WorldWideScience

Sample records for next-generation lighting applications

  1. Next Generation Light Robotics

    DEFF Research Database (Denmark)

    Glückstad, Jesper

    Light Robotics is a new field of research where ingredients from photonics, nanotechnology and biotechnology are put together in new ways to realize light-driven robotics at the smallest scales to solve major challenges primarily within the nanobio-domain but not limited hereto. Exploring the full...... potential of this new ‘drone-like’ light-printed, light-driven, light-actuated micro- and nano-robotics in challenging geometries requires a versatile and real-time reconfigurable light addressing that can dynamically track a plurality of tiny tools in 3D to ensure real-time continuous light...

  2. The next generation of ultraviolet light technologies

    International Nuclear Information System (INIS)

    Roy, K.A.

    1990-01-01

    According to this article, the next generation of ultraviolet (UV) light technologies into the environmental spotlight. Researchers have long recognized the potential of UV light, nestled between the longer radiation wavelengths of the visible spectrum and the shorter ones in the x-ray region, to effect chemical change. Environmentally, UV light made its debut as a water purification tool. As the technology improved, researchers incorporated UV light in wastewater treatment systems and, later, in remediation techniques

  3. Synchronization System for Next Generation Light Sources

    Energy Technology Data Exchange (ETDEWEB)

    Zavriyev, Anton [MagiQ Technologies, Inc., Somerville, MA (United States)

    2014-03-27

    An alternative synchronization technique – one that would allow explicit control of the pulse train including its repetition rate and delay is clearly desired. We propose such a scheme. Our method is based on optical interferometry and permits synchronization of the pulse trains generated by two independent mode-locked lasers. As the next generation x-ray sources will be driven by a clock signal derived from a mode-locked optical source, our technique will provide a way to synchronize x-ray probe with the optical pump pulses.

  4. Permanent magnet based dipole magnets for next generation light sources

    Directory of Open Access Journals (Sweden)

    Takahiro Watanabe

    2017-07-01

    Full Text Available We have developed permanent magnet based dipole magnets for the next generation light sources. Permanent magnets are advantageous over electromagnets in that they consume less power, are physically more compact, and there is a less risk of power supply failure. However, experience with electromagnets and permanent magnets in the field of accelerators shows that there are still challenges to replacing main magnets of accelerators for light sources with permanent magnets. These include the adjustability of the magnetic field, the temperature dependence of permanent magnets, and the issue of demagnetization. In this paper, we present a design for magnets for future light sources, supported by experimental and numerical results.

  5. A Next Generation Light Source Facility at LBNL

    International Nuclear Information System (INIS)

    Corlett, J.N.; Austin, B.; Baptiste, K.M.; Byrd, J.M.; Denes, P.; Donahue, R.; Doolittle, L.; Falcone, R.W.; Filippetto, D.; Fournier, S.; Li, D.; Padmore, H.A.; Papadopoulos, C.; Pappas, C.; Penn, G.; Placidi, M.; Prestemon, S.; Prosnitz, D.; Qiang, J.; Ratti, A.; Reinsch, M.; Sannibale, F.; Schlueter, R.; Schoenlein, R.W.; Staples, J.W.; Vecchione, T.; Venturini, M.; Wells, R.; Wilcox, R.; Wurtele, J.; Charman, A.; Kur, E.; Zholents, A.A.

    2011-01-01

    The Next Generation Light Source (NGLS) is a design concept, under development at LBNL, for a multibeamline soft x-ray FEL array powered by a ∼2 GeV superconducting linear accelerator, operating with a 1 MHz bunch repetition rate. The CW superconducting linear accelerator is supplied by a high-brightness, high-repetition-rate photocathode electron gun. Electron bunches are distributed from the linac to the array of independently configurable FEL beamlines with nominal bunch rates up to 100 kHz in each FEL, and with even pulse spacing. Individual FELs may be configured for EEHG, HGHG, SASE, or oscillator mode of operation, and will produce high peak and average brightness x-rays with a flexible pulse format, with pulse durations ranging from sub-femtoseconds to hundreds of femtoseconds.

  6. Prospects for Next-Generation Storage Ring Light Sources

    Science.gov (United States)

    Borland, Michael

    2015-04-01

    Storage ring light sources are among the most productive large-scale scientific user facilities in existence, owing to a combination of broad tunability, mature technology, high capacity, remarkable reliability, and high performance. The most commonly-used performance measure is the photon beam brightness, which is proportional to the flux per unit volume in six-dimensional phase space. The brightness is generally maximized by minimizing the transverse phase space area, or emittance, of the electron beam that generates the photons. Since the 1990's, most storage ring light sources have used a variant of the Chasman-Green, or double-bend-achromat (DBA), lattice, which produces transverse emittances of several nanometers. Presently, several light sources are under construction based on more challenging multi-bend-achromat (MBA) concepts, which promise an order of magnitude reduction in the emittance. Somewhat larger reductions are contemplated for upgrades of the largest facilities. This talk briefly surveys the relevant concepts in light source design, then explains both the mechanism and challenge of achieving next-generation emittances. Other factors, such as improved radiation-emitting devices, are also described. Work supported by the U.S. Department of Energy, Office of Science, under Contract No. DE-AC02-06CH11357.

  7. DARC: Next generation decentralized control framework for robot applications

    DEFF Research Database (Denmark)

    Kjærgaard, Morten; Andersen, Nils Axel; Ravn, Ole

    2013-01-01

    This paper presents DARC, a next generation control framework for robot applications. It is designed to be equally powerful in prototyping research projects and for building serious commercial robots running on low powered embedded hardware, thus closing the gab between research and industry...

  8. NEXT-GENERATION GENE SEQUENCING AND ITS APPLICATIONS IN ONCOHEMATOLOGY

    Directory of Open Access Journals (Sweden)

    I. M. Barkhatov

    2016-01-01

    Full Text Available The review bears on basic principles and technologies of next-generation sequencing (NGS, as well as its applications for detection of gene mutations in leukemic cells. We discuss some novel data concerning NGS approach to studies of genetic heterogeneity in myeloproliferative disorders, detection of high-risk genes, including drug resistance mutations, epigenomic changes associated with leukemias, as well as molecular aspects of clonal evolution. A special section concerns basic problems with bioinformatics and adequate analysis of large digital databases obtained with NGS approach. Optimal choice of appropriate software is of utmost importance for adequate retrieval and interpretation of the NGS data.

  9. Diamond Light Source - A Next Generation SR Facility

    International Nuclear Information System (INIS)

    Materlik, G.

    2004-01-01

    After the very successful start and the by now almost 10 years operation of the 3rd generation x-ray sources ESRF, APS and Spring-8 smaller storage rings are being planned and constructed with properties emphasising applications with photon energies around the 10 keV spectral region. In the UK the Government and the medical foundation Wellcome Trust have decided to build the Diamond Light Source Facility in the South of Oxfordshire right next to the Rutherford Appleton Laboratory. The joint venture company Diamond Light Source Limited has been created to plan, construct, and operate this facility. (author)

  10. Next Generation Luminaires: Recognizing Innovative, Energy-Efficient Commercial Lighting Luminaires

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-04-01

    Fact sheet that describes the Next Generation Luminaires SSL lighting design competition, which recognizes excellence in technical innovation and design of high-quality, energy-efficient commercial lighting, both indoor and outdoor.

  11. Application of Next-generation Sequencing in Clinical Molecular Diagnostics

    Directory of Open Access Journals (Sweden)

    Morteza Seifi

    2017-05-01

    Full Text Available ABSTRACT Next-generation sequencing (NGS is the catch all terms that used to explain several different modern sequencing technologies which let us to sequence nucleic acids much more rapidly and cheaply than the formerly used Sanger sequencing, and as such have revolutionized the study of molecular biology and genomics with excellent resolution and accuracy. Over the past years, many academic companies and institutions have continued technological advances to expand NGS applications from research to the clinic. In this review, the performance and technical features of current NGS platforms were described. Furthermore, advances in the applying of NGS technologies towards the progress of clinical molecular diagnostics were emphasized. General advantages and disadvantages of each sequencing system are summarized and compared to guide the selection of NGS platforms for specific research aims.

  12. Application of photonics in next generation telecommunication satellites payloads

    Science.gov (United States)

    Anzalchi, J.; Inigo, P.; Roy, B.

    2017-11-01

    Next generation broadband telecommunication satellites are required to provide very high data throughput using complex multibeam architectures. These high throughput `Terabit/s' Satellites will incorporate payloads with very large quantity of conventional RF equipment, co-axial cables, waveguides, harnesses and ancillary equipment, making the Assembly, Integration and Test (AIT) very complex. Use of `RF over Fiber' and associated photonics equipment can make the process of AIT much simpler with the added benefit of significant reduction in number of payload equipment and inherent payload mass.

  13. Application of Next Generation Sequencing on Genetic Testing

    DEFF Research Database (Denmark)

    Li, Jian

    developed a targeted sequencing based preimplantation genetic diagnosis (PGD) method for monogenic diseases and tested it in a family suffering from β-thalassaemia major undergoing PGD. Moreover, we developed a method which can achieve detection of point mutation and copy number variation simultaneously......The discovery of genetic factors behind increasing number of human diseases and the growth of education of genetic knowledge to the public make demands for genetic testing increase rapidly. However, traditional genetic testing methods cannot meet all kinds of the requirements. Next generation...... sequencing (NGS) featured with high throughput and low cost of sequencing capacity develops fast, especially with the improvement of its read length, read accuracy and the immergence of small-sized machines, making it a powerful genetic testing tool. In this study, we applied NGS to develop novel genetic...

  14. Implementing Value Added Applications in Next Generation Networks

    Directory of Open Access Journals (Sweden)

    Yuan-Kuang Tu

    2010-08-01

    Full Text Available One of the major issues in the future Internet is the integration of telecom networks with the Internet. In many countries, large Internet Service Providers (ISPs are also telecom operators that have been focusing on providing Internet services through their telecom networks with telecom-grade mechanisms. In this article, we show that IP Multimedia Subsystem (IMS is a telecom-grade mechanism that addresses this important issue. In Next Generation Network (NGN, IMS supports IP-based multimedia services that can be accessed from various wireless and wired access technologies through fixed-mobile convergence. We show how to integrate Internet Protocol Television (IPTV with NGN/IMS to offer enhanced IPTV services for subscribers with set-top boxes or mobile phones. We specifically describe the implementations of three services: weather forecasts, short messages on TV screens and TV shopping/food ordering for mobile users. Although these services can be directly implemented in the Internet, our commercial operation experiences indicate that the NGN/IMS implementation has advantages in terms of telecom-grade security, Quality of Service (QoS, and flexible service creation.

  15. Next-generation batteries and fuel cells for commercial, military, and space applications

    CERN Document Server

    Jha, A R

    2012-01-01

    Distilling complex theoretical physical concepts into an understandable technical framework, Next-Generation Batteries and Fuel Cells for Commercial, Military, and Space Applications describes primary and secondary (rechargeable) batteries for various commercial, military, spacecraft, and satellite applications for covert communications, surveillance, and reconnaissance missions. It emphasizes the cost, reliability, longevity, and safety of the next generation of high-capacity batteries for applications where high energy density, minimum weight and size, and reliability in harsh conditions are

  16. Applications of Next-Generation Sequencing Technologies to Diagnostic Virology

    Directory of Open Access Journals (Sweden)

    Giorgio Palù

    2011-11-01

    Full Text Available Novel DNA sequencing techniques, referred to as “next-generation” sequencing (NGS, provide high speed and throughput that can produce an enormous volume of sequences with many possible applications in research and diagnostic settings. In this article, we provide an overview of the many applications of NGS in diagnostic virology. NGS techniques have been used for high-throughput whole viral genome sequencing, such as sequencing of new influenza viruses, for detection of viral genome variability and evolution within the host, such as investigation of human immunodeficiency virus and human hepatitis C virus quasispecies, and monitoring of low-abundance antiviral drug-resistance mutations. NGS techniques have been applied to metagenomics-based strategies for the detection of unexpected disease-associated viruses and for the discovery of novel human viruses, including cancer-related viruses. Finally, the human virome in healthy and disease conditions has been described by NGS-based metagenomics.

  17. Ni-Ti Next Generation Bearings for Space Applications

    Science.gov (United States)

    DellaCorte, Christopher

    2018-01-01

    NASA applications challenge traditional bearing materials. The rigors of launch often include heavy shock loads and exposure to corrosive environments (e.g., salt spray). Unfortunately, ball and roller bearings made from hardened steels are vulnerable to Brinell denting and rust which can limit performance and life. Ceramic materials can eliminate corrosion concerns but their high stiffness and extreme hardness actually makes denting problems worse. In this presentation, an emerging superelastic alloy, NiTi, is introduced for rolling element bearing applications. Through a decade of RD, NiTi alloy bearings have been put through a comprehensive series of life and performance tests. Hardness, corrosion, strength, stiffness, and rolling contact fatigue tests have been conducted and reported. Ball bearings ranging in size from 12 to 50mm bore have been successfully engineered and operated over a wide range of speeds and test conditions including being submerged in water. The combination of high hardness, moderate elastic modulus, low density, and intrinsic corrosion immunity provide new possibilities for mechanisms that operate under extreme conditions. Recent preliminary tests indicate that bearings can be made from NiTi alloys that are easily lubricated by conventional oils and greases and exhibit acceptable rolling contact fatigue resistance. This presentation introduces the NiTi materials systems and shows how NASA is using it to alleviate several specific problems encountered in advanced space applications.

  18. Embedded Thermal Control for Subsystems for Next Generation Spacecraft Applications

    Science.gov (United States)

    Didion, Jeffrey R.

    2015-01-01

    Thermal Fluids and Analysis Workshop, Silver Spring MD NCTS 21070-15. NASA, the Defense Department and commercial interests are actively engaged in developing miniaturized spacecraft systems and scientific instruments to leverage smaller cheaper spacecraft form factors such as CubeSats. This paper outlines research and development efforts among Goddard Space Flight Center personnel and its several partners to develop innovative embedded thermal control subsystems. Embedded thermal control subsystems is a cross cutting enabling technology integrating advanced manufacturing techniques to develop multifunctional intelligent structures to reduce Size, Weight and Power (SWaP) consumption of both the thermal control subsystem and overall spacecraft. Embedded thermal control subsystems permit heat acquisition and rejection at higher temperatures than state of the art systems by employing both advanced heat transfer equipment (integrated heat exchangers) and high heat transfer phenomena. The Goddard Space Flight Center Thermal Engineering Branch has active investigations seeking to characterize advanced thermal control systems for near term spacecraft missions. The embedded thermal control subsystem development effort consists of fundamental research as well as development of breadboard and prototype hardware and spaceflight validation efforts. This paper will outline relevant fundamental investigations of micro-scale heat transfer and electrically driven liquid film boiling. The hardware development efforts focus upon silicon based high heat flux applications (electronic chips, power electronics etc.) and multifunctional structures. Flight validation efforts include variable gravity campaigns and a proposed CubeSat based flight demonstration of a breadboard embedded thermal control system. The CubeSat investigation is technology demonstration will characterize in long-term low earth orbit a breadboard embedded thermal subsystem and its individual components to develop

  19. Applications of nanotechnology, next generation sequencing and microarrays in biomedical research.

    Science.gov (United States)

    Elingaramil, Sauli; Li, Xiaolong; He, Nongyue

    2013-07-01

    Next-generation sequencing technologies, microarrays and advances in bio nanotechnology have had an enormous impact on research within a short time frame. This impact appears certain to increase further as many biomedical institutions are now acquiring these prevailing new technologies. Beyond conventional sampling of genome content, wide-ranging applications are rapidly evolving for next-generation sequencing, microarrays and nanotechnology. To date, these technologies have been applied in a variety of contexts, including whole-genome sequencing, targeted re sequencing and discovery of transcription factor binding sites, noncoding RNA expression profiling and molecular diagnostics. This paper thus discusses current applications of nanotechnology, next-generation sequencing technologies and microarrays in biomedical research and highlights the transforming potential these technologies offer.

  20. Femtosecond timing distribution and control for next generation accelerators and light sources

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Li -Jin [Idesta Quantum Electronics, LLC, Newton, NJ (United States)

    2014-03-31

    Femtosecond Timing Distribution At LCLS Free-electron-lasers (FEL) have the capability of producing high photon flux from the IR to the hard x-ray wavelength range and to emit femtosecond and eventually even attosecond pulses. This makes them an ideal tool for fundamental as well as applied re-search. Timing precision at the Stanford Linear Coherent Light Source (LCLS) between the x-ray FEL (XFEL) and ultrafast optical lasers is currently no better than 100 fs RMS. Ideally this precision should be much better and could be limited only by the x-ray pulse duration, which can be as short as a few femtoseconds. An increasing variety of science problems involving electron and nuclear dynamics in chemical and material systems will become accessible as the timing improves to a few femtoseconds. Advanced methods of electron beam conditioning or pulse injection could allow the FEL to achieve pulse durations less than one femtosecond. The objective of the work described in this proposal is to set up an optical timing distribution system based on mode locked Erbium doped fiber lasers at LCLS facility to improve the timing precision in the facility and allow time stamping with a 10 fs precision. The primary commercial applications for optical timing distributions systems are seen in the worldwide accelerator facilities and next generation light sources community. It is reasonable to expect that at least three major XFELs will be built in the next decade. In addition there will be up to 10 smaller machines, such as FERMI in Italy and Maxlab in Sweden, plus the market for upgrading already existing facilities like Jefferson Lab. The total market is estimated to be on the order of a 100 Million US Dollars. The company owns the exclusive rights to the IP covering the technology enabling sub-10 fs synchronization systems. Testing this technology, which has set records in a lab environment, at LCLS, hence in a real world scenario, is an important corner stone of bringing the

  1. Probing Cherenkov and Scintillation Light Separation for Next-Generation Neutrino Detectors

    Science.gov (United States)

    Caravaca, J.; Descamps, F. B.; Land, B. J.; Orebi Gann, G. D.; Wallig, J.; Yeh, M.

    2017-09-01

    The ability to separate Cherenkov and scintillation signals in liquid scintillator detectors would enable outstanding background rejection for next-generation neutrino experiments. Reconstruction of directional information, ring imaging, and sub-Cherenkov threshold detection all have the potential to substantially improve particle and event identification. The Cherenkov-Scintillation Separation (CHESS) experiment uses an array of small, fast photomultipliers (PMTs) and state-of-the-art electronics to demonstrate the reconstruction of a Cherenkov ring in a scintillation medium based on photon hit times and detected charge. This setup has been used to characterize the ability to detect Cherenkov light in a range of target media. We show results with pure organic scintillator (LAB) and the prospects with scintillators with a secondary fluor (LAB/PPO). There are future plans to deploy the newly developed water-based liquid scintillator, a medium with a higher Cherenkov/Scintillation light yield ratio than conventional pure liquid scintillators, enhancing the visibility of the less abundant Cherenkov light in the presence of scintillation light. These results can inform the development of future large-scale detectors, such as the proposed Theia experiment, or other large detectors at underground laboratories such as the far-site of the new Long Baseline Neutrino Facility at the Sanford Underground Research Facility. CHESS detector calibrations and commissioning will be discussed, and the latest results will be presented.

  2. Heterogeneous next-generation wireless network interference model-and its applications

    KAUST Repository

    Mahmood, Nurul Huda

    2014-04-01

    Next-generation wireless systems facilitating better utilisation of the scarce radio spectrum have emerged as a response to inefficient and rigid spectrum assignment policies. These are comprised of intelligent radio nodes that opportunistically operate in the radio spectrum of existing primary systems, yet unwanted interference at the primary receivers is unavoidable. In order to design efficient next-generation systems and to minimise the adverse effect of their interference, it is necessary to realise how the resulting interference impacts the performance of the primary systems. In this work, a generalised framework for the interference analysis of such a next-generation system is presented where the nextgeneration transmitters may transmit randomly with different transmit powers. The analysis is built around a model developed for the statistical representation of the interference at the primary receivers, which is then used to evaluate various performance measures of the primary system. Applications of the derived interference model in designing the next-generation network system parameters are also demonstrated. Such approach provides a unified and generalised framework, the use of which allows a wide range of performance metrics can be evaluated. Findings of the analytical performance analyses are confirmed through extensive computer-based Monte-Carlo simulations. © 2012 John Wiley & Sons, Ltd.

  3. Quality of Service for Real-Time Applications Over Next Generation Data Networks

    Science.gov (United States)

    Atiquzzaman, Mohammed; Jain, Raj

    2001-01-01

    This project, which started on January 1, 2000, was funded by the NASA Glenn Research Center for duration of one year. The deliverables of the project included the following tasks: (1) Study of QoS mapping between the edge and core networks envisioned in the Next Generation networks will provide us with the QoS guarantees that can be obtained from next generation networks; (2) Buffer management techniques to provide strict guarantees to real-time end-to-end applications through preferential treatment to packets belonging to real-time applications. In particular, use of ECN to help reduce the loss on high bandwidth-delay product satellite networks needs to be studied; (3) Effect of Prioritized Packet Discard to increase goodput of the network and reduce the buffering requirements in the ATM switches; (4) Provision of new IP circuit emulation services over Satellite IP backbones using MPLS will be studied; and (5) Determine the architecture and requirements for internetworking ATN and the Next Generation Internet for real-time applications. The project has been completed on time. All the objectives and deliverables of the project have been completed. Research results obtained from this project have been published in a number of papers in journals, conferences, and technical reports, included in this document.

  4. The Development of the Advanced Light Water Reactor in Korea - The Korean Next Generation Reactor -

    Energy Technology Data Exchange (ETDEWEB)

    Kim, H.G.; Park, Y.S.; Kim, B.S.; Cho, S.J. [Korea Electric Power Research Institute, Taejon (Korea)

    1999-07-01

    Korean next generation reactor (KNGR), which is to be designed as a standard evolutionary advanced light water reactor (ALWR) in Korea, has been developed from 1992 as one of long-term government projects. The major characteristics of the KNGR are as follows; KNGR is 2-loop PWR and its design lift time is 60 years. The CDF and the CFF will be much lower than 10{sup -5}/RY and 10{sup -6}/RY, respectively. For the design improvement, KNGR adopted inconel-690 as a steam generator tube material, four train ECCS, refueling water storage tank inside containment, and double cylindrical concrete containment. For more reliable and easier control, compact workstations have been adopted in the design of main control complex and digital I and C technology is used for protection, control, and monitoring. In addition, KNGR has some passive design features such as fluidic device in safety injection tank, passive secondary condensing system, and passive auto-catalytic hydrogen recombiner to enhance safety. (author). 4 refs., 4 figs.

  5. Illuminating Solar Decathlon Homes: Exploring Next Generation Lighting Technology - Light Emitting Diodes

    Energy Technology Data Exchange (ETDEWEB)

    Gordon, Kelly L.; Gilbride, Theresa L.

    2008-05-22

    This report was prepared by PNNL for the US Department of Energy Building Technologies Program, Solid-State Lighting Program. The report will be provided to teams of university students who are building houses for the 2009 Solar Decathlon, a home design competition sponsored in part by DOE, to encourage teams to build totally solar powered homes. One aspect of the competition is lighting. This report provides the teams with information about LED lighting that can help them determine how they incorporate LED lighting into their homes. The report provides an overview of LED technology, a status of where LED technology is today, questions and answers about lighting quality, efficiency, lifetime etc.; numerous examples of LED products; and several weblinks for further research.

  6. Cycle layout studies of S-CO2 cycle for the next generation nuclear system application

    International Nuclear Information System (INIS)

    Ahn, Yoonhan; Bae, Seong Jun; Kim, Minseok; Cho, Seong Kuk; Baik, Seungjoon; Lee, Jeong Ik; Cha, Jae Eun

    2014-01-01

    According to the second law of thermodynamics, the next generation nuclear reactor system efficiency can potentially be increased with higher operating temperature. Fig.1 shows several power conversion system efficiencies and heat sources with respect to the system top operating temperature. As shown in Fig.1, the steam Rankine and gas Brayton cycles have been considered as the major power conversion systems more than several decades. In the next generation reactor operating temperature region (450 - 900 .deg. C), the steam Rankine and gas Brayton cycles have limits due to material problems and low efficiency, respectively. Among the future power conversion systems, S-CO 2 cycle is receiving interests due to several benefits including high efficiency under the mild turbine inlet temperature range (450-650 .deg. C), compact turbomachinery and simple layout compared to the steam Rankine cycle. S-CO 2 cycle can show relatively high efficiency under the mild turbine inlet temperature range (450-600 .deg. C) compared to other power conversion systems. The recompression cycle shows the best efficiency among other layouts and it is suitable for the application to advanced nuclear reactor systems. As S-CO 2 cycle performance can vary depending on the layout configuration, further studies on the layouts are required to design a better performing cycle

  7. The Semantic Web: opportunities and challenges for next-generation Web applications

    Directory of Open Access Journals (Sweden)

    2002-01-01

    Full Text Available Recently there has been a growing interest in the investigation and development of the next generation web - the Semantic Web. While most of the current forms of web content are designed to be presented to humans, but are barely understandable by computers, the content of the Semantic Web is structured in a semantic way so that it is meaningful to computers as well as to humans. In this paper, we report a survey of recent research on the Semantic Web. In particular, we present the opportunities that this revolution will bring to us: web-services, agent-based distributed computing, semantics-based web search engines, and semantics-based digital libraries. We also discuss the technical and cultural challenges of realizing the Semantic Web: the development of ontologies, formal semantics of Semantic Web languages, and trust and proof models. We hope that this will shed some light on the direction of future work on this field.

  8. Next-generation science information network for leading-edge applications

    Energy Technology Data Exchange (ETDEWEB)

    Urushidani, S. [National Institute of Informatics, 2-1-2 Hitotsubashi Chiyoda-ku, Tokyo 101-8430 (Japan)], E-mail: urushi@nii.ac.jp; Matsukata, J. [National Institute of Informatics, 2-1-2 Hitotsubashi Chiyoda-ku, Tokyo 101-8430 (Japan)

    2008-04-15

    High-speed networks are definitely essential tools for leading-edge applications in many research areas, including nuclear fusion research. This paper describes a number of advanced features in the Japanese next-generation science information network, called SINET3, and gives researchers clues on the uses of advanced high-speed network for their applications. The network services have four categories, multiple layer transfer, enriched virtual private network, enhanced quality-of-service, and bandwidth on demand services, and comprise a versatile service platform. The paper also describes the network architecture and advanced networking capabilities that enable economical service accommodation and flexible network resource assignment as well as effective use of Japan's first 40-Gbps lines.

  9. Cracking the Code of Human Diseases Using Next-Generation Sequencing: Applications, Challenges, and Perspectives.

    Science.gov (United States)

    Precone, Vincenza; Del Monaco, Valentina; Esposito, Maria Valeria; De Palma, Fatima Domenica Elisa; Ruocco, Anna; Salvatore, Francesco; D'Argenio, Valeria

    2015-01-01

    Next-generation sequencing (NGS) technologies have greatly impacted on every field of molecular research mainly because they reduce costs and increase throughput of DNA sequencing. These features, together with the technology's flexibility, have opened the way to a variety of applications including the study of the molecular basis of human diseases. Several analytical approaches have been developed to selectively enrich regions of interest from the whole genome in order to identify germinal and/or somatic sequence variants and to study DNA methylation. These approaches are now widely used in research, and they are already being used in routine molecular diagnostics. However, some issues are still controversial, namely, standardization of methods, data analysis and storage, and ethical aspects. Besides providing an overview of the NGS-based approaches most frequently used to study the molecular basis of human diseases at DNA level, we discuss the principal challenges and applications of NGS in the field of human genomics.

  10. Next-generation science information network for leading-edge applications

    International Nuclear Information System (INIS)

    Urushidani, S.; Matsukata, J.

    2008-01-01

    High-speed networks are definitely essential tools for leading-edge applications in many research areas, including nuclear fusion research. This paper describes a number of advanced features in the Japanese next-generation science information network, called SINET3, and gives researchers clues on the uses of advanced high-speed network for their applications. The network services have four categories, multiple layer transfer, enriched virtual private network, enhanced quality-of-service, and bandwidth on demand services, and comprise a versatile service platform. The paper also describes the network architecture and advanced networking capabilities that enable economical service accommodation and flexible network resource assignment as well as effective use of Japan's first 40-Gbps lines

  11. Cracking the Code of Human Diseases Using Next-Generation Sequencing: Applications, Challenges, and Perspectives

    Directory of Open Access Journals (Sweden)

    Vincenza Precone

    2015-01-01

    Full Text Available Next-generation sequencing (NGS technologies have greatly impacted on every field of molecular research mainly because they reduce costs and increase throughput of DNA sequencing. These features, together with the technology’s flexibility, have opened the way to a variety of applications including the study of the molecular basis of human diseases. Several analytical approaches have been developed to selectively enrich regions of interest from the whole genome in order to identify germinal and/or somatic sequence variants and to study DNA methylation. These approaches are now widely used in research, and they are already being used in routine molecular diagnostics. However, some issues are still controversial, namely, standardization of methods, data analysis and storage, and ethical aspects. Besides providing an overview of the NGS-based approaches most frequently used to study the molecular basis of human diseases at DNA level, we discuss the principal challenges and applications of NGS in the field of human genomics.

  12. Scalable Multicasting over Next-Generation Internet Design, Analysis and Applications

    CERN Document Server

    Tian, Xiaohua

    2013-01-01

    Next-generation Internet providers face high expectations, as contemporary users worldwide expect high-quality multimedia functionality in a landscape of ever-expanding network applications. This volume explores the critical research issue of turning today’s greatly enhanced hardware capacity to good use in designing a scalable multicast  protocol for supporting large-scale multimedia services. Linking new hardware to improved performance in the Internet’s next incarnation is a research hot-spot in the computer communications field.   The methodical presentation deals with the key questions in turn: from the mechanics of multicast protocols to current state-of-the-art designs, and from methods of theoretical analysis of these protocols to applying them in the ns2 network simulator, known for being hard to extend. The authors’ years of research in the field inform this thorough treatment, which covers details such as applying AOM (application-oriented multicast) protocol to IPTV provision and resolving...

  13. The virtuous technology cycle concept and its application in next-generation sequencing.

    Science.gov (United States)

    Pluess-Li, Ying; Bongiovanni, Sandrine; Oakeley, Edward J; Johnson, Keith J; Staedtler, Frank

    2012-09-01

    External access to scientific technology plays an increasingly important part in pharmaceutical R&D. One advantage of accessing technology externally is the avoidance of costs associated with purchase and the reduced time required for developing new methods; in addition, access to external scientific expertise can be beneficial. However, few conceptual frameworks exist for achieving an optimal mix of internal and external technology access. In this review, we describe the virtuous technology cycle (VTC) concept and exemplify its application to next-generation sequencing (NGS). Based on selected examples, we show that the VTC concept can greatly enhance the number of technologies accessed and thus significantly increase flexibility and efficiency in drug discovery. We also discuss the challenges of externally accessing NGS technologies. Copyright © 2012 Elsevier Ltd. All rights reserved.

  14. Applications and Security of Next-Generation, User-Centric Wireless Systems

    Directory of Open Access Journals (Sweden)

    Danfeng Yao

    2010-07-01

    Full Text Available Pervasive wireless systems have significantly improved end-users’ quality of life. As manufacturing costs decrease, communications bandwidth increases, and contextual information is made more readily available, the role of next generation wireless systems in facilitating users’ daily activities will grow. Unique security and privacy issues exist in these wireless, context-aware, often decentralized systems. For example, the pervasive nature of such systems allows adversaries to launch stealthy attacks against them. In this review paper, we survey several emergent personal wireless systems and their applications. These systems include mobile social networks, active implantable medical devices, and consumer products. We explore each system’s usage of contextual information and provide insight into its security vulnerabilities. Where possible, we describe existing solutions for defendingagainst these vulnerabilities. Finally, we point out promising future research directions for improving these systems’ robustness and security

  15. [Application of next-generation semiconductor sequencing technologies in genetic diagnosis of inherited cardiomyopathies].

    Science.gov (United States)

    Zhao, Yue; Zhang, Hong; Xia, Xue-shan

    2015-07-01

    Inherited cardiomyopathy is the most common hereditary cardiac disease. It also causes a significant proportion of sudden cardiac deaths in young adults and athletes. So far, approximately one hundred genes have been reported to be involved in cardiomyopathies through different mechanisms. Therefore, the identification of the genetic basis and disease mechanisms of cardiomyopathies are important for establishing a clinical diagnosis and genetic testing. Next-generation semiconductor sequencing (NGSS) technology platform is a high-throughput sequencer capable of analyzing clinically derived genomes with high productivity, sensitivity and specificity. It was launched in 2010 by Life Technologies of USA, and it is based on a high density semiconductor chip, which was covered with tens of thousands of wells. NGSS has been successfully used in candidate gene mutation screening to identify hereditary disease. In this review, we summarize these genetic variations, challenge and application of NGSS in inherited cardiomyopathy, and its value in disease diagnosis, prevention and treatment.

  16. Standardization of DNA extraction from sand flies: Application to genotyping by next generation sequencing.

    Science.gov (United States)

    Casaril, Aline Etelvina; de Oliveira, Liliane Prado; Alonso, Diego Peres; de Oliveira, Everton Falcão; Gomes Barrios, Suellem Petilim; de Oliveira Moura Infran, Jucelei; Fernandes, Wagner de Souza; Oshiro, Elisa Teruya; Ferreira, Alda Maria Teixeira; Ribolla, Paulo Eduardo Martins; de Oliveira, Alessandra Gutierrez

    2017-06-01

    Standardization of the methods for extraction of DNA from sand flies is essential for obtaining high efficiency during subsequent molecular analyses, such as the new sequencing methods. Information obtained using these methods may contribute substantially to taxonomic, evolutionary, and eco-epidemiological studies. The aim of the present study was to standardize and compare two methods for the extraction of genomic DNA from sand flies for obtaining DNA in sufficient quantities for next-generation sequencing. Sand flies were collected from the municipalities of Campo Grande, Camapuã, Corumbá and Miranda, state of Mato Grosso do Sul, Brazil. Three protocols using a silica column-based commercial kit (ReliaPrep™ Blood gDNA Miniprep System kit, Promega ® ), and three protocols based on the classical phenol-chloroform extraction method (Uliana et al., 1991), were compared with respect to the yield and quality of the extracted DNA. DNA was quantified using a Qubit 2.0 fluorometer. The presence of sand fly DNA was confirmed by PCR amplification of the IVS6 region (constitutive gene), followed by electrophoresis on a 1.5% agarose gel. A total of 144 male specimens were analyzed, 72 per method. Significant differences were observed between the two methods tested. Protocols 2 and 3 of phenol-chloroform extraction presented significantly better performance than all commercial kit extraction protocols tested. For phenol-chloroform extraction, protocol 3 presented significantly better performance than protocols 1 and 2. The IVS6 region was detected in 70 of 72 (97.22%) samples extracted with phenol, including all samples for protocols 2 and 3. This is the first study on the standardization of methods for the extraction of DNA from sand flies for application to next-generation sequencing, which is a promising tool for entomological and molecular studies of sand flies. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Innovative Development of Next Generation and Energy Efficient Solid State Light Sources for General Illumination

    Energy Technology Data Exchange (ETDEWEB)

    Ian Ferguson

    2006-07-31

    This two year program resulted in a novel broadband spectrally dynamic solid state illumination source (BSDLED) that uses a dual wavelength light emitting diode (LED) and combinations of phosphors to create a broadband emission that is real-time controllable. Four major focuses of this work were as follows: (1) creation of a two terminal dual wavelength LED with control of the relative intensities of the two emission peaks, (2) bandgap modeling of the two terminal dual LED to explain operation based on the doping profile, (3) novel use of phosphor combinations with dual LEDs to create a broadband spectral power distribution that can be varied to mimic a blackbody radiator over a certain range and (4) investigation of novel doping schemes to create tunnel junctions or equivalent buried current spreading layers in the III-nitrides. Advances were achieved in each of these four areas which could lead to more efficient solid state light sources with greater functionality over existing devices. The two-terminal BSDLED is an important innovation for the solid-state lighting industry as a variable spectrum source. A three-terminal dual emitter was also investigated and appears to be the most viable approach for future spectrally dynamic solid state lighting sources. However, at this time reabsorption of emission between the two active regions limits the usefulness of this device for illumination applications.

  18. The Role of Next-Generation Sequencing in Sarcomas: Evolution From Light Microscope to Molecular Microscope.

    Science.gov (United States)

    Groisberg, Roman; Roszik, Jason; Conley, Anthony; Patel, Shreyaskumar R; Subbiah, Vivek

    2017-10-13

    Sarcomas are rare, heterogeneous group of soft tissue and bone tumors. Precise diagnosis of specific subtypes is challenging using conventional methods. Herein, we review the role of next-generation sequencing (NGS) technology that is used for rapid sequencing of DNA and RNA. Recent sarcoma specific studies recommend that molecular genetic testing should be added at diagnosis for appropriate clinical management in addition to diagnosis by expert pathologists. NGS has already been used to identify potentially actionable mutations, copy number alterations, and gene fusions. Rationally, choosing a drug based on an individual patient profile aka: "precision oncology" has been so far limited to few case reports in sarcomas. As we improve our ability to deliver personalized medicine using all modalities including conventional therapy, more patients may eventually benefit. As the cost and capacity of NGS outpace Moore's law, so does the probability of success.

  19. Next Generation Car — Example of Function Integration at the Light Urban Vehicle (LUV) Vehicle Concept

    Science.gov (United States)

    Kopp, G.; Brückmann, S.; Kriescher, M.; Friedrich, H. E.

    In times of climate change vehicle emissions have to be reduced clearly. One possibility is to reduce the mass of the body in white using lightweight sandwich structures. The department `Lightweight and Hybrid Design Methods' of the Institute of Vehicle Concepts develops a vehicle body structure by using sandwiches with aluminum top layers and polyurethane foam as core material. For that the foam and the sandwiches were investigated under different load cases, e.g. pressure loading and in-plane tests. In tests with components the high potential of the sandwich materials were shown. On the dynamic component test facility of the institute, vehicle front structures were tested successfully. The results of all investigations regarding sandwich materials, integration of functions (e.g. crash, thermal) in vehicle structures and the concept LUV are developed under the research program of Next Generation Car of the DLR. We will show the development and results of the LUV.

  20. CANEapp: a user-friendly application for automated next generation transcriptomic data analysis.

    Science.gov (United States)

    Velmeshev, Dmitry; Lally, Patrick; Magistri, Marco; Faghihi, Mohammad Ali

    2016-01-13

    Next generation sequencing (NGS) technologies are indispensable for molecular biology research, but data analysis represents the bottleneck in their application. Users need to be familiar with computer terminal commands, the Linux environment, and various software tools and scripts. Analysis workflows have to be optimized and experimentally validated to extract biologically meaningful data. Moreover, as larger datasets are being generated, their analysis requires use of high-performance servers. To address these needs, we developed CANEapp (application for Comprehensive automated Analysis of Next-generation sequencing Experiments), a unique suite that combines a Graphical User Interface (GUI) and an automated server-side analysis pipeline that is platform-independent, making it suitable for any server architecture. The GUI runs on a PC or Mac and seamlessly connects to the server to provide full GUI control of RNA-sequencing (RNA-seq) project analysis. The server-side analysis pipeline contains a framework that is implemented on a Linux server through completely automated installation of software components and reference files. Analysis with CANEapp is also fully automated and performs differential gene expression analysis and novel noncoding RNA discovery through alternative workflows (Cuffdiff and R packages edgeR and DESeq2). We compared CANEapp to other similar tools, and it significantly improves on previous developments. We experimentally validated CANEapp's performance by applying it to data derived from different experimental paradigms and confirming the results with quantitative real-time PCR (qRT-PCR). CANEapp adapts to any server architecture by effectively using available resources and thus handles large amounts of data efficiently. CANEapp performance has been experimentally validated on various biological datasets. CANEapp is available free of charge at http://psychiatry.med.miami.edu/research/laboratory-of-translational-rna-genomics/CANE-app . We

  1. Applications and challenges of next-generation sequencing in Brassica species.

    Science.gov (United States)

    Wei, Lijuan; Xiao, Meili; Hayward, Alice; Fu, Donghui

    2013-12-01

    Next-generation sequencing (NGS) produces numerous (often millions) short DNA sequence reads, typically varying between 25 and 400 bp in length, at a relatively low cost and in a short time. This revolutionary technology is being increasingly applied in whole-genome, transcriptome, epigenome and small RNA sequencing, molecular marker and gene discovery, comparative and evolutionary genomics, and association studies. The Brassica genus comprises some of the most agro-economically important crops, providing abundant vegetables, condiments, fodder, oil and medicinal products. Many Brassica species have undergone the process of polyploidization, which makes their genomes exceptionally complex and can create difficulties in genomics research. NGS injects new vigor into Brassica research, yet also faces specific challenges in the analysis of complex crop genomes and traits. In this article, we review the advantages and limitations of different NGS technologies and their applications and challenges, using Brassica as an advanced model system for agronomically important, polyploid crops. Specifically, we focus on the use of NGS for genome resequencing, transcriptome sequencing, development of single-nucleotide polymorphism markers, and identification of novel microRNAs and their targets. We present trends and advances in NGS technology in relation to Brassica crop improvement, with wide application for sophisticated genomics research into agronomically important polyploid crops.

  2. The application of next-generation sequencing techniques in studying transcriptional regulation in embryonic stem cells.

    Science.gov (United States)

    Liu, Ya-Jun; Zhang, Feng; Liu, Hong-de; Sun, Xiao

    2017-08-20

    The mechanism of transcriptional regulation has been the focus of many studies in the post-genomic era. The development of sequencing-based technologies for chromatin profiling enables current researchers to experimentally measure chromatin properties. Moreover, many studies aim at annotating the state of the chromatin into broad categories based on observed chromatin features and/or DNA sequences, then associating the resultant distal regulatory regions with the correct target genes based on DNA sequences, and predicting the dependence of epigenetic features on genetic variation. Stem cell biology has many applications in the area of regenerative medicine and tumorigenesis. In this review, we summarize recent research progresses on the application of next-generation sequencing techniques in studying transcriptional regulation in embryonic stem cells. This review mainly focuses on four areas: (1) microarray or RNA-seq; (2) chromatin immunoprecipitation (ChIP); (3) Dnase I hypersensitive sites (DHSs); (4) high-throughput chromosome conformation capture (Hi-C). These technologies have been utilized in studying chromatin on three levels, i.e., gene expression, transcription factor binding and genome three-dimensional structure. We especially emphasize three master transcription factors of pluripotency: Oct4, Sox2 and Nanog. We aim to track the frontier of stem cell transcriptional regulation research and share important progresses in this field.

  3. Application of Neutron Measurements to Advance Semiconductor Manufacturing: Next-Generation Lithography and Nanoporous Thin Films

    Science.gov (United States)

    Lin, Eric

    2010-03-01

    As feature sizes in microelectronic devices continue to decrease to sub-32 nm dimensions, new measurement methods are needed to understand the physical phenomena used in state-of-the-art lithography methods that may limit their fabrication and probe the structure and properties of new electronics materials. Neutron (and x-ray) beams have emerged as powerful probes of new manufactured structures with characteristic length scales ranging from (1 to 100) nm in thin films and in the bulk. In particular, X-ray reflectivity (XR), neutron reflectivity (NR), small angle neutron scattering (SANS), and small angle X-ray scattering (SAXS) can be applied in novel ways to address fundamental issues important to the microelectronics industry. This talk with highlight the application of neutron and x-ray measurement methods to investigate important problems in the development of photoresist materials used in lithography and of nanoporous low-dielectric-constant materials needed for next generation integrated circuits. Specific topics include: 1) the direct measurement of the reaction-diffusion front with nanometer resolution from ideal line-edges to probe image blur and roughness from photoacid diffusion 2) identification and measurement of a ``residual swelling fraction'' during the development and 3) measurements of the pore structure of low-dielectric constant thin films. Insights from these studies can provide guidelines and opportunities for the further extension of photoresist technology into the future and the integration of new materials into integrated circuits.

  4. Demonstration of a high speed hybrid electrical and optical sensing system for next generation launcher applications

    Science.gov (United States)

    Ibrahim, Selwan K.; O'Dowd, John A.; Honniball, Arthur; Bessler, Vivian; Farnan, Martin; O'Connor, Peter; Melicher, Milos; Gleeson, Danny

    2017-09-01

    The Future Launchers Preparatory Programme (FLPP) supported by the European Space Agency (ESA) has a goal of developing various launch vehicle system concepts and identifying the technologies required for the design of Europe's Next-Generation Launcher (NGL) while maintaining competitiveness on the commercial market. Avionics fiber optic sensing technology was investigated as part of the FLPP programme. Here we demonstrate and evaluate a high speed hybrid electrical/optical data acquisition system based on commercial off the shelf (COTS) technology capable of acquiring data from traditional electrical sensors and optical Fibre Bragg Grating (FBG) sensors. The proposed system consists of the KAM-500 data acquisition system developed by Curtis-Wright and the I4 tunable laser based fiber optic sensor interrogator developed by FAZ Technology. The key objective was to demonstrate the capability of the hybrid system to acquire data from traditional electrical sensors used in launcher applications e.g. strain, temperature and pressure in combination with optical FBG sensors, as well as data delivery to spacecraft avionics systems. The KAM-500 was configured as the main acquisition unit (MAU) and provided a 1 kHz sampling clock to the I4 interrogator that was configured as the secondary acquisition unit (SAU) to synchronize the data acquisition sample rate between both systems. The SAU acquired data from an array of optical FBG sensors, while the MAU data acquisition system acquired data from the electrical sensors. Data acquired from the optical sensors was processed by the FAZ I4 interrogation system and then encapsulated into UDP/IP packets and transferred to the KAM-500. The KAM-500 encapsulated the optical sensor data together with the data acquired from electrical sensors and transmitted the data over MIL-STD-1553 and Ethernet data interface. The temperature measurements resulted in the optical and electrical sensors performing on a par with each other, with all

  5. Potential application of LIBS to NNSA next generation safeguards initiative (NGSI)

    Energy Technology Data Exchange (ETDEWEB)

    Barefield Ii, James E [Los Alamos National Laboratory; Clegg, Samuel M [Los Alamos National Laboratory; Veirs, Douglas K [Los Alamos National Laboratory; Browne, Mike [Los Alamos National Laboratory; Lopez, Leon [Los Alamos National Laboratory; Martinez, Ron [Los Alamos National Laboratory; Le, Loan [Los Alamos National Laboratory; Lamontagne, Stephen A [DOE/NNSA/NA241; Veal, Kevin [NN/ADTR

    2009-01-01

    In a climate in which states and nations have been and perhaps currently are involved in the prol iferation of nuclear materials and technologies, advanced methodologies and improvements in current measurement techniques are needed to combat new threats and increased levels of sophistication. The Department of Energy through the National Nuclear Security Administration (NNSA) has undertaken a broad review of International Safeguards. The conclusion from that review was that a comprehensive initiative to revitalize international safeguards technology and the human resource base was urgently needed to keep pace with demands and increasingly sophisticated emerging safeguards challenges. To address these challenges, NNSA launched the Next Generation Safeguards Initiative (NGSI) to develop policies, concepts, technologies, expertise, and infrastructure necessary to sustain the international safeguards system as its mission evolves for the next 25 years. NGSI is designed to revitalize and strengthen the U.S. safeguards technical base, recognizing that without a robust program the United States of America will not be in a position to exercise leadership or provide the necessary support to the IAEA (International Atomic Energy Agency). International safeguards as administrated by the IAEA are the primary vehicle for verifying compliance with the peaceful use and nonproliferation of nuclear materials and technologies. Laser Induced Breakdown Spectroscopy or LIBS has the potential to support the goals of NGSI as follows: by providing (1) automated analysis in complex nuclear processing or reprocessing facilities in real-time or near real-time without sample preparation or removal, (2) isotopic and important elemental ratio (Cm/Pu, Cm/U, ... etc) analysis, and (3) centralized remote control, process monitoring, and analysis of nuclear materials in nuclear facilities at multiple locations within the facility. Potential application of LIBS to international safeguards as

  6. Application of next generation sequencing in clinical microbiology and infection prevention

    NARCIS (Netherlands)

    Deurenberg, Ruud H.; Bathoorn, Erik; Chlebowicz, Monika A.; Couto, Natacha; Ferdous, Mithila; Garcia-Cobos, Silvia; Kooistra-Smid, Anna M. D.; Raangs, Erwin C.; Rosema, Sigrid; Veloo, Alida C. M.; Zhou, Kai; Friedrich, Alexander W.; Rossen, John W. A.

    2017-01-01

    Current molecular diagnostics of human pathogens provide limited information that is often not sufficient for outbreak and transmission investigation. Next generation sequencing (NGS) determines the DNA sequence of a complete bacterial genome in a single sequence run, and from these data,

  7. Reprint of "Application of next generation sequencing in clinical microbiology and infection prevention"

    NARCIS (Netherlands)

    Deurenberg, Ruud H.; Bathoorn, Erik; Chlebowicz, Monika A.; Monge Gomes do Couto, Natacha; Ferdous, Mithila; Garcia-Cobos, Silvia; Kooistra-Smid, Anna M. D.; Raangs, Erwin C.; Rosema, Sigrid; Veloo, Alida C. M.; Zhou, Kai; Friedrich, Alexander W.; Rossen, John W. A.

    2017-01-01

    Current molecular diagnostics of human pathogens provide limited information that is often not sufficient for outbreak and transmission investigation. Next generation sequencing (NGS) determines the DNA sequence of a complete bacterial genome in a single sequence run, and from these data,

  8. Dynalight Next Generation

    DEFF Research Database (Denmark)

    Jørgensen, Bo Nørregaard; Ottosen, Carl-Otto; Dam-Hansen, Carsten

    2016-01-01

    The project aims to develop the next generation of energy cost-efficient artificial lighting control that enables greenhouse growers to adapt their use of artificial lighting dynamically to fluctuations in the price of electricity. This is a necessity as fluctuations in the price of electricity can...... be so large that it directly affects the production costs. The project results show that the newly developed lighting control software, DynaLight NG, allows greenhouse growers to adapt their use of artificial lighting to market variations in electricity prices without negative impacts on plant quality...... or production time. The electricity savings that DynaLight NG can achieve depends on the installed lamp type. When used together with conventional SON-T lamps DynaLight NG can achieve an electricity savings of 25% compared to traditional artificial lighting control. The project results also show that shifting...

  9. High Brightness Electron Guns for Next-Generation Light Sources and Accelerators

    International Nuclear Information System (INIS)

    H. Bluem; M.D. Cole; J. Rathke; T. Schultheiss; A.M.M. Todd; I. Ben-Zvi; T. Srinivasan-Rao; P. Colestock; D.C. Nguyen; R.L. Wood; L. Young; D. Janssen; J. Lewellen; G. Neil; H.L. Phillips; J.P. Preble

    2004-01-01

    Advanced Energy Systems continues to develop advanced electron gun and injector concepts. Several of these projects have been previously described, but the progress and status of each will be updated. The project closest to completion is an all superconducting RF (SRF) gun, being developed in collaboration with the Brookhaven National Laboratory, that uses the niobium of the cavity wall itself as the photocathode material. This gun has been fabricated and will shortly be tested with beam. The cavity string for a closely-coupled DC gun and SRF cavity injector that is expected to provide beam quality sufficient for proposed ERL light sources and FELs will be assembled at the Jefferson Laboratory later this year. We are also collaboration with Los Alamos on a prototype CW normal-conducting RF gun with similar performance, that will undergo thermal testing in late 2004. Another CW SRF gun project that uses a high quantum efficiency photocathode, similar to the FZ-Rossendorf approach, has just begun. Finally, we will present the RF design and cold test results for a fully axisymmetric, ultra-high-brightness x-band RF gun

  10. Next generation light robotic

    DEFF Research Database (Denmark)

    Villangca, Mark Jayson; Palima, Darwin; Banas, Andrew Rafael

    2017-01-01

    Conventional robotics provides machines and robots that can replace and surpass human performance in repetitive, difficult, and even dangerous tasks at industrial assembly lines, hazardous environments, or even at remote planets. A new class of robotic systems no longer aims to replace humans...

  11. Beyond the Lambertian limit: Novel low-symmetry gratings for ultimate light trapping enhancement in next-generation photovoltaics

    Energy Technology Data Exchange (ETDEWEB)

    Birkmire, Robert [Univ. of Delaware, Newark, DE (United States); Hu, Juejun [Univ. of Delaware, Newark, DE (United States); Richardson, Kathleen [Univ. of Central Florida, Orlando, FL (United States). College of Optics and Photonics, Center for Research and Education in Optics and Lasers (CREOL)

    2016-05-20

    This project aims at addressing the efficiency limit and high fabrication cost of current light trapping methods by developing novel low-symmetry gratings (LSG) for next-generation thin c-Si photovoltaic (PV) cells. The LSG design achieves light trapping enhancement exceeding the 4n2 Lambertian limit and can be fabricated over large areas using low-cost, single-step nanoimprint techniques. We further explored the use of deposited high-refractive-index glass materials for low-temperature LSG processing, which enables direct imprint sculpting of even complex grating geometries in glass without requiring an additional pattern transfer step, which minimizes processing cost and surface damage to PV cells. In the project, we have demonstrated fabrication and integration of sub-wavelength LSG with thin c-Si wafers and bifacial solar cells with low defect density. Optical absorption measurements indicate that LSGs demonstrated superior absorption enhancement compared to their traditional symmetric counterparts as predicted by our simulations. Efficiency enhancement was observed in solar cells integrated with LSGs although fabrication yield of the LSG-integrated cells remains a challenge

  12. Beyond Graphene: Advanced 2D Electronic and Optoelectronic Crystals and Devices for Next Generation Applications

    Science.gov (United States)

    2015-06-25

    applications, including field effect transistors , photodetectors, chemical and biological sensors, and nano- electromechanical systems. However, there are...plasmons in light excitation. They also pointed out using multilayers up to 300nm could lead to better contact for MoS2 field - effect transistors (FET...bandstructure symmetry for tunneling Field -Effiect transistors (TFET). Stacking of 2D materials can be sued for interlayer TFETs and SymFETs with

  13. Hacking the next generation

    CERN Document Server

    Dhanjani, Nitesh; Hardin, Brett

    2009-01-01

    With the advent of rich Internet applications, the explosion of social media, and the increased use of powerful cloud computing infrastructures, a new generation of attackers has added cunning new techniques to its arsenal. For anyone involved in defending an application or a network of systems, Hacking: The Next Generation is one of the few books to identify a variety of emerging attack vectors. You'll not only find valuable information on new hacks that attempt to exploit technical flaws, you'll also learn how attackers take advantage of individuals via social networking sites, and abuse

  14. The Application of Next Generation Sequencing Technology on Noninvasive Prenatal Test

    DEFF Research Database (Denmark)

    Jiang, Hui

    a sensitivity and specificity of over 99%, which can provide accurate and reliable results and thus avoid most of invasive process compared to standard prenatal test. Moreover,we also designed probes for genes related to Monogenetic disorders and conducted target region sequencing for parents, proband......There are nearly 7000 rare diseases that have been reported in the world. Although most of them occur with a frequency of less than one in 2000, in total about 6% of the population suffers from rare diseases. These rare diseases are often caused by changes in genes, which is currently lack...... of effective treatment. The rapid development of next generation sequencing technology boosts the discovery of new causative gene for these rare diseases, as well as the genetic diagnosis in clinic practice. Carrier screening, prenatal diagnosis and newborn screening are wildly used in the world to prevent...

  15. Application of Next Generation Sequencing in Mammalian Embryogenomics: Lessons Learned from Endogenous Betaretroviruses of Sheep

    Science.gov (United States)

    Spencer, Thomas E.; Palmarini, Massimo

    2012-01-01

    Endogenous retroviruses (ERVs) are present in the genome of all vertebrates and are remnants of ancient exogenous retroviral infections of the host germline transmitted vertically from generation to generation. The sheep genome contains 27 JSRV-related endogenous betaretroviruses (enJSRVs) related to the pathogenic Jaagsiekte sheep retrovirus (JSRV) that have been integrating in the host genome for the last 5 to 7 million years. The exogenous JSRV is a causative agent of a transmissible lung cancer in sheep, and enJSRVs are able to protect the host against JSRV infection. In sheep, the enJSRVs are most abundantly expressed in the uterine epithelia as well as in the conceptus (embryo and associated extraembryonic membranes) trophectoderm. Sixteen of the 27 enJSRV loci contain an envelope (env) gene with an intact open reading frame, and in utero loss-of-function experiments found the enJSRVs Env to be essential for trophoblast outgrowth and conceptus elongation. Collectively, available evidence supports the ideas that genes captured from ancestral retroviruses were pivotal in the acquisition of new, important functions in mammalian evolution and were positively selected for biological roles in genome plasticity, protection of the host against infection of related pathogenic and exogenous retroviruses, and a convergent physiological role in placental morphogenesis and thus mammalian reproduction. The discovery of ERVs in mammals was initially based on molecular cloning discovery techniques and will be boosted forward by next generation sequencing technologies and in silico discovery techniques. PMID:22951118

  16. [The new challenge in oncology: Next-generation sequencing and its application in precision medicine].

    Science.gov (United States)

    Calabria, Inés; Pedrola, Laia; Berlanga, Pablo; Aparisi, María José; Sánchez-Izquierdo, Dolors; Cañete, Adela; Cervera, José; Millán, José María; Castel, Victoria

    2016-11-01

    Precision Medicine is an emerging approach for the diagnosis, treatment and prognosis of genetic diseases that enables clinicians to more accurately predict which treatment strategy will be optimal in a patient. The aim of Precision Medicine in Oncology is to integrate clinical, histological, and molecular data in order to obtain a deeper knowledge about the biology and genetics of an individual's tumour. Over the last few years, the implementation of new NGS (Next Generation Sequencing) technologies into clinical practice has been essential. There is a wide variety of NGS techniques that can be used in this context. The correct interpretation of molecular changes detected by these techniques is paramount for their appropriate use. In this review, a discussion is presented on the main NGS sequencing technologies that can be used to improve the diagnosis, prognosis, and treatment of oncology patients. Copyright © 2016 Asociación Española de Pediatría. Publicado por Elsevier España, S.L.U. All rights reserved.

  17. Design-by-analysis application to next generation BWR fuel thermal design method

    International Nuclear Information System (INIS)

    Yamamoto, Yasushi; Mitsutake, Toru

    2008-01-01

    For BWR core thermal design methods, the full mock-up thermal-hydraulic tests have been needed, such as the critical power measurement test, pressure drop measurement test and so on for more than thirty years since 1976. However, the full mock-up test required the high costs and large-scale test facility. Now, there are only a few test facilities in the world to perform the full mock-up thermal-hydraulic test. Moreover, for future BWR, the bundle size tends to be larger, because of reducing the plant construction costs and minimizing days taken for the periodic check. For instance, AB1600, improved ABWR, was proposed from Toshiba (Imaruoka et al., 2005), whose bundle size was 1.2 times larger than the conventional BWR fuel size. It is too expensive and far from realistic to perform the full mock-up thermal-hydraulic test for such a large size fuel bundle on every new bundle design. The new design procedure is exactly expected at reasonable costs and required to perform the large scale bundle design development, especially for the next generation BWR. Then, we propose a kind of Design by Analysis method combined with the alternative to the full mock-up tests. We called Practical Design-by-Analysis (PDBA) method even more effective and with better accuracy than Full Design-by-Analysis (FDBA). The PDBA method was applied successfully to produce the critical power correlation for the current 8x8 fuel. The estimation error was almost equal to that of the design correlation developed empirically with the full mock-up test data. (author)

  18. Organism-specific rRNA capture system for application in next-generation sequencing.

    Directory of Open Access Journals (Sweden)

    Sai-Kam Li

    Full Text Available RNA-sequencing is a powerful tool in studying RNomics. However, the highly abundance of ribosomal RNAs (rRNA and transfer RNA (tRNA have predominated in the sequencing reads, thereby hindering the study of lowly expressed genes. Therefore, rRNA depletion prior to sequencing is often performed in order to preserve the subtle alteration in gene expression especially those at relatively low expression levels. One of the commercially available methods is to use DNA or RNA probes to hybridize to the target RNAs. However, there is always a concern with the non-specific binding and unintended removal of messenger RNA (mRNA when the same set of probes is applied to different organisms. The degree of such unintended mRNA removal varies among organisms due to organism-specific genomic variation. We developed a computer-based method to design probes to deplete rRNA in an organism-specific manner. Based on the computation results, biotinylated-RNA-probes were produced by in vitro transcription and were used to perform rRNA depletion with subtractive hybridization. We demonstrated that the designed probes of 16S rRNAs and 23S rRNAs can efficiently remove rRNAs from Mycobacterium smegmatis. In comparison with a commercial subtractive hybridization-based rRNA removal kit, using organism-specific probes is better in preserving the RNA integrity and abundance. We believe the computer-based design approach can be used as a generic method in preparing RNA of any organisms for next-generation sequencing, particularly for the transcriptome analysis of microbes.

  19. [Application of Next Generation Sequencing for AML/MDS Diagnosis and Treatment].

    Science.gov (United States)

    Cheng, Huan-Chen; Liu, Sheng-Wei; Liu, Yu; Zhao, Xue-Fei; Li, Wei; Qiu, Lin; Ma, Jun

    2017-12-01

    To detect the mutations of AML/MDS- related genes by using next generation sequencing (NGS), to analyze the mutation levels of each genes in the AML/MDS and the sensitivity of NGS, and to evaluate the feasibility of gene mutations for monitoring the MRD and predicating the progression of diseases. The specimens were collected from primary AML (68 cases) and MDS (57 cases) patients from August 2015 to June 2016 in the Harbin Institute of Hematology and Oncology. The mutations of 22 related genes were detected by using AML/MDS-NGS chips. TET2 gene showed the highest mutation rate in AML (55.9%) and MDS (56.1%). The gene mutations were as follows: CEBPA (11.8%), DNMT3A (7.4%), C-KIT (7.4%) and FLT3-ITD (7.4%) in AML, and U2AF1 (10.5%) and SRSF2 (10.5%) in MDS. All the genes had specific mutation sites except TP53 and CEBPA. The mutations of FLT3, C-KIT and CEBPA became negative in the 5 AML patients in remission when compared with those at primary attack, but the mutation rate of TET2 gene was not obviously changed, whereas the mutation rate of the 5 MDS patients was not significantly changed. The new gene mutations appeared in 3 MDS patients with disease progression, but the mutation rate was not changed significantly in the disease progression. The gene mutation rate still has not been changed significantly even after remission. Both AML and MDS have their own specific mutated genes and sites. Some gene mutations, such as CEBPA, can be used as an effective indicator to monitoring MRD in AML patients, but those only used for the evaluation of the disease progression and prognosis in MDS patients.

  20. [Application of next-generation DNA sequencing for prenatal testing of fetal chromosomal aneuploidies].

    Science.gov (United States)

    Liu, Jing; Wang, Hua; Xi, Hui; Jia, Zhengjun; Zhou, Yuchun; Wu, Lingqian

    2015-08-01

    To explore the value of next-generation sequencing for the non-invasive prenatal testing of fetal chromosomal aneuploidies. Plasma from 4004 women with singleton pregnancy at a gestational age between 12-35(+5) weeks was collected prior to amniocentesis between April 19th 2011 and December 31st 2013. The samples were divided into three groups: (1) High risk for Down syndrome by biochemical screening; (2) Advanced maternal age; (3) Abnormalities by ultrasound or other methods. Plasma DNA extracted from above samples was sequenced at low coverage. Positive results were verified against the karyotypes of the fetuses. For those with negative results, the fetuses were followed up by telephone call for at least six months after birth. Among 4003 samples subjected to non-invasive prenatal diagnosis, 66 (1.65%) had a positive result. In group 1, 22 cases of trisomy 21 (T21), 3 cases of trisomy 18 (T18), 1 case of 13 trisomy (T13), 8 cases of 45,X and 2 cases of other chromosomal abnormality were detected. In group 2, 13 cases of T21, 2 cases of T18, 1 case of T13, 5 cases of 45,X, 2 cases of 47,XXN and 1 case of other chromosomal abnormality were detected. In group 3, 1 case of T21, 1 case of T18, 1 case of T13, and 3 cases of 47,XXN were detected. For 55 samples underwent prenatal diagnosis, 30 cases of T21 and 4 cases of T18 were discovered, which was consistent with the results of non-invasive prenatal diagnosis. For the 13 cases indicated as 45,X, 3 were verified by karyotype analysis, 2 were verified as mosaicism (45,X/46,XN), 8 were 46,XN (false positives). For the 5 cases indicated as 47,XXN, 2 were verified by karyotype analysis, the other 3 were 46,XN (false positives). Karyotypes of 3 cases suspected for other chromosomal abnormalities were all verified as 46,XN (false positive). Until May 1st 2014, telephone follow-up for those with negative screening results only identified a boy with facial abnormalities and developmental delay, which was similar to his older

  1. Development and Application of a Next Generation Air Sensor Network for the Hong Kong Marathon 2015 Air Quality Monitoring.

    Science.gov (United States)

    Sun, Li; Wong, Ka Chun; Wei, Peng; Ye, Sheng; Huang, Hao; Yang, Fenhuan; Westerdahl, Dane; Louie, Peter K K; Luk, Connie W Y; Ning, Zhi

    2016-02-05

    This study presents the development and evaluation of a next generation air monitoring system with both laboratory and field tests. A multi-parameter algorithm was used to correct for the impact of environmental conditions on the electrochemical sensors for carbon monoxide (CO) and nitrogen dioxide (NO2) pollutants. The field evaluation in an urban roadside environment in comparison to designated monitors showed good agreement with measurement error within 5% of the pollutant concentrations. Multiple sets of the developed system were then deployed in the Hong Kong Marathon 2015 forming a sensor-based network along the marathon route. Real-time air pollution concentration data were wirelessly transmitted and the Air Quality Health Index (AQHI) for the Green Marathon was calculated, which were broadcast to the public on an hourly basis. The route-specific sensor network showed somewhat different pollutant patterns than routine air monitoring, indicating the immediate impact of traffic control during the marathon on the roadside air quality. The study is one of the first applications of a next generation sensor network in international sport events, and it demonstrated the usefulness of the emerging sensor-based air monitoring technology in rapid network deployment to supplement existing air monitoring.

  2. Development of next generation tempered and ODS reduced activation ferritic/martensitic steels for fusion energy applications

    Science.gov (United States)

    Zinkle, S. J.; Boutard, J. L.; Hoelzer, D. T.; Kimura, A.; Lindau, R.; Odette, G. R.; Rieth, M.; Tan, L.; Tanigawa, H.

    2017-09-01

    Reduced activation ferritic/martensitic steels are currently the most technologically mature option for the structural material of proposed fusion energy reactors. Advanced next-generation higher performance steels offer the opportunity for improvements in fusion reactor operational lifetime and reliability, superior neutron radiation damage resistance, higher thermodynamic efficiency, and reduced construction costs. The two main strategies for developing improved steels for fusion energy applications are based on (1) an evolutionary pathway using computational thermodynamics modelling and modified thermomechanical treatments (TMT) to produce higher performance reduced activation ferritic/martensitic (RAFM) steels and (2) a higher risk, potentially higher payoff approach based on powder metallurgy techniques to produce very high strength oxide dispersion strengthened (ODS) steels capable of operation to very high temperatures and with potentially very high resistance to fusion neutron-induced property degradation. The current development status of these next-generation high performance steels is summarized, and research and development challenges for the successful development of these materials are outlined. Material properties including temperature-dependent uniaxial yield strengths, tensile elongations, high-temperature thermal creep, Charpy impact ductile to brittle transient temperature (DBTT) and fracture toughness behaviour, and neutron irradiation-induced low-temperature hardening and embrittlement and intermediate-temperature volumetric void swelling (including effects associated with fusion-relevant helium and hydrogen generation) are described for research heats of the new steels.

  3. Development and Application of a Next Generation Air Sensor Network for the Hong Kong Marathon 2015 Air Quality Monitoring

    Directory of Open Access Journals (Sweden)

    Li Sun

    2016-02-01

    Full Text Available This study presents the development and evaluation of a next generation air monitoring system with both laboratory and field tests. A multi-parameter algorithm was used to correct for the impact of environmental conditions on the electrochemical sensors for carbon monoxide (CO and nitrogen dioxide (NO2 pollutants. The field evaluation in an urban roadside environment in comparison to designated monitors showed good agreement with measurement error within 5% of the pollutant concentrations. Multiple sets of the developed system were then deployed in the Hong Kong Marathon 2015 forming a sensor-based network along the marathon route. Real-time air pollution concentration data were wirelessly transmitted and the Air Quality Health Index (AQHI for the Green Marathon was calculated, which were broadcast to the public on an hourly basis. The route-specific sensor network showed somewhat different pollutant patterns than routine air monitoring, indicating the immediate impact of traffic control during the marathon on the roadside air quality. The study is one of the first applications of a next generation sensor network in international sport events, and it demonstrated the usefulness of the emerging sensor-based air monitoring technology in rapid network deployment to supplement existing air monitoring.

  4. DOE seeks applicants to develop next-generation nuclear detectors. (Sensors)

    CERN Multimedia

    2002-01-01

    "DOE's Division of High Energy Physics seeks grant applications for development of advanced detectors in the areas of high energy physics experiments, which includes accelerator-based and non-accelerator based experiments" (1/2 page).

  5. Monet: a next-generation database kernel for query-intensive applications

    NARCIS (Netherlands)

    P.A. Boncz (Peter)

    2002-01-01

    htmlabstractMonet is a database kernel targeted at query-intensive, heavy analysis applications (the opposite of transaction processing), which include OLAP and data mining, but also go beyond the business domain in GIS processing, multi-media retrieval and XML. The clean sheet approach of Monet

  6. Application of mechanistic models to fermentation and biocatalysis for next-generation processes

    DEFF Research Database (Denmark)

    Gernaey, Krist; Eliasson Lantz, Anna; Tufvesson, Pär

    2010-01-01

    Mechanistic models are based on deterministic principles, and recently, interest in them has grown substantially. Herein we present an overview of mechanistic models and their applications in biotechnology, including future perspectives. Model utility is highlighted with respect to selection of v...

  7. Building upon Historical Competencies: Next-generation Clean-up Technologies for World-Wide Application - 13368

    Energy Technology Data Exchange (ETDEWEB)

    Guevara, K.C. [DOE Savannah River Operations Office, Aiken, South Carolina 29808 (United States); Fellinger, A.P.; Aylward, R.S.; Griffin, J.C.; Hyatt, J.E.; Bush, S.R. [Savannah River National Laboratory, Aiken, South Carolina 29808 (United States)

    2013-07-01

    The Department of Energy's Savannah River Site has a 60-year history of successfully operating nuclear facilities and cleaning up the nuclear legacy of the Cold War era through the processing of radioactive and otherwise hazardous wastes, remediation of contaminated soil and groundwater, management of nuclear materials, and deactivation and decommissioning of excess facilities. SRS recently unveiled its Enterprise.SRS (E.SRS) strategic vision to identify and facilitate application of the historical competencies of the site to current and future national and global challenges. E.SRS initiatives such as the initiative to Develop and Demonstrate Next generation Clean-up Technologies seek timely and mutually beneficial engagements with entities around the country and the world. One such ongoing engagement is with government and industry in Japan in the recovery from the devastation of the Fukushima Daiichi Nuclear Power Station. (authors)

  8. Next generation nutraceutical from shrimp waste: The convergence of applications with extraction methods.

    Science.gov (United States)

    Prameela, Kandra; Venkatesh, Kuncham; Immandi, Sarat Babu; Kasturi, Ashok Phani Kiran; Rama Krishna, Ch; Murali Mohan, Ch

    2017-12-15

    In recent years considerable progress in health therapy makes a significant improvement in natural nutraceuticals. Shrimp is a valuable natural sea food and is processed by removing head, tail and carapace as waste. The large amounts of waste produced by sea food industries capitulate, recoverable nutraceutical compound astaxanthin. This review emphasizes the chemistry and role of astaxanthin in pigmentation. The study highlights progress in applications and describes the current extraction methods starting with chemical to the best eco-friendly microbial processes. Relevant literature on the methods giving summary of results obtained using each approach has been reviewed and critically discussed. Intense research in advancing extraction methods to enhance productivity and to meet the demands of the consumer was discussed in future challenges. Further, aimed at collating valuable information about applications and recent extraction methodologies will promote a concept of intake of "a nutraceutical a day may keep the doctor away". Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Cognitive Radio and its Application for Next Generation Cellular and Wireless Networks

    CERN Document Server

    Muntean, Gabriel-Miro

    2012-01-01

    This book provides a broad introduction to Cognitive Radio, which attempts to mimic human cognition and reasoning applied to Software Defined Radio and reconfigurable radio over wireless networks.  It provides readers with significant technical and practical insights into different aspects of Cognitive Radio, starting from a basic background, the principle behind the technology, the inter-related technologies and application to cellular and vehicular networks, the technical challenges, implementation and future trends.  The discussion balances theoretical concepts and practical implementation. Wherever feasible, the different concepts explained are linked to application of the corresponding scheme in a particular wireless standard.     This book has two sections: the first section begins with an introduction to cognitive radio and discusses in detail various, inter-dependent technologies such as network coding, software-based radio, dirty RF, etc. and their relation to cognitive radio. The second section ...

  10. Nanoarchitectured graphene-based supercapacitors for next-generation energy-storage applications.

    Science.gov (United States)

    Salunkhe, Rahul R; Lee, Ying-Hui; Chang, Kuo-Hsin; Li, Jing-Mei; Simon, Patrice; Tang, Jing; Torad, Nagy L; Hu, Chi-Chang; Yamauchi, Yusuke

    2014-10-20

    Tremendous development in the field of portable electronics and hybrid electric vehicles has led to urgent and increasing demand in the field of high-energy storage devices. In recent years, many research efforts have been made for the development of more efficient energy-storage devices such as supercapacitors, batteries, and fuel cells. In particular, supercapacitors have great potential to meet the demands of both high energy density and power density in many advanced technologies. For the last half decade, graphene has attracted intense research interest for electrical double-layer capacitor (EDLC) applications. The unique electronic, thermal, mechanical, and chemical characteristics of graphene, along with the intrinsic benefits of a carbon material, make it a promising candidate for supercapacitor applications. This Review focuses on recent research developments in graphene-based supercapacitors, including doped graphene, activated graphene, graphene/metal oxide composites, graphene/polymer composites, and graphene-based asymmetric supercapacitors. The challenges and prospects of graphene-based supercapacitors are also discussed. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. EIGER: Next generation single photon counting detector for X-ray applications

    International Nuclear Information System (INIS)

    Dinapoli, Roberto; Bergamaschi, Anna; Henrich, Beat; Horisberger, Roland; Johnson, Ian; Mozzanica, Aldo; Schmid, Elmar; Schmitt, Bernd; Schreiber, Akos; Shi, Xintian; Theidel, Gerd

    2011-01-01

    EIGER is an advanced family of single photon counting hybrid pixel detectors, primarily aimed at diffraction experiments at synchrotrons. Optimization of maximal functionality and minimal pixel size (using a 0.25μm process and conserving the radiation tolerant design) has resulted in 75x75μm 2 pixels. Every pixel comprises a preamplifier, shaper, discriminator (with a 6 bit DAC for threshold trimming), a configurable 4/8/12 bit counter with double buffering, as well as readout, control and test circuitry. A novel feature of this chip is its double buffered counter, meaning a next frame can be acquired while the previous one is being readout. An array of 256x256 pixels fits on a ∼2x2cm 2 chip and a sensor of ∼8x4cm 2 will be equipped with eight readout chips to form a module containing 0.5 Mpixel. Several modules can then be tiled to form larger area detectors. Detectors up to 4x8 modules (16 Mpixel) are planned. To achieve frame rates of up to 24 kHz the readout architecture is highly parallel, and the chip readout happens in parallel on 32 readout lines with a 100 MHz Double Data Rate clock. Several chips and singles (i.e. a single chip bump-bonded to a single chip silicon sensor) were tested both with a lab X-ray source and at Swiss Light Source (SLS) beamlines. These tests demonstrate the full functionality of the chip and provide a first assessment of its performance. High resolution X-ray images and 'high speed movies' were produced, even without threshold trimming, at the target system frame rates (up to ∼24kHz in 4 bit mode). In parallel, dedicated hardware, firmware and software had to be developed to comply with the enormous data rate the chip is capable of delivering. Details of the chip design and tests will be given, as well as highlights of both test and final readout systems.

  12. Next Generation Hydro Software

    NARCIS (Netherlands)

    Donchyts, G.; Baart, F.; Van Dam, A.; De Goede, E.; Icke, J.; Putten, H.

    2014-01-01

    An overview paper, describes motivation and main deliverables of the Next Generation Hydro Software (NGHS) project. Important technological innovations include development of the new computational core Delft3D Flexible Mesh, as well as the open modelling environment Delta Shell.

  13. Capabilities needed for the next generation of thermo-hydraulic codes for use in real time applications

    Energy Technology Data Exchange (ETDEWEB)

    Arndt, S.A.

    1997-07-01

    The real-time reactor simulation field is currently at a crossroads in terms of the capability to perform real-time analysis using the most sophisticated computer codes. Current generation safety analysis codes are being modified to replace simplified codes that were specifically designed to meet the competing requirement for real-time applications. The next generation of thermo-hydraulic codes will need to have included in their specifications the specific requirement for use in a real-time environment. Use of the codes in real-time applications imposes much stricter requirements on robustness, reliability and repeatability than do design and analysis applications. In addition, the need for code use by a variety of users is a critical issue for real-time users, trainers and emergency planners who currently use real-time simulation, and PRA practitioners who will increasingly use real-time simulation for evaluating PRA success criteria in near real-time to validate PRA results for specific configurations and plant system unavailabilities.

  14. Capabilities needed for the next generation of thermo-hydraulic codes for use in real time applications

    International Nuclear Information System (INIS)

    Arndt, S.A.

    1997-01-01

    The real-time reactor simulation field is currently at a crossroads in terms of the capability to perform real-time analysis using the most sophisticated computer codes. Current generation safety analysis codes are being modified to replace simplified codes that were specifically designed to meet the competing requirement for real-time applications. The next generation of thermo-hydraulic codes will need to have included in their specifications the specific requirement for use in a real-time environment. Use of the codes in real-time applications imposes much stricter requirements on robustness, reliability and repeatability than do design and analysis applications. In addition, the need for code use by a variety of users is a critical issue for real-time users, trainers and emergency planners who currently use real-time simulation, and PRA practitioners who will increasingly use real-time simulation for evaluating PRA success criteria in near real-time to validate PRA results for specific configurations and plant system unavailabilities

  15. Highly Flexible, Fire Resistant HybridSil Foams for Next Generation Fireproofing, Insulation, and Energy Absorption NASA Applications, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of this Phase I STTR program is to adapt NanoSonic's HybridSil™ nanocomposite technology for the creation of next generation highly flexible, fire...

  16. Next generation mobile broadcasting

    CERN Document Server

    Gómez-Barquero, David

    2013-01-01

    Next Generation Mobile Broadcasting provides an overview of the past, present, and future of mobile multimedia broadcasting. The first part of the book-Mobile Broadcasting Worldwide-summarizes next-generation mobile broadcasting technologies currently available. This part covers the evolutions of the Japanese mobile broadcasting standard ISDB-T One-Seg, ISDB-Tmm and ISDB-TSB; the evolution of the South Korean T-DMB mobile broadcasting technology AT-DMB; the American mobile broadcasting standard ATSC-M/H; the Chinese broadcasting technologies DTMB and CMMB; second-generation digital terrestrial

  17. First Demonstration of Real-Time End-to-End 40 Gb/s PAM-4 System using 10-G Transmitter for Next Generation Access Applications

    DEFF Research Database (Denmark)

    Wei, Jinlong; Eiselt, Nicklas; Griesser, Helmut

    We demonstrate the first known experiment of a real-time end-to-end 40-Gb/s PAM-4 system for next generation access applications using 10G class transmitters only. Up to 25-dB upstream link budget for 20 km SMF is achieved.......We demonstrate the first known experiment of a real-time end-to-end 40-Gb/s PAM-4 system for next generation access applications using 10G class transmitters only. Up to 25-dB upstream link budget for 20 km SMF is achieved....

  18. Two-zone SiGe base heterojunction bipolar charge plasma transistor for next generation analog and RF applications

    Science.gov (United States)

    Bramhane, Lokesh Kumar; Singh, Jawar

    2017-01-01

    For next generation terahertz applications, heterojunction bipolar transistor (HBT) with reduced dimensions and charge plasma (CP) can be a potential candidate due to simplified and inexpensive process. In this paper, a symmetric lateral two-zone SiGe base heterojunction bipolar charge plasma transistor (HBCPT) with an extruded (extended) base is proposed and its performance at circuit level is studied. The linearly graded electric field in the proposed HBCPT provides improved self gain (β) and cut-off frequency (fT). Two-dimensional (2-D) TCAD and small-signal model based simulations of the proposed HBCPT demonstrates high self gain β 35-172.93 and fT of 1-4 THz for different device parameters. Moreover, fT of 1104.9 GHz and β of 35 can be achieved by decreasing Nb up to 8.2 ×1017cm-3 . Although, fT of 2 THz and 4 THz can also be achieved by reducing the base resistance up to 10 Ω and increasing the emitter/collector length up to 63 nm, respectively. The small-signal analysis of common-emitter amplifier based on the proposed HBCPT demonstrate high voltage gain of 50.11 as compared to conventional HBT (18.1).

  19. Next Generation Sequencing of Chromosome-Specific Libraries Sheds Light on Genome Evolution in Paleotetraploid Sterlet (Acipenser ruthenus).

    Science.gov (United States)

    Andreyushkova, Daria A; Makunin, Alexey I; Beklemisheva, Violetta R; Romanenko, Svetlana A; Druzhkova, Anna S; Biltueva, Larisa B; Serdyukova, Natalya A; Graphodatsky, Alexander S; Trifonov, Vladimir A

    2017-11-10

    Several whole genome duplication (WGD) events followed by rediploidization took place in the evolutionary history of vertebrates. Acipenserids represent a convenient model group for investigation of the consequences of WGD as their representatives underwent additional WGD events in different lineages resulting in ploidy level variation between species, and these processes are still ongoing. Earlier, we obtained a set of sterlet (Acipenser ruthenus) chromosome-specific libraries by microdissection and revealed that they painted two or four pairs of whole sterlet chromosomes, as well as additional chromosomal regions, depending on rediploidization status and chromosomal rearrangements after genome duplication. In this study, we employed next generation sequencing to estimate the content of libraries derived from different paralogous chromosomes of sterlet. For this purpose, we aligned the obtained reads to the spotted gar (Lepisosteus oculatus) reference genome to reveal syntenic regions between these two species having diverged 360 Mya. We also showed that the approach is effective for synteny prediction at various evolutionary distances and allows one to clearly distinguish paralogous chromosomes in polyploid genomes. We postulated that after the acipenserid-specific WGD sterlet karyotype underwent multiple interchromosomal rearrangements, but different chromosomes were involved in this process unequally.

  20. Next generation of accelerators

    International Nuclear Information System (INIS)

    Richter, B.

    1979-01-01

    Existing high-energy accelerators are reviewed, along with those under construction or being designed. Finally, some of the physics issues which go into setting machine parameters, and some of the features of the design of next generation electron and proton machines are discussed

  1. Next Generation Inverter

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Zilai [General Motors LLC, Detroit, MI (United States); Gough, Charles [General Motors LLC, Detroit, MI (United States)

    2016-04-22

    The goal of this Cooperative Agreement was the development of a Next Generation Inverter for General Motors’ electrified vehicles, including battery electric vehicles, range extended electric vehicles, plug-in hybrid electric vehicles and hybrid electric vehicles. The inverter is a critical electronics component that converts battery power (DC) to and from the electric power for the motor (AC).

  2. Next Generation Microchannel Heat Exchangers

    CERN Document Server

    Ohadi, Michael; Dessiatoun, Serguei; Cetegen, Edvin

    2013-01-01

    In Next Generation Microchannel Heat Exchangers, the authors’ focus on the new generation highly efficient heat exchangers and presentation of novel data and technical expertise not available in the open literature.  Next generation micro channels offer record high heat transfer coefficients with pressure drops much less than conventional micro channel heat exchangers. These inherent features promise fast penetration into many mew markets, including high heat flux cooling of electronics, waste heat recovery and energy efficiency enhancement applications, alternative energy systems, as well as applications in mass exchangers and chemical reactor systems. The combination of up to the minute research findings and technical know-how make this book very timely as the search for high performance heat and mass exchangers that can cut costs in materials consumption intensifies.

  3. Searching for light Higgs scalar boson in the next generation of electron-positron collider at LEP

    International Nuclear Information System (INIS)

    Chukwumah, G.C.

    1985-11-01

    The e + e - -collider facilities at LEP II, with the cm energy √S in the range 100-170 GeV may be able to detect ''light'' Higgs bosons, assuming a high luminosity. In this paper, we have calculated production cross-sections of a light Higgs boson H 0 in association with the neutral gauge boson Z 0 , for varying ranges of the cm energy expected to be available to LEP II and VLEEP (Novosibirsk) and for various values of the light Higgs mass. It is found out that production cross-sections are sizeable in comparison with those for the very massive Higgs bosons in proton-anti(proton) super-colliders, Tevatron, Spp-barS and SSC, respectively. The implication of this feature is pointed out. Further, prospects for light Higgs production in association with the charged gauge boson, W - in ultra energetic neutrino beams are examined. (author)

  4. The Next Generation Photoinjector

    Energy Technology Data Exchange (ETDEWEB)

    Palmer, Dennis Thomas; /Stanford U., Appl. Phys. Dept.

    2005-09-12

    This dissertation will elucidate the design, construction, theory, and operation of the Next Generation Photoinjector (NGP). This photoinjector is comprised of the BNL/SLAC/UCLA 1.6 cell symmetrized S-band photocathode radio frequency (rf) electron gun and a single emittance-compensation solenoidal magnet. This photoinjector is a prototype for the Linear Coherent Light Source X-ray Free Electron Laser operating in the 1.5 {angstrom} range. Simulations indicate that this photoinjector is capable of producing a 1nC electron bunch with transverse normalized emittance less than 1 {pi} mm mrad were the cathode is illuminated with a 10 psec longitudinal flat top pulse. Using a Gaussian longitudinal laser profile with a full width half maximum (FWHM) of 10 psec, simulation indicates that the NGP is capable of producing a normalized rms emittance of 2.50 {pi} mm mrad at 1 nC. Using the removable cathode plate we have studied the quantum efficiency (QE) of both copper and magnesium photo-cathodes. The Cu QE was found to be 4.5 x 10{sup -5} with a 25% variation in the QE across the emitting surface of the cathode, while supporting a field gradient of 125 MV/m. At low charge, the transverse normalized rms emittance, {epsilon}{sub n,rms}, produced by the NGP is {epsilon}{sub n,rms} = 1.2 {pi} mm mrad for Q{sub T} = 0.3 nC. The 95% electron beam bunch length was measured to 10.9 psec. The emittance due to the finite magnetic field at the cathode has been studied. The scaling of this magnetic emittance term as a function of cathode magnetic field was found to be 0.01 {pi} mm mrad per Gauss. The 1.6 cell rf gun has been designed to reduce the dipole field asymmetry of the longitudinal accelerating field. Low level rf measurements show that this has in fact been accomplished, with an order of magnitude decrease in the dipole field. High power beam studies also show that the dipole field has been decreased. An upper limit of the intrinsic non-reducible thermal emittance of a

  5. The Application of Next-Generation Sequencing for Mutation Detection in Autosomal-Dominant Hereditary Hearing Impairment.

    Science.gov (United States)

    Gürtler, Nicolas; Röthlisberger, Benno; Ludin, Katja; Schlegel, Christoph; Lalwani, Anil K

    2017-07-01

    Identification of the causative mutation using next-generation sequencing in autosomal-dominant hereditary hearing impairment, as mutation analysis in hereditary hearing impairment by classic genetic methods, is hindered by the high heterogeneity of the disease. Two Swiss families with autosomal-dominant hereditary hearing impairment. Amplified DNA libraries for next-generation sequencing were constructed from extracted genomic DNA, derived from peripheral blood, and enriched by a custom-made sequence capture library. Validated, pooled libraries were sequenced on an Illumina MiSeq instrument, 300 cycles and paired-end sequencing. Technical data analysis was performed with SeqMonk, variant analysis with GeneTalk or VariantStudio. The detection of mutations in genes related to hearing loss by next-generation sequencing was subsequently confirmed using specific polymerase-chain-reaction and Sanger sequencing. Mutation detection in hearing-loss-related genes. The first family harbored the mutation c.5383+5delGTGA in the TECTA-gene. In the second family, a novel mutation c.2614-2625delCATGGCGCCGTG in the WFS1-gene and a second mutation TCOF1-c.1028G>A were identified. Next-generation sequencing successfully identified the causative mutation in families with autosomal-dominant hereditary hearing impairment. The results helped to clarify the pathogenic role of a known mutation and led to the detection of a novel one. NGS represents a feasible approach with great potential future in the diagnostics of hereditary hearing impairment, even in smaller labs.

  6. Next Generation Social Networks

    DEFF Research Database (Denmark)

    Sørensen, Lene Tolstrup; Skouby, Knud Erik

    2008-01-01

    When it comes to discussing the future of electronic communication, social networking is the buzzword. The Internet has become a platform where new social networks emerge and the Internet it itself support the more traditional computer supported communication. The way users build and verifies...... different online networks for communities of people who share interests or individuals who presents themselves through user produced content is what makes up the social networking of today. The purpose of this paper is to discuss perceived user requirements to the next generation social networks. The paper...

  7. Next-generation sequencing

    DEFF Research Database (Denmark)

    Rieneck, Klaus; Bak, Mads; Jønson, Lars

    2013-01-01

    the feasibility of predicting the fetal KEL1 phenotype using next-generation sequencing (NGS) technology. STUDY DESIGN AND METHODS: The KEL1/2 single-nucleotide polymorphism was polymerase chain reaction (PCR) amplified with one adjoining base, and the PCR product was sequenced using a genome analyzer (GAIIx......, Illumina); several millions of PCR sequences were analyzed. RESULTS: The results demonstrated the feasibility of diagnosing the fetal KEL1 or KEL2 blood group from cell-free DNA purified from maternal plasma. CONCLUSION: This method requires only one primer pair, and the large amount of sequence...

  8. Next generation toroidal devices

    International Nuclear Information System (INIS)

    Yoshikawa, Shoichi

    1998-10-01

    A general survey of the possible approach for the next generation toroidal devices was made. Either surprisingly or obviously (depending on one's view), the technical constraints along with the scientific considerations lead to a fairly limited set of systems for the most favorable approach for the next generation devices. Specifically if the magnetic field strength of 5 T or above is to be created by superconducting coils, it imposes minimum in the aspect ratio for the tokamak which is slightly higher than contemplated now for ITER design. The similar technical constraints make the minimum linear size of a stellarator large. Scientifically, it is indicated that a tokamak of 1.5 times in the linear dimension should be able to produce economically, especially if a hybrid reactor is allowed. For the next stellarator, it is strongly suggested that some kind of helical axis is necessary both for the (almost) absolute confinement of high energy particles and high stability and equilibrium beta limits. The author still favors a heliac most. Although it may not have been clearly stated in the main text, the stability afforded by the shearless layer may be exploited fully in a stellarator. (author)

  9. Next generation CANDU plants

    International Nuclear Information System (INIS)

    Hedges, K.R.; Yu, S.K.W.

    1998-01-01

    Future CANDU designs will continue to meet the emerging design and performance requirements expected by the operating utilities. The next generation CANDU products will integrate new technologies into both the product features as well as into the engineering and construction work processes associated with delivering the products. The timely incorporation of advanced design features is the approach adopted for the development of the next generation of CANDU. AECL's current products consist of 700MW Class CANDU 6 and 900 MW Class CANDU 9. Evolutionary improvements are continuing with our CANDU products to enhance their adaptability to meet customers ever increasing need for higher output. Our key product drivers are for improved safety, environmental protection and improved cost effectiveness. Towards these goals we have made excellent progress in Research and Development and our investments are continuing in areas such as fuel channels and passive safety. Our long term focus is utilizing the fuel cycle flexibility of CANDU reactors as part of the long term energy mix

  10. Potential of the FLASH FEL technology for the construction of a kW-scale light source for the next generation lithography

    Energy Technology Data Exchange (ETDEWEB)

    Schneidmiller, E.A.; Vogel, V.F.; Weise, H.; Yurkov, M.V.

    2011-08-15

    The driving engine of the Free Electron Laser in Hamburg (FLASH) is an L-band superconducting accelerator. It is designed to operate in burst mode with 800 microsecond pulse duration at a repetition rate of 10 Hz. The maximum accelerated beam current during the macropulse is 9 mA. Our analysis shows that the FLASH technology has great potential since it is possible to construct a FLASH like free electron laser operating at the wavelength of 13.5 and 6.8 nanometer with an average power up to 2.6 kW. Such a source meets the physical requirements for the light source for the next generation lithography. (orig.)

  11. Next generation vaccines.

    Science.gov (United States)

    Riedmann, Eva M

    2011-07-01

    In February this year, about 100 delegates gathered for three days in Vienna (Austria) for the Next Generation Vaccines conference. The meeting held in the Vienna Hilton Hotel from 23rd-25th February 2011 had a strong focus on biotech and industry. The conference organizer Jacob Fleming managed to put together a versatile program ranging from the future generation of vaccines to manufacturing, vaccine distribution and delivery, to regulatory and public health issues. Carefully selected top industry experts presented first-hand experience and shared solutions for overcoming the latest challenges in the field of vaccinology. The program also included several case study presentations on novel vaccine candidates in different stages of development. An interactive pre-conference workshop as well as interactive panel discussions during the meeting allowed all delegates to gain new knowledge and become involved in lively discussions on timely, interesting and sometimes controversial topics related to vaccines.

  12. Next generation breeding.

    Science.gov (United States)

    Barabaschi, Delfina; Tondelli, Alessandro; Desiderio, Francesca; Volante, Andrea; Vaccino, Patrizia; Valè, Giampiero; Cattivelli, Luigi

    2016-01-01

    The genomic revolution of the past decade has greatly improved our understanding of the genetic make-up of living organisms. The sequencing of crop genomes has completely changed our vision and interpretation of genome organization and evolution. Re-sequencing allows the identification of an unlimited number of markers as well as the analysis of germplasm allelic diversity based on allele mining approaches. High throughput marker technologies coupled with advanced phenotyping platforms provide new opportunities for discovering marker-trait associations which can sustain genomic-assisted breeding. The availability of genome sequencing information is enabling genome editing (site-specific mutagenesis), to obtain gene sequences desired by breeders. This review illustrates how next generation sequencing-derived information can be used to tailor genomic tools for different breeders' needs to revolutionize crop improvement. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  13. Next generation sensors and systems

    CERN Document Server

    2016-01-01

    Written by experts in their area of research, this book has outlined the current status of the fundamentals and analytical concepts, modelling and design issues, technical details and practical applications of different types of sensors and discussed about the trends of next generation of sensors and systems happening in the area of Sensing technology. This book will be useful as a reference book for engineers and scientist especially the post-graduate students find will this book as reference book for their research on wearable sensors, devices and technologies.  .

  14. Application of next-generation sequencing technology for comprehensive aneuploidy screening of blastocysts in clinical preimplantation genetic screening cycles.

    Science.gov (United States)

    Fiorentino, Francesco; Bono, Sara; Biricik, Anil; Nuccitelli, Andrea; Cotroneo, Ettore; Cottone, Giuliano; Kokocinski, Felix; Michel, Claude-Edouard; Minasi, Maria Giulia; Greco, Ermanno

    2014-12-01

    Can next-generation sequencing (NGS) techniques be used reliably for comprehensive aneuploidy screening of human embryos from patients undergoing IVF treatments, with the purpose of identifying and selecting chromosomally normal embryos for transfer? Extensive application of NGS in clinical preimplantation genetic screening (PGS) cycles demonstrates that this methodology is reliable, allowing identification and transfer of euploid embryos resulting in ongoing pregnancies. The effectiveness of PGS is dependent upon the biology of the early embryo and the limitations of the technology. Fluorescence in situ hybridization, used to test for a few chromosomes, has largely been superseded by microarray techniques that test all 24 chromosomes. Array comparative genomic hybridization (array-CGH) has been demonstrated to be an accurate PGS method and has become the de facto gold standard, but new techniques, such as NGS, continue to emerge. The study consisted of a prospective trial involving a double blind parallel evaluation, with both NGS and array-CGH techniques, of 192 blastocysts obtained from 55 consecutive clinical PGS cycles undertaken during the period of September to October 2013. Consistency of NGS-based aneuploidy detection was assessed by matching the results obtained with array-CGH-based diagnoses. Primary outcome measure was accuracy of the chromosomal analysis; secondary outcome measures were clinical outcomes. Fifty-five patients (median age 39.3 years, range 32-46) undergoing PGS were enrolled in the study. All embryos were cultured to blastocyst stage; trophectoderm biopsy was performed on Day 5 of development or Day 6/7 for slower growing embryos. The method involved whole genome amplification followed by both NGS and array-CGH. The MiSeq control software, real-time analysis and reporter performed on-board primary and secondary bioinformatics analysis. Copy number variation analysis was accomplished with BlueFuse Multi software. A total of 192

  15. Next-Generation Pathology.

    Science.gov (United States)

    Caie, Peter D; Harrison, David J

    2016-01-01

    The field of pathology is rapidly transforming from a semiquantitative and empirical science toward a big data discipline. Large data sets from across multiple omics fields may now be extracted from a patient's tissue sample. Tissue is, however, complex, heterogeneous, and prone to artifact. A reductionist view of tissue and disease progression, which does not take this complexity into account, may lead to single biomarkers failing in clinical trials. The integration of standardized multi-omics big data and the retention of valuable information on spatial heterogeneity are imperative to model complex disease mechanisms. Mathematical modeling through systems pathology approaches is the ideal medium to distill the significant information from these large, multi-parametric, and hierarchical data sets. Systems pathology may also predict the dynamical response of disease progression or response to therapy regimens from a static tissue sample. Next-generation pathology will incorporate big data with systems medicine in order to personalize clinical practice for both prognostic and predictive patient care.

  16. Next Generation Science Partnerships

    Science.gov (United States)

    Magnusson, J.

    2016-02-01

    I will provide an overview of the Next Generation Science Standards (NGSS) and demonstrate how scientists and educators can use these standards to strengthen and enhance their collaborations. The NGSS are rich in content and practice and provide all students with an internationally-benchmarked science education. Using these state-led standards to guide outreach efforts can help develop and sustain effective and mutually beneficial teacher-researcher partnerships. Aligning outreach with the three dimensions of the standards can help make research relevant for target audiences by intentionally addressing the science practices, cross-cutting concepts, and disciplinary core ideas of the K-12 science curriculum that drives instruction and assessment. Collaborations between researchers and educators that are based on this science framework are more sustainable because they address the needs of both scientists and educators. Educators are better able to utilize science content that aligns with their curriculum. Scientists who learn about the NGSS can better understand the frameworks under which educators work, which can lead to more extensive and focused outreach with teachers as partners. Based on this model, the International Ocean Discovery Program (IODP) develops its education materials in conjunction with scientists and educators to produce accurate, standards-aligned activities and curriculum-based interactions with researchers. I will highlight examples of IODP's current, successful teacher-researcher collaborations that are intentionally aligned with the NGSS.

  17. Next Generation Summer School

    Science.gov (United States)

    Eugenia, Marcu

    2013-04-01

    On 21.06.2010 the "Next Generation" Summer School has opened the doors for its first students. They were introduced in the astronomy world by astronomical observations, astronomy and radio-astronomy lectures, laboratory projects meant to initiate them into modern radio astronomy and radio communications. The didactic programme was structure as fallowing: 1) Astronomical elements from the visible spectrum (lectures + practical projects) 2) Radio astronomy elements (lectures + practical projects) 3) Radio communication base (didactic- recreative games) The students and professors accommodation was at the Agroturistic Pension "Popasul Iancului" situated at 800m from the Marisel Observatory. First day (summer solstice day) began with a practical activity: determination of the meridian by measurements of the shadow (the direction of one vertical alignment, when it has the smallest length). The experiment is very instructive and interesting because combines notions of physics, spatial geometry and basic astronomy elements. Next day the activities took place in four stages: the students processed the experimental data obtained on first day (on sheets of millimetre paper they represented the length of the shadow alignments according the time), each team realised its own sun quadrant, point were given considering the design and functionality of these quadrant, the four teams had to mimic important constellations on carton boards with phosphorescent sticky stars and the students, accompanied by the professors took a hiking trip to the surroundings, marking the interest point coordinates, using a GPS to establish the geographical coronations and at the end of the day the students realised a small map of central Marisel area based on the GPS data. On the third day, the students were introduced to basic notions of radio astronomy, the principal categories of artificial Earth satellites: low orbit satellites (LEO), Medium orbit satellites (MEO) and geostationary satellites (GEO

  18. Next generation information systems

    International Nuclear Information System (INIS)

    Limback, Nathan P.; Medina, Melanie A.; Silva, Michelle E.

    2010-01-01

    The Information Systems Analysis and Development (ISAD) Team of the Safeguards Systems Group at Los Alamos National Laboratory (LANL) has been developing web based information and knowledge management systems for sixteen years. Our vision is to rapidly and cost effectively provide knowledge management solutions in the form of interactive information systems that help customers organize, archive, post and retrieve nonproliferation and safeguards knowledge and information vital to their success. The team has developed several comprehensive information systems that assist users in the betterment and growth of their organizations and programs. Through our information systems, users are able to streamline operations, increase productivity, and share and access information from diverse geographic locations. The ISAD team is also producing interactive visual models. Interactive visual models provide many benefits to customers beyond the scope of traditional full-scale modeling. We have the ability to simulate a vision that a customer may propose, without the time constraints of traditional engineering modeling tools. Our interactive visual models can be used to access specialized training areas, controlled areas, and highly radioactive areas, as well as review site-specific training for complex facilities, and asset management. Like the information systems that the ISAD team develops, these models can be shared and accessed from any location with access to the internet. The purpose of this paper is to elaborate on the capabilities of information systems and interactive visual models as well as consider the possibility of combining the two capabilities to provide the next generation of infonnation systems. The collection, processing, and integration of data in new ways can contribute to the security of the nation by providing indicators and information for timely action to decrease the traditional and new nuclear threats. Modeling and simulation tied to comprehensive

  19. Next Generation Wind Turbine

    Energy Technology Data Exchange (ETDEWEB)

    Cheraghi, S. Hossein [Western New England Univ., Springfield, MA (United States); Madden, Frank [FloDesign Wind Turbine Corp., Waltham, MA (United States)

    2012-09-01

    The goal of this collaborative effort between Western New England University's College of Engineering and FloDesign Wind Turbine (FDWT) Corporation to wok on a novel areodynamic concept that could potentially lead to the next generation of wind turbines. Analytical studies and early scale model tests of FDWT's Mixer/Ejector Wind Turbine (MEWT) concept, which exploits jet-age advanced fluid dynamics, indicate that the concept has the potential to significantly reduce the cost of electricity over conventional Horizontal Axis Wind Turbines while reducing land usage. This project involved the design, fabrication, and wind tunnel testing of components of MEWT to provide the research and engineering data necessary to validate the design iterations and optimize system performance. Based on these tests, a scale model prototype called Briza was designed, fabricated, installed and tested on a portable tower to investigate and improve the design system in real world conditions. The results of these scale prototype efforts were very promising and have contributed significantly to FDWT's ongoing development of a product scale wind turbine for deployment in multiple locations around the U.S. This research was mutually beneficial to Western New England University, FDWT, and the DOE by utilizing over 30 student interns and a number of faculty in all efforts. It brought real-world wind turbine experience into the classroom to further enhance the Green Engineering Program at WNEU. It also provided on-the-job training to many students, improving their future employment opportunities, while also providing valuable information to further advance FDWT's mixer-ejector wind turbine technology, creating opportunities for future project innovation and job creation.

  20. BULK FLOWS FROM GALAXY LUMINOSITIES: APPLICATION TO 2MASS REDSHIFT SURVEY AND FORECAST FOR NEXT-GENERATION DATA SETS

    International Nuclear Information System (INIS)

    Nusser, Adi; Branchini, Enzo; Davis, Marc

    2011-01-01

    We present a simple method for measuring cosmological bulk flows from large redshift surveys, based on the apparent dimming or brightening of galaxies due to their peculiar motion. It is aimed at estimating bulk flows of cosmological volumes containing large numbers of galaxies. Constraints on the bulk flow are obtained by minimizing systematic variations in galaxy luminosities with respect to a reference luminosity function measured from the whole survey. This method offers two advantages over more popular bulk flow estimators: it is independent of error-prone distance indicators and of the poorly known galaxy bias. We apply the method to the Two Micron All Sky Survey redshift survey to measure the local bulk flows of spherical shells centered on the Milky Way (MW). The result is consistent with that obtained by Nusser and Davis using the SFI++ catalogue of Tully-Fisher distance indicators. We also make an assessment of the ability of the method to constrain bulk flows at larger redshifts (z = 0.1-0.5) from next-generation data sets. As a case study we consider the planned EUCLID survey. Using this method we will be able to measure a bulk motion of ∼200 km s -1 of 10 6 galaxies with photometric redshifts, at the 3σ level for both z ∼ 0.15 and z ∼ 0.5. Thus, the method will allow us to put strong constraints on dark energy models as well as alternative theories for structure formation.

  1. Targeted next generation sequencing application in cardiac channelopathies: Analysis of a cohort of autopsy-negative sudden unexplained deaths.

    Science.gov (United States)

    Farrugia, A; Keyser, C; Hollard, C; Raul, J S; Muller, J; Ludes, B

    2015-09-01

    Genetic testing for cardiac channelopathies in sudden unexplained death (SUD) has developed substantially over the last years. The Next Generation Sequencing (NGS) technology provides an unprecedented opportunity to screen for genetic variations underlying arrhythmogenic genes in a short period of time at a low cost. The present study aimed to perform genetic testing with NGS technologies on the Ion Torrent Personal Genome Machine™ (Ion PGM™) sequencer, in targeting a total of 23 genes reported to be associated with inherited cardiac channelopathies in order to identify the possible cause of death in a cohort of post-mortem cases. The molecular analyses focused on 16 cases of SUD, aged less than 35 years old. In all cases, the cause of death could not be determined after a rigorous autopsy associated with histopathological and toxicological analyses according to the guidelines of the Association for European Cardiovascular Pathology. DNA was extracted from fresh frozen tissue. An average of 200 variants was identified per case. However, after the prioritization process using a new scoring program (VaRank) and after the conjunction of clinical data and molecular findings, four "likely pathogenic" variants (including two undescribed variants), were identified in three cases (18.75%) of our cohort in the genes KCNH2, ANK2, SCN5A and RYR2. One case, who died during psychiatric hospitalization after administration of a QT prolonging drug, showed a double "likely pathogenic" variant in Long QT genes (ANK2 and SCN5A) which may have predisposed to drug-induced cardiac arrhythmias. Our study illustrates that the NGS approach based on AmpliSeq™ libraries and Ion Torrent PGM™ sequencing may be an efficient approach, integrated to post-mortem examination. Given the massive amount of information generated by NGS, a rigorous filtration strategy of variants coupled with multidisciplinary collaboration is crucial to determine the potential pathogenic role of identified

  2. A Review on the Applications of Next Generation Sequencing Technologies as Applied to Food-Related Microbiome Studies

    Directory of Open Access Journals (Sweden)

    Yu Cao

    2017-09-01

    Full Text Available The development of next generation sequencing (NGS techniques has enabled researchers to study and understand the world of microorganisms from broader and deeper perspectives. The contemporary advances in DNA sequencing technologies have not only enabled finer characterization of bacterial genomes but also provided deeper taxonomic identification of complex microbiomes which in its genomic essence is the combined genetic material of the microorganisms inhabiting an environment, whether the environment be a particular body econiche (e.g., human intestinal contents or a food manufacturing facility econiche (e.g., floor drain. To date, 16S rDNA sequencing, metagenomics and metatranscriptomics are the three basic sequencing strategies used in the taxonomic identification and characterization of food-related microbiomes. These sequencing strategies have used different NGS platforms for DNA and RNA sequence identification. Traditionally, 16S rDNA sequencing has played a key role in understanding the taxonomic composition of a food-related microbiome. Recently, metagenomic approaches have resulted in improved understanding of a microbiome by providing a species-level/strain-level characterization. Further, metatranscriptomic approaches have contributed to the functional characterization of the complex interactions between different microbial communities within a single microbiome. Many studies have highlighted the use of NGS techniques in investigating the microbiome of fermented foods. However, the utilization of NGS techniques in studying the microbiome of non-fermented foods are limited. This review provides a brief overview of the advances in DNA sequencing chemistries as the technology progressed from first, next and third generations and highlights how NGS provided a deeper understanding of food-related microbiomes with special focus on non-fermented foods.

  3. Construction of a virtual Mycobacterium tuberculosis consensus genome and its application to data from a next generation sequencer.

    Science.gov (United States)

    Okumura, Kayo; Kato, Masako; Kirikae, Teruo; Kayano, Mitsunori; Miyoshi-Akiyama, Tohru

    2015-03-20

    Although Mycobacterium tuberculosis isolates are consisted of several different lineages and the epidemiology analyses are usually assessed relative to a particular reference genome, M. tuberculosis H37Rv, which might introduce some biased results. Those analyses are essentially based genome sequence information of M. tuberculosis and could be performed in sillico in theory, with whole genome sequence (WGS) data available in the databases and obtained by next generation sequencers (NGSs). As an approach to establish higher resolution methods for such analyses, whole genome sequences of the M. tuberculosis complexes (MTBCs) strains available on databases were aligned to construct virtual reference genome sequences called the consensus sequence (CS), and evaluated its feasibility in in sillico epidemiological analyses. The consensus sequence (CS) was successfully constructed and utilized to perform phylogenetic analysis, evaluation of read mapping efficacy, which is crucial for detecting single nucleotide polymorphisms (SNPs), and various MTBC typing methods virtually including spoligotyping, VNTR, Long sequence polymorphism and Beijing typing. SNPs detected based on CS, in comparison with H37Rv, were utilized in concatemer-based phylogenetic analysis to determine their reliability relative to a phylogenetic tree based on whole genome alignment as the gold standard. Statistical comparison of phylogenic trees based on CS with that of H37Rv indicated the former showed always better results that that of later. SNP detection and concatenation with CS was advantageous because the frequency of crucial SNPs distinguishing among strain lineages was higher than those of H37Rv. The number of SNPs detected was lower with the consensus than with the H37Rv sequence, resulting in a significant reduction in computational time. Performance of each virtual typing was satisfactory and accorded with those published when those are available. These results indicated that virtual CS

  4. Houston Methodist variant viewer: An application to support clinical laboratory interpretation of next-generation sequencing data for cancer

    Directory of Open Access Journals (Sweden)

    Paul A Christensen

    2017-01-01

    Full Text Available Introduction: Next-generation-sequencing (NGS is increasingly used in clinical and research protocols for patients with cancer. NGS assays are routinely used in clinical laboratories to detect mutations bearing on cancer diagnosis, prognosis and personalized therapy. A typical assay may interrogate 50 or more gene targets that encompass many thousands of possible gene variants. Analysis of NGS data in cancer is a labor-intensive process that can become overwhelming to the molecular pathologist or research scientist. Although commercial tools for NGS data analysis and interpretation are available, they are often costly, lack key functionality or cannot be customized by the end user. Methods: To facilitate NGS data analysis in our clinical molecular diagnostics laboratory, we created a custom bioinformatics tool termed Houston Methodist Variant Viewer (HMVV. HMVV is a Java-based solution that integrates sequencing instrument output, bioinformatics analysis, storage resources and end user interface. Results: Compared to the predicate method used in our clinical laboratory, HMVV markedly simplifies the bioinformatics workflow for the molecular technologist and facilitates the variant review by the molecular pathologist. Importantly, HMVV reduces time spent researching the biological significance of the variants detected, standardizes the online resources used to perform the variant investigation and assists generation of the annotated report for the electronic medical record. HMVV also maintains a searchable variant database, including the variant annotations generated by the pathologist, which is useful for downstream quality improvement and research projects. Conclusions: HMVV is a clinical grade, low-cost, feature-rich, highly customizable platform that we have made available for continued development by the pathology informatics community.

  5. NEXT GENERATION TURBINE PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    William H. Day

    2002-05-03

    The Next Generation Turbine (NGT) Program's technological development focused on a study of the feasibility of turbine systems greater than 30 MW that offer improvement over the 1999 state-of-the-art systems. This program targeted goals of 50 percent turndown ratios, 15 percent reduction in generation cost/kW hour, improved service life, reduced emissions, 400 starts/year with 10 minutes to full load, and multiple fuel usage. Improvement in reliability, availability, and maintainability (RAM), while reducing operations, maintenance, and capital costs by 15 percent, was pursued. This program builds on the extensive low emissions stationary gas turbine work being carried out by Pratt & Whitney (P&W) for P&W Power Systems (PWPS), which is a company under the auspices of the United Technologies Corporation (UTC). This study was part of the overall Department of Energy (DOE) NGT Program that extends out to the year 2008. A follow-on plan for further full-scale component hardware testing is conceptualized for years 2002 through 2008 to insure a smooth and efficient transition to the marketplace for advanced turbine design and cycle technology. This program teamed the National Energy Technology Laboratory (NETL), P&W, United Technologies Research Center (UTRC), kraftWork Systems Inc., a subcontractor on-site at UTRC, and Multiphase Power and Processing Technologies (MPPT), an off-site subcontractor. Under the auspices of the NGT Program, a series of analyses were performed to identify the NGT engine system's ability to serve multiple uses. The majority were in conjunction with a coal-fired plant, or used coal as the system fuel. Identified also was the ability of the NGT system to serve as the basis of an advanced performance cycle: the humid air turbine (HAT) cycle. The HAT cycle is also used with coal gasification in an integrated cycle HAT (IGHAT). The NGT systems identified were: (1) Feedwater heating retrofit to an existing coal-fired steam plant, which

  6. The Next Generation Nuclear Plant

    Energy Technology Data Exchange (ETDEWEB)

    Dr. David A. Petti

    2009-01-01

    The Next Generation Nuclear Plant (NGNP) will be a demonstration of the technical, licensing, operational, and commercial viability of High Temperature Gas-Cooled Reactor (HTGR) technology for the production of process heat, electricity, and hydrogen. This nuclear- based technology can provide high-temperature process heat (up to 950°C) that can be used as a substitute for the burning of fossil fuels for a wide range of commercial applications (see Figure 1). The substitution of the HTGR for burning fossil fuels conserves these hydrocarbon resources for other uses, reduces uncertainty in the cost and supply of natural gas and oil, and eliminates the emissions of greenhouse gases attendant with the burning of these fuels. The HTGR is a passively safe nuclear reactor concept with an easily understood safety basis that permits substantially reduced emergency planning requirements and improved siting flexibility compared to other nuclear technologies.

  7. Designing Next Generation Telecom Regulation

    DEFF Research Database (Denmark)

    Henten, Anders; Samarajiva, Rohan

    – ICT convergence regulation and multisector utility regulation. Whatever structure of next generation telecom regulation is adopted, all countries will need to pay much greater attention to the need for increased coordination of policy directions and regulatory activities both across the industries......Continuously expanding applications of information and communication technologies (ICT) are transforming local, national, regional and international economies into network economies, the foundation for information societies. They are being built upon expanded and upgraded national telecom networks...... to creating an environment to foster a massive expansion in the coverage and capabilities of the information infrastructure networks, with national telecom regulators as the key implementers of the policies of reform. The first phase of reform has focused on industry specific telecom policy and regulation...

  8. Present state of new technologies of nuclear power generation, and technological development of fast-breeder reactor and next-generation light water reactor

    International Nuclear Information System (INIS)

    Aoyagi, Toshihiro; Ando, Masato

    2014-01-01

    This paper introduces the present state of development of FBR in Japan and international cooperation, the development of HP-ABWR and HP-APWR as the next-generation light water reactors, and SMR development in the United States. As for FBR, the following situations are described: (1) history of development in Japan in the past, (2) history of change due to the readjustment of development plan caused by the accident of Fukushima Daiichi Nuclear Power Station, in which shift to FaCT phase 2 was suspended, and the approach to the establishment of safety standards for sodium-cooled FBR and its international standardization was adopted, and (3) future challenges. As for the Japan - France fast-breeder reactor development cooperation, the conclusion of the Japan - France inter-government agency agreement, and Japan's cooperation plan and system are described. Next, as for HP-ABWR and HP-APWR, the development goal and concept of each plant, and the element technologies required for the success are described. On the other hand, the small reactor development in the United States started with the aim of the securement of domestic technology base, contribution to reduction in carbon dioxide emissions, and its export to new entry countries for nuclear energy. This project aimed the practical use of SMR, and started 'financial support program for small reactors' to allocate about 452 million dollars to maximum two units of SMRs in the next five years. This project is outlined. (A.O.)

  9. Fiscal 1998 research report. Application technology of next-generation high-density energy beams; 1998 nendo chosa hokokusho. Jisedai komitsudo energy beam riyo gijutsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    Survey was made on application technologies of next- generation high-density energy beams. For real application of laser power, application to not exciting source of YAG crystal but machining directly is highly efficient. For generation of semiconductor laser high-power coherent beam, phase synchronization and summing are large technological walls. Short pulse, high intensity and high repeatability are also important. Since ultra-short pulse laser ends before heat transfer to the periphery, it is suitable for precise machining, in particular, ultra-fine machining. To use beam sources as tool for production process, development of transmission, focusing and control technologies, and optical fiber and device is indispensable. Applicable fields are as follows: machining (more than pico seconds), surface modification (modification and functionalization of tribo- materials and biocompatible materials), complex machining, fabrication of quantum functional structured materials (thin film, ultra-fine particle), agriculture, ultra-precise measurement, non-destructive measurement, and coherent chemistry in chemical and environment fields. (NEDO)

  10. Next-generation biology

    DEFF Research Database (Denmark)

    Rodrigues da Fonseca, Rute Andreia; Albrechtsen, Anders; Themudo, Goncalo Espregueira Cruz

    2016-01-01

    we present an overview of the current sequencing technologies and the methods used in typical high-throughput data analysis pipelines. Subsequently, we contextualize high-throughput DNA sequencing technologies within their applications in non-model organism biology. We include tips regarding managing...

  11. Clinical application of next generation sequencing in hereditary spinocerebellar ataxia: increasing the diagnostic yield and broadening the ataxia-spasticity spectrum. A retrospective analysis.

    Science.gov (United States)

    Galatolo, Daniele; Tessa, Alessandra; Filla, Alessandro; Santorelli, Filippo M

    2018-01-01

    One of the hardest challenges in medical genetics is to reach a molecular diagnosis in the presence of rare brain disorders. Hereditary spinocerebellar ataxia (HA), characterized by high clinical and genetic heterogeneity, is among the diseases that present this challenge. HA can have features overlapping with those of other neurological diseases, especially hereditary spastic paraplegia (HSP), as routine clinical application of next generation sequencing (NGS) has confirmed. This article reviews different NGS methods applied in heterogeneous cohorts of patients with suspected HA and suggests that exome sequencing should be considered the first-tier genetic approach in this setting. Its application lends support to the hypothesis of HA and HSP as two extremes of a continuous spectrum.

  12. Nexplanon, a radiopaque etonogestrel implant in combination with a next-generation applicator: 3-year results of a noncomparative multicenter trial.

    Science.gov (United States)

    Mommers, Ellen; Blum, Georges-Fabrice; Gent, Thomas G; Peters, Klaus P; Sørdal, Terje S; Marintcheva-Petrova, Maya

    2012-11-01

    To investigate the efficacy, safety, removal characteristics, and x-ray visibility of Nexplanon, a radiopaque etonogestrel contraceptive implant combined with a next-generation applicator. A 3-year, nocomparative, multicenter study in women aged 18-40 years at 23 clinical sites. Of 301 women who had an implant inserted, none became pregnant while the implant was in situ. Serious adverse events were reported in 16 of 301 (5.3%) women; none were judged as drug related. Fibrosis around the implant was the most common removal complication (4.4%). The implant was visible on X-ray and palpable before removal with a mean removal time of 2 minutes. Nexplanon showed high contraceptive efficacy, palpability before removal, short removal times, and few removal complications. Nexplanon provides clinicians with a long-term hormonal contraceptive method with a safety and efficacy profile comparable to Implanon, radiopacity, and a new applicator. Copyright © 2012 Mosby, Inc. All rights reserved.

  13. Next Generation Microshutter Arrays Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to develop the next generation MicroShutter Array (MSA) as a multi-object field selector for missions anticipated in the next two decades. For many...

  14. Next Generation Target Control System

    National Research Council Canada - National Science Library

    1995-01-01

    Our objective was to evaluate the allegations concerning the Next Generation Target Control System Program and to determine whether the Program is the most cost effective solution to meet the target...

  15. 78 FR 32169 - Facilitating the Deployment of Text-to-911 and Other Next Generation 911 Applications

    Science.gov (United States)

    2013-05-29

    ..., including through the use of applications downloaded on mobile phones. For interconnected text applications... for Advocacy of the Small Business Administration (SBA).\\12\\ In addition, the R&O and FRFA (or... consultation with the Office of Advocacy of the Small Business Administration and after opportunity for public...

  16. Next Generation Microbiology Requirements

    Science.gov (United States)

    Ott, C. M.; Oubre, C. M.; Elliott, T. F.; Castro, V. A.; Pierson, D. L.

    2012-01-01

    As humans continue to explore deep into space, microorganisms will travel with them. The primary means to mitigate the risk of infectious disease are a combination of prudent spacecraft design and rigorous operational controls. The effectiveness of these methods are evaluated by microbiological monitoring of spacecraft, food, water, and the crew that is performed preflight, in-flight, and post-flight. Current NASA requirements associated with microbiological monitoring are based on culture-based methodology where microorganisms are grown on a semi-solid growth medium and enumerated. Subsequent identification of the organisms requires specialized labor and large equipment, which historically has been performed on Earth. Requirements that rely strictly on culture-based units limit the use of non-culture based monitoring technology. Specifically, the culture-based "measurement criteria" are Colony Forming Units (CFU, representing the growth of one microorganism at a single location on the agar medium) per a given volume, area, or sample size. As the CFU unit by definition is culture-based, these requirements limit alternative technologies for spaceflight applications. As spaceflight missions such as those to Mars extend further into space, culture-based technology will become difficult to implement due to the (a) limited shelf life of the culture media, (b) mass/volume necessary to carry these consumables, and (c) problems associated with the production of biohazardous material in the habitable volume of the spacecraft. In addition, an extensive amount of new knowledge has been obtained during the Space Shuttle, NASA-Mir, and International Space Station Programs, which gave direction for new or modified microbial control requirements for vehicle design and mission operations. The goal of this task is to develop and recommend a new set of requirements for vehicle design and mission operations, including microbiological monitoring, based upon "lessons learned" and new

  17. Deploying Next Generation Multicast-enabled Applications Label Switched Multicast for MPLS VPNs, VPLS, and Wholesale Ethernet

    CERN Document Server

    Joseph, Vinod

    2011-01-01

    The growth, scale, and prominence of video applications over the years have placed emphasis on the most scalable and efficient way to deliver multi-play content (voice, video and data) to the end user. Multicast is the most effective and efficient carrier of video applications from a network standpoint. Financial organizations deploy large-scale multicast infrastructures to enable trading and e-commerce. The introduction of 4G and beyond makes this technology even more indispensible since mobile operators need an efficient mechanism to deliver repetitive content to many a handset, and multicas

  18. 76 FR 63257 - Facilitating the Deployment of Text-to-911 and Other Next Generation 911 Applications; Framework...

    Science.gov (United States)

    2011-10-12

    ... applications; (2) NG911 network architecture; and (3) the proper roles of the FCC, other federal agencies, and... through the media, social networking, and other sources that text, photos, and video to 911 are available... by IP-enabled network providers to ensure that such providers do not install features, functions, or...

  19. Development, Application, and Transition of Aerosol and Trace Gas Products Derived from Next-Generation Satellite Observations to Operations

    Science.gov (United States)

    Berndt, Emily; Naeger, Aaron; Zavodsky, Bradley; McGrath, Kevin; LaFontaine, Frank

    2016-01-01

    NASA Short-term Prediction Research and Transition (SPoRT) Center has a history of successfully transitioning unique observations and research capabilities to the operational weather community to improve short-term forecasts. SPoRTstrives to bridge the gap between research and operations by maintaining interactive partnerships with end users to develop products that match specific forecast challenges, provide training, and assess the products in the operational environment. This presentation focuses on recent product development, application, and transition of aerosol and trace gas products to operations for specific forecasting applications. Recent activities relating to the SPoRT ozone products, aerosol optical depth composite product, sulfur dioxide, and aerosol index products are discussed.

  20. Getting To Exascale: Applying Novel Parallel Programming Models To Lab Applications For The Next Generation Of Supercomputers

    Energy Technology Data Exchange (ETDEWEB)

    Dube, Evi [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Shereda, Charles [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Nau, Lee [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Harris, Lance [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2010-09-27

    As supercomputing moves toward exascale, node architectures will change significantly. CPU core counts on nodes will increase by an order of magnitude or more. Heterogeneous architectures will become more commonplace, with GPUs or FPGAs providing additional computational power. Novel programming models may make better use of on-node parallelism in these new architectures than do current models. In this paper we examine several of these novel models – UPC, CUDA, and OpenCL –to determine their suitability to LLNL scientific application codes. Our study consisted of several phases: We conducted interviews with code teams and selected two codes to port; We learned how to program in the new models and ported the codes; We debugged and tuned the ported applications; We measured results, and documented our findings. We conclude that UPC is a challenge for porting code, Berkeley UPC is not very robust, and UPC is not suitable as a general alternative to OpenMP for a number of reasons. CUDA is well supported and robust but is a proprietary NVIDIA standard, while OpenCL is an open standard. Both are well suited to a specific set of application problems that can be run on GPUs, but some problems are not suited to GPUs. Further study of the landscape of novel models is recommended.

  1. PARTNERSHIP FOR THE DEVELOPMENT OF NEXT GENERATION SIMULATION TOOLS TO EVALUATE CEMENTITIOUS BARRIERS AND MATERIALS USED IN NUCLEAR APPLICATION - 8388

    International Nuclear Information System (INIS)

    Langton, C; Richard Dimenna, R

    2008-01-01

    The US DOE has initiated a multidisciplinary cross cutting project to develop a reasonable and credible set of tools to predict the structural, hydraulic and chemical performance of cement barriers used in nuclear applications over extended time frames (e.g., > 100 years for operating facilities and > 1000 years for waste management). A partnership that combines DOE, NRC, academia, private sector, and international expertise has been formed to accomplish the project objectives by integrating existing information and realizing advancements where necessary. The set of simulation tools and data developed under this project will be used to evaluate and predict the behavior of cementitious barriers used in near surface engineered waste disposal systems, e.g., waste forms, containment structures, entombments and environmental remediation, including decontamination and decommissioning (D and D) activities. The simulation tools will also support analysis of structural concrete components of nuclear facilities (spent fuel pools, dry spent fuel storage units, and recycling facilities, e.g., fuel fabrication, separations processes). Simulation parameters will be obtained from prior literature and will be experimentally measured under this project, as necessary, to demonstrate application of the simulation tools for three prototype applications (waste form in concrete vault, high level waste tank grouting, and spent fuel pool). Test methods and data needs to support use of the simulation tools for future applications will be defined. This is a national issue that affects all waste disposal sites that use cementitious waste forms and structures, decontamination and decommissioning activities, service life determination of existing structures, and design of future public and private nuclear facilities. The problem is difficult because it requires projecting conditions and responses over extremely long times. Current performance assessment analyses show that engineered barriers

  2. Potential applications of micro-optic technology for next-generation fibre optic connectivity solutions exploitable in access networks

    Science.gov (United States)

    Watté, Jan; Petersen, Rainer

    2010-05-01

    The potential of fibre-optic connectivity based on micro-optical components for deployment at particular nodes of telecom access networks will be addressed. Low-cost micro-optic components which can be manufactured by high volume replication techniques can provide new functionalities or lead to optical performance improvements of permanent or demateable fibre connections. Some of the most interesting applications involving refractive micro lenses and new fibre alignment structures will be highlighted. Numerical simulations will be presented showing that expanded beam connectors are more robust to pollution than physical contact ferrule-based connectors. The advantages and drawbacks of expanded beam fibre coupling versus physical contact connectivity based on existing and micro-optical structures are discussed.

  3. Comprehensive transcriptome assembly of Chickpea (Cicer arietinum L.) using sanger and next generation sequencing platforms: development and applications.

    Science.gov (United States)

    Kudapa, Himabindu; Azam, Sarwar; Sharpe, Andrew G; Taran, Bunyamin; Li, Rong; Deonovic, Benjamin; Cameron, Connor; Farmer, Andrew D; Cannon, Steven B; Varshney, Rajeev K

    2014-01-01

    A comprehensive transcriptome assembly of chickpea has been developed using 134.95 million Illumina single-end reads, 7.12 million single-end FLX/454 reads and 139,214 Sanger expressed sequence tags (ESTs) from >17 genotypes. This hybrid transcriptome assembly, referred to as Cicer arietinumTranscriptome Assembly version 2 (CaTA v2, available at http://data.comparative-legumes.org/transcriptomes/cicar/lista_cicar-201201), comprising 46,369 transcript assembly contigs (TACs) has an N50 length of 1,726 bp and a maximum contig size of 15,644 bp. Putative functions were determined for 32,869 (70.8%) of the TACs and gene ontology assignments were determined for 21,471 (46.3%). The new transcriptome assembly was compared with the previously available chickpea transcriptome assemblies as well as to the chickpea genome. Comparative analysis of CaTA v2 against transcriptomes of three legumes - Medicago, soybean and common bean, resulted in 27,771 TACs common to all three legumes indicating strong conservation of genes across legumes. CaTA v2 was also used for identification of simple sequence repeats (SSRs) and intron spanning regions (ISRs) for developing molecular markers. ISRs were identified by aligning TACs to the Medicago genome, and their putative mapping positions at chromosomal level were identified using transcript map of chickpea. Primer pairs were designed for 4,990 ISRs, each representing a single contig for which predicted positions are inferred and distributed across eight linkage groups. A subset of randomly selected ISRs representing all eight chickpea linkage groups were validated on five chickpea genotypes and showed 20% polymorphism with average polymorphic information content (PIC) of 0.27. In summary, the hybrid transcriptome assembly developed and novel markers identified can be used for a variety of applications such as gene discovery, marker-trait association, diversity analysis etc., to advance genetics research and breeding applications in

  4. FANSe2: a robust and cost-efficient alignment tool for quantitative next-generation sequencing applications.

    Directory of Open Access Journals (Sweden)

    Chuan-Le Xiao

    Full Text Available Correct and bias-free interpretation of the deep sequencing data is inevitably dependent on the complete mapping of all mappable reads to the reference sequence, especially for quantitative RNA-seq applications. Seed-based algorithms are generally slow but robust, while Burrows-Wheeler Transform (BWT based algorithms are fast but less robust. To have both advantages, we developed an algorithm FANSe2 with iterative mapping strategy based on the statistics of real-world sequencing error distribution to substantially accelerate the mapping without compromising the accuracy. Its sensitivity and accuracy are higher than the BWT-based algorithms in the tests using both prokaryotic and eukaryotic sequencing datasets. The gene identification results of FANSe2 is experimentally validated, while the previous algorithms have false positives and false negatives. FANSe2 showed remarkably better consistency to the microarray than most other algorithms in terms of gene expression quantifications. We implemented a scalable and almost maintenance-free parallelization method that can utilize the computational power of multiple office computers, a novel feature not present in any other mainstream algorithm. With three normal office computers, we demonstrated that FANSe2 mapped an RNA-seq dataset generated from an entire Illunima HiSeq 2000 flowcell (8 lanes, 608 M reads to masked human genome within 4.1 hours with higher sensitivity than Bowtie/Bowtie2. FANSe2 thus provides robust accuracy, full indel sensitivity, fast speed, versatile compatibility and economical computational utilization, making it a useful and practical tool for deep sequencing applications. FANSe2 is freely available at http://bioinformatics.jnu.edu.cn/software/fanse2/.

  5. Comprehensive transcriptome assembly of Chickpea (Cicer arietinum L. using sanger and next generation sequencing platforms: development and applications.

    Directory of Open Access Journals (Sweden)

    Himabindu Kudapa

    Full Text Available A comprehensive transcriptome assembly of chickpea has been developed using 134.95 million Illumina single-end reads, 7.12 million single-end FLX/454 reads and 139,214 Sanger expressed sequence tags (ESTs from >17 genotypes. This hybrid transcriptome assembly, referred to as Cicer arietinumTranscriptome Assembly version 2 (CaTA v2, available at http://data.comparative-legumes.org/transcriptomes/cicar/lista_cicar-201201, comprising 46,369 transcript assembly contigs (TACs has an N50 length of 1,726 bp and a maximum contig size of 15,644 bp. Putative functions were determined for 32,869 (70.8% of the TACs and gene ontology assignments were determined for 21,471 (46.3%. The new transcriptome assembly was compared with the previously available chickpea transcriptome assemblies as well as to the chickpea genome. Comparative analysis of CaTA v2 against transcriptomes of three legumes - Medicago, soybean and common bean, resulted in 27,771 TACs common to all three legumes indicating strong conservation of genes across legumes. CaTA v2 was also used for identification of simple sequence repeats (SSRs and intron spanning regions (ISRs for developing molecular markers. ISRs were identified by aligning TACs to the Medicago genome, and their putative mapping positions at chromosomal level were identified using transcript map of chickpea. Primer pairs were designed for 4,990 ISRs, each representing a single contig for which predicted positions are inferred and distributed across eight linkage groups. A subset of randomly selected ISRs representing all eight chickpea linkage groups were validated on five chickpea genotypes and showed 20% polymorphism with average polymorphic information content (PIC of 0.27. In summary, the hybrid transcriptome assembly developed and novel markers identified can be used for a variety of applications such as gene discovery, marker-trait association, diversity analysis etc., to advance genetics research and breeding

  6. Next generation 9xx/10xx nm high power laser diode bars for multi-kilowatt industrial applications

    Science.gov (United States)

    Commin, Paul; Todt, René; Krejci, Martin; Bättig, Rainer; Brunner, Reinhard; Lichtenstein, Norbert

    2013-02-01

    We report on the development of high power, 9xx-10xx nm laser diode bars for use in direct diode systems and for solidstate and fibre laser pumping with applications in industrial markets. For 1 cm wide bars on micro channel cooler (MCC) we have achieved a reliable output power of 250 W across the 900 nm - 1060 nm range. At this output power level we have achieved power conversion efficiencies of 65-66 % and 90 % power content slow axis beam divergence of ~6.5°. Results of a 6400 h life test show an average power degradation of 0.6 % per 1000 h at this operating power level. We will also show results of high power bars assembled on the new OCLARO conductive cooler, the BLM. This new cooler has a small footprint of 12.6 mm × 24.8 mm and is designed for lateral or vertical stacking of diodes in multi kilowatt systems but with the benefits associated with a conductive cooler. The thermal properties are shown to be the same as for a standard CS mount. 1 cm wide high fill factor bars and 0.5 cm wide low fill factor half bars assembled on the BLM operate at 63-64 % power conversion efficiency (PCE) with output powers of up to 250 W and 150 W, respectively.

  7. Technical presentation: Next Generation Oscilloscopes

    CERN Multimedia

    PH Department

    2011-01-01

      Rohde & Schwarz "Next Generation Oscilloscopes" - Introduction and Presentation Agenda: Wednesday 23 March  -  09:30 to 11:30 (open end) Bldg. 13-2-005 Language: English 09.30 Presentation "Next Generation Oscilloscopes" from Rohde & Schwarz RTO / RTM in theory and practice Gerard Walker 10.15 Technical design details from R&D Dr. Markus Freidhof 10.45 Scope and Probe Roadmap (confidential) Guido Schulze 11.00 Open Discussion Feedback, first impression, wishes, needs and requirements from CERN All 11.30 Expert Talks, Hands on All Mr. Dr. Markus Freidhof, Head of R&D Oscilloscopes, Rohde & Schwarz, Germany; Mr. Guido Schulze, ...

  8. The Next Generation Science Standards

    Science.gov (United States)

    Pruitt, Stephen L.

    2015-01-01

    The Next Generation Science Standards (NGSS Lead States 2013) were released almost two years ago. Work tied to the NGSS, their adoption, and implementation continues to move forward around the country. Stephen L. Pruitt, senior vice president, science, at Achieve, an independent, nonpartisan, nonprofit education reform organization that was a lead…

  9. Next generation natriuretic peptide measurement

    DEFF Research Database (Denmark)

    Hunter, Ingrid; Goetze, Jens P

    2012-01-01

    in the molecular heterogeneity could in itself contain valuable information of clinical status, and the time seems right for industry and dedicated researchers in the field to get together and discuss the next generation natriuretic peptide measurement. In such an environment, new strategies can be developed...

  10. APPLICATION OF VISION METROLOGY TO IN-ORBIT MEASUREMENT OF LARGE REFLECTOR ONBOARD COMMUNICATION SATELLITE FOR NEXT GENERATION MOBILE SATELLITE COMMUNICATION

    Directory of Open Access Journals (Sweden)

    M. Akioka

    2016-06-01

    Full Text Available Satellite for next generation mobile satellite communication service with small personal terminal requires onboard antenna with very large aperture reflector larger than twenty meters diameter because small personal terminal with lower power consumption in ground base requires the large onboard reflector with high antenna gain. But, large deployable antenna will deform in orbit because the antenna is not a solid dish but the flexible structure with fine cable and mesh supported by truss. Deformation of reflector shape deteriorate the antenna performance and quality and stability of communication service. However, in case of digital beam forming antenna with phased array can modify the antenna beam performance due to adjustment of excitation amplitude and excitation phase. If we can measure the reflector shape precisely in orbit, beam pattern and antenna performance can be compensated with the updated excitation amplitude and excitation phase parameters optimized for the reflector shape measured every moment. Softbank Corporation and National Institute of Information and Communications Technology has started the project "R&D on dynamic beam control technique for next generation mobile communication satellite" as a contracted research project sponsored by Ministry of Internal Affairs and Communication of Japan. In this topic, one of the problem in vision metrology application is a strong constraints on geometry for camera arrangement on satellite bus with very limited space. On satellite in orbit, we cannot take many images from many different directions as ordinary vision metrology measurement and the available area for camera positioning is quite limited. Feasibility of vision metrology application and general methodology to apply to future mobile satellite communication satellite is to be found. Our approach is as follows: 1 Development of prototyping simulator to evaluate the expected precision for network design in zero order and first order

  11. Application of Vision Metrology to In-Orbit Measurement of Large Reflector Onboard Communication Satellite for Next Generation Mobile Satellite Communication

    Science.gov (United States)

    Akioka, M.; Orikasa, T.; Satoh, M.; Miura, A.; Tsuji, H.; Toyoshima, M.; Fujino, Y.

    2016-06-01

    Satellite for next generation mobile satellite communication service with small personal terminal requires onboard antenna with very large aperture reflector larger than twenty meters diameter because small personal terminal with lower power consumption in ground base requires the large onboard reflector with high antenna gain. But, large deployable antenna will deform in orbit because the antenna is not a solid dish but the flexible structure with fine cable and mesh supported by truss. Deformation of reflector shape deteriorate the antenna performance and quality and stability of communication service. However, in case of digital beam forming antenna with phased array can modify the antenna beam performance due to adjustment of excitation amplitude and excitation phase. If we can measure the reflector shape precisely in orbit, beam pattern and antenna performance can be compensated with the updated excitation amplitude and excitation phase parameters optimized for the reflector shape measured every moment. Softbank Corporation and National Institute of Information and Communications Technology has started the project "R&D on dynamic beam control technique for next generation mobile communication satellite" as a contracted research project sponsored by Ministry of Internal Affairs and Communication of Japan. In this topic, one of the problem in vision metrology application is a strong constraints on geometry for camera arrangement on satellite bus with very limited space. On satellite in orbit, we cannot take many images from many different directions as ordinary vision metrology measurement and the available area for camera positioning is quite limited. Feasibility of vision metrology application and general methodology to apply to future mobile satellite communication satellite is to be found. Our approach is as follows: 1) Development of prototyping simulator to evaluate the expected precision for network design in zero order and first order 2) Trial

  12. AG-NGS: a powerful and user-friendly computing application for the semi-automated preparation of next-generation sequencing libraries using open liquid handling platforms.

    Science.gov (United States)

    Callejas, Sergio; Álvarez, Rebeca; Benguria, Alberto; Dopazo, Ana

    2014-01-01

    Next-generation sequencing (NGS) is becoming one of the most widely used technologies in the field of genomics. Library preparation is one of the most critical, hands-on, and time-consuming steps in the NGS workflow. Each library must be prepared in an independent well, increasing the number of hours required for a sequencing run and the risk of human-introduced error. Automation of library preparation is the best option to avoid these problems. With this in mind, we have developed automatic genomics NGS (AG-NGS), a computing application that allows an open liquid handling platform to be transformed into a library preparation station without losing the potential of an open platform. Implementation of AG-NGS does not require programming experience, and the application has also been designed to minimize implementation costs. Automated library preparation with AG-NGS generated high-quality libraries from different samples, demonstrating its efficiency, and all quality control parameters fell within the range of optimal values.

  13. Next Generation of Photovoltaics New Concepts

    CERN Document Server

    Vega, Antonio; López, Antonio

    2012-01-01

    This book presents new concepts for a next generation of PV. Among these concepts are: Multijunction solar cells, multiple excitation solar cells (or how to take benefit of high energy photons for the creation of more than one electron hole-pair), intermediate band solar cells (or how to take advantage of below band-gap energy photons) and related technologies (for quantum dots, nitrides, thin films), advanced light management approaches (plasmonics). Written by world-class experts in next generation photovoltaics this book is an essential reference guide accessible to both beginners and experts working with solar cell technology. The book deeply analyzes the current state-of-the-art of the new photovoltaic approaches and outlines the implementation paths of these advanced devices. Topics addressed range from the fundamentals to the description of state-of-the-art of the new types of solar cells.

  14. Using next-generation sequencing to detect mutations endowing resistance to pesticides: application to acetolactate-synthase (ALS)-based resistance in barnyard grass, a polyploid grass weed.

    Science.gov (United States)

    Délye, Christophe; Causse, Romain; Gautier, Véronique; Poncet, Charles; Michel, Séverine

    2015-05-01

    Next-generation sequencing (NGS) technologies offer tremendous possibilities for accurate detection of mutations endowing pesticide resistance, yet their use for this purpose has not emerged in crop protection. This study aims at promoting NGS use for pesticide resistance diagnosis. It describes a simple procedure accessible to virtually any scientist and implementing freely accessible programs for the analysis of NGS data. Three PCR amplicons encompassing seven codons of the acetolactate-synthase gene crucial for herbicide resistance were sequenced using non-quantified pools of crude DNA extracts from 40 plants in each of 28 field populations of barnyard grass, a polyploid weed. A total of 63,959 quality NGS sequence runs were obtained using the 454 technology. Three herbicide-resistance-endowing mutations (Pro-197-Ser, Pro-197-Leu and/or Trp-574-Leu) were identified in seven populations. The NGS results were confirmed by individual plant Sanger sequencing. This work demonstrated the feasibility of NGS-based detection of pesticide resistance, and the advantages of NGS compared with other molecular biology techniques for analysing large numbers of individuals. NGS-based resistance diagnosis has the potential to play a substantial role in monitoring resistance, maintaining pesticide efficacy and optimising pesticide applications. © 2014 Society of Chemical Industry.

  15. Best practice guidelines for the use of next-generation sequencing applications in genome diagnostics: a national collaborative study of Dutch genome diagnostic laboratories.

    Science.gov (United States)

    Weiss, Marjan M; Van der Zwaag, Bert; Jongbloed, Jan D H; Vogel, Maartje J; Brüggenwirth, Hennie T; Lekanne Deprez, Ronald H; Mook, Olaf; Ruivenkamp, Claudia A L; van Slegtenhorst, Marjon A; van den Wijngaard, Arthur; Waisfisz, Quinten; Nelen, Marcel R; van der Stoep, Nienke

    2013-10-01

    Next-generation sequencing (NGS) methods are being adopted by genome diagnostics laboratories worldwide. However, implementing NGS-based tests according to diagnostic standards is a challenge for individual laboratories. To facilitate the implementation of NGS in Dutch laboratories, the Dutch Society for Clinical Genetic Laboratory Diagnostics (VKGL) set up a working group in 2012. The results of their discussions are presented here. We provide best practice guidelines and criteria for implementing and validating NGS applications in a clinical setting. We introduce the concept of "diagnostic yield" as the main performance characteristic for evaluating diagnostic tests. We recommend that the laboratory procedures, including the tested genes, should be recorded in a publicly available document describing the complete "diagnostic routing." We also propose that laboratories should use a list of "core disease genes" for specific genetic diseases. This core list contains the essential genes for each disease, and they should all be included in a diagnostic test to establish a reliable and accurate molecular diagnosis. The guidelines will ensure a clear and standardized quality of care provided by genetic diagnostic laboratories. The best practice guidelines and criteria that are presented here were adopted by the VKGL in January 2013. © 2013 WILEY PERIODICALS, INC.

  16. Towards Next Generation BI Systems

    DEFF Research Database (Denmark)

    Varga, Jovan; Romero, Oscar; Pedersen, Torben Bach

    2014-01-01

    Next generation Business Intelligence (BI) systems require integration of heterogeneous data sources and a strong user-centric orientation. Both needs entail machine-processable metadata to enable automation and allow end users to gain access to relevant data for their decision making processes....... Although evidently needed, there is no clear picture about the necessary metadata artifacts, especially considering user support requirements. Therefore, we propose a comprehensive metadata framework to support the user assistance activities and their automation in the context of next generation BI systems....... This framework is based on the findings of a survey of current user-centric approaches mainly focusing on query recommendation assistance. Finally, we discuss the benefits of the framework and present the plans for future work....

  17. Next Generation Biopharmaceuticals: Product Development.

    Science.gov (United States)

    Mathaes, Roman; Mahler, Hanns-Christian

    2018-04-11

    Therapeutic proteins show a rapid market growth. The relatively young biotech industry already represents 20 % of the total global pharma market. The biotech industry environment has traditionally been fast-pasted and intellectually stimulated. Nowadays the top ten best selling drugs are dominated by monoclonal antibodies (mABs).Despite mABs being the biggest medical breakthrough in the last 25 years, technical innovation does not stand still.The goal remains to preserve the benefits of a conventional mAB (serum half-life and specificity) whilst further improving efficacy and safety and to open new and better avenues for treating patients, e.g., improving the potency of molecules, target binding, tissue penetration, tailored pharmacokinetics, and reduced adverse effects or immunogenicity.The next generation of biopharmaceuticals can pose specific chemistry, manufacturing, and control (CMC) challenges. In contrast to conventional proteins, next-generation biopharmaceuticals often require lyophilization of the final drug product to ensure storage stability over shelf-life time. In addition, next-generation biopharmaceuticals require analytical methods that cover different ways of possible degradation patterns and pathways, and product development is a long way from being straight forward. The element of "prior knowledge" does not exist equally for most novel formats compared to antibodies, and thus the assessment of critical quality attributes (CQAs) and the definition of CQA assessment criteria and specifications is difficult, especially in early-stage development.

  18. Next Generation Energy. A study; Next Generation Energy. Studie

    Energy Technology Data Exchange (ETDEWEB)

    Reichert, Frank; Kitvarametha, Saman; Lehmann, Jochen; Ruhoff, Tim

    2010-07-01

    Under the short title 'Next Generation Energy', this publication discusses the complex problem of energy supply for the future. The authors attempt to identify the key issues that must be tackled, the business opportunities arising out of these issues, their practical feasibility and social impact. One of the findings of the study is the fact that consumers today are ready to buy electric-powered cars but there are not enough commercially available electric vehicles. The study is an attempt to tackle and advance this important and logistically complex issue. (orig.)

  19. Improving validation methods for molecular diagnostics: application of Bland-Altman, Deming and simple linear regression analyses in assay comparison and evaluation for next-generation sequencing.

    Science.gov (United States)

    Misyura, Maksym; Sukhai, Mahadeo A; Kulasignam, Vathany; Zhang, Tong; Kamel-Reid, Suzanne; Stockley, Tracy L

    2018-02-01

    A standard approach in test evaluation is to compare results of the assay in validation to results from previously validated methods. For quantitative molecular diagnostic assays, comparison of test values is often performed using simple linear regression and the coefficient of determination (R 2 ), using R 2 as the primary metric of assay agreement. However, the use of R 2 alone does not adequately quantify constant or proportional errors required for optimal test evaluation. More extensive statistical approaches, such as Bland-Altman and expanded interpretation of linear regression methods, can be used to more thoroughly compare data from quantitative molecular assays. We present the application of Bland-Altman and linear regression statistical methods to evaluate quantitative outputs from next-generation sequencing assays (NGS). NGS-derived data sets from assay validation experiments were used to demonstrate the utility of the statistical methods. Both Bland-Altman and linear regression were able to detect the presence and magnitude of constant and proportional error in quantitative values of NGS data. Deming linear regression was used in the context of assay comparison studies, while simple linear regression was used to analyse serial dilution data. Bland-Altman statistical approach was also adapted to quantify assay accuracy, including constant and proportional errors, and precision where theoretical and empirical values were known. The complementary application of the statistical methods described in this manuscript enables more extensive evaluation of performance characteristics of quantitative molecular assays, prior to implementation in the clinical molecular laboratory. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  20. Novel Transparent Phosphor Conversion Matrix with High Thermal Conductivity for Next Generation Phosphor-Converted LED-based Solid State Lighting

    Energy Technology Data Exchange (ETDEWEB)

    Bockstaller, Michael [Carnegie Mellon Univ., Pittsburgh, PA (United States)

    2017-02-06

    The low thermal conductivity of state-of-the-art polymer encapsulants (k ~ 0.15 Wm-1K-1) limits the efficiency and power density of current phosphor conversion light emitting diodes (pc-LEDs). The technical objective of this project was to demonstrate synthesis and processing schemes for the fabrication of polymer hybrid encapsulants with a thermal conductivity exceeding k = 0.4 Wm-1K-1 for LED applications. The ‘hybrid polymer’ approach encompasses the dispersion of high thermal conductivity particle fillers (zinc oxide, ZnO as well as the alpha-polymorph of alumina, Al2O3) within a polysiloxane matrix (poly(dimethylsiloxane), PDMS as well as poly(phenyl methyl siloxane), PPMS) to increase the thermal conductivity while maintaining optical transparency and photothermal stability at levels consistent with LED applications. To accomplish this goal, a novel synthesis method for the fabrication of nanosized ZnO particles was developed and a novel surface chemistry was established to modify the surface of zinc oxide particle fillers and thus to enable their dispersion in poly(dimethyl siloxane) (PDMS) matrix polymers. Molecular dynamics and Mie simulations were used to optimize ligand structure and to enable the concurrent mixing of particles in PDMS/PPMS embedding media while also minimizing the thermal boundary resistance as well as optical scattering of particle fillers. Using this approach the synthesis of PDMS/ZnO hybrid encapsulants exhibiting a thermal conductivity of 0.64 Wm-1K-1 and optical transparency > 0.7 mm-1 was demonstrated. A forming process based on micromolding was developed to demonstrate the forming of particle filled PDMS into film and lens shapes. Photothermal stability testing revealed stability of the materials for approximately 4000 min when exposed to blue light LED (450 nm, 30 W/cm2). One postgraduate and seven graduate students were supported by the project. The research performed within this project led to fifteen publications in peer

  1. Next-generation mid-infrared sources

    Science.gov (United States)

    Jung, D.; Bank, S.; Lee, M. L.; Wasserman, D.

    2017-12-01

    to provide a survey of the current state of the art for mid-IR sources, but instead looks primarily to provide a picture of potential next-generation optical and optoelectronic materials systems for mid-IR light generation.

  2. Demonstration of the First Real-Time End-to-End 40-Gb/s PAM-4 for Next-Generation Access Applications using 10-Gb/s Transmitter

    DEFF Research Database (Denmark)

    Wei, J. L.; Eiselt, Nicklas; Griesser, Helmut

    2016-01-01

    We demonstrate the first known experiment of a real-time end-to-end 40-Gb/s PAM-4 system for next-generation access applications using 10-Gb/s class transmitters only. Based on the measurement of a real-time 40-Gb/s PAM system, low-cost upstream and downstream link power budgets are estimated. Up...

  3. Next generation surveillance system (NGSS)

    International Nuclear Information System (INIS)

    Aparo, Massimo

    2006-01-01

    Development of 'functional requirements' for transparency systems may offer a near-term mode of regional cooperation. New requirements under development at the IAEA may provide a foundation for this potential activity. The Next Generation Surveillance System (NGSS) will become the new IAEA remote monitoring system Under new requirements the NGSS would attempt to use more commercial components to reduce cost, increase radiation survivability and further increase reliability. The NGSS must be available in two years due to rapidly approaching obsolescence in the existing DCM family. (author)

  4. Development of the Next Generation Air Quality Modeling System (20th Joint Conference on the Applications of Air Pollution Meteorology with the A&WMA)

    Science.gov (United States)

    A next generation air quality modeling system is being developed at the U.S. EPA to enable modeling of air quality from global to regional to (eventually) local scales. We envision that the system will have three configurations: 1. Global meteorology with seamless mesh refinemen...

  5. Best practice guidelines for the use of next-generation sequencing applications in genome diagnostics: a national collaborative study of dutch genome diagnostic laboratories

    NARCIS (Netherlands)

    Weiss, Marjan M.; van der Zwaag, Bert; Jongbloed, Jan D. H.; Vogel, Maartje J.; Brüggenwirth, Hennie T.; Lekanne Deprez, Ronald H.; Mook, Olaf; Ruivenkamp, Claudia A. L.; van Slegtenhorst, Marjon A.; van den Wijngaard, Arthur; Waisfisz, Quinten; Nelen, Marcel R.; van der Stoep, Nienke

    2013-01-01

    Next-generation sequencing (NGS) methods are being adopted by genome diagnostics laboratories worldwide. However, implementing NGS-based tests according to diagnostic standards is a challenge for individual laboratories. To facilitate the implementation of NGS in Dutch laboratories, the Dutch

  6. Next-Generation Tools For Next-Generation Surveys

    Science.gov (United States)

    Murray, S. G.

    2017-04-01

    The next generation of large-scale galaxy surveys, across the electromagnetic spectrum, loom on the horizon as explosively game-changing datasets, in terms of our understanding of cosmology and structure formation. We are on the brink of a torrent of data that is set to both confirm and constrain current theories to an unprecedented level, and potentially overturn many of our conceptions. One of the great challenges of this forthcoming deluge is to extract maximal scientific content from the vast array of raw data. This challenge requires not only well-understood and robust physical models, but a commensurate network of software implementations with which to efficiently apply them. The halo model, a semi-analytic treatment of cosmological spatial statistics down to nonlinear scales, provides an excellent mathematical framework for exploring the nature of dark matter. This thesis presents a next-generation toolkit based on the halo model formalism, intended to fulfil the requirements of next-generation surveys. Our toolkit comprises three tools: (i) hmf, a comprehensive and flexible calculator for halo mass functions (HMFs) within extended Press-Schechter theory, (ii) the MRP distribution for extremely efficient analytic characterisation of HMFs, and (iii) halomod, an extension of hmf which provides support for the full range of halo model components. In addition to the development and technical presentation of these tools, we apply each to the task of physical modelling. With hmf, we determine the precision of our knowledge of the HMF, due to uncertainty in our knowledge of the cosmological parameters, over the past decade of cosmic microwave background (CMB) experiments. We place rule-of-thumb uncertainties on the predicted HMF for the Planck cosmology, and find that current limits on the precision are driven by modeling uncertainties rather than those from cosmological parameters. With the MRP, we create and test a method for robustly fitting the HMF to observed

  7. Candu technology: the next generation now

    International Nuclear Information System (INIS)

    Hopwood, J.M.; Duffey, R.B.; Torgerson, D.F.

    2001-01-01

    We describe the development philosophy, direction and concepts that are being utilized by AECL to refine the CANDU reactor to meet the needs of current and future competitive energy markets. The technology development path for CANDU reactors is based on the optimization of the pressure tube concept. Because of the inherent modularity and flexibility of this basis for the core design, it is possible to provide a seamless and continuous evolution of the reactor design and performance. There is no need for a drastic shift in concept, in technology or in fuel. By continual refinement of the flow and materials conditions in the channels, the basic reactor can be thermally and operationally efficient, highly competitive and economic, and highly flexible in application. Thus, the design can build on the successful construction and operating experience of the existing plants, and no step changes in development direction are needed. This approach minimizes investor, operator and development risk but still provides technological, safety and performance advances. In today's world energy markets, major drivers for the technology development are: (a) reduced capital cost; (b) improved operation; (c) enhanced safety; and (d) fuel cycle flexibility. The drivers provide specific numerical targets. Meeting these drivers ensures that the concept meets and exceeds the customer economic, performance, safety and resource use goals and requirements, including the suitable national and international standards. This logical development of the CANDU concept leads naturally to the 'Next Generation' of CANDU reactors. The major features under development include an optimized lattice for SEU (slightly enriched uranium) fuel, light water cooling coupled with heavy water moderation, advanced fuel channels and CANFLEX fuel, optimization of plant performance, enhanced thermal and BOP (balance of plant) efficiency, and the adoption of layout and construction technology adapted from successful on

  8. Rhamnolipids--next generation surfactants?

    Science.gov (United States)

    Müller, Markus Michael; Kügler, Johannes H; Henkel, Marius; Gerlitzki, Melanie; Hörmann, Barbara; Pöhnlein, Martin; Syldatk, Christoph; Hausmann, Rudolf

    2012-12-31

    The demand for bio-based processes and materials in the petrochemical industry has significantly increased during the last decade because of the expected running out of petroleum. This trend can be ascribed to three main causes: (1) the increased use of renewable resources for chemical synthesis of already established product classes, (2) the replacement of chemical synthesis of already established product classes by new biotechnological processes based on renewable resources, and (3) the biotechnological production of new molecules with new features or better performances than already established comparable chemically synthesized products. All three approaches are currently being pursued for surfactant production. Biosurfactants are a very promising and interesting substance class because they are based on renewable resources, sustainable, and biologically degradable. Alkyl polyglycosides are chemically synthesized biosurfactants established on the surfactant market. The first microbiological biosurfactants on the market were sophorolipids. Of all currently known biosurfactants, rhamnolipids have the highest potential for becoming the next generation of biosurfactants introduced on the market. Although the metabolic pathways and genetic regulation of biosynthesis are known qualitatively, the quantitative understanding relevant for bioreactor cultivation is still missing. Additionally, high product titers have been exclusively described with vegetable oil as sole carbon source in combination with Pseudomonas aeruginosa strains. Competitive productivity is still out of reach for heterologous hosts or non-pathogenic natural producer strains. Thus, on the one hand there is a need to gain a deeper understanding of the regulation of rhamnolipid production on process and cellular level during bioreactor cultivations. On the other hand, there is a need for metabolizable renewable substrates, which do not compete with food and feed. A sustainable bioeconomy approach should

  9. The next generation CANDU 6

    International Nuclear Information System (INIS)

    Hopwood, J.M.

    1999-01-01

    AECL's product line of CANDU 6 and CANDU 9 nuclear power plants are adapted to respond to changing market conditions, experience feedback and technological development by a continuous improvement process of design evolution. The CANDU 6 Nuclear Power Plant design is a successful family of nuclear units, with the first four units entering service in 1983, and the most recent entering service this year. A further four CANDU 6 units are under construction. Starting in 1996, a focused forward-looking development program is under way at AECL to incorporate a series of individual improvements and integrate them into the CANDU 6, leading to the evolutionary development of the next-generation enhanced CANDU 6. The CANDU 6 improvements program includes all aspects of an NPP project, including engineering tools improvements, design for improved constructability, scheduling for faster, more streamlined commissioning, and improved operating performance. This enhanced CANDU 6 product will combine the benefits of design provenness (drawing on the more than 70 reactor-years experience of the seven operating CANDU 6 units), with the advantages of an evolutionary next-generation design. Features of the enhanced CANDU 6 design include: Advanced Human Machine Interface - built around the Advanced CANDU Control Centre; Advanced fuel design - using the newly demonstrated CANFLEX fuel bundle; Improved Efficiency based on improved utilization of waste heat; Streamlined System Design - including simplifications to improve performance and safety system reliability; Advanced Engineering Tools, -- featuring linked electronic databases from 3D CADDS, equipment specification and material management; Advanced Construction Techniques - based on open top equipment installation and the use of small skid mounted modules; Options defined for Passive Heat Sink capability and low-enrichment core optimization. (author)

  10. Thermonuclear ignition in the next generation tokamaks

    International Nuclear Information System (INIS)

    Johner, J.

    1989-04-01

    The extrapolation of experimental rules describing energy confinement and magnetohydrodynamic - stability limits, in known tokamaks, allow to show that stable thermonuclear ignition equilibria should exist in this configuration, if the product aB t x of the dimensions by a magnetic-field power is large enough. Quantitative application of this result to several next-generation tokamak projects show that those kinds of equilibria could exist in such devices, which would also have enough additional heating power to promote an effective accessible ignition

  11. Next Generation Geothermal Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Brugman, John; Hattar, Mai; Nichols, Kenneth; Esaki, Yuri

    1995-09-01

    A number of current and prospective power plant concepts were investigated to evaluate their potential to serve as the basis of the next generation geothermal power plant (NGGPP). The NGGPP has been envisaged as a power plant that would be more cost competitive (than current geothermal power plants) with fossil fuel power plants, would efficiently use resources and mitigate the risk of reservoir under-performance, and minimize or eliminate emission of pollutants and consumption of surface and ground water. Power plant concepts were analyzed using resource characteristics at ten different geothermal sites located in the western United States. Concepts were developed into viable power plant processes, capital costs were estimated and levelized busbar costs determined. Thus, the study results should be considered as useful indicators of the commercial viability of the various power plants concepts that were investigated. Broadly, the different power plant concepts that were analyzed in this study fall into the following categories: commercial binary and flash plants, advanced binary plants, advanced flash plants, flash/binary hybrid plants, and fossil/geothed hybrid plants. Commercial binary plants were evaluated using commercial isobutane as a working fluid; both air-cooling and water-cooling were considered. Advanced binary concepts included cycles using synchronous turbine-generators, cycles with metastable expansion, and cycles utilizing mixtures as working fluids. Dual flash steam plants were used as the model for the commercial flash cycle. The following advanced flash concepts were examined: dual flash with rotary separator turbine, dual flash with steam reheater, dual flash with hot water turbine, and subatmospheric flash. Both dual flash and binary cycles were combined with other cycles to develop a number of hybrid cycles: dual flash binary bottoming cycle, dual flash backpressure turbine binary cycle, dual flash gas turbine cycle, and binary gas turbine

  12. Next-generation Digital Earth.

    Science.gov (United States)

    Goodchild, Michael F; Guo, Huadong; Annoni, Alessandro; Bian, Ling; de Bie, Kees; Campbell, Frederick; Craglia, Max; Ehlers, Manfred; van Genderen, John; Jackson, Davina; Lewis, Anthony J; Pesaresi, Martino; Remetey-Fülöpp, Gábor; Simpson, Richard; Skidmore, Andrew; Wang, Changlin; Woodgate, Peter

    2012-07-10

    A speech of then-Vice President Al Gore in 1998 created a vision for a Digital Earth, and played a role in stimulating the development of a first generation of virtual globes, typified by Google Earth, that achieved many but not all the elements of this vision. The technical achievements of Google Earth, and the functionality of this first generation of virtual globes, are reviewed against the Gore vision. Meanwhile, developments in technology continue, the era of "big data" has arrived, the general public is more and more engaged with technology through citizen science and crowd-sourcing, and advances have been made in our scientific understanding of the Earth system. However, although Google Earth stimulated progress in communicating the results of science, there continue to be substantial barriers in the public's access to science. All these factors prompt a reexamination of the initial vision of Digital Earth, and a discussion of the major elements that should be part of a next generation.

  13. Application of next-generation sequencing for rapid marker development in molecular plant breeding: a case study on anthracnose disease resistance in Lupinus angustifolius L.

    Directory of Open Access Journals (Sweden)

    Yang Huaan

    2012-07-01

    Full Text Available Abstract Background In the last 30 years, a number of DNA fingerprinting methods such as RFLP, RAPD, AFLP, SSR, DArT, have been extensively used in marker development for molecular plant breeding. However, it remains a daunting task to identify highly polymorphic and closely linked molecular markers for a target trait for molecular marker-assisted selection. The next-generation sequencing (NGS technology is far more powerful than any existing generic DNA fingerprinting methods in generating DNA markers. In this study, we employed a grain legume crop Lupinus angustifolius (lupin as a test case, and examined the utility of an NGS-based method of RAD (restriction-site associated DNA sequencing as DNA fingerprinting for rapid, cost-effective marker development tagging a disease resistance gene for molecular breeding. Results Twenty informative plants from a cross of RxS (disease resistant x susceptible in lupin were subjected to RAD single-end sequencing by multiplex identifiers. The entire RAD sequencing products were resolved in two lanes of the 16-lanes per run sequencing platform Solexa HiSeq2000. A total of 185 million raw reads, approximately 17 Gb of sequencing data, were collected. Sequence comparison among the 20 test plants discovered 8207 SNP markers. Filtration of DNA sequencing data with marker identification parameters resulted in the discovery of 38 molecular markers linked to the disease resistance gene Lanr1. Five randomly selected markers were converted into cost-effective, simple PCR-based markers. Linkage analysis using marker genotyping data and disease resistance phenotyping data on a F8 population consisting of 186 individual plants confirmed that all these five markers were linked to the R gene. Two of these newly developed sequence-specific PCR markers, AnSeq3 and AnSeq4, flanked the target R gene at a genetic distance of 0.9 centiMorgan (cM, and are now replacing the markers previously developed by a traditional DNA

  14. Next-generation wireless technologies 4G and beyond

    CERN Document Server

    Chilamkurti, Naveen; Chaouchi, Hakima

    2013-01-01

    This comprehensive text/reference examines the various challenges to secure, efficient and cost-effective next-generation wireless networking. Topics and features: presents the latest advances, standards and technical challenges in a broad range of emerging wireless technologies; discusses cooperative and mesh networks, delay tolerant networks, and other next-generation networks such as LTE; examines real-world applications of vehicular communications, broadband wireless technologies, RFID technology, and energy-efficient wireless communications; introduces developments towards the 'Internet o

  15. LED lighting and the Next Generation of Greenhouse for Tomatoes. Proof of Principle; LED belichting en Het Nieuwe Telen bij tomaat. Proof of Principle

    Energy Technology Data Exchange (ETDEWEB)

    Dueck, T.; Janse, J.; Eveleens, B. [Wageningen UR Glastuinbouw, Wageningen (Netherlands); Nieboer, S.; Valstar, W.; Grootscholten, M. [GreenQ Improvement Centre, Bleiswijk (Netherlands)

    2012-08-15

    In this Proof of Principle project a tomato crop was grown under artificial lighting with the aim of 30% energy saving at the same level of production. Tomatoes (cultivar Komeett) were illuminated with 110 {mu}mol m{sup -2} s{sup -1} HPS (High Pressure Sodium) above the crop and 85 {mu}mol m{sup -2} s{sup -1} LED interlighting. The LEDs hung in 2 rows, approximately 40 cm above the lower leaves and the second strand at 40 or 70 cm above that. There were two types of LEDs used: production LEDs (light efficiency 1.6 {mu}mol m{sup -2} s{sup -1}, 87% red/13% blue) and inter-lighting LEDs (light efficiency 1.9 {mu}mol m{sup -2} s{sup -1}, 95% red/5% blue), with the same light intensity. At the start, the crop was given as much light as it could handle, and because the crop developed so well, the stem density was increased relatively early. This resulted in high fruit load, while insufficient light was available to compensate for the low levels of sunlight in the winter. In the 192 cm row spacing system the plants were too close to each other. Additional problems occurred with trace elements, lesser bumble bee activity, and a moist greenhouse climate which weakened the crop in the winter. Thus Botrytis occurred on the leaves and stems. The crop struggled with its recovery until early spring with more sunlight. Compared to a reference crop with 79 kg m{sup -2} tomatoes, 75 kg m{sup -2} were produced under-production LEDs, and 80 kg m{sup -2} under the interlighting LEDs, mainly because latter LEDs were used longer during the summer. 30% of the energy for dehumidification and heat energy, and 27% of the electricity was saved, relative to the reference crop. Thus it appears possible to save 30% energy with a near identical production [Dutch] In dit Proof of Principle project is een belichte tomatenteelt geteeld met als doel 30% energiebesparing bij een gelijke productie. Tomaten van het ras Komeett werden belicht met 110 {mu}mol m{sup -2} s{sup -1} SON-T belichting boven

  16. Competition for light and water increases tree carbon allocation to fine roots and leaves in a next-generation dynamic vegetation model

    Science.gov (United States)

    Lichstein, J. W.; Zhang, T.; Weng, E.; Farrior, C.; Dybzinski, R.; Birdsey, R.; Pacala, S. W.

    2015-12-01

    The response of the terrestrial carbon (C) cycle to climate change is a key uncertainty in land models. An important component of this uncertainty concerns plant functional diversity, which is typically represented in land models by ~10 functional types (PFTs) with fixed traits. However, few land models include the individual-level competitive mechanisms that largely determine how plant functional traits are distributed in time and space in real ecosystems. We have developed a new land model that represents height-structured competition for light with a simple canopy space-filling algorithm, the perfect plasticity approximation (PPA). The new land model, LM3-PPA, allows for an arbitrary number of PFTs (or 'species') whose spatial-temporal distributions are determined by the outcome of competition for light and water. We performed experiments with a modified version of LM3-PPA in 10 eastern U.S. grid cells and across simulated precipitation gradients to determine how competition for light and water affects tree C allocation to leaves, fine roots, and wood across climate gradients and in response to episodic drought. We studied the performance of 16 allocational types ('species') in monoculture and in competition with each other to determine the competitively-optimal, NPP-maximizing, and biomass-maximizing C allocation strategy under different environmental conditions. Under chronically moist conditions, competitively-optimal, NPP-maximizing, and biomass-maximizing trees all had similar C allocation. However, under chronically dry conditions, competitively-optimal trees allocated more C to both fine roots and leaves, and less C to wood, compared to NPP- or biomass-maximizing strategies. When subject to episodic drought, the most drought-tolerant allocational strategies had relatively low allocation to leaves (and thus low leaf area and low water demand). Thus, the "over-investment" in leaves that results from resource competition increases the vulnerability of

  17. NEXT GENERATION TURBINE SYSTEM STUDY

    Energy Technology Data Exchange (ETDEWEB)

    Frank Macri

    2002-02-28

    Rolls-Royce has completed a preliminary design and marketing study under a Department of Energy (DOE) cost shared contract (DE-AC26-00NT40852) to analyze the feasibility of developing a clean, high efficiency, and flexible Next Generation Turbine (NGT) system to meet the power generation market needs of the year 2007 and beyond. Rolls-Royce evaluated the full range of its most advanced commercial aerospace and aeroderivative engines alongside the special technologies necessary to achieve the aggressive efficiency, performance, emissions, economic, and flexibility targets desired by the DOE. Heavy emphasis was placed on evaluating the technical risks and the economic viability of various concept and technology options available. This was necessary to ensure the resulting advanced NGT system would provide extensive public benefits and significant customer benefits without introducing unacceptable levels of technical and operational risk that would impair the market acceptance of the resulting product. Two advanced cycle configurations were identified as offering significant advantages over current combined cycle products available in the market. In addition, balance of plant (BOP) technologies, as well as capabilities to improve the reliability, availability, and maintainability (RAM) of industrial gas turbine engines, have been identified. A customer focused survey and economic analysis of a proposed Rolls-Royce NGT product configuration was also accomplished as a part of this research study. The proposed Rolls-Royce NGT solution could offer customers clean, flexible power generation systems with very high efficiencies, similar to combined cycle plants, but at a much lower specific cost, similar to those of simple cycle plants.

  18. The next generation safeguards initiative

    International Nuclear Information System (INIS)

    Tobey, William

    2008-01-01

    NGSI or the Next Generation Safeguards Initiative is designed to revitalize the U.S. safeguards technical base, as well as invest in human resources, and to mobilize our primary asset - the U.S. National Laboratories - as well as industry and academia to restore capabilities. While NGSI is a U.S. effort it is intended to serve as a catalyst for a much broader commitment to international safeguards in partnership with the IAEA and other countries. Initiatives over the last years include such as the Proliferation Security Initiative, UN Security Council Resolution 1540, the Global Initiative to Combat Nuclear Terrorism, and initiatives of the G-8 and NSG to discourage the spread of enrichment and reprocessing. NGSI augments this agenda by providing a means to strengthen the technical and political underpinnings of IAEA safeguards. Priorities and envisioned activities under NGSI are the following. (1) Cooperation with IAEA and others to promote universal adoption of safeguards agreements and the Additional Protocol including greater information sharing between member states and the IAEA, investigation of weaponization and procurement activities, and options to strengthen the state-level approach to safeguards. (2) NGSI anticipates the deployment of new types of reactors and fuel cycle facilities, as well as the need to use limited safeguards resources effectively and efficiently, especially in plants that pose the largest burden specifically complex, bulk-handling facilities. (3) NGSI will encourage a generational improvement in current safeguards technologies including improvement of precision and speed of nuclear measurements, performance of real-time process monitoring and surveillance in unattended mode, enabling in-field, pre-screening and analysis of nuclear and environmental samples, and collection, integration, analysis and archiving safeguards-relevant information from all available sources.(4) NGSI will address human capital management. Training and

  19. Translational Health: The Next Generation of Medicine

    National Research Council Canada - National Science Library

    Mural, Richard J

    2006-01-01

    The "Translational Health - the Next Generation of Medicine" conference brought together scientists and medical professionals from across the country and Europe to present and discuss their research...

  20. Terahertz planar antennas for next generation communication

    CERN Document Server

    Jha, Kumud Ranjan

    2014-01-01

    This book describes various methods to enhance the directivity of  planar antennas, enabling the next generation of high frequency, wireless communication.  The authors discuss various applications to the terahertz regime of the electromagnetic spectrum, with an emphasis on gain enhancement mechanisms.  The numerical models of these antennas are presented and the analytical results are supported, using commercial simulators. The multilayer substrate microstrip transmission line at terahertz frequency is also explored and a method to obtain the various parameters of this interconnect at high frequency is described.  This book will be a valuable resource for anyone needing to explore the terahertz band gap for future wireless communication, in an effort to solve the bandwidth (spectrum scarcity) problem. • Enables development of terahertz communication systems in a license-free band of the electromagnetic spectrum; • Describes methods to design a multi-layered substrate transmission line to reduce var...

  1. Statistical analysis of next generation sequencing data

    CERN Document Server

    Nettleton, Dan

    2014-01-01

    Next Generation Sequencing (NGS) is the latest high throughput technology to revolutionize genomic research. NGS generates massive genomic datasets that play a key role in the big data phenomenon that surrounds us today. To extract signals from high-dimensional NGS data and make valid statistical inferences and predictions, novel data analytic and statistical techniques are needed. This book contains 20 chapters written by prominent statisticians working with NGS data. The topics range from basic preprocessing and analysis with NGS data to more complex genomic applications such as copy number variation and isoform expression detection. Research statisticians who want to learn about this growing and exciting area will find this book useful. In addition, many chapters from this book could be included in graduate-level classes in statistical bioinformatics for training future biostatisticians who will be expected to deal with genomic data in basic biomedical research, genomic clinical trials and personalized med...

  2. Analysis of Low Dimensional Nanoscaled Inversion-Mode InGaAs MOSFETs for Next-Generation Electrical and Photonic Applications

    Directory of Open Access Journals (Sweden)

    C. H. Yu

    2015-01-01

    Full Text Available The electrical characteristics of In0.53Ga0.47As MOSFET grown with Si interface passivation layer (IPL and high k gate oxide HfO2 layer have been investigated in detail. The influences of Si IPL thickness, gate oxide HfO2 thickness, the doping depth, and concentration of source and drain layer on output and transfer characteristics of the MOSFET at fixed gate or drain voltages have been individually simulated and analyzed. The determination of the above parameters is suggested based on their effect on maximum drain current, leakage current, saturated voltage, and so forth. It is found that the channel length decreases with the increase of the maximum drain current and leakage current simultaneously. Short channel effects start to appear when the channel length is less than 0.9 μm and experience sudden sharp increases which make device performance degrade and reach their operating limits when the channel length is further lessened down to 0.5 μm. The results demonstrate the usefulness of short channel simulations for designs and optimization of next-generation electrical and photonic devices.

  3. The DOE Next-Generation Drivetrain for Wind Turbine Applications: Gearbox, Generator, and Advanced Si/SiC Hybrid Inverter System: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Erdman, William; Keller, Jonathan

    2016-08-01

    This paper reports on the design and testing results from the U.S. Department of Energy Next-Generation Wind Turbine Drivetrain Project. The drivetrain design reduces the cost of energy by increasing energy capture through drivetrain efficiency improvements; by reducing operation and maintenance costs through reducing gearbox failures; and by lowering capital costs through weight reduction and a series of mechanical and electronic innovations. The paper provides an overview of the drivetrain gearbox and generator and provides a deeper look into the power converter system. The power converter has a number of innovations including the use of hybrid silicon (Si)/silicon carbide (SiC) isolated baseplate switching modules. Switching energies are compared between SiC and Si PIN diodes. The efficiency improvement by use of the SiC diode in a three-level converter is also described. Finally, a brief discussion covering utility interconnect requirements for turbines is provided with a particular focus on utility events that lead to high transient torque loads on drivetrain mechanical elements.

  4. Development of ten microsatellite markers from the keystone mistletoe Tristerix corymbosus (Loranthaceae) using 454 next generation sequencing and their applicability to population genetic structure studies.

    Science.gov (United States)

    Fontúrbel, Francisco E; Murúa, Maureen M; Vega-Retter, Caren

    2016-05-01

    Tristerix corymbosus (Loranthaceae) is a keystone mistletoe from the South American temperate rainforests. As most mistletoes, T. corymbosus relies on biotic pollination and seed dispersal, which may cause population structure. For a better understanding of its ecology, we isolated and characterized ten polymorphic microsatellite loci for this species. We used 454 Next Generation Sequencing to build a microsatellite library from a high quality DNA sample. We tested 90 sequences from which we obtained ten polymorphic markers. In order to assess their variability, the novel markers were tested in 48 individuals from three locations of the Valdivian Coastal Reserve in Chile. We also estimated genetic differences between pairs of populations using the FST statistic. The mean number of alleles per locus in the 48 individuals studied was 7.1 (2-17 alleles per locus). The observed and expected heterozygosity ranged from 0.298 to 0.634 and from 0.310 to 0.881, respectively. There were genetic differences among the three populations assessed, according to the FST values (ranging from 0.048 to 0.100, all significant) and, the number of alleles per locus ranged from 3.9 to 5.1. These are the first microsatellite markers developed for T. corymbosus, and they arise as a powerful tool for studying population structure, genetic diversity and gene flow at the landscape scale, along its distribution.

  5. A Review of LOX/Kerosene Combustion Instability in American and Russian Combustion Devices in Application to Next-Generation Launch Technology

    Science.gov (United States)

    Rocker, Marvin; Nesman, Tomas E.; Hulka, James R.; Dougherty, N. Sam

    2003-01-01

    The Next-Generation Launch Technology (NGLT) project was introduced with its objectives. To meet the objectives, NASA has directed aerospace industry to perform advances and risk reduction of relevant technologies, including propulsion. Originally, the propulsion industry focused on producing both LOWLH2 and LOWkerosene flight engine technology demonstrators. These flight engine technology demonstrators were briefly reviewed. NASA recently redirected this focus to Lowkerosene only. Discussion of LOWkerosene combustion devices was and is prefaced by grave concerns about combustion instability. These concerns have prompted a review of LOWkerosene combustion instability in American and Russian combustion devices. In the review of the Russian propulsion industry's experience in eliminating LOWkerosene combustion instabilities, the history of principal Russian rocket scientists and their role in the development of LOXkerosene combustion devices is presented. The innovative methods implemented by the Russians of eliminations combustion instabilities in LOXkerosene combustion devices were reviewed. The successful elimination of these combustion instabilities has resulted in two generations of Russian-produced, high-performance LOWkerosene combustion devices.

  6. Next Generation Suspension Dynamics Algorithms

    Energy Technology Data Exchange (ETDEWEB)

    Schunk, Peter Randall [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Higdon, Jonathon [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Chen, Steven [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2014-12-01

    This research project has the objective to extend the range of application, improve the efficiency and conduct simulations with the Fast Lubrication Dynamics (FLD) algorithm for concentrated particle suspensions in a Newtonian fluid solvent. The research involves a combination of mathematical development, new computational algorithms, and application to processing flows of relevance in materials processing. The mathematical developments clarify the underlying theory, facilitate verification against classic monographs in the field and provide the framework for a novel parallel implementation optimized for an OpenMP shared memory environment. The project considered application to consolidation flows of major interest in high throughput materials processing and identified hitherto unforeseen challenges in the use of FLD in these applications. Extensions to the algorithm have been developed to improve its accuracy in these applications.

  7. Next Generation Software Process Improvement

    National Research Council Canada - National Science Library

    Turnas, Daniel

    2003-01-01

    .... The application of these processes allows for an organization to mature. The software maturity level, and process improvement, of an organization can be measured with the Capability Maturity Model...

  8. Next generation CANDU heat transport system parameter assessment

    International Nuclear Information System (INIS)

    Hau, K.F.; Love, J.W.; Vadera, M.; Vecchiarelli, J.

    2001-01-01

    AECL has initiated an innovative program to develop the next generation of technologies for CANDU reactors, and to apply them to a highly cost-effective new family of next generation power plants. Four major design changes were considered in the present conceptual design of the Heat Transport System (HTS) for the Next Generation (NG) CANDU. These include: light water replacement of heavy water as coolant, a compact core design resulting from a fuel channel lattice pitch reduction, use of Slightly Enriched Uranium (SEU) CANFLEX fuel bundles, and higher HTS and Turbine Generator (TG) operating pressures and temperatures. In designing the HTS, the goal is to reduce the capital cost while meeting the design and safety requirements with robust safety margins. This paper describes the studies to optimize key HTS parameters, including the assessment methodology and the basis of proposed design conditions for the NG CANDU HTS. (author)

  9. Development and application of a next-generation-sequencing (NGS approach to detect known and novel gene defects underlying retinal diseases

    Directory of Open Access Journals (Sweden)

    Audo Isabelle

    2012-01-01

    Full Text Available Abstract Background Inherited retinal disorders are clinically and genetically heterogeneous with more than 150 gene defects accounting for the diversity of disease phenotypes. So far, mutation detection was mainly performed by APEX technology and direct Sanger sequencing of known genes. However, these methods are time consuming, expensive and unable to provide a result if the patient carries a new gene mutation. In addition, multiplicity of phenotypes associated with the same gene defect may be overlooked. Methods To overcome these challenges, we designed an exon sequencing array to target 254 known and candidate genes using Agilent capture. Subsequently, 20 DNA samples from 17 different families, including four patients with known mutations were sequenced using Illumina Genome Analyzer IIx next-generation-sequencing (NGS platform. Different filtering approaches were applied to identify the genetic defect. The most likely disease causing variants were analyzed by Sanger sequencing. Co-segregation and sequencing analysis of control samples validated the pathogenicity of the observed variants. Results The phenotype of the patients included retinitis pigmentosa, congenital stationary night blindness, Best disease, early-onset cone dystrophy and Stargardt disease. In three of four control samples with known genotypes NGS detected the expected mutations. Three known and five novel mutations were identified in NR2E3, PRPF3, EYS, PRPF8, CRB1, TRPM1 and CACNA1F. One of the control samples with a known genotype belongs to a family with two clinical phenotypes (Best and CSNB, where a novel mutation was identified for CSNB. In six families the disease associated mutations were not found, indicating that novel gene defects remain to be identified. Conclusions In summary, this unbiased and time-efficient NGS approach allowed mutation detection in 75% of control cases and in 57% of test cases. Furthermore, it has the possibility of associating known gene

  10. Validation and Application of a Custom-Designed Targeted Next-Generation Sequencing Panel for the Diagnostic Mutational Profiling of Solid Tumors.

    Directory of Open Access Journals (Sweden)

    Guy Froyen

    Full Text Available The inevitable switch from standard molecular methods to next-generation sequencing for the molecular profiling of tumors is challenging for most diagnostic laboratories. However, fixed validation criteria for diagnostic accreditation are not in place because of the great variability in methods and aims. Here, we describe the validation of a custom panel of hotspots in 24 genes for the detection of somatic mutations in non-small cell lung carcinoma, colorectal carcinoma and malignant melanoma starting from FFPE sections, using 14, 36 and 5 cases, respectively. The targeted hotspots were selected for their present or future clinical relevance in solid tumor types. The target regions were enriched with the TruSeq approach starting from limited amounts of DNA. Cost effective sequencing of 12 pooled libraries was done using a micro flow cell on the MiSeq and subsequent data analysis with MiSeqReporter and VariantStudio. The entire workflow was diagnostically validated showing a robust performance with maximal sensitivity and specificity using as thresholds a variant allele frequency >5% and a minimal amplicon coverage of 300. We implemented this method through the analysis of 150 routine diagnostic samples and identified clinically relevant mutations in 16 genes including KRAS (32%, TP53 (32%, BRAF (12%, APC (11%, EGFR (8% and NRAS (5%. Importantly, the highest success rate was obtained when using also the low quality DNA samples. In conclusion, we provide a workflow for the validation of targeted NGS by a custom-designed pan-solid tumor panel in a molecular diagnostic lab and demonstrate its robustness in a clinical setting.

  11. Application of a multi-gene next-generation sequencing panel to a non-invasive oesophageal cell-sampling device to diagnose dysplastic Barrett's oesophagus.

    Science.gov (United States)

    Katz-Summercorn, Annalise; Anand, Shubha; Ingledew, Sophie; Huang, Yuanxue; Roberts, Thomas; Galeano-Dalmau, Nuria; O'Donovan, Maria; Liu, Hongxiang; Fitzgerald, Rebecca C

    2017-10-01

    The early detection and endoscopic treatment of patients with the dysplastic stage of Barrett's oesophagus is a key to preventing progression to oesophageal adenocarcinoma. However, endoscopic surveillance protocols are hampered by the invasiveness of repeat endoscopy, sampling bias, and a subjective histopathological diagnosis of dysplasia. In this case-control study, we investigated the use of a non-invasive, pan-oesophageal cell-sampling device, the Cytosponge™, coupled with a cancer hot-spot panel to identify patients with dysplastic Barrett's oesophagus. Formalin-fixed, paraffin-embedded (FFPE) Cytosponge™ samples from 31 patients with non-dysplastic and 28 with dysplastic Barrett's oesophagus with good available clinical annotation were selected for inclusion. Samples were microdissected and amplicon sequencing performed using a panel covering > 2800 COSMIC hot-spot mutations in 50 oncogenes and tumour suppressor genes . S trict mutation criteria were determined and duplicates were run to confirm any mutations with an allele frequency panel achieved a 71.4% sensitivity (95% CI 51.3-86.8) and 90.3% (95% CI 74.3-98.0) specificity for diagnosing dysplasia. TP53 had the highest rate of mutation in 14/28 dysplastic samples (50%). CDKN2A was mutated in 6/28 (21.4%), ERBB2 in 3/28 (10.7%), and 5 other genes at lower frequency. The only gene from this panel found to be mutated in the non-dysplastic cases was CDKN2A in 3/31 cases (9.7%) in keeping with its known loss early in the natural history of the disease. Hence, it is possible to apply a multi-gene cancer hot-spot panel and next-generation sequencing to microdissected, FFPE samples collected by the Cytosponge™, in order to distinguish non-dysplastic from dysplastic Barrett's oesophagus. Further work is required to maximize the panel sensitivity.

  12. Genetic richness and diversity in Cryptosporidium hominis and C. parvum reveals major knowledge gaps and a need for the application of "next generation" technologies--research review.

    Science.gov (United States)

    Jex, Aaron R; Gasser, Robin B

    2010-01-01

    Cryptosporidium species (apicomplexan protists) are a major cause of diarrhoeal disease (= cryptosporidiosis) in humans worldwide. The impact of cryptosporidiosis is also compounded by the spread of HIV/AIDS and a lack of cost-effective anti-cryptosporidial chemotherapeutics or vaccines. Mitigation of the impact of cryptosporidiosis in humans needs to focus on prevention and control strategies, built on a sound understanding of the epidemiology of Cryptosporidium species. Refined epidemiological studies rely on the use of molecular tools employing informative genetic markers. Currently, the 60-kDa glycoprotein gene (gp60) is the most suitable and widely used genetic marker for Cryptosporidium species infecting humans. Here, we undertake an analysis of all publicly-available gp60 sequence data and associated literature for C. hominis and C. parvum, and yield useful insights into the richness, diversity and distribution of genetic variants, and link these variants to human cryptosporidiosis. This global analysis reveals that, despite high genetic richness in Cryptosporidium isolates from humans, there is a surprisingly low diversity. It also highlights limited knowledge about the genetics of cryptosporidiosis in developing nations and in many animals that might act as infection sources. Clearly, there is a major need for more comprehensive studies of Cryptosporidium infecting humans and other animals in Africa and Asia. As molecular technologies improve and become affordable, future studies should utilize "next generation" sequencing and bioinformatic platforms to conduct comparative 'genome sequence surveys' to test the validity of current genetic classifications based on gp60 data. Complemented by in vitro and in vivo investigations, these biotechnological advances will also assist significantly in the search for new intervention strategies against human cryptosporidiosis.

  13. Next Generation Reactors in Korea

    International Nuclear Information System (INIS)

    Oh, Yongshick; Choi, Youngsang; Park, Keecheol

    1990-01-01

    In Korea, nuclear power will be continuously needed to meet the trend of steady increase in electricity demand. But in relation to the further development of nuclear energy, there are still many uncertainties to be solved such as power demand forecast, site availability, thermal energy utilization and technology enhancement for economic and safety. To cope with those uncertainties effectively and to proceed the nuclear projects uninterruptedly, KEPCO decided to initiate two research project. i. e., one is 'the outlook and developmental strategy of nuclear energy for the early 21st century in the R. O. K' and the other is 'the feasibility study on the advanced reactors in Korea. Prospects of nuclear energy in Korea was overviewed and recommendations from the industry were introduced. It is strong opinion of Korea nuclear industry that nuclear policy should be changed from the support policy to the target management policy. In the point of reactor strategy, the life of light water reactor technology might be longer than expected before in Korea and it is emphasized that good maintenance of light water reactor technology and smooth transition program to the advanced technologies should be carefully considered. There are differences in the opinions between preferences to the evolutionary and/or passive, inherently safe reactors but, in the long-term point of view, it is judged to be desirable to have alternatives

  14. Efficient Cryptography for the Next Generation Secure Cloud

    Science.gov (United States)

    Kupcu, Alptekin

    2010-01-01

    Peer-to-peer (P2P) systems, and client-server type storage and computation outsourcing constitute some of the major applications that the next generation cloud schemes will address. Since these applications are just emerging, it is the perfect time to design them with security and privacy in mind. Furthermore, considering the high-churn…

  15. Development of Next-Generation Borehole Magnetometer and Its Potential Application in Constraining the Magnetic Declination of Oman Samail Ophiolite at ICDP Drill Sites

    Science.gov (United States)

    Lee, S. M.; Parq, J. H.; Kim, H.; Moe, K.; Lee, C. S.; Kanamatsu, T.; Kim, K. J.; Bahk, K. S.

    2017-12-01

    Determining the azimuthal orientation of core samples obtained from deep drilling is extremely difficult because the core itself could have rotated during drilling operations. Several indirect methods have been devised to address this issue, but have certain limitations. Thus it is still a challenge to determine the azimuthal orientation consistently over the entire length of the hole. Provided that the recovery rate is high and thus all the other magnetic properties such as magnetization intensity and inclination are measured from the recovered cores, one possible method for ascertaining magnetic declination information is to measure the magnetic field inside the empty borehole and invert for the best fitting declination. However, there are two major problems: one is that present-day borehole magnetometers are not precise enough to resolve changes in direction of magnetization, and the other is that in most rock drilling experiments the rate of recovery is low. To overcome the first major problem which is technical, scientists from Korea and Japan jointly conducted the development for the next-generation borehole magnetometer, namely 3GBM (3rd Generation Borehole Magnetometer). The borehole magnetometer which uses fiber-optic laser gyro promises to provide accurate information on not only the magnetic field itself but also the orientation of the instrument inside the borehole. Our goal is to deploy this borehole magnetometer in the ICDP Oman Drilling Project Phase 2 drilling experiment early 2018. The site may be suitable for the investigation because, as recent Phase 1 of the Oman Samail Ophiolite drilling has demonstrated, the recovery rate was very high. Also the post-drilling measurements onboard DV Chikyu have shown that much of the recovered samples has moderate magnetization intensity on the order of 0.1 and 1 A/m. Here, we present the results of numerical simulation of magnetic field inside the borehole using finite element method to show that magnetic

  16. Next generation DNA led technologies

    CERN Document Server

    Jyothsna, G; Kashyap, Amita

    2016-01-01

    This brief highlights advances in DNA technologies and their wider applications. DNA is the source of life and has been studied since a generation, but very little is known as yet. Several sophisticated technologies of the current era have laid their foundations on the principle of DNA based mechanisms. DNA based technologies are bringing a new revolution of Advanced Science and Technology. Forensic Investigation, Medical Diagnosis, Paternity Disputes, Individual Identity, Health insurance, Motor Insurance have incorporated the DNA testing and profiling technologies for settling the issues.

  17. Galaxy LIMS for next-generation sequencing

    NARCIS (Netherlands)

    Scholtalbers, J.; Rossler, J.; Sorn, P.; Graaf, J. de; Boisguerin, V.; Castle, J.; Sahin, U.

    2013-01-01

    SUMMARY: We have developed a laboratory information management system (LIMS) for a next-generation sequencing (NGS) laboratory within the existing Galaxy platform. The system provides lab technicians standard and customizable sample information forms, barcoded submission forms, tracking of input

  18. NOAA NEXt-Generation RADar (NEXRAD) Products

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset consists of Level III weather radar products collected from Next-Generation Radar (NEXRAD) stations located in the contiguous United States, Alaska,...

  19. The Next Generation Transit Survey (NGTS)

    Science.gov (United States)

    Wheatley, Peter J.; West, Richard G.; Goad, Michael R.; Jenkins, James S.; Pollacco, Don L.; Queloz, Didier; Rauer, Heike; Udry, Stéphane; Watson, Christopher A.; Chazelas, Bruno; Eigmüller, Philipp; Lambert, Gregory; Genolet, Ludovic; McCormac, James; Walker, Simon; Armstrong, David J.; Bayliss, Daniel; Bento, Joao; Bouchy, François; Burleigh, Matthew R.; Cabrera, Juan; Casewell, Sarah L.; Chaushev, Alexander; Chote, Paul; Csizmadia, Szilárd; Erikson, Anders; Faedi, Francesca; Foxell, Emma; Gänsicke, Boris T.; Gillen, Edward; Grange, Andrew; Günther, Maximilian N.; Hodgkin, Simon T.; Jackman, James; Jordán, Andrés; Louden, Tom; Metrailler, Lionel; Moyano, Maximiliano; Nielsen, Louise D.; Osborn, Hugh P.; Poppenhaeger, Katja; Raddi, Roberto; Raynard, Liam; Smith, Alexis M. S.; Soto, Maritza; Titz-Weider, Ruth

    2018-04-01

    We describe the Next Generation Transit Survey (NGTS), which is a ground-based project searching for transiting exoplanets orbiting bright stars. NGTS builds on the legacy of previous surveys, most notably WASP, and is designed to achieve higher photometric precision and hence find smaller planets than have previously been detected from the ground. It also operates in red light, maximizing sensitivity to late K and early M dwarf stars. The survey specifications call for photometric precision of 0.1 per cent in red light over an instantaneous field of view of 100 deg2, enabling the detection of Neptune-sized exoplanets around Sun-like stars and super-Earths around M dwarfs. The survey is carried out with a purpose-built facility at Cerro Paranal, Chile, which is the premier site of the European Southern Observatory (ESO). An array of twelve 20 cm f/2.8 telescopes fitted with back-illuminated deep-depletion CCD cameras is used to survey fields intensively at intermediate Galactic latitudes. The instrument is also ideally suited to ground-based photometric follow-up of exoplanet candidates from space telescopes such as TESS, Gaia and PLATO. We present observations that combine precise autoguiding and the superb observing conditions at Paranal to provide routine photometric precision of 0.1 per cent in 1 h for stars with I-band magnitudes brighter than 13. We describe the instrument and data analysis methods as well as the status of the survey, which achieved first light in 2015 and began full-survey operations in 2016. NGTS data will be made publicly available through the ESO archive.

  20. Next Generation BioPhotonics Workstation

    DEFF Research Database (Denmark)

    Glückstad, Jesper

    2010-01-01

    We are developing a Next Generation BioPhotonics Workstation to be applied in research on regulated microbial cell growth including their underlying physiological mechanisms, in vivo characterization of cell constituents and manufacturing of nanostructures and meta-materials.......We are developing a Next Generation BioPhotonics Workstation to be applied in research on regulated microbial cell growth including their underlying physiological mechanisms, in vivo characterization of cell constituents and manufacturing of nanostructures and meta-materials....

  1. A Next Generation BioPhotonics Workstation

    DEFF Research Database (Denmark)

    Glückstad, Jesper; Palima, Darwin; Tauro, Sandeep

    2011-01-01

    We are developing a Next Generation BioPhotonics Workstation to be applied in research on regulated microbial cell growth including their underlying physiological mechanisms, in vivo characterization of cell constituents and manufacturing of nanostructures and meta-materials.......We are developing a Next Generation BioPhotonics Workstation to be applied in research on regulated microbial cell growth including their underlying physiological mechanisms, in vivo characterization of cell constituents and manufacturing of nanostructures and meta-materials....

  2. Optical Subsystems for Next Generation Access Networks

    DEFF Research Database (Denmark)

    Lazaro, J.A; Polo, V.; Schrenk, B.

    2011-01-01

    Recent optical technologies are providing higher flexibility to next generation access networks: on the one hand, providing progressive FTTx and specifically FTTH deployment, progressively shortening the copper access network; on the other hand, also opening fixed-mobile convergence solutions...... in next generation PON architectures. It is provided an overview of the optical subsystems developed for the implementation of the proposed NG-Access Networks....

  3. Next generation spin torque memories

    CERN Document Server

    Kaushik, Brajesh Kumar; Kulkarni, Anant Aravind; Prajapati, Sanjay

    2017-01-01

    This book offers detailed insights into spin transfer torque (STT) based devices, circuits and memories. Starting with the basic concepts and device physics, it then addresses advanced STT applications and discusses the outlook for this cutting-edge technology. It also describes the architectures, performance parameters, fabrication, and the prospects of STT based devices. Further, moving from the device to the system perspective it presents a non-volatile computing architecture composed of STT based magneto-resistive and all-spin logic devices and demonstrates that efficient STT based magneto-resistive and all-spin logic devices can turn the dream of instant on/off non-volatile computing into reality.

  4. Modelling with stakeholders - Next generation

    Science.gov (United States)

    Voinov, Alexey; Kolagani, Nagesh; McCall, Michael K; Glynn, Pierre D.; Kragt, Marit E; Ostermann, Frank O; Pierce, Suzanne A; Ramu, Palaniappan

    2016-01-01

    This paper updates and builds on ‘Modelling with Stakeholders’ Voinov and Bousquet, 2010 which demonstrated the importance of, and demand for, stakeholder participation in resource and environmental modelling. This position paper returns to the concepts of that publication and reviews the progress made since 2010. A new development is the wide introduction and acceptance of social media and web applications, which dramatically changes the context and scale of stakeholder interactions and participation. Technology advances make it easier to incorporate information in interactive formats via visualization and games to augment participatory experiences. Citizens as stakeholders are increasingly demanding to be engaged in planning decisions that affect them and their communities, at scales from local to global. How people interact with and access models and data is rapidly evolving. In turn, this requires changes in how models are built, packaged, and disseminated: citizens are less in awe of experts and external authorities, and they are increasingly aware of their own capabilities to provide inputs to planning processes, including models. The continued acceleration of environmental degradation and natural resource depletion accompanies these societal changes, even as there is a growing acceptance of the need to transition to alternative, possibly very different, life styles. Substantive transitions cannot occur without significant changes in human behaviour and perceptions. The important and diverse roles that models can play in guiding human behaviour, and in disseminating and increasing societal knowledge, are a feature of stakeholder processes today.

  5. Next Generation Sequencing of Tubal Intraepithelial Carcinomas

    Science.gov (United States)

    McDaniel, Andrew S.; Stall, Jennifer N.; Hovelson, Daniel H.; Cani, Andi K.; Liu, Chia-Jen; Tomlins, Scott A.; Cho, Kathleen R.

    2016-01-01

    Importance High-grade serous carcinoma (HGSC) is the most prevalent and lethal form of ovarian cancer. HGSCs frequently arise in the distal fallopian tubes rather than the ovary, developing from small precursor lesions called serous tubal intraepithelial carcinomas (TICs or more specifically STICs). While STICs have been reported to harbor TP53 mutations, detailed molecular characterizations of these lesions are lacking. Observations We performed targeted next generation sequencing (NGS) on formalin-fixed, paraffin- embedded tissue from four women, two with HGSC and two with uterine endometrioid carcinoma (UEC) who were diagnosed with synchronous STICs. We detected concordant mutations in both HGSCs with synchronous STICs, including TP53 mutations as well as assumed germline BRCA1/2 alterations, confirming a clonal relationship between these lesions. NGS confirmed the presence of a STIC clonally unrelated to one case of UEC. NGS of the other tubal lesion diagnosed as a STIC unexpectedly supported the lesion as a micrometastasis from the associated UEC. Conclusions and Relevance We demonstrate that targeted NGS can identify genetic lesions in minute lesions such as TICs, and confirm TP53 mutations as early driving events for HGSC. NGS also demonstrated unexpected relationships between presumed STICs and synchronous carcinomas, suggesting potential diagnostic and translational research applications. PMID:26181193

  6. Next generation sequencing in neuromuscular diseases

    Science.gov (United States)

    Efthymiou, S; Manole, A; Houlden, H

    2016-01-01

    Purpose of review Neuromuscular diseases are clinically and genetically heterogeneous and probably contains the greatest proportion of causative Mendelian defects than any other group of conditions. These disorders affect muscle and/or nerves with neonatal, childhood or adulthood onset, with significant disability and early mortality. Along with heterogeneity, unidentified and often very large genes, require complementary and comprehensive methods in routine molecular diagnosis. Inevitably this leads to increased diagnostic delays and challenges in the interpretation of genetic variants. Recent findings The application of next-generation sequencing, as a research and diagnostic strategy has made significant progress into solving many of these problems. The analysis of these data is by no means simple and the clinical input is essential to interpret results. Summary In this review, we describe using examples the recent advances in the genetic diagnosis of neuromuscular disorders, in research and clinical practice and the latest developments that are underway in NGS. We also discuss the latest collaborative initiatives such as the Genomics England genome sequencing project that combine rare disease clinical phenotyping with genomics, with the aim of defining the vast majority of rare disease genes in patients as well as modifying risks and pharmacogenomics factors. PMID:27588584

  7. (U) Ristra Next Generation Code Report

    Energy Technology Data Exchange (ETDEWEB)

    Hungerford, Aimee L. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Daniel, David John [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-09-22

    LANL’s Weapons Physics management (ADX) and ASC program office have defined a strategy for exascale-class application codes that follows two supportive, and mutually risk-mitigating paths: evolution for established codes (with a strong pedigree within the user community) based upon existing programming paradigms (MPI+X); and Ristra (formerly known as NGC), a high-risk/high-reward push for a next-generation multi-physics, multi-scale simulation toolkit based on emerging advanced programming systems (with an initial focus on data-flow task-based models exemplified by Legion [5]). Development along these paths is supported by the ATDM, IC, and CSSE elements of the ASC program, with the resulting codes forming a common ecosystem, and with algorithm and code exchange between them anticipated. Furthermore, solution of some of the more challenging problems of the future will require a federation of codes working together, using established-pedigree codes in partnership with new capabilities as they come on line. The role of Ristra as the high-risk/high-reward path for LANL’s codes is fully consistent with its role in the Advanced Technology Development and Mitigation (ATDM) sub-program of ASC (see Appendix C), in particular its emphasis on evolving ASC capabilities through novel programming models and data management technologies.

  8. Next generation environment for collaborative research

    International Nuclear Information System (INIS)

    Collados, D.; Denis, G.; Galvez, P.; Newman, H.

    2001-01-01

    Collaborative environments supporting point to point and multipoint video-conferencing, document and application sharing across both local and wide area networks, video on demand (broadcast and playback) and interactive text facilities will be a crucial element for the development of the next generation of HEP experiments by geographically dispersed collaborations. The 'Virtual Room Video conferencing System' (VRVS) has been developed since 1995, in order to provide a low cost, bandwidth-efficient, extensible means for video conferencing and remote collaboration over networks within the High Energy and Nuclear Physics communities. The VRVS provides worldwide videoconferencing service and collaborative environment to the research and education communities. VRVS uses the Internet2 and ESnet high-performance networks infrastructure to deploy its Web-based system, which now includes more than 5790 registered hosts running VRVS software in more than 50 different countries. VRVS hosts an average of 100-multipoint videoconference and collaborative sessions worldwide every month. There are around 35 reflectors that manage the traffic flow, at HENP labs and universities in the US and Europe. So far, there are 7 Virtual Rooms for World Wide Conferences (involving more than one continent), and 4 Virtual Rooms each for intra-continental conferences in the US, Europe and Asia. VRVS continues to expand and implement new digital video technologies, including H.323 ITU standard integration, MPEG-2 videoconferencing integration, shared environments, and Quality of Service

  9. Next Generation Solar Collectors for CSP

    Energy Technology Data Exchange (ETDEWEB)

    Molnar, Attila [3M Company, St. Paul, MN (United States); Charles, Ruth [3M Company, St. Paul, MN (United States)

    2014-07-31

    The intent of “Next Generation Solar Collectors for CSP” program was to develop key technology elements for collectors in Phase 1 (Budget Period 1), design these elements in Phase 2 (Budget Period 2) and to deploy and test the final collector in Phase 3 (Budget Period 3). 3M and DOE mutually agreed to terminate the program at the end of Budget Period 1, primarily due to timeline issues. However, significant advancements were achieved in developing a next generation reflective material and panel that has the potential to significantly improve the efficiency of CSP systems.

  10. Assessing the Genetics Content in the Next Generation Science Standards

    OpenAIRE

    Lontok, Katherine S.; Zhang, Hubert; Dougherty, Michael J.

    2015-01-01

    Science standards have a long history in the United States and currently form the backbone of efforts to improve primary and secondary education in science, technology, engineering, and math (STEM). Although there has been much political controversy over the influence of standards on teacher autonomy and student performance, little light has been shed on how well standards cover science content. We assessed the coverage of genetics content in the Next Generation Science Standards (NGSS) using...

  11. Next Generation Safeguards Initiative: 2010 and Beyond

    International Nuclear Information System (INIS)

    Whitney, J.M.; LaMontagne, S.; Sunshine, A.; Lockwood, D.; Peranteau, D.; Dupuy, G.

    2010-01-01

    Strengthening the international safeguards system is a key element of the U.S. non-proliferation policy agenda as evidenced by President Obama's call for more 'resources and authority to strengthen international inspections' in his April 2009 Prague speech. Through programs such as the recently-launched Next Generation Safeguards Initiative (NGSI) and the long standing U.S. Program of Technical Assistance to IAEA Safeguards, the United States is working to implement this vision. The U.S. Department of Energy's National Nuclear Security Administration launched NGSI in 2008 to develop the policies, concepts, technologies, expertise, and international safeguards infrastructure necessary to strengthen and sustain the international safeguards system as it evolves to meet new challenges. Following a successful 2009, NGSI has made significant progress toward these goals in 2010. NGSI has recently completed a number of policy studies on advanced safeguards concepts and sponsored several workshops, including a second international meeting on Harmonization of International Safeguards Infrastructure Development in Vienna. The program is also continuing multi-year projects to investigate advanced non-destructive assay techniques, enhance recruitment and training efforts, and strengthen international cooperation on safeguards. In December 2010, NGSI will host the Third Annual International Meeting on International Safeguards in Washington, DC, which will draw together key stakeholders from government, the nuclear industry, and the IAEA to further develop and promote a common understanding of Safeguards by Design principles and goals, and to identify opportunities for practical application of the concept. This paper presents a review of NGSI program activities in 2010 and previews plans for upcoming activities. (author)

  12. NEXT GENERATION MELTER OPTIONEERING STUDY - INTERIM REPORT

    Energy Technology Data Exchange (ETDEWEB)

    GRAY MF; CALMUS RB; RAMSEY G; LOMAX J; ALLEN H

    2010-10-19

    The next generation melter (NOM) development program includes a down selection process to aid in determining the recommended vitrification technology to implement into the WTP at the first melter change-out which is scheduled for 2025. This optioneering study presents a structured value engineering process to establish and assess evaluation criteria that will be incorporated into the down selection process. This process establishes an evaluation framework that will be used progressively throughout the NGM program, and as such this interim report will be updated on a regular basis. The workshop objectives were achieved. In particular: (1) Consensus was reached with stakeholders and technology providers represented at the workshop regarding the need for a decision making process and the application of the D{sub 2}0 process to NGM option evaluation. (2) A framework was established for applying the decision making process to technology development and evaluation between 2010 and 2013. (3) The criteria for the initial evaluation in 2011 were refined and agreed with stakeholders and technology providers. (4) The technology providers have the guidance required to produce data/information to support the next phase of the evaluation process. In some cases it may be necessary to reflect the data/information requirements and overall approach to the evaluation of technology options against specific criteria within updated Statements of Work for 2010-2011. Access to the WTP engineering data has been identified as being very important for option development and evaluation due to the interface issues for the NGM and surrounding plant. WRPS efforts are ongoing to establish precisely data that is required and how to resolve this Issue. It is intended to apply a similarly structured decision making process to the development and evaluation of LAW NGM options.

  13. Recent progress in nanostructured next-generation field emission devices

    Science.gov (United States)

    Mittal, Gaurav; Lahiri, Indranil

    2014-08-01

    Field emission has been known to mankind for more than a century, and extensive research in this field for the last 40-50 years has led to development of exciting applications such as electron sources, miniature x-ray devices, display materials, etc. In the last decade, large-area field emitters were projected as an important material to revolutionize healthcare and medical devices, and space research. With the advent of nanotechnology and advancements related to carbon nanotubes, field emitters are demonstrating highly enhanced performance and novel applications. Next-generation emitters need ultra-high emission current density, high brightness, excellent stability and reproducible performance. Novel design considerations and application of new materials can lead to achievement of these capabilities. This article presents an overview of recent developments in this field and their effects on improved performance of field emitters. These advancements are demonstrated to hold great potential for application in next-generation field emission devices.

  14. Recent progress in nanostructured next-generation field emission devices

    International Nuclear Information System (INIS)

    Mittal, Gaurav; Lahiri, Indranil

    2014-01-01

    Field emission has been known to mankind for more than a century, and extensive research in this field for the last 40–50 years has led to development of exciting applications such as electron sources, miniature x-ray devices, display materials, etc. In the last decade, large-area field emitters were projected as an important material to revolutionize healthcare and medical devices, and space research. With the advent of nanotechnology and advancements related to carbon nanotubes, field emitters are demonstrating highly enhanced performance and novel applications. Next-generation emitters need ultra-high emission current density, high brightness, excellent stability and reproducible performance. Novel design considerations and application of new materials can lead to achievement of these capabilities. This article presents an overview of recent developments in this field and their effects on improved performance of field emitters. These advancements are demonstrated to hold great potential for application in next-generation field emission devices. (topical review)

  15. Optimizing the next generation optical access networks

    DEFF Research Database (Denmark)

    Amaya Fernández, Ferney Orlando; Soto, Ana Cardenas; Tafur Monroy, Idelfonso

    2009-01-01

    Several issues in the design and optimization of the next generation optical access network (NG-OAN) are presented. The noise, the distortion and the fiber optic nonlinearities are considered to optimize the video distribution link in a passive optical network (PON). A discussion of the effect...

  16. Achieving universal access to next generation networks

    DEFF Research Database (Denmark)

    Falch, Morten; Henten, Anders

    The paper examines investment dimensions of next generation networks in a universal service perspective in a European context. The question is how new network infrastructures for getting access to communication, information and entertainment services in the present and future information society...

  17. IPv6: The Next Generation Internet Protocol

    Indian Academy of Sciences (India)

    GENERAL I ARTICLE. IPv6: The Next Generation Internet Protocol. 1. IPv4 and its Shortcomings. Harsha Srinath is currently pursuing his MS degree in Computer. Science at the Center for. Advanced Computer. Studies (CACS) in. University of Louisiana at. Lafayette, USA. His research interests include networking with an.

  18. Next Generation Drivetrain Development and Test Program

    Energy Technology Data Exchange (ETDEWEB)

    Keller, Jonathan; Erdman, Bill; Blodgett, Doug; Halse, Chris; Grider, Dave

    2015-11-03

    This presentation was given at the Wind Energy IQ conference in Bremen, Germany, November 30 through December 2, 2105. It focused on the next-generation drivetrain architecture and drivetrain technology development and testing (including gearbox and inverter software and medium-voltage inverter modules.

  19. IPv6: The Next Generation Internet Protocol

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 3. IPv6: The Next Generation Internet Protocol - IPv4 and its Shortcomings. Harsha Srinath. General Article Volume 8 Issue 3 March 2003 pp 33-41. Fulltext. Click here to view fulltext PDF. Permanent link:

  20. IPv6: The Next Generation Internet Protocol

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 4. IPv6: The Next Generation Internet Protocol - New Features in IPv6. Harsha Srinath. General Article Volume 8 Issue 4 April 2003 pp 8-16. Fulltext. Click here to view fulltext PDF. Permanent link:

  1. Implementing the Next Generation Science Standards

    Science.gov (United States)

    Penuel, William R.; Harris, Christopher J.; DeBarger, Angela Haydel

    2015-01-01

    The Next Generation Science Standards embody a new vision for science education grounded in the idea that science is both a body of knowledge and a set of linked practices for developing knowledge. The authors describe strategies that they suggest school and district leaders consider when designing strategies to support NGSS implementation.

  2. Educating the next generation of nature entrepreneurs

    Science.gov (United States)

    Judith C. Jobse; Loes Witteveen; Judith Santegoets; Daan van der Linde

    2015-01-01

    With this paper, it is illustrated that a focus on entrepreneurship training in the nature and wilderness sector is relevant for diverse organisations and situations. The first curricula on nature entrepreneurship are currently being developed. In this paper the authors describe a project that focusses on educating the next generation of nature entrepreneurs, reflect...

  3. Data Analysis and Next Generation Assessments

    Science.gov (United States)

    Pon, Kathy

    2013-01-01

    For the last decade, much of the work of California school administrators has been shaped by the accountability of the No Child Left Behind Act. Now as they stand at the precipice of Common Core Standards and next generation assessments, it is important to reflect on the proficiency educators have attained in using data to improve instruction and…

  4. Next-generation LWRs development toward realization

    International Nuclear Information System (INIS)

    Mitsumata, Hiroki; Kasai, S.; Ohga, Y.; Kurosaki, T.

    2010-01-01

    This special article introduced the round-table talk of 'next-generation LWRs development toward realization' at the issue of an intermediate evaluation report about technology development of next-generation LWRs in 2010. 'Recent trends around nuclear energy and next-generation LWRs development' and 'summary of the report' were also included. After a 2-year feasibility study on development of next-generation LWRs, the vision of this development has been established as follows; the new designs of HP-BWR and HP-PWR, based on ABWR and APWR, are to lead to a large reduction in construction and generation costs and a 30% reduction of spent fuel quantity with improved safety, 30-month construction and a design life of 80 years with 24-month operating cycle. In 2008 the project was established within the Institute of Applied Energy to pursue this vision, involving three manufacturers. Over eight years, the project is to develop designs of BWR and PWR with 1700-1800 MWe. Basic designs are to be finished by 2015, with significant deployment as new alternative reactors in Japan or internationally by 2030. (T. Tanaka)

  5. Next-generation fiber lasers enabled by high-performance components

    Science.gov (United States)

    Kliner, D. A. V.; Victor, B.; Rivera, C.; Fanning, G.; Balsley, D.; Farrow, R. L.; Kennedy, K.; Hampton, S.; Hawke, R.; Soukup, E.; Reynolds, M.; Hodges, A.; Emery, J.; Brown, A.; Almonte, K.; Nelson, M.; Foley, B.; Dawson, D.; Hemenway, D. M.; Urbanek, W.; DeVito, M.; Bao, L.; Koponen, J.; Gross, K.

    2018-02-01

    Next-generation industrial fiber lasers enable challenging applications that cannot be addressed with legacy fiber lasers. Key features of next-generation fiber lasers include robust back-reflection protection, high power stability, wide power tunability, high-speed modulation and waveform generation, and facile field serviceability. These capabilities are enabled by high-performance components, particularly pump diodes and optical fibers, and by advanced fiber laser designs. We summarize the performance and reliability of nLIGHT diodes, fibers, and next-generation industrial fiber lasers at power levels of 500 W - 8 kW. We show back-reflection studies with up to 1 kW of back-reflected power, power-stability measurements in cw and modulated operation exhibiting sub-1% stability over a 5 - 100% power range, and high-speed modulation (100 kHz) and waveform generation with a bandwidth 20x higher than standard fiber lasers. We show results from representative applications, including cutting and welding of highly reflective metals (Cu and Al) for production of Li-ion battery modules and processing of carbon fiber reinforced polymers.

  6. NASA's Next Generation Space Geodesy Program

    Science.gov (United States)

    Merkowitz, S. M.; Desai, S. D.; Gross, R. S.; Hillard, L. M.; Lemoine, F. G.; Long, J. L.; Ma, C.; McGarry, J. F.; Murphy, D.; Noll, C. E.; hide

    2012-01-01

    Requirements for the ITRF have increased dramatically since the 1980s. The most stringent requirement comes from critical sea level monitoring programs: a global accuracy of 1.0 mm, and 0.1mm/yr stability, a factor of 10 to 20 beyond current capability. Other requirements for the ITRF coming from ice mass change, ground motion, and mass transport studies are similar. Current and future satellite missions will have ever-increasing measurement capability and will lead to increasingly sophisticated models of these and other changes in the Earth system. Ground space geodesy networks with enhanced measurement capability will be essential to meeting the ITRF requirements and properly interpreting the satellite data. These networks must be globally distributed and built for longevity, to provide the robust data necessary to generate improved models for proper interpretation of the observed geophysical signals. NASA has embarked on a Space Geodesy Program with a long-range goal to build, deploy and operate a next generation NASA Space Geodetic Network (SGN). The plan is to build integrated, multi-technique next-generation space geodetic observing systems as the core contribution to a global network designed to produce the higher quality data required to maintain the Terrestrial Reference Frame and provide information essential for fully realizing the measurement potential of the current and coming generation of Earth Observing spacecraft. Phase 1 of this project has been funded to (1) Establish and demonstrate a next-generation prototype integrated Space Geodetic Station at Goddard's Geophysical and Astronomical Observatory (GGAO), including next-generation SLR and VLBI systems along with modern GNSS and DORIS; (2) Complete ongoing Network Design Studies that describe the appropriate number and distribution of next-generation Space Geodetic Stations for an improved global network; (3) Upgrade analysis capability to handle the next-generation data; (4) Implement a modern

  7. FlashPort - The Next Generation In E-Portfolios? - The Use of Portable Applications as e-Portfolio Tools in Teacher Education

    Directory of Open Access Journals (Sweden)

    Duncan Mackrill

    2008-12-01

    Full Text Available Eportfolios are becoming increasingly important in HE in the UK and have tended to move towards web-based versions which are either institutionally owned, or hosted by a commercial company. Whilst there are certainly advantages with these models there are important considerations over the transferability and ownership of students' work. This paper reports on the design and implementation of an alternative model, using a set of portable applications as ePortfolio tools for use by initial teacher education students. The work focuses on adding a range of small stand alone applications to USB flash drives along with a set of files and templates focusing on the students' studies. To this we have given a generic name - 'FlashPort' - and developed a specific version for trainee teachers that we have called 'eLiPort'. The research takes the form of an intervention, following the introduction of eLiPort to a group of trainee teachers on a one year Secondary (High School teaching course in the UK. Findings of the initial research are discussed along with how the challenges were addressed, its use in practice and the implications for the future.

  8. LASER APPLICATIONS AND OTHER TOPICS IN QUANTUM ELECTRONICS: Laser-induced extreme UV radiation sources for manufacturing next-generation integrated circuits

    Science.gov (United States)

    Borisov, V. M.; Vinokhodov, A. Yu; Ivanov, A. S.; Kiryukhin, Yu B.; Mishchenko, V. A.; Prokof'ev, A. V.; Khristoforov, O. B.

    2009-10-01

    The development of high-power discharge sources emitting in the 13.5±0.135-nm spectral band is of current interest because they are promising for applications in industrial EUV (extreme ultraviolet) lithography for manufacturing integrated circuits according to technological precision standards of 22 nm and smaller. The parameters of EUV sources based on a laser-induced discharge in tin vapours between rotating disc electrodes are investigated. The properties of the discharge initiation by laser radiation at different wavelengths are established and the laser pulse parameters providing the maximum energy characteristics of the EUV source are determined. The EUV source developed in the study emits an average power of 276 W in the 13.5±0.135-nm spectral band on conversion to the solid angle 2π sr in the stationary regime at a pulse repetition rate of 3000 Hz.

  9. Feasibility study of an optical resonator for applications in neutral-beam injection systems for the next generation of nuclear fusion reactors

    International Nuclear Information System (INIS)

    Fiorucci, Donatella

    2015-01-01

    This work is part of a larger project called SIPHORE (Single gap Photo-neutralizer energy Recovery injector), which aims to enhance the overall efficiency of one of the mechanisms through which the plasma is heated, in a nuclear fusion reactor, i.e. the Neutral Beam Injection (NBI) system. An important component of a NBI system is the neutralizer of high energetic ion beams. SIPHORE proposes to substitute the gas cell neutralizer, used in the current NBI systems, with a photo-neutralizer exploiting the photo-detachment process within Fabry Perot cavities. This mechanism should allow a relevant NBI global efficiency of η≥ 60%, significantly higher than the one currently possible (η≤25% for ITER). The present work concerns the feasibility study of an optical cavity with suitable properties for applications in NBI systems. Within this context, the issue of the determination of an appropriated optical cavity design has been firstly considered and the theoretical and experimental analysis of a particular optical resonator has been carried on. The problems associated with the high levels of intracavity optical power (∼3 MW) required for an adequate photo-neutralization rate have then been faced. In this respect, we addressed both the problem of the thermal effects on the cavity mirrors due to their absorption of intra-cavity optical power (∼1 W) and the one associated to the necessity of a high powerful input laser beam (∼1 kW) to feed the optical resonator. (author)

  10. Application of next-generation sequencing technology to study genetic diversity and identify unique SNP markers in bread wheat from Kazakhstan.

    Science.gov (United States)

    Shavrukov, Yuri; Suchecki, Radoslaw; Eliby, Serik; Abugalieva, Aigul; Kenebayev, Serik; Langridge, Peter

    2014-09-28

    New SNP marker platforms offer the opportunity to investigate the relationships between wheat cultivars from different regions and assess the mechanism and processes that have led to adaptation to particular production environments. Wheat breeding has a long history in Kazakhstan and the aim of this study was to explore the relationship between key varieties from Kazakhstan and germplasm from breeding programs for other regions. The study revealed 5,898 polymorphic markers amongst ten cultivars, of which 2,730 were mapped in the consensus genetic map. Mapped SNP markers were distributed almost equally across the A and B genomes, with between 279 and 484 markers assigned to each chromosome. Marker coverage was approximately 10-fold lower in the D genome. There were 863 SNP markers identified as unique to specific cultivars, and clusters of these markers (regions containing more than three closely mapped unique SNPs) showed specific patterns on the consensus genetic map for each cultivar. Significant intra-varietal genetic polymorphism was identified in three cultivars (Tzelinnaya 3C, Kazakhstanskaya rannespelaya and Kazakhstanskaya 15). Phylogenetic analysis based on inter-varietal polymorphism showed that the very old cultivar Erythrospermum 841 was the most genetically distinct from the other nine cultivars from Kazakhstan, falling in a clade together with the American cultivar Sonora and genotypes from Central and South Asia. The modern cultivar Kazakhstanskaya 19 also fell into a separate clade, together with the American cultivar Thatcher. The remaining eight cultivars shared a single sub-clade but were categorised into four clusters. The accumulated data for SNP marker polymorphisms amongst bread wheat genotypes from Kazakhstan may be used for studying genetic diversity in bread wheat, with potential application for marker-assisted selection and the preparation of a set of genotype-specific markers.

  11. The electrochemical characteristics and applicability of an amorphous sulfide based solid ion conductor for the next generation solid-state lithium secondary batteries.

    Directory of Open Access Journals (Sweden)

    Yuichi eAihara

    2016-05-01

    Full Text Available Sulfide based solid electrolytes are of considerable practical interest for all solid-state batteries due to their high ionic conductivity and softness at room temperature. In particular, iodine containing lithium thiophosphate is known to exhibit high ionic conductivity but its applicability in solid-state battery remains to be examined. To demonstrate the possibility of the iodine doped solid electrolyte (SE, LiI-Li3PS4 was used to construct two different types of test cells were prepared, Li/SE/S and Li/SE/LiNi0.80Co0.15Al0.05 cells. The solid electrolyte, LiI-Li3PS4 showed a high ionic conductivity approximately 1.2 mScm-1 at 25 ℃. Within 100 cycles, the capacity retention was better in Li/SE/S cell, and the red-ox shuttle was not observed due to physical blockage of SE layer. The capacity fade was approximately 4% from the maximum capacity observed at 10th cycle, after 100 cycles in Li/SE/S cell. On the contrary, the capacity fade was much larger in Li/SE/LiNi0.80Co0.15Al0.05 cell, probably due to the decomposition of the electrolyte at the operating potential range. Nevertheless, both the Li/SE/LiNi0.80Co0.15Al0.05 and Li/SE/S cells exhibited the high coulombic efficiencies above 99.6% and 99.9% during charge-discharge cycle test, respectively. This fact indicates that a high energy density can be possible without an excess lithium metal anode. In addition, it was particularly interesting that the SE showed a reversible capacity about 260 mAhg-1-SE. This electrolyte may have not only as a role of the ion conduction, but also as a catholite.

  12. Molecular Characterization of Transgenic Events Using Next Generation Sequencing Approach

    Science.gov (United States)

    Mammadov, Jafar; Ye, Liang; Soe, Khaing; Richey, Kimberly; Cruse, James; Zhuang, Meibao; Gao, Zhifang; Evans, Clive; Rounsley, Steve; Kumpatla, Siva P.

    2016-01-01

    Demand for the commercial use of genetically modified (GM) crops has been increasing in light of the projected growth of world population to nine billion by 2050. A prerequisite of paramount importance for regulatory submissions is the rigorous safety assessment of GM crops. One of the components of safety assessment is molecular characterization at DNA level which helps to determine the copy number, integrity and stability of a transgene; characterize the integration site within a host genome; and confirm the absence of vector DNA. Historically, molecular characterization has been carried out using Southern blot analysis coupled with Sanger sequencing. While this is a robust approach to characterize the transgenic crops, it is both time- and resource-consuming. The emergence of next-generation sequencing (NGS) technologies has provided highly sensitive and cost- and labor-effective alternative for molecular characterization compared to traditional Southern blot analysis. Herein, we have demonstrated the successful application of both whole genome sequencing and target capture sequencing approaches for the characterization of single and stacked transgenic events and compared the results and inferences with traditional method with respect to key criteria required for regulatory submissions. PMID:26908260

  13. Machine learning and next-generation asteroid surveys

    Science.gov (United States)

    Nugent, Carrie R.; Dailey, John; Cutri, Roc M.; Masci, Frank J.; Mainzer, Amy K.

    2017-10-01

    Next-generation surveys such as NEOCam (Mainzer et al., 2016) will sift through tens of millions of point source detections daily to detect and discover asteroids. This requires new, more efficient techniques to distinguish between solar system objects, background stars and galaxies, and artifacts such as cosmic rays, scattered light and diffraction spikes.Supervised machine learning is a set of algorithms that allows computers to classify data on a training set, and then apply that classification to make predictions on new datasets. It has been employed by a broad range of fields, including computer vision, medical diagnoses, economics, and natural language processing. It has also been applied to astronomical datasets, including transient identification in the Palomar Transient Factory pipeline (Masci et al., 2016), and in the Pan-STARRS1 difference imaging (D. E. Wright et al., 2015).As part of the NEOCam extended phase A work we apply machine learning techniques to the problem of asteroid detection. Asteroid detection is an ideal application of supervised learning, as there is a wealth of metrics associated with each extracted source, and suitable training sets are easily created. Using the vetted NEOWISE dataset (E. L. Wright et al., 2010, Mainzer et al., 2011) as a proof-of-concept of this technique, we applied the python package sklearn. We report on reliability, feature set selection, and the suitability of various algorithms.

  14. Traffic Management for Next Generation Transport Networks

    DEFF Research Database (Denmark)

    Yu, Hao

    Video services are believed to be prevalent in the next generation transport networks. The popularity of these bandwidth-intensive services, such as Internet Protocol Television (IPTV), online gaming, and Videoon- Demand (VoD), are currently driving the network service providers to upgrade...... their network capacities. However, in order to provide more advanced video services than simply porting the traditional television services to the network, the service provider needs to do more than just augment the network capacity. Advanced traffic management capability is one of the relevant abilities...... required by the next generation transport network to provide Quality-of-Service (QoS) guaranteed video services. Augmenting network capacity and upgrading network nodes indicate long deployment period, replacement of equipment and thus significant cost to the network service providers. This challenge may...

  15. Next generation biofuel engineering in prokaryotes

    Science.gov (United States)

    Gronenberg, Luisa S.; Marcheschi, Ryan J.; Liao, James C.

    2014-01-01

    Next-generation biofuels must be compatible with current transportation infrastructure and be derived from environmentally sustainable resources that do not compete with food crops. Many bacterial species have unique properties advantageous to the production of such next-generation fuels. However, no single species possesses all characteristics necessary to make high quantities of fuels from plant waste or CO2. Species containing a subset of the desired characteristics are used as starting points for engineering organisms with all desired attributes. Metabolic engineering of model organisms has yielded high titer production of advanced fuels, including alcohols, isoprenoids and fatty acid derivatives. Technical developments now allow engineering of native fuel producers, as well as lignocellulolytic and autotrophic bacteria, for the production of biofuels. Continued research on multiple fronts is required to engineer organisms for truly sustainable and economical biofuel production. PMID:23623045

  16. Fetal Kidney Anomalies: Next Generation Sequencing

    DEFF Research Database (Denmark)

    Rasmussen, Maria; Sunde, Lone; Nielsen, Marlene Louise

    Aim and Introduction Identification of abnormal kidneys in the fetus may lead to termination of the pregnancy and raises questions about the underlying cause and recurrence risk in future pregnancies. In this study, we investigate the effectiveness of targeted next generation sequencing in fetuse...... no mutations were identified, have been selected for exome sequencing in order to uncover novel genes associated to fetal kidney anomalies.......Aim and Introduction Identification of abnormal kidneys in the fetus may lead to termination of the pregnancy and raises questions about the underlying cause and recurrence risk in future pregnancies. In this study, we investigate the effectiveness of targeted next generation sequencing in fetuses...... postmortem examination. The approximately 110 genes included in the targeted panel were chosen on the basis of their potential involvement in embryonic kidney development, cystic kidney disease, or the renin-angiotensin system. DNA was extracted from fetal tissue samples or cultured chorion villus cells...

  17. Next Generation Avionics System for Satellite Application

    Science.gov (United States)

    Wiegand, M.; Schmidt, G.; Hahn, M.

    This paper describes the new modular avionics system developed at Astrium GmbH in Munich in the frame of Gammabus, a DLR-funded development for constellation programs. Modularity, reusability and time to market are major goals of the development. The system consists of the on-board computer core modules, namely processor module, telemetry/telecommand/reconfiguration/safeguard-memory module and power converter module, an onboard software computing environment as well as a development and verification environment including a real-time testbed and ground station interface (SCOS) to support mission simulation tests. The new concept is taking advantage of improvements in microelectronics and software technology to improve performance while reducing costs.

  18. NASA's Next Generation Space Geodesy Network

    Science.gov (United States)

    Desai, S. D.; Gross, R. S.; Hilliard, L.; Lemoine, F. G.; Long, J. L.; Ma, C.; McGarry, J. F.; Merkowitz, S. M.; Murphy, D.; Noll, C. E.; hide

    2012-01-01

    NASA's Space Geodesy Project (SGP) is developing a prototype core site for a next generation Space Geodetic Network (SGN). Each of the sites in this planned network co-locate current state-of-the-art stations from all four space geodetic observing systems, GNSS, SLR, VLBI, and DORIS, with the goal of achieving modern requirements for the International Terrestrial Reference Frame (ITRF). In particular, the driving ITRF requirements for this network are 1.0 mm in accuracy and 0.1 mm/yr in stability, a factor of 10-20 beyond current capabilities. Development of the prototype core site, located at NASA's Geophysical and Astronomical Observatory at the Goddard Space Flight Center, started in 2011 and will be completed by the end of 2013. In January 2012, two operational GNSS stations, GODS and GOON, were established at the prototype site within 100 m of each other. Both stations are being proposed for inclusion into the IGS network. In addition, work is underway for the inclusion of next generation SLR and VLBI stations along with a modern DORIS station. An automated survey system is being developed to measure inter-technique vectorties, and network design studies are being performed to define the appropriate number and distribution of these next generation space geodetic core sites that are required to achieve the driving ITRF requirements. We present the status of this prototype next generation space geodetic core site, results from the analysis of data from the established geodetic stations, and results from the ongoing network design studies.

  19. Manufacturing Laboratory for Next Generation Engineers

    Science.gov (United States)

    2013-12-16

    SECURITY CLASSIFICATION OF: The specific aims of this project were: 1) to plan a manufacturing laboratory to educate next generation engineers. 2) to...compressor disc is an example of 5-axis machining. It is a prototype turbo-charger compressor disc machined from aluminum stock . The complex blade... keyboard press "Delete." Bradley University College of Engineering Omax 2626 XP Operating Instructions 11 P r o g r a m Page

  20. Next-Generation Sequencing in Intellectual Disability

    OpenAIRE

    Carvill, Gemma L.; Mefford, Heather C.

    2015-01-01

    Next-generation sequencing technologies have revolutionized gene discovery in patients with intellectual disability (ID) and led to an unprecedented expansion in the number of genes implicated in this disorder. We discuss the strategies that have been used to identify these novel genes for both syndromic and nonsyndromic ID and highlight the phenotypic and genetic heterogeneity that underpin this condition. Finally, we discuss the future of defining the genetic etiology of ID, including the r...

  1. Next-Generation Sequencing in the Mycology Lab.

    Science.gov (United States)

    Zoll, Jan; Snelders, Eveline; Verweij, Paul E; Melchers, Willem J G

    New state-of-the-art techniques in sequencing offer valuable tools in both detection of mycobiota and in understanding of the molecular mechanisms of resistance against antifungal compounds and virulence. Introduction of new sequencing platform with enhanced capacity and a reduction in costs for sequence analysis provides a potential powerful tool in mycological diagnosis and research. In this review, we summarize the applications of next-generation sequencing techniques in mycology.

  2. Design of the next generation target at Lujan center, LANSCE.

    Energy Technology Data Exchange (ETDEWEB)

    Ferres, Laurent [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-07-27

    This is a presentation given at Los Alamos National Laboratory (LANL) on the design of the next generation target at Lujan center, LANSCE. The motivation for this design is to enable new nuclear physics experiments (defense program applications (DANCE)) that are currently limited by neutron intensity or energy resolution available at LANSCE. The target is being redesigned so that the Flight Paths in the upper tier provide a higher intensity in the epithermal and medium energy ranges.

  3. Novel nanostructures for next generation dye-sensitized solar cells

    KAUST Repository

    Tétreault, Nicolas

    2012-01-01

    Herein, we review our latest advancements in nanostructured photoanodes for next generation photovoltaics in general and dye-sensitized solar cells in particular. Bottom-up self-assembly techniques are developed to fabricate large-area 3D nanostructures that enable enhanced charge extraction and light harvesting through optical scattering or photonic crystal effects to improve photocurrent, photovoltage and fill factor. Using generalized techniques to fabricate specialized nanostructures enables specific optoelectronic and physical characteristics like conduction, charge extraction, injection, recombination and light harvesting but also helps improve mechanical flexibility and long-term stability in low cost materials. © 2012 The Royal Society of Chemistry.

  4. Raytheon's next generation compact inline cryocooler architecture

    International Nuclear Information System (INIS)

    Schaefer, B. R.; Bellis, L.; Ellis, M. J.; Conrad, T.

    2014-01-01

    Since the 1970s, Raytheon has developed, built, tested and integrated high performance cryocoolers. Our versatile designs for single and multi-stage cryocoolers provide reliable operation for temperatures from 10 to 200 Kelvin with power levels ranging from 50 W to nearly 600 W. These advanced cryocoolers incorporate clearance seals, flexure suspensions, hermetic housings and dynamic balancing to provide long service life and reliable operation in all relevant environments. Today, sensors face a multitude of cryocooler integration challenges such as exported disturbance, efficiency, scalability, maturity, and cost. As a result, cryocooler selection is application dependent, oftentimes requiring extensive trade studies to determine the most suitable architecture. To optimally meet the needs of next generation passive IR sensors, the Compact Inline Raytheon Stirling 1-Stage (CI-RS1), Compact Inline Raytheon Single Stage Pulse Tube (CI-RP1) and Compact Inline Raytheon Hybrid Stirling/Pulse Tube 2-Stage (CI-RSP2) cryocoolers are being developed to satisfy this suite of requirements. This lightweight, compact, efficient, low vibration cryocooler combines proven 1-stage (RS1 or RP1) and 2-stage (RSP2) cold-head architectures with an inventive set of warm-end mechanisms into a single cooler module, allowing the moving mechanisms for the compressor and the Stirling displacer to be consolidated onto a common axis and in a common working volume. The CI cryocooler is a significant departure from the current Stirling cryocoolers in which the compressor mechanisms are remote from the Stirling displacer mechanism. Placing all of the mechanisms in a single volume and on a single axis provides benefits in terms of package size (30% reduction), mass (30% reduction), thermodynamic efficiency (>20% improvement) and exported vibration performance (≤25 mN peak in all three orthogonal axes at frequencies from 1 to 500 Hz). The main benefit of axial symmetry is that proven balancing

  5. Next-Generation Sequencing for Binary Protein-Protein Interactions

    Directory of Open Access Journals (Sweden)

    Bernhard eSuter

    2015-12-01

    Full Text Available The yeast two-hybrid (Y2H system exploits host cell genetics in order to display binary protein-protein interactions (PPIs via defined and selectable phenotypes. Numerous improvements have been made to this method, adapting the screening principle for diverse applications, including drug discovery and the scale-up for proteome wide interaction screens in human and other organisms. Here we discuss a systematic workflow and analysis scheme for screening data generated by Y2H and related assays that includes high-throughput selection procedures, readout of comprehensive results via next-generation sequencing (NGS, and the interpretation of interaction data via quantitative statistics. The novel assays and tools will serve the broader scientific community to harness the power of NGS technology to address PPI networks in health and disease. We discuss examples of how this next-generation platform can be applied to address specific questions in diverse fields of biology and medicine.

  6. Next-Generation Sequencing: From Understanding Biology to Personalized Medicine

    Directory of Open Access Journals (Sweden)

    Benjamin Meder

    2013-03-01

    Full Text Available Within just a few years, the new methods for high-throughput next-generation sequencing have generated completely novel insights into the heritability and pathophysiology of human disease. In this review, we wish to highlight the benefits of the current state-of-the-art sequencing technologies for genetic and epigenetic research. We illustrate how these technologies help to constantly improve our understanding of genetic mechanisms in biological systems and summarize the progress made so far. This can be exemplified by the case of heritable heart muscle diseases, so-called cardiomyopathies. Here, next-generation sequencing is able to identify novel disease genes, and first clinical applications demonstrate the successful translation of this technology into personalized patient care.

  7. Next-Generation Sequencing for Binary Protein-Protein Interactions.

    Science.gov (United States)

    Suter, Bernhard; Zhang, Xinmin; Pesce, C Gustavo; Mendelsohn, Andrew R; Dinesh-Kumar, Savithramma P; Mao, Jian-Hua

    2015-01-01

    The yeast two-hybrid (Y2H) system exploits host cell genetics in order to display binary protein-protein interactions (PPIs) via defined and selectable phenotypes. Numerous improvements have been made to this method, adapting the screening principle for diverse applications, including drug discovery and the scale-up for proteome wide interaction screens in human and other organisms. Here we discuss a systematic workflow and analysis scheme for screening data generated by Y2H and related assays that includes high-throughput selection procedures, readout of comprehensive results via next-generation sequencing (NGS), and the interpretation of interaction data via quantitative statistics. The novel assays and tools will serve the broader scientific community to harness the power of NGS technology to address PPI networks in health and disease. We discuss examples of how this next-generation platform can be applied to address specific questions in diverse fields of biology and medicine.

  8. SCIENT--smart configurable infrastructure for next-generation telemonitoring.

    Science.gov (United States)

    Gupta, Shashank; Ganz, Aura

    2004-01-01

    The main contribution of this paper is the design and development of a middleware platform to build Next Generation Telemonitoring applications. The framework, called "SCIENT", is smart, providing adaptability to operating environments as a first class feature and is configurable, allowing it to be tailored to different medical applications. SCIENT aims to annul the repetitive work in designing Telemonitoring applications and provides a platform for rapid prototyping, considerably lowering costs. Extendibility, modularity, and evolvability are other important considerations of the design. We present a proof-of-concept implementation of SCIENT and build two applications using the framework to demonstrate the feasibility of our solution.

  9. Educating the Next Generation of Lunar Scientists

    Science.gov (United States)

    Shaner, A. J.; Shipp, S. S.; Allen, J. S.; Kring, D. A.

    2010-12-01

    The Center for Lunar Science and Exploration (CLSE), a collaboration between the Lunar and Planetary Institute (LPI) and NASA’s Johnson Space Center (JSC), is one of seven member teams of the NASA Lunar Science Institute (NLSI). In addition to research and exploration activities, the CLSE team is deeply invested in education and outreach. In support of NASA’s and NLSI’s objective to train the next generation of scientists, CLSE’s High School Lunar Research Project is a conduit through which high school students can actively participate in lunar science and learn about pathways into scientific careers. The High School Lunar Research Project engages teams of high school students in authentic lunar research that envelopes them in the process of science and supports the science goals of the CLSE. Most high school students’ lack of scientific research experience leaves them without an understanding of science as a process. Because of this, each team is paired with a lunar scientist mentor responsible for guiding students through the process of conducting a scientific investigation. Before beginning their research, students undertake “Moon 101,” designed to familiarize them with lunar geology and exploration. Students read articles covering various lunar geology topics and analyze images from past and current lunar missions to become familiar with available lunar data sets. At the end of “Moon 101”, students present a characterization of the geology and chronology of features surrounding the Apollo 11 landing site. To begin their research, teams choose a research subject from a pool of topics compiled by the CLSE staff. After choosing a topic, student teams ask their own research questions, within the context of the larger question, and design their own research approach to direct their investigation. At the conclusion of their research, teams present their results and, after receiving feedback, create and present a conference style poster to a panel of

  10. A Toolkit for bulk PCR-based marker design from next-generation sequence data: application for development of a framework linkage map in bulb onion (Allium cepa L.

    Directory of Open Access Journals (Sweden)

    Baldwin Samantha

    2012-11-01

    Full Text Available Abstract Background Although modern sequencing technologies permit the ready detection of numerous DNA sequence variants in any organisms, converting such information to PCR-based genetic markers is hampered by a lack of simple, scalable tools. Onion is an example of an under-researched crop with a complex, heterozygous genome where genome-based research has previously been hindered by limited sequence resources and genetic markers. Results We report the development of generic tools for large-scale web-based PCR-based marker design in the Galaxy bioinformatics framework, and their application for development of next-generation genetics resources in a wide cross of bulb onion (Allium cepa L.. Transcriptome sequence resources were developed for the homozygous doubled-haploid bulb onion line ‘CUDH2150’ and the genetically distant Indian landrace ‘Nasik Red’, using 454™ sequencing of normalised cDNA libraries of leaf and shoot. Read mapping of ‘Nasik Red’ reads onto ‘CUDH2150’ assemblies revealed 16836 indel and SNP polymorphisms that were mined for portable PCR-based marker development. Tools for detection of restriction polymorphisms and primer set design were developed in BioPython and adapted for use in the Galaxy workflow environment, enabling large-scale and targeted assay design. Using PCR-based markers designed with these tools, a framework genetic linkage map of over 800cM spanning all chromosomes was developed in a subset of 93 F2 progeny from a very large F2 family developed from the ‘Nasik Red’ x ‘CUDH2150’ inter-cross. The utility of tools and genetic resources developed was tested by designing markers to transcription factor-like polymorphic sequences. Bin mapping these markers using a subset of 10 progeny confirmed the ability to place markers within 10 cM bins, enabling increased efficiency in marker assignment and targeted map refinement. The major genetic loci conditioning red bulb colour (R and fructan

  11. Next Generation Flight Displays Using HTML5

    Science.gov (United States)

    Greenwood, Brian

    2016-01-01

    The Human Integrated Vehicles and Environments (HIVE) lab at Johnson Space Center (JSC) is focused on bringing together inter-disciplinary talent to design and integrate innovative human interface technologies for next generation manned spacecraft. As part of this objective, my summer internship project centered on an ongoing investigation in to building flight displays using the HTML5 standard. Specifically, the goals of my project were to build and demo "flight-like" crew and wearable displays as well as create a webserver for live systems being developed by the Advanced Exploration Systems (AES) program. In parallel to my project, a LabVIEW application, called a display server, was created by the HIVE that uses an XTCE (XML (Extensible Markup Language) Telemetry and Command Exchange) parser and CCSDS (Consultative Committee for Space Data System) space packet decoder to translate telemetry items sent by the CFS (Core Flight Software) over User Datagram Protocol (UDP). It was the webserver's job to receive these UDP messages and send them to the displays. To accomplish this functionality, I utilized Node.js and the accompanying Express framework. On the display side, I was responsible for creating the power system (AMPS) displays. I did this by using HTML5, CSS and JavaScript to create web pages that could update and change dynamically based on the data they received from the webserver. At this point, I have not started on the commanding, being able to send back to the CFS, portion of the displays but hope to have this functionality working by the completion of my internship. I also created a way to test the webserver's functionality without the display server by making a JavaScript application that read in a comma-separate values (CSV) file and converted it to XML which was then sent over UDP. One of the major requirements of my project was to build everything using as little preexisting code as possible, which I accomplished by only using a handful of Java

  12. Next Generation NASA Initiative for Space Geodesy

    Science.gov (United States)

    Merkowitz, S. M.; Desai, S.; Gross, R. S.; Hilliard, L.; Lemoine, F. G.; Long, J. L.; Ma, C.; McGarry J. F.; Murphy, D.; Noll, C. E.; hide

    2012-01-01

    Space geodesy measurement requirements have become more and more stringent as our understanding of the physical processes and our modeling techniques have improved. In addition, current and future spacecraft will have ever-increasing measurement capability and will lead to increasingly sophisticated models of changes in the Earth system. Ground-based space geodesy networks with enhanced measurement capability will be essential to meeting these oncoming requirements and properly interpreting the sate1!ite data. These networks must be globally distributed and built for longevity, to provide the robust data necessary to generate improved models for proper interpretation ofthe observed geophysical signals. These requirements have been articulated by the Global Geodetic Observing System (GGOS). The NASA Space Geodesy Project (SGP) is developing a prototype core site as the basis for a next generation Space Geodetic Network (SGN) that would be NASA's contribution to a global network designed to produce the higher quality data required to maintain the Terrestrial Reference Frame and provide information essential for fully realizing the measurement potential of the current and coming generation of Earth Observing spacecraft. Each of the sites in the SGN would include co-located, state of-the-art systems from all four space geodetic observing techniques (GNSS, SLR, VLBI, and DORIS). The prototype core site is being developed at NASA's Geophysical and Astronomical Observatory at Goddard Space Flight Center. The project commenced in 2011 and is scheduled for completion in late 2013. In January 2012, two multiconstellation GNSS receivers, GODS and GODN, were established at the prototype site as part of the local geodetic network. Development and testing are also underway on the next generation SLR and VLBI systems along with a modern DORIS station. An automated survey system is being developed to measure inter-technique vector ties, and network design studies are being

  13. Next Generation Luminaire (NGL) Downlight Demonstration Project, Hilton Columbus Downtown

    Energy Technology Data Exchange (ETDEWEB)

    Davis, R. G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Perrin, T. E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2014-09-30

    At the Hilton Columbus Downtown hotel in Ohio, DOE's Better Buildings Alliance conducted a demonstration of Next Generation Luminaires-winning downlights installed in all guest rooms and suites prior to the hotel's 2012 opening. After a post-occupancy assessment, the LED downlights not only provided the aesthetic appearance and dimming functionality desired, but also provided 50% energy savings relative to a comparable CFL downlight and enabled the lighting power to be more than 20% below that allowed by code.

  14. Next generation distributed computing for cancer research.

    Science.gov (United States)

    Agarwal, Pankaj; Owzar, Kouros

    2014-01-01

    Advances in next generation sequencing (NGS) and mass spectrometry (MS) technologies have provided many new opportunities and angles for extending the scope of translational cancer research while creating tremendous challenges in data management and analysis. The resulting informatics challenge is invariably not amenable to the use of traditional computing models. Recent advances in scalable computing and associated infrastructure, particularly distributed computing for Big Data, can provide solutions for addressing these challenges. In this review, the next generation of distributed computing technologies that can address these informatics problems is described from the perspective of three key components of a computational platform, namely computing, data storage and management, and networking. A broad overview of scalable computing is provided to set the context for a detailed description of Hadoop, a technology that is being rapidly adopted for large-scale distributed computing. A proof-of-concept Hadoop cluster, set up for performance benchmarking of NGS read alignment, is described as an example of how to work with Hadoop. Finally, Hadoop is compared with a number of other current technologies for distributed computing.

  15. Next Generation Safeguards Initiative: Human Capital Development

    International Nuclear Information System (INIS)

    Scholz, M.; Irola, G.; Glynn, K.

    2015-01-01

    Since 2008, the Human Capital Development (HCD) subprogramme of the U.S. National Nuclear Security Administration's (NNSA) Next Generation Safeguards Initiative (NGSI) has supported the recruitment, education, training, and retention of the next generation of international safeguards professionals to meet the needs of both the International Atomic Energy Agency (IAEA) and the United States. Specifically, HCD's efforts respond to data indicating that 82% of safeguards experts at U.S. Laboratories will have left the workforce within 15 years. This paper provides an update on the status of the subprogramme since its last presentation at the IAEA Safeguards Symposium in 2010. It highlights strengthened, integrated efforts in the areas of graduate and post-doctoral fellowships, young and midcareer professional support, short safeguards courses, and university engagement. It also discusses lessons learned from the U.S. experience in safeguards education and training as well as the importance of long-range strategies to develop a cohesive, effective, and efficient human capital development approach. (author)

  16. Next generation digital microfluidic technology: Electrophoresis of charged droplets

    Energy Technology Data Exchange (ETDEWEB)

    Im, Do Jin [Pukyong National University, Busan (Korea, Republic of)

    2015-06-15

    Contact charging of a conducting droplet in a dielectric medium is introduced as a novel and useful digital microfluidic technology as well as an interesting scientific phenomenon. The history of this phenomenon, starting from original observations to its interpretations and applications, is presented. The basic principle of the droplet contact charging is also presented. Several fundamental aspects of the droplet contact charging from view points of electrochemistry, surface science, electrocoalescence, and electrohydrodynamics are mentioned. Some promising results for future applications and potential features as a next generation digital microfluidic technology are discussed, especially for 3D organ printing. Finally, implications and significance of the proposed technology for chemical engineering community are discussed.

  17. Social Intelligence: Next Generation Business Intelligence

    Energy Technology Data Exchange (ETDEWEB)

    Troy Hiltbrand

    2010-09-01

    In order for Business Intelligence to truly move beyond where it is today, a shift in approach must occur. Currently, much of what is accomplished in the realm of Business Intelligence relies on reports and dashboards to summarize and deliver information to end users. As we move into the future, we need to get beyond these reports and dashboards to a point where we break out the individual metrics that are embedded in these reports and interact with these components independently. Breaking these pieces of information out of the confines of reports and dashboards will allow them to be dynamically assembled for delivery in the way that makes most sense to each consumer. With this change in ideology, Business Intelligence will move from the concept of collections of objects, or reports and dashboards, to individual objects, or information components. The Next Generation Business Intelligence suite will translate concepts popularized in Facebook, Flickr, and Digg into enterprise worthy communication vehicles.

  18. The Next Generation of Planetary Atmospheric Probes

    Science.gov (United States)

    Houben, Howard

    2005-01-01

    Entry probes provide useful insights into the structures of planetary atmospheres, but give only one-dimensional pictures of complex four-dimensional systems that vary on all temporal and spatial scales. This makes the interpretation of the results quite challenging, especially as regards atmospheric dynamics. Here is a planetary meteorologist's vision of what the next generation of atmospheric entry probe missions should be: Dedicated sounding instruments get most of the required data from orbit. Relatively simple and inexpensive entry probes are released from the orbiter, with low entry velocities, to establish ground truth, to clarify the vertical structure, and for adaptive observations to enhance the dataset in preparation for sensitive operations. The data are assimilated onboard in real time. The products, being immediately available, are of immense benefit for scientific and operational purposes (aerobraking, aerocapture, accurate payload delivery via glider, ballooning missions, weather forecasts, etc.).

  19. Microstructural Characterization of Next Generation Nuclear Graphites

    Energy Technology Data Exchange (ETDEWEB)

    Karthik Chinnathambi; Joshua Kane; Darryl P. Butt; William E. Windes; Rick Ubic

    2012-04-01

    This article reports the microstructural characteristics of various petroleum and pitch based nuclear graphites (IG-110, NBG-18, and PCEA) that are of interest to the next generation nuclear plant program. Bright-field transmission electron microscopy imaging was used to identify and understand the different features constituting the microstructure of nuclear graphite such as the filler particles, microcracks, binder phase, rosette-shaped quinoline insoluble (QI) particles, chaotic structures, and turbostratic graphite phase. The dimensions of microcracks were found to vary from a few nanometers to tens of microns. Furthermore, the microcracks were found to be filled with amorphous carbon of unknown origin. The pitch coke based graphite (NBG-18) was found to contain higher concentration of binder phase constituting QI particles as well as chaotic structures. The turbostratic graphite, present in all of the grades, was identified through their elliptical diffraction patterns. The difference in the microstructure has been analyzed in view of their processing conditions.

  20. Next generation of energy production systems

    International Nuclear Information System (INIS)

    Rouault, J.; Garnier, J.C.; Carre, F.

    2003-01-01

    This document gathers the slides that have been presented at the Gedepeon conference. Gedepeon is a research group involving scientists from Cea (French atomic energy commission), CNRS (national center of scientific research), EDF (electricity of France) and Framatome that is devoted to the study of new energy sources and particularly to the study of the future generations of nuclear systems. The contributions have been classed into 9 topics: 1) gas cooled reactors, 2) molten salt reactors (MSBR), 3) the recycling of plutonium and americium, 4) reprocessing of molten salt reactor fuels, 5) behavior of graphite under radiation, 6) metallic materials for molten salt reactors, 7) refractory fuels of gas cooled reactors, 8) the nuclear cycle for the next generations of nuclear systems, and 9) organization of research programs on the new energy sources

  1. Astro Data Science: The Next Generation

    Science.gov (United States)

    Mentzel, Chris

    2018-01-01

    Astronomers have been at the forefront of data-driven discovery since before the days of Kepler. Using data in the scientific inquiry into the workings of the the universe is the lifeblood of the field. This said, data science is considered a new thing, and researchers from every discipline are rushing to learn data science techniques, train themselves on data science tools, and even leaving academia to become data scientists. It is undeniable that our ability to harness new computational and statistical methods to make sense of today’s unprecedented size, complexity, and fast streaming data is helping scientists make new discoveries. The question now is how to ensure that researchers can employ these tools and use them appropriately. This talk will cover the state of data science as it relates to scientific research and the role astronomers play in its development, use, and training the next generation of astro-data scientists.

  2. Integrated control of next generation power system

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2010-02-28

    The multi-agent system (MAS) approach has been applied with promising results for enhancing an electric power distribution circuit, such as the Circuit of the Future as developed by Southern California Edison. These next generation power system results include better ability to reconfigure the circuit as well as the increased capability to improve the protection and enhance the reliability of the circuit. There were four main tasks in this project. The specific results for each of these four tasks and their related topics are presented in main sections of this report. Also, there were seven deliverables for this project. The main conclusions for these deliverables are summarized in the identified subtask section of this report. The specific details for each of these deliverables are included in the “Project Deliverables” section at the end of this Final Report.

  3. The Next Generation Transit Survey (NGTS

    Directory of Open Access Journals (Sweden)

    Goad Michael

    2013-04-01

    Full Text Available The Next Generation Transit Survey (NGTS is a new ground-based sky survey designed to find transiting Neptunes and super-Earths. By covering at least sixteen times the sky area of Kepler, we will find small planets around stars that are sufficiently bright for radial velocity confirmation, mass determination and atmospheric characterisation. The NGTS instrument will consist of an array of twelve independently pointed 20 cm telescopes fitted with red-sensitive CCD cameras. It will be constructed at the ESO Paranal Observatory, thereby benefiting from the very best photometric conditions as well as follow up synergy with the VLT and E-ELT. Our design has been verified through the operation of two prototype instruments, demonstrating white noise characteristics to sub-mmag photometric precision. Detailed simulations show that about thirty bright super-Earths and up to two hundred Neptunes could be discovered. Our science operations are due to begin in 2014.

  4. Laser wakefield accelerator based light sources: potential applications and requirements

    Energy Technology Data Exchange (ETDEWEB)

    Albert, F. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). NIF and Photon Sciences; Thomas, A. G. [Univ. of Michigan, Ann Arbor, MI (United States). Dept. of Nuclear Engineering and Radiological Sciences; Mangles, S. P.D. [Imperial College, London (United Kingdom). Blackett Lab.; Banerjee, S. [Univ. of Nebraska, Lincoln, NE (United States); Corde, S. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Flacco, A. [ENSTA, CNRS, Ecole Polytechnique, Palaiseau (France); Litos, M. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Neely, D. [Science and Technology Facilities Council (STFC), Oxford (United Kingdom). Rutherford Appleton Lab. (RAL). Central Laser Facility; Viera, J. [Univ. of Lisbon (Portugal). GoLP-Inst. de Plasmas e Fusao Nuclear-Lab. Associado; Najmudin, Z. [Imperial College, London (United Kingdom). Blackett Lab.; Bingham, R. [Science and Technology Facilities Council (STFC), Oxford (United Kingdom). Rutherford Appleton Lab. (RAL). Central Laser Facility; Joshi, C. [Univ. of California, Los Angeles, CA (United States). Dept. of Electrical Engineering; Katsouleas, T. [Duke Univ., Durham, NC (United States). Platt School of Engineering

    2015-01-15

    In this article we review the prospects of laser wakefield accelerators as next generation light sources for applications. This work arose as a result of discussions held at the 2013 Laser Plasma Accelerators Workshop. X-ray phase contrast imaging, X-ray absorption spectroscopy, and nuclear resonance fluorescence are highlighted as potential applications for laser-plasma based light sources. We discuss ongoing and future efforts to improve the properties of radiation from plasma betatron emission and Compton scattering using laser wakefield accelerators for these specific applications.

  5. Next generation Zero-Code control system UI

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    Developing ergonomic user interfaces for control systems is challenging, especially during machine upgrade and commissioning where several small changes may suddenly be required. Zero-code systems, such as *Inspector*, provide agile features for creating and maintaining control system interfaces. More so, these next generation Zero-code systems bring simplicity and uniformity and brake the boundaries between Users and Developers. In this talk we present *Inspector*, a CERN made Zero-code application development system, and we introduce the major differences and advantages of using Zero-code control systems to develop operational UI.

  6. Mobility Models for Next Generation Wireless Networks Ad Hoc, Vehicular and Mesh Networks

    CERN Document Server

    Santi, Paolo

    2012-01-01

    Mobility Models for Next Generation Wireless Networks: Ad Hoc, Vehicular and Mesh Networks provides the reader with an overview of mobility modelling, encompassing both theoretical and practical aspects related to the challenging mobility modelling task. It also: Provides up-to-date coverage of mobility models for next generation wireless networksOffers an in-depth discussion of the most representative mobility models for major next generation wireless network application scenarios, including WLAN/mesh networks, vehicular networks, wireless sensor networks, and

  7. Cores to Clusters: Star Formation with Next Generation Telescopes

    Science.gov (United States)

    Kumar, M. S. Nanda; Tafalla, M.; Caselli, P.

    2005-11-01

    Towards the second half of this decade several major telescope facilities operating in the infrared submillimeter and millimeter wave bands will become operational. These missions are expected to throw much light on our understanding of the the star formation phenomenon, which is addressed as one of the primary science goals in these wave bands. This book is the proceedings of the "Cores to Clusters" workshop held at Centro de Astrofisica da Universidade do Porto during 7 - 9 October, 2004 to discuss current and future issues in star formation physics in the light of these Next Generation Telescopes. Link: http://www.springeronline.com/sgw/cda/frontpage/0,11855,4-40109-22-51432762-0,00.html

  8. Global Adjoint Tomography: Next-Generation Models

    Science.gov (United States)

    Bozdag, Ebru; Lefebvre, Matthieu; Lei, Wenjie; Orsvuran, Ridvan; Peter, Daniel; Ruan, Youyi; Smith, James; Komatitsch, Dimitri; Tromp, Jeroen

    2017-04-01

    The first-generation global adjoint tomography model GLAD-M15 (Bozdag et al. 2016) is the result of 15 conjugate-gradient iterations based on GPU-accelerated spectral-element simulations of 3D wave propagation and Fréchet kernels. For simplicity, GLAD-M15 was constructed as an elastic model with transverse isotropy confined to the upper mantle. However, Earth's mantle and crust show significant evidence of anisotropy as a result of its composition and deformation. There may be different sources of seismic anisotropy affecting both body and surface waves. As a first attempt, we initially tackle with surface-wave anisotropy and proceed iterations using the same 253 earthquake data set used in GLAD-M15 with an emphasize on upper-mantle. Furthermore, we explore new misfits, such as double-difference measurements (Yuan et al. 2016), to better deal with the possible artifacts of the uneven distribution of seismic stations globally and minimize source uncertainties in structural inversions. We will present our observations with the initial results of azimuthally anisotropic inversions and also discuss the next generation global models with various parametrizations. Meanwhile our goal is to use all available seismic data in imaging. This however requires a solid framework to perform iterative adjoint tomography workflows with big data on supercomputers. We will talk about developments in adjoint tomography workflow from the need of defining new seismic and computational data formats (e.g., ASDF by Krischer et al. 2016, ADIOS by Liu et al. 2011) to developing new pre- and post-processing tools together with experimenting workflow management tools, such as Pegasus (Deelman et al. 2015). All our simulations are performed on Oak Ridge National Laboratory's Cray XK7 "Titan" system. Our ultimate aim is to get ready to harness ORNL's next-generation supercomputer "Summit", an IBM with Power-9 CPUs and NVIDIA Volta GPU accelerators, to be ready by 2018 which will enable us to

  9. Nuclear Knowledge to the Next Generation

    International Nuclear Information System (INIS)

    Mazour, Thomas; Kossilov, Andrei

    2004-01-01

    The safe, reliable, and cost-effective operation of Nuclear Power Plants (NPPs) requires that personnel possess and maintain the requisite knowledge, skills, and attitudes to do their jobs properly. Such knowledge includes not only the technical competencies required by the nature of the technology and particular engineering designs, but also the softer competencies associated with effective management, communication and teamwork. Recent studies have shown that there has been a loss of corporate knowledge and memory. Both explicit knowledge and tacit knowledge must be passed on to the next generation of workers in the industry to ensure a quality workforce. New and different techniques may be required to ensure timely and effective knowledge retention and transfer. The IAEA prepared a report on this subject. The main conclusions from the report regarding strategies for managing the aging workforce are included. Also included are main conclusions from the report regarding the capture an d preservation of mission critical knowledge, and the effective transfer of this knowledge to the next generation of NPP personnel. The nuclear industry due to its need for well-documented procedures, specifications, design basis, safety analyses, etc., has a greater fraction of its mission critical knowledge as explicit knowledge than do many other industries. This facilitates the task of knowledge transfer. For older plants in particular, there may be a need for additional efforts to transfer tacit knowledge to explicit knowledge to support major strategic initiatives such as plant license extensions/renewals, periodic safety reviews, major plant upgrades, and plant specific control room simulator development. The challenge in disseminating explicit knowledge is to make employees aware that it is available and provide easy access in formats and forms that are usable. Tacit knowledge is more difficult to identify and disseminate. The challenge is to identify what can be converted to

  10. Next Generation Nuclear Plant GAP Analysis Report

    Energy Technology Data Exchange (ETDEWEB)

    Ball, Sydney J [ORNL; Burchell, Timothy D [ORNL; Corwin, William R [ORNL; Fisher, Stephen Eugene [ORNL; Forsberg, Charles W. [Massachusetts Institute of Technology (MIT); Morris, Robert Noel [ORNL; Moses, David Lewis [ORNL

    2008-12-01

    As a follow-up to the phenomena identification and ranking table (PIRT) studies conducted recently by NRC on next generation nuclear plant (NGNP) safety, a study was conducted to identify the significant 'gaps' between what is needed and what is already available to adequately assess NGNP safety characteristics. The PIRT studies focused on identifying important phenomena affecting NGNP plant behavior, while the gap study gives more attention to off-normal behavior, uncertainties, and event probabilities under both normal operation and postulated accident conditions. Hence, this process also involved incorporating more detailed evaluations of accident sequences and risk assessments. This study considers thermal-fluid and neutronic behavior under both normal and postulated accident conditions, fission product transport (FPT), high-temperature metals, and graphite behavior and their effects on safety. In addition, safety issues related to coupling process heat (hydrogen production) systems to the reactor are addressed, given the limited design information currently available. Recommendations for further study, including analytical methods development and experimental needs, are presented as appropriate in each of these areas.

  11. Tedizolid Phosphate: a Next-Generation Oxazolidinone.

    Science.gov (United States)

    Rybak, Jeffrey M; Roberts, Karrine

    2015-02-24

    Treatment of multidrug-resistant Gram-positive infections continues to challenge clinicians as the emergence of new resistance mechanisms outpaces introduction of novel antimicrobial agents. Tedizolid phosphate is a next-generation oxazolidinone with activity against both methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus spp. Tedizolid has consistently shown potency advantages over linezolid against Gram-positive microorganisms including those with reduced susceptibility to linezolid. Of particular significance, minimum inhibitory concentrations of tedizolid appear to be largely unaffected by the chloramphenicol-florfenicol resistance (cfr) gene, which has been implicated in a number of published linezolid-resistant organism outbreaks. Tedizolid phosphate also has been found to have a favorable pharmacokinetic profile allowing for once-daily dosing in both oral and intravenous forms. Potency and pharmacokinetic advantages have allowed for lower total daily doses of tedizolid, compared to linezolid, being needed for clinical efficacy in the treatment of acute bacterial skin and skin structure infections (ABSSSI). The decreased total drug exposure produced may in part be responsible for a decrease in the observed adverse effects including thrombocytopenia. Tedizolid phosphate is currently indicated for the treatment of ABSSSI and under investigation for the treatment of nosocomial pneumonia. Although much of the role of tedizolid remains to be defined by expanding clinical experience, tedizolid is likely a welcomed addition to the mere handful of agents available for the treatment of multidrug-resistant Gram-positive infections.

  12. Reaching the Next Generation of Marine Scientists

    Science.gov (United States)

    Joyce, J.

    2009-04-01

    The next generation of marine scientists are today at primary school, secondary school or at college. To encourage them in their career, and to introduce those who are as yet undecided to the wonders of marine science, the Irish Marine Institute has devised a series of three overlapping outreach programmes to reach children at all three levels. Beginning at primary school, the "Explorers" programme offers a range of resources to teachers to enable them to teach marine-related examples as part of the science or geography modules of the SESE curriculum. These include teacher training, expert visits to schools, the installation and stocking of aquaria, field trips and downloadable lesson plans. For older pupils, the "Follow the Fleet" programme is a web-based education asset that allows users to track individual merchant ships and research vessels across the world, to interact with senior crew members of ships and to learn about their cargoes, the ports they visit and the sea conditions along the way. Finally, the "Integrated Marine Exploration Programme (IMEP)" takes secondary school pupils and university students to sea aboard the Marine Institute's research vessels to give them a taste of life as a marine scientist or to educate them in the practical day-to-day sampling and data processing tasks that make up a marine scientist's job.

  13. Implementing Elementary School Next Generation Science Standards

    Science.gov (United States)

    Kennedy, Katheryn B.

    Implementation of the Next Generation Science Standards requires developing elementary teacher content and pedagogical content knowledge of science and engineering concepts. Teacher preparation for this undertaking appears inadequate with little known about how in-service Mid-Atlantic urban elementary science teachers approach this task. The purpose of this basic qualitative interview study was to explore the research questions related to perceived learning needs of 8 elementary science teachers and 5 of their administrators serving as instructional leaders. Strategies needed for professional growth to support learning and barriers that hamper it at both building and district levels were included. These questions were considered through the lens of Schon's reflective learning and Weick's sensemaking theories. Analysis with provisional and open coding strategies identified informal and formal supports and barriers to teachers' learning. Results indicated that informal supports, primarily internet usage, emerged as most valuable to the teachers' learning. Formal structures, including professional learning communities and grade level meetings, arose as both supportive and restrictive at the building and district levels. Existing formal supports emerged as the least useful because of the dominance of other priorities competing for time and resources. Addressing weaknesses within formal supports through more effective planning in professional development can promote positive change. Improvement to professional development approaches using the internet and increased hands on activities can be integrated into formal supports. Explicit attention to these strategies can strengthen teacher effectiveness bringing positive social change.

  14. Next generation advanced nuclear reactor designs

    International Nuclear Information System (INIS)

    Turgut, M. H.

    2009-01-01

    Growing energy demand by technological developments and the increase of the world population and gradually diminishing energy resources made nuclear power an indispensable option. The renewable energy sources like solar, wind and geothermal may be suited to meet some local needs. Environment friendly nuclear energy which is a suitable solution to large scale demands tends to develop highly economical, advanced next generation reactors by incorporating technological developments and years of operating experience. The enhancement of safety and reliability, facilitation of maintainability, impeccable compatibility with the environment are the goals of the new generation reactors. The protection of the investment and property is considered as well as the protection of the environment and mankind. They became economically attractive compared to fossil-fired units by the use of standard designs, replacing some active systems by passive, reducing construction time and increasing the operation lifetime. The evolutionary designs were introduced at first by ameliorating the conventional plants, than revolutionary systems which are denoted as generation IV were verged to meet future needs. The investigations on the advanced, proliferation resistant fuel cycle technologies were initiated to minimize the radioactive waste burden by using new generation fast reactors and ADS transmuters.

  15. Active optics for next generation space telescopes

    Science.gov (United States)

    Costes, V.; Perret, L.; Laubier, D.; Delvit, J. M.; Imbert, C.; Cadiergues, L.; Faure, C.

    2017-09-01

    High resolution observation systems need bigger and bigger telescopes. The design of such telescopes is a key issue for the whole satellite. In order to improve the imaging resolution with minimum impact on the satellite, a big effort must be made to improve the telescope compactness. Compactness is also important for the agility of the satellite and for the size and cost of the launcher. This paper shows how compact a high resolution telescope can be. A diffraction limited telescope can be less than ten times shorter than its focal length. But the compactness impacts drastically the opto-mechanical sensitivity and the optical performances. Typically, a gain of a factor of 2 leads to a mechanical tolerance budget 6 times more difficult. The need to implement active optics for positioning requirements raises very quickly. Moreover, the capability to compensate shape defaults of the primary mirror is the way to simplify the mirror manufacture, to mitigate the development risks and to minimize the cost. The larger the primary mirror is, the more interesting it is to implement active optics for shape compensations. CNES is preparing next generation of earth observation satellite in the frame of OTOS (Observation de la Terre Optique Super-Résolue; High resolution earth observing optical system). OTOS is a technology program. In particular, optical technological developments and breadboards dedicated to active optics are on-going. The aim is to achieve TRL 5 to TRL6 for these new technologies and to validate the global performances of such an active telescope.

  16. Tailoring next-generation biofuels and their combustion in next-generation engines

    Energy Technology Data Exchange (ETDEWEB)

    Gladden, John Michael [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Wu, Weihua [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Taatjes, Craig A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Scheer, Adam Michael [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Turner, Kevin M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Yu, Eizadora T. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); O' Bryan, Greg [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Powell, Amy Jo [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gao, Connie W. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

    2013-11-01

    Increasing energy costs, the dependence on foreign oil supplies, and environmental concerns have emphasized the need to produce sustainable renewable fuels and chemicals. The strategy for producing next-generation biofuels must include efficient processes for biomass conversion to liquid fuels and the fuels must be compatible with current and future engines. Unfortunately, biofuel development generally takes place without any consideration of combustion characteristics, and combustion scientists typically measure biofuels properties without any feedback to the production design. We seek to optimize the fuel/engine system by bringing combustion performance, specifically for advanced next-generation engines, into the development of novel biosynthetic fuel pathways. Here we report an innovative coupling of combustion chemistry, from fundamentals to engine measurements, to the optimization of fuel production using metabolic engineering. We have established the necessary connections among the fundamental chemistry, engine science, and synthetic biology for fuel production, building a powerful framework for co-development of engines and biofuels.

  17. Next-generation healthcare: a strategic appraisal.

    Science.gov (United States)

    Montague, Terrence

    2009-01-01

    Successful next-generation healthcare must deliver timely access and quality for an aging population, while simultaneously promoting disease prevention and managing costs. The key factors for sustained success are a culture with aligned goals and values; coordinated team care that especially engages with physicians and patients; practical information that is collected and communicated reliably; and education in the theory and methods of collaboration, measurement and leadership. Currently, optimal population health is challenged by a high prevalence of chronic disease, with large gaps between best and usual care, a scarcity of health human resources - particularly with the skills, attitudes and training for coordinated team care - and the absence of flexible, reliable clinical measurement systems. However, to make things better, institutional models and supporting technologies are available. In the short term, a first step is to enhance the awareness of the practical opportunities to improve, including the expansion of proven community-based disease management programs that communicate knowledge, competencies and clinical measurements among professional and patient partners, leading to reduced care gaps and improved clinical and economic outcomes. Longer-term success requires two additional steps. One is formal inter-professional training to provide, on an ongoing basis, the polyvalent human resource skills and foster the culture of working with others to improve the care of whole populations. The other is the adoption of reliable information systems, including electronic health records, to allow useful and timely measurement and effective communication of clinical information in real-world settings. A better health future can commence immediately, within existing resources, and be sustained with feasible innovations in provider and patient education and information systems. The future is now.

  18. Engineered CRISPR Systems for Next Generation Gene Therapies.

    Science.gov (United States)

    Pineda, Michael; Moghadam, Farzaneh; Ebrahimkhani, Mo R; Kiani, Samira

    2017-09-15

    An ideal in vivo gene therapy platform provides safe, reprogrammable, and precise strategies which modulate cell and tissue gene regulatory networks with a high temporal and spatial resolution. Clustered regularly interspaced short palindromic repeats (CRISPR), a bacterial adoptive immune system, and its CRISPR-associated protein 9 (Cas9), have gained attention for the ability to target and modify DNA sequences on demand with unprecedented flexibility and precision. The precision and programmability of Cas9 is derived from its complexation with a guide-RNA (gRNA) that is complementary to a desired genomic sequence. CRISPR systems open-up widespread applications including genetic disease modeling, functional screens, and synthetic gene regulation. The plausibility of in vivo genetic engineering using CRISPR has garnered significant traction as a next generation in vivo therapeutic. However, there are hurdles that need to be addressed before CRISPR-based strategies are fully implemented. Some key issues center on the controllability of the CRISPR platform, including minimizing genomic-off target effects and maximizing in vivo gene editing efficiency, in vivo cellular delivery, and spatial-temporal regulation. The modifiable components of CRISPR systems: Cas9 protein, gRNA, delivery platform, and the form of CRISPR system delivered (DNA, RNA, or ribonucleoprotein) have recently been engineered independently to design a better genome engineering toolbox. This review focuses on evaluating CRISPR potential as a next generation in vivo gene therapy platform and discusses bioengineering advancements that can address challenges associated with clinical translation of this emerging technology.

  19. Next generation LP system for maintenance in nuclear power reactors

    International Nuclear Information System (INIS)

    Mukai, Naruhiko; Uehara, Takuya; Suezono, Nobuichi; Saeki, Ryoichi; Sano, Yuji

    2006-01-01

    Laser peening (LP) is a process to introduce residual compressive stress on metal surface by irradiating laser pulses underwater without any surface preparations. Toshiba has developed and applied LP system to preventive maintenance against stress corrosion cracking (SCC) in nuclear power reactors since 1999. The system is composed of laser oscillators, a beam delivery system, a laser irradiation head, remote handling equipment and a monitor/control system. In the early applications, a rigidly laser beam delivery system with many mirrors and beam guide pipes was accomplished. A flexible fiber-delivery system has been developed for accessing to the narrow place, and presently it is adopted mainly. As these beam-delivery systems require a wide installation space and difficult operation, a simple and small system is desired. In order to meet this demand, we are developing the small-sized next generation LP system that builds in the laser oscillator inside the remote handling equipment. In the next generation system new irradiating method is adopted, stress improvement speed is faster than the present system. (author)

  20. Optical Property Evaluation of Next Generation Thermal Control Coatings

    Science.gov (United States)

    Jaworske, Donald A.; Deshpande, Mukund S.; Pierson, Edward A.

    2010-01-01

    Next generation white thermal control coatings were developed via the Small Business Innovative Research program utilizing lithium silicate chemistry as a binder. Doping of the binder with additives yielded a powder that was plasma spray capable and that could be applied to light weight polymers and carbon-carbon composite surfaces. The plasma sprayed coating had acceptable beginning-of-life and end-of-live optical properties, as indicated by a successful 1.5 year exposure to the space environment in low Earth orbit. Recent studies also showed the coating to be durable to simulated space environments consisting of 1 keV and 10 keV electrons, 4.5 MeV electrons, and thermal cycling. Large scale deposition was demonstrated on a polymer matrix composite radiator panel, leading to the selection of the coating for use on the Gravity Recovery And Interior Laboratory (GRAIL) mission.

  1. Next Generation Nuclear Plant Resilient Control System Functional Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Lynne M. Stevens

    2010-07-01

    Control Systems and their associated instrumentation must meet reliability, availability, maintainability, and resiliency criteria in order for high temperature gas-cooled reactors (HTGRs) to be economically competitive. Research, perhaps requiring several years, may be needed to develop control systems to support plant availability and resiliency. This report functionally analyzes the gaps between traditional and resilient control systems as applicable to HTGRs, which includes the Next Generation Nuclear Plant; defines resilient controls; assesses the current state of both traditional and resilient control systems; and documents the functional gaps existing between these two controls approaches as applicable to HTGRs. This report supports the development of an overall strategy for applying resilient controls to HTGRs by showing that control systems with adequate levels of resilience perform at higher levels, respond more quickly to disturbances, increase operational efficiency, and increase public protection.

  2. Performance analysis of next-generation lunar laser retroreflectors

    Science.gov (United States)

    Ciocci, Emanuele; Martini, Manuele; Contessa, Stefania; Porcelli, Luca; Mastrofini, Marco; Currie, Douglas; Delle Monache, Giovanni; Dell'Agnello, Simone

    2017-09-01

    Starting from 1969, Lunar Laser Ranging (LLR) to the Apollo and Lunokhod Cube Corner Retroreflectors (CCRs) provided several tests of General Relativity (GR). When deployed, the Apollo/Lunokhod CCRs design contributed only a negligible fraction of the ranging error budget. Today the improvement over the years in the laser ground stations makes the lunar libration contribution relevant. So the libration now dominates the error budget limiting the precision of the experimental tests of gravitational theories. The MoonLIGHT-2 project (Moon Laser Instrumentation for General relativity High-accuracy Tests - Phase 2) is a next-generation LLR payload developed by the Satellite/lunar/GNSS laser ranging/altimetry and Cube/microsat Characterization Facilities Laboratory (SCF _ Lab) at the INFN-LNF in collaboration with the University of Maryland. With its unique design consisting of a single large CCR unaffected by librations, MoonLIGHT-2 can significantly reduce error contribution of the reflectors to the measurement of the lunar geodetic precession and other GR tests compared to Apollo/Lunokhod CCRs. This paper treats only this specific next-generation lunar laser retroreflector (MoonLIGHT-2) and it is by no means intended to address other contributions to the global LLR error budget. MoonLIGHT-2 is approved to be launched with the Moon Express 1(MEX-1) mission and will be deployed on the Moon surface in 2018. To validate/optimize MoonLIGHT-2, the SCF _ Lab is carrying out a unique experimental test called SCF-Test: the concurrent measurement of the optical Far Field Diffraction Pattern (FFDP) and the temperature distribution of the CCR under thermal conditions produced with a close-match solar simulator and simulated space environment. The focus of this paper is to describe the SCF _ Lab specialized characterization of the performance of our next-generation LLR payload. While this payload will improve the contribution of the error budget of the space segment (MoonLIGHT-2

  3. Next-generation probabilistic seismicity forecasting

    Energy Technology Data Exchange (ETDEWEB)

    Hiemer, S.

    2014-07-01

    novel automated method to investigate the significance of spatial b-value variations. The method incorporates an objective data-driven partitioning scheme, which is based on penalized likelihood estimates. These well-defined criteria avoid the difficult choice of commonly applied spatial mapping parameters, such as grid spacing or size of mapping radii. We construct a seismicity forecast that includes spatial b-value variations and demonstrate our model’s skill and reliability when applied to data from California. All proposed probabilistic seismicity forecasts were subjected to evaluation methods using state of the art algorithms provided by the 'Collaboratory for the Study of Earthquake Predictability' infrastructure. First, we evaluated the statistical agreement between the forecasted and observed rates of target events in terms of number, space and magnitude. Secondly, we assessed the performance of one forecast relative to another. We find that the forecasts presented in this thesis are reliable and show significant skills with respect to established classical forecasts. These next-generation probabilistic seismicity forecasts can thus provide hazard information that are potentially useful in reducing earthquake losses and enhancing community preparedness and resilience. (author)

  4. Next-generation probabilistic seismicity forecasting

    International Nuclear Information System (INIS)

    Hiemer, S.

    2014-01-01

    novel automated method to investigate the significance of spatial b-value variations. The method incorporates an objective data-driven partitioning scheme, which is based on penalized likelihood estimates. These well-defined criteria avoid the difficult choice of commonly applied spatial mapping parameters, such as grid spacing or size of mapping radii. We construct a seismicity forecast that includes spatial b-value variations and demonstrate our model’s skill and reliability when applied to data from California. All proposed probabilistic seismicity forecasts were subjected to evaluation methods using state of the art algorithms provided by the 'Collaboratory for the Study of Earthquake Predictability' infrastructure. First, we evaluated the statistical agreement between the forecasted and observed rates of target events in terms of number, space and magnitude. Secondly, we assessed the performance of one forecast relative to another. We find that the forecasts presented in this thesis are reliable and show significant skills with respect to established classical forecasts. These next-generation probabilistic seismicity forecasts can thus provide hazard information that are potentially useful in reducing earthquake losses and enhancing community preparedness and resilience. (author)

  5. Novel gratings for next-generation instruments of astronomical observations

    Science.gov (United States)

    Ebizuka, N.; Okamoto, T.; Takeda, M.; Hosobata, T.; Yamagata, Y.; Sasaki, M.; Uomoto, M.; Shimatsu, T.; Sato, S.; Hashimoto, N.; Tanaka, I.; Hattori, T.; Ozaki, S.; Aoki, W.

    2017-05-01

    We will introduce current status of development of a birefringence volume phase holographic (B-VPH) grating, volume binary (VB) grating and reflector facet transmission (RFT) grating developing as the novel dispersive optical element for astronomical instruments for the 8.2m Subaru Telescope, for next generation 30 m class huge ground-based telescopes and for next generation large space-bone telescopes. We will also introduce a hybrid grism developed for MOIRCS (Multi-Object InfraRed Camera and Spectrograph) of the Subaru Telescope and a quasi-Bragg (QB) immersion grating. Test fabrication of B-VPH gratings with a liquid crystal (LC) of UV curable and normal LCs or a resin of visible light curable are performed. We successfully fabricated VB gratings of silicon as a mold with ridges of a high aspect ratio by means of the cycle etching process, oxidation and removal of silicon oxide. The RFT grating which is a surface-relief (SR) transmission grating with sawtooth shaped ridges of an acute vertex angle. The hybrid grism, as a prototype of the RFT grating, combines a high-index prism and SR transmission grating with sawtooth shape ridges of an acute vertex angle. The mold of the SR grating for the hybrid grism on to a work of Ni-P alloy of non-electrolysic plating successfully fabricated by using our ultra-precision machine and a single-crystal diamond bite. The QB immersion grating was fabricated by a combination of an inclined QB grating, Littrow prism and surface reflection mirror.

  6. Structural materials for the next generation of technologies

    CERN Document Server

    Van de Voorde, Marcel Hubert

    1996-01-01

    1. Overview of advanced technologies; i.e. aerospace-aeronautics; automobile; energy technology; accelerator engineering etc. and the need for new structural materials. 2. Familiarisation with polymers, metals and alloys, structural ceramics, composites and surface engineering. The study of modern materials processing, generation of a materials data base, engineering properties includind NDE, radiation damage etc. 3. Development of new materials for the next generation of technologies; including the spin-off of materials developed for space and military purposes to industrial applications. 4. Materials selection for modern accelerator engineering. 5. Materials research in Europe, USA and Japan. Material R & D programmes sponsored by the European Union and the collaboration of CERN in EU sponsored programmes.

  7. Neurogenetics: advancing the "next-generation" of brain research.

    Science.gov (United States)

    Zoghbi, Huda Y; Warren, Stephen T

    2010-10-21

    There can be little doubt that genetics has transformed our understanding of mechanisms mediating brain disorders. The last two decades have brought tremendous progress in terms of accurate molecular diagnoses and knowledge of the genes and pathways that are involved in a large number of neurological and psychiatric disorders. Likewise, new methods and analytical approaches, including genome array studies and "next-generation" sequencing technologies, are bringing us deeper insights into the subtle complexities of the genetic architecture that determines our risks for these disorders. As we now seek to translate these discoveries back to clinical applications, a major challenge for the field will be in bridging the gap between genes and biology. In this Overview of Neuron's special review issue on neurogenetics, we reflect on progress made over the last two decades and highlight the challenges as well as the exciting opportunities for the future. Copyright © 2010 Elsevier Inc. All rights reserved.

  8. Advanced Material Strategies for Next-Generation Additive Manufacturing

    Science.gov (United States)

    Chang, Jinke; He, Jiankang; Zhou, Wenxing; Lei, Qi; Li, Xiao; Li, Dichen

    2018-01-01

    Additive manufacturing (AM) has drawn tremendous attention in various fields. In recent years, great efforts have been made to develop novel additive manufacturing processes such as micro-/nano-scale 3D printing, bioprinting, and 4D printing for the fabrication of complex 3D structures with high resolution, living components, and multimaterials. The development of advanced functional materials is important for the implementation of these novel additive manufacturing processes. Here, a state-of-the-art review on advanced material strategies for novel additive manufacturing processes is provided, mainly including conductive materials, biomaterials, and smart materials. The advantages, limitations, and future perspectives of these materials for additive manufacturing are discussed. It is believed that the innovations of material strategies in parallel with the evolution of additive manufacturing processes will provide numerous possibilities for the fabrication of complex smart constructs with multiple functions, which will significantly widen the application fields of next-generation additive manufacturing. PMID:29361754

  9. Advanced Material Strategies for Next-Generation Additive Manufacturing.

    Science.gov (United States)

    Chang, Jinke; He, Jiankang; Mao, Mao; Zhou, Wenxing; Lei, Qi; Li, Xiao; Li, Dichen; Chua, Chee-Kai; Zhao, Xin

    2018-01-22

    Additive manufacturing (AM) has drawn tremendous attention in various fields. In recent years, great efforts have been made to develop novel additive manufacturing processes such as micro-/nano-scale 3D printing, bioprinting, and 4D printing for the fabrication of complex 3D structures with high resolution, living components, and multimaterials. The development of advanced functional materials is important for the implementation of these novel additive manufacturing processes. Here, a state-of-the-art review on advanced material strategies for novel additive manufacturing processes is provided, mainly including conductive materials, biomaterials, and smart materials. The advantages, limitations, and future perspectives of these materials for additive manufacturing are discussed. It is believed that the innovations of material strategies in parallel with the evolution of additive manufacturing processes will provide numerous possibilities for the fabrication of complex smart constructs with multiple functions, which will significantly widen the application fields of next-generation additive manufacturing.

  10. Power Electronics for the Next Generation Wind Turbine System

    DEFF Research Database (Denmark)

    Ma, Ke

    The wind power generation has been steadily growing both for the total installed capacity and for the individual turbine size. Due to much more significant impacts to the power grid, the power electronics, which can change the behavior of wind turbines from an unregulated power source to an active...... generation unit, are becoming crucial in the wind turbine system. The objective of this project is to study the power electronics technology used for the next generation wind turbines. Some emerging challenges as well as potentials like the cost of energy and reliability are going to be addressed. First...... several potential converter topologies and power semiconductor devices for the future wind power application are presented in respect to the advantages/drawbacks. And then the criteria for evaluating the wind power converter are generally discussed, where the importance of thermal stress in the power...

  11. Control of Next Generation Aircraft and Wind Turbines

    Science.gov (United States)

    Frost, Susan

    2010-01-01

    The first part of this talk will describe some of the exciting new next generation aircraft that NASA is proposing for the future. These aircraft are being designed to reduce aircraft fuel consumption and environmental impact. Reducing the aircraft weight is one approach that will be used to achieve these goals. A new control framework will be presented that enables lighter, more flexible aircraft to maintain aircraft handling qualities, while preventing the aircraft from exceeding structural load limits. The second part of the talk will give an overview of utility-scale wind turbines and their control. Results of collaboration with Dr. Balas will be presented, including new theory to adaptively control the turbine in the presence of structural modes, with the focus on the application of this theory to a high-fidelity simulation of a wind turbine.

  12. Advanced Material Strategies for Next-Generation Additive Manufacturing

    Directory of Open Access Journals (Sweden)

    Jinke Chang

    2018-01-01

    Full Text Available Additive manufacturing (AM has drawn tremendous attention in various fields. In recent years, great efforts have been made to develop novel additive manufacturing processes such as micro-/nano-scale 3D printing, bioprinting, and 4D printing for the fabrication of complex 3D structures with high resolution, living components, and multimaterials. The development of advanced functional materials is important for the implementation of these novel additive manufacturing processes. Here, a state-of-the-art review on advanced material strategies for novel additive manufacturing processes is provided, mainly including conductive materials, biomaterials, and smart materials. The advantages, limitations, and future perspectives of these materials for additive manufacturing are discussed. It is believed that the innovations of material strategies in parallel with the evolution of additive manufacturing processes will provide numerous possibilities for the fabrication of complex smart constructs with multiple functions, which will significantly widen the application fields of next-generation additive manufacturing.

  13. Deep learning—Accelerating Next Generation Performance Analysis Systems?

    Directory of Open Access Journals (Sweden)

    Heike Brock

    2018-02-01

    Full Text Available Deep neural network architectures show superior performance in recognition and prediction tasks of the image, speech and natural language domains. The success of such multi-layered networks encourages their implementation in further application scenarios as the retrieval of relevant motion information for performance enhancement in sports. However, to date deep learning is only seldom applied to activity recognition problems of the human motion domain. Therefore, its use for sports data analysis might remain abstract to many practitioners. This paper provides a survey on recent works in the field of high-performance motion data and examines relevant technologies for subsequent deployment in real training systems. In particular, it discusses aspects of data acquisition, processing and network modeling. Analysis suggests the advantage of deep neural networks under difficult and noisy data conditions. However, further research is necessary to confirm the benefit of deep learning for next generation performance analysis systems.

  14. Using Evidence to Create Next Generation High Schools

    Science.gov (United States)

    Office of Planning, Evaluation and Policy Development, US Department of Education, 2016

    2016-01-01

    Next Generation High Schools are schools that redesign the high school experience to make it more engaging and worthwhile for high school students. In order to create such Next Generation High Schools, schools, districts, and States should utilize evidence-based strategies to transform high schools in ways that engage students and help prepare…

  15. The next-generation ARC middleware

    DEFF Research Database (Denmark)

    Appleton, O.; Cameron, D.; Cernak, J.

    2010-01-01

    The Advanced Resource Connector (ARC) is a light-weight, non-intrusive, simple yet powerful Grid middleware capable of connecting highly heterogeneous computing and storage resources. ARC aims at providing general purpose, flexible, collaborative computing environments suitable for a range of uses...

  16. Graphene Transparent Conductive Electrodes for Next- Generation Microshutter Arrays

    Science.gov (United States)

    Li, Mary; Sultana, Mahmooda; Hess, Larry

    2012-01-01

    Graphene is a single atomic layer of graphite. It is optically transparent and has high electron mobility, and thus has great potential to make transparent conductive electrodes. This invention contributes towards the development of graphene transparent conductive electrodes for next-generation microshutter arrays. The original design for the electrodes of the next generation of microshutters uses indium-tin-oxide (ITO) as the electrode material. ITO is widely used in NASA flight missions. The optical transparency of ITO is limited, and the material is brittle. Also, ITO has been getting more expensive in recent years. The objective of the invention is to develop a graphene transparent conductive electrode that will replace ITO. An exfoliation procedure was developed to make graphene out of graphite crystals. In addition, large areas of single-layer graphene were produced using low-pressure chemical vapor deposition (LPCVD) with high optical transparency. A special graphene transport procedure was developed for transferring graphene from copper substrates to arbitrary substrates. The concept is to grow large-size graphene sheets using the LPCVD system through chemical reaction, transfer the graphene film to a substrate, dope graphene to reduce the sheet resistance, and pattern the film to the dimension of the electrodes in the microshutter array. Graphene transparent conductive electrodes are expected to have a transparency of 97.7%. This covers the electromagnetic spectrum from UV to IR. In comparison, ITO electrodes currently used in microshutter arrays have 85% transparency in mid-IR, and suffer from dramatic transparency drop at a wavelength of near-IR or shorter. Thus, graphene also has potential application as transparent conductive electrodes for Schottky photodiodes in the UV region.

  17. 78 FR 64404 - Next Generation 911; Text-to-911; Next Generation 911 Applications

    Science.gov (United States)

    2013-10-29

    ... the consumer's location supports text-to-911. Thus, Blooston argues that the bounce-back rule should... consumer is located in an area where the local PSAP accepts text-to-911. APCO contends that if a roaming consumer is in an area where the PSAP supports text-to-911, the home and host providers should be required...

  18. 78 FR 1799 - Next Generation 911; Text-to-911; Next Generation 911 Applications

    Science.gov (United States)

    2013-01-09

    ... goal of launching text-to-911 nationwide in 2013. In addition, the Alliance for Telecommunications Industry Solutions (ATIS), an organization consisting of a large number of wireless and wireline carriers... PSAP and industry communities about the timing of SMS text-to-9-1-1, but so long as the most common...

  19. Creating the next generation control system software

    International Nuclear Information System (INIS)

    Schultz, D.E.

    1989-01-01

    A new 1980's style support package for future accelerator control systems is proposed. It provides a way to create accelerator applications software without traditional programming. Visual Interactive Applications (VIA) is designed to meet the needs of expanded accelerator complexes in a more cost effective way than past experience with procedural languages by using technology from the personal computer and artificial intelligence communities. 4 refs

  20. Next Generation Model 8800 Automatic TLD Reader

    International Nuclear Information System (INIS)

    Velbeck, K.J.; Streetz, K.L.; Rotunda, J.E.

    1999-01-01

    BICRON NE has developed an advanced version of the Model 8800 Automatic TLD Reader. Improvements in the reader include a Windows NT TM -based operating system and a Pentium microprocessor for the host controller, a servo-controlled transport, a VGA display, mouse control, and modular assembly. This high capacity reader will automatically read fourteen hundred TLD Cards in one loading. Up to four elements in a card can be heated without mechanical contact, using hot nitrogen gas. Improvements in performance include an increased throughput rate and more precise card positioning. Operation is simplified through easy-to-read Windows-type screens. Glow curves are displayed graphically along with light intensity, temperature, and channel scaling. Maintenance and diagnostic aids are included for easier troubleshooting. A click of a mouse will command actions that are displayed in easy-to-understand English words. Available options include an internal 90 Sr irradiator, automatic TLD calibration, and two different extremity monitoring modes. Results from testing include reproducibility, reader stability, linearity, detection threshold, residue, primary power supply voltage and frequency, transient voltage, drop testing, and light leakage. (author)

  1. Building next-generation converged networks theory and practice

    CERN Document Server

    Pathan, Al-Sakib Khan

    2013-01-01

    Supplying a comprehensive introduction to next-generation networks, Building Next-Generation Converged Networks: Theory and Practice strikes a balance between how and why things work and how to make them work. It compiles recent advancements along with basic issues from the wide range of fields related to next generation networks. Containing the contributions of 56 industry experts and researchers from 16 different countries, the book presents relevant theoretical frameworks and the latest research. It investigates new technologies such as IPv6 over Low Power Wireless Personal Area Network (6L

  2. Educating the next generation of customs professionals

    NARCIS (Netherlands)

    Heijmann, F.; Lutterop, M; Tan, Y.H.; Giesbers, B; Zuidwijk, RA; Hulstijn, J.

    2015-01-01

    Are there ways to improve compliance, safety, security,
    operational efficiency and information quality in
    international trade? Reduce the administrative burden
    for business and government? Foster the uniform
    application of Customs legislation? Encourage mutual
    understanding

  3. ADEPT2 - Next Generation Process Management Technology

    NARCIS (Netherlands)

    Dadam, P.; Rinderle, S.B.; Reichert, M.U.; Jurisch, M.; Acker, H.; Göser, K.; Kreher, U; Lauer, M.

    If current process management systems shall be applied to a broad spectrum of applications, they will have to be significantly improved with respect to their technological capabilities. In particular, in dynamic environments it must be possible to quickly implement and deploy new processes, to

  4. Japan's robotics research for the next generation

    Science.gov (United States)

    Umetani, Y.; Yonemoto, K.

    1983-10-01

    The results of a survey of Japanese research institutes concerning the direction of Japanese robotics development over the next twenty years are presented. Attention is given to an assessment of the goals of robotics R & D in the public and private sectors based on the total research budgets of R & D institutes, the number of research laboratories studying robotics, and the various classifications of the topics of study. The study topics include work, control, measurement and recognition functions. A time table is presented which lists the specific applications of robotic research, the year of their expected actualization, and the degree of importance assigned by the respondents. Some of the more important applications are: robots able to work in hostile environments; robots for unmanned mining operations; and the rationalization of such tasks as afforestation, felling and transport activities in steep forested land through the use of advanced locomotive technology.

  5. Infrared Spectroscopic Imaging: The Next Generation

    Science.gov (United States)

    Bhargava, Rohit

    2013-01-01

    Infrared (IR) spectroscopic imaging seemingly matured as a technology in the mid-2000s, with commercially successful instrumentation and reports in numerous applications. Recent developments, however, have transformed our understanding of the recorded data, provided capability for new instrumentation, and greatly enhanced the ability to extract more useful information in less time. These developments are summarized here in three broad areas— data recording, interpretation of recorded data, and information extraction—and their critical review is employed to project emerging trends. Overall, the convergence of selected components from hardware, theory, algorithms, and applications is one trend. Instead of similar, general-purpose instrumentation, another trend is likely to be diverse and application-targeted designs of instrumentation driven by emerging component technologies. The recent renaissance in both fundamental science and instrumentation will likely spur investigations at the confluence of conventional spectroscopic analyses and optical physics for improved data interpretation. While chemometrics has dominated data processing, a trend will likely lie in the development of signal processing algorithms to optimally extract spectral and spatial information prior to conventional chemometric analyses. Finally, the sum of these recent advances is likely to provide unprecedented capability in measurement and scientific insight, which will present new opportunities for the applied spectroscopist. PMID:23031693

  6. Towards next generation 3D cameras

    Science.gov (United States)

    Gupta, Mohit

    2017-03-01

    We are in the midst of a 3D revolution. Robots enabled by 3D cameras are beginning to autonomously drive cars, perform surgeries, and manage factories. However, when deployed in the real-world, these cameras face several challenges that prevent them from measuring 3D shape reliably. These challenges include large lighting variations (bright sunlight to dark night), presence of scattering media (fog, body tissue), and optically complex materials (metal, plastic). Due to these factors, 3D imaging is often the bottleneck in widespread adoption of several key robotics technologies. I will talk about our work on developing 3D cameras based on time-of-flight and active triangulation that addresses these long-standing problems. This includes designing `all-weather' cameras that can perform high-speed 3D scanning in harsh outdoor environments, as well as cameras that recover shape of objects with challenging material properties. These cameras are, for the first time, capable of measuring detailed (<100 microns resolution) scans in extremely demanding scenarios with low-cost components. Several of these cameras are making a practical impact in industrial automation, being adopted in robotic inspection and assembly systems.

  7. The impact of next-generation sequencing on genomics.

    Science.gov (United States)

    Zhang, Jun; Chiodini, Rod; Badr, Ahmed; Zhang, Genfa

    2011-03-20

    This article reviews basic concepts, general applications, and the potential impact of next-generation sequencing (NGS) technologies on genomics, with particular reference to currently available and possible future platforms and bioinformatics. NGS technologies have demonstrated the capacity to sequence DNA at unprecedented speed, thereby enabling previously unimaginable scientific achievements and novel biological applications. But, the massive data produced by NGS also presents a significant challenge for data storage, analyses, and management solutions. Advanced bioinformatic tools are essential for the successful application of NGS technology. As evidenced throughout this review, NGS technologies will have a striking impact on genomic research and the entire biological field. With its ability to tackle the unsolved challenges unconquered by previous genomic technologies, NGS is likely to unravel the complexity of the human genome in terms of genetic variations, some of which may be confined to susceptible loci for some common human conditions. The impact of NGS technologies on genomics will be far reaching and likely change the field for years to come. Copyright © 2011. Published by Elsevier Ltd.

  8. Next generation tools for genomic data generation, distribution, and visualization

    Directory of Open Access Journals (Sweden)

    Nix David A

    2010-09-01

    Full Text Available Abstract Background With the rapidly falling cost and availability of high throughput sequencing and microarray technologies, the bottleneck for effectively using genomic analysis in the laboratory and clinic is shifting to one of effectively managing, analyzing, and sharing genomic data. Results Here we present three open-source, platform independent, software tools for generating, analyzing, distributing, and visualizing genomic data. These include a next generation sequencing/microarray LIMS and analysis project center (GNomEx; an application for annotating and programmatically distributing genomic data using the community vetted DAS/2 data exchange protocol (GenoPub; and a standalone Java Swing application (GWrap that makes cutting edge command line analysis tools available to those who prefer graphical user interfaces. Both GNomEx and GenoPub use the rich client Flex/Flash web browser interface to interact with Java classes and a relational database on a remote server. Both employ a public-private user-group security model enabling controlled distribution of patient and unpublished data alongside public resources. As such, they function as genomic data repositories that can be accessed manually or programmatically through DAS/2-enabled client applications such as the Integrated Genome Browser. Conclusions These tools have gained wide use in our core facilities, research laboratories and clinics and are freely available for non-profit use. See http://sourceforge.net/projects/gnomex/, http://sourceforge.net/projects/genoviz/, and http://sourceforge.net/projects/useq.

  9. Next generation tools for genomic data generation, distribution, and visualization.

    Science.gov (United States)

    Nix, David A; Di Sera, Tonya L; Dalley, Brian K; Milash, Brett A; Cundick, Robert M; Quinn, Kevin S; Courdy, Samir J

    2010-09-09

    With the rapidly falling cost and availability of high throughput sequencing and microarray technologies, the bottleneck for effectively using genomic analysis in the laboratory and clinic is shifting to one of effectively managing, analyzing, and sharing genomic data. Here we present three open-source, platform independent, software tools for generating, analyzing, distributing, and visualizing genomic data. These include a next generation sequencing/microarray LIMS and analysis project center (GNomEx); an application for annotating and programmatically distributing genomic data using the community vetted DAS/2 data exchange protocol (GenoPub); and a standalone Java Swing application (GWrap) that makes cutting edge command line analysis tools available to those who prefer graphical user interfaces. Both GNomEx and GenoPub use the rich client Flex/Flash web browser interface to interact with Java classes and a relational database on a remote server. Both employ a public-private user-group security model enabling controlled distribution of patient and unpublished data alongside public resources. As such, they function as genomic data repositories that can be accessed manually or programmatically through DAS/2-enabled client applications such as the Integrated Genome Browser. These tools have gained wide use in our core facilities, research laboratories and clinics and are freely available for non-profit use. See http://sourceforge.net/projects/gnomex/, http://sourceforge.net/projects/genoviz/, and http://sourceforge.net/projects/useq.

  10. Next-generation commercial spaceborne systems

    Science.gov (United States)

    Stavitsky, David; Blasberger, Avigdor

    2001-12-01

    Commercial satellite remote sensing is a rapidly growing market, some projections indicating revenues from the sale of data and GIS products totaling over 12B by 2003. Though commercial remote sensing may be promising, there have been some limiters to the growth of the market over the past few years, including the costs per image, the not-so-timely acquisition of data and delivery to the customer, and others. One current inhibitor to the growth of the market is the cost of commercial images. Most commercially provided data range from 1,500 to 4,000 per scene, depending on the resolution and size of the image, with more integrated GIS products costing as high as 10,000 for one image. A second inhibitor is the difficulty in translating spectral signatures into useful and accurate information without weeks of ground research. Another potential inhibitor is the timeliness in acquiring satellite images. At present, it takes anywhere from two days to well over four weeks before customers receive imagery from vendors. This time lapse can be a problem for users of imagery with rigid time constraints (e.g., agricultural or media interests). Due to these inhibitors, the success of a remote sensing system depends not just on the spectrum and resolution of the data, but also on other factors important to customers such as image cost, speedy access to data, service reliability, and other figures of merit relevant to a customers needs. ELOP has examined how these various figures of merit become beneficial to different applications as they vary in performance. Applications such as Agriculture, Forestry, Geology, Coastal & Water and many other, were compared with variations in spatial resolution, spectral resolution, spectral range, revisit rate, data delivery speed, and others. A condensed version for varying figures of merit evaluated with some expected applications will be presented and the various parameters analyzed for variable revisit rate with a conclusive approach for the

  11. Penetration tests in next generation networks

    Science.gov (United States)

    Rezac, Filip; Voznak, Miroslav

    2012-06-01

    SIP proxy server is without any doubts centerpiece of any SIP IP telephony infrastructure. It also often provides other services than those related to VoIP traffic. These softswitches are, however, very often become victims of attacks and threats coming from public networks. The paper deals with a system that we developed as an analysis and testing tool to verify if the target SIP server is adequately secured and protected against any real threats. The system is designed as an open-source application, thus allowing independent access and is fully extensible to other test modules.

  12. The Next Generation BioPhotonics Workstation

    DEFF Research Database (Denmark)

    Bañas, Andrew Rafael

    in supporting these biological studies. We study use of a novel and robust beam shaping technique, i.e. the matched filtering Generalized Phase Contrast method, and other ways of improving the trapping stability in the BWS, such as using machine vision based feedback. We also present our work on microtools...... and applications of the BWS such as using Generalized Phase Contrast to increase its efficiency, imaging cells while external stressors, such as heat are introduced, and adapting the BWS to replace existing bulky and expensive cell sorting systems....

  13. Next-Generation Web Frameworks in Python

    CERN Document Server

    Daly, Liza

    2007-01-01

    With its flexibility, readability, and maturecode libraries, Python is a naturalchoice for developing agile and maintainableweb applications. Severalframeworks have emerged in the last fewyears that share ideas with Ruby on Railsand leverage the expressive nature of Python.This Short Cut will tell you whatyou need to know about the hottest fullstackframeworks: Django, Pylons, andTurboGears. Their philosophies, relativestrengths, and development status aredescribed in detail. What you won't find out is, "Which oneshould I use?" The short answer is thatall of them can be used to build web appl

  14. Next Generation Life Support (NGLS): Rapid Cycle Amine Swing Bed

    Data.gov (United States)

    National Aeronautics and Space Administration — The Rapid Cycle Amine (RCA) swingbed has been identified as a technology with high potential to meet the stringent requirements for the next generation spacesuit's...

  15. NIH Abroad: Inspiring the Next Generation of Global Health Researchers

    Science.gov (United States)

    ... Home Current Issue Past Issues Special Section NIH Abroad: Inspiring the Next Generation of Global Health Researchers ... interaction has always been important to me, but working with these patients in Zambia lit a fire ...

  16. Pharmacokinetic and pharmacodynamic considerations for the next generation protein therapeutics.

    Science.gov (United States)

    Shah, Dhaval K

    2015-10-01

    Increasingly sophisticated protein engineering efforts have been undertaken lately to generate protein therapeutics with desired properties. This has resulted in the discovery of the next generation of protein therapeutics, which include: engineered antibodies, immunoconjugates, bi/multi-specific proteins, antibody mimetic novel scaffolds, and engineered ligands/receptors. These novel protein therapeutics possess unique physicochemical properties and act via a unique mechanism-of-action, which collectively makes their pharmacokinetics (PK) and pharmacodynamics (PD) different than other established biological molecules. Consequently, in order to support the discovery and development of these next generation molecules, it becomes important to understand the determinants controlling their PK/PD. This review discusses the determinants that a PK/PD scientist should consider during the design and development of next generation protein therapeutics. In addition, the role of systems PK/PD models in enabling rational development of the next generation protein therapeutics is emphasized.

  17. NOAA Next Generation Radar (NEXRAD) Level 3 Products

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset consists of Level 3 weather radar products collected from Next-Generation Radar (NEXRAD) stations located in the contiguous United States, Alaska,...

  18. NOAA Next Generation Radar (NEXRAD) Level 2 Base Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset consists of Level II weather radar data collected from Next-Generation Radar (NEXRAD) stations located in the contiguous United States, Alaska, Hawaii,...

  19. The next generation of command post computing

    Science.gov (United States)

    Arnold, Ross D.; Lieb, Aaron J.; Samuel, Jason M.; Burger, Mitchell A.

    2015-05-01

    The future of command post computing demands an innovative new solution to address a variety of challenging operational needs. The Command Post of the Future is the Army's primary command and control decision support system, providing situational awareness and collaborative tools for tactical decision making, planning, and execution management from Corps to Company level. However, as the U.S. Army moves towards a lightweight, fully networked battalion, disconnected operations, thin client architecture and mobile computing become increasingly essential. The Command Post of the Future is not designed to support these challenges in the coming decade. Therefore, research into a hybrid blend of technologies is in progress to address these issues. This research focuses on a new command and control system utilizing the rich collaboration framework afforded by Command Post of the Future coupled with a new user interface consisting of a variety of innovative workspace designs. This new system is called Tactical Applications. This paper details a brief history of command post computing, presents the challenges facing the modern Army, and explores the concepts under consideration for Tactical Applications that meet these challenges in a variety of innovative ways.

  20. Next generation diode lasers with enhanced brightness

    Science.gov (United States)

    Ried, S.; Rauch, S.; Irmler, L.; Rikels, J.; Killi, A.; Papastathopoulos, E.; Sarailou, E.; Zimer, H.

    2018-02-01

    High-power diode lasers are nowadays well established manufacturing tools in high power materials processing, mainly for tactile welding, surface treatment and cladding applications. Typical beam parameter products (BPP) of such lasers range from 30 to 50 mm·mrad at several kilowatts of output power. TRUMPF offers a product line of diode lasers to its customers ranging from 150 W up to 6 kW of output power. These diode lasers combine high reliability with small footprint and high efficiency. However, up to now these lasers are limited in brightness due to the commonly used spatial and coarse spectral beam combining techniques. Recently diode lasers with enhanced brightness have been presented by use of dense wavelength multiplexing (DWM). In this paper we report on TRUMPF's diode lasers utilizing DWM. We demonstrate a 2 kW and a 4 kW system ideally suited for fine welding and scanner welding applications. The typical laser efficiency is in the range of 50%. The system offers plug and play exchange of the fiber beam delivery cable, multiple optical outputs and integrated cooling in a very compact package. An advanced control system offers flexible integration in any customer's shop floor environment and includes industry 4.0 capabilities (e.g. condition monitoring and predictive maintenance).

  1. Solution processing of next-generation nanocrystal solar cells

    Science.gov (United States)

    van Embden, J.; Chesman, A. S. R.; Duffy, N. W.; Della Gaspera, E.; Jasieniak, J. J.

    2013-12-01

    Next-generation solar cells will be fabricated from low-cost and earth abundant elements, using processes that are amenable to printing on a variety of light-weight substrates. The utilization of compositionally and structurally controlled colloidal nanocrystals as building blocks for such devices fulfills these criteria. Our recent efforts in developing kesterite Cu2ZnSnS4 (CZTS) nanocrystals, one of the most promising materials to emerge in this area, enable the deposition of CZTS thin-films directly from a variety of solution-processed methods. Nanocrystalline thin films possess poor electronic properties, which precludes their use in solar cell devices. In order to overcome this, thermal treatment steps under an atmosphere of vaporous selenium are applied to induce large scale crystallite growth and the production of selenized CZTSSe films. This process results in a highly photoactive p-type layer. The n-type cadmium sulfide layer is also deposited from solution using chemical bath deposition. We will discuss each of these accomplishments in detail, highlighting the significant challenges that need to be overcome in order to fabricate working CZTSSe thin film solar cells.

  2. Assessing the Genetics Content in the Next Generation Science Standards.

    Directory of Open Access Journals (Sweden)

    Katherine S Lontok

    Full Text Available Science standards have a long history in the United States and currently form the backbone of efforts to improve primary and secondary education in science, technology, engineering, and math (STEM. Although there has been much political controversy over the influence of standards on teacher autonomy and student performance, little light has been shed on how well standards cover science content. We assessed the coverage of genetics content in the Next Generation Science Standards (NGSS using a consensus list of American Society of Human Genetics (ASHG core concepts. We also compared the NGSS against state science standards. Our goals were to assess the potential of the new standards to support genetic literacy and to determine if they improve the coverage of genetics concepts relative to state standards. We found that expert reviewers cannot identify ASHG core concepts within the new standards with high reliability, suggesting that the scope of content addressed by the standards may be inconsistently interpreted. Given results that indicate that the disciplinary core ideas (DCIs included in the NGSS documents produced by Achieve, Inc. clarify the content covered by the standards statements themselves, we recommend that the NGSS standards statements always be viewed alongside their supporting disciplinary core ideas. In addition, gaps exist in the coverage of essential genetics concepts, most worryingly concepts dealing with patterns of inheritance, both Mendelian and complex. Finally, state standards vary widely in their coverage of genetics concepts when compared with the NGSS. On average, however, the NGSS support genetic literacy better than extant state standards.

  3. Assessing the Genetics Content in the Next Generation Science Standards.

    Science.gov (United States)

    Lontok, Katherine S; Zhang, Hubert; Dougherty, Michael J

    2015-01-01

    Science standards have a long history in the United States and currently form the backbone of efforts to improve primary and secondary education in science, technology, engineering, and math (STEM). Although there has been much political controversy over the influence of standards on teacher autonomy and student performance, little light has been shed on how well standards cover science content. We assessed the coverage of genetics content in the Next Generation Science Standards (NGSS) using a consensus list of American Society of Human Genetics (ASHG) core concepts. We also compared the NGSS against state science standards. Our goals were to assess the potential of the new standards to support genetic literacy and to determine if they improve the coverage of genetics concepts relative to state standards. We found that expert reviewers cannot identify ASHG core concepts within the new standards with high reliability, suggesting that the scope of content addressed by the standards may be inconsistently interpreted. Given results that indicate that the disciplinary core ideas (DCIs) included in the NGSS documents produced by Achieve, Inc. clarify the content covered by the standards statements themselves, we recommend that the NGSS standards statements always be viewed alongside their supporting disciplinary core ideas. In addition, gaps exist in the coverage of essential genetics concepts, most worryingly concepts dealing with patterns of inheritance, both Mendelian and complex. Finally, state standards vary widely in their coverage of genetics concepts when compared with the NGSS. On average, however, the NGSS support genetic literacy better than extant state standards.

  4. Digital Earth reloaded – Beyond the next generation

    International Nuclear Information System (INIS)

    Ehlers, M; Woodgate, P; Annoni, A; Schade, S

    2014-01-01

    Digital replicas (or 'mirror worlds') of complex entities and systems are now routine in many fields such as aerospace engineering; archaeology; medicine; or even fashion design. The Digital Earth (DE) concept as a digital replica of the entire planet occurs in Al Gore's 1992 book Earth in the Balance and was popularized in his speech at the California Science Center in January 1998. It played a pivotal role in stimulating the development of a first generation of virtual globes, typified by Google Earth that achieved many elements of this vision. Almost 15 years after Al Gore's speech, the concept of DE needs to be re-evaluated in the light of the many scientific and technical developments in the fields of information technology, data infrastructures, citizen?s participation, and earth observation that have taken place since. This paper intends to look beyond the next generation predominantly based on the developments of fields outside the spatial sciences, where concepts, software, and hardware with strong relationships to DE are being developed without referring to this term. It also presents a number of guiding criteria for future DE developments

  5. Developing the Next Generation Shell Buckling Design Factors and Technologies

    Science.gov (United States)

    Hilburger, Mark W.

    2012-01-01

    NASA s Shell Buckling Knockdown Factor (SBKF) Project was established in the spring of 2007 by the NASA Engineering and Safety Center (NESC) in collaboration with the Constellation Program and Exploration Systems Mission Directorate. The SBKF project has the current goal of developing less-conservative, robust shell buckling design factors (a.k.a. knockdown factors) and design and analysis technologies for light-weight stiffened metallic launch vehicle (LV) structures. Preliminary design studies indicate that implementation of these new knockdown factors can enable significant reductions in mass and mass-growth in these vehicles and can help mitigate some of NASA s LV development and performance risks. In particular, it is expected that the results from this project will help reduce the reliance on testing, provide high-fidelity estimates of structural performance, reliability, robustness, and enable increased payload capability. The SBKF project objectives and approach used to develop and validate new design technologies are presented, and provide a glimpse into the future of design of the next generation of buckling-critical launch vehicle structures.

  6. Examination of concept of next generation computer. Progress report 1999

    International Nuclear Information System (INIS)

    Higuchi, Kenji; Hasegawa, Yukihiro; Hirayama, Toshio

    2000-12-01

    The Center for Promotion of Computational Science and Engineering has conducted R and D works on the technology of parallel processing and has started the examination of the next generation computer in 1999. This report describes the behavior analyses of quantum calculation codes. It also describes the consideration for the analyses and examination results for the method to reduce cash misses. Furthermore, it describes a performance simulator that is being developed to quantitatively examine the concept of the next generation computer. (author)

  7. The Next Generation ATLAS Production System

    CERN Document Server

    Borodin, Mikhail; The ATLAS collaboration; Golubkov, Dmitry; Klimentov, Alexei; Maeno, Tadashi; Mashinistov, Ruslan; Vaniachine, Alexandre

    2015-01-01

    The ATLAS experiment at LHC data processing and simulation grows continuously, as more data and more use cases emerge. For data processing the ATLAS experiment adopted the data transformation approach, where software applications transform the input data into outputs. In the ATLAS production system, each data transformation is represented by a task, a collection of many jobs, dynamically submitted by the ATLAS workload management system (PanDA/JEDI) and executed on the Grid, clouds and supercomputers. Patterns in ATLAS data transformation workflows composed of many tasks provided a scalable production system framework for template definitions of the many-tasks workflows. User interface and system logic of these workflows are being implemented in the Database Engine for Tasks (DEFT). Such development required using modern computing technologies and approaches. We report technical details of this development: database implementation, server logic and Web user interface technologies.

  8. Automated speech understanding: the next generation

    Science.gov (United States)

    Picone, J.; Ebel, W. J.; Deshmukh, N.

    1995-04-01

    Modern speech understanding systems merge interdisciplinary technologies from Signal Processing, Pattern Recognition, Natural Language, and Linguistics into a unified statistical framework. These systems, which have applications in a wide range of signal processing problems, represent a revolution in Digital Signal Processing (DSP). Once a field dominated by vector-oriented processors and linear algebra-based mathematics, the current generation of DSP-based systems rely on sophisticated statistical models implemented using a complex software paradigm. Such systems are now capable of understanding continuous speech input for vocabularies of several thousand words in operational environments. The current generation of deployed systems, based on small vocabularies of isolated words, will soon be replaced by a new technology offering natural language access to vast information resources such as the Internet, and provide completely automated voice interfaces for mundane tasks such as travel planning and directory assistance.

  9. Perspectives and Peptides of the Next Generation

    Science.gov (United States)

    Brogden, Kim A.

    Shortly after their discovery, antimicrobial peptides from prokaryotes and eukaryotes were recognized as the next potential generation of pharmaceuticals to treat antibiotic-resistant bacterial infections and septic shock, to preserve food, or to sanitize surfaces. Initial research focused on identifying the spectrum of antimicrobial agents, determining the range of antimicrobial activities against bacterial, fungal, and viral pathogens, and assessing the antimicrobial activity of synthetic peptides versus their natural counterparts. Subsequent research then focused on the mechanisms of antimicrobial peptide activity in model membrane systems not only to identify the mechanisms of antimicrobial peptide activity in microorganisms but also to discern differences in cytotoxicity for prokaryotic and eukaryotic cells. Recent, contemporary work now focuses on current and future efforts to construct hybrid peptides, peptide congeners, stabilized peptides, peptide conjugates, and immobilized peptides for unique and specific applications to control the growth of microorganisms in vitro and in vivo.

  10. TALE nucleases and next generation GM crops.

    KAUST Repository

    Mahfouz, Magdy M.

    2011-04-01

    Site-specific and adaptable DNA binding domains are essential modules to develop genome engineering technologies for crop improvement. Transcription activator-like effectors (TALEs) proteins are used to provide a highly specific and adaptable DNA binding modules. TALE chimeric nucleases (TALENs) were used to generate site-specific double strand breaks (DSBs) in vitro and in yeast, Caenorhabditis elegans, mammalian and plant cells. The genomic DSBs can be generated at predefined and user-selected loci and repaired by either the non-homologous end joining (NHEJ) or homology dependent repair (HDR). Thus, TALENs can be used to achieve site-specific gene addition, stacking, deletion or inactivation. TALE-based genome engineering tools should be powerful to develop new agricultural biotechnology approaches for crop improvement. Here, we discuss the recent research and the potential applications of TALENs to accelerate the generation of genomic variants through targeted mutagenesis and to produce a non-transgenic GM crops with the desired phenotype.

  11. Training the next generation's nephrology workforce.

    Science.gov (United States)

    Berns, Jeffrey S; Ellison, David H; Linas, Stuart L; Rosner, Mitchell H

    2014-09-05

    The subspecialty of nephrology faces several critical challenges, including declining interest among medical students and internal medicine residents and worrisome declines in the number of applicants for nephrology fellowships. There is an urgent need to more clearly define the subspecialty and its scope of practice, reinvigorate meaningful research training and activities among trainees, and ensure that fellows who complete training and enter the practice of nephrology are experts in the broad scope of nephrology. This need requires a critical look at fellowship training programs and training requirements. A new workforce analysis is also needed that is not focused on primarily meeting estimated future clinical needs but rather, ensuring that there is alignment of supply and demand for nephrology trainees, which will ensure that those entering nephrology fellowships are highly qualified and capable of becoming outstanding nephrologists and that there are desirable employment opportunities for them when they complete their training. Copyright © 2014 by the American Society of Nephrology.

  12. Ceramics composites for next generation nuclear reactors

    International Nuclear Information System (INIS)

    Pouchon, Manuel A.; Rebac, Tomislav; Chen, Jiachao; Dai, Yong; Hoffelner, Wolfgang

    2011-01-01

    Silicon carbide and carbon based composite materials are promising candidates for structural components of future nuclear systems. From non nuclear applications, both, the silicon carbide and the carbon matrix are well known for their excellent high temperature behavior and in case of the carbide, for the chemical inertness. The usage of these materials in their composite variant is inevitable, as the additionally introduced ductility is absolutely necessary in safety relevant components. Possible applications are structural components in high temperature reactors and claddings of advanced reactor systems, such as gas cooled fast reactors, including subcritical ones. The basic mechanical behavior of many of these composite materials is well known, however, little data is available about the degradation in mechanical performance after irradiation. The present paper investigates the mechanical behavior of four different composite materials before and after proton and neutron irradiation. The testing method is a three point bend experiment on non-notched sample bars. Four kinds of materials were tested. Two chemically vapor infiltrated CVI composites with silicon carbide matrices, one with a 2D silicon carbide fiber structure, and the other one with carbon fibers woven in a 2D structure. The two others were liquid silicon infiltrated LSI, both with carbon fibers, but one with a random and the other one with a 2D woven structure. The CVI samples with carbon fibers showed the highest mechanical strength after irradiation. The CVI material with silicon carbide fibers degraded most, but starting from a very high strength before irradiation. Both LSI materials showed a quite constant performance, before and after irradiation. (author)

  13. DNA qualification workflow for next generation sequencing of histopathological samples.

    Directory of Open Access Journals (Sweden)

    Michele Simbolo

    Full Text Available Histopathological samples are a treasure-trove of DNA for clinical research. However, the quality of DNA can vary depending on the source or extraction method applied. Thus a standardized and cost-effective workflow for the qualification of DNA preparations is essential to guarantee interlaboratory reproducible results. The qualification process consists of the quantification of double strand DNA (dsDNA and the assessment of its suitability for downstream applications, such as high-throughput next-generation sequencing. We tested the two most frequently used instrumentations to define their role in this process: NanoDrop, based on UV spectroscopy, and Qubit 2.0, which uses fluorochromes specifically binding dsDNA. Quantitative PCR (qPCR was used as the reference technique as it simultaneously assesses DNA concentration and suitability for PCR amplification. We used 17 genomic DNAs from 6 fresh-frozen (FF tissues, 6 formalin-fixed paraffin-embedded (FFPE tissues, 3 cell lines, and 2 commercial preparations. Intra- and inter-operator variability was negligible, and intra-methodology variability was minimal, while consistent inter-methodology divergences were observed. In fact, NanoDrop measured DNA concentrations higher than Qubit and its consistency with dsDNA quantification by qPCR was limited to high molecular weight DNA from FF samples and cell lines, where total DNA and dsDNA quantity virtually coincide. In partially degraded DNA from FFPE samples, only Qubit proved highly reproducible and consistent with qPCR measurements. Multiplex PCR amplifying 191 regions of 46 cancer-related genes was designated the downstream application, using 40 ng dsDNA from FFPE samples calculated by Qubit. All but one sample produced amplicon libraries suitable for next-generation sequencing. NanoDrop UV-spectrum verified contamination of the unsuccessful sample. In conclusion, as qPCR has high costs and is labor intensive, an alternative effective standard

  14. DNA Qualification Workflow for Next Generation Sequencing of Histopathological Samples

    Science.gov (United States)

    Simbolo, Michele; Gottardi, Marisa; Corbo, Vincenzo; Fassan, Matteo; Mafficini, Andrea; Malpeli, Giorgio; Lawlor, Rita T.; Scarpa, Aldo

    2013-01-01

    Histopathological samples are a treasure-trove of DNA for clinical research. However, the quality of DNA can vary depending on the source or extraction method applied. Thus a standardized and cost-effective workflow for the qualification of DNA preparations is essential to guarantee interlaboratory reproducible results. The qualification process consists of the quantification of double strand DNA (dsDNA) and the assessment of its suitability for downstream applications, such as high-throughput next-generation sequencing. We tested the two most frequently used instrumentations to define their role in this process: NanoDrop, based on UV spectroscopy, and Qubit 2.0, which uses fluorochromes specifically binding dsDNA. Quantitative PCR (qPCR) was used as the reference technique as it simultaneously assesses DNA concentration and suitability for PCR amplification. We used 17 genomic DNAs from 6 fresh-frozen (FF) tissues, 6 formalin-fixed paraffin-embedded (FFPE) tissues, 3 cell lines, and 2 commercial preparations. Intra- and inter-operator variability was negligible, and intra-methodology variability was minimal, while consistent inter-methodology divergences were observed. In fact, NanoDrop measured DNA concentrations higher than Qubit and its consistency with dsDNA quantification by qPCR was limited to high molecular weight DNA from FF samples and cell lines, where total DNA and dsDNA quantity virtually coincide. In partially degraded DNA from FFPE samples, only Qubit proved highly reproducible and consistent with qPCR measurements. Multiplex PCR amplifying 191 regions of 46 cancer-related genes was designated the downstream application, using 40 ng dsDNA from FFPE samples calculated by Qubit. All but one sample produced amplicon libraries suitable for next-generation sequencing. NanoDrop UV-spectrum verified contamination of the unsuccessful sample. In conclusion, as qPCR has high costs and is labor intensive, an alternative effective standard workflow for

  15. Prometheus: a next-generation monitoring system

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    Prometheus is an open eco-system that provides an end-to-end approach to infrastructure and application monitoring. It covers all levels beginning with easy instrumentation based on a flexible, multi-dimensional data model. The Prometheus server itself collects and stores time series while trying to maintain operational simplicity while being adaptable to varying scales and layouts of infrastructure. By integrating with a wide range of service discovery systems, it always stays in sync with the world it is monitoring. The powerful query language allows us to ask complex questions and can be applied seamlessly between ad-hoc investigation and static dashboarding. It is also directly applied in the eco-system's alerting layer, which favors a time-series based over and event driven approach. In this talk we will look at all aspects of Prometheus from the high-level philosophy behind its design to its practical concerns of implementation and operation. About the speaker Fabian Reinartz is a software eng...

  16. Next generation sequencing and the future of genetic diagnosis.

    Science.gov (United States)

    Lohmann, Katja; Klein, Christine

    2014-10-01

    The introduction of next generation sequencing (NGS) has led to an exponential increase of elucidated genetic causes in both extremely rare diseases and common but heterogeneous disorders. It can be applied to the whole or to selected parts of the genome (genome or exome sequencing, gene panels). NGS is not only useful in large extended families with linkage information, but may also be applied to detect de novo mutations or mosaicism in sporadic patients without a prior hypothesis about the mutated gene. Currently, NGS is applied in both research and clinical settings, and there is a rapid transition of research findings to diagnostic applications. These developments may greatly help to minimize the "diagnostic odyssey" for patients as whole-genome analysis can be performed in a few days at reasonable costs compared with gene-by-gene analysis based on Sanger sequencing following diverse clinical tests. Despite the enthusiasm about NGS, one has to keep in mind its limitations, such as a coverage and accuracy of define standards for NGS with respect to run quality and variant interpretation, as well as mechanisms of quality control. Further, there are ethical challenges including incidental findings and how to guide unaffected probands seeking direct-to-customer testing. However, taken together, the application of NGS in research and diagnostics provides a tremendous opportunity to better serve our patients.

  17. Next Generation Sequencing Methods for Diagnosis of Epilepsy Syndromes

    Directory of Open Access Journals (Sweden)

    Paul Dunn

    2018-02-01

    Full Text Available Epilepsy is a neurological disorder characterized by an increased predisposition for seizures. Although this definition suggests that it is a single disorder, epilepsy encompasses a group of disorders with diverse aetiologies and outcomes. A genetic basis for epilepsy syndromes has been postulated for several decades, with several mutations in specific genes identified that have increased our understanding of the genetic influence on epilepsies. With 70-80% of epilepsy cases identified to have a genetic cause, there are now hundreds of genes identified to be associated with epilepsy syndromes which can be analyzed using next generation sequencing (NGS techniques such as targeted gene panels, whole exome sequencing (WES and whole genome sequencing (WGS. For effective use of these methodologies, diagnostic laboratories and clinicians require information on the relevant workflows including analysis and sequencing depth to understand the specific clinical application and diagnostic capabilities of these gene sequencing techniques. As epilepsy is a complex disorder, the differences associated with each technique influence the ability to form a diagnosis along with an accurate detection of the genetic etiology of the disorder. In addition, for diagnostic testing, an important parameter is the cost-effectiveness and the specific diagnostic outcome of each technique. Here, we review these commonly used NGS techniques to determine their suitability for application to epilepsy genetic diagnostic testing.

  18. The Next Generation of HLA Image Products

    Science.gov (United States)

    Gaffney, N. I.; Casertano, S.; Ferguson, B.

    2012-09-01

    providing a more hierarchical metadata storage system than key value pair FITS headers provide. In this poster we will discuss the changes to the pipeline processing and source list generation and the lessons learned which may be applicable to other archive projects as well as discuss our new metadata curation and preservation process.

  19. NEXT GENERATION GAS TURBINE (NGGT) SYSTEMS STUDY

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    2001-12-05

    to how they could serve multiple applications, both in terms of incorporation of technology into current products, as well as to an NGGT product. In summary, potential program costs are shown for development of the candidate systems along with the importance of future DOE enabling participation. Three main conclusions have been established via this study: (1) Rapid recent changes within the power generation regulatory environment and the resulting ''bubble'' of gas turbine orders has altered the timing and relative significance associated with the conclusions of the ADL study upon which the original DOE NGGT solicitation was based. (2) Assuming that the relevant technologies were developed and available for an NGGT market opportunity circa 2010, the top candidate system that meets or exceeds the DOE PRDA requirements was determined to be a hybrid aero-derivative/heavy duty concept. (3) An investment by DOE of approximately $23MM/year to develop NGGT technologies near/mid term for validation and migration into a reasonable fraction of the installed base of GE F-class products could be leveraged into $1.2B Public Benefit, with greatest benefits resulting from RAM improvements. In addition to the monetary Public Benefit, there is also significant benefit in terms of reduced energy consumption, and reduced power plant land usage.

  20. Microbiome Selection Could Spur Next-Generation Plant Breeding Strategies.

    Science.gov (United States)

    Gopal, Murali; Gupta, Alka

    2016-01-01

    method - for realizing this next-generation plant breeding approach. Our aim, thus, is to bring closer the information accrued through the advanced nucleotide sequencing and bioinformatics in conjunction with conventional culture-dependent isolation method for practical application in plant breeding and overall agriculture.

  1. Next Generation Nuclear Plant Structures, Systems, and Components Safety Classification White Paper

    Energy Technology Data Exchange (ETDEWEB)

    Pete Jordan

    2010-09-01

    This white paper outlines the relevant regulatory policy and guidance for a risk-informed approach for establishing the safety classification of Structures, Systems, and Components (SSCs) for the Next Generation Nuclear Plant and sets forth certain facts for review and discussion in order facilitate an effective submittal leading to an NGNP Combined Operating License application under 10 CFR 52.

  2. A Bold Experiment: Teachers Team with Scientists to Learn Next Generation Science Standards

    Science.gov (United States)

    Gilman, Sharon L.; Fout, Martha C.

    2017-01-01

    The "Next Generation Science Standards" place an emphasis on the practices of science and engineering, where ensuring that students understand and experience how science works is as important as, or maybe more important than, memorizing facts. The idea is that, while some facts may change, the practices will always be applicable, and it…

  3. Next-generation sequencing technology for genetics and genomics of sorghum

    DEFF Research Database (Denmark)

    Luo, Hong; Mocoeur, Anne Raymonde Joelle; Jing, Hai-Chun

    2014-01-01

    The invention and application of Next-Generation Sequencing (NGS) technologies have revolutionized the study of genetics and genomics. Much research which would not even be considered are nowdays being excuted in many laboratories as routine. In this chapter, we introduce the currently available...

  4. Next-Generation Photon Sources for Grand Challenges in Science and Energy

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-05-01

    The next generation of sustainable energy technologies will revolve around transformational new materials and chemical processes that convert energy efficiently among photons, electrons, and chemical bonds. New materials that tap sunlight, store electricity, or make fuel from splitting water or recycling carbon dioxide will need to be much smarter and more functional than today's commodity-based energy materials. To control and catalyze chemical reactions or to convert a solar photon to an electron requires coordination of multiple steps, each carried out by customized materials and interfaces with designed nanoscale structures. Such advanced materials are not found in nature the way we find fossil fuels; they must be designed and fabricated to exacting standards, using principles revealed by basic science. Success in this endeavor requires probing, and ultimately controlling, the interactions among photons, electrons, and chemical bonds on their natural length and time scales. Control science - the application of knowledge at the frontier of science to control phenomena and create new functionality - realized through the next generation of ultraviolet and X-ray photon sources, has the potential to be transformational for the life sciences and information technology, as well as for sustainable energy. Current synchrotron-based light sources have revolutionized macromolecular crystallography. The insights thus obtained are largely in the domain of static structure. The opportunity is for next generation light sources to extend these insights to the control of dynamic phenomena through ultrafast pump-probe experiments, time-resolved coherent imaging, and high-resolution spectroscopic imaging. Similarly, control of spin and charge degrees of freedom in complex functional materials has the potential not only to reveal the fundamental mechanisms of high-temperature superconductivity, but also to lay the foundation for future generations of information science. This

  5. Control technology for nuclear power system of next generation

    International Nuclear Information System (INIS)

    1995-01-01

    This report is the summary of the results obtained by the investigation activities for two years carried out by the expert committee on investigation of control technology for nuclear power system of next generation. The course of investigation is outlined, and as the results, as advanced control technologies, adaptive control. H sub (infinite) control, fuzzy control and the application of autonomous distributed system and genetic algorithm to control; as operation support technology, the operation and monitoring system for nuclear power plants and safety support system; as interface technology which is the basic technology of them, virtual reality, multimedia and so on; further, various problems due to human factors, computer technology, artificial intelligence and others were taken up, and the grasp of the present status and the future subjects was carried out, including the information in international conferences. The items of the investigation are roughly divided into measurement and control technologies, interface technology and operation support, human factors, computer technology and artificial intelligence, and the trend in foreign countries, and the results of investigation for respective items are reported. (K.I.)

  6. Benchmarking of electrolyte mass transport in next generation lithium batteries

    Directory of Open Access Journals (Sweden)

    Jonas Lindberg

    2017-12-01

    Full Text Available Beyond conductivity and viscosity, little is often known about the mass transport properties of next generation lithium battery electrolytes, thus, making performance estimation uncertain when concentration gradients are present, as conductivity only describes performance in the absence of these gradients. This study experimentally measured the diffusion resistivity, originating from voltage loss due to a concentration gradient, together with the ohmic resistivity, obtained from ionic conductivity measurements, hence, evaluating electrolytes both with and without the presence of concentration gradients. Under galvanostatic conditions, the concentration gradients, of all electrolytes examined, developed quickly and the diffusion resistivity rapidly dominated the ohmic resistivity. The electrolytes investigated consisted of lithium salt in: room temperature ionic liquids (RTIL, RTIL mixed organic carbonates, dimethyl sulfoxide (DMSO, and a conventional Li-ion battery electrolyte. At steady state the RTIL electrolytes displayed a diffusion resistivity ~ 20 times greater than the ohmic resistivity. The DMSO-based electrolyte showed mass transport properties similar to the conventional Li-ion battery electrolyte. In conclusion, the results presented in this study show that the diffusion polarization must be considered in applications where high energy and power density are desired.

  7. Precise Thermometry for Next Generation LHC Superconducting Magnet Prototypes

    CERN Document Server

    Datskov, V; Bottura, L; Perez, J C; Borgnolutti, F; Jenninger, B; Ryan, P

    2013-01-01

    The next generation of LHC superconducting magnets is very challenging and must operate in harsh conditions: high radiation doses in a range between 10 and 50 MGy, high voltage environment of 1 to 5 kV during the quench, dynamic high magnetic field up to 12 T, dynamic temperature range 1.8 K to 300 K in 0.6 sec. For magnet performance and long term reliability it is important to study dynamic thermal effects, such as the heat flux through the magnet structure, or measuring hot spot in conductors during a magnet quench with high sampling rates above 200 Hz. Available on the market cryogenic temperature sensors comparison is given. An analytical model for special electrically insulating thermal anchor (Kapton pad) with high voltage insulation is described. A set of instrumentation is proposed for fast monitoring of thermal processes during normal operation, quenches and failure situations. This paper presents the technology applicable for mounting temperature sensors on high voltage superconducting (SC) cables....

  8. Next generation sequencing in breast cancer: first take home messages

    Science.gov (United States)

    Desmedt, Christine; Voet, Thierry; Sotiriou, Christos; Campbell, Peter J

    2013-01-01

    Purpose of the review We are currently on the threshold of a revolution in breast cancer research thanks to the emergence of novel technologies based on next generation sequencing (NGS). In this review, we will describe the different sequencing technologies and platforms, and summarize the main findings from the latest sequencing papers in breast cancer. Recent findings First, the sequencing of a few hundreds of breast tumors has revealed new cancer genes. Although these were not frequently mutated, mutated genes from different patients could be grouped into the deregulation of similar pathways. Second, NGS allowed further exploration of intratumor heterogeneity and revealed that although subclonal mutations were present in all tumors, there was always a dominant clone which comprised at least 50% of the tumor cells. Finally, tumor-specific DNA rearrangements could be detected in the patient’s plasma, suggesting that NGS could be used to personalize the monitoring of the disease. Summary The application of NGS to breast cancer has been associated with tremendous advances and promises for increasing the understanding of the disease. However, there still remain many unanswered questions, such as for example the role of structural changes of tumor genomes in cancer progression and treatment response/resistance. PMID:23014189

  9. Next-generation sequencing for understanding and accelerating crop domestication.

    Science.gov (United States)

    Henry, Robert J

    2012-01-01

    Next generation Sequencing (NGS) provides a powerful tool for discovery of domestication genes in crop plants and their wild relatives. The accelerated domestication of new plant species as crops may be facilitated by this knowledge. Re-sequencing of domesticated genotypes can identify regions of low diversity associated with domestication. Species-specific data can be obtained from related wild species by whole-genome shot-gun sequencing. This sequence data can be used to design species specific polymerase chain reaction (PCR) primers. Sequencing of the products of PCR amplification of target genes can be used to explore genetic variation in large numbers of genes and gene families. Novel allelic variation in close or distant relatives can be characterized by NGS. Examples of recent applications of NGS to capture of genetic diversity for crop improvement include rice, sugarcane and Eucalypts. Populations of large numbers of individuals can be screened rapidly. NGS supports the rapid domestication of new plant species and the efficient identification and capture of novel genetic variation from related species.

  10. Next-generation sequencing (NGS) for assessment of microbial water quality: current progress, challenges, and future opportunities.

    Science.gov (United States)

    Tan, BoonFei; Ng, Charmaine; Nshimyimana, Jean Pierre; Loh, Lay Leng; Gin, Karina Y-H; Thompson, Janelle R

    2015-01-01

    Water quality is an emergent property of a complex system comprised of interacting microbial populations and introduced microbial and chemical contaminants. Studies leveraging next-generation sequencing (NGS) technologies are providing new insights into the ecology of microbially mediated processes that influence fresh water quality such as algal blooms, contaminant biodegradation, and pathogen dissemination. In addition, sequencing methods targeting small subunit (SSU) rRNA hypervariable regions have allowed identification of signature microbial species that serve as bioindicators for sewage contamination in these environments. Beyond amplicon sequencing, metagenomic and metatranscriptomic analyses of microbial communities in fresh water environments reveal the genetic capabilities and interplay of waterborne microorganisms, shedding light on the mechanisms for production and biodegradation of toxins and other contaminants. This review discusses the challenges and benefits of applying NGS-based methods to water quality research and assessment. We will consider the suitability and biases inherent in the application of NGS as a screening tool for assessment of biological risks and discuss the potential and limitations for direct quantitative interpretation of NGS data. Secondly, we will examine case studies from recent literature where NGS based methods have been applied to topics in water quality assessment, including development of bioindicators for sewage pollution and microbial source tracking, characterizing the distribution of toxin and antibiotic resistance genes in water samples, and investigating mechanisms of biodegradation of harmful pollutants that threaten water quality. Finally, we provide a short review of emerging NGS platforms and their potential applications to the next generation of water quality assessment tools.

  11. Physical Configuration of the Next Generation Home Network

    Science.gov (United States)

    Terada, Shohei; Kakishima, Yu; Hanawa, Dai; Oguchi, Kimio

    The number of broadband users is rapidly increasing worldwide. Japan already has over 10 million FTTH users. Another trend is the rapid digitalization of home electrical equipment e. g. digital cameras and hard disc recorders. These trends will encourage the emergence of the next generation home network. In this paper, we introduce the next generation home network image and describe the five domains into which home devices can be classified. We then clarify the optimum medium with which to configure the network given the requirements imposed by the home environment. Wiring cable lengths for three network topologies are calculated. The results gained from the next generation home network implemented on the first phase testbed are shown. Finally, our conclusions are given.

  12. Preparation of next generation set of group cross sections. 3

    International Nuclear Information System (INIS)

    Kaneko, Kunio

    2002-03-01

    This fiscal year, based on the examination result about the evaluation energy range of heavy element unresolved resonance cross sections, the upper energy limit of the energy range, where ultra-fine group cross sections are produced, was raised to 50 keV, and an improvement of the group cross section processing system was promoted. At the same time, reflecting the result of studies carried out till now, a function producing delayed neutron data was added to the general-purpose group cross section processing system , thus the preparation of general purpose group cross section processing system has been completed. On the other hand, the energy structure, data constitution and data contents of next generation group cross section set were determined, and the specification of a 151 groups next generation group cross section set was defined. Based on the above specification, a concrete library format of the next generation cross section set has been determined. After having carried out the above-described work, using the general-purpose group cross section processing system , which was complete in this study, with use of the JENDL-3. 2 evaluated nuclear data, the 151 groups next generation group cross section of 92 nuclides and the ultra fine group resonance cross section library for 29 nuclides have been prepared. Utilizing the 151 groups next generation group cross section set and the ultra-fine group resonance cross-section library, a bench mark test calculation of fast reactors has been performed by using an advanced lattice calculation code. It was confirmed, by comparing the calculation result with a calculation result of continuous energy Monte Carlo code, that the 151 groups next generation cross section set has sufficient accuracy. (author)

  13. NIRS report of investigations for the development of the next generation PET apparatus. FY 2002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-03-01

    The present status of studies conducted by representative technology fields for the development of the next generation PET apparatus, and the summary of opinions given by investigators of nuclear medicine are reported. The former involves chapters of: Summary of representative technologies for the development of the next generation PET apparatus; Count rate analysis of PET apparatuses for the whole body and small animals by PET simulator; Scintillator; DOI (depth of interaction) detector-evaluation of the detector with 256-ch fluorescence polarization-photomultiplier tubes (FP-PMT) trial apparatus etc; Examination of multi-slice DOI-MR compatible detector for PET; Development of application specific integrated circuit (ASIC) for processing the front-end signals; Detector simulation; Circuit for processing PET detector signals; Signal processing-coincidence circuit; Data collection system; Signal processing technology for the next generation PET; Reconstruction of statistical PET image using DOI signals; Monte Carlo simulation and Unique directions-PET for infants and for the whole body autonomic nervous systems and mental activity; and Actual design and evaluation of image reconstruction by statistical means. Opinions are: Progress of clinical PET apparatus; Desirable PET drugs and apparatuses; From clinical practice for the development of the next generation PET apparatus; >From clinical psychiatric studies for the development; From application of drug development and basic researches; From brain PET practice; From clinical PET practice; and The role of National Institute of Radiological Sciences (NIRS) in PET development. Also involved is the publication list. (N.I.)

  14. Next Generation Integrated Environment for Collaborative Work Across Internets

    Energy Technology Data Exchange (ETDEWEB)

    Harvey B. Newman

    2009-02-24

    We are now well-advanced in our development, prototyping and deployment of a high performance next generation Integrated Environment for Collaborative Work. The system, aimed at using the capability of ESnet and Internet2 for rapid data exchange, is based on the Virtual Room Videoconferencing System (VRVS) developed by Caltech. The VRVS system has been chosen by the Internet2 Digital Video (I2-DV) Initiative as a preferred foundation for the development of advanced video, audio and multimedia collaborative applications by the Internet2 community. Today, the system supports high-end, broadcast-quality interactivity, while enabling a wide variety of clients (Mbone, H.323) to participate in the same conference by running different standard protocols in different contexts with different bandwidth connection limitations, has a fully Web-integrated user interface, developers and administrative APIs, a widely scalable video network topology based on both multicast domains and unicast tunnels, and demonstrated multiplatform support. This has led to its rapidly expanding production use for national and international scientific collaborations in more than 60 countries. We are also in the process of creating a 'testbed video network' and developing the necessary middleware to support a set of new and essential requirements for rapid data exchange, and a high level of interactivity in large-scale scientific collaborations. These include a set of tunable, scalable differentiated network services adapted to each of the data streams associated with a large number of collaborative sessions, policy-based and network state-based resource scheduling, authentication, and optional encryption to maintain confidentiality of inter-personal communications. High performance testbed video networks will be established in ESnet and Internet2 to test and tune the implementation, using a few target application-sets.

  15. A two-stage flow-based intrusion detection model for next-generation networks.

    Science.gov (United States)

    Umer, Muhammad Fahad; Sher, Muhammad; Bi, Yaxin

    2018-01-01

    The next-generation network provides state-of-the-art access-independent services over converged mobile and fixed networks. Security in the converged network environment is a major challenge. Traditional packet and protocol-based intrusion detection techniques cannot be used in next-generation networks due to slow throughput, low accuracy and their inability to inspect encrypted payload. An alternative solution for protection of next-generation networks is to use network flow records for detection of malicious activity in the network traffic. The network flow records are independent of access networks and user applications. In this paper, we propose a two-stage flow-based intrusion detection system for next-generation networks. The first stage uses an enhanced unsupervised one-class support vector machine which separates malicious flows from normal network traffic. The second stage uses a self-organizing map which automatically groups malicious flows into different alert clusters. We validated the proposed approach on two flow-based datasets and obtained promising results.

  16. Disaster Management with a Next Generation Disaster Decision Support System

    Science.gov (United States)

    Chen, Y.

    2015-12-01

    As populations become increasingly concentrated in large cities, the world is experiencing an inevitably growing trend towards the urbanisation of disasters. Scientists have contributed significant advances in understanding the geophysical causes of natural hazards and have developed sophisticated tools to predict their effects; while, much less attention has been devoted to tools that increase situational awareness, facilitate leadership, provide effective communication channels and data flow and enhance the cognitive abilities of decision makers and first responders. In this paper, we envisioned the capabilities of a next generation disaster decision support system and hence proposed a state-of-the-art system architecture design to facilitate the decision making process in natural catastrophes such as flood and bushfire by utilising a combination of technologies for multi-channel data aggregation, disaster modelling, visualisation and optimisation. Moreover, we put our thoughts into action by implementing an Intelligent Disaster Decision Support System (IDDSS). The developed system can easily plug in to external disaster models and aggregate large amount of heterogeneous data from government agencies, sensor networks, and crowd sourcing platforms in real-time to enhance the situational awareness of decision makers and offer them a comprehensive understanding of disaster impacts from diverse perspectives such as environment, infrastructure and economy, etc. Sponsored by the Australian Government and the Victorian Department of Justice (Australia), the system was built upon a series of open-source frameworks (see attached figure) with four key components: data management layer, model application layer, processing service layer and presentation layer. It has the potential to be adopted by a range of agencies across Australian jurisdictions to assist stakeholders in accessing, sharing and utilising available information in their management of disaster events.

  17. Authentication of Herbal Supplements Using Next-Generation Sequencing.

    Science.gov (United States)

    Ivanova, Natalia V; Kuzmina, Maria L; Braukmann, Thomas W A; Borisenko, Alex V; Zakharov, Evgeny V

    2016-01-01

    DNA-based testing has been gaining acceptance as a tool for authentication of a wide range of food products; however, its applicability for testing of herbal supplements remains contentious. We utilized Sanger and Next-Generation Sequencing (NGS) for taxonomic authentication of fifteen herbal supplements representing three different producers from five medicinal plants: Echinacea purpurea, Valeriana officinalis, Ginkgo biloba, Hypericum perforatum and Trigonella foenum-graecum. Experimental design included three modifications of DNA extraction, two lysate dilutions, Internal Amplification Control, and multiple negative controls to exclude background contamination. Ginkgo supplements were also analyzed using HPLC-MS for the presence of active medicinal components. All supplements yielded DNA from multiple species, rendering Sanger sequencing results for rbcL and ITS2 regions either uninterpretable or non-reproducible between the experimental replicates. Overall, DNA from the manufacturer-listed medicinal plants was successfully detected in seven out of eight dry herb form supplements; however, low or poor DNA recovery due to degradation was observed in most plant extracts (none detected by Sanger; three out of seven-by NGS). NGS also revealed a diverse community of fungi, known to be associated with live plant material and/or the fermentation process used in the production of plant extracts. HPLC-MS testing demonstrated that Ginkgo supplements with degraded DNA contained ten key medicinal components. Quality control of herbal supplements should utilize a synergetic approach targeting both DNA and bioactive components, especially for standardized extracts with degraded DNA. The NGS workflow developed in this study enables reliable detection of plant and fungal DNA and can be utilized by manufacturers for quality assurance of raw plant materials, contamination control during the production process, and the final product. Interpretation of results should involve an

  18. Next Generation Surfactants for Improved Chemical Flooding Technology

    Energy Technology Data Exchange (ETDEWEB)

    Laura Wesson; Prapas Lohateeraparp; Jeffrey Harwell; Bor-Jier Shiau

    2012-05-31

    The principle objective of this project was to characterize and test current and next generation high performance surfactants for improved chemical flooding technology, focused on reservoirs in the Pennsylvanian-aged (Penn) sands. In order to meet this objective the characteristic curvatures (Cc) of twenty-eight anionic surfactants selected for evaluation for use in chemical flooding formulations were determined. The Cc values ranged from -6.90 to 2.55 with the majority having negative values. Crude oil samples from nine Penn sand reservoirs were analyzed for several properties pertinent to surfactant formulation for EOR application. These properties included equivalent alkane carbon numbers, total acid numbers, and viscosity. The brine samples from these same reservoirs were analyzed for several cations and for total dissolved solids. Surfactant formulations were successfully developed for eight reservoirs by the end of the project period. These formulations were comprised of a tertiary mixture of anionic surfactants. The identities of these surfactants are considered proprietary, but suffice to say the surfactants in each mixture were comprised of varying chemical structures. In addition to the successful development of surfactant formulations for EOR, there were also two successful single-well field tests conducted. There are many aspects that must be considered in the development and implementation of effective surfactant formulations. Taking into account these other aspects, there were four additional studies conducted during this project. These studies focused on the effect of the stability of surfactant formulations in the presence of polymers with an associated examination of polymer rheology, the effect of the presence of iron complexes in the brine on surfactant stability, the potential use of sacrificial agents in order to minimize the loss of surfactant to adsorption, and the effect of electrolytes on surfactant adsorption. In these last four studies

  19. Authentication of Herbal Supplements Using Next-Generation Sequencing.

    Directory of Open Access Journals (Sweden)

    Natalia V Ivanova

    Full Text Available DNA-based testing has been gaining acceptance as a tool for authentication of a wide range of food products; however, its applicability for testing of herbal supplements remains contentious.We utilized Sanger and Next-Generation Sequencing (NGS for taxonomic authentication of fifteen herbal supplements representing three different producers from five medicinal plants: Echinacea purpurea, Valeriana officinalis, Ginkgo biloba, Hypericum perforatum and Trigonella foenum-graecum. Experimental design included three modifications of DNA extraction, two lysate dilutions, Internal Amplification Control, and multiple negative controls to exclude background contamination. Ginkgo supplements were also analyzed using HPLC-MS for the presence of active medicinal components.All supplements yielded DNA from multiple species, rendering Sanger sequencing results for rbcL and ITS2 regions either uninterpretable or non-reproducible between the experimental replicates. Overall, DNA from the manufacturer-listed medicinal plants was successfully detected in seven out of eight dry herb form supplements; however, low or poor DNA recovery due to degradation was observed in most plant extracts (none detected by Sanger; three out of seven-by NGS. NGS also revealed a diverse community of fungi, known to be associated with live plant material and/or the fermentation process used in the production of plant extracts. HPLC-MS testing demonstrated that Ginkgo supplements with degraded DNA contained ten key medicinal components.Quality control of herbal supplements should utilize a synergetic approach targeting both DNA and bioactive components, especially for standardized extracts with degraded DNA. The NGS workflow developed in this study enables reliable detection of plant and fungal DNA and can be utilized by manufacturers for quality assurance of raw plant materials, contamination control during the production process, and the final product. Interpretation of results should

  20. Using next generation transcriptome sequencing to predict an ectomycorrhizal metabolome

    Directory of Open Access Journals (Sweden)

    Cseke Leland J

    2011-05-01

    Full Text Available Abstract Background Mycorrhizae, symbiotic interactions between soil fungi and tree roots, are ubiquitous in terrestrial ecosystems. The fungi contribute phosphorous, nitrogen and mobilized nutrients from organic matter in the soil and in return the fungus receives photosynthetically-derived carbohydrates. This union of plant and fungal metabolisms is the mycorrhizal metabolome. Understanding this symbiotic relationship at a molecular level provides important contributions to the understanding of forest ecosystems and global carbon cycling. Results We generated next generation short-read transcriptomic sequencing data from fully-formed ectomycorrhizae between Laccaria bicolor and aspen (Populus tremuloides roots. The transcriptomic data was used to identify statistically significantly expressed gene models using a bootstrap-style approach, and these expressed genes were mapped to specific metabolic pathways. Integration of expressed genes that code for metabolic enzymes and the set of expressed membrane transporters generates a predictive model of the ectomycorrhizal metabolome. The generated model of mycorrhizal metabolome predicts that the specific compounds glycine, glutamate, and allantoin are synthesized by L. bicolor and that these compounds or their metabolites may be used for the benefit of aspen in exchange for the photosynthetically-derived sugars fructose and glucose. Conclusions The analysis illustrates an approach to generate testable biological hypotheses to investigate the complex molecular interactions that drive ectomycorrhizal symbiosis. These models are consistent with experimental environmental data and provide insight into the molecular exchange processes for organisms in this complex ecosystem. The method used here for predicting metabolomic models of mycorrhizal systems from deep RNA sequencing data can be generalized and is broadly applicable to transcriptomic data derived from complex systems.

  1. Vaccine candidate discovery for the next generation of malaria vaccines.

    Science.gov (United States)

    Tuju, James; Kamuyu, Gathoni; Murungi, Linda M; Osier, Faith H A

    2017-10-01

    Although epidemiological observations, IgG passive transfer studies and experimental infections in humans all support the feasibility of developing highly effective malaria vaccines, the precise antigens that induce protective immunity remain uncertain. Here, we review the methodologies applied to vaccine candidate discovery for Plasmodium falciparum malaria from the pre- to post-genomic era. Probing of genomic and cDNA libraries with antibodies of defined specificities or functional activity predominated the former, whereas reverse vaccinology encompassing high throughput in silico analyses of genomic, transcriptomic or proteomic parasite data sets is the mainstay of the latter. Antibody-guided vaccine design spanned both eras but currently benefits from technological advances facilitating high-throughput screening and downstream applications. We make the case that although we have exponentially increased our ability to identify numerous potential vaccine candidates in a relatively short space of time, a significant bottleneck remains in their validation and prioritization for evaluation in clinical trials. Longitudinal cohort studies provide supportive evidence but results are often conflicting between studies. Demonstration of antigen-specific antibody function is valuable but the relative importance of one mechanism over another with regards to protection remains undetermined. Animal models offer useful insights but may not accurately reflect human disease. Challenge studies in humans are preferable but prohibitively expensive. In the absence of reliable correlates of protection, suitable animal models or a better understanding of the mechanisms underlying protective immunity in humans, vaccine candidate discovery per se may not be sufficient to provide the paradigm shift necessary to develop the next generation of highly effective subunit malaria vaccines. © 2017 The Authors. Immunology Published by John Wiley & Sons Ltd.

  2. The Next Generation of the Montage Image Mopsaic Engine

    Science.gov (United States)

    Berriman, G. Bruce; Good, John; Rusholme, Ben; Robitaille, Thomas

    2016-01-01

    We have released a major upgrade of the Montage image mosaic engine (http://montage.ipac.caltech.edu) , as part of a program to develop the next generation of the engine in response to the rapid changes in the data processing landscape in Astronomy, which is generating ever larger data sets in ever more complex formats . The new release (version 4) contains modules dedicated to creating and managing mosaics of data stored as multi-dimensional arrays ("data cubes"). The new release inherits the architectural benefits of portability and scalability of the original design. The code is publicly available on Git Hub and the Montage web page. The release includes a command line tool that supports visualization of large images, and the beta-release of a Python interface to the visualization tool. We will provide examples on how to use these these features. We are generating a mosaic of the Galactic Arecibo L-band Feed Array HI (GALFA-HI) Survey maps of neutral hydrogen in and around our Milky Way Galaxy, to assess the performance at scale and to develop tools and methodologies that will enable scientists inexpert in cloud processing to exploit could platforms for data processing and product generation at scale. Future releases include support for an R-tree based mechanism for fast discovery of and access to large data sets and on-demand access to calibrated SDSS DR9 data that exploits it; support for the Hierarchical Equal Area isoLatitude Pixelization (HEALPix) scheme, now standard for projects investigating cosmic background radiation (Gorski et al 2005); support fort the Tessellated Octahedral Adaptive Subdivision Transform (TOAST), the sky partitioning sky used by the WorldWide Telescope (WWT); and a public applications programming interface (API) in C that can be called from other languages, especially Python.

  3. SNAP: Small Next-generation Atmospheric Probe Concept

    Science.gov (United States)

    Sayanagi, K. M.; Dillman, R. A.; Atkinson, D. H.; Li, J.; Saikia, S.; Simon, A. A.; Spilker, T. R.; Wong, M. H.; Hope, D.

    2017-12-01

    We present a concept for a small, atmospheric probe that could be flexibly added to future missions that orbit or fly-by a giant planet as a secondary payload, which we call the Small Next-generation Atmospheric Probe (SNAP). SNAP's main scientific objectives are to determine the vertical distribution of clouds and cloud-forming chemical species, thermal stratification, and wind speed as a function of depth. As a case study, we present the advantages, cost and risk of adding SNAP to the future Uranus Orbiter and Probe flagship mission; in combination with the mission's main probe, SNAP would perform atmospheric in-situ measurements at a second location, and thus enable and enhance the scientific objectives recommended by the 2013 Planetary Science Decadal Survey and the 2014 NASA Science Plan to determine atmospheric spatial variabilities. We envision that the science objectives can be achieved with a 30-kg entry probe 0.5m in diameter (less than half the size of the Galileo probe) that reaches 5-bar pressure-altitude and returns data to Earth via the carrier spacecraft. As the baseline instruments, the probe will carry an Atmospheric Structure Instrument (ASI) that measures the temperature, pressure and acceleration, a carbon nanotube-based NanoChem atmospheric composition sensor, and an Ultra-Stable Oscillator (USO) to conduct a Doppler Wind Experiment (DWE). We also catalog promising technologies currently under development that will strengthen small atmospheric entry probe missions in the future. While SNAP is applicable to multiple planets, we examine the feasibility, benefits and impacts of adding SNAP to the Uranus Orbiter and Probe flagship mission. Our project is supported by NASA PSDS3 grant NNX17AK31G.

  4. Next Generation UV Coronagraph Instrumentation for Solar Cycle-24

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... Measurements to date from sounding rockets, the shuttle deployed Spartan 201 satellite and the Solar and Heliospheric Observatory (SOHO) have utilized high resolution spectroscopy over a very limited instantaneous field of view. New concepts for next generation instrumentation include imaging ...

  5. Next Generation Diagnostic System (NGDS) Increment 1 Early Fielding Report

    Science.gov (United States)

    2017-06-07

    laptop in order to utilize the Windows 10 operating system required by the Department of Defense. Additional developmental and cybersecurity testing...upgraded the NGDS laptop in order to implement the Windows 10 operating system required by the Department of Defense. Additional cybersecurity...Director, Operational Test and Evaluation Next Generation Diagnostic System (NGDS) Increment 1 Early Fielding Report   June 2017

  6. Next-generation sequencing for investigating the diversity of ...

    African Journals Online (AJOL)

    pathogenic bacteria in water. Recent technological advances in next-generation sequencing (NGS) offer better prospects for detection of pathogenic microorganisms and investigating their diversity [11]. NGS can quickly generate huge amounts of DNA reads, and the technique is affordable [12]. In this study, the pathogens ...

  7. In Conversation with Naser Faruqui: A 'Next Generation Water Leader'

    International Development Research Centre (IDRC) Digital Library (Canada)

    2011-02-25

    Feb 25, 2011 ... Since joining IDRC in 1995, Faruqui has overseen several applied research projects related to water resources management, water supply and ... Second World Water Forum, which will be held from March 17-22 in The Hague, Faruqui will meet with the other "next generation water leaders" for the first time.

  8. Next-generation sequencing approaches to understanding the oral microbiome

    NARCIS (Netherlands)

    Zaura, E.

    2012-01-01

    Until recently, the focus in dental research has been on studying a small fraction of the oral microbiome—so-called opportunistic pathogens. With the advent of next-generation sequencing (NGS) technologies, researchers now have the tools that allow for profiling of the microbiomes and metagenomes at

  9. Next Generation UV Coronagraph Instrumentation for Solar Cycle-24

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... New concepts for next generation instrumentation include imaging ultraviolet spectrocoronagraphs and large aperture ultraviolet coronagraph spectrometers. An imaging instrument would be the first to obtain absolute spectral line intensities of the extended corona over a wide field of view. Such images ...

  10. Advancing Next-Generation Energy in Indian Country (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    2012-08-01

    This fact sheet provides information on the Alaska Native governments selected to receive assistance from the Strategic Technical Assistance Response Team (START) Program, a U.S. Department of Energy Office of Indian Energy Policy and Programs (DOE-IE) initiative to provide technical expertise to support the development of next-generation energy projects in Indian Country.

  11. Computational Challenges of Next Generation Sequencing Pipelines Using Heterogeneous Systems

    NARCIS (Netherlands)

    Houtgast, E.J.; Sima, V.M.; Bertels, K.L.M.; Al-Ars, Z.

    2016-01-01

    We are rapidly entering the era of genomics. The dramatic cost reduction of DNA sequencing due to the introduction of Next Generation Sequencing (NGS) techniques has resulted in an exponential growth of genetics data. The amount of data generated, and its associated processing into useful

  12. Estimating individual admixture proportions from next generation sequencing data

    DEFF Research Database (Denmark)

    Skotte, Line; Korneliussen, Thorfinn Sand; Albrechtsen, Anders

    2013-01-01

    Inference of population structure and individual ancestry is important both for population genetics and for association studies. With next generation sequencing technologies it is possible to obtain genetic data for all accessible genetic variations in the genome. Existing methods for admixture...

  13. The Next Generation of Science Standards: Implications for Biology Education

    Science.gov (United States)

    Bybee, Rodger W.

    2012-01-01

    The release of A Framework for K-12 Science Education: Practices, Crosscutting Concepts, and Core Ideas (NRC, 2012) provides the basis for the next generation of science standards. This article first describes that foundation for the life sciences; it then presents a draft standard for natural selection and evolution. Finally, there is a…

  14. Preliminary thoughts on the data acquisition for the next generation ...

    Indian Academy of Sciences (India)

    Abstract. Preliminary thoughts about the data acquisition system to be developed for the next generation of large area silicon tracker are presented in this paper. This paper describes the set of data delivered by these tracking systems, and the various stages of processing and data flow transmission from the front-end chip ...

  15. Preliminary thoughts on the data acquisition for the next generation ...

    Indian Academy of Sciences (India)

    Preliminary thoughts about the data acquisition system to be developed for the next generation of large area silicon tracker are presented in this paper. This paper describes the set of data delivered by these tracking systems, and the various stages of processing and data flow transmission from the front-end chip sitting on ...

  16. Targeted enrichment strategies for next-generation plant biology

    Science.gov (United States)

    Richard Cronn; Brian J. Knaus; Aaron Liston; Peter J. Maughan; Matthew Parks; John V. Syring; Joshua. Udall

    2012-01-01

    The dramatic advances offered by modem DNA sequencers continue to redefine the limits of what can be accomplished in comparative plant biology. Even with recent achievements, however, plant genomes present obstacles that can make it difficult to execute large-scale population and phylogenetic studies on next-generation sequencing platforms. Factors like large genome...

  17. ERP II - Next-generation Extended Enterprise Resource Planning

    DEFF Research Database (Denmark)

    Møller, Charles

    2003-01-01

    ERP II (ERP/2) systems is a new concept introduced by Gartner Group in 2000 in order to label the latest extensions of the ERP-systems. The purpose of this paper is to explore the next-generation of ERP systems, the Extended Enterprise Resource Planning (EERP or as we prefer to use: e...... impact on extended enterprise architecture....

  18. Using Digital Watermarking for Securing Next Generation Media Broadcasts

    Science.gov (United States)

    Birk, Dominik; Gaines, Seán

    The Internet presents a problem for the protection of intellectual property. Those who create content must be adequately compensated for the use of their works. Rights agencies who monitor the use of these works exist in many jurisdictions. In the traditional broadcast environment this monitoring is a difficult task. With Internet Protocol Television (IPTV) and Next Generation Networks (NGN) this situation is further complicated.

  19. Brain–muscle interface: The next-generation BMI

    Indian Academy of Sciences (India)

    2011-05-16

    muscle interface: The next-generation BMI. Radhika Rajan Neeraj Jain. Volume 36 Issue 2 June 2011 pp 201-203. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/036/02/0201- ...

  20. Next Generation Science Standards: All Standards, All Students

    Science.gov (United States)

    Lee, Okhee; Miller, Emily C.; Januszyk, Rita

    2014-01-01

    The Next Generation Science Standards (NGSS) offer a vision of science teaching and learning that presents both learning opportunities and demands for all students, particularly student groups that have traditionally been underserved in science classrooms. The NGSS have addressed issues of diversity and equity from their inception, and the NGSS…

  1. Addressing Three Common Myths about the Next Generation Science Standards

    Science.gov (United States)

    Huff, Kenneth L.

    2016-01-01

    Although the "Next Generation Science Standards" (NGSS Lead States 2013) were released over two years ago, misconceptions about what they are--and are not--persist. The "NGSS" provide for consistent science education opportunities for all students--regardless of demographics--with a level of rigor expected in every location and…

  2. Answers to Teachers' Questions about the Next Generation Science Standards

    Science.gov (United States)

    Workosky, Cindy; Willard, Ted

    2015-01-01

    K-12 teachers of science have been digging into the "Next Generation Science Standards" ("NGSS") (NGSS Lead States 2013) to begin creating plans and processes for translating them for classroom instruction. As teachers learn about the NGSS, they have asked about the general structure of the standards document and how to read…

  3. The Next Generation Science Standards: The Features and Challenges

    Science.gov (United States)

    Pruitt, Stephen L.

    2014-01-01

    Beginning in January of 2010, the Carnegie Corporation of New York funded a two-step process to develop a new set of state developed science standards intended to prepare students for college and career readiness in science. These new internationally benchmarked science standards, the Next Generation Science Standards (NGSS) were completed in…

  4. The Next Generation Science Standards: A Focus on Physical Science

    Science.gov (United States)

    Krajcik, Joe

    2013-01-01

    This article describes ways to adapt U.S. science curriculum to the U.S. National Research Council (NRC) "Framework for K-12 Science Education" and "Next Generation of Science Standards" (NGSS), noting their focus on teaching the physical sciences. The overall goal of the Framework and NGSS is to help all learners develop the…

  5. NGSS and the Next Generation of Science Teachers

    Science.gov (United States)

    Bybee, Rodger W.

    2014-01-01

    This article centers on the "Next Generation Science Standards" (NGSS) and their implications for teacher development, particularly at the undergraduate level. After an introduction to NGSS and the influence of standards in the educational system, the article addresses specific educational shifts--interconnecting science and engineering…

  6. Next Generation Science Standards: Adoption and Implementation Workbook

    Science.gov (United States)

    Peltzman, Alissa; Rodriguez, Nick

    2013-01-01

    The Next Generation Science Standards (NGSS) represent the culmination of years of collaboration and effort by states, science educators and experts from across the United States. Based on the National Research Council's "A Framework for K-12 Science Education" and developed in partnership with 26 lead states, the NGSS, when…

  7. Framework for Leading Next Generation Science Standards Implementation

    Science.gov (United States)

    Stiles, Katherine; Mundry, Susan; DiRanna, Kathy

    2017-01-01

    In response to the need to develop leaders to guide the implementation of the Next Generation Science Standards (NGSS), the Carnegie Corporation of New York provided funding to WestEd to develop a framework that defines the leadership knowledge and actions needed to effectively implement the NGSS. The development of the framework entailed…

  8. ERP II: Next-generation Extended Enterprise Resource Planning

    DEFF Research Database (Denmark)

    Møller, Charles

    2004-01-01

    ERP II (ERP/2) systems is a new concept introduced by Gartner Group in 2000 in order to label the latest extensions of the ERP-systems. The purpose of this paper is to explore the next-generation of ERP systems, the Extended Enterprise Resource Planning (EERP or as we prefer to use: e...

  9. Microbial production of next-generation stevia sweeteners

    DEFF Research Database (Denmark)

    Olsson, Kim; Carlsen, Simon; Semmler, Angelika

    2016-01-01

    BACKGROUND: The glucosyltransferase UGT76G1 from Stevia rebaudiana is a chameleon enzyme in the targeted biosynthesis of the next-generation premium stevia sweeteners, rebaudioside D (Reb D) and rebaudioside M (Reb M). These steviol glucosides carry five and six glucose units, respectively...

  10. Next Generation Sequencing at the University of Chicago Genomics Core

    Energy Technology Data Exchange (ETDEWEB)

    Faber, Pieter [University of Chicago

    2013-04-24

    The University of Chicago Genomics Core provides University of Chicago investigators (and external clients) access to State-of-the-Art genomics capabilities: next generation sequencing, Sanger sequencing / genotyping and micro-arrays (gene expression, genotyping, and methylation). The current presentation will highlight our capabilities in the area of ultra-high throughput sequencing analysis.

  11. Quality Search Content: A Reality With Next Generation Browsers

    Digital Repository Service at National Institute of Oceanography (India)

    Lakshminarayana, S.

    moderate user is browsing through at the most 30 to 40 links out of the total delivery set from a search engine. Next Generation browsers are to reach the user with intelligence to address issues related the content filtering, address blocking, user...

  12. The contribution of next generation sequencing to epilepsy genetics

    DEFF Research Database (Denmark)

    Møller, Rikke S.; Dahl, Hans A.; Helbig, Ingo

    2015-01-01

    to as epileptic encephalopathies. The increased knowledge about causative genetic variants has had a major impact on diagnosis of genetic epilepsies and has already been translated into treatment recommendations for a few genes. This article provides an overview of how next generation sequencing has advanced our...

  13. Modelling of control system architecture for next-generation accelerators

    International Nuclear Information System (INIS)

    Liu, Shi-Yao; Kurokawa, Shin-ichi

    1990-01-01

    Functional, hardware and software system architectures define the fundamental structure of control systems. Modelling is a protocol of system architecture used in system design. This paper reviews various modellings adopted in past ten years and suggests a new modelling for next generation accelerators. (author)

  14. A Novel Architecture for Next Generation Context- Aware Systems

    African Journals Online (AJOL)

    user1

    Furthermore, a novel architecture, C-. Arc, is proposed to aid in the development of the next generation context-aware systems. A prototype implemented of C-Arc is also presented to demonstrate the architecture. C-Arc provides support for most of the tasks involved in dealing with context, namely acquiring context.

  15. Clipboard: Brain–muscle interface: The next-generation BMI

    Indian Academy of Sciences (India)

    2011-05-16

    muscle interface: The next-generation BMI. Radhika Rajan Neeraj Jain. Volume 36 Issue 2 June 2011 pp 201-203. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/jbsc/036/02/0201- ...

  16. Next-Generation Model-based Variability Management: Languages and Tools

    OpenAIRE

    Acher , Mathieu; Heymans , Patrick; Collet , Philippe; Lahire , Philippe

    2012-01-01

    International audience; Variability modelling and management is a key activity in a growing number of software engineering contexts, from software product lines to dynamic adaptive systems. Feature models are the defacto standard to formally represent and reason about commonality and variability of a software system. This tutorial aims at presenting next generation of feature modelling languages and tools, directly applicable to a wide range of model-based variability problems and application...

  17. Advanced Combustion Systems for Next Generation Gas Turbines

    Energy Technology Data Exchange (ETDEWEB)

    Joel Haynes; Jonathan Janssen; Craig Russell; Marcus Huffman

    2006-01-01

    Next generation turbine power plants will require high efficiency gas turbines with higher pressure ratios and turbine inlet temperatures than currently available. These increases in gas turbine cycle conditions will tend to increase NOx emissions. As the desire for higher efficiency drives pressure ratios and turbine inlet temperatures ever higher, gas turbines equipped with both lean premixed combustors and selective catalytic reduction after treatment eventually will be unable to meet the new emission goals of sub-3 ppm NOx. New gas turbine combustors are needed with lower emissions than the current state-of-the-art lean premixed combustors. In this program an advanced combustion system for the next generation of gas turbines is being developed with the goal of reducing combustor NOx emissions by 50% below the state-of-the-art. Dry Low NOx (DLN) technology is the current leader in NOx emission technology, guaranteeing 9 ppm NOx emissions for heavy duty F class gas turbines. This development program is directed at exploring advanced concepts which hold promise for meeting the low emissions targets. The trapped vortex combustor is an advanced concept in combustor design. It has been studied widely for aircraft engine applications because it has demonstrated the ability to maintain a stable flame over a wide range of fuel flow rates. Additionally, it has shown significantly lower NOx emission than a typical aircraft engine combustor and with low CO at the same time. The rapid CO burnout and low NOx production of this combustor made it a strong candidate for investigation. Incremental improvements to the DLN technology have not brought the dramatic improvements that are targeted in this program. A revolutionary combustor design is being explored because it captures many of the critical features needed to significantly reduce emissions. Experimental measurements of the combustor performance at atmospheric conditions were completed in the first phase of the program

  18. Integrated Modeling for the Next Generation Space Telescope "Yardstick" Concept

    Science.gov (United States)

    Mosier, Gary E.; Broduer, Steve (Technical Monitor)

    2001-01-01

    The so-called NASA "Yardstick" design concept for the Next Generation Space Telescope presents unique challenges for systems-level analysis. Simulations that integrate controls, optics, thermal, and structural models are required to evaluate baseline performance, study design sensitivities, and perform design optimization. An integrated modeling approach was chosen using a combination of commercial off-the-shelf and "in-house" developed codes. The resulting capability provides a foundation for linear and non-linear analysis, using both the time and frequency-domain methods. It readily allows various combinations of design parameters and environmental loads to be evaluated directly in terms of key science-related metrics, in this case the scalar RMS (root mean square) line-of-sight and RMS wavefront errors. This presentation first addresses the development of the component, or discipline, models for the Yardstick design. It will then proceed to present the integration of the component models, using linear-systems approaches, in order to support two of the most critical baseline performance analyses: jitter and thermal-elastic stability of the optical telescope assembly (OTA). The results of the jitter analysis indicate that disturbances from the reaction wheels coupled with the lightly-damped and highly-flexible structure present significant challenges to the baseline line-of-sight control architecture. Vibration isolation will be required to meet jitter error requirements. The results of the thermal-elastic analysis indicate that the mirror segment displacements due to ground-to-orbit cool-down of the telescope are within the expected capture range of the segment rigid-body control actuators. This means we will be able to align and phase the primary mirror. However, the results for the analysis of the thermal transient response following an attitude maneuver (slew) show that this telescope design is not sufficiently stable, passively, to meet the wavefront error

  19. Architectural and Algorithmic Requirements for a Next-Generation System Analysis Code

    Energy Technology Data Exchange (ETDEWEB)

    V.A. Mousseau

    2010-05-01

    This document presents high-level architectural and system requirements for a next-generation system analysis code (NGSAC) to support reactor safety decision-making by plant operators and others, especially in the context of light water reactor plant life extension. The capabilities of NGSAC will be different from those of current-generation codes, not only because computers have evolved significantly in the generations since the current paradigm was first implemented, but because the decision-making processes that need the support of next-generation codes are very different from the decision-making processes that drove the licensing and design of the current fleet of commercial nuclear power reactors. The implications of these newer decision-making processes for NGSAC requirements are discussed, and resulting top-level goals for the NGSAC are formulated. From these goals, the general architectural and system requirements for the NGSAC are derived.

  20. Genomic and Functional Characteristics of Human Cytomegalovirus Revealed by Next-Generation Sequencing

    Directory of Open Access Journals (Sweden)

    Steven Sijmons

    2014-03-01

    Full Text Available The complete genome of human cytomegalovirus (HCMV was elucidated almost 25 years ago using a traditional cloning and Sanger sequencing approach. Analysis of the genetic content of additional laboratory and clinical isolates has lead to a better, albeit still incomplete, definition of the coding potential and diversity of wild-type HCMV strains. The introduction of a new generation of massively parallel sequencing technologies, collectively called next-generation sequencing, has profoundly increased the throughput and resolution of the genomics field. These increased possibilities are already leading to a better understanding of the circulating diversity of HCMV clinical isolates. The higher resolution of next-generation sequencing provides new opportunities in the study of intrahost viral population structures. Furthermore, deep sequencing enables novel diagnostic applications for sensitive drug resistance mutation detection. RNA-seq applications have changed the picture of the HCMV transcriptome, which resulted in proof of a vast amount of splicing events and alternative transcripts. This review discusses the application of next-generation sequencing technologies, which has provided a clearer picture of the intricate nature of the HCMV genome. The continuing development and application of novel sequencing technologies will further augment our understanding of this ubiquitous, but elusive, herpesvirus.

  1. Genomic and Functional Characteristics of Human Cytomegalovirus Revealed by Next-Generation Sequencing

    Science.gov (United States)

    Sijmons, Steven; Van Ranst, Marc; Maes, Piet

    2014-01-01

    The complete genome of human cytomegalovirus (HCMV) was elucidated almost 25 years ago using a traditional cloning and Sanger sequencing approach. Analysis of the genetic content of additional laboratory and clinical isolates has lead to a better, albeit still incomplete, definition of the coding potential and diversity of wild-type HCMV strains. The introduction of a new generation of massively parallel sequencing technologies, collectively called next-generation sequencing, has profoundly increased the throughput and resolution of the genomics field. These increased possibilities are already leading to a better understanding of the circulating diversity of HCMV clinical isolates. The higher resolution of next-generation sequencing provides new opportunities in the study of intrahost viral population structures. Furthermore, deep sequencing enables novel diagnostic applications for sensitive drug resistance mutation detection. RNA-seq applications have changed the picture of the HCMV transcriptome, which resulted in proof of a vast amount of splicing events and alternative transcripts. This review discusses the application of next-generation sequencing technologies, which has provided a clearer picture of the intricate nature of the HCMV genome. The continuing development and application of novel sequencing technologies will further augment our understanding of this ubiquitous, but elusive, herpesvirus. PMID:24603756

  2. Next-generation genome-scale models for metabolic engineering

    DEFF Research Database (Denmark)

    King, Zachary A.; Lloyd, Colton J.; Feist, Adam M.

    2015-01-01

    Constraint-based reconstruction and analysis (COBRA) methods have become widely used tools for metabolic engineering in both academic and industrial laboratories. By employing a genome-scale in silico representation of the metabolic network of a host organism, COBRA methods can be used to predict...... optimal genetic modifications that improve the rate and yield of chemical production. A new generation of COBRA models and methods is now being developed. -. encompassing many biological processes and simulation strategies. -. and next-generation models enable new types of predictions. Here, three key...... examples of applying COBRA methods to strain optimization are presented and discussed. Then, an outlook is provided on the next generation of COBRA models and the new types of predictions they will enable for systems metabolic engineering....

  3. Alternative metro architectures for delivering next-generation data services

    Science.gov (United States)

    Parikh, Anand

    2002-08-01

    Data services are a primary target for increasing carrier revenues. As carriers prepare to capture this opportunity, they must determine how to cost-effectively deliver the more flexible and scalable bandwidth customers are requesting. Ethernet has emerged as a key technology for delivering these next-generation services; it is easy-to-use, widely understood and offers lower cost to both carriers and end customers. With more bandwidth available in the carrier core, the next challenge is the Metropolitan Area Network (MAN), where data services have been constrained by technologies optimized for voice services. This paper describes an Ethernet-over-SDH/SONET migration scenario that enables a portfolio of metro data services, such as Internet access and Virtual Private Lines, which can be delivered. It illustrates how optimizing SONET/SDH networks for next-generation data services will prove to be more cost-effective, scalable, manageable and resilient.

  4. Next-generation sequencing offers new insights into DNA degradation

    DEFF Research Database (Denmark)

    Overballe-Petersen, Søren; Orlando, Ludovic Antoine Alexandre; Willerslev, Eske

    2012-01-01

    The processes underlying DNA degradation are central to various disciplines, including cancer research, forensics and archaeology. The sequencing of ancient DNA molecules on next-generation sequencing platforms provides direct measurements of cytosine deamination, depurination and fragmentation...... rates that previously were obtained only from extrapolations of results from in vitro kinetic experiments performed over short timescales. For example, recent next-generation sequencing of ancient DNA reveals purine bases as one of the main targets of postmortem hydrolytic damage, through base...... elimination and strand breakage. It also shows substantially increased rates of DNA base-loss at guanosine. In this review, we argue that the latter results from an electron resonance structure unique to guanosine rather than adenosine having an extra resonance structure over guanosine as previously suggested....

  5. Emerging Definition of Next-Generation of Aeronautical Communications

    Science.gov (United States)

    Kerczewski, Robert J.

    2006-01-01

    Aviation continues to experience rapid growth. In regions such as the United States and Europe air traffic congestion is constraining operations, leading to major new efforts to develop methodologies and infrastructures to enable continued aviation growth through transformational air traffic management systems. Such a transformation requires better communications linking airborne and ground-based elements. Technologies for next-generation communications, the required capacities, frequency spectrum of operation, network interconnectivity, and global interoperability are now receiving increased attention. A number of major planning and development efforts have taken place or are in process now to define the transformed airspace of the future. These activities include government and industry led efforts in the United States and Europe, and by international organizations. This paper will review the features, approaches, and activities of several representative planning and development efforts, and identify the emerging global consensus on requirements of next generation aeronautical communications systems for air traffic control.

  6. Converged Wireless Networking and Optimization for Next Generation Services

    Directory of Open Access Journals (Sweden)

    J. Rodriguez

    2010-01-01

    Full Text Available The Next Generation Network (NGN vision is tending towards the convergence of internet and mobile services providing the impetus for new market opportunities in combining the appealing services of internet with the roaming capability of mobile networks. However, this convergence does not go far enough, and with the emergence of new coexistence scenarios, there is a clear need to evolve the current architecture to provide cost-effective end-to-end communication. The LOOP project, a EUREKA-CELTIC driven initiative, is one piece in the jigsaw by helping European industry to sustain a leading role in telecommunications and manufacturing of high-value products and machinery by delivering pioneering converged wireless networking solutions that can be successfully demonstrated. This paper provides an overview of the LOOP project and the key achievements that have been tunneled into first prototypes for showcasing next generation services for operators and process manufacturers.

  7. Investigation of a Canine Parvovirus Outbreak using Next Generation Sequencing

    OpenAIRE

    Parker, Jayme; Murphy, Molly; Hueffer, Karsten; Chen, Jack

    2017-01-01

    Canine parvovirus (CPV) outbreaks can have a devastating effect in communities with dense dog populations. The interior region of Alaska experienced a CPV outbreak in the winter of 2016 leading to the further investigation of the virus due to reports of increased morbidity and mortality occurring at dog mushing kennels in the area. Twelve rectal-swab specimens from dogs displaying clinical signs consistent with parvoviral-associated disease were processed using next-generation sequencing (NGS...

  8. Developing the next generation of nuclear workers at OPG

    International Nuclear Information System (INIS)

    Spekkens, P.

    2007-01-01

    This presentation is about developing the next generation of nuclear workers at Ontario Power Generation (OPG). Industry developments are creating urgent need to hire, train and retain new staff. OPG has an aggressive hiring campaign. Training organization is challenged to accommodate influx of new staff. Collaborating with colleges and universities is increasing the supply of qualified recruits with an interest in nuclear. Program for functional and leadership training have been developed. Knowledge retention is urgently required

  9. Connecting, Protecting, and Informing the Next Generation of First Responders

    Science.gov (United States)

    2015-12-10

    Protecting , and Informing the Next Generation of First Responders MIT Lincoln Laboratory is developing high-tech tools to improve situational awareness...responders in the field. For example, Lincoln’s NGFR-enhanced version of the mobile app utilizes the Sony Smart Eyeglass to take data from wearable sensors...Lincoln’s involvement with S&T’s NGFR Apex program is a prime example of the Laboratory’s homeland protection mission in action: creating prototypes

  10. The Next Generation Transit Survey Becomes Operational at Paranal

    Science.gov (United States)

    West, R. G.; Pollacco, D.; Wheatley, P.; Goad, M.; Queloz, D.; Rauer, H.; Watson, C.; Udry, S.; Bannister, N.; Bayliss, D.; Bouchy, F.; Burleigh, M.; Cabrera, J.; Chaushev, A.; Chazelas, B.; Crausaz, M.; Csizmadia, S.; Eigmüller, P.; Erikson, A.; Genolet, L.; Gillen, E.; Grange, A.; Günther, M.; Hodgkin, S.; Kirk, J.; Lambert, G.; Louden, T.; McCormac, J.; Metrailler, L.; Neveu, M.; Smith, A.; Thompson, A.; Raddi, R.; Walker, S. R.; Jenkins, J.; Jordán, A.

    2016-09-01

    A new facility dedicated to the discovery of exoplanets has commenced science operations at Paranal. The Next-Generation Transit Survey (NGTS) will deliver photometry at a precision unprecedented for a ground-based wide-field survey, enabling the discovery of dozens of transiting exoplanets of the size of Neptune or smaller around bright stars. NGTS is briefly described and the survey prospects are outlined.

  11. NREL Next Generation Drivetrain: Mechanical Design and Test Plan (Poster)

    Energy Technology Data Exchange (ETDEWEB)

    Keller, J.; Halse, C.

    2014-05-01

    The Department of Energy and industry partners are sponsoring a $3m project for design and testing of a 'Next Generation' wind turbine drivetrain at the National Renewable Energy Laboratory (NREL). This poster focuses on innovative aspects of the gearbox design, completed as part of an end-to-end systems engineering approach incorporating innovations that increase drivetrain reliability, efficiency, torque density and minimize capital cost.

  12. Autonomous energy management system in next generation homes

    OpenAIRE

    Charro Laiño, Raúl

    2012-01-01

    [ANGLÈS] The energy management system in next generation home has been developed in web semantic technology. This technology is used in smart homes. And for the monitoring of the power level and consumption of appliances, groups and rooms. Inside the autonomous energy system. The semantic web will give us the necessary interrelated to use autonomous. For good management of energy consumption, we must create communication methods to interact with the user. We can refer to the possibilities off...

  13. The next generation of power reactors - safety characteristics

    International Nuclear Information System (INIS)

    Modro, S.M.

    1995-01-01

    The next generation of commercial nuclear power reactors is characterized by a new approach to achieving reliability of their safety systems. In contrast to current generation reactors, these designs apply passive safety features that rely on gravity-driven transfer processes or stored energy, such as gas-pressurized accumulators or electric batteries. This paper discusses the passive safety system of the AP600 and Simplified Boiling Water Reactor (SBWR) designs

  14. NNSA Program Develops the Next Generation of Nuclear Security Experts

    Energy Technology Data Exchange (ETDEWEB)

    Brim, Cornelia P.; Disney, Maren V.

    2015-09-02

    NNSA is fostering the next generation of nuclear security experts is through its successful NNSA Graduate Fellowship Program (NGFP). NGFP offers its Fellows an exceptional career development opportunity through hands-on experience supporting NNSA mission areas across policy and technology disciplines. The one-year assignments give tomorrow’s leaders in global nuclear security and nonproliferation unparalleled exposure through assignments to Program Offices across NNSA.

  15. Development and Efficacy Testing of Next Generation Cyanide Antidotes

    Science.gov (United States)

    2013-10-01

    LC-MS/MS Analysis of 2-Aminothiazoline-4-Carboxylic Acid as a Forensic Biomarker for Cyanide Poisoning . Journal of World Methodology, 26, 2(5),1-7...Generation Cyanide Antidotes PRINCIPAL INVESTIGATOR: Ilona Petrikovics, Ph.D...Testing of Next Generation Cyanide Antidotes 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-12-2-0126 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Ilona

  16. Next-generation in-situ science concepts and technology

    Science.gov (United States)

    Muirhead, Brian; Varsi, Giulio

    1990-01-01

    This paper discusses the concepts of a next-generation in situ science program, named Sample Acquisition, Analysis, and Preservation (SAAP), established by NASA to develop critical technologies for remote identification, acquisition, processing, analysis, and preservation of materials for the in situ science, engineering characterization, and earth return. Special attention is given to the SAAP architecture, system design, remote sensing system, sample acquisition system, and methods for sample analysis. A diagram of the SAAP preliminary system conceptual design is included.

  17. Next Generation Qualification: Nanometrics T120PH Seismometer Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Merchant, Bion J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Slad, George William [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-10-01

    Sandia National Laboratories has tested and evaluated three seismometers, the Trillium 120PH, manufactured by Nanometrics. These seismometers measure broadband ground velocity using a UVW configuration with feedback control in a mechanically levelled borehole package. The purpose of the seismometer evaluation was to determine a measured sensitivity, response, self- noise, dynamic range, and self-calibration ability. The Nanometrics Trillium 120PH seismometers are being evaluated for the U.S. Air Force as part of their Next Generation Qualification effort.

  18. Configuring next generation food supply chains: a risk perspective

    OpenAIRE

    Deep, Aman; Dani, Samir

    2010-01-01

    An often overlooked aspect of today’s business environment in general and supply chains in particular is uncertainty. The scenarios of loss of supplier, transport strikes, IT services failing, stock outs etc are becoming all too common. Looking at the future of supply\\ud chains, uncertainty and risk appear to be increasing and will play a crucial part in the configuration of next generation supply chain. This paper presents an alternative approach to supply chain configuration using supply ch...

  19. TriG: Next Generation Scalable Spaceborne GNSS Receiver

    Science.gov (United States)

    Tien, Jeffrey Y.; Okihiro, Brian Bachman; Esterhuizen, Stephan X.; Franklin, Garth W.; Meehan, Thomas K.; Munson, Timothy N.; Robison, David E.; Turbiner, Dmitry; Young, Lawrence E.

    2012-01-01

    TriG is the next generation NASA scalable space GNSS Science Receiver. It will track all GNSS and additional signals (i.e. GPS, GLONASS, Galileo, Compass and Doris). Scalable 3U architecture and fully software and firmware recofigurable, enabling optimization to meet specific mission requirements. TriG GNSS EM is currently undergoing testing and is expected to complete full performance testing later this year.

  20. Identification of Hepatitis C Virus Transmission Using a Next-Generation Sequencing Approach

    Science.gov (United States)

    Escobar-Gutiérrez, Alejandro; Vazquez-Pichardo, Mauricio; Cruz-Rivera, Mayra; Rivera-Osorio, Pilar; Carpio-Pedroza, Juan Carlos; Ruíz-Pacheco, Juan Alberto; Ruiz-Tovar, Karina

    2012-01-01

    Here, we describe a transmission event of hepatitis C virus (HCV) among injection drug users. Next-generation sequencing (NGS) was used to assess the intrahost viral genetic variation. Deep amplicon sequencing of HCV hypervariable region 1 allowed for a detailed analysis of the structure of the viral population. Establishment of the genetic relatedness between cases was accomplished by phylogenetic analysis. NGS is a powerful tool with applications in molecular epidemiology studies and outbreak investigations. PMID:22301026

  1. Identification of Hepatitis C Virus Transmission Using a Next-Generation Sequencing Approach

    OpenAIRE

    Escobar-Gutiérrez, Alejandro; Vazquez-Pichardo, Mauricio; Cruz-Rivera, Mayra; Rivera-Osorio, Pilar; Carpio-Pedroza, Juan Carlos; Ruíz-Pacheco, Juan Alberto; Ruiz-Tovar, Karina; Vaughan, Gilberto

    2012-01-01

    Here, we describe a transmission event of hepatitis C virus (HCV) among injection drug users. Next-generation sequencing (NGS) was used to assess the intrahost viral genetic variation. Deep amplicon sequencing of HCV hypervariable region 1 allowed for a detailed analysis of the structure of the viral population. Establishment of the genetic relatedness between cases was accomplished by phylogenetic analysis. NGS is a powerful tool with applications in molecular epidemiology studies and outbre...

  2. From next-generation sequencing to systematic modeling of the gut microbiome

    OpenAIRE

    Ji, Boyang; Nielsen, Jens

    2015-01-01

    Changes in the human gut microbiome are associated with altered human metabolism and health, yet the mechanisms of interactions between microbial species and human metabolism have not been clearly elucidated. Next-generation sequencing has revolutionized the human gut microbiome research, but most current applications concentrate on studying the microbial diversity of communities and have at best provided associations between specific gut bacteria and human health. However, little is known ab...

  3. Expectations for the next generation of electronic patient records in primary care: a triangulated study

    Directory of Open Access Journals (Sweden)

    Tom Christensen

    2008-05-01

    Conclusions Progress toward a problem-oriented EPR system based on episodes of care that includes decision support is necessary to satisfy the needs expressed by GPs. Further research could solve the problem of integration of functionality for consultation with specialists and integration with patient held records. Results from this study could contribute to further development of the next generation of EPRs in primary care, as well as inspire the application of EPRs in other parts of the health sector.

  4. USE OF NEXT-GENERATION SEQUENCING FOR GENOMIC ANALYSIS IN COMPLEX DISEASES

    OpenAIRE

    Sana, Maria Elena

    2013-01-01

    Since the early 1990s, Sanger method has been the gold standard methodology for sequencing analysis of DNA. Next-generation sequencing (NGS) approaches revolutionized the field of genomics over the last 5 years. These new sequencing technologies make feasible the direct and cost-effective sequencing of genomes at unprecedented scale and speed. Furthermore, the applications of these technologies are wide-spread and have been developed to explore the complex biological systems, among which RNA ...

  5. Next-Generation Sequencing of Tubal Intraepithelial Carcinomas.

    Science.gov (United States)

    McDaniel, Andrew S; Stall, Jennifer N; Hovelson, Daniel H; Cani, Andi K; Liu, Chia-Jen; Tomlins, Scott A; Cho, Kathleen R

    2015-11-01

    High-grade serous carcinoma (HGSC) is the most prevalent and lethal form of ovarian cancer. HGSCs frequently arise in the distal fallopian tubes rather than the ovary, developing from small precursor lesions called serous tubal intraepithelial carcinomas (TICs, or more specifically, STICs). While STICs have been reported to harbor TP53 mutations, detailed molecular characterizations of these lesions are lacking. We performed targeted next-generation sequencing (NGS) on formalin-fixed, paraffin-embedded tissue from 4 women, 2 with HGSC and 2 with uterine endometrioid carcinoma (UEC) who were diagnosed as having synchronous STICs. We detected concordant mutations in both HGSCs with synchronous STICs, including TP53 mutations as well as assumed germline BRCA1/2 alterations, confirming a clonal association between these lesions. Next-generation sequencing confirmed the presence of a STIC clonally unrelated to 1 case of UEC, and NGS of the other tubal lesion diagnosed as a STIC unexpectedly supported the lesion as a micrometastasis from the associated UEC. We demonstrate that targeted NGS can identify genetic alterations in minute lesions, such as TICs, and confirm TP53 mutations as early driving events for HGSC. Next-generation sequencing also demonstrated unexpected associations between presumed STICs and synchronous carcinomas, providing evidence that some TICs are actually metastases rather than HGSC precursors.

  6. Next generation sequencing in sporadic retinoblastoma patients reveals somatic mosaicism.

    Science.gov (United States)

    Amitrano, Sara; Marozza, Annabella; Somma, Serena; Imperatore, Valentina; Hadjistilianou, Theodora; De Francesco, Sonia; Toti, Paolo; Galimberti, Daniela; Meloni, Ilaria; Cetta, Francesco; Piu, Pietro; Di Marco, Chiara; Dosa, Laura; Lo Rizzo, Caterina; Carignani, Giulia; Mencarelli, Maria Antonietta; Mari, Francesca; Renieri, Alessandra; Ariani, Francesca

    2015-11-01

    In about 50% of sporadic cases of retinoblastoma, no constitutive RB1 mutations are detected by conventional methods. However, recent research suggests that, at least in some of these cases, there is somatic mosaicism with respect to RB1 normal and mutant alleles. The increased availability of next generation sequencing improves our ability to detect the exact percentage of patients with mosaicism. Using this technology, we re-tested a series of 40 patients with sporadic retinoblastoma: 10 of them had been previously classified as constitutional heterozygotes, whereas in 30 no RB1 mutations had been found in lymphocytes. In 3 of these 30 patients, we have now identified low-level mosaic variants, varying in frequency between 8 and 24%. In 7 out of the 10 cases previously classified as heterozygous from testing blood cells, we were able to test additional tissues (ocular tissues, urine and/or oral mucosa): in three of them, next generation sequencing has revealed mosaicism. Present results thus confirm that a significant fraction (6/40; 15%) of sporadic retinoblastoma cases are due to postzygotic events and that deep sequencing is an efficient method to unambiguously distinguish mosaics. Re-testing of retinoblastoma patients through next generation sequencing can thus provide new information that may have important implications with respect to genetic counseling and family care.

  7. Selection of Digital Subscriber Lines Ready for Next Generation Access

    Directory of Open Access Journals (Sweden)

    Petr Jares

    2015-01-01

    Full Text Available Nowadays, in the EU a lot of project concerning broadband access to the Internet for end users is being developed. The aim of those projects is to support the creation of access communication networks that can meet defined performance criteria for providing the broadband services. Such networks are in general called Next Generation Access. One of the first tasks is to identify appropriate transmission technologies that could meet the required performance criteria. For each transmission technology, it is necessary to carry out a detailed performance analysis of the transmission depending on certain transmission conditions. To perform a detailed analysis means to carry out modelling of transmission’s specific conditions for each technology. This article, specifically, discusses hybrid optical networks, which in conjunction with digital subscriber lines are one of the possible solutions for Next Generation Access. In the access network topology that combines copper and optical cables, it is necessary to optimize the mutual ratio of both infrastructure’s length. Therefore, the article also describes this issue that refers to a certain technology for the Next Generation Access. Specific performance criteria of transmission for access network in the Czech Republic are considered and the optimized location of the external node digital line access multiplexer is discussed.

  8. Mobility management techniques for the next-generation wireless networks

    Science.gov (United States)

    Sun, Junzhao; Howie, Douglas P.; Sauvola, Jaakko J.

    2001-10-01

    The tremendous demands from social market are pushing the booming development of mobile communications faster than ever before, leading to plenty of new advanced techniques emerging. With the converging of mobile and wireless communications with Internet services, the boundary between mobile personal telecommunications and wireless computer networks is disappearing. Wireless networks of the next generation need the support of all the advances on new architectures, standards, and protocols. Mobility management is an important issue in the area of mobile communications, which can be best solved at the network layer. One of the key features of the next generation wireless networks is all-IP infrastructure. This paper discusses the mobility management schemes for the next generation mobile networks through extending IP's functions with mobility support. A global hierarchical framework model for the mobility management of wireless networks is presented, in which the mobility management is divided into two complementary tasks: macro mobility and micro mobility. As the macro mobility solution, a basic principle of Mobile IP is introduced, together with the optimal schemes and the advances in IPv6. The disadvantages of the Mobile IP on solving the micro mobility problem are analyzed, on the basis of which three main proposals are discussed as the micro mobility solutions for mobile communications, including Hierarchical Mobile IP (HMIP), Cellular IP, and Handoff-Aware Wireless Access Internet Infrastructure (HAWAII). A unified model is also described in which the different micro mobility solutions can coexist simultaneously in mobile networks.

  9. Next Generation Bipolar Plates for Automotive PEM Fuel Cells

    Energy Technology Data Exchange (ETDEWEB)

    Adrianowycz, Orest; Norley, Julian; Stuart, David J; Flaherty, David; Wayne, Ryan; ; Williams, Warren; Tietze, Roger; Nguyen, Yen-Loan H; Zawodzinski, Tom; Pietrasz, Patrick

    2010-04-15

    The results of a successful U.S. Department of Energy (DoE) funded two-year $2.9 MM program lead by GrafTech International Inc. (GrafTech) are reported and summarized. The program goal was to develop the next generation of high temperature proton exchange membrane (PEM) fuel cell bipolar plates for use in transportation fuel cell applications operating at temperatures up to 120 °C. The bipolar plate composite developed during the program is based on GrafTech’s GRAFCELL resin impregnated flexible graphite technology and makes use of a high temperature Huntsman Advanced Materials resin system which extends the upper use temperature of the composite to the DoE target. High temperature performance of the new composite is achieved with the added benefit of improvements in strength, modulus, and dimensional stability over the incumbent resin systems. Other physical properties, including thermal and electrical conductivity of the new composite are identical to or not adversely affected by the new resin system. Using the new bipolar plate composite system, machined plates were fabricated and tested in high temperature single-cell fuel cells operating at 120 °C for over 1100 hours by Case Western Reserve University. Final verification of performance was done on embossed full-size plates which were fabricated and glued into bipolar plates by GrafTech. Stack testing was done on a 10-cell full-sized stack under a simulated drive cycle protocol by Ballard Power Systems. Freeze-thaw performance was conducted by Ballard on a separate 5-cell stack and shown to be within specification. A third stack was assembled and shipped to Argonne National Laboratory for independent performance verification. Manufacturing cost estimate for the production of the new bipolar plate composite at current and high volume production scenarios was performed by Directed Technologies Inc. (DTI). The production cost estimates were consistent with previous DoE cost estimates performed by DTI for the

  10. Next generation framework for aquatic modeling of the Earth System

    Science.gov (United States)

    Fekete, B. M.; Wollheim, W. M.; Wisser, D.; Vörösmarty, C. J.

    2009-03-01

    Earth System model development is becoming an increasingly complex task. As scientists attempt to represent the physical and bio-geochemical processes and various feedback mechanisms in unprecedented detail, the models themselves are becoming increasingly complex. At the same time, the complexity of the surrounding IT infrastructure is growing as well. Earth System models must manage a vast amount of data in heterogeneous computing environments. Numerous development efforts are on the way to ease that burden and offer model development platforms that reduce IT challenges and allow scientists to focus on their science. While these new modeling frameworks (e.g. FMS, ESMF, CCA, OpenMI) do provide solutions to many IT challenges (performing input/output, managing space and time, establishing model coupling, etc.), they are still considerably complex and often have steep learning curves. The Next generation Framework for Aquatic Modeling of the Earth System (NextFrAMES, a revised version of FrAMES) have numerous similarities to those developed by other teams, but represents a novel model development paradigm. NextFrAMES is built around a modeling XML that lets modelers to express the overall model structure and provides an API for dynamically linked plugins to represent the processes. The model XML is executed by the NextFrAMES run-time engine that parses the model definition, loads the module plugins, performs the model I/O and executes the model calculations. NextFrAMES has a minimalistic view representing spatial domains and treats every domain (regardless of its layout such as grid, network tree, individual points, polygons, etc.) as vector of objects. NextFrAMES performs computations on multiple domains and interactions between different spatial domains are carried out through couplers. NextFrAMES allows processes to operate at different frequencies by providing rudimentary aggregation and disaggregation facilities. NextFrAMES was designed primarily for

  11. SMITH: a LIMS for handling next-generation sequencing workflows

    Science.gov (United States)

    2014-01-01

    Background Life-science laboratories make increasing use of Next Generation Sequencing (NGS) for studying bio-macromolecules and their interactions. Array-based methods for measuring gene expression or protein-DNA interactions are being replaced by RNA-Seq and ChIP-Seq. Sequencing is generally performed by specialized facilities that have to keep track of sequencing requests, trace samples, ensure quality and make data available according to predefined privileges. An integrated tool helps to troubleshoot problems, to maintain a high quality standard, to reduce time and costs. Commercial and non-commercial tools called LIMS (Laboratory Information Management Systems) are available for this purpose. However, they often come at prohibitive cost and/or lack the flexibility and scalability needed to adjust seamlessly to the frequently changing protocols employed. In order to manage the flow of sequencing data produced at the Genomic Unit of the Italian Institute of Technology (IIT), we developed SMITH (Sequencing Machine Information Tracking and Handling). Methods SMITH is a web application with a MySQL server at the backend. Wet-lab scientists of the Centre for Genomic Science and database experts from the Politecnico of Milan in the context of a Genomic Data Model Project developed SMITH. The data base schema stores all the information of an NGS experiment, including the descriptions of all protocols and algorithms used in the process. Notably, an attribute-value table allows associating an unconstrained textual description to each sample and all the data produced afterwards. This method permits the creation of metadata that can be used to search the database for specific files as well as for statistical analyses. Results SMITH runs automatically and limits direct human interaction mainly to administrative tasks. SMITH data-delivery procedures were standardized making it easier for biologists and analysts to navigate the data. Automation also helps saving time. The

  12. What can next generation sequencing do for you? Next generation sequencing as a valuable tool in plant research

    OpenAIRE

    Bräutigam, Andrea; Gowik, Udo

    2010-01-01

    Next generation sequencing (NGS) technologies have opened fascinating opportunities for the analysis of plants with and without a sequenced genome on a genomic scale. During the last few years, NGS methods have become widely available and cost effective. They can be applied to a wide variety of biological questions, from the sequencing of complete eukaryotic genomes and transcriptomes, to the genome-scale analysis of DNA-protein interactions. In this review, we focus on the use of NGS for pla...

  13. Advances in clinical next-generation sequencing: target enrichment and sequencing technologies.

    Science.gov (United States)

    Ballester, Leomar Y; Luthra, Rajyalakshmi; Kanagal-Shamanna, Rashmi; Singh, Rajesh R

    2016-01-01

    The huge parallel sequencing capabilities of next generation sequencing technologies have made them the tools of choice to characterize genomic aberrations for research and diagnostic purposes. For clinical applications, screening the whole genome or exome is challenging owing to the large genomic area to be sequenced, associated costs, complexity of data, and lack of known clinical significance of all genes. Consequently, routine screening involves limited markers with established clinical relevance. This process, referred to as targeted genome sequencing, requires selective enrichment of the genomic areas comprising these markers via one of several primer or probe-based enrichment strategies, followed by sequencing of the enriched genomic areas. Here, the authors review current target enrichment approaches and next generation sequencing platforms, focusing on the underlying principles, capabilities, and limitations of each technology along with validation and implementation for clinical testing.

  14. Standards of Evidence for Efficacy, Effectiveness, and Scale-up Research in Prevention Science: Next Generation.

    Science.gov (United States)

    Gottfredson, Denise C; Cook, Thomas D; Gardner, Frances E M; Gorman-Smith, Deborah; Howe, George W; Sandler, Irwin N; Zafft, Kathryn M

    2015-10-01

    A decade ago, the Society of Prevention Research (SPR) endorsed a set of standards for evidence related to research on prevention interventions. These standards (Flay et al., Prevention Science 6:151-175, 2005) were intended in part to increase consistency in reviews of prevention research that often generated disparate lists of effective interventions due to the application of different standards for what was considered to be necessary to demonstrate effectiveness. In 2013, SPR's Board of Directors decided that the field has progressed sufficiently to warrant a review and, if necessary, publication of "the next generation" of standards of evidence. The Board convened a committee to review and update the standards. This article reports on the results of this committee's deliberations, summarizing changes made to the earlier standards and explaining the rationale for each change. The SPR Board of Directors endorses "The Standards of Evidence for Efficacy, Effectiveness, and Scale-up Research in Prevention Science: Next Generation."

  15. Next-Generation Bio-Products Sowing the Seeds of Success for Sustainable Agriculture

    Directory of Open Access Journals (Sweden)

    Henry Müller

    2013-10-01

    Full Text Available Plants have recently been recognized as meta-organisms due to a close symbiotic relationship with their microbiome. Comparable to humans and other eukaryotic hosts, plants also harbor a “second genome” that fulfills important host functions. These advances were driven by both “omics”-technologies guided by next-generation sequencing and microscopic insights. Additionally, these new results influence applied fields such as biocontrol and stress protection in agriculture, and new tools may impact (i the detection of new bio-resources for biocontrol and plant growth promotion, (ii the optimization of fermentation and formulation processes for biologicals, (iii stabilization of the biocontrol effect under field conditions, and (iv risk assessment studies for biotechnological applications. Examples are presented and discussed for the fields mentioned above, and next-generation bio-products were found as a sustainable alternative for agriculture.

  16. Report on achievement in developing an ultra low loss power element technology. Survey on practical application of the next generation power semiconductor devices; 1998 nendo choteisonshitsu denryoku soshi gijutsu kaihatsu seika hokokusho. Jisedai power handotai device jitsuyoka chosa

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-01

    Trends were surveyed for development of an ultra low loss power element. Performance improvement has been progressed on power semiconductor elements by using Si as the raw material, but loss reduction has come close to the physical limit. SiC is expected of possibility to go beyond this limit. SiC is so very excellent that its band gap is two to three times greater, insulation breakdown electric field is 7.5 times higher, temperature to become a true semiconductor is three to four times higher than those of Si. The wide gap can reduce high temperature leaking current in p-n junctions, and the increased authenticity temperature can increase the upper limit for operation temperature. The insulation breakdown strength being higher by one digit can reduce the drift layer thickness, and is expected to dramatically reduce the loss. The problem is that high quality crystals have not been obtained to date. One of the promising application fields is electric vehicle. The device currently using the power element in the largest scale is used in frequency converting stations to link the 50-Hz power network in the eastern part of Japan to the 60-Hz network in the western part of Japan. Surveys were carried out on the Sakuma frequency converting station and the New Shinano substation. (NEDO)

  17. Challenges and opportunities in estimating viral genetic diversity from next-generation sequencing data

    Directory of Open Access Journals (Sweden)

    Niko eBeerenwinkel

    2012-09-01

    Full Text Available Many viruses, including the clinically relevant RNA viruses HIV and HCV, exist in large populations and display high genetic heterogeneity within and between infected hosts. Assessing intra-patient viral genetic diversity is essential for understanding the evolutionary dynamics of viruses, for designing effective vaccines, and for the success of antiviral therapy. Next-generation sequencing technologies allow the rapid and cost-effective acquisition of thousands to millions of short DNA sequences from a single sample. However, this approach entails several challenges in experimental design and computational data analysis. Here, we review the entire process of inferring viral diversity from sample collection to computing measures of genetic diversity. We discuss sample preparation, including reverse transcription and amplification, and the effect of experimental conditions on diversity estimates due to in vitro base substitutions, insertions, deletions, and recombination. The use of different next-generation sequencing platforms and their sequencing error profiles are compared in the context of various applications of diversity estimation, ranging from the detection of single nucleotide variants to the reconstruction of whole-genome haplotypes. We describe the statistical and computational challenges arising from these technical artifacts, and we review existing approaches, including available software, for their solution. Finally, we discuss open problems, and highlight successful biomedical applications and potential future clinical use of next-generation sequencing to estimate viral diversity.

  18. Evaluating multiplexed next-generation sequencing as a method in palynology for mixed pollen samples.

    Science.gov (United States)

    Keller, A; Danner, N; Grimmer, G; Ankenbrand, M; von der Ohe, K; von der Ohe, W; Rost, S; Härtel, S; Steffan-Dewenter, I

    2015-03-01

    The identification of pollen plays an important role in ecology, palaeo-climatology, honey quality control and other areas. Currently, expert knowledge and reference collections are essential to identify pollen origin through light microscopy. Pollen identification through molecular sequencing and DNA barcoding has been proposed as an alternative approach, but the assessment of mixed pollen samples originating from multiple plant species is still a tedious and error-prone task. Next-generation sequencing has been proposed to avoid this hindrance. In this study we assessed mixed pollen probes through next-generation sequencing of amplicons from the highly variable, species-specific internal transcribed spacer 2 region of nuclear ribosomal DNA. Further, we developed a bioinformatic workflow to analyse these high-throughput data with a newly created reference database. To evaluate the feasibility, we compared results from classical identification based on light microscopy from the same samples with our sequencing results. We assessed in total 16 mixed pollen samples, 14 originated from honeybee colonies and two from solitary bee nests. The sequencing technique resulted in higher taxon richness (deeper assignments and more identified taxa) compared to light microscopy. Abundance estimations from sequencing data were significantly correlated with counted abundances through light microscopy. Simulation analyses of taxon specificity and sensitivity indicate that 96% of taxa present in the database are correctly identifiable at the genus level and 70% at the species level. Next-generation sequencing thus presents a useful and efficient workflow to identify pollen at the genus and species level without requiring specialised palynological expert knowledge. © 2014 German Botanical Society and The Royal Botanical Society of the Netherlands.

  19. Computational Needs for the Next Generation Electric Grid Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Birman, Kenneth; Ganesh, Lakshmi; Renessee, Robbert van; Ferris, Michael; Hofmann, Andreas; Williams, Brian; Sztipanovits, Janos; Hemingway, Graham; University, Vanderbilt; Bose, Anjan; Stivastava, Anurag; Grijalva, Santiago; Grijalva, Santiago; Ryan, Sarah M.; McCalley, James D.; Woodruff, David L.; Xiong, Jinjun; Acar, Emrah; Agrawal, Bhavna; Conn, Andrew R.; Ditlow, Gary; Feldmann, Peter; Finkler, Ulrich; Gaucher, Brian; Gupta, Anshul; Heng, Fook-Luen; Kalagnanam, Jayant R; Koc, Ali; Kung, David; Phan, Dung; Singhee, Amith; Smith, Basil

    2011-10-05

    The April 2011 DOE workshop, 'Computational Needs for the Next Generation Electric Grid', was the culmination of a year-long process to bring together some of the Nation's leading researchers and experts to identify computational challenges associated with the operation and planning of the electric power system. The attached papers provide a journey into these experts' insights, highlighting a class of mathematical and computational problems relevant for potential power systems research. While each paper defines a specific problem area, there were several recurrent themes. First, the breadth and depth of power system data has expanded tremendously over the past decade. This provides the potential for new control approaches and operator tools that can enhance system efficiencies and improve reliability. However, the large volume of data poses its own challenges, and could benefit from application of advances in computer networking and architecture, as well as data base structures. Second, the computational complexity of the underlying system problems is growing. Transmitting electricity from clean, domestic energy resources in remote regions to urban consumers, for example, requires broader, regional planning over multi-decade time horizons. Yet, it may also mean operational focus on local solutions and shorter timescales, as reactive power and system dynamics (including fast switching and controls) play an increasingly critical role in achieving stability and ultimately reliability. The expected growth in reliance on variable renewable sources of electricity generation places an exclamation point on both of these observations, and highlights the need for new focus in areas such as stochastic optimization to accommodate the increased uncertainty that is occurring in both planning and operations. Application of research advances in algorithms (especially related to optimization techniques and uncertainty quantification) could accelerate power

  20. Advanced relay technologies in next generation wireless communications

    CERN Document Server

    Krikidis, Ioannis

    2016-01-01

    This book details the use of the cooperative networks/relaying approach in new and emerging telecommunications technologies such as full-duplex radio, massive multiple-input multiple-output (MIMO), network coding and spatial modulation, and new application areas including visible light communications (VLC), wireless power transfer, and 5G.

  1. Shaping the next generation of 'population oral healthers'.

    Science.gov (United States)

    Treasure, Elizabeth T

    2012-10-01

    The aim of this paper is to discuss the training and development needs of those people who will form the next generation working in the field of population oral health. The paper represents the personal views of the author based upon an analysis of current training programmes in a number of countries and variation in the international working conditions. The next generation of population oral healthers will need to be versatile in their approach to the oral health problems they encounter. The simple problems may well have been solved or have stopped improving. The future generation will work in a variety of roles: commissioning and designing services, providing and evaluating services, educating or researching. The working environment will also show considerable variation and diversity from entirely private systems through mixed economies to public systems and, of course, no system at all. Current curricula vary but tends to emphasis traditional epidemiological and statistical skills as well as service delivery. There is also some evidence that training opportunities are limited to those with clinical backgrounds. Universities continue to emphasis high quality, high impact and high financial value research as they seek to maximize income and climb international league tables. National research funding bodies are seeking to address major issues such as global warming, food security and international security. Health research appears to have a number of foci: increasingly complex biomedical research, economic and effectiveness research and the complex questions around diseases of poverty and lifestyle. Access to funding will be increasingly competitive. The next generation will need to access and understand an increasing range of disciplines using a wide range of transferable and political skills as they work across a diverse range of social situations and disease states. A key issue will be the requirement for them to be adaptable and flexible as they work to

  2. Feasibility of a next generation underground water Cherenkov detector: UNO

    International Nuclear Information System (INIS)

    Jung, Chang Kee

    2000-01-01

    The feasibility of a next generation underground water Cherenkov detector is examined and a conceptual design (UNO) is presented. The design has a linear detector configuration with a total volume of 650 kton which is 13 times the total volume of the Super-Kamiokande detector. It corresponds to a 20 times increase in fiducial volume for physics analysis. The physics goals of UNO are to increase the sensitivity of the search for nucleon decay by a factor of ten and to make precision measurements of the solar and atmospheric neutrino properties. In addition, the detection sensitivity for supernova neutrinos will reach as far as the Andromeda galaxy

  3. Technology Innovations from NASA's Next Generation Launch Technology Program

    Science.gov (United States)

    Cook, Stephen A.; Morris, Charles E. K., Jr.; Tyson, Richard W.

    2004-01-01

    NASA's Next Generation Launch Technology Program has been on the cutting edge of technology, improving the safety, affordability, and reliability of future space-launch-transportation systems. The array of projects focused on propulsion, airframe, and other vehicle systems. Achievements range from building miniature fuel/oxygen sensors to hot-firings of major rocket-engine systems as well as extreme thermo-mechanical testing of large-scale structures. Results to date have significantly advanced technology readiness for future space-launch systems using either airbreathing or rocket propulsion.

  4. A Healthcare-Delivery System for the Next Generation

    OpenAIRE

    2006-01-01

    On May 2-3, 2006, Purdue University, BlueCross BlueShield Association, and WellPoint, Inc. hosted 24 CEO-level healthcare executives representing a diverse cross section of the healthcare supply chain to design the U.S. healthcare-delivery system for the next generation. Participants were challenged to envision the ideal system for the future, without regard to the constraints of today’s technologies, infrastructure, or financial systems. The Regenstrief Center for Healthcare Engineering at P...

  5. Next Generation Space Telescope ultra-lightweight mirror program

    CERN Document Server

    Bilbro, J W

    1999-01-01

    The Next Generation Space Telescope is currently envisioned as an eight meter diameter cryogenic deployable telescope that will operate at the Earth sun libration point L2. A number of different designs are being examined within $9 NASA and under industry studies by Ball Aerospace, Lockheed-Martin and TRW. Although these designs differ in many respects, they all require significant advancements in the state-of-the-art with respect to large diameter, $9 ultra-lightweight, mirrors. The purpose of this paper is to provide insight into the current status of the mirror development program. (1 refs).

  6. Convergence of wireless, wireline, and photonics next generation networks

    CERN Document Server

    Iniewski, Krzysztof

    2010-01-01

    Filled with illustrations and practical examples from industry, this book provides a brief but comprehensive introduction to the next-generation wireless networks that will soon replace more traditional wired technologies. Written by a mixture of top industrial experts and key academic professors, it is the only book available that covers both wireless networks (such as wireless local area and personal area networks) and optical networks (such as long-haul and metropolitan networks) in one volume. It gives engineers and engineering students the necessary knowledge to meet challenges of next-ge

  7. Wireless next generation networks a virtue-based trust model

    CERN Document Server

    Harvey, Melissa

    2014-01-01

    This SpringerBrief proposes a trust model motivated by virtue epistemology, addressing the need for a more efficient and flexible trust model for wireless next generation networks. This theory of trust simplifies the computation and communication overhead of strictly cognitive-computational models of trust. Both the advantages and the challenges of virtue-based trust models are discussed. This brief offers new research and a general theory of rationality that enables users to interpret trust and reason as complementary mechanisms that guide our rational conduct at two different epistemic level

  8. The next generation of acetabular shell design and bearing surfaces.

    Science.gov (United States)

    Bourne, Robert B; McCalden, Richard W; Naudie, Douglas; Charron, Kory D J; Yuan, Xunhua; Holdsworth, David W

    2008-12-01

    The R3 Acetabular component represents the next generation of acetabular shell with an enhanced porous ingrowth surface (StikTite, Smith & Nephew, Memphis, Tenn) to meet the needs of both primary and revision hip arthroplasty; an optimized locking mechanism; and the ability to accomodate polyethylene, metal, or ceramic liners. This prospective clinical study reports on the safety and efficacy of the new StikTite porous ingrowth surface using radiostereometric analysis (RSA). StikTite provides a superior "sctratch-fit" due to its greater coefficient of friction and less micromotion using RSA measurements.

  9. A Survey on Next-generation Power Grid Data Architecture

    Energy Technology Data Exchange (ETDEWEB)

    You, Shutang [University of Tennessee, Knoxville (UTK); Zhu, Dr. Lin [University of Tennessee (UT); Liu, Yong [ORNL; Liu, Yilu [ORNL; Shankar, Mallikarjun (Arjun) [ORNL; Robertson, Russell [Grid Protection Alliance; King Jr, Thomas J [ORNL

    2015-01-01

    The operation and control of power grids will increasingly rely on data. A high-speed, reliable, flexible and secure data architecture is the prerequisite of the next-generation power grid. This paper summarizes the challenges in collecting and utilizing power grid data, and then provides reference data architecture for future power grids. Based on the data architecture deployment, related research on data architecture is reviewed and summarized in several categories including data measurement/actuation, data transmission, data service layer, data utilization, as well as two cross-cutting issues, interoperability and cyber security. Research gaps and future work are also presented.

  10. Next Generation Qualification: Kinemetrics STS-5A Seismometer Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Merchant, Bion John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Slad, George William [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-10-01

    Sandia National Laboratories has tested and evaluated two seismometers, the STS-5A, manufactured by Kinemetrics. These seismometers measure three axes of broadband ground velocity using a UVW configuration with feedback control in a mechanically levelled borehole package. The purpose of the seismometer evaluation was to determine a measured sensitivity, response, self-noise, dynamic range, and self-calibration ability. The Kinemetrics STS-5A seismometers are being evaluated for the U.S. Air Force as part of their Next Generation Qualification effort.

  11. Next Generation Nuclear Plant Materials Research and Development Program Plan

    Energy Technology Data Exchange (ETDEWEB)

    G. O. Hayner; E.L. Shaber

    2004-09-01

    The U.S Department of Energy (DOE) has selected the Very High Temperature Reactor (VHTR) design for the Next Generation Nuclear Plant (NGNP) Project. The NGNP will demonstrate the use of nuclear power for electricity and hydrogen production without greenhouse gas emissions. The reactor design will be a graphite moderated, helium-cooled, prismatic or pebble-bed, thermal neutron spectrum reactor that will produce electricity and hydrogen in a state-of-the-art thermodynamically efficient manner. The NGNP will use very high burn-up, low-enriched uranium, TRISO-coated fuel and have a projected plant design service life of 60 years.

  12. Next Generation Nuclear Plant Materials Selection and Qualification Program Plan

    Energy Technology Data Exchange (ETDEWEB)

    R. Doug Hamelin; G. O. Hayner

    2004-11-01

    The U.S. Department of Energy (DOE) has selected the Very High Temperature Reactor (VHTR) design for the Next Generation Nuclear Plant (NGNP) Project. The NGNP will demonstrate the use of nuclear power for electricity and hydrogen production without greenhouse gas emissions. The reactor design is a graphite-moderated, helium-cooled, prismatic or pebble bed thermal neutron spectrum reactor with an average reactor outlet temperature of at least 1000 C. The NGNP will use very high burn up, lowenriched uranium, TRISO-Coated fuel in a once-through fuel cycle. The design service life of the NGNP is 60 years.

  13. Use of next-generation sequencing in oral cavity cancer

    DEFF Research Database (Denmark)

    Tabatabaeifar, Siavosh; Kruse, Torben A; Thomassen, Mads

    of tumour cells exists. Conclusions: Use of next generation sequencing in oral cavity cancer can give valuable insight into the biology of the disease. By investigating intra tumour heterogeneity we see that the different tumour specimens in each patient are quite homogenous, but evidence of heterogeneous......Background: Oral cavity cancer is a subgroup of head and neck cancer which is the world’s 6th most common cancer form. Oral squamous cell carcinomas (OSCC) constitute almost all oral cavity cancers, and OSCC are primarily attributed by excessive alcohol consumption and tobacco exposure...

  14. Analysis of next-generation sequencing data using Galaxy.

    Science.gov (United States)

    Blankenberg, Daniel; Hillman-Jackson, Jennifer

    2014-01-01

    The extraordinary throughput of next-generation sequencing (NGS) technology is outpacing our ability to analyze and interpret the data. This chapter will focus on practical informatics methods, strategies, and software tools for transforming NGS data into usable information through the use of a web-based platform, Galaxy. The Galaxy interface is explored through several different types of example analyses. Instructions for running one's own Galaxy server on local hardware or on cloud computing resources are provided. Installing new tools into a personal Galaxy instance is also demonstrated.

  15. The Role of Semantics in Next-Generation Online Virtual World-Based Retail Store

    Science.gov (United States)

    Sharma, Geetika; Anantaram, C.; Ghosh, Hiranmay

    Online virtual environments are increasingly becoming popular for entrepreneurship. While interactions are primarily between avatars, some interactions could occur through intelligent chatbots. Such interactions require connecting to backend business applications to obtain information, carry out real-world transactions etc. In this paper, we focus on integrating business application systems with virtual worlds. We discuss the probable features of a next-generation online virtual world-based retail store and the technologies involved in realizing the features of such a store. In particular, we examine the role of semantics in integrating popular virtual worlds with business applications to provide natural language based interactions.

  16. Next-generation sequencing (NGS for assessment of microbial water quality: current progress, challenges, and future opportunities

    Directory of Open Access Journals (Sweden)

    BoonFei eTan

    2015-09-01

    Full Text Available Water quality is an emergent property of a complex system comprised of interacting microbial populations and introduced microbial and chemical contaminants. Studies leveraging next-generation sequencing (NGS technologies are providing new insights into the ecology of microbially mediated processes that influence fresh water quality such as algal blooms, contaminant biodegradation, and pathogen dissemination. In addition, sequencing methods targeting small subunit (SSU rRNA hypervariable regions have allowed identification of signature microbial species that serve as bioindicators for sewage contamination in these environments. Beyond amplicon sequencing, metagenomic and metatranscriptomic analyses of microbial communities in fresh water environments reveal the genetic capabilities and interplay of waterborne microorganisms, shedding light on the mechanisms for production and biodegradation of toxins and other contaminants. This review discusses the challenges and benefits of applying NGS-based methods to water quality research and assessment. We will consider the suitability and biases inherent in the application of NGS as a screening tool for assessment of biological risks and discuss the potential and limitations for direct quantitative interpretation of NGS data. Secondly, we will examine case studies from recent literature where NGS based methods have been applied to topics in water quality assessment, including development of bioindicators for sewage pollution and microbial source tracking, characterizing the distribution of toxin and antibiotic resistance genes in water samples, and investigating mechanisms of biodegradation of harmful pollutants that threaten water quality. Finally, we provide a short review of emerging NGS platforms and their potential applications to the next generation of water quality assessment tools.

  17. Advanced Ceramic Materials For Next-Generation Nuclear Applications

    International Nuclear Information System (INIS)

    Marra, J.

    2010-01-01

    Rising global energy demands coupled with increased environmental concerns point to one solution; they must reduce their dependence on fossil fuels that emit greenhouse gases. As the global community faces the challenge of maintaining sovereign nation security, reducing greenhouse gases, and addressing climate change nuclear power will play a significant and likely growing role. In the US, nuclear energy already provides approximately one-fifth of the electricity used to power factories, offices, homes, and schools with 104 operating nuclear power plants, located at 65 sites in 31 states. Additionally, 19 utilities have applied to the US Nuclear Regulatory Commission (NRC) for construction and operating licenses for 26 new reactors at 17 sites. This planned growth of nuclear power is occurring worldwide and has been termed the 'nuclear renaissance.' As major industrial nations craft their energy future, there are several important factors that must be considered about nuclear energy: (1) it has been proven over the last 40 years to be safe, reliable and affordable (good for Economic Security); (2) its technology and fuel can be domestically produced or obtained from allied nations (good for Energy Security); and (3) it is nearly free of greenhouse gas emissions (good for Environmental Security). Already an important part of worldwide energy security via electricity generation, nuclear energy can also potentially play an important role in industrial processes and supporting the nation's transportation sector. Coal-to-liquid processes, the generation of hydrogen and supporting the growing potential for a greatly increased electric transportation system (i.e. cars and trains) mean that nuclear energy could see dramatic growth in the near future as we seek to meet our growing demand for energy in cleaner, more secure ways. In order to address some of the prominent issues associated with nuclear power generation (i.e., high capital costs, waste management, and proliferation), the worldwide community is working to develop and deploy new nuclear energy systems and advanced fuel cycles. These new nuclear systems address the key challenges and include: (1) extracting the full energy value of the nuclear fuel; (2) creating waste solutions with improved long term safety; (3) minimizing the potential for the misuse of the technology and materials for weapons; (4) continually improving the safety of nuclear energy systems; and (5) keeping the cost of energy affordable.

  18. Applications of next generation sequencing in (epi)genetics

    NARCIS (Netherlands)

    Mokry, M.

    2011-01-01

    Technological developments in DNA sequencing are an excellent example of how major advances in scientific techniques can lead to numerous conceptual discoveries in the life sciences. Starting in the 1970s with the development of DNA sequencing by chain termination methods, through the introduction

  19. Standard Analyzer of VHDL Applications for Next Generation Technology (SAVANT)

    National Research Council Canada - National Science Library

    Hirsch, Herbert

    1995-01-01

    ... (IF) for the exchange of VHDL encoded electronic data among CAD systems. This absence has severely constrained basic research environments, and has precipitated the current sub-optimal nature of CAD in VHDL tool development...

  20. Enabling Next-Generation Multicore Platforms in Embedded Applications

    Science.gov (United States)

    2014-04-01

    or a preemptive resource. This gives rise to four different classes of allocation policies, depending upon whether the processor or the cache is...transitive closure of direct contention, D. We define each equivalence class in D+ to be a logical cache processor. By definition, all tasks on the same...J.V.B. Mataix. Static use of locking caches in multitask preemptive real-time systems. In Proceedings of the IEEE Real-Time Embedded Systems

  1. Next generation sequencing (NGS)technologies and applications

    Energy Technology Data Exchange (ETDEWEB)

    Vuyisich, Momchilo [Los Alamos National Laboratory

    2012-09-11

    NGS technology overview: (1) NGS library preparation - Nucleic acids extraction, Sample quality control, RNA conversion to cDNA, Addition of sequencing adapters, Quality control of library; (2) Sequencing - Clonal amplification of library fragments, (except PacBio), Sequencing by synthesis, Data output (reads and quality); and (3) Data analysis - Read mapping, Genome assembly, Gene expression, Operon structure, sRNA discovery, and Epigenetic analyses.

  2. Next generation sequencing and its applications in forensic genetics

    DEFF Research Database (Denmark)

    Børsting, Claus; Morling, Niels

    2015-01-01

    matured during the last 10 years, and the quality of the sequences has reached a level where NGS is used in clinical diagnostics of humans. Forensic genetic laboratories have also explored NGS technologies and especially in the last year, there has been a small explosion in the number of scientific...... articles and presentations at conferences with forensic aspects of NGS. These contributions have demonstrated that NGS offers new possibilities for forensic genetic case work. More information may be obtained from unique samples in a single experiment by analyzing combinations of markers (STRs, SNPs......, insertion/deletions, mRNA) that cannot be analyzed simultaneously with the standard PCR-CE methods used today. The true variation in core forensic STR loci has been uncovered, and previously unknown STR alleles have been discovered. The detailed sequence information may aid mixture interpretation...

  3. Next generation sequencing and comparative analyses of Xenopus mitogenomes

    Directory of Open Access Journals (Sweden)

    Lloyd Rhiannon E

    2012-09-01

    -coding genes were shown to be under strong negative (purifying selection, with genes under the strongest pressure (Complex 4 also being the most highly expressed, highlighting their potentially crucial functions in the mitochondrial respiratory chain. Conclusions Next generation sequencing of long-PCR amplicons using single taxon or multi-taxon approaches enabled two new species of Xenopus mtDNA to be fully characterized. We anticipate our complete mitochondrial genome amplification methods to be applicable to other amphibians, helpful for identifying the most appropriate markers for differentiating species, populations and resolving phylogenies, a pressing need since amphibians are undergoing drastic global decline. Our mtDNAs also provide templates for conserved primer design and the assembly of RNA and DNA reads following high throughput “omic” techniques such as RNA- and ChIP-seq. These could help us better understand how processes such mitochondrial replication and gene expression influence xenopus growth and development, as well as how they evolved and are regulated.

  4. Software Defined Radio Architecture Contributions to Next Generation Space Communications

    Science.gov (United States)

    Kacpura, Thomas J.; Eddy, Wesley M.; Smith, Carl R.; Liebetreu, John

    2015-01-01

    systems, as well as those communications and navigation systems operated by international space agencies and civilian and government agencies. In this paper, we review the philosophies, technologies, architectural attributes, mission services, and communications capabilities that form the structure of candidate next-generation integrated communication architectures for space communications and navigation. A key area that this paper explores is from the development and operation of the software defined radio for the NASA Space Communications and Navigation (SCaN) Testbed currently on the International Space Station (ISS). Evaluating the lessons learned from development and operation feed back into the communications architecture. Leveraging the reconfigurability provides a change in the way that operations are done and must be considered. Quantifying the impact on the NASA Space Telecommunications Radio System (STRS) software defined radio architecture provides feedback to keep the standard useful and up to date. NASA is not the only customer of these radios. Software defined radios are developed for other applications, and taking advantage of these developments promotes an architecture that is cost effective and sustainable. Developments in the following areas such as an updated operating environment, higher data rates, networking and security can be leveraged. The ability to sustain an architecture that uses radios for multiple markets can lower costs and keep new technology infused.

  5. Shaping laser accelerated ions for future applications – The LIGHT collaboration

    Energy Technology Data Exchange (ETDEWEB)

    Busold, S., E-mail: s.busold@gsi.de [Institut für Kernphysik, Technische Universität Darmstadt, Schloßgartenstraße 9, D-64289 Darmstadt (Germany); Almomani, A. [Institut für angewandte Physik, Johann-Wolfgang-Goethe-Universität Frankfurt, Max von Laue Straße 1, D-60438 Frankfurt (Germany); Bagnoud, V. [GSI Helmholtzzentrum für Schwerionenforschung, Planckstraße 1, D-64291 Darmstadt (Germany); Helmholtz Institut Jena, Fröbelstieg 3, D-07734 Jena (Germany); Barth, W. [GSI Helmholtzzentrum für Schwerionenforschung, Planckstraße 1, D-64291 Darmstadt (Germany); Bedacht, S. [Institut für Kernphysik, Technische Universität Darmstadt, Schloßgartenstraße 9, D-64289 Darmstadt (Germany); Blažević, A. [GSI Helmholtzzentrum für Schwerionenforschung, Planckstraße 1, D-64291 Darmstadt (Germany); Helmholtz Institut Jena, Fröbelstieg 3, D-07734 Jena (Germany); Boine-Frankenheim, O. [GSI Helmholtzzentrum für Schwerionenforschung, Planckstraße 1, D-64291 Darmstadt (Germany); Institut für Theorie Elektromagnetischer Felder, Technische Universität Darmstadt, Schloßgartenstraße 8, D-64289 Darmstadt (Germany); and others

    2014-03-11

    The generation of intense ion beams from high-intensity laser-generated plasmas has been the focus of research for the last decade. In the LIGHT collaboration the expertise of heavy ion accelerator scientists and laser and plasma physicists has been combined to investigate the prospect of merging these ion beams with conventional accelerator technology and exploring the possibilities of future applications. We report about the goals and first results of the LIGHT collaboration to generate, handle and transport laser driven ion beams. This effort constitutes an important step in research for next generation accelerator technologies.

  6. 25 years of endothelin research: the next generation.

    Science.gov (United States)

    Emoto, Noriaki; Vignon-Zellweger, Nicolas; Lopes, Rhéure Alves Moreira; Cacioppo, Joseph; Desbiens, Louisane; Kamato, Danielle; Leurgans, Thomas; Moorhouse, Rebecca; Straube, Julia; Wurm, Raphael; Heiden, Susi; Ergul, Adviye; Yanagisawa, Masashi; Barton, Matthias

    2014-11-24

    In the past three decades, endothelin and endothelin receptor antagonists have received great scientific and clinical interest, leading to the publication of more than 27,000 scientific articles since its discovery. The Thirteenth International Conference on Endothelin (ET-13) was held on September 8-11, 2013, at Tokyo Campus of the University of Tsukuba in Japan. Close to 300 scientists from 25 countries from around the world came to Tokyo to celebrate the anniversary of the discovery of the endothelin peptide discovered 25 years ago at the University of Tsukuba. This article summarizes some of the highlights of the conference, the anniversary celebration ceremony, and particularly the participation of next generation of endothelin researchers in endothelin science and the anniversary celebration. As a particular highlight, next generation endothelin researchers wrote a haiku (a traditional form of Japanese poetry originating from consisting of no more than three short verses and 27 on, or Japanese phonetic units) to describe the magic of endothelin science which they presented to the conference audience at the anniversary ceremony. The text of each haiku - both in its original language together with the English translation - is part of this article providing in an exemplary fashion how poetry can be bridged with science. Finally, we give an outlook towards the next 25 years of endothelin research. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

    Directory of Open Access Journals (Sweden)

    Patrice D. Cani

    2017-09-01

    Full Text Available Metabolic disorders associated with obesity and cardiometabolic disorders are worldwide epidemic. Among the different environmental factors, the gut microbiota is now considered as a key player interfering with energy metabolism and host susceptibility to several non-communicable diseases. Among the next-generation beneficial microbes that have been identified, Akkermansia muciniphila is a promising candidate. Indeed, A. muciniphila is inversely associated with obesity, diabetes, cardiometabolic diseases and low-grade inflammation. Besides the numerous correlations observed, a large body of evidence has demonstrated the causal beneficial impact of this bacterium in a variety of preclinical models. Translating these exciting observations to human would be the next logic step and it now appears that several obstacles that would prevent the use of A. muciniphila administration in humans have been overcome. Moreover, several lines of evidence indicate that pasteurization of A. muciniphila not only increases its stability but more importantly increases its efficacy. This strongly positions A. muciniphila in the forefront of next-generation candidates for developing novel food or pharma supplements with beneficial effects. Finally, a specific protein present on the outer membrane of A. muciniphila, termed Amuc_1100, could be strong candidate for future drug development. In conclusion, as plants and its related knowledge, known as pharmacognosy, have been the source for designing drugs over the last century, we propose that microbes and microbiomegnosy, or knowledge of our gut microbiome, can become a novel source of future therapies.

  8. Next Generation Workload Management and Analysis System for Big Data

    Energy Technology Data Exchange (ETDEWEB)

    De, Kaushik [Univ. of Texas, Arlington, TX (United States)

    2017-04-24

    We report on the activities and accomplishments of a four-year project (a three-year grant followed by a one-year no cost extension) to develop a next generation workload management system for Big Data. The new system is based on the highly successful PanDA software developed for High Energy Physics (HEP) in 2005. PanDA is used by the ATLAS experiment at the Large Hadron Collider (LHC), and the AMS experiment at the space station. The program of work described here was carried out by two teams of developers working collaboratively at Brookhaven National Laboratory (BNL) and the University of Texas at Arlington (UTA). These teams worked closely with the original PanDA team – for the sake of clarity the work of the next generation team will be referred to as the BigPanDA project. Their work has led to the adoption of BigPanDA by the COMPASS experiment at CERN, and many other experiments and science projects worldwide.

  9. Biomimetic Artificial Basilar Membranes for Next-Generation Cochlear Implants.

    Science.gov (United States)

    Jang, Jongmoon; Jang, Jeong Hun; Choi, Hongsoo

    2017-11-01

    Patients with sensorineural hearing loss can recover their hearing using a cochlear implant (CI). However, there is a need to develop next-generation CIs to overcome the limitations of conventional CIs caused by extracorporeal devices. Recently, artificial basilar membranes (ABMs) are actively studied for next-generation CIs. The ABM is an acoustic transducer that mimics the mechanical frequency selectivity of the BM and acoustic-to-electrical energy conversion of hair cells. This paper presents recent progress in biomimetic ABMs. First, the characteristics of frequency selectivity of the ABMs by the trapezoidal membrane and beam array are addressed. Second, to reflect the latest research of energy conversion technologies, ABMs using various piezoelectric materials and triboelectric-based ABMs are discussed. Third, in vivo evaluations of the ABMs in animal models are discussed according to the target position for implantation. Finally, future perspectives of ABM studies for the development of practical hearing devices are discussed. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Update on next generation metrology tool for DPL reticles

    Science.gov (United States)

    Roeth, Klaus-Dieter; Bender, Jochen; Laske, Frank; Adam, Dieter; Schmidt, Karl-Heinrich

    2010-05-01

    Double Patterning Lithography (DPL) techniques for next generation wafer exposures are placing greater demand on the requirements for pattern placement accuracy on photomasks for three reasons. First, a new source of wafer overlay error results from interactions between the two masks, so the specification for each individual mask must be tightened to compensate. Second, specifications have become so tight that the distortion caused by the pellicle bending the mask has become a significant contributor to the wafer overlay error budget. Pellicle-induced distortions are particularly insidious because they are not repeatable from substrate to substrate. Third, the tightening of overlay specifications demands tighter e-beam pattern placement control throughout the die, regardless of pattern density. This makes measuring actual features in-die instead of registration test structures important. The combination of increased demand for greater pattern placement accuracy, a need to characterize the influence of pellicle distortions, and the requirement to measure actual device features drives the need for a pattern placement metrology system capable of high resolution through-pellicle in-die measurements. Key enablers of this capability include high measurement resolution, a low noise platform and a long working distance objective. This paper reports experimental results on mask features of various sizes using a next-generation pattern placement metrology system designed to meet the strict DPL requirements outlined here.

  11. Engineering Micromechanical Systems for the Next Generation Wireless Capsule Endoscopy.

    Science.gov (United States)

    Woods, Stephen; Constandinou, Timothy

    2015-01-01

    Wireless capsule endoscopy (WCE) enables the detection and diagnosis of inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. However treatment of these pathologies can only be achieved through conventional means. This paper describes the next generation WCE with increased functionality to enable targeted drug delivery in the small intestinal tract. A prototype microrobot fabricated in Nylon 6 is presented which is capable of resisting peristaltic pressure through the deployment of an integrated holding mechanism and delivering targeted therapy. The holding action is achieved by extending an "anchor" spanning a 60.4 mm circumference, for an 11.0 mm diameter WCE. This function is achieved by a mechanism that occupies only 347.0 mm(3) volume, including mechanics and actuator. A micropositioning mechanism is described which utilises a single micromotor to radially position and then deploy a needle 1.5 mm outside the microrobot's body to deliver a 1 mL dose of medication to a targeted site. An analysis of the mechanics required to drive the holding mechanism is presented and an overview of microactuators and the state of the art in WCE is discussed. It is envisaged that this novel functionality will empower the next generation of WCE to help diagnose and treat pathologies of the GI tract.

  12. Standardization and quality management in next-generation sequencing.

    Science.gov (United States)

    Endrullat, Christoph; Glökler, Jörn; Franke, Philipp; Frohme, Marcus

    2016-09-01

    DNA sequencing continues to evolve quickly even after > 30 years. Many new platforms suddenly appeared and former established systems have vanished in almost the same manner. Since establishment of next-generation sequencing devices, this progress gains momentum due to the continually growing demand for higher throughput, lower costs and better quality of data. In consequence of this rapid development, standardized procedures and data formats as well as comprehensive quality management considerations are still scarce. Here, we listed and summarized current standardization efforts and quality management initiatives from companies, organizations and societies in form of published studies and ongoing projects. These comprise on the one hand quality documentation issues like technical notes, accreditation checklists and guidelines for validation of sequencing workflows. On the other hand, general standard proposals and quality metrics are developed and applied to the sequencing workflow steps with the main focus on upstream processes. Finally, certain standard developments for downstream pipeline data handling, processing and storage are discussed in brief. These standardization approaches represent a first basis for continuing work in order to prospectively implement next-generation sequencing in important areas such as clinical diagnostics, where reliable results and fast processing is crucial. Additionally, these efforts will exert a decisive influence on traceability and reproducibility of sequence data.

  13. Engineering Micromechanical Systems for the Next Generation Wireless Capsule Endoscopy

    Directory of Open Access Journals (Sweden)

    Stephen Woods

    2015-01-01

    Full Text Available Wireless capsule endoscopy (WCE enables the detection and diagnosis of inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis. However treatment of these pathologies can only be achieved through conventional means. This paper describes the next generation WCE with increased functionality to enable targeted drug delivery in the small intestinal tract. A prototype microrobot fabricated in Nylon 6 is presented which is capable of resisting peristaltic pressure through the deployment of an integrated holding mechanism and delivering targeted therapy. The holding action is achieved by extending an “anchor” spanning a 60.4 mm circumference, for an 11.0 mm diameter WCE. This function is achieved by a mechanism that occupies only 347.0 mm3 volume, including mechanics and actuator. A micropositioning mechanism is described which utilises a single micromotor to radially position and then deploy a needle 1.5 mm outside the microrobot’s body to deliver a 1 mL dose of medication to a targeted site. An analysis of the mechanics required to drive the holding mechanism is presented and an overview of microactuators and the state of the art in WCE is discussed. It is envisaged that this novel functionality will empower the next generation of WCE to help diagnose and treat pathologies of the GI tract.

  14. Estabilishing requirements for the next generation of pressurized water reactors--reducing the uncertainty

    International Nuclear Information System (INIS)

    Chernock, W.P.; Corcoran, W.R.; Rasin, W.H.; Stahlkopf, K.E.

    1987-01-01

    The Electric Power Research Institute is managing a major effort to establish requirements for the next generation of U.S. light water reactors. This effort is the vital first step in preserving the viability of the nuclear option to contribute to meet U.S. national electric power capacity needs in the next century. Combustion Engineering, Inc. and Duke Power Company formed a team to participate in the EPRI program which is guided by a Utility Steering committee consisting of experienced utility technical executives. A major thrust of the program is to reduce the uncertainties which would be faced by the utility executives in choosing the nuclear option. The uncertainties to be reduced include those related to safety, economic, operational, and regulatory aspects of advanced light water reactors. This paper overviews the Requirements Document program as it relates to the U.S. Advanced Light Water Reactor (ALWR) effort in reducing these uncertainties and reports the status of efforts to establish requirements for the next generation of pressurized water reactors. It concentrates on progress made in reducing the uncertainties which would deter selection of the nuclear option for contributing to U.S. national electric power capacity needs in the next century and updates previous reports in the same area. (author)

  15. Next Generation Nuclear Plant Project 2009 Status Report

    Energy Technology Data Exchange (ETDEWEB)

    Larry Demick; Jim Kinsey; Keith Perry; Dave Petti

    2010-05-01

    The mission of the NGNP Project is to broaden the environmental and economic benefits of nuclear energy technology to the United States and other economies by demonstrating its applicability to market sectors not served by light water reactors (LWRs). Those markets typically use fossil fuels to fulfill their energy needs, and high temperature gas-cooled reactors (HTGRs) like the NGNP can reduce this dependence and the resulting carbon footprint.

  16. Compact 2100 nm laser diode module for next-generation DIRCM

    Science.gov (United States)

    Dvinelis, Edgaras; Greibus, Mindaugas; TrinkÅ«nas, Augustinas; NaujokaitÄ--, Greta; Vizbaras, Augustinas; Vizbaras, Dominykas; Vizbaras, Kristijonas

    2017-10-01

    Compact high-power 2100 nm laser diode module for next-generation directional infrared countermeasure (DIRCM) systems is presented. Next-generation DIRCM systems require compact, light-weight and robust laser modules which could provide intense IR light emission capable of disrupting the tracking sensor of heat-seeking missile. Currently used solid-state and fiber laser solutions for mid-IR band are bulky and heavy making them difficult to implement in smaller form-factor DIRCM systems. Recent development of GaSb laser diode technology greatly improved optical output powers and efficiencies of laser diodes working in 1900 - 2450 nm band [1] while also maintaining very attractive size, weight, power consumption and cost characteristics. 2100 nm laser diode module presented in this work performance is based on high-efficiency broad emitting area GaSb laser diode technology. Each laser diode emitter is able to provide 1 W of CW output optical power with working point efficiency up to 20% at temperature of 20 °C. For output beam collimation custom designed fast-axis collimator and slow-axis collimator lenses were used. These lenses were actively aligned and attached using UV epoxy curing. Total 2 emitters stacked vertically were used in 2100 nm laser diode module. Final optical output power of the module goes up to 2 W at temperature of 20 °C. Total dimensions of the laser diode module are 35 x 25 x 16 mm (L x W x H) with a weight of 28 grams. Finally output beam is bore-sighted to mechanical axes of the module housing allowing for easy integration into next-generation DIRCM systems.

  17. Is there anything left for the next generation of leaders?

    Science.gov (United States)

    Volpe, Anthony

    2004-01-01

    Dean Arthur A. Dugoni is celebrated as the "dean of deans" or American dental schools. His service as a practitioner, rich network of relationships, recognition of emerging opportunities, respectful treatment of all, and ability to make people care and promote loyalty are identified. Significant issues remain for future leadership to address: dental caries is on the rebound, insurance is inadequate to provide needed coverage, prevention must be strengthened, education struggles with too few teachers and high tuition, the mobility of dentists is unrealistically restricted, and the pool of retired dentists who want to donate their services is hobbled by regulations. The ADA can take the leadership in some of these areas, but there is much left to be done by the next generation of individual leaders in the mold of Dean Dugoni.

  18. Final Report for "Analyzing and visualizing next generation climate data"

    Energy Technology Data Exchange (ETDEWEB)

    Pletzer, Alexander

    2012-11-13

    The project "Analyzing and visualizing next generation climate data" adds block-structured (mosaic) grid support, parallel processing, and 2D/3D curvilinear interpolation to the open-source UV-CDAT climate data analysis tool. Block structured grid support complies to the Gridspec extension submitted to the Climate and Forecast metadata conventions. It contains two parts: aggregation of data spread over multiple mosaic tiles (M-SPEC) and aggregation of temporal data stored in different files (F-SPEC). Together, M-SPEC and F-SPEC allow users to interact with data stored in multiple files as if the data were in a single file. For computational expensive tasks, a flexible, multi-dimensional, multi-type distributed array class allows users to process data in parallel using remote memory access. Both nodal and cell based interpolation is supported; users can choose between different interpolation libraries including ESMF and LibCF depending on the their particular needs.

  19. Prioritizing Signaling Information Transmission in Next Generation Networks

    Directory of Open Access Journals (Sweden)

    Jasmina Baraković

    2011-01-01

    Full Text Available Next generation transport network is characterized by the use of in-band signaling, where Internet Protocol (IP packets carrying signaling or media information are mixed in transmission. Since transport resources are limited, when any segment of access or core network is congested, IP packets carrying signaling information may be discarded. As a consequence, it may be impossible to implement reachability and quality of service (QoS. Since present approaches are insufficient to completely address this problem, a novel approach is proposed, which is based on prioritizing signaling information transmission. To proof the concept, a simulation study was performed using Network Simulator version 2 (ns-2 and independently developed Session Initiation Protocol (SIP module. The obtained results were statistically processed using Statistical Package for the Social Sciences (SPSS version 15.0. Summarizing our research results, several issues are identified for future work.

  20. Next Generation GPS Ground Control Segment (OCX) Navigation Design

    Science.gov (United States)

    Bertiger, Willy; Bar-Sever, Yoaz; Harvey, Nate; Miller, Kevin; Romans, Larry; Weiss, Jan; Doyle, Larry; Solorzano, Tara; Petzinger, John; Stell, Al

    2010-01-01

    In February 2010, a Raytheon-led team was selected by The Air Force to develop, implement, and operate the next generation GPS ground control segment (OCX). To meet and exceed the demanding OCX navigation performance requirements, the Raytheon team partnered with ITT (Navigation lead) and JPL to adapt major elements of JPL's navigation technology, proven in the operations of the Global Differential GPS (GDGPS) System. Key design goals for the navigation subsystem include accurate ephemeris and clock accuracy (user range error), ease of model upgrades, and a smooth and safe transition from the legacy system to OCX.We will describe key elements of the innovative architecture of the OCX navigation subsystem,and demonstrate the anticipated performance of the system through high fidelity simulations withactual GPS measurements.

  1. Rapid Conditioning for the Next Generation Melting System

    Energy Technology Data Exchange (ETDEWEB)

    Rue, David M. [Gas Technology Institute, Des Plaines, IL (United States)

    2015-06-17

    This report describes work on Rapid Conditioning for the Next Generation Melting System under US Department of Energy Contract DE-FC36-06GO16010. The project lead was the Gas Technology Institute (GTI). Partners included Owens Corning and Johns Manville. Cost share for this project was provided by NYSERDA (the New York State Energy Research and Development Authority), Owens Corning, Johns Manville, Owens Illinois, and the US natural gas industry through GTI’s SMP and UTD programs. The overreaching focus of this project was to study and develop rapid refining approaches for segmented glass manufacturing processes using high-intensity melters such as the submerged combustion melter. The objectives of this project were to 1) test and evaluate the most promising approaches to rapidly condition the homogeneous glass produced from the submerged combustion melter, and 2) to design a pilot-scale NGMS system for fiberglass recycle.

  2. Engineering microbes for tolerance to next-generation biofuels

    Directory of Open Access Journals (Sweden)

    Dunlop Mary J

    2011-09-01

    Full Text Available Abstract A major challenge when using microorganisms to produce bulk chemicals such as biofuels is that the production targets are often toxic to cells. Many biofuels are known to reduce cell viability through damage to the cell membrane and interference with essential physiological processes. Therefore, cells must trade off biofuel production and survival, reducing potential yields. Recently, there have been several efforts towards engineering strains for biofuel tolerance. Promising methods include engineering biofuel export systems, heat shock proteins, membrane modifications, more general stress responses, and approaches that integrate multiple tolerance strategies. In addition, in situ recovery methods and media supplements can help to ease the burden of end-product toxicity and may be used in combination with genetic approaches. Recent advances in systems and synthetic biology provide a framework for tolerance engineering. This review highlights recent targeted approaches towards improving microbial tolerance to next-generation biofuels with a particular emphasis on strategies that will improve production.

  3. Understanding Cancer Genome and Its Evolution by Next Generation Sequencing

    DEFF Research Database (Denmark)

    Hou, Yong

    knowledge we previously know. There is very limited knowledge of East Asia lung cancer genome except enrichment of EGFR mutations and lack of KRAS mutations. We carried out integrated genomic, transcriptomic and methylomic analysis of 335 primary Chinese lung adenocarcinomas (LUAD) and 35 corresponding......Cancer will cause 13 million deaths by the year of 2030, ranking the second leading cause of death worldwide. Previous studies indicate that most of the cancers originate from cells that acquired somatic mutations and evolved as Darwin Theory. Ten biological insights of cancer have been summarized...... recently. Cutting-age technologies like next generation sequencing (NGS) enable exploring cancer genome and evolution much more efficiently. However, integrated cancer genome sequencing studies showed great inter-/intra-tumoral heterogeneity (ITH) and complex evolution patterns beyond the cancer biological...

  4. High stability laser for next generation gravity missions

    Science.gov (United States)

    Nicklaus, K.; Herding, M.; Wang, X.; Beller, N.; Fitzau, O.; Giesberts, M.; Herper, M.; Barwood, G. P.; Williams, R. A.; Gill, P.; Koegel, H.; Webster, S. A.; Gohlke, M.

    2017-11-01

    With GRACE (launched 2002) and GOCE (launched 2009) two very successful missions to measure earth's gravity field have been in orbit, both leading to a large number of publications. For a potential Next Generation Gravity Mission (NGGM) from ESA a satellite-to-satellite tracking (SST) scheme, similar to GRACE is under discussion, with a laser ranging interferometer instead of a Ka-Band link to enable much lower measurement noise. Of key importance for such a laser interferometer is a single frequency laser source with a linewidth collaboration the JPL contributions are the instrument electronics, the reference cavity and the single frequency laser, while STI as the German industry prime is responsible for the optical bench and the retroreflector. In preparation of NGGM an all European instrument development is the goal.

  5. Efficient Video Streaming Scheme for Next Generations of Mobile Networks

    Directory of Open Access Journals (Sweden)

    Majdi Ashibani

    2005-04-01

    Full Text Available Video streaming over next generations of mobile networks has undergone enormous development recently due to the continuing growth in wireless communication, especially since the emergence of 3G wireless networks. The new generations of wireless networks pose many challenges, including supporting quality of service over wireless communication links. This is due to the time-varying characteristics of wireless channel. Therefore, a more flexible and efficient bandwidth allocation scheme is needed. This paper is a part of ongoing work to come up with a more robust scheme that is capable of rapidly adapting to changes in network conditions. The proposed scheme focuses on the wireless part of the network, providing high quality video service and better utilization of network resources.

  6. Potential of OFDM for next generation optical access

    Science.gov (United States)

    Fritzsche, Daniel; Weis, Erik; Breuer, Dirk

    2011-01-01

    This paper shows the requirements for next generation optical access (NGOA) networks and analyzes the potential of OFDM (orthogonal frequency division multiplexing) for the use in such network scenarios. First, we show the motivation for NGOA systems based on the future requirements on FTTH access systems and list the advantages of OFDM in such scenarios. In the next part, the basics of OFDM and different methods to generate and detect optical OFDM signals are explained and analyzed. At the transmitter side the options include intensity modulation and the more advanced field modulation of the optical OFDM signal. At the receiver there is the choice between direct detection and coherent detection. As the result of this discussion we show our vision of the future use of OFDM in optical access networks.

  7. Next Generation Agricultural System Data, Models and Knowledge Products: Introduction

    Science.gov (United States)

    Antle, John M.; Jones, James W.; Rosenzweig, Cynthia E.

    2016-01-01

    Agricultural system models have become important tools to provide predictive and assessment capability to a growing array of decision-makers in the private and public sectors. Despite ongoing research and model improvements, many of the agricultural models today are direct descendants of research investments initially made 30-40 years ago, and many of the major advances in data, information and communication technology (ICT) of the past decade have not been fully exploited. The purpose of this Special Issue of Agricultural Systems is to lay the foundation for the next generation of agricultural systems data, models and knowledge products. The Special Issue is based on a 'NextGen' study led by the Agricultural Model Intercomparison and Improvement Project (AgMIP) with support from the Bill and Melinda Gates Foundation.

  8. The Next Generation Transit Survey—Prototyping Phase

    Science.gov (United States)

    McCormac, J.; Pollacco, D.; Wheatley, P. J.; West, R. G.; Walker, S.; Bento, J.; Skillen, I.; Faedi, F.; Burleigh, M. R.; Casewell, S. L.; Chazelas, B.; Genolet, L.; Gibson, N. P.; Goad, M. R.; Lawrie, K. A.; Ryans, R.; Todd, I.; Udry, S.; Watson, C. A.

    2017-02-01

    We present the prototype telescope for the Next Generation Transit Survey, which was built in the UK in 2008/2009 and tested on La Palma in the Canary Islands in 2010. The goals for the prototype system were severalfold: to determine the level of systematic noise in an NGTS-like system; demonstrate that we can perform photometry at the (sub) millimagnitude level on transit timescales across a wide-field; show that it is possible to detect transiting super-Earth and Neptune-sized exoplanets and prove the technical feasibility of the proposed planet survey. We tested the system for around 100 nights and met each of the goals above. Several key areas for improvement were highlighted during the prototyping phase. They have been subsequently addressed in the final NGTS facility, which was recently commissioned at ESO Cerro Paranal, Chile.

  9. Beam generation at next generation RIB facilities: conceptual design studies

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Y.; Alton, G.D. [Physics Division, Oak Ridge National Laboratory, Oak Ridge, TN (United States)

    2004-12-27

    In order to produce useful intensities of radioactive ion beams, ISOL targets must be designed that can withstand direct irradiation with high power beams. Computational thermal modeling techniques offer a cost effective way for evaluating prototype target concepts in the quest to find an optimum design. In this report, a number of codes are utilized to select target materials and to model the primary beam power density, thermal transport and temperature distributions in ISOL targets. These studies suggest that radiation cooling, in combination with Lissajous beam scan techniques, can be used to control temperatures in practically sized targets, to levels commensurate with irradiation with 1-GeV, 400-kW proton beams for next generation RIB facilities.

  10. Next-generation TCAP hydrogen isotope separation process

    International Nuclear Information System (INIS)

    Heung, L. K.; Sessions, H. T.; Poore, A. S.; Jacobs, W. D.; Williams, C. S.

    2008-01-01

    A thermal cycling absorption process (TCAP) for hydrogen isotope separation has been in operation at Savannah River Site since 1994. The process uses a hot/cold nitrogen system to cycle the temperature of the separation column. The hot/cold nitrogen system requires the use of large compressors, heat exchanges, valves and piping that is bulky and maintenance intensive. A new compact thermal cycling (CTC) design has recently been developed. This new design uses liquid nitrogen tubes and electric heaters to heat and cool the column directly so that the bulky hot/cold nitrogen system can be eliminated. This CTC design is simple and is easy to implement, and will be the next generation TCAP system at SRS. A twelve-meter column has been fabricated and installed in the laboratory to demonstrate its performance. The design of the system and its test results to date is discussed. (authors)

  11. NREL-Prime Next-Generation Drivetrain Dynamometer Test Report

    Energy Technology Data Exchange (ETDEWEB)

    Keller, Jonathan [National Renewable Energy Lab. (NREL), Golden, CO (United States); Erdman, Bill [Cinch, Inc., Moraga, CA (United States); Blodgett, Douglas [DNV KEMA Renewables, Burlington, VT (United States); Halse, Christopher [Romax Technology, Boulder, CO (United States)

    2016-08-01

    Advances in wind turbine drivetrain technologies are necessary to improve reliability and reduce the cost of energy for land-based and offshore wind turbines. The NREL-Prime Next-Generation Drivetrain team developed a geared, medium-speed drivetrain that is lighter, more reliable and more efficient than existing designs. One of the objectives of Phase II of the project was to complete the detailed design, fabrication, and dynamometer testing of a 750 kilowatt (kW) drivetrain that includes the key gearbox innovations designed by Romax Technology and power converter innovations designed by DNV Kema Renewables. The purpose of this document is to summarize these tests completed in NREL's National Wind Technology Center 2.5 megawatt (MW) dynamometer.

  12. W. M. Keck Observatory's next-generation adaptive optics facility

    Science.gov (United States)

    Wizinowich, P.; Adkins, S.; Dekany, R.; Gavel, D.; Max, C.; Bartos, R.; Bell, J.; Bouchez, A.; Chin, J.; Conrad, A.; Delacroix, A.; Johansson, E.; Kupke, R.; Lockwood, C.; Lyke, J.; Marchis, F.; McGrath, E.; Medeiros, D.; Morris, M.; Morrison, D.; Neyman, C.; Panteleev, S.; Pollard, M.; Reinig, M.; Stalcup, T.; Thomas, S.; Troy, M.; Tsubota, K.; Velur, V.; Wallace, K.; Wetherell, E.

    2010-07-01

    We report on the preliminary design of W.M. Keck Observatory's (WMKO's) next-generation adaptive optics (NGAO) facility. This facility is designed to address key science questions including understanding the formation and evolution of today's galaxies, measuring dark matter in our galaxy and beyond, testing the theory of general relativity in the Galactic Center, understanding the formation of planetary systems around nearby stars, and exploring the origins of our own solar system. The requirements derived from these science questions have resulted in NGAO being designed to have near diffraction-limited performance in the near-IR (K-Strehl ~ 80%) over narrow fields (benefit quantitative astronomy, a cooled science path to reduce thermal background, and a high-efficiency science instrument providing imaging and integral field spectroscopy.

  13. Reducing Risk for the Next Generation Nuclear Plant

    Energy Technology Data Exchange (ETDEWEB)

    John M. Beck II; Harold J. Heydt; Emmanuel O. Opare; Kyle B. Oswald

    2010-07-01

    The Next Generation Nuclear Plant (NGNP) Project, managed by the Idaho National Laboratory (INL), is directed by the Energy Policy Act of 2005, to research, develop, design, construct, and operate a prototype forth generation nuclear reactor to meet the needs of the 21st Century. As with all large projects developing and deploying new technologies, the NGNP has numerous risks that need to be identified, tracked, mitigated, and reduced in order for successful project completion. A Risk Management Plan (RMP) was created to outline the process the INL is using to manage the risks and reduction strategies for the NGNP Project. Integral to the RMP is the development and use of a Risk Management System (RMS). The RMS is a tool that supports management and monitoring of the project risks. The RMS does not only contain a risk register, but other functionality that allows decision makers, engineering staff, and technology researchers to review and monitor the risks as the project matures.

  14. Safety criteria for the next generation of European reactors

    International Nuclear Information System (INIS)

    Dominguez Bautista, M.T.

    1995-01-01

    For the next generation of reactors, European companies operating in the electricity sector have drawn up a document called European Utilities Requirement (EUR), which sets out the requirements to be met by the designers of future reactors. The main objective of these new requirements is to increase the safety in existing reactors, making good use of operating experience available and the technological developments of the last decade. This paper offers an in-depth analysis of the most significant characteristics, describing how the EUR requirements have been prepared and how they are being implemented by the designers. Areas covered are: - Combining deterministic and probabilistic criteria - Automation of control systems - Design extension for severe accidents - Containment design - Emergency plans - Autonomy versus manual operation

  15. An Operations Concept for the Next Generation VLA

    Science.gov (United States)

    Kepley, Amanda; McKinnon, Mark; Selina, Rob; Murphy, Eric Joseph; ngVLA project

    2018-01-01

    This poster presents an operations plan for the next generation VLA (ngVLA), which is a proposed 214 element interferometer operating from ~1-115GHz, located in the southwestern United States. The operations requirements for this instrument are driven by the large number of antennas spread out over a multi-state area and a cap on the operations budget of 3 times that of the current VLA. These constraints require that the maintenance is a continuous process and that individual antennas are self-sufficient, making flexible subarrays crucial. The ngVLA will produce science ready data products for its users, building on the pioneering work being currently done at ALMA and the JVLA. Finally, the ngVLA will adopt a user support model similar to those at other large facilities (ALMA, HST, JWST, etc).

  16. Testing gravity via next-generation lunar laser-ranging

    International Nuclear Information System (INIS)

    Murphy, T.W.; Adelberger, E.G.; Strasburg, J.D.; Stubbs, C.W.; Nordtvedt, K.

    2004-01-01

    Lunar laser ranging has a long history of performing the most precise tests of various gravitational phenomena, dating from the placement of retroreflector arrays on the lunar surface by the Apollo astronauts. Gravity is the least well understood of the fundamental forces of nature, our current model being incompatible with quantum mechanics. We must therefore push our tests of gravity further, with the expectation that general relativity will fail to reproduce exactly measurements of sufficient precision. We aim to improve lunar ranging performance by an order-of-magnitude, resulting in comparable sensitivity gains in various tests of the basic nature of gravity. Here we describe the scientific motivation and techniques behind this next-generation lunar ranging effort, APOLLO

  17. Metrology/viewing system for next generation fusion reactors

    International Nuclear Information System (INIS)

    Spampinato, P.T.; Barry, R.E.; Chesser, J.B.; Menon, M.M.; Dagher, M.A.

    1997-01-01

    Next generation fusion reactors require accurate measuring systems to verify sub-millimeter alignment of plasma-facing components in the reactor vessel. A metrology system capable of achieving such accuracy must be compatible with the vessel environment of high gamma radiation, high vacuum, elevated temperature, and magnetic field. This environment requires that the system must be remotely deployed. A coherent, frequency modulated laser radar system is being integrated with a remotely operated deployment system to meet these requirements. The metrology/viewing system consists of a compact laser transceiver optics module which is linked through fiber optics to the laser source and imaging units that are located outside of the harsh environment. The deployment mechanism is a telescopic-mast positioning system. This paper identifies the requirements for the International Thermonuclear Experimental Reactor metrology and viewing system, and describes a remotely operated precision ranging and surface mapping system

  18. Advanced LIGO: the next generation of gravitational wave detectors

    International Nuclear Information System (INIS)

    Harry, Gregory M

    2010-01-01

    The Advanced LIGO gravitational wave detectors are next generation instruments which will replace the existing initial LIGO detectors. They are currently being constructed and installed. Advanced LIGO strain sensitivity is designed to be about a factor 10 better than initial LIGO over a broad band and usable to 10 Hz, in contrast to 40 Hz for initial LIGO. This is expected to allow for detections and significant astrophysics in most categories of gravitational waves. To achieve this sensitivity, all hardware subsystems are being replaced with improvements. Designs and expected performance are presented for the seismic isolation, suspensions, optics and laser subsystems. Possible enhancements to Advanced LIGO, either to resolve problems that may arise and/or to allow for improved performance, are now being researched. Some of these enhancements are discussed along with some potential technology being considered for detectors beyond Advanced LIGO.

  19. The Next Generation ARC Middleware and ATLAS Computing Model

    CERN Document Server

    Filipcic, A; The ATLAS collaboration; Smirnova, O; Konstantinov, A; Karpenko, D

    2012-01-01

    The distributed NDGF Tier-1 and associated Nordugrid clusters are well integrated into the ATLAS computing model but follow a slightly different paradigm than other ATLAS resources. The current strategy does not divide the sites as in the commonly used hierarchical model, but rather treats them as a single storage endpoint and a pool of distributed computing nodes. The next generation ARC middleware with its several new technologies provides new possibilities in development of the ATLAS computing model, such as pilot jobs with pre-cached input files, automatic job migration between the sites, integration of remote sites without connected storage elements, and automatic brokering for jobs with non-standard resource requirements. ARC's data transfer model provides an automatic way for the computing sites to participate in ATLAS' global task management system without requiring centralised brokering or data transfer services. The powerful API combined with Python and Java bindings can easily be used to build new ...

  20. Implementation of Targeted Next Generation Sequencing in Clinical Diagnostics

    DEFF Research Database (Denmark)

    Larsen, Martin Jakob; Burton, Mark; Thomassen, Mads

    advantage of targeted NGS is that multiple disease-specific genes can easily be sequenced simultaneously, which is favorable in genetic heterogeneous diseases. Prior to implementation in our diagnostic setting, we aimed to assess the sensitivity and specificity of targeted NGS by sequencing a collection......, respectively. For diagnostics, the sequencing coverage is essential, wherefore a minimum coverage of 30x per nucleotide in the coding regions was used as our primary quality criterion. For the majority of the included genes, we obtained adequate gene coverage, in which we were able to detect 100% of the known......Accurate mutation detection is essential in clinical genetic diagnostics of monogenic hereditary diseases. Targeted next generation sequencing (NGS) provides a promising and cost-effective alternative to Sanger sequencing and MLPA analysis currently used in most diagnostic laboratories. One...

  1. Towards the next generation of simplified Dark Matter models

    Science.gov (United States)

    Albert, Andreas; Bauer, Martin; Brooke, Jim; Buchmueller, Oliver; Cerdeño, David G.; Citron, Matthew; Davies, Gavin; de Cosa, Annapaola; De Roeck, Albert; De Simone, Andrea; Du Pree, Tristan; Flaecher, Henning; Fairbairn, Malcolm; Ellis, John; Grohsjean, Alexander; Hahn, Kristian; Haisch, Ulrich; Harris, Philip C.; Khoze, Valentin V.; Landsberg, Greg; McCabe, Christopher; Penning, Bjoern; Sanz, Veronica; Schwanenberger, Christian; Scott, Pat; Wardle, Nicholas

    2017-06-01

    This White Paper is an input to the ongoing discussion about the extension and refinement of simplified Dark Matter (DM) models. It is not intended as a comprehensive review of the discussed subjects, but instead summarises ideas and concepts arising from a brainstorming workshop that can be useful when defining the next generation of simplified DM models (SDMM). In this spirit, based on two concrete examples, we show how existing SDMM can be extended to provide a more accurate and comprehensive framework to interpret and characterise collider searches. In the first example we extend the canonical SDMM with a scalar mediator to include mixing with the Higgs boson. We show that this approach not only provides a better description of the underlying kinematic properties that a complete model would possess, but also offers the option of using this more realistic class of scalar mixing models to compare and combine consistently searches based on different experimental signatures. The second example outlines how a new physics signal observed in a visible channel can be connected to DM by extending a simplified model including effective couplings. In the next part of the White Paper we outline other interesting options for SDMM that could be studied in more detail in the future. Finally, we review important aspects of supersymmetric models for DM and use them to propose how to develop more complete SDMMs. This White Paper is a summary of the brainstorming meeting "Next generation of simplified Dark Matter models" that took place at Imperial College, London on May 6, 2016, and corresponding follow-up studies on selected subjects.

  2. A Framework for the Next Generation of Risk Science

    Science.gov (United States)

    Krewski, Daniel; Andersen, Melvin E.; Paoli, Gregory M.; Chiu, Weihsueh A.; Al-Zoughool, Mustafa; Croteau, Maxine C.; Burgoon, Lyle D.; Cote, Ila

    2014-01-01

    Objectives: In 2011, the U.S. Environmental Protection Agency initiated the NexGen project to develop a new paradigm for the next generation of risk science. Methods: The NexGen framework was built on three cornerstones: the availability of new data on toxicity pathways made possible by fundamental advances in basic biology and toxicological science, the incorporation of a population health perspective that recognizes that most adverse health outcomes involve multiple determinants, and a renewed focus on new risk assessment methodologies designed to better inform risk management decision making. Results: The NexGen framework has three phases. Phase I (objectives) focuses on problem formulation and scoping, taking into account the risk context and the range of available risk management decision-making options. Phase II (risk assessment) seeks to identify critical toxicity pathway perturbations using new toxicity testing tools and technologies, and to better characterize risks and uncertainties using advanced risk assessment methodologies. Phase III (risk management) involves the development of evidence-based population health risk management strategies of a regulatory, economic, advisory, community-based, or technological nature, using sound principles of risk management decision making. Conclusions: Analysis of a series of case study prototypes indicated that many aspects of the NexGen framework are already beginning to be adopted in practice. Citation: Krewski D, Westphal M, Andersen ME, Paoli GM, Chiu WA, Al-Zoughool M, Croteau MC, Burgoon LD, Cote I. 2014. A framework for the next generation of risk science. Environ Health Perspect 122:796–805; http://dx.doi.org/10.1289/ehp.1307260 PMID:24727499

  3. Next generation sequencing reveals the hidden diversity of zooplankton assemblages.

    Directory of Open Access Journals (Sweden)

    Penelope K Lindeque

    Full Text Available BACKGROUND: Zooplankton play an important role in our oceans, in biogeochemical cycling and providing a food source for commercially important fish larvae. However, difficulties in correctly identifying zooplankton hinder our understanding of their roles in marine ecosystem functioning, and can prevent detection of long term changes in their community structure. The advent of massively parallel next generation sequencing technology allows DNA sequence data to be recovered directly from whole community samples. Here we assess the ability of such sequencing to quantify richness and diversity of a mixed zooplankton assemblage from a productive time series site in the Western English Channel. METHODOLOGY/PRINCIPLE FINDINGS: Plankton net hauls (200 µm were taken at the Western Channel Observatory station L4 in September 2010 and January 2011. These samples were analysed by microscopy and metagenetic analysis of the 18S nuclear small subunit ribosomal RNA gene using the 454 pyrosequencing platform. Following quality control a total of 419,041 sequences were obtained for all samples. The sequences clustered into 205 operational taxonomic units using a 97% similarity cut-off. Allocation of taxonomy by comparison with the National Centre for Biotechnology Information database identified 135 OTUs to species level, 11 to genus level and 1 to order, <2.5% of sequences were classified as unknowns. By comparison a skilled microscopic analyst was able to routinely enumerate only 58 taxonomic groups. CONCLUSIONS: Metagenetics reveals a previously hidden taxonomic richness, especially for Copepoda and hard-to-identify meroplankton such as Bivalvia, Gastropoda and Polychaeta. It also reveals rare species and parasites. We conclude that Next Generation Sequencing of 18S amplicons is a powerful tool for elucidating the true diversity and species richness of zooplankton communities. While this approach allows for broad diversity assessments of plankton it may

  4. Next-Generation Sequencing and Genome Editing in Plant Virology

    Directory of Open Access Journals (Sweden)

    Ahmed Hadidi

    2016-08-01

    Full Text Available Next-generation sequencing (NGS has been applied to plant virology since 2009. NGS provides highly efficient, rapid, low cost DNA or RNA high-throughput sequencing of the genomes of plant viruses and viroids and of the specific small RNAs generated during the infection process. These small RNAs, which cover frequently the whole genome of the infectious agent, are 21-24 nt long and are known as vsRNAs for viruses and vd-sRNAs for viroids. NGS has been used in a number of studies in plant virology including, but not limited to, discovery of novel viruses and viroids as well as detection and identification of those pathogens already known, analysis of genome diversity and evolution, and study of pathogen epidemiology. The genome engineering editing method, clustered regularly interspaced short palindromic repeats (CRISPR-Cas9 system has been successfully used recently to engineer resistance to DNA geminiviruses (family, Geminiviridae by targeting different viral genome sequences in infected Nicotiana benthamiana or Arabidopsis plants. The DNA viruses targeted include tomato yellow leaf curl virus and merremia mosaic virus (begomovirus; beet curly top virus and beet severe curly top virus (curtovirus; and bean yellow dwarf virus (mastrevirus. The technique has also been used against the RNA viruses zucchini yellow mosaic virus, papaya ringspot virus and turnip mosaic virus (potyvirus and cucumber vein yellowing virus (ipomovirus, family, Potyviridae by targeting the translation initiation genes eIF4E in cucumber or Arabidopsis plants. From these recent advances of major importance, it is expected that NGS and CRISPR-Cas technologies will play a significant role in the very near future in advancing the field of plant virology and connecting it with other related fields of biology.Keywords: Next-generation sequencing, NGS, plant virology, plant viruses, viroids, resistance to plant viruses by CRISPR-Cas9

  5. Passive Core Cooling Systems for Next Generation NPPs: Characteristics and State of the Art

    International Nuclear Information System (INIS)

    Morozov, Andrey; Soshkina, Alexandra

    2008-01-01

    Among nuclear power generation plants, light water reactors are mainly used at present, and are anticipated to be predominant in the future. To improve the light water reactors the development of the LWRs for the next generation is carried out at various organizations. For example, in the USA the Westinghouse AP-1000 is based on proven technology but with an emphasis on passive safety features. The reactor passive core cooling systems include the core makeup tanks system, passive residual heat removal heat exchanger and in-containment refuelling water storage tank. In Russia has been developed the so-called NPP-2006 project of a VVER-1200 nuclear power plant with a V-392M reactor unit. To provide the safety, protection passive systems which do not depend upon human errors are widely used in this project. Among these are hydro-tanks of the second stage and passive heat removal system. In the presented paper an overview of passive core cooling systems for next generation NPPs is given. (authors)

  6. Passive Core Cooling Systems for Next Generation NPPs: Characteristics and State of the Art

    Energy Technology Data Exchange (ETDEWEB)

    Morozov, Andrey; Soshkina, Alexandra [Institute for Physics and Power Engineering by A.I. Leypunsky, 1 Bondarenko sq. Obninsk, 249033 (Russian Federation)

    2008-07-01

    Among nuclear power generation plants, light water reactors are mainly used at present, and are anticipated to be predominant in the future. To improve the light water reactors the development of the LWRs for the next generation is carried out at various organizations. For example, in the USA the Westinghouse AP-1000 is based on proven technology but with an emphasis on passive safety features. The reactor passive core cooling systems include the core makeup tanks system, passive residual heat removal heat exchanger and in-containment refuelling water storage tank. In Russia has been developed the so-called NPP-2006 project of a VVER-1200 nuclear power plant with a V-392M reactor unit. To provide the safety, protection passive systems which do not depend upon human errors are widely used in this project. Among these are hydro-tanks of the second stage and passive heat removal system. In the presented paper an overview of passive core cooling systems for next generation NPPs is given. (authors)

  7. Is the $1000 Genome as Near as We Think? A Cost Analysis of Next-Generation Sequencing

    NARCIS (Netherlands)

    Nimwegen, K.J.M. van; Soest, R.A.; Veltman, J.A.; Nelen, M.R.; Wilt, G.J. van der; Peart-Vissers, L.E.L.M.; Grutters, J.P.C.

    2016-01-01

    BACKGROUND: The substantial technological advancements in next-generation sequencing (NGS), combined with dropping costs, have allowed for a swift diffusion of NGS applications in clinical settings. Although several commercial parties report to have broken the $1000 barrier for sequencing an entire

  8. Using next generation sequencing approaches for the isolation of simple sequence repeats (SSF) in the plant sciences

    Science.gov (United States)

    The application of next-generation sequencing (NGS) technologies for the development of simple sequence repeat (SSR) or microsatellite loci for genetic research in the botanical sciences is described. The major advantage of using NGS methods to isolate SSR loci is their ability to quickly and cost-e...

  9. Next generation sequencing assays for benthic monitoring of the environmental impact associated with salmon farming (pilot study)

    DEFF Research Database (Denmark)

    Pawlowski, Jan; Esling, Philippe; Lejzerowicz, Franck

    2015-01-01

    This report presents the study of foraminiferal and metazoan benthic community based on next-generation sequencing (NGS) of environmental DNA and RNA (eDNA/RNA). The objective of this study was to test the application of NGS assays for benthic monitoring of salmon farms in Norway, in order to ove...

  10. Safety design philosophy of the ABWR for the next generation LWRs

    International Nuclear Information System (INIS)

    Sato, Takashi; Akinaga, Makoto; Kojima, Yoshihiro

    2009-01-01

    The paper presents safety design philosophy of the advanced boiling water reactor (ABWR) to be reflected in developing the next generation light water reactors (LWRs). The basic policy of the ABWR safety design was to improve safety and reduce cost simultaneously by reflecting lessons learned of precursors, incidents and accidents that were beyond the design basis such as the Three Mile Island Unit 2 (TMI 2) accident. The ABWR is a fully active safety plant. The ABWR enhanced redundancy and diversity of active safety systems using probabilistic safety assessment (PSA) insights. It adopted a complete three division active emergency core cooling system (ECCS) and attained a very low core damage frequency (CDF) value of less than 10 -7 /ry for internal events. Only very small residual risks, if any, rather exist in external events such as an extremely large earthquake beyond the design basis. This is because external events can constitute a common cause that disables all the redundant active safety systems. Therefore, it is useless to add one more ECCS train and make a four division active ECCS for external events. Nowadays, however, fully passive safety LWRs are already established. Incorporating some of these passive safety systems we can also establish the next generation LWRs that are truly strong against external events. We can establish a plant that can survive a giant earthquake at least three days without AC power source, SA proof safety design that enables no containment failure and no evacuation to eliminate the residual risks. The same basic policy as the ABWR to improve safety and reduce cost simultaneously is again effective for the next generation LWRs. (author)

  11. Polymeric Nanocomposite Membranes for Next Generation Pervaporation Process: Strategies, Challenges and Future Prospects

    Directory of Open Access Journals (Sweden)

    Sagar Roy

    2017-09-01

    Full Text Available Pervaporation (PV has been considered as one of the most active and promising areas in membrane technologies in separating close boiling or azeotropic liquid mixtures, heat sensitive biomaterials, water or organics from its mixtures that are indispensable constituents for various important chemical and bio-separations. In the PV process, the membrane plays the most pivotal role and is of paramount importance in governing the overall efficiency. This article evaluates and collaborates the current research towards the development of next generation nanomaterials (NMs and embedded polymeric membranes with regard to its synthesis, fabrication and application strategies, challenges and future prospects.

  12. Cross-Layer Handover Scheme for Multimedia Communications in Next Generation Wireless Networks

    Directory of Open Access Journals (Sweden)

    Lin Chun-Cheng

    2010-01-01

    Full Text Available In order to achieve seamless handover for real-time applications in the IP Multimedia Subsystem (IMS of next generation network, a multiprotocol combined handover mechanism is proposed in this paper. We combine SIP (Session Initiation Protocol, FMIP (Fast Mobile IPv6 Protocol, and MIH (Media Independent Handover protocols by cross-layer design and optimize those protocols' signaling flows to improve the performance of vertical handover. Theoretical analysis and simulation results illustrate that our proposed mechanism performs better than the original SIP and MIH combined handover mechanism in terms of service interruption time and packet loss.

  13. Yleaf: software for human Y-chromosomal haplogroup inference from next generation sequencing data.

    Science.gov (United States)

    Ralf, Arwin; Montiel González, Diego; Zhong, Kaiyin; Kayser, Manfred

    2018-03-06

    Next generation sequencing (NGS) technologies offer immense possibilities given the large genomic data they simultaneously deliver. The human Y chromosome serves as good example how NGS benefits various applications in evolution, anthropology, genealogy and forensics. Prior to NGS, the Y-chromosome phylogenetic tree consisted of a few hundred branches, based on NGS data it now contains many thousands. The complexity of both, Y tree and NGS data provide challenges for haplogroup assignment. For effective analysis and interpretation of Y-chromosome NGS data, we present Yleaf, a publically available, automated, user-friendly software for high-resolution Y-chromosome haplogroup inference independently of library and sequencing methods.

  14. Advanced Wind Turbine Program Next Generation Turbine Development Project: June 17, 1997--April 30, 2005

    Energy Technology Data Exchange (ETDEWEB)

    GE Wind Energy, LLC

    2006-05-01

    This document reports the technical results of the Next Generation Turbine Development Project conducted by GE Wind Energy LLC. This project is jointly funded by GE and the U.S. Department of Energy's National Renewable Energy Laboratory.The goal of this project is for DOE to assist the U.S. wind industry in exploring new concepts and applications of cutting-edge technology in pursuit of the specific objective of developing a wind turbine that can generate electricity at a levelized cost of energy of $0.025/kWh at sites with an average wind speed of 15 mph (at 10 m height).

  15. ENDF/B-VII.0: Next Generation Evaluated Nuclear Data Library for Nuclear Science and Technology

    Science.gov (United States)

    Chadwick, M. B.; Obložinský, P.; Herman, M.; Greene, N. M.; McKnight, R. D.; Smith, D. L.; Young, P. G.; MacFarlane, R. E.; Hale, G. M.; Frankle, S. C.; Kahler, A. C.; Kawano, T.; Little, R. C.; Madland, D. G.; Moller, P.; Mosteller, R. D.; Page, P. R.; Talou, P.; Trellue, H.; White, M. C.; Wilson, W. B.; Arcilla, R.; Dunford, C. L.; Mughabghab, S. F.; Pritychenko, B.; Rochman, D.; Sonzogni, A. A.; Lubitz, C. R.; Trumbull, T. H.; Weinman, J. P.; Brown, D. A.; Cullen, D. E.; Heinrichs, D. P.; McNabb, D. P.; Derrien, H.; Dunn, M. E.; Larson, N. M.; Leal, L. C.; Carlson, A. D.; Block, R. C.; Briggs, J. B.; Cheng, E. T.; Huria, H. C.; Zerkle, M. L.; Kozier, K. S.; Courcelle, A.; Pronyaev, V.; van der Marck, S. C.

    2006-12-01

    We describe the next generation general purpose Evaluated Nuclear Data File, ENDF/B-VII.0, of recommended nuclear data for advanced nuclear science and technology applications. The library, released by the U.S. Cross Section Evaluation Working Group (CSEWG) in December 2006, contains data primarily for reactions with incident neutrons, protons, and photons on almost 400 isotopes, based on experimental data and theory predictions. The principal advances over the previous ENDF/B-VI library are the following: (1) New cross sections for U, Pu, Th, Np and Am actinide isotopes, with improved performance in integral validation criticality and neutron transmission benchmark tests; (2) More precise standard cross sections for neutron reactions on H, 6Li, 10B, Au and for 235,238U fission, developed by a collaboration with the IAEA and the OECD/NEA Working Party on Evaluation Cooperation (WPEC); (3) Improved thermal neutron scattering; (4) An extensive set of neutron cross sections on fission products developed through a WPEC collaboration; (5) A large suite of photonuclear reactions; (6) Extension of many neutron- and proton-induced evaluations up to 150 MeV; (7) Many new light nucleus neutron and proton reactions; (8) Post-fission beta-delayed photon decay spectra; (9) New radioactive decay data; (10) New methods for uncertainties and covariances, together with covariance evaluations for some sample cases; and (11) New actinide fission energy deposition. The paper provides an overview of this library, consisting of 14 sublibraries in the same ENDF-6 format as the earlier ENDF/B-VI library. We describe each of the 14 sublibraries, focusing on neutron reactions. Extensive validation, using radiation transport codes to simulate measured critical assemblies, show major improvements: (a) The long-standing underprediction of low enriched uranium thermal assemblies is removed; (b) The 238U and 208Pb reflector biases in fast systems are largely removed; (c) ENDF/B-VI.8 good

  16. ENDF/B-VII.0: Next Generation Evaluated Nuclear Data Library for Nuclear Science and Technology

    International Nuclear Information System (INIS)

    Chadwick, M.B.; Oblozinsky, P.; Herman, M.

    2006-01-01

    We describe the next generation general purpose Evaluated Nuclear Data File, ENDF/B-VII.0, of recommended nuclear data for advanced nuclear science and technology applications. The library, released by the U.S. Cross Section Evaluation Working Group (CSEWG) in December 2006, contains data primarily for reactions with incident neutrons, protons, and photons on almost 400 isotopes, based on experimental data and theory predictions. The principal advances over the previous ENDF/B-VI library are the following: (1) New cross sections for U, Pu, Th, Np and Am actinide isotopes, with improved performance in integral validation criticality and neutron transmission benchmark tests; (2) More precise standard cross sections for neutron reactions on H, 6 Li, 10 B, Au and for 235,238 U fission, developed by a collaboration with the IAEA and the OECD/NEA Working Party on Evaluation Cooperation (WPEC); (3) Improved thermal neutron scattering; (4) An extensive set of neutron cross sections on fission products developed through a WPEC collaboration; (5) A large suite of photonuclear reactions; (6) Extension of many neutron- and proton-induced evaluations up to 150 MeV; (7) Many new light nucleus neutron and proton reactions; (8) Post-fission beta-delayed photon decay spectra; (9) New radioactive decay data; (10) New methods for uncertainties and covariances, together with covariance evaluations for some sample cases; and (11) New actinide fission energy deposition. The paper provides an overview of this library, consisting of 14 sublibraries in the same ENDF-6 format as the earlier ENDF/B-VI library. We describe each of the 14 sublibraries, focusing on neutron reactions. Extensive validation, using radiation transport codes to simulate measured critical assemblies, show major improvements: (a) The long-standing underprediction of low enriched uranium thermal assemblies is removed; (b) The 238 U and 208 Pb reflector biases in fast systems are largely removed; (c) ENDF/B-VI.8 good

  17. ENDF/B-VII.0: Next Generation Evaluated Nuclear Data Library for Nuclear Science and Technology

    Energy Technology Data Exchange (ETDEWEB)

    Chadwick, M B; Oblozinsky, P; Herman, M; Greene, N M; McKnight, R D; Smith, D L; Young, P G; MacFarlane, R E; Hale, G M; Haight, R C; Frankle, S; Kahler, A C; Kawano, T; Little, R C; Madland, D G; Moller, P; Mosteller, R; Page, P; Talou, P; Trellue, H; White, M; Wilson, W B; Arcilla, R; Dunford, C L; Mughabghab, S F; Pritychenko, B; Rochman, D; Sonzogni, A A; Lubitz, C; Trumbull, T H; Weinman, J; Brown, D; Cullen, D E; Heinrichs, D; McNabb, D; Derrien, H; Dunn, M; Larson, N M; Leal, L C; Carlson, A D; Block, R C; Briggs, B; Cheng, E; Huria, H; Kozier, K; Courcelle, A; Pronyaev, V; der Marck, S

    2006-10-02

    We describe the next generation general purpose Evaluated Nuclear Data File, ENDF/B-VII.0, of recommended nuclear data for advanced nuclear science and technology applications. The library, released by the U.S. Cross Section Evaluation Working Group (CSEWG) in December 2006, contains data primarily for reactions with incident neutrons, protons, and photons on almost 400 isotopes. The new evaluations are based on both experimental data and nuclear reaction theory predictions. The principal advances over the previous ENDF/B-VI library are the following: (1) New cross sections for U, Pu, Th, Np and Am actinide isotopes, with improved performance in integral validation criticality and neutron transmission benchmark tests; (2) More precise standard cross sections for neutron reactions on H, {sup 6}Li, {sup 10}B, Au and for {sup 235,238}U fission, developed by a collaboration with the IAEA and the OECD/NEA Working Party on Evaluation Cooperation (WPEC); (3) Improved thermal neutron scattering; (4) An extensive set of neutron cross sections on fission products developed through a WPEC collaboration; (5) A large suite of photonuclear reactions; (6) Extension of many neutron- and proton-induced reactions up to an energy of 150 MeV; (7) Many new light nucleus neutron and proton reactions; (8) Post-fission beta-delayed photon decay spectra; (9) New radioactive decay data; and (10) New methods developed to provide uncertainties and covariances, together with covariance evaluations for some sample cases. The paper provides an overview of this library, consisting of 14 sublibraries in the same, ENDF-6 format, as the earlier ENDF/B-VI library. We describe each of the 14 sublibraries, focusing on neutron reactions. Extensive validation, using radiation transport codes to simulate measured critical assemblies, show major improvements: (a) The long-standing underprediction of low enriched U thermal assemblies is removed; (b) The {sup 238}U, {sup 208}Pb, and {sup 9}Be reflector

  18. Transmission of multi-dimensional signals for next generation optical communication systems

    Science.gov (United States)

    Yi, Anlin; Yan, Lianshan; Pan, Yan; Jiang, Lin; Chen, Zhiyu; Pan, Wei; Luo, Bin

    2018-02-01

    Over the past several decades, the data-carrying capacity of a single optical fiber have been increased significantly by fully exploring and optimizing physical dimensions of the light. Generally there are five major candidates of dimensions, including time, wavelength, polarization, space and quadrature (phase and amplitude). Multi-dimension, utilizing more than two dimensions of the light simultaneously, is one of the essential characteristics of next generation optical communication systems. We review recent advances in transmission of multi-dimensional signals, and highlight innovative ways of exploring the polarization dimension to further increase the capacity or spectral efficiency of a single optical fiber, a so-called pseudo-polarization-division-multiplexing (PPDM) technique. Related demonstrations include non-orthogonal PDM, PPDM of three and four states (PPDM-3 and PPDM-4). Brief discussions on trends of multi-dimensional signal transmission technologies are also presented.

  19. Dependable Hydrogen and Industrial Heat Generation from the Next Generation Nuclear Plant

    Energy Technology Data Exchange (ETDEWEB)

    Charles V. Park; Michael W. Patterson; Vincent C. Maio; Piyush Sabharwall

    2009-03-01

    The Department of Energy is working with industry to develop a next generation, high-temperature gas-cooled nuclear reactor (HTGR) as a part of the effort to supply the US with abundant, clean and secure energy. The Next Generation Nuclear Plant (NGNP) project, led by the Idaho National Laboratory, will demonstrate the ability of the HTGR to generate hydrogen, electricity, and high-quality process heat for a wide range of industrial applications. Substituting HTGR power for traditional fossil fuel resources reduces the cost and supply vulnerability of natural gas and oil, and reduces or eliminates greenhouse gas emissions. As authorized by the Energy Policy Act of 2005, industry leaders are developing designs for the construction of a commercial prototype producing up to 600 MWt of power by 2021. This paper describes a variety of critical applications that are appropriate for the HTGR with an emphasis placed on applications requiring a clean and reliable source of hydrogen. An overview of the NGNP project status and its significant technology development efforts are also presented.

  20. AgMIP: Next Generation Models and Assessments

    Science.gov (United States)

    Rosenzweig, C.

    2014-12-01

    Next steps in developing next-generation crop models fall into several categories: significant improvements in simulation of important crop processes and responses to stress; extension from simplified crop models to complex cropping systems models; and scaling up from site-based models to landscape, national, continental, and global scales. Crop processes that require major leaps in understanding and simulation in order to narrow uncertainties around how crops will respond to changing atmospheric conditions include genetics; carbon, temperature, water, and nitrogen; ozone; and nutrition. The field of crop modeling has been built on a single crop-by-crop approach. It is now time to create a new paradigm, moving from 'crop' to 'cropping system.' A first step is to set up the simulation technology so that modelers can rapidly incorporate multiple crops within fields, and multiple crops over time. Then the response of these more complex cropping systems can be tested under different sustainable intensification management strategies utilizing the updated simulation environments. Model improvements for diseases, pests, and weeds include developing process-based models for important diseases, frameworks for coupling air-borne diseases to crop models, gathering significantly more data on crop impacts, and enabling the evaluation of pest management strategies. Most smallholder farming in the world involves integrated crop-livestock systems that cannot be represented by crop modeling alone. Thus, next-generation cropping system models need to include key linkages to livestock. Livestock linkages to be incorporated include growth and productivity models for grasslands and rangelands as well as the usual annual crops. There are several approaches for scaling up, including use of gridded models and development of simpler quasi-empirical models for landscape-scale analysis. On the assessment side, AgMIP is leading a community process for coordinated contributions to IPCC AR6