Implementing Cisco UCS solutions

CERN Document Server

Ahmed, Farhan

2013-01-01

A tutorial-based approach which will help you understand the practical methodologies and deploying of Cisco UCS components.If you are a professional such as a system, network, or storage administrator who is responsible for Cisco UCS deployments, this is the perfect book for you. You should have some basic knowledge of the server's architecture, network, and storage technologies. Familiarity with virtualization technologies is also recommended (though not necessary) as the majority of real-world UCS deployments run virtualized loads. Knowledge of Nexus OS is not necessary as the majority of th

Codifying a Next-Generation Education System: Jefferson Parish Public School System

Science.gov (United States)

Education Development Center, Inc, 2009

2009-01-01

Using innovative strategies in collaboration with national and international education partners and school districts in Mississippi and Louisiana, Cisco Systems, Inc. (Cisco), has experimented with 21st Century education system reform ideas and strategies for the past four years. The Cisco 21S Initiative seeks to transform current approaches to…

CCNA Cisco Certified Network Associate Study Guide

CERN Document Server

Lammle, Todd

2011-01-01

Learn from the Best - Cisco Networking Authority Todd LammleWritten by Cisco networking authority Todd Lammle, this comprehensive guide has been completely updated to reflect the latest CCNA 640-802 exam. Todd's straightforward style provides lively examples, hands on and written labs, easy-to-understand analogies, and real-world scenarios that will not only help you prepare for the exam, but also give you a solid foundation as a Cisco networking professional.This Study Guide teaches you how toDescribe how a network worksConfigure, verify and troubleshoot a switch with VLANs and interswitch co

A Customer Relationship Management System to Target Customers at Cisco

OpenAIRE

Rahul Bhaskar

2004-01-01

This case describes the implementation of an Internet empowered Customer Relationship Management (CRM) at Cisco Systems Inc. After describing the organizational background of Cisco, the case takes the student into the issues that the executives faced after the market crash in 2001. John Chambers, Cisco CEO, and his team decided to strengthen Cisco’s relationship with the customers so that the company could emerge stronger when the markets recovered. Questions are raised as to the implementa...

Simulation and Validation of Cisco Lethal Conditions in Minnesota Lakes under Past and Future Climate Scenarios Using Constant Survival Limits

Directory of Open Access Journals (Sweden)

Liping Jiang

2016-07-01

Full Text Available Fish habitat in lakes is strongly constrained by water temperature (T and available dissolved oxygen (DO that are changed under climate warming. A one dimensional, dynamic water quality model MINLAKE2012 was used for T and DO simulation over 48 years. A fish habitat model FishHabitat2013 using simulated T and DO profiles as input was developed to determine lethal conditions of cisco Corgenous artedi in Minnesota lakes. Twenty-three lakes that had observations of cisco mortality or survival in the unusually warm summer of 2006 were used for model validation. The cisco habitat model used a lethal temperature of 22.1 °C and DO survival limit of 3 mg/L determined through model validation and sensitivity analysis. Cisco lethal conditions in 12 shallow, 16 medium-depth, and 30 deep virtual lakes were then simulated. Isopleths of total number of years with cisco kill and average cisco kill days for the years with kills under past (1961–2008 and future climate were generated to understand/extrapolate climate impacts on cisco in 620 Minnesota lakes. Shallow and medium-depth lakes are projected to not be good candidates for cisco refuge lakes, but deep lakes are possible cisco refuge lakes based on lethal condition projection under future warmer climate.

Auto-Configuration of Cisco Routers with Application Software

National Research Council Canada - National Science Library

Prado, Alexandre

2003-01-01

.... These parameters are dynamic, so they must be uploaded into the Cisco routers to take effect. The focus is on determining the most efficient way of communicating between the Cisco routers and the SAAM system...

Temperature tolerance of young-of-the-year cisco, Coregonus artedii

Science.gov (United States)

Edsall, Thomas A.; Colby, Peter J.

1970-01-01

Young-of-the-year ciscoes (Coregonus artedii) acclimated to 2, 5, 10, 20 and 25 C and tested for tolerance to high and low temperatures provide the first detailed description of the thermal tolerance of coregonids in North America. The upper ultimate lethal temperature of the young ciscoes was 26 C (6 C higher than the maximum sustained temperature tolerated by adult ciscoes in nature) and the ultimate lower lethal temperature approached 0 C (near that commonly tolerated in nature by adult ciscoes). The temperature of 26 C is slightly higher than the lowest ultimate upper lethal temperature recorded for North American freshwater fishes; however, published information on the depth distributions of fishes in the Great Lakes suggests that some of the other coregonids may be less tolerant of high temperatures than the cisco.

Application of Cisco Packet Trace in the Inter-VLAN Communication Teaching%浅析Cisco Packet Tracer在Vlan间通信教学的应用

Institute of Scientific and Technical Information of China (English)

郑耿凡

2014-01-01

Cisco Packet Tracer is a network simulation platform developed by Cisco Company. And Cisco packet tracer 5.3 allows three layer switch vlan communication in the experimental teaching. Real equipment is replaced by the analog simulation software, which solves the problem of lacking teaching experimental equipment in practice and im-proves the quality of teaching.%Cisco packet tracer是由思科公司开发的一个网络模拟辅助平台，在实验教学中可以借助Cisco packet tracer5.3实现三层交换机Vlan间通信，通过模拟防真软件来代替现实的设备，以解决在实践教学中实验设备缺乏的问题，提高教学质量。

Molecular Characterization of Transgenic Events Using Next Generation Sequencing Approach.

Science.gov (United States)

Guttikonda, Satish K; Marri, Pradeep; Mammadov, Jafar; Ye, Liang; Soe, Khaing; Richey, Kimberly; Cruse, James; Zhuang, Meibao; Gao, Zhifang; Evans, Clive; Rounsley, Steve; Kumpatla, Siva P

2016-01-01

Demand for the commercial use of genetically modified (GM) crops has been increasing in light of the projected growth of world population to nine billion by 2050. A prerequisite of paramount importance for regulatory submissions is the rigorous safety assessment of GM crops. One of the components of safety assessment is molecular characterization at DNA level which helps to determine the copy number, integrity and stability of a transgene; characterize the integration site within a host genome; and confirm the absence of vector DNA. Historically, molecular characterization has been carried out using Southern blot analysis coupled with Sanger sequencing. While this is a robust approach to characterize the transgenic crops, it is both time- and resource-consuming. The emergence of next-generation sequencing (NGS) technologies has provided highly sensitive and cost- and labor-effective alternative for molecular characterization compared to traditional Southern blot analysis. Herein, we have demonstrated the successful application of both whole genome sequencing and target capture sequencing approaches for the characterization of single and stacked transgenic events and compared the results and inferences with traditional method with respect to key criteria required for regulatory submissions.

Molecular Characterization of Transgenic Events Using Next Generation Sequencing Approach.

Directory of Open Access Journals (Sweden)

Satish K Guttikonda

Full Text Available Demand for the commercial use of genetically modified (GM crops has been increasing in light of the projected growth of world population to nine billion by 2050. A prerequisite of paramount importance for regulatory submissions is the rigorous safety assessment of GM crops. One of the components of safety assessment is molecular characterization at DNA level which helps to determine the copy number, integrity and stability of a transgene; characterize the integration site within a host genome; and confirm the absence of vector DNA. Historically, molecular characterization has been carried out using Southern blot analysis coupled with Sanger sequencing. While this is a robust approach to characterize the transgenic crops, it is both time- and resource-consuming. The emergence of next-generation sequencing (NGS technologies has provided highly sensitive and cost- and labor-effective alternative for molecular characterization compared to traditional Southern blot analysis. Herein, we have demonstrated the successful application of both whole genome sequencing and target capture sequencing approaches for the characterization of single and stacked transgenic events and compared the results and inferences with traditional method with respect to key criteria required for regulatory submissions.

Cisco CCNA/CCENT Exam 640-802, 640-822, 640-816 Preparation Kit With Cisco Router Simulations

CERN Document Server

Liu, Dale

2009-01-01

Three exams, two certifications, one complete Cisco training solution for networking professionals! .. .. The CCNA exam is an entry-level IT certification from Cisco Systems for professionals installing and maintaining route and switched networks. The current exam material covers networking concepts along with new and updated content on network security fundamentals and the basics of wireless networking. .. .. This book can be used as a study guide for either track you choose to receive your CCNA – the single exam, 640-802 or the combined 640-822 and 640-816, and for the CCENT certification wh

Spawning habitat unsuitability: an impediment to cisco rehabilitation in Lake Michigan?

Science.gov (United States)

Madenjian, Charles P.; Rutherford, Edward S.; Blouin, Marc A.; Sederberg, Bryan J.; Elliott, Jeff R.

2011-01-01

The cisco Coregonus artedi was one of the most important native prey fishes in Lake Michigan and in the other four Laurentian Great Lakes. Most of the cisco spawning in Lake Michigan was believed to have occurred in Green Bay. The cisco population in Lake Michigan collapsed during the 1950s, and the collapse was attributed in part to habitat degradation within Green Bay. Winter water quality surveys of lower Green Bay during the 1950s and 1960s indicated that the bottom dissolved oxygen (DO) concentration was less than 2 mg/L throughout much of the lower bay, and most cisco eggs would not successfully hatch at such low DO concentrations. To determine present-day spawning habitat suitability in lower Green Bay, we compared cisco egg survival in lower Green Bay with survival at a reference site (St. Marys River, Michigan–Ontario) during 2009. We also conducted winter water quality surveys in lower Green Bay and the St. Marys River during 2009 and 2010. Cisco egg survival in lower Green Bay averaged 65.3%, which was remarkably similar to and not significantly different from the mean at the St. Marys River site (64.0%). Moreover, the lowest bottom DO concentrations recorded during the winter surveys were 11.2 mg/L in lower Green Bay and 12.7 mg/L in the St. Marys River. These relatively high DO concentrations would not be expected to have any negative effect on cisco egg survival. We conclude that winter water quality conditions in lower Green Bay were suitable for successful hatching of cisco eggs and that water quality during the egg incubation period did not represent an impediment to cisco rehabilitation in Lake Michigan. Our approach to determining spawning habitat suitability for coregonids would be applicable to other aquatic systems.

Monte-Carlo event generation for the LHC

CERN Document Server

Siegert, Frank

This thesis discusses recent developments for the simulation of particle physics in the light of the start-up of the Large Hadron Collider. Simulation programs for fully exclusive events, dubbed Monte-Carlo event generators, are improved in areas related to the perturbative as well as non-perturbative regions of strong interactions. A short introduction to the main principles of event generation is given to serve as a basis for the following discussion. An existing algorithm for the correction of parton-shower emissions with the help of exact tree-level matrix elements is revisited and significantly improved as attested by first results. In a next step, an automated implementation of the POWHEG method is presented. It allows for the combination of parton showers with full next-to-leading order QCD calculations and has been tested in several processes. These two methods are then combined into a more powerful framework which allows to correct a parton shower with full next-to-leading order matrix elements and h...

Perancangan & Simlasi Security LAN Dengan Perangkat CISCO

OpenAIRE

Asma, Nur

2013-01-01

Perancangan ini dikembangkan dengan menggunakan perangkat lunak CISCO paket tracer. Biasanya dalam satu gedung fakultas mahasiswa berada dalam satu LAN sedangkan komputer dosen berada pada LAN lain. Hal ini sepertinya sudah sewajarna terjadi mengingat keadaan jaringan yang terhubung secara fisik. Jadi tujuan perancangan ini adalah membangun sistem keamanan LAN dengan sistem VLAN dan dijalankan dengan perangkat CISCO dari paket tracer. VLAN (Virtual Local Area Network) merupakan salah satu tek...

Mark retention of calcein in Cisco and Bloater

Science.gov (United States)

Chalupnicki, Marc A.; Mackey, Gregg; Nash, Kendra; Chiavelli, Richard; Johnson, James H.; Kehler, Thomas; Ringler, Neil H.

2016-01-01

Since 2012, a multi-agency initiative to restore these native forage species has been under way. Evaluating the restoration success of Cisco Coregonus artedi and Bloater C. hoyi in Lake Ontario waters requires methods to identify stocked fish. However, juvenile Cisco and Bloater are fragile; thus, mass marking techniques that reduce the handling of individual fish are required and have not previously been evaluated. In 2014–2015 we evaluated the usefulness of calcein (SE-MARK) as a marker on bony structures, including the otolith. Juvenile Bloater and Cisco (14, 100, 128 d old) were immersed in a calcein bath at 5,000 mg/L of water for 4 min to apply the chemical marker. Observations of the marking retention were evaluated 8 d following the treatment. All fish immersed in calcein had strong brilliant marks (rating scale 3) on all bony structures including scales, fin rays, jaw bones, and vertebrate. The otolith was the only hard structure that did not show a brilliant marking due to the opaque nature of the structure. Our results suggest that calcein produces a strong discernable mark on hard bony structures of Cisco and Bloater; however, long-term retention needs further study.

Top quark event modelling and generators

CERN Document Server

Rahmat, Rahmat

2016-01-01

State-of-the-art theoretical predictions accurate to next-to-leading order QCD interfaced with Pythia8 and Herwig++ event generators are tested by comparing the unfolded ttbar differential data collected with the CMS detector at 8 TeV. These predictions are also compared with the underlying event activity distributions in ttbar events using CMS proton-proton data collected in 2015 at a center of mass energy of 13 TeV.

Next-generation phylogenomics

Directory of Open Access Journals (Sweden)

Chan Cheong Xin

2013-01-01

Full Text Available Abstract Thanks to advances in next-generation technologies, genome sequences are now being generated at breadth (e.g. across environments and depth (thousands of closely related strains, individuals or samples unimaginable only a few years ago. Phylogenomics – the study of evolutionary relationships based on comparative analysis of genome-scale data – has so far been developed as industrial-scale molecular phylogenetics, proceeding in the two classical steps: multiple alignment of homologous sequences, followed by inference of a tree (or multiple trees. However, the algorithms typically employed for these steps scale poorly with number of sequences, such that for an increasing number of problems, high-quality phylogenomic analysis is (or soon will be computationally infeasible. Moreover, next-generation data are often incomplete and error-prone, and analysis may be further complicated by genome rearrangement, gene fusion and deletion, lateral genetic transfer, and transcript variation. Here we argue that next-generation data require next-generation phylogenomics, including so-called alignment-free approaches. Reviewers Reviewed by Mr Alexander Panchin (nominated by Dr Mikhail Gelfand, Dr Eugene Koonin and Prof Peter Gogarten. For the full reviews, please go to the Reviewers’ comments section.

Morphological and genetic features of cisco (coregonidae: coregonus sp. from lake Sobachye (Putorana plateau

Directory of Open Access Journals (Sweden)

Elena A. Borovikova

2016-09-01

Full Text Available Background. Recently was revealed that cisco from Lake Sobachye (Putorana Plateau is more similar to Coregonus albula Linnaeuas than C. sardinella Valenciennes according to number of vertebrae [13]. The aim of this work was to investigate molecular genetic features of this population.  Materials and methods. For morphological analysis were used 60 specimens of cisco from Lake Sobachye. For nine specimens molecular genetic analysis was performed. The sequences of two fragments of the mitochondrial DNA (ND1 and COI were defined.  Results. The cisco of the Lake Sobachye significantly differed from riverine cisco of this region by meristic features (namely from cisco of the River Pyasina. Sequencing results showed the minimal divergence of the ND1 and COI sequences of the cisco from Lake Sobachye and vendace.  Conclusion. Morphological analysis and analysis of the mitochondrial DNA polymorphism of cisco from Lake Sobachye revealed close relationship of this population to C. albula.

2008 Spawning Cisco Investigations in the Canadian Waters of Lake Superior

Science.gov (United States)

Yule, Daniel; Addison, Peter A.; Evrard, Lori M.; Cullis, Ken I.; Cholwek, Gary A.

2009-01-01

The Great Lakes Science Center of the United States Geological Survey (USGS) is working cooperatively with the Ontario Ministry of Natural Resources (OMNR) on a threeyear study to develop standard procedures for acoustic and midwater trawl (AC-MT) assessments of spawning cisco Coregonus artedi that the OMNR can carry forward as a management activity. In year two (2008), we conducted an AC-MT survey of the northern shore from Nipigon Bay to Thunder Bay. Spawning-cisco (> 250 mm total length) densities were lowest near Nipigon Bay (cisco in Thunder Bay during the 2008 fishery at 4% for ages 1-5, 8.7% for ages 6-12, and 4.4% for ages ≥ 13. Lake Superior fishery managers recently recommended that annual exploitation of adult female lake cisco be kept below 10-15%. Recruitment of cisco since 2003 has been low and there is a strong probability the Thunder Bay stock will decline into the future. Using a simple population dynamics approach we estimated that if the current total allowable catch (TAC) quota is held constant, exploitation fractions could exceed 10% by 2010 and 15% by 2011. Our 2008 collections suggested the survey of Black Bay was likely conducted before all spawners had returned there to spawn. Our data also suggested that cisco collected in Black Bay and east of this site in mid-November may be from the same stock. During November 2009 we will attempt to get better definition of the area occupied by cisco around Black Bay and also determine when surveys should be conducted at this location.

Perancangan dan Simulasi Security LAN dengan Perangkat Cisco

OpenAIRE

Asma, Nur

2015-01-01

Perancangan ini dikembangkan dengan menggunakan perangkat lunak CISCO paket tracer. Biasanya dalam satu gedung fakultas mahasiswa berada dalam satu LAN sedangkan komputer dosen berada pada LAN lain. Hal ini sepertinya sudah sewajarna terjadi mengingat keadaan jaringan yang terhubung secara fisik. Jadi tujuan perancangan ini adalah membangun sistem keamanan LAN dengan sistem VLAN dan dijalankan dengan perangkat CISCO dari paket tracer. VLAN (Virtual Local Area Network) merupakan salah satu tek...

Special Issue: Next Generation DNA Sequencing

Directory of Open Access Journals (Sweden)

Paul Richardson

2010-10-01

Full Text Available Next Generation Sequencing (NGS refers to technologies that do not rely on traditional dideoxy-nucleotide (Sanger sequencing where labeled DNA fragments are physically resolved by electrophoresis. These new technologies rely on different strategies, but essentially all of them make use of real-time data collection of a base level incorporation event across a massive number of reactions (on the order of millions versus 96 for capillary electrophoresis for instance. The major commercial NGS platforms available to researchers are the 454 Genome Sequencer (Roche, Illumina (formerly Solexa Genome analyzer, the SOLiD system (Applied Biosystems/Life Technologies and the Heliscope (Helicos Corporation. The techniques and different strategies utilized by these platforms are reviewed in a number of the papers in this special issue. These technologies are enabling new applications that take advantage of the massive data produced by this next generation of sequencing instruments. [...

Cisco (Coregonus artedii) mortalities in a southern Michigan lake, July 1968

Science.gov (United States)

Colby, Peter J.; Brooke, Larry T.

1969-01-01

Cisco die-offs are common in the summer in certain lakes of northern Indiana and southern Michigan, along the southern boundary of the national distribution of coregonine fishes. Although numerous cisco die-offs have been reported, few, if any, have been accompanied by environmental information at the time of the die-off. On 31 July and 1 August 1968, we investigated a cisco die-off on Halfmoon Lake, on the border of Washtenaw and Livingston Counties, Michigan.

Status of the shortjaw cisco (Coregonus zenithicus) in Lake Superior

Science.gov (United States)

Hoff, Michael H.; Todd, Thomas N.

2004-01-01

The shortjaw cisco (Coregonus zenithicus) was historically found in Lakes Huron, Michigan, and Superior, but has been extirpated in Lakes Huron and Michigan apparently as the result of commercial overharvest. During 1999-2001, we conducted an assessment of shortjaw cisco abundance in five areas, spanning the U.S. waters of Lake Superior, and compared our results with the abundance measured at those areas in 1921-1922. The shortjaw cisco was found at four of the five areas sampled, but abundances were so low that they were not significantly different from zero. In the four areas where shortjaw ciscoes were found, abundance declined significantly by 99% from the 1920s to the present. To increase populations of this once economically and ecologically important species in Lake Superior, an interagency rehabilitation effort is needed. Population monitoring is recommended to assess population trends and to evaluate success of rehabilitation efforts.

Refuge Lake Reclassification in 620 Minnesota Cisco Lakes under Future Climate Scenarios

Directory of Open Access Journals (Sweden)

Liping Jiang

2017-09-01

Full Text Available Cisco (Coregonus artedi is the most common coldwater stenothermal fish in Minnesota lakes. Water temperature (T and dissolved oxygen (DO in lakes are important controls of fish growth and reproduction and likely change with future climate warming. Built upon a previous study, this study uses a modified method to identify which of 620 cisco lakes in Minnesota can still support cisco populations under future climate and therefore be classified as cisco refuge lakes. The previous study used oxythermal stress parameter TDO3, the temperature at DO of 3 mg/L, simulated only from deep virtual lakes to classify 620 cisco lakes. Using four categories of virtual but representative cisco lakes in modified method, a one-dimensional water quality model MINLAKE2012 was used to simulate daily T and DO profiles in 82 virtual lakes under the past (1961–2008 and two future climate scenarios. A multiyear average of 31-day largest TDO3 over variable benchmark (VB periods, AvgATDO3VB, was calculated from simulated T and DO profiles using FishHabitat2013. Contour plots of AvgATDO3VB for four categories of virtual lakes were then developed to reclassify 620 cisco lakes into Tier 1 (AvgATDO3VB < 11 °C or Tier 2 refuge lakes, and Tier 3 non-refuge lakes (AvgATDO3VB > 17 °C. About 20% of 620 cisco lakes are projected to be refuge lakes under future climate scenarios, which is a more accurate projection (improving the prediction accuracy by ~6.5% from the previous study since AvgATDO3VB was found to vary by lake categories.

CCNA Cisco Certified Network Associate Study Guide: Exam 640-801

CERN Document Server

Lammle, Todd

2006-01-01

Here's the book you need to prepare for Cisco's revised CCNA exam, 640-801. This new edition of the best-selling CCNA Study Guide provides in-depth coverage of every CCNA exam objective, practical information on Cisco internetworking solutions and hundreds of challenging review questions.

Decline of shortjaw cisco in Lake Superior: the role of overfishing and risk of extinction

Science.gov (United States)

Bronte, Charles R.; Hoff, Michael H.; Gorman, Owen T.; Thogmartin, Wayne E.; Schneeberger, Philip J.; Todd, Thomas N.

2010-01-01

Recent reviews have further documented the decline of the shortjaw cisco Coregonus zenithicus in Lake Superior. This fish was the most abundant deepwater cisco species in Lake Superior in the early 1920s but presently makes up less than 1% of all deepwater ciscoes (i.e., including shortjaw cisco, bloater C. hoyi, and kiyi C. kiyi) captured in biological surveys. Directed overfishing of deepwater cisco species during the 1930s and again during the mid-1960s and 1970s has been suggested as the cause of the shortjaw cisco's demise. In this paper, we re-examined the overfishing hypothesis by using historical and recent survey data to estimate the proportion of the historical commercial fishery landings that comprised shortjaw ciscoes. We developed time series of estimated harvest and relative abundance for all statistical districts in Michigan waters of Lake Superior during 1929–1996, for which aggregate catch and effort data were available but not previously examined. The spatial distribution of the fishery and the relationships of catch to fishing effort were examined for evidence of overfishing. Our analysis suggested that directed overfishing was probably not the cause of shortjaw cisco demise, as this species appeared to be declining in all statistical districts regardless of the intensity of the fishery. A count-based population viability analysis indicated that quasi-extinction of the shortjaw cisco is highly probable in the near future. We propose an alternative hypothesis based on the decline of Lake Superior's keystone predator, the lake trout Salvelinus namaycush, which resulted in an expansion of the population of its principal prey, the cisco C. artedi, due to release from predation pressure. Competitive or predation interactions between the cisco and shortjaw cisco may be more likely explanations for the demise of the latter species.

Confirmation of cisco spawning in Chaumont Bay, Lake Ontario using an egg pumping device

Science.gov (United States)

George, Ellen M.; Stott, Wendylee; Young, Brian; Karboski, Curtis T.; Crabtree, Darran L.; Roseman, Edward; Rudstam, Lars G.

2017-01-01

Cisco Coregonus artedi, a historically abundant and commercially important fish in the Great Lakes, have declined drastically in the last century due to the impacts of invasive species, overfishing, and habitat degradation. Chaumont Bay, New York is believed to contain one of the last remaining spawning populations of cisco in Lake Ontario although direct evidence of spawning has remained elusive. We document cisco spawning in Chaumont Bay for the first time in decades through the use of an egg pumping device specifically developed to sample through lake ice. Forty-one eggs were identified as cisco using genetic barcoding of the mitochondrial cytochrome c oxidase I (COI) gene. Cisco eggs were associated with shallow, rocky shoals. Contemporary knowledge of spawning behavior is an important step toward the successful restoration of cisco in Lake Ontario and across the Great Lakes.

Preparing the Next Generation of Educators for Democracy

Science.gov (United States)

Embry-Jenlink, Karen

2018-01-01

In the keynote address of the 42nd annual meeting of the Southeastern Regional Educators Association (SRATE), ATE President Karen Embry-Jenlink examines the critical role of teacher educators in preparing the next generation of citizens and leaders to sustain democracy. Drawing from historic and current events and personal experience,…

Cisco Router and Switch Forensics Investigating and Analyzing Malicious Network Activity

CERN Document Server

Liu, Dale

2009-01-01

Cisco IOS (the software that runs the vast majority of Cisco routers and all Cisco network switches) is the dominant routing platform on the Internet and corporate networks. This widespread distribution, as well as its architectural deficiencies, makes it a valuable target for hackers looking to attack a corporate or private network infrastructure. Compromised devices can disrupt stability, introduce malicious modification, and endanger all communication on the network. For security of the network and investigation of attacks, in-depth analysis and diagnostics are critical, but no book current

Next generation initiation techniques

Science.gov (United States)

Warner, Tom; Derber, John; Zupanski, Milija; Cohn, Steve; Verlinde, Hans

1993-01-01

Four-dimensional data assimilation strategies can generally be classified as either current or next generation, depending upon whether they are used operationally or not. Current-generation data-assimilation techniques are those that are presently used routinely in operational-forecasting or research applications. They can be classified into the following categories: intermittent assimilation, Newtonian relaxation, and physical initialization. It should be noted that these techniques are the subject of continued research, and their improvement will parallel the development of next generation techniques described by the other speakers. Next generation assimilation techniques are those that are under development but are not yet used operationally. Most of these procedures are derived from control theory or variational methods and primarily represent continuous assimilation approaches, in which the data and model dynamics are 'fitted' to each other in an optimal way. Another 'next generation' category is the initialization of convective-scale models. Intermittent assimilation systems use an objective analysis to combine all observations within a time window that is centered on the analysis time. Continuous first-generation assimilation systems are usually based on the Newtonian-relaxation or 'nudging' techniques. Physical initialization procedures generally involve the use of standard or nonstandard data to force some physical process in the model during an assimilation period. Under the topic of next-generation assimilation techniques, variational approaches are currently being actively developed. Variational approaches seek to minimize a cost or penalty function which measures a model's fit to observations, background fields and other imposed constraints. Alternatively, the Kalman filter technique, which is also under investigation as a data assimilation procedure for numerical weather prediction, can yield acceptable initial conditions for mesoscale models. The

SIMULASI JARINGAN KOMPUTER MENGGUNAKAN CISCO PACKET TRACER

Directory of Open Access Journals (Sweden)

M Mufadhol

2012-01-01

Full Text Available Perkembangan jaringan komputer saat ini begitu pesat, monitoring jaringan komputer akan menjadi suatu hal yang sulit dan rumit. Koneksi jaringan komputer merupakan suatu hal yang mendasar dalam suatu jaringan, karena bila koneksi itu bermasalah maka semua jenis aplikasi yang dijalankan melalui jaringan komputer tidak dapat digunakan. Cisco packet tracer dapat digunakan untuk simulasi yang mencerminkan arsitektur dan juga model dari jaringan komputer pada sistem jaringan yang digunakan. Dengan menggunakan aplikasi cisco packet tracer, simulasi mengenai jaringan dapat dimanfaatkan menjadi informasi tentang keadaan koneksi komputer dalam suatu jaringan.

Next-Generation Sequencing of Tubal Intraepithelial Carcinomas.

Science.gov (United States)

McDaniel, Andrew S; Stall, Jennifer N; Hovelson, Daniel H; Cani, Andi K; Liu, Chia-Jen; Tomlins, Scott A; Cho, Kathleen R

2015-11-01

High-grade serous carcinoma (HGSC) is the most prevalent and lethal form of ovarian cancer. HGSCs frequently arise in the distal fallopian tubes rather than the ovary, developing from small precursor lesions called serous tubal intraepithelial carcinomas (TICs, or more specifically, STICs). While STICs have been reported to harbor TP53 mutations, detailed molecular characterizations of these lesions are lacking. We performed targeted next-generation sequencing (NGS) on formalin-fixed, paraffin-embedded tissue from 4 women, 2 with HGSC and 2 with uterine endometrioid carcinoma (UEC) who were diagnosed as having synchronous STICs. We detected concordant mutations in both HGSCs with synchronous STICs, including TP53 mutations as well as assumed germline BRCA1/2 alterations, confirming a clonal association between these lesions. Next-generation sequencing confirmed the presence of a STIC clonally unrelated to 1 case of UEC, and NGS of the other tubal lesion diagnosed as a STIC unexpectedly supported the lesion as a micrometastasis from the associated UEC. We demonstrate that targeted NGS can identify genetic alterations in minute lesions, such as TICs, and confirm TP53 mutations as early driving events for HGSC. Next-generation sequencing also demonstrated unexpected associations between presumed STICs and synchronous carcinomas, providing evidence that some TICs are actually metastases rather than HGSC precursors.

Genetic signs of multiple colonization events in Baltic ciscoes with radiation into sympatric spring- and autumn-spawners confined to early postglacial arrival.

Science.gov (United States)

Delling, Bo; Palm, Stefan; Palkopoulou, Eleftheria; Prestegaard, Tore

2014-11-01

Presence of sympatric populations may reflect local diversification or secondary contact of already distinct forms. The Baltic cisco (Coregonus albula) normally spawns in late autumn, but in a few lakes in Northern Europe sympatric autumn and spring- or winter-spawners have been described. So far, the evolutionary relationships and taxonomic status of these main life history forms have remained largely unclear. With microsatellites and mtDNA sequences, we analyzed extant and extinct spring- and autumn-spawners from a total of 23 Swedish localities, including sympatric populations. Published sequences from Baltic ciscoes in Germany and Finland, and Coregonus sardinella from North America were also included together with novel mtDNA sequences from Siberian C. sardinella. A clear genetic structure within Sweden was found that included two population assemblages markedly differentiated at microsatellites and apparently fixed for mtDNA haplotypes from two distinct clades. All sympatric Swedish populations belonged to the same assemblage, suggesting parallel evolution of spring-spawning rather than secondary contact. The pattern observed further suggests that postglacial immigration to Northern Europe occurred from at least two different refugia. Previous results showing that mtDNA in Baltic cisco is paraphyletic with respect to North American C. sardinella were confirmed. However, the inclusion of Siberian C. sardinella revealed a more complicated pattern, as these novel haplotypes were found within one of the two main C. albula clades and were clearly distinct from those in North American C. sardinella. The evolutionary history of Northern Hemisphere ciscoes thus seems to be more complex than previously recognized.

Biology and status of the shortnose cisco Coregonus reighardi Koelz in the Laurentian Great Lakes

Science.gov (United States)

Webb, Shane A.; Todd, Thomas N.

1995-01-01

The shortnose cisco, Coregonus reighardi, a member of the endemic species assemblage of Coregoninae in the Laurentian Great Lakes, was commercially important until overfishing and competition pressures from induced planktivores extirpated the species in Lakes Michigan and Ontario. Spawning shortnose ciscoes have been collected from Lake Huron and Georgian Bay of Lake Huron since 1956, however, no individuals have been collected from these habitats since 1985. Shortnose ciscoes were not collected during surveys of the cisco fishery of Georgian Bay during the summer of 1992 and spring of 1993. The lack of captures in the last eight years coupled with captures of only lone individuals in the last 16 years suggests the species may be extinct in all of the Laurentian system. The life history traits examined for Lake Huron shortnose ciscoes were similar to the conditions recorded for Lake Michigan and Ontario shortnose ciscoes, although Lake Huron fish were smaller.

The spatial scale for cisco recruitment dynamics in Lake Superior during 1978-2007

Science.gov (United States)

Rook, Benjamin J.; Hansen, Michael J.; Gorman, Owen T.

2012-01-01

The cisco Coregonus artedi was once the most abundant fish species in the Great Lakes, but currently cisco populations are greatly reduced and management agencies are attempting to restore the species throughout the basin. To increase understanding of the spatial scale at which density‐independent and density‐dependent factors influence cisco recruitment dynamics in the Great Lakes, we used a Ricker stock–recruitment model to identify and quantify the appropriate spatial scale for modeling age‐1 cisco recruitment dynamics in Lake Superior. We found that the recruitment variation of ciscoes in Lake Superior was best described by a five‐parameter regional model with separate stock–recruitment relationships for the western, southern, eastern, and northern regions. The spatial scale for modeling was about 260 km (range = 230–290 km). We also found that the density‐independent recruitment rate and the rate of compensatory density dependence varied among regions at different rates. The density‐independent recruitment rate was constant among regions (3.6 age‐1 recruits/spawner), whereas the rate of compensatory density dependence varied 16‐fold among regions (range = −0.2 to −2.9/spawner). Finally, we found that peak recruitment and the spawning stock size that produced peak recruitment varied among regions. Both peak recruitment (0.5–7.1 age‐1 recruits/ha) and the spawning stock size that produced peak recruitment (0.3–5.3 spawners/ha) varied 16‐fold among regions. Our findings support the hypothesis that the factors driving cisco recruitment operate within four different regions of Lake Superior, suggest that large‐scale abiotic factors are more important than small‐scale biotic factors in influencing cisco recruitment, and suggest that fishery managers throughout Lake Superior and the entire Great Lakes basin should address cisco restoration and management efforts on a regional scale in each lake.

Detection of planets in extremely weak central perturbation microlensing events via next-generation ground-based surveys

International Nuclear Information System (INIS)

Chung, Sun-Ju; Lee, Chung-Uk; Koo, Jae-Rim

2014-01-01

Even though the recently discovered high-magnification event MOA-2010-BLG-311 had complete coverage over its peak, confident planet detection did not happen due to extremely weak central perturbations (EWCPs, fractional deviations of ≲ 2%). For confident detection of planets in EWCP events, it is necessary to have both high cadence monitoring and high photometric accuracy better than those of current follow-up observation systems. The next-generation ground-based observation project, Korea Microlensing Telescope Network (KMTNet), satisfies these conditions. We estimate the probability of occurrence of EWCP events with fractional deviations of ≤2% in high-magnification events and the efficiency of detecting planets in the EWCP events using the KMTNet. From this study, we find that the EWCP events occur with a frequency of >50% in the case of ≲ 100 M E planets with separations of 0.2 AU ≲ d ≲ 20 AU. We find that for main-sequence and sub-giant source stars, ≳ 1 M E planets in EWCP events with deviations ≤2% can be detected with frequency >50% in a certain range that changes with the planet mass. However, it is difficult to detect planets in EWCP events of bright stars like giant stars because it is easy for KMTNet to be saturated around the peak of the events because of its constant exposure time. EWCP events are caused by close, intermediate, and wide planetary systems with low-mass planets and close and wide planetary systems with massive planets. Therefore, we expect that a much greater variety of planetary systems than those already detected, which are mostly intermediate planetary systems, regardless of the planet mass, will be significantly detected in the near future.

Safety design philosophy of the ABWR for the next generation LWRs

International Nuclear Information System (INIS)

Sato, Takashi; Akinaga, Makoto; Kojima, Yoshihiro

2009-01-01

The paper presents safety design philosophy of the advanced boiling water reactor (ABWR) to be reflected in developing the next generation light water reactors (LWRs). The basic policy of the ABWR safety design was to improve safety and reduce cost simultaneously by reflecting lessons learned of precursors, incidents and accidents that were beyond the design basis such as the Three Mile Island Unit 2 (TMI 2) accident. The ABWR is a fully active safety plant. The ABWR enhanced redundancy and diversity of active safety systems using probabilistic safety assessment (PSA) insights. It adopted a complete three division active emergency core cooling system (ECCS) and attained a very low core damage frequency (CDF) value of less than 10 -7 /ry for internal events. Only very small residual risks, if any, rather exist in external events such as an extremely large earthquake beyond the design basis. This is because external events can constitute a common cause that disables all the redundant active safety systems. Therefore, it is useless to add one more ECCS train and make a four division active ECCS for external events. Nowadays, however, fully passive safety LWRs are already established. Incorporating some of these passive safety systems we can also establish the next generation LWRs that are truly strong against external events. We can establish a plant that can survive a giant earthquake at least three days without AC power source, SA proof safety design that enables no containment failure and no evacuation to eliminate the residual risks. The same basic policy as the ABWR to improve safety and reduce cost simultaneously is again effective for the next generation LWRs. (author)

Diversity in shortjaw cisco (Coregonus zenithicus) in North America

Science.gov (United States)

Todd, T.N.; Steinhilber, M.

2002-01-01

Shortjaw cisco (Coregonus zenithicus) exhibit morphological variability across their geographic range in North America and could comprise more than one distinct morph or taxon. To investigate this, principal components analysis was applied to a data set that consisted of four variables from nine localities. All data were obtained from digital images of the specimens and the excised first gill arch. Confidence ellipses (95%) about the means of bivariate distributions of the principal components revealed that some populations were distinct from the others, but a continuity of overlap clouded understanding of pattern among the variation. Most populations had more and longer gillrakers than shortjaw cisco from George Lake (Manitoba) and Basswood Lake (Ontario) that had fewer and shorter gillrakers. This analysis supports the existence of a short- and few-rakered morph and a long- and many-rakered morph. However, most populations of shortjaw cisco from the Great Lakes across Canada to the Arctic share a similar morphology and likely represent a single, widespread species.

General-purpose event generators for LHC physics

CERN Document Server

Buckley, Andy; Gieseke, Stefan; Grellscheid, David; Hoche, Stefan; Hoeth, Hendrik; Krauss, Frank; Lonnblad, Leif; Nurse, Emily; Richardson, Peter; Schumann, Steffen; Seymour, Michael H.; Sjostrand, Torbjorn; Skands, Peter; Webber, Bryan

2011-01-01

We review the physics basis, main features and use of general-purpose Monte Carlo event generators for the simulation of proton-proton collisions at the Large Hadron Collider. Topics included are: the generation of hard-scattering matrix elements for processes of interest, at both leading and next-to-leading QCD perturbative order; their matching to approximate treatments of higher orders based on the showering approximation; the parton and dipole shower formulations; parton distribution functions for event generators; non-perturbative aspects such as soft QCD collisions, the underlying event and diffractive processes; the string and cluster models for hadron formation; the treatment of hadron and tau decays; the inclusion of QED radiation and beyond-Standard-Model processes. We describe the principal features of the ARIADNE, Herwig++, PYTHIA 8 and SHERPA generators, together with the Rivet and Professor validation and tuning tools, and discuss the physics philosophy behind the proper use of these generators ...

Next generation light water reactors

International Nuclear Information System (INIS)

Omoto, Akira

1992-01-01

In the countries where the new order of nuclear reactors has ceased, the development of the light water reactors of new type has been discussed, aiming at the revival of nuclear power. Also in Japan, since it is expected that light water reactors continue to be the main power reactor for long period, the technology of light water reactors of next generation has been discussed. For the development of nuclear power, extremely long lead time is required. The light water reactors of next generation now in consideration will continue to be operated till the middle of the next century, therefore, they must take in advance sufficiently the needs of the age. The improvement of the way men and the facilities should be, the simple design, the flexibility to the trend of fuel cycle and so on are required for the light water reactors of next generation. The trend of the development of next generation light water reactors is discussed. The construction of an ABWR was started in September, 1991, as No. 6 plant in Kashiwazaki Kariwa Power Station. (K.I.)

Guide to Cisco Routers Configuration Becoming a Router Geek

CERN Document Server

Alani, Mohammed M

2012-01-01

This work provides a guide to the configuration of Cisco routers, from tasks for beginners to advanced operations. A collection of detailed "how-to" instructions are presented, which will be of use to all professionals and students who engage with Cisco routers in the field or in the lab. The guide starts with the simple step-by-step task of connecting the router and performing basic configuration, before building up to complex and sensitive operations such as router IOS upgrade and Site-to-Site VPNs.

IPv6 and IPsec Tests of a Space-Based Asset, the Cisco Router in Low Earth Orbit (CLEO)

Science.gov (United States)

Ivancic, William; Stewart, David; Wood, Lloyd; Jackson, Chris; Northam, James; Wilhelm, James

2008-01-01

This report documents the design of network infrastructure to support testing and demonstrating network-centric operations and command and control of space-based assets, using IPv6 and IPsec. These tests were performed using the Cisco router in Low Earth Orbit (CLEO), an experimental payload onboard the United Kingdom--Disaster Monitoring Constellation (UK-DMC) satellite built and operated by Surrey Satellite Technology Ltd (SSTL). On Thursday, 29 March 2007, NASA Glenn Research Center, Cisco Systems and SSTL performed the first configuration and demonstration of IPsec and IPv6 onboard a satellite in low Earth orbit. IPv6 is the next generation of the Internet Protocol (IP), designed to improve on the popular IPv4 that built the Internet, while IPsec is the protocol used to secure communication across IP networks. This demonstration was made possible in part by NASA s Earth Science Technology Office (ESTO) and shows that new commercial technologies such as mobile networking, IPv6 and IPsec can be used for commercial, military and government space applications. This has direct application to NASA s Vision for Space Exploration. The success of CLEO has paved the way for new spacebased Internet technologies, such as the planned Internet Routing In Space (IRIS) payload at geostationary orbit, which will be a U.S. Department of Defense Joint Capability Technology Demonstration. This is a sanitized report for public distribution. All real addressing has been changed to psueco addressing.

Exploitation dynamics of small fish stocks like Arctic cisco

Science.gov (United States)

Nielsen, Jennifer L.

2004-01-01

Potential impacts to the Arctic cisco population fall into both demographic and behavioral categories. Possible demographic impacts include stock recruitment effects, limited escapement into marine habitats, and variable age-class reproductive success. Potential behavioral impacts involve migratory patterns, variable life histories, and strategies for seasonal feeding. Arctic cisco stocks are highly susceptible to over-exploitation due to our limited basic knowledge of the highly variable Arctic environment and the role they play in this dynamic ecosystem.Our knowledge of potential demographic changes is very limited, and it is necessary to determine the abundance and recruitment of the hypothesized Mackenzie River source population, the extent of the coastal migratory corridor, growth patterns, and coastal upwelling and mixing effects on population dynamics for this species. Information needed to answer some of the demographic questions includes basic evolutionary history and molecular genetics of Arctic cisco (for instance, are there contributions to the Arctic cisco stock from the Yukon?), what is the effective population size (i.e., breeding population size), and potential links to changes in climate. The basic behavioral questions include migratory and variable life history questions. For instance, the extent of movement back and forth between freshwater and the sea, age-specific differences in food web dynamics, and nearshore brackish and high salinity habitats are topics that should be studied. Life history data should be gathered to understand the variation in age at reproduction, salinity tolerance, scale and duration of the freshwater stage, survival, and adult migration. Both molecular and ecological tools should be integrated to manage the Arctic cisco stock(s), such as understanding global climate changes on patterns of harvest and recruitment, and the genetics of population structure and colonization. Perhaps other populations are contributing to the

General-purpose event generators for LHC physics

International Nuclear Information System (INIS)

Buckley, Andy; Butterworth, Jonathan; Gieseke, Stefan; Grellscheid, David; Hoeche, Stefan; Hoeth, Hendrik; Krauss, Frank; Loennblad, Leif; Nurse, Emily; Richardson, Peter; Schumann, Steffen; Seymour, Michael H.; Sjoestrand, Torbjoern; Skands, Peter; Webber, Bryan

2011-01-01

We review the physics basis, main features and use of general-purpose Monte Carlo event generators for the simulation of proton-proton collisions at the Large Hadron Collider. Topics included are: the generation of hard scattering matrix elements for processes of interest, at both leading and next-to-leading QCD perturbative order; their matching to approximate treatments of higher orders based on the showering approximation; the parton and dipole shower formulations; parton distribution functions for event generators; non-perturbative aspects such as soft QCD collisions, the underlying event and diffractive processes; the string and cluster models for hadron formation; the treatment of hadron and tau decays; the inclusion of QED radiation and beyond Standard Model processes. We describe the principal features of the ARIADNE, Herwig++, PYTHIA 8 and SHERPA generators, together with the Rivet and Professor validation and tuning tools, and discuss the physics philosophy behind the proper use of these generators and tools. This review is aimed at phenomenologists wishing to understand better how parton-level predictions are translated into hadron-level events as well as experimentalists seeking a deeper insight into the tools available for signal and background simulation at the LHC.

General-purpose event generators for LHC physics

Energy Technology Data Exchange (ETDEWEB)

Buckley, Andy [PPE Group, School of Physics and Astronomy, University of Edinburgh, EH25 9PN (United Kingdom); Butterworth, Jonathan [Department of Physics and Astronomy, University College London, WC1E 6BT (United Kingdom); Gieseke, Stefan [Institute for Theoretical Physics, Karlsruhe Institute of Technology, D-76128 Karlsruhe (Germany); Grellscheid, David [Institute for Particle Physics Phenomenology, Durham University, DH1 3LE (United Kingdom); Hoeche, Stefan [SLAC National Accelerator Laboratory, Menlo Park, CA 94025 (United States); Hoeth, Hendrik; Krauss, Frank [Institute for Particle Physics Phenomenology, Durham University, DH1 3LE (United Kingdom); Loennblad, Leif [Department of Astronomy and Theoretical Physics, Lund University (Sweden); PH Department, TH Unit, CERN, CH-1211 Geneva 23 (Switzerland); Nurse, Emily [Department of Physics and Astronomy, University College London, WC1E 6BT (United Kingdom); Richardson, Peter [Institute for Particle Physics Phenomenology, Durham University, DH1 3LE (United Kingdom); Schumann, Steffen [Institute for Theoretical Physics, University of Heidelberg, 69120 Heidelberg (Germany); Seymour, Michael H. [School of Physics and Astronomy, University of Manchester, M13 9PL (United Kingdom); Sjoestrand, Torbjoern [Department of Astronomy and Theoretical Physics, Lund University (Sweden); Skands, Peter [PH Department, TH Unit, CERN, CH-1211 Geneva 23 (Switzerland); Webber, Bryan, E-mail: webber@hep.phy.cam.ac.uk [Cavendish Laboratory, J.J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom)

2011-07-15

We review the physics basis, main features and use of general-purpose Monte Carlo event generators for the simulation of proton-proton collisions at the Large Hadron Collider. Topics included are: the generation of hard scattering matrix elements for processes of interest, at both leading and next-to-leading QCD perturbative order; their matching to approximate treatments of higher orders based on the showering approximation; the parton and dipole shower formulations; parton distribution functions for event generators; non-perturbative aspects such as soft QCD collisions, the underlying event and diffractive processes; the string and cluster models for hadron formation; the treatment of hadron and tau decays; the inclusion of QED radiation and beyond Standard Model processes. We describe the principal features of the ARIADNE, Herwig++, PYTHIA 8 and SHERPA generators, together with the Rivet and Professor validation and tuning tools, and discuss the physics philosophy behind the proper use of these generators and tools. This review is aimed at phenomenologists wishing to understand better how parton-level predictions are translated into hadron-level events as well as experimentalists seeking a deeper insight into the tools available for signal and background simulation at the LHC.

General-purpose event generators for LHC physics

Energy Technology Data Exchange (ETDEWEB)

Buckley, Andy; /Edinburgh U.; Butterworth, Jonathan; /University Coll. London; Gieseke, Stefan; /Karlsruhe U., ITP; Grellscheid, David; /Durham U., IPPP; Hoche, Stefan; /SLAC; Hoeth, Hendrik; Krauss, Frank; /Durham U., IPPP; Lonnblad, Leif; /Lund U., Dept. Theor. Phys. /CERN; Nurse, Emily; /University Coll. London; Richardson, Peter; /Durham U., IPPP; Schumann, Steffen; /Heidelberg U.; Seymour, Michael H.; /Manchester U.; Sjostrand, Torbjorn; /Lund U., Dept. Theor. Phys.; Skands, Peter; /CERN; Webber, Bryan; /Cambridge U.

2011-03-03

We review the physics basis, main features and use of general-purpose Monte Carlo event generators for the simulation of proton-proton collisions at the Large Hadron Collider. Topics included are: the generation of hard-scattering matrix elements for processes of interest, at both leading and next-to-leading QCD perturbative order; their matching to approximate treatments of higher orders based on the showering approximation; the parton and dipole shower formulations; parton distribution functions for event generators; non-perturbative aspects such as soft QCD collisions, the underlying event and diffractive processes; the string and cluster models for hadron formation; the treatment of hadron and tau decays; the inclusion of QED radiation and beyond-Standard-Model processes. We describe the principal features of the Ariadne, Herwig++, Pythia 8 and Sherpa generators, together with the Rivet and Professor validation and tuning tools, and discuss the physics philosophy behind the proper use of these generators and tools. This review is aimed at phenomenologists wishing to understand better how parton-level predictions are translated into hadron-level events as well as experimentalists wanting a deeper insight into the tools available for signal and background simulation at the LHC.

2009 Spawning cisco investigations in the Canadian waters of Lake Superior

Science.gov (United States)

Yule, Daniel L.; Cholwek, Gary A.; Evrard, Lori M.; E. Berglund,; K.I. Cullis,

2010-01-01

We sampled with acoustics (AC) and midwater trawls (MT) to determine cisco abundance in Lake Superior’s Thunder and Black bays during 8-14 November, 2009. Total abundance of spawning-size (≥ 250 mm total length) ciscoes was estimated at 6.25 million in Thunder Bay and 1.12 million in Black Bay. Exploitation fractions of market-size (≥ age 6) females from Thunder and Black bays for 2009 were estimated at 7.1% and 11.3%, respectively; below the recommended maximum annual harvest of 15% recently adopted by Lake Superior fisheries managers. Given Thunder Bay spawner densities are on a downward trajectory, and recruitment since the 2003 year-class has been low, it is likely the exploitation fractions will increase in the future. After 2010, the Ontario Ministry of Natural Resources (OMNR) will carry on the AC program as a management activity. It is likely suspended experimental gill net (GN) samples will be used to ground truth future AC samples. In 2009, we characterized the length and age structure of Thunder Bay ciscoes using both MT samples and GN samples. Females represented 49% of the MT catch, but only 39% in GN samples. Catching a smaller proportion of females in GN samples resulted in a lower female population estimate and a higher estimated exploitation fraction (10.4%) compared to MT samples (7.1%). Experimental gill net effort was limited to 10-11.8 m water column depths where midwater trawl samples also caught roughly 40% females. Ciscoes ≥ age 17 (≥ 1992 year class) were common in Black Bay, but rare in Thunder Bay suggesting: 1) the stocks may be distinct; and 2) total mortality of ciscoes returning to spawn in Black Bay in recent years has been lower than ciscoes returning to Thunder Bay. Our mid-November 2009 effort to assess the Black Bay stock by sampling outside of the 3 bay in the lake proper was deemed successful, but this should be confirmed by sampling the Black Bay region during both mid- and late-November 2010.

Reassessment of the predatory effects of rainbow smelt on ciscoes in Lake Superior

Science.gov (United States)

Myers, Jared T.; Jones, Michael L.; Stockwell, Jason D.; Yule, Daniel L.

2009-01-01

Evidence from small lakes suggests that predation on larval ciscoes Coregonus artedi by nonnative rainbow smelt Osmerus mordax can lead to cisco suppression or extirpation. However, evidence from larger lakes has led to equivocal conclusions. In this study, we examine the potential predation effects of rainbow smelt in two adjacent but contrasting embayments in Lake Superior (Thunder and Black bays, Ontario). During May 2006, we sampled the ichthyoplankton, pelagic fish communities, and diet composition of rainbow smelt in both bays. Using acoustics and midwater trawling, we estimated rainbow smelt densities to be 476 ± 34/ha (mean ± SE) in Thunder Bay and 3,435 ± 460/ha in Black Bay. We used a bioenergetics model to estimate the proportion of cisco larvae consumed by rainbow smelt. Our results suggest that predation by rainbow smelt accounts for 15–52% and 37–100% of the mortality of larval ciscoes in Thunder and Black bays, respectively, depending on the predator feeding rate and the scale of predator–prey overlap. We also examined the sensitivity of past conclusions (based on 1974 field collections) to assumptions of temporal overlap between rainbow smelt and larval ciscoes and estimates of rainbow smelt abundance derived from bottom trawl samples. After adjusting these parameters to reflect current understanding, we found that the previous predation estimates may have been conservative. We conclude that rainbow smelt may have been a more important contributor to the demise and slow recovery of ciscoes in Lake Superior than previously thought.

[Differential expression of DTSsa4 Tc1-like transposons in closely related populations of Baikal ciscoes].

Science.gov (United States)

Bychenko, O S; Sukhanova, L V; Azhikina, T L; Sverdlov, E D

2009-01-01

Two representatives of Baikal ciscoes - lake cisco and omul - diverged from a common ancestor as recently as 10-20 thousand years ago. We have found an increasing expression level of DTSsa4 Tc1-like DNA transposons in cisco and omul brains. The mapping of the sequences of these transposons from Salmo salar and Danio rerio genomes has shown that in some cases, these transposons are located in the 5' and 3' regions, as well as in the promoter regions of various genes. Probably, Tc1-like transposons affect the activity of neighboring genes, providing the adaptive divergence of the cisco population.

Allelic variability in species and stocks of Lake Superior ciscoes (Coregoninae)

Science.gov (United States)

Todd, Thomas N.

1981-01-01

Starch gel electrophoresis was used as a means of recognizing species and stocks in Lake Superior Coregonus. Allelic variability at isocitrate dehydrogenase and glycerol-3-phosphate dehydrogenase loci was recorded for samples of lake herring (Coregonus artedii), bloater (C. hoyi), kiyi (C. kiyi), and shortjaw cisco (C. zenithicus) from five Lake Superior localities. The observed frequencies of genotypes within each subsample did not differ significantly from those expected on the basis of random mating, and suggested that each subsample represented either a random sample from a larger randomly mating population or an independent and isolated subpopulation within which mating was random. Significant contingency X2 values for comparisons between both localities and species suggested that more than one randomly mating population occurred among the Lake Superior ciscoes, but did not reveal how many such populations there were. In contrast to the genetic results of this study, morphology seems to be a better descriptor of cisco stocks, and identification of cisco stocks and species will still have to be based on morphological criteria until more data are forthcoming. Where several species are sympatric, management should strive to preserve the least abundant. Failure to do so could result in the extinction or depletion of the rarer forms.

Generation Next

Science.gov (United States)

Hawkins, B. Denise

2010-01-01

There is a shortage of accounting professors with Ph.D.s who can prepare the next generation. To help reverse the faculty deficit, the American Institute of Certified Public Accountants (CPAs) has created the new Accounting Doctoral Scholars program by pooling more than $17 million and soliciting commitments from more than 70 of the nation's…

Evidence for migratory spawning behavior by morphologically distinct Cisco (Coregonus artedi) from a small inland lake

Science.gov (United States)

Ross, Alexander J.; Weidel, Brian C.; Leneker, Mellisa; Solomon, Christopher T.

2017-01-01

Conservation and management of rare fishes relies on managers having the most informed understanding of the underlying ecology of the species under investigation. Cisco (Coregonus artedi), a species of conservation concern, is a cold-water pelagic fish that is notoriously variable in morphometry and life history. Published reports indicate, at spawning time, Cisco in great lakes may migrate into or through large rivers, whereas those in small lakes move inshore. Nonetheless, during a sampling trip to Follensby Pond, a 393 ha lake in the Adirondack Mountains, New York, we observed gravid Cisco swimming over an outlet sill from a narrow shallow stream and into the lake. We opportunistically dip-netted a small subsample of 11 individuals entering the lake from the stream (three female, eight male) and compared them to fish captured between 2013 and 2015 with gillnets in the lake. Stream-captured Cisco were considerably larger than lake-captured individuals at a given age, had significantly larger asymptotic length, and were present only as mature individuals between age of 3 and age 5. These results could suggest either Cisco are migrating from a nearby lake to spawn in Follensby Pond, or that a distinct morphotype of Cisco from Follensby Pond migrates out to the stream and then back in at spawning time. Our results appear to complement a handful of other cases in which Cisco spawning migrations have been documented and to provide the first evidence for such behavior in a small inland lake.

Spawning Cisco investigations in Canada waters of Lake Superior during 2007

Science.gov (United States)

Yule, Daniel L.; Evrard, Lori M.; Cholwek, Gary A.; Addison, Peter A.; Cullis, Ken I.

2008-01-01

Cisco Coregonus artedi form pre-spawning aggregations in Lake Superior during November with the bulk of spawning occurring during late November through early December (Dryer and Beil 1964). Eggs are broadcast into open water (Smith 1956) with fertilized eggs settling to the lakebed (Dryer and Beil 1964). Peak hatching occurs the following May (United States Geological Survey – Great Lakes Science Center, GLSC, unpublished data). Interannual variability in year class strength is high, but tends to be synchronous across different regions of Lake Superior (Bronte et al. 2003). November 2005 sampling of Thunder Bay showed 14 year-classes were present with the oldest fish being from the 1984 year-class (Yule et al. 2008). The ciscoes sampled were predominantly from five year classes that hatched during 1988, 1989, 1990, 1998, and 2003. These same strong year-classes were found in the western arm of Lake Superior during November 2006 (GLSC, unpublished data). Growth is rapid in the first few years of life with minimal growth after age-8 (Yule et al. 2008). Ciscoes exceeding 250 mm total length (TL) are typically sexually mature (Yule et al. 2006b, 2008). Thunder Bay ciscoes have high annual survival with rates for females and males averaging 0.80 and 0.75, respectively; females have higher rates of fishing-induced mortality compared to males but lower rates of natural mortality (Yule et al. 2008). Some Lake Superior stocks are currently commercially fished with the bulk of harvest occurring during November when fishers target females for their roe. The bulk of fish are harvested from Thunder Bay using suspended gillnets with mesh sizes ranging from 79-89 mm stretch measure. Ciscoes younger then age-5 make up a very small proportion (<0.1%) of the harvest (Yule, et al. 2008).

Next Generation Microshutter Arrays Project

Data.gov (United States)

National Aeronautics and Space Administration — We propose to develop the next generation MicroShutter Array (MSA) as a multi-object field selector for missions anticipated in the next two decades. For many...

Project control - the next generation

International Nuclear Information System (INIS)

Iorii, V.F.; McKinnon, B.L.

1993-01-01

The Yucca Mountain Site Characterization Project (YMP) is the U.S. Department of Energy's (DOE) second largest Major System Acquisition Project. We have developed an integrated planning and control system (called PACS) that we believe represents the 'Next Generation' in project control. PACS integrates technical scope, cost, and schedule information for over 50 participating organizations and produces performances measurement reports for science and engineering managers at all levels. Our 'Next Generation' project control too, PACS, has been found to be in compliance with the new DOE Project Control System Guidelines. Additionally, the nuclear utility oversight group of the Edison Electric Institute has suggested PACS be used as a model for other civilian radioactive waste management projects. A 'Next Generation' project control tool will be necessary to do science in the 21st century

[Dynamics of parasite communities in an age series of Arctic Cisco Coregonus migratorius (Georgi, 1775)].

Science.gov (United States)

Dugarov, Zh N; Pronin, N M

2013-01-01

Parasite communities of Arctic cisco from Chivyrkui Bay of Lake Baikal have been analyzed at levels of a host individual (infracommunity), a individual age group of a host-(assemblages of infracommunities), and a host population (component community). Significant positive correlations of parameters of species richness (number of parasite species, Margalef and Menhinick indices) with the age of Arctic cisco were recorded only at the level of parasite inffacommunities. The absence of linear positive correlations between the parameters of species richness and the age of Arctic cisco at the level of assemblages of parasite infracommunities were revealed for the first time for fish of Lake Baikal. The peculiarity of the dynamics of parasite communities of. Arctic cisco is determined by specific features of the host physiology and ecology, primarily by the age dynamics of the feeding spectrum.

Mission E-Possible: The Cisco E-Learning Story.

Science.gov (United States)

Galagan, Patricia A.

2001-01-01

Describes the electronic learning program prescribed by Cisco director John Chambers. To respond to his challenge that the program would have to be exemplary and serve thousands, stakeholders integrated the company's e-learning initiatives. (JOW)

Update COSEWIC status report on the shortjaw cisco, Coregonus zenithicus, in Canada

Science.gov (United States)

Todd, Thomas N.

2003-01-01

Extirpated in most of the Great Lakes, the shortjaw cisco, Coregonus zenithicus, is currently found in Lakes Superior and Nipigon in addition to at least 22 Canadian lakes. The species exhibits morphological and genetic variability throughout its range and may consist of more than one distinct taxon. However, a common morph is widely distributed from the Great Lakes to the Northwest Territories, consistent with a hypothesis of preglacial origin for the species. Shortjaw ciscoes have declined because of excessive exploitation by food fisheries, habitat degradation, and predation and competition with introduced and exotic species such as alewife, Alosa pseudoharengus, and rainbow smelt, Osmerus mordax. The status of the species in most Canadian lakes is unknown, but continuing declines in those lakes that have been monitored suggest that the shortjaw cisco should be considered as threatened throughout its range.

Unweighted event generation in hadronic WZ production at order $(\\alpha_{S})$

CERN Document Server

Dobbs, Matt; Lefebvre, Michel

2001-01-01

We present an algorithm for unweighted event generation in the partonic process pp -> WZ (j) with leptonic decays at next-to-leading order in alpha_S. Monte Carlo programs for processes such as this frequently generate events with negative weights in certain regions of phase space. For simulations of experimental data one would like to have unweighted events only. We demonstrate how the phase space from the matrix elements can be combined to achieve unweighted event generation using a second stage Monte Carlo integration over a volume of real emissions (jets). Observable quantities are kept fixed in the laboratory frame throughout the integration. The algorithm is applicable to a broader class of processes and is CPU intensive.

Next-Generation Tools For Next-Generation Surveys

Science.gov (United States)

Murray, S. G.

2017-04-01

The next generation of large-scale galaxy surveys, across the electromagnetic spectrum, loom on the horizon as explosively game-changing datasets, in terms of our understanding of cosmology and structure formation. We are on the brink of a torrent of data that is set to both confirm and constrain current theories to an unprecedented level, and potentially overturn many of our conceptions. One of the great challenges of this forthcoming deluge is to extract maximal scientific content from the vast array of raw data. This challenge requires not only well-understood and robust physical models, but a commensurate network of software implementations with which to efficiently apply them. The halo model, a semi-analytic treatment of cosmological spatial statistics down to nonlinear scales, provides an excellent mathematical framework for exploring the nature of dark matter. This thesis presents a next-generation toolkit based on the halo model formalism, intended to fulfil the requirements of next-generation surveys. Our toolkit comprises three tools: (i) hmf, a comprehensive and flexible calculator for halo mass functions (HMFs) within extended Press-Schechter theory, (ii) the MRP distribution for extremely efficient analytic characterisation of HMFs, and (iii) halomod, an extension of hmf which provides support for the full range of halo model components. In addition to the development and technical presentation of these tools, we apply each to the task of physical modelling. With hmf, we determine the precision of our knowledge of the HMF, due to uncertainty in our knowledge of the cosmological parameters, over the past decade of cosmic microwave background (CMB) experiments. We place rule-of-thumb uncertainties on the predicted HMF for the Planck cosmology, and find that current limits on the precision are driven by modeling uncertainties rather than those from cosmological parameters. With the MRP, we create and test a method for robustly fitting the HMF to observed

Dynalight Next Generation

DEFF Research Database (Denmark)

Jørgensen, Bo Nørregaard; Ottosen, Carl-Otto; Dam-Hansen, Carsten

2016-01-01

The project aims to develop the next generation of energy cost-efficient artificial lighting control that enables greenhouse growers to adapt their use of artificial lighting dynamically to fluctuations in the price of electricity. This is a necessity as fluctuations in the price of electricity c...

NASA's Next Generation Space Geodesy Program

Science.gov (United States)

Merkowitz, S. M.; Desai, S. D.; Gross, R. S.; Hillard, L. M.; Lemoine, F. G.; Long, J. L.; Ma, C.; McGarry, J. F.; Murphy, D.; Noll, C. E.;

Generation 'Next' and nuclear power

International Nuclear Information System (INIS)

Sergeev, A.A.

2001-01-01

My generation was labeled by Russian mass media as generation 'Next.' My technical education is above average. My current position is as a mechanical engineer in the leading research and development institute for Russian nuclear engineering for peaceful applications. It is noteworthy to point out that many of our developments were really first-of-a-kind in the history of engineering. However, it is difficult to grasp the importance of these accomplishments, especially since the progress of nuclear technologies is at a standstill. Can generation 'Next' be independent in their attitude towards nuclear power or shall we rely on the opinions of elder colleagues in our industry? (authors)

Next-to-next-leading order correction to 3-jet rate and event-shape ...

Indian Academy of Sciences (India)

The coupling constant, , was measured by two different methods: first by employing the three-jet observables. Combining all the data, the value of as at next-to-next leading order (NNLO) was determined to be 0.117 ± 0.004(hard) ± 0.006(theo). Secondly, from the event-shape distributions, the strong coupling constant, ...

78 FR 73109 - Radio Broadcasting Services; Benjamin and Cisco, TX; De Beque, CO; Port Lions, AK; Rule and...

Science.gov (United States)

2013-12-05

... Broadcasting Services; Benjamin and Cisco, TX; De Beque, CO; Port Lions, AK; Rule and Shamrock, TX AGENCY... 237C3 at Benjamin, Texas; Channel 261C3 at Cisco, Texas; Channel 288C2 at Rule, Texas; and Channel 225C2..., Channel 237C3; by removing Cisco, Channel 261C3; by removing Channel 288C2 at Rule; and by removing...

The Next Great Generation?

Science.gov (United States)

Brownstein, Andrew

2000-01-01

Discusses ideas from a new book, "Millennials Rising: The Next Great Generation," (by Neil Howe and William Strauss) suggesting that youth culture is on the cusp of a radical shift with the generation beginning with this year's college freshmen who are typically team oriented, optimistic, and poised for greatness on a global scale. Includes a…

Development of technology for next generation reactor - Development of next generation reactor in Korea -

Energy Technology Data Exchange (ETDEWEB)

Park, Jong Kyun; Chang, Moon Heuy; Hwang, Yung Dong [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of); and others

1993-09-01

The project, development of next generation reactor, aims overall related technology development and obtainment of related license in 2001. The development direction is to determine the reactor type and to build up the design concept in 1994. For development trend analysis of foreign next generation reactor, level-1 PSA, fuel cycle analysis and computer code development are performed on System 80+ and AP 600. Especially for design characteristics analysis and volume upgrade of AP 600, nuclear fuel and reactor core design analysis, coolant circuit design analysis, mechanical structure design analysis and safety analysis etc. are performed. (Author).

Tailoring next-generation biofuels and their combustion in next-generation engines

Energy Technology Data Exchange (ETDEWEB)

Gladden, John Michael [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Wu, Weihua [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Taatjes, Craig A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Scheer, Adam Michael [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Turner, Kevin M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Yu, Eizadora T. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); O' Bryan, Greg [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Powell, Amy Jo [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gao, Connie W. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

2013-11-01

Increasing energy costs, the dependence on foreign oil supplies, and environmental concerns have emphasized the need to produce sustainable renewable fuels and chemicals. The strategy for producing next-generation biofuels must include efficient processes for biomass conversion to liquid fuels and the fuels must be compatible with current and future engines. Unfortunately, biofuel development generally takes place without any consideration of combustion characteristics, and combustion scientists typically measure biofuels properties without any feedback to the production design. We seek to optimize the fuel/engine system by bringing combustion performance, specifically for advanced next-generation engines, into the development of novel biosynthetic fuel pathways. Here we report an innovative coupling of combustion chemistry, from fundamentals to engine measurements, to the optimization of fuel production using metabolic engineering. We have established the necessary connections among the fundamental chemistry, engine science, and synthetic biology for fuel production, building a powerful framework for co-development of engines and biofuels.

Arctic Cisco, Coregonus autumnalis, distribution, migration and spawning in the Mackenzie River

International Nuclear Information System (INIS)

Dillinger, R.E. Jr.; Birt, T.P.; Green, J.M.

1992-01-01

Oil exploration along the Beaufort Sea coast of North America has raised interest in populations of Arctic Cisco. A synopsis is presented of research on Arctic Cisco distributions and spawning activities in the Mackenzie River system. The distribution, migration, and spawning activities of Arctic Cisco in the tributaries of the Mackenzie River system were found to be more extensive than previously reported. The Peel River population had the earliest migration time, mid-July; however, a small movement of mature males upriver also occurred there in mid-September. Major movements of mature males and females took place in both late July and early to mid-Spetember in the Arctic Red River. Migrations in the other river systems occurred in late August and early September. Arctic Ciscoes in the only river south of Great Bear Lake that has been found to contain this species, the Liard River, may show a mixed life history strategy. The apparently long distance the fish must swim, the lack of any known populations in any of the rivers between the Liard and the Great Bear rivers, and the lack of evidence of migrations past Fort Simpson suggest that this population may contain non-anadromous forms. No actual spawning was seen in any of the populations, but possible areas were noted, one in the Peel River and one in the Liard River. 18 refs., 3 figs., 2 tabs

Orchestra of Change: Strategically Harmonizing National Character, Military Forces, and the Character of War

Science.gov (United States)

2015-06-01

adversaries use chat rooms, mobile devices, and 1 Miniwatts Marketing Group, “Internet World Stats...Internet World Stats, February 27, 2015, http://www.internetworldstats.com/stats.htm. 2 “ Cisco Visual Networking Index: Forecast and Methodology...2013–2018,” Cisco , accessed February 26, 2015, http://cisco.com/c/en/us/solutions/collateral/service- provider/ip-ngn-ip-next-generation-network

Males exceed females in PCB concentrations of cisco (Coregonus artedi) from Lake Superior

Science.gov (United States)

Madenjian, Charles P.; Yule, Daniel L.; Chernyak, Sergei M.; Begnoche, Linda J.; Berglund, Eric K.; Isaac, Edmund J.

2014-01-01

We determined whole-fish polychlorinated biphenyl (PCB) concentrations of 25 male and 25 female age-7 ciscoes (Coregonus artedi) captured from a spawning aggregation in Thunder Bay, Lake Superior, during November 2010. We also determined PCB concentrations in the ovaries and somatic tissue of five additional female ciscoes (ages 5–22). All 55 of these ciscoes were in ripe or nearly ripe condition. Bioenergetics modeling was used to determine the contribution of the growth dilution effect toward a difference in PCB concentrations between the sexes, as females grew substantially faster than males. Results showed that the PCB concentration of males (mean = 141 ng/g) was 43% greater than that of females (mean = 98 ng/g), and this difference was highly significant (P ovaries and the somatic tissue of the five females were 135 and 100 ng/g, respectively. Based on these PCB determinations for the ovaries and somatic tissue, we concluded that release of eggs by females at previous spawnings was not a contributing factor to the observed difference in PCB concentrations between the sexes. Bioenergetics modeling results indicated that the growth dilution effect could explain males being higher than females in PCB concentration by only 3–7%. We concluded that the higher PCB concentration in males was most likely due to higher rate of energy expenditure, originating from greater activity and a higher resting metabolic rate. Mean PCB concentration in the cisco eggs was well below the U. S. Food and Drug Administration and Ontario Ministry of Environment guidelines of 2000 and 844 ng/g, respectively, and this finding may have implications for the cisco roe fishery currently operating in Lake Superior.

Cluster cosmology with next-generation surveys.

Science.gov (United States)

Ascaso, B.

2017-03-01

The advent of next-generation surveys will provide a large number of cluster detections that will serve the basis for constraining cos mological parameters using cluster counts. The main two observational ingredients needed are the cluster selection function and the calibration of the mass-observable relation. In this talk, we present the methodology designed to obtain robust predictions of both ingredients based on realistic cosmological simulations mimicking the following next-generation surveys: J-PAS, LSST and Euclid. We display recent results on the selection functions for these mentioned surveys together with others coming from other next-generation surveys such as eROSITA, ACTpol and SPTpol. We notice that the optical and IR surveys will reach the lowest masses between 0.3next-generation surveys and introduce very preliminary results.

Unweighted event generation in hadronic WZ production at first order in QCD

CERN Document Server

Dobbs, M

2000-01-01

We present an algorithm for unweighted event generation in the partonic process pp -> WZ(j) with leptonic decays at next-to-leading order in QCD. Monte Carlo programs for processes such as this frequently generate events with negative weights in certain regions of phase space. For simulations of experimental data one would like to have unweighted events only. We demonstrate how the phase space from the matrix elements can be combined to achieve unweighted event generation using a second stage Monte Carlo integration over a volume of real emissions (jets). Observable quantities are kept fixed in the laboratory frame throughout the integration. The algorithm is applicable to a broader class of processes and is CPU intensive.

Morphometric variation among spawning cisco aggregations in the Laurentian Great Lakes: are historic forms still present?

Science.gov (United States)

Yule, Daniel L.; Moore, Seth A.; Ebener, Mark P.; Claramunt, Randall M.; Pratt, Thomas C.; Salawater, Lorrie L.; Connerton, Michael J.

2013-01-01

Cisco (Coregonus artedi Leseur, formerly lake herring Leucichthys artedi Leseur) populations in each of the Laurentian Great Lakes collapsed between the late 1920s and early 1960s following a multitude of stressors, and never recovered in Lakes Michigan, Erie and Ontario. Prior to their collapse, Koelz (1929) studied Leucichthys spp. in the Great Lakes basin and provided a description of their diversity. Three cisco morphotypes were described; a ‘slim terete’morphotype (L. artedi artedi), a ‘deep compressed’ morphotype (L. artedi albus), and a deep-bodied form resembling tullibee in western Canadian lakes (L. artedi manitoulinus). Based on body measurements of 159 individuals (Koelz 1929), we used discriminant function analysis (DFA) to discriminate historic morphotypes. Shapes of historic morphotypes were found to vary significantly (Pillai’s trace = 1.16, P cisco. Important discriminating measurements included body depth, eye diameter, and dorsal fin base and height. Between October-November of 2007-2011, we sampled cisco from 16 Great Lakes sites collecting digital photographs of over 1, 700 individuals. We applied the DFA model to their body measurements and classified each individual to a morphotype. Contemporary cisco from Lakes Superior, Ontario and Michigan were predominantly classified as artedi, while the most common classifications from northern Lake Huron were albus and manitoulinus. Finding historic morphotypes is encouraging because it suggests that the morphological variation present prior to their collapse still exists. We conclude that contemporary cisco having shapes matching the missing historic morphotypes in the lower lakes warrant special consideration as potential donor populations in reestablishment efforts.

Next Generation Inverter

Energy Technology Data Exchange (ETDEWEB)

Zhao, Zilai [General Motors LLC, Detroit, MI (United States); Gough, Charles [General Motors LLC, Detroit, MI (United States)

2016-04-22

The goal of this Cooperative Agreement was the development of a Next Generation Inverter for General Motors’ electrified vehicles, including battery electric vehicles, range extended electric vehicles, plug-in hybrid electric vehicles and hybrid electric vehicles. The inverter is a critical electronics component that converts battery power (DC) to and from the electric power for the motor (AC).

Technical presentation: Next Generation Oscilloscopes

CERN Multimedia

PH Department

2011-01-01

  Rohde & Schwarz "Next Generation Oscilloscopes" - Introduction and Presentation Agenda: Wednesday 23 March  -  09:30 to 11:30 (open end) Bldg. 13-2-005 Language: English 09.30 Presentation "Next Generation Oscilloscopes" from Rohde & Schwarz RTO / RTM in theory and practice Gerard Walker 10.15 Technical design details from R&D Dr. Markus Freidhof 10.45 Scope and Probe Roadmap (confidential) Guido Schulze 11.00 Open Discussion Feedback, first impression, wishes, needs and requirements from CERN All 11.30 Expert Talks, Hands on All Mr. Dr. Markus Freidhof, Head of R&D Oscilloscopes, Rohde & Schwarz, Germany; Mr. Guido Schulze, ...

Next generation toroidal devices

International Nuclear Information System (INIS)

Yoshikawa, Shoichi

1998-10-01

A general survey of the possible approach for the next generation toroidal devices was made. Either surprisingly or obviously (depending on one's view), the technical constraints along with the scientific considerations lead to a fairly limited set of systems for the most favorable approach for the next generation devices. Specifically if the magnetic field strength of 5 T or above is to be created by superconducting coils, it imposes minimum in the aspect ratio for the tokamak which is slightly higher than contemplated now for ITER design. The similar technical constraints make the minimum linear size of a stellarator large. Scientifically, it is indicated that a tokamak of 1.5 times in the linear dimension should be able to produce economically, especially if a hybrid reactor is allowed. For the next stellarator, it is strongly suggested that some kind of helical axis is necessary both for the (almost) absolute confinement of high energy particles and high stability and equilibrium beta limits. The author still favors a heliac most. Although it may not have been clearly stated in the main text, the stability afforded by the shearless layer may be exploited fully in a stellarator. (author)

Next generation toroidal devices

Energy Technology Data Exchange (ETDEWEB)

Yoshikawa, Shoichi [Princeton Plasma Physics Lab., Princeton Univ., NJ (United States)

1998-10-01

A general survey of the possible approach for the next generation toroidal devices was made. Either surprisingly or obviously (depending on one`s view), the technical constraints along with the scientific considerations lead to a fairly limited set of systems for the most favorable approach for the next generation devices. Specifically if the magnetic field strength of 5 T or above is to be created by superconducting coils, it imposes minimum in the aspect ratio for the tokamak which is slightly higher than contemplated now for ITER design. The similar technical constraints make the minimum linear size of a stellarator large. Scientifically, it is indicated that a tokamak of 1.5 times in the linear dimension should be able to produce economically, especially if a hybrid reactor is allowed. For the next stellarator, it is strongly suggested that some kind of helical axis is necessary both for the (almost) absolute confinement of high energy particles and high stability and equilibrium beta limits. The author still favors a heliac most. Although it may not have been clearly stated in the main text, the stability afforded by the shearless layer may be exploited fully in a stellarator. (author)

Isolation and characterization of microsatellite loci from the Arctic cisco (Coregonus autumnalis)

Science.gov (United States)

Ramey, A.; Graziano, S.L.; Nielsen, J.L.

2008-01-01

Eight polymorphic microsatellite loci were isolated and characterized for the Arctic cisco, Coregonus autumnalis. Loci were evaluated in 21 samples from the Colville River subsistence fishery. The number of alleles per locus ranged from two to 18. Observed heterozygosity of loci varied from 0.10 to 1.00, and expected heterozygosity ranged from 0.09 to 0.92. All eight microsatellite markers were in Hardy-Weinberg equilibrium. The loci presented here will be useful in describing population structure and exploring populations of origin for Arctic cisco. ?? 2007 Blackwell Publishing Ltd.

Males exceed females in PCB concentrations of cisco (Coregonus artedi) from Lake Superior.

Science.gov (United States)

Madenjian, Charles P; Yule, Daniel L; Chernyak, Sergei M; Begnoche, Linda J; Berglund, Eric K; Isaac, Edmund J

2014-09-15

We determined whole-fish polychlorinated biphenyl (PCB) concentrations of 25 male and 25 female age-7 ciscoes (Coregonus artedi) captured from a spawning aggregation in Thunder Bay, Lake Superior, during November 2010. We also determined PCB concentrations in the ovaries and somatic tissue of five additional female ciscoes (ages 5-22). All 55 of these ciscoes were in ripe or nearly ripe condition. Bioenergetics modeling was used to determine the contribution of the growth dilution effect toward a difference in PCB concentrations between the sexes, as females grew substantially faster than males. Results showed that the PCB concentration of males (mean = 141 ng/g) was 43% greater than that of females (mean = 98 ng/g), and this difference was highly significant (PPCB concentrations in the ovaries and the somatic tissue of the five females were 135 and 100 ng/g, respectively. Based on these PCB determinations for the ovaries and somatic tissue, we concluded that release of eggs by females at previous spawnings was not a contributing factor to the observed difference in PCB concentrations between the sexes. Bioenergetics modeling results indicated that the growth dilution effect could explain males being higher than females in PCB concentration by only 3-7%. We concluded that the higher PCB concentration in males was most likely due to higher rate of energy expenditure, originating from greater activity and a higher resting metabolic rate. Mean PCB concentration in the cisco eggs was well below the U. S. Food and Drug Administration and Ontario Ministry of Environment guidelines of 2000 and 844 ng/g, respectively, and this finding may have implications for the cisco roe fishery currently operating in Lake Superior. Published by Elsevier B.V.

Nuclear the next generation. 34th Annual Canadian Nuclear Society conference and 37th CNS/CNA student conference

Energy Technology Data Exchange (ETDEWEB)

NONE

2013-07-01

The 34th Annual Canadian Nuclear Society Conference and 37th CNS/CNA Student Conference was held in Toronto, Ontario, Canada on June 10-13, 2013. With the theme of the conference, 'Nuclear the Next Generation{sup ,} the conference actively engaged 400 participants in the many facets of this well-rum event. The conference combined excellent plenary speakers, a full set of technical papers, challenging student poster competitions, and interesting exhibits. The plenary session focussed on the themes: 'Nuclear Power - a Business Driver for the Next Generation'; and, 'Designing - the Next Generation'. The technical session titles were: Reactor and Radiation Physics; Environment and Spent Fuel Management; Operations and Maintenance; Fusion Science and Technology; Advanced Reactors and Fuels; Plant Life Extension, Refurbishment and Aging; Safety and Licensing; Chemistry and Materials; and, Thermalhydraulics. The student conference session was well attended and completed the 4 day event.

A Next Generation BioPhotonics Workstation

DEFF Research Database (Denmark)

Glückstad, Jesper; Palima, Darwin; Tauro, Sandeep

2011-01-01

We are developing a Next Generation BioPhotonics Workstation to be applied in research on regulated microbial cell growth including their underlying physiological mechanisms, in vivo characterization of cell constituents and manufacturing of nanostructures and meta-materials.......We are developing a Next Generation BioPhotonics Workstation to be applied in research on regulated microbial cell growth including their underlying physiological mechanisms, in vivo characterization of cell constituents and manufacturing of nanostructures and meta-materials....

Next Generation Microchannel Heat Exchangers

CERN Document Server

Ohadi, Michael; Dessiatoun, Serguei; Cetegen, Edvin

2013-01-01

In Next Generation Microchannel Heat Exchangers, the authors’ focus on the new generation highly efficient heat exchangers and presentation of novel data and technical expertise not available in the open literature.  Next generation micro channels offer record high heat transfer coefficients with pressure drops much less than conventional micro channel heat exchangers. These inherent features promise fast penetration into many mew markets, including high heat flux cooling of electronics, waste heat recovery and energy efficiency enhancement applications, alternative energy systems, as well as applications in mass exchangers and chemical reactor systems. The combination of up to the minute research findings and technical know-how make this book very timely as the search for high performance heat and mass exchangers that can cut costs in materials consumption intensifies.

RES-E-NEXT: Next Generation of RES-E Policy Instruments

Energy Technology Data Exchange (ETDEWEB)

Miller, M.; Bird, L.; Cochran, J.; Milligan, M.; Bazilian, M. [National Renewable Energy Laboratory, Golden, CO (United States); Denny, E.; Dillon, J.; Bialek, J.; O’Malley, M. [Ecar Limited (Ireland); Neuhoff, K. [DIW Berlin (Germany)

2013-07-04

The RES-E-NEXT study identifies policies that are required for the next phase of renewable energy support. The study analyses policy options that secure high shares of renewable electricity generation and adequate grid infrastructure, enhance flexibility and ensure an appropriate market design. Measures have limited costs or even save money, and policies can be gradually implemented.

Report on the September 2011 Meeting of the Next Generation Safegaurds Professional Network

Energy Technology Data Exchange (ETDEWEB)

Gitau, Ernest TN; Benz, Jacob M.

2011-12-19

The Next Generation Safeguards Professional Network (NGSPN) was established in 2009 by Oak Ridge National Laboratory targeted towards the engagement of young professionals employed in safeguards across the many national laboratories. NGSPN focuses on providing a mechanism for young safeguards professionals to connect and foster professional relationships, facilitating knowledge transfer between current safeguards experts and the next generation of experts, and acting as an entity to represent the interests of the international community of young and mid-career safeguards professionals. This is accomplished in part with a yearly meeting held at a national laboratory site. In 2011, this meeting was held at Pacific Northwest National Laboratory. This report documents the events and results of that meeting.

Bilingualism, Biculturalism, and the Cisco Kid Cycle

Science.gov (United States)

Keller, Gary D.

2007-01-01

The Cisco Kid was born over 100 years ago in 1907 from the pen of the genial and bilious author O. Henry (William Sydney Porter, 1862-1910). He is still going strong both in film and television. Before 1913, the year when films became long features, dozens of short films were based on the character. After 1913, feature films either used the actual…

Progress on next generation linear colliders

International Nuclear Information System (INIS)

Ruth, R.D.

1989-01-01

In this paper, I focus on reviewing the issues and progress on a next generation linear collider with the general parameters of energy, luminosity, length, power, technology. The energy range is dictated by physics with a mass reach well beyond LEP, although somewhat short of SSC. The luminosity is that required to obtain 10 3 /minus/ 10 4 units of R 0 per year. The length is consistent with a site on Stanford land with collisions occurring on the SLAC site. The power was determined by economic considerations. Finally, the technology was limited by the desire to have a next generation linear collider before the next century. 25 refs., 3 figs., 6 tabs

Next generation of accelerators

International Nuclear Information System (INIS)

Richter, B.

1979-01-01

Existing high-energy accelerators are reviewed, along with those under construction or being designed. Finally, some of the physics issues which go into setting machine parameters, and some of the features of the design of next generation electron and proton machines are discussed

Prospects for next-generation e+e- linear colliders

International Nuclear Information System (INIS)

Ruth, R.D.

1990-02-01

The purpose of this paper is to review progress in the US towards a next generation linear collider. During 1988, there were three workshops held on linear colliders: ''Physics of Linear Colliders,'' in Capri, Italy, June 14--18, 1988; Snowmass 88 (Linear Collider subsection) June 27--July 15, 1988; and SLAC International Workshop on Next Generation Linear Colliders, November 28--December 9, 1988. In this paper, I focus on reviewing the issues and progress on a next generation linear collider. The energy range is dictated by physics with a mass reach well beyond LEP, although somewhat short of SSC. The luminosity is that required to obtain 10 3 --10 4 units of R 0 per year. The length is consistent with a site on Stanford land with collision occurring on the SLAC site; the power was determined by economic considerations. Finally, the technology as limited by the desire to have a next generation linear collider by the next century. 37 refs., 3 figs., 6 tabs

Energy study of heat pumps and energy storage at Cisco Systems International; Energiestudie warmtepompen en energieopslag Cisco Systems International

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-05-23

Cisco Systems International considers the use of energy storage in combination with heat pumps for the new office building in Amsterdam South-East, Netherlands. This office building has a floor space of 35,000 m{sup 2}. In a later phase this can be enlarged to 45,000 m{sup 2} (phase 1b) or 90,000 m{sup 2} (phase 2). This study is based on phase 1b. The mounting heat capacity is 2,760 kW and the cooling capacity is 7,045 kW. The annually cooling demand is estimated to be 30,400 MWh/a. The computer cooling forms a greater part of the cooling request (28,300 MWh/a). This study is a pilot study to the applicability of subsurface energy storage where heat pumps in the new office building are involved. However, nearby the Cisco location IKEA (furniture warehouse) has also planned an energy storage system. Therefore, the interaction between the two storage systems was examined. Cost effectiveness was analysed by comparison of the storage system with an energy system using conventional cooling machines and gas boilers. 5 refs.

Overview of NASA's Next Generation Air Transportation System (NextGen) Research

Science.gov (United States)

Swenson, Harry N.

2009-01-01

This slide presentation is an overview of the research for the Next Generation Air Transportation System (NextGen). Included is a review of the current air transportation system and the challenges of air transportation research. Also included is a review of the current research highlights and significant accomplishments.

Foraging and predation risk for larval cisco (Coregonus artedi) in Lake Superior: a modelling synthesis of empirical survey data

Science.gov (United States)

Myers, Jared T.; Yule, Daniel L.; Jones, Michael L.; Quinlan, Henry R.; Berglund, Eric K.

2014-01-01

The relative importance of predation and food availability as contributors to larval cisco (Coregonus artedi) mortality in Lake Superior were investigated using a visual foraging model to evaluate potential predation pressure by rainbow smelt (Osmerus mordax) and a bioenergetic model to evaluate potential starvation risk. The models were informed by observations of rainbow smelt, larval cisco, and zooplankton abundance at three Lake Superior locations during the period of spring larval cisco emergence and surface-oriented foraging. Predation risk was highest at Black Bay, ON, where average rainbow smelt densities in the uppermost 10 m of the water column were >1000 ha−1. Turbid conditions at the Twin Ports, WI-MN, affected larval cisco predation risk because rainbow smelt remained suspended in the upper water column during daylight, placing them alongside larval cisco during both day and night hours. Predation risk was low at Cornucopia, WI, owing to low smelt densities (cisco survival at Black Bay and to a lesser extent at Twin Ports, and that starvation may be a major source of mortality at all three locations. The framework we describe has the potential to further our understanding of the relative importance of starvation and predation on larval fish survivorship, provided information on prey resources available to larvae are measured at sufficiently fine spatial scales and the models provide a realistic depiction of the dynamic processes that the larvae experience.

Next Generation Social Networks

DEFF Research Database (Denmark)

Sørensen, Lene Tolstrup; Skouby, Knud Erik

2008-01-01

different online networks for communities of people who share interests or individuals who presents themselves through user produced content is what makes up the social networking of today. The purpose of this paper is to discuss perceived user requirements to the next generation social networks. The paper...

Next generation CANDU plants

International Nuclear Information System (INIS)

Hedges, K.R.; Yu, S.K.W.

1998-01-01

Future CANDU designs will continue to meet the emerging design and performance requirements expected by the operating utilities. The next generation CANDU products will integrate new technologies into both the product features as well as into the engineering and construction work processes associated with delivering the products. The timely incorporation of advanced design features is the approach adopted for the development of the next generation of CANDU. AECL's current products consist of 700MW Class CANDU 6 and 900 MW Class CANDU 9. Evolutionary improvements are continuing with our CANDU products to enhance their adaptability to meet customers ever increasing need for higher output. Our key product drivers are for improved safety, environmental protection and improved cost effectiveness. Towards these goals we have made excellent progress in Research and Development and our investments are continuing in areas such as fuel channels and passive safety. Our long term focus is utilizing the fuel cycle flexibility of CANDU reactors as part of the long term energy mix

Optical Subsystems for Next Generation Access Networks

DEFF Research Database (Denmark)

Lazaro, J.A; Polo, V.; Schrenk, B.

2011-01-01

Recent optical technologies are providing higher flexibility to next generation access networks: on the one hand, providing progressive FTTx and specifically FTTH deployment, progressively shortening the copper access network; on the other hand, also opening fixed-mobile convergence solutions...... in next generation PON architectures. It is provided an overview of the optical subsystems developed for the implementation of the proposed NG-Access Networks....

Building next-generation converged networks theory and practice

CERN Document Server

Pathan, Al-Sakib Khan

2013-01-01

Supplying a comprehensive introduction to next-generation networks, Building Next-Generation Converged Networks: Theory and Practice strikes a balance between how and why things work and how to make them work. It compiles recent advancements along with basic issues from the wide range of fields related to next generation networks. Containing the contributions of 56 industry experts and researchers from 16 different countries, the book presents relevant theoretical frameworks and the latest research. It investigates new technologies such as IPv6 over Low Power Wireless Personal Area Network (6L

Key thrusts in next generation CANDU. Annex 10

International Nuclear Information System (INIS)

Shalaby, B.A.; Torgerson, D.F.; Duffey, R.B.

2002-01-01

Current electricity markets and the competitiveness of other generation options such as CCGT have influenced the directions of future nuclear generation. The next generation CANDU has used its key characteristics as the basis to leap frog into a new design featuring improved economics, enhanced passive safety, enhanced operability and demonstrated fuel cycle flexibility. Many enabling technologies spinning of current CANDU design features are used in the next generation design. Some of these technologies have been developed in support of existing plants and near term designs while others will need to be developed and tested. This paper will discuss the key principles driving the next generation CANDU design and the fuel cycle flexibility of the CANDU system which provide synergism with the PWR fuel cycle. (author)

Next Generation Biopharmaceuticals: Product Development.

Science.gov (United States)

Mathaes, Roman; Mahler, Hanns-Christian

2018-04-11

Therapeutic proteins show a rapid market growth. The relatively young biotech industry already represents 20 % of the total global pharma market. The biotech industry environment has traditionally been fast-pasted and intellectually stimulated. Nowadays the top ten best selling drugs are dominated by monoclonal antibodies (mABs).Despite mABs being the biggest medical breakthrough in the last 25 years, technical innovation does not stand still.The goal remains to preserve the benefits of a conventional mAB (serum half-life and specificity) whilst further improving efficacy and safety and to open new and better avenues for treating patients, e.g., improving the potency of molecules, target binding, tissue penetration, tailored pharmacokinetics, and reduced adverse effects or immunogenicity.The next generation of biopharmaceuticals can pose specific chemistry, manufacturing, and control (CMC) challenges. In contrast to conventional proteins, next-generation biopharmaceuticals often require lyophilization of the final drug product to ensure storage stability over shelf-life time. In addition, next-generation biopharmaceuticals require analytical methods that cover different ways of possible degradation patterns and pathways, and product development is a long way from being straight forward. The element of "prior knowledge" does not exist equally for most novel formats compared to antibodies, and thus the assessment of critical quality attributes (CQAs) and the definition of CQA assessment criteria and specifications is difficult, especially in early-stage development.

NASA's Next Generation Space Geodesy Network

Science.gov (United States)

Desai, S. D.; Gross, R. S.; Hilliard, L.; Lemoine, F. G.; Long, J. L.; Ma, C.; McGarry, J. F.; Merkowitz, S. M.; Murphy, D.; Noll, C. E.;

Comparison of genetic and visual identification of cisco and lake whitefish larvae from Chaumont Bay, Lake Ontario

Science.gov (United States)

George, Ellen M.; Hare, Matthew P.; Crabtree, Darran L.; Lantry, Brian F.; Rudstam, Lars G.

2017-01-01

Cisco Coregonus artedi are an important component of native food webs in the Great Lakes, and their restoration is instrumental to the recovery of lake trout Salvelinus namaycush and Atlantic salmon Salmo salar. Difficulties with visual identification of larvae can confound early life history surveys, as cisco are often difficult to distinguish from lake whitefish C. clupeaformis. We compared traditional visual species identification methods to genetic identifications based on barcoding of the mitochondrial cytochrome C oxidase I gene for 726 coregonine larvae caught in Chaumont Bay, Lake Ontario. We found little agreement between the visual characteristics of cisco identified by genetic barcoding and the most widely used dichotomous key, and the considerable overlap in ranges of traditionally utilized metrics suggest that visual identification of coregonine larvae from Chaumont Bay is impractical. Coregonines are highly variable and plastic species, and often display wide variations in morphometric characteristics across their broad range. This study highlights the importance of developing accurate, geographically appropriate larval identification methods in order to best inform cisco restoration and management efforts.

Next Generation Solar Collectors for CSP

Energy Technology Data Exchange (ETDEWEB)

Molnar, Attila [3M Company, St. Paul, MN (United States); Charles, Ruth [3M Company, St. Paul, MN (United States)

2014-07-31

The intent of “Next Generation Solar Collectors for CSP” program was to develop key technology elements for collectors in Phase 1 (Budget Period 1), design these elements in Phase 2 (Budget Period 2) and to deploy and test the final collector in Phase 3 (Budget Period 3). 3M and DOE mutually agreed to terminate the program at the end of Budget Period 1, primarily due to timeline issues. However, significant advancements were achieved in developing a next generation reflective material and panel that has the potential to significantly improve the efficiency of CSP systems.

Cisco Networking Academy Program for high school students: Formative & summative evaluation

Science.gov (United States)

Cranford-Wesley, Deanne

This study examined the effectiveness of the Cisco Network Technology Program in enhancing students' technology skills as measured by classroom strategies, student motivation, student attitude, and student learning. Qualitative and quantitative methods were utilized to determine the effectiveness of this program. The study focused on two 11th grade classrooms at Hamtramck High School. Hamtramck, an inner-city community located in Detroit, is racially and ethnically diverse. The majority of students speak English as a second language; more than 20 languages are represented in the school district. More than 70% of the students are considered to be economically at risk. Few students have computers at home, and their access to the few computers at school is limited. Purposive sampling was conducted for this study. The sample consisted of 40 students, all of whom were trained in Cisco Networking Technologies. The researcher examined viable learning strategies in teaching a Cisco Networking class that focused on a web-based approach. Findings revealed that the Cisco Networking Academy Program was an excellent vehicle for teaching networking skills and, therefore, helping to enhance computer skills for the participating students. However, only a limited number of students were able to participate in the program, due to limited computer labs and lack of qualified teaching personnel. In addition, the cumbersome technical language posed an obstacle to students' success in networking. Laboratory assignments were preferred by 90% of the students over lecture and PowerPoint presentations. Practical applications, lab projects, interactive assignments, PowerPoint presentations, lectures, discussions, readings, research, and assessment all helped to increase student learning and proficiency and to enrich the classroom experience. Classroom strategies are crucial to student success in the networking program. Equipment must be updated and utilized to ensure that students are

Next generation PWR

International Nuclear Information System (INIS)

Tanaka, Toshihiko; Fukuda, Toshihiko; Usui, Shuji

2001-01-01

Development of LWR for power generation in Japan has been intended to upgrade its reliability, safety, operability, maintenance and economy as well as to increase its capacity in order, since nuclear power generation for commercial use was begun on 1970, to steadily increase its generation power. And, in Japan, ABWR (advanced BWR) of the most promising LWR in the world, was already used actually and APWR (advanced PWR) with the largest output in the world is also at a step of its actual use. And, development of the APWR in Japan was begun on 1980s, and is at a step of plan on construction of its first machine at early of this century. However, by large change of social affairs, economy of nuclear power generation is extremely required, to be positioned at an APWR improved development reactor promoted by collaboration of five PWR generation companies and the Mitsubishi Electric Co., Ltd. Therefore, on its development, investigation on effect of change in social affairs on nuclear power stations was at first carried out, to establish a design requirement for the next generation PWR. Here were described on outline, reactor core design, safety concept, and safety evaluation of APWR+ and development of an innovative PWR. (G.K.)

The decline of cisco Coregonus artedi at its southern range extent: Stock biology and management implications

OpenAIRE

Honsey, Andrew E.

2014-01-01

The cisco Coregonus artedi is distributed throughout northern North America and is relegated to coldwater, oligotrophic systems. Populations of cisco located at the species' southern range extent, including northern Indiana and southern Michigan, have drastically declined over the past century, seemingly due to a combination of climate warming and exacerbation of hypolimnetic hypoxic conditions via intensive land-use and resulting increases in nutrient loading. Apart from their decline, infor...

78 FR 42036 - Radio Broadcasting Services; Port Lions, AK, De Beque, CO, Benjamin, Cisco, Rule, and Shamrock, TX

Science.gov (United States)

2013-07-15

... FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 73 [MB Docket No. 13-156; DA 13-1377] Radio Broadcasting Services; Port Lions, AK, De Beque, CO, Benjamin, Cisco, Rule, and Shamrock, TX AGENCY: Federal..., under Texas, Channel 237C3; Cisco, Channel 261C3; Rule, Channel 288C2; and Shamrock, Channel 225C2. [FR...

Real-Time Optimization and Control of Next-Generation Distribution

Science.gov (United States)

-Generation Distribution Infrastructure Real-Time Optimization and Control of Next-Generation Distribution developing a system-theoretic distribution network management framework that unifies real-time voltage and Infrastructure | Grid Modernization | NREL Real-Time Optimization and Control of Next

Hacking the next generation

CERN Document Server

Dhanjani, Nitesh; Hardin, Brett

2009-01-01

With the advent of rich Internet applications, the explosion of social media, and the increased use of powerful cloud computing infrastructures, a new generation of attackers has added cunning new techniques to its arsenal. For anyone involved in defending an application or a network of systems, Hacking: The Next Generation is one of the few books to identify a variety of emerging attack vectors. You'll not only find valuable information on new hacks that attempt to exploit technical flaws, you'll also learn how attackers take advantage of individuals via social networking sites, and abuse

The NASA Next Generation Stirling Technology Program Overview

Science.gov (United States)

Schreiber, J. G.; Shaltens, R. K.; Wong, W. A.

2005-12-01

NASAs Science Mission Directorate is developing the next generation Stirling technology for future Radioisotope Power Systems (RPS) for surface and deep space missions. The next generation Stirling convertor is one of two advanced power conversion technologies currently being developed for future NASA missions, and is capable of operating for both planetary atmospheres and deep space environments. The Stirling convertor (free-piston engine integrated with a linear alternator) produces about 90 We(ac) and has a specific power of about 90 We/kg. Operating conditions of Thot at 850 degree C and Trej at 90 degree C results in the Stirling convertor estimated efficiency of about 40 per cent. Using the next generation Stirling convertor in future RPS, the "system" specific power is estimated at 8 We/kg. The design lifetime is three years on the surface of Mars and fourteen years in deep space missions. Electrical power of about 160 We (BOM) is produced by two (2) free-piston Stirling convertors heated by two (2) General Purpose Heat Source (GPHS) modules. This development is being performed by Sunpower, Athens, OH with Pratt & Whitney, Rocketdyne, Canoga Park, CA under contract to Glenn Research Center (GRC), Cleveland, Ohio. GRC is guiding the independent testing and technology development for the next generation Stirling generator.

Rhamnolipids--next generation surfactants?

Science.gov (United States)

Müller, Markus Michael; Kügler, Johannes H; Henkel, Marius; Gerlitzki, Melanie; Hörmann, Barbara; Pöhnlein, Martin; Syldatk, Christoph; Hausmann, Rudolf

2012-12-31

The demand for bio-based processes and materials in the petrochemical industry has significantly increased during the last decade because of the expected running out of petroleum. This trend can be ascribed to three main causes: (1) the increased use of renewable resources for chemical synthesis of already established product classes, (2) the replacement of chemical synthesis of already established product classes by new biotechnological processes based on renewable resources, and (3) the biotechnological production of new molecules with new features or better performances than already established comparable chemically synthesized products. All three approaches are currently being pursued for surfactant production. Biosurfactants are a very promising and interesting substance class because they are based on renewable resources, sustainable, and biologically degradable. Alkyl polyglycosides are chemically synthesized biosurfactants established on the surfactant market. The first microbiological biosurfactants on the market were sophorolipids. Of all currently known biosurfactants, rhamnolipids have the highest potential for becoming the next generation of biosurfactants introduced on the market. Although the metabolic pathways and genetic regulation of biosynthesis are known qualitatively, the quantitative understanding relevant for bioreactor cultivation is still missing. Additionally, high product titers have been exclusively described with vegetable oil as sole carbon source in combination with Pseudomonas aeruginosa strains. Competitive productivity is still out of reach for heterologous hosts or non-pathogenic natural producer strains. Thus, on the one hand there is a need to gain a deeper understanding of the regulation of rhamnolipid production on process and cellular level during bioreactor cultivations. On the other hand, there is a need for metabolizable renewable substrates, which do not compete with food and feed. A sustainable bioeconomy approach should

Physical Configuration of the Next Generation Home Network

Science.gov (United States)

Terada, Shohei; Kakishima, Yu; Hanawa, Dai; Oguchi, Kimio

The number of broadband users is rapidly increasing worldwide. Japan already has over 10 million FTTH users. Another trend is the rapid digitalization of home electrical equipment e. g. digital cameras and hard disc recorders. These trends will encourage the emergence of the next generation home network. In this paper, we introduce the next generation home network image and describe the five domains into which home devices can be classified. We then clarify the optimum medium with which to configure the network given the requirements imposed by the home environment. Wiring cable lengths for three network topologies are calculated. The results gained from the next generation home network implemented on the first phase testbed are shown. Finally, our conclusions are given.

Event generators for address event representation transmitters

Science.gov (United States)

Serrano-Gotarredona, Rafael; Serrano-Gotarredona, Teresa; Linares Barranco, Bernabe

2005-06-01

Address Event Representation (AER) is an emergent neuromorphic interchip communication protocol that allows for real-time virtual massive connectivity between huge number neurons located on different chips. By exploiting high speed digital communication circuits (with nano-seconds timings), synaptic neural connections can be time multiplexed, while neural activity signals (with mili-seconds timings) are sampled at low frequencies. Also, neurons generate 'events' according to their activity levels. More active neurons generate more events per unit time, and access the interchip communication channel more frequently, while neurons with low activity consume less communication bandwidth. In a typical AER transmitter chip, there is an array of neurons that generate events. They send events to a peripheral circuitry (let's call it "AER Generator") that transforms those events to neurons coordinates (addresses) which are put sequentially on an interchip high speed digital bus. This bus includes a parallel multi-bit address word plus a Rqst (request) and Ack (acknowledge) handshaking signals for asynchronous data exchange. There have been two main approaches published in the literature for implementing such "AER Generator" circuits. They differ on the way of handling event collisions coming from the array of neurons. One approach is based on detecting and discarding collisions, while the other incorporates arbitration for sequencing colliding events . The first approach is supposed to be simpler and faster, while the second is able to handle much higher event traffic. In this article we will concentrate on the second arbiter-based approach. Boahen has been publishing several techniques for implementing and improving the arbiter based approach. Originally, he proposed an arbitration squeme by rows, followed by a column arbitration. In this scheme, while one neuron was selected by the arbiters to transmit his event out of the chip, the rest of neurons in the array were

Genetics, recruitment, and migration patterns of Arctic Cisco (Coregonus autumnalis) in the Colville River, Alaska and Mackenzie River, Canada

Science.gov (United States)

Zimmerman, Christian E.; Ramey, Andy M.; Turner, S.; Mueter, Franz J.; Murphy, S.; Nielsen, Jennifer L.

2013-01-01

Arctic cisco Coregonus autumnalis have a complex anadromous life history, many aspects of which remain poorly understood. Some life history traits of Arctic cisco from the Colville River, Alaska, and Mackenzie River basin, Canada, were investigated using molecular genetics, harvest data, and otolith microchemistry. The Mackenzie hypothesis, which suggests that Arctic cisco found in Alaskan waters originate from the Mackenzie River system, was tested using 11 microsatellite loci and a single mitochondrial DNA gene. No genetic differentiation was found among sample collections from the Colville River and the Mackenzie River system using molecular markers (P > 0.19 in all comparisons). Model-based clustering methods also supported genetic admixture between sample collections from the Colville River and Mackenzie River basin. A reanalysis of recruitment patterns to Alaska, which included data from recent warm periods and suspected changes in atmospheric circulation patterns, still finds that recruitment is correlated to wind conditions. Otolith microchemistry (Sr/Ca ratios) confirmed repeated, annual movements of Arctic cisco between low-salinity habitats in winter and marine waters in summer.

Next generation vaccines.

Science.gov (United States)

Riedmann, Eva M

2011-07-01

In February this year, about 100 delegates gathered for three days in Vienna (Austria) for the Next Generation Vaccines conference. The meeting held in the Vienna Hilton Hotel from 23rd-25th February 2011 had a strong focus on biotech and industry. The conference organizer Jacob Fleming managed to put together a versatile program ranging from the future generation of vaccines to manufacturing, vaccine distribution and delivery, to regulatory and public health issues. Carefully selected top industry experts presented first-hand experience and shared solutions for overcoming the latest challenges in the field of vaccinology. The program also included several case study presentations on novel vaccine candidates in different stages of development. An interactive pre-conference workshop as well as interactive panel discussions during the meeting allowed all delegates to gain new knowledge and become involved in lively discussions on timely, interesting and sometimes controversial topics related to vaccines.

NOAA NEXt-Generation RADar (NEXRAD) Products

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This dataset consists of Level III weather radar products collected from Next-Generation Radar (NEXRAD) stations located in the contiguous United States, Alaska,...

The Next Generation Science Standards

Science.gov (United States)

Pruitt, Stephen L.

2015-01-01

The Next Generation Science Standards (NGSS Lead States 2013) were released almost two years ago. Work tied to the NGSS, their adoption, and implementation continues to move forward around the country. Stephen L. Pruitt, senior vice president, science, at Achieve, an independent, nonpartisan, nonprofit education reform organization that was a lead…

Next Generation Enterprise Network Business Continuity: Maintaining Operations In A Compromised Environment

Science.gov (United States)

2016-03-01

virtualization, available technology products currently on the market , and tactics for employing virtualized environments, this research explores whether...Evaluating published literature on virtualization, available technology products currently on the market , and tactics for employing virtualized environments...are commercially available and are developed by mature companies. Cisco offers collaboration tailored to virtual environments as part of Business

Pharmacokinetic and pharmacodynamic considerations for the next generation protein therapeutics.

Science.gov (United States)

Shah, Dhaval K

2015-10-01

Increasingly sophisticated protein engineering efforts have been undertaken lately to generate protein therapeutics with desired properties. This has resulted in the discovery of the next generation of protein therapeutics, which include: engineered antibodies, immunoconjugates, bi/multi-specific proteins, antibody mimetic novel scaffolds, and engineered ligands/receptors. These novel protein therapeutics possess unique physicochemical properties and act via a unique mechanism-of-action, which collectively makes their pharmacokinetics (PK) and pharmacodynamics (PD) different than other established biological molecules. Consequently, in order to support the discovery and development of these next generation molecules, it becomes important to understand the determinants controlling their PK/PD. This review discusses the determinants that a PK/PD scientist should consider during the design and development of next generation protein therapeutics. In addition, the role of systems PK/PD models in enabling rational development of the next generation protein therapeutics is emphasized.

Enhancing Next-Generation Sequencing-Guided Cancer Care Through Cognitive Computing.

Science.gov (United States)

Patel, Nirali M; Michelini, Vanessa V; Snell, Jeff M; Balu, Saianand; Hoyle, Alan P; Parker, Joel S; Hayward, Michele C; Eberhard, David A; Salazar, Ashley H; McNeillie, Patrick; Xu, Jia; Huettner, Claudia S; Koyama, Takahiko; Utro, Filippo; Rhrissorrakrai, Kahn; Norel, Raquel; Bilal, Erhan; Royyuru, Ajay; Parida, Laxmi; Earp, H Shelton; Grilley-Olson, Juneko E; Hayes, D Neil; Harvey, Stephen J; Sharpless, Norman E; Kim, William Y

2018-02-01

Using next-generation sequencing (NGS) to guide cancer therapy has created challenges in analyzing and reporting large volumes of genomic data to patients and caregivers. Specifically, providing current, accurate information on newly approved therapies and open clinical trials requires considerable manual curation performed mainly by human "molecular tumor boards" (MTBs). The purpose of this study was to determine the utility of cognitive computing as performed by Watson for Genomics (WfG) compared with a human MTB. One thousand eighteen patient cases that previously underwent targeted exon sequencing at the University of North Carolina (UNC) and subsequent analysis by the UNCseq informatics pipeline and the UNC MTB between November 7, 2011, and May 12, 2015, were analyzed with WfG, a cognitive computing technology for genomic analysis. Using a WfG-curated actionable gene list, we identified additional genomic events of potential significance (not discovered by traditional MTB curation) in 323 (32%) patients. The majority of these additional genomic events were considered actionable based upon their ability to qualify patients for biomarker-selected clinical trials. Indeed, the opening of a relevant clinical trial within 1 month prior to WfG analysis provided the rationale for identification of a new actionable event in nearly a quarter of the 323 patients. This automated analysis took potentially improve patient care by providing a rapid, comprehensive approach for data analysis and consideration of up-to-date availability of clinical trials. The results of this study demonstrate that the interpretation and actionability of somatic next-generation sequencing results are evolving too rapidly to rely solely on human curation. Molecular tumor boards empowered by cognitive computing can significantly improve patient care by providing a fast, cost-effective, and comprehensive approach for data analysis in the delivery of precision medicine. Patients and physicians who

IPv6: The Next Generation Internet Protocol

Indian Academy of Sciences (India)

addressing, new generation internet. 2. ... required the creation of the next generation of Internet ... IPv6 standards have defined the following Extension headers ..... addresses are represented as x:x:x:x:x:x:x:x, where each x is the hexadecimal ...

PERMANENT GENETIC RESOURCES: Isolation and characterization of microsatellite loci from the Arctic cisco (Coregonus autumnalis).

Science.gov (United States)

Ramey, A; Graziano, S L; Nielsen, J L

2008-03-01

Eight polymorphic microsatellite loci were isolated and characterized for the Arctic cisco, Coregonus autumnalis. Loci were evaluated in 21 samples from the Colville River subsistence fishery. The number of alleles per locus ranged from two to 18. Observed heterozygosity of loci varied from 0.10 to 1.00, and expected heterozygosity ranged from 0.09 to 0.92. All eight microsatellite markers were in Hardy-Weinberg equilibrium. The loci presented here will be useful in describing population structure and exploring populations of origin for Arctic cisco. © 2007 Blackwell Publishing Ltd No claim to original US government works.

Organização de recursos internos para o talento: estudo de caso Cisco Portugal

OpenAIRE

Jamnadas, Riddhi

2012-01-01

Mestrado em Gestão A presente investigação tem o intuito de perceber como a gestão de talento está na origem das vantagens competitivas de uma empresa tecnológica como a Cisco Systems Portugal. Para o efeito, optou-se por realizar uma entrevista (metodologia qualitativa) ao Responsável de Recursos Humanos da empresa em estudo e uma análise documental com o objectivo de compreender a estratégia e as práticas de gestão de talento efectuadas pela Cisco, no actual contexto ca...

Next-generation wireless technologies 4G and beyond

CERN Document Server

Chilamkurti, Naveen; Chaouchi, Hakima

2013-01-01

This comprehensive text/reference examines the various challenges to secure, efficient and cost-effective next-generation wireless networking. Topics and features: presents the latest advances, standards and technical challenges in a broad range of emerging wireless technologies; discusses cooperative and mesh networks, delay tolerant networks, and other next-generation networks such as LTE; examines real-world applications of vehicular communications, broadband wireless technologies, RFID technology, and energy-efficient wireless communications; introduces developments towards the 'Internet o

Next Generation of Photovoltaics New Concepts

CERN Document Server

Vega, Antonio; López, Antonio

2012-01-01

This book presents new concepts for a next generation of PV. Among these concepts are: Multijunction solar cells, multiple excitation solar cells (or how to take benefit of high energy photons for the creation of more than one electron hole-pair), intermediate band solar cells (or how to take advantage of below band-gap energy photons) and related technologies (for quantum dots, nitrides, thin films), advanced light management approaches (plasmonics). Written by world-class experts in next generation photovoltaics this book is an essential reference guide accessible to both beginners and experts working with solar cell technology. The book deeply analyzes the current state-of-the-art of the new photovoltaic approaches and outlines the implementation paths of these advanced devices. Topics addressed range from the fundamentals to the description of state-of-the-art of the new types of solar cells.

Next generation biofuel engineering in prokaryotes

Science.gov (United States)

Gronenberg, Luisa S.; Marcheschi, Ryan J.; Liao, James C.

2014-01-01

Next-generation biofuels must be compatible with current transportation infrastructure and be derived from environmentally sustainable resources that do not compete with food crops. Many bacterial species have unique properties advantageous to the production of such next-generation fuels. However, no single species possesses all characteristics necessary to make high quantities of fuels from plant waste or CO2. Species containing a subset of the desired characteristics are used as starting points for engineering organisms with all desired attributes. Metabolic engineering of model organisms has yielded high titer production of advanced fuels, including alcohols, isoprenoids and fatty acid derivatives. Technical developments now allow engineering of native fuel producers, as well as lignocellulolytic and autotrophic bacteria, for the production of biofuels. Continued research on multiple fronts is required to engineer organisms for truly sustainable and economical biofuel production. PMID:23623045

Next generation of photovoltaics. New concepts

Energy Technology Data Exchange (ETDEWEB)

Cristobal Lopez, Ana Belen; Marti Vega, Antonio; Luque Lopez, Antonio (eds.) [Univ. Politecnica de Madrid (Spain). Inst. de Energia Solar E.T.S.I. Telecomunicacion

2012-07-01

This book presents new concepts for a next generation of PV. Among these concepts are: Multijunction solar cells, multiple excitation solar cells (or how to take benefit of high energy photons for the creation of more than one electron hole-pair), intermediate band solar cells (or how to take advantage of below band-gap energy photons) and related technologies (for quantum dots, nitrides, thin films), advanced light management approaches (plasmonics). Written by world-class experts in next generation photovoltaics this book is an essential reference guide accessible to both beginners and experts working with solar cell technology. The book deeply analyzes the current state-of-the-art of the new photovoltaic approaches and outlines the implementation paths of these advanced devices. Topics addressed range from the fundamentals to the description of state-of-the-art of the new types of solar cells. (orig.)

Galaxy LIMS for next-generation sequencing

NARCIS (Netherlands)

Scholtalbers, J.; Rossler, J.; Sorn, P.; Graaf, J. de; Boisguerin, V.; Castle, J.; Sahin, U.

2013-01-01

SUMMARY: We have developed a laboratory information management system (LIMS) for a next-generation sequencing (NGS) laboratory within the existing Galaxy platform. The system provides lab technicians standard and customizable sample information forms, barcoded submission forms, tracking of input

Next-generation Digital Earth.

Science.gov (United States)

Goodchild, Michael F; Guo, Huadong; Annoni, Alessandro; Bian, Ling; de Bie, Kees; Campbell, Frederick; Craglia, Max; Ehlers, Manfred; van Genderen, John; Jackson, Davina; Lewis, Anthony J; Pesaresi, Martino; Remetey-Fülöpp, Gábor; Simpson, Richard; Skidmore, Andrew; Wang, Changlin; Woodgate, Peter

2012-07-10

A speech of then-Vice President Al Gore in 1998 created a vision for a Digital Earth, and played a role in stimulating the development of a first generation of virtual globes, typified by Google Earth, that achieved many but not all the elements of this vision. The technical achievements of Google Earth, and the functionality of this first generation of virtual globes, are reviewed against the Gore vision. Meanwhile, developments in technology continue, the era of "big data" has arrived, the general public is more and more engaged with technology through citizen science and crowd-sourcing, and advances have been made in our scientific understanding of the Earth system. However, although Google Earth stimulated progress in communicating the results of science, there continue to be substantial barriers in the public's access to science. All these factors prompt a reexamination of the initial vision of Digital Earth, and a discussion of the major elements that should be part of a next generation.

Distributed Data Collection For Next Generation ATLAS EventIndex Project

CERN Document Server

Fernandez Casani, Alvaro; The ATLAS collaboration

2018-01-01

The ATLAS EventIndex currently runs in production in order to build a complete catalogue of events for experiments with large amounts of data. The current approach is to index all final produced data files at CERN Tier0, and at hundreds of grid sites, with a distributed data collection architecture using Object Stores to temporary maintain the conveyed information, with references to them sent with a Messaging System. The final backend of all the indexed data is a central Hadoop infrastructure at CERN; an Oracle relational database is used for faster access to a subset of this information. In the future of ATLAS, instead of files, the event should be the atomic information unit for metadata. This motivation arises in order to accommodate future data processing and storage technologies. Files will no longer be static quantities, possibly dynamically aggregating data, and also allowing event-level granularity processing in heavily parallel computing environments. It also simplifies the handling of loss and or e...

Next Generation NASA Initiative for Space Geodesy

Science.gov (United States)

Merkowitz, S. M.; Desai, S.; Gross, R. S.; Hilliard, L.; Lemoine, F. G.; Long, J. L.; Ma, C.; McGarry J. F.; Murphy, D.; Noll, C. E.;

Next-generation fiber lasers enabled by high-performance components

Science.gov (United States)

Kliner, D. A. V.; Victor, B.; Rivera, C.; Fanning, G.; Balsley, D.; Farrow, R. L.; Kennedy, K.; Hampton, S.; Hawke, R.; Soukup, E.; Reynolds, M.; Hodges, A.; Emery, J.; Brown, A.; Almonte, K.; Nelson, M.; Foley, B.; Dawson, D.; Hemenway, D. M.; Urbanek, W.; DeVito, M.; Bao, L.; Koponen, J.; Gross, K.

2018-02-01

Next-generation industrial fiber lasers enable challenging applications that cannot be addressed with legacy fiber lasers. Key features of next-generation fiber lasers include robust back-reflection protection, high power stability, wide power tunability, high-speed modulation and waveform generation, and facile field serviceability. These capabilities are enabled by high-performance components, particularly pump diodes and optical fibers, and by advanced fiber laser designs. We summarize the performance and reliability of nLIGHT diodes, fibers, and next-generation industrial fiber lasers at power levels of 500 W - 8 kW. We show back-reflection studies with up to 1 kW of back-reflected power, power-stability measurements in cw and modulated operation exhibiting sub-1% stability over a 5 - 100% power range, and high-speed modulation (100 kHz) and waveform generation with a bandwidth 20x higher than standard fiber lasers. We show results from representative applications, including cutting and welding of highly reflective metals (Cu and Al) for production of Li-ion battery modules and processing of carbon fiber reinforced polymers.

AugerNext: innovative research studies for the next generation ground-based ultra-high energy cosmic ray experiment

Directory of Open Access Journals (Sweden)

Haungs Andreas

2013-06-01

Full Text Available The findings so far of the Pierre Auger Observatory and also of the Telescope Array define the requirements for a possible next generation experiment: it needs to be considerably increased in size, it needs a better sensitivity to composition, and it should cover the full sky. AugerNext aims to perform innovative research studies in order to prepare a proposal fulfilling these demands. Such R&D studies are primarily focused in the following areas iconsolidation of the detection of cosmic rays using MHz radio antennas; iiproof-of-principle of cosmic-ray microwave detection; iiitest of the large-scale application of a new generation photo-sensors; ivgeneralization of data communication techniques; vdevelopment of new ways of muon detection with surface arrays. These AugerNext studies on new innovative detection methods for a next generation cosmic-ray experiment are performed at the Pierre Auger Observatory. The AugerNext consortium consists presently of fourteen partner institutions from nine European countries supported by a network of European funding agencies and it is a principal element of the ASPERA/ApPEC strategic roadmaps.

Next Generation Nuclear Plant GAP Analysis Report

Energy Technology Data Exchange (ETDEWEB)

Ball, Sydney J [ORNL; Burchell, Timothy D [ORNL; Corwin, William R [ORNL; Fisher, Stephen Eugene [ORNL; Forsberg, Charles W. [Massachusetts Institute of Technology (MIT); Morris, Robert Noel [ORNL; Moses, David Lewis [ORNL

2008-12-01

As a follow-up to the phenomena identification and ranking table (PIRT) studies conducted recently by NRC on next generation nuclear plant (NGNP) safety, a study was conducted to identify the significant 'gaps' between what is needed and what is already available to adequately assess NGNP safety characteristics. The PIRT studies focused on identifying important phenomena affecting NGNP plant behavior, while the gap study gives more attention to off-normal behavior, uncertainties, and event probabilities under both normal operation and postulated accident conditions. Hence, this process also involved incorporating more detailed evaluations of accident sequences and risk assessments. This study considers thermal-fluid and neutronic behavior under both normal and postulated accident conditions, fission product transport (FPT), high-temperature metals, and graphite behavior and their effects on safety. In addition, safety issues related to coupling process heat (hydrogen production) systems to the reactor are addressed, given the limited design information currently available. Recommendations for further study, including analytical methods development and experimental needs, are presented as appropriate in each of these areas.

Analysis of Cisco Open Network Environment (ONE) OpenFlow Controller Implementation

Science.gov (United States)

2014-08-01

Software - Defined Networking ( SDN ), when fully realized, offer many improvements over the current rigid and...functionalities like handshake, connection setup, switch management, and security. 15. SUBJECT TERMS OpenFlow, software - defined networking , Cisco ONE, SDN ...innovating packet-forwarding technologies. Network device roles are strictly defined with little or no flexibility. In Software - Defined Networks ( SDNs ),

Sistema de traducción de comandos de CISCO a AVAYA

Directory of Open Access Journals (Sweden)

Darwin Ramiro Mercado Polo

2010-01-01

Full Text Available Es especialmente relevante para la formación de los ingenieros de sistemas y profesionales de carreras afines, adquirir las competencias relacionadas con la configuración de dispositivos de comunicaciones presentes en redes informáticas, por tanto es muy importante que el estudiante aprenda a manejar una gran variedad de comandos aplicables en tales dispositivos. Los comandos varían de un dispositivo a otro, dependiendo de la empresa manufacturera, algunas de ellas son: CISCO System, AVAYA y Nortel Networks. Las arquitecturas desarrolladas por estas empresas son configurables tanto en el ámbito de la LAN como el de la WAN. En este artículo se muestra como resultado de una investigación, un software que posibilita la traducción de comandos de CISCO a AVAYA, teniendo en cuenta que para esta traducción se utilizaron diferentes técnicas y herramientas de los lenguajes formales y gramáticas, aplicando las etapas iniciales de un traductor como: las etapas de análisis léxico y sintáctico.

New materials for next-generation commercial transports

National Research Council Canada - National Science Library

Committee on New Materials for Advanced Civil Aircraft, Commission on Engineering and Technical Systems, National Research Council

... civil aircraft throughout their service life. The committee investigated the new materials and structural concepts that are likely to be incorporated into next generation commercial aircraft and the factors influencing application decisions...

Preparation of next generation set of group cross sections. 3

International Nuclear Information System (INIS)

Kaneko, Kunio

2002-03-01

This fiscal year, based on the examination result about the evaluation energy range of heavy element unresolved resonance cross sections, the upper energy limit of the energy range, where ultra-fine group cross sections are produced, was raised to 50 keV, and an improvement of the group cross section processing system was promoted. At the same time, reflecting the result of studies carried out till now, a function producing delayed neutron data was added to the general-purpose group cross section processing system , thus the preparation of general purpose group cross section processing system has been completed. On the other hand, the energy structure, data constitution and data contents of next generation group cross section set were determined, and the specification of a 151 groups next generation group cross section set was defined. Based on the above specification, a concrete library format of the next generation cross section set has been determined. After having carried out the above-described work, using the general-purpose group cross section processing system , which was complete in this study, with use of the JENDL-3. 2 evaluated nuclear data, the 151 groups next generation group cross section of 92 nuclides and the ultra fine group resonance cross section library for 29 nuclides have been prepared. Utilizing the 151 groups next generation group cross section set and the ultra-fine group resonance cross-section library, a bench mark test calculation of fast reactors has been performed by using an advanced lattice calculation code. It was confirmed, by comparing the calculation result with a calculation result of continuous energy Monte Carlo code, that the 151 groups next generation cross section set has sufficient accuracy. (author)

CCNA Cisco Certified Network Associate Deluxe Study Guide

CERN Document Server

Lammle, Todd

2011-01-01

Deluxe Edition of Best-Selling CCNA Study GuideThis comprehensive, enhanced version of the Sybex CCNA Study Guide provides certification candidates with the additional tools they need to prepare for this popular exam. With additional bonus exams and flashcards, as well as the exclusive CCNA Virtual Lab, Platinum Edition, this comprehensive guide has been completely updated to reflect the latest CCNA 640-802 exam. Written by Cisco Authority Todd Lammle, whose straightforward style provides lively examples, hands-on and written labs, easy-to-understand analogies, and real-world scenarios that wi

PENGEMBANGAN MODUL SISTEM KEAMANAN JARINGAN BERBASIS SIMULASI CISCO

Directory of Open Access Journals (Sweden)

Zulkipli Zulkipli

2016-03-01

Tujuan penelitian adalah untuk menghasilkan dan menguji kelayakan modul sistem keamanan jaringan berbasis simulasi Cisco Paket Tracer untuk peserta didik SMK. Model pengembangan yang digunakan adalah model Dick, Carey & Carey dengan sembilan langkah. Pengembangan produk ini divalidasi oleh ahli materi dengan tingkat kevalidan 96%, ahli media dengan tingkat kevalidan 92.8%, ahli desain pembelajaran dengan tingkat kevalidan 83%, uji coba perorangan dengan tingkat kevalidan 92.3%, uji coba kelompok kecil dengan tingkat kevalidan 92% dan uji coba lapangan dengan tingkat kevalidan 89% dengan kualifikasi sangat layak tidak perlu revisi.

MadEvent: automatic event generation with MadGraph

International Nuclear Information System (INIS)

Maltoni, Fabio; Stelzer, Tim

2003-01-01

We present a new multi-channel integration method and its implementation in the multi-purpose event generator MadEvent, which is based on MadGraph. Given a process, MadGraph automatically identifies all the relevant subprocesses, generates both the amplitudes and the mappings needed for an efficient integration over the phase space, and passes them to MadEvent. As a result, a process-specific, stand-alone code is produced that allows the user to calculate cross sections and produce unweighted events in a standard output format. Several examples are given for processes that are relevant for physics studies at present and forthcoming colliders. (author)

Implementing the Next Generation Science Standards

Science.gov (United States)

Penuel, William R.; Harris, Christopher J.; DeBarger, Angela Haydel

2015-01-01

The Next Generation Science Standards embody a new vision for science education grounded in the idea that science is both a body of knowledge and a set of linked practices for developing knowledge. The authors describe strategies that they suggest school and district leaders consider when designing strategies to support NGSS implementation.

Next-Generation Sequencing Platforms

Science.gov (United States)

Mardis, Elaine R.

2013-06-01

Automated DNA sequencing instruments embody an elegant interplay among chemistry, engineering, software, and molecular biology and have built upon Sanger's founding discovery of dideoxynucleotide sequencing to perform once-unfathomable tasks. Combined with innovative physical mapping approaches that helped to establish long-range relationships between cloned stretches of genomic DNA, fluorescent DNA sequencers produced reference genome sequences for model organisms and for the reference human genome. New types of sequencing instruments that permit amazing acceleration of data-collection rates for DNA sequencing have been developed. The ability to generate genome-scale data sets is now transforming the nature of biological inquiry. Here, I provide an historical perspective of the field, focusing on the fundamental developments that predated the advent of next-generation sequencing instruments and providing information about how these instruments work, their application to biological research, and the newest types of sequencers that can extract data from single DNA molecules.

On fire risk/methodology for the next generation of reactors and nuclear facilities

International Nuclear Information System (INIS)

Majumdar, K.C.; Alesso, H.P.; Altenbach, T.J.

1992-01-01

Methodologies for including fire in probabilistic risk assessments (PRAs) have been evolving during the last ten years. Many of these studies show that fire risk constitutes a significant percentage of external events, as well as the total core damage frequency. This paper summarizes the methodologies used in the fire risk analysis of the next generation of reactors and existing DOE nuclear facilities. Methodologies used in other industries, as well as existing nuclear power plants, are also discussed. Results of fire risk studies for various nuclear plants and facilities are shown and compared

Unbundling in Current Broadband and Next-Generation Ultra-Broadband Access Networks

Science.gov (United States)

Gaudino, Roberto; Giuliano, Romeo; Mazzenga, Franco; Valcarenghi, Luca; Vatalaro, Francesco

2014-05-01

This article overviews the methods that are currently under investigation for implementing multi-operator open-access/shared-access techniques in next-generation access ultra-broadband architectures, starting from the traditional "unbundling-of-the-local-loop" techniques implemented in legacy twisted-pair digital subscriber line access networks. A straightforward replication of these copper-based unbundling-of-the-local-loop techniques is usually not feasible on next-generation access networks, including fiber-to-the-home point-to-multipoint passive optical networks. To investigate this issue, the article first gives a concise description of traditional copper-based unbundling-of-the-local-loop solutions, then focalizes on both next-generation access hybrid fiber-copper digital subscriber line fiber-to-the-cabinet scenarios and on fiber to the home by accounting for the mix of regulatory and technological reasons driving the next-generation access migration path, focusing mostly on the European situation.

Adaptación del uso de routers CISCO en prácticas de laboratorio a routers Open-Source

OpenAIRE

Egea Chueca, Héctor

2011-01-01

En este proyecto fin de carrera se comprueba en qué medida una solución de router open-source, puede sustituir a routers CISCO en un entorno de laboratorio. Se podrá ver algunos de los servicios de los que dispone el sistema Vyatta en su versión gratuita, comprobando que puede realizar muchas de las funciones de los routers CISCO. Para ello, primero se hará una comparación de las diferentes opciones que existen a la hora de elegir un open-source routing, explicando qué es, cómo...

Mobile e-Learning for Next Generation Communication Environment

Science.gov (United States)

Wu, Tin-Yu; Chao, Han-Chieh

2008-01-01

This article develops an environment for mobile e-learning that includes an interactive course, virtual online labs, an interactive online test, and lab-exercise training platform on the fourth generation mobile communication system. The Next Generation Learning Environment (NeGL) promotes the term "knowledge economy." Inter-networking…

Domestic and foreign trends in the prevalence of heart failure and the necessity of next-generation artificial hearts: a survey by the Working Group on Establishment of Assessment Guidelines for Next-Generation Artificial Heart Systems.

Science.gov (United States)

Tatsumi, Eisuke; Nakatani, Takeshi; Imachi, Kou; Umezu, Mitsuo; Kyo, Shun-Ei; Sase, Kazuhiro; Takatani, Setsuo; Matsuda, Hikaru

2007-01-01

A series of guidelines for development and assessment of next-generation medical devices has been drafted under an interagency collaborative project by the Ministry of Health, Labor and Welfare and the Ministry of Economy, Trade and Industry. The working group for assessment guidelines of next-generation artificial hearts reviewed the trend in the prevalence of heart failure and examined the potential usefulness of such devices in Japan and in other countries as a fundamental part of the process of establishing appropriate guidelines. At present, more than 23 million people suffer from heart failure in developed countries, including Japan. Although Japan currently has the lowest mortality from heart failure among those countries, the number of patients is gradually increasing as our lifestyle becomes more Westernized; the associated medical expenses are rapidly growing. The number of heart transplantations, however, is limited due to the overwhelming shortage of donor hearts, not only in Japan but worldwide. Meanwhile, clinical studies and surveys have revealed that the major causes of death in patients undergoing long-term use of ventricular assist devices (VADs) were infection, thrombosis, and mechanical failure, all of which are typical of VADs. It is therefore of urgent and universal necessity to develop next-generation artificial hearts that have excellent durability to provide at least 2 years of event-free operation with a superior quality of life and that can be used for destination therapy to save patients with irreversible heart failure. It is also very important to ensure that an environment that facilitates the development, testing, and approval evaluation processes of next-generation artificial hearts be established as soon as possible.

A Window Into Clinical Next-Generation Sequencing-Based Oncology Testing Practices.

Science.gov (United States)

Nagarajan, Rakesh; Bartley, Angela N; Bridge, Julia A; Jennings, Lawrence J; Kamel-Reid, Suzanne; Kim, Annette; Lazar, Alexander J; Lindeman, Neal I; Moncur, Joel; Rai, Alex J; Routbort, Mark J; Vasalos, Patricia; Merker, Jason D

2017-12-01

- Detection of acquired variants in cancer is a paradigm of precision medicine, yet little has been reported about clinical laboratory practices across a broad range of laboratories. - To use College of American Pathologists proficiency testing survey results to report on the results from surveys on next-generation sequencing-based oncology testing practices. - College of American Pathologists proficiency testing survey results from more than 250 laboratories currently performing molecular oncology testing were used to determine laboratory trends in next-generation sequencing-based oncology testing. - These presented data provide key information about the number of laboratories that currently offer or are planning to offer next-generation sequencing-based oncology testing. Furthermore, we present data from 60 laboratories performing next-generation sequencing-based oncology testing regarding specimen requirements and assay characteristics. The findings indicate that most laboratories are performing tumor-only targeted sequencing to detect single-nucleotide variants and small insertions and deletions, using desktop sequencers and predesigned commercial kits. Despite these trends, a diversity of approaches to testing exists. - This information should be useful to further inform a variety of topics, including national discussions involving clinical laboratory quality systems, regulation and oversight of next-generation sequencing-based oncology testing, and precision oncology efforts in a data-driven manner.

Next-generation mammalian genetics toward organism-level systems biology.

Science.gov (United States)

Susaki, Etsuo A; Ukai, Hideki; Ueda, Hiroki R

2017-01-01

Organism-level systems biology in mammals aims to identify, analyze, control, and design molecular and cellular networks executing various biological functions in mammals. In particular, system-level identification and analysis of molecular and cellular networks can be accelerated by next-generation mammalian genetics. Mammalian genetics without crossing, where all production and phenotyping studies of genome-edited animals are completed within a single generation drastically reduce the time, space, and effort of conducting the systems research. Next-generation mammalian genetics is based on recent technological advancements in genome editing and developmental engineering. The process begins with introduction of double-strand breaks into genomic DNA by using site-specific endonucleases, which results in highly efficient genome editing in mammalian zygotes or embryonic stem cells. By using nuclease-mediated genome editing in zygotes, or ~100% embryonic stem cell-derived mouse technology, whole-body knock-out and knock-in mice can be produced within a single generation. These emerging technologies allow us to produce multiple knock-out or knock-in strains in high-throughput manner. In this review, we discuss the basic concepts and related technologies as well as current challenges and future opportunities for next-generation mammalian genetics in organism-level systems biology.

Towards Next Generation BI Systems

DEFF Research Database (Denmark)

Varga, Jovan; Romero, Oscar; Pedersen, Torben Bach

2014-01-01

Next generation Business Intelligence (BI) systems require integration of heterogeneous data sources and a strong user-centric orientation. Both needs entail machine-processable metadata to enable automation and allow end users to gain access to relevant data for their decision making processes....... This framework is based on the findings of a survey of current user-centric approaches mainly focusing on query recommendation assistance. Finally, we discuss the benefits of the framework and present the plans for future work....

Data Analysis and Next Generation Assessments

Science.gov (United States)

Pon, Kathy

2013-01-01

For the last decade, much of the work of California school administrators has been shaped by the accountability of the No Child Left Behind Act. Now as they stand at the precipice of Common Core Standards and next generation assessments, it is important to reflect on the proficiency educators have attained in using data to improve instruction and…

Achieving universal access to next generation networks

DEFF Research Database (Denmark)

Falch, Morten; Henten, Anders

The paper examines investment dimensions of next generation networks in a universal service perspective in a European context. The question is how new network infrastructures for getting access to communication, information and entertainment services in the present and future information society...

Next generation breeding.

Science.gov (United States)

Barabaschi, Delfina; Tondelli, Alessandro; Desiderio, Francesca; Volante, Andrea; Vaccino, Patrizia; Valè, Giampiero; Cattivelli, Luigi

2016-01-01

The genomic revolution of the past decade has greatly improved our understanding of the genetic make-up of living organisms. The sequencing of crop genomes has completely changed our vision and interpretation of genome organization and evolution. Re-sequencing allows the identification of an unlimited number of markers as well as the analysis of germplasm allelic diversity based on allele mining approaches. High throughput marker technologies coupled with advanced phenotyping platforms provide new opportunities for discovering marker-trait associations which can sustain genomic-assisted breeding. The availability of genome sequencing information is enabling genome editing (site-specific mutagenesis), to obtain gene sequences desired by breeders. This review illustrates how next generation sequencing-derived information can be used to tailor genomic tools for different breeders' needs to revolutionize crop improvement. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Next-Generation Sequencing: From Understanding Biology to Personalized Medicine

Directory of Open Access Journals (Sweden)

Benjamin Meder

2013-03-01

Full Text Available Within just a few years, the new methods for high-throughput next-generation sequencing have generated completely novel insights into the heritability and pathophysiology of human disease. In this review, we wish to highlight the benefits of the current state-of-the-art sequencing technologies for genetic and epigenetic research. We illustrate how these technologies help to constantly improve our understanding of genetic mechanisms in biological systems and summarize the progress made so far. This can be exemplified by the case of heritable heart muscle diseases, so-called cardiomyopathies. Here, next-generation sequencing is able to identify novel disease genes, and first clinical applications demonstrate the successful translation of this technology into personalized patient care.

Next Generation Drivetrain Development and Test Program

Energy Technology Data Exchange (ETDEWEB)

Keller, Jonathan; Erdman, Bill; Blodgett, Doug; Halse, Chris; Grider, Dave

2015-11-03

This presentation was given at the Wind Energy IQ conference in Bremen, Germany, November 30 through December 2, 2105. It focused on the next-generation drivetrain architecture and drivetrain technology development and testing (including gearbox and inverter software and medium-voltage inverter modules.

Heterogeneous next-generation wireless network interference model-and its applications

KAUST Repository

Mahmood, Nurul Huda

2014-04-01

Next-generation wireless systems facilitating better utilisation of the scarce radio spectrum have emerged as a response to inefficient and rigid spectrum assignment policies. These are comprised of intelligent radio nodes that opportunistically operate in the radio spectrum of existing primary systems, yet unwanted interference at the primary receivers is unavoidable. In order to design efficient next-generation systems and to minimise the adverse effect of their interference, it is necessary to realise how the resulting interference impacts the performance of the primary systems. In this work, a generalised framework for the interference analysis of such a next-generation system is presented where the nextgeneration transmitters may transmit randomly with different transmit powers. The analysis is built around a model developed for the statistical representation of the interference at the primary receivers, which is then used to evaluate various performance measures of the primary system. Applications of the derived interference model in designing the next-generation network system parameters are also demonstrated. Such approach provides a unified and generalised framework, the use of which allows a wide range of performance metrics can be evaluated. Findings of the analytical performance analyses are confirmed through extensive computer-based Monte-Carlo simulations. © 2012 John Wiley & Sons, Ltd.

Study of Coregonus Populations in the Zone of Intergradation between the Vendace and Least Cisco: the Role of the Environment in Speciation

Directory of Open Access Journals (Sweden)

Borovikova Elena

2012-12-01

Full Text Available Phylogenetic analysis using mitochondrial and nuclear DNA markers showed that the Least Cisco gradually spread from Siberia to Europe until the last glaciation. This was accompanied by gradual replacement of "typically Siberian" gene variants with "typically European" ones. Morphological traits also changed as the species expanded, the changes in the body proportions being apparently adaptive. They are likely to reflect the transition of the cisco from the semi-anadromous life history type to the lacustrine type, which is more characteristic of the European form. Thus, the speciation of the vendace is clearly adaptive, at least with respect to some traits. It should be noted, however, that the results of this study raise doubt as to whether the vendace has entirely diverged from the Least Cisco, and the speciation has completed.

76 FR 49776 - The Development and Evaluation of Next-Generation Smallpox Vaccines; Public Workshop

Science.gov (United States)

2011-08-11

...] The Development and Evaluation of Next-Generation Smallpox Vaccines; Public Workshop AGENCY: Food and... Evaluation of Next-Generation Smallpox Vaccines.'' The purpose of the public workshop is to identify and discuss the key issues related to the development and evaluation of next-generation smallpox vaccines. The...

Applications of nanotechnology, next generation sequencing and microarrays in biomedical research.

Science.gov (United States)

Elingaramil, Sauli; Li, Xiaolong; He, Nongyue

2013-07-01

Next-generation sequencing technologies, microarrays and advances in bio nanotechnology have had an enormous impact on research within a short time frame. This impact appears certain to increase further as many biomedical institutions are now acquiring these prevailing new technologies. Beyond conventional sampling of genome content, wide-ranging applications are rapidly evolving for next-generation sequencing, microarrays and nanotechnology. To date, these technologies have been applied in a variety of contexts, including whole-genome sequencing, targeted re sequencing and discovery of transcription factor binding sites, noncoding RNA expression profiling and molecular diagnostics. This paper thus discusses current applications of nanotechnology, next-generation sequencing technologies and microarrays in biomedical research and highlights the transforming potential these technologies offer.

How systematic age underestimation can impede understanding of fish population dynamics: Lessons learned from a Lake Superior cisco stock

Science.gov (United States)

Yule, D.L.; Stockwell, J.D.; Black, J.A.; Cullis, K.I.; Cholwek, G.A.; Myers, J.T.

2008-01-01

Systematic underestimation of fish age can impede understanding of recruitment variability and adaptive strategies (like longevity) and can bias estimates of survivorship. We suspected that previous estimates of annual survival (S; range = 0.20-0.44) for Lake Superior ciscoes Coregonus artedi developed from scale ages were biased low. To test this hypothesis, we estimated the total instantaneous mortality rate of adult ciscoes from the Thunder Bay, Ontario, stock by use of cohort-based catch curves developed from commercial gill-net catches and otolith-aged fish. Mean S based on otolith ages was greater for adult females (0.80) than for adult males (0.75), but these differences were not significant. Applying the results of a study of agreement between scale and otolith ages, we modeled a scale age for each otolith-aged fish to reconstruct catch curves. Using modeled scale ages, estimates of S (0.42 for females, 0.36 for males) were comparable with those reported in past studies. We conducted a November 2005 acoustic and midwater trawl survey to estimate the abundance of ciscoes when the fish were being harvested for roe. Estimated exploitation rates were 0.085 for females and 0.025 for males, and the instantaneous rates of fishing mortality were 0.089 for females and 0.025 for males. The instantaneous rates of natural mortality were 0.131 and 0.265 for females and males, respectively. Using otolith ages, we found that strong year-classes at large during November 2005 were caught in high numbers as age-1 fish in previous annual bottom trawl surveys, whereas weak or absent year-classes were not. For decades, large-scale fisheries on the Great Lakes were allowed to operate because ciscoes were assumed to be short lived and to have regular recruitment. We postulate that the collapse of these fisheries was linked in part to a misunderstanding of cisco biology driven by scale-ageing error. ?? Copyright by the American Fisheries Society 2008.

Next generation surveillance system (NGSS)

International Nuclear Information System (INIS)

Aparo, Massimo

2006-01-01

Development of 'functional requirements' for transparency systems may offer a near-term mode of regional cooperation. New requirements under development at the IAEA may provide a foundation for this potential activity. The Next Generation Surveillance System (NGSS) will become the new IAEA remote monitoring system Under new requirements the NGSS would attempt to use more commercial components to reduce cost, increase radiation survivability and further increase reliability. The NGSS must be available in two years due to rapidly approaching obsolescence in the existing DCM family. (author)

Optimizing the next generation optical access networks

DEFF Research Database (Denmark)

Amaya Fernández, Ferney Orlando; Soto, Ana Cardenas; Tafur Monroy, Idelfonso

2009-01-01

Several issues in the design and optimization of the next generation optical access network (NG-OAN) are presented. The noise, the distortion and the fiber optic nonlinearities are considered to optimize the video distribution link in a passive optical network (PON). A discussion of the effect...

IPv6: The Next Generation Internet Protocol

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 3. IPv6: The Next Generation Internet Protocol - IPv4 and its Shortcomings. Harsha Srinath. General Article Volume 8 Issue 3 March 2003 pp 33-41. Fulltext. Click here to view fulltext PDF. Permanent link:

IPv6: The Next Generation Internet Protocol

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 4. IPv6: The Next Generation Internet Protocol - New Features in IPv6. Harsha Srinath. General Article Volume 8 Issue 4 April 2003 pp 8-16. Fulltext. Click here to view fulltext PDF. Permanent link:

Next-Generation Sequencing for Binary Protein-Protein Interactions

Directory of Open Access Journals (Sweden)

Bernhard eSuter

2015-12-01

Full Text Available The yeast two-hybrid (Y2H system exploits host cell genetics in order to display binary protein-protein interactions (PPIs via defined and selectable phenotypes. Numerous improvements have been made to this method, adapting the screening principle for diverse applications, including drug discovery and the scale-up for proteome wide interaction screens in human and other organisms. Here we discuss a systematic workflow and analysis scheme for screening data generated by Y2H and related assays that includes high-throughput selection procedures, readout of comprehensive results via next-generation sequencing (NGS, and the interpretation of interaction data via quantitative statistics. The novel assays and tools will serve the broader scientific community to harness the power of NGS technology to address PPI networks in health and disease. We discuss examples of how this next-generation platform can be applied to address specific questions in diverse fields of biology and medicine.

Next Generation Safeguards Initiative: Human Capital Development

International Nuclear Information System (INIS)

Scholz, M.; Irola, G.; Glynn, K.

2015-01-01

Since 2008, the Human Capital Development (HCD) subprogramme of the U.S. National Nuclear Security Administration's (NNSA) Next Generation Safeguards Initiative (NGSI) has supported the recruitment, education, training, and retention of the next generation of international safeguards professionals to meet the needs of both the International Atomic Energy Agency (IAEA) and the United States. Specifically, HCD's efforts respond to data indicating that 82% of safeguards experts at U.S. Laboratories will have left the workforce within 15 years. This paper provides an update on the status of the subprogramme since its last presentation at the IAEA Safeguards Symposium in 2010. It highlights strengthened, integrated efforts in the areas of graduate and post-doctoral fellowships, young and midcareer professional support, short safeguards courses, and university engagement. It also discusses lessons learned from the U.S. experience in safeguards education and training as well as the importance of long-range strategies to develop a cohesive, effective, and efficient human capital development approach. (author)

Next Generation Sequencing of Ancient DNA: Requirements, Strategies and Perspectives

Directory of Open Access Journals (Sweden)

Michael Knapp

2010-07-01

Full Text Available The invention of next-generation-sequencing has revolutionized almost all fields of genetics, but few have profited from it as much as the field of ancient DNA research. From its beginnings as an interesting but rather marginal discipline, ancient DNA research is now on its way into the centre of evolutionary biology. In less than a year from its invention next-generation-sequencing had increased the amount of DNA sequence data available from extinct organisms by several orders of magnitude. Ancient DNA  research is now not only adding a temporal aspect to evolutionary studies and allowing for the observation of evolution in real time, it also provides important data to help understand the origins of our own species. Here we review progress that has been made in next-generation-sequencing of ancient DNA over the past five years and evaluate sequencing strategies and future directions.

NOAA Next Generation Radar (NEXRAD) Level 3 Products

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This dataset consists of Level 3 weather radar products collected from Next-Generation Radar (NEXRAD) stations located in the contiguous United States, Alaska,...

The Matrix Element Method at Next-to-Leading Order

OpenAIRE

Campbell, John M.; Giele, Walter T.; Williams, Ciaran

2012-01-01

This paper presents an extension of the matrix element method to next-to-leading order in perturbation theory. To accomplish this we have developed a method to calculate next-to-leading order weights on an event-by-event basis. This allows for the definition of next-to-leading order likelihoods in exactly the same fashion as at leading order, thus extending the matrix element method to next-to-leading order. A welcome by-product of the method is the straightforward and efficient generation of...

Next generation sensors and systems

CERN Document Server

2016-01-01

Written by experts in their area of research, this book has outlined the current status of the fundamentals and analytical concepts, modelling and design issues, technical details and practical applications of different types of sensors and discussed about the trends of next generation of sensors and systems happening in the area of Sensing technology. This book will be useful as a reference book for engineers and scientist especially the post-graduate students find will this book as reference book for their research on wearable sensors, devices and technologies.  .

Diagnostics of Primary Immunodeficiencies through Next Generation Sequencing

Directory of Open Access Journals (Sweden)

Vera Gallo

2016-11-01

Full Text Available Background: Recently, a growing number of novel genetic defects underlying primary immunodeficiencies (PID have been identified, increasing the number of PID up to more than 250 well-defined forms. Next-generation sequencing (NGS technologies and proper filtering strategies greatly contributed to this rapid evolution, providing the possibility to rapidly and simultaneously analyze large numbers of genes or the whole exome. Objective: To evaluate the role of targeted next-generation sequencing and whole exome sequencing in the diagnosis of a case series, characterized by complex or atypical clinical features suggesting a PID, difficult to diagnose using the current diagnostic procedures.Methods: We retrospectively analyzed genetic variants identified through targeted next-generation sequencing or whole exome sequencing in 45 patients with complex PID of unknown etiology. Results: 40 variants were identified using targeted next-generation sequencing, while 5 were identified using whole exome sequencing. Newly identified genetic variants were classified into 4 groups: I variations associated with a well-defined PID; II variations associated with atypical features of a well-defined PID; III functionally relevant variations potentially involved in the immunological features; IV non-diagnostic genotype, in whom the link with phenotype is missing. We reached a conclusive genetic diagnosis in 7/45 patients (~16%. Among them, 4 patients presented with a typical well-defined PID. In the remaining 3 cases, mutations were associated with unexpected clinical features, expanding the phenotypic spectrum of typical PIDs. In addition, we identified 31 variants in 10 patients with complex phenotype, individually not causative per se of the disorder.Conclusion: NGS technologies represent a cost-effective and rapid first-line genetic approaches for the evaluation of complex PIDs. Whole exome sequencing, despite a moderate higher cost compared to targeted, is

Examination of concept of next generation computer. Progress report 1999

Energy Technology Data Exchange (ETDEWEB)

Higuchi, Kenji; Hasegawa, Yukihiro; Hirayama, Toshio

2000-12-01

The Center for Promotion of Computational Science and Engineering has conducted R and D works on the technology of parallel processing and has started the examination of the next generation computer in 1999. This report describes the behavior analyses of quantum calculation codes. It also describes the consideration for the analyses and examination results for the method to reduce cash misses. Furthermore, it describes a performance simulator that is being developed to quantitatively examine the concept of the next generation computer. (author)

Next-Generation Pathology.

Science.gov (United States)

Caie, Peter D; Harrison, David J

2016-01-01

The field of pathology is rapidly transforming from a semiquantitative and empirical science toward a big data discipline. Large data sets from across multiple omics fields may now be extracted from a patient's tissue sample. Tissue is, however, complex, heterogeneous, and prone to artifact. A reductionist view of tissue and disease progression, which does not take this complexity into account, may lead to single biomarkers failing in clinical trials. The integration of standardized multi-omics big data and the retention of valuable information on spatial heterogeneity are imperative to model complex disease mechanisms. Mathematical modeling through systems pathology approaches is the ideal medium to distill the significant information from these large, multi-parametric, and hierarchical data sets. Systems pathology may also predict the dynamical response of disease progression or response to therapy regimens from a static tissue sample. Next-generation pathology will incorporate big data with systems medicine in order to personalize clinical practice for both prognostic and predictive patient care.

Potential of OFDM for next generation optical access

Science.gov (United States)

Fritzsche, Daniel; Weis, Erik; Breuer, Dirk

2011-01-01

This paper shows the requirements for next generation optical access (NGOA) networks and analyzes the potential of OFDM (orthogonal frequency division multiplexing) for the use in such network scenarios. First, we show the motivation for NGOA systems based on the future requirements on FTTH access systems and list the advantages of OFDM in such scenarios. In the next part, the basics of OFDM and different methods to generate and detect optical OFDM signals are explained and analyzed. At the transmitter side the options include intensity modulation and the more advanced field modulation of the optical OFDM signal. At the receiver there is the choice between direct detection and coherent detection. As the result of this discussion we show our vision of the future use of OFDM in optical access networks.

Neutronics activities for next generation devices

International Nuclear Information System (INIS)

Gohar, Y.

1985-01-01

Neutronic activities for the next generation devices are the subject of this paper. The main activities include TFCX and FPD blanket/shield studies, neutronic aspects of ETR/INTOR critical issues, and neutronics computational modules for the tokamak system code and tandem mirror reactor system code. Trade-off analyses, optimization studies, design problem investigations and computational models development for reactor parametric studies carried out for these activities are summarized

THE TRAINING OF NEXT GENERATION DATA SCIENTISTS IN BIOMEDICINE.

Science.gov (United States)

Garmire, Lana X; Gliske, Stephen; Nguyen, Quynh C; Chen, Jonathan H; Nemati, Shamim; VAN Horn, John D; Moore, Jason H; Shreffler, Carol; Dunn, Michelle

2017-01-01

With the booming of new technologies, biomedical science has transformed into digitalized, data intensive science. Massive amount of data need to be analyzed and interpreted, demand a complete pipeline to train next generation data scientists. To meet this need, the transinstitutional Big Data to Knowledge (BD2K) Initiative has been implemented since 2014, complementing other NIH institutional efforts. In this report, we give an overview the BD2K K01 mentored scientist career awards, which have demonstrated early success. We address the specific trainings needed in representative data science areas, in order to make the next generation of data scientists in biomedicine.

A two-stage flow-based intrusion detection model for next-generation networks.

Science.gov (United States)

Umer, Muhammad Fahad; Sher, Muhammad; Bi, Yaxin

2018-01-01

The next-generation network provides state-of-the-art access-independent services over converged mobile and fixed networks. Security in the converged network environment is a major challenge. Traditional packet and protocol-based intrusion detection techniques cannot be used in next-generation networks due to slow throughput, low accuracy and their inability to inspect encrypted payload. An alternative solution for protection of next-generation networks is to use network flow records for detection of malicious activity in the network traffic. The network flow records are independent of access networks and user applications. In this paper, we propose a two-stage flow-based intrusion detection system for next-generation networks. The first stage uses an enhanced unsupervised one-class support vector machine which separates malicious flows from normal network traffic. The second stage uses a self-organizing map which automatically groups malicious flows into different alert clusters. We validated the proposed approach on two flow-based datasets and obtained promising results.

Radio resource management for next generation mobile communication systems

DEFF Research Database (Denmark)

Wang, Hua

The key feature of next generation (4G) mobile communication system is the ability to deliver a variety of multimedia services with different Quality-of-Service (QoS) requirements. Compared to the third generation (3G) mobile communication systems, 4G mobile communication system introduces several...

Energy and luminosity requirements for the next generation of linear colliders

International Nuclear Information System (INIS)

Amaldi, U.

1987-01-01

In order to gain new knowledge ('new physics') from 'next generation' linear colliders energy and luminosity are important variables when considering the design of these new elementary particle probes. The standard model of the electroweak interaction is reviewed and stipulations for postulated Higgs particle, a new neutral Z particle, and a new quark and a neutral lepton searches with next generation colliders are given

Dependable Hydrogen and Industrial Heat Generation from the Next Generation Nuclear Plant

Energy Technology Data Exchange (ETDEWEB)

Charles V. Park; Michael W. Patterson; Vincent C. Maio; Piyush Sabharwall

2009-03-01

The Department of Energy is working with industry to develop a next generation, high-temperature gas-cooled nuclear reactor (HTGR) as a part of the effort to supply the US with abundant, clean and secure energy. The Next Generation Nuclear Plant (NGNP) project, led by the Idaho National Laboratory, will demonstrate the ability of the HTGR to generate hydrogen, electricity, and high-quality process heat for a wide range of industrial applications. Substituting HTGR power for traditional fossil fuel resources reduces the cost and supply vulnerability of natural gas and oil, and reduces or eliminates greenhouse gas emissions. As authorized by the Energy Policy Act of 2005, industry leaders are developing designs for the construction of a commercial prototype producing up to 600 MWt of power by 2021. This paper describes a variety of critical applications that are appropriate for the HTGR with an emphasis placed on applications requiring a clean and reliable source of hydrogen. An overview of the NGNP project status and its significant technology development efforts are also presented.

Perspectives on the development of next generation reactor systems safety analysis codes

International Nuclear Information System (INIS)

Zhang, H.

2015-01-01

'Full text:' Existing reactor system analysis codes, such as RELAP5-3D and TRAC, have gained worldwide success in supporting reactor safety analyses, as well as design and licensing of new reactors. These codes are important assets to the nuclear engineering research community, as well as to the nuclear industry. However, most of these codes were originally developed during the 1970s', and it becomes necessary to develop next-generation reactor system analysis codes for several reasons. Firstly, as new reactor designs emerge, there are new challenges emerging in numerical simulations of reactor systems such as long lasting transients and multi-physics phenomena. These new requirements are beyond the range of applicability of the existing system analysis codes. Advanced modeling and numerical methods must be taken into consideration to improve the existing capabilities. Secondly, by developing next-generation reactor system analysis codes, the knowledge (know how) in two phase flow modeling and the highly complex constitutive models will be transferred to the young generation of nuclear engineers. And thirdly, all computer codes have limited shelf life. It becomes less and less cost-effective to maintain a legacy code, due to the fast change of computer hardware and software environment. There are several critical perspectives in terms of developing next-generation reactor system analysis codes: 1) The success of the next-generation codes must be built upon the success of the existing codes. The knowledge of the existing codes, not just simply the manuals and codes, but knowing why and how, must be transferred to the next-generation codes. The next-generation codes should encompass the capability of the existing codes. The shortcomings of existing codes should be identified, understood, and properly categorized, for example into model deficiencies or numerical method deficiencies. 2) State-of-the-art models and numerical methods must be considered to

Perspectives on the development of next generation reactor systems safety analysis codes

Energy Technology Data Exchange (ETDEWEB)

Zhang, H., E-mail: Hongbin.Zhang@inl.gov [Idaho National Laboratory, Idaho Falls, ID (United States)

2015-07-01

'Full text:' Existing reactor system analysis codes, such as RELAP5-3D and TRAC, have gained worldwide success in supporting reactor safety analyses, as well as design and licensing of new reactors. These codes are important assets to the nuclear engineering research community, as well as to the nuclear industry. However, most of these codes were originally developed during the 1970s', and it becomes necessary to develop next-generation reactor system analysis codes for several reasons. Firstly, as new reactor designs emerge, there are new challenges emerging in numerical simulations of reactor systems such as long lasting transients and multi-physics phenomena. These new requirements are beyond the range of applicability of the existing system analysis codes. Advanced modeling and numerical methods must be taken into consideration to improve the existing capabilities. Secondly, by developing next-generation reactor system analysis codes, the knowledge (know how) in two phase flow modeling and the highly complex constitutive models will be transferred to the young generation of nuclear engineers. And thirdly, all computer codes have limited shelf life. It becomes less and less cost-effective to maintain a legacy code, due to the fast change of computer hardware and software environment. There are several critical perspectives in terms of developing next-generation reactor system analysis codes: 1) The success of the next-generation codes must be built upon the success of the existing codes. The knowledge of the existing codes, not just simply the manuals and codes, but knowing why and how, must be transferred to the next-generation codes. The next-generation codes should encompass the capability of the existing codes. The shortcomings of existing codes should be identified, understood, and properly categorized, for example into model deficiencies or numerical method deficiencies. 2) State-of-the-art models and numerical methods must be considered to

Synchronization System for Next Generation Light Sources

Energy Technology Data Exchange (ETDEWEB)

Zavriyev, Anton [MagiQ Technologies, Inc., Somerville, MA (United States)

2014-03-27

An alternative synchronization technique – one that would allow explicit control of the pulse train including its repetition rate and delay is clearly desired. We propose such a scheme. Our method is based on optical interferometry and permits synchronization of the pulse trains generated by two independent mode-locked lasers. As the next generation x-ray sources will be driven by a clock signal derived from a mode-locked optical source, our technique will provide a way to synchronize x-ray probe with the optical pump pulses.

Mobility Models for Next Generation Wireless Networks Ad Hoc, Vehicular and Mesh Networks

CERN Document Server

Santi, Paolo

2012-01-01

Mobility Models for Next Generation Wireless Networks: Ad Hoc, Vehicular and Mesh Networks provides the reader with an overview of mobility modelling, encompassing both theoretical and practical aspects related to the challenging mobility modelling task. It also: Provides up-to-date coverage of mobility models for next generation wireless networksOffers an in-depth discussion of the most representative mobility models for major next generation wireless network application scenarios, including WLAN/mesh networks, vehicular networks, wireless sensor networks, and

CISCO SYSTEM’S STRATEGIC USE OF THE INTERNET AND BUSINESS APPLICATIONS

OpenAIRE

Abdurrahman Celebi; Raju Vijaya

2011-01-01

Information systems are the key decision component of a firm’s business strategy. Cisco made use of internet and its information systems to accomplish its following strategies: to create a business ecology market its technology to networking world; to create a virtual organization and outsourcing many operational and customer services and focusing its resources on its own core product innovation strategy; to showcase its own internet use as a marketing tool. Cisco’s strategy enabl...

Next Generation Sequencing of Tubal Intraepithelial Carcinomas

Science.gov (United States)

McDaniel, Andrew S.; Stall, Jennifer N.; Hovelson, Daniel H.; Cani, Andi K.; Liu, Chia-Jen; Tomlins, Scott A.; Cho, Kathleen R.

2016-01-01

Importance High-grade serous carcinoma (HGSC) is the most prevalent and lethal form of ovarian cancer. HGSCs frequently arise in the distal fallopian tubes rather than the ovary, developing from small precursor lesions called serous tubal intraepithelial carcinomas (TICs or more specifically STICs). While STICs have been reported to harbor TP53 mutations, detailed molecular characterizations of these lesions are lacking. Observations We performed targeted next generation sequencing (NGS) on formalin-fixed, paraffin- embedded tissue from four women, two with HGSC and two with uterine endometrioid carcinoma (UEC) who were diagnosed with synchronous STICs. We detected concordant mutations in both HGSCs with synchronous STICs, including TP53 mutations as well as assumed germline BRCA1/2 alterations, confirming a clonal relationship between these lesions. NGS confirmed the presence of a STIC clonally unrelated to one case of UEC. NGS of the other tubal lesion diagnosed as a STIC unexpectedly supported the lesion as a micrometastasis from the associated UEC. Conclusions and Relevance We demonstrate that targeted NGS can identify genetic lesions in minute lesions such as TICs, and confirm TP53 mutations as early driving events for HGSC. NGS also demonstrated unexpected relationships between presumed STICs and synchronous carcinomas, suggesting potential diagnostic and translational research applications. PMID:26181193

Can pelagic forage fish and spawning cisco (Coregonus artedi) biomass in the western arm of Lake Superior be assessed with a single summer survey?

Science.gov (United States)

Yule, D.L.; Stockwell, J.D.; Schreiner, D.R.; Evrard, L.M.; Balge, M.; Hrabik, T.R.

2009-01-01

Management efforts to rehabilitate lake trout Salvelinus namaycush in Lake Superior have been successful and the recent increase in their numbers has led to interest in measuring biomass of pelagic prey fish species important to these predators. Lake Superior cisco Coregonus artedi currently support roe fisheries and determining the sustainability of these fisheries is an important management issue. We conducted acoustic and midwater trawl surveys of the western arm of Lake Superior during three periods: summer (July-August), October, and November 2006 to determine if a single survey can be timed to estimate biomass of both prey fish and spawning cisco. We evaluated our methods by comparing observed trawl catches of small (cisco increased substantially in November, while small bloater Coregonus hoyi biomass was lower. We compared our summer 2006 estimates of total fish biomass to the results of a summer survey in 1997 and obtained similar results. We conclude that the temporal window for obtaining biomass estimates of pelagic prey species in the western arm of Lake Superior is wide (July through October), but estimating spawning cisco abundance is best done with a November survey.

Precision medicine for cancer with next-generation functional diagnostics.

Science.gov (United States)

Friedman, Adam A; Letai, Anthony; Fisher, David E; Flaherty, Keith T

2015-12-01

Precision medicine is about matching the right drugs to the right patients. Although this approach is technology agnostic, in cancer there is a tendency to make precision medicine synonymous with genomics. However, genome-based cancer therapeutic matching is limited by incomplete biological understanding of the relationship between phenotype and cancer genotype. This limitation can be addressed by functional testing of live patient tumour cells exposed to potential therapies. Recently, several 'next-generation' functional diagnostic technologies have been reported, including novel methods for tumour manipulation, molecularly precise assays of tumour responses and device-based in situ approaches; these address the limitations of the older generation of chemosensitivity tests. The promise of these new technologies suggests a future diagnostic strategy that integrates functional testing with next-generation sequencing and immunoprofiling to precisely match combination therapies to individual cancer patients.

User-Generated Social Media Events in Tourism

OpenAIRE

Mariné Roig, Estela; Martín Fuentes, Eva; Daries Ramón, Natalia

2017-01-01

Social media and mobile technologies have revolutionised communication and particular attention has been given to user-generated content (UGC) and the formation of online communities; however, little attention has been given to tourist events entirely generated by users through social media. This paper aims to define and characterise the phenomenon of tourism user-generated events (UGEs) through social media around the user's new empowered role and to assess user-generated social media events...

Next-generation storm tracking for minimizing service interruption

Energy Technology Data Exchange (ETDEWEB)

Sznaider, R. [Meteorlogix, Minneapolis, MN (United States)

2002-08-01

Several technological changes have taken place in the field of weather radar since its discovery during World War II. A wide variety of industries have benefited over the years from conventional weather radar displays, providing assistance in forecasting and estimating the potential severity of storms. The characteristics of individual storm cells can now be derived from the next-generation of weather radar systems (NEXRAD). The determination of which storm cells possess distinct features such as large hail or developing tornadoes was made possible through the fusing of various pieces of information with radar pictures. To exactly determine when and where a storm will hit, this data can be combined and overlaid into a display that includes the geographical physical landmarks of a specific region. Combining Geographic Information Systems (GIS) and storm tracking provides a more complete, timely and accurate forecast, which clearly benefits the electric utilities industries. The generation and production of energy are dependent on how hot or cold it will be today and tomorrow. The author described each major feature of this next-generation weather radar system. 9 figs.

Educating the next generation of nature entrepreneurs

Science.gov (United States)

Judith C. Jobse; Loes Witteveen; Judith Santegoets; Daan van der Linde

2015-01-01

With this paper, it is illustrated that a focus on entrepreneurship training in the nature and wilderness sector is relevant for diverse organisations and situations. The first curricula on nature entrepreneurship are currently being developed. In this paper the authors describe a project that focusses on educating the next generation of nature entrepreneurs, reflect...

How Cisco Systems Used Enterprise Architecture Capability to Sustain Acquisition-Based Growth

DEFF Research Database (Denmark)

Toppenberg, Gustav; Shanks, Graeme; Henningsson, Stefan

2015-01-01

Value-creating acquisitions are a major challenge for many firms. The case of Cisco Systems shows that an advanced enterprise architecture (EA) capability can contribute to the four phases of the acquisition process: pre-acquisition preparation, acquisition selection, acquisition integration...... and post-integration management. Cisco’s EA capability improves its ability to rapidly capture value from acquisitions and to sustain its acquisition-based growth strategy over time....

The Next Generation: Students Discuss Archaeology in the 21st Century

OpenAIRE

Sands, Ashley; Butler, Kristin

2010-01-01

The Next Generation Project is a multi-agent, multi-directional cultural diplomacy effort. The need for communication among emerging archaeologists has never been greater. Increasingly, archaeological sites are impacted by military activity, destroyed through the development of dams and building projects, and torn apart through looting. The Next Generation Project works to develop communication via social networking sites online and through in-person meetings at international conferences. As ...

NIRS report of investigations for the development of the next generation PET apparatus. FY 2000

International Nuclear Information System (INIS)

2001-03-01

This is a summary of study reports from representative technology fields for the development of the next generation PET apparatus directing to 3-D images, and is hoped to be useful for future smooth cooperation between the fields. The investigation started from April 2000 in National Institute of Radiological Sciences (NIRS) with cooperation of other facilities, universities and companies. The report involves chapters of: Detector volume and geometrical efficiency- Design criterion for the next generation PET; Scintillator for PET; An investigation of detector and front-end electronics for the next generation PET; A measurement system of depth of interaction; Detector simulator; Development of an evaluation system for PET detector; On the signal processing system for the next generation PET; List-mode data acquisition method for the next generation PET; List-mode data acquisition simulator; Image reconstruction; A Monte Carlo simulator for the next generation PET scanners; Out-of-field of view (FOV) radioactivity; and Published papers and presentations. (N.I.)

The next generation of power reactors - safety characteristics

International Nuclear Information System (INIS)

Modro, S.M.

1995-01-01

The next generation of commercial nuclear power reactors is characterized by a new approach to achieving reliability of their safety systems. In contrast to current generation reactors, these designs apply passive safety features that rely on gravity-driven transfer processes or stored energy, such as gas-pressurized accumulators or electric batteries. This paper discusses the passive safety system of the AP600 and Simplified Boiling Water Reactor (SBWR) designs

Wroclaw neutrino event generator

International Nuclear Information System (INIS)

Nowak, J A

2006-01-01

A neutrino event generator developed by the Wroclaw Neutrino Group is described. The physical models included in the generator are discussed and illustrated with the results of simulations. The considered processes are quasi-elastic scattering and pion production modelled by combining the Δ resonance excitation and deep inelastic scattering

Next-generation probabilistic seismicity forecasting

Energy Technology Data Exchange (ETDEWEB)

Hiemer, S.

2014-07-01

novel automated method to investigate the significance of spatial b-value variations. The method incorporates an objective data-driven partitioning scheme, which is based on penalized likelihood estimates. These well-defined criteria avoid the difficult choice of commonly applied spatial mapping parameters, such as grid spacing or size of mapping radii. We construct a seismicity forecast that includes spatial b-value variations and demonstrate our model’s skill and reliability when applied to data from California. All proposed probabilistic seismicity forecasts were subjected to evaluation methods using state of the art algorithms provided by the 'Collaboratory for the Study of Earthquake Predictability' infrastructure. First, we evaluated the statistical agreement between the forecasted and observed rates of target events in terms of number, space and magnitude. Secondly, we assessed the performance of one forecast relative to another. We find that the forecasts presented in this thesis are reliable and show significant skills with respect to established classical forecasts. These next-generation probabilistic seismicity forecasts can thus provide hazard information that are potentially useful in reducing earthquake losses and enhancing community preparedness and resilience. (author)

Next-generation probabilistic seismicity forecasting

International Nuclear Information System (INIS)

Hiemer, S.

2014-01-01

novel automated method to investigate the significance of spatial b-value variations. The method incorporates an objective data-driven partitioning scheme, which is based on penalized likelihood estimates. These well-defined criteria avoid the difficult choice of commonly applied spatial mapping parameters, such as grid spacing or size of mapping radii. We construct a seismicity forecast that includes spatial b-value variations and demonstrate our model’s skill and reliability when applied to data from California. All proposed probabilistic seismicity forecasts were subjected to evaluation methods using state of the art algorithms provided by the 'Collaboratory for the Study of Earthquake Predictability' infrastructure. First, we evaluated the statistical agreement between the forecasted and observed rates of target events in terms of number, space and magnitude. Secondly, we assessed the performance of one forecast relative to another. We find that the forecasts presented in this thesis are reliable and show significant skills with respect to established classical forecasts. These next-generation probabilistic seismicity forecasts can thus provide hazard information that are potentially useful in reducing earthquake losses and enhancing community preparedness and resilience. (author)

Next generation solar energy. From fundamentals to applications

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-07-01

Within the International Conference between 12th and 14th December, 2011 in Erlangen (Federal Republic of Germany) the following lectures were presented: (1) The opto-electronic physics required to approach the Shockley-Queisser efficiency limit (E. Yablonovitch); (2) The Shockley-Queisser-limit and beyond (G.H. Bauer); (3) Designing composite nanomaterials for photovoltaic devices (B. Rech); (4) Light-Material interactions in energy conversion (H. Atwater); (5) Functional imaging of hybrid nanostructures - Visualizing mechanisms of solar energy utilization (L. Lauhon); (6) Are photosynthetic proteins suitable for PV applications (Y. Rosenwaks); (7) Detailed balance limit in photovoltaic systems (U. Rau); (8) Plasmonics and nanophotonics for next generation photovoltaics (E. Garnett); (9) Dispersion, wave propagation and efficiency analysis of nanowire solar cells (B. Witzigmann); (10) Application of nanostructures to next generation photovoltaics - Opportunities and challenges from an industrial research perspective (L. Tsakalakos); (11) Triplet states in organic and organometallic photovoltaic cells (K.S. Schanze); (12) New photoelectrode architectures (J.T. Hupp); (13) Dendrimers for optoelectronic and photovoltaic applications (P. Ceroni); (14) Photon management with luminescent materials (J. Goldschmidt); (15) Economical aspects of next generation solar cell technologies (W. Hoffmann); (16) Scalability in solar energy conversion - First-row transition metal-based chromophores for dye-sensitized solar cells (J. McCusker); (17) Designing organic materials for photovoltaic devices (A. Harriman); (18) Molecular photovoltaics - What can we learn from model studies (B. Albinsson); (19) Porphyrin-sensitised titanium dioxide solar cells (D. Officer); (20) Light-harvesting: Charge separation, and charge-transportation properties of novel materials for organic photovoltaics (H. Imahori); (21) Phthalocyanines for molecular photovoltaics (T. Torres); (22) Photophysics of

Next Generation, Si-Compatible Materials and Devices in the Si-Ge-Sn System

Science.gov (United States)

2015-10-09

and conclusions The work initially focused on growth of next generation Ge1-ySny alloys on Ge buffered Si wafers via UHV CVD depositions of Ge3H8...Abstract The work initially focused on growth of next generation Ge1-ySny alloys on Ge buffered Si wafers via UHV CVD depositions of Ge3H8, SnD4. The...AFRL-AFOSR-VA-TR-2016-0044 Next generation, Si -compatible materials and devices in the Si - Ge -Sn system John Kouvetakis ARIZONA STATE UNIVERSITY Final

HLA typing: Conventional techniques v.next-generation sequencing

African Journals Online (AJOL)

The existing techniques have contributed significantly to our current knowledge of allelic diversity. At present, sequence-based typing (SBT) methods, in particular next-generation sequencing. (NGS), provide the highest possible resolution. NGS platforms were initially only used for genomic sequencing, but also showed.

EVENT GENERATOR FOR RHIC SPIN PHYSICS

International Nuclear Information System (INIS)

SAITO, N.; SCHAEFER, A.

1999-01-01

This volume archives the reports from the RIKEN BNL Research Center workshop on ''Event Generator for RHIC Spin Physics II'' held during the week March 15, 1999 at Brookhaven National Laboratory. It was the second meeting on the subject following a first one in last September. This workshop has been initiated to establish a firm collaboration between theorists and experimentalists involved in RHIC spin physics with the aim of developing a reliable, high-precision event generator for RHIC spin physics. Needless to say, adequate event generators are indispensable tools for high energy physics programs in general, especially in the process of: planning the experimental programs; developing algorithms to extract the physics signals of interest; estimating the background in the extracted results, and connecting the final particle kinematics to the fundamental i.e. partonic level processes. Since RHIC is the first polarized collider, dedicated efforts are required to obtain a full-fledged event generator which describes spin dependent reactions in great detail

Next-generation sequencing for endocrine cancers: Recent advances and challenges.

Science.gov (United States)

Suresh, Padmanaban S; Venkatesh, Thejaswini; Tsutsumi, Rie; Shetty, Abhishek

2017-05-01

Contemporary molecular biology research tools have enriched numerous areas of biomedical research that address challenging diseases, including endocrine cancers (pituitary, thyroid, parathyroid, adrenal, testicular, ovarian, and neuroendocrine cancers). These tools have placed several intriguing clues before the scientific community. Endocrine cancers pose a major challenge in health care and research despite considerable attempts by researchers to understand their etiology. Microarray analyses have provided gene signatures from many cells, tissues, and organs that can differentiate healthy states from diseased ones, and even show patterns that correlate with stages of a disease. Microarray data can also elucidate the responses of endocrine tumors to therapeutic treatments. The rapid progress in next-generation sequencing methods has overcome many of the initial challenges of these technologies, and their advantages over microarray techniques have enabled them to emerge as valuable aids for clinical research applications (prognosis, identification of drug targets, etc.). A comprehensive review describing the recent advances in next-generation sequencing methods and their application in the evaluation of endocrine and endocrine-related cancers is lacking. The main purpose of this review is to illustrate the concepts that collectively constitute our current view of the possibilities offered by next-generation sequencing technological platforms, challenges to relevant applications, and perspectives on the future of clinical genetic testing of patients with endocrine tumors. We focus on recent discoveries in the use of next-generation sequencing methods for clinical diagnosis of endocrine tumors in patients and conclude with a discussion on persisting challenges and future objectives.

The next generation CANDU 6

International Nuclear Information System (INIS)

Hopwood, J.M.

1999-01-01

AECL's product line of CANDU 6 and CANDU 9 nuclear power plants are adapted to respond to changing market conditions, experience feedback and technological development by a continuous improvement process of design evolution. The CANDU 6 Nuclear Power Plant design is a successful family of nuclear units, with the first four units entering service in 1983, and the most recent entering service this year. A further four CANDU 6 units are under construction. Starting in 1996, a focused forward-looking development program is under way at AECL to incorporate a series of individual improvements and integrate them into the CANDU 6, leading to the evolutionary development of the next-generation enhanced CANDU 6. The CANDU 6 improvements program includes all aspects of an NPP project, including engineering tools improvements, design for improved constructability, scheduling for faster, more streamlined commissioning, and improved operating performance. This enhanced CANDU 6 product will combine the benefits of design provenness (drawing on the more than 70 reactor-years experience of the seven operating CANDU 6 units), with the advantages of an evolutionary next-generation design. Features of the enhanced CANDU 6 design include: Advanced Human Machine Interface - built around the Advanced CANDU Control Centre; Advanced fuel design - using the newly demonstrated CANFLEX fuel bundle; Improved Efficiency based on improved utilization of waste heat; Streamlined System Design - including simplifications to improve performance and safety system reliability; Advanced Engineering Tools, -- featuring linked electronic databases from 3D CADDS, equipment specification and material management; Advanced Construction Techniques - based on open top equipment installation and the use of small skid mounted modules; Options defined for Passive Heat Sink capability and low-enrichment core optimization. (author)

Bioinformatics for Next Generation Sequencing Data

Directory of Open Access Journals (Sweden)

Alberto Magi

2010-09-01

Full Text Available The emergence of next-generation sequencing (NGS platforms imposes increasing demands on statistical methods and bioinformatic tools for the analysis and the management of the huge amounts of data generated by these technologies. Even at the early stages of their commercial availability, a large number of softwares already exist for analyzing NGS data. These tools can be fit into many general categories including alignment of sequence reads to a reference, base-calling and/or polymorphism detection, de novo assembly from paired or unpaired reads, structural variant detection and genome browsing. This manuscript aims to guide readers in the choice of the available computational tools that can be used to face the several steps of the data analysis workflow.

Next Generation HeliMag UXO Mapping Technology

Science.gov (United States)

2010-01-01

Ancillary instrumentation records aircraft height above ground and attitude. A fluxgate magnetometer is used to allow for aeromagnetic compensation of... Magnetometer System WWII World War II WAA wide area assessment ACKNOWLEDGEMENTS This Next Generation HeliMag Unexploded Ordnance (UXO) Mapping...for deployment of seven total-field magnetometers on a Kevlar reinforced boom mounted on a Bell 206L helicopter. The objectives of this

Application of Next Generation Sequencing on Genetic Testing

DEFF Research Database (Denmark)

Li, Jian

The discovery of genetic factors behind increasing number of human diseases and the growth of education of genetic knowledge to the public make demands for genetic testing increase rapidly. However, traditional genetic testing methods cannot meet all kinds of the requirements. Next generation seq...

HLA typing: Conventional techniques v. next-generation sequencing ...

African Journals Online (AJOL)

Background. The large number of population-specific polymorphisms present in the HLA complex in the South African (SA) population reduces the probability of finding an adequate HLA-matched donor for individuals in need of an unrelated haematopoietic stem cell transplantation (HSCT). Next-generation sequencing ...

NGSS and the Next Generation of Science Teachers

Science.gov (United States)

Bybee, Rodger W.

2014-01-01

This article centers on the "Next Generation Science Standards" (NGSS) and their implications for teacher development, particularly at the undergraduate level. After an introduction to NGSS and the influence of standards in the educational system, the article addresses specific educational shifts--interconnecting science and engineering…

Next-generation sequencing offers new insights into DNA degradation

DEFF Research Database (Denmark)

Overballe-Petersen, Søren; Orlando, Ludovic Antoine Alexandre; Willerslev, Eske

2012-01-01

The processes underlying DNA degradation are central to various disciplines, including cancer research, forensics and archaeology. The sequencing of ancient DNA molecules on next-generation sequencing platforms provides direct measurements of cytosine deamination, depurination and fragmentation...... rates that previously were obtained only from extrapolations of results from in vitro kinetic experiments performed over short timescales. For example, recent next-generation sequencing of ancient DNA reveals purine bases as one of the main targets of postmortem hydrolytic damage, through base...... elimination and strand breakage. It also shows substantially increased rates of DNA base-loss at guanosine. In this review, we argue that the latter results from an electron resonance structure unique to guanosine rather than adenosine having an extra resonance structure over guanosine as previously suggested....

Sistema de traducción de comandos de CISCO a AVAYA

OpenAIRE

Darwin Ramiro Mercado Polo

2010-01-01

Es especialmente relevante para la formación de los ingenieros de sistemas y profesionales de carreras afines, adquirir las competencias relacionadas con la configuración de dispositivos de comunicaciones presentes en redes informáticas, por tanto es muy importante que el estudiante aprenda a manejar una gran variedad de comandos aplicables en tales dispositivos. Los comandos varían de un dispositivo a otro, dependiendo de la empresa manufacturera, algunas de ellas son: CISCO System, AVAYA y ...

Buoyancy differences among two deepwater ciscoes from the Great Lakes and their putative ancestor

Science.gov (United States)

Krause, A.E.; Eshenroder, R.L.; Begnoche, L.J.

2002-01-01

We analyzed buoyancy in two deepwater ciscoes, Coregonus hoyi and C. kiyi, and in C. artedi, their putative ancestor, and also analyzed how variations in fish weight, water content, and lipid content affected buoyancy. Buoyancy was significantly different among the three species (p < 0.0001). Estimates of percent buoyancy (neutral buoyancy = 0.0%) were: kiyi, 3.8%; hoyi, 4.7%; and artedi, 5.7%. Buoyancy did not change with fish weight alone (p = 0.38). Fish weight was negatively related to water content for all three species (p = 0.037). Lipid content was not significantly different between hoyi and kiyi, but artedi had significantly fewer lipids than hoyi and kiyi (p < 0.10). When artedi was removed from the analysis, fish weight and lipids accounted for 48% of the variation in buoyancy (p = 0.003), fatter hoyi were less dense than leaner hoyi, but fatter and leaner kiyi were no different in density. Our findings provide additional evidence that buoyancy regulation was a speciating mechanism in deepwater ciscoes and that kiyi is more specialized than hoyi for diel-vertical migration in deep water.

NOAA Next Generation Radar (NEXRAD) Level 2 Base Data

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This dataset consists of Level II weather radar data collected from Next-Generation Radar (NEXRAD) stations located in the contiguous United States, Alaska, Hawaii,...

Event generators

International Nuclear Information System (INIS)

Durand, D.; Gulminelli, F.; Lopez, O.; Vient, E.

1998-01-01

The results concerning the heavy ion collision simulations at Fermi energies by means of phenomenological models obtained in the last two years ar presented. The event generators are essentially following the phase of elaboration of analysis methods of data obtained by INDRA or NAUTILUS 4 π multidetectors. To identify and correctly quantify a phenomenon or a physical quantity it is necessary to verify by simulation the feasibility and validity of the analysis and also to estimate the bias introduced by the experimental filter. Many studies have shown this, for instance: the determination of the collision reaction plan for flow studies, determination of kinematical characteristics of the quasi-projectiles, and the excitation energy measurement stored in the hot nuclei. To Eugene, the currently utilised generator, several improvements were added: introduction of space-time correlations between the different products emitted in the decay of excited nuclei by calculating the trajectories of the particles in the final phase of the reaction; taking into account in the decay cascade of the discrete levels of the lighter fragments; the possibility of the schematically description of the explosion of the nucleus by simultaneous emission of multi-fragments. Thus, by comparing the calculations with the data relative to heavy systems studied with the NAUTILUS assembly it was possible to extract the time scales in the nuclear fragmentation. The utilisation of these event generators was extended to the analysis of INDRA data concerning the determination of the vaporization threshold in the collisions Ar + Ni and also the research of the expansion effects in the collisions Xe + Sn at 50 MeV/u

76 FR 77939 - Proposed Provision of Navigation Services for the Next Generation Air Transportation System...

Science.gov (United States)

2011-12-15

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Parts 91, 121, 125, 129, and 135 Proposed Provision of Navigation Services for the Next Generation Air Transportation System (Next...) navigation infrastructure to enable performance-based navigation (PBN) as part of the Next Generation Air...

Cloud Sourcing – Next Generation Outsourcing?

OpenAIRE

Muhic, Mirella; Johansson, Björn

2014-01-01

Although Cloud Sourcing has been around for some time it could be questioned what actually is known about it. This paper presents a literature review on the specific question if Cloud Sourcing could be seen as the next generation of outsourcing. The reason for doing this is that from an initial sourcing study we found that the sourcing decisions seems to go in the direction of outsourcing as a service which could be described as Cloud Sourcing. Whereas some are convinced that Cloud Sourcing r...

Securing Networks from Modern Threats using Next Generation Firewalls

OpenAIRE

Delgiusto, Valter

2016-01-01

Classic firewalls have long been unable to cope with modern threats that ordinary Internet users are exposed to. This thesis discusses their successors - the next-generation firewalls. The first part of the thesis describes modern threats and attacks. We described in detail the DoS and APT attacks, which are among the most frequent and which may cause most damage to the system under attack. Then we explained the theoretical basics of firewalls and described the functionalities of next gen...

Next generation of energy production systems

International Nuclear Information System (INIS)

Rouault, J.; Garnier, J.C.; Carre, F.

2003-01-01

This document gathers the slides that have been presented at the Gedepeon conference. Gedepeon is a research group involving scientists from Cea (French atomic energy commission), CNRS (national center of scientific research), EDF (electricity of France) and Framatome that is devoted to the study of new energy sources and particularly to the study of the future generations of nuclear systems. The contributions have been classed into 9 topics: 1) gas cooled reactors, 2) molten salt reactors (MSBR), 3) the recycling of plutonium and americium, 4) reprocessing of molten salt reactor fuels, 5) behavior of graphite under radiation, 6) metallic materials for molten salt reactors, 7) refractory fuels of gas cooled reactors, 8) the nuclear cycle for the next generations of nuclear systems, and 9) organization of research programs on the new energy sources

The Use of Next Generation Sequencing and Junction Sequence Analysis Bioinformatics to Achieve Molecular Characterization of Crops Improved Through Modern Biotechnology

Directory of Open Access Journals (Sweden)

David Kovalic

2012-11-01

Full Text Available The assessment of genetically modified (GM crops for regulatory approval currently requires a detailed molecular characterization of the DNA sequence and integrity of the transgene locus. In addition, molecular characterization is a critical component of event selection and advancement during product development. Typically, molecular characterization has relied on Southern blot analysis to establish locus and copy number along with targeted sequencing of polymerase chain reaction products spanning any inserted DNA to complete the characterization process. Here we describe the use of next generation (NexGen sequencing and junction sequence analysis bioinformatics in a new method for achieving full molecular characterization of a GM event without the need for Southern blot analysis. In this study, we examine a typical GM soybean [ (L. Merr.] line and demonstrate that this new method provides molecular characterization equivalent to the current Southern blot-based method. We also examine an event containing in vivo DNA rearrangement of multiple transfer DNA inserts to demonstrate that the new method is effective at identifying complex cases. Next generation sequencing and bioinformatics offers certain advantages over current approaches, most notably the simplicity, efficiency, and consistency of the method, and provides a viable alternative for efficiently and robustly achieving molecular characterization of GM crops.

Novel nanostructures for next generation dye-sensitized solar cells

KAUST Repository

Té treault, Nicolas; Grä tzel, Michael

2012-01-01

Herein, we review our latest advancements in nanostructured photoanodes for next generation photovoltaics in general and dye-sensitized solar cells in particular. Bottom-up self-assembly techniques are developed to fabricate large-area 3D

Next generation HOM-damping

Science.gov (United States)

Marhauser, Frank

2017-06-01

Research and development for superconducting radio-frequency cavities has made enormous progress over the last decades from the understanding of theoretical limitations to the industrial mass fabrication of cavities for large-scale particle accelerators. Key technologies remain hot topics due to continuously growing demands on cavity performance, particularly when in pursuit of high quality beams at higher beam currents or higher luminosities than currently achievable. This relates to higher order mode (HOM) damping requirements. Meeting the desired beam properties implies avoiding coupled multi-bunch or beam break-up instabilities depending on the machine and beam parameters that will set the acceptable cavity impedance thresholds. The use of cavity HOM-dampers is crucial to absorb the wakefields, comprised by all beam-induced cavity Eigenmodes, to beam-dynamically safe levels and to reduce the heat load at cryogenic temperature. Cavity damping concepts may vary, but are principally based on coaxial and waveguide couplers as well as beam line absorbers or any combination. Next generation energy recovery linacs and circular colliders call for cavities with strong HOM-damping that can exceed the state-of-the-art, while the operating mode efficiency shall not be significantly compromised concurrently. This imposes major challenges given the rather limited damping concepts. A detailed survey of established cavities is provided scrutinizing the achieved damping performance, shortcomings, and potential improvements. The scaling of the highest passband mode impedances is numerically evaluated in dependence on the number of cells for a single-cell up to a nine-cell cavity, which reveals the increased probability of trapped modes. This is followed by simulations for single-cell and five-cell cavities, which incorporate multiple damping schemes to assess the most efficient concepts. The usage and viability of on-cell dampers is elucidated for the single-cell cavity since it

The Caballero Revisited: Postmodernity in "The Cisco Kid", "The Mask of Zorro", and "Shrek II"

Science.gov (United States)

Leen, Catherine

2007-01-01

This article discusses the achievement of the postmodern caballero films and the relevance of the social bandit myth for Chicano resistance. The continued relevance of the social bandit myth is clearly demonstrated by "The Cisco Kid" and "The Mask of Zorro." Both films show how initially flawed or directionless characters can…

Next Generation Science Standards: All Standards, All Students

Science.gov (United States)

Lee, Okhee; Miller, Emily C.; Januszyk, Rita

2014-01-01

The Next Generation Science Standards (NGSS) offer a vision of science teaching and learning that presents both learning opportunities and demands for all students, particularly student groups that have traditionally been underserved in science classrooms. The NGSS have addressed issues of diversity and equity from their inception, and the NGSS…

Next-Generation Intensity-Duration-Frequency Curves for Hydrologic Design in Snow-Dominated Environments

Science.gov (United States)

Yan, Hongxiang; Sun, Ning; Wigmosta, Mark; Skaggs, Richard; Hou, Zhangshuan; Leung, Ruby

2018-02-01

There is a renewed focus on the design of infrastructure resilient to extreme hydrometeorological events. While precipitation-based intensity-duration-frequency (IDF) curves are commonly used as part of infrastructure design, a large percentage of peak runoff events in snow-dominated regions are caused by snowmelt, particularly during rain-on-snow (ROS) events. In these regions, precipitation-based IDF curves may lead to substantial overestimation/underestimation of design basis events and subsequent overdesign/underdesign of infrastructure. To overcome this deficiency, we proposed next-generation IDF (NG-IDF) curves, which characterize the actual water reaching the land surface. We compared NG-IDF curves to standard precipitation-based IDF curves for estimates of extreme events at 376 Snowpack Telemetry (SNOTEL) stations across the western United States that each had at least 30 years of high-quality records. We found standard precipitation-based IDF curves at 45% of the stations were subject to underdesign, many with significant underestimation of 100 year extreme events, for which the precipitation-based IDF curves can underestimate water potentially available for runoff by as much as 125% due to snowmelt and ROS events. The regions with the greatest potential for underdesign were in the Pacific Northwest, the Sierra Nevada Mountains, and the Middle and Southern Rockies. We also found the potential for overdesign at 20% of the stations, primarily in the Middle Rockies and Arizona mountains. These results demonstrate the need to consider snow processes in the development of IDF curves, and they suggest use of the more robust NG-IDF curves for hydrologic design in snow-dominated environments.

Next generation advanced nuclear reactor designs

International Nuclear Information System (INIS)

Turgut, M. H.

2009-01-01

Growing energy demand by technological developments and the increase of the world population and gradually diminishing energy resources made nuclear power an indispensable option. The renewable energy sources like solar, wind and geothermal may be suited to meet some local needs. Environment friendly nuclear energy which is a suitable solution to large scale demands tends to develop highly economical, advanced next generation reactors by incorporating technological developments and years of operating experience. The enhancement of safety and reliability, facilitation of maintainability, impeccable compatibility with the environment are the goals of the new generation reactors. The protection of the investment and property is considered as well as the protection of the environment and mankind. They became economically attractive compared to fossil-fired units by the use of standard designs, replacing some active systems by passive, reducing construction time and increasing the operation lifetime. The evolutionary designs were introduced at first by ameliorating the conventional plants, than revolutionary systems which are denoted as generation IV were verged to meet future needs. The investigations on the advanced, proliferation resistant fuel cycle technologies were initiated to minimize the radioactive waste burden by using new generation fast reactors and ADS transmuters.

Next-Generation Sequencing in the Mycology Lab.

Science.gov (United States)

Zoll, Jan; Snelders, Eveline; Verweij, Paul E; Melchers, Willem J G

New state-of-the-art techniques in sequencing offer valuable tools in both detection of mycobiota and in understanding of the molecular mechanisms of resistance against antifungal compounds and virulence. Introduction of new sequencing platform with enhanced capacity and a reduction in costs for sequence analysis provides a potential powerful tool in mycological diagnosis and research. In this review, we summarize the applications of next-generation sequencing techniques in mycology.

Fiber to the home: next generation network

Science.gov (United States)

Yang, Chengxin; Guo, Baoping

2006-07-01

Next generation networks capable of carrying converged telephone, television (TV), very high-speed internet, and very high-speed bi-directional data services (like video-on-demand (VOD), Game etc.) strategy for Fiber To The Home (FTTH) is presented. The potential market is analyzed. The barriers and some proper strategy are also discussed. Several technical problems like various powering methods, optical fiber cables, and different network architecture are discussed too.

Next-Generation Thermal Infrared Multi-Body Radiometer Experiment (TIMBRE)

Science.gov (United States)

Kenyon, M.; Mariani, G.; Johnson, B.; Brageot, E.; Hayne, P.

2016-10-01

We have developed an instrument concept called TIMBRE which belongs to the important class of instruments called thermal imaging radiometers (TIRs). TIMBRE is the next-generation TIR with unparalleled performance compared to the state-of-the-art.

Next generation ATCA control infrastructure for the CMS Phase-2 upgrades

CERN Document Server

Smith, Wesley; Svetek, Aleš; Tikalsky, Jes; Fobes, Robert; Dasu, Sridhara; Smith, Wesley; Vicente, Marcelo

2017-01-01

A next generation control infrastructure to be used in Advanced TCA (ATCA) blades at CMS experiment is being designed and tested. Several ATCA systems are being prepared for the High-Luminosity LHC (HL-LHC) and will be installed at CMS during technical stops. The next generation control infrastructure will provide all the necessary hardware, firmware and software required in these systems, decreasing development time and increasing flexibility. The complete infrastructure includes an Intelligent Platform Management Controller (IPMC), a Module Management Controller (MMC) and an Embedded Linux Mezzanine (ELM) processing card.

What can next generation sequencing do for you? Next generation sequencing as a valuable tool in plant research

OpenAIRE

Bräutigam, Andrea; Gowik, Udo

2010-01-01

Next generation sequencing (NGS) technologies have opened fascinating opportunities for the analysis of plants with and without a sequenced genome on a genomic scale. During the last few years, NGS methods have become widely available and cost effective. They can be applied to a wide variety of biological questions, from the sequencing of complete eukaryotic genomes and transcriptomes, to the genome-scale analysis of DNA-protein interactions. In this review, we focus on the use of NGS for pla...

Targeted enrichment strategies for next-generation plant biology

Science.gov (United States)

Richard Cronn; Brian J. Knaus; Aaron Liston; Peter J. Maughan; Matthew Parks; John V. Syring; Joshua. Udall

2012-01-01

The dramatic advances offered by modem DNA sequencers continue to redefine the limits of what can be accomplished in comparative plant biology. Even with recent achievements, however, plant genomes present obstacles that can make it difficult to execute large-scale population and phylogenetic studies on next-generation sequencing platforms. Factors like large genome...

Next Generation Science Standards: Adoption and Implementation Workbook

Science.gov (United States)

Peltzman, Alissa; Rodriguez, Nick

2013-01-01

The Next Generation Science Standards (NGSS) represent the culmination of years of collaboration and effort by states, science educators and experts from across the United States. Based on the National Research Council's "A Framework for K-12 Science Education" and developed in partnership with 26 lead states, the NGSS, when…

Framework for Leading Next Generation Science Standards Implementation

Science.gov (United States)

Stiles, Katherine; Mundry, Susan; DiRanna, Kathy

2017-01-01

In response to the need to develop leaders to guide the implementation of the Next Generation Science Standards (NGSS), the Carnegie Corporation of New York provided funding to WestEd to develop a framework that defines the leadership knowledge and actions needed to effectively implement the NGSS. The development of the framework entailed…

Mobility management techniques for the next-generation wireless networks

Science.gov (United States)

Sun, Junzhao; Howie, Douglas P.; Sauvola, Jaakko J.

2001-10-01

The tremendous demands from social market are pushing the booming development of mobile communications faster than ever before, leading to plenty of new advanced techniques emerging. With the converging of mobile and wireless communications with Internet services, the boundary between mobile personal telecommunications and wireless computer networks is disappearing. Wireless networks of the next generation need the support of all the advances on new architectures, standards, and protocols. Mobility management is an important issue in the area of mobile communications, which can be best solved at the network layer. One of the key features of the next generation wireless networks is all-IP infrastructure. This paper discusses the mobility management schemes for the next generation mobile networks through extending IP's functions with mobility support. A global hierarchical framework model for the mobility management of wireless networks is presented, in which the mobility management is divided into two complementary tasks: macro mobility and micro mobility. As the macro mobility solution, a basic principle of Mobile IP is introduced, together with the optimal schemes and the advances in IPv6. The disadvantages of the Mobile IP on solving the micro mobility problem are analyzed, on the basis of which three main proposals are discussed as the micro mobility solutions for mobile communications, including Hierarchical Mobile IP (HMIP), Cellular IP, and Handoff-Aware Wireless Access Internet Infrastructure (HAWAII). A unified model is also described in which the different micro mobility solutions can coexist simultaneously in mobile networks.

Designing Next Generation Massively Multithreaded Architectures for Irregular Applications

Energy Technology Data Exchange (ETDEWEB)

Tumeo, Antonino; Secchi, Simone; Villa, Oreste

2012-08-31

Irregular applications, such as data mining or graph-based computations, show unpredictable memory/network access patterns and control structures. Massively multi-threaded architectures with large node count, like the Cray XMT, have been shown to address their requirements better than commodity clusters. In this paper we present the approaches that we are currently pursuing to design future generations of these architectures. First, we introduce the Cray XMT and compare it to other multithreaded architectures. We then propose an evolution of the architecture, integrating multiple cores per node and next generation network interconnect. We advocate the use of hardware support for remote memory reference aggregation to optimize network utilization. For this evaluation we developed a highly parallel, custom simulation infrastructure for multi-threaded systems. Our simulator executes unmodified XMT binaries with very large datasets, capturing effects due to contention and hot-spotting, while predicting execution times with greater than 90% accuracy. We also discuss the FPGA prototyping approach that we are employing to study efficient support for irregular applications in next generation manycore processors.

Next Generation Summer School

Science.gov (United States)

Eugenia, Marcu

2013-04-01

On 21.06.2010 the "Next Generation" Summer School has opened the doors for its first students. They were introduced in the astronomy world by astronomical observations, astronomy and radio-astronomy lectures, laboratory projects meant to initiate them into modern radio astronomy and radio communications. The didactic programme was structure as fallowing: 1) Astronomical elements from the visible spectrum (lectures + practical projects) 2) Radio astronomy elements (lectures + practical projects) 3) Radio communication base (didactic- recreative games) The students and professors accommodation was at the Agroturistic Pension "Popasul Iancului" situated at 800m from the Marisel Observatory. First day (summer solstice day) began with a practical activity: determination of the meridian by measurements of the shadow (the direction of one vertical alignment, when it has the smallest length). The experiment is very instructive and interesting because combines notions of physics, spatial geometry and basic astronomy elements. Next day the activities took place in four stages: the students processed the experimental data obtained on first day (on sheets of millimetre paper they represented the length of the shadow alignments according the time), each team realised its own sun quadrant, point were given considering the design and functionality of these quadrant, the four teams had to mimic important constellations on carton boards with phosphorescent sticky stars and the students, accompanied by the professors took a hiking trip to the surroundings, marking the interest point coordinates, using a GPS to establish the geographical coronations and at the end of the day the students realised a small map of central Marisel area based on the GPS data. On the third day, the students were introduced to basic notions of radio astronomy, the principal categories of artificial Earth satellites: low orbit satellites (LEO), Medium orbit satellites (MEO) and geostationary satellites (GEO

Ontogenetic shifts in morphology and resource use of cisco Coregonus artedi.

Science.gov (United States)

Muir, A M; Vecsei, P; Pratt, T C; Krueger, C C; Power, M; Reist, J D

2013-02-01

Two previously described lacustrine cisco Coregonus spp. morphs [i.e. a small (cisco Coregonus artedi. Geometric body shape did not differ between the two size classes nor could they be differentiated by 24 size-corrected linear measurements, indicating that the two groups had similar phenotypes. Strong, positive correlations between all linear characters and geometric centroid size (a composite variable of fish body length, mass and age) suggested that body morphology changed with age as fish grew. Total gillraker number (N(GR)) increased with L(F) according to: N(GR) = 36.3 + 0.034L(F). Differences in gillraker number and phenotype with age and size were explained by shifts in habitat and trophic resource use. Relative abundance within 0-30, 30-60, 60-90 and >90 m depth strata differed between size classes suggesting that morphology changed when fish shifted their habitat as they grew older. Large C. artedi had lower δ(13)C and slightly higher δ(15)N, indicating greater reliance on pelagic prey resources (i.e. more or larger zooplankton, such as Mysis spp.), compared to small C. artedi, which relied slightly more on benthic prey. Gillraker shape and number have always been used as key diagnostic characters in coregonine taxonomy; based on the findings presented here, ontogenetic shifts should be accounted for in resulting classifications. © 2013 The Authors. Journal of Fish Biology © 2013 The Fisheries Society of the British Isles.

Next-generation batteries and fuel cells for commercial, military, and space applications

CERN Document Server

Jha, A R

2012-01-01

Distilling complex theoretical physical concepts into an understandable technical framework, Next-Generation Batteries and Fuel Cells for Commercial, Military, and Space Applications describes primary and secondary (rechargeable) batteries for various commercial, military, spacecraft, and satellite applications for covert communications, surveillance, and reconnaissance missions. It emphasizes the cost, reliability, longevity, and safety of the next generation of high-capacity batteries for applications where high energy density, minimum weight and size, and reliability in harsh conditions are

Foam A General Purpose Cellular Monte Carlo Event Generator

CERN Document Server

Jadach, Stanislaw

2003-01-01

A general purpose, self-adapting, Monte Carlo (MC) event generator (simulator) is described. The high efficiency of the MC, that is small maximum weight or variance of the MC weight is achieved by means of dividing the integration domain into small cells. The cells can be $n$-dimensional simplices, hyperrectangles or Cartesian product of them. The grid of cells, called ``foam'', is produced in the process of the binary split of the cells. The choice of the next cell to be divided and the position/direction of the division hyper-plane is driven by the algorithm which optimizes the ratio of the maximum weight to the average weight or (optionally) the total variance. The algorithm is able to deal, in principle, with an arbitrary pattern of the singularities in the distribution. As any MC generator, it can also be used for the MC integration. With the typical personal computer CPU, the program is able to perform adaptive integration/simulation at relatively small number of dimensions ($\\leq 16$). With the continu...

Next generation data harmonization

Science.gov (United States)

Armstrong, Chandler; Brown, Ryan M.; Chaves, Jillian; Czerniejewski, Adam; Del Vecchio, Justin; Perkins, Timothy K.; Rudnicki, Ron; Tauer, Greg

2015-05-01

Analysts are presented with a never ending stream of data sources. Often, subsets of data sources to solve problems are easily identified but the process to align data sets is time consuming. However, many semantic technologies do allow for fast harmonization of data to overcome these problems. These include ontologies that serve as alignment targets, visual tools and natural language processing that generate semantic graphs in terms of the ontologies, and analytics that leverage these graphs. This research reviews a developed prototype that employs all these approaches to perform analysis across disparate data sources documenting violent, extremist events.

Convergence of wireless, wireline, and photonics next generation networks

CERN Document Server

Iniewski, Krzysztof

2010-01-01

Filled with illustrations and practical examples from industry, this book provides a brief but comprehensive introduction to the next-generation wireless networks that will soon replace more traditional wired technologies. Written by a mixture of top industrial experts and key academic professors, it is the only book available that covers both wireless networks (such as wireless local area and personal area networks) and optical networks (such as long-haul and metropolitan networks) in one volume. It gives engineers and engineering students the necessary knowledge to meet challenges of next-ge

MadGraph/MadEvent. The new web generation

International Nuclear Information System (INIS)

Alwall, J.

2007-01-01

The new web-based version of the automatized process and event generator MadGraph/MadEvent is now available. Recent developments are: New models, notably MSSM, 2HDM and a framework for addition of user-defined models, inclusive sample generation and on-line hadronization and detector simulation. Event generation can be done on-line on any of our clusters. (author)

Efficient Cryptography for the Next Generation Secure Cloud

Science.gov (United States)

Kupcu, Alptekin

2010-01-01

Peer-to-peer (P2P) systems, and client-server type storage and computation outsourcing constitute some of the major applications that the next generation cloud schemes will address. Since these applications are just emerging, it is the perfect time to design them with security and privacy in mind. Furthermore, considering the high-churn…

Developing next-generation telehealth tools and technologies: patients, systems, and data perspectives.

Science.gov (United States)

Ackerman, Michael J; Filart, Rosemarie; Burgess, Lawrence P; Lee, Insup; Poropatich, Ronald K

2010-01-01

The major goals of telemedicine today are to develop next-generation telehealth tools and technologies to enhance healthcare delivery to medically underserved populations using telecommunication technology, to increase access to medical specialty services while decreasing healthcare costs, and to provide training of healthcare providers, clinical trainees, and students in health-related fields. Key drivers for these tools and technologies are the need and interest to collaborate among telehealth stakeholders, including patients, patient communities, research funders, researchers, healthcare services providers, professional societies, industry, healthcare management/economists, and healthcare policy makers. In the development, marketing, adoption, and implementation of these tools and technologies, communication, training, cultural sensitivity, and end-user customization are critical pieces to the process. Next-generation tools and technologies are vehicles toward personalized medicine, extending the telemedicine model to include cell phones and Internet-based telecommunications tools for remote and home health management with video assessment, remote bedside monitoring, and patient-specific care tools with event logs, patient electronic profile, and physician note-writing capability. Telehealth is ultimately a system of systems in scale and complexity. To cover the full spectrum of dynamic and evolving needs of end-users, we must appreciate system complexity as telehealth moves toward increasing functionality, integration, interoperability, outreach, and quality of service. Toward that end, our group addressed three overarching questions: (1) What are the high-impact topics? (2) What are the barriers to progress? and (3) What roles can the National Institutes of Health and its various institutes and centers play in fostering the future development of telehealth?

Statistical Approaches for Next-Generation Sequencing Data

OpenAIRE

Qiao, Dandi

2012-01-01

During the last two decades, genotyping technology has advanced rapidly, which enabled the tremendous success of genome-wide association studies (GWAS) in the search of disease susceptibility loci (DSLs). However, only a small fraction of the overall predicted heritability can be explained by the DSLs discovered. One possible explanation for this ”missing heritability” phenomenon is that many causal variants are rare. The recent development of high-throughput next-generation sequencing (NGS) ...

Architectural and Algorithmic Requirements for a Next-Generation System Analysis Code

Energy Technology Data Exchange (ETDEWEB)

V.A. Mousseau

2010-05-01

This document presents high-level architectural and system requirements for a next-generation system analysis code (NGSAC) to support reactor safety decision-making by plant operators and others, especially in the context of light water reactor plant life extension. The capabilities of NGSAC will be different from those of current-generation codes, not only because computers have evolved significantly in the generations since the current paradigm was first implemented, but because the decision-making processes that need the support of next-generation codes are very different from the decision-making processes that drove the licensing and design of the current fleet of commercial nuclear power reactors. The implications of these newer decision-making processes for NGSAC requirements are discussed, and resulting top-level goals for the NGSAC are formulated. From these goals, the general architectural and system requirements for the NGSAC are derived.

Designing Next Generation Telecom Regulation

DEFF Research Database (Denmark)

Henten, Anders; Samarajiva, Rohan

– ICT convergence regulation and multisector utility regulation. Whatever structure of next generation telecom regulation is adopted, all countries will need to pay much greater attention to the need for increased coordination of policy directions and regulatory activities both across the industries......Continuously expanding applications of information and communication technologies (ICT) are transforming local, national, regional and international economies into network economies, the foundation for information societies. They are being built upon expanded and upgraded national telecom networks...... to creating an environment to foster a massive expansion in the coverage and capabilities of the information infrastructure networks, with national telecom regulators as the key implementers of the policies of reform. The first phase of reform has focused on industry specific telecom policy and regulation...

ERP II: Next-generation Extended Enterprise Resource Planning

DEFF Research Database (Denmark)

Møller, Charles

2004-01-01

ERP II (ERP/2) systems is a new concept introduced by Gartner Group in 2000 in order to label the latest extensions of the ERP-systems. The purpose of this paper is to explore the next-generation of ERP systems, the Extended Enterprise Resource Planning (EERP or as we prefer to use: e...... impact on extended enterprise architecture.....

ERP II - Next-generation Extended Enterprise Resource Planning

DEFF Research Database (Denmark)

Møller, Charles

2003-01-01

ERP II (ERP/2) systems is a new concept introduced by Gartner Group in 2000 in order to label the latest extensions of the ERP-systems. The purpose of this paper is to explore the next-generation of ERP systems, the Extended Enterprise Resource Planning (EERP or as we prefer to use: e...... impact on extended enterprise architecture....

Next Generation Geothermal Power Plants

Energy Technology Data Exchange (ETDEWEB)

Brugman, John; Hattar, Mai; Nichols, Kenneth; Esaki, Yuri

1995-09-01

A number of current and prospective power plant concepts were investigated to evaluate their potential to serve as the basis of the next generation geothermal power plant (NGGPP). The NGGPP has been envisaged as a power plant that would be more cost competitive (than current geothermal power plants) with fossil fuel power plants, would efficiently use resources and mitigate the risk of reservoir under-performance, and minimize or eliminate emission of pollutants and consumption of surface and ground water. Power plant concepts were analyzed using resource characteristics at ten different geothermal sites located in the western United States. Concepts were developed into viable power plant processes, capital costs were estimated and levelized busbar costs determined. Thus, the study results should be considered as useful indicators of the commercial viability of the various power plants concepts that were investigated. Broadly, the different power plant concepts that were analyzed in this study fall into the following categories: commercial binary and flash plants, advanced binary plants, advanced flash plants, flash/binary hybrid plants, and fossil/geothed hybrid plants. Commercial binary plants were evaluated using commercial isobutane as a working fluid; both air-cooling and water-cooling were considered. Advanced binary concepts included cycles using synchronous turbine-generators, cycles with metastable expansion, and cycles utilizing mixtures as working fluids. Dual flash steam plants were used as the model for the commercial flash cycle. The following advanced flash concepts were examined: dual flash with rotary separator turbine, dual flash with steam reheater, dual flash with hot water turbine, and subatmospheric flash. Both dual flash and binary cycles were combined with other cycles to develop a number of hybrid cycles: dual flash binary bottoming cycle, dual flash backpressure turbine binary cycle, dual flash gas turbine cycle, and binary gas turbine

Environmental Information for the U.S. Next Generation Air Transportation System (NextGen)

Science.gov (United States)

Murray, J.; Miner, C.; Pace, D.; Minnis, P.; Mecikalski, J.; Feltz, W.; Johnson, D.; Iskendarian, H.; Haynes, J.

2009-09-01

It is estimated that weather is responsible for approximately 70% of all air traffic delays and cancellations in the United States. Annually, this produces an overall economic loss of nearly 40B. The FAA and NASA have determined that weather impacts and other environmental constraints on the U.S. National Airspace System (NAS) will increase to the point of system unsustainability unless the NAS is radically transformed. A Next Generation Air Transportation System (NextGen) is planned to accommodate the anticipated demand for increased system capacity and the super-density operations that this transformation will entail. The heart of the environmental information component that is being developed for NextGen will be a 4-dimensional data cube which will include a single authoritative source comprising probabilistic weather information for NextGen Air Traffic Management (ATM) systems. Aviation weather constraints and safety hazards typically comprise meso-scale, storm-scale and microscale observables that can significantly impact both terminal and enroute aviation operations. With these operational impacts in mind, functional and performance requirements for the NextGen weather system were established which require significant improvements in observation and forecasting capabilities. This will include satellite observations from geostationary and/or polar-orbiting hyperspectral sounders, multi-spectral imagers, lightning mappers, space weather monitors and other environmental observing systems. It will also require improved in situ and remotely sensed observations from ground-based and airborne systems. These observations will be used to better understand and to develop forecasting applications for convective weather, in-flight icing, turbulence, ceilings and visibility, volcanic ash, space weather and the environmental impacts of aviation. Cutting-edge collaborative research efforts and results from NASA, NOAA and the FAA which address these phenomena are summarized

The contribution of next generation sequencing to epilepsy genetics

DEFF Research Database (Denmark)

Møller, Rikke S.; Dahl, Hans A.; Helbig, Ingo

2015-01-01

During the last decade, next generation sequencing technologies such as targeted gene panels, whole exome sequencing and whole genome sequencing have led to an explosion of gene identifications in monogenic epilepsies including both familial epilepsies and severe epilepsies, often referred to as ...

Converged Wireless Networking and Optimization for Next Generation Services

Directory of Open Access Journals (Sweden)

J. Rodriguez

2010-01-01

Full Text Available The Next Generation Network (NGN vision is tending towards the convergence of internet and mobile services providing the impetus for new market opportunities in combining the appealing services of internet with the roaming capability of mobile networks. However, this convergence does not go far enough, and with the emergence of new coexistence scenarios, there is a clear need to evolve the current architecture to provide cost-effective end-to-end communication. The LOOP project, a EUREKA-CELTIC driven initiative, is one piece in the jigsaw by helping European industry to sustain a leading role in telecommunications and manufacturing of high-value products and machinery by delivering pioneering converged wireless networking solutions that can be successfully demonstrated. This paper provides an overview of the LOOP project and the key achievements that have been tunneled into first prototypes for showcasing next generation services for operators and process manufacturers.

Cost and schedule reduction for next-generation Candu

International Nuclear Information System (INIS)

Hopwood, J.M.; Yu, S.; Pakan, M.; Soulard, M.

2002-01-01

AECL has developed a suite of technologies for Candu R reactors that enable the next step in the evolution of the Candu family of heavy-water-moderated fuel-channel reactors. These technologies have been combined in the design for the Advanced Candu Reactor TM1 (ACRTM), AECL's next generation Candu power plant. The ACR design builds extensively on the existing Candu experience base, but includes innovations, in design and in delivery technology, that provide very substantial reductions in capital cost and in project schedules. In this paper, main features of next generation design and delivery are summarized, to provide the background basis for the cost and schedule reductions that have been achieved. In particular the paper outlines the impact of the innovative design steps for ACR: - Selection of slightly enriched fuel bundle design; - Use of light water coolant in place of traditional Candu heavy water coolant; - Compact core design with unique reactor physics benefits; - Optimized coolant and turbine system conditions. In addition to the direct cost benefits arising from efficiency improvement, and from the reduction in heavy water, the next generation Candu configuration results in numerous additional indirect cost benefits, including: - Reduction in number and complexity of reactivity mechanisms; - Reduction in number of heavy water auxiliary systems; - Simplification in heat transport and its support systems; - Simplified human-machine interface. The paper also describes the ACR approach to design for constructability. The application of module assembly and open-top construction techniques, based on Candu and other worldwide experience, has been proven to generate savings in both schedule durations and overall project cost, by reducing premium on-site activities, and by improving efficiency of system and subsystem assembly. AECL's up-to-date experience in the use of 3-D CADDS and related engineering tools has also been proven to reduce both engineering and

Next-Generation Intensity-Duration-Frequency Curves for Hydrologic Design in Snow-Dominated Environments

Energy Technology Data Exchange (ETDEWEB)

Yan, Hongxiang [Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland Washington United States; Sun, Ning [Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland Washington United States; Wigmosta, Mark [Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland Washington United States; Distinguished Faculty Fellow, Department of Civil and Environmental Engineering, University of Washington, Seattle Washington United States; Skaggs, Richard [Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland Washington United States; Hou, Zhangshuan [Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland Washington United States; Leung, Ruby [Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland Washington United States

2018-02-01

There is a renewed focus on the design of infrastructure resilient to extreme hydrometeorological events. While precipitation-based intensity-duration-frequency (IDF) curves are commonly used as part of infrastructure design, a large percentage of peak runoff events in snow-dominated regions are caused by snowmelt, particularly during rain-on-snow (ROS) events. In these regions, precipitation-based IDF curves may lead to substantial over-/under-estimation of design basis events and subsequent over-/under-design of infrastructure. To overcome this deficiency, we proposed next-generation IDF (NG-IDF) curves, which characterize the actual water reaching the land surface. We compared NG-IDF curves to standard precipitation-based IDF curves for estimates of extreme events at 376 Snowpack Telemetry (SNOTEL) stations across the western United States that each had at least 30 years of high-quality records. We found standard precipitation-based IDF curves at 45% of the stations were subject to under-design, many with significant under-estimation of 100-year extreme events, for which the precipitation-based IDF curves can underestimate water potentially available for runoff by as much as 125% due to snowmelt and ROS events. The regions with the greatest potential for under-design were in the Pacific Northwest, the Sierra Nevada Mountains, and the Middle and Southern Rockies. We also found the potential for over-design at 20% of the stations, primarily in the Middle Rockies and Arizona mountains. These results demonstrate the need to consider snow processes in the development of IDF curves, and they suggest use of the more robust NG-IDF curves for hydrologic design in snow-dominated environments.

The DOE Next-Generation Drivetrain for Wind Turbine Applications: Gearbox, Generator, and Advanced Si/SiC Hybrid Inverter System: Preprint

Energy Technology Data Exchange (ETDEWEB)

Erdman, William; Keller, Jonathan

2016-08-01

This paper reports on the design and testing results from the U.S. Department of Energy Next-Generation Wind Turbine Drivetrain Project. The drivetrain design reduces the cost of energy by increasing energy capture through drivetrain efficiency improvements; by reducing operation and maintenance costs through reducing gearbox failures; and by lowering capital costs through weight reduction and a series of mechanical and electronic innovations. The paper provides an overview of the drivetrain gearbox and generator and provides a deeper look into the power converter system. The power converter has a number of innovations including the use of hybrid silicon (Si)/silicon carbide (SiC) isolated baseplate switching modules. Switching energies are compared between SiC and Si PIN diodes. The efficiency improvement by use of the SiC diode in a three-level converter is also described. Finally, a brief discussion covering utility interconnect requirements for turbines is provided with a particular focus on utility events that lead to high transient torque loads on drivetrain mechanical elements.

Next-Generation Sequencing of Antibody Display Repertoires

Directory of Open Access Journals (Sweden)

Romain Rouet

2018-02-01

Full Text Available In vitro selection technology has transformed the development of therapeutic monoclonal antibodies. Using methods such as phage, ribosome, and yeast display, high affinity binders can be selected from diverse repertoires. Here, we review strategies for the next-generation sequencing (NGS of phage- and other antibody-display libraries, as well as NGS platforms and analysis tools. Moreover, we discuss recent examples relating to the use of NGS to assess library diversity, clonal enrichment, and affinity maturation.

Next-generation digital information storage in DNA.

Science.gov (United States)

Church, George M; Gao, Yuan; Kosuri, Sriram

2012-09-28

Digital information is accumulating at an astounding rate, straining our ability to store and archive it. DNA is among the most dense and stable information media known. The development of new technologies in both DNA synthesis and sequencing make DNA an increasingly feasible digital storage medium. We developed a strategy to encode arbitrary digital information in DNA, wrote a 5.27-megabit book using DNA microchips, and read the book by using next-generation DNA sequencing.

Popular Imagination and Identity Politics: Reading the Future in "Star Trek: The Next Generation."

Science.gov (United States)

Ott, Brian L.; Aoki, Eric

2001-01-01

Analyzes the television series "Star Trek: The Next Generation." Theorizes the relationship between collective visions of the future and the identity politics of the present. Argues that "The Next Generation" invites audiences to participate in a shared sense of the future that constrains human agency and (re)produces the…

Next Generation Life Support (NGLS): Rapid Cycle Amine Swing Bed

Data.gov (United States)

National Aeronautics and Space Administration — The Rapid Cycle Amine (RCA) swingbed has been identified as a technology with high potential to meet the stringent requirements for the next generation spacesuit's...

Modelling of control system architecture for next-generation accelerators

International Nuclear Information System (INIS)

Liu, Shi-Yao; Kurokawa, Shin-ichi

1990-01-01

Functional, hardware and software system architectures define the fundamental structure of control systems. Modelling is a protocol of system architecture used in system design. This paper reviews various modellings adopted in past ten years and suggests a new modelling for next generation accelerators. (author)

Next Generation UV Coronagraph Instrumentation for Solar Cycle-24

Indian Academy of Sciences (India)

2016-01-27

Jan 27, 2016 ... New concepts for next generation instrumentation include imaging ultraviolet spectrocoronagraphs and large aperture ultraviolet coronagraph spectrometers. An imaging instrument would be the first to obtain absolute spectral line intensities of the extended corona over a wide field of view. Such images ...

Power Electronics for the Next Generation Wind Turbine System

DEFF Research Database (Denmark)

Ma, Ke

This book presents recent studies on the power electronics used for the next generation wind turbine system. Some criteria and tools for evaluating and improving the critical performances of the wind power converters have been proposed and established. The book addresses some emerging problems...

Development of a framework for the neutronics analysis system for next generation (3)

International Nuclear Information System (INIS)

Yokoyama, Kenji; Hirai, Yasushi; Hyoudou, Hideaki; Tatsumi, Masahiro

2010-02-01

Development of innovative analysis methods and models in fundamental studies for next-generation nuclear reactor systems is in progress. In order to efficiently and effectively reflect the latest analysis methods and models to primary design of commercial reactor and/or in-core fuel management for power reactors, a next-generation analysis system MARBLE has been developed. The next-generation analysis system provides solutions to the following requirements: (1) flexibility, extensibility and user-friendliness that can apply new methods and models rapidly and effectively for fundamental studies, (2) quantitative proof of solution accuracy and adaptive scoping range for design studies, (3) coupling analysis among different study domains for the purpose of rationalization of plant systems and improvement of reliability, (4) maintainability and reusability for system extensions for the purpose of total quality management and development efficiency. The next-generation analysis system supports many fields, such as thermal-hydraulic analysis, structure analysis, reactor physics etc., and now we are studying reactor physics analysis system for fast reactor in advance. As for reactor physics analysis methods for fast reactor, we have established the JUPITER standard analysis methods based on the past study. But, there has been a problem of extreme inefficiency due to lack of functionality in the conventional analysis system when changing analysis targets and/or modeling levels. That is why, we have developed the next-generation analysis system for reactor physics which reproduces the JUPITER standard analysis method that has been developed so far and newly realizes burnup and design analysis for fast reactor and functions for cross section adjustment. In the present study, we examined in detail the existing design and implementation of ZPPR critical experiment analysis database followed by unification of models within the framework of the next-generation analysis system by

Validation and Adaptation of Router and Switch Models

NARCIS (Netherlands)

Boltjes, B.; Fernandez Diaz, I.; Kock, B.A.; Langeveld, R.J.G.M.; Schoenmaker, G.

2003-01-01

This paper describes validating OPNET models of key devices for the next generation IP-based tactical network of the Royal Netherlands Army (RNLA). The task of TNO-FEL is to provide insight in scalability and performance of future deployed networks. Because validated models ol key Cisco equipment

Next-generation Sequencing-based genomic profiling: Fostering innovation in cancer care?

Directory of Open Access Journals (Sweden)

Gustavo S. Fernandes

Full Text Available OBJECTIVES: With the development of next-generation sequencing (NGS technologies, DNA sequencing has been increasingly utilized in clinical practice. Our goal was to investigate the impact of genomic evaluation on treatment decisions for heavily pretreated patients with metastatic cancer. METHODS: We analyzed metastatic cancer patients from a single institution whose cancers had progressed after all available standard-of-care therapies and whose tumors underwent next-generation sequencing analysis. We determined the percentage of patients who received any therapy directed by the test, and its efficacy. RESULTS: From July 2013 to December 2015, 185 consecutive patients were tested using a commercially available next-generation sequencing-based test, and 157 patients were eligible. Sixty-six patients (42.0% were female, and 91 (58.0% were male. The mean age at diagnosis was 52.2 years, and the mean number of pre-test lines of systemic treatment was 2.7. One hundred and seventy-seven patients (95.6% had at least one identified gene alteration. Twenty-four patients (15.2% underwent systemic treatment directed by the test result. Of these, one patient had a complete response, four (16.7% had partial responses, two (8.3% had stable disease, and 17 (70.8% had disease progression as the best result. The median progression-free survival time with matched therapy was 1.6 months, and the median overall survival was 10 months. CONCLUSION: We identified a high prevalence of gene alterations using an next-generation sequencing test. Although some benefit was associated with the matched therapy, most of the patients had disease progression as the best response, indicating the limited biological potential and unclear clinical relevance of this practice.

Developing the next generation of nuclear workers at OPG

International Nuclear Information System (INIS)

Spekkens, P.

2007-01-01

This presentation is about developing the next generation of nuclear workers at Ontario Power Generation (OPG). Industry developments are creating urgent need to hire, train and retain new staff. OPG has an aggressive hiring campaign. Training organization is challenged to accommodate influx of new staff. Collaborating with colleges and universities is increasing the supply of qualified recruits with an interest in nuclear. Program for functional and leadership training have been developed. Knowledge retention is urgently required

Heterogeneous next-generation wireless network interference model-and its applications

KAUST Repository

Mahmood, Nurul Huda; Yilmaz, Ferkan; Alouini, Mohamed-Slim; Ø ien, Geir Egil

2014-01-01

Next-generation wireless systems facilitating better utilisation of the scarce radio spectrum have emerged as a response to inefficient and rigid spectrum assignment policies. These are comprised of intelligent radio nodes that opportunistically

Epidemiological Studies to Support the Development of Next Generation Influenza Vaccines.

Science.gov (United States)

Petrie, Joshua G; Gordon, Aubree

2018-03-26

The National Institute of Allergy and Infectious Diseases recently published a strategic plan for the development of a universal influenza vaccine. This plan focuses on improving understanding of influenza infection, the development of influenza immunity, and rational design of new vaccines. Epidemiological studies such as prospective, longitudinal cohort studies are essential to the completion of these objectives. In this review, we discuss the contributions of epidemiological studies to our current knowledge of vaccines and correlates of immunity, and how they can contribute to the development and evaluation of the next generation of influenza vaccines. These studies have been critical in monitoring the effectiveness of current influenza vaccines, identifying issues such as low vaccine effectiveness, reduced effectiveness among those who receive repeated vaccination, and issues related to egg adaptation during the manufacturing process. Epidemiological studies have also identified population-level correlates of protection that can inform the design and development of next generation influenza vaccines. Going forward, there is an enduring need for epidemiological studies to continue advancing knowledge of correlates of protection and the development of immunity, to evaluate and monitor the effectiveness of next generation influenza vaccines, and to inform recommendations for their use.

Next generation multi-material 3D food printer concept

NARCIS (Netherlands)

Klomp, D.J.; Anderson, P.D.

2017-01-01

3D food printing is a new rapidly developing technology capable of creating food structures that are impossible to create with normal processing techniques. Challenges in this field are creating texture and multi-material food products. To address these challenges a next generation food printer will

Next-generation sequencing approaches to understanding the oral microbiome

NARCIS (Netherlands)

Zaura, E.

2012-01-01

Until recently, the focus in dental research has been on studying a small fraction of the oral microbiome—so-called opportunistic pathogens. With the advent of next-generation sequencing (NGS) technologies, researchers now have the tools that allow for profiling of the microbiomes and metagenomes at

Big Data Perspective and Challenges in Next Generation Networks

Directory of Open Access Journals (Sweden)

Kashif Sultan

2018-06-01

Full Text Available With the development towards the next generation cellular networks, i.e., 5G, the focus has shifted towards meeting the higher data rate requirements, potential of micro cells and millimeter wave spectrum. The goals for next generation networks are very high data rates, low latency and handling of big data. The achievement of these goals definitely require newer architecture designs, upgraded technologies with possible backward support, better security algorithms and intelligent decision making capability. In this survey, we identify the opportunities which can be provided by 5G networks and discuss the underlying challenges towards implementation and realization of the goals of 5G. This survey also provides a discussion on the recent developments made towards standardization, the architectures which may be potential candidates for deployment and the energy concerns in 5G networks. Finally, the paper presents a big data perspective and the potential of machine learning for optimization and decision making in 5G networks.

Recent progress in nanostructured next-generation field emission devices

International Nuclear Information System (INIS)

Mittal, Gaurav; Lahiri, Indranil

2014-01-01

Field emission has been known to mankind for more than a century, and extensive research in this field for the last 40–50 years has led to development of exciting applications such as electron sources, miniature x-ray devices, display materials, etc. In the last decade, large-area field emitters were projected as an important material to revolutionize healthcare and medical devices, and space research. With the advent of nanotechnology and advancements related to carbon nanotubes, field emitters are demonstrating highly enhanced performance and novel applications. Next-generation emitters need ultra-high emission current density, high brightness, excellent stability and reproducible performance. Novel design considerations and application of new materials can lead to achievement of these capabilities. This article presents an overview of recent developments in this field and their effects on improved performance of field emitters. These advancements are demonstrated to hold great potential for application in next-generation field emission devices. (topical review)

Recent progress in nanostructured next-generation field emission devices

Science.gov (United States)

Mittal, Gaurav; Lahiri, Indranil

2014-08-01

Field emission has been known to mankind for more than a century, and extensive research in this field for the last 40-50 years has led to development of exciting applications such as electron sources, miniature x-ray devices, display materials, etc. In the last decade, large-area field emitters were projected as an important material to revolutionize healthcare and medical devices, and space research. With the advent of nanotechnology and advancements related to carbon nanotubes, field emitters are demonstrating highly enhanced performance and novel applications. Next-generation emitters need ultra-high emission current density, high brightness, excellent stability and reproducible performance. Novel design considerations and application of new materials can lead to achievement of these capabilities. This article presents an overview of recent developments in this field and their effects on improved performance of field emitters. These advancements are demonstrated to hold great potential for application in next-generation field emission devices.

Carrier ethernet network control plane based on the Next Generation Network

DEFF Research Database (Denmark)

Fu, Rong; Wang, Yanmeng; Berger, Michael Stubert

2008-01-01

This paper contributes on presenting a step towards the realization of Carrier Ethernet control plane based on the next generation network (NGN). Specifically, transport MPLS (T-MPLS) is taken as the transport technology in Carrier Ethernet. It begins with providing an overview of the evolving...... architecture of the next generation network (NGN). As an essential candidate among the NGN transport technologies, the definition of Carrier Ethernet (CE) is also introduced here. The second part of this paper depicts the contribution on the T-MPLS based Carrier Ethernet network with control plane based on NGN...... at illustrating the improvement of the Carrier Ethernet network with the NGN control plane....

Development of source term evaluation method for Korean Next Generation Reactor

Energy Technology Data Exchange (ETDEWEB)

Lee, Keon Jae; Cheong, Jae Hak; Park, Jin Baek; Kim, Guk Gee [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

1997-10-15

This project had investigate several design features of radioactive waste processing system and method to predict nuclide concentration at primary coolant basic concept of next generation reactor and safety goals at the former phase. In this project several prediction methods of source term are evaluated conglomerately and detailed contents of this project are : model evaluation of nuclide concentration at Reactor Coolant System, evaluation of primary and secondary coolant concentration of reference Nuclear Power Plant(NPP), investigation of prediction parameter of source term evaluation, basic parameter of PWR, operational parameter, respectively, radionuclide removal system and adjustment values of reference NPP, suggestion of source term prediction method of next generation NPP.

Next generation of relativistic heavy ion accelerators

International Nuclear Information System (INIS)

Grunder, H.; Leemann, C.; Selph, F.

1978-06-01

Results are presented of exploratory and preliminary studies of a next generation of heavy ion accelerators. The conclusion is reached that useful luminosities are feasible in a colliding beam facility for relativistic heavy ions. Such an accelerator complex may be laid out in such a way as to provide extractebeams for fixed target operation, therefore allowing experimentation in an energy region overlapping with that presently available. These dual goals seem achievable without undue complications, or penalties with respect to cost and/or performance

Thermonuclear ignition in the next generation tokamaks

International Nuclear Information System (INIS)

Johner, J.

1989-04-01

The extrapolation of experimental rules describing energy confinement and magnetohydrodynamic - stability limits, in known tokamaks, allow to show that stable thermonuclear ignition equilibria should exist in this configuration, if the product aB t x of the dimensions by a magnetic-field power is large enough. Quantitative application of this result to several next-generation tokamak projects show that those kinds of equilibria could exist in such devices, which would also have enough additional heating power to promote an effective accessible ignition

Next Generation Antibody Therapeutics Using Bispecific Antibody Technology.

Science.gov (United States)

Igawa, Tomoyuki

2017-01-01

Nearly fifty monoclonal antibodies have been approved to date, and the market for monoclonal antibodies is expected to continue to grow. Since global competition in the field of antibody therapeutics is intense, we need to establish novel antibody engineering technologies to provide true benefit for patients, with differentiated product values. Bispecific antibodies are among the next generation of antibody therapeutics that can bind to two different target antigens by the two arms of immunoglobulin G (IgG) molecule, and are thus believed to be applicable to various therapeutic needs. Until recently, large scale manufacturing of human IgG bispecific antibody was impossible. We have established a technology, named asymmetric re-engineering technology (ART)-Ig, to enable large scale manufacturing of bispecific antibodies. Three examples of next generation antibody therapeutics using ART-Ig technology are described. Recent updates on bispecific antibodies against factor IXa and factor X for the treatment of hemophilia A, bispecific antibodies against a tumor specific antigen and T cell surface marker CD3 for cancer immunotherapy, and bispecific antibodies against two different epitopes of soluble antigen with pH-dependent binding property for the elimination of soluble antigen from plasma are also described.

Feasibility and application on steam injector for next-generation reactor

International Nuclear Information System (INIS)

Narabayashi, Tadashi; Ishiyama, Takenori; Miyano, Hiroshi; Nei, Hiromichi; Shioiri, Akio

1991-01-01

A feasibility study has been conducted on steam injector for a next generation reactor. The steam injector is a simple, compact passive device for water injection, such as Passive Core Injection System (PCIS) of Passive Containment Cooling System (PCCS), because of easy start-up without an AC power. An analysis model for a steam injector characteristics has been developed, and investigated with a visualized fundamental test for a two-stage Steam Injector System (SIS) for PCIS and a one-stage low pressure SIS for PCCS. The test results showed good agreement with the analysis results. The analysis and the test results showed the SIS could work over a very wide range of the steam pressure, and is applicable for PCIS or PCCS in the next generation reactors. (author)

Results of Analyses of the Next Generation Solvent for Parsons

International Nuclear Information System (INIS)

Peters, T.; Washington, A.; Fink, S.

2012-01-01

Savannah River National Laboratory (SRNL) prepared a nominal 150 gallon batch of Next Generation Solvent (NGS) for Parsons. This material was then analyzed and tested for cesium mass transfer efficiency. The bulk of the results indicate that the solvent is qualified as acceptable for use in the upcoming pilot-scale testing at Parsons Technology Center. This report describes the analysis and testing of a batch of Next Generation Solvent (NGS) prepared in support of pilot-scale testing in the Parsons Technology Center. A total of ∼150 gallons of NGS solvent was prepared in late November of 2011. Details for the work are contained in a controlled laboratory notebook. Analysis of the Parsons NGS solvent indicates that the material is acceptable for use. SRNL is continuing to improve the analytical method for the guanidine.

Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data

NARCIS (Netherlands)

K.M. Hettne (Kristina); J. Boorsma (Jeffrey); D.A.M. van Dartel (Dorien A M); J.J. Goeman (Jelle); E.C. de Jong (Esther); A.H. Piersma (Aldert); R.H. Stierum (Rob); J. Kleinjans (Jos); J.A. Kors (Jan)

2013-01-01

textabstractBackground: Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-generation text mining (next-gen TM), and that these can be used with

The "Next Generation Science Standards" and the Life Sciences

Science.gov (United States)

Bybee, Rodger W.

2013-01-01

Publication of the "Next Generation Science Standards" will be just short of two decades since publication of the "National Science Education Standards" (NRC 1996). In that time, biology and science education communities have advanced, and the new standards will reflect that progress (NRC 1999, 2007, 2009; Kress and Barrett…

Electric vehicle charge patterns and the electricity generation mix and competitiveness of next generation vehicles

International Nuclear Information System (INIS)

Masuta, Taisuke; Murata, Akinobu; Endo, Eiichi

2014-01-01

Highlights: • The energy system of whole of Japan is analyzed in this study. • An advanced model based on MARKAL is used for the energy system analysis. • The impact of charge patterns of EVs on electricity generation mix is evaluated. • Technology competitiveness of the next generation vehicles is also evaluated. - Abstract: The nuclear accident of 2011 brought about a reconsideration of the future electricity generation mix of power systems in Japan. A debate on whether to phase out nuclear power plants and replace them with renewable energy sources is taking place. Demand-side management becomes increasingly important in future Japanese power systems with a large-scale integration of renewable energy sources. This paper considers the charge control of electric vehicles (EVs) through demand-side management. There have been many studies of the control or operation methods of EVs known as vehicle-to-grid (V2G), and it is important to evaluate both their short-term and long-term operation. In this study, we employ energy system to evaluate the impact of the charge patterns of EVs on both the electricity generation mix and the technology competitiveness of the next generation vehicles. An advanced energy system model based on Market Allocation (MARKAL) is used to consider power system control in detail

Genetic Variation in the ND1 Gene and D-loop in Protected and Commercially Exploited European Cisco (Coregonus albula L.) Populations.

Science.gov (United States)

Kirczuk, Lucyna; Rymaszewska, Anna; Pilecka-Rapacz, Malgorzata; Domagala, Jozef

The European cisco (Coregonus albula L.) is a species with high environmental requirements. The deterioration of environmental conditions in recent decades has decreased its distribution. Currently the species is conserved by stocking, and the few existing natural populations are at risk of extinction. Therefore, contemporary studies involve not only reporting phenotypic parameters, but also determining the genetic structure of the population. This is an important aspect monitored in the C. albula population, which provides information valuable for proper fishing economy. This study included valuable populations from lakes located in Drawa National Park (DNP) and Wigry National Park (WNP), as well as lakes used for commercial fishing. In order to molecularly characterize the European cisco, the control region and NDl gene were sequenced from 48 individuals from 9 populations from lakes throughout northern Poland. Analysis revealed that populations from two park lakes (Marta, Ostrowieckie) are unique. This was also the case for some sequences originating from Lake Wigry. The mean value of genetic diversity was 0.2% within each region and 0.1-0.3% between the investigated regions. The obtained results demonstrated the necessity to strengthen and protect natural populations of the European cisco, which constitute a valuable element of the European ichthyofauna.

User-Generated Social Media Events in Tourism

Directory of Open Access Journals (Sweden)

Estela Marine-Roig

2017-12-01

Full Text Available Social media and mobile technologies have revolutionised communication and particular attention has been given to user-generated content (UGC and the formation of online communities; however, little attention has been given to tourist events entirely generated by users through social media. This paper aims to define and characterise the phenomenon of tourism user-generated events (UGEs through social media around the user’s new empowered role and to assess user-generated social media events’ online socialness. It is also our aim to provide a useful mixed-methodology analysis framework for UGEs in relation to social media and to highlight their interest for organisations. The methodological approach includes a quantitative model to store, analyse and compare events’ online socialness, which is combined with qualitative, participant observation at the events. This approach is applied to the analysis of three Instagram meetups organised by a specific online community at Catalan ski resorts. The paper’s results show the differential characteristic of tourism UGEs: user initiative and empowerment, full organisation and structure, great social media use and UGC production, brand dissemination, attraction capacity, strong online community bond and faithfulness. With UGEs, an event management paradigm shift occurs as organisations are no longer the main initiators and controllers of the event.

Modeling the video distribution link in the Next Generation Optical Access Networks

International Nuclear Information System (INIS)

Amaya, F; Cardenas, A; Tafur, I

2011-01-01

In this work we present a model for the design and optimization of the video distribution link in the next generation optical access network. We analyze the video distribution performance in a SCM-WDM link, including the noise, the distortion and the fiber optic nonlinearities. Additionally, we consider in the model the effect of distributed Raman amplification, used to extent the capacity and the reach of the optical link. In the model, we use the nonlinear Schroedinger equation with the purpose to obtain capacity limitations and design constrains of the next generation optical access networks.

The study of methodologies of software development for the next generation of HEP detector software

International Nuclear Information System (INIS)

Ding Yuzheng; Wang Taijie; Dai Guiliang

1997-01-01

The author discusses the characteristics of the next generation of HEP (High Energy Physics) detector software, and describes the basic strategy for the usage of object oriented methodologies, languages and tools in the development of the next generation of HEP detector software

Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data

NARCIS (Netherlands)

Hettne, K.M.; Boorsma, A.; Dartel, D.A. van; Goeman, J.J.; Jong, E. de; Piersma, A.H.; Stierum, R.H.; Kleinjans, J.C.; Kors, J.A.

2013-01-01

BACKGROUND: Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-generation text mining (next-gen TM), and that these can be used with gene set

Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data

NARCIS (Netherlands)

Hettne, K.M.; Boorsma, A.; Dartel, van D.A.M.; Goeman, J.J.; Jong, de E.; Piersma, A.H.; Stierum, R.H.; Kleinjans, J.C.; Kors, J.A.

2013-01-01

Background: Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-generation text mining (next-gen TM), and that these can be used with gene set

Multiple Access Techniques for Next Generation Wireless: Recent Advances and Future Perspectives

Directory of Open Access Journals (Sweden)

Shree Krishna Sharma

2016-01-01

Full Text Available The advances in multiple access techniques has been one of the key drivers in moving from one cellular generation to another. Starting from the first generation, several multiple access techniques have been explored in different generations and various emerging multiplexing/multiple access techniques are being investigated for the next generation of cellular networks. In this context, this paper first provides a detailed review on the existing Space Division Multiple Access (SDMA related works. Subsequently, it highlights the main features and the drawbacks of various existing and emerging multiplexing/multiple access techniques. Finally, we propose a novel concept of clustered orthogonal signature division multiple access for the next generation of cellular networks. The proposed concept envisions to employ joint antenna coding in order to enhance the orthogonality of SDMA beams with the objective of enhancing the spectral efficiency of future cellular networks.

Next generation science standards available for comment

Science.gov (United States)

Asher, Pranoti

2012-05-01

The first public draft of the Next Generation Science Standards (NGSS) is now available for public comment. Feedback on the standards is sought from people who have a stake in science education, including individuals in the K-12, higher education, business, and research communities. Development of NGSS is a state-led effort to define the content and practices students need to learn from kindergarten through high school. NGSS will be based on the U.S. National Research Council's reportFramework for K-12 Science Education.

Event generators in particle physics

International Nuclear Information System (INIS)

Sjostrand, Torbjorn

1994-01-01

This presentation gives an introduction to the topic of event generators in particle physics . The emphasis is on the physics aspects that have to be considered in the construction of a generator, and what lessons we have learned from comparisons with data. A brief survey of existing generators is also included. As illustration, a few topics of current interest are covered in a bit more detail: QCD uncertainties in W mass determinations and γp/γγ physics. (author)

Design Principles of Next-Generation Digital Gaming for Education.

Science.gov (United States)

Squire, Kurt; Jenkins, Henry; Holland, Walter; Miller, Heather; O'Driscoll, Alice; Tan, Katie Philip; Todd, Katie.

2003-01-01

Discusses the rapid growth of digital games, describes research at MIT that is exploring the potential of digital games for supporting learning, and offers hypotheses about the design of next-generation educational video and computer games. Highlights include simulations and games; and design principles, including context and using information to…

Identification and Characterization of Key Human Performance Issues and Research in the Next Generation Air Transportation System (NextGen)

Science.gov (United States)

Lee, Paul U.; Sheridan, Tom; Poage, james L.; Martin, Lynne Hazel; Jobe, Kimberly K.

2010-01-01

This report identifies key human-performance-related issues associated with Next Generation Air Transportation System (NextGen) research in the NASA NextGen-Airspace Project. Four Research Focus Areas (RFAs) in the NextGen-Airspace Project - namely Separation Assurance (SA), Airspace Super Density Operations (ASDO), Traffic Flow Management (TFM), and Dynamic Airspace Configuration (DAC) - were examined closely. In the course of the research, it was determined that the identified human performance issues needed to be analyzed in the context of NextGen operations rather than through basic human factors research. The main gaps in human factors research in NextGen were found in the need for accurate identification of key human-systems related issues within the context of specific NextGen concepts and better design of the operational requirements for those concepts. By focusing on human-system related issues for individual concepts, key human performance issues for the four RFAs were identified and described in this report. In addition, mixed equipage airspace with components of two RFAs were characterized to illustrate potential human performance issues that arise from the integration of multiple concepts.

75 FR 82387 - Next Generation Risk Assessment Public Dialogue Conference

Science.gov (United States)

2010-12-30

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9246-7] Next Generation Risk Assessment Public Dialogue Conference AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of Public Dialogue Conference... methods with the National Institutes of Environmental Health Sciences' National Toxicology Program, Center...

Quantitative miRNA expression analysis: comparing microarrays with next-generation sequencing

DEFF Research Database (Denmark)

Willenbrock, Hanni; Salomon, Jesper; Søkilde, Rolf

2009-01-01

Recently, next-generation sequencing has been introduced as a promising, new platform for assessing the copy number of transcripts, while the existing microarray technology is considered less reliable for absolute, quantitative expression measurements. Nonetheless, so far, results from the two...... technologies have only been compared based on biological data, leading to the conclusion that, although they are somewhat correlated, expression values differ significantly. Here, we use synthetic RNA samples, resembling human microRNA samples, to find that microarray expression measures actually correlate...... better with sample RNA content than expression measures obtained from sequencing data. In addition, microarrays appear highly sensitive and perform equivalently to next-generation sequencing in terms of reproducibility and relative ratio quantification....

RIPng- A next Generation Routing Protocal (IPv6) | Falaye | Journal ...

African Journals Online (AJOL)

... Information Protocol Next Generation (RIPng) owing to the current depletion rate of IPv4. ... that support the Internet Protocol Version 6 (IPv6).addressing scheme. ... A brief history is given; its various versions are discussed, and detailed ...

Clinical utility of a 377 gene custom next-generation sequencing ...

Indian Academy of Sciences (India)

JEN BEVILACQUA

2017-07-26

Jul 26, 2017 ... Clinical utility of a 377 gene custom next-generation sequencing epilepsy panel ... number of genes, making it a very attractive option for a condition as .... clinical value of various test offerings to guide decision making.

AgMIP: Next Generation Models and Assessments

Science.gov (United States)

Rosenzweig, C.

2014-12-01

Next steps in developing next-generation crop models fall into several categories: significant improvements in simulation of important crop processes and responses to stress; extension from simplified crop models to complex cropping systems models; and scaling up from site-based models to landscape, national, continental, and global scales. Crop processes that require major leaps in understanding and simulation in order to narrow uncertainties around how crops will respond to changing atmospheric conditions include genetics; carbon, temperature, water, and nitrogen; ozone; and nutrition. The field of crop modeling has been built on a single crop-by-crop approach. It is now time to create a new paradigm, moving from 'crop' to 'cropping system.' A first step is to set up the simulation technology so that modelers can rapidly incorporate multiple crops within fields, and multiple crops over time. Then the response of these more complex cropping systems can be tested under different sustainable intensification management strategies utilizing the updated simulation environments. Model improvements for diseases, pests, and weeds include developing process-based models for important diseases, frameworks for coupling air-borne diseases to crop models, gathering significantly more data on crop impacts, and enabling the evaluation of pest management strategies. Most smallholder farming in the world involves integrated crop-livestock systems that cannot be represented by crop modeling alone. Thus, next-generation cropping system models need to include key linkages to livestock. Livestock linkages to be incorporated include growth and productivity models for grasslands and rangelands as well as the usual annual crops. There are several approaches for scaling up, including use of gridded models and development of simpler quasi-empirical models for landscape-scale analysis. On the assessment side, AgMIP is leading a community process for coordinated contributions to IPCC AR6

The Next Generation Science Standards: The Features and Challenges

Science.gov (United States)

Pruitt, Stephen L.

2014-01-01

Beginning in January of 2010, the Carnegie Corporation of New York funded a two-step process to develop a new set of state developed science standards intended to prepare students for college and career readiness in science. These new internationally benchmarked science standards, the Next Generation Science Standards (NGSS) were completed in…

Career Advancement: Meeting the Challenges Confronting the Next Generation of Endocrinologists and Endocrine Researchers.

Science.gov (United States)

Santen, Richard J; Joham, Anju; Fishbein, Lauren; Vella, Kristen R; Ebeling, Peter R; Gibson-Helm, Melanie; Teede, Helena

2016-12-01

Challenges and opportunities face the next generation (Next-Gen) of endocrine researchers and clinicians, the lifeblood of the field of endocrinology for the future. A symposium jointly sponsored by The Endocrine Society and the Endocrine Society of Australia was convened to discuss approaches to addressing the present and future Next-Gen needs. Data collection by literature review, assessment of previously completed questionnaires, commissioning of a new questionnaire, and summarization of symposium discussions were studied. Next-Gen endocrine researchers face diminishing grant funding in inflation-adjusted terms. The average age of individuals being awarded their first independent investigator funding has increased to age 45 years. For clinicians, a workforce gap exists between endocrinologists needed and those currently trained. Clinicians in practice are increasingly becoming employees of integrated hospital systems, resulting in greater time spent on nonclinical issues. Workforce data and published reviews identify challenges specifically related to early career women in endocrinology. Strategies to Address Issues: Recommendations encompassed the areas of grant support for research, mentoring, education, templates for career development, specific programs for Next-Gen members by senior colleagues as outlined in the text, networking, team science, and life/work integration. Endocrine societies focusing on Next-Gen members provide a powerful mechanism to support these critical areas. A concerted effort to empower, train, and support the next generation of clinical endocrinologists and endocrine researchers is necessary to ensure the viability and vibrancy of our discipline and to optimize our contributions to improving health outcomes. Collaborative engagement of endocrine societies globally will be necessary to support our next generation moving forward.

"ASTRO 101" Course Materials 2.0: Next Generation Lecture Tutorials and Beyond

Science.gov (United States)

Slater, Stephanie; Grazier, Kevin

2015-01-01

Early efforts to create course materials were often local in scale and were based on "gut instinct," and classroom experience and observation. While subsequent efforts were often based on those same instincts and observations of classrooms, they also incorporated the results of many years of education research. These "second generation" course materials, such as lecture tutorials, relied heavily on research indicating that instructors need to actively engage students in the learning process. While imperfect, these curricular innovations, have provided evidence that research-based materials can be constructed, can easily be disseminated to a broad audience, and can provide measureable improvement in student learning across many settings. In order to improve upon this prior work, next generation materials must build upon the strengths of these innovations while engineering in findings from education research, cognitive science, and instructor feedback. A next wave of materials, including a set of next generation lecture tutorials, have been constructed with attention to the body of research on student motivation, and cognitive load; and they are responsive to our body of knowledge on learning difficulties related to specific content in the domain. From instructor feedback, these materials have been constructed to have broader coverage of the materials typically taught in an ASTRO 101 course, to take less class time, and to be more affordable for students. This next generation of lecture tutorials may serve as a template of the ways in which course materials can be reengineered to respond to current instructor and student needs.

Next generation Zero-Code control system UI

CERN Multimedia

CERN. Geneva

2017-01-01

Developing ergonomic user interfaces for control systems is challenging, especially during machine upgrade and commissioning where several small changes may suddenly be required. Zero-code systems, such as *Inspector*, provide agile features for creating and maintaining control system interfaces. More so, these next generation Zero-code systems bring simplicity and uniformity and brake the boundaries between Users and Developers. In this talk we present *Inspector*, a CERN made Zero-code application development system, and we introduce the major differences and advantages of using Zero-code control systems to develop operational UI.

Beamstrahlung spectra in next generation linear colliders

Energy Technology Data Exchange (ETDEWEB)

Barklow, T.; Chen, P. (Stanford Linear Accelerator Center, Menlo Park, CA (United States)); Kozanecki, W. (DAPNIA-SPP, CEN-Saclay (France))

1992-04-01

For the next generation of linear colliders, the energy loss due to beamstrahlung during the collision of the e{sup +}e{sup {minus}} beams is expected to substantially influence the effective center-of-mass energy distribution of the colliding particles. In this paper, we first derive analytical formulae for the electron and photon energy spectra under multiple beamstrahlung processes, and for the e{sup +}e{sup {minus}} and {gamma}{gamma} differential luminosities. We then apply our formulation to various classes of 500 GeV e{sup +}e{sup {minus}} linear collider designs currently under study.

Thermal management of next-generation contact-cooled synchrotron x-ray mirrors

Energy Technology Data Exchange (ETDEWEB)

Khounsary, A.

1999-10-29

In the past decade, several third-generation synchrotrons x-ray sources have been constructed and commissioned around the world. Many of the major problems in the development and design of the optical components capable of handling the extremely high heat loads of the generated x-ray beams have been resolved. It is expected, however, that in the next few years even more powerful x-ray beams will be produced at these facilities, for example, by increasing the particle beam current. In this paper, the design of a next generation of synchrotron x-ray mirrors is discussed. The author shows that the design of contact-cooled mirrors capable of handing x-ray beam heat fluxes in excess of 500 W/mm{sup 2} - or more than three times the present level - is well within reach, and the limiting factor is the thermal stress rather then thermally induced slope error.

Educating the next generation of atmospheric scientists within a European Network of Excellence

Science.gov (United States)

Schuepbach, E.; Uherek, E.; Ladstätter-Weissenmayer, A.; Jacob, M. J.

In order to promote the next generation of atmospheric scientists, the task Training and Education (T&E) in ACCENT, the European Network of Excellence in Atmospheric Composition Change ( www.accent-network.org) has developed and implemented an Integrated Learning Environment (ILE). For school teachers and their students, the Internet-based "Global Change Magazine" provides up-to-date and freely accessible scientific material in English and five other languages. Additionally, T&E has produced online teaching material for early-career scientists. These e-learning modules are now being used in University Master's courses across Europe. T&E also organised training events for early-career scientists, combining scientific content with development in transferable skills, to focus on interdisciplinary collaboration, interaction with senior scientists, communication with stakeholders, and dissemination to the general public. Evaluation based on participant feedback evidences the effectiveness of these events, e.g., in terms of motivation to remain in the field. Methodologies and materials from T&E are being published in a Handbook on Best Practice, intended for both educators and scientists around the globe who are involved in education in the field of air quality and climate change science.

Proceedings of the international workshop on next-generation linear colliders

International Nuclear Information System (INIS)

Riordan, M.

1988-12-01

This report contains papers on the next-generation of linear colliders. The particular areas of discussion are: parameters; beam dynamics and wakefields; damping rings and sources; rf power sources; accelerator structures; instrumentation; final focus; and review of beam-beam interaction

C-Arc: A Novel Architecture for Next Generation Context- Aware ...

African Journals Online (AJOL)

In this paper, the common architecture principles of context-aware systems are presented and the crucial contextaware architecture issues to support the next generation context-aware systems which will enable seamless service provisioning in heterogeneous, dynamically varying computing and communication ...

Proceedings of the international workshop on next-generation linear colliders

Energy Technology Data Exchange (ETDEWEB)

Riordan, M. (ed.)

1988-12-01

This report contains papers on the next-generation of linear colliders. The particular areas of discussion are: parameters; beam dynamics and wakefields; damping rings and sources; rf power sources; accelerator structures; instrumentation; final focus; and review of beam-beam interaction.

Next-generation applications in healthcare digital libraries using semantic service composition and coordination.

Science.gov (United States)

Möller, Thorsten; Schuldt, Heiko; Gerber, Andreas; Klusch, Matthias

2006-06-01

Healthcare digital libraries (DLs) increasingly make use of dedicated services to access functionality and/or data. Semantic (web) services enhance single services and facilitate compound services, thereby supporting advanced applications on top of a DL. The traditional process management approach tends to focus on process definition at build time rather than on actual service events in run time, and to anticipate failures in order to define appropriate strategies. This paper presents a novel approach where service coordination is distributed among a set of agents. A dedicated component plans compound semantic services on demand for a particular application. In failure, the planner is reinvoked to define contin- gency strategies. Finally, matchmaking is effected at runtime by choosing the appropriate service provider. These combined technologies will provide key support for highly flexible next-generation DL applications. Such technologies are under development within CASCOM.

Tablet—next generation sequence assembly visualization

Science.gov (United States)

Milne, Iain; Bayer, Micha; Cardle, Linda; Shaw, Paul; Stephen, Gordon; Wright, Frank; Marshall, David

2010-01-01

Summary: Tablet is a lightweight, high-performance graphical viewer for next-generation sequence assemblies and alignments. Supporting a range of input assembly formats, Tablet provides high-quality visualizations showing data in packed or stacked views, allowing instant access and navigation to any region of interest, and whole contig overviews and data summaries. Tablet is both multi-core aware and memory efficient, allowing it to handle assemblies containing millions of reads, even on a 32-bit desktop machine. Availability: Tablet is freely available for Microsoft Windows, Apple Mac OS X, Linux and Solaris. Fully bundled installers can be downloaded from http://bioinf.scri.ac.uk/tablet in 32- and 64-bit versions. Contact: tablet@scri.ac.uk PMID:19965881

Modeling the video distribution link in the Next Generation Optical Access Networks

DEFF Research Database (Denmark)

Amaya, F.; Cárdenas, A.; Tafur Monroy, Idelfonso

2011-01-01

In this work we present a model for the design and optimization of the video distribution link in the next generation optical access network. We analyze the video distribution performance in a SCM-WDM link, including the noise, the distortion and the fiber optic nonlinearities. Additionally, we...... consider in the model the effect of distributed Raman amplification, used to extent the capacity and the reach of the optical link. In the model, we use the nonlinear Schrödinger equation with the purpose to obtain capacity limitations and design constrains of the next generation optical access networks....

NEXT GENERATION TURBINE SYSTEM STUDY

Energy Technology Data Exchange (ETDEWEB)

Frank Macri

2002-02-28

Rolls-Royce has completed a preliminary design and marketing study under a Department of Energy (DOE) cost shared contract (DE-AC26-00NT40852) to analyze the feasibility of developing a clean, high efficiency, and flexible Next Generation Turbine (NGT) system to meet the power generation market needs of the year 2007 and beyond. Rolls-Royce evaluated the full range of its most advanced commercial aerospace and aeroderivative engines alongside the special technologies necessary to achieve the aggressive efficiency, performance, emissions, economic, and flexibility targets desired by the DOE. Heavy emphasis was placed on evaluating the technical risks and the economic viability of various concept and technology options available. This was necessary to ensure the resulting advanced NGT system would provide extensive public benefits and significant customer benefits without introducing unacceptable levels of technical and operational risk that would impair the market acceptance of the resulting product. Two advanced cycle configurations were identified as offering significant advantages over current combined cycle products available in the market. In addition, balance of plant (BOP) technologies, as well as capabilities to improve the reliability, availability, and maintainability (RAM) of industrial gas turbine engines, have been identified. A customer focused survey and economic analysis of a proposed Rolls-Royce NGT product configuration was also accomplished as a part of this research study. The proposed Rolls-Royce NGT solution could offer customers clean, flexible power generation systems with very high efficiencies, similar to combined cycle plants, but at a much lower specific cost, similar to those of simple cycle plants.

Promising Practices: Building the Next Generation of School Leaders

Science.gov (United States)

Bryant, Jennifer Edic; Escalante, Karen; Selva, Ashley

2017-01-01

This study applies transformational leadership theory practices to examine the purposeful ways in which principals work to build the next generation of teacher leaders in response to the shortage of K-12 principals. Given the impact principals have on student development and the shortage of those applying for the principalship, the purpose of this…

Safety reviews of next-generation light-water reactors

International Nuclear Information System (INIS)

Kudrick, J.A.; Wilson, J.N.

1997-01-01

The Nuclear Regulatory Commission (NRC) is reviewing three applications for design certification under its new licensing process. The U.S. Advanced Boiling Water Reactor (ABWR) and System 80+ designs have received final design approvals. The AP600 design review is continuing. The goals of design certification are to achieve early resolution of safety issues and to provide a more stable and predictable licensing process. NRC also reviewed the Utility Requirements Document (URD) of the Electric Power Research Institute (EPRI) and determined that its guidance does not conflict with NRC requirements. This review led to the identification and resolution of many generic safety issues. The NRC determined that next-generation reactor designs should achieve a higher level of safety for selected technical and severe accident issues. Accordingly, NRC developed new review standards for these designs based on (1) operating experience, including the accident at Three Mile Island, Unit 2; (2) the results of probabilistic risk assessments of current and next-generation reactor designs; (3) early efforts on severe accident rulemaking; and (4) research conducted to address previously identified generic safety issues. The additional standards were used during the individual design reviews and the resolutions are documented in the design certification rules. 12 refs

Standardization and quality management in next-generation sequencing.

Science.gov (United States)

Endrullat, Christoph; Glökler, Jörn; Franke, Philipp; Frohme, Marcus

2016-09-01

DNA sequencing continues to evolve quickly even after > 30 years. Many new platforms suddenly appeared and former established systems have vanished in almost the same manner. Since establishment of next-generation sequencing devices, this progress gains momentum due to the continually growing demand for higher throughput, lower costs and better quality of data. In consequence of this rapid development, standardized procedures and data formats as well as comprehensive quality management considerations are still scarce. Here, we listed and summarized current standardization efforts and quality management initiatives from companies, organizations and societies in form of published studies and ongoing projects. These comprise on the one hand quality documentation issues like technical notes, accreditation checklists and guidelines for validation of sequencing workflows. On the other hand, general standard proposals and quality metrics are developed and applied to the sequencing workflow steps with the main focus on upstream processes. Finally, certain standard developments for downstream pipeline data handling, processing and storage are discussed in brief. These standardization approaches represent a first basis for continuing work in order to prospectively implement next-generation sequencing in important areas such as clinical diagnostics, where reliable results and fast processing is crucial. Additionally, these efforts will exert a decisive influence on traceability and reproducibility of sequence data.

Towards Next Generation Internet Management:CNGI-CERNET2EXPERIENCES

Institute of Scientific and Technical Information of China (English)

Jia-Hai Yang; Hui Zhang; Jin-Xiang Zhang; Chang-Qing An

2009-01-01

Manageability is an important feature of next generation Internet; management and monitoring of IPv6-based networks are proving a big challenge. While leveraging current IPv4-based SNMP management scheme to IPv6 networks'management need is necessary, it is more urgent to coin a new network management architecture to accommodate the scalability and extensibility requirements of next generation Internet management. The paper proposes a novel network management architecture, IMN (Internet Management Network), which creates an overlay network of management nodes.While each management node can perform management tasks autonomously and independently, it can finish more sophis-ticated management tasks by collaboratively invoking management operations or sharing information provided by other management nodes. P2P-based communication services are introduced in IMN to enable such collaboration. The paper presents a prototyping implementation based on the Web service related technology, as well as some of the key technologies,especially solutions to those issues arising from the management practice of CERNET2. Experiences of deployment of CERNET2 operation and lessons learned from the management practice are discussed.

Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

Directory of Open Access Journals (Sweden)

Patrice D. Cani

2017-09-01

Full Text Available Metabolic disorders associated with obesity and cardiometabolic disorders are worldwide epidemic. Among the different environmental factors, the gut microbiota is now considered as a key player interfering with energy metabolism and host susceptibility to several non-communicable diseases. Among the next-generation beneficial microbes that have been identified, Akkermansia muciniphila is a promising candidate. Indeed, A. muciniphila is inversely associated with obesity, diabetes, cardiometabolic diseases and low-grade inflammation. Besides the numerous correlations observed, a large body of evidence has demonstrated the causal beneficial impact of this bacterium in a variety of preclinical models. Translating these exciting observations to human would be the next logic step and it now appears that several obstacles that would prevent the use of A. muciniphila administration in humans have been overcome. Moreover, several lines of evidence indicate that pasteurization of A. muciniphila not only increases its stability but more importantly increases its efficacy. This strongly positions A. muciniphila in the forefront of next-generation candidates for developing novel food or pharma supplements with beneficial effects. Finally, a specific protein present on the outer membrane of A. muciniphila, termed Amuc_1100, could be strong candidate for future drug development. In conclusion, as plants and its related knowledge, known as pharmacognosy, have been the source for designing drugs over the last century, we propose that microbes and microbiomegnosy, or knowledge of our gut microbiome, can become a novel source of future therapies.

Next-Generation Ultra-Compact Stowage/Lightweight Solar Array System, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — Deployable Space Systems, Inc. (DSS) has developed a next-generation high performance solar array system that has game-changing performance metrics in terms of...

The Dynamic Pricing of Next Generation Consumer Durables

OpenAIRE

Barry L. Bayus

1992-01-01

Learning curve effects, aspects of consumer demand models (e.g., reservation price distributions, intertemporal utility maximizing behavior), and competitive activity are reasons which have been offered to explain why prices of new durables decline over time. This paper presents an alternative rationale based on the buying behavior for products with overlapping replacement cycles (i.e., next generation products). A model for consumer sales of a new durable is developed by incorporating the re...

Global heterogeneous resource harvesting: the next-generation PanDA Pilot for ATLAS

CERN Document Server

Nilsson, Paul; The ATLAS collaboration

2017-01-01

The Production and Distributed Analysis system (PanDA), used for workload management in the ATLAS Experiment for over a decade, has in recent years expanded its reach to diverse new resource types such as HPCs, and innovative new workflows such as the Event Service. PanDA meets the heterogeneous resources it harvests in the PanDA pilot, which has embarked on a next-generation reengineering to efficiently integrate and exploit the new platforms and workflows. The new modular architecture is the product of a year of design and prototyping in conjunction with the design of a completely new component, Harvester, that will mediate a richer flow of control and information between pilot and PanDA. Harvester will enable more intelligent and dynamic matching between processing tasks and resources, with an initial focus on HPCs, simplifying the operator and user view of a PanDA site but internally leveraging deep information gathering on the resource to accrue detailed knowledge of a site's capabilities and dynamic sta...

Global heterogeneous resource harvesting: the next-generation PanDA pilot for ATLAS

CERN Document Server

Nilsson, Paul; The ATLAS collaboration

2017-01-01

The Production and Distributed Analysis system (PanDA), used for workload management in the ATLAS Experiment for over a decade, has in recent years expanded its reach to diverse new resource types such as HPCs, and innovative new workflows such as the event service. PanDA meets the heterogeneous resources it harvests in the PanDA pilot, which has embarked on a next-generation reengineering to efficiently integrate and exploit the new platforms and workflows. The new modular architecture is the product of a year of design and prototyping in conjunction with the design of a completely new component, Harvester, that will mediate a richer flow of control and information between pilot and PanDA. Harvester will enable more intelligent and dynamic matching between processing tasks and resources, with an initial focus on HPCs, simplifying the operator and user view of a PanDA site but internally leveraging deep information gathering on the resource to accrue detailed knowledge of a site's capabilities and dynamic sta...

On reactor type comparisons for the next generation of reactors

International Nuclear Information System (INIS)

Alesso, H.P.; Majumdar, K.C.

1991-01-01

In this paper, we present a broad comparison of studies for a selected set of parameters for different nuclear reactor types including the next generation. This serves as an overview of key parameters which provide a semi-quantitative decision basis for selecting nuclear strategies. Out of a number of advanced reactor designs of the LWR type, gas cooled type, and FBR type, currently on the drawing board, the Advanced Light Water Reactors (ALWR) seem to have some edge over other types of the next generation of reactors for the near-term application. This is based on a number of attributes related to the benefit of the vast operating experience with LWRs coupled with an estimated low risk profile, economics of scale, degree of utilization of passive systems, simplification in the plant design and layout, modular fabrication and manufacturing. 32 refs., 1 fig., 3 tabs

R&D, Marketing, and the Success of Next-Generation Products

OpenAIRE

Elie Ofek; Miklos Sarvary

2003-01-01

This paper studies dynamic competition in markets characterized by the introduction of technologically advanced next-generation products. Firms invest in new product effort in an attempt to attain industry leadership, thus securing high profits and benefiting from advantages relevant for the success of future product generations. The analysis reveals that when the current leader possesses higher research and development (R&D) competence, it tends to investin R&D than rivals and to retain its ...

Developments of next generation monitor and control systems for radio telescopes

Science.gov (United States)

Kodilkar, J.; Uprade, R.; Nayak, S.; Wadadekar, Y.; Chengalur, J.; Gupta, Y.

2013-04-01

As part of the ongoing upgrade of the GMRT observatory, the monitor and control (M&C) system is being upgraded to a modern specification driven system. The basic building block of the proposed M&C framework is a SACE node which provides command, response and event data streaming interfaces to the child and parent nodes running locally or remotely in a heterogeneous operating system environment. A prototype M&C system formed by hierarchically composing SACE nodes at different levels has been successfully tested at the GMRT. For the recently built 15m antenna at NCRA, a generic, web based M&C system has been developed which allows remote, authenticated operation. We discuss issues relevant to the development of the next generation M&C systems for radio telescopes using the lessons learned from these two systems. We also summarize flexible, reusable and cost-effective approaches using off the shelf packages and technologies used in generic frameworks, which can contribute to form the basis for M&C systems of very large radio telescopes like the SKA.

Developments of next generation monitor and control systems for radio telescopes

International Nuclear Information System (INIS)

Kodilkar, J; Uprade, R; Nayak, S; Wadadekar, Y; Chengalur, J; Gupta, Y

2013-01-01

As part of the ongoing upgrade of the GMRT observatory, the monitor and control (M and C) system is being upgraded to a modern specification driven system. The basic building block of the proposed M and C framework is a SACE node which provides command, response and event data streaming interfaces to the child and parent nodes running locally or remotely in a heterogeneous operating system environment. A prototype M and C system formed by hierarchically composing SACE nodes at different levels has been successfully tested at the GMRT. For the recently built 15m antenna at NCRA, a generic, web based M and C system has been developed which allows remote, authenticated operation. We discuss issues relevant to the development of the next generation M and C systems for radio telescopes using the lessons learned from these two systems. We also summarize flexible, reusable and cost-effective approaches using off the shelf packages and technologies used in generic frameworks, which can contribute to form the basis for M and C systems of very large radio telescopes like the SKA.

Next generation PET data acquisition architectures

Science.gov (United States)

Jones, W. F.; Reed, J. H.; Everman, J. L.; Young, J. W.; Seese, R. D.

1997-06-01

New architectures for higher performance data acquisition in PET are proposed. Improvements are demanded primarily by three areas of advancing PET state of the art. First, larger detector arrays such as the Hammersmith ECAT/sup (R/) EXACT HR/sup ++/ exceed the addressing capacity of 32 bit coincidence event words. Second, better scintillators (LSO) make depth-of interaction (DOI) and time-of-flight (TOF) operation more practical. Third, fully optimized single photon attenuation correction requires higher rates of data collection. New technologies which enable the proposed third generation Real Time Sorter (RTS III) include: (1) 80 Mbyte/sec Fibre Channel RAID disk systems, (2) PowerPC on both VMEbus and PCI Local bus, and (3) quadruple interleaved DRAM controller designs. Data acquisition flexibility is enhanced through a wider 64 bit coincidence event word. PET methodology support includes DOI (6 bits), TOF (6 bits), multiple energy windows (6 bits), 512/spl times/512 sinogram indexes (18 bits), and 256 crystal rings (16 bits). Throughput of 10 M events/sec is expected for list-mode data collection as well as both on-line and replay histogramming. Fully efficient list-mode storage for each PET application is provided by real-time bit packing of only the active event word bits. Real-time circuits provide DOI rebinning.

Next generation PET data acquisition architectures

International Nuclear Information System (INIS)

Jones, W.F.; Reed, J.H.; Everman, J.L.

1996-01-01

New architectures for higher performance data acquisition in PET are proposed. Improvements are demanded primarily by three areas of advancing PET state of the art. First, larger detector arrays such as the Hammersmith ECAT reg-sign EXACT HR ++ exceed the addressing capacity of 32 bit coincidence event words. Second, better scintillators (LSO) make depth-of-interaction (DOI) and time-of-flight (TOF) operation more practical. Third, fully optimized single photon attenuation correction requires higher rates of data collection. New technologies which enable the proposed third generation Real Time Sorter (RTS III) include: (1) 80 M byte/sec Fibre Channel RAID disk systems, (2) PowerPC on both VMEbus and PCI Local bus, and (3) quadruple interleaved DRAM controller designs. Data acquisition flexibility is enhanced through a wider 64 bit coincidence event word. PET methodology support includes DOI (6 bits), TOF (6 bits), multiple energy windows (6 bits), 512 x 512 sinogram indexes (18 bits), and 256 crystal rings (16 bits). Throughput of 10 M events/sec is expected for list-mode data collection as well as both on-line and replay histogramming. Fully efficient list-mode storage for each PET application is provided by real-time bit packing of only the active event word bits. Real-time circuits provide DOI rebinning

Analysis of three cisco forms (Coregonus, Salmonidae) from Lake Saganaga and adjacent lakes near the Minnesota/Ontario border

NARCIS (Netherlands)

Etnier, DA; Skelton, CE

2003-01-01

Based on examination of 655 ciscoes from Lake Saganaga, a Minnesota/Ontario border lake, three forms, about 90% separable on gill raker counts, are present. Form L, with the lowest gill raker counts (26-40, mean = 31.9, n = 96) is tentatively identified as Coregonus zenithicus. Form M, with

Next-Generation Sequencing in Neuropathologic Diagnosis of Infections of the Nervous System (Open Access)

Science.gov (United States)

2016-06-13

nervous system ABSTRACT Objective: To determine the feasibility of next-generation sequencing (NGS) microbiome ap- proaches in the diagnosis of infectious...V, van Doorn HR, Nghia HD, et al. Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections...Kumar, et al. system Next-generation sequencing in neuropathologic diagnosis of infections of the nervous This information is current as of June 13

New ATLAS event generator tunes to 2010 data

CERN Document Server

The ATLAS collaboration

2011-01-01

This note describes the Monte Carlo event generator tunings for the Pythia 6 and Herwig/Jimmy generators in the ATLAS MC11 simulation production. New tunes have been produced for these generators, making maximal use of available published data from ATLAS and from the Tevatron and LEP experiments. Particular emphasis has been placed on improvement of the description of e+ e− event shape and jet rate data, and on description of hadron collider event shape observables in Pythia, as well as the established procedure of tuning the multiple parton interactions of both models to describe underlying event and minimum bias data. The tuning of Pythia is provided at this time for the MRST LO∗∗ PDF, while the purely MPI tune of Herwig/Jimmy is performed for ten different PDFs.

The Monte Carlo event generator DPMJET-III

International Nuclear Information System (INIS)

Roesler, S.; Engel, R.

2001-01-01

A new version of the Monte Carlo event generator DPMJET is presented. It is a code system based on the Dual Parton Model and unifies all features of the DTUNUC-2, DPMJET-II and PHOJET1.12 event generators. DPMJET-III allows the simulation of hadron-hadron, hadron-nucleus, nucleus-nucleus, photon-hadron, photon-photon and photon-nucleus interactions from a few GeV up to the highest cosmic ray energies. (orig.)

Conceptual design of next generation MTR

Energy Technology Data Exchange (ETDEWEB)

Nagata, Hiroshi; Yamaura, Takayuki; Naka, Michihiro; Kawamata, Kazuo; Izumo, Hironobu; Hori, Naohiko; Nagao, Yoshiharu; Kusunoki, Tsuyoshi; Kaminaga, Masanori; Komori, Yoshihiro; Suzuki, Masahide; Kawamura, Hiroshi [Japan Atomic Energy Agency, Oarai Research and Development Center, Oarai, Ibaraki (Japan); Mine, M [Hitachi-GE Nuclear Energy, Ltd., Hitachi, Ibaraki (Japan); Yamazaki, S [Kawasaki Heavy Industries, Ltd., Kobe, Hyogo (Japan); Ishikawa, S [NGK Insulators, Ltd., Nagoya, Aichi (Japan); Miura, K [Sukegawa Electric Co., Ltd., Takahagi, Ibaraki (Japan); Nakashima, S [Fuji Electric Co., Ltd., Tokyo (Japan); Yamaguchi, K [Chiyoda Technol Corp., Tokyo (Japan)

2012-03-15

Conceptual design of the high-performance and low-cost next generation materials testing reactor (MTR) which will be expected to construct in the nuclear power plant introduction countries, started from 2010 in JAEA and nuclear-related companies in Japan. The aims of this conceptual design are to achieve highly safe reactor, economical design, high availability factor and advanced irradiation utilization. One of the basic reactor concept was determined as swimming pool type, thermal power of 10MW and water cooled and moderated reactor with plate type fuel element same as the JMTR. It is expected that the research reactors are used for human resource development, progress of the science and technology, expansion of industry use, lifetime extension of LWRs and so on. (author)

WEAVE: the next generation wide-field spectroscopy facility for the William Herschel Telescope : The next generation wide-field spectroscopy facility for the William Herschel Telescope

NARCIS (Netherlands)

Dalton, Gavin; Trager, Scott C.; Abrams, Don Carlos; Carter, David; Bonifacio, Piercarlo; Aguerri, J. Alfonso L.; MacIntosh, Mike; Evans, Chris; Lewis, Ian; Navarro, Ramon; Agocs, Tibor; Dee, Kevin; Rousset, Sophie; Tosh, Ian; Middleton, Kevin; Pragt, Johannes; Terrett, David; Brock, Matthew; Benn, Chris; Verheijen, Marc; Cano Infantes, Diego; Bevil, Craige; Steele, Iain; Mottram, Chris; Bates, Stuart; Gribbin, Francis J.; Rey, Jürg; Rodriguez, Luis Fernando; Delgado, Jose Miguel; Guinouard, Isabelle; Walton, Nic; Irwin, Michael J.; Jagourel, Pascal; Stuik, Remko; Gerlofsma, Gerrit; Roelfsma, Ronald; Skillen, Ian; Ridings, Andy; Balcells, Marc; Daban, Jean-Baptiste; Gouvret, Carole; Venema, Lars; Girard, Paul

We present the preliminary design of the WEAVE next generation spectroscopy facility for the William Herschel Telescope (WHT), principally targeting optical ground-based follow up of upcoming ground-based (LOFAR) and spacebased (Gaia) surveys. WEAVE is a multi-object and multi-IFU facility utilizing

New long-range speed record with next-generation internet

CERN Multimedia

2003-01-01

"Scientists at CERN and the California Institute of Technology have set a new Internet2 land speed record using the next-generation Internet protocol IPv6. The team sustained a single stream Transfer Control Protocol (TCP) rate of 983 megabits per second for more than one hour between CERN and Chicago, a distance of more than 7,000 kilometres" (1 page).

The construction of next-generation matrices for compartmental epidemic models

NARCIS (Netherlands)

Diekmann, O.|info:eu-repo/dai/nl/071896856; Heesterbeek, J.A.P.|info:eu-repo/dai/nl/073321427; Roberts, M.G.

2010-01-01

The basic reproduction number R0 is arguably the most important quantity in infectious disease epidemiology. The next-generation matrix (NGM) is the natural basis for the definition and calculation of R0 where finitely many different categories of individuals are recognized. We clear up confusion

Impact of ectopic pregnancy for reproductive prognosis in next generation

DEFF Research Database (Denmark)

Kårhus, Line Lund; Egerup, Pia; Skovlund, Charlotte Wessel

2014-01-01

The impact of an ectopic pregnancy in the next generation is unknown. Our aim was to compare reproductive outcomes in daughters of women with and without ectopic pregnancy. Designed as a historical prospective controlled cohort study with data collected in four Danish registries from 1977-2009, w...

Statistical analysis of next generation sequencing data

CERN Document Server

Nettleton, Dan

2014-01-01

Next Generation Sequencing (NGS) is the latest high throughput technology to revolutionize genomic research. NGS generates massive genomic datasets that play a key role in the big data phenomenon that surrounds us today. To extract signals from high-dimensional NGS data and make valid statistical inferences and predictions, novel data analytic and statistical techniques are needed. This book contains 20 chapters written by prominent statisticians working with NGS data. The topics range from basic preprocessing and analysis with NGS data to more complex genomic applications such as copy number variation and isoform expression detection. Research statisticians who want to learn about this growing and exciting area will find this book useful. In addition, many chapters from this book could be included in graduate-level classes in statistical bioinformatics for training future biostatisticians who will be expected to deal with genomic data in basic biomedical research, genomic clinical trials and personalized med...

INL Human Resource Development and the Next-Generation Safeguards Initiative

Energy Technology Data Exchange (ETDEWEB)

Gouveia, Fernando; Metcalf, Richard Royce Madison

2010-07-01

It is the stated goal of the Next Generation Safeguards Initiative (NGSI) to promote the development of a strengthened nuclear safeguards base, one with the potential to advance the secure and peaceful implementation of nuclear energy world-wide. To meet this goal, the initiative, among other things, has sought to develop a revitalized effort to ensure the continued availability of next generation safeguards professionals. Accordingly, this paper serves to outline the human capital building strategies taken by Idaho National Laboratory (INL) in line with the NGSI. Various components are presented in detail, including INL’s efforts directed at university outreach, in particular the laboratory’s summer internship program, along with the development of various innovative training programs and long-term oriented strategies for student professional development. Special highlights include a video training series, developed by INL in cooperation with LLNL and other laboratories, which sought to expose students and entry-level professionals to the concept and practice of international nuclear safeguards.

Next Generation Workload Management and Analysis System for Big Data

Energy Technology Data Exchange (ETDEWEB)

De, Kaushik [Univ. of Texas, Arlington, TX (United States)

2017-04-24

We report on the activities and accomplishments of a four-year project (a three-year grant followed by a one-year no cost extension) to develop a next generation workload management system for Big Data. The new system is based on the highly successful PanDA software developed for High Energy Physics (HEP) in 2005. PanDA is used by the ATLAS experiment at the Large Hadron Collider (LHC), and the AMS experiment at the space station. The program of work described here was carried out by two teams of developers working collaboratively at Brookhaven National Laboratory (BNL) and the University of Texas at Arlington (UTA). These teams worked closely with the original PanDA team – for the sake of clarity the work of the next generation team will be referred to as the BigPanDA project. Their work has led to the adoption of BigPanDA by the COMPASS experiment at CERN, and many other experiments and science projects worldwide.

Addressing Three Common Myths about the Next Generation Science Standards

Science.gov (United States)

Huff, Kenneth L.

2016-01-01

Although the "Next Generation Science Standards" (NGSS Lead States 2013) were released over two years ago, misconceptions about what they are--and are not--persist. The "NGSS" provide for consistent science education opportunities for all students--regardless of demographics--with a level of rigor expected in every location and…

Comparison of three jet events to predictions from a next-to-leading order calculation

Energy Technology Data Exchange (ETDEWEB)

Brandl, Alexander [Univ. of New Mexico, Albuquerque, NM (United States)

2002-01-01

The properties of three-jet events in data of integrated luminosity 86±4 pb^-1 from CDF Run 1b and with total transverse energy greater than 175 GeV have been analyzed and compared to predictions from a next-to-leading order perturbative QCD calculation.

Compact 2100 nm laser diode module for next-generation DIRCM

Science.gov (United States)

Dvinelis, Edgaras; Greibus, Mindaugas; TrinkÅ«nas, Augustinas; NaujokaitÄ--, Greta; Vizbaras, Augustinas; Vizbaras, Dominykas; Vizbaras, Kristijonas

2017-10-01

Compact high-power 2100 nm laser diode module for next-generation directional infrared countermeasure (DIRCM) systems is presented. Next-generation DIRCM systems require compact, light-weight and robust laser modules which could provide intense IR light emission capable of disrupting the tracking sensor of heat-seeking missile. Currently used solid-state and fiber laser solutions for mid-IR band are bulky and heavy making them difficult to implement in smaller form-factor DIRCM systems. Recent development of GaSb laser diode technology greatly improved optical output powers and efficiencies of laser diodes working in 1900 - 2450 nm band [1] while also maintaining very attractive size, weight, power consumption and cost characteristics. 2100 nm laser diode module presented in this work performance is based on high-efficiency broad emitting area GaSb laser diode technology. Each laser diode emitter is able to provide 1 W of CW output optical power with working point efficiency up to 20% at temperature of 20 °C. For output beam collimation custom designed fast-axis collimator and slow-axis collimator lenses were used. These lenses were actively aligned and attached using UV epoxy curing. Total 2 emitters stacked vertically were used in 2100 nm laser diode module. Final optical output power of the module goes up to 2 W at temperature of 20 °C. Total dimensions of the laser diode module are 35 x 25 x 16 mm (L x W x H) with a weight of 28 grams. Finally output beam is bore-sighted to mechanical axes of the module housing allowing for easy integration into next-generation DIRCM systems.

Next-generation genome-scale models for metabolic engineering

DEFF Research Database (Denmark)

King, Zachary A.; Lloyd, Colton J.; Feist, Adam M.

2015-01-01

Constraint-based reconstruction and analysis (COBRA) methods have become widely used tools for metabolic engineering in both academic and industrial laboratories. By employing a genome-scale in silico representation of the metabolic network of a host organism, COBRA methods can be used to predict...... examples of applying COBRA methods to strain optimization are presented and discussed. Then, an outlook is provided on the next generation of COBRA models and the new types of predictions they will enable for systems metabolic engineering....

Towards next-generation biodiversity assessment using DNA metabarcoding

DEFF Research Database (Denmark)

Taberlet, Pierre; Coissac, Eric; Pompanon, Francois

2012-01-01

Virtually all empirical ecological studies require species identification during data collection. DNA metabarcoding refers to the automated identification of multiple species from a single bulk sample containing entire organisms or from a single environmental sample containing degraded DNA (soil......, water, faeces, etc.). It can be implemented for both modern and ancient environmental samples. The availability of next-generation sequencing platforms and the ecologists need for high-throughput taxon identification have facilitated the emergence of DNA metabarcoding. The potential power of DNA...

JVM: Java Visual Mapping tool for next generation sequencing read.

Science.gov (United States)

Yang, Ye; Liu, Juan

2015-01-01

We developed a program JVM (Java Visual Mapping) for mapping next generation sequencing read to reference sequence. The program is implemented in Java and is designed to deal with millions of short read generated by sequence alignment using the Illumina sequencing technology. It employs seed index strategy and octal encoding operations for sequence alignments. JVM is useful for DNA-Seq, RNA-Seq when dealing with single-end resequencing. JVM is a desktop application, which supports reads capacity from 1 MB to 10 GB.

Development of technology for next generation reactor - Research of evaluation technology for nuclear power plant -

Energy Technology Data Exchange (ETDEWEB)

Park, Jong Kyun; Chang, Moon Heuy; Hwang, Yung Dong [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)] [and others

1993-09-01

For development of next generation reactor, a project for evaluation technology for nuclear power plant is performed. Evaluation technology is essential to next generation reactor for reactor safety and system analysis. For design concept, detailed evaluation technologies are studied as follows: evaluation of safety margin, evaluation of safety facilities, evaluation of measurement and control technology; man-machine interface. Especially for thermal efficiency, thermal properties and chemical composition of inconel 690 tube, instead of inconel 600 tube, are measured for steam generator. (Author).

Next Generation Carbon-Nitrogen Dynamics Model

Science.gov (United States)

Xu, C.; Fisher, R. A.; Vrugt, J. A.; Wullschleger, S. D.; McDowell, N. G.

2012-12-01

Nitrogen is a key regulator of vegetation dynamics, soil carbon release, and terrestrial carbon cycles. Thus, to assess energy impacts on the global carbon cycle and future climates, it is critical that we have a mechanism-based and data-calibrated nitrogen model that simulates nitrogen limitation upon both above and belowground carbon dynamics. In this study, we developed a next generation nitrogen-carbon dynamic model within the NCAR Community Earth System Model (CESM). This next generation nitrogen-carbon dynamic model utilized 1) a mechanistic model of nitrogen limitation on photosynthesis with nitrogen trade-offs among light absorption, electron transport, carboxylation, respiration and storage; 2) an optimal leaf nitrogen model that links soil nitrogen availability and leaf nitrogen content; and 3) an ecosystem demography (ED) model that simulates the growth and light competition of tree cohorts and is currently coupled to CLM. Our three test cases with changes in CO2 concentration, growing temperature and radiation demonstrate the model's ability to predict the impact of altered environmental conditions on nitrogen allocations. Currently, we are testing the model against different datasets including soil fertilization and Free Air CO2 enrichment (FACE) experiments across different forest types. We expect that our calibrated model will considerably improve our understanding and predictability of vegetation-climate interactions.itrogen allocation model evaluations. The figure shows the scatter plots of predicted and measured Vc,max and Jmax scaled to 25 oC (i.e.,Vc,max25 and Jmax25) at elevated CO2 (570 ppm, test case one), reduced radiation in canopy (0.1-0.9 of the radiation at the top of canopy, test case two) and reduced growing temperature (15oC, test case three). The model is first calibrated using control data under ambient CO2 (370 ppm), radiation at the top of the canopy (621 μmol photon/m2/s), the normal growing temperature (30oC). The fitted model

Nuclear Knowledge to the Next Generation

International Nuclear Information System (INIS)

Mazour, Thomas; Kossilov, Andrei

2004-01-01

The safe, reliable, and cost-effective operation of Nuclear Power Plants (NPPs) requires that personnel possess and maintain the requisite knowledge, skills, and attitudes to do their jobs properly. Such knowledge includes not only the technical competencies required by the nature of the technology and particular engineering designs, but also the softer competencies associated with effective management, communication and teamwork. Recent studies have shown that there has been a loss of corporate knowledge and memory. Both explicit knowledge and tacit knowledge must be passed on to the next generation of workers in the industry to ensure a quality workforce. New and different techniques may be required to ensure timely and effective knowledge retention and transfer. The IAEA prepared a report on this subject. The main conclusions from the report regarding strategies for managing the aging workforce are included. Also included are main conclusions from the report regarding the capture an d preservation of mission critical knowledge, and the effective transfer of this knowledge to the next generation of NPP personnel. The nuclear industry due to its need for well-documented procedures, specifications, design basis, safety analyses, etc., has a greater fraction of its mission critical knowledge as explicit knowledge than do many other industries. This facilitates the task of knowledge transfer. For older plants in particular, there may be a need for additional efforts to transfer tacit knowledge to explicit knowledge to support major strategic initiatives such as plant license extensions/renewals, periodic safety reviews, major plant upgrades, and plant specific control room simulator development. The challenge in disseminating explicit knowledge is to make employees aware that it is available and provide easy access in formats and forms that are usable. Tacit knowledge is more difficult to identify and disseminate. The challenge is to identify what can be converted to

Using Digital Watermarking for Securing Next Generation Media Broadcasts

Science.gov (United States)

Birk, Dominik; Gaines, Seán

The Internet presents a problem for the protection of intellectual property. Those who create content must be adequately compensated for the use of their works. Rights agencies who monitor the use of these works exist in many jurisdictions. In the traditional broadcast environment this monitoring is a difficult task. With Internet Protocol Television (IPTV) and Next Generation Networks (NGN) this situation is further complicated.

High Throughput Line-of-Sight MIMO Systems for Next Generation Backhaul Applications

Science.gov (United States)

Song, Xiaohang; Cvetkovski, Darko; Hälsig, Tim; Rave, Wolfgang; Fettweis, Gerhard; Grass, Eckhard; Lankl, Berthold

2017-09-01

The evolution to ultra-dense next generation networks requires a massive increase in throughput and deployment flexibility. Therefore, novel wireless backhaul solutions that can support these demands are needed. In this work we present an approach for a millimeter wave line-of-sight MIMO backhaul design, targeting transmission rates in the order of 100 Gbit/s. We provide theoretical foundations for the concept showcasing its potential, which are confirmed through channel measurements. Furthermore, we provide insights into the system design with respect to antenna array setup, baseband processing, synchronization, and channel equalization. Implementation in a 60 GHz demonstrator setup proves the feasibility of the system concept for high throughput backhauling in next generation networks.

Generation After Next Propulsor Research: Robust Design for Embedded Engine Systems

Science.gov (United States)

Arend, David J.; Tillman, Gregory; O'Brien, Walter F.

2012-01-01

The National Aeronautics and Space Administration, United Technologies Research Center and Virginia Polytechnic and State University have contracted to pursue multi-disciplinary research into boundary layer ingesting (BLI) propulsors for generation after next environmentally responsible subsonic fixed wing aircraft. This Robust Design for Embedded Engine Systems project first conducted a high-level vehicle system study based on a large commercial transport class hybrid wing body aircraft, which determined that a 3 to 5 percent reduction in fuel burn could be achieved over a 7,500 nanometer mission. Both pylon-mounted baseline and BLI propulsion systems were based on a low-pressure-ratio fan (1.35) in an ultra-high-bypass ratio engine (16), consistent with the next generation of advanced commercial turbofans. An optimized, coupled BLI inlet and fan system was subsequently designed to achieve performance targets identified in the system study. The resulting system possesses an inlet with total pressure losses less than 0.5%, and a fan stage with an efficiency debit of less than 1.5 percent relative to the pylon-mounted, clean-inflow baseline. The subject research project has identified tools and methodologies necessary for the design of next-generation, highly-airframe-integrated propulsion systems. These tools will be validated in future large-scale testing of the BLI inlet / fan system in NASA's 8 foot x 6 foot transonic wind tunnel. In addition, fan unsteady response to screen-generated total pressure distortion is being characterized experimentally in a JT15D engine test rig. These data will document engine sensitivities to distortion magnitude and spatial distribution, providing early insight into key physical processes that will control BLI propulsor design.

BATCH-GE: Batch analysis of Next-Generation Sequencing data for genome editing assessment

Science.gov (United States)

Boel, Annekatrien; Steyaert, Woutert; De Rocker, Nina; Menten, Björn; Callewaert, Bert; De Paepe, Anne; Coucke, Paul; Willaert, Andy

2016-01-01

Targeted mutagenesis by the CRISPR/Cas9 system is currently revolutionizing genetics. The ease of this technique has enabled genome engineering in-vitro and in a range of model organisms and has pushed experimental dimensions to unprecedented proportions. Due to its tremendous progress in terms of speed, read length, throughput and cost, Next-Generation Sequencing (NGS) has been increasingly used for the analysis of CRISPR/Cas9 genome editing experiments. However, the current tools for genome editing assessment lack flexibility and fall short in the analysis of large amounts of NGS data. Therefore, we designed BATCH-GE, an easy-to-use bioinformatics tool for batch analysis of NGS-generated genome editing data, available from https://github.com/WouterSteyaert/BATCH-GE.git. BATCH-GE detects and reports indel mutations and other precise genome editing events and calculates the corresponding mutagenesis efficiencies for a large number of samples in parallel. Furthermore, this new tool provides flexibility by allowing the user to adapt a number of input variables. The performance of BATCH-GE was evaluated in two genome editing experiments, aiming to generate knock-out and knock-in zebrafish mutants. This tool will not only contribute to the evaluation of CRISPR/Cas9-based experiments, but will be of use in any genome editing experiment and has the ability to analyze data from every organism with a sequenced genome. PMID:27461955

Looking ahead to our next generation of nurse leaders: Generation X Nurse Managers.

Science.gov (United States)

Keys, Yolanda

2014-01-01

The present inquiry identifies elements of professional success, and personal and professional fulfilment as defined by Generation X Nurse Managers. Although work concerning Nurse Manager preparation has been documented, there is a paucity of research specific to the generation of nurses next in line to assume leadership roles. For the purposes of this study, a qualitative approach was used to develop insight regarding Generation X Nurse Managers and their perspectives on professional success, personal and professional fulfilment, and organisational environments that are conducive to loyalty and long-term professional commitment. Findings from this study reinforced those identified in the original study in that inflexible organisational cultures, a lack of opportunities for upward mobility, the need to be available at all times, feeling stereotyped or undervalued can all be barriers to members of Generation X perceptions of professional success and professional and personal fulfilment. Study findings suggest that Generation X Nurse Managers would benefit from initiatives focused on better preparation for the Nurse Manager role, openness to innovative scheduling alternatives and tailored support and feedback. © 2014 John Wiley & Sons Ltd.

e+e- event generator EPOCS user's manual

International Nuclear Information System (INIS)

Kato, Kiyoshi; Munehisa, Tomo.

1987-07-01

EPOCS(Electron POsitron Collision Simulator) is a Monte-Carlo event generator for high energy e + e - annihilation. This program generates events based on the standard model, i.e., quantum chromodynamics (QCD) and electro-weak theory. It works at the center-of-mass energy below W + W - production, i.e., in the energy region of TRISTAN, SLC and LEP. For these high energy machines one of the important subjects is the exploration for the top quark. The production and hadronization of the top quark is included in EPOCS. Besides the top quark, we expect 'new' physics in this high energy region. EPOCS has enough flexibility for users to cope with a new idea. Users can register a new particle, modify the built-in particle data, define new primary interactions and so on. The event generator has a number of parameters, both physical parameters and control parameters. Users can control most of these parameters in EPOCS at will. (author)

Fetal Kidney Anomalies: Next Generation Sequencing

DEFF Research Database (Denmark)

Rasmussen, Maria; Sunde, Lone; Nielsen, Marlene Louise

Aim and Introduction Identification of abnormal kidneys in the fetus may lead to termination of the pregnancy and raises questions about the underlying cause and recurrence risk in future pregnancies. In this study, we investigate the effectiveness of targeted next generation sequencing in fetuses...... with prenatally detected kidney anomalies in order to uncover genetic explanations and assess recurrence risk. Also, we aim to study the relation between genetic findings and post mortem kidney histology. Methods The study comprises fetuses diagnosed prenatally with bilateral kidney anomalies that have undergone...... postmortem examination. The approximately 110 genes included in the targeted panel were chosen on the basis of their potential involvement in embryonic kidney development, cystic kidney disease, or the renin-angiotensin system. DNA was extracted from fetal tissue samples or cultured chorion villus cells...

Next Generation Nuclear Plant System Requirements Manual

International Nuclear Information System (INIS)

Not Listed

2008-01-01

System Requirements Manual for the NGNP Project. The Energy Policy Act of 2005 (H.R. 6; EPAct), which was signed into law by President George W. Bush in August 2005, required the Secretary of the U.S. Department of Energy (DOE) to establish a project to be known as the Next Generation Nuclear Plant (NGNP) Project. According to the EPAct, the NGNP Project shall consist of the research, development, design, construction, and operation of a prototype plant (to be referred to herein as the NGNP) that (1) includes a nuclear reactor based on the research and development (R and D) activities supported by the Generation IV Nuclear Energy Systems initiative, and (2) shall be used to generate electricity, to produce hydrogen, or to both generate electricity and produce hydrogen. The NGNP Project supports both the national need to develop safe, clean, economical nuclear energy and the Nuclear Hydrogen Initiative (NHI), which has the goal of establishing greenhouse-gas-free technologies for the production of hydrogen. The DOE has selected the helium-cooled High Temperature Gas-Cooled Reactor (HTGR) as the reactor concept to be used for the NGNP because it is the only near-term Generation IV concept that has the capability to provide process heat at high-enough temperatures for highly efficient production of hydrogen. The EPAct also names the Idaho National Laboratory (INL), the DOE's lead national laboratory for nuclear energy research, as the site for the prototype NGNP

NextGEOSS: The Next Generation Data Hub For Earth Observations

Science.gov (United States)

Lilja Bye, Bente; De Lathouwer, Bart; Catarino, Nuno; Concalves, Pedro; Trijssenaar, Nicky; Grosso, Nuno; Meyer-Arnek, Julian; Goor, Erwin

2017-04-01

The Group on Earth observation embarked on the next 10 year phase with an ambition to streamline and further develop its achievements in building the Global Earth Observing System of Systems (GEOSS). The NextGEOSS project evolves the European vision of GEOSS data exploitation for innovation and business, relying on the three main pillars of engaging communities, delivering technological developments and advocating the use of GEOSS, in order to support the creation and deployment of Earth observation based innovative research activities and commercial services. In this presentation we will present the NextGEOSS concept, a concept that revolves around providing the data and resources to the users communities, together with Cloud resources, seamlessly connected to provide an integrated ecosystem for supporting applications. A central component of NextGEOSS is the strong emphasis put on engaging the communities of providers and users, and bridging the space in between.

Super- and Transcritical Fluid Expansions for Next-Generation Energy Conversion Systems

NARCIS (Netherlands)

Harinck, J.

2010-01-01

The next generation of thermodynamic power cycles offers great potential as the conceptual basis for sustainable energy converters. Examples are the supercritical and superheated Organic Rankine cycle, the transcritical condensation cycle, the supercritical Brayton cycle, the Organic Stirling cycle

Energy Efficient Glass Melting - The Next Generation Melter

Energy Technology Data Exchange (ETDEWEB)

David Rue

2008-03-01

The objective of this project is to demonstrate a high intensity glass melter, based on the submerged combustion melting technology. This melter will serve as the melting and homogenization section of a segmented, lower-capital cost, energy-efficient Next Generation Glass Melting System (NGMS). After this project, the melter will be ready to move toward commercial trials for some glasses needing little refining (fiberglass, etc.). For other glasses, a second project Phase or glass industry research is anticipated to develop the fining stage of the NGMS process.

Investigating the Impact of the Cisco 21st Century Schools Initiative on Harrison County School District. Summative Report

Science.gov (United States)

Ba, Harouna; Meade, Terri; Pierson, Elizabeth; Ferguson, Camille; Roy, Amanda; Williams, Hakim

2009-01-01

There are 21 schools in the Harrison County School District (HCSD), located in southern Mississippi, in the Gulfport/Biloxi metropolitan area. Of those, only Harrison Central 9th Grade (HC9) and Harrison County High School (HCHS) participated in the Cisco 21S Initiative--therefore, this summary will focus on only administrators, teachers,…

Investigating the Impact of the Cisco 21st Century Schools Initiative on Forrest County School District. Summative Report

Science.gov (United States)

Ba, Harouna; Meade, Terri; Pierson, Elizabeth; Ferguson, Camille; Roy, Amanda; Williams, Hakim

2009-01-01

Located in southern Mississippi, the Forrest County School District (FCSD) consists of six schools: three K-6 elementary schools, two K-8 elementary-middle schools, and one high school (grades 9-12), all of which have been involved in the Cisco Initiative since its inception. The district employed 16 administrators, 7 technology staff members, and…

MiSeq: A Next Generation Sequencing Platform for Genomic Analysis.

Science.gov (United States)

Ravi, Rupesh Kanchi; Walton, Kendra; Khosroheidari, Mahdieh

2018-01-01

MiSeq, Illumina's integrated next generation sequencing instrument, uses reversible-terminator sequencing-by-synthesis technology to provide end-to-end sequencing solutions. The MiSeq instrument is one of the smallest benchtop sequencers that can perform onboard cluster generation, amplification, genomic DNA sequencing, and data analysis, including base calling, alignment and variant calling, in a single run. It performs both single- and paired-end runs with adjustable read lengths from 1 × 36 base pairs to 2 × 300 base pairs. A single run can produce output data of up to 15 Gb in as little as 4 h of runtime and can output up to 25 M single reads and 50 M paired-end reads. Thus, MiSeq provides an ideal platform for rapid turnaround time. MiSeq is also a cost-effective tool for various analyses focused on targeted gene sequencing (amplicon sequencing and target enrichment), metagenomics, and gene expression studies. For these reasons, MiSeq has become one of the most widely used next generation sequencing platforms. Here, we provide a protocol to prepare libraries for sequencing using the MiSeq instrument and basic guidelines for analysis of output data from the MiSeq sequencing run.

Answers to Teachers' Questions about the Next Generation Science Standards

Science.gov (United States)

Workosky, Cindy; Willard, Ted

2015-01-01

K-12 teachers of science have been digging into the "Next Generation Science Standards" ("NGSS") (NGSS Lead States 2013) to begin creating plans and processes for translating them for classroom instruction. As teachers learn about the NGSS, they have asked about the general structure of the standards document and how to read…

The Next Generation of Science Standards: Implications for Biology Education

Science.gov (United States)

Bybee, Rodger W.

2012-01-01

The release of A Framework for K-12 Science Education: Practices, Crosscutting Concepts, and Core Ideas (NRC, 2012) provides the basis for the next generation of science standards. This article first describes that foundation for the life sciences; it then presents a draft standard for natural selection and evolution. Finally, there is a…

Oak Ridge National Laboratory Next Generation Safeguards Initiative

Energy Technology Data Exchange (ETDEWEB)

Kirk, Bernadette Lugue [ORNL; Eipeldauer, Mary D [ORNL; Whitaker, J Michael [ORNL

2011-12-01

In 2007, the Department of Energy's National Nuclear Security Administration (DOE/NNSA) Office of Nonproliferation and International Security (NA-24) completed a comprehensive review of the current and potential future challenges facing the international safeguards system. The review examined trends and events impacting the mission of international safeguards and the implications of expanding and evolving mission requirements on the legal authorities and institutions that serve as the foundation of the international safeguards system, as well as the technological, financial, and human resources required for effective safeguards implementation. The review's findings and recommendations were summarized in the report, 'International Safeguards: Challenges and Opportunities for the 21st Century (October 2007)'. One of the report's key recommendations was for DOE/NNSA to launch a major new program to revitalize the international safeguards technology and human resource base. In 2007, at the International Atomic Energy Agency's General Conference, then Secretary of Energy Samuel W. Bodman announced the newly created Next Generation Safeguards Initiative (NGSI). NGSI consists of five program elements: (1) Policy development and outreach; (2) Concepts and approaches; (3) Technology and analytical methodologies; (4) Human resource development; and (5) Infrastructure development. The ensuing report addresses the 'Human Resource Development (HRD)' component of NGSI. The goal of the HRD as defined in the NNSA Program Plan (November 2008) is 'to revitalize and expand the international safeguards human capital base by attracting and training a new generation of talent.' One of the major objectives listed in the HRD goal includes education and training, outreach to universities, professional societies, postdoctoral appointments, and summer internships at national laboratories. ORNL is a participant in the NGSI program, together

Status of advanced containment systems for next generation water reactors

International Nuclear Information System (INIS)

1994-06-01

The present IAEA status report is intended to provide information on the current status and development of containment systems of the next generation reactors for electricity production and, particularly, to highlight features which may be considered advanced, i.e. which present improved performance with evolutionary or innovative design solutions or new design approaches. The objectives of the present status report are: To present, on a concise and consistent basis, selected containment designs currently being developed in the world; to review and compare new approaches to the design bases for the containments, in order to identify common trends, that may eventually lead to greater worldwide consensus, to identify, list and compare existing design objectives for advanced containments, related to safety, availability, maintainability, plant life, decommissioning, economics, etc.; to describe the general approaches adopted in different advanced containments to cope with various identified challenges, both those included in the current design bases and those related to new events considered in the design; to briefly identify recent achievements and future needs for new or improved computer codes, standards, experimental research, prototype testing, etc. related to containment systems; to describe the outstanding features of some containments or specific solutions proposed by different parties and which are generally interesting to the international scientific community. 36 refs, 27 figs, 1 tab

Process Improvement for Next Generation Space Flight Vehicles: MSFC Lessons Learned

Science.gov (United States)

Housch, Helen

2008-01-01

This viewgraph presentation reviews the lessons learned from process improvement for Next Generation Space Flight Vehicles. The contents include: 1) Organizational profile; 2) Process Improvement History; 3) Appraisal Preparation; 4) The Appraisal Experience; 5) Useful Tools; and 6) Is CMMI working?

Application of next generation sequencing in clinical microbiology and infection prevention

NARCIS (Netherlands)

Deurenberg, Ruud H.; Bathoorn, Erik; Chlebowicz, Monika A.; Couto, Natacha; Ferdous, Mithila; Garcia-Cobos, Silvia; Kooistra-Smid, Anna M. D.; Raangs, Erwin C.; Rosema, Sigrid; Veloo, Alida C. M.; Zhou, Kai; Friedrich, Alexander W.; Rossen, John W. A.

2017-01-01

Current molecular diagnostics of human pathogens provide limited information that is often not sufficient for outbreak and transmission investigation. Next generation sequencing (NGS) determines the DNA sequence of a complete bacterial genome in a single sequence run, and from these data,

Towards the next generation of simplified Dark Matter models

Science.gov (United States)

Albert, Andreas; Bauer, Martin; Brooke, Jim; Buchmueller, Oliver; Cerdeño, David G.; Citron, Matthew; Davies, Gavin; de Cosa, Annapaola; De Roeck, Albert; De Simone, Andrea; Du Pree, Tristan; Flaecher, Henning; Fairbairn, Malcolm; Ellis, John; Grohsjean, Alexander; Hahn, Kristian; Haisch, Ulrich; Harris, Philip C.; Khoze, Valentin V.; Landsberg, Greg; McCabe, Christopher; Penning, Bjoern; Sanz, Veronica; Schwanenberger, Christian; Scott, Pat; Wardle, Nicholas

2017-06-01

This White Paper is an input to the ongoing discussion about the extension and refinement of simplified Dark Matter (DM) models. It is not intended as a comprehensive review of the discussed subjects, but instead summarises ideas and concepts arising from a brainstorming workshop that can be useful when defining the next generation of simplified DM models (SDMM). In this spirit, based on two concrete examples, we show how existing SDMM can be extended to provide a more accurate and comprehensive framework to interpret and characterise collider searches. In the first example we extend the canonical SDMM with a scalar mediator to include mixing with the Higgs boson. We show that this approach not only provides a better description of the underlying kinematic properties that a complete model would possess, but also offers the option of using this more realistic class of scalar mixing models to compare and combine consistently searches based on different experimental signatures. The second example outlines how a new physics signal observed in a visible channel can be connected to DM by extending a simplified model including effective couplings. In the next part of the White Paper we outline other interesting options for SDMM that could be studied in more detail in the future. Finally, we review important aspects of supersymmetric models for DM and use them to propose how to develop more complete SDMMs. This White Paper is a summary of the brainstorming meeting "Next generation of simplified Dark Matter models" that took place at Imperial College, London on May 6, 2016, and corresponding follow-up studies on selected subjects.

DARC: Next generation decentralized control framework for robot applications

DEFF Research Database (Denmark)

Kjærgaard, Morten; Andersen, Nils Axel; Ravn, Ole

2013-01-01

This paper presents DARC, a next generation control framework for robot applications. It is designed to be equally powerful in prototyping research projects and for building serious commercial robots running on low powered embedded hardware, thus closing the gab between research and industry....... It incorporates several new techniques such as a decentralized peer-to-peer architecture, transparent network distribution of the control system, and automatic run-time supervision to guarantee robustness....

Development and Application of a Next Generation Air Sensor Network for the Hong Kong Marathon 2015 Air Quality Monitoring.

Science.gov (United States)

Sun, Li; Wong, Ka Chun; Wei, Peng; Ye, Sheng; Huang, Hao; Yang, Fenhuan; Westerdahl, Dane; Louie, Peter K K; Luk, Connie W Y; Ning, Zhi

2016-02-05

This study presents the development and evaluation of a next generation air monitoring system with both laboratory and field tests. A multi-parameter algorithm was used to correct for the impact of environmental conditions on the electrochemical sensors for carbon monoxide (CO) and nitrogen dioxide (NO2) pollutants. The field evaluation in an urban roadside environment in comparison to designated monitors showed good agreement with measurement error within 5% of the pollutant concentrations. Multiple sets of the developed system were then deployed in the Hong Kong Marathon 2015 forming a sensor-based network along the marathon route. Real-time air pollution concentration data were wirelessly transmitted and the Air Quality Health Index (AQHI) for the Green Marathon was calculated, which were broadcast to the public on an hourly basis. The route-specific sensor network showed somewhat different pollutant patterns than routine air monitoring, indicating the immediate impact of traffic control during the marathon on the roadside air quality. The study is one of the first applications of a next generation sensor network in international sport events, and it demonstrated the usefulness of the emerging sensor-based air monitoring technology in rapid network deployment to supplement existing air monitoring.

Statistical framework for detection of genetically modified organisms based on Next Generation Sequencing.

Science.gov (United States)

Willems, Sander; Fraiture, Marie-Alice; Deforce, Dieter; De Keersmaecker, Sigrid C J; De Loose, Marc; Ruttink, Tom; Herman, Philippe; Van Nieuwerburgh, Filip; Roosens, Nancy

2016-02-01

Because the number and diversity of genetically modified (GM) crops has significantly increased, their analysis based on real-time PCR (qPCR) methods is becoming increasingly complex and laborious. While several pioneers already investigated Next Generation Sequencing (NGS) as an alternative to qPCR, its practical use has not been assessed for routine analysis. In this study a statistical framework was developed to predict the number of NGS reads needed to detect transgene sequences, to prove their integration into the host genome and to identify the specific transgene event in a sample with known composition. This framework was validated by applying it to experimental data from food matrices composed of pure GM rice, processed GM rice (noodles) or a 10% GM/non-GM rice mixture, revealing some influential factors. Finally, feasibility of NGS for routine analysis of GM crops was investigated by applying the framework to samples commonly encountered in routine analysis of GM crops. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Bringing Next-Generation Sequencing into the Classroom through a Comparison of Molecular Biology Techniques

Science.gov (United States)

Bowling, Bethany; Zimmer, Erin; Pyatt, Robert E.

2014-01-01

Although the development of next-generation (NextGen) sequencing technologies has revolutionized genomic research and medicine, the incorporation of these topics into the classroom is challenging, given an implied high degree of technical complexity. We developed an easy-to-implement, interactive classroom activity investigating the similarities…

Monte Carlo next-event point flux estimation for RCP01

International Nuclear Information System (INIS)

Martz, R.L.; Gast, R.C.; Tyburski, L.J.

1991-01-01

Two next event point estimators have been developed and programmed into the RCP01 Monte Carlo program for solving neutron transport problems in three-dimensional geometry with detailed energy description. These estimators use a simplified but accurate flux-at-a-point tallying technique. Anisotropic scattering in the lab system at the collision site is accounted for by determining the exit energy that corresponds to the angle between the location of the collision and the point detector. Elastic, inelastic, and thermal kernel scattering events are included in this formulation. An averaging technique is used in both estimators to eliminate the well-known problem of infinite variance due to collisions close to the point detector. In a novel approach to improve the estimator's efficiency, a Russian roulette scheme based on anticipated flux fall off is employed where averaging is not appropriate. A second estimator successfully uses a simple rejection technique in conjunction with detailed tracking where averaging isn't needed. Test results show good agreement with known numeric solutions. Efficiencies are examined as a function of input parameter selection and problem difficulty

Engineered CRISPR Systems for Next Generation Gene Therapies.

Science.gov (United States)

Pineda, Michael; Moghadam, Farzaneh; Ebrahimkhani, Mo R; Kiani, Samira

2017-09-15

An ideal in vivo gene therapy platform provides safe, reprogrammable, and precise strategies which modulate cell and tissue gene regulatory networks with a high temporal and spatial resolution. Clustered regularly interspaced short palindromic repeats (CRISPR), a bacterial adoptive immune system, and its CRISPR-associated protein 9 (Cas9), have gained attention for the ability to target and modify DNA sequences on demand with unprecedented flexibility and precision. The precision and programmability of Cas9 is derived from its complexation with a guide-RNA (gRNA) that is complementary to a desired genomic sequence. CRISPR systems open-up widespread applications including genetic disease modeling, functional screens, and synthetic gene regulation. The plausibility of in vivo genetic engineering using CRISPR has garnered significant traction as a next generation in vivo therapeutic. However, there are hurdles that need to be addressed before CRISPR-based strategies are fully implemented. Some key issues center on the controllability of the CRISPR platform, including minimizing genomic-off target effects and maximizing in vivo gene editing efficiency, in vivo cellular delivery, and spatial-temporal regulation. The modifiable components of CRISPR systems: Cas9 protein, gRNA, delivery platform, and the form of CRISPR system delivered (DNA, RNA, or ribonucleoprotein) have recently been engineered independently to design a better genome engineering toolbox. This review focuses on evaluating CRISPR potential as a next generation in vivo gene therapy platform and discusses bioengineering advancements that can address challenges associated with clinical translation of this emerging technology.

Direct target NOTES: prospective applications for next generation robotic platforms.

Science.gov (United States)

Atallah, S; Hodges, A; Larach, S W

2018-05-01

A new era in surgical robotics has centered on alternative access to anatomic targets and next generation designs include flexible, single-port systems which follow circuitous rather than straight pathways. Such systems maintain a small footprint and could be utilized for specialized operations based on direct organ target natural orifice transluminal endoscopic surgery (NOTES), of which transanal total mesorectal excision (taTME) is an important derivative. During two sessions, four direct target NOTES operations were conducted on a cadaveric model using a flexible robotic system to demonstrate proof-of-concept of the application of a next generation robotic system to specific types of NOTES operations, all of which required removal of a direct target organ through natural orifice access. These four operations were (a) robotic taTME, (b) robotic transvaginal hysterectomy in conjunction with (c) robotic transvaginal salpingo-oophorectomy, and in an ex vivo model, (d) trans-cecal appendectomy. Feasibility was demonstrated in all cases using the Flex ® Robotic System with Colorectal Drive. During taTME, the platform excursion was 17 cm along a non-linear path; operative time was 57 min for the transanal portion of the dissection. Robotic transvaginal hysterectomy was successfully completed in 78 min with transvaginal extraction of the uterus, although laparoscopic assistance was required. Robotic transvaginal unilateral salpingo-oophorectomy with transvaginal extraction of the ovary and fallopian tube was performed without laparoscopic assistance in 13.5 min. In an ex vivo model, a robotic trans-cecal appendectomy was also successfully performed for the purpose of demonstrating proof-of-concept only; this was completed in 24 min. A flexible robotic system has the potential to access anatomy along circuitous paths, making it a suitable platform for direct target NOTES. The conceptual operations posed could be considered suitable for next generation robotics once

The Next Generation Science Standards: A Focus on Physical Science

Science.gov (United States)

Krajcik, Joe

2013-01-01

This article describes ways to adapt U.S. science curriculum to the U.S. National Research Council (NRC) "Framework for K-12 Science Education" and "Next Generation of Science Standards" (NGSS), noting their focus on teaching the physical sciences. The overall goal of the Framework and NGSS is to help all learners develop the…

Research and Development Supporting a Next Generation Germanium Double Beta Decay Experiment

Science.gov (United States)

Rielage, Keith; Elliott, Steve; Chu, Pinghan; Goett, Johnny; Massarczyk, Ralph; Xu, Wenqin

2015-10-01

To improve the search for neutrinoless double beta decay, the next-generation experiments will increase in source mass and continue to reduce backgrounds in the region of interest. A promising technology for the next generation experiment is large arrays of Germanium p-type point contact detectors enriched in 76-Ge. The experience, expertise and lessons learned from the MAJORANA DEMONSTRATOR and GERDA experiments naturally lead to a number of research and development activities that will be useful in guiding a future experiment utilizing Germanium. We will discuss some R&D activities including a hybrid cryostat design, background reduction in cabling, connectors and electronics, and modifications to reduce assembly time. We acknowledge the support of the U.S. Department of Energy through the LANL/LDRD Program.

[Detection of the mitochondrial DNA haplotype characteristic of the least cisco (Coregonus sardinella, Valenciennes, 1848) in the vendace (C. albula, Linnaeus, 1758) population of Vodlozero (the Baltic Sea basin)].

Science.gov (United States)

Borovikova, E A; Makhrov, A A

2009-01-01

Analysis of the nucleotide sequence of the mitochondrial ND-1 gene in the vendace population in lake Vodlozero (the eastern part of the Baltic Sea basin) revealed a sequence variant that is closely related to that of the least cisco of Siberia (the Indigirka River). Thus, together with the results of morphological and allozyme analysis of this population performed earlier, the results obtained in this study are suggestive of the immigration of the least cisco to the Baltic Sea basin during the last glaciation.

Beamstrahlung spectra in next generation linear colliders. Revision

Energy Technology Data Exchange (ETDEWEB)

Barklow, T.; Chen, P. [Stanford Linear Accelerator Center, Menlo Park, CA (United States); Kozanecki, W. [DAPNIA-SPP, CEN-Saclay (France)

1992-04-01

For the next generation of linear colliders, the energy loss due to beamstrahlung during the collision of the e{sup +}e{sup {minus}} beams is expected to substantially influence the effective center-of-mass energy distribution of the colliding particles. In this paper, we first derive analytical formulae for the electron and photon energy spectra under multiple beamstrahlung processes, and for the e{sup +}e{sup {minus}} and {gamma}{gamma} differential luminosities. We then apply our formulation to various classes of 500 GeV e{sup +}e{sup {minus}} linear collider designs currently under study.

Semantic e-Learning: Next Generation of e-Learning?

Science.gov (United States)

Konstantinos, Markellos; Penelope, Markellou; Giannis, Koutsonikos; Aglaia, Liopa-Tsakalidi

Semantic e-learning aspires to be the next generation of e-learning, since the understanding of learning materials and knowledge semantics allows their advanced representation, manipulation, sharing, exchange and reuse and ultimately promote efficient online experiences for users. In this context, the paper firstly explores some fundamental Semantic Web technologies and then discusses current and potential applications of these technologies in e-learning domain, namely, Semantic portals, Semantic search, personalization, recommendation systems, social software and Web 2.0 tools. Finally, it highlights future research directions and open issues of the field.

A Survey on 5G: The Next Generation of Mobile Communication

OpenAIRE

Panwar, Nisha; Sharma, Shantanu; Singh, Awadhesh Kumar

2015-01-01

The rapidly increasing number of mobile devices, voluminous data, and higher data rate are pushing to rethink the current generation of the cellular mobile communication. The next or fifth generation (5G) cellular networks are expected to meet high-end requirements. The 5G networks are broadly characterized by three unique features: ubiquitous connectivity, extremely low latency, and very high-speed data transfer. The 5G networks would provide novel architectures and technologies beyond state...

Software R&D for Next Generation of HEP Experiments, Inspired by Theano

CERN Multimedia

CERN. Geneva

2015-01-01

In the next decade, the frontiers of High Energy Physics (HEP) will be explored by three machines: the High Luminosity Large Hadron Collider (HL-LHC) in Europe, the Long Base Neutrino Facility (LBNF) in the US, and the International Linear Collider (ILC) in Japan. These next generation experiments must address two fundamental problems in the current generation of HEP experimental software: the inability to take advantage and adapt to the rapidly evolving processor landscape, and the difficulty in developing and maintaining increasingly complex software systems by physicists. I will propose a strategy, inspired by the automatic optimization and code generation in Theano, to simultaneously address both problems. I will describe three R&D projects with short-term physics deliverables aimed at developing this strategy. The first project is to develop maximally sensitive General Search for New Physics at the LHC by applying the Matrix Element Method running GPUs of HPCs. The second is to classify and reconstru...

Structural variation discovery in the cancer genome using next generation sequencing: Computational solutions and perspectives

Science.gov (United States)

Liu, Biao; Conroy, Jeffrey M.; Morrison, Carl D.; Odunsi, Adekunle O.; Qin, Maochun; Wei, Lei; Trump, Donald L.; Johnson, Candace S.; Liu, Song; Wang, Jianmin

2015-01-01

Somatic Structural Variations (SVs) are a complex collection of chromosomal mutations that could directly contribute to carcinogenesis. Next Generation Sequencing (NGS) technology has emerged as the primary means of interrogating the SVs of the cancer genome in recent investigations. Sophisticated computational methods are required to accurately identify the SV events and delineate their breakpoints from the massive amounts of reads generated by a NGS experiment. In this review, we provide an overview of current analytic tools used for SV detection in NGS-based cancer studies. We summarize the features of common SV groups and the primary types of NGS signatures that can be used in SV detection methods. We discuss the principles and key similarities and differences of existing computational programs and comment on unresolved issues related to this research field. The aim of this article is to provide a practical guide of relevant concepts, computational methods, software tools and important factors for analyzing and interpreting NGS data for the detection of SVs in the cancer genome. PMID:25849937

SMITH: a LIMS for handling next-generation sequencing workflows

OpenAIRE

Venco, Francesco; Vaskin, Yuriy; Ceol, Arnaud; Muller, Heiko

2014-01-01

Background Life-science laboratories make increasing use of Next Generation Sequencing (NGS) for studying bio-macromolecules and their interactions. Array-based methods for measuring gene expression or protein-DNA interactions are being replaced by RNA-Seq and ChIP-Seq. Sequencing is generally performed by specialized facilities that have to keep track of sequencing requests, trace samples, ensure quality and make data available according to predefined privileges. An integrated tool helps to ...

Benchmark problem suite for reactor physics study of LWR next generation fuels

International Nuclear Information System (INIS)

Yamamoto, Akio; Ikehara, Tadashi; Ito, Takuya; Saji, Etsuro

2002-01-01

This paper proposes a benchmark problem suite for studying the physics of next-generation fuels of light water reactors. The target discharge burnup of the next-generation fuel was set to 70 GWd/t considering the increasing trend in discharge burnup of light water reactor fuels. The UO 2 and MOX fuels are included in the benchmark specifications. The benchmark problem consists of three different geometries: fuel pin cell, PWR fuel assembly and BWR fuel assembly. In the pin cell problem, detailed nuclear characteristics such as burnup dependence of nuclide-wise reactivity were included in the required calculation results to facilitate the study of reactor physics. In the assembly benchmark problems, important parameters for in-core fuel management such as local peaking factors and reactivity coefficients were included in the required results. The benchmark problems provide comprehensive test problems for next-generation light water reactor fuels with extended high burnup. Furthermore, since the pin cell, the PWR assembly and the BWR assembly problems are independent, analyses of the entire benchmark suite is not necessary: e.g., the set of pin cell and PWR fuel assembly problems will be suitable for those in charge of PWR in-core fuel management, and the set of pin cell and BWR fuel assembly problems for those in charge of BWR in-core fuel management. (author)

Full C-band Tunable MEMS-VCSEL for Next Generation G.metro Mobile Front- and Backhauling

DEFF Research Database (Denmark)

Wagner, Christoph; Zou, Shihuan Jim; Ortsiefer, Markus

2017-01-01

We report full C-band tunable, 10 Gbit/s capability, directly modulated MEMS-VCSEL for next generation converged mobile fronthaul and backhaul applications. Bit error rates below 10(-9) were achieved over up to 40 km SSMF.......We report full C-band tunable, 10 Gbit/s capability, directly modulated MEMS-VCSEL for next generation converged mobile fronthaul and backhaul applications. Bit error rates below 10(-9) were achieved over up to 40 km SSMF....

The "Next Generation Science Standards" and the Earth and Space Sciences

Science.gov (United States)

Wysession, Michael E.

2013-01-01

The "Next Generation Science Standards" ("NGSS"), due to be released this spring, represents a revolutionary step toward establishing modern, national K-12 science education standards. Based on the recommendations of the National Research Council's "A Framework for K-12 Science Education: Practices, Crosscutting…

A framework for QoS & mobility in the Internet next generation

NARCIS (Netherlands)

Rexhepi, Vlora; Karagiannis, Georgios; Heijenk, Geert; Pras, Aiko

2000-01-01

It is expected that the Internet next generation architecture will support applications with different quality of service requirements, independently of whether their location is fixed or mobile. However, enabling QoS in Internet is a tough challenge, and it gets even tougher when the mobile

A framework for QoS & mobility in the Internet next generation

NARCIS (Netherlands)

Karagiannis, Georgios; Rexhepi, Vlora; Heijenk, Geert

It is expected that the next generation Internet architecture will support applications with different quality of service requirements, independently of whether their location is fixed or movable. However, enabling QoS in Internet is a tough challenge, and it gets even tougher when the mobile

Multi-Stage Admission Control for Load Balancing in Next Generation Systems

DEFF Research Database (Denmark)

Mihovska, Albena D.; Anggorojati, Bayu; Luo, Jijun

2008-01-01

This paper describes a load-dependent multi-stage admission control suitable for next generation systems. The concept uses decision polling in entities located at different levels of the architecture hierarchy and based on the load to activate a sequence of actions related to the admission...

Implementation of defence in depth for next generation light water reactors

International Nuclear Information System (INIS)

1997-12-01

The publication of this IAEA technical document represents the conclusion of a task, initiated in 1995, devoted to defence in depth in future reactors. It focuses mainly on the next generation of LWRs, although many general considerations may also apply to other types of reactors

Next Generation Science Partnerships

Science.gov (United States)

Magnusson, J.

2016-02-01

I will provide an overview of the Next Generation Science Standards (NGSS) and demonstrate how scientists and educators can use these standards to strengthen and enhance their collaborations. The NGSS are rich in content and practice and provide all students with an internationally-benchmarked science education. Using these state-led standards to guide outreach efforts can help develop and sustain effective and mutually beneficial teacher-researcher partnerships. Aligning outreach with the three dimensions of the standards can help make research relevant for target audiences by intentionally addressing the science practices, cross-cutting concepts, and disciplinary core ideas of the K-12 science curriculum that drives instruction and assessment. Collaborations between researchers and educators that are based on this science framework are more sustainable because they address the needs of both scientists and educators. Educators are better able to utilize science content that aligns with their curriculum. Scientists who learn about the NGSS can better understand the frameworks under which educators work, which can lead to more extensive and focused outreach with teachers as partners. Based on this model, the International Ocean Discovery Program (IODP) develops its education materials in conjunction with scientists and educators to produce accurate, standards-aligned activities and curriculum-based interactions with researchers. I will highlight examples of IODP's current, successful teacher-researcher collaborations that are intentionally aligned with the NGSS.

Next Generation Nuclear Plant Project Technology Development Roadmaps: The Technical Path Forward

Energy Technology Data Exchange (ETDEWEB)

John Collins

2009-01-01

This document presents the Next Generation Nuclear Plant (NGNP) Systems, Subsystems, and Components, establishes a baseline for the current technology readiness status, and provides a path forward to achieve increasing levels of technical maturity.

The "Next Generation Science Standards" and the Earth and Space Sciences

Science.gov (United States)

Wysession, Michael E.

2013-01-01

In this article, Michael E. Wysession comments on the "Next Generation Science Standards" (NGSS), which are based on the recommendations of the National Research Council and represent a revolutionary step toward establishing modern, national K-12 science education standards. The NGSS involves significant changes from traditional…

Informing the next nuclear generation - how does the Ginna plant branch do it?

International Nuclear Information System (INIS)

Saavedra, A.

1995-01-01

Most of us are familiar with the latest advertising phrase, ''Our children are our future.'' This phrase has been used in so many instances - from concerns about waste, Social Security, and the federal deficit to drug abuse and violence. One more area can be added to the list and advertised nuclear power. Since the establishment of the Ginna plant branch (GPB) in 1992, our target audience has been the next nuclear generation (our children), but our vehicle for dissemination has been the current generation (the adults). Have you ever thought about how often your opinions affect the children you come in contact with? One of GPB's goals is to provide as much information as possible to teachers, neighbors, and civic organizations of our community so that there is a nuclear future that can be carried on by the next generation

Towards identifying the next generation of superfund and hazardous waste site contaminants

Science.gov (United States)

Ela, Wendell P.; Sedlak, David L.; Barlaz, Morton A.; Henry, Heather F.; Muir, Derek C.G.; Swackhamer, Deborah L.; Weber, Eric J.; Arnold, Robert G.; Ferguson, P. Lee; Field, Jennifer A.; Furlong, Edward T.; Giesy, John P.; Halden, Rolf U.; Henry, Tala; Hites, Ronald A.; Hornbuckle, Keri C.; Howard, Philip H.; Luthy, Richard G.; Meyer, Anita K.; Saez, A. Eduardo; vom Saal, Frederick S.; Vulpe, Chris D.; Wiesner, Mark R.

2011-01-01

Background This commentary evolved from a workshop sponsored by the National Institute of Environmental Health Sciences titled "Superfund Contaminants: The Next Generation" held in Tucson, Arizona, in August 2009. All the authors were workshop participants.

Fiscal Year 2014 Annual Report on BNLs Next Generation Safeguards Initiative Human Capital Development Activities

Energy Technology Data Exchange (ETDEWEB)

Pepper, Susan E. [Brookhaven National Lab. (BNL), Upton, NY (United States)

2014-10-10

Brookhaven National Laboratory’s (BNL’s) Nonproliferation and National Security Department contributes to the National Nuclear Security Administration Office of Nonproliferation and International Security Next Generation Safeguards Initiative (NGSI) through university engagement, safeguards internships, safeguards courses, professional development, recruitment, and other activities aimed at ensuring the next generation of international safeguards professionals is adequately prepared to support the U.S. safeguards mission. This report is a summary of BNL s work under the NGSI program in Fiscal Year 2014.

Investigating the Impact of the Cisco 21st Century Schools Initiative on Forrest County Agricultural High School. Summative Report

Science.gov (United States)

Ba, Harouna; Meade, Terri; Pierson, Elizabeth; Ferguson, Camille; Roy, Amanda; Williams, Hakim

2009-01-01

Forrest County Agricultural High School (FCAHS) is located in Brooklyn, a small rural town in southern Mississippi and part of the Hattiesburg Metropolitan Statistical Area. Unlike the other schools that participated in the Cisco 21S initiative, FCAHS is not part of a larger school district. Therefore, the unit of analysis throughout this summary…

On the ergodic capacity of legacy systems in the presence of next generation interference

KAUST Repository

Mahmood, Nurul Huda

2011-11-01

Next generation wireless systems facilitating better utilization of the scarce radio spectrum have emerged as a response to inefficient rigid spectrum assignment policies. These are comprised of intelligent radio nodes that opportunistically operate in the radio spectrum of existing legacy systems; yet unwanted interference at the legacy receivers is unavoidable. In order to design efficient next generation systems and to minimize their harmful consequences, it is necessary to realize their impact on the performance of legacy systems. In this work, a generalized framework for the ergodic capacity analysis of such legacy systems in the presence of interference from next generation systems is presented. The analysis is built around a model developed for the statistical representation of the interference at the legacy receivers, which is then used to evaluate the ergodic capacity of the legacy system. Moreover, this analysis is not limited to the context of legacy systems, and is in fact applicaple to any interference limited system. Findings of analytical performance analyses are confirmed through selected computer-based Monte-Carlo simulations. © 2011 IEEE.

Next Generation Campus Network Deployment Project Based on Softswitch

OpenAIRE

HU Feng; LIU Ziyan

2011-01-01

After analyzing the current networks of Guizhou University，we brought forward a scheme of next generation campus networks based on softswitch technology by choosing SoftX3000 switching system of HuaWei and provided the specific solution of accessing campus networks in this paper. It is proved that this scheme is feasible by using OPNET, which not only accomplished the integration of the PSTN and IP networks but also achieved the combining of voice services and data services.

Applying Next Generation Sequencing to Skeletal Development and Disease

OpenAIRE

Bowen, Margot Elizabeth

2013-01-01

Next Generation Sequencing (NGS) technologies have dramatically increased the throughput and lowered the cost of DNA sequencing. In this thesis, I apply these technologies to unresolved questions in skeletal development and disease. Firstly, I use targeted re-sequencing of genomic DNA to identify the genetic cause of the cartilage tumor syndrome, metachondromatosis (MC). I show that the majority of MC patients carry heterozygous loss-of-function mutations in the PTPN11 gene, which encodes a p...

Next Generation Qualification: Nanometrics T120PH Seismometer Evaluation

Energy Technology Data Exchange (ETDEWEB)

Merchant, Bion J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Slad, George William [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2017-10-01

Sandia National Laboratories has tested and evaluated three seismometers, the Trillium 120PH, manufactured by Nanometrics. These seismometers measure broadband ground velocity using a UVW configuration with feedback control in a mechanically levelled borehole package. The purpose of the seismometer evaluation was to determine a measured sensitivity, response, self- noise, dynamic range, and self-calibration ability. The Nanometrics Trillium 120PH seismometers are being evaluated for the U.S. Air Force as part of their Next Generation Qualification effort.

Power Electronics for the Next Generation Wind Turbine System

DEFF Research Database (Denmark)

Ma, Ke

generation unit, are becoming crucial in the wind turbine system. The objective of this project is to study the power electronics technology used for the next generation wind turbines. Some emerging challenges as well as potentials like the cost of energy and reliability are going to be addressed. First...... conversion is pushed to multi-MW level with high power density requirement. It has also been revealed that thermal stress in the power semiconductors is closely related to many determining factors in the wind power application like the reliability, cost, power density, etc. therefore it is an important......The wind power generation has been steadily growing both for the total installed capacity and for the individual turbine size. Due to much more significant impacts to the power grid, the power electronics, which can change the behavior of wind turbines from an unregulated power source to an active...

Detection of TET2, KRAS and CBL variants by Next Generation ...

African Journals Online (AJOL)

Dilara Fatma Akin

2015-10-01

Oct 1, 2015 ... sarcoma viral oncogene homolog (KRAS), and Casitas B-cell ... AML by screening hot-spot exons of TET2, KRAS, and CBL using Next Generation Sequencing ... Methods: Eight patients who were diagnosed with pediatric AML at Losante ..... mutations in pre-leukemic stem cells in acute myeloid leukemia.

Teaching the "Geo" in Geography with the Next Generation Science Standards

Science.gov (United States)

Wysession, Michael E.

2016-01-01

The Next Generation Science Standards (NGSS; Achieve 2014, 532; Figure 1A) represent a new approach to K-12 science education that involves the interweaving of three educational dimensions: Science and Engineering Practices (SEPs), Disciplinary Core Ideas (DCIs), and Crosscutting Concepts (CCCs). Unlike most preexisting state science standards for…

Next Generation Science Standards: Considerations for Curricula, Assessments, Preparation, and Implementation

Science.gov (United States)

Best, Jane; Dunlap, Allison

2014-01-01

This policy brief provides an overview of the Next Generation Science Standards (NGSS), discusses policy considerations for adopting or adapting the new standards, and presents examples from states considering or implementing the NGSS. Changing academic standards is a complex process that requires significant investments of time, money, and human…

Am I my Family's Keeper? : Disclosure Dilemmas in Next Generation Sequencing

NARCIS (Netherlands)

Wouters, Roel H P; Bijlsma, Rhodé M; Ausems, Margreet G E M; van Delden, Johannes J M; Voest, Emile E; Bredenoord, Annelien L

2016-01-01

Ever since genetic testing is possible for specific mutations, ethical debate has sparked on the question of whether professionals have a duty to warn not only patients but also their relatives that might be at risk for hereditary diseases. As next generation sequencing swiftly finds its way into

Diamond Light Source - A Next Generation SR Facility

International Nuclear Information System (INIS)

Materlik, G.

2004-01-01

After the very successful start and the by now almost 10 years operation of the 3rd generation x-ray sources ESRF, APS and Spring-8 smaller storage rings are being planned and constructed with properties emphasising applications with photon energies around the 10 keV spectral region. In the UK the Government and the medical foundation Wellcome Trust have decided to build the Diamond Light Source Facility in the South of Oxfordshire right next to the Rutherford Appleton Laboratory. The joint venture company Diamond Light Source Limited has been created to plan, construct, and operate this facility. (author)

Next generation framework for aquatic modeling of the Earth System

Science.gov (United States)

Fekete, B. M.; Wollheim, W. M.; Wisser, D.; Vörösmarty, C. J.

2009-03-01

Earth System model development is becoming an increasingly complex task. As scientists attempt to represent the physical and bio-geochemical processes and various feedback mechanisms in unprecedented detail, the models themselves are becoming increasingly complex. At the same time, the complexity of the surrounding IT infrastructure is growing as well. Earth System models must manage a vast amount of data in heterogeneous computing environments. Numerous development efforts are on the way to ease that burden and offer model development platforms that reduce IT challenges and allow scientists to focus on their science. While these new modeling frameworks (e.g. FMS, ESMF, CCA, OpenMI) do provide solutions to many IT challenges (performing input/output, managing space and time, establishing model coupling, etc.), they are still considerably complex and often have steep learning curves. The Next generation Framework for Aquatic Modeling of the Earth System (NextFrAMES, a revised version of FrAMES) have numerous similarities to those developed by other teams, but represents a novel model development paradigm. NextFrAMES is built around a modeling XML that lets modelers to express the overall model structure and provides an API for dynamically linked plugins to represent the processes. The model XML is executed by the NextFrAMES run-time engine that parses the model definition, loads the module plugins, performs the model I/O and executes the model calculations. NextFrAMES has a minimalistic view representing spatial domains and treats every domain (regardless of its layout such as grid, network tree, individual points, polygons, etc.) as vector of objects. NextFrAMES performs computations on multiple domains and interactions between different spatial domains are carried out through couplers. NextFrAMES allows processes to operate at different frequencies by providing rudimentary aggregation and disaggregation facilities. NextFrAMES was designed primarily for

Molecular Diagnostics in Pathology: Time for a Next-Generation Pathologist?

Science.gov (United States)

Fassan, Matteo

2018-03-01

- Comprehensive molecular investigations of mainstream carcinogenic processes have led to the use of effective molecular targeted agents in most cases of solid tumors in clinical settings. - To update readers regarding the evolving role of the pathologist in the therapeutic decision-making process and the introduction of next-generation technologies into pathology practice. - Current literature on the topic, primarily sourced from the PubMed (National Center for Biotechnology Information, Bethesda, Maryland) database, were reviewed. - Adequate evaluation of cytologic-based and tissue-based predictive diagnostic biomarkers largely depends on both proper pathologic characterization and customized processing of biospecimens. Moreover, increased requests for molecular testing have paralleled the recent, sharp decrease in tumor material to be analyzed-material that currently comprises cytology specimens or, at minimum, small biopsies in most cases of metastatic/advanced disease. Traditional diagnostic pathology has been completely revolutionized by the introduction of next-generation technologies, which provide multigene, targeted mutational profiling, even in the most complex of clinical cases. Combining traditional and molecular knowledge, pathologists integrate the morphological, clinical, and molecular dimensions of a disease, leading to a proper diagnosis and, therefore, the most-appropriate tailored therapy.

Data-Driven Handover Optimization in Next Generation Mobile Communication Networks

Directory of Open Access Journals (Sweden)

Po-Chiang Lin

2016-01-01

Full Text Available Network densification is regarded as one of the important ingredients to increase capacity for next generation mobile communication networks. However, it also leads to mobility problems since users are more likely to hand over to another cell in dense or even ultradense mobile communication networks. Therefore, supporting seamless and robust connectivity through such networks becomes a very important issue. In this paper, we investigate handover (HO optimization in next generation mobile communication networks. We propose a data-driven handover optimization (DHO approach, which aims to mitigate mobility problems including too-late HO, too-early HO, HO to wrong cell, ping-pong HO, and unnecessary HO. The key performance indicator (KPI is defined as the weighted average of the ratios of these mobility problems. The DHO approach collects data from the mobile communication measurement results and provides a model to estimate the relationship between the KPI and features from the collected dataset. Based on the model, the handover parameters, including the handover margin and time-to-trigger, are optimized to minimize the KPI. Simulation results show that the proposed DHO approach could effectively mitigate mobility problems.

High-performance ferroelectric and magnetoresistive materials for next-generation thermal detector arrays

Science.gov (United States)

Todd, Michael A.; Donohue, Paul P.; Watton, Rex; Williams, Dennis J.; Anthony, Carl J.; Blamire, Mark G.

2002-12-01

This paper discusses the potential thermal imaging performance achievable from thermal detector arrays and concludes that the current generation of thin-film ferroelectric and resistance bolometer based detector arrays are limited by the detector materials used. It is proposed that the next generation of large uncooled focal plane arrays will need to look towards higher performance detector materials - particularly if they aim to approach the fundamental performance limits and compete with cooled photon detector arrays. Two examples of bolometer thin-film materials are described that achieve high performance from operating around phase transitions. The material Lead Scandium Tantalate (PST) has a paraelectric-to-ferroelectric phase transition around room temperature and is used with an applied field in the dielectric bolometer mode for thermal imaging. PST films grown by sputtering and liquid-source CVD have shown merit figures for thermal imaging a factor of 2 to 3 times higher than PZT-based pyroelectric thin films. The material Lanthanum Calcium Manganite (LCMO) has a paramagnetic to ferromagnetic phase transition around -20oC. This paper describes recent measurements of TCR and 1/f noise in pulsed laser-deposited LCMO films on Neodymium Gallate substrates. These results show that LCMO not only has high TCR's - up to 30%/K - but also low 1/f excess noise, with bolometer merit figures at least an order of magnitude higher than Vanadium Oxide, making it ideal for the next generation of microbolometer arrays. These high performance properties come at the expense of processing complexities and novel device designs will need to be introduced to realize the potential of these materials in the next generation of thermal detectors.

Estabilishing requirements for the next generation of pressurized water reactors--reducing the uncertainty

International Nuclear Information System (INIS)

Chernock, W.P.; Corcoran, W.R.; Rasin, W.H.; Stahlkopf, K.E.

1987-01-01

The Electric Power Research Institute is managing a major effort to establish requirements for the next generation of U.S. light water reactors. This effort is the vital first step in preserving the viability of the nuclear option to contribute to meet U.S. national electric power capacity needs in the next century. Combustion Engineering, Inc. and Duke Power Company formed a team to participate in the EPRI program which is guided by a Utility Steering committee consisting of experienced utility technical executives. A major thrust of the program is to reduce the uncertainties which would be faced by the utility executives in choosing the nuclear option. The uncertainties to be reduced include those related to safety, economic, operational, and regulatory aspects of advanced light water reactors. This paper overviews the Requirements Document program as it relates to the U.S. Advanced Light Water Reactor (ALWR) effort in reducing these uncertainties and reports the status of efforts to establish requirements for the next generation of pressurized water reactors. It concentrates on progress made in reducing the uncertainties which would deter selection of the nuclear option for contributing to U.S. national electric power capacity needs in the next century and updates previous reports in the same area. (author)

NGSUtils: a software suite for analyzing and manipulating next-generation sequencing datasets

OpenAIRE

Breese, Marcus R.; Liu, Yunlong

2013-01-01

Summary: NGSUtils is a suite of software tools for manipulating data common to next-generation sequencing experiments, such as FASTQ, BED and BAM format files. These tools provide a stable and modular platform for data management and analysis.

Design Features and Technology Uncertainties for the Next Generation Nuclear Plant

Energy Technology Data Exchange (ETDEWEB)

John M. Ryskamp; Phil Hildebrandt; Osamu Baba; Ron Ballinger; Robert Brodsky; Hans-Wolfgang Chi; Dennis Crutchfield; Herb Estrada; Jeane-Claude Garnier; Gerald Gordon; Richard Hobbins; Dan Keuter; Marilyn Kray; Philippe Martin; Steve Melancon; Christian Simon; Henry Stone; Robert Varrin; Werner von Lensa

2004-06-01

This report presents the conclusions, observations, and recommendations of the Independent Technology Review Group (ITRG) regarding design features and important technology uncertainties associated with very-high-temperature nuclear system concepts for the Next Generation Nuclear Plant (NGNP). The ITRG performed its reviews during the period November 2003 through April 2004.

Next-Generation Bio-Products Sowing the Seeds of Success for Sustainable Agriculture

Directory of Open Access Journals (Sweden)

Henry Müller

2013-10-01

Full Text Available Plants have recently been recognized as meta-organisms due to a close symbiotic relationship with their microbiome. Comparable to humans and other eukaryotic hosts, plants also harbor a “second genome” that fulfills important host functions. These advances were driven by both “omics”-technologies guided by next-generation sequencing and microscopic insights. Additionally, these new results influence applied fields such as biocontrol and stress protection in agriculture, and new tools may impact (i the detection of new bio-resources for biocontrol and plant growth promotion, (ii the optimization of fermentation and formulation processes for biologicals, (iii stabilization of the biocontrol effect under field conditions, and (iv risk assessment studies for biotechnological applications. Examples are presented and discussed for the fields mentioned above, and next-generation bio-products were found as a sustainable alternative for agriculture.

Nucleic acid reactivity : challenges for next-generation semiempirical quantum models

OpenAIRE

Huang, Ming; Giese, Timothy J.; York, Darrin M.

2015-01-01

Semiempirical quantum models are routinely used to study mechanisms of RNA catalysis and phosphoryl transfer reactions using combined quantum mechanical/molecular mechanical methods. Herein, we provide a broad assessment of the performance of existing semiempirical quantum models to describe nucleic acid structure and reactivity in order to quantify their limitations and guide the development of next-generation quantum models with improved accuracy. Neglect of diatomic diffierential overlap (...

NREL Next Generation Drivetrain: Mechanical Design and Test Plan (Poster)

Energy Technology Data Exchange (ETDEWEB)

Keller, J.; Halse, C.

2014-05-01

The Department of Energy and industry partners are sponsoring a $3m project for design and testing of a 'Next Generation' wind turbine drivetrain at the National Renewable Energy Laboratory (NREL). This poster focuses on innovative aspects of the gearbox design, completed as part of an end-to-end systems engineering approach incorporating innovations that increase drivetrain reliability, efficiency, torque density and minimize capital cost.

NNSA Program Develops the Next Generation of Nuclear Security Experts

Energy Technology Data Exchange (ETDEWEB)

Brim, Cornelia P.; Disney, Maren V.

2015-09-02

NNSA is fostering the next generation of nuclear security experts is through its successful NNSA Graduate Fellowship Program (NGFP). NGFP offers its Fellows an exceptional career development opportunity through hands-on experience supporting NNSA mission areas across policy and technology disciplines. The one-year assignments give tomorrow’s leaders in global nuclear security and nonproliferation unparalleled exposure through assignments to Program Offices across NNSA.

Next Generation Qualification: Kinemetrics STS-5A Seismometer Evaluation

Energy Technology Data Exchange (ETDEWEB)

Merchant, Bion John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Slad, George William [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2017-10-01

Sandia National Laboratories has tested and evaluated two seismometers, the STS-5A, manufactured by Kinemetrics. These seismometers measure three axes of broadband ground velocity using a UVW configuration with feedback control in a mechanically levelled borehole package. The purpose of the seismometer evaluation was to determine a measured sensitivity, response, self-noise, dynamic range, and self-calibration ability. The Kinemetrics STS-5A seismometers are being evaluated for the U.S. Air Force as part of their Next Generation Qualification effort.

Estimation of allele frequency and association mapping using next-generation sequencing data

DEFF Research Database (Denmark)

Kim, Su Yeon; Lohmueller, Kirk E; Albrechtsen, Anders

2011-01-01

Estimation of allele frequency is of fundamental importance in population genetic analyses and in association mapping. In most studies using next-generation sequencing, a cost effective approach is to use medium or low-coverage data (e.g., frequency estimation...

Development and Application of a Next Generation Air Sensor Network for the Hong Kong Marathon 2015 Air Quality Monitoring

Directory of Open Access Journals (Sweden)

Li Sun

2016-02-01

Full Text Available This study presents the development and evaluation of a next generation air monitoring system with both laboratory and field tests. A multi-parameter algorithm was used to correct for the impact of environmental conditions on the electrochemical sensors for carbon monoxide (CO and nitrogen dioxide (NO2 pollutants. The field evaluation in an urban roadside environment in comparison to designated monitors showed good agreement with measurement error within 5% of the pollutant concentrations. Multiple sets of the developed system were then deployed in the Hong Kong Marathon 2015 forming a sensor-based network along the marathon route. Real-time air pollution concentration data were wirelessly transmitted and the Air Quality Health Index (AQHI for the Green Marathon was calculated, which were broadcast to the public on an hourly basis. The route-specific sensor network showed somewhat different pollutant patterns than routine air monitoring, indicating the immediate impact of traffic control during the marathon on the roadside air quality. The study is one of the first applications of a next generation sensor network in international sport events, and it demonstrated the usefulness of the emerging sensor-based air monitoring technology in rapid network deployment to supplement existing air monitoring.

Development and Application of a Next Generation Air Sensor Network for the Hong Kong Marathon 2015 Air Quality Monitoring

Science.gov (United States)

Sun, Li; Wong, Ka Chun; Wei, Peng; Ye, Sheng; Huang, Hao; Yang, Fenhuan; Westerdahl, Dane; Louie, Peter K.K.; Luk, Connie W.Y.; Ning, Zhi

2016-01-01

This study presents the development and evaluation of a next generation air monitoring system with both laboratory and field tests. A multi-parameter algorithm was used to correct for the impact of environmental conditions on the electrochemical sensors for carbon monoxide (CO) and nitrogen dioxide (NO2) pollutants. The field evaluation in an urban roadside environment in comparison to designated monitors showed good agreement with measurement error within 5% of the pollutant concentrations. Multiple sets of the developed system were then deployed in the Hong Kong Marathon 2015 forming a sensor-based network along the marathon route. Real-time air pollution concentration data were wirelessly transmitted and the Air Quality Health Index (AQHI) for the Green Marathon was calculated, which were broadcast to the public on an hourly basis. The route-specific sensor network showed somewhat different pollutant patterns than routine air monitoring, indicating the immediate impact of traffic control during the marathon on the roadside air quality. The study is one of the first applications of a next generation sensor network in international sport events, and it demonstrated the usefulness of the emerging sensor-based air monitoring technology in rapid network deployment to supplement existing air monitoring. PMID:26861336

Next Generation Agricultural System Data, Models and Knowledge Products: Introduction

Science.gov (United States)

Antle, John M.; Jones, James W.; Rosenzweig, Cynthia E.

2016-01-01

Agricultural system models have become important tools to provide predictive and assessment capability to a growing array of decision-makers in the private and public sectors. Despite ongoing research and model improvements, many of the agricultural models today are direct descendants of research investments initially made 30-40 years ago, and many of the major advances in data, information and communication technology (ICT) of the past decade have not been fully exploited. The purpose of this Special Issue of Agricultural Systems is to lay the foundation for the next generation of agricultural systems data, models and knowledge products. The Special Issue is based on a 'NextGen' study led by the Agricultural Model Intercomparison and Improvement Project (AgMIP) with support from the Bill and Melinda Gates Foundation.

Next-Generation Mitogenomics: A Comparison of Approaches Applied to Caecilian Amphibian Phylogeny

OpenAIRE

Maddock, Simon T.; Briscoe, Andrew G.; Wilkinson, Mark; Waeschenbach, Andrea; San Mauro, Diego; Day, Julia J.; Littlewood, D. Tim J.; Foster, Peter G.; Nussbaum, Ronald A.; Gower, David J.

2016-01-01

Mitochondrial genome (mitogenome) sequences are being generated with increasing speed due to the advances of next-generation sequencing (NGS) technology and associated analytical tools. However, detailed comparisons to explore the utility of alternative NGS approaches applied to the same taxa have not been undertaken. We compared a ‘traditional’ Sanger sequencing method with two NGS approaches (shotgun sequencing and non-indexed, multiplex amplicon sequencing) on four different sequencing pla...

Evaluation Metrics for Intermediate Heat Exchangers for Next Generation Nuclear Reactors

International Nuclear Information System (INIS)

Sabharwall, Piyush; Kim, Eung Soo; Anderson, Nolan

2011-01-01

The Department of Energy (DOE) is working with industry to develop a next generation, high-temperature gas-cooled reactor (HTGR) as a part of the effort to supply the United States with abundant, clean, and secure energy as initiated by the Energy Policy Act of 2005 (EPAct; Public Law 109-58,2005). The NGNP Project, led by the Idaho National Laboratory (INL), will demonstrate the ability of the HTGR to generate hydrogen, electricity, and/or high-quality process heat for a wide range of industrial applications.

Astro Data Science: The Next Generation

Science.gov (United States)

Mentzel, Chris

2018-01-01

Astronomers have been at the forefront of data-driven discovery since before the days of Kepler. Using data in the scientific inquiry into the workings of the the universe is the lifeblood of the field. This said, data science is considered a new thing, and researchers from every discipline are rushing to learn data science techniques, train themselves on data science tools, and even leaving academia to become data scientists. It is undeniable that our ability to harness new computational and statistical methods to make sense of today’s unprecedented size, complexity, and fast streaming data is helping scientists make new discoveries. The question now is how to ensure that researchers can employ these tools and use them appropriately. This talk will cover the state of data science as it relates to scientific research and the role astronomers play in its development, use, and training the next generation of astro-data scientists.

Mutation Detection in Patients with Retinal Dystrophies Using Targeted Next Generation Sequencing

DEFF Research Database (Denmark)

Weisschuh, Nicole; Mayer, Anja K; Strom, Tim M

2016-01-01

Retinal dystrophies (RD) constitute a group of blinding diseases that are characterized by clinical variability and pronounced genetic heterogeneity. The different nonsyndromic and syndromic forms of RD can be attributed to mutations in more than 200 genes. Consequently, next generation sequencing...

A bibliometric analysis of the development of next generation active nanotechnologies

International Nuclear Information System (INIS)

Suominen, Arho; Li, Yin; Youtie, Jan; Shapira, Philip

2016-01-01

Delineating the emergence of nanotechnologies that offer new functionalities is an important element in an anticipatory approach to the governance of nanotechnology and its potential impacts. This paper examines the transition to next generation active nanotechnologies which incorporate functions that respond to the environment or systems concepts that combine devices and structures that are dynamic and which may change their states in use. We develop an approach to identifying these active nanotechnologies and then use bibliometric analysis to examine the extent of research papers and patents involving these concepts. We also examine references to environmental, health, and safety concepts in these papers, given that these next generation nanotechnologies are likely to have risk profiles that are different from those of first-generation passive nanomaterials. Our results show a steady growth overall in focus on active nanotechnologies in the research literature and in patents over the study period of 1990–2010. We also find an increase in consideration given to environmental, health, and safety topics. While gaps are highlighted in our understanding of research and innovation in active nanotechnologies, the results suggest that there is beginning to be a shift to active nanotechnologies, with the implication that governance processes need to be conscious of this shift and to prepare for it.

A bibliometric analysis of the development of next generation active nanotechnologies

Energy Technology Data Exchange (ETDEWEB)

Suominen, Arho [VTT Technical Research Centre of Finland (Finland); Li, Yin; Youtie, Jan, E-mail: jan.youtie@innovate.gatech.edu; Shapira, Philip [Georgia Institute of Technology (United States)

2016-09-15

Delineating the emergence of nanotechnologies that offer new functionalities is an important element in an anticipatory approach to the governance of nanotechnology and its potential impacts. This paper examines the transition to next generation active nanotechnologies which incorporate functions that respond to the environment or systems concepts that combine devices and structures that are dynamic and which may change their states in use. We develop an approach to identifying these active nanotechnologies and then use bibliometric analysis to examine the extent of research papers and patents involving these concepts. We also examine references to environmental, health, and safety concepts in these papers, given that these next generation nanotechnologies are likely to have risk profiles that are different from those of first-generation passive nanomaterials. Our results show a steady growth overall in focus on active nanotechnologies in the research literature and in patents over the study period of 1990–2010. We also find an increase in consideration given to environmental, health, and safety topics. While gaps are highlighted in our understanding of research and innovation in active nanotechnologies, the results suggest that there is beginning to be a shift to active nanotechnologies, with the implication that governance processes need to be conscious of this shift and to prepare for it.

Automotive Radar and Lidar Systems for Next Generation Driver Assistance Functions

Directory of Open Access Journals (Sweden)

R. H. Rasshofer

2005-01-01

Full Text Available Automotive radar and lidar sensors represent key components for next generation driver assistance functions (Jones, 2001. Today, their use is limited to comfort applications in premium segment vehicles although an evolution process towards more safety-oriented functions is taking place. Radar sensors available on the market today suffer from low angular resolution and poor target detection in medium ranges (30 to 60m over azimuth angles larger than ±30°. In contrast, Lidar sensors show large sensitivity towards environmental influences (e.g. snow, fog, dirt. Both sensor technologies today have a rather high cost level, forbidding their wide-spread usage on mass markets. A common approach to overcome individual sensor drawbacks is the employment of data fusion techniques (Bar-Shalom, 2001. Raw data fusion requires a common, standardized data interface to easily integrate a variety of asynchronous sensor data into a fusion network. Moreover, next generation sensors should be able to dynamically adopt to new situations and should have the ability to work in cooperative sensor environments. As vehicular function development today is being shifted more and more towards virtual prototyping, mathematical sensor models should be available. These models should take into account the sensor's functional principle as well as all typical measurement errors generated by the sensor.

Detection of TET2 , KRAS and CBL variants by Next Generation ...

African Journals Online (AJOL)

Aim: In this study, we aimed to find possible genetic markers for molecular analysis in childhood AML by screening hot-spot exons of TET2, KRAS, and CBL using Next Generation Sequencing (NGS) analysis. In addition, association between found variants and mutations of Januse Kinase-2 (JAK2) and Fms Related ...

Addressing Next Generation Science Standards: A Method for Supporting Classroom Teachers

Science.gov (United States)

Pellien, Tamara; Rothenburger, Lisa

2014-01-01

The Next Generation Science Standards (NGSS) will define science education for the foreseeable future, yet many educators struggle to see the bridge between current practice and future practices. The inquiry-based methods used by Extension professionals (Kress, 2006) can serve as a guide for classroom educators. Described herein is a method of…

The next generation of Palapa satellite (Palapa-C)

Science.gov (United States)

Setiawan, Bambang

The Indonesian Palapa Communication Satellite System was established in Aug. 1976 when the first satellite of Palapa A series (Palapa A1) began operation. The system is owned and operated by PT. Telekomunikasi Indonesia (Telkom), which is a state owned company. The purpose of the system was to unify the telecommunications of the nation. Many years of operation have shown that satellite technology is the best solution for improving telecommunications in Indonesia. The system was started with 2 (two) satellites, each with 12 transponders (for a total of 24), and 40 earth stations. Now the system has 3 (three) satellites, each with 24 transponders (for a total of 72 transponders), and thousands of earth stations. The services have been extended to satisfy the requirements of the region as well as the original objectives. The use of satellite transponders in the region is increasing rapidly. In the next ten years, opportunities in the satellite communications business will become even more attractive. The next generation Palapa-C will incorporate improvements in capacity, quality, and coverage. The new frequency bands (ku- and Extended-C Band) will be used to meet the new transponder capacity requirements.

Heavy ion event generator HYDJET++ (HYDrodynamics plus JETs)

Science.gov (United States)

Lokhtin, I. P.; Malinina, L. V.; Petrushanko, S. V.; Snigirev, A. M.; Arsene, I.; Tywoniuk, K.

2009-05-01

HYDJET++ is a Monte Carlo event generator for simulation of relativistic heavy ion AA collisions considered as a superposition of the soft, hydro-type state and the hard state resulting from multi-parton fragmentation. This model is the development and continuation of HYDJET event generator (Lokhtin and Snigirev, EPJC 45 (2006) 211). The main program is written in the object-oriented C++ language under the ROOT environment. The hard part of HYDJET++ is identical to the hard part of Fortran-written HYDJET and it is included in the generator structure as a separate directory. The soft part of HYDJET++ event is the "thermal" hadronic state generated on the chemical and thermal freeze-out hypersurfaces obtained from the parameterization of relativistic hydrodynamics with preset freeze-out conditions. It includes the longitudinal, radial and elliptic flow effects and the decays of hadronic resonances. The corresponding fast Monte Carlo simulation procedure, C++ code FAST MC (Amelin et al., PRC 74 (2006) 064901; PRC 77 (2008) 014903) is adapted to HYDJET++. It is designed for studying the multi-particle production in a wide energy range of heavy ion experimental facilities: from FAIR and NICA to RHIC and LHC. Program summaryProgram title: HYDJET++, version 2 Catalogue identifier: AECR_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AECR_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 100 387 No. of bytes in distributed program, including test data, etc.: 797 019 Distribution format: tar.gz Programming language: C++ (however there is a Fortran-written part which is included in the generator structure as a separate directory) Computer: Hardware independent (both C++ and Fortran compilers and ROOT environment [1] ( http://root.cern.ch/) should be installed

Next-generation approaches to the microbial ecology of food fermentations

Directory of Open Access Journals (Sweden)

Nicholas A. Bokulich1,2,3 & David A. Mills1,2,3*

2012-07-01

Full Text Available Food fermentations have enhanced human health since the dawnof time and remain a prevalent means of food processing andpreservation. Due to their cultural and nutritional importance,many of these foods have been studied in detail using moleculartools, leading to enhancements in quality and safety. Furthermore,recent advances in high-throughput sequencing technologyare revolutionizing the study of food microbial ecology,deepening insight into complex fermentation systems. Thisreview provides insight into novel applications of selectmolecular techniques, particularly next-generation sequencingtechnology, for analysis of microbial communities in fermentedfoods. We present a guideline for integrated molecular analysis offood microbial ecology and a starting point for implementingnext-generation analysis of food systems.

Methodology on the sparger development for Korean next generation reactor

International Nuclear Information System (INIS)

Kim, Hwan Yeol; Hwang, Y.D.; Kang, H.S.; Cho, B.H.; Park, J.K.

1999-06-01

In case of an accident, the safety depressurization system of Korean Next Generation Reactor (KNGR) efficiently depressurize the reactor pressure by directly discharge steam of high pressure and temperature from the pressurizer into the in-containment refuelling water storage tank (IRWST) through spargers. This report was generated for the purpose of developing the sparger of KNGR. This report presents the methodology on application of ABB-Atom. Many thermal hydraulic parameters affecting the maximum bubble could pressure were obtained and the maximum bubble cloud pressure transient curve so called forcing function of KNGR was suggested and design inputs for IRWST (bubble cloud radius vs. time, bubble cloud velocity vs. time, bubble cloud acceleration vs. time, etc.) were generated by the analytic using Rayleigh-Plesset equation. (author). 17 refs., 6 tabs., 27 figs

Methodology on the sparger development for Korean next generation reactor

Energy Technology Data Exchange (ETDEWEB)

Kim, Hwan Yeol; Hwang, Y.D.; Kang, H.S.; Cho, B.H.; Park, J.K

1999-06-01

In case of an accident, the safety depressurization system of Korean Next Generation Reactor (KNGR) efficiently depressurize the reactor pressure by directly discharge steam of high pressure and temperature from the pressurizer into the in-containment refuelling water storage tank (IRWST) through spargers. This report was generated for the purpose of developing the sparger of KNGR. This report presents the methodology on application of ABB-Atom. Many thermal hydraulic parameters affecting the maximum bubble could pressure were obtained and the maximum bubble cloud pressure transient curve so called forcing function of KNGR was suggested and design inputs for IRWST (bubble cloud radius vs. time, bubble cloud velocity vs. time, bubble cloudacceleration vs. time, etc.) were generated by the analytic using Rayleigh-Plesset equation. (author). 17 refs., 6 tabs., 27 figs.

Interferometric detectors of gravitational waves on Earth: the next generations

Energy Technology Data Exchange (ETDEWEB)

Losurdo, G [INFN Firenze - Via G.Sansone 1, 50019 - Sesto F., Firenze (Italy)], E-mail: losurdo@fi.infn.it

2008-05-15

First generation long-baseline interferometric detectors of gravitational waves are now taking data. A first detection might be possible with these instruments, but more sensitive detectors will be needed to start the field of gravitational wave astronomy. Second generation interferometers will improve the sensitivity by a factor ten, allowing to explore a universe volume 1000 times larger. The technology is almost ready and the construction will start at the beginning of the next decade. The community of the physicists involved in the field has also started to make plans for third generation detectors, for which a long term technology development program will be required. The plans for the upgrades of the existing detectors and the scenario for the evolution of the field will be reviewed in this paper.

The Next-Generation U.S. Retail Electricity Market with Customers and Prosumers—A Bibliographical Survey

Directory of Open Access Journals (Sweden)

Tao Chen

2017-12-01

Full Text Available Due to the rapidly-changing technologies in the power industry, many new references addressing the frameworks and business models of the next-generation retail electricity market are entering the research community. In particular, considering new customers with considerable demand response awareness and so-called prosumers with localized power generation based on distributed energy resources (DERs, the next-generation retail electricity market infrastructure will be a level playing field for local energy transactions, strategic pricing scheme design, new business model design and building an innovative energy ecosystem. Consequently, there is an urgent need to keep track of international experiences and activities taking place in the field of the market mechanism design problem at the distribution level. This paper provides a comprehensive survey of recent technology developments and aims to inspire awareness of the further deregulation of the electricity market, especially in areas close to customers. We mainly bring attention to the more than 90 articles published during the past five years. The collected literature has been divided into different sections to discuss different aspects of the next-generation retail electricity market under the deregulated power industry.

Reducing Risk for the Next Generation Nuclear Plant

Energy Technology Data Exchange (ETDEWEB)

John M. Beck II; Harold J. Heydt; Emmanuel O. Opare; Kyle B. Oswald

2010-07-01

The Next Generation Nuclear Plant (NGNP) Project, managed by the Idaho National Laboratory (INL), is directed by the Energy Policy Act of 2005, to research, develop, design, construct, and operate a prototype forth generation nuclear reactor to meet the needs of the 21st Century. As with all large projects developing and deploying new technologies, the NGNP has numerous risks that need to be identified, tracked, mitigated, and reduced in order for successful project completion. A Risk Management Plan (RMP) was created to outline the process the INL is using to manage the risks and reduction strategies for the NGNP Project. Integral to the RMP is the development and use of a Risk Management System (RMS). The RMS is a tool that supports management and monitoring of the project risks. The RMS does not only contain a risk register, but other functionality that allows decision makers, engineering staff, and technology researchers to review and monitor the risks as the project matures.

Modular EUV Source for the next generation lithography

International Nuclear Information System (INIS)

Sublemontier, O.; Rosset-Kos, M.; Ceccotti, T.; Hergott, J.F.; Auguste, Th.; Normand, D.; Schmidt, M.; Beaumont, F.; Farcage, D.; Cheymol, G.; Le Caro, J.M.; Cormont, Ph.; Mauchien, P.; Thro, P.Y.; Skrzypczak, J.; Muller, S.; Marquis, E.; Barthod, B.; Gaurand, I.; Davenet, M.; Bernard, R.

2011-01-01

The present work, performed in the frame of the EXULITE project, was dedicated to the design and characterization of a laser-plasma-produced extreme ultraviolet (EUV) source prototype at 13.5 nm for the next generation lithography. It was conducted in cooperation with two laboratories from CEA, ALCATEL and THALES. One of our approach originalities was the laser scheme modularity. Six Nd:YAG laser beams were focused at the same time on a xenon filament jet to generate the EUV emitting plasma. Multiplexing has important industrial advantages and led to interesting source performances in terms of in-band power, stability and angular emission properties with the filament jet target. A maximum conversion efficiency (CE) value of 0.44% in 2π sr and 2% bandwidth was measured, which corresponds to a maximum in band EUV mean power of 7.7 W at a repetition rate of 6 kHz. The EUV emission was found to be stable and isotropic in these conditions. (authors)

Reducing Risk for the Next Generation Nuclear Plant

International Nuclear Information System (INIS)

Beck, John M. II; Heydt, Harold J.; Opare, Emmanuel O.; Oswald, Kyle B.

2010-01-01

The Next Generation Nuclear Plant (NGNP) Project, managed by the Idaho National Laboratory (INL), is directed by the Energy Policy Act of 2005, to research, develop, design, construct, and operate a prototype forth generation nuclear reactor to meet the needs of the 21st Century. As with all large projects developing and deploying new technologies, the NGNP has numerous risks that need to be identified, tracked, mitigated, and reduced in order for successful project completion. A Risk Management Plan (RMP) was created to outline the process the INL is using to manage the risks and reduction strategies for the NGNP Project. Integral to the RMP is the development and use of a Risk Management System (RMS). The RMS is a tool that supports management and monitoring of the project risks. The RMS does not only contain a risk register, but other functionality that allows decision makers, engineering staff, and technology researchers to review and monitor the risks as the project matures.

Next generation reactor development activity at Hitachi, Ltd

International Nuclear Information System (INIS)

Yamashita, Junichi

2005-01-01

Developments of innovative nuclear systems in Japan have been highly requested to cope with uncertain future nuclear power generation and fuel cycle situation. Next generation reactor system shall be surely deployed earlier to be capable to provide with several options such as plutonium multi-recycle, intermediate storage of spent fuels, simplified reprocessing of spent fuels and separated storage of 'Pu+FP' and 'U', spent fuels storage after Pu LWR recycle and their combinations, while future reactor system will be targeted at ideal fuel recycle system of higher breeding gain and transmutation of radioactive wastes. Modified designs of the ABWR at large size and medium and small size have been investigated as well as a BWR based RMWR and a supercritical-pressure LWR to ensure safety and improve economics. Advanced fuel cycle technologies of a combination of fluoride volatility process and PUREX process with high decontamination (FLUOREX process) and a modified fluoride volatility process with low decontamination have been developed. (T. Tanaka)

NIRS report of investigations for the development of the next generation PET apparatus. FY 2002

International Nuclear Information System (INIS)

2003-03-01

The present status of studies conducted by representative technology fields for the development of the next generation PET apparatus, and the summary of opinions given by investigators of nuclear medicine are reported. The former involves chapters of: Summary of representative technologies for the development of the next generation PET apparatus; Count rate analysis of PET apparatuses for the whole body and small animals by PET simulator; Scintillator; DOI (depth of interaction) detector-evaluation of the detector with 256-ch fluorescence polarization-photomultiplier tubes (FP-PMT) trial apparatus etc; Examination of multi-slice DOI-MR compatible detector for PET; Development of application specific integrated circuit (ASIC) for processing the front-end signals; Detector simulation; Circuit for processing PET detector signals; Signal processing-coincidence circuit; Data collection system; Signal processing technology for the next generation PET; Reconstruction of statistical PET image using DOI signals; Monte Carlo simulation and Unique directions-PET for infants and for the whole body autonomic nervous systems and mental activity; and Actual design and evaluation of image reconstruction by statistical means. Opinions are: Progress of clinical PET apparatus; Desirable PET drugs and apparatuses; From clinical practice for the development of the next generation PET apparatus; From clinical psychiatric studies for the development; From application of drug development and basic researches; From brain PET practice; From clinical PET practice; and The role of National Institute of Radiological Sciences (NIRS) in PET development. Also involved is the publication list. (N.I.)

Next Generation Computer Resources: Reference Model for Project Support Environments (Version 2.0)

National Research Council Canada - National Science Library

Brown, Alan

1993-01-01

The objective of the Next Generation Computer Resources (NGCR) program is to restructure the Navy's approach to acquisition of standard computing resources to take better advantage of commercial advances and investments...

Design of a fault diagnosis system for next generation nuclear power plants

International Nuclear Information System (INIS)

Zhao, K.; Upadhyaya, B.R.; Wood, R.T.

2004-01-01

A new design approach for fault diagnosis is developed for next generation nuclear power plants. In the nuclear reactor design phase, data reconciliation is used as an efficient tool to determine the measurement requirements to achieve the specified goal of fault diagnosis. In the reactor operation phase, the plant measurements are collected to estimate uncertain model parameters so that a high fidelity model can be obtained for fault diagnosis. The proposed algorithm of fault detection and isolation is able to combine the strength of first principle model based fault diagnosis and the historical data based fault diagnosis. Principal component analysis on the reconciled data is used to develop a statistical model for fault detection. The updating of the principal component model based on the most recent reconciled data is a locally linearized model around the current plant measurements, so that it is applicable to any generic nonlinear systems. The sensor fault diagnosis and process fault diagnosis are decoupled through considering the process fault diagnosis as a parameter estimation problem. The developed approach has been applied to the IRIS helical coil steam generator system to monitor the operational performance of individual steam generators. This approach is general enough to design fault diagnosis systems for the next generation nuclear power plants. (authors)

Composite Materials under Extreme Radiation and Temperature Environments of the Next Generation Nuclear Reactors

International Nuclear Information System (INIS)

Simos, N.

2011-01-01

In the nuclear energy renaissance, driven by fission reactor concepts utilizing very high temperatures and fast neutron spectra, materials with enhanced performance that exceeds are expected to play a central role. With the operating temperatures of the Generation III reactors bringing the classical reactor materials close to their performance limits there is an urgent need to develop and qualify new alloys and composites. Efforts have been focused on the intricate relations and the high demands placed on materials at the anticipated extreme states within the next generation fusion and fission reactors which combine high radiation fluxes, elevated temperatures and aggressive environments. While nuclear reactors have been in operation for several decades, the structural materials associated with the next generation options need to endure much higher temperatures (1200 C), higher neutron doses (tens of displacements per atom, dpa), and extremely corrosive environments, which are beyond the experience on materials accumulated to-date. The most important consideration is the performance and reliability of structural materials for both in-core and out-of-core functions. While there exists a great body of nuclear materials research and operating experience/performance from fission reactors where epithermal and thermal neutrons interact with materials and alter their physio-mechanical properties, a process that is well understood by now, there are no operating or even experimental facilities that will facilitate the extreme conditions of flux and temperature anticipated and thus provide insights into the behaviour of these well understood materials. Materials, however, still need to be developed and their interaction and damage potential or lifetime to be quantified for the next generation nuclear energy. Based on material development advances, composites, and in particular ceramic composites, seem to inherently possess properties suitable for key functions within the

Digital Earth reloaded - Beyond the next generation

Science.gov (United States)

Ehlers, M.; Woodgate, P.; Annoni, A.; Schade, S.

2014-02-01

Digital replicas (or 'mirror worlds') of complex entities and systems are now routine in many fields such as aerospace engineering; archaeology; medicine; or even fashion design. The Digital Earth (DE) concept as a digital replica of the entire planet occurs in Al Gore's 1992 book Earth in the Balance and was popularized in his speech at the California Science Center in January 1998. It played a pivotal role in stimulating the development of a first generation of virtual globes, typified by Google Earth that achieved many elements of this vision. Almost 15 years after Al Gore's speech, the concept of DE needs to be re-evaluated in the light of the many scientific and technical developments in the fields of information technology, data infrastructures, citizen?s participation, and earth observation that have taken place since. This paper intends to look beyond the next generation predominantly based on the developments of fields outside the spatial sciences, where concepts, software, and hardware with strong relationships to DE are being developed without referring to this term. It also presents a number of guiding criteria for future DE developments.

Technology Innovations from NASA's Next Generation Launch Technology Program

Science.gov (United States)

Cook, Stephen A.; Morris, Charles E. K., Jr.; Tyson, Richard W.

2004-01-01

NASA's Next Generation Launch Technology Program has been on the cutting edge of technology, improving the safety, affordability, and reliability of future space-launch-transportation systems. The array of projects focused on propulsion, airframe, and other vehicle systems. Achievements range from building miniature fuel/oxygen sensors to hot-firings of major rocket-engine systems as well as extreme thermo-mechanical testing of large-scale structures. Results to date have significantly advanced technology readiness for future space-launch systems using either airbreathing or rocket propulsion.

Application of photonics in next generation telecommunication satellites payloads

Science.gov (United States)

Anzalchi, J.; Inigo, P.; Roy, B.

2017-11-01

Next generation broadband telecommunication satellites are required to provide very high data throughput using complex multibeam architectures. These high throughput `Terabit/s' Satellites will incorporate payloads with very large quantity of conventional RF equipment, co-axial cables, waveguides, harnesses and ancillary equipment, making the Assembly, Integration and Test (AIT) very complex. Use of `RF over Fiber' and associated photonics equipment can make the process of AIT much simpler with the added benefit of significant reduction in number of payload equipment and inherent payload mass.

Precision Controlled Carbon Materials for Next-Generation Optoelectronic and Photonic Devices

Science.gov (United States)

2018-01-08

engineer next-generation carbon-based optoelectronic and photonic devices with superior performance and capabilities. These devices include carbon...electronics; (4) nanostructured graphene plasmonics; and (5) polymer-nanotube conjugate chemistry . (1) Semiconducting carbon nanotube-based...applications (In Preparation, 2018). (5) Polymer-nanotube conjugate chemistry Conjugated polymers can be exploited as agents for selectively wrapping and

Compliance uncertainty of diameter characteristic in the next-generation geometrical product specifications and verification

International Nuclear Information System (INIS)

Lu, W L; Jiang, X; Liu, X J; Xu, Z G

2008-01-01

Compliance uncertainty is one of the most important elements in the next-generation geometrical product specifications and verification (GPS). It consists of specification uncertainty, method uncertainty and implementation uncertainty, which are three of the four fundamental uncertainties in the next-generation GPS. This paper analyzes the key factors that influence compliance uncertainty and then proposes a procedure to manage the compliance uncertainty. A general model on evaluation of compliance uncertainty has been devised and a specific formula for diameter characteristic has been derived based on this general model. The case study was conducted and it revealed that the completeness of currently dominant diameter characteristic specification needs to be improved

Next generation platforms for high-throughput bio-dosimetry

International Nuclear Information System (INIS)

Repin, Mikhail; Turner, Helen C.; Garty, Guy; Brenner, David J.

2014-01-01

Here the general concept of the combined use of plates and tubes in racks compatible with the American National Standards Institute/the Society for Laboratory Automation and Screening microplate formats as the next generation platforms for increasing the throughput of bio-dosimetry assays was described. These platforms can be used at different stages of bio-dosimetry assays starting from blood collection into micro-tubes organised in standardised racks and ending with the cytogenetic analysis of samples in standardised multi-well and multichannel plates. Robotically friendly platforms can be used for different bio-dosimetry assays in minimally equipped laboratories and on cost-effective automated universal biotech systems. (authors)

Traffic Management for Next Generation Transport Networks

DEFF Research Database (Denmark)

Yu, Hao

required by the next generation transport network to provide Quality-of-Service (QoS) guaranteed video services. Augmenting network capacity and upgrading network nodes indicate long deployment period, replacement of equipment and thus significant cost to the network service providers. This challenge may...... slacken the steps of some network operators towards providing IPTV services. In this dissertation, the topology-based hierarchical scheduling scheme is proposed to tackle the problem addressed. The scheme simplifies the deployment process by placing an intelligent switch with centralized traffic...... management functions at the edge of the network, scheduling traffic on behalf of the other nodes. The topology-based hierarchical scheduling scheme is able to provide outstanding flow isolation due to its centralized scheduling ability, which is essential for providing IPTV services. In order to reduce...

Envisioning the Next Generation of Behavioral Health and Criminal Justice Interventions

Science.gov (United States)

Epperson, Matthew W.; Wolff, Nancy; Morgan, Robert D.; Fisher, William H.; Frueh, B. Christopher; Huening, Jessica

2014-01-01

The purpose of this paper is to cast a vision for the next generation of behavioral health and criminal justice interventions for persons with serious mental illnesses in the criminal justice system. The limitations of first generation interventions, including their primary focus on mental health treatment connection, are discussed. A person-place framework for understanding the complex factors that contribute to criminal justice involvement for this population is presented. We discuss practice and research recommendations for building more effective interventions to address both criminal justice and mental health outcomes. PMID:24666731

Next-Generation Library Catalogs and the Problem of Slow Response Time

Directory of Open Access Journals (Sweden)

Margaret Brown-Sica

2010-12-01

Full Text Available Response time as defined for this study is the time that it takes for all files that constitute a single webpage to travel across the Internet from a Web server to the end user’s browser. In this study, the authors tested response times on queries for identical items in five different library catalogs, one of them a next-generation (NextGen catalog. The authors also discuss acceptable response time and how it may affect the discovery process. They suggest that librarians and vendors should develop standards for acceptable response time and use it in the product selection and development processes.

Tracing the Baryon Cycle within Nearby Galaxies with a next-generation VLA

Science.gov (United States)

Kepley, Amanda A.; Leroy, Adam; Murphy, Eric J.; ngVLA Baryon Cycle Science Working Group

2017-01-01

The evolution of galaxies over cosmic time is shaped by the cycling of baryons through these systems, namely the inflow of atomic gas, the formation of molecular structures, the birth of stars, and the expulsion of gas due to associated feedback processes. The best way to study this cycle in detail are observations of nearby galaxies. These systems provide a complete picture of baryon cycling over a wide range of astrophysical conditions. In the next decade, higher resolution/sensitivity observations of such galaxies will fundamentally improve our knowledge of galaxy formation and evolution, allowing us to better interpret higher redshift observations of sources that were rapidly evolving at epochs soon after the Big Bang. In particular, the centimeter-to-millimeter part of the spectrum provides critical diagnostics for each of the key baryon cycling processes and access to almost all phases of gas in galaxies: cool and cold gas (via emission and absorption lines), ionized gas (via free-free continuum and recombination lines), cosmic rays and hot gas (via synchrotron emission and the Sunyaev-Zeldovich effect). This poster highlights a number of key science problems in this area whose solutions require a next-generation radio-mm interferometer such as the next-generation VLA.

Next Generation Space Surveillance System-of-Systems

Science.gov (United States)

McShane, B.

2014-09-01

International economic and military dependence on space assets is pervasive and ever-growing in an environment that is now congested, contested, and competitive. There are a number of natural and man-made risks that need to be monitored and characterized to protect and preserve the space environment and the assets within it. Unfortunately, today's space surveillance network (SSN) has gaps in coverage, is not resilient, and has a growing number of objects that get lost. Risks can be efficiently and effectively mitigated, gaps closed, resiliency improved, and performance increased within a next generation space surveillance network implemented as a system-of-systems with modern information architectures and analytic techniques. This also includes consideration for the newest SSN sensors (e.g. Space Fence) which are born Net-Centric out-of-the-box and able to seamlessly interface with the JSpOC Mission System, global information grid, and future unanticipated users. Significant opportunity exists to integrate legacy, traditional, and non-traditional sensors into a larger space system-of-systems (including command and control centers) for multiple clients through low cost sustainment, modification, and modernization efforts. Clients include operations centers (e.g. JSpOC, USSTRATCOM, CANSPOC), Intelligence centers (e.g. NASIC), space surveillance sensor sites (e.g. AMOS, GEODSS), international governments (e.g. Germany, UK), space agencies (e.g. NASA), and academic institutions. Each has differing priorities, networks, data needs, timeliness, security, accuracy requirements and formats. Enabling processes and technologies include: Standardized and type accredited methods for secure connections to multiple networks, machine-to-machine interfaces for near real-time data sharing and tip-and-queue activities, common data models for analytical processing across multiple radar and optical sensor types, an efficient way to automatically translate between differing client and

Challenges and opportunities in estimating viral genetic diversity from next-generation sequencing data

Directory of Open Access Journals (Sweden)

Niko eBeerenwinkel

2012-09-01

Full Text Available Many viruses, including the clinically relevant RNA viruses HIV and HCV, exist in large populations and display high genetic heterogeneity within and between infected hosts. Assessing intra-patient viral genetic diversity is essential for understanding the evolutionary dynamics of viruses, for designing effective vaccines, and for the success of antiviral therapy. Next-generation sequencing technologies allow the rapid and cost-effective acquisition of thousands to millions of short DNA sequences from a single sample. However, this approach entails several challenges in experimental design and computational data analysis. Here, we review the entire process of inferring viral diversity from sample collection to computing measures of genetic diversity. We discuss sample preparation, including reverse transcription and amplification, and the effect of experimental conditions on diversity estimates due to in vitro base substitutions, insertions, deletions, and recombination. The use of different next-generation sequencing platforms and their sequencing error profiles are compared in the context of various applications of diversity estimation, ranging from the detection of single nucleotide variants to the reconstruction of whole-genome haplotypes. We describe the statistical and computational challenges arising from these technical artifacts, and we review existing approaches, including available software, for their solution. Finally, we discuss open problems, and highlight successful biomedical applications and potential future clinical use of next-generation sequencing to estimate viral diversity.

Next-Generation Sequencing and Genome Editing in Plant Virology

Directory of Open Access Journals (Sweden)

Ahmed Hadidi

2016-08-01

Full Text Available Next-generation sequencing (NGS has been applied to plant virology since 2009. NGS provides highly efficient, rapid, low cost DNA or RNA high-throughput sequencing of the genomes of plant viruses and viroids and of the specific small RNAs generated during the infection process. These small RNAs, which cover frequently the whole genome of the infectious agent, are 21-24 nt long and are known as vsRNAs for viruses and vd-sRNAs for viroids. NGS has been used in a number of studies in plant virology including, but not limited to, discovery of novel viruses and viroids as well as detection and identification of those pathogens already known, analysis of genome diversity and evolution, and study of pathogen epidemiology. The genome engineering editing method, clustered regularly interspaced short palindromic repeats (CRISPR-Cas9 system has been successfully used recently to engineer resistance to DNA geminiviruses (family, Geminiviridae by targeting different viral genome sequences in infected Nicotiana benthamiana or Arabidopsis plants. The DNA viruses targeted include tomato yellow leaf curl virus and merremia mosaic virus (begomovirus; beet curly top virus and beet severe curly top virus (curtovirus; and bean yellow dwarf virus (mastrevirus. The technique has also been used against the RNA viruses zucchini yellow mosaic virus, papaya ringspot virus and turnip mosaic virus (potyvirus and cucumber vein yellowing virus (ipomovirus, family, Potyviridae by targeting the translation initiation genes eIF4E in cucumber or Arabidopsis plants. From these recent advances of major importance, it is expected that NGS and CRISPR-Cas technologies will play a significant role in the very near future in advancing the field of plant virology and connecting it with other related fields of biology.Keywords: Next-generation sequencing, NGS, plant virology, plant viruses, viroids, resistance to plant viruses by CRISPR-Cas9

Next to leading order three jet production at hadron colliders

International Nuclear Information System (INIS)

Kilgore, W.

1997-01-01

Results from a next-to-leading order event generator of purely gluonic jet production are presented. This calculation is the first step in the construction of a full next-to-leading order calculation of three jet production at hadron colliders. Several jet algorithms commonly used in experiments are implemented and their numerical stability is investigated. A numerical instability is found in the iterative cone algorithm which makes it inappropriate for use in fixed order calculations beyond leading order. (author)

Preparing the Next Generation of Higher Education Faculty in Special Education

Science.gov (United States)

deBettencourt, Laurie U.

2014-01-01

There is a shortage in the number of funded doctoral programs in the field of special education. As a result the number of higher education faculty who are trained in the knowledge and skills necessary to train the next generation of special education teachers is critically low. This article describes a doctoral program funded by the Office of…

Wireless next generation networks a virtue-based trust model

CERN Document Server

Harvey, Melissa

2014-01-01

This SpringerBrief proposes a trust model motivated by virtue epistemology, addressing the need for a more efficient and flexible trust model for wireless next generation networks. This theory of trust simplifies the computation and communication overhead of strictly cognitive-computational models of trust. Both the advantages and the challenges of virtue-based trust models are discussed. This brief offers new research and a general theory of rationality that enables users to interpret trust and reason as complementary mechanisms that guide our rational conduct at two different epistemic level

Use of next-generation sequencing in oral cavity cancer

DEFF Research Database (Denmark)

Tabatabaeifar, Siavosh; Kruse, Torben A; Thomassen, Mads

Background: Oral cavity cancer is a subgroup of head and neck cancer which is the world’s 6th most common cancer form. Oral squamous cell carcinomas (OSCC) constitute almost all oral cavity cancers, and OSCC are primarily attributed by excessive alcohol consumption and tobacco exposure...... of tumour cells exists. Conclusions: Use of next generation sequencing in oral cavity cancer can give valuable insight into the biology of the disease. By investigating intra tumour heterogeneity we see that the different tumour specimens in each patient are quite homogenous, but evidence of heterogeneous...

lociNGS: a lightweight alternative for assessing suitability of next-generation loci for evolutionary analysis.

Directory of Open Access Journals (Sweden)

Sarah M Hird

Full Text Available Genomic enrichment methods and next-generation sequencing produce uneven coverage for the portions of the genome (the loci they target; this information is essential for ascertaining the suitability of each locus for further analysis. lociNGS is a user-friendly accessory program that takes multi-FASTA formatted loci, next-generation sequence alignments and demographic data as input and collates, displays and outputs information about the data. Summary information includes the parameters coverage per locus, coverage per individual and number of polymorphic sites, among others. The program can output the raw sequences used to call loci from next-generation sequencing data. lociNGS also reformats subsets of loci in three commonly used formats for multi-locus phylogeographic and population genetics analyses - NEXUS, IMa2 and Migrate. lociNGS is available at https://github.com/SHird/lociNGS and is dependent on installation of MongoDB (freely available at http://www.mongodb.org/downloads. lociNGS is written in Python and is supported on MacOSX and Unix; it is distributed under a GNU General Public License.

Performance analysis of next-generation lunar laser retroreflectors

Science.gov (United States)

Ciocci, Emanuele; Martini, Manuele; Contessa, Stefania; Porcelli, Luca; Mastrofini, Marco; Currie, Douglas; Delle Monache, Giovanni; Dell'Agnello, Simone

2017-09-01

Starting from 1969, Lunar Laser Ranging (LLR) to the Apollo and Lunokhod Cube Corner Retroreflectors (CCRs) provided several tests of General Relativity (GR). When deployed, the Apollo/Lunokhod CCRs design contributed only a negligible fraction of the ranging error budget. Today the improvement over the years in the laser ground stations makes the lunar libration contribution relevant. So the libration now dominates the error budget limiting the precision of the experimental tests of gravitational theories. The MoonLIGHT-2 project (Moon Laser Instrumentation for General relativity High-accuracy Tests - Phase 2) is a next-generation LLR payload developed by the Satellite/lunar/GNSS laser ranging/altimetry and Cube/microsat Characterization Facilities Laboratory (SCF _ Lab) at the INFN-LNF in collaboration with the University of Maryland. With its unique design consisting of a single large CCR unaffected by librations, MoonLIGHT-2 can significantly reduce error contribution of the reflectors to the measurement of the lunar geodetic precession and other GR tests compared to Apollo/Lunokhod CCRs. This paper treats only this specific next-generation lunar laser retroreflector (MoonLIGHT-2) and it is by no means intended to address other contributions to the global LLR error budget. MoonLIGHT-2 is approved to be launched with the Moon Express 1(MEX-1) mission and will be deployed on the Moon surface in 2018. To validate/optimize MoonLIGHT-2, the SCF _ Lab is carrying out a unique experimental test called SCF-Test: the concurrent measurement of the optical Far Field Diffraction Pattern (FFDP) and the temperature distribution of the CCR under thermal conditions produced with a close-match solar simulator and simulated space environment. The focus of this paper is to describe the SCF _ Lab specialized characterization of the performance of our next-generation LLR payload. While this payload will improve the contribution of the error budget of the space segment (MoonLIGHT-2

Next generation tools for genomic data generation, distribution, and visualization.

Science.gov (United States)

Nix, David A; Di Sera, Tonya L; Dalley, Brian K; Milash, Brett A; Cundick, Robert M; Quinn, Kevin S; Courdy, Samir J

2010-09-09

With the rapidly falling cost and availability of high throughput sequencing and microarray technologies, the bottleneck for effectively using genomic analysis in the laboratory and clinic is shifting to one of effectively managing, analyzing, and sharing genomic data. Here we present three open-source, platform independent, software tools for generating, analyzing, distributing, and visualizing genomic data. These include a next generation sequencing/microarray LIMS and analysis project center (GNomEx); an application for annotating and programmatically distributing genomic data using the community vetted DAS/2 data exchange protocol (GenoPub); and a standalone Java Swing application (GWrap) that makes cutting edge command line analysis tools available to those who prefer graphical user interfaces. Both GNomEx and GenoPub use the rich client Flex/Flash web browser interface to interact with Java classes and a relational database on a remote server. Both employ a public-private user-group security model enabling controlled distribution of patient and unpublished data alongside public resources. As such, they function as genomic data repositories that can be accessed manually or programmatically through DAS/2-enabled client applications such as the Integrated Genome Browser. These tools have gained wide use in our core facilities, research laboratories and clinics and are freely available for non-profit use. See http://sourceforge.net/projects/gnomex/, http://sourceforge.net/projects/genoviz/, and http://sourceforge.net/projects/useq.

Sensor-Generated Time Series Events: A Definition Language

Science.gov (United States)

Anguera, Aurea; Lara, Juan A.; Lizcano, David; Martínez, Maria Aurora; Pazos, Juan

2012-01-01

There are now a great many domains where information is recorded by sensors over a limited time period or on a permanent basis. This data flow leads to sequences of data known as time series. In many domains, like seismography or medicine, time series analysis focuses on particular regions of interest, known as events, whereas the remainder of the time series contains hardly any useful information. In these domains, there is a need for mechanisms to identify and locate such events. In this paper, we propose an events definition language that is general enough to be used to easily and naturally define events in time series recorded by sensors in any domain. The proposed language has been applied to the definition of time series events generated within the branch of medicine dealing with balance-related functions in human beings. A device, called posturograph, is used to study balance-related functions. The platform has four sensors that record the pressure intensity being exerted on the platform, generating four interrelated time series. As opposed to the existing ad hoc proposals, the results confirm that the proposed language is valid, that is generally applicable and accurate, for identifying the events contained in the time series.

Next-generation leadership development in family businesses: the critical roles of shared vision and family climate.