaw, Woody Guthrie, Monica Sone, Anne Moody, Ron Kovic......American literature, biography, Tunis Campbell, Black Elk, Andrew Carnegie, Booker T. Washington, Mary Antin, Mary Jones, Frederic Howe, Anna Howard Shaw, Woody Guthrie, Monica Sone, Anne Moody, Ron Kovic...

Role of ionization fronts in the colliding wind model of planetary nebulae

International Nuclear Information System (INIS)

Giuliani, J.L. Jr.

1981-01-01

A similarity transformation is used to study the expansion of a planetary nebula which is driven by a fast stellar wind as well as an expanding H II region. The undisturbed gas is taken to be the remnant of a slow, red giant wind. The present analysis improves upon Kwok, Purton, and FitzGerald's colliding wind model for the formation of planetary nebulae since it includes the dynamical influence of ionization fronts, and calculates the variation of velocity and density within the flow

EU adoption of the IFRS 8 standard on operating segments

OpenAIRE

Nicolas Véron

2007-01-01

In this paper, presented to the Economic and Monetary Affairs Committee of the European Parliament, Nicolas Véron discusses whether the EU should adopt the controversial IFRS 8 standard, a convergence project on how companies should report the performance of their individual business segments. Vérons recommendation is for the European Union not to adopt the current version of IFRS 8.

Rewarding Resilience

Science.gov (United States)

Ruffins, Paul

2010-01-01

This article discusses how the Ron Brown Scholars program has helped many students of color persist and fit in at elite institutions. Established in 1996 to honor the memory of Ron Brown, the first Black Secretary of Commerce who died in a 1996 military plane crash in Croatia while on a trade mission to Europe, the program each year awards $40,000…

Suppression of human breast tumors in NOD/SCID mice by CD44 shRNA gene therapy combined with doxorubicin treatment

Directory of Open Access Journals (Sweden)

Pham PV

2012-05-01

Full Text Available Phuc Van Pham1, Ngoc Bich Vu1, Thuy Thanh Duong1, Tam Thanh Nguyen1, Nhung Hai Truong1, Nhan Lu Chinh Phan1, Tue Gia Vuong1, Viet Quoc Pham1, Hoang Minh Nguyen1, Kha The Nguyen1, Nhung Thi Nguyen1, Khue Gia Nguyen1, Lam Tan Khat1, Dong Van Le2, Kiet Dinh Truong1, Ngoc Kim Phan11Laboratory of Stem Cell Research and Application, University of Science, Vietnam National University, HCM City, 2Military Medical University, Ha Noi, VietnamBackground: Breast cancer stem cells with a CD44+CD24- phenotype are the origin of breast tumors. Strong CD44 expression in this population indicates its important role in maintaining the stem cell phenotype. Previous studies show that CD44 down-regulation causes CD44+CD24- breast cancer stem cells to differentiate into non-stem cells that are sensitive to antitumor drugs and lose many characteristics of the original cells. In this study, we determined tumor suppression in non-obese severe combined immunodeficiency mice using CD44 shRNA therapy combined with doxorubicin treatment.Methods: Tumor-bearing non-obese severe combined immunodeficiency mice were established by injection of CD44+CD24- cells. To track CD44+CD24- cells, green fluorescence protein was stably transduced using a lentiviral vector prior to injection into mice. The amount of CD44 shRNA lentiviral vector used for transduction was based on CD44 down-regulation by in vitro CD44 shRNA transduction. Mice were treated with direct injection of CD44 shRNA lentiviral vector into tumors followed by doxorubicin administration after 48 hours. The effect was evaluated by changes in the size and weight of tumors compared with that of the control.Results: The combination of CD44 down-regulation and doxorubicin strongly suppressed tumor growth with significant differences in tumor sizes and weights compared with that of CD44 down-regulation or doxorubicin treatment alone. In the combination of CD44 down-regulation and doxorubicin group, the tumor weight was

Antivascular Endothelial Growth Factor Bevacizumab for Radiation Optic Neuropathy: Secondary to Plaque Radiotherapy

International Nuclear Information System (INIS)

Finger, Paul T.; Chin, Kimberly J.

2012-01-01

Purpose: To evaluate the intravitreal antivascular endothelial growth factor, bevacizumab, for treatment of radiation optic neuropathy (RON). Methods and Materials: A prospective interventional clinical case series was performed of 14 patients with RON related to plaque radiotherapy for choroidal melanoma. The RON was characterized by optic disc edema, hemorrhages, microangiopathy, and neovascularization. The entry criteria included a subjective or objective loss of vision, coupled with findings of RON. The study subjects received a minimum of two initial injections of intravitreal bevacizumab (1.25 mg in 0.05 mL) every 6–8 weeks. The primary objectives included safety and tolerability. The secondary objectives included the efficacy as measured using the Early Treatment Diabetic Retinopathy Study chart for visual acuity, fundus photography, angiography, and optical coherence tomography/scanning laser ophthalmoscopy. Results: Reductions in optic disc hemorrhage and edema were noted in all patients. The visual acuity was stable or improved in 9 (64%) of the 14 patients. Of the 5 patients who had lost vision, 2 had relatively large posterior tumors, 1 had had the vision decrease because of intraocular hemorrhage, and 1 had developed optic atrophy. The fifth patient who lost vision was noncompliant. No treatment-related ocular or systemic side effects were observed. Conclusions: Intravitreal antivascular endothelial growth factor bevacizumab was tolerated and generally associated with improved vision, reduced papillary hemorrhage, and resolution of optic disc edema. Persistent optic disc neovascularization and fluorescein angiographic leakage were invariably noted. The results of the present study support additional evaluation of antivascular endothelial growth factor medications as treatment of RON.

A methodology to relate octane numbers of binary and ternary n-heptane, iso-octane and toluene mixtures with simulated ignition delay times

KAUST Repository

Badra, Jihad A.

2015-08-11

Predicting octane numbers (ON) of gasoline surrogate mixtures is of significant importance to the optimization and development of internal combustion (IC) engines. Most ON predictive tools utilize blending rules wherein measured octane numbers are fitted using linear or non-linear mixture fractions on a volumetric or molar basis. In this work, the octane numbers of various binary and ternary n-heptane/iso-octane/toluene blends, referred to as toluene primary reference fuel (TPRF) mixtures, are correlated with a fundamental chemical kinetic parameter, specifically, homogeneous gas-phase fuel/air ignition delay time. Ignition delay times for stoichiometric fuel/air mixtures are calculated at various constant volume conditions (835 K and 20 atm, 825 K and 25 atm, 850 K and 50 atm (research octane number RON-like) and 980 K and 45 atm (motor octane number MON-like)), and for variable volume profiles calculated from cooperative fuel research (CFR) engine pressure and temperature simulations. Compression ratio (or ON) dependent variable volume profile ignition delay times are investigated as well. The constant volume RON-like ignition delay times correlation with RON was the best amongst the other studied conditions. The variable volume ignition delay times condition correlates better with MON than the ignition delay times at the other tested conditions. The best correlation is achieved when using compression ratio dependent variable volume profiles to calculate the ignition delay times. Most of the predicted research octane numbers (RON) have uncertainties that are lower than the repeatability and reproducibility limits of the measurements. Motor octane number (MON) correlation generally has larger uncertainties than that of RON.

Decadal changes in summertime reactive oxidized nitrogen and surface ozone over the Southeast United States

Science.gov (United States)

Li, Jingyi; Mao, Jingqiu; Fiore, Arlene M.; Cohen, Ronald C.; Crounse, John D.; Teng, Alex P.; Wennberg, Paul O.; Lee, Ben H.; Lopez-Hilfiker, Felipe D.; Thornton, Joel A.; Peischl, Jeff; Pollack, Ilana B.; Ryerson, Thomas B.; Veres, Patrick; Roberts, James M.; Neuman, J. Andrew; Nowak, John B.; Wolfe, Glenn M.; Hanisco, Thomas F.; Fried, Alan; Singh, Hanwant B.; Dibb, Jack; Paulot, Fabien; Horowitz, Larry W.

2018-02-01

Widespread efforts to abate ozone (O3) smog have significantly reduced emissions of nitrogen oxides (NOx) over the past 2 decades in the Southeast US, a place heavily influenced by both anthropogenic and biogenic emissions. How reactive nitrogen speciation responds to the reduction in NOx emissions in this region remains to be elucidated. Here we exploit aircraft measurements from ICARTT (July-August 2004), SENEX (June-July 2013), and SEAC4RS (August-September 2013) and long-term ground measurement networks alongside a global chemistry-climate model to examine decadal changes in summertime reactive oxidized nitrogen (RON) and ozone over the Southeast US. We show that our model can reproduce the mean vertical profiles of major RON species and the total (NOy) in both 2004 and 2013. Among the major RON species, nitric acid (HNO3) is dominant (˜ 42-45 %), followed by NOx (31 %), total peroxy nitrates (ΣPNs; 14 %), and total alkyl nitrates (ΣANs; 9-12 %) on a regional scale. We find that most RON species, including NOx, ΣPNs, and HNO3, decline proportionally with decreasing NOx emissions in this region, leading to a similar decline in NOy. This linear response might be in part due to the nearly constant summertime supply of biogenic VOC emissions in this region. Our model captures the observed relative change in RON and surface ozone from 2004 to 2013. Model sensitivity tests indicate that further reductions of NOx emissions will lead to a continued decline in surface ozone and less frequent high-ozone events.

Antivascular Endothelial Growth Factor Bevacizumab for Radiation Optic Neuropathy: Secondary to Plaque Radiotherapy

Energy Technology Data Exchange (ETDEWEB)

Finger, Paul T., E-mail: pfinger@eyecancer.com [New York Eye Cancer Center, New York, NY (United States); Chin, Kimberly J. [New York Eye Cancer Center, New York, NY (United States)

2012-02-01

Purpose: To evaluate the intravitreal antivascular endothelial growth factor, bevacizumab, for treatment of radiation optic neuropathy (RON). Methods and Materials: A prospective interventional clinical case series was performed of 14 patients with RON related to plaque radiotherapy for choroidal melanoma. The RON was characterized by optic disc edema, hemorrhages, microangiopathy, and neovascularization. The entry criteria included a subjective or objective loss of vision, coupled with findings of RON. The study subjects received a minimum of two initial injections of intravitreal bevacizumab (1.25 mg in 0.05 mL) every 6-8 weeks. The primary objectives included safety and tolerability. The secondary objectives included the efficacy as measured using the Early Treatment Diabetic Retinopathy Study chart for visual acuity, fundus photography, angiography, and optical coherence tomography/scanning laser ophthalmoscopy. Results: Reductions in optic disc hemorrhage and edema were noted in all patients. The visual acuity was stable or improved in 9 (64%) of the 14 patients. Of the 5 patients who had lost vision, 2 had relatively large posterior tumors, 1 had had the vision decrease because of intraocular hemorrhage, and 1 had developed optic atrophy. The fifth patient who lost vision was noncompliant. No treatment-related ocular or systemic side effects were observed. Conclusions: Intravitreal antivascular endothelial growth factor bevacizumab was tolerated and generally associated with improved vision, reduced papillary hemorrhage, and resolution of optic disc edema. Persistent optic disc neovascularization and fluorescein angiographic leakage were invariably noted. The results of the present study support additional evaluation of antivascular endothelial growth factor medications as treatment of RON.

Radiation optic neuropathy

International Nuclear Information System (INIS)

Kline, L.B.; Kim, J.Y.; Ceballos, R.

1985-01-01

Following surgery for pituitary adenoma, radiation therapy is an accepted treatment in reducing tumor recurrence. However, a potential therapeutic complication is delayed radionecrosis of perisellar neural structures, including the optic nerves and chiasm. This particular cause of visual loss, radiation optic neuropathy (RON), has not been emphasized in the ophthalmologic literature. Four cases of RON seen in the past five years are reported. Diagnostic criteria include: (1) acute visual loss (monocular or binocular), (2) visual field defects indicating optic nerve or chiasmal dysfunction, (3) absence of optic disc edema, (4) onset usually within three years of therapy (peak: 1-1 1/2 years), and (5) no computed tomographic evidence of visual pathway compression. Pathologic findings, differential diagnosis and therapy will be discussed in outlining the clinical profile of RON

Calcium in the Mechanism of Ammonia-Induced Astrocyte Swelling

Science.gov (United States)

Jayakumar, A.R.; Rao, K.V. Rama; Tong, X.Y; Norenberg, M.D.

2016-01-01

Brain edema, due largely to astrocyte swelling, is an important clinical problem in patients with acute liver failure. While mechanisms underlying astrocyte swelling in this condition are not fully understood, ammonia and associated oxidative/nitrosative stress (ONS) appear to be involved. Mechanisms responsible for the increase in reactive oxygen/nitrogen species (RONS) and their role in ammonia-induced astrocyte swelling, however, are poorly understood. Recent studies have demonstrated a transient increase in intracellular Ca2+ in cultured astrocytes exposed to ammonia. As Ca2+ is a known inducer of RONS, we investigated potential mechanisms by which Ca2+ may be responsible for the production of RONS and cell swelling in cultured astrocytes after treatment with ammonia. Exposure of cultured astrocytes to ammonia (5 mM) increased the formation of free radicals, including nitric oxide, and such increase was significantly diminished by treatment with the Ca2+ chelator BAPTA-AM. We then examined the activity of Ca2+-dependent enzymes that are known to generate RONS and found that ammonia significantly increased the activities of NADPH oxidase (NOX), constitutive nitric oxide synthase (cNOS) and phospholipase A2 (PLA2) and such increases in activity were significantly diminished by BAPTA. Pretreatment of cultures with 7-nitroindazole, apocyanin and quinacrine, respective inhibitors of cNOS, NOX and PLA2, all significantly diminished RONS production. Additionally, treatment of cultures with BAPTA or with inhibitors of cNOS, NOX and PLA2 reduced ammonia-induced astrocyte swelling. These studies suggest that the ammonia-induced rise in intracellular Ca2+ activates free radical producing enzymes that ultimately contribute to the mechanism of astrocyte swelling. PMID:19393035

Decadal changes in summertime reactive oxidized nitrogen and surface ozone over the Southeast United States

Directory of Open Access Journals (Sweden)

J. Li

2018-02-01

Full Text Available Widespread efforts to abate ozone (O3 smog have significantly reduced emissions of nitrogen oxides (NOx over the past 2 decades in the Southeast US, a place heavily influenced by both anthropogenic and biogenic emissions. How reactive nitrogen speciation responds to the reduction in NOx emissions in this region remains to be elucidated. Here we exploit aircraft measurements from ICARTT (July–August 2004, SENEX (June–July 2013, and SEAC4RS (August–September 2013 and long-term ground measurement networks alongside a global chemistry–climate model to examine decadal changes in summertime reactive oxidized nitrogen (RON and ozone over the Southeast US. We show that our model can reproduce the mean vertical profiles of major RON species and the total (NOy in both 2004 and 2013. Among the major RON species, nitric acid (HNO3 is dominant (∼ 42–45 %, followed by NOx (31 %, total peroxy nitrates (ΣPNs; 14 %, and total alkyl nitrates (ΣANs; 9–12 % on a regional scale. We find that most RON species, including NOx, ΣPNs, and HNO3, decline proportionally with decreasing NOx emissions in this region, leading to a similar decline in NOy. This linear response might be in part due to the nearly constant summertime supply of biogenic VOC emissions in this region. Our model captures the observed relative change in RON and surface ozone from 2004 to 2013. Model sensitivity tests indicate that further reductions of NOx emissions will lead to a continued decline in surface ozone and less frequent high-ozone events.

Estimating fuel octane numbers from homogeneous gas-phase ignition delay times

KAUST Repository

Naser, Nimal

2017-11-05

Fuel octane numbers are directly related to the autoignition properties of fuel/air mixtures in spark ignition (SI) engines. This work presents a methodology to estimate the research and the motor octane numbers (RON and MON) from homogeneous gas-phase ignition delay time (IDT) data calculated at various pressures and temperatures. The hypothesis under investigation is that at specific conditions of pressure and temperature (i.e., RON-like and MON-like conditions), fuels with IDT identical to that of a primary reference fuel (PRF) have the same octane rating. To test this hypothesis, IDTs with a detailed gasoline surrogate chemical kinetic model have been calculated at various temperatures and pressures. From this dataset, temperatures that best represent RON and MON have been correlated at a specified pressure. Correlations for pressures in the range of 10–50 bar were obtained. The proposed correlations were validated with toluene reference fuels (TRF), toluene primary reference fuels (TPRF), ethanol reference fuels (ERF), PRFs and TPRFs with ethanol, and multi-component gasoline surrogate mixtures. The predicted RON and MON showed satisfactory accuracy against measurements obtained by the standard ASTM methods and blending rules, demonstrating that the present methodology can be a viable tool for a first approximation. The correlations were also validated against an extensive set of experimental IDT data obtained from literature with a high degree of accuracy in RON/MON prediction. Conditions in homogeneous reactors such as shock tubes and rapid compression machines that are relevant to modern SI engines were also identified. Uncertainty analysis of the proposed correlations with linear error propagation theory is also presented.

Estimating fuel octane numbers from homogeneous gas-phase ignition delay times

KAUST Repository

Naser, Nimal; Sarathy, Mani; Chung, Suk-Ho

2017-01-01

Fuel octane numbers are directly related to the autoignition properties of fuel/air mixtures in spark ignition (SI) engines. This work presents a methodology to estimate the research and the motor octane numbers (RON and MON) from homogeneous gas-phase ignition delay time (IDT) data calculated at various pressures and temperatures. The hypothesis under investigation is that at specific conditions of pressure and temperature (i.e., RON-like and MON-like conditions), fuels with IDT identical to that of a primary reference fuel (PRF) have the same octane rating. To test this hypothesis, IDTs with a detailed gasoline surrogate chemical kinetic model have been calculated at various temperatures and pressures. From this dataset, temperatures that best represent RON and MON have been correlated at a specified pressure. Correlations for pressures in the range of 10–50 bar were obtained. The proposed correlations were validated with toluene reference fuels (TRF), toluene primary reference fuels (TPRF), ethanol reference fuels (ERF), PRFs and TPRFs with ethanol, and multi-component gasoline surrogate mixtures. The predicted RON and MON showed satisfactory accuracy against measurements obtained by the standard ASTM methods and blending rules, demonstrating that the present methodology can be a viable tool for a first approximation. The correlations were also validated against an extensive set of experimental IDT data obtained from literature with a high degree of accuracy in RON/MON prediction. Conditions in homogeneous reactors such as shock tubes and rapid compression machines that are relevant to modern SI engines were also identified. Uncertainty analysis of the proposed correlations with linear error propagation theory is also presented.

Radial optic neurotomy for ischaemic central vein occlusion

Science.gov (United States)

Martínez-Jardón, C S; Meza-de Regil, A; Dalma-Weiszhausz, J; Leizaola-Fernández, C; Morales-Cantón, V; Guerrero-Naranjo, J L; Quiroz-Mercado, H

2005-01-01

Background/aims: Ischaemic central retinal vein occlusion (CRVO) accounts for 20–50% of all CRVO. No treatment has been proved to be effective. The efficacy of radial optic neurotomy (RON) was evaluated in eyes with ischaemic CRVO. Methods: 10 patients with ischaemic CRVO underwent RON. After pars plana vitrectomy, a microvitreoretinal blade was used to incise the scleral ring, cribriform plate, and adjacent sclera at the nasal edge of the optic disc. Best corrected visual acuity (BCVA), intraocular pressure (IOP), fluorescein angiography (FA), multifocal electroretinography (mfERG), and optical coherence tomography (OCT) were measured preoperatively and at 1, 3, and 6 months postoperatively. Results: No visual improvement was noted in the eyes that underwent RON. FA and mfERG showed no increase in retinal perfusion or retinal function postoperatively. Mean macular central thickness changed from 841 (SD 170) μm preoperatively to 162 (SD 34) μm at the sixth postoperative month. One patient had retinal central artery perforation intraoperatively. One patient developed neovascular glaucoma. Conclusion: RON in ischaemic CRVO did not improve visual function (by mfERG) or visual acuity although macular thickness did improve. This technique may be associated with potential risks. Randomised studies are needed to corroborate these results. PMID:15834084

Comprehensive dynamic on-resistance assessments in GaN-on-Si MIS-HEMTs for power switching applications

Science.gov (United States)

Chou, Po-Chien; Hsieh, Ting-En; Cheng, Stone; del Alamo, Jesús A.; Chang, Edward Yi

2018-05-01

This study comprehensively analyzed the reliability of trapping and hot-electron effects responsible for the dynamic on-resistance (Ron) of GaN-based metal–insulator–semiconductor high electron mobility transistors. Specifically, this study performed the following analyses. First, we developed the on-the-fly Ron measurement to analyze the effects of traps during stress. With this technique, the faster one (with a pulse period of 20 ms) can characterize the degradation; the transient behavior could be monitored accurately by such short measurement pulse. Then, dynamic Ron transients were investigated under different bias conditions, including combined off state stress conditions, back-gating stress conditions, and semi-on stress conditions, in separate investigations of surface- and buffer-, and hot-electron-related trapping effects. Finally, the experiments showed that the Ron increase in semi-on state is significantly correlated with the high drain voltage and relatively high current levels (compared with the off-state current), involving the injection of greater amount of hot electrons from the channel into the AlGaN/insulator interface and the GaN buffer. These findings provide a path for device engineering to clarify the possible origins for electron traps and to accelerate the development of emerging GaN technologies.

Who would benefit from memory training? A pilot study examining the ceiling effect of concurrent cognitive stimulation

OpenAIRE

Kwok, Timothy CY; Chau, Wai Wang; Yuen, Kenneth SL; Wong, Anita YM; Li, Jessie CY; Shiu, Rebecca YY; Ho, Florence KY

2011-01-01

Timothy CY Kwok1,2, Wai Wang Chau1, Kenneth SL Yuen1,3, Anita YM Wong4, Jessie CY Li1, Rebecca YY Shiu4, Florence KY Ho11Jockey Club Centre for Positive Ageing, Hong Kong; 2Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong; 3Laboratory of Neuropsychology, Department of Psychology, University of Hong Kong, Pokfulam, Hong Kong; 4The Hong Kong Chinese Women's Club Madam Wong Chan Sook Ying Memorial Care and Attention Home for the Aged, Hong KongAbstr...

Crosstalk: The Journal of Defense Software Engineering. Volume 22, Number 2, February 2009

Science.gov (United States)

2009-02-01

possible system attacks. by Ron Greenfield and Dr. Charley Tichenor Enforcing Static Program Properties to Enable Safety-Critical Use of Java Software...Assurance by Ron Greenfield and Dr. Charley Tichenor, and Dr. Kelvin Nilsen’s Enforcing Static Program Properties in Safety-Critical Java Software Components...01&lang=en>. 5. Shakespeare, William. The Tempest. 6. Intel. “How Chips are Made.” 2008 <www.intel.com/ education /making chips/preparation.htm>. 7

International Conference on Advances in Information and Communication Technology

CERN Document Server

Nguyen, Thanh-Thuy; Vu, Duc-Thai; Phung, Trung-Nghia; Huynh, Van-Nam

2017-01-01

This book features papers presented at the International Conference on Advances in Information and Communication Technology (ICTA 2016), which was held in Thai Nguyen city, Vietnam, from December 1 to 13, 2016. The conference was jointly organized by Thai Nguyen University of Information and Communication Technology (ICTU), the Institute of Information Technology – Vietnam Academy of Science and Technology (IoIT), Feng Chia University, Taiwan (FCU), the Japan Advanced Institute of Science and Technology (JAIST) and the National Chung Cheng University, Taiwan (CCU) with the aim of bringing together researchers, academics, practitioners and students to not only share research results and practical applications but also to foster collaboration in information and communication technology research and education. The book includes the 66 best peer-reviewed papers, selected from the 150 submissions received.

DETERMINATION OF CAFFEINE CONTENTS OF COFFEE BRANDS IN THE VIETNAMESE MARKET

Directory of Open Access Journals (Sweden)

Stanislav Kráčmar

2012-02-01

Full Text Available In this study, the caffeine contents in five certain Vietnamese coffee (Dak Tin, Di Linh, Nam Nguyen, Origin and Vinacafe found in the Vietnamese market were determined using UV/vis spectrophotometry. The quantification of caffeine sample was calculated by standard addition method. Our results showed that the caffeine contents in coffee brewing were influenced by temperature of water used to brew, time of brewing, and independent on the volume of water, respectively. In general, higher concentrations of caffeine were found in all samples prepared at temperature 100°C for 5 minutes. The order of caffeine contents in coffee samples was Dak Tin, Di Linh, Nam Nguyen, Origin and Vinacafe, respectively. This study can contribute to a better knowledge of caffeine contents in Vietnamese coffee of Vietnamese consumers.

Short Communication

African Journals Online (AJOL)

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2014-03-21

Mar 21, 2014 ... Comparative Study on Antimicrobial Activity of Vitex negundo var. negundo and Vitex negundo ... (Nguyen-Pouplin et al., 2007), anthelmintic (Merekar et al., 2011), wound ..... Efficacy of garlic extract and mancozeb against ...

75 FR 62112 - Notice of Availability of a Broad Spectrum of Patents for Exclusive, Partially Exclusive, or Non...

Science.gov (United States)

2010-10-07

... Systems and methods for collecting particles from a large volume of gas into a small volume of liquid... semiconductor laser systems and methods. Nguyen 7,796,829 Method and system for forming an image with enhanced...

Auto-Ignition of Iso-Stoichiometric Blends of Gasoline-Ethanol-Methanol (GEM) in SI, HCCI and CI Combustion Modes

KAUST Repository

Waqas, Muhammad

2017-03-28

Gasoline-ethanol-methanol (GEM) blends, with constant stoichiometric air-to-fuel ratio (iso-stoichiometric blending rule) and equivalent to binary gasoline-ethanol blends (E2, E5, E10 and E15 in % vol.), were defined to investigate the effect of methanol and combined mixtures of ethanol and methanol when blended with three FACE (Fuels for Advanced Combustion Engines) Gasolines, I, J and A corresponding to RON 70.2, 73.8 and 83.9, respectively, and their corresponding Primary Reference Fuels (PRFs). A Cooperative Fuel Research (CFR) engine was used under Spark Ignition and Homogeneous Charge Compression Ignited modes. An ignition quality tester was utilized in the Compression Ignition mode. One of the promising properties of GEM blends, which are derived using the iso-stoichiometric blending rule, is that they maintain a constant octane number, which has led to the introduction of methanol as a drop-in fuel to supplement bio-derived ethanol. A constant RON/HCCI fuel number/derived Research octane number property was observed in all three combustion modes for high RON fuels, but for low RON fuels, the iso-stoichiometric blending rule for constant octane number did not appear to be valid. The chemical composition and octane number of the base fuel also influenced the behavior of the GEM blends under different conditions.

Combined effect of protein and oxygen on reactive oxygen and nitrogen species in the plasma treatment of tissue

Science.gov (United States)

Gaur, Nishtha; Szili, Endre J.; Oh, Jun-Seok; Hong, Sung-Ha; Michelmore, Andrew; Graves, David B.; Hatta, Akimitsu; Short, Robert D.

2015-09-01

The influence of protein and molecular, ground state oxygen (O2) on the plasma generation, and transport of reactive oxygen and nitrogen species (RONS) in tissue are investigated. A tissue target, comprising a 1 mm thick gelatin film (a surrogate for real tissue), is placed on top of a 96-well plate; each well is filled with phosphate buffered saline (PBS, pH 7.4) containing one fluorescent or colorimetric reporter that is specific for one of three RONS (i.e., H2O2, NO2-, or OH•) or a broad spectrum reactive oxygen species reporter (2,7-dichlorodihydrofluorescein). A helium cold atmospheric plasma (CAP) jet contacts the top of the gelatin surface, and the concentrations of RONS generated in PBS are measured on a microplate reader. The data show that H2O2, NO2-, or OH• are generated in PBS underneath the target. Independently, measurements are made of the O2 concentration in the PBS with and without the gelatin target. Adding bovine serum albumin protein to the PBS or gelatin shows that protein either raises or inhibits RONS depending upon the O2 concentration. Our results are discussed in the context of plasma-soft tissue interactions that are important in the development of CAP technology for medicine, biology, and food manufacturing.

Auto-Ignition of Iso-Stoichiometric Blends of Gasoline-Ethanol-Methanol (GEM) in SI, HCCI and CI Combustion Modes

KAUST Repository

Waqas, Muhammad; Naser, Nimal; Sarathy, Mani; Feijs, Jeroen; Morganti, Kai; Nyrenstedt, Gustav; Johansson, Bengt

2017-01-01

Gasoline-ethanol-methanol (GEM) blends, with constant stoichiometric air-to-fuel ratio (iso-stoichiometric blending rule) and equivalent to binary gasoline-ethanol blends (E2, E5, E10 and E15 in % vol.), were defined to investigate the effect of methanol and combined mixtures of ethanol and methanol when blended with three FACE (Fuels for Advanced Combustion Engines) Gasolines, I, J and A corresponding to RON 70.2, 73.8 and 83.9, respectively, and their corresponding Primary Reference Fuels (PRFs). A Cooperative Fuel Research (CFR) engine was used under Spark Ignition and Homogeneous Charge Compression Ignited modes. An ignition quality tester was utilized in the Compression Ignition mode. One of the promising properties of GEM blends, which are derived using the iso-stoichiometric blending rule, is that they maintain a constant octane number, which has led to the introduction of methanol as a drop-in fuel to supplement bio-derived ethanol. A constant RON/HCCI fuel number/derived Research octane number property was observed in all three combustion modes for high RON fuels, but for low RON fuels, the iso-stoichiometric blending rule for constant octane number did not appear to be valid. The chemical composition and octane number of the base fuel also influenced the behavior of the GEM blends under different conditions.

Highlight: Ankara workshop puts minimum wage on the G-20 radar ...

International Development Research Centre (IDRC) Digital Library (Canada)

2016-04-14

Apr 14, 2016 ... A recent JustJobs Network workshop, held before the meetings of G-20 ... Network), and Nguyen Thang (Vietnam's Academy of Social Sciences) ... In all three cases, setting a minimum wage has also had negative effects.

"Of comics and men: A cultural history of American comic books," by Jean-Paul Gabilliet

Directory of Open Access Journals (Sweden)

Drew Morton

2013-06-01

Full Text Available Jean-Paul Gabilliet. Of comics and men: A cultural history of American comic books. Translated by Bart Beaty and Nick Nguyen. Jackson: University Press of Mississippi, 2010, hardcover, $55.00 (390p, ISBN 978-1604732672.

Elemental analysis of the ancient bronze coins by x-ray fluorescence technique using simultaneously radioisotope source and x-ray tube

International Nuclear Information System (INIS)

Nguyen The Quynh; Truong Thi An; Tran Duc Thiep; Nguyen Dinh Chien; Dao Tran Cao; Nguyen Quang Liem

2004-01-01

The results on elemental analysis of the Vietnamese ancient bronze coins during the time of the Nguyen dynasty (19th century) are presented. The samples were provided by the vietnam National Historical Museum and the elemental analysis was performed on the home-made model EDS-XT-99-01 X-ray fluorescence spectrometer in the Institute of Materials Science, NCST of Vietnam. The samples exited simultaneously by radioisotope source and X-ray tube. The analytical results show the similarity in the elemental composition of the coins issued by different kings of the Nguyen dynasty, but there is the difference in the concentration of the used elements. Another interesting point is that all the coins have zinc (Zn) in their composition, which shows clearly the influence of the occidental metallurgical technology on the money-making technique in Vietnam during the 19th century. (author)

Bruce Power - the first 24 exciting months

International Nuclear Information System (INIS)

Mottram, R.

2003-01-01

In this presentation, Ron Mottram will review the 2 year business evolution since the inception of Bruce Power - Ontario's largest independent electricity generator. Mr. Mottram will provide an overview of the Bruce Power business and operating history, along with specific emphasis on the project to Restart Bruce Units 3 and 4. Ron will share many of the project successes and challenges, and will provide insight into the myriad of issues faced by a large multi-faceted project of this type. (author)

Ombuds' Corner: Team spirit and rumours

CERN Document Server

Vincent Vuillemin

2011-01-01

Jeff* is the leader of a team in charge of the support, operation and maintenance of many CERN equipment. The task is complex as the equipment is scattered across the CERN site, and needs regular maintenance and constant operational monitoring. His team is formed of CERN staff and technicians working under external service contracts.   For a long time everything ran smoothly, up to the point when a sudden and unexpected fault brought normal operations to a halt. Two colleagues, Ron* and Mike*, both CERN staff, were jointly responsible for the equipment concerned. Although the repairs were completed promptly, unpleasant rumours started to spread that the fault was due to previous maintenance work. Mike found out, by accident, that these false rumours had arisen from private conversations Ron had had with some technicians. Taking it as a personal attack, he started to spread gossip about Ron, making veiled accusations that he alone was responsible for the incident. Both rumours eventually reached e...

Ignition delay time measurements of primary reference fuel blends

KAUST Repository

Alabbad, Mohammed

2017-02-07

Ignition delay times of four different primary reference fuels (PRF), mixtures of n-heptane and iso-octane, were measured behind reflected shock waves in a high-pressure shock tube facility. The PRFs were formulated to match the RON of two high-octane gasolines (RON 95 and 91) and two prospective low-octane naphtha fuels (RON 80 and 70). Experiments were carried out over a wide range of temperatures (700–1200K), pressures (10, 20, and 40bar) and equivalence ratios (0.5 and 1). Kinetic modeling predictions from four chemical kinetic mechanisms are compared with the experimental data. Ignition delay correlations are developed to reproduce the measured ignition delay times. Brute force sensitivity analyses are carried out to identify reactions that affect ignition delay times at specific temperature, pressure and equivalence ratio. The large experimental data set provided in the current work will serve as a benchmark for the validation of chemical kinetic mechanisms of primary reference fuel blends.

Ignition delay time measurements of primary reference fuel blends

KAUST Repository

Alabbad, Mohammed; Javed, Tamour; Khaled, Fathi; Badra, Jihad; Farooq, Aamir

2017-01-01

Ignition delay times of four different primary reference fuels (PRF), mixtures of n-heptane and iso-octane, were measured behind reflected shock waves in a high-pressure shock tube facility. The PRFs were formulated to match the RON of two high-octane gasolines (RON 95 and 91) and two prospective low-octane naphtha fuels (RON 80 and 70). Experiments were carried out over a wide range of temperatures (700–1200K), pressures (10, 20, and 40bar) and equivalence ratios (0.5 and 1). Kinetic modeling predictions from four chemical kinetic mechanisms are compared with the experimental data. Ignition delay correlations are developed to reproduce the measured ignition delay times. Brute force sensitivity analyses are carried out to identify reactions that affect ignition delay times at specific temperature, pressure and equivalence ratio. The large experimental data set provided in the current work will serve as a benchmark for the validation of chemical kinetic mechanisms of primary reference fuel blends.

Obituary: Ronald A. Parise, 1951-2008

Science.gov (United States)

Gull, Theodore R.

2009-01-01

Ronald A. Parise, astronomer and astronaut, passed away at his home in Burtonsville, Maryland, in the presence of his family on 9 May 2008. He died of a brain tumor at age 56 after several years of valiant struggle. He was an inspiration to many students, ham operators, astronomers, and friends the world over. His enthusiasm for astronomy and space exploration was infectious. We, colleagues at Goddard Space Flight Center and Computer Sciences Corporation, treasured his contributions to space astronomy and human spaceflight. Ron, along with Samuel Durrance, flew as Payload Specialist on Astro-1 and Astro-2. They were selected by peers from the instrument teams of the Hopkins Ultraviolet Telescope (HUT provided by Hopkins University), the Ultraviolet Imaging Telescope (UIT, Goddard Space Flight Center) and the Wisconsin Ultraviolet Photo-Polarimetry Experiment (WUPPE, University of Wisconsin). Astro-1 flew 2-10 December 1990 on the Columbia. Astro-2 flew 2-18 March 1995. Ron carried along amateur radio equipment and operated on the air during his free time during the missions. Ron was born 24 May 1951 in Warren, Ohio, to Henry and Catherine Parise. His interests first were in amateur radio, becoming a licensed operator by age eleven. He later was attracted to both astronomy and aviation, becoming a pilot in his teens. Ron graduated from Western Reserve High School in 1969 and attended Youngstown State University where he received a bachelor of science degree in physics with minors in mathematics, astronomy. and geology. His graduate work was at University of Florida where he obtained a masters degree in 1977 and a doctorate in 1979 in astronomy. Ron joined Operations Research, Inc. upon graduation, working at Goddard Space Flight Center where he supported studies of several NASA missions. In 1980 he joined Computer Sciences Corporation supporting the International Ultraviolet Explorer [IUE], first as a data-management scientist and later as the section manager of the

Understanding the Dynamic System of Terrorist-Government Interaction

Science.gov (United States)

2003-03-01

Figure 62. Model 5D Equation Level Screen Shot 3 167 Bibliography Bajaracharya, Arun, Stephen Olu Ogunlana, and Nguyen Luong Bach...Understanding the New Security Environment Readings and Interpretations. Guilford, Connecticut: Mc- Graw -Hill/Dushkin 2002 Laqueur, Walter. “Postmodern

QTL Information Table: 499 [Q-TARO

Lifescience Database Archive (English)

Full Text Available 66 A RG476 RG214 pha Kamoshita, A., Zhang, J., Siopongco, J., Sarkarung, S., Nguyen, H.T., and Wade, L.J. (2002). Effects of Phenotyp...ing Environment on Identification of Quantitative Trait Loci for Rice Root Morpholo

Extraction-condition Optimization of Baicalein and Schisandrin from ...

African Journals Online (AJOL)

effects of individual factors on extraction rates of baicalein and schisandrin determined by high performance liquid ..... Huang HL, Wang YJ, Zhang QY, Liu B, Wang FY, Li JJ,. Zhu RZ. ... Liu C, Zhao X, Fan Y, Han G, Nguyen T. Astragalus.

AUTHOR INDEX

Indian Academy of Sciences (India)

Arumugam M. Optical fiber communication – An overview. 849. Arumugam P ... Spinning solitons in cubic-quintic nonlinear media. 1041. Dang Nguyen Dinh. E1 resonances in .... Measuring the top quark mass in the eµ chan- nel: A study. 689.

Effects of Apis mellifera adansonii, L. 1758 (Apidae: Hymenoptera ...

African Journals Online (AJOL)

Effects of Apis mellifera adansonii, L. 1758 (Apidae: Hymenoptera) pollination on yields of Cucumeropsis mannii (Naudin) in Kisangani, Democratic Republic of Congo. Boniface Posho Ndola, Yves Brostaux, Guillaume Le Goff, Marie-Lucie Susini, Eric Haubruge, Frederic Francis, Bach Kim Nguyen ...

A blending rule for octane numbers of PRFs and TPRFs with ethanol

KAUST Repository

AlRamadan, Abdullah S.

2016-04-12

Ethanol is widely used as an octane booster in commercial gasoline fuels. Its oxygenated nature aids in reducing harmful emissions such as nitric oxides (NOx), soot and unburned hydrocarbons (HC). However, the non-linear octane response of ethanol blending with gasoline fuels is not completely understood because of the unknown intermolecular interactions in such blends. In general, when ethanol is blended with gasoline, the Research Octane Number (RON) and the Motor Octane Number (MON) non-linearly increase (synergistic) or decrease (antagonistic), and the non-linearity depends on the composition of the base gasoline. The complexity of commercial gasoline, comprising of hundreds of different components, makes it challenging to understand ethanol-gasoline synergistic/antagonistic blending effects. Understanding ethanol blending effects with simpler gasoline surrogates blends may enable a better understanding of ethanol blending with complex multi-component gasoline fuels. This study presents a blending rule to predict the octane numbers (ON) of ethanol/primary reference fuel (PRF; mixtures of iso-octane and n-heptane) and ethanol/toluene primary reference fuel (TPRF; mixtures of toluene, iso-octane and n-heptane) mixtures using the data available in literature and new data. The ON of ethanol blends with PRF-40, -50, and -60 were measured and compared with those from literature. Additional experimental data were collected to validate the developed model for ethanol blends of three different TPRFs having the same RON but different MON (i.e., different toluene contents). The three tested TPRF mixtures have octane ratings of RON 60.0/MON 58.0 (toluene 10.2 vol%), RON 60.0/MON 56.3 (toluene 19.8 vol%), and RON 60.0/MON 53.2 (toluene 40.2 vol%). The octane prediction model consists of linear and non-linear by mole regions. The transition point between the linear and non-linear regions is a function of the RON and MON of the base PRF and TPRF mixture. The non-linear by

SSC San Diego Command History Calendar Year 2007

Science.gov (United States)

2008-03-01

Camargo , Sylvia Salazar, Karen Manley-Guerrero, Dina Demuth, Clay Oeholke, Gannon Graue, Dee Johnson, Erwin Mier, Hoa Nguyen. Navy Multiband Terminal...Davenport, Brian Devine, Greg Doriguzzi, Richard Felkins, John Fleming, Cheryl Francisco , Sid Graser, Eric Hillis, Craig LaMaster, Susan Manor, Joel

Second language writing and literary reading in university: three empirical studies

NARCIS (Netherlands)

Nguyen, P.N.T.

2012-01-01

Het leren van Engels als tweede taal is voor Aziatische en Vietnamese studenten zinvol en effectief als rekening wordt gehouden met een aantal uitdagingen, die meestal worden veroorzaakt door hun historische en culturele achtergrond. Phuong Nam Nguyen onderzocht hoe leeractiviteiten bij Aziatische

Fulltext PDF

Indian Academy of Sciences (India)

Unknown

negative Cauchy, for example, in the case of titanium aluminides ... bounded BOPs theory (Nguyen-Manh et al 2000; Pettifor ..... Figure 4. γ-surface for (111) plane in mJ/m2: (a) surface plot and (b) contour plot. ..... bonding in layered materials.

Advanced Fuels and Combustion Processes for Propulsion

Science.gov (United States)

2010-09-01

production from biomass steam reforming – Conduct a feasibility analysis of the proposed integrated process Energia Technologies - D. Nguyen & K. Parimi...strength foam material development by Ultramet – Combustion experiments performed U. Of Alabama – End-user input provided by Solar Turbines Major

Fuzzy controller for better tennis ball robot | Nguyen | Journal of ...

African Journals Online (AJOL)

This paper aims at designing a tennis ball robot as a training facility for tennis players. The robot is built with fuzzy controller which provides proper techniques for the players to gain practical experience as well as technical skills; thus, it can effectively serve the community and train athletes in the high-performance sport.

76 FR 44330 - Ocean Transportation Intermediary License Applicants

Science.gov (United States)

2011-07-25

.... Nguyen, Secretary/CFO, Application Type: New NVO & OFF License. Atlas Logistics LLC (NVO & OFF), 2801 NW...), Application Type: New NVO & OFF License. Bulk Cargo Services & Logistics Inc. (OFF), 15400 N.E. 103rd Drive..., Member/Chief Executive Manager, (Qualifying Individual), Stina Storr, Member/ Managing Member...

Two new species of the genus Pararrhynchium de Saussure (Hymenoptera: Vespidae: Eumeninae) from northern Vietnam.

Science.gov (United States)

Nguyen, Lien Thi Phuong

2015-06-22

Two new species of the genus Pararrhynchium are described and figured: P. striatum sp. nov. (northern Vietnam: Hoa Binh, Ha Tinh and Thai Nguyen) and P. concavum sp. nov. (northern Vietnam: Cao Bang). A key to all known species of the genus is provided.

75 FR 4428 - Sunshine Act Meeting Notice

Science.gov (United States)

2010-01-27

....m. Briefing on Uranium Recovery (Public Meeting). (Contact: Dominick Orlando, 301-415-6749.) This... NUCLEAR REGULATORY COMMISSION [NRC-2010-0002] Sunshine Act Meeting Notice DATES: Weeks of January... Plans (Public Meeting). (Contact: Quynh Nguyen, 301-415-5844.) This meeting will be webcast live at the...

International Journal of Biological and Chemical Sciences - Vol 11 ...

African Journals Online (AJOL)

... L. 1758: Hymenoptera, Apidae) in three beekeeping sites of the Democratic Republic of Congo · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Boniface Posho Ndola, Paul Malumba, Bernard Wathelet, Eric Haubruge, Frederic Francis, Bach Kim Nguyen, 541-555.

2018-03-18T16:42:18Z https://www.ajol.info/index.php/index/oai oai ...

African Journals Online (AJOL)

article/55645 2018-03-18T16:42:18Z ajrh:ART Gender dynamics and sexual norms among youth in Mali in the context of HIV/AIDS prevention Boileau, C Vissandjee, B Nguyen, V-K Rashed, S Sylla, M Zunzunegui, MV Gender roles, sexual ...

78 FR 8544 - National Center for Advancing Translational Sciences (NCATS): Cooperative Research and...

Science.gov (United States)

2013-02-06

... background technology should be addressed to Lauren Nguyen-Antczak, Ph.D., Licensing and Patenting Manager... expression, and overall tissue homeostasis; (3) a moderation of inflammation by reducing levels of... candidate selection including all aspects of pre-clinical studies such as toxicity studies, and chemistry...

Identity, causality, and pronoun ambiguity.

Science.gov (United States)

Sagi, Eyal; Rips, Lance J

2014-10-01

This article looks at the way people determine the antecedent of a pronoun in sentence pairs, such as: Albert invited Ron to dinner. He spent hours cleaning the house. The experiment reported here is motivated by the idea that such judgments depend on reasoning about identity (e.g., the identity of the he who cleaned the house). Because the identity of an individual over time depends on the causal-historical path connecting the stages of the individual, the correct antecedent will also depend on causal connections. The experiment varied how likely it is that the event of the first sentence (e.g., the invitation) would cause the event of the second (the house cleaning) for each of the two individuals (the likelihood that if Albert invited Ron to dinner, this would cause Albert to clean the house, versus cause Ron to clean the house). Decisions about the antecedent followed causal likelihood. A mathematical model of causal identity accounted for most of the key aspects of the data from the individual sentence pairs. Copyright © 2014 Cognitive Science Society, Inc.

A breakdown enhanced AlGaN/GaN MISFET with source-connected P-buried layer

Science.gov (United States)

Luo, Xin; Wang, Ying; Cao, Fei; Yu, Cheng-Hao; Fei, Xin-Xing

2017-12-01

This paper presents a breakdown-enhanced AlGaN/GaN MISFET with a source-connected P-buried layer combined with field plates (SC-PBL FPs MISFET). A TCAD tool was used to analyze the breakdown characteristics of the proposed structure, and results show that in comparison to the conventional gate field plate MISFET (GFP-C MISFET), the proposed structure provides a significant increase of breakdown voltage (VBK) due to redistribution of electric field in the gate-drain region induced by the SC-PBL and the FPs. The optimized SC-PBL FPs MISFET with a gate-drain spacing of 6 μm achieved a high Baliga's figure of merit of 2.6 GW cm-2 with a corresponding breakdown voltage (VBK) of 1311.62 V and specific on resistance (RON,sp) of 0.66 mΩ cm2, which demonstrates a good trade-off between RON,sp and VBK compared to the GFP-C MISFET with VBK of 524.27 V and RON,sp of 0.61 mΩ cm2.

EXPLORING THE USE OF SUEDE DYE ON LEATHER

African Journals Online (AJOL)

User

Nguyen (2007) that almost all the world output of leather is produced ... The experiment on the use of suede dye on leather was done in three formats. In the first format, suede ... warm water in a plastic container in the first instance. Alum is a ...

Rezhissjor Ron Hauard : ja snimal "Kod da Vinsthi" ne dlja teh, kto tshital roman / Ron Howard ; interv. Stass Tõrkin

Index Scriptorium Estoniae

Howard, Ron

2006-01-01

6. mai ajalehes ilmunud intervjuu järg. Filmi "Da Vinci kood" võtetest Louvre'is, Lincolni katedraalis ja raamatu autori Dan Browni suhtumisest ekraniseeringusse. Ajakirjanikele näidatud filmikatked : "Kak rozhala Maria Magdalina"

Compatibility Grab Sampling and Analysis Plan for FY 2000

International Nuclear Information System (INIS)

SASAKI, L.M.

1999-01-01

This sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for grab samples obtained to address waste compatibility. It is written in accordance with requirements identified in Data Quality Objectives for Tank Farms Waste Compatibility Program (Mulkey et al. 1999) and Tank Farm Waste Transfer Compatibility Program (Fowler 1999). In addition to analyses to support Compatibility, the Waste Feed Delivery program has requested that tank samples obtained for Compatibility also be analyzed to confirm the high-level waste and/or low-activity waste envelope(s) for the tank waste (Baldwin 1999). The analytical requirements to confirm waste envelopes are identified in Data Quality Objectives for TWRS Privatization Phase I: Confirm Tank T is an Appropriate Feed Source for Low-Activity Waste Feed Batch X (Nguyen 1999a) and Data Quality Objectives for RPP Privatization Phase I: Confirm Tank T is an Appropriate Feed Source for High-Level Waste Feed Batch X (Nguyen 1999b)

Refining a definition of reflection for the being as well as doing the work of a physician.

Science.gov (United States)

Wald, Hedy S

2015-04-21

Reflection is core to professional competency and supports the active, constructive process of professional identity formation. Medical educators thus grapple with operationalizing and effectively integrating reflection as a foundational construct within health care professions education and practice. Core elements of reflection including role of emotions and awareness of self, other and situation, do not appear within various working definitions of reflection. This observation as well as noted recent shift in medical education toward emphasis on the "being" as well as "doing the work" of a physician led to the author's proposed refining of Sandars' reflection definition and expansion of Nguyen et al.'s reflection model. A refined reflection definition is offered for a more inclusionary approach. A caveat regarding potential for expected reflective learning outcomes (given reflection as a process) is provided and the integral role of mentor-enhanced reflection is discussed. Reflection as a continuum is highlighted and exemplified within Wald et al.'s REFLECT rubric and Nguyen et al.'s reflection model.

Bilateral retrobulbar optic neuropathy as the only sign of zoledronic acid toxicity.

Science.gov (United States)

Lavado, Félix Manco; Prieto, Marta Para; Osorio, María Rosalba Ramoa; Gálvez, María Isabel López; Leal, Lucía Manzanas

2017-10-01

Bisphosphonates may rarely cause ocular adverse effects and retrobulbar optic neuropathy (RON) secondary to zoledronic acid is very rare. A 67-year-old man was referred because of progressive and painless decrease vision in the left eye. He had been treated with 7 cycles of zoledronic acid infusions because of metastatic prostate cancer. On examination, VA was 20/20 in the right eye (OD) and 20/50 in the left eye (OS). The optic nerve was unremarkable OU. Pattern visual evoked potentials (pVEP) and electroretinography were performed with the result of VEP responses abolished in OS, and the VEP waveform within the normal range amplitude and delayed peak latencies in OD. Due to the high suspicion of bilateral RON secondary to zoledronic acid, we decided to discontinue the treatment. Two months later, VA was 20/20 OD and hand motions OS, with relative afferent pupillary defect and a pallor of the optic disc in OS. The diagnosis of bilateral RON secondary to zoledronic acid infusions was confirmed, and it was only partially reversible. Zoledronic acid is a potent new generation bisphosphonate increasingly used in oncologic patients and it is usually well tolerated. Optic nerve toxicity is not a side effect recognised by either the Food and Drug Administration or the drug manufacturers, and to our knowledge, this is the first case of zoledronic acid-related bilateral RON with late onset. In conclusion, patients treated with bisphosphonates should be informed about the possibility of ocular side-effects, and ophthalmologists should be consider discontinuing the drug. Copyright © 2017 Elsevier Ltd. All rights reserved.

Analysing movements in investor’s risk aversion using the Heston volatility model

Directory of Open Access Journals (Sweden)

Alexie ALUPOAIEI

2013-03-01

Full Text Available In this paper we intend to identify and analyze, if it is the case, an “epidemiological” relationship between forecasts of professional investors and short-term developments in the EUR/RON exchange rate. Even that we don’t call a typical epidemiological model as those ones used in biology fields of research, we investigated the hypothesis according to which after the Lehman Brothers crash and implicit the generation of the current financial crisis, the forecasts of professional investors pose a significant explanatory power on the futures short-run movements of EUR/RON. How does it work this mechanism? Firstly, the professional forecasters account for the current macro, financial and political states, then they elaborate forecasts. Secondly, based on that forecasts they get positions in the Romanian exchange market for hedging and/or speculation purposes. But their positions incorporate in addition different degrees of uncertainty. In parallel, a part of their anticipations are disseminated to the public via media channels. Since some important movements are viewed within macro, financial or political fields, the positions of professsional investors from FX derivative market are activated. The current study represents a first step in that direction of analysis for Romanian case. For the above formulated objectives, in this paper different measures of EUR/RON rate volatility have been estimated and compared with implied volatilities. In a second timeframe we called the co-integration and dynamic correlation based tools in order to investigate the relationship between implied volatility and daily returns of EUR/RON exchange rate.

Ibsen's Plays in China And Their Ethical Value:A Speech at the Closing Ceremony of the Third International Ibsen Conference in China

Institute of Scientific and Technical Information of China (English)

Nie Zhenzhao

2005-01-01

This is a speech delivered at the closing ceremony of The Third International Ibsen Conference in China, which introduces some people and their studies on Ibsen in China, and takes A Doll's House as an example for an ethical analysis. The speech chooses Professor Wang Zhongxiang, Professor Kwok-kan Tam, Professor Knut Brynhildsvoll and others for an evaluation of their studies as the evidence of achievements in the Ibsen studies in the New Period in China. The speech, from the perspective of ethical literary criticism, also analyses A Doll's House as a moral play to raise moral questions and concludes that Ibsen's so-called social problem plays are ethical problem ones.

CERN – better than science fiction!

CERN Multimedia

2007-01-01

From left to right: Allan Cameron (Production Designer), Sam Breckham (Location Manager), James Gillies (Head of Communication at CERN), Jacques Fichet (from the CERN Audiovisual Service), Rolf Landua (former spokesman of the ATHENA antihydrogen experiment at CERN and Head of CERN’s Education Group), Ron Howard, and Renilde Vanden Broeck (CERN press officer). The two-time Academy Award-winning American film director, Ron Howard, recently visited CERN for background research in preparation for his new film Angels and Demons, based on the book by Dan Brown. He also filmed the adaption of Brown’s bestselling novel The Da Vinci Code last year.

Hayes Receives 2012 Ronald Greeley Early Career Award in Planetary Science: Response

Science.gov (United States)

Hayes, Alexander G.

2013-10-01

I am deeply honored to be the inaugural recipient of the Ronald Greeley Early Career Award. Ron was an icon in the field of planetary science, and the establishment of this award is a fitting way to pay tribute to his legacy. I applaud Laurie Leshin, Bill McKinnon, and the rest of the AGU Planetary Science section officers and selection committee for taking the time to organize this memorial. Ron is remembered not only for his fundamental scientific contributions but also for his mentorship and support of early-career scientists, both his own students and postdocs and those of his colleagues.

Riflessioni sulla ricezione di Goldoni nel '700 francese

DEFF Research Database (Denmark)

Olsen, Michel

2011-01-01

This essay takes up the relative incomprehension experienced in France by Goldoni, as before him by the great Dano-norwegian comedy-writer Ludwig Holberg. An exception was Élie Fréron, known as the antagonist of the philosophes, but rediscovered in the last decades of the last century as a brilli......This essay takes up the relative incomprehension experienced in France by Goldoni, as before him by the great Dano-norwegian comedy-writer Ludwig Holberg. An exception was Élie Fréron, known as the antagonist of the philosophes, but rediscovered in the last decades of the last century...

A Biophysico-computational Perspective of Breast Cancer Pathogenesis and Treatment Response

Science.gov (United States)

2006-03-01

obtained a lysyl oxidase antibody as well as an expression construct to a constitutively active lysyl oxidase and BAPN compound which is a specific...cell viability. Mol Biol Cell, 2002. 13(8): p. 2933-45. 19. Nguyen, K.T. and J.L. West, Photopolymerizable hydrogels for tissue engineering applications

Increased Expression of the Chemokines CXCL1 and MIP-1a by Resident Brain Cells Precedes Neutrophil Infiltration in the Brain Following Prolonged Soman-Induced Status Epilepticus in Rats

Science.gov (United States)

2011-05-01

brain cytokine concentrations. J Neuroinflammation 2010, 7:40. 12. Manley NC, Bertrand AA, Kinney KS, Hing TC, Sapolsky RM: Characterization of monocyte...neurodegeneration. J Neurosci 2007, 27:9301-9309. 16. Wolpe SD, Davatelis G, Sherry B, Beutler B, Hesse DG, Nguyen HT, Moldawer LL , Nathan CF, Lowry SF

Enhancing the Breadth and Efficacy of Therapeutic Vaccines for Breast Cancer

Science.gov (United States)

2015-10-01

REPORTABLE OUTCOMES: None OTHER ACHIEVEMENTS: No other achievements to report. REFERENCES: 1. Wolfl M, Kuball J, Ho WY, Nguyen H, Manley TJ...Valiante NM, Chen L, Lee C, Gumperz JE, Phillips JH, Lanier LL , Bigge JC, Parekh RB, Parham P. The inter-locus recombinant HLA-B*4601 has high

dinh quang khieu

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. DINH QUANG KHIEU. Articles written in Bulletin of Materials Science. Volume 41 Issue 1 February 2018 pp 6. Lead ions removal from aqueous solution using modified carbon nanotubes · NGUYEN DUC VU QUYEN TRAN NGOC TUYEN DINH QUANG KHIEU HO VAN MINH ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. TRAN NGOC TUYEN. Articles written in Bulletin of Materials Science. Volume 41 Issue 1 February 2018 pp 6. Lead ions removal from aqueous solution using modified carbon nanotubes · NGUYEN DUC VU QUYEN TRAN NGOC TUYEN DINH QUANG KHIEU HO VAN MINH ...

Optimizing culture conditions for the production of endo-β-1,4 ...

African Journals Online (AJOL)

GREGORY

2010-09-20

Sep 20, 2010 ... Vietnam Type Culture Collection (VTCC)-F099. Van Tuan Nguyen and Dinh Thi Quyen. Institute of Biotechnology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Distr. Caugiay, ... sources (coconut fiber, coffee shell, corncob, dried tangerine skin, peanut shell, rice bran, saw dust,.

PHAM THI NGOC LAN

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. PHAM THI NGOC LAN. Articles written in Bulletin of Materials Science. Volume 41 Issue 1 February 2018 pp 6. Lead ions removal from aqueous solution using modified carbon nanotubes · NGUYEN DUC VU QUYEN TRAN NGOC TUYEN DINH QUANG KHIEU HO VAN MINH ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Author Affiliations. N D Sang1 P H Quang2 L T Tu2 D T B Hop2. National University of Civil Engineering, 55 Giai Phong Street, Hai Ba Trung, Hanoi, Vietnam; Hanoi University of Science, Vietnam National University, Hanoi, 334 Nguyen Trai, Thanh Xuan, Hanoi, Vietnam ...

Effect of Temperature on Mechanical Properties of Nanoclay Reinforced Polymeric Nanocomposites. Part 1. Experimental Results

Science.gov (United States)

2012-04-23

Sugiyama, T. Kurashi, O. Kamigaito., U.S. 4,739,007 (1998). UNCLASSIFIED 22 [4] Nguyen Q. T., Process for Improving Exfoliation and Dispersion of...polyethylene/ Kaolin composites. Part II. Thermoelastic behavior of blow-molded samples. J Mater Sci 34 (1999), pp. 497–508. [22] J.S. Bergman, H

L'université en transition

International Development Research Centre (IDRC) Digital Library (Canada)

Nguyen Vo Hung Institut national pour études sur la politique et la stratégie S&T ..... de concentration a été renforcé par des stratégies offensives de recrutement de la ..... On a pu assister dans le même temps à la croissance des entreprises ...

JPRS Report East Asia Southeast Asia

Science.gov (United States)

1987-06-30

uti - lization of natural resources." "The, Stale shall from lime.1.6 lime, review to upgrade pensions and other benefits due to retirees of both the...VIETNAM RATIONAL, INTENSIVE EXPORT OF PHARMACEUTICALS PROPOSED Hanoi NHAN DAN in Vietnamese 14 Apr 87 p 3 [Article by pharmacist Nguyen Duy Cuong

Uterine-Specific Knockout of Tsc-2: A Mouse Model for Lymphangioleiomyomatosis

Science.gov (United States)

2013-10-01

Burlingame, Califor- nia ), anti-phospho-S6 (Ser 235/236), anti-S6 and 1:5000 anti- glyceraldehyde-3-phosphate dehydrogenase (GAPDH; Cell Sig- naling...Olson S, Nguyen TA. Hydronephrosis and urine retention in estrogen-implanted athymic nude mice. Vet Pathol. 2009;46(3): 505 –508. 40. Leavitt WW, Takeda

Genetics Home Reference: carbonic anhydrase VA deficiency

Science.gov (United States)

... Salvarinova R, Yaplito-Lee J, Santra S, Shyr C, Horvath GA, Eydoux P, Lehman AM, Bernard V, Newlove T, Ukpeh H, Chakrapani A, Preece MA, Ball S, Pitt J, Vallance HD, Coulter-Mackie M, Nguyen H, Zhang LH, Bhavsar AP, Sinclair G, Waheed A, Wasserman WW, Stockler-Ipsiroglu S. Mitochondrial carbonic ...

Gender | Page 13 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

mHealth programs for ethnic minority women in Vietnam bring information on pregnancy and newborn care closer. Photo: Nguyen Thi Thanh Ha / PHAD. Read more about Connecting Vietnam's isolated communities to improve healthcare. Language English. Des initiatives de cybersanté améliorent l'accès des femmes à ...

Health | Page 2 | IDRC - International Development Research Centre

International Development Research Centre (IDRC) Digital Library (Canada)

mHealth programs for ethnic minority women in Vietnam bring information on pregnancy and newborn care closer. Photo: Nguyen Thi Thanh Ha / PHAD. Read more about Connecting Vietnam's isolated communities to improve healthcare. Language English. Des initiatives de cybersanté améliorent l'accès des femmes à ...

National Guard Posture Statement 2010. America’s Indispensable Force

Science.gov (United States)

2010-01-01

remote-controlled camera to watch for illegal border crossers, smugglers, and other suspicious activity during Operation Jump Start. Did you Know... Neubauer , CA SPC Joshua M. Neusche, MO SGT Long N. Nguyen, OR SPC Paul A. Nicholas, CA SFC Scott E. Nisely, IA SGT William J. Normandy, VT PFC Francis C

Lipoteichoic acid from Staphylococcus aureus induces lung endothelial cell barrier dysfunction: role of reactive oxygen and nitrogen species.

Directory of Open Access Journals (Sweden)

Amy Barton Pai

Full Text Available Tunneled central venous catheters (TCVCs are used for dialysis access in 82% of new hemodialysis patients and are rapidly colonized with Gram-positive organism (e.g. Staphylococcus aureus biofilm, a source of recurrent infections and chronic inflammation. Lipoteichoic acid (LTA, a cell wall ribitol polymer from Gram-positive organisms, mediates inflammation through the Toll-like receptor 2 (TLR2. The effect of LTA on lung endothelial permeability is not known. We tested the hypothesis that LTA from Staphylococcus aureus induces alterations in the permeability of pulmonary microvessel endothelial monolayers (PMEM that result from activation of TLR2 and are mediated by reactive oxygen/nitrogen species (RONS. The permeability of PMEM was assessed by the clearance rate of Evans blue-labeled albumin, the activation of the TLR2 pathway was assessed by Western blot, and the generation of RONS was measured by the fluorescence of oxidized dihydroethidium and a dichlorofluorescein derivative. Treatment with LTA or the TLR2 agonist Pam((3CSK((4 induced significant increases in albumin permeability, IκBα phosphorylation, IRAK1 degradation, RONS generation, and endothelial nitric oxide synthase (eNOS activation (as measured by the p-eNOS(ser1177:p-eNOS(thr495 ratio. The effects on permeability and RONS were effectively prevented by co-administration of the superoxide scavenger Tiron, the peroxynitrite scavenger Urate, or the eNOS inhibitor L-NAME and these effects as well as eNOS activation were reduced or prevented by pretreatment with an IRAK1/4 inhibitor. The results indicate that the activation of TLR2 and the generation of ROS/RNS mediates LTA-induced barrier dysfunction in PMEM.

Mechanisms of Plasma Therapeutics

Science.gov (United States)

Graves, David

2015-09-01

In this talk, I address research directed towards biomedical applications of atmospheric pressure plasma such as sterilization, surgery, wound healing and anti-cancer therapy. The field has seen remarkable growth in the last 3-5 years, but the mechanisms responsible for the biomedical effects have remained mysterious. It is known that plasmas readily create reactive oxygen species (ROS) and reactive nitrogen species (RNS). ROS and RNS (or RONS), in addition to a suite of other radical and non-radical reactive species, are essential actors in an important sub-field of aerobic biology termed ``redox'' (or oxidation-reduction) biology. It is postulated that cold atmospheric plasma (CAP) can trigger a therapeutic shielding response in tissue in part by creating a time- and space-localized, burst-like form of oxy-nitrosative stress on near-surface exposed cells through the flux of plasma-generated RONS. RONS-exposed surface layers of cells communicate to the deeper levels of tissue via a form of the ``bystander effect,'' similar to responses to other forms of cell stress. In this proposed model of CAP therapeutics, the plasma stimulates a cellular survival mechanism through which aerobic organisms shield themselves from infection and other challenges.

Aqueous reactive species induced by a PCB surface micro-discharge air plasma device: a quantitative study

Science.gov (United States)

Chen, Chen; Li, Fanying; Chen, Hai-Lan; Kong, Michael G.

2017-11-01

This paper presents a quantitative investigation on aqueous reactive species induced by air plasma generated from a printed circuit board surface micro-discharge (SMD) device. Under the conditions amenable for proliferation of mammalian cells, concentrations of ten types of reactive oxygen and nitrogen species (RONS) in phosphate buffering solution (PBS) are measured by chemical fluorescent assays and electron spin resonance spectroscopy (ESR). Results show that concentrations of several detected RNS (NO2- , NO3- , peroxynitrites, and NO2\\centerdot ) are higher than those of ROS (H2O2, O2\\centerdot - , and 1O2) in the air plasma treated solution. Concentrations of NO3- can reach 150 times of H2O2 with 60 s plasma treatment. For short-lived species, the air plasma generates more copious peroxynitrite than other RONS including NO2\\centerdot , O2\\centerdot - , 1O2, and N{{O}\\centerdot } in PBS. In addition, the existence of reaction between H2O2 and NO2- /HNO2 to produce peroxynitrite is verified by the chemical scavenger experiments. The reaction relations between detected RONS are also discussed.

A new green approach for the reduction of graphene oxide ...

Indian Academy of Sciences (India)

Author Affiliations. Thu Ha Thi Vu1 Thanh Thuy Thi Tran1 Hong Ngan Thi Le1 Phuong Hoa Thi Nguyen1 Ngoc Quynh Bui2 Nadine Essayem2. Key Laboratory for Petrochemical and Refinery Technologies, Hanoi, Vietnam; Institute of Researches on Catalysis and Environment in Lyon, CNRS, Lyon 1, 69626 Villeurbanne, ...

Collaborative Learning. Research to Practice Brief

Science.gov (United States)

Lawrence, K. S.

2016-01-01

A Fully Integrated Educational System practices collaborative learning among all peers. The study summarized in this report (Zhang, X., Anderson, R. C., Morris, J., Miller, B., Nguyen-Janiel, K. T., Lin, T., Zhang, J., Jadallah, M., Scott, T., Sun, J., Latawjec, B., Ma, S., Grabow, K., & Hsu, J. Y. (2016). "Improving children's competence…

Prevalence and predictors of depressive symptoms among HIV-positive men who inject drugs in Vietnam.

Science.gov (United States)

Levintow, Sara N; Pence, Brian W; Ha, Tran Viet; Minh, Nguyen Le; Sripaipan, Teerada; Latkin, Carl A; Vu, Pham The; Quan, Vu Minh; Frangakis, Constantine; Go, Vivian F

2018-01-01

HIV infection is common among people who inject drugs (PWID), and HIV-positive PWID may be particularly vulnerable to depression. This study measured the prevalence of depressive symptoms and the factors associated with severe symptoms among 455 HIV-positive PWID in Thai Nguyen, Vietnam. We used cross-sectional data from PWID in a randomized controlled trial of an intervention to reduce high-risk injecting and sexual behaviors in Thai Nguyen from 2009-2013. Depressive symptoms were measured with the Center for Epidemiologic Studies Depression Scale (CES-D). We used logistic regression to assess demographic, clinical, and psychosocial predictors of severe depressive symptoms (CES-D≥23) with prevalence odds ratios (POR) and 95% confidence intervals (CI). The prevalence of severe depressive symptoms (CES-D≥23) was 44%. 25% of participants had mild to moderate depressive symptoms (16≤CES-D<23), and 31% experienced no depressive symptoms (CES-D<16). Not being married, self-rated poor health, greater frequency of injection drug use, history of overdose, no alcohol use, and daily cigarette smoking were positively associated with severe depressive symptoms in unadjusted models and remained predictive in a multivariable model. The strongest predictors of depressive symptoms were self-reported poor health (POR = 2.94, 95% CI: 1.82, 4.76), no current alcohol use (POR = 2.35, 95% CI: 1.47, 3.77), and not currently married or cohabitating (POR = 2.21, 95% CI = 1.40, 3.47). Severe depressive symptoms were common among HIV-positive PWID in Thai Nguyen and were strongly associated with demographic, clinical, and psychosocial factors. Interventions that promote social support from family and reduce drug dependence may particularly benefit PWID experiencing severe depressive symptoms. Greater recognition and treatment of depressive symptoms has the potential to enhance quality of life and improve HIV clinical outcomes for PWID.

PREFACE: 1st International Workshop on Theoretical and Computational Physics: Condensed Matter, Soft Matter and Materials Physics & 38th National Conference on Theoretical Physics

Science.gov (United States)

2014-09-01

This volume contains selected papers presented at the 38th National Conference on Theoretical Physics (NCTP-38) and the 1st International Workshop on Theoretical and Computational Physics: Condensed Matter, Soft Matter and Materials Physics (IWTCP-1). Both the conference and the workshop were held from 29 July to 1 August 2013 in Pullman hotel, Da Nang, Vietnam. The IWTCP-1 was a new activity of the Vietnamese Theoretical Physics Society (VTPS) organized in association with the 38th National Conference on Theoretical Physics (NCTP-38), the most well-known annual scientific forum dedicated to the dissemination of the latest development in the field of theoretical physics within the country. The IWTCP-1 was also an External Activity of the Asia Pacific Center for Theoretical Physics (APCTP). The overriding goal of the IWTCP is to provide an international forum for scientists and engineers from academia to share ideas, problems and solution relating to the recent advances in theoretical physics as well as in computational physics. The main IWTCP motivation is to foster scientific exchanges between the Vietnamese theoretical and computational physics community and world-wide scientists as well as to promote high-standard level of research and education activities for young physicists in the country. About 110 participants coming from 10 countries participated in the conference and the workshop. 4 invited talks, 18 oral contributions and 46 posters were presented at the conference. In the workshop we had one keynote lecture and 9 invited talks presented by international experts in the fields of theoretical and computational physics, together with 14 oral and 33 poster contributions. The proceedings were edited by Nguyen Tri Lan, Trinh Xuan Hoang, and Nguyen Ai Viet. We would like to thank all invited speakers, participants and sponsors for making the conference and the workshop successful. Nguyen Ai Viet Chair of NCTP-38 and IWTCP-1

Growth, Characterization and Device Development in Monocrystalline Diamond Films

Science.gov (United States)

1991-09-30

the conduction mechanisms. Research supported by SD10/1IST & managed by Wright Laboratory 1. J.A. Herb , C. Bailey, K.V. Ravi, and P.A. Dennig, "The...1982 from [951 K. L Moazed, R. Nguyen, and J. R. Zeidler, "Ohmic contacts National Taiwan University, Taiwan , ROC. to semiconducting diamond," IEEE

78 FR 12763 - Fecal Microbiota for Transplantation; Public Workshop

Science.gov (United States)

2013-02-25

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-N-0001... accommodations due to a disability, please contact Chris Nguyen (see Contact Person) at least 7 days in advance... phases of the investigation, to assure the safety and rights of subjects, and, in Phases 2 and 3, to help...

Role of Setbp1 in Myeloid Leukemia Development

Science.gov (United States)

2014-09-05

Nhu Nguyen1,Vijay Negi1, Kevin Oakley1, Bartlomiej Przychodzen2, Jaroslaw P. Maciejewski2,3, and Yang Du1,3 1Department of Pediatrics, Uniformed...Sozer S, Ashton J, Rossi RM, et al. 2007. Leukemia stem cells in a genetically defined murine model of blast-crisis CML. Blood 110:2578- 85 86

Preferences for Key Ethical Principles that Guide Business School Students

Science.gov (United States)

Guyette, Roger; Piotrowski, Chris

2010-01-01

Business ethics is presently a major component of the business school curriculum. Although there has been much attention focused on the impact of such coursework on instilling ethical decision-making (Nguyen et al., 2008), there is sparse research on how business students view the major ethical principles that serve as the foundation of business…

Hanoi and the American War: Two International Histories

Directory of Open Access Journals (Sweden)

Geoffrey C. Stewart

2014-03-01

Full Text Available Pierre Asselin, Hanoi’s Road to the Vietnam War, 1954-1965. Berkeley: University of California Press, 2013. 319 pp. $55 (cloth Lien-Hang T. Nguyen, Hanoi’s War: An International History of the War for Peace in Vietnam. Chapel Hill: The University of North Carolina Press, 2012. 444 pp. $34.95 (cloth.

Uudne lähenemine valgustite maailmas 2012. aastal / Ülle Jõks

Index Scriptorium Estoniae

Jõks, Ülle, 1966-

2012-01-01

Tendentsidest valgustimaailmas. Led tehnoloogia täiustamisest. Lähemalt firma Flos uuest kollektsioonist "Soft architecture" (disainerid Ron Gilad, Antonio Citterio. Philippe Starck, Marcel Wanders jt.)

The rhoptry proteome of Eimeria tenella sporozoites

KAUST Repository

Oakes, Richard D.; Kurian, Dominic; Bromley, Elizabeth V.; Ward, Chris; Lal, Kalpana; Blake, Damer P.; Reid, Adam James; Pain, Arnab; Sinden, Robert E.; Wastling, Jonathan M.; Tomley, F. M. M Fiona

2013-01-01

Proteins derived from the rhoptry secretory organelles are crucial for the invasion and survival of apicomplexan parasites within host cells. The rhoptries are club-shaped organelles that contain two distinct subpopulations of proteins that localise to separate compartments of the organelle. Proteins from the neck region (rhoptry neck proteins, RON) are secreted early in invasion and a subset of these is critical for the formation and function of the moving junction between parasite and host membranes. Proteins from the bulb compartment (rhoptry protein, ROP) are released later, into the nascent parasitophorous vacuole where they have a role in modifying the vacuolar environment, and into the host cell where they act as key determinants of virulence through their ability to interact with host cell signalling pathways, causing an array of downstream effects. In this paper we present the results of an extensive proteomics analysis of the rhoptry organelles from the coccidian parasite, Eimeria tenella, which is a highly pathogenic parasite of the domestic chicken causing severe caecal coccidiosis. Several different classes of rhoptry protein have been identified. First are the RON proteins that have varying degrees of similarity to proteins of Toxoplasma gondii and Neospora caninum. For some RON families, E. tenella expresses more than one gene product and many of the individual RON proteins are differentially expressed between the sporozoite and merozoite developmental stages. The E. tenella sporozoite rhoptry expresses only a limited repertoire of proteins with homology to known ROP proteins from other coccidia, including just two secreted ROP kinases, both of which appear to be equipped for catalytic activity. Finally, a large number of hitherto undescribed proteins that map to the sporozoite rhoptry are identified, many of which have orthologous proteins encoded within the genomes of T. gondii and N. caninum. © 2012 .

The rhoptry proteome of Eimeria tenella sporozoites

KAUST Repository

Oakes, Richard D.

2013-02-01

Proteins derived from the rhoptry secretory organelles are crucial for the invasion and survival of apicomplexan parasites within host cells. The rhoptries are club-shaped organelles that contain two distinct subpopulations of proteins that localise to separate compartments of the organelle. Proteins from the neck region (rhoptry neck proteins, RON) are secreted early in invasion and a subset of these is critical for the formation and function of the moving junction between parasite and host membranes. Proteins from the bulb compartment (rhoptry protein, ROP) are released later, into the nascent parasitophorous vacuole where they have a role in modifying the vacuolar environment, and into the host cell where they act as key determinants of virulence through their ability to interact with host cell signalling pathways, causing an array of downstream effects. In this paper we present the results of an extensive proteomics analysis of the rhoptry organelles from the coccidian parasite, Eimeria tenella, which is a highly pathogenic parasite of the domestic chicken causing severe caecal coccidiosis. Several different classes of rhoptry protein have been identified. First are the RON proteins that have varying degrees of similarity to proteins of Toxoplasma gondii and Neospora caninum. For some RON families, E. tenella expresses more than one gene product and many of the individual RON proteins are differentially expressed between the sporozoite and merozoite developmental stages. The E. tenella sporozoite rhoptry expresses only a limited repertoire of proteins with homology to known ROP proteins from other coccidia, including just two secreted ROP kinases, both of which appear to be equipped for catalytic activity. Finally, a large number of hitherto undescribed proteins that map to the sporozoite rhoptry are identified, many of which have orthologous proteins encoded within the genomes of T. gondii and N. caninum. © 2012 .

L Ron Hubbard's science fiction quest against psychiatry.

Science.gov (United States)

Hirshbein, Laura

2016-12-01

Layfayette Ronald Hubbard (1911-1986) was a colourful and prolific American writer of science fiction in the 1930s and 1940s. During the time between his two decades of productivity and his return to science fiction in 1980, Hubbard founded the Church of Scientology. In addition to its controversial status as a religion and its troubling pattern of intimidation and litigation directed towards its foes, Scientology is well known as an organised opponent to psychiatry. This paper looks at Hubbard's science fiction work to help understand the evolution of Scientology's antipsychiatry stance, as well as the alternative to psychiatry offered by Hubbard. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Kirjanik sõdib ühe raamatu avaldamise poolt ja teise vastu / Kaarel Kressa

Index Scriptorium Estoniae

Kressa, Kaarel, 1983-

2008-01-01

Ameerika kirjastuse Random House otsusest loobuda Sherry Jonesi romaani "Jewel of Medina" avaldamisest ning Salman Rushdie kohtuasjast teda solvanud Ron Evansi raamatu "On Her Majesty's service" vastu

A new graduate education program in radiation therapy

International Nuclear Information System (INIS)

Beldham-Collins, Rachael; Milinkovic, Danielle

2009-01-01

Purpose: The evaluation of the Radiation Oncology Network's (RON) in house professional development year (PDY) support program was implemented to determine the appropriate teaching, learning and transfer of learning strategies that assist the newly practicing radiation therapists' transition into the busy working environment. As the AIR program saw little clinical support offered to participating new graduates and thus a need for further educational support was felt. The RON support program was initially introduced as the clinical education support component of the NSW PDY program that was introduced in 1995 by the Australian Institute of Radiography. Method: Following the facilitation of the RON PDY program over a twelve month period, qualitative feedback was obtained using a focus group consisting of new graduates from the program. Two moderators facilitated the focus group: one moderator facilitated the discussion while the second moderator transcribed it. The graduate practitioners were asked a number of questions related to the teaching and learning strategies employed by the program as well as the structure of the program. Results/discussion: The responses were analysed into the following themes: teaching and learning strategies, transfer of learning, facilitation and future learning needs. Overall the graduate practitioners found the program nurtured their skill, knowledge and attitudes appropriately at such a critical stage in their career

The academic trend of Oriental Medicine during the Japanese colonial period as observed through the publication of medical books

Directory of Open Access Journals (Sweden)

KIM Nam-il

2006-06-01

Full Text Available This thesis examines the academical trend of Oriental Medicine in the Japanese colonial period observed through medical books published during the Japanese colonial period.This is a period in which Western Medicine was introduced,and due to the lean-to-one-side policy by the Japanese, Western Medicine became the mainstream medical science while Oriental Medicine was pushed to the outskirts.Even after all this,the academic activity was flourishing during this period compared to any other periods. This article is divided into various chapters each with its own theme in order to understand the academic trend of Oriental Medicine during the Japanese colonial period.Focusing on the publication of medical books, this article is divided and observed according to various themes such as the study of Dong-Eui-Bo-Gam(東醫寶鑑,the study of Bang-Yak-Hap- Pyeun(方藥合編,the study of Sang-Han-Ron(傷寒論,the study of Sa-sang (四象constitutional medicine,the study of Eui-Hak-Ip-Mun (醫學入門,the study about Bu-Yang-Ron(扶陽論,On-Bo-Ron(溫補論,and pediatrics, compromise between Western and Oriental Medicine,the study of experience medicine,the study of acupuncture and moxibustion,and etc.

Relating the octane numbers of fuels to ignition delay times measured in an ignition quality tester (IQT)

KAUST Repository

Naser, Nimal

2016-09-21

A methodology for estimating the octane index (OI), the research octane number (RON) and the motor octane number (MON) using ignition delay times from a constant volume combustion chamber with liquid fuel injection is proposed by adopting an ignition quality tester. A baseline data of ignition delay times were determined using an ignition quality tester at a charge pressure of 21.3 bar between 770 and 850 K and an equivalence ratio of 0.7 for various primary reference fuels (PRFs, mixtures of isooctane and n-heptane). Our methodology was developed using ignition delay times for toluene reference fuels (mixtures of toluene and n-heptane). A correlation between the OI and the ignition delay time at the initial charge temperature enabled the OI of non-PRFs to be predicted at specified temperatures. The methodology was validated using ignition delay times for toluene primary reference fuels (ternary mixtures of toluene, iso-octane, and n-heptane), fuels for advanced combustion engines (FACE) gasolines, and certification gasolines. Using this methodology, the RON, the MON, and the octane sensitivity were estimated in agreement with values obtained from standard test methods. A correlation between derived cetane number and RON is also provided. (C) 2016 Elsevier Ltd. All rights reserved.

A new formulation of physical surrogates of FACE A gasoline fuel based on heating and evaporation characteristics

KAUST Repository

Elwardani, Ahmed Elsaid; Sazhin, S.S.; Im, Hong G.

2016-01-01

The US Department of Energy has formulated various sets of gasoline fuels, called fuels for advanced combustion engines (FACE), which are consistent in composition and properties. The analysis of heating and evaporation of FACE A gasoline fuel (paraffin-rich) is studied by replacing the 66 components with 19 components to represent this fuel. The reduction in the number of components is based on merging components from the same chemical groups and having the same chemical formula, which have very close thermophysical properties; the components with the highest initial compositions are chosen to be the representative components. Modelling of heating and evaporation of FACE A gasoline fuel and various surrogates is carried out based on the effective thermal conductivity/effective diffusivity model (ETC/ED). The model takes into account the effect of finite liquid thermal conductivity, finite liquid mass diffusivity and recirculation inside the droplets due to their non-zero velocities relative to the ambient air. Four surrogates of FACE A found in the literature are used in the analysis. These surrogates include the five component surrogate chosen for its ability to match the ignition delay time of the FACE A gasoline fuel (Surr1), the primary reference fuel surrogate (PRF84) that matches the research octane number (RON) of FACE A, the one that matches hydrogen-to-carbon ratio (H/C), RON, density and distillation curve with FACE A (Surr2), and the one that matches the RON based on mole fraction linear blending (Surr3). It is shown that these surrogates cannot predict adequately the time evolution of surface temperatures and radii of FACE A droplets. New 'physical' surrogates with 8, 7 and 6 components (Surr4, Surr5, and Surr6) are introduced to match the evaporation characteristics of FACE A. It is found that Surr5 (7 components surrogate) can predict droplet lifetime and time evolution of surface temperature of a FACE A droplet with errors of up to 5% and 0

A new formulation of physical surrogates of FACE A gasoline fuel based on heating and evaporation characteristics

KAUST Repository

Elwardani, Ahmed Elsaid

2016-02-19

The US Department of Energy has formulated various sets of gasoline fuels, called fuels for advanced combustion engines (FACE), which are consistent in composition and properties. The analysis of heating and evaporation of FACE A gasoline fuel (paraffin-rich) is studied by replacing the 66 components with 19 components to represent this fuel. The reduction in the number of components is based on merging components from the same chemical groups and having the same chemical formula, which have very close thermophysical properties; the components with the highest initial compositions are chosen to be the representative components. Modelling of heating and evaporation of FACE A gasoline fuel and various surrogates is carried out based on the effective thermal conductivity/effective diffusivity model (ETC/ED). The model takes into account the effect of finite liquid thermal conductivity, finite liquid mass diffusivity and recirculation inside the droplets due to their non-zero velocities relative to the ambient air. Four surrogates of FACE A found in the literature are used in the analysis. These surrogates include the five component surrogate chosen for its ability to match the ignition delay time of the FACE A gasoline fuel (Surr1), the primary reference fuel surrogate (PRF84) that matches the research octane number (RON) of FACE A, the one that matches hydrogen-to-carbon ratio (H/C), RON, density and distillation curve with FACE A (Surr2), and the one that matches the RON based on mole fraction linear blending (Surr3). It is shown that these surrogates cannot predict adequately the time evolution of surface temperatures and radii of FACE A droplets. New \\'physical\\' surrogates with 8, 7 and 6 components (Surr4, Surr5, and Surr6) are introduced to match the evaporation characteristics of FACE A. It is found that Surr5 (7 components surrogate) can predict droplet lifetime and time evolution of surface temperature of a FACE A droplet with errors of up to 5% and 0

Observations and High-Resolution Numerical Simulations of a Non-Developing Tropical Disturbance in the Western North Pacific

Science.gov (United States)

2013-09-01

frozen condensate melts and evaporates as it falls, which tends to increase low-level moisture . Nguyen and Molinari (2012) examined the rapid...spherical particles of constant density, exponential size distributions, and constant intercept parameters. A comparison of ELDORA and model-derived...mid-troposphere, air cools, and a deep layer of subsidence forms. At the same time, condensational warming within the stratiform cloud deck

Neuro Inspired Adaptive Perception and Control for Agile Mobility of Autonomous Vehicles in Uncertain and Hostile Environments

Science.gov (United States)

2017-02-08

Strategy for Ambush Avoidance, AAAI Conference on Artificial Intelligence . 28-JAN-15, Austin, TX. : , S.-Z. Yong, B. Paden, and E. Frazzoli...Object-based Bayesian Framework for Top-down Visual Attention, Twenty-Sixth AAAI Conference on Artificial Intelligence . , . : , Kyel Ok, Duy-Nguyen...Conference on Intelligent Robots and Systems. 28-SEP-15, . : , Jiaping Zhao, Christian Siagian, Laurent Itti. Fixation Bank : Learning to Reweight Fixation

Mitchell Receives 2013 Ronald Greeley Early Career Award in Planetary Science: Citation

Science.gov (United States)

McKinnon, William B.

2014-07-01

The Greeley Early Career Award is named for pioneering planetary scientist Ronald Greeley. Ron was involved in nearly every major planetary mission from the 1970s until his death and was extraordinarily active in service to the planetary science community. Ron's greatest legacies, however, are those he mentored through the decades, and it is young scientists whose work and promise we seek to recognize. This year's Greeley award winner is Jonathan L. Mitchell, an assistant professor at the University of California, Los Angeles (UCLA). Jonathan received his Ph.D. from the University of Chicago, and after a postdoc at the Institute for Advanced Studies in Princeton, he joined the UCLA faculty, where he holds a joint appointment in Earth and space sciences and in atmospheric sciences.

78 FR 26255 - Approval and Promulgation of Air Quality Implementation Plans; Texas; Approval of Texas Low...

Science.gov (United States)

2013-05-06

... recordkeeping requirements, Sulfur oxides, Volatile organic compounds. Dated: April 5, 2013. Ron Curry, Regional... and is required for use by on-highway vehicles and non-road equipment (including marine vessels) in...

78 FR 17409 - Agency Forms Undergoing Paperwork Reduction Act Review

Science.gov (United States)

2013-03-21

... the social ecological model (SEM) that coordinate and align with existing prevention strategies at the... reporting. Dated: March 15, 2013. Ron A. Otten, Director, Office of Scientific Integrity (OSI), Office of...

Dragnet: A Case Study of the CLEAR System

National Research Council Canada - National Science Library

Musa, Samuel; Keegan, Matt; Kyser, Giles

2007-01-01

...). The quickest way to describe CLEAR is to mention a quote from Ron Huberman, assistant deputy superintendent, Office of Information and Strategic Services at CPD "CLEAR automates everything we do in...

Mediation Analyses in the Real World

DEFF Research Database (Denmark)

Lange, Theis; Starkopf, Liis

2016-01-01

The paper by Nguyen et al.1 published in this issue of Epidemiology presents a comparison of the recently suggested inverse odds ratio approach for addressing mediation and a more conventional Baron and Kenny-inspired method. Interestingly, the comparison is not done through a discussion of restr......The paper by Nguyen et al.1 published in this issue of Epidemiology presents a comparison of the recently suggested inverse odds ratio approach for addressing mediation and a more conventional Baron and Kenny-inspired method. Interestingly, the comparison is not done through a discussion...... it simultaneously ensures that the comparison is based on properties, which matter in actual applications, and makes the comparison accessible for a broader audience. In a wider context, the choice to stay close to real-life problems mirrors a general trend within the literature on mediation analysis namely to put...... applications using the inverse odds ration approach, as it simply has not had enough time to move from theoretical concept to published applied paper, we do expect to be able to judge the willingness of authors and journals to employ the causal inference-based approach to mediation analyses. Our hope...

Impact of Triticum mosaic virus infection on hard winter wheat milling and bread baking quality.

Science.gov (United States)

Miller, Rebecca A; Martin, T Joe; Seifers, Dallas L

2012-03-15

Triticum mosaic virus (TriMV) is a newly discovered wheat virus. Information regarding the effect of wheat viruses on milling and baking quality is limited. The objective of this study was to determine the impact of TriMV infection on the kernel characteristics, milling yield and bread baking quality of wheat. Commercial hard winter varieties evaluated included RonL, Danby and Jagalene. The TriMV resistance of RonL is low, while that of Danby and Jagalene is unknown. KS96HW10-3, a germplasm with high TriMV resistance, was included as a control. Plots of each variety were inoculated with TriMV at the two- to three-leaf stage. Trials were conducted at two locations in two crop years. TriMV infection had no effect on the kernel characteristics, flour yield or baking properties of KS96HW10-3. The effect of TriMV on the kernel characteristics of RonL, Danby and Jagalene was not consistent between crop years and presumably an environmental effect. The flour milling and bread baking properties of these three varieties were not significantly affected by TriMV infection. TriMV infection of wheat plants did not affect harvested wheat kernel characteristics, flour milling properties or white pan bread baking quality. Copyright © 2011 Society of Chemical Industry.

Oxidative and nitrosative stress in trichloroethene-mediated autoimmune response

International Nuclear Information System (INIS)

Wang Gangduo; Cai Ping; Ansari, G.A.S.; Khan, M. Firoze

2007-01-01

Reactive oxygen and nitrogen species (RONS) are implicated in the pathogenesis of several autoimmune diseases. Also, increased lipid peroxidation and protein nitration are reported in systemic autoimmune diseases. Lipid peroxidation-derived aldehydes (LPDAs) such as malondialdehyde (MDA) and 4-hydroxynonenal (HNE) are highly reactive and bind proteins covalently, but their potential to elicit an autoimmune response and contribution to disease pathogenesis remain unclear. Similarly, nitration of protein could also contribute to disease pathogenesis. To assess the status of lipid peroxidation and/or RONS, autoimmune-prone female MRL+/+ mice (5-week old) were treated with trichloroethene (TCE), an environmental contaminant known to induce autoimmune response, for 48 weeks (0.5 mg/ml via drinking water), and formation of antibodies to LPDA-protein adducts was followed in the sera of control and TCE-treated mice. TCE treatment led to greater formation of both anti-MDA- and -HNE-protein adduct antibodies and higher serum iNOS and nitrotyrosine levels. The increase in TCE-induced oxidative stress was associated with increases in anti-nuclear-, anti-ssDNA- and anti-dsDNA-antibodies. These findings suggest that TCE exposure not only leads to oxidative/nitrosative stress, but is also associated with induction/exacerbation of autoimmune response in MRL+/+ mice. Further interventional studies are needed to establish a causal role of RONS in TCE-mediated autoimmunity

A new graduate education program in radiation therapy

Energy Technology Data Exchange (ETDEWEB)

Beldham-Collins, Rachael [Radiation Oncology Network, Department of Radiation Oncology, Westmead Hospital, PO Box 533, Wentworthville NSW 2145 (Australia); School of Medical Radiation Sciences, Faculty of Health Sciences, University of Sydney, PO Box 170, Lidcombe, NSW 1825 (Australia); Milinkovic, Danielle [School of Medical Radiation Sciences, Faculty of Health Sciences, University of Sydney, PO Box 170, Lidcombe, NSW 1825 (Australia)], E-mail: d.milinkovic@fhs.usyd.edu.au

2009-02-15

Purpose: The evaluation of the Radiation Oncology Network's (RON) in house professional development year (PDY) support program was implemented to determine the appropriate teaching, learning and transfer of learning strategies that assist the newly practicing radiation therapists' transition into the busy working environment. As the AIR program saw little clinical support offered to participating new graduates and thus a need for further educational support was felt. The RON support program was initially introduced as the clinical education support component of the NSW PDY program that was introduced in 1995 by the Australian Institute of Radiography. Method: Following the facilitation of the RON PDY program over a twelve month period, qualitative feedback was obtained using a focus group consisting of new graduates from the program. Two moderators facilitated the focus group: one moderator facilitated the discussion while the second moderator transcribed it. The graduate practitioners were asked a number of questions related to the teaching and learning strategies employed by the program as well as the structure of the program. Results/discussion: The responses were analysed into the following themes: teaching and learning strategies, transfer of learning, facilitation and future learning needs. Overall the graduate practitioners found the program nurtured their skill, knowledge and attitudes appropriately at such a critical stage in their career.

75 FR 77652 - Notice of Intent to Prepare a Resource Management Plan for the Battle Mountain District and...

Science.gov (United States)

2010-12-13

... agencies where appropriate. (7) The planning process will use and observe principles of multiple use and..., sociology and economics, and Geographic Information Systems. Authority: 40 CFR 1501.7, 43 CFR 1610.2. Ron...

Politics Does Matter: The Nigerian State and Oil (Resource) Curse

African Journals Online (AJOL)

chifaou.amzat

Conventional explanations of the resource curse, or the paradox of abundance, correlate ..... Middle Class In Colonial India, Oxford University Press, A Book Review ... Department of Government, Harvard University, Cambridge. Ron, J., 2005 ...

77 FR 50696 - Proposed Data Collections Submitted for Public Comment and Recommendations

Science.gov (United States)

2012-08-22

... opportunity to evaluate the efficacy of this new public health model. CDC plans to conduct an impact... 2,393 Dated: August 16, 2012. Ron A. Otten, Director, Office of Scientific Integrity (OSI), Office...

Cellular computing

National Research Council Canada - National Science Library

Amos, Martyn

2004-01-01

... 120 Ron Weiss, Thomas F. Knight Jr., and Gerald Sussman 8 The Biology of Integration of Cells into Microscale and Nanoscale Systems 148 Michael L. Simpson, Timothy E. McKnight, Michael A. Guillor...

Translations on Environmental Quality No. 139

Science.gov (United States)

1977-06-20

personal names, title and series) are available through Bell & Howell, Old Mansfield Road, Wooster, Ohio, 44691. Correspondence pertaining to matters...Vietnamese 16 Mar 77 p 9 [Article by Nguyen Dang Due, MS in Medical Science, the Institute of Hygine and Epidemiology: "Protecting the Environment...concern among persons engaged in protecting the environment. Water pollution and air pollution are two major problems to which particular attention is

BioProgrammable One, Two, and Three Dimensional Materials

Science.gov (United States)

2017-01-18

with electron beam lithography to simultaneously control material structure at the nano- and macroscopic length scales. The Nguyen group has... inversely proportional to the d-orbital occupancy.20 This means that the higher the intensity of the white line peak, the greater the positive charge that...the chiroptical response of the gold nanoparticle helices should be inversely proportional to helix pitch, strategies were developed to

Fine structure and energy spectrum of exciton in direct band gap cubic semiconductors with degenerate valence bands

International Nuclear Information System (INIS)

Nguyen Toan Thang; Nguyen Ai Viet; Nguyen Que Huong

1987-06-01

The influence of the cubic structure on the energy spectrum of direct exciton is investigated, using the new method suggested by Nguyen Van Hieu and co-workers. Explicit expressions of the exciton energy levels 1S, 2S and 2P are derived. A comparison with the experiments and the other theory is done for ZnSe. (author). 10 refs, 1 fig., 2 tabs

Near East/South Asia Report, No. 2754

Science.gov (United States)

1983-05-17

steady, arbitrary introduction 67 of Israeli law, Israeli taxation and Israeli population to the occupied territories merely supports the fact...During the recent non-aligned summit in Delhi, the Vietnamese Foreign Minister, Mr. Nguyen Co Thach, had a private meeting with his Malaysian ...force of circumstances, to extend support to the communist underground in Malaysia to safeguard its own tactical position. Though the Malaysian

Bioblendstocks that Enable High Efficiency Engine Designs

Energy Technology Data Exchange (ETDEWEB)

McCormick, Robert L.; Fioroni, Gina M.; Ratcliff, Matthew A.; Zigler, Bradley T.; Farrell, John

2016-11-03

The past decade has seen a high level of innovation in production of biofuels from sugar, lipid, and lignocellulose feedstocks. As discussed in several talks at this workshop, ethanol blends in the E25 to E50 range could enable more highly efficient spark-ignited (SI) engines. This is because of their knock resistance properties that include not only high research octane number (RON), but also charge cooling from high heat of vaporization, and high flame speed. Emerging alcohol fuels such as isobutanol or mixed alcohols have desirable properties such as reduced gasoline blend vapor pressure, but also have lower RON than ethanol. These fuels may be able to achieve the same knock resistance benefits, but likely will require higher blend levels or higher RON hydrocarbon blendstocks. A group of very high RON (>150) oxygenates such as dimethyl furan, methyl anisole, and related compounds are also produced from biomass. While providing no increase in charge cooling, their very high octane numbers may provide adequate knock resistance for future highly efficient SI engines. Given this range of options for highly knock resistant fuels there appears to be a critical need for a fuel knock resistance metric that includes effects of octane number, heat of vaporization, and potentially flame speed. Emerging diesel fuels include highly branched long-chain alkanes from hydroprocessing of fats and oils, as well as sugar-derived terpenoids. These have relatively high cetane number (CN), which may have some benefits in designing more efficient CI engines. Fast pyrolysis of biomass can produce diesel boiling range streams that are high in aromatic, oxygen and acid contents. Hydroprocessing can be applied to remove oxygen and consequently reduce acidity, however there are strong economic incentives to leave up to 2 wt% oxygen in the product. This oxygen will primarily be present as low CN alkyl phenols and aryl ethers. While these have high heating value, their presence in diesel fuel

"'The Natural World Is the Most Universal of Languages'

DEFF Research Database (Denmark)

Bjerre, Thomas Ærvold

2007-01-01

Interview med den amerikanske forfatter Ron Rash. Rash taler bl.a. om de forskellige temaer i sine værker, om forholdet til naturen, og regionale fordomme i USA og om sine skrivevaner. Udgivelsesdato: Winter...

Tehnomeistrid / Eva Nooni

Index Scriptorium Estoniae

Nooni, Eva

2007-01-01

Tehnomeistrite liikumisest Londonis (Troika, Random International, Crispin Jones, Nicolas Roope, Philip Worthington, Tony Dunne, Ron Arad), Leipzigis (Spherical Robots) ja Kölnis (Fur). Disainiliikumist iseloomustavad kõrgtehnoloogia ja veidrad ainueksemplarid, võideldakse maitsetu kujunduse vastu

Plaadid / Priit Juurmann

Index Scriptorium Estoniae

Juurmann, Priit

2006-01-01

Uutest heliplaatidest Alexkid "Caracol", Bob Dylan "Modern Times", Justin Timberlake "Future Sex", Ilves, Pulk ja Rahman "Murõt ei olõ", Audioslave "Revelations", Bill Frisell "Bill Frisell, Ron Carter, Paul Motian", Julie & Khari "Moon Bossa"

Aleksi II kritikujet "Kod da Vintshi"

Index Scriptorium Estoniae

2006-01-01

Dan Browni samanimelise romaani järgi valminud põnevusfilm "Da Vinci kood" : režissöör Ron Howard : Ameerika Ühendriigid 2006. Venemaa patriarh Aleksius II nimetas filmi linastamist lugupidamatuseks moraalinormide vastu

12 kuulsat tugitooli / Kersti Pikk

Index Scriptorium Estoniae

Pikk, Kersti

2012-01-01

Eileen Gray, Alvar Aalto, Charles ja Ray Eames'i, Arne Jacobseni, Yrjö Kukkapuro, Alessandro Mendini, Ron Arad'i, Marcel Wanders'i, Fernando ja Humberto Campana, Antonio Citterio, Vincent van Duysen'i, Paola Navone disainitud tugitoolid

6 Common Cancers - Colorectal Cancer

Science.gov (United States)

... Home Current Issue Past Issues 6 Common Cancers - Colorectal Cancer Past Issues / Spring 2007 Table of Contents For ... of colon cancer. Photo: AP Photo/Ron Edmonds Colorectal Cancer Cancer of the colon (large intestine) or rectum ( ...

Combustion Stratification for Naphtha from CI Combustion to PPC

KAUST Repository

Vallinayagam, R.; Vedharaj, S.; An, Yanzhao; Dawood, Alaaeldin; Izadi Najafabadi, Mohammad; Somers, Bart; Johansson, Bengt

2017-01-01

This study demonstrates the combustion stratification from conventional compression ignition (CI) combustion to partially premixed combustion (PPC). Experiments are performed in an optical CI engine at a speed of 1200 rpm for diesel and naphtha (RON

Autoignition characteristics of oxygenated gasolines

KAUST Repository

Lee, Changyoul; Ahmed, Ahfaz; Nasir, Ehson Fawad; Badra, Jihad; Kalghatgi, Gautam; Sarathy, Mani; Curran, Henry; Farooq, Aamir

2017-01-01

Gasoline anti-knock quality, defined by the research and motor octane numbers (RON and MON), is important for increasing spark ignition (SI) engine efficiency. Gasoline knock resistance can be increased using a number of blending components

When stars meet particles

CERN Multimedia

2009-01-01

On 12 February CERN hosted a visit from actors Tom Hanks and Ayelet Zurer and director Ron Howard as they unveiled some exclusive footage from their new film adaptation of Dan Brown’s novel Angels and Demons.

How infrastructure delivery can find its way again

CSIR Research Space (South Africa)

Watermeyer, R

2013-03-01

Full Text Available (3), pp 17-29 How infrastructure delivery can find its way again Ron Watermeyer (Soderlund & Schutte), Kevin Wall (CSIR), Graham Pirie (Consulting Engineers South Africa) Abstract The National Planning Commission, chaired by the Minister...

United States-Vietnam Relations 1945-1967 (Book 1 of 12)

Science.gov (United States)

1971-01-01

Virginia W. C. (DAN) DANIEL, Virginia G. V. (SONNY) MONTGOMERY. Mississippi MICHAEL J. HARRINGTON, Massachusetts HAROLD RUNNELS, New Mexico LES ASPIN...Committee established and who chose it? Will Front policy be followed and will there be communication with the Front? Adn since this assembly is...Went to Singapore, arrested again and sent back to Hong Kong. Admitted to hospital for . tuberculosis . 1933 Nguyen Ai Quoc reported dead in Hong

Identifying Barriers to Knowledge Management in the US Military

Science.gov (United States)

2002-12-16

Knowledge Age In his 1980s best-seller, Megatrends , John Naisbitt proposed that our industrial society had transformed itself into an information society...considered to be representations of the world that consist of objects and events, and the challenge of a cognitive system, computational or biological ...Naisbitt, J. (1984). Megatrends . New York: Warner Books, Inc. Nguyen, B. (2000). Building a Knowledge-Centric United States Air Force. 1250 AF

Serious Game and Virtual World Training: Instrumentation and Assessment

Science.gov (United States)

2012-12-10

concepts, built upon those learned previously (Nguyen, 2010). Each exhibit on the trail is accompanied by an interactive assessment, taking the form of a...discussed as a current state technology in section 3.3, requires a great deal of technological and pedagogical development. The technology to create...assessment can be implemented. In addition to the technology, pedagogical principles must be understood as to what makes for a successful assessment and

Development of a Computational Assay for the Estrogen Receptor

Science.gov (United States)

2006-07-01

Research in Undergraduate Computational Chemistry across New York and New England" at the Executive Summit, Delivering Technology Leadership for Life...Sciences: Research Advances for Drug Discovery and Bioterrorism. A Life Sciences Executive Summit co-sponsored by SGI, the Delaware Biotechnology...Bharath, J.; Jain, S.; Pham, H. B.; Boonyasiriwat, C.; Nguyen, N.; Andersen, E.; Kim, Y.; Choc , S.; Choi, J.; Cheatham, T. E.; Facelli, J. C. J. Chemical

Managing an outpatient parenteral antibiotic therapy team: challenges and solutions

OpenAIRE

Nguyen, Hien; Halilovic,Jenana; Christensen,Cinda

2014-01-01

Jenana Halilovic,1 Cinda L Christensen,2 Hien H Nguyen31University of the Pacific Thomas J Long School of Pharmacy, Stockton, CA, USA; 2Department of Pharmaceutical Services, University of California, Davis Health System, Sacramento, CA, USA; 3Division of Infectious Diseases, Section of Hospital Medicine, University of California, Davis Health System, Sacramento, CA, USAAbstract: Outpatient parenteral antimicrobial therapy (OPAT) programs should strive to deliver safe, cost effective, and hig...

Evaluation of Data Processing Techniques for Unobtrusive Gait Authentication

Science.gov (United States)

2014-03-01

INTENTIONALLY LEFT BLANK xiii LIST OF ACRONYMS AND ABBREVIATIONS API application programming interface BFCC bark-frequency cepstral coefficient...Numpy [39] libraries for the following manipulations. 1. Interpolation Due to a limitation in the Android API , the only time the data is pulled from the...Postgraduate School, Monterey, CA, 2014. 67 [49] V. Nguyen, “Continuous authentication of a smartphone user using RSSI-based geolocation ,” M.S. thesis

Dynamics and Control of Non-Smooth Systems with Applications to Supercavitating Vehicles

Science.gov (United States)

2011-01-01

ABSTRACT Title of dissertation: Dynamics and Control of Non-Smooth Systems with Applications to Supercavitating Vehicles Vincent Nguyen, Doctor of...relates to the dynamics of non-smooth vehicle systems, and in particular, supercavitating vehicles. These high-speed under- water vehicles are...Applications to Supercavitating Vehicles 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK

Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney.

Science.gov (United States)

Ebrahimkhani, Mohammad R; Daneshmand, Ali; Mazumder, Aprotim; Allocca, Mariacarmela; Calvo, Jennifer A; Abolhassani, Nona; Jhun, Iny; Muthupalani, Sureshkumar; Ayata, Cenk; Samson, Leona D

2014-11-11

Inflammation is accompanied by the release of highly reactive oxygen and nitrogen species (RONS) that damage DNA, among other cellular molecules. Base excision repair (BER) is initiated by DNA glycosylases and is crucial in repairing RONS-induced DNA damage; the alkyladenine DNA glycosylase (Aag/Mpg) excises several DNA base lesions induced by the inflammation-associated RONS release that accompanies ischemia reperfusion (I/R). Using mouse I/R models we demonstrate that Aag(-/-) mice are significantly protected against, rather than sensitized to, I/R injury, and that such protection is observed across three different organs. Following I/R in liver, kidney, and brain, Aag(-/-) mice display decreased hepatocyte death, cerebral infarction, and renal injury relative to wild-type. We infer that in wild-type mice, Aag excises damaged DNA bases to generate potentially toxic abasic sites that in turn generate highly toxic DNA strand breaks that trigger poly(ADP-ribose) polymerase (Parp) hyperactivation, cellular bioenergetics failure, and necrosis; indeed, steady-state levels of abasic sites and nuclear PAR polymers were significantly more elevated in wild-type vs. Aag(-/-) liver after I/R. This increase in PAR polymers was accompanied by depletion of intracellular NAD and ATP levels plus the translocation and extracellular release of the high-mobility group box 1 (Hmgb1) nuclear protein, activating the sterile inflammatory response. We thus demonstrate the detrimental effects of Aag-initiated BER during I/R and sterile inflammation, and present a novel target for controlling I/R-induced injury.

Blending Octane Number of Ethanol on a Volume and Molar Basis in SI and HCCI Combustion Modes

KAUST Repository

Waqas, Muhammad Umer; Morganti, Kai; Masurier, Jean-Baptiste; Johansson, Bengt

2017-01-01

The blending behavior of ethanol in five different hydrocarbon base fuels with octane numbers of approximately 70 and 84 was examined under Spark-Ignited (SI) and Homogeneous Charge Compression Ignited (HCCI) operating conditions. The Blending octane number (BON) was used to characterize the blending behavior on both a volume and molar basis. Previous studies have shown that the blending behavior of ethanol generally follows several well-established rules. In particular, non-linear blending effects are generally observed on a volume basis (i.e. BON > RON or MON of pure ethanol; 108 and 89, respectively), while linear blending effects are generally observed on a molar basis (i.e. BON = RON or MON of pure ethanol). This work firstly demonstrates that the non-linear volumetric blending effects traditionally observed under SI operating conditions are also observed under HCCI operating conditions. In keeping with previous studies, the degree of this non-linearity is shown to be a function of the base fuel composition and octane number. By contrast, the molar blending approach is shown to behave differently depending on the chosen combustion mode, with some non-linearity observed under HCCI operating conditions (i.e. BON RON or MON of pure ethanol). This suggests that the well-established blending rules for SI operating conditions may not always be relevant to other combustion modes that operate with globally lean or diluted air-fuel mixtures. This has implications for the design of future fuel specifications.

Blending Octane Number of Ethanol on a Volume and Molar Basis in SI and HCCI Combustion Modes

KAUST Repository

Waqas, Muhammad Umer

2017-10-08

The blending behavior of ethanol in five different hydrocarbon base fuels with octane numbers of approximately 70 and 84 was examined under Spark-Ignited (SI) and Homogeneous Charge Compression Ignited (HCCI) operating conditions. The Blending octane number (BON) was used to characterize the blending behavior on both a volume and molar basis. Previous studies have shown that the blending behavior of ethanol generally follows several well-established rules. In particular, non-linear blending effects are generally observed on a volume basis (i.e. BON > RON or MON of pure ethanol; 108 and 89, respectively), while linear blending effects are generally observed on a molar basis (i.e. BON = RON or MON of pure ethanol). This work firstly demonstrates that the non-linear volumetric blending effects traditionally observed under SI operating conditions are also observed under HCCI operating conditions. In keeping with previous studies, the degree of this non-linearity is shown to be a function of the base fuel composition and octane number. By contrast, the molar blending approach is shown to behave differently depending on the chosen combustion mode, with some non-linearity observed under HCCI operating conditions (i.e. BON RON or MON of pure ethanol). This suggests that the well-established blending rules for SI operating conditions may not always be relevant to other combustion modes that operate with globally lean or diluted air-fuel mixtures. This has implications for the design of future fuel specifications.

Autoignition characteristics of oxygenated gasolines

KAUST Repository

Lee, Changyoul

2017-08-14

Gasoline anti-knock quality, defined by the research and motor octane numbers (RON and MON), is important for increasing spark ignition (SI) engine efficiency. Gasoline knock resistance can be increased using a number of blending components. For over two decades, ethanol has become a popular anti-knock blending agent with gasoline fuels due to its production from bio-derived resources. This work explores the oxidation behavior of two oxygenated certification gasoline fuels and the variation of fuel reactivity with molecular composition. Ignition delay times of Haltermann (RON = 91) and Coryton (RON = 97.5) gasolines have been measured in a high-pressure shock tube and in a rapid compression machine at three pressures of 10, 20 and 40 bar, at equivalence ratios of φ = 0.45, 0.9 and 1.8, and in the temperature range of 650–1250 K. The results indicate that the effects of fuel octane number and fuel composition on ignition characteristics are strongest in the intermediate temperature (negative temperature coefficient) region. To simulate the reactivity of these gasolines, three kinds of surrogates, consisting of three, four and eight components, are proposed and compared with the gasoline ignition delay times. It is shown that more complex surrogate mixtures are needed to emulate the reactivity of gasoline with higher octane sensitivity (S = RON–MON). Detailed kinetic analyses are performed to illustrate the dependence of gasoline ignition delay times on fuel composition and, in particular, on ethanol content.

Lithium- an update on the mechanisms of action

African Journals Online (AJOL)

Adele

rons depending on the level of their activity.4 Lithium thus seems to .... clear that MARCKS is crucial in neuronal growth and brain ... lithium's activity is predominantly confined to the left fron- ... This ranges from neurotransmitter production right.

Impact of PSS and STATCOM Devices to the Dynamic Performance of a Multi-Machine Power System

Directory of Open Access Journals (Sweden)

G. Shahgholian

2017-12-01

Full Text Available This paper studies the impact of leveraging both static syn­ch­ron­ous compensator (STATCOM and power system stabilizer (PSS on multi-machine power systems. Considering a sta­ndard IEEE 9-bus test power network, classic and intelligent controllers are applied to achieve the desirable system performance. Simulated tests show the usefulness of STATCOM on network power quality in terms of voltage profile. In addition, it is shown that it can significantly improve the damping oscillations of synchronous generator under normal and abnormal network conditions. As shown, the PSS also contributes to improving the synch­ron­o­u­s generator parameters. It is also observed that using intelligent controllers with STATCOM and PSS leads to a better perfor­ma­nc­e relative to the classic controllers.

Enhanced phytoremediation of arsenic contaminated land.

Science.gov (United States)

Jankong, P; Visoottiviseth, P; Khokiattiwong, S

2007-08-01

In an attempt to clean up arsenic (As) contaminated soil, the effects of phosphorus (P) fertilizer and rhizosphere microbes on arsenic accumulation by the silverback fern, Pityrogramma calomelanos, were investigated in both greenhouse and field experiments. Field experiments were conducted in Ron Phibun District, an As-contaminated area in Thailand. Soil (136-269 microg As g(-1)) was collected there and used in the greenhouse experiment. Rhizosphere microbes (bacteria and fungi) were isolated from roots of P. calomelanos growing in Ron Phibun District. The results showed that P-fertilizer significantly increased plant biomass and As accumulation of the experimental P. calomelanos. Rhizobacteria increased significantly the biomass and As content of the test plants. Thus, P-fertilizer and rhizosphere bacteria enhanced As-phytoextraction. In contrast, rhizofungi reduced significantly As concentration in plants but increased plant biomass. Therefore, rhizosphere fungi exerted their effects on phytostabilization.

复方阿魏酸钠胺囊改善椎基动脉供血不足共济失调及行走障碍的作用%Ataxia and walking disorder improved by capsulae natrii perulatis coupositate in patients with vertebrobasilar-artery insufficiency

Institute of Scientific and Technical Information of China (English)

余桂军; 任传成; 周玲; 倪冬艳

2003-01-01

@@ INTRODUCTION Delayed nerve conduction is very common after brain injury inducedby vertebrobasilar-artery insufficiency resulting in inconsistence ofneural defect with lesion area. It is speculated that regulation neu-rons excitation and functional disorder of inhibitory neurons may beinvolved [1].

Glial Cells: The Other Cells of the Nervous System

Indian Academy of Sciences (India)

nervous system and that glial cells were a mere glue holding neurons in place, Schleich ... fact that these cells did not show any electrical activity like neurons or muscles ... membrane potential higher than that of the surrounding neu- rons.

Application of nuclear techniques for analysis of Vietnamese coal and embedding rocks

International Nuclear Information System (INIS)

Vo Dac Bang; Pham Van Duong; Nguyen Thanh Binh; Le Tien Quan; Nguyen Manh Hung; Nguyen Thi Hong; Vu Hoang Lam

1995-01-01

In the paper the result of elemental analysis by Nuclear Techniques of Coal and Embedded rocks samples from Vietnamese Quang Ninh and Thai Nguyen basins were presented. Methods used were: Neutron activation Analysis at Dalat Reactor, low counting with HP-Ge and NaJ detectors and X-ray fluorescent analysis with planar Si (Si) detector. Mean concentrations of 19 elements in coal and 9 in rocks were determined. Correlation between concentrations of elements were found. It appears that the correlation between ash content and U, K, Th, concentrations was poor for Quang Ninh antracitecoal. Correlation coefficient was found to be 0,63 for ash range 0-40%. Content of Th in anthracite Quang Ninh coal was much higher than reported in literature for subbituminous, bituminous and lignite coals, while Thai Nguyen fat coal contains considerable amount of Cu, Pb, Zn. Obtained data were useful for evaluation of potential hazard for environment from using coal as fuel for coal fired power plants, for estimation of possibility of using nuclear technique in coal industry in Vietnam. They could be used also for geochemical investigations. The simple of-line coal ash gauge basing on attenuation of soft gamma radiation from Fe-55 was also described. (author). 6 refs, 3 figs, 8 tabs

"Da Vinci kood" tuleb Eestisse / Urve Eslas

Index Scriptorium Estoniae

Eslas, Urve, 1972-

2006-01-01

17. mail esilinastus Cannes'i filmifestivalil Dan Browni samanimelise menuromaani järgi valminud põnevusfilm "Da Vinci kood" : stsenarist Akiva Goldsman : režissöör Ron Howard : osades Tom Hanks, Audrey Tautou, Jean Reno : Ameerika Ühendriigid 2006

76 FR 53113 - Guidelines for Designating Biobased Products for Federal Procurement

Science.gov (United States)

2011-08-25

... Designating Biobased Products for Federal Procurement AGENCY: Office of Procurement and Property Management... that the Department of Agriculture, Office of Procurement and Property Management, is hereby requesting... comments to: Ron Buckhalt, USDA, Office of Procurement and Property Management, Room 361, Reporters...

Cannes : seks ja revolutsioon / Annika Koppel

Index Scriptorium Estoniae

Koppel, Annika

2006-01-01

Cannes'i filmifestival. Nähtud filmidest : Ron Howardi "Da Vinci kood"("The Code Da Vinci"), hiinlase Lou Ye "Suvepalee", inglase Ken Loach'i "Tuul, mis sasib odrapõldu" ("The Wind that Shakes the Barely"), ungarlase Györgi Palfi "Taksidermia"

Sfg

Science.gov (United States)

Fischer, R. X.; Baur, W. H.

This document is part of Subvolume E `Zeolite-Type Crystal Structures and their Chemistry. Framework Type Codes RON to STI' of Volume 14 `Microporous and other Framework Materials with Zeolite-Type Structures' of Landolt-Börnstein Group IV `Physical Chemistry'.

Globaalne peastsoojenemine : Bangkok / Mai Loog

Index Scriptorium Estoniae

Loog, Mai, 1960-

2006-01-01

Dan Browni samanimelise romaani järgi valminud põnevusfilm "Da Vinci kood" : režissöör Ron Howard : Ameerika Ühendriigid 2006. Tais lisati filmi algusse ja lõppu hoiatavad teated, et tegemist on väljamõeldisega

Filmi "Da Vinci kood" tõeline peategelane on kõigest raamat / Andris Feldmanis

Index Scriptorium Estoniae

Feldmanis, Andris, 1982-

2006-01-01

17. mail esilinastus Cannes'i filmifestivalil Dan Browni samanimelise menuromaani järgi valminud põnevusfilm "Da Vinci kood" : stsenarist Akiva Goldsman : režissöör Ron Howard : osades Tom Hanks, Audrey Tautou, Jean Reno : Ameerika Ühendriigid 2006

Katoliiklased nõuavad "Da Vinci koodi" muutmist

Index Scriptorium Estoniae

2006-01-01

Dan Browni samanimelise menuromaani järgi valminud põnevusfilm "Da Vinci kood" (režissöör Ron Howard, produtsent Brian Greiser, näitlejad Tom Hanks, Audrey Tautou, Jean Reno) on langenud usuorganisatsiooni Opus Dei kriitika alla

Naphtha vs. dieseline – The effect of fuel properties on combustion homogeneity in transition from CI combustion towards HCCI

KAUST Repository

Vallinayagam, R.; An, Yanzhao; S.Vedharaj; Sim, Jaeheon; Chang, Junseok; Johansson, Bengt

2018-01-01

The scope of this research study pertains to compare the combustion and emission behavior between naphtha and dieseline at different combustion modes. In this study, US dieseline (50% US diesel + 50% RON 91 gasoline) and EU dieseline (45% EU diesel

78 FR 55067 - Proposed Collection; Comment Request

Science.gov (United States)

2013-09-09

... technology. DATES: Consideration will be given to all comments received by November 8, 2013. ADDRESSES: You... Technologies Section, ATTN: Charles Pierce/Le'Ron Lawrence, 3000 Marine Corps Pentagon Rm 4A324, Washington, DC... biometric databases and associated [[Page 55068

Nguyen et al., Afr J Tradit Complement Altern Med. (2014) 11(4):136 ...

African Journals Online (AJOL)

cadewumi

Hep G2 cells treated with the formula showed increased gene ... Moutan Cortex; RdR, Radix Rehmanniae; ROS, Reactive oxygen species; ... decoction was routinely produced for clinical use in the Traditional Medicine Hospital HCMC.

Distribution and nests of paper wasps of Polistes (Polistella) in northeastern Vietnam, with description of a new species (Hymenoptera, Vespidae, Polistinae)

Science.gov (United States)

Nguyen, Lien Thi Phuong; Kojima, Jun-ichi

2014-01-01

Abstract Seven species of the subgenus Polistella Ashmead of the genus Polistes Latreille including a new species, P. brunetus Nguyen & Kojima, sp. n. described here, are recognized to occur in northeastern Vietnam, the easternmost part of the eastern slope of the Himalayas. A key to these species is provided. Their distributional records are remarked. Nests of P. delhiensis Das & Gupta, P. mandarinus de Saussure and P. brunetus are also described. PMID:24478582

A Study of Strategic Lessons Learned in Vietnam. Volume 8. Results of the War

Science.gov (United States)

1980-05-09

BDNI CORPORATION Political Bureau Membeirs (Fourth Party Congress ranking order) Le Duan fruong Chinh Phamn Van Dong Phamn Huna Le Duc Tho Vo Nguyen...the Laotian monarchy was abolished and the Democratic People’s Republic of Laos established. In a political trans - formation which passed with little...Strategic Studies, thus observed, " in the particular case of Vietnam, the general effect was to inaugurate a tran - sitional phase of Americao policy which

JPRS Report East Asia Southeast Asia.

Science.gov (United States)

1987-07-07

ni Kristo came out with its own list. It did not concern me a0 lot because INK never ■• supported me even before. But I won in the previous...1,000 kilometers of central coastline. Director Nguyen Chuoc talked about marine products now preferred by the foreign market. Besides shrimp, squid ...has been extracted from Vietnamese-language sources published in Hanoi, unless otherwise indicated. Asterisked job title indicates that this is the

Intelligence Operations In Small Wars: A Comparison Of The Malayan Emergency And Vietnam War

Science.gov (United States)

2013-04-01

Effect, 18. 41 Spencer C. Tucker, David Coffey, Nguyen Cong Luan, Nike Nichols, and Sandra Wittman, eds, Encyclopedia of the Vietnam War Volume One: A...War: The Unexamined Victories and Final Tragedy of America’s Last Years in Vietnam, (Orlando, FL :Harcourt, Inc ., 1999), 72-73. 91 Sorley, A Better...Victories and Final Tragedy of America’s Last Years in Vietnam. Orlando, FL: Harcourt, Inc ., 1999. Stubbs, Richard. Hearts and Minds in

The Role of ERK1/2 in the Progression of Anti-Androgen Resistance of mtDNA Deficient Prostate Cancer

Science.gov (United States)

2012-05-01

cancers are not viable if mitochondria as a whole are removed. Mitochondria serve multiple roles for the eukaryote including ATP synthesis , redox...transcriptional and/or translational regulation, PTMs, and/or proteasomal degradation by both sterol and non- sterol products of the mevalonate pathway (46, 47...intermediate in the synthesis of cholesterol. Cell Metab. 2005;1(3):179-89. 49. Nguyen AD, McDonald JG, Bruick RK, DeBose-Boyd RA. Hypoxia stimulates

Structural Model of the Effect of Psychological Capital on Success with Due to the Mediating Role of Commitment and Satisfaction

OpenAIRE

M Golparvar; Z Mirzaie

2016-01-01

This research was administered with the aim of investigating structural model of the effect of psychological capital on career success with due to the mediating role of satisfaction and commitment among employees of Telecom Company. Research statistical population was male and female employees of Telecom in Isfahan city, who among them two hundred and eighty five persons were selected using convenience sampling. Research instruments were Nguyen et al. Psychological Capital questionnaire, Nabi...

Multiple Kernel Learning with Data Augmentation

Science.gov (United States)

2016-11-22

JMLR: Workshop and Conference Proceedings 63:49–64, 2016 ACML 2016 Multiple Kernel Learning with Data Augmentation Khanh Nguyen nkhanh@deakin.edu.au...University, Australia Editors: Robert J. Durrant and Kee-Eung Kim Abstract The motivations of multiple kernel learning (MKL) approach are to increase... kernel expres- siveness capacity and to avoid the expensive grid search over a wide spectrum of kernels . A large amount of work has been proposed to

Obituary: Ronald N. Bracewell, 1921-2007

Science.gov (United States)

Petrosian, Vahé

2009-01-01

Ronald N. Bracewell, Professor Emeritus (since 1991) of Electrical Engineering at Stanford University, and a true renaissance man of science, died of a heart attack on 12 August 2007 at his home. Ron Bracewell was born in Sydney, Australia, on 22 July 1921, one of the two sons of Cecil and Valerie Bracewell. He graduated from the University of Sydney in 1941 and received his doctorate degree in physics from Cambridge University in 1949. During World War II, Ron worked in the Australian National Radar Establishment, where he designed and developed microwave radar equipment. Like several other World War II radar scientists, after the war he used this experience to pioneer the new field of radio astronomy. With J. L. Pawsey, in 1955 he published the first comprehensive textbook in this field entitled, Radio Astronomy. Bracewell joined the Stanford Electrical Engineering faculty in 1955, and from 1974 on he held the first prestigious Lewis Terman professorship. He was awarded the Outstanding Service Award of the department in 1984. In 1988, he was named an officer of the Order of Australia--the Australian equivalent of Order of the British Empire. Soon after his arrival at Stanford, Bracewell designed and began building a solar spectroheliograph, consisting of thirty-two dish antennas in the form of a cross. This was completed in 1961 and provided daily maps of the Sun for more than a decade encompassing more than one solar activity cycle of eleven years. These maps were useful in predicting magnetic storms caused by solar activity and were used by NASA during the first landing on the Moon. In 1971 he started the building of a five-element radio interferometer, for observation of extragalactic radio sources, with the novel design of unequal spacing that gave the resolution of a ten-element array. Both telescopes are now dismantled. The common characteristics of these and other projects were that they were all built in-house with a limited budget, often a small fraction

Effects of Heat of Vaporization and Octane Sensitivity on Knock-Limited Spark Ignition Engine Performance

Energy Technology Data Exchange (ETDEWEB)

Ratcliff, Matthew A [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Burton, Jonathan L [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Sindler, Petr [National Renewable Energy Laboratory (NREL), Golden, CO (United States); McCormick, Robert L [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Christensen, Earl D [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Fouts, Lisa A [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

2018-04-03

Knock-limited loads for a set of surrogate gasolines all having nominal 100 research octane number (RON), approximately 11 octane sensitivity (S), and a heat of vaporization (HOV) range of 390 to 595 kJ/kg at 25 degrees C were investigated. A single-cylinder spark-ignition engine derived from a General Motors Ecotec direct injection (DI) engine was used to perform load sweeps at a fixed intake air temperature (IAT) of 50 degrees C, as well as knock-limited load measurements across a range of IATs up to 90 degrees C. Both DI and pre-vaporized fuel (supplied by a fuel injector mounted far upstream of the intake valves and heated intake runner walls) experiments were performed to separate the chemical and thermal effects of the fuels' knock resistance. The DI load sweeps at 50 degrees C intake air temperature showed no effect of HOV on the knock-limited performance. The data suggest that HOV acts as a thermal contributor to S under the conditions studied. Measurement of knock-limited loads from the IAT sweeps for DI at late combustion phasing showed that a 40 vol% ethanol (E40) blend provided additional knock resistance at the highest temperatures, compared to a 20 vol% ethanol blend and hydrocarbon fuel with similar RON and S. Using the pre-vaporized fuel system, all the high S fuels produced nearly identical knock-limited loads at each temperature across the range of IATs studied. For these fuels RON ranged from 99.2 to 101.1 and S ranged from 9.4 to 12.2, with E40 having the lowest RON and highest S. The higher knock-limited loads for E40 at the highest IATs examined were consistent with the slightly higher S for this fuel, and the lower engine operating condition K values arising from use of this fuel. The study highlights how fuel HOV can affect the temperature at intake valve closing, and consequently the pressure-temperature history of the end gas leading to more negative values of K, thereby enhancing the effect of S on knock resistance.

Chemical Kinetic Insights into the Octane Number and Octane Sensitivity of Gasoline Surrogate Mixtures

KAUST Repository

Singh, Eshan

2017-02-01

Gasoline octane number is a significant empirical parameter for the optimization and development of internal combustion engines capable of resisting knock. Although extensive databases and blending rules to estimate the octane numbers of mixtures have been developed and the effects of molecular structure on autoignition properties are somewhat understood, a comprehensive theoretical chemistry-based foundation for blending effects of fuels on engine operations is still to be developed. In this study, we present models that correlate the research octane number (RON) and motor octane number (MON) with simulated homogeneous gas-phase ignition delay times of stoichiometric fuel/air mixtures. These correlations attempt to bridge the gap between the fundamental autoignition behavior of the fuel (e.g., its chemistry and how reactivity changes with temperature and pressure) and engine properties such as its knocking behavior in a cooperative fuels research (CFR) engine. The study encompasses a total of 79 hydrocarbon gasoline surrogate mixtures including 11 primary reference fuels (PRF), 43 toluene primary reference fuels (TPRF), and 19 multicomponent (MC) surrogate mixtures. In addition to TPRF mixture components of iso-octane/n-heptane/toluene, MC mixtures, including n-heptane, iso-octane, toluene, 1-hexene, and 1,2,4-trimethylbenzene, were blended and tested to mimic real gasoline sensitivity. ASTM testing protocols D-2699 and D-2700 were used to measure the RON and MON of the MC mixtures in a CFR engine, while the PRF and TPRF mixtures’ octane ratings were obtained from the literature. The mixtures cover a RON range of 0–100, with the majority being in the 70–100 range. A parametric simulation study across a temperature range of 650–950 K and pressure range of 15–50 bar was carried out in a constant-volume homogeneous batch reactor to calculate chemical kinetic ignition delay times. Regression tools were utilized to find the conditions at which RON and MON

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African Journals Online (AJOL)

"second" language is Portuguese. Also Preben Kaarsholm, from the. University of Copenhagen, draws intriguing comparisons between popular political and cultural movements in Denmark and Zimbabwe. The other contribution from Scandinavia, by Helge Ronning, deals with the general theme under which these essays ...

77 FR 71796 - Proposed Data Collections Submitted for Public Comment and Recommendations

Science.gov (United States)

2012-12-04

... been limited in laboratory medicine. No single- evidence-based model for recommending practices in... of laboratory tests available certainly warrant such a model. The Laboratory Medicine Best Practices..., 2012. Ron A. Otten, Director, Office of Scientific Integrity (OSI), Office of the Associate Director...

Creating Modular Platforms for Strategic Flexibility

DEFF Research Database (Denmark)

Sanchez, Ron

2004-01-01

In developing products, long‐term success depends on designing components that facilitate the creation of a family of current and future product options. Ron Sanchez emphasizes that this requires careful planning of shared technologies and production processes. The payoff is a modular approach...

Staff members with 25 years' service at CERN in 2012

CERN Multimedia

HR Department

2012-01-01

The 27 staff members who have spent 25 years within CERN in 2012 were invited by the Director-General to a reception in their honour on 2 November.   BARRIN Laurence  -  PH BILLEN Ronald  -  BE BOUCHÉ Jean-Marc  -  HR BURKHARDT Helmut  -  BE CARLIER Etienne  -  TE CASS Antony  -  IT CHAN KWOK CHEON Anne Belinda  -  IT CHARRUE Pierre  -  BE COLLIER Paul  -  BE CUENCA PEREZ Antonio  -  GS DE JONGHE Jurgen  -  GS DEFERT Philippe  -  IT ELSENER Konrad  -  PH FROIDEVAUX Daniel  -  PH GRIGGS Christopher  -  PH MATHEYS Jean-Pol  -  HR MEIJERS Franciscus  -  PH MERTENS Volker  -  TE METRAL Gabriel  -  BE NECCA Rene  -  EN PACE Alberto&...

The GaN trench gate MOSFET with floating islands: High breakdown voltage and improved BFOM

Science.gov (United States)

Shen, Lingyan; Müller, Stephan; Cheng, Xinhong; Zhang, Dongliang; Zheng, Li; Xu, Dawei; Yu, Yuehui; Meissner, Elke; Erlbacher, Tobias

2018-02-01

A novel GaN trench gate (TG) MOSFET with P-type floating islands (FLI) in drift region, which can suppress the electric field peak at bottom of gate trench during the blocking state and prevent premature breakdown in gate oxide, is proposed and investigated by TCAD simulations. The influence of thickness, position, doping concentration and length of the FLI on breakdown voltage (BV) and specific on-resistance (Ron_sp) is studied, providing useful guidelines for design of this new type of device. Using optimized parameters for the FLI, GaN FLI TG-MOSFET obtains a BV as high as 2464 V with a Ron_sp of 3.0 mΩ cm2. Compared to the conventional GaN TG-MOSFET with the same structure parameters, the Baliga figure of merit (BFOM) is enhanced by 150%, getting closer to theoretical limit for GaN devices.

Characteristics of Superjunction Lateral-Double-Diffusion Metal Oxide Semiconductor Field Effect Transistor and Degradation after Electrical Stress

Science.gov (United States)

Lin, Jyh‑Ling; Lin, Ming‑Jang; Lin, Li‑Jheng

2006-04-01

The superjunction lateral double diffusion metal oxide semiconductor field effect has recently received considerable attention. Introducing heavily doped p-type strips to the n-type drift region increases the horizontal depletion capability. Consequently, the doping concentration of the drift region is higher and the conduction resistance is lower than those of conventional lateral-double-diffusion metal oxide semiconductor field effect transistors (LDMOSFETs). These characteristics may increase breakdown voltage (\\mathit{BV}) and reduce specific on-resistance (Ron,sp). In this study, we focus on the electrical characteristics of conventional LDMOSFETs on silicon bulk, silicon-on-insulator (SOI) LDMOSFETs and superjunction LDMOSFETs after bias stress. Additionally, the \\mathit{BV} and Ron,sp of superjunction LDMOSFETs with different N/P drift region widths and different dosages are discussed. Simulation tools, including two-dimensional (2-D) TSPREM-4/MEDICI and three-dimensional (3-D) DAVINCI, were employed to determine the device characteristics.

Effect of antioxidant supplementation on insulin sensitivity in response to endurance exercise training

DEFF Research Database (Denmark)

Yfanti, Christina; Nielsen, Anders R; Åkerström, Thorbjörn

2011-01-01

While production of reactive oxygen and nitrogen species (RONS) is associated with some of the beneficial adaptations to regular physical exercise, it is not established whether RONS play a role in the improved insulin-stimulated glucose uptake in skeletal muscle obtained by endurance training....... To assess the effect of antioxidant supplementation during endurance training on insulin-stimulated glucose uptake, twenty-one young healthy (age 29±1 y; BMI 25±3 Kg m(-2)) men were randomly assigned into either an antioxidant (AO; 500 mg vitamin C and 400 IU vitamin E (a-tocopherol) daily) or a placebo (PL......) group that both underwent a supervised intense endurance-training program, 5 times per week for 12 weeks. A 3-hour euglycemic-hyperinsulinemic clamp, a maximal oxygen consumption (VO(2max)) and maximal power output (P(max)) test, and body composition measurements (fat mass, fat-free mass) were performed...

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS

Directory of Open Access Journals (Sweden)

Javier Egea

2017-10-01

Full Text Available The European Cooperation in Science and Technology (COST provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.

THE RESULTS OF RADIAL OPTIC NEUROTOMY FOR TREATMENT OF CENTRAL RETINAL VEIN OCCLUSION

Directory of Open Access Journals (Sweden)

S A Tabatabaii

2008-11-01

Full Text Available "nCentral retinal vein occlusion (CRVO is the third most common blinding vascular retinal disorder. As there is no proven treatment for CRVO, we performed this study to evaluate the effectiveness of radial optic neurotomy (RON on visual acuity in eyes with CRVO. This study was designed as an interventional case series. Pars plana vitrectomy with RON was performed in 18 eyes of 16 patients with ischemic CRVO with visual acuities of 20/400 or less. Postoperative and preoperative visual acuities were compared using t paired test. Mean preoperative visual acuity was 20/1000 (range, 20/1600 to 20/630. Mean follow-up time was 3.6 months (range, 1 to 9 months. Mean postoperative visual acuity was 20/400 (range, 20/1600 to 20/50 at last follow-up and the difference was significant (P < 0.01; t paired test. Six patients (33% improved to 20/200 postoperatively. There were no major complications intraoperatively. Chorioretinal shunts developed in neurotomy site in 9 cases (50% 4 to 10 weeks after procedure which were associated with faster resolving of hemorrhage and venous dilation. There were no major complications noted with this procedure but vitreous hemorrhage and iris neovascularization was observed in the early postoperative period in 2 (11% of 18 cases. RON may improve visual acuity in eyes with CRVO. It is a technically feasible and fairly safe procedure but postoperatively it may result in some complications such as vitreous hemorrhage, iris neovascularization and retinal detachment.

77 FR 61379 - Performance Review Board Membership

Science.gov (United States)

2012-10-09

... DEPARTMENT OF COMMERCE Performance Review Board Membership AGENCY: Economics and Statistics... eligible to serve on the Performance Review Board (PRB) in accordance with the Economics and Statistics.... Arnold William G. Bostic, Jr. Joanne Buenzli Crane Justin R. Ehrenwerth Ron S. Jarmin Theodore A. Johnson...

78 FR 67333 - Performance Review Board Membership

Science.gov (United States)

2013-11-12

... DEPARTMENT OF COMMERCE Performance Review Board Membership AGENCY: Economics and Statistics... eligible to serve on the Performance Review Board (PRB) in accordance with the Economics and Statistics.... Arnold William G. Bostic, Jr. Stephen B. Burke Joanne Buenzli Crane Susan R. Helper Ron S. Jarmin Enrique...

Compression ignition of light naphtha and its multicomponent surrogate under partially premixed conditions

NARCIS (Netherlands)

Vallinayagam, R.; Vedharaj, S.; An, Y.; Dawood, A.; Izadi Najafabadi, M.; Somers, B.; Chang, J.; Sarathy, M.; Johansson, B.

2017-01-01

Light naphtha is the light distillate from crude oil and can be used in compression ignition (CI) engines; its low boiling point and octane rating (RON = 64.5) enable adequate premixing. This study investigates the combustion characteristics of light naphtha (LN) and its multicomponent surrogate

Reminiscences from Pittendrigh's Last PhD Student

Indian Academy of Sciences (India)

When Ron Konopka came to Pitt for advice on searching for clock mutants in .... As a mentor of my graduate research, Pitt was very "hands-off" and not very interested ... projects) were OUR projects - not his projects - and he was good at giving ...

Meelelahutus on meelelahutus / Jaak Lõhmus

Index Scriptorium Estoniae

Lõhmus, Jaak

2006-01-01

17. mail esilinastus Cannes'i filmifestivalil Dan Browni samanimelise menuromaani järgi valminud põnevusfilm "Da Vinci kood" (režissöör Ron Howard). Filmi linastuse järel toimunud pressikonverentsist, kus olid kohal nii lavastaja kui staarid ja rekordarv ajakirjanikke

Kod Da Vintshi. Tserkov protiv / Maria Tsheskis

Index Scriptorium Estoniae

Tsheskis, Maria

2006-01-01

Esilinastus Dan Browni samanimelise menuromaani järgi valminud põnevusfilm "Da Vinci kood" : stsenarist Akiva Goldsman : režissöör Ron Howard : osades Tom Hanks, Audrey Tautou, Jean Reno : Ameerika Ühendriigid 2006. Vastukajad ja skandaalid, eelkõige religioossete ringkondade poolt

Shirak rekomendoval aktrissu dlja "Koda da Vintshi" / Stefano Montefiori

Index Scriptorium Estoniae

Montefiori, Stefano

2006-01-01

Dan Browni samanimelise menuromaani järgi valmiva filmi "Da Vinci kood" võtteperioodile Prantsusmaal eelnes režissööri ja produtsendi külaskäik president J. Chiraci juurde. Režissöör Ron Howard, produtsent Brian Greiser

Saturday Programme for CineGlobe

CERN Multimedia

Marcelloni De Oliveira, Claudia

2015-01-01

The saturday programme had a special kids session, the kick of the Science Storytelling Hackaton and the Award Ceremony WINNERS 2015 The Jury Prize for documentary: Fecal Matters, Paul Gallasch - AU The Jury Prize for Fiction: Hybris, Arjan Brentjes - NL Award of Excellence in Narrative: Final Draft, Scott Calonico - UK The Audience Award for documentary: Logically policed, Damiano Petrucci - UK The Audience Award for Fiction: Slapkick, Dat Nguyen Chon-- DE The Special Prize "Time Vizualisation": Danielle, Anthony Cerniello - US

The Synthesis of Force Closure Grasps in the Plane.

Science.gov (United States)

1985-09-01

TASK U Artificial Inteligence Laboratory AREA A WORK UN IT "NMUIERS ~( 545 Technology Square Cambridge, MA 02139 SI. CONTROLLING OFICE NAME ANO... ARTIFICIAL INThLLIX’ ENCE LABORATORY A. 1. Memo 861 September, 1985 The Synthesis of Force-Closure Grasps In the Plane DTIC ’VeL% ,#ECTE 1 VnDcNguyenU Abstract... Artificial In- telligenmcc Liabomatory of thle Massachuset Is hInsttute of Teclhnolog3 . Support for the Lahoratot * s Artificial Intelligence research is

The Role of Microglial Subsets in Regulating Traumatic Brain Injury

Science.gov (United States)

2013-07-01

Delineation  of   diverse   macrophage   activation   programs   in   response   to   intracellular   parasites   and   cytokines... helminths , to allergens, by adipose tissue, and in vitro by IL-4 [20, 21]. M2 macrophages suppress inflammation and promote wound healing [14]. They...molecules in type 2 inflammation: lessons drawn from helminth infection and allergy. J. Immunol. 2006. 177: 1393–1399. 21 Nguyen, K. D., Qiu, Y., Cui, X

Southeast Asia Report, Vietnam, Tap Chi Cong San, No. 8, August 1984.

Science.gov (United States)

1984-10-22

filled with lyricism and romance, an epic. Continuing this direction and style, recent films have taken another step forward, have reached a new level of...rich in lyricism , were compressed but moving, like poetry, and whereas the resistance against the United States for national salvation marked the...in the " Essay on the Vinh Loi Canal," Nguyen Thong displayed his scientific mind by proposing that the canal be narrow and deep so that it could

Promise of a microfluidic research network in South Africa: establishment of the base with the CSIR

CSIR Research Space (South Africa)

Land, K

2008-11-01

Full Text Available and pharmaceutical production. This technology requires a range of multidisciplinary skills, which solicits skills and knowledge sharing between organisations to ensure competitiveness. While research activities in this fi eld are still minimal in South Africa... to form what is known as a ʻlab-on-chipʼ device. Lab-on-chip devices are used for performing physical, chemical, or biological functions, such as separation, mixing, chemical reaction and analysis (Liu et al. 2008; Nguyen & Wereley, 2006...

A Chemically Synthesized Capture Agent Enables the Selective, Sensitive, and Robust Electrochemical Detection of Anthrax Protective Antigen

Science.gov (United States)

2014-08-01

Electrochemical Oxidation of Catechol and Para - Aminophenol Esters in the Presence of Hydrolases. Bioelectrochem. Bioenerg. 1980, 7, 11–24. 26. Evans-Nguyen, K. M...platform. Analytical HPLC (a) and MALDI-TOF (b) traces of biligand capture agentwithno thermal treatment, and after 5 days of storage as a powder at...sample of biligand was stored for 5 days at 65 C under nitrogen atmosphere. Analy- tical HPLC traces (Figure 4a) andMALDI-TOF (Figure 4b) reveal

Designing Medical Facilities to Care for Patients with Highly Hazardous Communicable Diseases

Science.gov (United States)

2017-07-14

experience in biocontainment patient care. Pub Health Nursing 2010;140-6. 25Lowe JJ , Jelden KC, Schenarts PJ, Rupp LE, Jr, Hawes KJ, Tysor BN, Swansiger RG...units. Curr Opin-Infect Dis 2015;28:343-8. 27 Wadman MC, Schwedhelm SS, Watson S, Swanhorst J, Gibbs SG, Lowe JJ , Iwen PC, Hayes AK, Needham S...30 Lowe JJ , Gibbs SG, Schwedhelm SS, Nguyen J, Smith PW. Nebraska biocontainment unit perspective on disposal of Ebola medical waste. Am J Infect

Investigating Metabolic Control of Persister Formation in Biofilms

Science.gov (United States)

2013-10-01

Beer , K., McKay, G., Siehnel, R., Schafhauser, J., Wang, Y., et al. (2011). Active starva- tion responses mediate antibiotic tolerance in biofilms and...ATP concentration in Escherichia coli fermentations . Biotechnology and bioengineering 52, 364-372. Lemke, J.J., Sanchez-Vazquez, P., Burgos, H.L...1082– 1093. 33. Nguyen D, Joshi-Datar A, Lepine F, Bauerle E, Olakanmi O, Beer K, McKay G, Siehnel R, Schafhauser J, Wang Y, Britigan BE, Singh PK. 2011

Perceptions of community and family level IDU and HIV related stigma, disclosure decisions and experiences with layered stigma among HIV positive injection drug users in Vietnam

OpenAIRE

Rudolph, A.E.; Davis, W.W.; Quan, V.M.; Ha, T.V.; Minh, N.L.; Gregowski, A.; Salter, Megan; Celentano, D.D.; Go, V.

2011-01-01

This paper explores how perceived stigma and layered stigma related to injection drug use and being HIV positive influence the decision to disclose one’s HIV status to family and community and experiences with stigma following disclosure among a population of HIV positive male injection drug users (IDUs) in Thai Nguyen, Vietnam. In qualitative interviews conducted between 2007 and 2008, 25 HIV positive male IDUs described layered stigma in their community but an absence of layered stigma with...

International Symposium on Special Topics in Chemical Propulsion (8th): Advancements in Energetic Materials and Chemical Propulsion Held in Cape Town, South Africa on 2-6 November 2009

Science.gov (United States)

2009-11-06

Mark Morgan4 USA Dr. Tam Nguyen9,7,6,1,2 Australia Prof. Takashi Niioka6,8 Japan Prof. Boris V. Novozhilov6,8 Russia Dr. Elaine S. Oran8 USA Dr...predicted to continue for the foreseeable future. The lessons learned from other international peacekeeping forces in foreign countries, has a direct...reprocessing or blending again to meet the specific requirements. Another advantage is that after mixing, the excess product can be reheated and used

Optimization of GaN Nanorod Growth Conditions for Coalescence Overgrowth

Science.gov (United States)

2016-02-04

21, 2016 PI: Chih-Chung (C. C.) Yang, ccycc@ntu.edu.tw Graduate Institute of Photonics and Optoelectronics, National Taiwan University...nanowire light emitting diodes grown on (001) silicon by molecular beam epitaxy, Nano Lett. 10 (2010) 3355-3359. [16] W. Guo, A. Banerjee, P...Bhattacharya, B.S. Ooi, InGaN/GaN disk-in-nanowire white light emitting diodes on (001) silicon , Appl. Phys. Lett. 98 (2011) 193102. [17] H.P.T. Nguyen, M

ron Intake in Adults from Medellin According to Demographics, 2012

Directory of Open Access Journals (Sweden)

Carmen Yulieth Mantilla Gutiérrez

2014-05-01

Full Text Available Objectives: To analyze the iron intake in healthy adults of Medellín according to demographics, and to determine the association between the consumption of iron and hemoglobin in this popula¬tion. Materials and methods: Cross-sectional study in 109 subjects. We applied a semiquantitative survey of food consumption frequency source of iron given the frequency of consumption and portion. Summary measures, frequencies, Mann Whitney, Kruskal Wallis ANOVA and Spearman correlation were calculated. We used SPSS version 20.0, considering a significance level of 0.05. Results: The mean age subjects was 32, 64.2 % were female, 81.6 % with technical or university studies, 29.3 % students and 43.9 % of low socioeconomic status. We found a daily intake of 12.3 mg/day on average, 61 % from non-heme iron. The total iron consumed was statistically higher in unemployed subjects than in workers, students and housewives. The heme iron intake was statistically higher in individuals with graduate. No statistically significant differences were observed when comparing iron consumption by sex, age group and hemoglobin. Conclusions: The low intake of iron is not influenced by sex or age group, but by occupation and education, and is a factor that cannot reduce the prevalence of iron and other micronutrients deficiencies. It requires to implement more and better strategies for nutrition education and increased avail¬ability, production and consumption of safe food

The Importance of Character Development: An Interview with Ron Kinnamon.

Science.gov (United States)

Kinnamon, Ron

2003-01-01

Building good character in today's youth is an adult issue because children learn values from adults. Adults must demonstrate the core values: trustworthiness, respect, responsibility, fairness, caring, and citizenship. Camps have developed expertise in character development and can provide leadership in the community in character education.…

DETECTING REGIME SWITCHES IN THE EUR/RON EXCHANGE RATE VOLATILITY

Directory of Open Access Journals (Sweden)

Radu Alina-Nicoleta

2009-05-01

Full Text Available In the present study we develop and implement a short term exchange rate forecasting methodology using dynamic confidence intervals based on GARCH processes and we analyze whether this methodology can be used to model a regime switch in the volatility of

77 FR 76494 - Changes in Flood Hazard Determinations

Science.gov (United States)

2012-12-28

..., Suite 11, Downieville, CA 95936. Colorado: Arapahoe (FEMA Docket No.: B- City of Centennial The... Authority, 76 of Centennial, Inverness Drive East, 13133 East Arapahoe Suite A, Centennial, CO Road, Centennial, 80112. CO 80112. Arapahoe (FEMA Docket No.: B- City of Greenwood The Honorable Ron City Hall...

75 FR 38768 - Ashley National Forest, UT, High Uintas Wilderness-Colorado River Cutthroat Trout Habitat...

Science.gov (United States)

2010-07-06

... remove competing and hybridizing nonnative fish species from selected streams and lakes within the High... selected lakes and associated stream segments in the Garfield Basin and Swasey Hole in the Yellowstone... comments to Ron Brunson, Roosevelt/Duchesne Ranger District, P.O. Box 981, Duchesne, Utah 84021. Comments...

77 FR 61413 - Proposed Data Collections Submitted for Public Comment and Recommendations

Science.gov (United States)

2012-10-09

... cities to determine its feasibility, cost, and effectiveness. In the evaluation, a standard model of TDV prevention (Safe Dates administered in 8th grade) will be compared to a comprehensive model (programs.... Ron A. Otten, Director, Office of Scientific Integrity (OSI), Office of the Associate Director for...

QuEChERS, a sample preparation technique that is “catching on”: an up-to-date interview with its inventors

Science.gov (United States)

The technique of QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) is only 7 years old, yet it is revolutionizing the manner in which multiresidue, multiclass pesticide analysis (and perhaps beyond) is performed. Columnist Ron Majors sits down with inventors Steve Lehotay and Michelangelo An...

Incorporation of diet information derived from Bayesian stable isotope mixing models into mass-balanced marine ecosystem models: A case study from the Marennes-Oleron Estuary, France

Science.gov (United States)

We investigated the use of output from Bayesian stable isotope mixing models as constraints for a linear inverse food web model of a temperate intertidal seagrass system in the Marennes-Oléron Bay, France. Linear inverse modeling (LIM) is a technique that estimates a complete net...

Debate on the Draft--Helping Students Decide Where They Stand.

Science.gov (United States)

Victory, James

1981-01-01

Presents four exercises to help secondary school social studies students understand the complex issues of the draft. Students participate in a mock draft lottery, analyze Phil Och's Draft Dodger Rag, examine how individual experiences affect attitudes, and compare writings by Bill Mauldin and Ron Kovic. (KC)

SUPPLEMENTTNG SHEEP WITH PROTEIN AND PHOSPHORUS ...

African Journals Online (AJOL)

showing excessive quantities of saliva or contaminated with regurgitated material were discarded. Drinking ... However, a higher than normal prcciprtat ron was recorded in September 1971 while the early sunrnrcr ..... Ph. D. thesis, University of Stellenbosch. ENGEIS, E.A.N. & MALAN, A., 1978. De invloed van twee ...

From physical inactivity to immobilization: Dissecting the role of oxidative stress in skeletal muscle insulin resistance and atrophy.

Science.gov (United States)

Pierre, Nicolas; Appriou, Zephyra; Gratas-Delamarche, Arlette; Derbré, Frédéric

2016-09-01

In the literature, the terms physical inactivity and immobilization are largely used as synonyms. The present review emphasizes the need to establish a clear distinction between these two situations. Physical inactivity is a behavior characterized by a lack of physical activity, whereas immobilization is a deprivation of movement for medical purpose. In agreement with these definitions, appropriate models exist to study either physical inactivity or immobilization, leading thereby to distinct conclusions. In this review, we examine the involvement of oxidative stress in skeletal muscle insulin resistance and atrophy induced by, respectively, physical inactivity and immobilization. A large body of evidence demonstrates that immobilization-induced atrophy depends on the chronic overproduction of reactive oxygen and nitrogen species (RONS). On the other hand, the involvement of RONS in physical inactivity-induced insulin resistance has not been investigated. This observation outlines the need to elucidate the mechanism by which physical inactivity promotes insulin resistance. Copyright © 2015 Elsevier Inc. All rights reserved.

The Dregs of Romulus. Stoic Philosophy in Cicero’s Pro Murena and De Oratore

Directory of Open Access Journals (Sweden)

Margaret Graver

2017-05-01

The dregs of Romulus examine la preuve de l’attitude de Cicéron à l’égard de la philosophie stoïcienne dans le discours pro Murena, dans des lettres de 61 à 60 se référant à Caton et au de Oratore. Aucun de ces textes n’exprime une opposi-tion directe au postulat de base de l’éthique stoïcienne, à savoir que seul ce qui est honorable est bon pour un être humain. Ce que nous trouvons dans ce groupe d’oeuvres est une préoccupation selon laquelle l’adhésion à un système dogma-tique d’éthique (1 entrave la communication politique, et (2 écarte la flexibilité d’application requise pour la prise de décision morale dans des situations com-plexes. La position de Cicéron en tant que politicien philosophiquement formé est définie en conséquence.

The Influence of Strategic Alternatives on the Increasing Level Value of the Term Deposits

Directory of Open Access Journals (Sweden)

Mirela Catalina Turkes

2015-03-01

Full Text Available This article analyses the influence of the strategic alternative on the value level increase of the term deposits attracted from the Romanian’s population households, during the period 2012 – Q1/2015, depending on the change of the standards related to deposits granting in RON, EURO and other currencies, but also depending on the aggregate volume of deposits demand at a national level. One-way ANOVA represents the ideal model to emphasize that the average of the term deposits attracted from the population’s households during the last four years is influenced by the strategic alternative used by the credit institutions. The results of this analysis underlined the fact that there is a strong link between the strategic alternative adopted by the banks and the change of the value level of the term deposits intended for the population. The strategies to attract RON deposits proved to be more efficient compared to the strategies adopted by the banks for other currencies.

Oxidative Stress and Antioxidant Defense Mechanisms Linked to Exercise During Cardiopulmonary and Metabolic Disorders

Directory of Open Access Journals (Sweden)

Kelsey Fisher-Wellman

2009-01-01

Full Text Available Oxidative stress has been implicated in the pathophysiology of multiple human diseases, in addition to the aging process. Although various stimuli exist, acute exercise is known to induce a transient increase in reactive oxygen and nitrogen species (RONS, evident by several reports of increased oxidative damage following acute bouts of aerobic and anaerobic exercise. Although the results are somewhat mixed and appear disease dependent, individuals with chronic disease experience an exacerbation in oxidative stress following acute exercise when compared to healthy individuals. However, this increased oxidant stress may serve as a necessary “signal” for the upregulation in antioxidant defenses, thereby providing protection against subsequent exposure to prooxidant environments within susceptible individuals. Here we present studies related to both acute exercise-induced oxidative stress in those with disease, in addition to studies focused on adaptations resulting from increased RONS exposure associated with chronic exercise training in persons with disease.

Wall shear stress measurement of near-wall flow over inclined and curved boundaries by stereo interfacial particle image velocimetry

International Nuclear Information System (INIS)

Nguyen, Thien Duy; Wells, John Craig; Nguyen, Chuong Vinh

2010-01-01

In investigations of laminar or turbulent flows, wall shear is often important. Nevertheless, conventional particle image velocimetry (PIV) is difficult in near-wall regions. A near-wall measurement technique, named interfacial PIV (IPIV) [Nguyen, C., Nguyen, T., Wells, J., Nakayama, A., 2008. Proposals for PIV of near-wall flow over curved boundaries. In: Proceedings of 14th International Symposium on Applications of Laser Technique to Fluid Mechanics], handles curved boundaries by means of conformal transformation, directly measures the wall gradient, and yields the near-wall tangential velocity profile at one-pixel resolution. In this paper, we show the feasibility of extending IPIV to measure wall gradients by stereo reconstruction. First, we perform a test on synthetic images generated from a direct numerical simulation (DNS) snapshot of turbulent flow over sinusoidal bed. Comparative assessment of wall gradients derived by IPIV, stereo-IPIV and particle image distortion (PID) [Huang, H.T., Fiedler, H.E., Wang, J.J., 1993. Limitation and improvement of PIV. Experiments in Fluids 15(4), 263-273] is evaluated with DNS data. Also, the sensitivity of IPIV and stereo-IPIV results to the uncertainty of identified wall position is examined. As a practical application of IPIV and stereo-IPIV to experimental images, results from turbulent open channel flow over a backward-facing step are discussed in detail.

Why are [P(C6H5)4]+N3- and [As(C6H5)4]+N3- Ionic Salts and Sb(C6H5)4N3 and Bi(C6H5)4N3 are Covalent Solids? A Theoretical Study Provides an Unexpected Answer

Science.gov (United States)

2011-03-04

Research, the Defense Threat Reduction Agency, and the Department of Energy. DAD is indebted to the Robert Ramsay Endowment of the University of Alabama...Schmidt, M. W., Baldridge, K. K., Boatz, J.A., Elbert, S.T., Gordon , M.S., Jensen, J.H., Koseki, S., Matsunaga, N., Nguyen, K.A., Su, S., Windus, T.L...Dupuis, M., Montgomery, J.A.; J. Comput. Chem., 1993, 14, 1347-1363.; Gordon , M. S., Schmidt, M. W., pp. 1167-1189, in "Theory and Applications of

Study of the role of microbes as source and sink of Dimethyl Sulphide in Dona Paula bay

Digital Repository Service at National Institute of Oceanography (India)

Kumar, S.S.

, Rassoulzadegan F, Krajka B, Nguyen BC, Mihalopoulos N, Buat- Menard P (1990) Production of dimethylsulfonium propionate (DMSP) and Dimethylsulfide (DMS) by a microbial food web. Limnology and Oceanography 35:1810 - 1821 Belviso S, Moulin C. Bopp L, Stefels J...-like dimethyl sulfide- producing marine isolate. Applied and Environmental Microbiology 61: 21 - 26 de Souza M P &Yoch D C (1996) N-terminal amino acid sequences and comparison of DMSP lyases from Pseudomonas doudoroffii and Alcaligenes strain M3A,. In R P...

A systematic review of interventions conducted in clinical or community settings to improve dual-task postural control in older adults

OpenAIRE

Agmon M; Belza B; Nguyen HQ; Logsdon RG; Kelly VE

2014-01-01

Maayan Agmon,1 Basia Belza,2 Huong Q Nguyen,2,3 Rebecca G Logsdon,2 Valerie E Kelly41The Cheryl Spencer Department of Nursing, Faculty of Social Welfare and Health Studies, University of Haifa, Israel; 2School of Nursing, University of Washington, Seattle, WA, USA; 3Department of Research and Evaluation, Kaiser Permanente, CA, USA; 4School of Medicine, University of Washington, Seattle, WA, USABackground: Injury due to falls is a major problem among older adults. Decrements in dual-task postu...

New records of petiolate potter wasps (Hymenoptera: Vespidae: Eumeninae from Bhutan

Directory of Open Access Journals (Sweden)

Tshering Nidup

2016-10-01

Full Text Available A total of seven species from five genera, Delta de Saussure, 1855, Eumenes Latreille, 1802, Pareumenes (de Saussure, 1855, Labus de Saussure, 1867, and Zethus Fabricius, 1804, belonging to the subfamily Eumeninae of the family Vespidae are documented. Pareumenes quadrispinosus acutus Liu, 1941, Delta esuriens (Fabricius, 1787, D. conoideum (Gmelin, 1790, E. gibbosus Nguyen, 2015, Labus pusillus van der Vecht, 1963 and Zethus dolosus Bingham, 1897, including the subspecies P. q. acutus Liu, 1941, are new records for Bhutan. 

JPRS Report, East Asia, Vietnam: TAP CHI CONG SAN, No. 10, October 1987

Science.gov (United States)

1988-02-09

Followers in the Countries of Latin America [ Tran Anh] 48 JPRS-ATC-88-002 9 February 1988 VIETNAM: TAP CHI CONG SAN No 10, October 1987 [Except...character is not simply an ideological-political category applied in literature. Our party, as Truong Chinh said at the Third National Literature and Art...Hanoi TAP CHI CONG SAN in Vietnamese No 10, Oct 87pp 39-42 [Article by Nguyen Dang Quang, assistant editor-in-chief of GIAO DUC LY LUAN Journal

Bandwidth Extension of an S-band, Fundamental-Mode Eight-Beam Klystron

Science.gov (United States)

2006-04-01

Extension of an S - band , Fundamental-Mode Eight-Beam Klystron Khanh T. Nguyen Beam-Wave Research, Inc. Bethesda, MD 20814 Dean E. Pershing ATK Mission...of a five-cavity, approximately 18 cm downstream from the center of the broadband, high - power multiple-beam klystron (MBK) first gap - the logical...the circuit generates >550 kW across the band with a peak power of more than 600 kW at -3.27 Keywords: Multiple-beam klystron ; MBK; bandwidth GHz. The 1

Leader/Follower Behaviour Using the SIFT Algorithm for Object Recognition

Science.gov (United States)

2006-06-01

opérations de convoiement plus complexes qui utiliseraient une vision artificielle basée sur la détection d’un chef. Les travaux futurs : Étant donné la...Systems: A Virtual Trailer Link Model, In Proceedings of IEEE/RSJ Conference on Intelligent Robots and Systems. [4] Hong, P., Sahli, H., Colon, E., and... Intelligent Robots and Systems. [6] Nguyen, H., Kogut, G., Barua, R., and Burmeister, A. (2004), A Segway RMP-based Robotic Transport System, In In

Publications | Page 85 | IDRC - International Development Research ...

International Development Research Centre (IDRC) Digital Library (Canada)

Results 841 - 850 of 7327 ... ... and offer free training materials to guide researchers and institutions. ... Despite strong economic growth, the Philippines has the highest ... is anchored on addressing the basic needs of its people through governance reform. ... says Ron Deibert, director of the digital watchdog group Citizen Lab.

Academic Futures: Prospects for Post-Secondary Education.

Science.gov (United States)

Shere, Waris, Ed.; Duhamel, Ronald, Ed.

Present trends and future directions in postsecondary education in Canada and the United States are addressed in 15 essays and an introduction by Ron Duhamel. Authors and titles are as follows: "Traditional Values in the Contemporary University" (Robin H. Farquhar); "Facing the Future" (R. J. Duhamel); "Challenges to the…

Anthocyanin content of two hibiscus sabdariffa cultivars grown

African Journals Online (AJOL)

Sukwattanasinit T., Burana-osot J., Sotanaphun. U. 2007. Spectrophotometric Method for. Quantitative Determination of Total. Anthocyanins and Quality Characteristics of Roselle (Hibiscus sabdariffa). Planta Med. 73 (14) : 1517 - 1522. Torres-Morán M.I., Escoto-Delgadillo M., Ron-Parra. J., Parra-Tovar G., Mena-Munguía ...

The Navy Supply Corps Newsletter. Contracting Innovations: Navy Electronic Commerce Online Navy Afloat Purchase Card Program. Volume 62, No. 3.

Science.gov (United States)

1998-06-01

Mike Lyden John Lantelme Andy Mackel Jesus Malgapo Carol Marcinek Greg Martin Michelle McAtee Molly McClellan Jerry McEnerney Laurie McKee...Paul McNeill Walt Melton Rich Mendez Mike Metts Jon Miller Ron Mosley Jim Naber Craig Nostrant NAVSUP USSNORMANDY(CG60) DDRE NORFOLK NPGS

Thank you

CERN Multimedia

GS Department

2009-01-01

We have been deeply touched by the expressions of sympathy and affection from all the friends and colleagues of Ron at CERN. As it is impossible to answer each one, Sophie, Marc and myself would like to express our gratitude to everyone who sent their condolences. Francine Forrest

Kristlased üle maailma sõdivad filmi "Da Vinci kood" vastu / Erkki Bahovski

Index Scriptorium Estoniae

Bahovski, Erkki, 1970-

2006-01-01

17. mail esilinastub Cannes'i filmifestivalil Dan Browni samanimelise menuromaani järgi valminud põnevusfilm "Da Vinci kood" (režissöör Ron Howard, produtsent Brian Greiser). Film on langenud usuorganisatsiooni Opus Dei ägeda kriitika alla. Katoliiklikud ringkonnad on üles kutsunud filmi boikoteerima

77 FR 75425 - Interagency Working Group on Plant Genomics (IWGPG): The National Plant Genome Initiative-What's...

Science.gov (United States)

2012-12-20

... Genome Initiative--What's Next? AGENCY: Office of Science, Office of Biological and Environmental... INFORMATION CONTACT: Dr. Catherine Ronning, U.S. Department of Energy, Office of Science, Office of Biological... 20585-1290. Phone 301-903-9549, fax (301) 903-5051, email: [email protected]science.doe.gov ; Dr. Jane...

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

Science.gov (United States)

Egea, Javier; Fabregat, Isabel; Frapart, Yves M; Ghezzi, Pietro; Görlach, Agnes; Kietzmann, Thomas; Kubaichuk, Kateryna; Knaus, Ulla G; Lopez, Manuela G; Olaso-Gonzalez, Gloria; Petry, Andreas; Schulz, Rainer; Vina, Jose; Winyard, Paul; Abbas, Kahina; Ademowo, Opeyemi S; Afonso, Catarina B; Andreadou, Ioanna; Antelmann, Haike; Antunes, Fernando; Aslan, Mutay; Bachschmid, Markus M; Barbosa, Rui M; Belousov, Vsevolod; Berndt, Carsten; Bernlohr, David; Bertrán, Esther; Bindoli, Alberto; Bottari, Serge P; Brito, Paula M; Carrara, Guia; Casas, Ana I; Chatzi, Afroditi; Chondrogianni, Niki; Conrad, Marcus; Cooke, Marcus S; Costa, João G; Cuadrado, Antonio; My-Chan Dang, Pham; De Smet, Barbara; Debelec-Butuner, Bilge; Dias, Irundika H K; Dunn, Joe Dan; Edson, Amanda J; El Assar, Mariam; El-Benna, Jamel; Ferdinandy, Péter; Fernandes, Ana S; Fladmark, Kari E; Förstermann, Ulrich; Giniatullin, Rashid; Giricz, Zoltán; Görbe, Anikó; Griffiths, Helen; Hampl, Vaclav; Hanf, Alina; Herget, Jan; Hernansanz-Agustín, Pablo; Hillion, Melanie; Huang, Jingjing; Ilikay, Serap; Jansen-Dürr, Pidder; Jaquet, Vincent; Joles, Jaap A; Kalyanaraman, Balaraman; Kaminskyy, Danylo; Karbaschi, Mahsa; Kleanthous, Marina; Klotz, Lars-Oliver; Korac, Bato; Korkmaz, Kemal Sami; Koziel, Rafal; Kračun, Damir; Krause, Karl-Heinz; Křen, Vladimír; Krieg, Thomas; Laranjinha, João; Lazou, Antigone; Li, Huige; Martínez-Ruiz, Antonio; Matsui, Reiko; McBean, Gethin J; Meredith, Stuart P; Messens, Joris; Miguel, Verónica; Mikhed, Yuliya; Milisav, Irina; Milković, Lidija; Miranda-Vizuete, Antonio; Mojović, Miloš; Monsalve, María; Mouthuy, Pierre-Alexis; Mulvey, John; Münzel, Thomas; Muzykantov, Vladimir; Nguyen, Isabel T N; Oelze, Matthias; Oliveira, Nuno G; Palmeira, Carlos M; Papaevgeniou, Nikoletta; Pavićević, Aleksandra; Pedre, Brandán; Peyrot, Fabienne; Phylactides, Marios; Pircalabioru, Gratiela G; Pitt, Andrew R; Poulsen, Henrik E; Prieto, Ignacio; Rigobello, Maria Pia; Robledinos-Antón, Natalia; Rodríguez-Mañas, Leocadio; Rolo, Anabela P; Rousset, Francis; Ruskovska, Tatjana; Saraiva, Nuno; Sasson, Shlomo; Schröder, Katrin; Semen, Khrystyna; Seredenina, Tamara; Shakirzyanova, Anastasia; Smith, Geoffrey L; Soldati, Thierry; Sousa, Bebiana C; Spickett, Corinne M; Stancic, Ana; Stasia, Marie José; Steinbrenner, Holger; Stepanić, Višnja; Steven, Sebastian; Tokatlidis, Kostas; Tuncay, Erkan; Turan, Belma; Ursini, Fulvio; Vacek, Jan; Vajnerova, Olga; Valentová, Kateřina; Van Breusegem, Frank; Varisli, Lokman; Veal, Elizabeth A; Yalçın, A Suha; Yelisyeyeva, Olha; Žarković, Neven; Zatloukalová, Martina; Zielonka, Jacek; Touyz, Rhian M; Papapetropoulos, Andreas; Grune, Tilman; Lamas, Santiago; Schmidt, Harald H H W; Di Lisa, Fabio; Daiber, Andreas

2017-10-01

The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

CHARACTERIZING THE HEAVY ELEMENTS IN GLOBULAR CLUSTER M22 AND AN EMPIRICAL s-PROCESS ABUNDANCE DISTRIBUTION DERIVED FROM THE TWO STELLAR GROUPS

International Nuclear Information System (INIS)

Roederer, I. U.; Marino, A. F.; Sneden, C.

2011-01-01

We present an empirical s-process abundance distribution derived with explicit knowledge of the r-process component in the low-metallicity globular cluster M22. We have obtained high-resolution, high signal-to-noise spectra for six red giants in M22 using the Magellan Inamori Kyocera Echelle spectrograph on the Magellan-Clay Telescope at Las Campanas Observatory. In each star we derive abundances for 44 species of 40 elements, including 24 elements heavier than zinc (Z = 30) produced by neutron-capture reactions. Previous studies determined that three of these stars (the 'r+s group') have an enhancement of s-process material relative to the other three stars (the 'r-only group'). We confirm that the r+s group is moderately enriched in Pb relative to the r-only group. Both groups of stars were born with the same amount of r-process material, but s-process material was also present in the gas from which the r+s group formed. The s-process abundances are inconsistent with predictions for asymptotic giant branch (AGB) stars with M ≤ 3 M ☉ and suggest an origin in more massive AGB stars capable of activating the 22 Ne(α,n) 25 Mg reaction. We calculate the s-process 'residual' by subtracting the r-process pattern in the r-only group from the abundances in the r+s group. In contrast to previous r- and s-process decompositions, this approach makes no assumptions about the r- and s-process distributions in the solar system and provides a unique opportunity to explore s-process yields in a metal-poor environment.

Redox homeostasis and age‐related deficits in neuromuscular integrity and function

Science.gov (United States)

Lightfoot, Adam P.; Earl, Kate E.; Stofanko, Martin; McDonagh, Brian

2017-01-01

Abstract Skeletal muscle is a major site of metabolic activity and is the most abundant tissue in the human body. Age‐related muscle atrophy (sarcopenia) and weakness, characterized by progressive loss of lean muscle mass and function, is a major contributor to morbidity and has a profound effect on the quality of life of older people. With a continuously growing older population (estimated 2 billion of people aged >60 by 2050), demand for medical and social care due to functional deficits, associated with neuromuscular ageing, will inevitably increase. Despite the importance of this ‘epidemic’ problem, the primary biochemical and molecular mechanisms underlying age‐related deficits in neuromuscular integrity and function have not been fully determined. Skeletal muscle generates reactive oxygen and nitrogen species (RONS) from a variety of subcellular sources, and age‐associated oxidative damage has been suggested to be a major factor contributing to the initiation and progression of muscle atrophy inherent with ageing. RONS can modulate a variety of intracellular signal transduction processes, and disruption of these events over time due to altered redox control has been proposed as an underlying mechanism of ageing. The role of oxidants in ageing has been extensively examined in different model organisms that have undergone genetic manipulations with inconsistent findings. Transgenic and knockout rodent studies have provided insight into the function of RONS regulatory systems in neuromuscular ageing. This review summarizes almost 30 years of research in the field of redox homeostasis and muscle ageing, providing a detailed discussion of the experimental approaches that have been undertaken in murine models to examine the role of redox regulation in age‐related muscle atrophy and weakness. PMID:28744984

2345-IJBCS-Article-Yapo Magloire

African Journals Online (AJOL)

hp

Chardonnet P, Fritz H, Zorzi N, Féron E. 1995. Current importance of traditional hunting and major constrasts in wild meat consumption in sub-saharan Africa. In Integrating People and Wildlife for a. Sustainable Future, Bissonette JA,. Kraussman PR (eds). The Wildlife. Society : Bethesda, USA ; 304-307. Fantodji A, Mensah ...

Ballistic Missile Defense System (BMDS) Programmatic Environmental Impact Statement

Science.gov (United States)

2007-01-01

8 Ms. Marti Townsend B-294 9 Ms. Julia Estrella B-301 10 Mr. Ron...you. 8 (Applause.) 9 MR. BONNER: Thank you. 10 Will Julia Estrella come up...11 JULIA ESTRELLA : Good evening. My name is 12 Julia Estrella and I serve on the National Committee 13 of the

The scyllarid lobsters (Crustacea: Decapoda: Palinuridea) collected by F. Peron and C.A. Lesueur during the 1800-1804 expedition to Australia

NARCIS (Netherlands)

Holthuis, L.B.

1996-01-01

The original figures of Scyllaridae by Lesueur and manuscript descriptions and notes by Péron, made during the 1800-1804 French Expedition to Australia, are now kept in the Museum d'Histoire Naturelle du Havre, and shed new light on the identity, type locality and whereabouts of these species. The

Fulltext PDF

Indian Academy of Sciences (India)

IAS Admin

privileges of being an editor of this journal is a preview of some utterly fascinating science expounded by someone who under- stands it. Neuroscience is growing by leaps and bounds, and the experiments described reveal a remarkable architecture of neu- rons and their interconnections and how they underlie one of our.

Relational Inquiries and the Research Interview: Mentoring Future Researchers

Science.gov (United States)

Hoskins, Marie L.; White, Jennifer

2013-01-01

In this article we describe some of the challenges and constraints that students face when they engage in qualitative research interviews. We borrow extensively from Ron Pelias' in-depth description of "leaning in" during everyday life encounters. Although he refers to other kinds of relationships, we believe that the similarities…

Cryptanalysis of MD2

DEFF Research Database (Denmark)

Knudsen, Lars Ramkilde; Mathiassen, John Erik; Muller, Frédéric

2010-01-01

This paper considers the hash function MD2 which was developed by Ron Rivest in 1989. Despite its age, MD2 has withstood cryptanalytic attacks until recently. This paper contains the state-of-the-art cryptanalytic results on MD2, in particular collision and preimage attacks on the full hash...

29 CFR 1952.172 - Level of Federal enforcement.

Science.gov (United States)

2010-07-01

..., and Ron Rinaldi, Director, California Department of Industrial Relations, effective October 5, 1989... access of the shore). (iii) All afloat marine ship building and repair from the foot of the gangway. (iv) All ship building and repair in graving docks or dry docks. (v) All ship repairing done in marine...

Incidencia de la sífilis durante el embarazo

OpenAIRE

Herrera Gómez, Vivian; Rodríguez Domínguez, Lourdes; Febles Tardío, Luis; Gómez Cuervo, Julia

1997-01-01

Se realiza un estudio descriptivo, retrospectivo en el Departamento de Enfermedades de Transmisión Sexual del Policlínico Docente "Nguyen Van Troi" en el trienio 1993 al 1995, con el objetivo de disminuir la morbilidad y la mortalidad por enfermedades de transmisión sexual en las gestantes. Se revisaron las encuestas epidemiológicas realizadas a todas las embarazadas con serologías positivas por el Departamento de Enfermedades de Transmisión Sexual y de cada una de ellas se extrajeron las var...

Effect of a Hypocretin/Orexin Antagonist on Neurocognitive Performance

Science.gov (United States)

2015-11-01

release in freely-moving rat. Location: Hall A-C Presentation time: Tuesday , Nov 15, 2011, 1:00 PM - 2:00 PM Authors: *J. VAZQUEZ, A. NGUYEN, T. KILDUFF...induces sleep in rats but does not impair spatial reference memory performance during wake Location: Hall A-C Presentation time: Tuesday , Nov 15, 2011, 2...of a platform in a spatial reference memory task ( Morris Water Maze). Next day, they were dosed with either ALM (100 mg/kg i.p.), ZOL (30 mg/kg i.p

The Characterization of Material Properties and Structural Dynamics of the Manduca Sexta Forewing for Application to Flapping Wing Micro Air Vehicle Design

Science.gov (United States)

2012-09-13

done by using a Trek Inc. Model PZD700 M/S high voltage piezo amplifier that is capable of generating ±700V at ± 200 mA. This amplifier is also...Actuator”. NASA ICASE Report, 8, 2000. 39. Karpelson, M., G.Y. Wei, and R.J. Wood. “A Review of Actuation and Power Electronics Options for Flapping-Wing...Mechanics of Laminated Composite Plates. NASA , 1994. Reference Publication 1351. 60. Nguyen, Q.V., H.C. Park, N.S. Goo, and D. Byun. “Aerodynamic force

Worlds within Worlds: Audiences, Jargon, and North American Comics Discourse

Directory of Open Access Journals (Sweden)

Craig Fischer

2010-09-01

Full Text Available Let me begin by describing four recent acts of comics criticism, all connected to each other like dominoes falling: The first act: In 2007, the University Press of Mississippi published an English-language translation of Thierry Groensteen’s The System of Comics (Système de la bande dessinée, 1999. In their foreword to System, translators Bart Beaty and Nick Nguyen anticipate obstacles to the American reception of Groensteen’s ideas, arguing that American scholars are unfamiliar with the “do...

Musiclub

CERN Document Server

Musiclub

2016-01-01

On January 28th, theremin virtuoso Dorit Chrysler came to visit CERN, and played one of her songs, "Avalanche", in the Synchrocyclotron hall. Helped by the media service, the MusiClub produced a short clip of the performance. "Dorit Chrysler with the filming team Ron Suykerbuyk, Django Manglunki and Jacques-Hervé Fichet"

Kuldmehikeste nominendid tänavu silmi ei pimesta / Margit Tõnson

Index Scriptorium Estoniae

Tõnson, Margit, 1978-

2009-01-01

Lühiarvustused filmidele, mis kandideerivad Oscarile : Gus Van Santi "Milk", Sam Mendes'i "Mässajate tänav", Woody Alleni "Vicky Cristina Barcelona", Danny Boyle'i "Slummi miljonär", Clint Eastwoodi "Vahetus", Darren Aronofsky "Maadleja", David Fincheri "Benjamin Buttoni uskumatu elu". Andris Feldmanis lisab : Ron Howardi "Frost/Nixon", Stephen Daldry "Ettelugeja"

78 FR 24238 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

Science.gov (United States)

2013-04-24

.... Applicant: Ron Naveen, Oceanites, Inc., P.O. Box 15259, Chevy Chase, MD 20825. Activity for Which Permit Is...-Rothera Point, ASPA 132-Potter Peninsula, ASPA 133-Harmony Point, ASPA 134-Cierva Point, ASPA 139-Biscoe... Admiralty Bay, ASPA 129-Rothera Point, ASPA 132-Potter Peninsula, ASPA 133-Harmony Point, ASPA 134-Cierva...

Inde | Page 123 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Early in 2006, Canadian historians Ron Harpelle of Lakehead University and Bruce Muirhead of the University of Waterloo began work on a book-length intellectual history of IDRC, and on related materials including a website and a documentary film series. As of summer 2008, this ambitious project is moving forward on ...

Inde | Page 91 | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Early in 2006, Canadian historians Ron Harpelle of Lakehead University and Bruce Muirhead of the University of Waterloo began work on a book-length intellectual history of IDRC, and on related materials including a website and a documentary film series. As of summer 2008, this ambitious project is moving forward on ...

Author Details

African Journals Online (AJOL)

van der Watt, Ronél. Vol 26, No 3 (2014) - Articles Clinical Perspective Attachment, parenting styles and bullying during pubertal years. Abstract · Vol 29, No 3 (2017) - Articles The psychosocial themes of children with a congenital heart defect. Abstract. ISSN: 1728-0591. AJOL African Journals Online. HOW TO USE AJOL.

CERN - better than science fiction!

CERN Document Server

2007-01-01

From left to right: Allan Cameron (Production Designer), Sam Breckham (Location Manager), James Gillies (Head of Communication at CERN), Jacques Fichet (from the CERN audiovisual service), Rolf Landua (former spokesman of the ATHENA antihydrogen experiment at CERN and Head of CERN's Education Group), Ron Howard, and Renilde Vanden Broeck (CERN press officer).

Melatonin as a modulator of the gastrointestinal function of the rat

Czech Academy of Sciences Publication Activity Database

Mrnka, Libor; Soták, Matúš; Pácha, Jiří

2005-01-01

Roč. 61, č. 4 (2005), s. 602-602 ISSN 1138-7548. [European Intestinal Transport Group Meeting /20./. 24.09.2005-27.09.2005, Oléron] R&D Projects: GA ČR(CZ) GP305/03/D140 Keywords : melatonin * gastrointestinal tract * short-circuit current * melatonin receptor Subject RIV: ED - Physiology

78 FR 11886 - Agency Forms Undergoing Paperwork Reduction Act Review

Science.gov (United States)

2013-02-20

... the evaluation, a standard model of TDV prevention (Safe Dates administered in 8th grade) will be compared to a comprehensive model (programs administered in 6th, 7th, and 8th grade as well as parent.... Dated: February 12, 2013. Ron A. Otten, Director, Office of Scientific Integrity (OSI), Office of the...

Climate-Conflict Research: Some Reflections on the Way Forward

Science.gov (United States)

2015-02-18

T. The evolution of environment-conflict research: toward a livelihood framework. Global Envi- ron Polit 2012, 12:78–100. 7. Gemenne F, Barnett J...Levin SA. Trading-off fish biodiversity , food security, and hydropower in theMekong River Basin. Proc Natl Acad Sci USA 2012, 109:5609–5614. 52. Tol

From Seatwork to Feetwork: Engaging Students in Their Own Learning

Science.gov (United States)

Nash, Ron

2011-01-01

How do you teach students to communicate, collaborate, and solve problems? In his engaging style, Ron Nash shows teachers how to create a student-centered environment that transforms learners from passive attendees into active participants and leaders in the classroom. Building on the foundation of his prior works on active learning, he combines…

See film on saatanast! / Jaanus Noormets

Index Scriptorium Estoniae

Noormets, Jaanus

2009-01-01

Režissöör Ron Howardi filmist "Inglid ja deemonid", mis on samanimelise Dan Browni raamatu ekraniseering, USA 2009. Lisaks on ära toodud lühiandmed 4 filmi kohta, mis on ärritanud usuinimesi : "Kristuse viimane kiusatus" (1988), "Dogma" (1999), "Kristuse kannatused" (2004) ja "Brokebacki mägi" (2005)

Submarine Warfare in the 20th & 21st Centuries: A Bibliography

Science.gov (United States)

2003-12-01

energy requirements and strategic metals and for over 70 percent of its food . Despite the importance of the sealanes to Japanese security, the Japanese...l’américain par Marianne Véron avec la collab. de Jean Sabbagh]. Paris: Albin michel, 1986. 485 p. Franch translation of The Hunt for Red October

Disainisurf : auhinnad ja ökodisain / Aleksander Tsapov

Index Scriptorium Estoniae

Tsapov, Aleksander

2008-01-01

Alates 2008. aastast hakkab Londoni Disainimuuseum auhindama seitsmes erinevas valdkonnas viimase 12 kuu silmapaistvamaid disainiobjekte. Tootedisaini- ja mööblikategooria nominente: "Sketch Furniture" (disainigrupp Front, Rootsi), valgusti "Pizzakobra" (Ron Arad), laualamp "Fifty" (Anthony Dickens), valgusti "Mayhuana" (Toyo Ito), moodulriiulid "Make / Shift" (Peter Marigold). Arhitektuuriauhinna nominentide hulgas on KOKO Arhitektide projekteeritud Fahle maja

FSILP: fuzzy-stochastic-interval linear programming for supporting municipal solid waste management.

Science.gov (United States)

Li, Pu; Chen, Bing

2011-04-01

Although many studies on municipal solid waste management (MSW management) were conducted under uncertain conditions of fuzzy, stochastic, and interval coexistence, the solution to the conventional linear programming problems of integrating fuzzy method with the other two was inefficient. In this study, a fuzzy-stochastic-interval linear programming (FSILP) method is developed by integrating Nguyen's method with conventional linear programming for supporting municipal solid waste management. The Nguyen's method was used to convert the fuzzy and fuzzy-stochastic linear programming problems into the conventional linear programs, by measuring the attainment values of fuzzy numbers and/or fuzzy random variables, as well as superiority and inferiority between triangular fuzzy numbers/triangular fuzzy-stochastic variables. The developed method can effectively tackle uncertainties described in terms of probability density functions, fuzzy membership functions, and discrete intervals. Moreover, the method can also improve upon the conventional interval fuzzy programming and two-stage stochastic programming approaches, with advantageous capabilities that are easily achieved with fewer constraints and significantly reduces consumption time. The developed model was applied to a case study of municipal solid waste management system in a city. The results indicated that reasonable solutions had been generated. The solution can help quantify the relationship between the change of system cost and the uncertainties, which could support further analysis of tradeoffs between the waste management cost and the system failure risk. Copyright © 2010 Elsevier Ltd. All rights reserved.

Optimization of the octane response of gasoline/ethanol blends

KAUST Repository

Badra, Jihad; AlRamadan, Abdullah S.; Sarathy, Mani

2017-01-01

The octane responses of gasoline/ethanol mixtures are not well understood because of the unidentified intermolecular interactions in such blends. In general, when ethanol is blended with gasoline, the Research Octane Number (RON) and the Motor Octane Number (MON) non-linearly increase or decrease, and the non-linearity is determined by the composition of the base gasoline and the amount of added ethanol. The complexity of commercial gasolines, comprising of hundreds of different components, makes it challenging to understand ethanol-gasoline synergistic/antagonistic blending effects. Understanding ethanol blending effects with simpler gasoline surrogates is critical to acquire knowledge about ethanol blending with complex multi-component gasoline fuels. In this study, the octane numbers (ON) of ethanol blends with five relevant gasoline surrogate molecules were measured. The molecules investigated in this study include: n-pentane, iso-pentane, 1,2,4-trimethylbenzene, cyclopentane and 1-hexene. These new measurements along with the available data of n-heptane, iso-octane, toluene, various primary reference fuels (PRF) and toluene primary reference fuels (TPRF) with ethanol are used to develop a blending rule for the octane response (RON and MON) of multi-component blends with ethanol. In addition, new ON data are collected for six Fuels for Advanced Combustion Engine (FACE) with ethanol. The relatively simple volume based model successfully predicts the octane numbers (ON) of the various ethanol/PRF and ethanol/TPRF blends with the majority of predictions being within the ASTM D2699 (RON) and D2700 (MON) reproducibility limits. The model is also successfully validated against the ON of the FACE gasolines blended with ethanol with the majority of predictions being within the reproducibility limits. Finally, insights into the possible causes of the synergistic and antagonistic effects of different molecules with ethanol are provided.

Production and correlation of reactive oxygen and nitrogen species in gas- and liquid-phase generated by helium plasma jets under different pulse widths

Science.gov (United States)

Liu, Zhijie; Zhou, Chunxi; Liu, Dingxin; Xu, Dehui; Xia, Wenjie; Cui, Qingjie; Wang, Bingchuan; Kong, Michael G.

2018-01-01

In this paper, we present the effects of the pulse width (PW) on the plasma jet's discharge characteristics, particularly focusing on the production and correlation of the reactive oxygen and nitrogen species (RONS) in gas- and liquid-phase. It is found that the length of plasma jet plume first increases before the PW of 10 μs, then gradually decreases and finally almost remains unchanged beyond 150 μs. The plasma bullet disappears after the falling edge of the voltage pulse at low PW, while it terminates far ahead of the falling edge of voltage pulse at high PW. This is mainly attributed to accumulation of space charges that lead to weakening of the reduced electric field with an increase of PW from low to high. More important, it is found that the excited reactive species, the positive and negative ions from plasma jet, and the concentrations of NO2- and NO3- in deionized water exposed to plasma jet also display the first increasing and then decreasing change trend with increase of PW, while the concentration of H2O2 in water almost displays the linearly increasing trend. This mainly results from the formation of the H3O+ and HO2-, as well as their ion water clusters that can produce more OH radicals to be converted into H2O2, while the NO2- and NO3- in gas phase can transport into water and exist most stably in water. The water cluster formation at gas-liquid interface is an important key process that can affect the chemical nature and dose of aqueous RONS in water; this is beneficial for understanding how the RONS are formed in liquid-phase.

Mixed butanols addition to gasoline surrogates: Shock tube ignition delay time measurements and chemical kinetic modeling

KAUST Repository

AlRamadan, Abdullah S.

2015-10-01

The demand for fuels with high anti-knock quality has historically been rising, and will continue to increase with the development of downsized and turbocharged spark-ignition engines. Butanol isomers, such as 2-butanol and tert-butanol, have high octane ratings (RON of 105 and 107, respectively), and thus mixed butanols (68.8% by volume of 2-butanol and 31.2% by volume of tert-butanol) can be added to the conventional petroleum-derived gasoline fuels to improve octane performance. In the present work, the effect of mixed butanols addition to gasoline surrogates has been investigated in a high-pressure shock tube facility. The ignition delay times of mixed butanols stoichiometric mixtures were measured at 20 and 40bar over a temperature range of 800-1200K. Next, 10vol% and 20vol% of mixed butanols (MB) were blended with two different toluene/n-heptane/iso-octane (TPRF) fuel blends having octane ratings of RON 90/MON 81.7 and RON 84.6/MON 79.3. These MB/TPRF mixtures were investigated in the shock tube conditions similar to those mentioned above. A chemical kinetic model was developed to simulate the low- and high-temperature oxidation of mixed butanols and MB/TPRF blends. The proposed model is in good agreement with the experimental data with some deviations at low temperatures. The effect of mixed butanols addition to TPRFs is marginal when examining the ignition delay times at high temperatures. However, when extended to lower temperatures (T < 850K), the model shows that the mixed butanols addition to TPRFs causes the ignition delay times to increase and hence behaves like an octane booster at engine-like conditions. © 2015 The Combustion Institute.

Characterizing the Heavy Elements in Globular Cluster M22 and an Empirical s-process Abundance Distribution Derived from the Two Stellar Groups

Science.gov (United States)

Roederer, I. U.; Marino, A. F.; Sneden, C.

2011-11-01

We present an empirical s-process abundance distribution derived with explicit knowledge of the r-process component in the low-metallicity globular cluster M22. We have obtained high-resolution, high signal-to-noise spectra for six red giants in M22 using the Magellan Inamori Kyocera Echelle spectrograph on the Magellan-Clay Telescope at Las Campanas Observatory. In each star we derive abundances for 44 species of 40 elements, including 24 elements heavier than zinc (Z = 30) produced by neutron-capture reactions. Previous studies determined that three of these stars (the "r+s group") have an enhancement of s-process material relative to the other three stars (the "r-only group"). We confirm that the r+s group is moderately enriched in Pb relative to the r-only group. Both groups of stars were born with the same amount of r-process material, but s-process material was also present in the gas from which the r+s group formed. The s-process abundances are inconsistent with predictions for asymptotic giant branch (AGB) stars with M <= 3 M ⊙ and suggest an origin in more massive AGB stars capable of activating the 22Ne(α,n)25Mg reaction. We calculate the s-process "residual" by subtracting the r-process pattern in the r-only group from the abundances in the r+s group. In contrast to previous r- and s-process decompositions, this approach makes no assumptions about the r- and s-process distributions in the solar system and provides a unique opportunity to explore s-process yields in a metal-poor environment. This paper includes data gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile.

Optimization of the octane response of gasoline/ethanol blends

KAUST Repository

Badra, Jihad

2017-07-04

The octane responses of gasoline/ethanol mixtures are not well understood because of the unidentified intermolecular interactions in such blends. In general, when ethanol is blended with gasoline, the Research Octane Number (RON) and the Motor Octane Number (MON) non-linearly increase or decrease, and the non-linearity is determined by the composition of the base gasoline and the amount of added ethanol. The complexity of commercial gasolines, comprising of hundreds of different components, makes it challenging to understand ethanol-gasoline synergistic/antagonistic blending effects. Understanding ethanol blending effects with simpler gasoline surrogates is critical to acquire knowledge about ethanol blending with complex multi-component gasoline fuels. In this study, the octane numbers (ON) of ethanol blends with five relevant gasoline surrogate molecules were measured. The molecules investigated in this study include: n-pentane, iso-pentane, 1,2,4-trimethylbenzene, cyclopentane and 1-hexene. These new measurements along with the available data of n-heptane, iso-octane, toluene, various primary reference fuels (PRF) and toluene primary reference fuels (TPRF) with ethanol are used to develop a blending rule for the octane response (RON and MON) of multi-component blends with ethanol. In addition, new ON data are collected for six Fuels for Advanced Combustion Engine (FACE) with ethanol. The relatively simple volume based model successfully predicts the octane numbers (ON) of the various ethanol/PRF and ethanol/TPRF blends with the majority of predictions being within the ASTM D2699 (RON) and D2700 (MON) reproducibility limits. The model is also successfully validated against the ON of the FACE gasolines blended with ethanol with the majority of predictions being within the reproducibility limits. Finally, insights into the possible causes of the synergistic and antagonistic effects of different molecules with ethanol are provided.

An Arakelov-theoretic approach to naïve heights on hyperelliptic Jacobians

NARCIS (Netherlands)

Holmes, David S T

2014-01-01

We use Arakelov theory to define a height on divisors of degree zero on a hyperelliptic curve over a global field, and show that this height has computably bounded difference from the Néron-Tate height of the corresponding point on the Jacobian. We give an algorithm to compute the set of points of

Conducting Qualitative Data Analysis: Managing Dynamic Tensions within

Science.gov (United States)

Chenail, Ronald J.

2012-01-01

In the third of a series of "how-to" essays on conducting qualitative data analysis, Ron Chenail examines the dynamic tensions within the process of qualitative data analysis that qualitative researchers must manage in order to produce credible and creative results. These tensions include (a) the qualities of the data and the qualitative data…

Toponyms for centers of endemism in Madagascar | Wilmé ...

African Journals Online (AJOL)

Ici, nous considérons ces dispositifs géographiques en soulignant leur importance biologique et socio-culturelle. Dans un premier temps, nous expliquons la toponymie ou l'éponymie des grands fleuves des bassins refuges et de dispersion, à savoir les bassins de la Bemarivo, de l'Antainambalana, du Mangoro, de la ...

Conducting Qualitative Data Analysis: Qualitative Data Analysis as a Metaphoric Process

Science.gov (United States)

Chenail, Ronald J.

2012-01-01

In the second of a series of "how-to" essays on conducting qualitative data analysis, Ron Chenail argues the process can best be understood as a metaphoric process. From this orientation he suggests researchers follow Kenneth Burke's notion of metaphor and see qualitative data analysis as the analyst systematically considering the "this-ness" of…

Comment le CERN profite du star-system hollywoodien

CERN Document Server

Comby, Geneviève

2009-01-01

The very serious european center for nuclear research did not hesitate to team up with the kings of the entertainement. Tom Hanks and Ron Howard in head, on the occasion of the release of the american spectacular "Angels and Demons" in which a bomb of antimatter stolen at CERN threatens the Vatican. (2 pages)

Suitability of a lime source high in manganese as a feed ingredient ...

African Journals Online (AJOL)

Die Ouplaaskalk is teen 1% en 4% in 'n vetmestingsrantsoen vir lammers geplaas en vergelyk met 'n ander b'ron van kalk (Kulukalk; 45 mg Mn/kg), ingesluit teen dieselfde vlakke. Lammers in die vier behandelings is vir 69 dae individueel gevoer en daarna geslag. Die finale rantsoene het geen minerale teen toksiese ...

Trend on teada, või kuidas? / Tõnu Kaalep

Index Scriptorium Estoniae

Kaalep, Tõnu, 1966-

1999-01-01

Sisustusmess "Habitare'99" Helsingis. Praegune sisekujundusmood. Eestist olid messil ZiZi kodutekstiilid, Steel Line'i toodetud Tarmo Luisu lambid, kataloogi andmetel firmad Majestic ja Päikesedekoori OÜ. Noorte mööblidisainivõistluse võitsid Touko Korhonen ja Simo Puntila. Hindaja inglise disainiprofessor Ron Arad. Üks Soome Sisearhitektide Liidu kahest aastapreemiast Ben af Schultenile

Buckling behavior of origami unit cell facets under compressive loads

Science.gov (United States)

Kshad, Mohamed Ali Emhmed; Naguib, Hani E.

2018-03-01

Origami structures as cores for sandwich structures are designed to withstand the compressive loads and to dissipate compressive energy. The deformation of the origami panels and the unit cell facets are the primary factors behind the compressive energy dissipation in origami structures. During the loading stage, the origami structures deform through the folding and unfolding process of the unit cell facets, and also through the plastic deformation of the facets. This work presents a numerical study of the buckling behavior of different origami unit cell elements under compressive loading. The studied origami configurations were Miura and Ron-Resch-like origami structures. Finite element package was used to model the origami structures. The study investigated the buckling behavior of the unit cell facets of two types of origami structures Miura origami and Ron-Resch-Like origami structures. The simulation was conducted using ANSYS finite element software, in which the model of the unit cell represented by shell elements, and the eigenvalues buckling solver was used to predict the theoretical buckling of the unit cell elements.

Knock Prediction Using a Simple Model for Ignition Delay

KAUST Repository

Kalghatgi, Gautam

2016-04-05

An earlier paper has shown the ability to predict the phasing of knock onset in a gasoline PFI engine using a simple ignition delay equation for an appropriate surrogate fuel made up of toluene and PRF (TPRF). The applicability of this approach is confirmed in this paper in a different engine using five different fuels of differing RON, sensitivity, and composition - including ethanol blends. An Arrhenius type equation with a pressure correction for ignition delay can be found from interpolation of previously published data for any gasoline if its RON and sensitivity are known. Then, if the pressure and temperature in the unburned gas can be estimated or measured, the Livengood-Wu integral can be estimated as a function of crank angle to predict the occurrence of knock. Experiments in a single cylinder DISI engine over a wide operating range confirm that this simple approach can predict knock very accurately. The data presented should enable engineers to study knock or other auto-ignition phenomena e.g. in premixed compression ignition (PCI) engines without explicit chemical kinetic calculations. © Copyright 2016 SAE International.

Bipartite Anterior Extraperitoneal Teratoma: Evidence for the Embryological Origins of Teratomas?

Directory of Open Access Journals (Sweden)

D. J. B. Keene

2011-01-01

Full Text Available Teratomas are thought to arise from totipotent primordial germ cells (PGCs Dehner (1983 which may miss their target destination Moore and Persaud (1984. Teratomas can occur anywhere from the brain to the coccygeal area but are usually in the midline close to the embryological position of the gonadal ridges Bale (1984, Nguyen and Laberge (2000. We report a case of a bipartite anterior extraperitoneal teratoma. This is an unusual position for a teratoma, but one which may support the “missed target” theory of embryology.

Pathogenesis of Septic Acute Lung Injury and Strategies for Immuno-Pharmacological Therapy.

Science.gov (United States)

1996-10-01

J Cell Biol 120:1227-1235. 90. Lasky, L. A., M. S. Singer, D. Dowbenko, Y. Imai, W. J. Henzel, C. Grimley, C. Fennie , N. Gillett, S. R. Watson, and...Rats. J. Immunol 152:832-840. 102. Lasky, L. A., M. S. Singer, T. A. Yednock, D. Dowbenko, C. Fennie , H. Rodriguez, T. Nguyen, S. Stachel, and S. D...1132-1135. 105. Foxall, C. R., S. R. Watson, C. Fennie , L. A. Lasky, M. Kiso, A. Hasegawa, D. Asa, and B. Brandley. 1992. The three members of the

Design and analysis of spiral inductors

CERN Document Server

Haobijam, Genemala

2013-01-01

The book addresses the critical challenges faced by the ever-expanding wireless communication market and the increasing frequency of operation due to continuous innovation of high performance integrated passive devices. The challenges like low quality factor, design complexity, manufacturability, processing cost, etc., are studied with examples and specifics. Silicon on-chip inductor was first reported in 1990 by Nguyen and Meyer in a 0.8 µm silicon bipolar complementary metal oxide semiconductor technology (BiCMOS). Since then, there has been an enormous progress in the research on the perfo

Improving GC-PPC-SAFT equation of state for LLE of hydrocarbons and oxygenated compounds with water

DEFF Research Database (Denmark)

Nguyen, Thanh-Binh; Jean-Charles, De Hemptinne; Creton, Benoit

2014-01-01

, uαβ, and wαβ are fitted on mutual solubilities of water and organic compounds. The regressed values which are obtained for each chemical family, are subsequently used for predicting infinite dilution activity coefficient in water and n-octanol/water partition coefficient.In general, the results...... obtained are very much improved compared to the predictive approach discussed previously [Nguyen et al. Ind. Eng. Chem. Res. 52 (2013) 7014-7029]. The global deviation values on the decimal log scale for infinite dilution activity coefficient in water, water solubility and n-octanol/water partition...

The Battle of Midway Including the Aleutian Phase, June 3 to June 14, 1942. Strategical and Tactical Analysis

Science.gov (United States)

1948-01-01

prosumably to assist in ideutitoatirn. At 1430 the 9trike Lnuder of this 3.1? ;roap’ reported sithtlng TF 18. He rrooeeded ornward on oourse 3000 (T) to...on Dutoh Lrbor or Cold Day. *War Diary, lomlatRon 42# May 21th to Ju= 30t%, 1941. solar Diary, Commander NorthWestleaFrontier, June 1042. ***The major

16 septembre 2015 - Signature du livre d'or par S. Exc. Mme Laurin, Ambassadeur de France auprès de l’Office des Nations Unies et des organisations internationales en Suisse avec le Directeur général du CERN R. Heuer, et de la Directrice générale élue 2016-2020 F. Gianotti.

CERN Multimedia

Brice, Maximilien

2015-01-01

Son Excellence Madame Elisabeth Laurin Ambassadeur Représentant permanent de la République française auprès de l’Office des Nations Unies et des organisations internationales en Suisse République française. Sont également présents: E. Göniger Voss, S. Péron, O. Martin, F. Bordry, A-S. Catherin, F. Eder.

Etude sur les sources de la passion du Palatinus

NARCIS (Netherlands)

Maas, Paul Marie

1942-01-01

Notre étude sur la Passion du Palatinus étant terminée, nous voudrions ajouter un aperçu des principaux résultats obtenus. Quelque modestes qu'ils soient, nous espérons que ces résultats pouront contribuer à faire mieux comprendre les rapports obscurs qui existent entre notre Passion et ses sources

Array based Discovery of Aptamer Pairs (Open Access Publisher’s Version)

Science.gov (United States)

2014-12-11

Array-based Discovery of Aptamer Pairs Minseon Cho,†,‡ Seung Soo Oh,‡ Jeff Nie,§ Ron Stewart,§ Monte J. Radeke,⊥ Michael Eisenstein ,†,‡ Peter J...ac504076k | Anal. Chem. 2015, 87, 821−828827 (24) Cho, M.; Oh, S. S.; Nie, J.; Stewart, R.; Eisenstein , M.; Chambers, J.; Marth, J. D.; Walker, F

LALIGENS

African Journals Online (AJOL)

ESSOH GRACE

10 mai 2015 ... peu longues et quelquefois sans subordination. Considérons cependant deux des romans d'Ahmadou Kourouma dont ANPO et EALVDBS. Dorénavant les abréviations ANPO et EALVDBS feront références respectivement aux romans Allah n'est pas obligé et En attendant les votes des bêtes sauvages.

The experts from the Review of LHC Superconducting Cables and Magnet Production, accompanied by the committee's secretary and the Head of the Magnets and Superconductors Group.

CERN Document Server

2004-01-01

From left to right: Ron Scanlan (Lawrence Berkeley National Laboratory, US), Taka Shintomi (KEK Laboratory, Japan), Claudine Bosteels (Secretary of the Review, AT-MAS Group, CERN), Lucio Rossi (Head of AT-MAS Group, CERN), Ettore Salpietro (EDFA-Iter project), Bruce Strauss (US Department of Energy, Chairman of the committee), and Pierre Vedrine (CEA-DAPNIA-SACM, France).

Multi-dimensional free-electron laser simulation codes: a comparison study

CERN Document Server

Biedron, S G; Dejus, Roger J; Faatz, B; Freund, H P; Milton, S V; Nuhn, H D; Reiche, S

2000-01-01

A self-amplified spontaneous emission (SASE) free-electron laser (FEL) is under construction at the Advanced Photon Source (APS). Five FEL simulation codes were used in the design phase: GENESIS, GINGER, MEDUSA, RON, and TDA3D. Initial comparisons between each of these independent formulations show good agreement for the parameters of the APS SASE FEL.

Multi-dimensional free-electron laser simulation codes: a comparison study

International Nuclear Information System (INIS)

Biedron, S. G.; Chae, Y. C.; Dejus, R. J.; Faatz, B.; Freund, H. P.; Milton, S. V.; Nuhn, H.-D.; Reiche, S.

1999-01-01

A self-amplified spontaneous emission (SASE) free-electron laser (FEL) is under construction at the Advanced Photon Source (APS). Five FEL simulation codes were used in the design phase: GENESIS, GINGER, MEDUSA, RON, and TDA3D. Initial comparisons between each of these independent formulations show good agreement for the parameters of the APS SASE FEL

The APS SASE FEL: modeling and code comparison

International Nuclear Information System (INIS)

Biedron, S. G.

1999-01-01

A self-amplified spontaneous emission (SASE) free-electron laser (FEL) is under construction at the Advanced Photon Source (APS). Five FEL simulation codes were used in the design phase: GENESIS, GINGER, MEDUSA, RON, and TDA3D. Initial comparisons between each of these independent formulations show good agreement for the parameters of the APS SASE FEL

Las elecciones de gobernador en Sonora, 1997*

Directory of Open Access Journals (Sweden)

Juan Poom Medina

2003-01-01

Full Text Available El objetivo del presente artículo es analizar el desarrollo y resultados de las elecciones de gobernador re alizadas en Sonora en 1997. Se exponen y analizan las distintas fases que confo rm a ron dicho proceso elector al, tomando como punto de partida la caracterización de las elecciones en México.

A revision of dragon millipedes I: genus Desmoxytes Chamberlin, 1923, with the description of eight new species (Diplopoda, Polydesmida, Paradoxosomatidae

Directory of Open Access Journals (Sweden)

Ruttapon Srisonchai

2018-05-01

Full Text Available The dragon millipede genus Desmoxytes s.l. is split into five genera, based on morphological characters and preliminary molecular phylogenetic analyses. The present article includes a review of Desmoxytes s.s., while future articles will deal with Hylomus Cook and Loomis, 1924 and three new genera which preliminarily are referred to as the ‘acantherpestes’, ‘gigas’, and ‘spiny’ groups. Diagnostic morphological characters of each group are discussed. Hylomus is resurrected as a valid genus and the following 33 species are assigned to it: H. asper (Attems, 1937, comb. n., H. cattienensis (Nguyen, Golovatch & Anichkin, 2005, comb. n., H. cervarius (Attems, 1953, comb. n., H. cornutus (Zhang & Li, 1982, comb. n., H. draco Cook & Loomis, 1924, stat. rev., H. enghoffi (Nguyen, Golovatch & Anichkin, 2005, comb. n., H. eupterygotus (Golovatch, Li, Liu & Geoffroy, 2012, comb. n., H. getuhensis (Liu, Golovatch & Tian, 2014, comb. n., H. grandis (Golovatch, VandenSpiegel & Semenyuk, 2016, comb. n., H. hostilis (Golovatch & Enghoff, 1994, comb. n., H. jeekeli (Golovatch & Enghoff, 1994, comb. n., H. lingulatus (Liu, Golovatch & Tian, 2014, comb. n., H. laticollis (Liu, Golovatch & Tian, 2016, comb. n., H. longispinus (Loksa, 1960, comb. n., H. lui (Golovatch, Li, Liu & Geoffroy, 2012, comb. n., H. minutuberculus (Zhang, 1986, comb. n., H. nodulosus (Liu, Golovatch & Tian, 2014, comb. n., H. parvulus (Liu, Golovatch & Tian, 2014, comb. n., H. phasmoides (Liu, Golovatch & Tian, 2016, comb. n., H. pilosus (Attems, 1937, comb. n., H. proximus (Nguyen, Golovatch & Anichkin, 2005, comb. n., H. rhinoceros (Likhitrakarn, Golovatch & Panha, 2015, comb. n., H. rhinoparvus (Likhitrakarn, Golovatch & Panha, 2015, comb. n., H. scolopendroides (Golovatch, Geoffroy & Mauriès, 2010, comb. n., H. scutigeroides (Golovatch, Geoffroy & Mauriès, 2010, comb. n., H. similis (Liu, Golovatch & Tian, 2016, comb. n., H. simplex (Golovatch, VandenSpiegel & Semenyuk, 2016

Transition to Organic Tea Production in the Thai Nguyen Province, Vietnam: Economic and Environmental Impacts

OpenAIRE

Nghia Dai Tran

2009-01-01

This study from Vietnam shows that a switch from conventional to organic tea productions would bring real environmental, health and economic benefits for the country's farmers and its society as a whole. In particular, the amount of agrochemical residue and waste produced by tea production would be reduced. Farmers would also be able to enjoy a better livelihood as they could command a premium price for their organic tea products. The study therefore recommends that organic tea production is ...

La "main invisible" dans les langues et la confection de dictionnaires ...

African Journals Online (AJOL)

user

conduit à atteindre un objectif qui n'était pas dans leurs intentions, d'autant plus que c'est dans ce cas qu'ils sont ..... colonisation. Nous considérons l'écriture comme "la liste de signes graphiques ..... locuteurs ne parlent pas, et ils veulent faire parler ce que les locuteurs n'ont pas standardisé. .... tue aucun mal. Le signe ...

Sequence Classification: 225448 [

Lifescience Database Archive (English)

Full Text Available genase iron molybdenum cofactor biosinthesis protein, nifK-nitrogenase molibdenum-i...ron protein beta chain, nifB-nitrogenase iron-molibdenum cofactor biosynthesis protein) || http://www.ncbi.nlm.nih.gov/protein/15893551 ... ...Non-TMB Non-TMH Non-TMB Non-TMB Non-TMB Non-TMB >gi|15893551|ref|NP_346900.1| Fusion nifN/K+nifB (nifN-nitro

Detsibill : Meie aja kangelane Maryn E. Coote ning ajakirjandus. White label : Soda Effect - Uus kraam. Kuula / DJ Pickney Tiger

Index Scriptorium Estoniae

DJ Pickney Tiger, pseud., 1970-

2007-01-01

Poplauljast Marju Kuudist. Ansambli Soda Effect heliplaadist. Heliplaatidest: Sentenced "Buried Alive", Depeche Mode"Best of. Volume 1", Moby "Go: The Very Best", Bill Frisell, Ron CArter, Paul Motian "Nonesuch", My Chemical Romance "The Black Parade", Arabanda "Shams", Barbariz "Auh", Demogustico "Demogustico", Tutty Moreno ft. Jouce "Magica", Akon "Konvicted", Union Of Knives "Violence and Birdsong", Snoop Dogg "The Blue Carpet Treatment"

Conducting Qualitative Data Analysis: Reading Line-by-Line, but Analyzing by Meaningful Qualitative Units

Science.gov (United States)

Chenail, Ronald J.

2012-01-01

In the first of a series of "how-to" essays on conducting qualitative data analysis, Ron Chenail points out the challenges of determining units to analyze qualitatively when dealing with text. He acknowledges that although we may read a document word-by-word or line-by-line, we need to adjust our focus when processing the text for purposes of…

Ardeae

NARCIS (Netherlands)

Schlegel, H.

1864-01-01

ARDEA. L’histoire naturelle des hérons a été excessivement embrouillée par certains naturalistes, grâce à l’ignorance des phénomènes que ces oiseaux présentent, à l’amour de la multiplication des espèces, comme à celui de la complication de l’échafaudage des classifications modernes. Pour ne citer

Supplement to a Methodology for Succession Planning for Technical Experts

Energy Technology Data Exchange (ETDEWEB)

Kirk, Bernadette Lugue [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Cain, Ronald A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Agreda, Carla L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2017-11-01

This report complements A Methodology for Succession Planning for Technical Experts (Ron Cain, Shaheen Dewji, Carla Agreda, Bernadette Kirk, July 2017), which describes a draft methodology for identifying and evaluating the loss of key technical skills at nuclear operations facilities. This report targets the methodology for identifying critical skills, and the methodology is tested through interviews with selected subject matter experts.

Downregulation of CD44 reduces doxorubicin resistance of CD44+CD24- breast cancer cells

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Phuc PV

2011-06-01

Full Text Available Pham Van Phuc, Phan Lu Chinh Nhan, Truong Hai Nhung, Nguyen Thanh Tam, Nguyen Minh Hoang, Vuong Gia Tue, Duong Thanh Thuy, Phan Kim NgocLaboratory of Stem Cell Research and Application, University of Science, Vietnam National University, Ho Chi Minh, VietnamBackground: Cells within breast cancer stem cell populations have been confirmed to have a CD44+CD24- phenotype. Strong expression of CD44 plays a critical role in numerous types of human cancers. CD44 is involved in cell differentiation, adhesion, and metastasis of cancer cells.Methods: In this study, we reduced CD44 expression in CD44+CD24- breast cancer stem cells and investigated their sensitivity to an antitumor drug. The CD44+CD24- breast cancer stem cells were isolated from breast tumors; CD44 expression was downregulated with siRNAs followed by treatment with different concentrations of the antitumor drug.Results: The proliferation of CD44 downregulated CD44+CD24- breast cancer stem cells was decreased after drug treatment. We noticed treated cells were more sensitive to doxorubicin, even at low doses, compared with the control groups.Conclusions: It would appear that expression of CD44 is integral among the CD44+CD24- cell population. Reducing the expression level of CD44, combined with doxorubicin treatment, yields promising results for eradicating breast cancer stem cells in vitro. This study opens a new direction in treating breast cancer through gene therapy in conjunction with chemotherapy.Keywords: antitumor drugs, breast cancer stem cells, CD44, CD44+CD24- cells, doxorubicin

Enuresis y Medicina Tradicional

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María Elena Francia Reyes

2003-02-01

Full Text Available La enuresis es la emisión involuntaria de orina que ocurre generalmente en el niño mientras duerme en la noche, aunque también puede ocurrir durante el sueño diurno. Se realizó un estudio descriptivo, retrospectivo, longitudinal con 50 pacientes de la consulta de psiquiatría infantojuvenil del policlínico "Nguyen Van Troi", en el municipio Centro Habana, con diagnóstico de enuresis. Nuestro objetivo fundamental fue demostrar la efectividad de la auriculoterapia y la moxibustión como modalidades de la Medicina Natural y Tradicional en estos pacientes. Se estableció un esquema de puntos a estimular, tanto para la auriculoterapia como para la moxibustión. En los resultados se demuestra que más del 50 % de los pacientes evolucionaron satisfactoriamente con 10 sesiones de tratamiento.Enuresis is the involuntary discharge of urine occurring generally in the child while he/she is sleeping at night, although it may also happen during day sleep. A retrospective longitudinal and descriptive study of 50 patients, diagnosed with enuresis and seen at the infantile-juvenile psychiatry service of "Nguyen Van Troi" polyclinics in Centro Habana municipality, was conducted. Our main objective was to prove the effectiveness of ear acupuncture and moxibustion- modalities of traditional medicine- in these patients. A pattern of points to be stimulated both in ear acupunture and moxibustion was established. The results showed that over 50 % of the patients recovered satisfactorily after ten treatment sessions.

Noncommutative Chern-Connes characters of some noncompact quantum algebras

International Nuclear Information System (INIS)

Do Ngoc Diep; Kuku, Aderemi O.

2001-09-01

We prove in this paper that the periodic cyclic homology of the quantized algebras of functions on coadjoint orbits of connected and simply connected Lie group, are isomorphic to the periodic cyclic homology of the quantized algebras of functions on coadjoint orbits of compact maximal subgroups, without localization. Some noncompact quantum groups and algebras were constructed and their irreducible representations were classified in recent works of Do Ngoc Diep and Nguyen Viet Hai [DH1]-[DH2] by using deformation quantization. In this paper we compute their K-groups, periodic cyclic homology groups and their Chern characters. (author)

K-theory and periodic cyclic homology of some noncompact quantum algebras

International Nuclear Information System (INIS)

Do Ngoc Diep; Kuku, Aderemi O.

2003-07-01

We prove in this paper that the periodic cyclic homology of the quantized algebras of functions on coadjoint orbits of connected and simply connected Lie group, are isomorphic to the periodic cyclic homology of the quantized algebras of functions on coadjoint orbits of compact maximal subgroups, without localization. Some noncompact quantum groups and algebras were constructed and their irreducible representations were classified in recent works of Do Ngoc Diep and Nguyen Viet Hai [DH1]-[DH2] and Do Due Hanh [DD] by using deformation quantization. In this paper we compute their K-groups, periodic cyclic homology groups and their Chern characters. (author)

The Falls City Engineers: A History of the Louisville District U.S. Army Corps of Engineers 1984-2004

Science.gov (United States)

2008-01-01

been undertaken nor completed. Contract administrators Jon Fleshman and Vanessa Whitworth together with Carol Labashosky and Todd Hornback of the...Frick, Doug Shelton, Lee Anne Devine, Robert Willis, Eugene Dowell, Charles Decker, Robert Van Hoff, Steve Rager, and Ron Waller, plus the crews at...and able.28 Edward Hoagland, the resource manager, handled the transition. He arranged the transfer of personnel and projects from the Mobile

Ship and Shoot

Science.gov (United States)

Woods, Ron

2012-01-01

Ron Woods shared incredibly valuable insights gained during his 28 years at the Kennedy Space Center (KSC) packaging Flight Crew Equipment for shuttle and ISS missions. In particular, Woods shared anecdotes and photos from various processing events. The moral of these stories and the main focus of this discussion were the additional processing efforts and effects related to a "ship-and-shoot" philosophy toward flight hardware.

Shale Gas Development Requires Bipartisan Path Forward, U.S. Senator Wyden Urges

Science.gov (United States)

Showstack, Randy

2013-08-01

"How do we work in a bipartisan way to lock in the lead that the country has with respect to natural gas and win all the gold that we want in the economic Olympic games?" That is a question U.S. Sen. Ron Wyden (D-Oreg.) posed during his keynote address at a 25 July forum in Washington, D. C., on the future of shale gas development.

An Investigation of Methods for Reducing Sampling Error in Certain IRT (Item Response Theory) Procedures.

Science.gov (United States)

1983-08-01

Standard Errors for B1 Bell-shaped distribution Rectangular Item b Bn-45 n=90 n-45 n=45 -No. i i N-1500 N=1500 N-6000 N=1500 1 -2.01 -1.75 0.516 0.466...34th Streets Lawrence, KS 66045 Baltimore, MD 21218 ENIC Facility-Acquisitions 1 Dr. Ron Hambleton 4t33 Rugby Avenue School of Education Lcthesda, !ID

Ibis

NARCIS (Netherlands)

Schlegel, H.

1864-01-01

Ces oiseaux se rapprochent plutôt des Hérons que des Cicognes, et ne rapellent les Courlis que par la forme générale de leur bec. Ils se propagent en société, construisent leur nids sur des arbres ou arbustes au milieu des marais ou lieux inondés, et pondent des oeufs d’une teinte claire et

Macrophage-stimulating protein attenuates gentamicin-induced inflammation and apoptosis in human renal proximal tubular epithelial cells

Energy Technology Data Exchange (ETDEWEB)

Lee, Ko Eun [Department of Internal Medicine, Chonnam National University Medical School, Gwangju 501-757 (Korea, Republic of); Kim, Eun Young [Department of Physiology, Chonnam National University Medical School, Gwangju 501-757 (Korea, Republic of); Kim, Chang Seong; Choi, Joon Seok; Bae, Eun Hui; Ma, Seong Kwon [Department of Internal Medicine, Chonnam National University Medical School, Gwangju 501-757 (Korea, Republic of); Kim, Kyung Keun [Department of Pharmacology, Chonnam National University Medical School, Gwangju 501-757 (Korea, Republic of); Lee, Jong Un [Department of Physiology, Chonnam National University Medical School, Gwangju 501-757 (Korea, Republic of); Kim, Soo Wan, E-mail: skimw@chonnam.ac.kr [Department of Internal Medicine, Chonnam National University Medical School, Gwangju 501-757 (Korea, Republic of)

2013-05-10

Highlights: •MSP/RON system is activated in rat kidney damaged by gentamicin. •MSP inhibits GM-induced cellular apoptosis and inflammation in HK-2 cells. •MSP attenuates GM-induced activation of MAPKs and NF-κB pathways in HK-2 cells. -- Abstract: The present study aimed to investigate whether macrophage-stimulating protein (MSP) treatment attenuates renal apoptosis and inflammation in gentamicin (GM)-induced tubule injury and its underlying molecular mechanisms. To examine changes in MSP and its receptor, recepteur d’origine nantais (RON) in GM-induced nephropathy, rats were injected with GM for 7 days. Human renal proximal tubular epithelial (HK-2) cells were incubated with GM for 24 h in the presence of different concentrations of MSP and cell viability was measured by MTT assay. Apoptosis was determined by flow cytometry of cells stained with fluorescein isothiocyanate-conjugated annexin V protein and propidium iodide. Expression of Bcl-2, Bax, caspase-3, cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), nuclear factor-kappa B (NF-κB), IκB-α, and mitogen-activated protein kinases (MAPKs) was analyzed by semiquantitative immunoblotting. MSP and RON expression was significantly greater in GM-treated rats, than in untreated controls. GM-treatment reduced HK-2 cell viability, an effect that was counteracted by MSP. Flow cytometry and DAPI staining revealed GM-induced apoptosis was prevented by MSP. GM reduced expression of anti-apoptotic protein Bcl-2 and induced expression of Bax and cleaved caspase 3; these effects and GM-induced expression of COX-2 and iNOS were also attenuated by MSP. GM caused MSP-reversible induction of phospho-ERK, phospho-JNK, and phospho-p38. GM induced NF-κB activation and degradation of IκB-α; the increase in nuclear NF-κB was blocked by inhibitors of ERK, JNK, p-38, or MSP pretreatment. These findings suggest that MSP attenuates GM-induced inflammation and apoptosis by inhibition of the MAPKs

Oxidative stress, aging, and diseases

Directory of Open Access Journals (Sweden)

Liguori I

2018-04-01

Full Text Available Ilaria Liguori,1 Gennaro Russo,1 Francesco Curcio,1 Giulia Bulli,1 Luisa Aran,1 David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6 Domenico Bonaduce,1 Pasquale Abete1 1Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy; 2Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 3San Raffaele Roma Open University, Rome, Italy; 4Division of Internal Medicine, AOU San Giovanni di Dio e Ruggi di Aragona, Salerno, Italy; 5Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy; 6Azienda Ospedaliera dei Colli, Monaldi Hospital, Heart Transplantation Unit, Naples, Italy Abstract: Reactive oxygen and nitrogen species (RONS are produced by several endogenous and exogenous processes, and their negative effects are neutralized by antioxidant defenses. Oxidative stress occurs from the imbalance between RONS production and these antioxidant defenses. Aging is a process characterized by the progressive loss of tissue and organ function. The oxidative stress theory of aging is based on the hypothesis that age-associated functional losses are due to the accumulation of RONS-induced damages. At the same time, oxidative stress is involved in several age-related conditions (ie, cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer, including sarcopenia and frailty. Different types of oxidative stress biomarkers have been identified and may provide important information about the efficacy of the treatment, guiding the selection of the most effective drugs/dose regimens for patients and, if particularly relevant from a pathophysiological point of view, acting on a specific therapeutic target. Given the important role of oxidative stress in the pathogenesis of many clinical conditions and aging, antioxidant therapy could positively affect the natural history of

THE ECONOMIC IMPACT OF THE DIGESTIVE DISEASES ACROSS THE EU MEMBER STATES. THE COSTS ANALYSIS IN CHOLECYSTECTOMY

Directory of Open Access Journals (Sweden)

Uivaroşan Diana

2015-07-01

Full Text Available United European Gastroenterology provide wide studies and researches on the economic impact of the digestive diseases across the countries that are members of the European Union, very useful in planning health services, in making the case for investment in research where there are clear gaps in knowledge, and in reflecting the economic differences across the EU member states in the funding available to support health services. These studies reflect that there are important disparities in the accessibility to high-quality healthcare even among the industrialized countries. Out of all the digestive diseases, the gallstone disease is one of the most common and expensive of the health problems, in industrialized countries, like those of the European Union are. In general, symptomatic or complicated gallstone disease is treated by cholecystectomy, with surgical removal of the gallbladder. The advent of laparoscopic cholecystectomy has revolutionized the management of the gallstone disease, causing an increase in the rate of cholecystectomies. This study represents an analysis of the hospitalization costs involved by two surgical treatment options: laparoscopic cholecystectomy and open cholecystectomy. The investigation of the costs was done according to the type of intervention chosen and comprised the direct costs of hospitalization, including diagnostic tests and general expenses of medical assistance, pharmaceutical and medical supplies. The results are based on the analysis of the costs of cholecystectomies in the surgical department of the Emergency County Hospital Oradea for the year 2014 (781 cases. The average cost per hospitalized patient was 1.970 RON, lower in patients with laparoscopic cholecystectomy (1.579 RON. The average cost per patient with open cholecystectomy was 55% higher than for laparoscopic surgery (2.442 RON. Even if the laparoscopic operation cost is higher because of the equipment it uses, the reduction of the number of

Effect of air-excess on blends of RON70 partially premixed combustion

NARCIS (Netherlands)

Wang, S.; Bakker, P.C.; Somers, L.M.T.; de Goey, L.P.H.

Partially Premixed Combustion (PPC) is a combustion concept that aims to provide combustion with low smoke and NOx emissions and a high thermal efficiency. Extending the ignition delay to enhance premixing, avoiding spray-driven combustion, and controlling temperature at an optimum level through use

Ron Hays: A Story of Art as Self Treatment for Alzheimer's Disease

Science.gov (United States)

Jones, Robin M. N.; Hays, Nancy Scheller

2016-01-01

Ronald E. Hays is the former Director of the Hahnemann Creative Arts in Therapy Department at Drexel University in Philadelphia, Pennsylvania, and the cofounder of the graduate art therapy program at Eastern Virginia Medical School in Norfolk, Virginia. At the age of 62 he was diagnosed with early onset Alzheimer's disease, a form of dementia. In…

Assessing two Theoretical Frameworks of Civic Engagement

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Benilde García-Cabrero

2016-03-01

Full Text Available The purpose of this study was to empirically test two major theoretical models: a modified version of the social capital model (Pattie, Seyd and Whiteley, 2003, and the Informed Social Engagement Model (Barr and Selman, 2014; Selman and Kwok, 2010, to explain civic participation and civic knowledge of adolescents from Chile, Colombia and Mexico, using data from the International Civic and Citizenship Education Study 2009 (Schulz, et al., 2010. The models were used to identify factors associated with different levels of knowledge and civic participation: expected participation in legal and illegal protests, and electoral participation. Data were analyzed using regression analysis. Results show that the Informed Social Engagement approach (ISEM, explains better the observed differences in civic knowledge and civic participation, than the Social Capital Model (SCM. That is, the expected values associated with the variables included in the ISEM are closer to the observed values, than those predicted by the SCM. This is true for the three outcomes (expected participation in legal protests, illegal protests, and electoral participation and in the three countries analyzed (Chile, Colombia and Mexico.

An earth remote sensing satellite- 1 Synthetic Aperture Radar Mosaic of the Tanana River Basin in Alaska

Science.gov (United States)

Wivell, Charles E.; Olmsted, Coert; Steinwand, Daniel R.; Taylor, Christopher

1993-01-01

Because the pixel location in a line of Synthetic Aperture Radar (SAR) image data is directly related to the distance the pixel is from the radar, terrain elevations cause large displacement errors in the geo-referenced location of the pixel. This is especially true for radar systems with small angles between the nadir and look vectors. Thus, to geo-register a SAR image accurately, the terrain of the area must be taken into account. (Curlander et al., 1987; Kwok et al., 1987, Schreier et al., 1990; Wivell et al., 1992). As part of the 1992 National Aeronautics and Space Administration's Earth Observing System Version 0 activities, a prototype SAR geocod-. ing and terrain correction system was developed at the US. Geological Survey's (USGS) E~os Data Center (EDC) in Sioux Falls, South Dakota. Using this system with 3-arc-second digital elevation models (DEMs) mosaicked at the ED^ Alaska Field Office, 21 ERS-I s.4~ scenes acquired at the Alaska SAR Facility were automatically geocoded, terrain corrected, and mosaicked. The geo-registered scenes were mosaicked using a simple concatenation.

Our place in the universe understanding fundamental astronomy from ancient discoveries

CERN Document Server

Kwok, Sun

2017-01-01

If you have ever wanted to understand the basic principles of astronomy and celestial movements, you should read this book. Using pictures of the sky observed from different places on Earth, as well as drawings of ancient astronomical methods and tools, Prof. Sun Kwok tells this story in an entertaining and fascinating way. Since the beginning of human civilization, people have wondered about the structure of the cosmos and our place in the Universe. More than 2,000 years ago, our ancestors knew that the seasons were unequal, the Earth was an unattached object floating in space, and stars existed that they could not see. From celestial observations, they concluded that the Earth was round. Using simple tools and mathematics, ancient astronomers accurately determined the sizes of the Earth and Moon, the distance to the Moon, and the lengths of the months and year. With a clever device called the armillary sphere, Greek astronomers could predict the times of sunrise and sunset on any day of the year, at any pla...

Chemical Dynamics at Surfaces of Metal Nanomaterials

Science.gov (United States)

2014-07-23

distributed ermined bas 2 2 2 cos 1 2cos     iagonal pea ively. From angle betw le-mode 2D 2D-IR spec ss peak pair e excitation nd (E) A s...ron/vibratio larger than maller than tatively des f the vibrat hmarked w n in fig.46,7 olutions.15,1 egregate bec protein bui c “FRET” w r method ca

Resilience of Critical Infrastructure to Extreme Fires - Gaps and Challenges

Science.gov (United States)

2014-04-01

Defence Research and Development Canada’s Centre for Security Sciences who’s funding makes the study possible and the centre’s project manager for... managed this project . Ron Cowalchuk, Chief, Security Technology, Research and Development, Surface and Intermodal Security of Transport Canada, was...du Centre intégré de gestion de la circulation, Ministry of Transportation – Quebec Gary English, Assistant Fire Marshal – Special Projects , City of

1829-IJBCS-Article-Barry Mamoudou

African Journals Online (AJOL)

hp

Le Spirulina platensis est une algue utilisée pour ses effets nutritionnel et thérapeutique. De nombreuses études ont montré son intérêt ..... Mesure des cytokines (interleukine-4 (IL-4), l'interféron-γ (IFN-γ) et l'interleukine-2). - Réduction ... avec les métaux et les médicaments pouvant générer des radicaux libres toxiques ...

Skeletal Complications in Neurofibromatosis Type 1: the Role of Neurofibromin Haploinsufficiency in Defective Skeletal Remodeling and Bone Healing in NF1

Science.gov (United States)

2009-01-01

pathogenesis of pseudoarthrosis of the tibia (1). Health reports from the Vanderbilt mouse colony indicated exposure to mouse parvo virus (MPV) and...facility following the quarantine period and two, clean, consecutive monthly health reports, consistent with BIDMC Animal Research Facility animal...M.D., Sowa, H., Starbuck , M., Liu, X., Ron, D., Parada, L.F., and Karsenty, G. 2006. ATF4 mediation of NF1 functions in osteoblast reveals a

Structure and Bonding in Noncrystalline Solids Abstracts

Science.gov (United States)

1983-06-02

displacement cascades are unlikely. Related damage studies as diffuse X- ray scattering, magnetic susceptibility and positron - annihilation lifetime...the positron annihilation lifetime data; diffuse X-ray scattering studies give evidence for "amorphized" clusters in neutron but not in elec-ron...feldspar glasses and glasses in the system CaO- MgO -SiO 2 . These results indicate that the nearest-neighbor and next- nearest-neighbor environments are very

A Human-Automation Interface Model to Guide Automation Design of System Functions: A Way to Achieve Manning Goals in New Systems

Science.gov (United States)

2005-12-01

Manual (Army) FoS Family of Systems FRMV FCS Recovery and Maintenance Vehicle GDLS General Dynamics Land Systems HFE Human Factors Engineering...Thanks goes to our CRADA partners at BAE Systems (formerly UDLP) in Santa Clara, CA. Jeff Powers, Doug Neil, Gene Brennan, and Ron Natividad were eager...above in the HFE implications, MWL can be modeled during system design to assess if it is reasonable throughout system functional flow. Besides

Treatment-Induced Autophagy Associated with Tumor Dormancy and Relapse

Science.gov (United States)

2017-07-01

mechanisms make cellular transformation an inevitable event. Harmless somatic mutations have been reported in healthy hematopoietic stem cells of womenwith a...adult stem cells are also in a state of quiescent dormancy until they receive specific signals, such as tissue injury, to exit from dormancy and...lesions. RONS also induce DNA double- strand breaks, which can also be potently mutagenic if not accurately repaired. How- ever, detection of malignant

Antioxidant supplementation does not alter endurance training adaptation

DEFF Research Database (Denmark)

Yfanti, Christina; Åkerström, Thorbjörn; Nielsen, Søren

2010-01-01

) production, which may cause cell damage. However, RONS production may also activate redox sensitive signaling pathways and transcription factors, which subsequently may promote training adaptation. PURPOSE: Our aim was to investigate the effects of combined vitamin C and E supplementation to healthy...... measured. CONCLUSION: Our results suggest that administration of vitamins C and E to individuals with no prior vitamin deficiencies has no effect on physical adaptations to strenuous endurance training....

Effects of Temperature and Environment on Creep Behavior of an Oxide-Oxide Ceramic Matrix Composite

Science.gov (United States)

2007-03-01

Zelina, Dr. Ruth Sikorski, and Dr. Ron Kerans, whose sponsorship made my research possible; Dr. Robert Canfield and Dr. Som Soni, for their membership...on my thesis committee and discerning comments; Lt Joseph Broeckert, Lt Christina Falcone, Capt Christine Ladrido, and LT Robert Salvia, whose...Society for Testing and Materials (1997). 54. Raymer , D.P. Aircraft Design: A Conceptual Approach, 3rd Edition. Reston, VA: American Institute of

Long-term Problems of Land Contaminated by Nonradioactive Hazardous Chemicals: Sources, Impacts, and Countermeasures

Science.gov (United States)

1987-01-01

Chromium deficiency in animals produces symptoms similar to those for diabetes . Deficiencies of chromiu,n have also been associated with heart disease...widespread mercury poisonings from environmental sources. In the early 1960s several instances of methyl mercury poisoning occurred in Iraq, Guatemala , and...carbon dioxide, wpter vapor, and ash; minor effluents include sulfur-, nitrogen-, andPi ’:uy,-n -ccntallnhi( products that may be of signifi..ant en ~ron6

Distribution functions for a family of general-relativistic hypervirial models in the collisionless regime

Science.gov (United States)

Gauy, Henrique Matheus; Ramos-Caro, Javier

2018-03-01

By considering the Einstein-Vlasov system for static spherically symmetric distributions of matter, we show that configurations with constant anisotropy parameter β , leading to asymptotically flat spacetimes, have necessarily a distribution function (DF) of the form F =l-2 βξ (ɛ ) , where ɛ =E /m and l =L /m are the relativistic energy and angular momentum per unit rest mass, respectively. We exploit this result to obtain DFs for the general relativistic extension of the hypervirial family introduced by Nguyen and Lingam [Mon. Not. R. Astron. Soc. 436, 2014 (2013), 10.1093/mnras/stt1719], which Newtonian potential is given by ϕ (r )=-ϕo/[1 +(r /a )n]1 /n (a and ϕo are positive free parameters, n =1 ,2 ,… ). Such DFs can be written in the form Fn=ln -2ξn(ɛ ) . For odd n , we find that ξn is a polynomial of order 2 n +1 in ɛ , as in the case of the Hernquist model (n =1 ), for which F1∝l-1(2 ɛ -1 ) (ɛ-1 ) 2 . For even n , we can write ξn in terms of incomplete beta functions (Plummer model, n =2 , is an example). Since we demand that F ≥0 throughout the phase space, the particular form of each ξn leads to restrictions for the values of ϕo. For example, for the Hernquist model we find that 0 ≤ϕo≤2 /3 , i.e., an upper bounding value less than the one obtained for Nguyen and Lingam (0 ≤ϕo≤1 ), based on energy conditions.

Kcne2 deletion impairs insulin secretion and causes type 2 diabetes mellitus.

Science.gov (United States)

Lee, Soo Min; Baik, Jasmine; Nguyen, Dara; Nguyen, Victoria; Liu, Shiwei; Hu, Zhaoyang; Abbott, Geoffrey W

2017-06-01

Type 2 diabetes mellitus (T2DM) represents a rapidly increasing threat to global public health. T2DM arises largely from obesity, poor diet, and lack of exercise, but it also involves genetic predisposition. Here we report that the KCNE2 potassium channel transmembrane regulatory subunit is expressed in human and mouse pancreatic β cells. Kcne2 deletion in mice impaired glucose tolerance as early as 5 wk of age in pups fed a Western diet, ultimately causing diabetes. In adult mice fed normal chow, skeletal muscle expression of insulin receptor β and insulin receptor substrate 1 were down-regulated 2-fold by Kcne2 deletion, characteristic of T2DM. Kcne2 deletion also caused extensive pancreatic transcriptome changes consistent with facets of T2DM, including endoplasmic reticulum stress, inflammation, and hyperproliferation. Kcne2 deletion impaired β-cell insulin secretion in vitro up to 8-fold and diminished β-cell peak outward K + current at positive membrane potentials, but also left-shifted its voltage dependence and slowed inactivation. Interestingly, we also observed an aging-dependent reduction in β-cell outward currents in both Kcne2 +/+ and Kcne2 - / - mice. Our results demonstrate that KCNE2 is required for normal β-cell electrical activity and insulin secretion, and that Kcne2 deletion causes T2DM. KCNE2 may regulate multiple K + channels in β cells, including the T2DM-linked KCNQ1 potassium channel α subunit.-Lee, S. M., Baik, J., Nguyen, D., Nguyen, V., Liu, S., Hu, Z., Abbott, G. W. Kcne2 deletion impairs insulin secretion and causes type 2 diabetes mellitus. © FASEB.

CFD study of fluid flow changes with erosion

Science.gov (United States)

López, Alejandro; Stickland, Matthew T.; Dempster, William M.

2018-06-01

For the first time, a three dimensional mesh deformation algorithm is used to assess fluid flow changes with erosion. The validation case chosen is the Jet Impingement Test, which was thoroughly analysed in previous works by Hattori et al. (Kenichi Sugiyama and Harada, 2008), Gnanavelu et al. in (Gnanavelu et al., 2009, 2011), Lopez et al. in (Lopez et al., 2015) and Mackenzie et al. in (Mackenzie et al., 2015). Nguyen et al. (2014) showed the formation of a new stagnation area when the wear scar is deep enough by performing a three-dimensional scan of the wear scar after 30 min of jet impingement test. However, in the work developed here, this stagnation area was obtained solely by computational means. The procedure consisted of applying an erosion model in order to obtain a deformed geometry, which, due to the changes in the flow pattern lead to the formation of a new stagnation area. The results as well as the wear scar were compared to the results by Nguyen et al. (2014) showing the same trend. OpenFOAM® was the software chosen for the implementation of the deforming mesh algorithm as well as remeshing of the computational domain after deformation. Different techniques for mesh deformation and approaches to erosion modelling are discussed and a new methodology for erosion calculation including mesh deformation is developed. This new approach is independent of the erosion modelling approach, being applicable to both Eulerian and Lagrangian based equations for erosion calculation. Its different applications such as performance decay in machinery subjected to erosion as well as modelling of natural erosion processes are discussed here.

Highlighted Activities of ICCASA 2015

Directory of Open Access Journals (Sweden)

Nguyen Thanh Tung

2015-08-01

Full Text Available The Fourth International Conference on Context-Aware Systems and Applications (ICCASA 2015 [1] is jointly organized by EAI, Nguyen Tat Thanh University (NTTU, and Ba Ria-Vung Tau University (BRVTU and endorsed by the European Alliance for Innovation (EAI, a leading community-based organization devoted to the advancement of innovation in the field of ICT. The event consists of a main track on context-aware systems and applications, and two special tracks on contextual recommendation systems and on computational aspects of context in natural language processing, respectively. Especially, there are three keynote speeches, which will be presented at ICCASA 2015 by prominent invited speakers.

Measurement of mass flux in two-phase flow using combinations of Pitot tubes and gamma densitometers

International Nuclear Information System (INIS)

Hau, K.F.F.L.; Banerjee, S.

1981-01-01

New experimental data indicate that mass flux in cocurrent gas-liquid flows may be determined by the use of Pitot tubes in conjunction with a local mixture density measurement technique. The data were taken over a wide range of flow regimes in a horizontal pipe and included separated patterns such as stratified and annular flows. Local mixture densities were obtained by a computer-assisted algebraic reconstruction technique that used chordal average densities measured by traversing gamma beam attenuation. The results extend the applicability of this mass flux measurement technique well beyond the relatively homogeneous, high-pressure, steam-water flow situations originally studied by S. Banerjee and D.M. Nguyen. 13 refs

Effect of magnetic resonance imaging characteristics on uterine fibroid treatment

Directory of Open Access Journals (Sweden)

Duc NM

2018-04-01

Full Text Available Nguyen Minh Duc, Huynh Quang HuyDepartment of Radiology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, VietnamAbstract: Uterine fibroids are the most common gynecological benign tumors adversely affecting the quality of life of women of a reproductive age. Magnetic resonance imaging (MRI is efficient at localizing the site of lesions and characterizing uterine fibroids before treatment. Understanding the different characteristics of uterine fibroids on MRI is essential, because it not only enables prompt diagnosis, but also guides the development of suitable therapeutic methods. This pictorial review demonstrates the effect of MRI features on uterine fibroid treatment. Keywords: uterine fibroids, characteristics, magnetic resonance imaging, treatments

A MATLAB toolbox for the analysis of articulatory data in the production of speech.

Science.gov (United States)

Nguyen, N

2000-08-01

The goal of this paper is to present EMATOOLS, a set of scripts for displaying and annotating acoustic and articulatory data simultaneously in studies on speech production. These scripts were developed with the use of MATLAB, a multiplatform computing environment for numeric computation and visualization. The system is equipped with a mouse-driven graphical interface made up of a number of displays. This interface can be easily customized to speed up routine tasks. The scripts can also be used in a noninteractive way, as stand-alone MATLAB commands. Output data can be imported into any standard spreadsheet. EMATOOLS is freely available from www.lpl.univ-aix.fr/nguyen/ematools.html.

A revision of Ichneumonopsis Hardy, 1973 (Diptera: Tephritidae: Dacinae: Gastrozonini, Oriental bamboo-shoot fruit flies

Directory of Open Access Journals (Sweden)

Amnon Freidberg

2017-05-01

Full Text Available Ichneumonopsis Hardy,1973, a genus of oriental fruit flies, is revised and two new species, I. hancocki sp. nov. (from Peninsular Malaysia and I. taiwanensis sp. nov. (from Taiwan, are described. A key to the three species of Ichneumonopsis is presented. In northern Thailand larvae of I. burmensis Hardy, 1973 develop in bamboo shoots of Pseudoxytenanthera albociliata (Munro Nguyen and Dendrocalamus strictus (Roxburgh Nees (Poaceae, not Melocalamus compactiflorus as previously reported. The recently discovered association of I. burmensis with bamboo substantiates our previous assumption assigning Ichneumonopsis to the primarily bamboo-inhabiting tribe Gastrozonini. Hence, we synonymize Ichneumonopsidini under Gastrozonini (syn. nov..

Molecular insights into the interaction between Plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide.

Directory of Open Access Journals (Sweden)

Geqing Wang

Full Text Available Apical membrane antigen 1 (AMA1 of the human malaria parasite Plasmodium falciparum has been implicated in invasion of the host erythrocyte. It interacts with malarial rhoptry neck (RON proteins in the moving junction that forms between the host cell and the invading parasite. Agents that block this interaction inhibit invasion and may serve as promising leads for anti-malarial drug development. The invasion-inhibitory peptide R1 binds to a hydrophobic cleft on AMA1, which is an attractive target site for small molecules that block parasite invasion. In this work, truncation and mutational analyses show that Phe5-Phe9, Phe12 and Arg15 in R1 are the most important residues for high affinity binding to AMA1. These residues interact with two well-defined binding hot spots on AMA1. Computational solvent mapping reveals that one of these hot spots is suitable for small molecule targeting. We also confirm that R1 in solution binds to AMA1 with 1:1 stoichiometry and adopts a secondary structure consistent with the major form of R1 observed in the crystal structure of the complex. Our results provide a basis for designing high affinity inhibitors of the AMA1-RON2 interaction.

Generation and Role of Reactive Oxygen and Nitrogen Species Induced by Plasma, Lasers, Chemical Agents, and Other Systems in Dentistry

Science.gov (United States)

Jha, Nayansi; Ryu, Jae Jun

2017-01-01

The generation of reactive oxygen and nitrogen species (RONS) has been found to occur during inflammatory procedures, during cell ischemia, and in various crucial developmental processes such as cell differentiation and along cell signaling pathways. The most common sources of intracellular RONS are the mitochondrial electron transport system, NADH oxidase, and cytochrome P450. In this review, we analyzed the extracellular and intracellular sources of reactive species, their cell signaling pathways, the mechanisms of action, and their positive and negative effects in the dental field. In dentistry, ROS can be found—in lasers, photosensitizers, bleaching agents, cold plasma, and even resin cements, all of which contribute to the generation and prevalence of ROS. Nonthermal plasma has been used as a source of ROS for biomedical applications and has the potential for use with dental stem cells as well. There are different types of dental stem cells, but their therapeutic use remains largely untapped, with the focus currently on only periodontal ligament stem cells. More research is necessary in this area, including studies about ROS mechanisms with dental cells, along with the utilization of reactive species in redox medicine. Such studies will help to provide successful treatment modalities for various diseases. PMID:29204250

Ga2O3 Schottky rectifiers with 1 ampere forward current, 650 V reverse breakdown and 26.5 MW.cm-2 figure-of-merit

Science.gov (United States)

Yang, Jiancheng; Ren, F.; Tadjer, Marko; Pearton, S. J.; Kuramata, A.

2018-05-01

A key goal for Ga2O3 rectifiers is to achieve high forward currents and high reverse breakdown voltages. Field-plated β-Ga2O3 Schottky rectifiers with area 0.01 cm2, fabricated on 10 μm thick, lightly-doped drift regions (1.33 x 1016 cm-3) on heavily-doped (3.6 x 1018 cm-3) substrates, exhibited forward current density of 100A.cm-2 at 2.1 V, with absolute current of 1 A at this voltage and a reverse breakdown voltage (VB) of 650V. The on-resistance (RON) was 1.58 x 10-2 Ω.cm2, producing a figure of merit (VB2/RON) of 26.5 MW.cm-2. The Schottky barrier height of the Ni was 1.04 eV, with an ideality factor of 1.02. The on/off ratio was in the range 3.3 x 106 - 5.7 x 109 for reverse biases between 5 and 100V. The reverse recovery time was ˜30 ns for switching from +2V to -5V. The results show the capability of β-Ga2O3 rectifiers to achieve exceptional performance in both forward and reverse bias conditions.

Cold plasma interactions with plants: Morphing and movements of Venus flytrap and Mimosa pudica induced by argon plasma jet.

Science.gov (United States)

Volkov, Alexander G; Xu, Kunning G; Kolobov, Vladimir I

2017-12-01

Low temperature (cold) plasma finds an increasing number of applications in biology, medicine and agriculture. In this paper, we report a new effect of plasma induced morphing and movements of Venus flytrap and Mimosa pudica. We have experimentally observed plasma activation of sensitive plant movements and morphing structures in these plants similar to stimulation of their mechanosensors in vivo. Application of an atmospheric pressure argon plasma jet to the inside or outside of a lobe, midrib, or cilia in Dionaea muscipula Ellis induces trap closing. Treatment of Mimosa pudica by plasma induces movements of pinnules and petioles similar to the effects of mechanical stimulation. We have conducted control experiments and simulations to illustrate that gas flow and UV radiation associated with plasma are not the primary reasons for the observed effects. Reactive oxygen and nitrogen species (RONS) produced by cold plasma in atmospheric air appear to be the primary reason of plasma-induced activation of phytoactuators in plants. Some of these RONS are known to be signaling molecules, which control plants' developmental processes. Understanding these mechanisms could promote plasma-based technology for plant developmental control and future use for plant protection from pathogens. Our work offers new insight into mechanisms which trigger plant morphing and movement. Copyright © 2017 Elsevier B.V. All rights reserved.

Astaxanthin in Exercise Metabolism, Performance and Recovery: A Review

Directory of Open Access Journals (Sweden)

Daniel R. Brown

2018-01-01

Full Text Available During periods of heavy exercise training and competition, lipid, protein, and nucleic molecules can become damaged due to an overproduction of reactive oxygen and nitrogen species (RONS within the exercising organism. As antioxidants can prevent and delay cellular oxidative damage through removing, deactivating, and preventing the formation of RONS, supplementation with exogenous antioxidant compounds has become a commercialized nutritional strategy commonly adopted by recreationally active individuals and athletes. The following review is written as a critical appraisal of the current literature surrounding astaxanthin and its potential application as a dietary supplement in exercising humans. Astaxanthin is a lipid-soluble antioxidant carotenoid available to supplement through the intake of Haematococcus pluvialis-derived antioxidant products. Based upon in vitro and in vivo research conducted in mice exercise models, evidence would suggest that astaxanthin supplementation could potentially improve indices of exercise metabolism, performance, and recovery because of its potent antioxidant capacity. In exercising humans, however, these observations have yet to be consistently realized, with equivocal data reported. Implicated, in part, by the scarcity of well-controlled, scientifically rigorous research, future investigation is necessary to enable a more robust conclusion in regard to the efficacy of astaxanthin supplementation and its potential role in substrate utilization, endurance performance, and acute recovery in exercising humans.

ANALYSIS OF EPIDEMIOLOGICAL AND HEALTH-ECONOMIC INDICATORS IN CASE OF CHILDREN OCULAR TRAUMA

Directory of Open Access Journals (Sweden)

Laurentiu STUPARIU

2017-12-01

Full Text Available Analysis of epidemiological and health-economic indicators on ocular trauma involving children is important for developing targeted managerial, medical and educational strategies of health care providers and patients in order to reduce incidence and severity of pediatric ocular trauma. We analysed data collected from 29 children with ocular trauma from Emergency Hospital of Sibiu, between 2008-2016. For this children with closed globe injury it took an average of 7 days of hospitalization (IQR: (5; 9.5, with a cost per day of hospitalization on average of 127 RON (IQR: (103; 136, respectively a total hospitalization cost on average 856 RON (IQR: (529; 998, with no significant gender or area differences. It took a slightly larger number of hospitalization days in the following situations: (1 in the case of mixed trauma compared to lamellar lacerations or contusions; (2 if the affected area was zone III compared to the other two areas (zone I and zone II; (3 where the visual acuity at admission was less than 1/6(0.16 compared to cases with visual acuity greater than 1/6(0.16; (4 in patients with hypertension at admission compared to those with normal tension or hypotension.

The Minnesota Innovation Research Program.

Science.gov (United States)

1984-04-01

Jeanne Buckeye, Ron Dykstra, Roger Hudson, and Andrew Van de Ven 42 Financial Industry Innovation Study -- Ian Maitland , Robert Goodman, and Edward...PROJECT by Ian Maitland , Robert S. Goodman, and Ed Freeman We propose to examine the strategic innovations undertaken by a stratified sample of financial...with it. A sample of 6 innovati 1ve and 6 "noninrovative" school districts will be lonoitudinallv studied utsini interviews. direct observat ian , and

Special Inspector General for Afghanistan Reconstruction

Science.gov (United States)

2014-01-30

International Building Code specifications. SIGAR also found that USAID lacks building roof and septic tank structural calculations; an analysis of which...is critical to ensure that the roof and septic tank as constructed will support the loads imposed on them. The absence of such calculations raises...point to the septic tank has a solid cast iron cover or a permanent ladder, both of which are required by the contract. (SIGAR photo by Ron Riach

A Decision Model for Selection of Microcomputers and Operating Systems.

Science.gov (United States)

1984-06-01

is resilting in application software (for microccmputers) being developed almost exclu- sively tor the IBM PC and compatiole systems. NAVDAC ielt that...location can be indepen- dently accessed. RAN memory is also often called read/ write memory, hecause new information can be written into and read from...when power is lost; this is also read/ write memory. Bubble memory, however, has significantly slower access times than RAM or RON and also is not preva

"Da Vinci kood" endiselt lahti muukimata / Riho Laurisaar, Eda Post

Index Scriptorium Estoniae

Laurisaar, Riho

2006-01-01

Dan Browni samanimelise menuromaani järgi valminud põnevusfilm "Da Vinci kood" (režissöör Ron Howard, produtsent Brian Greiser) on tekitanud aktiivset vastukaja kristlaste ringkondades. Lisatud : "Kirjanik. Dan Brown : usklikust koolipoisist sai väidetav usurüvetaja", "Raamat. Raamatut müüakse endiselt miljonites", "Vastasseis. Usklikud ühinevad "Da Vinci koodi vastu", "Kirjastus. Kohus vabastas Dan Browni plagiaadisüüdistusest", "Reisid. Turismifirmad võtavad graalihulluselt matti"

The Use of EPI-Splines to Model Empirical Semivariograms for Optimal Spatial Estimation

Science.gov (United States)

2016-09-01

7, pp 765–773, 1996. [20] A. Ron, (2010, Oct. 26). CS412: Introduction to numerical analysis, Lecture 14: Linear algebra , [Online]. Available: http...accomplished through a system of linear equations. Normally this is accomplished as part of a batch operation where the data is first collected and the... elementary tutorial. What follows is a discussion of the formulation of the minimization problem and how the required vectors and matrices are defined

Review essays on: Key Thinkers on Space and Place

OpenAIRE

Boyle, Mark

2005-01-01

Twenty years ago it was common to bemoan the lack of textbooks on the history and philosophy of geography. Although Arild Holt-Jensen's (1999) Geography:History and Concepts (first published in English in 1981) was the first book to systematically chart different approaches to geographic thought, it was Ron Johnston's Geography and Geographers:Anglo-American Geography Since 1945 (first published in 1979) that occupied premium position in the marketplace. Applying Kuhn's paradig...

Steward of Headwaters: U.S. Army Corps of Engineers, St. Paul District, 1975-2000

Science.gov (United States)

2012-01-01

to their shells, thereby preventing them from migrating or burrowing .73 The St. Paul District initiated a monitoring process of the zebra mussel at...P ro je ct s 4 104 Strong Move, 13 February 1997, File LaFarge Ho Chunk, Box 6410, SPDAR; Ron Wilber to Larry Garvin, HoChunk Researcher, 10...July 1987, File Congressional Correspondence, Box 6412, SPDAR. 39 Larry and Diane Uhlir to Mr. Gregg Struss, Resource Manager, Gull Lake Recreation

The United States Air Force in Korea 1950-1953

Science.gov (United States)

1983-01-01

volume through various stages of publication. Further appreciation is extended to Mr. Bruce Plumb, Typography and Design Division of the U.S...negative reactions . and. Brown thus destroyed the first Commu- following the collapse of the United nist jet aircraft to be shot down in Nations...Decisions "Enemy reactions developed in the Almond’s forces in those areas. [ron course of our assault operations of the such positions on the eastern

Summer Research Paper

Science.gov (United States)

Patel, Zarana

2011-01-01

Certain populations such as chemotherapy patients and atomic bomb survivors have been exposed to ionizing radiation and experience tissue damage and cancer initiation and progression. One cancer that can be initiated from radiation is esophageal squamous cell carcinoma (ESCC), an epithelial cancer that has a survival rate as low as 20%. Researchers have found that when protein tyrosine kinase receptors (RPTK) activate oncogenes, they can create epithelial tumors and cause deadly cancers like ESCC. The RPTK family has one group, MET, that has only two receptors, MET and RON, present in the human body. MET s ligand is the hepatocyte growth factor (HGF) and RON's ligand is the macrophage-stimulating protein (MSP-1). Both HGF and MSP-1 have been shown to activate their receptors and are implicated in certain processes. Since radiation damages cells throughout the biological system, researchers are investigating whether or not HGF and MSP-1 protects or kills certain normal and cancerous cells by being part of cell recovery processes. One research group recently reviewed that the HGF-MET pathway has an important role in the embryonic development in the liver, migration of myogenic precursor cells, regulation of epithelial morphogenesis and growth, and regeneration and protection in tissues. In addition, since the RON receptor is more commonly expressed in cells of epithelial origin, and when activated is part of epithelial cell matrix invasion, dissociation, and migration processes, scientists conclude that RON might be one of the factors causing epithelial cancer initiation in the biological system. In order to examine HGF and MSP-1 s effect on cancer initiation and progression we used two immortalized esophageal epithelial cell lines. One is a normal human cell line (EPC2-hTERT), while the other had a p53 mutation at the 175th amino acid position (EPC2-hTERT-p53(sup R175H)). For this investigation, we used 0(control), 2, and 4 Gray doses of gamma (Cs137) radiation and

Positive matrix factorization and trajectory modelling for source identification: A new look at Indian Ocean Experiment ship observations

Science.gov (United States)

Bhanuprasad, S. G.; Venkataraman, Chandra; Bhushan, Mani

The sources of aerosols on a regional scale over India have only recently received attention in studies using back trajectory analysis and chemical transport modelling. Receptor modelling approaches such as positive matrix factorization (PMF) and the potential source contribution function (PSCF) are effective tools in source identification of urban and regional-scale pollution. In this work, PMF and PSCF analysis is applied to identify categories and locations of sources that influenced surface concentrations of aerosols in the Indian Ocean Experiment (INDOEX) domain measured on-board the research vessel Ron Brown [Quinn, P.K., Coffman, D.J., Bates, T.S., Miller, T.L., Johnson, J.E., Welton, E.J., et al., 2002. Aerosol optical properties during INDOEX 1999: means, variability, and controlling factors. Journal of Geophysical Research 107, 8020, doi:10.1029/2000JD000037]. Emissions inventory information is used to identify sources co-located with probable source regions from PSCF. PMF analysis identified six factors influencing PM concentrations during the INDOEX cruise of the Ron Brown including a biomass combustion factor (35-40%), three industrial emissions factors (35-40%), primarily secondary sulphate-nitrate, balance trace elements and Zn, and two dust factors (20-30%) of Si- and Ca-dust. The identified factors effectively predict the measured submicron PM concentrations (slope of regression line=0.90±0.20; R2=0.76). Probable source regions shifted based on changes in surface and elevated flows during different times in the ship cruise. They were in India in the early part of the cruise, but in west Asia, south-east Asia and Africa, during later parts of the cruise. Co-located sources include coal-fired electric utilities, cement, metals and petroleum production in India and west Asia, biofuel combustion for energy and crop residue burning in India, woodland/forest burning in north sub-Saharan Africa and forest burning in south-east Asia. Significant findings

Tank 241-AY-101 Privatization Push Mode Core Sampling and Analysis Plan

International Nuclear Information System (INIS)

TEMPLETON, A.M.

2000-01-01

This sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for samples obtained from tank 241-AY-101. The purpose of this sampling event is to obtain information about the characteristics of the contents of 241-AY-101 required to satisfy Data Quality Objectives For RPP Privatization Phase I: Confirm Tank T Is An Appropriate Feed Source For High-Level Waste Feed Batch X(HLW DQO) (Nguyen 1999a), Data Quality Objectives For TWRS Privatization Phase I : Confirm Tank T Is An Appropriate Feed Source For Low-Activity Waste Feed Batch X (LAW DQO) (Nguyen 1999b), Low Activity Waste and High-Level Waste Feed Data Quality Objectives (L and H DQO) (Patello et al. 1999), and Characterization Data Needs for Development, Design, and Operation of Retrieval Equipment Developed through the Data Quality Objective Process (Equipment DQO) (Bloom 1996). Special instructions regarding support to the LAW and HLW DQOs are provided by Baldwin (1999). Push mode core samples will be obtained from risers 15G and 150 to provide sufficient material for the chemical analyses and tests required to satisfy these data quality objectives. The 222-S Laboratory will extrude core samples; composite the liquids and solids; perform chemical analyses on composite and segment samples; archive half-segment samples; and provide subsamples to the Process Chemistry Laboratory. The Process Chemistry Laboratory will prepare test plans and perform process tests to evaluate the behavior of the 241-AY-101 waste undergoing the retrieval and treatment scenarios defined in the applicable DQOs. Requirements for analyses of samples originating in the process tests will be documented in the corresponding test plans and are not within the scope of this SAP

Tank 241-AY-101 Privatization Push Mode Core Sampling and Analysis Plan

International Nuclear Information System (INIS)

TEMPLETON, A.M.

2000-01-01

This sampling and analysis plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for samples obtained from tank 241-AY-101. The purpose of this sampling event is to obtain information about the characteristics of the contents of 241-AY-101 required to satisfy ''Data Quality Objectives For RPP Privatization Phase I: Confirm Tank T Is An Appropriate Feed Source For High-Level Waste Feed Batch X(HLW DQO)' (Nguyen 1999a), ''Data Quality Objectives For TWRS Privatization Phase I: Confirm Tank T Is An Appropriate Feed Source For Low-Activity Waste Feed Butch X (LAW DQO) (Nguyen 1999b)'', ''Low Activity Waste and High-Level Waste Feed Data Quality Objectives (L and H DQO)'' (Patello et al. 1999), and ''Characterization Data Needs for Development, Design, and Operation of Retrieval Equipment Developed through the Data Quality Objective Process (Equipment DQO)'' (Bloom 1996). Special instructions regarding support to the LAW and HLW DQOs are provided by Baldwin (1999). Push mode core samples will be obtained from risers 15G and 150 to provide sufficient material for the chemical analyses and tests required to satisfy these data quality objectives. The 222-S Laboratory will extrude core samples; composite the liquids and solids; perform chemical analyses on composite and segment samples; archive half-segment samples; and provide sub-samples to the Process Chemistry Laboratory. The Process Chemistry Laboratory will prepare test plans and perform process tests to evaluate the behavior of the 241-AY-101 waste undergoing the retrieval and treatment scenarios defined in the applicable DQOs. Requirements for analyses of samples originating in the process tests will be documented in the corresponding test plans and are not within the scope of this SAP

High mortality associated with tapeworm parasitism in geladas (Theropithecus gelada) in the Simien Mountains National Park, Ethiopia.

Science.gov (United States)

Schneider-Crease, India; Griffin, Randi H; Gomery, Megan A; Bergman, Thore J; Beehner, Jacinta C

2017-09-01

Despite increasing appreciation for parasitism as an important component of primate ecology and evolution, surprisingly few studies have demonstrated the costs of helminth parasitism in primates. Detecting parasite-related costs in primates is particularly difficult because it requires detailed, long-term data on individual host reproductive success, survival, and parasitism. The identification of the larval tapeworm Taenia serialis in geladas under intensive long-term study in the Ethiopian Highlands (Nguyen et al. [2015] American Journal of Primatology, 77:579-594; Schneider-Crease et al. [2013] Veterinary Parasitology 198:240-243) provides an opportunity to examine how an endemic parasite impacts host reproductive success and survival. We used survival analyses to assess the mortality risk associated with protuberant larval cysts characteristic of T. serialis using a decade of data from a gelada population in the Simien Mountains National Park (SMNP), Ethiopia. We demonstrated strikingly high mortality associated with T. serialis cysts in adult females, particularly for younger adults. The estimated effect of cysts on male mortality was similar, although the effect was not statistically significant, likely owing to the smaller sample size. Additionally, the offspring of mothers with cysts experienced increased mortality, which was driven almost entirely by maternal death. Mothers with cysts had such high mortality that they rarely completed an interbirth interval. Comparison with a study of this parasite in another gelada population on the Guassa Plateau (Nguyen et al. [2015] American Journal of Primatology, 77:579-594) revealed lower cyst prevalence in the SMNP and similar cyst-associated mortality. However, many more females with cysts completed interbirth intervals at Guassa than in the SMNP, suggesting that T. serialis cysts may kill hosts more rapidly in the SMNP. Our results point toward the underlying causes of individual and population

Earth orientation and its excitations by atmosphere, oceans, and geomagnetic jerks

OpenAIRE

Vondrák J.; Ron C.

2015-01-01

In addition to torques exerted by the Moon, Sun, and planets, changes of the Earth orientation parameters (EOP) are known to be caused also by excitations by the atmosphere and oceans. Recently appeared studies, hinting that geomagnetic jerks (GMJ, rapid changes of geomagnetic field) might be associated with sudden changes of phase and amplitude of EOP (Holme and de Viron 2005, 2013, Gibert and Le Mouёl 2008, Malkin 2013). We (Ron et al. 2015) used addition...

Cereus peruvianus (Koubo) new cactus fruit for the world

OpenAIRE

Mizrahi, Yosef

2014-01-01

Several different species of the columnar cacti of the genera Stenocereus and Pachycereus, were introduced into different semi-arid ecozones in Israel and most of these efforts were of disappointing outcomes, the only exception being the Cereus peruvianus (L.) Miller,which bore plenty of fruits, some of them of good taste. The original seeds of this plant were obtained from the late Mr. Amram (Ron) Kodish, who collected seeds from various private gardens in Southern California which bore frui...

THE DETERMINATS OF THE UNEMPLOYMENT RATE EMPIRICAL EVIDENCE FROM ROMANIA

Directory of Open Access Journals (Sweden)

Pall Katalin

2010-12-01

Full Text Available Among other aspects, the 2007-2009 financial and economic crisis had an impact on the Romanian labor force, too. The aim of this article is to analyze the macroeconomic determinants of the unemployment rate in Romania, using an econometric model. We use the GDP, net and gross wage, monetary policy rate, inflation rate, budget deficit, average RON/EUR exchange rate, export and import values to estimate the model. The analyzed period is 2000-2009.

Improve your reading

CERN Document Server

Fry, Ron

2012-01-01

Help your students discover the practical solution to their reading frustrations, with Improve Your Reading. Written by bestselling author and education advocate Ron Fry, this book avoids gimmicks and tricks in favor of proven strategies that will help your students better retain and comprehend what they've read in any textbook, in any course, at any academic level. Endlessly adaptable to each student's individual learning needs, the text focuses on fundamental skills students can carry beyond the classroom.

Calculations of the self-amplified spontaneous emission performance of a free-electron laser

International Nuclear Information System (INIS)

Dejus, R. J.

1999-01-01

The linear integral equation based computer code (RON: Roger Oleg Nikolai), which was recently developed at Argonne National Laboratory, was used to calculate the self-amplified spontaneous emission (SASE) performance of the free-electron laser (FEL) being built at Argonne. Signal growth calculations under different conditions are used for estimating tolerances of actual design parameters. The radiation characteristics are discussed, and calculations using an ideal undulator magnetic field and a real measured magnetic field will be compared and discussed

Modeling of Residual Stress and Machining Distortion in Aerospace Components (PREPRINT)

Science.gov (United States)

2010-03-01

John Gayda, “The Effect of Heat Treatment on Residual Stress and Machining Distortions in Advanced Nickel Base Disk Alloys,” NASA/TM-2001-210717. 2...Wei-Tsu Wu, Guoji Li, Juipeng Tang, Shesh Srivatsa, Ravi Shankar, Ron Wallis, Padu Ramasundaram and John Gayda, “A process modeling system for heat...Materials Processing Technology 98 (2000) 189-195. 6. M.A. Rist, S. Tin, B.A. Roder, J.A. James, and M.R. Daymond , “Residual Stresses in a

Popular music as an anticipation, “framing” and construction of generational memory of the 1968 students’ protest in Yugoslavia

OpenAIRE

Vasiljević Maja

2013-01-01

By focusing on the role of music within a certain political event - in this case, the students’ protests in Yugoslavia in June 1968 - I connect the sociology of music with the sociology of social movements as defined by American writers Ron Eyerman and Andrew Jamison. Moreover, I suggest further research based on the sociology of generations. I insist on the cultural basis of social movements, as argued by these Yale-educated sociologists. Contrary to the t...

Global health intervention from North to South: (Academic) preparation of students

DEFF Research Database (Denmark)

Singla, Rashmi; Rasmussen, Louise Mubanda

2018-01-01

psychiatry/ psychology (Fernando), culture-centered health communication (Dutta) and medical anthropology (Farmer, Nguyen & Lock). The course is framed around a critical conceptualization of globalisation covering spatial and ideological dimensions (Fassin). Today’s practice of global health interventions......Global health intervention from North to South: (Academic) preparation of students By Rashmi Singla & Louise Mubanda Rasmussen, Roskilde University, Denmark This chapter discusses how to conduct before- intervention preparation of students based on a pioneer course collaboration between...... the subjects Health Promotion and International Development Studies at Roskilde University. The focus is on agents of intervention from the Global North with Global South targets. The theoretical framework of the course includes, among others approaches from cultural psychological (Valsiner), critical...

Low Temperature Plasma Medicine

Science.gov (United States)

Graves, David

2013-10-01

Ionized gas plasmas near room temperature are used in a remarkable number of technological applications mainly because they are extraordinarily efficient at exploiting electrical power for useful chemical and material transformations near room temperature. In this tutorial address, I will focus on the newest area of low temperature ionized gas plasmas (LTP), in this case operating under atmospheric pressure conditions, in which the temperature-sensitive material is living tissue. LTP research directed towards biomedical applications such as sterilization, surgery, wound healing and anti-cancer therapy has seen remarkable growth in the last 3-5 years, but the mechanisms responsible for the biomedical effects have remained mysterious. It is known that LTP readily create reactive oxygen species (ROS) and reactive nitrogen species (RNS). ROS and RNS (or RONS), in addition to a suite of other radical and non-radical reactive species, are essential actors in an important sub-field of aerobic biology termed ``redox'' (or oxidation-reduction) biology. I will review the evidence suggesting that RONS generated by plasmas are responsible for their observed therapeutic effects. Other possible bio-active mechanisms include electric fields, charges and photons. It is common in LTP applications that synergies between different mechanisms can play a role and I will review the evidence for synergies in plasma biomedicine. Finally, I will address the challenges and opportunities for plasma physicists to enter this novel, multidisciplinary field.

DNA repair is indispensable for survival after acute inflammation

Science.gov (United States)

Calvo, Jennifer A.; Meira, Lisiane B.; Lee, Chun-Yue I.; Moroski-Erkul, Catherine A.; Abolhassani, Nona; Taghizadeh, Koli; Eichinger, Lindsey W.; Muthupalani, Sureshkumar; Nordstrand, Line M.; Klungland, Arne; Samson, Leona D.

2012-01-01

More than 15% of cancer deaths worldwide are associated with underlying infections or inflammatory conditions, therefore understanding how inflammation contributes to cancer etiology is important for both cancer prevention and treatment. Inflamed tissues are known to harbor elevated etheno-base (ε-base) DNA lesions induced by the lipid peroxidation that is stimulated by reactive oxygen and nitrogen species (RONS) released from activated neutrophils and macrophages. Inflammation contributes to carcinogenesis in part via RONS-induced cytotoxic and mutagenic DNA lesions, including ε-base lesions. The mouse alkyl adenine DNA glycosylase (AAG, also known as MPG) recognizes such base lesions, thus protecting against inflammation-associated colon cancer. Two other DNA repair enzymes are known to repair ε-base lesions, namely ALKBH2 and ALKBH3; thus, we sought to determine whether these DNA dioxygenase enzymes could protect against chronic inflammation-mediated colon carcinogenesis. Using established chemically induced colitis and colon cancer models in mice, we show here that ALKBH2 and ALKBH3 provide cancer protection similar to that of the DNA glycosylase AAG. Moreover, Alkbh2 and Alkbh3 each display apparent epistasis with Aag. Surprisingly, deficiency in all 3 DNA repair enzymes confers a massively synergistic phenotype, such that animals lacking all 3 DNA repair enzymes cannot survive even a single bout of chemically induced colitis. PMID:22684101

Considerations on the surgical treatment of Duct Carcinoma in Situ (DCIS) of the breast from DRG system perspective.

Science.gov (United States)

Nistor-Ciurba, Codruţ Cosmin; Cheptea, Marilena

2014-01-01

Medical services for the treatment of Duct Carcinoma In Situ (DCIS) may be delivered in inpatient or outpatient care conditions. The aim of this study was to identify services recommended during patient hospitalization, and those more suitable for outpatient health care services, as well as measures to optimize the management of these cases from the reimbursement of medical services system perspective. We conducted our study on the case records of the Oncological Institute "Prof. Dr. Ion Chiricuţă" Cluj-Napoca (IOCN) over a period of five years (2008-2012). Analysis of the 129 cases of patient hospitalization showed that for the mastectomies performed the mean relative value (VR) for the discharged cases was slightly greater that the referential VR stated in the reimbursement framework contract (VR for IOCN discharged case was 1.2529 vs. 1.2097 referential VR in the contract). VR for the cases discharged after hospitalization in which a local excision had been performed was 0.6778 compared to 0.5482 the referential VR from the reimbursement contract. In the same period, the entity-specific flat-rate reimbursement for local excisions varied from 539 RON to 360 RON, depending on the year. Our study concludes that the treatment of DCIS cases did not negatively influence IOCN funding. In addition, it recommends the negotiation of combined services packages for the lesions that require imaging localization.

Proteomic and carbonylation profile analysis of rat skeletal muscles following acute swimming exercise.

Directory of Open Access Journals (Sweden)

Francesca Magherini

Full Text Available Previous studies by us and other groups characterized protein expression variation following long-term moderate training, whereas the effects of single bursts of exercise are less known. Making use of a proteomic approach, we investigated the effects of acute swimming exercise (ASE on protein expression and carbonylation patterns in two hind limb muscles: the Extensor Digitorum Longus (EDL and the Soleus, mostly composed of fast-twitch and slow-twitch fibres, respectively. Carbonylation is one of the most common oxidative modifications of proteins and a marker of oxidative stress. In fact, several studies suggest that physical activity and the consequent increase in oxygen consumption can lead to increase in reactive oxygen and nitrogen species (RONS production, hence the interest in examining the impact of RONS on skeletal muscle proteins following ASE. Results indicate that protein expression is unaffected by ASE in both muscle types. Unexpectedly, the protein carbonylation level was reduced following ASE. In particular, the analysis found 31 and 5 spots, in Soleus and EDL muscles respectively, whose carbonylation is reduced after ASE. Lipid peroxidation levels in Soleus were markedly reduced as well. Most of the decarbonylated proteins are involved either in the regulation of muscle contractions or in the regulation of energy metabolism. A number of hypotheses may be advanced to account for such results, which will be addressed in future studies.

Metropolitan Washington Airports Policy Supplement to the August 1980 Environmental Impact Statement.

Science.gov (United States)

1981-09-01

along with the recognition of some significant facility and environmental problems that have developed at Washington National Airport. These problems at...large store 53 Window air conditioner 55 Conversational speech 60 Household department of large store 62 Busy restaurant 65 Typing pool (9 typewriters...O 𔃾TONLAIPR 72 nB INL EET OSECNT1R RonNORTH AN SOT ARRIV., A.S V " -’V " - ’ - ’ , "% , . * - 7’ II J . .. ALEXA DRIA ; -" -. "- .". .. -,. - " " J

Scientology

OpenAIRE

Brejnrod, Tobias; Jakobsen, Maj-Britt; Ravn, Sidsel; Stürup, Maja Møller; Flyckt, Nicole

2009-01-01

This study treats Scientology and its characteristics as a religion. Why Scientology’s emergence was possible in USA in the 1950’s are accounted for, and so are the circumstances that made attracting followers possible. Scientology, including Dianetics and the founder, L. Ron Hubbard, is presented. Societal tendencies in USA in the 1950’s are accounted for, and the theory of the Frankfurt School is presented. This results in a discussion of Scientology’s emergence based on societal tendencies...

Dynamics for Robot Control: Friction Modeling and Ensuring Excitation During Parameter Identification

Science.gov (United States)

1988-05-01

degree of Doctor of Philosophy. Gene F. Franklin (Principle Advisor ) I certify that I have read this thesis and that in my opinion it is fully adequate...Ron Crampton, Al Gloor, Charles Lang, Phil Pfenniger and John Truell. It was my great fortune to connect with my advisors , Professors Thomas Binford...especially grateful: it will stand me in good stead. It was not purely by luck that I spent my time at Stanford working with such cool guys and robo jocks

Do gas seepage sites support distinct macrofaunal community ? - An observation in the tropical shelf region of Goa, Arabian Sea, India

Digital Repository Service at National Institute of Oceanography (India)

Harkantra, S.N.; Nagvenkar, S.S.

. In Proceedings of International Seminar on Frontiers of Basic and Applied Molec u- lar Biology, India, 2005, pp. 64 ? 71. 2. Green, J. L. et al. , Spatial scaling of microbial eukaryote d i versity. Nature , 2004, 432 , 747 ? 750. 3. Entcheva, P... in bulk and maize rhizosphere soil in the tro - pics. Appl. Env i ron. Microbiol. , 2003, 69 , 3758 ? 3766. 7. Ward, D. M., Weller, R. and Bateson, M. M., Sequences reveal numerous uncultured microorgan isms in a natural community. N a- ture , 1990...

European contribution to the study of ROS

DEFF Research Database (Denmark)

Egea, Javier; Fabregat, Isabel; Frapart, Yves M

2017-01-01

of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still...... generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination...

Spatial dependence and origin of the ambient doce due to neutron activation processes in linear accelerators

International Nuclear Information System (INIS)

Ruiz Egea, E.; Sanchez Carrascal, M.; Torres Pozas, S.; Monja Ray, P. de la; Perez Molina, J. L.; Madan Rodriguez, C.; Luque Japon, L.; Morera Molina, A.; Hernandez Perez, A.; Barquero Bravo, Y.; Morengo Pedagna, I.; Oliva Gordillo, M. C.; Martin Olivar, R.

2011-01-01

In order to try to determine the high dose in the bunker of a Linear Accelerator clinical use trying to measure the spatial dependence of the sane f ron the isocenter to tite gateway to the Board ceeking to establich the origin of it. This doce measurements performed with an ionization charober at different locations incide the bunker after an irradiation of 400 Monitor Units verifying the doce rate per minute for an hour, and accumulating the doce received during that period of time.

New experience in the process of facing the past

Directory of Open Access Journals (Sweden)

Gajicki Marija

2004-01-01

Full Text Available In this paper the author presents the project VIVISECT, which was developed in connection to the negative reactions in several towns in Serbia to the exhibition of war photography of American photographer Ron Haviv. NGO Vojvodjanka organized the same exhibition in different way, which included removing the titles and allowing people to write their own titles and comments. As a result of that the book and documentary film VIVISECT are developed, which have been afterwards used for developing discussion about the past within community.

Animal welfare in brown trout farming: hematological results

Directory of Open Access Journals (Sweden)

G. Forneris

2010-01-01

Full Text Available The effect of stress resulting from fish farming has received considerable attention in this last period and fish welfare in aquaculture is a relevant topic, very important for the future of aquaculture (Watson et al., 2004; Klinger et al., 1996; Peres et al., 2004; Ron et al., 1995;Wagner et al., 1995;Watson et al., 1998. Brown trout farming is less developed then rainbow trout farming, but this kind of fish farming is increasing, mainly for fish conservation and restocking aquaculture.

Psicofísica de los tiempos de reacción: teorías y métodos

OpenAIRE

Claude Bonnet

1994-01-01

Se presentan los métodos clásicos para estudiar los tiempos de reacción, primero en su perspectiva clásica, basada en Donders, como una forma de explorar los pasos sucesivos del procesamiento de información. En segundo lugar se muestra su utilización en las escalas psicofísicas (ley de Piéron). En tercer lugar, se enfatiza su importancia como modelo de producción de respuestas, que permite separar los componentes decisionales y sensoriales de la respuesta

Managing an outpatient parenteral antibiotic therapy team: challenges and solutions

Directory of Open Access Journals (Sweden)

Halilovic J

2014-06-01

Full Text Available Jenana Halilovic,1 Cinda L Christensen,2 Hien H Nguyen31University of the Pacific Thomas J Long School of Pharmacy, Stockton, CA, USA; 2Department of Pharmaceutical Services, University of California, Davis Health System, Sacramento, CA, USA; 3Division of Infectious Diseases, Section of Hospital Medicine, University of California, Davis Health System, Sacramento, CA, USAAbstract: Outpatient parenteral antimicrobial therapy (OPAT programs should strive to deliver safe, cost effective, and high quality care. One of the keys to developing and sustaining a high quality OPAT program is to understand the common challenges or barriers to OPAT delivery. We review the most common challenges to starting and managing an OPAT program and give practical advice on addressing these issues.Keywords: OPAT, quality, safety, program management

Taxonomic notes on the species of the genus Anterhynchium de Saussure, 1863 (Hymenoptera: Vespidae: Eumeninae) from Vietnam, with description of a new species.

Science.gov (United States)

Nguyen, Lien Thi Phuong

2015-02-02

A taxonomic study on the solitary wasps in the vespid genus Anterhynchium de Saussure, 1863, from Vietnam is presented. One species previously identified as A. (Anterhynchium) abdominale abdominale (Illiger, 1802) is described as new, namely A. punctatum Nguyen, sp. nov. Antechynchium (Dirhynchium) flavolineatum flavolineatum (Smith, 1857) and A. (Dirhynchium) flavomarginatum flavomarginatum (Smith, 1852) are newly recorded from Vietnam. New synonymy is proposed for A. flavolineatum flavolineatum (Smith, 1857) =A. flavolineatum malaisei van der Vecht, 1963, syn. nov. A. coracinum van der Vecht sensu Girish Kumar (2013) is a misidentification of A. f. flavomarginatum (Smith), and the record of this species from Pakistan and India belongs to A. f. flavolineatum. A key to species of the genus from Vietnam is provided. 

HUBUNGAN SENSISTIVITAS PLASMODIUM FALCIPARUM TERHADAP KOMBINASI PIRIMETAMIN/SULFADOKSIN DAN KLOROKUIN SECARA IN VITRO

Directory of Open Access Journals (Sweden)

Sahat Ompusunggu

2012-09-01

Full Text Available An in vitro sensitivity test was conducted to study the sensitivity of Plasmodium falciparum against chloroquine and pyrimethamine/sulphadoxine combination. The relationship between sensitivity of the parasite to the two drugs was also studied. A total of 72 patients from five localities were examined during 1984-1985. Test against chloroquine was conduc­ted according to WHO method, while against pyrimethamine/sulphadoxine combination, a modified method of Nguyen Dinh and Payne and Eastham and Rieckmann was used. The results showed that there is no relationship between the sensitivity of P. falciparum against pyrimethamine/ sulphadoxine combination and chloroquine. It can be concluded that in case of chloroquine resistant P. falciparum, pyrimethamine/sulphadoxine combination could be applied as an alternative chemotherapy.

Can scholarship in nursing/midwifery education result in a successful research career?

Science.gov (United States)

Cooper, Simon; Absalom, Irene; Cant, Robyn; Bogossian, Fiona; Kelly, Michelle; Levett-Jones, Tracy; McKenna, Lisa

2018-05-07

In a recent editorial we examined the research outputs of 150 Australian nursing and midwifery professors (McKenna, Cooper, Cant, Bogossian, 2017) identifying publication metrics on par with, and sometimes above those of professors in the UK (Watson, McDonagh & Thompson, 2016). Because global university rankings are heavily weighted towards research, there has been pressure on universities and on academics to maximise research performance (Nguyen, Rambaldi & Tang, 2017). Although many Australian universities have increasingly focused on education delivery, and despite the need for a strong evidence base for learning and teaching, academics are often cautioned against focusing too heavily on educational research. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Procedure for Installing a photovoltaic system on roofs in Cuban Ron Corporation S.A

International Nuclear Information System (INIS)

Guzmán Villavicencio, Mayra; Águila Bernal, Inoel; Torres Águila, José M.; Soto Castellón, Carlos R.

2017-01-01

In this work, a methodological procedure developed from experiences gained during the project "Photovoltaic installation on the roofs of the Central Rum Factory for operation in self consumption and public MT grid connection” is presented, which was held along with UGAO-AINAIR signature. It is developed taking into account the need to further consolidate the dominance of this alternative energy technology, which is the first experience in such facilities for both, the rum industry and process industries in Cuba. There are no technical rules that regulate requirements to be considered during the conceptual stage of projects for the introduction of photovoltaic systems connected to the grid. The methodological procedure presented provides guidance for its application in other entities, resulting necessary its elaboration to ensure technical stability and reliability of systems during its life. (author)

Sociology of Writer as the Basic Element to Comprehend D.zawawi Im-ron's Poems

OpenAIRE

Harits, Imron Wakhid

2015-01-01

D.Zawawi Imron is one of an outstanding poet in Indonesia with his contemporary poems style. His life background, his culture, and his place where he lives are much affected to his works. This study is aimed to observe the influence of his life background to comprehend his works focusing on D. zawawi Imron poems. Because it is hard to comprehend and understand the messages and also the contents of his poems without observing his life background in Madura. His cultural identity as Madura peopl...

Production of gasoline fraction from bio-oil under atmospheric conditions by an integrated catalytic transformation process

International Nuclear Information System (INIS)

Zhang, Zhaoxia; Bi, Peiyan; Jiang, Peiwen; Fan, Minghui; Deng, Shumei; Zhai, Qi; Li, Quanxin

2015-01-01

This work aimed to develop an integrated process for production of gasoline fraction bio-fuels from bio-oil under atmospheric conditions. This novel transformation process included the catalytic cracking of bio-oil to light olefins and the subsequent synthesis of liquid hydrocarbon bio-fuels from light olefins with two reactors in series. The yield of bio-fuel was up to 193.8 g/(kg bio-oil) along with a very low oxygen content, high RONs (research octane numbers), high LHVs (lower heating values) and low benzene content under the optimizing reaction conditions. Coke deposition seems to be the main cause of catalyst deactivation in view of the fact that the deactivated catalysts was almost recovered by on-line treating the used catalyst with oxygen. The integrated transformation potentially provides a useful way for the development of gasoline range hydrocarbon fuels using renewable lignocellulose biomass. - Graphical abstract: An integrated process for production of gasoline fraction bio-fuels from bio-oil through the catalytic cracking of bio-oil to light olefins followed by the synthesis of liquid hydrocarbon bio-fuels from light olefins in series. - Highlights: • A new route for production of gasoline-range bio-fuels from bio-oil was achieved. • The process was an integrated catalytic transformation at atmospheric pressure. • Bio-oil is converted into light olefins and then converted to biofuel in series. • C_6–C_1_0 bio-fuels derived from bio-oil had high RONs and LHVs.

Outcomes and Recommendations of an Indian Expert Panel for Improved Practice in Controlled Ovarian Stimulation for Assisted Reproductive Technology

Directory of Open Access Journals (Sweden)

Baiju Ahemmed

2017-01-01

Full Text Available Purpose. To improve success of in vitro fertilization (IVF, assisted reproductive technology (ART experts addressed four questions. What is optimum oocytes number leading to highest live birth rate (LBR? Are cohort size and embryo quality correlated? Does gonadotropin type affect oocyte yield? Should “freeze-all” policy be adopted in cycles with progesterone >1.5 ng/mL on day of human chorionic gonadotropin (hCG administration? Methods. Electronic database search included ten studies on which panel gave opinions for improving current practice in controlled ovarian stimulation for ART. Results. Strong association existed between retrieved oocytes number (RON and LBRs. RON impacted likelihood of ovarian hyperstimulation syndrome (OHSS. Embryo euploidy decreased with age, not with cohort size. Progesterone > 1.5 ng/dL did not impair cycle outcomes in patients with high cohorts and showed disparate results on day of hCG administration. Conclusions. Ovarian stimulation should be designed to retrieve 10–15 oocytes/treatment. Accurate dosage, gonadotropin type, should be selected as per prediction markers of ovarian response. Gonadotropin-releasing hormone (GnRH antagonist based protocols are advised to avoid OHSS. Cumulative pregnancy rate was most relevant pregnancy endpoint in ART. Cycles with serum progesterone ≥1.5 ng/dL on day of hCG administration should not adopt “freeze-all” policy. Further research is needed due to lack of data availability on progesterone threshold or index.

Synergistic Effect of H2O2 and NO2 in Cell Death Induced by Cold Atmospheric He Plasma

Science.gov (United States)

Girard, Pierre-Marie; Arbabian, Atousa; Fleury, Michel; Bauville, Gérard; Puech, Vincent; Dutreix, Marie; Sousa, João Santos

2016-01-01

Cold atmospheric pressure plasmas (CAPPs) have emerged over the last decade as a new promising therapy to fight cancer. CAPPs’ antitumor activity is primarily due to the delivery of reactive oxygen and nitrogen species (RONS), but the precise determination of the constituents linked to this anticancer process remains to be done. In the present study, using a micro-plasma jet produced in helium (He), we demonstrate that the concentration of H2O2, NO2− and NO3− can fully account for the majority of RONS produced in plasma-activated buffer. The role of these species on the viability of normal and tumour cell lines was investigated. Although the degree of sensitivity to H2O2 is cell-type dependent, we show that H2O2 alone cannot account for the toxicity of He plasma. Indeed, NO2−, but not NO3−, acts in synergy with H2O2 to enhance cell death in normal and tumour cell lines to a level similar to that observed after plasma treatment. Our findings suggest that the efficiency of plasma treatment strongly depends on the combination of H2O2 and NO2− in determined concentrations. We also show that the interaction of the He plasma jet with the ambient air is required to generate NO2− and NO3− in solution. PMID:27364563

Terpineol as a novel octane booster for extending the knock limit of gasoline

KAUST Repository

Vallinayagam, R.

2016-09-16

Improving the octane number of gasoline offers the potential of improved engine combustion, as it permits spark timing advancement without engine knock. This study proposes the use of terpineol as an octane booster for gasoline in a spark ignited (SI) engine. Terpineol is a bio-derived oxygenated fuel obtained from pine tree resin, and has the advantage of higher calorific value than ethanol. The ignition delay time (IDT) of terpineol was first investigated in an ignition quality tester (IQT). The IQT results demonstrated a long ignition delay of 24.7 ms for terpineol and an estimated research octane number (RON) of 104, which was higher than commercial European (Euro V) gasoline. The octane boosting potential of terpineol was further investigated by blending it with a non-oxygenated gasoline (FACE F), which has a RON (94) lower than Euro V gasoline (RON = 97). The operation of a gasoline direct injection (GDI) SI engine fueled with terpineol-blended FACE F gasoline enabled spark timing advancement and improved engine combustion. The knock intensity of FACE F + 30% terpineol was lower than FACE F gasoline at both maximum brake torque (MBT) and knock limited spark advance (KLSA) operating points. Increasing proportions of terpineol in the blend caused peak heat release rate, in-cylinder pressure, CA50, and combustion duration to be closer to those of Euro V gasoline. Furthermore, FACE F + 30% terpineol displayed improved combustion characteristics when compared to Euro V gasoline. © 2016

Modeling of Heating and Evaporation of FACE I Gasoline Fuel and its Surrogates

KAUST Repository

Elwardani, Ahmed Elsaid

2016-04-05

The US Department of Energy has formulated different gasoline fuels called \\'\\'Fuels for Advanced Combustion Engines (FACE)\\'\\' to standardize their compositions. FACE I is a low octane number gasoline fuel with research octane number (RON) of approximately 70. The detailed hydrocarbon analysis (DHA) of FACE I shows that it contains 33 components. This large number of components cannot be handled in fuel spray simulation where thousands of droplets are directly injected in combustion chamber. These droplets are to be heated, broken-up, collided and evaporated simultaneously. Heating and evaporation of single droplet FACE I fuel was investigated. The heating and evaporation model accounts for the effects of finite thermal conductivity, finite liquid diffusivity and recirculation inside the droplet, referred to as the effective thermal conductivity/effective diffusivity (ETC/ED) model. The temporal variations of the liquid mass fractions of the droplet components were used to characterize the evaporation process. Components with similar evaporation characteristics were merged together. A representative component was initially chosen based on the highest initial mass fraction. Three 6 components surrogates, Surrogate 1-3, that match evaporation characteristics of FACE I have been formulated without keeping same mass fractions of different hydrocarbon types. Another two surrogates (Surrogate 4 and 5) were considered keeping same hydrocarbon type concentrations. A distillation based surrogate that matches measured distillation profile was proposed. The calculated molar mass, hydrogen-to-carbon (H/C) ratio and RON of Surrogate 4 and distillation based one are close to those of FACE I.

Outcomes and Recommendations of an Indian Expert Panel for Improved Practice in Controlled Ovarian Stimulation for Assisted Reproductive Technology

Science.gov (United States)

Ahemmed, Baiju; Sundarapandian, Vani; Gutgutia, Rohit; Balasubramanyam, Sathya; Jagtap, Richa; Biliangady, Reeta; Gupta, Priti; Jadhav, Sachin; Satwik, Ruma; Thakor, Priti

2017-01-01

Purpose. To improve success of in vitro fertilization (IVF), assisted reproductive technology (ART) experts addressed four questions. What is optimum oocytes number leading to highest live birth rate (LBR)? Are cohort size and embryo quality correlated? Does gonadotropin type affect oocyte yield? Should “freeze-all” policy be adopted in cycles with progesterone >1.5 ng/mL on day of human chorionic gonadotropin (hCG) administration? Methods. Electronic database search included ten studies on which panel gave opinions for improving current practice in controlled ovarian stimulation for ART. Results. Strong association existed between retrieved oocytes number (RON) and LBRs. RON impacted likelihood of ovarian hyperstimulation syndrome (OHSS). Embryo euploidy decreased with age, not with cohort size. Progesterone > 1.5 ng/dL did not impair cycle outcomes in patients with high cohorts and showed disparate results on day of hCG administration. Conclusions. Ovarian stimulation should be designed to retrieve 10–15 oocytes/treatment. Accurate dosage, gonadotropin type, should be selected as per prediction markers of ovarian response. Gonadotropin-releasing hormone (GnRH) antagonist based protocols are advised to avoid OHSS. Cumulative pregnancy rate was most relevant pregnancy endpoint in ART. Cycles with serum progesterone ≥1.5 ng/dL on day of hCG administration should not adopt “freeze-all” policy. Further research is needed due to lack of data availability on progesterone threshold or index. PMID:28246628

Phase 2 Remedial Investigation Report Army Materials Technology Laboratory, Task Order 1 Remedial Investigation/Feasibility Study, Volume 5 - Appendices K-V

Science.gov (United States)

1994-05-01

c I LR lb f A SOREMEDE;-7.1. FT. BELW GROUNO SURFACE AmW&.L DOrM A_. A -- W OP YC ASMa m 3t ,€, .Ea&A1roN off ToPF P C VML CAMN,A Fr. AMSL GR...All wells contained greater than 10 mg/L nitrate-nitrogen. In 214 cases of infantile methemoglobinemia, Walton I et al., (1951) reported all were due...based on the NOAELUof 10 mg/L nitrate-nitrogen for infantile methemoglobinemia as reported by Bosch et al., (1950) and Walton (1951). The NOAEL was

La mise en tourisme de l'Ardenne belge (1850-1914) Genèse et évolution d'un espace touristique. Processus, acteurs et territoires.

OpenAIRE

Quériat, Stéphanie

2010-01-01

Ce travail sur la mise en tourisme de l’Ardenne se veut une première pierre sur laquelle, nous l’espérons, des recherches ultérieures, relatives à l’Ardenne mais aussi à d’autres espaces, pourront venir s’appuyer mais aussi se confronter. Pour poser les fondements, il fallait tenir compte du système touristique dans son ensemble et l’attaquer sur plusieurs fronts :celui des représentations, de la perception, celui correspondant à la réalité plus physique du territoire, celui de ses acteurs et...

Grupo Archigram, 1961-1974.Uma Fábula da técnica

OpenAIRE

Pianta Costa Cabral, Claudia

2002-01-01

El tema de esta tesis es la producción del grupo inglés Archigram, constituido por Peter Cook (1936), Warren Chalk (1927-1987), Ron Herron (1930-1994), Dennis Crompton (1935), Michael Webb (1937) y David Greene (1937), articulado alrededor a la revista homónima publicada en Londres entre 1961 y 1974 (diez números). Dicha producción por lo tanto no consiste en obras construidas, pero en el conjunto de los proyectos, dibujos y textos desarrollados en estos años por los miembros del grupo, indi...

Oportunidades y retos para Diageo con la firma del TLC Colombia- Unión Europea

OpenAIRE

Joya Shaker, Mónica; Afanador Forero, Juan Camilo

2013-01-01

Diageo es la multinacional líder en producción y comercialización de bebidas espirituosas Premium y cuenta con presencia en más de 80 países incluyendo Colombia, donde la industria de licores presenta una tendencia creciente consecuente con el crecimiento económico del país. Dentro de este contexto, la categoría de bebidas espirituosas juega el papel principal con productos como ron, whisky y aguardiente, con la mayoría de la participación en el mercado nacional. Sin embargo, existe en est...

What’s Next: The Status of ISO Global KM Standards and the Importance of Managing Knowledge Assets

International Nuclear Information System (INIS)

Young, R.

2016-01-01

Full text: Ron Young, CEO of Knowledge Associates International, based in Cambridge UK, is Chair of the BSI KM Standards Committee KMS/1, member of the BSI Asset Management Committee AMS/1 working with ISO 55000, and member of the ISO 30401 workgroup developing a global KM Standard. He will present the benefits, challenges and implications of a global KM standard, from his perspective, and give an update on the ISO/BSI standard development. He will also provide insights into the latest developments with knowledge asset management. (author

Geothermal power plants principles, applications, case studies and environmental impact

CERN Document Server

DiPippo, Ronald

2008-01-01

Ron DiPippo, Professor Emeritus at the University of Massachusetts Dartmouth, is a world-regarded geothermal expert. This single resource covers all aspects of the utilization of geothermal energy for power generation from fundamental scientific and engineering principles. The thermodynamic basis for the design of geothermal power plants is at the heart of the book and readers are clearly guided on the process of designing and analysing the key types of geothermal energy conversion systems. Its practical emphasis is enhanced by the use of case studies from real plants that increase the reader'