Newly Developed Ceramic Membranes for Dehydration and Separation of Organic Mixtures by Pervaporation

NARCIS (Netherlands)

Gemert, van R.W.; Cuperus, F.P.

1995-01-01

Polymeric pervaporation membranes sometimes show great variety in performance when they are alternately used for different solvent mixtures. In addition, membrane stability in time is a problem in case of some solvents. Therefore, newly developed ceramic silica membranes with a 'dense' top layer

R/D and implement of temper bead welding as newly developed maintenance technique in nuclear power plant

International Nuclear Information System (INIS)

Hirano, Shinro; Sera, Takehiko; Chigusa, Naoki; Okimura, Koji; Nishimoto, Kazutoshi

2011-01-01

Japanese government has recently addressed a policy to increase capacity factor of existing nuclear PPs to achieve the goal to decrease the emission of CO 2 . Numerous preventive measures have taken in nuclear power plants to minimize the risk of unexpected long shutdown. Newly developed mitigation measures or repair methods need to be qualified to satisfy regulatory standards, before it is implemented to nuclear power plants. The qualification process needs to comply regulatory standards though it may consume time to go through each of the required steps. This paper describes such cases namely ambient temper-bead welding and clarifies the issues that need to be resolved regarding qualification process. The qualification process for new methods that has not been prescribed in regulatory standards temporarily completed by go through confirm testing by JAPEIC, RNP and issuance of no action letter in rush. Currently, the qualification process can only be applied on limited area so generalized qualification process needs to be established. (author)

The Development Needs of Newly Appointed Senior School Leaders in the Western Cape South Africa: A Case Study

Directory of Open Access Journals (Sweden)

Nelius Jansen van Vuuren

2017-12-01

Full Text Available The essential role that senior school leaders play in school leadership teams to ensure effective strategic leadership in schools has been the subject of intense discussion for many years. Crucial to this debate is the establishment of professional learning and leadership approaches for newly appointed senior school leaders. Recommendations for policy and practice highlight the importance of appropriate, multifaceted, developmental support initiatives for newly appointed school leaders. In many countries, including South Africa, a teaching qualification and, in most cases, extensive teaching experience is the only requirement for being appointed as a senior school leader in a school. This tends to suggest that no further professional development is required for newly appointed school leaders, the problem addressed in this paper. This paper reports on the main findings of the perceived development needs of newly appointed senior school leaders in the Western Cape, South Africa, and suggests that school leaders occupy a unique and specialist role in education, which requires relevant and specific preparation to support effective leadership. The respondents of this study report a lack of contextualised training and support before and after their appointment in their new roles creating unique development needs. This paper, therefore, employs a mixed-method approach to gather data to understand the perceived needs of twenty newly appointed senior school leaders in the Western Cape, South Africa.

A model for mentoring newly-appointed nurse educators in nursing education institutions in South Africa.

Science.gov (United States)

Seekoe, Eunice

2014-04-24

South Africa transformed higher education through the enactment of the Higher Education Act (No. 101 of 1997). The researcher identified the need to develop a model for the mentoring of newly-appointed nurse educators in nursing education institutions in South Africa.  To develop and describe the model for mentoring newly-appointed nurse educators in nursing education institutions in South Africa.  A qualitative and theory-generating design was used (following empirical findings regarding needs analysis) in order to develop the model. The conceptualisation of the framework focused on the context, content, process and the theoretical domains that influenced the model. Ideas from different theories were borrowed from and integrated with the literature and deductive and inductive strategies were applied.  The structure of the model is multidimensional and complex in nature (macro, mesoand micro) based on the philosophy of reflective practice, competency-based practice andcritical learning theories. The assumptions are in relation to stakeholders, context, mentoring, outcome, process and dynamic. The stakeholders are the mentor and mentee within an interactive participatory relationship. The mentoring takes place within the process with a sequence of activities such as relationship building, development, engagement, reflective process and assessment. Capacity building and empowerment are outcomes of mentoring driven by motivation.  The implication for nurse managers is that the model can be used to develop mentoring programmes for newly-appointed nurse educators.

Competence of newly qualified registered nurses from a nursing college

Directory of Open Access Journals (Sweden)

BG Morolong

2005-09-01

Full Text Available The South African education and training system, through its policy of outcomesbased education and training, has made competency a national priority. In compliance to this national requirement of producing competent learners, the South African Nursing Council ( 1999 B require that the beginner professional nurse practitioners and midwives have the necessary knowledge, skills, attitudes and values which will enable them to render efficient professional service. The health care system also demands competent nurse practitioners to ensure quality in health care. In the light of competency being a national priority and a statutory demand, the research question that emerges is, how competent are the newly qualified registered nurses from a specific nursing college in clinical nursing education? A quantitative, non-experimental contextual design was used to evaluate the competence of newly qualified registered nurses from a specific nursing college. The study was conducted in two phases. The first phase dealt with the development of an instrument together with its manual through the conceptualisation process. The second phase focused on the evaluation of the competency of newly qualified nurses using the instrument based on the steps of the nursing process. A pilot study was conducted to test the feasibility of the items of the instrument. During the evaluation phase, a sample of twenty-six newly qualified nurses was selected by simple random sampling from a target population of thirty-six newly qualified registered nurses. However, six participants withdrew from the study. Data was collected in two general hospitals where the newly qualified registered nurses were working. Observation and questioning were used as data collection techniques in accordance with the developed instrument. Measures were taken to ensure internal validity and reliability of the results. To protect the rights of the participants, the researcher adhered to DENOSA’S (1998

A Newly Developed Method for Computing Reliability Measures in a Water Supply Network

Directory of Open Access Journals (Sweden)

Jacek Malinowski

2016-01-01

Full Text Available A reliability model of a water supply network has beens examined. Its main features are: a topology that can be decomposed by the so-called state factorization into a (relativelysmall number of derivative networks, each having a series-parallel structure (1, binary-state components (either operative or failed with given flow capacities (2, a multi-state character of the whole network and its sub-networks - a network state is defined as the maximal flow between a source (sources and a sink (sinks (3, all capacities (component, network, and sub-network have integer values (4. As the network operates, its state changes due to component failures, repairs, and replacements. A newly developed method of computing the inter-state transition intensities has been presented. It is based on the so-called state factorization and series-parallel aggregation. The analysis of these intensities shows that the failure-repair process of the considered system is an asymptotically homogenous Markov process. It is also demonstrated how certain reliability parameters useful for the network maintenance planning can be determined on the basis of the asymptotic intensities. For better understanding of the presented method, an illustrative example is given. (original abstract

Validating self-reported mobile phone use in adults using a newly developed smartphone application

NARCIS (Netherlands)

Goedhart, Geertje; Kromhout, Hans; Wiart, Joe; Vermeulen, Roel

2015-01-01

OBJECTIVE: Interpretation of epidemiological studies on health effects from mobile phone use is hindered by uncertainties in the exposure assessment. We used a newly developed smartphone application (app) to validate self-reported mobile phone use and behaviour among adults. METHODS: 107

The practical skills of newly qualified nurses.

Science.gov (United States)

Danbjørg, Dorthe Boe; Birkelund, Regner

2011-02-01

This paper reports the findings from a study of newly qualified nurses and which subjects the nurses regarded as the most important in order to be able to live up to the requirements of clinical practice, and how they experience their potential for developing practical and moral skills, after the decrease in practical training. A qualitative approach guided the research process and the analysis of the data. The data was collected by participant observation and qualitative interviews with four nurses as informants. The conclusions made in this study are based on the statements and the observations of the newly qualified nurses. Our findings are discussed in relation to the Aristotelian concept and other relevant literature. The main message is that the newly qualified nurses did not feel equipped when they finished their training. This could be interpreted as a direct consequence of the decrease in practical training. Our study also underlines that the way nursing theory is perceived and taught is problematic. The interviews revealed that the nurses think that nursing theories should be applied directly in practice. This misunderstanding is probably also applicable to the teachers of the theories. Copyright © 2010 Elsevier Ltd. All rights reserved.

Micro-computed tomography newly developed for in vivo small animal imaging

International Nuclear Information System (INIS)

Arai, Yoshinori; Ninomiya, Tadashi; Kato, Takafumi; Masuda, Yuji

2005-01-01

The aim of this paper is to report a newly developed micro-computed tomography system for in vivo use. The system was composed of a micro-focus X-ray tube and an image intensifier (I.I.), both of which rotated around the object stage. A guinea pig and a rat were examined. The anesthetized animal was set on the secure object stage. Images of the head of the guinea pig and the tibia knee joint of the rat were taken. In addition, an image of the rat's tail was taken. The reconstruction and the image viewing were carried out using I-View software. The voxel matrix was 512 x 512 x 384. The voxel sizes ranged from 10 x 10 x 10 μm to 100 x 100 x 100 μm. The exposure time was 17 s, and the reconstruction time was 150 s. The head of the guinea pig and the tibia/knee joint of the rat were observed clearly under 100-μm and 30μm voxels, respectively. The trabecular bone of the tail was also observed clearly under a 10 μm voxel. The newly developed micro-computed tomography system makes it possible to obtain images of anesthetized animals set on a secure object stage. Clear bone images of the small animals could be obtained within a short time. (author)

Process development for scum to biodiesel conversion.

Science.gov (United States)

Bi, Chong-hao; Min, Min; Nie, Yong; Xie, Qing-long; Lu, Qian; Deng, Xiang-yuan; Anderson, Erik; Li, Dong; Chen, Paul; Ruan, Roger

2015-06-01

A novel process was developed for converting scum, a waste material from wastewater treatment facilities, to biodiesel. Scum is an oily waste that was skimmed from the surface of primary and secondary settling tanks in wastewater treatment plants. Currently scum is treated either by anaerobic digestion or landfilling which raised several environmental issues. The newly developed process used a six-step method to convert scum to biodiesel, a higher value product. A combination of acid washing and acid catalyzed esterification was developed to remove soap and impurities while converting free fatty acids to methyl esters. A glycerol washing was used to facilitate the separation of biodiesel and glycerin after base catalyzed transesterification. As a result, 70% of dried and filtered scum was converted to biodiesel which is equivalent to about 134,000 gallon biodiesel per year for the Saint Paul waste water treatment plant in Minnesota. Copyright © 2015 Elsevier Ltd. All rights reserved.

Assessing College Students' Perceptions of a Case Teacher's Pedagogical Content Knowledge Using a Newly Developed Instrument

Science.gov (United States)

Jang, Syh-Jong

2011-01-01

Ongoing professional development for college teachers has been much emphasized. However, previous research on learning environments has seldom addressed college students' perceptions of teachers' PCK. This study aimed to evaluate college students' perceptions of a physics teacher's PCK development using a newly developed instrument and workshop…

A Process Perspective on Regulation: A Grounded Theory Study into Regulatory Practice in Newly Liberalized Network-Based Markets

NARCIS (Netherlands)

Ubacht, J.

The transition from a former monopolistic towards a more competitive market in
newly liberalized network-based markets raises regulatory issues. National Regulatory Authorities (NRA) face the challenge to deal with these issues in order to guide the transition process. Although this transition

A model for mentoring newly-appointed nurse educators in nursing education institutions in South Africa

Directory of Open Access Journals (Sweden)

Eunice Seekoe

2014-02-01

Full Text Available Background: South Africa transformed higher education through the enactment of the Higher Education Act (No. 101 of 1997. The researcher identified the need to develop a model for the mentoring of newly-appointed nurse educators in nursing education institutions in South Africa. Objectives: To develop and describe the model for mentoring newly-appointed nurse educators in nursing education institutions in South Africa. Method: A qualitative and theory-generating design was used (following empirical findings regarding needs analysis in order to develop the model. The conceptualisation of the framework focused on the context, content, process and the theoretical domains that influenced the model. Ideas from different theories were borrowed from and integrated with the literature and deductive and inductive strategies were applied. Results: The structure of the model is multidimensional and complex in nature (macro, mesoand micro based on the philosophy of reflective practice, competency-based practice andcritical learning theories. The assumptions are in relation to stakeholders, context, mentoring, outcome, process and dynamic. The stakeholders are the mentor and mentee within an interactive participatory relationship. The mentoring takes place within the process with a sequence of activities such as relationship building, development, engagement, reflective process and assessment. Capacity building and empowerment are outcomes of mentoring driven by motivation. Conclusion: The implication for nurse managers is that the model can be used to develop mentoring programmes for newly-appointed nurse educators.

Applicability of newly developed 610MPa class heavy thickness high strength steel to boiler pressure vessel

Energy Technology Data Exchange (ETDEWEB)

Katayama, Norihiko; Kaihara, Shoichiro; Ishii, Jun [Ishikawajima-Harima Heavy Industries Corp., Yokohama (Japan); Kajigaya, Ichiro [Ishikawajima-Harima Heavy Industries Corp., Tokyo (Japan); Totsuka, Takehiro; Miyazaki, Takashi [Ishikawajima-Harima Heavy Industries Corp., Aioi (Japan)

1995-11-01

Construction of a 350 MW Class PFBC (Pressurized Fluidized Bed Combustion) boiler plant is under planning in Japan. Design temperature and pressure of the vessel are maximum 350 C and 1.69 MPa, respectively. As the plate thickness of the vessel exceeds over 100 mm, high strength steel plate of good weldability and less susceptible to reheat cracking was required and developed. The steel was aimed to satisfy the tensile strength over 610 MPa at 350 C after postweld heat treatment (PWHT), with good notch toughness. The authors investigated the welding performances of the newly developed steel by using 150 mm-thick plate welded by pulsed-MAG and SAW methods. It was confirmed that the newly developed steel and its welds possess sufficient strength and toughness after PWHT, and applicable to the actual pressure vessel.

Fundamental Characteristics of the Newly Developed ATA™ Membrane Dialyzer.

Science.gov (United States)

Sunohara, Takashi; Masuda, Toshiaki

2017-01-01

Dialysis membranes are often made from synthetic polymers, such as polysulfone. However, membranes made from cellulose triacetate have superior biocompatibility and have been used since the 1980s. On-line hemodiafiltration treatment accompanied by massive fluid replacement is increasingly being used in Europe and Japan, but cellulose triacetate is not suitable for this treatment. Our newly developed asymmetric triacetate membrane, the ATA™ membrane, substantially improved the filtration properties and blood compatibility because of the asymmetric structure and smooth surface of this cellulose acetate membrane. Key Message: The ATA membrane maintains its high permeability even after massive filtration and shows less temporal variation in its permeation performance, lower protein adsorption, and superior biocompatibility compared with conventional membranes. © 2017 S. Karger AG, Basel.

The effect of strain distribution on microstructural developments during forging in a newly developed nickel base superalloy

Energy Technology Data Exchange (ETDEWEB)

Buckingham, R.C. [Institute of Structural Materials, Swansea University, Bay Campus, Fabian Way, Swansea SA1 8EN (United Kingdom); Argyrakis, C.; Hardy, M.C. [Rolls-Royce plc, PO Box 31, Derby DE24 8BJ (United Kingdom); Birosca, S., E-mail: 522042@swansea.ac.uk [Institute of Structural Materials, Swansea University, Bay Campus, Fabian Way, Swansea SA1 8EN (United Kingdom)

2016-01-27

In the current study, the effect of strain distribution in a simple forging geometry on the propensity for recrystallization, and its impact on mechanical properties has been investigated in a newly developed experimental nickel-based superalloy. The new alloy was produced via a Powder Metallurgy (PM) route and was subsequently Hot Isostatic Processed (HIP), isothermally forged, and heat treated to produce a coarse grain microstructure with average grain size of 23–32 μm. The alloy was examined by means of Electron Back-Scatter Diffraction (EBSD) to characterise the microstructural features such as grain orientation and morphology, grain boundary characteristics and the identification of potential Prior Particle Boundaries (PPBs) throughout each stage of the processing route. Results at the central region of the cross-section plane parallel to the loading direction showed significant microstructural differences across the forging depth. This microstructural variation was found to be highly dependent on the value of local strain imparted during forging such that areas of low effective strain showed partial recrystallisation and a necklace grain structure was observed following heat treatment. Meanwhile, a fully recrystallised microstructure with no PPBs was observed in the areas of high strain values, in the central region of the forging.

PHL10/460: Cancerfacts.com - Vertical Portal with Newly Developed Health Profiler

OpenAIRE

Lenz, C; Brucksch, M

1999-01-01

Introduction Unlike general health portals such as WebMD and Drkoop.com that cover everything from the flu to heart disease, Silicon Valley-based cancerfacts.com is a so-called vertical portal. It covers only one small vertical niche of health care: cancer, and in particular, prostate cancer. As a value-added proprietary technology, the company offers its newly developed profile engine to health information retrievers. Methods Users are enabled to insert their specific medical information - r...

Design of an X-band accelerating structure using a newly developed structural optimization procedure

Energy Technology Data Exchange (ETDEWEB)

Huang, Xiaoxia [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China); University of Chinese Academy of Sciences, Beijing 100049 (China); Fang, Wencheng; Gu, Qiang [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China); Zhao, Zhentang, E-mail: zhaozhentang@sinap.ac.cn [Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China); University of Chinese Academy of Sciences, Beijing 100049 (China)

2017-05-11

An X-band high gradient accelerating structure is a challenging technology for implementation in advanced electron linear accelerator facilities. The present work discusses the design of an X-band accelerating structure for dedicated application to a compact hard X-ray free electron laser facility at the Shanghai Institute of Applied Physics, and numerous design optimizations are conducted with consideration for radio frequency (RF) breakdown, RF efficiency, short-range wakefields, and dipole/quadrupole field modes, to ensure good beam quality and a high accelerating gradient. The designed X-band accelerating structure is a constant gradient structure with a 4π/5 operating mode and input and output dual-feed couplers in a racetrack shape. The design process employs a newly developed effective optimization procedure for optimization of the X-band accelerating structure. In addition, the specific design of couplers providing high beam quality by eliminating dipole field components and reducing quadrupole field components is discussed in detail.

Technetium-99m carboxymethylcellulose: A newly developed fibre marker for gastric emptying studies

International Nuclear Information System (INIS)

Schade, J.H.; Hoving, J.; Brouweres, J.R.B.J.; Riedstra-van Gent, H.G.; Zijlstra, J.; Dijkstra, J.P.H.

1991-01-01

We report a study of technetium-99m-labelled carboxymethyl-cellulose ( 99m Tc-CMC) as a newly developed non-digestible marker of the solid phase of gastric contents. The radiosynthesis is simple and shows a high labelling efficiency. In vitro and in vivo experiments demonstrated stability of the marker in the gastrointestinal tract during the process of gastric emptying. The gastric half-emptying time in ten healthy volunteers of both sexes was 105±17 min (mean±SD). This rate of gastric emptying is similar to that of non-digestible solid-phase markers such as in vivo labelled 99m Tc-chicken liver or radio-iodinated cellulose. In comparison with digestible solid-phase markers such as 99m Tc-labelled pancake or 99m Tc-cooked egg, gastric emptying of 99m Tc-CMC occurred more slowly, confirming the expected behaviour of a non-digestible solid-phase marker. We conclude that 99m Tc-CMC has the advantage of a simple and rapid labelling procedure and may be useful for clinical studies of gastric emptying. (orig.)

Newly developed semi-empirical formulas for (p, α) at 17.9 MeV and ...

Indian Academy of Sciences (India)

Home; Journals; Pramana – Journal of Physics; Volume 74; Issue 6. Newly developed semi-empirical formulas for (, ) at 17.9 MeV and (, ) at 22.3 MeV reaction cross-sections. Eyyup Tel Abdullah Aydin E Gamze Aydin Abdullah Kaplan Ömer Yavaş İskender A Reyhancan. Research Articles Volume 74 Issue 6 June ...

The newly developed Toyota plug-in hybrid system

Energy Technology Data Exchange (ETDEWEB)

Takaoka, Toshifumi; Ichinose, Hiroki [Toyota Motor Corporation (Japan)

2010-07-01

Toyota has been introducing several hybrid vehicles (HV) as a countermeasure to the automobile's concerns, like CO2 reduction, energy security, and emission reduction in urban areas. A next step towards an even more effective solution for these concerns is a plug-in hybrid vehicle (PHV). This vehicle combines the advantages of electric vehicles (EV), which use clean electric energy, and HV, with it's high environmental potential and user- friendliness comparable to conventional vehicles, such as a long cruising range. This paper describes a newly developed plug-in hybrid system and its vehicle performance. This system uses a Li-ion battery with high energy density and has an affordable EV range without sacrificing cabin space. The vehicle achieves a CO2 emission of 59g/km and meets the most stringent emission regulations in the world. The new PHV is a forerunner of the large-scale mass production PHV two years later. PHVs have the potential to become popular as a realistic solution towards sustainable mobility by renewable electricity usage in the future. (orig.)

Los Alamos Plutonium Facility newly generated TRU waste certification

International Nuclear Information System (INIS)

Gruetzmacher, K.; Montoya, A.; Sinkule, B.; Maez, M.

1997-01-01

This paper presents an overview of the activities being planned and implemented to certify newly generated contact handled transuranic (TRU) waste produced by Los Alamos National Laboratory's (LANL's) Plutonium Facility. Certifying waste at the point of generation is the most important cost and labor saving step in the WIPP certification process. The pedigree of a waste item is best known by the originator of the waste and frees a site from expensive characterization activities such as those associated with legacy waste. Through a cooperative agreement with LANLs Waste Management Facility and under the umbrella of LANLs WIPP-related certification and quality assurance documents, the Plutonium Facility will be certifying its own newly generated waste. Some of the challenges faced by the Plutonium Facility in preparing to certify TRU waste include the modification and addition of procedures to meet WIPP requirements, standardizing packaging for TRU waste, collecting processing documentation from operations which produce TRU waste, and developing ways to modify waste streams which are not certifiable in their present form

How Schools Can Promote Healthy Development for Newly Arrived Immigrant and Refugee Adolescents: Research Priorities

Science.gov (United States)

McNeely, Clea A.; Morland, Lyn; Doty, S. Benjamin; Meschke, Laurie L.; Awad, Summer; Husain, Altaf; Nashwan, Ayat

2017-01-01

Background: The US education system must find creative and effective ways to foster the healthy development of the approximately 2 million newly arrived immigrant and refugee adolescents, many of whom contend with language barriers, limited prior education, trauma, and discrimination. We identify research priorities for promoting the school…

The construction of social identity in newly recruited nuclear engineering staff: A longitudinal study

International Nuclear Information System (INIS)

Nguyen, Lynda; Murphy, Glen; Chang, Artemis

2014-01-01

This study examines the process by which newly recruited nuclear engineering and technical staff came to understand, define, think, feel and behave within a distinct group that has a direct contribution to the organization's overall emphasis on a culture of reliability and system safety. In the field of organizational behavior the interactive model of social identity formation has been recently proposed to explain the process by which the internalization of shared norms and values occurs, an element critical in identity formation. Using this rich model of organizational behavior we analyzed multiple sources of data from nine new hires over a period of three years. This was done from the time they were employed to investigate the construction of social identity by new entrants entering into a complex organizational setting reflected in the context of a nuclear facility. Informed by our data analyses, we found support for the interactive model of social identity development and report the unexpected finding that a newly appointed member's age and level of experience appears to influence the manner in which they adapt, and assimilate into their surroundings. This study represents an important contribution to the safety and reliability literature as it provides a rich insight into the way newly recruited employees enact the process by which their identities are formed and hence act, particularly under conditions of duress or significant organizational disruption in complex organizational settings. - Highlights: • We examined how newly recruited nuclear engineer staff develop their social identity. • The study empirically examined the interactive model of social identity formation. • Innovative research strategies were used to capture rich primary data for all case studies. • Age and experience moderated internalization route and the social identity formation process

Newly developed chitosan-silver hybrid nanoparticles: biosafety and apoptosis induction in HepG2 cells

International Nuclear Information System (INIS)

El-Sherbiny, Ibrahim M.; Salih, Ehab; Yassin, Abdelrahman M.; Hafez, Elsayed E.

2016-01-01

The present study reports the biosafety assessment, the exact molecular effects, and apoptosis induction of newly developed chitosan-silver hybrid nanoparticles (Cs–Ag NPs) in HepG2 cells. The investigated hybrid NPs were green synthesized using Cs/grape leaves aqueous extract (Cs/GLE) or Cs/GLE NPs as reducing and stabilizing agents. The successful formation of Cs/GLE NPs and Cs–Ag hybrid NPs has been confirmed by UV–Vis spectrophotometry, FTIR spectroscopy, XRD, and HRTEM. From the TEM analysis, the prepared Cs/GLE NPs are uniform and spherical with an average size of 150 nm, and the AgNPs (5–10 nm) were formed mainly on their surface. The UV–Vis spectra of Cs–Ag NPs showed a surface plasmon resonance (SPR) peak at about 450 nm confirming their formation. The synthesized Cs–Ag NPs were found to be crystalline as shown by XRD patterns with fcc phase oriented along the (111), (200), (220), and (311) planes. The cytotoxicity patterns, the antiproliferative activities, and the possible mechanisms of anticancer activity at molecular level of the newly developed Cs–Ag hybrid NPs were investigated. Cytotoxicity patterns of all the preparations demonstrated that the nontoxic treatment concentrations are ranged from 0.39 to 50 %, and many of the newly prepared Cs–Ag hybrid NPs showed high anticancer activities against HpG2 cells, and induced cellular apoptosis by downregulating BCL2 gene and upregulating P53.Graphical Abstract

Newly developed chitosan-silver hybrid nanoparticles: biosafety and apoptosis induction in HepG2 cells

Energy Technology Data Exchange (ETDEWEB)

El-Sherbiny, Ibrahim M., E-mail: ielsherbiny@Zewailcity.edu.eg; Salih, Ehab [Zewail City of Science and Technology, Center for Materials Science (Egypt); Yassin, Abdelrahman M. [Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technology Applications, Biopharmaceutical Product Research Department (Egypt); Hafez, Elsayed E. [City of Scientific Research and Technology Applications, Plant Protection and Biomolecular Diagnosis Department (Egypt)

2016-07-15

The present study reports the biosafety assessment, the exact molecular effects, and apoptosis induction of newly developed chitosan-silver hybrid nanoparticles (Cs–Ag NPs) in HepG2 cells. The investigated hybrid NPs were green synthesized using Cs/grape leaves aqueous extract (Cs/GLE) or Cs/GLE NPs as reducing and stabilizing agents. The successful formation of Cs/GLE NPs and Cs–Ag hybrid NPs has been confirmed by UV–Vis spectrophotometry, FTIR spectroscopy, XRD, and HRTEM. From the TEM analysis, the prepared Cs/GLE NPs are uniform and spherical with an average size of 150 nm, and the AgNPs (5–10 nm) were formed mainly on their surface. The UV–Vis spectra of Cs–Ag NPs showed a surface plasmon resonance (SPR) peak at about 450 nm confirming their formation. The synthesized Cs–Ag NPs were found to be crystalline as shown by XRD patterns with fcc phase oriented along the (111), (200), (220), and (311) planes. The cytotoxicity patterns, the antiproliferative activities, and the possible mechanisms of anticancer activity at molecular level of the newly developed Cs–Ag hybrid NPs were investigated. Cytotoxicity patterns of all the preparations demonstrated that the nontoxic treatment concentrations are ranged from 0.39 to 50 %, and many of the newly prepared Cs–Ag hybrid NPs showed high anticancer activities against HpG2 cells, and induced cellular apoptosis by downregulating BCL2 gene and upregulating P53.Graphical Abstract.

Cross-Linking Mast Cell Specific Gangliosides Stimulates the Release of Newly Formed Lipid Mediators and Newly Synthesized Cytokines

Directory of Open Access Journals (Sweden)

Edismauro Garcia Freitas Filho

2016-01-01

Full Text Available Mast cells are immunoregulatory cells that participate in inflammatory processes. Cross-linking mast cell specific GD1b derived gangliosides by mAbAA4 results in partial activation of mast cells without the release of preformed mediators. The present study examines the release of newly formed and newly synthesized mediators following ganglioside cross-linking. Cross-linking the gangliosides with mAbAA4 released the newly formed lipid mediators, prostaglandins D2 and E2, without release of leukotrienes B4 and C4. The effect of cross-linking these gangliosides on the activation of enzymes in the arachidonate cascade was then investigated. Ganglioside cross-linking resulted in phosphorylation of cytosolic phospholipase A2 and increased expression of cyclooxygenase-2. Translocation of 5-lipoxygenase from the cytosol to the nucleus was not induced by ganglioside cross-linking. Cross-linking of GD1b derived gangliosides also resulted in the release of the newly synthesized mediators, interleukin-4, interleukin-6, and TNF-α. The effect of cross-linking the gangliosides on the MAP kinase pathway was then investigated. Cross-linking the gangliosides induced the phosphorylation of ERK1/2, JNK1/2, and p38 as well as activating both NFκB and NFAT in a Syk-dependent manner. Therefore, cross-linking the mast cell specific GD1b derived gangliosides results in the activation of signaling pathways that culminate with the release of newly formed and newly synthesized mediators.

Guidelines for developing certification programs for newly generated TRU waste

International Nuclear Information System (INIS)

Whitty, W.J.; Ostenak, C.A.; Pillay, K.K.S.; Geoffrion, R.R.

1983-05-01

These guidelines were prepared with direction from the US Department of Energy (DOE) Transuranic (TRU) Waste Management Program in support of the DOE effort to certify that newly generated TRU wastes meet the Waste Isolation Pilot Plant (WIPP) Waste Acceptance Criteria. The guidelines provide instructions for generic Certification Program preparation for TRU-waste generators preparing site-specific Certification Programs in response to WIPP requirements. The guidelines address all major aspects of a Certification Program that are necessary to satisfy the WIPP Waste Acceptance Criteria and their associated Compliance Requirements and Certification Quality Assurance Requirements. The details of the major element of a Certification Program, namely, the Certification Plan, are described. The Certification Plan relies on supporting data and control documentation to provide a traceable, auditable account of certification activities. Examples of specific parts of the Certification Plan illustrate the recommended degree of detail. Also, a brief description of generic waste processes related to certification activities is included

A newly development RIA for thyroid hormone autoantibodies (THAAb)

International Nuclear Information System (INIS)

Li Fengying; Gu Liqiong; Chen Xiayin; Jin Yan; Chen Shuxian; Zhang Qun; Qiu Hongxia; Yang Jingren; Zhao Yongju; Chen Mingdao

2004-01-01

Objective: To report a newly developed RIA for THAAb from this laboratory. Methods: The tested serum samples were cultured with labelled thyroid hormone analogous ( 125 I T 3 , 125 I T 4 ) for 16 hours. Antigen-antibody complex was precipitated with anti-human IgG (immune precipitation method) and radio-activity determined. Results: The mean positive rate of THAAb in healthy euthyroid controls (n=186) was only 1.07%. The mean positive rate in patients with thyroid disorders was 14.4% (mean rate 13.5% in hyperthyroid subjects, n=118 and mean rate 15.2% in hypothyroid subjects, n=72). The serum THAAb titer could be markedly lowered after adding non-labelled thyroid hormones (P 3 and FT 4 would be significantly lowered (P 3 , FT 4 levels. In patients with positive THAAb (about 14.4% in patients with all thyroid disorders), the FT 3 , FT 4 levels were best determined after PEG precipitation. (authors)

Muscle Attenuation Is Associated With Newly Developed Hypertension in Men of African Ancestry.

Science.gov (United States)

Zhao, Qian; Zmuda, Joseph M; Kuipers, Allison L; Bunker, Clareann H; Patrick, Alan L; Youk, Ada O; Miljkovic, Iva

2017-05-01

Increased ectopic adipose tissue infiltration in skeletal muscle is associated with insulin resistance and diabetes mellitus. We evaluated whether change in skeletal muscle adiposity predicts subsequent development of hypertension in men of African ancestry, a population sample understudied in previous studies. In the Tobago Health Study, a prospective longitudinal study among men of African ancestry (age range 40-91 years), calf intermuscular adipose tissue, and skeletal muscle attenuation were measured with computed tomography. Hypertension was defined as a systolic blood pressure ≥140 mm Hg, or a diastolic blood pressure ≥90 mm Hg, or receiving antihypertensive medications. Logistic regression was performed with adjustment for age, insulin resistance, baseline and 6-year change in body mass index, baseline and 6-year change in waist circumference, and other potential confounding factors. Among 746 normotensive men at baseline, 321 (43%) developed hypertension during the mean 6.2 years of follow-up. Decreased skeletal muscle attenuation was associated with newly developed hypertension after adjustment for baseline and 6-year change of body mass index (odds ratio [95% confidence interval] per SD, 1.3 [1.0-1.6]) or baseline and 6-year change of waist circumference (odds ratio [95% confidence interval] per SD, 1.3 [1.0-1.6]). No association was observed between increased intermuscular adipose tissue and hypertension. Our novel findings show that decreased muscle attenuation is associated with newly developed hypertension among men of African ancestry, independent of general and central adiposity and insulin resistance. Further studies are needed to adjust for inflammation, visceral and other ectopic adipose tissue depots, and to confirm our findings in other population samples. © 2017 American Heart Association, Inc.

The impact of organisational culture on the adaptation of newly ...

African Journals Online (AJOL)

Usually newly employed nurses find adjusting to a work setting a challenging experience. Their successful adaptation to their work situation is greatly influenced by the socialisation process inherent in the organisational culture. The newly employed nurse often finds that the norms are unclear, confusing and restrictive.

Newly-graduated midwives transcending barriers: a grounded theory study.

Science.gov (United States)

Barry, Michele J; Hauck, Yvonne L; O'Donoghue, Thomas; Clarke, Simon

2013-12-01

Midwifery has developed its own philosophy to formalise its unique identity as a profession. Newly-graduated midwives are taught, and ideally embrace, this philosophy during their education. However, embarking in their career within a predominantly institutionalised and the medically focused health-care model may challenge this application. The research question guiding this study was as follows: 'How do newly graduated midwives deal with applying the philosophy of midwifery in their first six months of practice?' The aim was to generate a grounded theory around this social process. This Western Australian grounded theory study is conceptualised within the social theory of symbolic interactionism. Data were collected by means of in-depth, semi-structured interviews with 11 recent midwifery graduates. Participant and interviewer's journals provided supplementary data. The 'constant comparison' approach was used for data analysis. The substantive theory of transcending barriers was generated. Three stages in transcending barriers were identified: Addressing personal attributes, Understanding the 'bigger picture', and finally, 'Evaluating, planning and acting' to provide woman-centred care. An overview of these three stages provides the focus of this article. The theory of transcending barriers provides a new perspective on how newly-graduated midwives deal with applying the philosophy of midwifery in their first six months of practice. A number of implications for pre and post registration midwifery education and policy development are suggested, as well as recommendations for future research. Copyright © 2013 Elsevier Ltd. All rights reserved.

Development and testing of a mobile application to support diabetes self-management for people with newly diagnosed type 2 diabetes: a design thinking case study.

Science.gov (United States)

Petersen, Mira; Hempler, Nana F

2017-06-26

Numerous mobile applications have been developed to support diabetes-self-management. However, the majority of these applications lack a theoretical foundation and the involvement of people with diabetes during development. The aim of this study was to develop and test a mobile application (app) supporting diabetes self-management among people with newly diagnosed type 2 diabetes using design thinking. The app was developed and tested in 2015 using a design-based research approach involving target users (individuals newly diagnosed with type 2 diabetes), research scientists, healthcare professionals, designers, and app developers. The research approach comprised three major phases: inspiration, ideation, and implementation. The first phase included observations of diabetes education and 12 in-depth interviews with users regarding challenges and needs related to living with diabetes. The ideation phrase consisted of four interactive workshops with users focusing on app needs, in which ideas were developed and prioritized. Finally, 14 users tested the app over 4 weeks; they were interviewed about usability and perceptions about the app as a support tool. A multifunctional app was useful for people with newly diagnosed type 2 diabetes. The final app comprised five major functions: overview of diabetes activities after diagnosis, recording of health data, reflection games and goal setting, knowledge games and recording of psychological data such as sleep, fatigue, and well-being. Users found the app to be a valuable tool for support, particularly for raising their awareness about their psychological health and for informing and guiding them through the healthcare system after diagnosis. The design thinking processes used in the development and implementation of the mobile health app were crucial to creating value for users. More attention should be paid to the training of professionals who introduce health apps. Danish Data Protection Agency: 2012-58-0004. Registered 6

PCTFPeval: a web tool for benchmarking newly developed algorithms for predicting cooperative transcription factor pairs in yeast.

Science.gov (United States)

Lai, Fu-Jou; Chang, Hong-Tsun; Wu, Wei-Sheng

2015-01-01

Computational identification of cooperative transcription factor (TF) pairs helps understand the combinatorial regulation of gene expression in eukaryotic cells. Many advanced algorithms have been proposed to predict cooperative TF pairs in yeast. However, it is still difficult to conduct a comprehensive and objective performance comparison of different algorithms because of lacking sufficient performance indices and adequate overall performance scores. To solve this problem, in our previous study (published in BMC Systems Biology 2014), we adopted/proposed eight performance indices and designed two overall performance scores to compare the performance of 14 existing algorithms for predicting cooperative TF pairs in yeast. Most importantly, our performance comparison framework can be applied to comprehensively and objectively evaluate the performance of a newly developed algorithm. However, to use our framework, researchers have to put a lot of effort to construct it first. To save researchers time and effort, here we develop a web tool to implement our performance comparison framework, featuring fast data processing, a comprehensive performance comparison and an easy-to-use web interface. The developed tool is called PCTFPeval (Predicted Cooperative TF Pair evaluator), written in PHP and Python programming languages. The friendly web interface allows users to input a list of predicted cooperative TF pairs from their algorithm and select (i) the compared algorithms among the 15 existing algorithms, (ii) the performance indices among the eight existing indices, and (iii) the overall performance scores from two possible choices. The comprehensive performance comparison results are then generated in tens of seconds and shown as both bar charts and tables. The original comparison results of each compared algorithm and each selected performance index can be downloaded as text files for further analyses. Allowing users to select eight existing performance indices and 15

Planning for the Management and Disposition of Newly Generated TRU Waste from REDC

International Nuclear Information System (INIS)

Coffey, D. E.; Forrester, T. W.; Krause, T.

2002-01-01

This paper describes the waste characteristics of newly generated transuranic waste from the Radiochemical Engineering and Development Center at the Oak Ridge National Laboratory and the basic certification structure that will be proposed by the University of Tennessee-Battelle and Bechtel Jacobs Company LLC to the Waste Isolation Pilot Plant for this waste stream. The characterization approach uses information derived from the active production operations as acceptable knowledge for the Radiochemical Engineering and Development Center transuranic waste. The characterization approach includes smear data taken from processing and waste staging hot cells, as well as analytical data on product and liquid waste streams going to liquid waste disposal. Bechtel Jacobs Company and University of Tennessee-Battelle are currently developing the elements of a Waste Isolation Pilot Plant-compliant program with a plan to be certified by the Waste Isolation Pilot Plant for shipment of newly generated transuranic waste in the next few years. The current activities include developing interface plans, program documents, and waste stream specific procedures

Predictive score for the development or progression of Graves' orbitopathy in patients with newly diagnosed Graves' hyperthyroidism

DEFF Research Database (Denmark)

Wiersinga, Wilmar; Žarković, Miloš; Bartalena, Luigi

2018-01-01

OBJECTIVE: To construct a predictive score for the development or progression of Graves' orbitopathy (GO) in Graves' hyperthyroidism (GH). DESIGN: Prospective observational study in patients with newly diagnosed GH, treated with antithyroid drugs (ATD) for 18 months at ten participating centers f...

Pressure drop performance evaluation for test assemblies with the newly developed top and bottom nozzles

International Nuclear Information System (INIS)

Lee, S. K.; Park, N. K.; Su, J. M.; Kim, H. K.; Lee, J. N.; Kim, K. T.

2003-01-01

To perform the hydraulic test for the newly developed top and bottom nozzles, two kinds of test assemblies were manufactured i. e. one is the test assembly which has the newly developed top and bottom nozzles and the other is Guardian test assembly which is commercially in mass production now. The test results show that the test assembly with one top nozzle and two bottom nozzles has a greater pressure loss coefficient than Guardian test assembly by 60.9% and 90.4% at the bottom nozzle location. This cause is due to the debris filtering plate for bottom nozzle to improve a filtering efficiency aginst foreign material. In the region of mid grid and top nozzle, there is no difference in pressure loss coefficient between the test assemblies since the componet features in these regions are very similar or same each other. The loss coefficients are 14.2% and 21.9% for model A and B respectively in the scale of test assembly, and the value would be within the 10% in the scale of real fuel assembly. As a result of hydraulic performance evaluation, model A is superior to model B

How Schools Can Promote Healthy Development for Newly Arrived Immigrant and Refugee Adolescents: Research Priorities.

Science.gov (United States)

McNeely, Clea A; Morland, Lyn; Doty, S Benjamin; Meschke, Laurie L; Awad, Summer; Husain, Altaf; Nashwan, Ayat

2017-02-01

The US education system must find creative and effective ways to foster the healthy development of the approximately 2 million newly arrived immigrant and refugee adolescents, many of whom contend with language barriers, limited prior education, trauma, and discrimination. We identify research priorities for promoting the school success of these youth. The study used the 4-phase priority-setting method of the Child Health and Nutrition Research Initiative. In the final stage, 132 researchers, service providers, educators, and policymakers based in the United States were asked to rate the importance of 36 research options. The highest priority research options (range 1 to 5) were: evaluating newcomer programs (mean = 4.44, SD = 0.55), identifying how family and community stressors affect newly arrived immigrant and refugee adolescents' functioning in school (mean = 4.40, SD = 0.56), identifying teachers' major stressors in working with this population (mean = 4.36, SD = 0.72), and identifying how to engage immigrant and refugee families in their children's education (mean = 4.35, SD = 0.62). These research priorities emphasize the generation of practical knowledge that could translate to immediate, tangible benefits for schools. Funders, schools, and researchers can use these research priorities to guide research for the highest benefit of schools and the newly arrived immigrant and refugee adolescents they serve. © 2017, American School Health Association.

A multi-method approach to curriculum development for in-service training in China's newly established health emergency response offices.

Directory of Open Access Journals (Sweden)

Yadong Wang

Full Text Available To describe an innovative approach for developing and implementing an in-service curriculum in China for staff of the newly established health emergency response offices (HEROs, and that is generalisable to other settings.The multi-method training needs assessment included reviews of the competency domains needed to implement the International Health Regulations (2005 as well as China's policies and emergency regulations. The review, iterative interviews and workshops with experts in government, academia, the military, and with HERO staff were reviewed critically by an expert technical advisory panel.Over 1600 participants contributed to curriculum development. Of the 18 competency domains identified as essential for HERO staff, nine were developed into priority in-service training modules to be conducted over 2.5 weeks. Experts from academia and experienced practitioners prepared and delivered each module through lectures followed by interactive problem-solving exercises and desktop simulations to help trainees apply, experiment with, and consolidate newly acquired knowledge and skills.This study adds to the emerging literature on China's enduring efforts to strengthen its emergency response capabilities since the outbreak of SARS in 2003. The multi-method approach to curriculum development in partnership with senior policy-makers, researchers, and experienced practitioners can be applied in other settings to ensure training is responsive and customized to local needs, resources and priorities. Ongoing curriculum development should reflect international standards and be coupled with the development of appropriate performance support systems at the workplace for motivating staff to apply their newly acquired knowledge and skills effectively and creatively.

A multi-method approach to curriculum development for in-service training in China's newly established health emergency response offices.

Science.gov (United States)

Wang, Yadong; Li, Xiangrui; Yuan, Yiwen; Patel, Mahomed S

2014-01-01

To describe an innovative approach for developing and implementing an in-service curriculum in China for staff of the newly established health emergency response offices (HEROs), and that is generalisable to other settings. The multi-method training needs assessment included reviews of the competency domains needed to implement the International Health Regulations (2005) as well as China's policies and emergency regulations. The review, iterative interviews and workshops with experts in government, academia, the military, and with HERO staff were reviewed critically by an expert technical advisory panel. Over 1600 participants contributed to curriculum development. Of the 18 competency domains identified as essential for HERO staff, nine were developed into priority in-service training modules to be conducted over 2.5 weeks. Experts from academia and experienced practitioners prepared and delivered each module through lectures followed by interactive problem-solving exercises and desktop simulations to help trainees apply, experiment with, and consolidate newly acquired knowledge and skills. This study adds to the emerging literature on China's enduring efforts to strengthen its emergency response capabilities since the outbreak of SARS in 2003. The multi-method approach to curriculum development in partnership with senior policy-makers, researchers, and experienced practitioners can be applied in other settings to ensure training is responsive and customized to local needs, resources and priorities. Ongoing curriculum development should reflect international standards and be coupled with the development of appropriate performance support systems at the workplace for motivating staff to apply their newly acquired knowledge and skills effectively and creatively.

Physicochemical properties of newly developed bioactive glass cement and its effects on various cells.

Science.gov (United States)

Washio, Ayako; Nakagawa, Aika; Nishihara, Tatsuji; Maeda, Hidefumi; Kitamura, Chiaki

2015-02-01

Biomaterials used in dental treatments are expected to have favorable properties such as biocompatibility and an ability to induce tissue formation in dental pulp and periapical tissue, as well as sealing to block external stimuli. Bioactive glasses have been applied in bone engineering, but rarely applied in the field of dentistry. In the present study, bioactive glass cement for dental treatment was developed, and then its physicochemical properties and effects on cell responses were analyzed. To clarify the physicochemical attributes of the cement, field emission scanning electron microscopy, X-ray diffraction, and pH measurement were carried out. Cell attachment, morphology, and viability to the cement were also examined to clarify the effects of the cement on odontoblast-like cells (KN-3 cells), osteoblastic cells (MC3T3-E1 cells), human periodontal ligament stem/progenitor cells and neuro-differentiative cells (PC-12 cells). Hydroxyapatite-like precipitation was formed on the surface of the hardened cement and the pH level changed from pH10 to pH9, then stabilized in simulate body fluid. The cement had no cytotxic effects on these cells, and particulary induced process elongation of PC-12 cells. Our results suggest that the newly developed bioactive glass cement have capability of the application in dental procedures as bioactive cement. © 2014 Wiley Periodicals, Inc.

Association Between Manual Loading and Newly Developed Carpal Tunnel Syndrome in Subjects With Physical Disabilities: A Follow-Up Study.

Science.gov (United States)

Lin, Yen-Nung; Chiu, Chun-Chieh; Huang, Shih-Wei; Hsu, Wen-Yen; Liou, Tsan-Hon; Chen, Yi-Wen; Chang, Kwang-Hwa

2017-10-01

To identify the association between body composition and newly developed carpal tunnel syndrome (CTS) and to search for the best probabilistic cutoff value of associated factors to predict subjects with physical disabilities developing new CTS. Longitudinal. University-affiliated medical center. Subjects with physical disabilities (N=47; mean age ± SD, 42.1±7.7y). Not applicable. Median and ulnar sensory nerve conduction velocity (SNCV) were measured at the initial and follow-up tests (interval >2y). Total and regional body composition were measured with dual-energy x-ray absorptiometry at the initial test. Leg lean tissue percentage was calculated to delineate each participant's manual loading degree during locomotion. Leg lean tissue percentage is the lean tissue mass of both legs divided by body weight. Based on median SNCV changes, we divided all participants into 3 groups: subjects with bilateral CTS (median SNCV value normative ulnar SNCV value >37.8m/s) in the initial test (n=10), subjects with newly developed CTS in the follow-up test (n=8), and subjects without additional CTS in the follow-up test (n=27). Eight of 35 subjects not having bilateral CTS initially developed new CTS (8.8% per year; mean follow-up period, 2.6y). Leg lean tissue percentage was associated with the probability of newly developed CTS (adjusted odds ratio, .64; P12% were less likely to have developed new CTS at the follow-up test (sensitivity, .75; specificity, .85; area under the curve, .88; Pphysical disabilities. Therefore, a preventive program for those subjects at risk can start early. Copyright © 2017 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

NEWLY-PACKAGED BALI TOURIST PERFORMING ARTS IN THE PERSPECTIVE OF CULTURAL STUDIES

Directory of Open Access Journals (Sweden)

Ni Made Ruastiti

2012-11-01

Full Text Available This research is focused on the newly packaged tourist performing arts; they are anew concept and seem to be different from the general tourist performing arts. They arepackaged from various components of Balinese arts and managed as large scale-touristperforming arts in terms of materials, space, and time of their performances. The researchercalls them new types of Bali tourist performing arts because how they are presented isnew and different from the traditional tourist performing arts which are simply performed.In this research, the newly-packaged performing arts are analyzed in the perspective ofcultural studies.The research was carried out at three palaces in Bali; they are Mengwi Palace inBadung regency, Anyar Palace at Kerambitan, Tabanan regency, and Banyuning Palace atBongkasa, Badung regency. There are three main problems to be discussed: firstly, how dothe tourist performing arts emerge in all the palaces? Secondly, are they related to thetourist industry developed in the palaces?, thirdly, what is the impact and meaning of themfor the sake of the palaces, society, and Balinese culture? The researcher uses a qualitativemethod and an interdisciplinary approach as characteristics of cultural studies. The theoriesused are hegemony, deconstruction, and structuration.The result shows that the tourism development at all the palaces has made the localsociety become more critical. The money-oriented economy based on the spirit of gettingbenefit has made the emergence of comodification in all sectors of life. The emergence oftourist industry at the palaces has led to the idea of showing all of the useful art and culturalpotentials which at the palaces and their surroundings. Theoretically, the palaces can bestated to have deconstructed the concept of presenting the Bali tourist performing arts into anew one, that is, “the newly packaged Bali tourist performing arts”.It has been observed that all the palaces have developed t “Newly

The risk of newly developed visual impairment in treated normal-tension glaucoma: 10-year follow-up.

Science.gov (United States)

Choi, Yun Jeong; Kim, Martha; Park, Ki Ho; Kim, Dong Myung; Kim, Seok Hwan

2014-12-01

To investigate the risk and risk factors for newly developed visual impairment in treated patients with normal-tension glaucoma (NTG) followed up on for 10 years. Patients with NTG, who did not have visual impairment at the initial diagnosis and had undergone intraocular pressure (IOP)-lowering treatment for more than 7 years, were included on the basis of a retrospective chart review. Visual impairment was defined as either low vision (0.05 [20/400] ≤ visual acuity (VA) visual field (VF) visual impairment, Kaplan-Meier survival analysis and generalized linear mixed effects models were utilized. During the 10.8 years mean follow-up period, 20 eyes of 16 patients were diagnosed as visual impairment (12 eyes as low vision, 8 as blindness) among 623 eyes of 411 patients. The cumulative risk of visual impairment in at least one eye was 2.8% at 10 years and 8.7% at 15 years. The risk factors for visual impairment from treated NTG were worse VF mean deviation (MD) at diagnosis and longer follow-up period. The risk of newly developed visual impairment in the treated patients with NTG was relatively low. Worse VF MD at diagnosis and longer follow-up period were associated with development of visual impairment. © 2014 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

Value of a newly sequenced bacterial genome

DEFF Research Database (Denmark)

Barbosa, Eudes; Aburjaile, Flavia F; Ramos, Rommel Tj

2014-01-01

and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the "scientific value" of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses...... heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting...

Underground trials on a newly developed EDW 150-2 L unit

Energy Technology Data Exchange (ETDEWEB)

Wille, G.; Klimek, K.H.

1982-01-01

Coal-getting from medium thick coalbeds (> 1.7 m) requires high-performance shearer-loaders. Machine length and adjustability have to be such as to permit smooth cutting through geological faults. Furthermore they should be suitable to cut out niches for the AFC drives so that gateroads can be driven along with the face line. The newly developed EDW 150-2 L shearer-loader meets these expectations after various mechanical and electrical improvements. The unit proved its usefulness from the beginning and in the most difficult geological conditions where other shearer-loaders normally available for the range of coalbed thickness would mostly have failed. The multiple requirements and disturbances have led to a number of separate improvements and disturbances have led to a number of separate improvements which together contribute to a basic improvement of the machine concept as far as applications, operational flexibility and safety are concerned.

Preceptors' perceptions of the elements of a successful and an unsuccessful orientation period for newly graduated nurses.

Science.gov (United States)

Lindfors, Kirsi; Meretoja, Riitta; Kaunonen, Marja; Paavilainen, Eija

2018-04-01

To identify existing orientation patterns and to find elements that may enhance or impede successful orientation of newly graduated nurses. Preceptors have first-hand information concerning orientation and their opinions should not be forgotten when organisations develop their orientation processes. An open-ended questionnaire was undertaken to collect data from preceptors (n = 172) about the current orientation patterns. Data were analysed by using deductive content analysis and by quantifying the phrases. Communal commitment to the orientation process, strong professional orientation know-how and supportive leadership were the enhancing elements of successful orientation. Complex interpersonal relationship problems during orientation, inadequate orientation resources and the organisation's structural and functional problems were the impeding elements of successful orientation. With the elements of successful orientation we ensure a supportive transition to practice for newly graduate nurses and possibilities to focus on good orientation practices for preceptors. Nurse leaders play an important part in ensuring newly graduated nurses have a safe nursing career starting point and, for preceptors, opportunities to provide orientation that is as good as possible. Supportive leadership, sufficient resources and good interpersonal relationships should be the leading principles during newly graduated nurses' orientation period. © 2017 John Wiley & Sons Ltd.

A Newly Improved Modified Method Development and Validation of Bromofenac Sodium Sesquihydrate in Bulk Drug Manufacturing

OpenAIRE

Sunil Kumar Yelamanchi V; Useni Reddy Mallu; I. V Kasi Viswanath; D. Balasubramanyam; G. Narshima Murthy

2016-01-01

The main objective of this study was to develop a simple, efficient, specific, precise and accurate newly improved modified Reverse Phase High Performance Liquid Chromatographic Purity (or) Related substance method for bromofenac sodium sesquihydrate active pharmaceuticals ingredient dosage form. Validation of analytical method is the confirmation by examination and the provision of objective evidence that the particular requirements for a specific intended use are fulfilled as per ICH, USP...

Engineering fluorescent proteins towards ultimate performances: lessons from the newly developed cyan variants

International Nuclear Information System (INIS)

Mérola, Fabienne; Erard, Marie; Fredj, Asma; Pasquier, Hélène

2016-01-01

New fluorescent proteins (FPs) are constantly discovered from natural sources, and submitted to intensive engineering based on random mutagenesis and directed evolution. However, most of these newly developed FPs fail to achieve all the performances required for their bioimaging applications. The design of highly optimised FP-based reporters, simultaneously displaying appropriate colour, multimeric state, chromophore maturation, brightness, photostability and environmental sensitivity will require a better understanding of the structural and dynamic determinants of FP photophysics. The recent development of cyan fluorescent proteins (CFPs) like mCerulean3, mTurquoise2 and Aquamarine brings a different view on these questions, as in this particular case, a step by step evaluation of critical mutations has been performed within a family of spectrally identical and evolutionary close variants. These efforts have led to CFPs with quantum yields close to unity, near single exponential emission decays, high photostability and complete insensitivity to pH, making them ideal choices as energy transfer donors in FRET and FLIM imaging applications. During this process, it was found that a proper amino-acid choice at only two positions (148 and 65) is sufficient to transform the performances of CFPs: with the help of structural and theoretical investigations, we rationalise here how these two positions critically control the CFP photophysics, in the context of FPs derived from the Aequorea victoria species. Today, these results provide a useful toolbox for upgrading the different CFP donors carried by FRET biosensors. They also trace the route towards the de novo design of FP-based optogenetic devices that will be perfectly tailored to dedicated imaging and sensing applications. (topical review)

Enhancement of Treatment Efficiency of Recalcitrant Wastewater Containing Textile Dyes Using a Newly Developed Iron Zeolite Socony Mobil-5 Heterogeneous Catalyst

Science.gov (United States)

Ahmad, Mushtaq; Asghar, Anam; Abdul Raman, Abdul Aziz; Wan Daud, Wan Mohd Ashri

2015-01-01

Fenton oxidation, an advanced oxidation process, is an efficient method for the treatment of recalcitrant wastewaters. Unfortunately, it utilizes H2O2 and iron-based homogeneous catalysts, which lead to the formation of high volumes of sludge and secondary pollutants. To overcome these problems, an alternate option is the usage of heterogeneous catalyst. In this study, a heterogeneous catalyst was developed to provide an alternative solution for homogeneous Fenton oxidation. Iron Zeolite Socony Mobile-5 (Fe-ZSM-5) was synthesized using a new two-step process. Next, the catalyst was characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy, fourier transform infrared spectroscopy, and Brunauer-Emmett-Teller analysis and tested against a model wastewater containing the azo dye Acid Blue 113. Results showed that the loading of iron particles reduced the surface area of the catalyst from 293.59 to 243.93 m2/g; meanwhile, the average particle size of the loaded material was 12.29 nm. Furthermore, efficiency of the developed catalyst was evaluated by performing heterogeneous Fenton oxidation. Taguchi method was coupled with principal component analysis in order to assess and optimize mineralization efficiency. Experimental results showed that under optimized conditions, over 99.7% degradation and 77% mineralization was obtained, with a 90% reduction in the consumption of the developed catalyst. Furthermore, the developed catalyst was stable and reusable, with less than 2% leaching observed under optimized conditions. Thus, the present study proved that newly developed catalyst has enhanced the oxidation process and reduced the chemicals consumption. PMID:26517827

Enhancement of Treatment Efficiency of Recalcitrant Wastewater Containing Textile Dyes Using a Newly Developed Iron Zeolite Socony Mobil-5 Heterogeneous Catalyst.

Science.gov (United States)

Ahmad, Mushtaq; Asghar, Anam; Abdul Raman, Abdul Aziz; Wan Daud, Wan Mohd Ashri

2015-01-01

Fenton oxidation, an advanced oxidation process, is an efficient method for the treatment of recalcitrant wastewaters. Unfortunately, it utilizes H2O2 and iron-based homogeneous catalysts, which lead to the formation of high volumes of sludge and secondary pollutants. To overcome these problems, an alternate option is the usage of heterogeneous catalyst. In this study, a heterogeneous catalyst was developed to provide an alternative solution for homogeneous Fenton oxidation. Iron Zeolite Socony Mobile-5 (Fe-ZSM-5) was synthesized using a new two-step process. Next, the catalyst was characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy, fourier transform infrared spectroscopy, and Brunauer-Emmett-Teller analysis and tested against a model wastewater containing the azo dye Acid Blue 113. Results showed that the loading of iron particles reduced the surface area of the catalyst from 293.59 to 243.93 m2/g; meanwhile, the average particle size of the loaded material was 12.29 nm. Furthermore, efficiency of the developed catalyst was evaluated by performing heterogeneous Fenton oxidation. Taguchi method was coupled with principal component analysis in order to assess and optimize mineralization efficiency. Experimental results showed that under optimized conditions, over 99.7% degradation and 77% mineralization was obtained, with a 90% reduction in the consumption of the developed catalyst. Furthermore, the developed catalyst was stable and reusable, with less than 2% leaching observed under optimized conditions. Thus, the present study proved that newly developed catalyst has enhanced the oxidation process and reduced the chemicals consumption.

Development of a novel cold forging process to manufacture eccentric shafts

Science.gov (United States)

Pasler, Lukas; Liewald, Mathias

2018-05-01

Since the commercial usage of compact combustion engines, eccentric shafts have been used to transform translational into rotational motion. Over the years, several processes to manufacture these eccentric shafts or crankshafts have been developed. Especially for single-cylinder engines manufactured in small quantities, built crankshafts disclose advantages regarding tooling costs and performance. Those manufacturing processes do have one thing in common: They are all executed at elevated temperatures to enable the material to be formed to high forming degree. In this paper, a newly developed cold forging process is presented, which combines lateral extrusion and shifting for manufacturing a crank in one forming operation at room temperature. In comparison to the established upsetting and shifting methods to manufacture such components, the tool cavity or crank web thickness remains constant. Therefore, the developed new process presented in this paper consists of a combination of shifting and extrusion of the billet, which allows pushing material into the forming zone during shifting. In order to reduce the tensile stresses induced by the shifting process, compressive stresses are superimposed. It is expected that the process limits will be expanded regarding the horizontal displacement and form filling. In the following report, the simulation and design of the tooling concept are presented. Experiments were conducted and compared with corresponding simulation results afterwards.

Microstructural development during the quenching and partitioning process in a newly designed low-carbon steel

Energy Technology Data Exchange (ETDEWEB)

Santofimia, M.J., E-mail: m.j.santofimianavarro@tudelft.nl [Materials Innovation Institute (M2i), Mekelweg 2, 2628 CD Delft (Netherlands); Department of Materials Science and Engineering, Delft University of Technology, Mekelweg 2, 2628 CD Delft (Netherlands); Zhao, L. [Materials Innovation Institute (M2i), Mekelweg 2, 2628 CD Delft (Netherlands); Department of Materials Science and Engineering, Delft University of Technology, Mekelweg 2, 2628 CD Delft (Netherlands); Petrov, R. [Department of Metallurgy and Materials Science, Ghent University, Technologiepark 903, 9052 Ghent (Belgium); Department of Materials Science and Engineering, Delft University of Technology, Mekelweg 2, 2628 CD Delft (Netherlands); Kwakernaak, C.; Sloof, W.G.; Sietsma, J. [Department of Materials Science and Engineering, Delft University of Technology, Mekelweg 2, 2628 CD Delft (Netherlands)

2011-09-15

This paper presents a detailed characterization of the microstructural development of a new quenching and partitioning (Q and P) steel. Q and P treatments, starting from full austenitization, were applied to the developed steel, leading to microstructures containing volume fractions of retained austenite of up to 0.15. The austenite was distributed as films in between the martensite laths. Analysis demonstrates that, in this material, stabilization of austenite can be achieved at significantly shorter time scales via the Q and P route than is possible via a bainitic isothermal holding. The results showed that the thermal stabilization of austenite during the partitioning step is not necessarily accompanied by a significant expansion of the material. This implies that the process of carbon partitioning from martensite to austenite occurs across low-mobility martensite-austenite interfaces. The amount of martensite formed during the first quench has been quantified. Unlike martensite formed in the final quench, this martensite was found to be tempered during partitioning. Measured volume fractions of retained austenite after different treatments were compared with simulations using model descriptions for carbon partitioning from martensite to austenite. Simulation results confirmed that the carbon partitioning takes place at low-mobility martensite-austenite interfaces.

The nitrate to ammonia and ceramic (NAC) process: A newly developed low-temperature technology

International Nuclear Information System (INIS)

Mattus, A.J.; Lee, D.D.

1993-01-01

Bench-top feasibility studies with Hanford single-shell tank (SST) simulants, using a new low-temperature (50-60 degrees C) process for converting nitrate to ammonia and ceramic, have conclusively shown that between 90 and 99% of the nitrate at Hanford can be readily converted to ammonia. In this process, aluminum powders or shot can be used to convert alkaline, nitrate-based supernate to ammonia and an alumina-silica-based ceramic solid. The process may actually be able to utilize already contaminated aluminum scrap metal from various US DOE sites to effect the conversion. The final nitrate-free ceramic product can be calcined, pressed, and sintered like any other ceramic. Based upon the starting volumes of 6.2 and 3.1 M sodium nitrate solution (probable supernate concentrations resulting from salt-cake/sludge removal from the Hanford SSTs), volume reductions as high as 70% are currently obtained, compared with an expected 40 to 50% volume increase if the Hanford supernate were grouted. Engineering data extracted from bench-top studies indicate that the process will be very economical. These data were used to cost a batch facility with a production rate of 1200 kilograms of nitrate per hour for processing all the Hanford SST waste over 20 years. Our process cost analysis indicates that between $2.01 and 2.66 will be required to convert each kilogram of nitrate. Based upon 1957 literature, these costs are one-third to one-half of the processing costs quoted for electrolytic and thermal processes

A Newly Developed Nested PCR Assay for the Detection of Helicobacter pylori in the Oral Cavity.

Science.gov (United States)

Ismail, Hawazen; Morgan, Claire; Griffiths, Paul; Williams, John; Jenkins, Gareth

2016-01-01

To develop a new nested polymerase chain reaction (PCR) assay for identifying Helicobacter pylori DNA from dental plaque. H. pylori is one of the most common chronic bacterial pathogens in humans. The accurate detection of this organism is essential for proper patient management and for the eradication of the bacteria following treatment. Forty-nine patients (24 males and 25 females; mean age: 51; range, 19 to 94 y) were investigated for the presence of H. pylori in dental plaque by single-step PCR and nested PCR and in the stomach by single-step PCR, nested PCR, and histologic examination. The newly developed nested PCR assay identified H. pylori DNA in gastric biopsies of 18 patients who were histologically classified as H. pylori-positive and 2 additional biopsies of patients who were H. pylori-negative by histologic examination (20/49; 40.8%). Dental plaque samples collected before and after endoscopy from the 49 patients revealed that single-step PCR did not detect H. pylori but nested PCR was able to detect H. pylori DNA in 40.8% (20/49) patients. Nested PCR gave a higher detection rate (40.8%, 20/49) than that of histology (36.7%, 18/49) and single-step PCR. When nested PCR results were compared with histology results there was no significant difference between the 2 methods. Our newly developed nested PCR assay is at least as sensitive as histology and may be useful for H. pylori detection in patients unfit for endoscopic examination.

Characteristics of bread prepared from wheat flours blended with various kinds of newly developed rice flours.

Science.gov (United States)

Nakamura, S; Suzuki, K; Ohtsubo, K

2009-04-01

Characteristics of the bread prepared from wheat flour blended with the flour of various kinds of newly developed rice cultivars were investigated. Qualities of the bread made from wheat flour blended with rice flour have been reported to be inferior to those from 100% wheat flour bread. To improve its qualities, we searched for the new-characteristic rice flours among the various kinds of newly developed rice cultivars to blend with the wheat flour for the bread preparation. The most suitable new characteristic rices are combination of purple waxy rice, high-amylose rice, and sugary rice. Specific volume of the bread from the combination of wheat and these 3 kinds of rice flours showed higher specific volume (3.93) compared with the traditional wheat/rice bread (3.58). We adopted the novel method, continuous progressive compression test, to measure the physical properties of the dough and the bread in addition to the sensory evaluation. As a result of the selection of the most suitable rice cultivars and blending ratio with the wheat flour, we could develop the novel wheat/rice bread, of which loaf volume, physical properties, and tastes are acceptable and resistant to firming on even 4 d after the bread preparation. To increase the ratio of rice to wheat, we tried to add a part of rice as cooked rice grains. The specific volume and qualities of the bread were maintained well although the rice content of total flour increased from 30% to 40%.

The Development and Numerical Analysis of the Conical Radiator Extrusion Process

Directory of Open Access Journals (Sweden)

Michalczyk J.

2017-12-01

Full Text Available The article presents a newly developed method for single-operation extrusion of conical radiators. This is the author’s radiator manufacturing method being the subject of a patent application. The proposed method enables the manufacture of radiators either with or without an inner opening and with an integral plate. Selected results of numerical computations made within Forge®3D, a finite element method (FEM-based software program, were presented during the analysis of the process. A comparative analysis of the proposed manufacturing method using the double-sided extrusion method was also made.

Idaho Nuclear Technology and Engineering Center Newly Generated Liquid Waste Demonstration Project Feasibility Study

International Nuclear Information System (INIS)

Herbst, A.K.

2000-01-01

A research, development, and demonstration project for the grouting of newly generated liquid waste (NGLW) at the Idaho Nuclear Technology and Engineering Center is considered feasible. NGLW is expected from process equipment waste, decontamination waste, analytical laboratory waste, fuel storage basin waste water, and high-level liquid waste evaporator condensate. The potential grouted waste would be classed as mixed low-level waste, stabilized and immobilized to meet RCRA LDR disposal in a grouting process in the CPP-604 facility, and then transported to the state

Establishment probability in newly founded populations

Directory of Open Access Journals (Sweden)

Gusset Markus

2012-06-01

Full Text Available Abstract Background Establishment success in newly founded populations relies on reaching the established phase, which is defined by characteristic fluctuations of the population’s state variables. Stochastic population models can be used to quantify the establishment probability of newly founded populations; however, so far no simple but robust method for doing so existed. To determine a critical initial number of individuals that need to be released to reach the established phase, we used a novel application of the “Wissel plot”, where –ln(1 – P0(t is plotted against time t. This plot is based on the equation P0t=1–c1e–ω1t, which relates the probability of extinction by time t, P0(t, to two constants: c1 describes the probability of a newly founded population to reach the established phase, whereas ω1 describes the population’s probability of extinction per short time interval once established. Results For illustration, we applied the method to a previously developed stochastic population model of the endangered African wild dog (Lycaon pictus. A newly founded population reaches the established phase if the intercept of the (extrapolated linear parts of the “Wissel plot” with the y-axis, which is –ln(c1, is negative. For wild dogs in our model, this is the case if a critical initial number of four packs, consisting of eight individuals each, are released. Conclusions The method we present to quantify the establishment probability of newly founded populations is generic and inferences thus are transferable to other systems across the field of conservation biology. In contrast to other methods, our approach disaggregates the components of a population’s viability by distinguishing establishment from persistence.

Progress of fusion fuel processing system development at the Japan Atomic Energy Research Institute

International Nuclear Information System (INIS)

Nishi, Masataka; Yamanishi, Toshihiko; Kawamura, Yoshinori; Iwai, Yasunori; Isobe, Kanetsugu; O'Hira, Shigeru; Hayashi, Takumi; Nakamura, Hirofumi; Kobayashi, Kazuhiro; Suzuki, Takumi; Yamada, Masayuki; Konishi, Satoshi

2000-01-01

The Tritium Process Laboratory (TPL) at the Japan Atomic Energy Research Institute has been working on the development of fuel processing technology for fusion reactors as a major activity. A fusion fuel processing loop was installed and is being tested with tritium under reactor relevant conditions. The loop at the TPL consists of ZrCo based tritium storage beds, a plasma exhaust processing system using a palladium diffuser and an electrolytic reactor, cryogenic distillation columns for isotope separation, and analytical systems based on newly developed micro gas chromatographs and Raman Spectroscopy. Several extended demonstration campaigns were performed under realistic reactor conditions to test tritiated impurity processing. A sophisticated control technique of distillation column was performed at the same time, and integrated fuel circulation was successfully demonstrated. Major recent design work on the International Thermonuclear Experimental Reactor (ITER) tritium plant at the TPL is devoted to water detritiation based on liquid phase catalytic exchange for improved tritium removal from waste water

Materials and process engineering projects for the Sandia National Laboratories/Newly Independent States Industrial Partnering Program. Volume 1

Energy Technology Data Exchange (ETDEWEB)

Zanner, F.J.; Moffatt, W.C.

1995-07-01

In July, 1994, a team of materials specialists from Sandia and U S Industry traveled to Russia and the Ukraine to select and fund projects in materials and process technology in support of the Newly Independent States/Industrial Partnering Program (NIS/IPP). All of the projects are collaborations with scientists and Engineers at NIS Institutes. Each project is scheduled to last one year, and the deliverables are formatted to supply US Industry with information which will enable rational decisions to be made regarding the commercial value of these technologies. This work is an unedited interim compilation of the deliverables received to date.

Materials and process engineering projects for the Sandia National Laboratories/Newly Independent States Industrial Partnering Program. Volume 2

International Nuclear Information System (INIS)

Zanner, F.J.; Moffatt, W.C.

1995-07-01

In July, 1994, a team of materials specialists from Sandia and US. Industry traveled to Russia and the Ukraine to select and fund projects in materials and process technology in support of the Newly Independent States/Industrial Partnering Program (NIS/IPP). All of the projects are collaborations with scientists and Engineers at NIS Institutes. Each project is scheduled to last one year, and the deliverables are formatted to supply US. Industry with information which will enable rational decisions to be made regarding the commercial value of these technologies. This work is an unedited interim compilation of the deliverables received to date

Materials and process engineering projects for the Sandia National Laboratories/Newly Independent States Industrial Partnering Program. Volume 2

Energy Technology Data Exchange (ETDEWEB)

Zanner, F.J.; Moffatt, W.C.

1995-07-01

In July, 1994, a team of materials specialists from Sandia and US. Industry traveled to Russia and the Ukraine to select and fund projects in materials and process technology in support of the Newly Independent States/Industrial Partnering Program (NIS/IPP). All of the projects are collaborations with scientists and Engineers at NIS Institutes. Each project is scheduled to last one year, and the deliverables are formatted to supply US. Industry with information which will enable rational decisions to be made regarding the commercial value of these technologies. This work is an unedited interim compilation of the deliverables received to date.

Americium-curium vitrification process development

International Nuclear Information System (INIS)

Fellinger, A.P.; Baich, M.A.; Hardy, B.J

1999-01-01

The successful demonstration of sequentially drying, calcining and vitrifying an oxalate slurry in the Drain Tube Test Stand (DTTS) vessel provided the process basis for testing on a larger scale in a cylindrical induction heated melter. A single processing issue, that of batch volume expansion, was encountered during the initial stage of testing. The increase in batch volume centered on a sintered frit cap and high temperature bubble formation. The formation of a sintered frit cap expansion was eliminated with the use of cullet. Volume expansions due to high temperature bubble formation (oxygen liberation from cerium reduction) were mitigated in the DTTS melter vessel through a vessel temperature profile that effectively separated the softening point of the glass cullet and the evolving oxygen from cerium reduction. An increased processing temperature of 1,470 C and a two hour hold time to find any remaining bubbles successfully reduced bubbles in the poured glass to an acceptable level. The success of the preliminary process demonstrations provided a workable process basis that was directly applicable to the newly installed Cylindrical Induction Melter (CIM) system, making the batch flowsheet the preferred option for vitrification of the americium-curium surrogate feed stream

The effectiveness of newly developed written asthma action plan in improvement of asthma outcome in children.

Science.gov (United States)

Lakupoch, Kingthong; Manuyakorn, Wiparat; Preutthipan, Aroonwan; Kamalaporn, Harutai

2017-09-17

Providing asthma education about controller medication use and appropriate management of asthma exacerbation are the keys to improving the disease outcome. Many asthma guidelines recommend that physicians provide written asthma action plan (WAAP) to all of their asthmatic patients. However, the benefit of WAAP is unclear. Thus, we have created a new WAAP which is simplified in Thai and more user friendly. To determine the effectiveness of the newly developed asthma action plan in management of children with asthma. Asthmatic children who meet inclusion criteria all received the WAAP and they were followed up for 6 months with measurement of outcome variables, such as asthma exacerbation that required emergency room visit, unscheduled OPD visit, admission and school absence in order to compare with the past 6 months before receiving the WAAP. The analyzed outcomes of forty-nine children show significantly reduced emergency room visit (P-value 0.005), unscheduled OPD visit (P-value 0.046), admission days (P-value 0.026) and school absence days (P-value 0.022). Well controlled group and mild severity group were not the factors that contribute to decreased emergency room visit but step up therapy may be the co-factor to decreased ER visit. The results of this study suggest that the provision of newly developed WAAP is useful for improving self-care of asthma patients and reducing asthma exacerbation.

Development and Application of SKSSIM Simulation Software for the Oxygen Bottom Blown Copper Smelting Process

Directory of Open Access Journals (Sweden)

Qinmeng Wang

2017-10-01

Full Text Available The oxygen bottom blown copper smelting process (SKS process is a newly developed intense smelting process, which has been widely applied to copper production in China. A multiphase equilibrium model for the SKS process was established based on its mechanism characteristics and the principle of Gibbs energy minimization, and an efficient simulation software—SKSSIM (SKS Simulation—was developed based on the model. Industrial data from the SKS process were used to compare with the calculated data from the SKSSIM software. The calculated data on the compositions of slag and matte as well as the distribution ratios of minor elements (such as Pb, Zn, As, Sb and Bi among the slags, mattes and off-gases were in good agreement with the actual plant data. Accordingly, the SKSSIM simulation software has the potentail to be used for the prediction of smelting production and for optimizing the operating parameters of the SKS process.

Newly blind persons using virtual environment system in a traditional orientation and mobility rehabilitation program: a case study.

Science.gov (United States)

Lahav, Orly; Schloerb, David W; Srinivasan, Mandayam A

2012-09-01

This paper presents a virtual reality system (the BlindAid) developed for orientation and mobility training of people who are newly blind. The BlindAid allows users to interact with different virtual structures and objects via auditory and haptic feedback. This case study aims to examine if and how the BlindAid, in conjunction with a traditional rehabilitation programme, can help people who are newly blind develop new orientation and mobility methods. Follow-up research based on this study, with a large experiment and control group, could contribute to the area of orientation and mobility rehabilitation training for the newly blind. The case study research focused on A., a woman who is newly blind, for 17 virtual sessions spanning ten weeks, during the 12 weeks of her traditional orientation and mobility rehabilitation programme. The research was implemented by using virtual environment (VE) exploration and orientation tasks in VE and physical spaces. The research methodology used both qualitative and quantitative methods, including interviews, questionnaire, videotape recording, and user computer logs. The results of this study helped elucidate several issues concerning the contribution of the BlindAid system to the exploration strategies and learning processes experienced by the participant in her encounters with familiar and unfamiliar physical surroundings. [Box: see text].

Study on mid and long-term strategic plan formulation for newly-constructed NPP

International Nuclear Information System (INIS)

Song Lin

2014-01-01

Mid and Long-term strategic plan plays a key role for the management of a newly constructed nuclear power company. Among others, process, goals, and risk management, are the primary concerns during plan preparing. The article analyzed these three areas for Fuqing NPP, including the formulating process for the plan, the mid and long-term goal setting of the company, the major risk analysis and countermeasure selection therefore. Through that solutions and suggestions for strategic plan formulation were concluded for newly-constructed NPP. (author)

Conventional and improved cytotoxicity test methods of newly developed biodegradable magnesium alloys

Science.gov (United States)

Han, Hyung-Seop; Kim, Hee-Kyoung; Kim, Yu-Chan; Seok, Hyun-Kwang; Kim, Young-Yul

2015-11-01

Unique biodegradable property of magnesium has spawned countless studies to develop ideal biodegradable orthopedic implant materials in the last decade. However, due to the rapid pH change and extensive amount of hydrogen gas generated during biocorrosion, it is extremely difficult to determine the accurate cytotoxicity of newly developed magnesium alloys using the existing methods. Herein, we report a new method to accurately determine the cytotoxicity of magnesium alloys with varying corrosion rate while taking in-vivo condition into the consideration. For conventional method, extract quantities of each metal ion were determined using ICP-MS and the result showed that the cytotoxicity due to pH change caused by corrosion affected the cell viability rather than the intrinsic cytotoxicity of magnesium alloy. In physiological environment, pH is regulated and adjusted within normal pH (˜7.4) range by homeostasis. Two new methods using pH buffered extracts were proposed and performed to show that environmental buffering effect of pH, dilution of the extract, and the regulation of eluate surface area must be taken into consideration for accurate cytotoxicity measurement of biodegradable magnesium alloys.

Newly patented process enables low-cost solution for increasing white light spectrum of LEDs

Science.gov (United States)

Spanard, Jan-Marie

2017-10-01

A newly patented process for completing the spectral light array emitted by LED bulbs provides a low-cost method for producing better human centered lighting (HCL). This process uses non-luminescent colorant filters, filling out the jagged LED spectral emission into a full, white light array. While LED bulbs have the distinct economic advantages of using less energy, producing less heat and lasting years longer than traditional incandescent bulbs, the persistent metameric failure of LED bulbs has resulted in slower, and sometimes reluctant, adoption of LED lighting by the residential, retail and architectural markets. Adding missing wavelengths to LED generated bulbs via colorant filters increases the aesthetic appeal of the light by decreasing current levels of metameric failure, reducing the `flatness', `harshness', and `dullness' of LED generated light reported by consumers. LED phosphor-converted light can be successfully tuned to "whiter" white light with selective color filtering using permanent, durable transparent pigments. These transparent pigments are selectively applied in combination with existing manufacturing technologies and utilized as a final color-tuning step in bulb design. The quantity of emitted light chosen for color filtering can be adjusted from 1% to 100% of emitted light, creating a custom balance of light quantity with light quality. This invention recognizes that "better light" is frequently chosen over "more light" in the consumer marketplace.

Laboratory model study of newly deposited dredger fills using improved multiple-vacuum preloading technique

Directory of Open Access Journals (Sweden)

Jingjin Liu

2017-10-01

Full Text Available Problems continue to be encountered concerning the traditional vacuum preloading method in field during the treatment of newly deposited dredger fills. In this paper, an improved multiple-vacuum preloading method was developed to consolidate newly dredger fills that are hydraulically placed in seawater for land reclamation in Lingang Industrial Zone of Tianjin City, China. With this multiple-vacuum preloading method, the newly deposited dredger fills could be treated effectively by adopting a novel moisture separator and a rapid improvement technique without sand cushion. A series of model tests was conducted in the laboratory for comparing the results from the multiple-vacuum preloading method and the traditional one. Ten piezometers and settlement plates were installed to measure the variations in excess pore water pressures and moisture content, and vane shear strength was measured at different positions. The testing results indicate that water discharge–time curves obtained by the traditional vacuum preloading method can be divided into three phases: rapid growth phase, slow growth phase, and steady phase. According to the process of fluid flow concentrated along tiny ripples and building of larger channels inside soils during the whole vacuum loading process, the fluctuations of pore water pressure during each loading step are divided into three phases: steady phase, rapid dissipation phase, and slow dissipation phase. An optimal loading pattern which could have a best treatment effect was proposed for calculating the water discharge and pore water pressure of soil using the improved multiple-vacuum preloading method. For the newly deposited dredger fills at Lingang Industrial Zone of Tianjin City, the best loading step was 20 kPa and the loading of 40–50 kPa produced the highest drainage consolidation. The measured moisture content and vane shear strength were discussed in terms of the effect of reinforcement, both of which indicate

Evaluation of Shielding Performance for Newly Developed Composite Materials

Science.gov (United States)

Evans, Beren Richard

This work details an investigation into the contributing factors behind the success of newly developed composite neutron shield materials. Monte Carlo simulation methods were utilized to assess the neutron shielding capabilities and secondary radiation production characteristics of aluminum boron carbide, tungsten boron carbide, bismuth borosilicate glass, and Metathene within various neutron energy spectra. Shielding performance and secondary radiation data suggested that tungsten boron carbide was the most effective composite material. An analysis of the macroscopic cross-section contributions from constituent materials and interaction mechanisms was then performed in an attempt to determine the reasons for tungsten boron carbide's success over the other investigated materials. This analysis determined that there was a positive correlation between a non-elastic interaction contribution towards a material's total cross-section and shielding performance within the thermal and epi-thermal energy regimes. This finding was assumed to be a result of the boron-10 absorption reaction. The analysis also determined that within the faster energy regions, materials featuring higher non-elastic interaction contributions were comparable to those exhibiting primarily elastic scattering via low Z elements. This allowed for the conclusion that composite shield success within higher energy neutron spectra does not necessitate the use elastic scattering via low Z elements. These findings suggest that the inclusion of materials featuring high thermal absorption properties is more critical to composite neutron shield performance than the presence of constituent materials more inclined to maximize elastic scattering energy loss.

Combustion, performance and emissions characteristics of a newly ...

Indian Academy of Sciences (India)

of a newly developed CRDI single cylinder diesel engine. AVINASH ... In case of unit injector and unit pump systems, fuel injection pressure depends on ... nozzle hole diameters were effective in reducing smoke and PM emissions. However ...

Development of laboratory and process sensors to monitor particle size distribution of industrial slurries

Energy Technology Data Exchange (ETDEWEB)

Pendse, H.P.

1992-10-01

In this paper we present a novel measurement technique for monitoring particle size distributions of industrial colloidal slurries based on ultrasonic spectroscopy and mathematical deconvolution. An on-line sensor prototype has been developed and tested extensively in laboratory and production settings using mineral pigment slurries. Evaluation to date shows that the sensor is capable of providing particle size distributions, without any assumptions regarding their functional form, over diameters ranging from 0.1 to 100 micrometers in slurries with particle concentrations of 10 to 50 volume percents. The newly developed on-line sensor allows one to obtain particle size distributions of commonly encountered inorganic pigment slurries under industrial processing conditions without dilution.

The use of newly developed real-time PCR for the rapid identification of bacteria in culture-negative osteomyelitis.

Science.gov (United States)

Kobayashi, Naomi; Bauer, Thomas W; Sakai, Hiroshige; Togawa, Daisuke; Lieberman, Isador H; Fujishiro, Takaaki; Procop, Gary W

2006-12-01

We report a case of a culture-negative osteomyelitis in which our newly developed real-time polymerase chain reaction (PCR) could differentiate Staphylococcus aureus from Staphylococcus epidermidis. This is the first report that described the application of this novel assay to an orthopedics clinical sample. This assay may be useful for other clinical culture-negative cases in a combination with a broad-spectrum assay as a rapid microorganism identification method.

Developing and enforcing internal information systems standards: InduMaker’s Standards Management Process

Directory of Open Access Journals (Sweden)

Claudia Loebbecke

2016-01-01

Full Text Available It is widely agreed that standards provide numerous benefits when available and enforced. Company-internal Information Systems (IS management procedures and solutions, in the following coined IS ‘standards’, allow for harmonizing operations between company units, locations and even different service providers. However, many companies lack an organized process for defining and managing internal IS standards, which causes uncertainties and delays in decision making, planning, and design processes. In this case study of the globally operating InduMaker (anonymized company name, an established manufacturing supplier, we look into the company-internal management of IS standards. Theoretically grounded in the organizational and IS-focused literature on business process modelling and business process commoditization, we describe and investigate InduMaker’s newly developed Standard Management Process (SMP for defining and managing company-internal business and IS standards, with which the multinational pursues offering clear answers to business and IT departments about existing IS standards, their degree of obligation, applicability, and scope at any time.

Perceptions of the clinical competence of newly registered nurses in the North West province

Directory of Open Access Journals (Sweden)

M.R. Moeti

2004-09-01

Full Text Available The clinical competence of newly registered nurses relating to the care of individual Clients, depends on their ability to correlate theoretical knowledge learned in the classroom with practice and the development of clinical skills. Its foundation lies in the ability to identify and solve problems that emanate from critical thinking, analytical reasoning and reflective practice. It is clear that the quality of clinical exposure plays a leading role in the development of nursing professionals. Nursing skills alone cannot ensure quality care of clients without the application of theory. Facilitation of this theory to practice therefore remains an essential component of nursing education. This study was aimed at identifying areas of incompetence of newly registered nurses (1998- 2001 in the clinical area by determining the newly registered nurses1 and professional nurses1 perceptions of the competence of the newly registered nurses. A quantitative, non-experimental, descriptive survey was used to collect the data regarding the clinical competence of newly registered nurses (1998-2001.

Measurement equivalence of the newly developed Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55).

Science.gov (United States)

Ferro, Mark A; Goodwin, Shane W; Sabaz, Mark; Speechley, Kathy N

2016-03-01

The aim of this study was to examine measurement equivalence of the newly developed Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55) across age, sex, and time in a representative sample of children with newly diagnosed epilepsy. Data come from 373 children enrolled in the Health-related Quality of Life in Children with Epilepsy Study (HERQULES), a multisite prospective cohort study. Measurement equivalence was examined using a multiple-group confirmatory factor analysis framework, whereby increasingly stringent parameter constraints are imposed on the model. Comparison groups were stratified based on age (4-7 years vs. 8-12 years), sex (male vs. female), and time (measurement of health-related quality of life at diagnosis vs. 24 months later). The QOLCE-55 demonstrated measurement equivalence at the level of strict invariance for each model tested--age: χ(2) (3,123) = 4,097.3, p QOLCE-55 are perceived similarly among groups stratified by age, sex, and time and provide further evidence supporting the validity of the scale in children with epilepsy. Health professionals and researchers should be confident that group comparisons made using the QOLCE-55 are unbiased and that any group differences detected are meaningful; that is, not related to differences in the interpretation of items by informants. Future research replicating these findings is encouraged. Wiley Periodicals, Inc. © 2016 International League Against Epilepsy.

Practicing on Newly Dead

Directory of Open Access Journals (Sweden)

Jewel Abraham

2015-07-01

Full Text Available A newly dead cadaver simulation is practiced on the physical remains of the dead before the onset of rigor mortis. This technique has potential benefits for providing real-life in-situ experience for novice providers in health care practices. Evolving ethical views in health care brings into question some of the ethical aspects associated with newly dead cadaver simulation in terms of justification for practice, autonomy, consent, and the need of disclosure. A clear statement of policies and procedures on newly dead cadaver simulation has yet to be implemented. Although there are benefits and disadvantages to an in-situ cadaver simulation, such practices should not be carried out in secrecy as there is no compelling evidence that suggests such training as imperative. Secrecy in these practices is a violation of honor code of nursing ethics. As health care providers, practitioners are obliged to be ethically honest and trustworthy to their patients. The author explores the ethical aspects of using newly dead cadaver simulation in training novice nursing providers to gain competency in various lifesaving skills, which otherwise cannot be practiced on a living individual. The author explores multiple views on cadaver simulation in relation to ethical theories and practices such as consent and disclosure to family.

Newly qualified teachers´ possibilities to get foothold in a lifelong career course

DEFF Research Database (Denmark)

Krøjgaard, Frede; Frederiksen, Lisbeth Angela Lunde

Keyword: Induction program, newly qualified teachers, NQT, retention, professional development In Contrary to many other countries in Europe Denmark does not have any kind of national program regarding teacher induction program (TIP) or support in general to newly qualified teachers what so ever...

Comparison of newly developed anti-bone morphogenetic protein 4 llama-derived antibodies with commercially available BMP4 inhibitors.

Science.gov (United States)

Calpe, Silvia; Correia, Ana C P; Sancho-Serra, Maria Del Carmen; Krishnadath, Kausilia K

2016-01-01

Due to improved understanding of the role of bone morphogenetic protein 4 (BMP4) in an increasing number of diseases, the development of selective inhibitors of BMP4 is an attractive therapeutic option. The currently available BMP4 inhibitors are not suitable as therapeutics because of their low specificity and low effectiveness. Here, we compared newly generated anti-BMP4 llama-derived antibodies (VHHs) with 3 different types of commercially available BMP4 inhibitors, natural antagonists, small molecule BMPR inhibitors and conventional anti-BMP4 monoclonal antibodies. We found that the anti-BMP4 VHHs were as effective as the natural antagonist or small molecule inhibitors, but had higher specificity. We also showed that commercial anti-BMP4 antibodies were inferior in terms of both specificity and effectiveness. These findings might result from the fact that the VHHs C4C4 and C8C8 target a small region within the BMPR1 epitope of BMP4, whereas the commercial antibodies target other areas of the BMP4 molecule. Our results show that the newly developed anti-BMP4 VHHs are promising antibodies with better specificity and effectivity for inhibition of BMP4, making them an attractive tool for research and for therapeutic applications.

Development of a framework for identification of political environmental issues faced by multinational hotel chains in newly industrialized countries in Asia

OpenAIRE

Kim, Chol Yong

1992-01-01

The primary/objective of this study was to develop a framework for identification of political environmental issues faced by multinational hotel chains in newly industrialized countries in Asia. To accomplish the objective, key factors having an impact upon these hotel chains were identified using the Delphi Technique.

Process development

Energy Technology Data Exchange (ETDEWEB)

Schuegerl, K

1984-01-01

The item 'process development' comprises the production of acetonic/butonal with C. acetobylicum and the yeasting of potato waste. The target is to increase productivity by taking the following measures - optimation of media, on-line process analysis, analysis of reaction, mathematic modelling and identification of parameters, process simulation, development of a state estimator with the help of the on-line process analysis and the model, optimization and adaptive control.

Radiation processing of food: role in national development

International Nuclear Information System (INIS)

Sharma, Arun

2002-01-01

Radiation technology can be harnessed in several ways depending on the needs. With adequate storage and packaging regimes it increases the possibilities of handling and distribution of farm produce, thereby improving its supply and management. It can add value to the product by improving its hygiene and quarantine. This is becoming increasingly important for ensuring biosecurity in international trade. Being a newly emerging technology from laboratory to market place, it may face several hurdles. These hurdles may involve engineering or technological challenges during scale-up, post-processing handling and management, problems of security of facilities, consumer attitudes and other unforeseen factors. A small beginning has been made in this direction with a setting up of two technology demonstration units, one for spices and other for onion, by the department. The experience of running these two units and a few more that are contemplated the private sector would probably determine the role the technology would play in future in the national development

Ten Key Steps to Developing a Programme of University Mentoring for Newly Enrolled Students

Directory of Open Access Journals (Sweden)

Raquel Casado-Muñoz

2015-05-01

Full Text Available Peer mentoring or tutoring is an educational guidance method that is growing in universities around the world. Directed at the integration of students over the first year of university studies, it is based on the support and guidance that a more experienced student offers to a recently enrolled fellow student. It is a recent process in Spain which started a little over a decade ago, but each course brings more experiences. This article, derived from research, seeks to identify a series of key steps and ideas to implement this type of programme. The summary of the proposals stems from three main sources: a the experience and assessment of the Mentoring Programme at the University of Burgos; b the review of the peer mentoring programs implemented at 35 Spanish universities; and c the review, comparison and adaptation of formal mentoring to the university according to Perrone (2003.  The outcomes may be especially useful for those universities that wish to start mentoring programmes, and as a source of reflection and comparison for those with greater experience. We believe that special attention should be given on increasing and improving participation in the mentoring of newly enrolled students and on monitoring and assessing the whole process.

Newly graduated nurses' use of knowledge sources

DEFF Research Database (Denmark)

Voldbjerg, Siri Lygum; Grønkjaer, Mette; Sørensen, Erik Elgaard

2016-01-01

AIM: To advance evidence on newly graduated nurses' use of knowledge sources. BACKGROUND: Clinical decisions need to be evidence-based and understanding the knowledge sources that newly graduated nurses use will inform both education and practice. Qualitative studies on newly graduated nurses' use...... underscoring progression in knowledge use and perception of competence and confidence among newly graduated nurses. CONCLUSION: The transition phase, feeling of confidence and ability to use critical thinking and reflection, has a great impact on knowledge sources incorporated in clinical decisions....... The synthesis accentuates that for use of newly graduated nurses' qualifications and skills in evidence-based practice, clinical practice needs to provide a supportive environment which nurtures critical thinking and questions and articulates use of multiple knowledge sources....

Being a team leader: newly registered nurses relate their experiences.

Science.gov (United States)

Ekström, Louise; Idvall, Ewa

2015-01-01

This paper presents a study that explores how newly qualified registered nurses experience their leadership role in the ward-based nursing care team. A nurse's clinical leadership affects the quality of care provided. Newly qualified nurses experience difficulties during the transition period from student to qualified professional and find it challenging to lead nursing care. Twelve nurses were interviewed and the transcribed texts analysed using qualitative content analysis to assess both manifest and latent content. Five themes were identified: feeling stranded; forming well-functioning teams; learning to lead; having the courage, strength, and desire to lead; and ensuring appropriate care. The findings indicate that many factors limit nurses' leadership but some circumstances are supportive. The leadership prerequisites for newly registered nurses need to improve, emphasizing different ways to create a supportive atmosphere that promotes professional development and job satisfaction. To increase nurse retention and promote quality of care, nurse managers need to clarify expectations and guide and support newly qualified nurses in a planned way. © 2013 John Wiley & Sons Ltd.

Development of ODL in a Newly Industrialized Country according to Face-to-Face Contact, ICT, and E-Readiness

Directory of Open Access Journals (Sweden)

J. Marinda van Zyl

2013-03-01

Full Text Available A large number of unqualified and under-qualified in-service teachers are holding back socio-economical development in South Africa, a newly industrialized country. Open and distance learning (ODL provides an innovative strategy and praxis for developing and newly industrialized countries to reach their educational and socio-economical objectives through professional development and training. In order to examine factors which affect the success of ODL offered by the North-West University in South Africa, a qualitative and quantitative research approach is used. Factors examined include face-to-face classroom contact, the implementation and use of ICTs, and e-readiness. The relationships between these factors are also discussed. A questionnaire was administered to 87 teacher-students in four Advanced Certificate in Education (ACE programs to collect quantitative data regarding aspects of their classes and the e-readiness of students. This data was qualitatively elaborated upon by three semi-structured, open-ended focus-group interviews. Besides descriptive statistics, Spearman’s rank-order correlations (r were determined between variables pertaining to negative feelings towards face-to-face classroom contact, ODL as students’ choice of delivery mode, and students’ positive attitude towards information and communication technology (ICT. Combined quantitative and qualitative findings were used to evaluate the effectiveness of contact classes as well as the e-readiness of students towards the attainment of ODL development Phase D. This phase refers to UNESCO’s description of ICT implementation, integration, and use. Relationships (Spearman’s rank-order correlations between ODL, as teacher-students’ choice of educational delivery mode, and aspects of their e-readiness suggest that the e-readiness of teacher-students is implicit to their choice of ODL as educational delivery mode for professional development.

“The Logic of Care” – Parents’ perceptions of the educational process when a child is newly diagnosed with type 1 diabetes

Directory of Open Access Journals (Sweden)

Jönsson Lisbeth

2012-10-01

Full Text Available Abstract Background The number of new cases of type 1 diabetes mellitus (T1DM has increased substantially in recent years and it is now one of the most common long-term endocrine disorders in childhood. In Sweden the child and family are hospitalised in accordance with the national guidelines for one to two weeks at diagnosis. The purpose of this study was to describe parents’ perceptions of the educational process when their child is newly diagnosed with T1DM. Methods Qualitative interviews were performed in the south western part of Sweden with ten mothers and eight fathers of children, diagnosed with T1DM, at three to six months after they had received the diagnosis. The interviews were analysed using deductive content analysis and Mol’s philosophical theory. Results The results show that almost all parents had experienced the educational process as being satisfactory. However, most parents felt that the teaching needed to be adapted to the individual families and to help them to learn to live with diabetes in their everyday lives. Rather than merely teaching according to a fixed schedule and cramming knowledge, the education should be parent-centered and provide time for grief and shock. There should also be a greater emphasis on why certain things should be done rather than on what should be done. The routines learned at the hospital made the efforts to be good parents managing the child’s disease, and continuing to lead a normal family life, a difficult task. Conclusions In order to optimize the educational process for families with children newly diagnosed with T1DM an increased focus on the families’ perceptions might be helpful in that this could lead to further revelations of the educational process thus making it more understandable for the family members involved.

Erosion of newly developed CFCs and Be under disruption heat loads

Science.gov (United States)

Nakamura, K.; Akiba, M.; Araki, M.; Dairaku, M.; Sato, K.; Suzuki, S.; Yokoyama, K.; Linke, J.; Duwe, R.; Bolt, H.; Roedig, M.

1996-10-01

An evaluation of the erosion under disruption heat loads is very important to the lifetime prediction of divertor armour tiles of next fusion devices such as ITER. In particular, erosion data on CFCs (carbon fiber reinforced composites) and beryllium (Be) as the armour materials is urgently required in the ITER design. For CFCs, high heat flux experiments on the newly developed CFCs with high thermal conductivity have been performed under the heat flux of around 800-2000 MW/m 2 and the pulse length of 2-5 ms in JAERI electron beam irradiation systems (JEBIS). As a result, the weight losses of B 4C doped CFCs after heating were almost same to those of the non doped CFC up to 5 wt% boron content. For Be, we have carried out our first disruption experiments on S65/C grade Be specimens in the Juelich divertor test facility in hot cells (JUDITH) facility as a frame work of the J—EU collaboration. The heating conditions were heat loads of 1250-5000 MW/m 2 for 2-8 ms, and the heated area was 3 × 3 mm 2. As a result, the protuberances of the heated area of Be were observed under the lower heat flux.

Erosion of newly developed CFCs and Be under disruption heat loads

International Nuclear Information System (INIS)

Nakamura, K.; Duwe, R.; Bolt, H.; Roedig, M.

1996-01-01

An evaluation of the erosion under disruption heat loads is very important to the lifetime prediction of divertor armour tiles of next fusion devices such as ITER. In particular, erosion data on CFCs (carbon fiber reinforced composites) and beryllium (Be) as the armour materials is urgently required in the ITER design. For CFCs, high heat flux experiments on the newly developed CFCs with high thermal conductivity have been performed under the heat flux of around 800-2000 MW/m 2 and the pulse length of 2-5 ms in JAERI electron beam irradiation systems (JEBIS). As a result, the weight losses of B 4 C doped CFCs after heating were almost same to those of the non doped CFC up to 5 wt% boron content. For Be, we have carried out our first disruption experiments on S65/C grade Be specimens in the Juelich divertor test facility in hot cells (JUDITH) facility as a frame work of the J-EU collaboration. The heating conditions were heat loads of 1250-5000 MW/m 2 for 2-8 ms, and the heated area was 3 x 3 mm 2 . As a result, the protuberances of the heated area of Be were observed under the lower heat flux. (orig.)

Weldability aspects of a newly developed duplex stainless steel LDX 2101

Energy Technology Data Exchange (ETDEWEB)

Westin, E.M. [Avesta Research Centre, Avesta (Sweden). Outokumpu Stainless; Brolund, B. [SSAB Tunnplat, Borlaenge (Sweden); Hertzman, S. [Outokumpu Stainless Research Foundation, Stockholm (Sweden)

2008-06-15

Duplex grades have, due to balanced chemical compositions of both filler and base metals, a weldability that allows for successful welding using a majority of the technically relevant techniques of today. In order to fulfil the performance requirements several aspects must be considered. In the heat affected zone (HAZ) the austenite reformation must be reasonably high and in the weld metal the microstructure must be stable so that e.g. high productivity welding and multi-pass welding are possible, without precipitation of detrimental phases in previous passes. This paper addresses the effect of alloying elements and thermal cycles on phase balance in the high temperature HAZ (HTHAZ) of the newly developed lean duplex grade LDX 2101 (EN 1.4162, UNS S32101). Bead-on-plate welds and simulated weld structures have been produced and investigated using metallography, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The results are analysed using the thermodynamic database Thermo-Calc and a model for phase transformation based on a paraequilibrium assumption for ferrite-austenite transformation. In the temperature region outside the paraequilibrium domain, growth controlled by diffusion of substitutional elements was considered. The analysis follows a model by Cahn regarding grain boundary nucleated growth and the Hillert-Engberg model on kinetics of spherical and planar growth. (orig.)

NUMERICAL MODELLING OF THE SOIL BEHAVIOUR BY USING NEWLY DEVELOPED ADVANCED MATERIAL MODEL

Directory of Open Access Journals (Sweden)

Jan Veselý

2017-02-01

Full Text Available This paper describes a theoretical background, implementation and validation of the newly developed Jardine plastic hardening-softening model (JPHS model, which can be used for numerical modelling of the soils behaviour. Although the JPHS model is based on the elasto-plastic theory, like the Mohr-Coulomb model that is widely used in geotechnics, it contains some improvements, which removes the main disadvantages of the MC model. The presented model is coupled with an isotopically hardening and softening law, non-linear elastic stress-strain law, non-associated elasto-plastic material description and a cap yield surface. The validation of the model is done by comparing the numerical results with real measured data from the laboratory tests and by testing of the model on the real project of the tunnel excavation. The 3D numerical analysis is performed and the comparison between the JPHS, Mohr-Coulomb, Modified Cam-Clay, Hardening small strain model and monitoring in-situ data is done.

Scandinavian exceptionalism? Civic integration and labour market activation for newly arrived immigrants

DEFF Research Database (Denmark)

Breidahl, Karen Nielsen

2017-01-01

models have been resilient: Based on an in-depth historical and comparative analysis of labour market activation policies targeting newly arrived immigrants in Sweden, Norway, and Denmark since the early 1990s, the article contributes to the overall question: To what extent do the institutional pathways...... of the Scandinavian welfare states prevail when confronted with newcomers? Activation policies targeting newly arrived immigrants exemplifies how the ambition of states to promote functional, individual autonomy is also an important, ongoing process in diverse policy areas of the welfare state and not restricted...

Use of newly developed standardized form for interpretation of high-resolution CT in screening for pneumoconiosis

International Nuclear Information System (INIS)

Julien, P.J.; Sider, L.; Silverman, J.M.; Dahlgren, J.; Harber, P.; Bunn, W.

1991-01-01

This paper reports that although the International Labour Office (ILO) standard for interpretation of the posteroanterior chest radiograph has been available for 10 years, there has been no attempt to standardize the high-resolution CT (HRTC) readings for screening of pneumoconiosis. An integrated respirator surveillance program for 87 workers exposed to inorganic dust was conducted. This program consisted of a detailed occupational exposure history, physical symptoms and signs, spirometry, chest radiography, and HRCT. Two groups of workers with known exposure were studied with HRCT. Group 1 had normal spirometry results and chest radiographs, and group 2 had abnormalities at spirometry or on chest radiographs. The HRCT scans were read independently of the clinical findings and chest radiographs. The HRCT scans were interpreted by using an ILO-based standard form developed by the authors for this project. With the newly developed HRCT form, individual descriptive abnormality localized severity, and overall rating systems have been developed and compared for inter- and intraobserver consistency

Optimization of Thermo-Mechanical Processing for Forging of Newly Developed Creep-Resistant Magnesium Alloy ABaX633

Directory of Open Access Journals (Sweden)

Kamineni Pitcheswara Rao

2017-11-01

Full Text Available The compressive strength and creep resistance of cast Mg-6Al-3Ba-3Ca (ABaX633 alloy has been measured in the temperature range of 25 to 250 °C, and compared with that of its predecessor ABaX422. The alloy is stronger and more creep-resistant than ABaX422, and exhibits only a small decrease of yield stress with temperature. The higher strength of ABaX633 is attributed to a larger volume fraction of intermetallic particles (Al, Mg2Ca and Mg21Al3Ba2 in its microstructure. Hot deformation mechanisms in ABaX633 have been characterized by developing a processing map in the temperature and strain rate ranges of 300 to 500 °C and 0.0003 to 10 s−1. The processing map exhibits two workability domains in the temperature and strain rate ranges of: (1 380 to 475 °C and 0.0003 to 0.003 s−1, and (2 480–500 °C and 0.003 to 0.5 s−1. The apparent activation energy values estimated in the above two domains (204 and 216 kJ/mol are higher than that for lattice self-diffusion of Mg, which is attributed to the large back-stress that is caused by the intermetallic particles. Optimum condition for bulk working is 500 °C and 0.01 s−1 at which hot workability will be maximum. Flow instability is exhibited at lower temperatures and higher strain rates, as well as at higher temperatures and higher strain rates. The predictions of the processing map on the workability domains, as well as the instability regimes are fully validated by the forging of a rib-web (cup shaped component under optimized conditions.

Verification of gamma knife based fractionated radiosurgery with newly developed head-thorax phantom

International Nuclear Information System (INIS)

Bisht, Raj Kishor; Kale, Shashank Sharad; Natanasabapathi, Gopishankar; Singh, Manmohan Jit; Agarwal, Deepak; Garg, Ajay; Rath, Goura Kishore; Julka, Pramod Kumar; Kumar, Pratik; Thulkar, Sanjay; Sharma, Bhawani Shankar

2016-01-01

Objective: Purpose of the study is to verify the Gamma Knife Extend™ system (ES) based fractionated stereotactic radiosurgery with newly developed head-thorax phantom. Methods: Phantoms are extensively used to measure radiation dose and verify treatment plan in radiotherapy. A human upper body shaped phantom with thorax was designed to simulate fractionated stereotactic radiosurgery using Extend™ system of Gamma Knife. The central component of the phantom aids in performing radiological precision test, dosimetric evaluation and treatment verification. A hollow right circular cylindrical space of diameter 7.0 cm was created at the centre of this component to place various dosimetric devices using suitable adaptors. The phantom is made of poly methyl methacrylate (PMMA), a transparent thermoplastic material. Two sets of disk assemblies were designed to place dosimetric films in (1) horizontal (xy) and (2) vertical (xz) planes. Specific cylindrical adaptors were designed to place thimble ionization chamber inside phantom for point dose recording along xz axis. EBT3 Gafchromic films were used to analyze and map radiation field. The focal precision test was performed using 4 mm collimator shot in phantom to check radiological accuracy of treatment. The phantom head position within the Extend™ frame was estimated using encoded aperture measurement of repositioning check tool (RCT). For treatment verification, the phantom with inserts for film and ion chamber was scanned in reference treatment position using X-ray computed tomography (CT) machine and acquired stereotactic images were transferred into Leksell Gammaplan (LGP). A patient treatment plan with hypo-fractionated regimen was delivered and identical fractions were compared using EBT3 films and in-house MATLAB codes. Results: RCT measurement showed an overall positional accuracy of 0.265 mm (range 0.223 mm–0.343 mm). Gamma index analysis across fractions exhibited close agreement between LGP and film

Challenges on innovations of newly-developed safety analysis codes

International Nuclear Information System (INIS)

Yang, Yanhua; Zhang, Hao

2016-01-01

With the development of safety analysis method, the safety analysis codes meet more challenges. Three challenges are presented in this paper, which are mathematic model, code design and user interface. Combined with the self-reliance safety analysis code named COSINE, the ways of meeting these requirements are suggested, that is to develop multi-phases, multi-fields and multi-dimension models, to adopt object-oriented code design ideal and to improve the way of modeling, calculation control and data post-processing in the user interface.

Challenges on innovations of newly-developed safety analysis codes

Energy Technology Data Exchange (ETDEWEB)

Yang, Yanhua [Shanghai Jiao Tong Univ. (China). School of Nuclear Science and Engineering; Zhang, Hao [State Nuclear Power Software Development Center, Beijing (China). Beijing Future Science and Technology City

2016-05-15

With the development of safety analysis method, the safety analysis codes meet more challenges. Three challenges are presented in this paper, which are mathematic model, code design and user interface. Combined with the self-reliance safety analysis code named COSINE, the ways of meeting these requirements are suggested, that is to develop multi-phases, multi-fields and multi-dimension models, to adopt object-oriented code design ideal and to improve the way of modeling, calculation control and data post-processing in the user interface.

Characterization of PCBs from computers and mobile phones, and the proposal of newly developed materials for substitution of gold, lead and arsenic.

Science.gov (United States)

Dervišević, Irma; Minić, Duško; Kamberović, Željko; Ćosović, Vladan; Ristić, Mirjana

2013-06-01

In this paper, we have analyzed parts of printed circuit board (PCB) and liquid crystal display (LCD) screens of mobile phones and computers, quantitative and qualitative chemical compositions of individual components, and complete PCBs were determined. Differential thermal analysis (DTA) and differential scanning calorimetry (DSC) methods were used to determine the temperatures of phase transformations, whereas qualitative and quantitative compositions of the samples were determined by X-ray fluorescence spectrometry (XRF), inductively coupled plasma optical emission spectrometry (ICP-OES), and scanning electron microscopy (SEM)-energy dispersive X-ray spectrometry (EDS) analyses. The microstructure of samples was studied by optical microscopy. Based on results of the analysis, a procedure for recycling PCBs is proposed. The emphasis was on the effects that can be achieved in the recycling process by extraction of some parts before the melting process. In addition, newly developed materials can be an adequate substitute for some of the dangerous and harmful materials, such as lead and arsenic are proposed, which is in accordance with the European Union (EU) Restriction of the use of certain hazardous substances (RoHS) directive as well as some alternative materials for use in the electronics industry instead of gold and gold alloys.

Development of the newly advanced alarm system for APWR plant

International Nuclear Information System (INIS)

Shimada, Manabu; Yamamoto, Yoshihiro; Tani, Mamoru; Kobashi, Shuichi

1997-01-01

We have been developing AMCB (Advanced Main Control Board) for APWR consisting of a large overview display and on operator console. We have adopted the alarm prioritizing functions, which are already in use in the existing Japanese PWR plants, for easier identification of the high priority alarms. Moreover, we have developed an alarm system with a large overview display, which presents alarms on the plant process flow diagram. This enhances the location aids and pattern recognition in the alarm identification process. This time, we made further improvement and studies for better and various functions combining a large overview display with a CRT display. We determined the alarm system specification as follows, taking account of flexible alarm recognition processes. (1) The high priority alarms can be identified upon the LOD (large overview display). On the display, the alarms are described on the plant flow diagram, and the alarm status is shown on the fixed position of process or equipment symbols. (2) Other alarms are identified on large overview display and on CRTs using a hierarchical process. (3) The alarm messages are divided into 4 different groups according to the plant systems, thus enabling to undertake the countermeasure operations, using only the CRT. Moreover, we integrated a computerized ARPs (Alarm Response Procedures) into the alarm system. (author). 4 figs, 5 tabs

Development of the newly advanced alarm system for APWR plant

Energy Technology Data Exchange (ETDEWEB)

Shimada, Manabu; Yamamoto, Yoshihiro; Tani, Mamoru; Kobashi, Shuichi [Kansai Electric Power Co., Inc., Osaka (Japan)

1997-09-01

We have been developing AMCB (Advanced Main Control Board) for APWR consisting of a large overview display and on operator console. We have adopted the alarm prioritizing functions, which are already in use in the existing Japanese PWR plants, for easier identification of the high priority alarms. Moreover, we have developed an alarm system with a large overview display, which presents alarms on the plant process flow diagram. This enhances the location aids and pattern recognition in the alarm identification process. This time, we made further improvement and studies for better and various functions combining a large overview display with a CRT display. We determined the alarm system specification as follows, taking account of flexible alarm recognition processes. (1) The high priority alarms can be identified upon the LOD (large overview display). On the display, the alarms are described on the plant flow diagram, and the alarm status is shown on the fixed position of process or equipment symbols. (2) Other alarms are identified on large overview display and on CRTs using a hierarchical process. (3) The alarm messages are divided into 4 different groups according to the plant systems, thus enabling to undertake the countermeasure operations, using only the CRT. Moreover, we integrated a computerized ARPs (Alarm Response Procedures) into the alarm system. (author). 4 figs, 5 tabs.

Newly invented biobased materials from low-carbon, diverted waste fibers: research methods, testing, and full-scale application in a case study structure

Science.gov (United States)

Julee A Herdt; John Hunt; Kellen Schauermann

2016-01-01

This project demonstrates newly invented, biobased construction materials developed by applying lowcarbon, biomass waste sources through the Authors’ engineered fiber processes and technology. If manufactured and applied large-scale the project inventions can divert large volumes of cellulose waste into high-performance, low embodied energy, environmental construction...

Flagellation of Pseudomonas aeruginosa in newly divided cells

Science.gov (United States)

Zhao, Kun; Lee, Calvin; Anda, Jaime; Wong, Gerard

2015-03-01

For monotrichous bacteria, Pseudomonas aeruginosa, after cell division, one daughter cell inherits the old flagellum from its mother cell, and the other grows a new flagellum during or after cell division. It had been shown that the new flagellum grows at the distal pole of the dividing cell when the two daughter cells haven't completely separated. However, for those daughter cells who grow new flagella after division, it still remains unknown at which pole the new flagellum will grow. Here, by combining our newly developed bacteria family tree tracking techniques with genetic manipulation method, we showed that for the daughter cell who did not inherit the old flagellum, a new flagellum has about 90% chances to grow at the newly formed pole. We proposed a model for flagellation of P. aeruginosa.

Surface ultrastuctures of the human laryngeal mucosa - observation by an newly developed technique of SEM cinematography

International Nuclear Information System (INIS)

Ohyama, M.; Ohno, I.; Fujita, T.; Adachi, K.

1981-01-01

With the newly-developed techniques of SEM cinematography, surface ultrastructures of the human normal and pathological laryngeal mucosa were demonstrated. The high specialization of the laryngeal mucosa with its marked regional differences stresses the fact that even the squamous epithelium and nonciliated epithelium may play a role of utmost importance. All specimens were obtained after laryngectomy from 10 patients affected by laryngeal cancer which had been treated with or without preoperative irradiation of Lineac in total doses of 3,500-4,500 rad. Special attention was paid to the occurrence of microvilli and microplicae in the normal and pathological mucosa of the larynx, and their morphological and physiological significances were discussed briefly. (Auth.)

Transferability of Newly Developed Pear SSR Markers to Other Rosaceae Species.

Science.gov (United States)

Fan, L; Zhang, M-Y; Liu, Q-Z; Li, L-T; Song, Y; Wang, L-F; Zhang, S-L; Wu, J

2013-01-01

A set of 120 simple sequence repeats (SSRs) was developed from the newly assembled pear sequence and evaluated for polymorphisms in seven genotypes of pear from different genetic backgrounds. Of these, 67 (55.8 %) primer pairs produced polymorphic amplifications. Together, the 67 SSRs detected 277 alleles with an average of 4.13 per locus. Sequencing of the amplification products from randomly picked loci NAUPy31a and NAUpy53a verified the presence of the SSR loci. When the 67 primer pairs were tested on 96 individual members of eight species in the Rosaceae family, 61.2 % (41/67) of the tested SSRs successfully amplified a PCR product in at least one of the Rosaceae genera. The transferability from pear to different species varied from 58.2 % (apple) to 11.9 % (cherry). The ratio of transferability also reflected the closer relationships within Maloideae over Prunoideae. Two pear SSR markers, NAUpy43c and NAUpy55k, could distinguish the 20 different apple genotypes thoroughly, and UPGMA cluster analysis grouped them into three groups at the similarity level of 0.56. The high level of polymorphism and good transferability of pear SSRs to Rosaceae species indicate their promise for application to future molecular screening, map construction, and comparative genomic studies among pears and other Rosaceae species.

Mechanism and application of a newly developed pressure casting process: horizontal squeeze casting

Directory of Open Access Journals (Sweden)

Li Peijie

2014-07-01

Full Text Available Compared to traditional high-pressure die casting (HPDC, horizontal squeeze casting (HSC is a more promising way to fabricate high-integrity castings, owing to a reduced number of gas and shrinkage porosities produced in the casting. In this paper, the differences between HSC and HPDC are assessed, through which it is shown that the cavity filling velocity and the size of the gating system to be the most notable differences. Equipment development and related applications are also reviewed. Furthermore, numerical simulation is used to analyze the three fundamental characteristics of HSC: slow cavity filling, squeeze feeding and slow sleeve filling. From this, a selection principle is given based on the three related critical casting parameters: cavity filling velocity, gate size and sleeve filling velocity. Finally, two specific applications of HSC are introduced, and the future direction of HSC development is discussed.

Newly Homeless Youth Typically Return Home

OpenAIRE

Milburn, Norweeta G.; Rosenthal, Doreen; Rotheram-Borus, Mary Jane; Mallett, Shelley; Batterham, Philip; Rice, Eric; Solorio, Rosa

2007-01-01

165 newly homeless adolescents from Melbourne, Australia and 261 from Los Angeles, United States were surveyed and followed for two years. Most newly homeless adolescents returned home (70% U.S., 47% Australia) for significant amounts of time (39% U.S., 17% Australia more than 12 months) within two years of becoming homeless.

Research in the field of development of a new generation of metal-processing machines

Directory of Open Access Journals (Sweden)

L.Tanovič

2017-12-01

Full Text Available The paper presents a review of research in the field of development of a new generation of metal-working machines for manufacturing high-precision products with dimensions of several micrometers from various materials. Presented are several new, newly created micro-machines that have the ability to manufacture products of a wide range. Studies in the field of metalworking machines and robots of a new generation with parallel kinematics, creation of machining systems for multi-axis machining, improvement and application of controllable systems, testing of processing systems in production conditions, which are conducted at the Machine-Building Faculty of the Belgrade University (Serbia are considered.

THE NEXUS BETWEEN ENERGY CONSUMPTION AND FINANCIAL DEVELOPMENT WITH ASYMMETRIC CAUSALITY TEST: NEW EVIDENCE FROM NEWLY INDUSTRIALIZED COUNTRIES

Directory of Open Access Journals (Sweden)

Feyyaz Zeren

2014-01-01

Full Text Available In this study, the relationship between energy consumption and financial development is investigated via Hatemi-J asymmetric causality test (2012 which is able to separate positive and negative shocks in analysis. In order to determine different dimensions of financial system, deposit money bank assets to GDP (dbagdp, financial system deposits to GDP (fdgdp and private credit to GDP (pcrdbgdp were used as three different indicators. As a result of this study on Newly Industrialized 7 Countries spanning the period 1971 till 2010, both positive and negative shocks existed for Malaysia and Mexico, causality from energy consumption to financial developments emerged for Philippines in only negative shocks. While two-way causality occurred for India, Turkey and Thailand, there was not for South Africa.

A multidisciplinary prostate cancer clinic for newly diagnosed patients: developing the role of the advanced practice nurse.

Science.gov (United States)

Madsen, Lydia T; Craig, Catherine; Kuban, Deborah

2009-06-01

Newly diagnosed patients with prostate cancer have various treatment options, and a multidisciplinary prostate cancer clinic (MPCC) can present all options in a single setting. An MPCC was started in 2004 at the University of Texas M.D. Anderson Cancer Center, and 258 patients with prostate cancer were evaluated in its first year. The clinic expanded in 2006 and an oncology advanced practice nurse (APN) was recruited to address specific objectives. The APN role was used to implement a quality-of-life protocol, provide detailed patient education (including a treatment summary and care plan), and serve as a single point of contact as patients move toward a treatment decision. Formal evaluation of the MPCC showed that patients were satisfied with this approach to the complex decision-making process in prostate cancer.

Duplex ultrasound: Indications and findings in a newly created ...

African Journals Online (AJOL)

Duplex ultrasound: Indications and findings in a newly created facility at the University of Calabar Teaching Hospital, Calabar. ... It is recommended that timely referrals be made, and mobile Doppler units be acquired to save more lives and limbs in the developing world. Keywords: Calabar, deep venous thrombosis, duplex ...

A newly developed grab sampling system for collecting stratospheric air over Antarctica

Directory of Open Access Journals (Sweden)

Hideyuki Honda

1996-07-01

Full Text Available In order to measure the concentrations of various minor constituents and their isotopic ratios in the stratosphere over Antarctica, a simple grab sampling system was newly developed. The sampling system was designed to be launched by a small number of personnel using a rubber balloon under severe experimental conditions. Special attention was paid to minimize the contamination of sample air, as well as to allow easy handling of the system. The sampler consisted mainly of a 15l sample container with electromagnetic and manual valves, control electronics for executing the air sampling procedures and sending the position and status information of the sampler to the ground station, batteries and a transmitter. All these parts were assembled in an aluminum frame gondola with a shock absorbing system for landing. The sampler was equipped with a turn-over mechanism of the gondola to minimize contamination from the gondola, as well as with a GPS receiver and a rawinsonde for its tracking. Total weight of the sampler was about 11kg. To receive, display and store the position and status data of the sampling system at the ground station, a simple data acquisition system with a portable receiver and a microcomputer was also developed. A new gas handling system was prepared to simplify the injection of He gas into the balloon. For air sampling experiments, three sampling systems were launched at Syowa Station (69°00′S, 39°35′E, Antarctica and then recovered on sea ice near the station on January 22 and 25,1996.

Evaluation of newly developed veterinary portable blood glucose meter with hematocrit correction in dogs and cats.

Science.gov (United States)

Mori, Akihiro; Oda, Hitomi; Onozawa, Eri; Shono, Saori; Sako, Toshinori

2017-10-07

This study evaluated the accuracy of a newly developed veterinary portable blood glucose meter (PBGM) with hematocrit correction in dogs and cats. Sixty-one dogs and 31 cats were used for the current study. Blood samples were obtained from each dog and cat one to six times. Acceptable results were obtained in error grid analysis between PBGM and reference method values (glucose oxidation methods) in both dogs and cats. Bland-Altman plot analysis revealed a mean difference between the PBGM value and reference method value of -1.975 mg/dl (bias) in dogs and 1.339 mg/dl (bias) in cats. Hematocrit values did not affect the results of the veterinary PBGM. Therefore, this veterinary PBGM is clinically useful in dogs and cats.

Dry fermentation of manure with straw in continuous plug flow reactor: Reactor development and process stability at different loading rates.

Science.gov (United States)

Patinvoh, Regina J; Kalantar Mehrjerdi, Adib; Sárvári Horváth, Ilona; Taherzadeh, Mohammad J

2017-01-01

In this work, a plug flow reactor was developed for continuous dry digestion processes and its efficiency was investigated using untreated manure bedded with straw at 22% total solids content. This newly developed reactor worked successfully for 230days at increasing organic loading rates of 2.8, 4.2 and 6gVS/L/d and retention times of 60, 40 and 28days, respectively. Organic loading rates up to 4.2gVS/L/d gave a better process stability, with methane yields up to 0.163LCH 4 /gVS added /d which is 56% of the theoretical yield. Further increase of organic loading rate to 6gVS/L/d caused process instability with lower volatile solid removal efficiency and cellulose degradation. Copyright © 2016 Elsevier Ltd. All rights reserved.

A newly developed lubricant, chitosan laurate, in the manufacture of acetaminophen tablets.

Science.gov (United States)

Bani-Jaber, Ahmad; Kobayashi, Asuka; Yamada, Kyohei; Haj-Ali, Dana; Uchimoto, Takeaki; Iwao, Yasunori; Noguchi, Shuji; Itai, Shigeru

2015-04-10

To study the usefulness of chitosan laurate (CS-LA), a newly developed chitosan salt, as a lubricant, lubrication properties such as the pressure transmission ratio and ejection force were determined at different concentrations of CS-LA in tableting. In addition, tablet properties such as the tensile strength, disintegration time, and dissolution behavior, were also determined. When CS-LA was mixed at concentrations of 0.1%-3.0%, the pressure transmission ratio was increased in a concentration-dependent manner, and the value at a CS-LA concentration of 3% was equal to that of magnesium stearate (Mg-St), a widely used lubricant. Additionally, a reduction in the ejection force was observed at a concentration from 1%, proving that CS-LA has good lubrication performance. A prolonged disintegration time and decreased tensile strength, which are known disadvantages of Mg-St, were not observed with CS-LA. Furthermore, with CS-LA, retardation of dissolution of the drug from the tablets was not observed. Conjugation of CS with LA was found to be quite important for both lubricant and tablet properties. In conclusion, CS-LA should be useful as an alternative lubricant to Mg-St. Copyright © 2015 Elsevier B.V. All rights reserved.

Immunoparesis in newly diagnosed Multiple Myeloma patients

DEFF Research Database (Denmark)

Sorrig, Rasmus; Klausen, Tobias W.; Salomo, Morten

2017-01-01

Immunoparesis (hypogammaglobulinemia) is associated to an unfavorable prognosis in newly diagnosed Multiple myeloma (MM) patients. However, this finding has not been validated in an unselected population-based cohort. We analyzed 2558 newly diagnosed MM patients in the Danish Multiple Myeloma...

Characterization and process development for the selective removal of Sn, Sb, and As from anode slime obtained from electrolytic copper refining

Directory of Open Access Journals (Sweden)

Steinlechner S.

2018-01-01

Full Text Available The aim of this work was to develop a process for the removal of Sn, Sb and As from anode slime out of copper refinery to disburden a subsequent pyrometallurgical processing for precious metals refinement. For this reason, a detailed literature survey was conducted, followed by a characterization to find the present compounds/alloys and their morphology. A newly developed process concept for the separate extraction of the afore mentioned three target metals was developed and verified by leaching experiments, combined with thermodynamic calculations on their behavior under varying conditions. In this context, the influence of leaching temperature, alkalinity of leaching solution, and solid-liquid ration were evaluated on the extraction yields of Sn, As, and Sb, as well as how to exploit these findings to obtain separate streams enriched in the respective metals.

Process development

International Nuclear Information System (INIS)

Zapata G, G.

1989-01-01

Process development: The paper describes the organization and laboratory facilities of the group working on radioactive ore processing studies. Contains a review of the carried research and the plans for the next future. A list of the published reports is also presented

Top Information Need Priorities of Older Adults Newly Diagnosed With Active Myeloma.

Science.gov (United States)

Tariman, Joseph D; Doorenbos, Ardith; Schepp, Karen G; Singhal, Seema; Berry, Donna L

2015-01-01

Prioritizing patients' information needs maximizes efficiency. This study examined the information sources and priorities in a sample of older adults newly diagnosed with symptomatic myeloma requiring immediate therapy. An association analysis of whether information needs were influenced by sociodemographic variables such as age, gender, education, marital status, and income was also conducted. The Information Needs Questionnaire (INQ) and an investigator-developed interview schedule were administered to 20 older adults diagnosed with symptomatic myeloma during a 30- to 45-minute semistructured interview. We found that older adults newly diagnosed with symptomatic myeloma have different priorities of information needs when compared with younger patients diagnosed with various types of cancer. The top three priorities related to treatment, prognosis, and self-care. Sociodemographic variables did not influence the priorities of information needs among older adults with symptomatic myeloma. The Internet, physicians, family, and friends were among the top sources of information. Advanced practitioners in oncology should support and identify interventions that can enhance patients' learning process from these sources. Well poised to assist patients in searching credible and reliable Internet sources, advanced practitioners in oncology can provide patient education about different treatments and the impact of such treatments on prognosis (e.g., overall survival and likelihood of cure).

A newly developed Fe-doped calcium sulfide nanoparticles with magnetic property for cancer hyperthermia

Science.gov (United States)

Wu, Steven Yueh-Hsiu; Tseng, Ching-Li; Lin, Feng-Huei

2010-05-01

In this study, a magnetic iron-doped calcium sulfide (Fe-CaS) nanoparticle was newly developed and studied for the purpose of hyperthermia due to its promising magnetic property, adequate biodegradation rate, and relatively good biocompatibility. Fe-CaS nanoparticles were synthesized by a wet chemical co-precipitation process with heat treatment in a N2 atmosphere, and were subsequently cooled in N2 and exposed to air at a low temperature. The crystal structure of the Fe-CaS nanoparticles was similar to that of the CaS, which was identified by an X-ray diffractometer (XRD). The particle size was less than 40 nm based on a Debye-Scherrer equation and transmission electron microscope (TEM) examination. Magnetic properties obtained from the SQUID magnetometer demonstrated that the synthesized CaS was a diamagnetic property. Once the Fe ions were doped, the synthesized Fe-CaS converted into paramagnetism which showed no hysteresis loop. Having been heated above 600 °C in N2, the Fe-CaS showed a promising magnetic property to produce enough energy to increase the temperature for hyperthermia. 10 mg/ml of the Fe-CaS was able to generate heat to elevate the media temperature over 42.5 °C within 6 min. The area of the hysteresis loop increased with the increasing of the treated temperature, especially at 800 °C for 1 h. This is because more Fe ions replaced Ca ions in the lattice at the higher heat treatment temperature. The heat production was also increasing with the increasing of heat treatment temperature, which resulted in an adequate specific absorption ratio (SAR) value, which was found to be 45.47 W/g at 37 °C under an alternative magnetic field of f = 750 KHz , H = 10 Oe. The in vitro biocompatibility test of the synthesized Fe-CaS nanoparticles examined by the LDH assay showed no cytotoxicity to 3T3 fibroblast. The result of in vitro cell hyperthermia shows that under magnetic field the Fe-CaS nanoparticles were able to generate heat and kill the CT-26 cancer

A newly developed Fe-doped calcium sulfide nanoparticles with magnetic property for cancer hyperthermia

International Nuclear Information System (INIS)

Wu, Steven Yueh-Hsiu; Tseng, Ching-Li; Lin, Feng-Huei

2010-01-01

In this study, a magnetic iron-doped calcium sulfide (Fe-CaS) nanoparticle was newly developed and studied for the purpose of hyperthermia due to its promising magnetic property, adequate biodegradation rate, and relatively good biocompatibility. Fe-CaS nanoparticles were synthesized by a wet chemical co-precipitation process with heat treatment in a N 2 atmosphere, and were subsequently cooled in N 2 and exposed to air at a low temperature. The crystal structure of the Fe-CaS nanoparticles was similar to that of the CaS, which was identified by an X-ray diffractometer (XRD). The particle size was less than 40 nm based on a Debye-Scherrer equation and transmission electron microscope (TEM) examination. Magnetic properties obtained from the SQUID magnetometer demonstrated that the synthesized CaS was a diamagnetic property. Once the Fe ions were doped, the synthesized Fe-CaS converted into paramagnetism which showed no hysteresis loop. Having been heated above 600 o C in N 2 , the Fe-CaS showed a promising magnetic property to produce enough energy to increase the temperature for hyperthermia. 10 mg/ml of the Fe-CaS was able to generate heat to elevate the media temperature over 42.5 o C within 6 min. The area of the hysteresis loop increased with the increasing of the treated temperature, especially at 800 o C for 1 h. This is because more Fe ions replaced Ca ions in the lattice at the higher heat treatment temperature. The heat production was also increasing with the increasing of heat treatment temperature, which resulted in an adequate specific absorption ratio (SAR) value, which was found to be 45.47 W/g at 37 o C under an alternative magnetic field of f = 750 KHz, H = 10 Oe. The in vitro biocompatibility test of the synthesized Fe-CaS nanoparticles examined by the LDH assay showed no cytotoxicity to 3T3 fibroblast. The result of in vitro cell hyperthermia shows that under magnetic field the Fe-CaS nanoparticles were able to generate heat and kill the CT-26

How inverse solver technologies can support die face development and process planning in the automotive industry

Science.gov (United States)

Huhn, Stefan; Peeling, Derek; Burkart, Maximilian

2017-10-01

With the availability of die face design tools and incremental solver technologies to provide detailed forming feasibility results in a timely fashion, the use of inverse solver technologies and resulting process improvements during the product development process of stamped parts often is underestimated. This paper presents some applications of inverse technologies that are currently used in the automotive industry to streamline the product development process and greatly increase the quality of a developed process and the resulting product. The first focus is on the so-called target strain technology. Application examples will show how inverse forming analysis can be applied to support the process engineer during the development of a die face geometry for Class `A' panels. The drawing process is greatly affected by the die face design and the process designer has to ensure that the resulting drawn panel will meet specific requirements regarding surface quality and a minimum strain distribution to ensure dent resistance. The target strain technology provides almost immediate feedback to the process engineer during the die face design process if a specific change of the die face design will help to achieve these specific requirements or will be counterproductive. The paper will further show how an optimization of the material flow can be achieved through the use of a newly developed technology called Sculptured Die Face (SDF). The die face generation in SDF is more suited to be used in optimization loops than any other conventional die face design technology based on cross section design. A second focus in this paper is on the use of inverse solver technologies for secondary forming operations. The paper will show how the application of inverse technology can be used to accurately and quickly develop trim lines on simple as well as on complex support geometries.

Generational differences among newly licensed registered nurses.

Science.gov (United States)

Keepnews, David M; Brewer, Carol S; Kovner, Christine T; Shin, Juh Hyun

2010-01-01

Responses of 2369 newly licensed registered nurses from 3 generational cohorts-Baby Boomers, Generation X, and Generation Y-were studied to identify differences in their characteristics, work-related experiences, and attitudes. These responses revealed significant differences among generations in: job satisfaction, organizational commitment, work motivation, work-to-family conflict, family-to-work conflict, distributive justice, promotional opportunities, supervisory support, mentor support, procedural justice, and perceptions of local job opportunities. Health organizations and their leaders need to anticipate intergenerational differences among newly licensed nurses and should provide for supportive working environments that recognize those differences. Orientation and residency programs for newly licensed nurses should be tailored to the varying needs of different generations. Future research should focus on evaluating the effectiveness of orientation and residency programs with regard to different generations so that these programs can be tailored to meet the varying needs of newly licensed nurses at the start of their careers. Copyright 2010 Mosby, Inc. All rights reserved.

Sport as a context for integration:newly arrived immigrant children in Sweden drawing sporting experiences

OpenAIRE

Hertting, Krister; Karlefors, Inger

2013-01-01

Sport is a global phenomenon, which can make sport an important arena for integration into new societies. However, sport is also an expression of national culture and identities. The aim of this study is to explore images and experiences that newly-arrived immigrant children in Sweden have about sport in their country of origin, and challenges that can arise in processes of integration through sport. We asked 20 newly arrived children aged 10 to 13 to make drawings about sporting experiences ...

Mentorship for newly appointed physicians: a strategy for enhancing patient safety?

Science.gov (United States)

Harrison, Reema; McClean, Serwaa; Lawton, Rebecca; Wright, John; Kay, Clive

2014-09-01

Mentorship is an increasingly popular innovation from business and industry that is being applied in health-care contexts. This paper explores the concept of mentorship for newly appointed physicians in their first substantive senior post, and specifically its utilization to enhance patient safety. Semi-structured face to face and telephone interviews with Medical Directors (n = 5), Deputy Medical Directors (n = 4), and Clinical Directors (n = 6) from 9 acute NHS Trusts in the Yorkshire and Humber region in the north of England. A focused thematic analysis was used. A number of beneficial outcomes were associated with mentorship for newly appointed physicians including greater personal and professional support, organizational commitment, and general well-being. Providing newly appointed senior physicians with support through mentorship was considered to enhance the safety of patient care. Mentorship may prevent or reduce active failures, be used to identify threats in the local working environment, and in the longer term, address latent threats to safety within the organization by encouraging a healthier safety culture. Offering mentorship to all newly appointed physicians in their first substantive post in health care may be a useful strategy to support the development of their clinical, professional, and personal skills in this transitional period that may also enhance the safety of patient care.

Hope, emotion regulation, and psychosocial well-being in patients newly diagnosed with cancer.

Science.gov (United States)

Peh, Chao Xu; Kua, Ee Heok; Mahendran, Rathi

2016-05-01

Patients newly diagnosed with cancer are often confronted with feelings of uncertainty and life threat. A significant proportion may report impairments in psychosocial well-being. Previous studies examining protective psychological factors such as hope and emotion regulation (ER) have yet to investigate these processes concurrently within a common self-regulation framework and/or focus on newly diagnosed patients. The present study aimed to examine how hope and ER may relate to psychosocial outcomes of patients newly diagnosed with cancer. The present study used a cross-sectional design with self-report questionnaires. Participants were newly diagnosed patients (N = 101) recruited from three cancer therapy clinics in a hospital. Patients completed measures of hope, ER (cognitive reappraisal and expressive suppression), and psychosocial well-being (life satisfaction and negative affectivity). Findings showed that (1) hope and reappraisal, but not suppression, were associated with well-being and (2) the interaction between hope and reappraisal was associated with well-being; reappraisal was not associated with well-being in high hope patients, while high reappraisal was associated with better well-being in low hope patients. Individual differences in hope and reappraisal appeared to be associated with psychosocial outcomes in newly diagnosed cancer patients. Hopeful thinking appeared to benefit patients' psychosocial well-being. In addition, an interaction effect between hope and reappraisal suggested that reappraisal as an ER strategy may be particularly adaptive for patients with low hope.

[An Introduction to A Newly-developed "Acupuncture Needle Manipulation Training-evaluation System" Based on Optical Motion Capture Technique].

Science.gov (United States)

Zhang, Ao; Yan, Xing-Ke; Liu, An-Guo

2016-12-25

In the present paper, the authors introduce a newly-developed "Acupuncture Needle Manipulation Training-evaluation System" based on optical motion capture technique. It is composed of two parts, sensor and software, and overcomes some shortages of mechanical motion capture technique. This device is able to analyze the data of operations of the pressing-hand and needle-insertion hand during acupuncture performance and its software contains personal computer (PC) version, Android version, and Internetwork Operating System (IOS) Apple version. It is competent in recording and analyzing information of any ope-rator's needling manipulations, and is quite helpful for teachers in teaching, training and examining students in clinical practice.

Management of Newly Diagnosed Atrial Fibrillation in an Outpatient Clinic Setting

DEFF Research Database (Denmark)

Thrysoee, Lars; Strömberg, Anna; Brandes, Axel

2018-01-01

fibrillation is not a fatal disease in itself was very important for patients. At the same time, visiting the clinic was overwhelming, information was difficult to understand, and patients found it difficult to be involved in decision-making. CONCLUSIONS: This study indicates that patients were uncertain......AIMS: To gain in-depth knowledge of patients' experiences of the consultation processes at a multidisciplinary atrial fibrillation outpatient clinic in a university hospital in Denmark. BACKGROUND: Atrial fibrillation is the most common cardiac arrhythmia associated with morbidity and mortality...... if not diagnosed and treated as recommended. Patients with newly diagnosed atrial fibrillation preferably should be managed in an outpatient setting which includes medical examination, patient education and decision making on medical therapy. DESIGN: This is a qualitative study of 14 patients newly diagnosed...

Newly democratic Mongolia offering exploration contracts

International Nuclear Information System (INIS)

Penttila, W.C.

1992-01-01

This paper reports that Mongolia, formerly the Mongolian People's Republic, is working to open its exploration prospects to international operators as it emerges as the world's 15th largest independent nation. The country, about the same size as Alaska with a population of 2 million, held its first free election in July 1990. The newly elected government drafted a constitution that took effect Feb. 12, 1992. The document modifies the previous government's structures to eliminate bureaucracy and allows for political pluralism. At the same time, the government is formulating energy policies, state oil company structure, and resource development philosophy

Comparison of a newly developed binary typing with ribotyping and multilocus sequence typing methods for Clostridium difficile.

Science.gov (United States)

Li, Zhirong; Liu, Xiaolei; Zhao, Jianhong; Xu, Kaiyue; Tian, Tiantian; Yang, Jing; Qiang, Cuixin; Shi, Dongyan; Wei, Honglian; Sun, Suju; Cui, Qingqing; Li, Ruxin; Niu, Yanan; Huang, Bixing

2018-04-01

Clostridium difficile is the causative pathogen for antibiotic-related nosocomial diarrhea. For epidemiological study and identification of virulent clones, a new binary typing method was developed for C. difficile in this study. The usefulness of this newly developed optimized 10-loci binary typing method was compared with two widely used methods ribotyping and multilocus sequence typing (MLST) in 189 C. difficile samples. The binary typing, ribotyping and MLST typed the samples into 53 binary types (BTs), 26 ribotypes (RTs), and 33 MLST sequence types (STs), respectively. The typing ability of the binary method was better than that of either ribotyping or MLST expressed in Simpson Index (SI) at 0.937, 0.892 and 0.859, respectively. The ease of testing, portability and cost-effectiveness of the new binary typing would make it a useful typing alternative for outbreak investigations within healthcare facilities and epidemiological research. Copyright © 2018 Elsevier B.V. All rights reserved.

Who Is Doing Well? A Typology of Newly Homeless Adolescents

Science.gov (United States)

Milburn, Norweeta; Liang, Li-Jung; Lee, Sung-Jae; Rotheram-Borus, Mary Jane; Rosenthal, Doreen; Mallett, Shelley; Lightfoot, Marguerita; Lester, Patricia

2009-01-01

There is growing evidence to support developing new typologies for homeless adolescents. Current typologies focus on the risks associated with being homeless, with less consideration of the positive attributes of homeless adolescents. The authors examined both risk and protective factors in a sample of newly homeless adolescents. Using cluster…

Newly graduated nurses' empowerment regarding professional competence and other work-related factors.

Science.gov (United States)

Kuokkanen, Liisa; Leino-Kilpi, Helena; Numminen, Olivia; Isoaho, Hannu; Flinkman, Mervi; Meretoja, Riitta

2016-01-01

Although both nurse empowerment and competence are fundamental concepts of describing newly graduated nurses' professional development and job satisfaction, only few studies exist on the relationship between these concepts. Therefore, the purpose of this study was to determine how newly graduated nurses assess their empowerment and to clarify professional competence compared to other work-related factors. A descriptive, cross-sectional and correlational design was applied. The sample comprised newly graduated nurses (n = 318) in Finland. Empowerment was measured using the 19-item Qualities of an Empowered Nurse scale and the Nurse Competence Scale measured nurses' self-assessed generic competence. In addition to demographic data, the background data included employment sector (public/private), job satisfaction, intent to change/leave job, work schedule (shifts/business hours) and assessments of the quality of care in the workplace. The data were analysed statistically by using Spearman's correlation coefficient as well as the One-Way and Multivariate Analysis of Variance. Cronbach's alpha coefficient was used to estimate the internal consistency. Newly graduated nurses perceived their level of empowerment and competence fairly high. The association between nurse empowerment and professional competence was statistically significant. Other variables correlating positively to empowerment included employment sector, age, job satisfaction, intent to change job, work schedule, and satisfaction with the quality of care in the work unit. The study indicates competence had the strongest effect on newly graduated nurses' empowerment. New graduates need support and career opportunities. In the future, nurses' further education and nurse managers' resources for supporting and empowering nurses should respond to the newly graduated nurses' requisites for attractive and meaningful work.

Use of a newly developed active thermal neutron detector for in-phantom measurements in a medical LINAC

Energy Technology Data Exchange (ETDEWEB)

Bodogni, R.; Sanchez-Doblado, F.; Pola, A.; Gentile, A.; Esposito, A.; Gomez-ros, J. M.; Pressello, M. C.; Lagares, J. I.; Terron, J. A.; Gomez, F.

2013-07-01

In this work a newly developed active thermal neutron detector, based on a solid state analog device, was used to determine the thermal neutron fluence in selected positions of a simplified human phantom undergoing radiotherapy with a 15 MV LINAC. The results are compared with TLD, the predictions from a Monte Carlo simulation and with measurements indirectly performed with a digital device, located far from the phantom, inside the treatment room. In this work only TLD comparison is presented. Since active neutron instruments are usually affected by systematic deviations when used in a pulsed field with large photon background, the new detector offered in this work may represent an innovative and useful tool for neutron evaluations in accelerator-based radiotherapy. (Author)

Adapted to change: The rapid development of symbiosis in newly settled, fast-maturing chemosymbiotic mussels in the deep sea.

Science.gov (United States)

Laming, Sven R; Duperron, Sébastien; Gaudron, Sylvie M; Hilário, Ana; Cunha, Marina R

2015-12-01

Symbioses between microbiota and marine metazoa occur globally at chemosynthetic habitats facing imminent threat from anthropogenic disturbance, yet little is known concerning the role of symbiosis during early development in chemosymbiotic metazoans: a critical period in any benthic species' lifecycle. The emerging symbiosis of Idas (sensu lato) simpsoni mussels undergoing development is assessed over a post-larval-to-adult size spectrum using histology and fluorescence in situ hybridisation (FISH). Post-larval development shows similarities to that of both heterotrophic and chemosymbiotic mussels. Data from newly settled specimens confirm aposymbiotic, planktotrophic larval development. Sulphur-oxidising (SOX) symbionts subsequently colonise multiple exposed, non-ciliated epithelia shortly after metamorphosis, but only become abundant on gills as these expand with greater host size. This wide-spread bathymodiolin recorded from sulphidic wood, bone and cold-seep habitats, displays a suite of adaptive traits that could buffer against anthropogenic disturbance. Copyright © 2015 Elsevier Ltd. All rights reserved.

FY 2000 study report on the study on technological development of the chemical processes of the next generation; 2000 nendo jisedai kagaku process gijutsu kaihatsu ni kansuru chosa kenkyu hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-03-01

The technological development of the innovative chemical reaction processes is studied, in order to accomplish further energy saving, and reduction of resource consumption and environmental loads. Described herein are the FY 2000 study results. The program for systematization of the next-generation chemical processes systematically pigeonholes the undergoing projects and subjects to be studied, based on the principles of simplification, and sets the study fields of organic bulk chemicals, organic fine chemicals, highpolymer materials and inorganic materials. The program for investigation on next-generation chemical processes reviews creation and technological use of tailor-made biocatalysts, polymer materials which utilize wood resources, tailor-made reaction process engineering for handling fine particles in high-temperature reaction fields, production and processing of materials for high-performance polymer batteries, and extreme energy saving process for polyolefins, and proposes the revisions. The newly proposed study themes include novel C1 catalytic processes toward minimal wastes, and high utilization of biotechnology for novel processes to create materials. (NEDO)

Newly developed low-temperature scanning tunneling microscope and its application to the study of superconducting materials

International Nuclear Information System (INIS)

Gao, F.; Dai, C.; Chen, Z.; Huang, G.; Bai, C.; Tao, H.; Yin, B.; Yang, Q.; Zhao, Z.

1994-01-01

A newly developed scanning tunneling microscope (STM) capable of operating at room temperature, 77 K, and 4.2 K is presented. This compact STM has a highly symmetric and rigid tunneling unit designed as an integral frame except the coarse and fine adjustment parts. The tunneling unit is incorporated into a small vacuum chamber that is usually pumped down to 2x10 -4 Pa to avoid water contamination. The fine mechanic adjustment makes the tip approach the sample in 5 nm steps. The coarse adjustment not only changes the distance between the tip and the sample, but also adjusts the tip to be normal to the surface of the sample. With this low-temperature STM atomic resolution images of Bi-2212 single-crystal and large-scale topographies of a YBa 2 Cu 3 O 7 thin film are observed at 77 K

Feasibility and preliminary effects of an intervention targeting schema development for caregivers of newly admitted hospice patients.

Science.gov (United States)

Lindstrom, Kathryn B; Mazurek Melnyk, Bernadette

2013-06-01

The transition to hospice care is a stressful experience for caregivers, who report high anxiety, unpreparedness, and lack of confidence. These sequelae are likely explained by the lack of an accurate cognitive schema, not knowing what to expect or how to help their loved one. Few interventions exist for this population and most do not measure preparedness, confidence, and anxiety using a schema building a conceptual framework for a new experience. The purpose of this study was to test the feasibility and preliminary effects of an intervention program, Education and Skill building Intervention for Caregivers of Hospice patients (ESI-CH), using an innovative conceptual design that targets cognitive schema development and basic skill building for caregivers of loved ones newly admitted to hospice services. A pre-experimental one-group pre- and post-test study design was used. Eighteen caregivers caring for loved ones in their homes were recruited and twelve completed the pilot study. Depression, anxiety, activity restriction, preparedness, and beliefs/confidence were measured. Caregivers reported increased preparedness, more helpful beliefs, and more confidence about their ability to care for their loved one. Preliminary trends suggested decreased anxiety levels for the intervention group. Caregivers who completed the intervention program rated the program very good or excellent, thought the information was helpful and timely, and would recommend it to friends. Results show promise that the ESI-CH program may assist as an evidence-based program to support caregivers in their role as a caregiver to a newly admitted hospice patient.

Newly velocity field of Sulawesi Island from GPS observation

Science.gov (United States)

Sarsito, D. A.; Susilo, Simons, W. J. F.; Abidin, H. Z.; Sapiie, B.; Triyoso, W.; Andreas, H.

2017-07-01

Sulawesi microplate Island is located at famous triple junction area of the Eurasian, India-Australian, and Philippine Sea plates. Under the influence of the northward moving Australian plate and the westward motion of the Philippine plate, the island at Eastern part of Indonesia is collide and with the Eurasian plate and Sunda Block. Those recent microplate tectonic motions can be quantitatively determine by GNSS-GPS measurement. We use combine GNSS-GPS observation types (campaign type and continuous type) from 1997 to 2015 to derive newly velocity field of the area. Several strategies are applied and tested to get the optimum result, and finally we choose regional strategy to reduce error propagation contribution from global multi baseline processing using GAMIT/GLOBK 10.5. Velocity field are analyzed in global reference frame ITRF 2008 and local reference frame by fixing with respect alternatively to Eurasian plate - Sunda block, India-Australian plate and Philippine Sea plates. Newly results show dense distribution of velocity field. This information is useful for tectonic deformation studying in geospatial era.

Process control and product evaluation in micro molding using a screwless/two-plunger injection unit

DEFF Research Database (Denmark)

Tosello, Guido; Hansen, Hans Nørgaard; Dormann, B.

2010-01-01

A newly developed μ-injection molding machine equipped with a screwless/two-plunger injection unit has been employed to mould miniaturized dog-bone shaped specimens on polyoxymethylene and its process capability and robustness have been analyzed. The influence of process parameters on μ-injection......A newly developed μ-injection molding machine equipped with a screwless/two-plunger injection unit has been employed to mould miniaturized dog-bone shaped specimens on polyoxymethylene and its process capability and robustness have been analyzed. The influence of process parameters on μ......-injection molding was investigated using the Design of Experiments technique. Injection pressure and piston stroke speed as well as part weight and dimensions were considered as quality factors over a wide range of process parameters. Experimental results obtained under different processing conditions were...

Fluorescent and radiolabelling of pepsin-digested human glomerular basement membrane with a newly developed hydroxy-coumarin derivative (CASE)

International Nuclear Information System (INIS)

Rand-Weaver, M.; Abuknesha, R.A.; Price, R.G.

1985-01-01

The labelling of pepsin-digested human glomerular basement membrane (pHGBM) with a newly developed fluorescent iodine acceptor 7-hydroxy-coumarin-3-acetic acid N-hydroxysucciniimydyl ester (CASE) is described. The binding of a monoclonal antibody to pHGBM was assessed by radiobinding assays, and when directly iodinated pHGBM was used there was no apparent binding. When CASE was conjugated to pHGBM prior to iodination 11% binding was achieved. CASE acting as an iodine acceptor may be useful for proteins containing few or inaccessible tyrosine residues or which are destroyed by introduction of 125 I. Since CASE is fluorescent, small amounts of material can be detected during isolation prior to iodination. (orig.)

Experimental investigation for determination of optimal X-ray beam tube voltages in a newly developed digital breast tomosynthesis system

Energy Technology Data Exchange (ETDEWEB)

Park, Hye-Suk, E-mail: radiosugar@yonsei.ac.kr [Department of Radiological Science and Research Institute of Health Science, Yonsei University, Wonju, Gangwon 220-710 (Korea, Republic of); Kim, Ye-Seul, E-mail: radiohesugar@gmail.com [Department of Radiological Science and Research Institute of Health Science, Yonsei University, Wonju, Gangwon 220-710 (Korea, Republic of); Choi, Young-Wook, E-mail: ywchoi@keri.re.kr [Korea Electrotechnology Research Institute (KERI), Ansan, Geongki 426-170 (Korea, Republic of); Choi, JaeGu, E-mail: jgchoi88@paran.com [Korea Electrotechnology Research Institute (KERI), Ansan, Geongki 426-170 (Korea, Republic of); Rhee, Yong-Chun, E-mail: ycrhee@yonsei.ac.kr [Department of Radiological Science and Research Institute of Health Science, Yonsei University, Wonju, Gangwon 220-710 (Korea, Republic of); Kim, Hee-Joung, E-mail: hjk1@yonsei.ac.kr [Department of Radiological Science and Research Institute of Health Science, Yonsei University, Wonju, Gangwon 220-710 (Korea, Republic of)

2014-11-01

Our purpose was to investigate optimal tube voltages (kVp) for a newly developed digital breast tomosynthesis (DBT) process and to determine tube current–exposure time products (mA s) for the average glandular dose (AGD), which is similar to that of the two views in conventional mammography (CM). In addition, the optimal acquisition parameters for this system were compared with those of CM. The analysis was based on the contrast-to-noise ratio (CNR) from the simulated micro-calcifications on homogeneous phantoms, and the figure of merit (FOM) was retrieved from the CNR and AGD at X-ray tube voltages ranging from 24 to 40 kVp at intervals of 2 kV. The optimal kVp increased more than 2 kV with increasing glandularity for thicker (≥50 mm) breast phantoms. The optimal kVp for DBT was found to be 4–7 kV higher than that calculated for CM with breast phantoms thicker than 50 mm. This is likely due to the greater effect of noise and dose reduction by kVp increment when using the lower dose per projection in DBT. It is important to determine optimum acquisition conditions for a maximally effective DBT system. The results of our study provide useful information to further improve DBT for high quality imaging.

Process development for 9Cr nanostructured ferritic alloy (NFA) with high fracture toughness

International Nuclear Information System (INIS)

Byun, Thak Sang; Yoon, Ji Hyun; Hoelzer, David T.; Lee, Yong Bok; Kang, Suk Hoon; Maloy, Stuart A.

2014-01-01

This article is to summarize the process development and key characterization results for the newly-developed Fe–9Cr based nanostructured ferritic alloys (NFAs) with high fracture toughness. One of the major drawbacks from pursuing ultra-high strength in the past development of NFAs is poor fracture toughness at high temperatures although a high fracture toughness is essential to prevent cracking during manufacturing and to mitigate or delay irradiation-induced embrittlement in irradiation environments. A study on fracture mechanism using the NFA 14YWT found that the low-energy grain boundary decohesion in fracture process at a high temperature (>200 °C) resulted in low fracture toughness. Lately, efforts have been devoted to explore an integrated process to enhance grain bonding. Two base materials were produced through mechanical milling and hot extrusion and designated as 9YWTV-PM1 and 9YWTV-PM2. Isothermal annealing (IA) and controlled rolling (CR) treatments in two phase region were used to enhance diffusion across the interfaces and boundaries. The PM2 alloy after CR treatments showed high fracture toughness (K JQ ) at represented temperatures: 240–280 MPa √m at room temperature and 160–220 MPa √m at 500 °C, which indicates that the goal of 100 MPa √m over possible nuclear application temperature range has been well achieved. Furthermore, it is also confirmed by comparison that the CR treatments on 9YWTV-PM2 result in high fracture toughness similar to or higher than those of the conventional ferritic–martensitic steels such as HT9 and NF616

Critical thinking dispositions among newly graduated nurses

Science.gov (United States)

Wangensteen, Sigrid; Johansson, Inger S; Björkström, Monica E; Nordström, Gun

2010-01-01

wangensteen s., johansson i.s., björkström m.e. & nordström g. (2010) Critical thinking dispositions among newly graduated nurses. Journal of Advanced Nursing66(10), 2170–2181. Aim The aim of the study was to describe critical thinking dispositions among newly graduated nurses in Norway, and to study whether background data had any impact on critical thinking dispositions. Background Competence in critical thinking is one of the expectations of nursing education. Critical thinkers are described as well-informed, inquisitive, open-minded and orderly in complex matters. Critical thinking competence has thus been designated as an outcome for judging the quality of nursing education programmes and for the development of clinical judgement. The ability to think critically is also described as reducing the research–practice gap and fostering evidence-based nursing. Methods A cross-sectional descriptive study was performed. The data were collected between October 2006 and April 2007 using the California Critical Thinking Disposition Inventory. The response rate was 33% (n= 618). Pearson’s chi-square tests were used to analyse the data. Results Nearly 80% of the respondents reported a positive disposition towards critical thinking. The highest mean score was on the Inquisitiveness subscale and the lowest on the Truth-seeking subscale. A statistically significant higher proportion of nurses with high critical thinking scores were found among those older than 30 years, those with university education prior to nursing education, and those working in community health care. Conclusion Nurse leaders and nurse teachers should encourage and nurture critical thinking among newly graduated nurses and nursing students. The low Truth-seeking scores found may be a result of traditional teaching strategies in nursing education and might indicate a need for more student-active learning models. PMID:20384637

Status of photovoltaics in the Newly Associated States

International Nuclear Information System (INIS)

Pietruszko, S.M.; Mikolajuk, A.; Fara, L.; Fara, S.; Vitanov, P.; Stratieva, N.; Rehak, J.; Barinka, R.; Mellikov, E.; Palfy, M.; Shipkovs, P.; Krotkus, A.; Saly, V.; Nemac, F.; Swens, J.; Nowak, S.; Zachariou, A.; Fechner, H.; Passiniemi, P.

2004-01-01

The Status of Photovoltaics in the Central and Eastern Europe presents the state of the art of photovoltaics (PV) in the Newly Associated States (NAS): Bulgaria, the Czech Republic, Estonia, Hungary, Latvia, Lithuania, Poland, Romania, Slovakia, Slovenia. The attempt was made to cover all photovoltaics activities in NAS, from research to industry and markets as well as from technology development to dissemination and education. The document covers the following topics and issues: organization of PV research and demonstration activities, stakeholders involved in research and technology development (RTD), scientific potential of NAS PV community, PV activities carried out in NAS countries, PV policies and support mechanisms, achievements and barriers, challenges and needs to the development of PV in the NAS. (authors)

The Activity of Carbohydrate-Degrading Enzymes in the Development of Brood and Newly Emerged workers and Drones of the Carniolan Honeybee, Apis mellifera carnica

OpenAIRE

Żółtowska, Krystyna; Lipiński, Zbigniew; Łopieńska-Biernat, Elżbieta; Farjan, Marek; Dmitryjuk, Małgorzata

2012-01-01

The activity of glycogen Phosphorylase and carbohydrate hydrolyzing enzymes α-amylase, glucoamylase, trehalase, and sucrase was studied in the development of the Carniolan honey bee, Apis mellifera carnica Pollman (Hymenoptera: Apidae), from newly hatched larva to freshly emerged imago of worker and drone. Phosphorolytic degradation of glycogen was significantly stronger than hydrolytic degradation in all developmental stages. Developmental profiles of hydrolase activity were similar in both ...

Three-dimensional quantification of cardiac surface motion: a newly developed three-dimensional digital motion-capture and reconstruction system for beating heart surgery.

Science.gov (United States)

Watanabe, Toshiki; Omata, Sadao; Odamura, Motoki; Okada, Masahumi; Nakamura, Yoshihiko; Yokoyama, Hitoshi

2006-11-01

This study aimed to evaluate our newly developed 3-dimensional digital motion-capture and reconstruction system in an animal experiment setting and to characterize quantitatively the three regional cardiac surface motions, in the left anterior descending artery, right coronary artery, and left circumflex artery, before and after stabilization using a stabilizer. Six pigs underwent a full sternotomy. Three tiny metallic markers (diameter 2 mm) coated with a reflective material were attached on three regional cardiac surfaces (left anterior descending, right coronary, and left circumflex coronary artery regions). These markers were captured by two high-speed digital video cameras (955 frames per second) as 2-dimensional coordinates and reconstructed to 3-dimensional data points (about 480 xyz-position data per second) by a newly developed computer program. The remaining motion after stabilization ranged from 0.4 to 1.01 mm at the left anterior descending, 0.91 to 1.52 mm at the right coronary artery, and 0.53 to 1.14 mm at the left circumflex regions. Significant differences before and after stabilization were evaluated in maximum moving velocity (left anterior descending 456.7 +/- 178.7 vs 306.5 +/- 207.4 mm/s; right coronary artery 574.9 +/- 161.7 vs 446.9 +/- 170.7 mm/s; left circumflex 578.7 +/- 226.7 vs 398.9 +/- 192.6 mm/s; P heart surface movement. This helps us better understand the complexity of the heart, its motion, and the need for developing a better stabilizer for beating heart surgery.

Technical cost modelling for a novel semi-solid metal (SSM) casting processes for automotive component manufacturing

CSIR Research Space (South Africa)

Tlale, NS

2008-09-01

Full Text Available to predict the cost structure of a newly developed manufacturing process if it is to be considered by manufacturing enterprises for development to substitute a process that is in use. The costs of the new SSM technologies was established by technical cost...

Identification of Newly Synthesized Proteins by Echinococcus granulosus Protoscoleces upon Induction of Strobilation.

Directory of Open Access Journals (Sweden)

João Antonio Debarba

2015-09-01

Full Text Available The proteins responsible for the key molecular events leading to the structural changes between the developmental stages of Echinococcus granulosus remain unknown. In this work, azidohomoalanine (AHA-specific labeling was used to identify proteins expressed by E. granulosus protoscoleces (PSCs upon the induction of strobilar development.The in vitro incorporation of AHA with different tags into newly synthesized proteins (NSPs by PSCs was analyzed using SDS-PAGE and confocal microscopy. The LC-MS/MS analysis of AHA-labeled NSPs by PSCs undergoing strobilation allowed for the identification of 365 proteins, of which 75 were differentially expressed in comparison between the presence or absence of strobilation stimuli and 51 were expressed exclusively in either condition. These proteins were mainly involved in metabolic, regulatory and signaling processes.After the controlled-labeling of proteins during the induction of strobilar development, we identified modifications in protein expression. The changes in the metabolism and the activation of control and signaling pathways may be important for the correct parasite development and be target for further studies.

Orbit Correction for the Newly Developed Polarization-Switching Undulator

Science.gov (United States)

Obina, Takashi; Honda, Tohru; Shioya, Tatsuro; Kobayashi, Yukinori; Tsuchiya, Kimichika; Yamamoto, Shigeru

2007-01-01

A new scheme of undulator magnet arrangements has been proposed and developed as a polarization-switching radiation source, and its test-stand was installed in the 2.5-GeV Photon Factory storage ring (PF ring) in order to investigate the effects on the beam orbit. The closed orbit distortion (COD) over 200 μm was produced in a vertical direction when we switched the polarization of the radiation from the test-stand. In a horizontal direction, the COD was less than 50μm. The results agreed well with the predictions from the magnetic-field measurement on the bench. In order to suppress the CODs and realize a stable operation of the ring with the polarization-switching, we developed an orbit correction system which consists of an encoder to detect motion of magnets, a pair of beam position monitors (BPMs), signal processing parts, and a pair of steering magnets. We succeeded in suppressing the CODs to the level below 3μm using the system even when we switch the polarization at a maximum frequency of 0.8 Hz.

RELATIONSHIP BETWEEN DIFFERENT ALLOGAMIC ASSOCIATED TRAIT CHARACTERISTICS OF THE FIVE NEWLY DEVELOPED CYTOPLASMIC MALE STERILE (CMS LINES IN RICE

Directory of Open Access Journals (Sweden)

Nematzadeh GHORBAN ALI

2006-10-01

Full Text Available Five suitable maintainer varieties were identifi ed through testcrosses with IR58025A and the transfer of wild abortive cytoplasm was carried out by seven successive backcrosses. Five new CMS lines were developed by this approach in well adapted high yielding improved varietal background such as ‘Nemat’, ‘Neda’, ‘Dasht’, ‘Amol3’ and ‘Champa’. Agronomical characterization and allogamy-associated traits of the fi ve newly developed CMS lines were studied for their interrelationship. Anther length had a signifi cant positive correlation with the duration of glume opening (0.759 and high correlation of (0.698 with the angle between lemma and palea. The results indicated that ‘Nemat’ A, ‘Neda’ A, ‘Dasht’ A are more suitable as parents for hybrid seed production due to their favorable and superior fl oral characteristics in comparison to IR58025A.

The processes of strategy development

OpenAIRE

Bailey, Andy; Johnson, Gerry

1995-01-01

This paper is concerned with the processes by which strategy is developed within organisations. It builds on research into the nature of strategy development being undertaken within the Centre for Strategic Management and Organisational Change at Cranfield School of Management. Initially the process of strategy development is discussed, a number of explanations of the process are presented and an integrated framework is developed. This framework is subsequently used to illustra...

Development of Food Preservation and Processing Technologies by Radiation Technology

International Nuclear Information System (INIS)

Byun, Myung Woo; Lee, Ju Won; Kim, Jae Hun

2007-07-01

To secure national food resources, development of energy-saving food processing and preservation technologies, establishment of method on improvement of national health and safety by development of alternative techniques of chemicals and foundation of the production of hygienic food and public health related products by irradiation technology were studied. Results at current stage are following: As the first cooperative venture business technically invested by National Atomic Research Development Project, institute/company's [technology-invested technology foundation No. 1] cooperative venture, Sun-BioTech Ltd., was founded and stated its business. This suggested new model for commercialization and industrialization of the research product by nation-found institute. From the notice of newly approved product list about irradiated food, radiation health related legal approval on 7 food items was achieved from the Ministry of health and wellfare, the Korea Food and Drug Administration, and this contributed the foundation of enlargement of practical use of irradiated food. As one of the foundation project for activation of radiation application technology for the sanitation and secure preservation of special food, such as military meal service, food service for patient, and food for sports, and instant food, such as ready-to-eat/ready-to-cook food, the proposal for radiation application to the major military commander at the Ministry of National Defence and the Joint Chiefs of Staff was accepted for the direction of military supply development in mid-termed plan for the development of war supply. Especially, through the preliminary research and the development of foundation technology for the development of the Korean style space food and functional space food, space Kimch with very long shelf life was finally developed. The development of new item/products for food and life science by combining RT/BT, the development of technology for the elimination/reduction of

Development of Food Preservation and Processing Technologies by Radiation Technology

Energy Technology Data Exchange (ETDEWEB)

Byun, Myung Woo; Lee, Ju Won; Kim, Jae Hun [and others

2007-07-15

To secure national food resources, development of energy-saving food processing and preservation technologies, establishment of method on improvement of national health and safety by development of alternative techniques of chemicals and foundation of the production of hygienic food and public health related products by irradiation technology were studied. Results at current stage are following: As the first cooperative venture business technically invested by National Atomic Research Development Project, institute/company's [technology-invested technology foundation No. 1] cooperative venture, Sun-BioTech Ltd., was founded and stated its business. This suggested new model for commercialization and industrialization of the research product by nation-found institute. From the notice of newly approved product list about irradiated food, radiation health related legal approval on 7 food items was achieved from the Ministry of health and wellfare, the Korea Food and Drug Administration, and this contributed the foundation of enlargement of practical use of irradiated food. As one of the foundation project for activation of radiation application technology for the sanitation and secure preservation of special food, such as military meal service, food service for patient, and food for sports, and instant food, such as ready-to-eat/ready-to-cook food, the proposal for radiation application to the major military commander at the Ministry of National Defence and the Joint Chiefs of Staff was accepted for the direction of military supply development in mid-termed plan for the development of war supply. Especially, through the preliminary research and the development of foundation technology for the development of the Korean style space food and functional space food, space Kimch with very long shelf life was finally developed. The development of new item/products for food and life science by combining RT/BT, the development of technology for the elimination/reduction of

Development of Food Preservation and Processing Technologies by Radiation Technology

Energy Technology Data Exchange (ETDEWEB)

Byun, Myung Woo; Lee, Ju Won; Kim, Jae Hun (and others)

2007-07-15

To secure national food resources, development of energy-saving food processing and preservation technologies, establishment of method on improvement of national health and safety by development of alternative techniques of chemicals and foundation of the production of hygienic food and public health related products by irradiation technology were studied. Results at current stage are following: As the first cooperative venture business technically invested by National Atomic Research Development Project, institute/company's [technology-invested technology foundation No. 1] cooperative venture, Sun-BioTech Ltd., was founded and stated its business. This suggested new model for commercialization and industrialization of the research product by nation-found institute. From the notice of newly approved product list about irradiated food, radiation health related legal approval on 7 food items was achieved from the Ministry of health and wellfare, the Korea Food and Drug Administration, and this contributed the foundation of enlargement of practical use of irradiated food. As one of the foundation project for activation of radiation application technology for the sanitation and secure preservation of special food, such as military meal service, food service for patient, and food for sports, and instant food, such as ready-to-eat/ready-to-cook food, the proposal for radiation application to the major military commander at the Ministry of National Defence and the Joint Chiefs of Staff was accepted for the direction of military supply development in mid-termed plan for the development of war supply. Especially, through the preliminary research and the development of foundation technology for the development of the Korean style space food and functional space food, space Kimch with very long shelf life was finally developed. The development of new item/products for food and life science by combining RT/BT, the development of technology for the elimination/reduction of

Clinical Prediction Model for Time in Therapeutic Range While on Warfarin in Newly Diagnosed Atrial Fibrillation.

Science.gov (United States)

Williams, Brent A; Evans, Michael A; Honushefsky, Ashley M; Berger, Peter B

2017-10-12

Though warfarin has historically been the primary oral anticoagulant for stroke prevention in newly diagnosed atrial fibrillation (AF), several new direct oral anticoagulants may be preferred when anticoagulation control with warfarin is expected to be poor. This study developed a prediction model for time in therapeutic range (TTR) among newly diagnosed AF patients on newly initiated warfarin as a tool to assist decision making between warfarin and direct oral anticoagulants. This electronic medical record-based, retrospective study included newly diagnosed, nonvalvular AF patients with no recent warfarin exposure receiving primary care services through a large healthcare system in rural Pennsylvania. TTR was estimated as the percentage of time international normalized ratio measurements were between 2.0 and 3.0 during the first year following warfarin initiation. Candidate predictors of TTR were chosen from data elements collected during usual clinical care. A TTR prediction model was developed and temporally validated and its predictive performance was compared with the SAMe-TT 2 R 2 score (sex, age, medical history, treatment, tobacco, race) using R 2 and c-statistics. A total of 7877 newly diagnosed AF patients met study inclusion criteria. Median (interquartile range) TTR within the first year of starting warfarin was 51% (32, 67). Of 85 candidate predictors evaluated, 15 were included in the final validated model with an R 2 of 15.4%. The proposed model showed better predictive performance than the SAMe-TT 2 R 2 score ( R 2 =3.0%). The proposed prediction model may assist decision making on the proper mode of oral anticoagulant among newly diagnosed AF patients. However, predicting TTR on warfarin remains challenging. © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

The activity of carbohydrate-degrading enzymes in the development of brood and newly emerged workers and drones of the Carniolan honeybee, Apis mellifera carnica.

Science.gov (United States)

Żółtowska, Krystyna; Lipiński, Zbigniew; Łopieńska-Biernat, Elżbieta; Farjan, Marek; Dmitryjuk, Małgorzata

2012-01-01

The activity of glycogen Phosphorylase and carbohydrate hydrolyzing enzymes α-amylase, glucoamylase, trehalase, and sucrase was studied in the development of the Carniolan honey bee, Apis mellifera carnica Pollman (Hymenoptera: Apidae), from newly hatched larva to freshly emerged imago of worker and drone. Phosphorolytic degradation of glycogen was significantly stronger than hydrolytic degradation in all developmental stages. Developmental profiles of hydrolase activity were similar in both sexes of brood; high activity was found in unsealed larvae, the lowest in prepupae followed by an increase in enzymatic activity. Especially intensive increases in activity occurred in the last stage of pupae and newly emerged imago. Besides α-amylase, the activities of other enzymes were higher in drone than in worker broods. Among drones, activity of glucoamylase was particularly high, ranging from around three times higher in the youngest larvae to 13 times higher in the oldest pupae. This confirms earlier suggestions about higher rates of metabolism in drone broods than in worker broods.

Confidence in leadership among the newly qualified.

Science.gov (United States)

Bayliss-Pratt, Lisa; Morley, Mary; Bagley, Liz; Alderson, Steven

2013-10-23

The Francis report highlighted the importance of strong leadership from health professionals but it is unclear how prepared those who are newly qualified feel to take on a leadership role. We aimed to assess the confidence of newly qualified health professionals working in the West Midlands in the different competencies of the NHS Leadership Framework. Most respondents felt confident in their abilities to demonstrate personal qualities and work with others, but less so at managing or improving services or setting direction.

PSE in Pharmaceutical Process Development

DEFF Research Database (Denmark)

Gernaey, Krist; Cervera Padrell, Albert Emili; Woodley, John

2011-01-01

The pharmaceutical industry is under growing pressure to increase efficiency, both in production and in process development. This paper will discuss the use of Process Systems Engineering (PSE) methods in pharmaceutical process development, and searches for answers to questions such as: Which PSE...

Phenology of Lymantria monacha (Lepidoptera:Lymantriidae) laboratory reared on spruce foliage or a newly developed artificial diet

Science.gov (United States)

Melody A. Keena; Alice Vandel; Oldrich. Pultar

2010-01-01

Lymantria monacha (L.) (Lepidoptera: Lymantriidae) is a Eurasian pest of conifers that has potential for accidental introduction into North America. The phenology over the entire life cycle for L. monacha individuals from the Czech Republic was compared on Picea glauca (Moench) Voss (white spruce) and a newly...

Problems faced by newly diagnosed diabetes mellitus patients at ...

African Journals Online (AJOL)

Diabetes mellitus can be a frightening experience for newly diagnosed patients. The aim of this study was to determine and describe the problems faced by newly diagnosed diabetes mellitus patients at primary healthcare facilities at Mopani district, Limpopo Province. A qualitative, descriptive and contextual research ...

Assessment by Employers of Newly Graduated Civil Engineers from the Islamic University of Gaza

Science.gov (United States)

Enshassi, Adnan; Hassouna, Ahmed

2005-01-01

The evaluation process is very important to identify and recognize the strengths and the weaknesses of graduated students. The purpose of this paper is to evaluate the performance of the newly graduated civil engineers from the Islamic University of Gaza in Palestine. The methodology was based on questionnaires and informal interview. The…

Newly graduated nurses' use of knowledge sources in clinical decision-making

DEFF Research Database (Denmark)

Voldbjerg, Siri Lygum; Grønkjaer, Mette; Wiechula, Rick

2017-01-01

AIMS AND OBJECTIVES: To explore which knowledge sources newly graduated nurses' use in clinical decision-making and why and how they are used. BACKGROUND: In spite of an increased educational focus on skills and competencies within evidence based practice newly graduated nurses' ability to use...... approaches to strengthen the knowledgebase used in clinical decision-making. DESIGN AND METHODS: Ethnographic study using participant-observation and individual semi-structured interviews of nine Danish newly graduated nurses in medical and surgical hospital settings. RESULTS: Newly graduates use...... in clinical decision-making. If newly graduates are to be supported in an articulate and reflective use of a variety of sources, they have to be allocated to experienced nurses who model a reflective, articulate and balanced use of knowledge sources. This article is protected by copyright. All rights reserved....

Newly graduated nurses' occupational commitment and its associations with professional competence and work-related factors.

Science.gov (United States)

Numminen, Olivia; Leino-Kilpi, Helena; Isoaho, Hannu; Meretoja, Riitta

2016-01-01

To explore newly graduated nurses' occupational commitment and its associations with their self-assessed professional competence and other work-related factors. As a factor affecting nurse turnover, newly graduated nurses' occupational commitment and its associations with work-related factors needs exploring to retain adequate workforce. Nurses' commitment has mainly been studied as organisational commitment, but newly graduated nurses' occupational commitment and its association with work-related factors needs further studying. This study used descriptive, cross-sectional, correlation design. A convenience sample of 318 newly graduated nurses in Finland participated responding to an electronic questionnaire. Statistical software, NCSS version 9, was used in data analysis. Frequencies, percentages, ranges, means and standard deviations summarised the data. Multivariate Analyses of Variance estimated associations between occupational commitment and work-related variables. IBM SPSS Amos version 22 estimated the model fit of Occupational Commitment Scale and Nurse Competence Scale. Newly graduated nurses' occupational commitment was good, affective commitment reaching the highest mean score. There was a significant difference between the nurse groups in favour of nurses at higher competence levels in all subscales except in limited alternatives occupational commitment. Multivariate analyses revealed significant associations between subscales of commitment and competence, turnover intentions, job satisfaction, earlier professional education and work sector, competence counting only through affective dimension. The association between occupational commitment and low turnover intentions and satisfaction with nursing occupation was strong. Higher general competence indicated higher overall occupational commitment. Managers' recognition of the influence of all dimensions of occupational commitment in newly graduated nurses' professional development is important. Follow

Ethical climate and nurse competence - newly graduated nurses' perceptions.

Science.gov (United States)

Numminen, Olivia; Leino-Kilpi, Helena; Isoaho, Hannu; Meretoja, Riitta

2015-12-01

is also a need for knowledge of newly graduated nurses' views of factors which act as enhancers or barriers to positive ethical climates to develop. Interventions, continuing education courses, and discussions designed to promote positive ethical climates should be developed for managers, nurses, and multi-professional teams. © The Author(s) 2014.

Practices influenced by policy? An exploration of newly hired science teachers at sites in South Africa and the United States

Science.gov (United States)

Navy, S. L.; Luft, J. A.; Toerien, R.; Hewson, P. W.

2018-05-01

In many parts of the world, newly hired science teachers' practices are developing in a complex policy environment. However, little is known about how newly hired science teachers' practices are enacted throughout a cycle of instruction and how these practices can be influenced by macro-, meso-, and micro-policies. Knowing how policies impact practice can result in better policies or better support for certain policies in order to enhance the instruction of newly hired teachers. This comparative study investigated how 12 newly hired science teachers at sites in South Africa (SA) and the United States (US) progressed through an instructional cycle of planning, teaching, and reflection. The qualitative data were analysed through beginning teacher competency frameworks, the cycle of instruction, and institutional theory. Data analysis revealed prevailing areas of practice and connections to levels of policy within the instructional cycle phases. There were some differences between the SA and US teachers and among first-, second-, and third-year teachers. More importantly, this study indicates that newly hired teachers are susceptible to micro-policies and are progressively developing their practice. It also shows the importance of meso-level connectors. It suggests that teacher educators and policy makers must consider how to prepare and support newly hired science teachers to achieve the shared global visions of science teaching.

High-Throughput Process Development for Biopharmaceuticals.

Science.gov (United States)

Shukla, Abhinav A; Rameez, Shahid; Wolfe, Leslie S; Oien, Nathan

2017-11-14

The ability to conduct multiple experiments in parallel significantly reduces the time that it takes to develop a manufacturing process for a biopharmaceutical. This is particularly significant before clinical entry, because process development and manufacturing are on the "critical path" for a drug candidate to enter clinical development. High-throughput process development (HTPD) methodologies can be similarly impactful during late-stage development, both for developing the final commercial process as well as for process characterization and scale-down validation activities that form a key component of the licensure filing package. This review examines the current state of the art for HTPD methodologies as they apply to cell culture, downstream purification, and analytical techniques. In addition, we provide a vision of how HTPD activities across all of these spaces can integrate to create a rapid process development engine that can accelerate biopharmaceutical drug development. Graphical Abstract.

Efficacy of Intra-articular Injection of a Newly Developed Plasma Rich in Growth Factor (PRGF) Versus Hyaluronic Acid on Pain and Function of Patients with Knee Osteoarthritis: A Single-Blinded Randomized Clinical Trial.

Science.gov (United States)

Raeissadat, Seyed Ahmad; Rayegani, Seyed Mansoor; Ahangar, Azadeh Gharooee; Abadi, Porya Hassan; Mojgani, Parviz; Ahangar, Omid Gharooi

2017-01-01

Knee osteoarthritis is the most common joint disease. We aimed to compare the efficacy and safety of intra-articular injection of a newly developed plasma rich in growth factor (PRGF) versus hyaluronic acid (HA) on pain and function of patients with knee osteoarthritis. In this single-blinded randomized clinical trial, patients with symptomatic osteoarthritis of knee were assigned to receive 2 intra-articular injections of our newly developed PRGF in 3 weeks or 3 weekly injections of HA. Our primary outcome was the mean change from baseline until 2 and 6 months post intervention in scores of visual analog scale, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Lequesne index. We used analysis of variance for repeated-measures statistical test. A total of 69 patients entered final analysis. The mean age of patients was 58.2 ± 7.41 years and 81.2% were women. In particular, total WOMAC index decreased from 42.9 ± 13.51 to 26.8 ± 13.45 and 24.4 ± 16.54 at 2 and 6 months in the newly developed PRGF group (within subjects P  = .001), and from 38.8 ± 12.62 to 27.8 ± 11.01 and 27.4 ± 11.38 at 2 and 6 months in the HA group (within subjects P  = .001), respectively (between subjects P  = .631). There was no significant difference between PRGF and HA groups in patients' satisfaction and minor complications of injection, whereas patients in HA group reported significantly lower injection-induced pain. In 6 months follow up, our newly developed PRGF and HA, both are effective options to decrease pain and improvement of function in patients with symptomatic mild to moderate knee osteoarthritis.

[Bioethical analysis of the use of newly dead patients in medical learning].

Science.gov (United States)

Gomes, Andréia Patrícia; Rego, Sergio; Palácios, Marisa; Siqueira-Batista, Rodrigo

2010-01-01

The purpose of this article is to carry out, a discussion on the subject of bioethics and cadavers based upon a critic review of literature. A review of literature, was made with a survey of articles between 1977 and 2007 in the sites 'Biblioteca Virtual de Saúde', PubMed and SciElo, utilizing the keywords: newly deceased patients, newly dead patients, simulators,. This was complemented by a critical evaluation of books published in the area of ethics and bioethics. The possibility to develop learning without orientation by a supervisor is doubtful.. The utilization of newly dead for learning invasive procedures is very frequent and seldom admitted. These procedures, are usually, carried out secretly, without the knowledge and consent of the family. The ethical aspects of these practices are not discussed in the practical medical education. It essential that the ethics of use of recent deceased become a necessary content of graduate education. Performance of these procedures by students should always be authorized by family members. The simulators meet the requirements of training. Discussions about the ethical and bioethical aspects cannot be separated from practical considerations during the students learning time.

Scandinavian exceptionalism? Civic integration and labour market activation for newly arrived immigrants.

Science.gov (United States)

Breidahl, Karen N

2017-01-01

Since the late 1990s, a wide range of so-called new civic integration policies aimed at civilizing or disciplining newcomers have been introduced. Consequently, migration scholars have discussed whether a converging restrictive 'civic turn' has taken place in Western Europe or whether national models have been resilient: Based on an in-depth historical and comparative analysis of labour market activation policies targeting newly arrived immigrants in Sweden, Norway, and Denmark since the early 1990s, the article contributes to the overall question: To what extent do the institutional pathways of the Scandinavian welfare states prevail when confronted with newcomers? Activation policies targeting newly arrived immigrants exemplifies how the ambition of states to promote functional, individual autonomy is also an important, ongoing process in diverse policy areas of the welfare state and not restricted to early integration instruments. While the Scandinavian welfare states differ on a number of counts with respect to immigration control, national integration philosophies and citizenship policies, the article outlines how activation policies aimed at newly arrived immigrants share several features. One of the key factors in this turn involves path dependency from, among others, a lengthy tradition for strong state involvement and norms about employment. Another factor in this turn involves transnational policy learning. On some points, national versions of these policies are also found due to country-specific citizenship traditions, integration philosophies and party political constellations.

Demonstration of glucose-6-phosphate dehydrogenase in rat Kupffer cells by a newly-developed ultrastructural enzyme-cytochemistry

Directory of Open Access Journals (Sweden)

S Matsubara

2009-06-01

Full Text Available Although various tissue macrophages possess high glucose- 6-phosphate dehydrogenase (G6PD activity, which is reported to be closely associated with their phagocytotic/bactericidal function, the fine subcellular localization of this enzyme in liver resident macrophages (Kupffer cells has not been determined.We have investigated the subcellular localization of G6PD in Kupffer cells in rat liver, using a newly developed enzyme-cytochemical (copper-ferrocyanide method. Electron-dense precipitates indicating G6PD activity were clearly visible in the cytoplasm and on the cytosolic side of the endoplasmic reticulum of Kupffer cells. Cytochemical controls ensured specific detection of the enzymatic activity. Rat Kupffer cells abundantly possessed enzyme-cytochemically detectable G6PD activity. Kupffer cell G6PD may play a role in liver defense by delivering NADPH to NADPH-dependent enzymes. G6PD enzyme-cytochemistry may be a useful tool for the study of Kupffer cell functions.

10-GHz return-to-zero pulse source tunable in wavelength with a single- or multiwavelength output based on four-wave mixing in a newly developed highly nonlinear fiber

DEFF Research Database (Denmark)

Clausen, A. T.; Oxenlowe, L.; Peucheret, Christophe

2001-01-01

In this letter, a novel scheme for a wavelength-tunable pulse source (WTPS) is proposed and characterized. It is based on four-wave mixing (FWM) in a newly developed highly nonlinear fiber between a return-to-zero (RZ) pulsed signal at a fixed wavelength and a continuous wave probe tunable...

Shared decision making in the management of children with newly diagnosed immune thrombocytopenia.

Science.gov (United States)

Beck, Carolyn E; Boydell, Katherine M; Stasiulis, Elaine; Blanchette, Victor S; Llewellyn-Thomas, Hilary; Birken, Catherine S; Breakey, Vicky R; Parkin, Patricia C

2014-10-01

This study aimed to examine the treatment decision-making process for children hospitalized with newly diagnosed immune thrombocytopenia (ITP). Using focus groups, we studied children with ITP, parents of children with ITP, and health care professionals, inquiring about participants' experience with decision support and decision making in newly diagnosed ITP. Data were examined using thematic analysis. Themes that emerged from children were feelings of "anxiety, fear, and confusion"; the need to "understand information"; and "treatment choice," the experience of which was age dependent. For parents, "anxiety, fear, and confusion" was a dominant theme; "treatment choice" revealed that participants felt directed toward intravenous immune globulin (IVIG) for initial treatment. For health care professionals, "comfort level" highlighted factors contributing to professionals' comfort with offering options; "assumptions" were made about parental desire for participation in shared decision making (SDM) and parental acceptance of treatment options; "providing information" was informative regarding modes of facilitating SDM; and "treatment choice" revealed a discrepancy between current practice (directed toward IVIG) and the ideal of SDM. At our center, families of children with newly diagnosed ITP are not experiencing SDM. Our findings support the implementation of SDM to facilitate patient-centered care for the management of pediatric ITP.

Optimization of a novel enzyme treatment process for early-stage processing of sheepskins.

Science.gov (United States)

Lim, Y F; Bronlund, J E; Allsop, T F; Shilton, A N; Edmonds, R L

2010-01-01

An enzyme treatment process for early-stage processing of sheepskins has been previously reported by the Leather and Shoe Research Association of New Zealand (LASRA) as an alternative to current industry operations. The newly developed process had marked benefits over conventional processing in terms of a lowered energy usage (73%), processing time (47%) as well as water use (49%), but had been developed as a "proof of principle''. The objective of this work was to develop the process further to a stage ready for adoption by industry. Mass balancing was used to investigate potential modifications for the process based on the understanding developed from a detailed analysis of preliminary design trials. Results showed that a configuration utilising a 2 stage counter-current system for the washing stages and segregation and recycling of enzyme float prior to dilution in the neutralization stage was a significant improvement. Benefits over conventional processing include a reduction of residual TDS by 50% at the washing stages and 70% savings on water use overall. Benefits over the un-optimized LASRA process are reduction of solids in product after enzyme treatment and neutralization stages by 30%, additional water savings of 21%, as well as 10% savings of enzyme usage.

PREVALENCE OF SLEEP DISORDERED BREATHING IN PATIENTS WITH NEWLY DIAGNOSED ACROMEGALY

Directory of Open Access Journals (Sweden)

U. A. Tsoy

2014-01-01

Full Text Available Background: Obstructive sleep disordered breathing or obstructive sleep apnea (OSA is the most common respiratory impairment in acromegaly. OSA is bound up with heightened cardiovascular mortality. Aim: Тo study frequency, features, and structure of sleep disordered breathing in patients with newly diagnosed acromegaly and to elucidate the factors influencing their development. Materials and methods: 38 patients (10 men, 28 women, median age 53 (28-76 years, median body mass index (BMI 29 (19.9-44.3 kg/m² with newly diagnosed acromegaly were recruited into the study. All subjects underwent full polysomnography (Embla N7000, Natus, USA and Remlogica software (USA. Results: Sleep disordered breathing was found in 28 (73.7% patients. OSA was revealed in all cases, in 11 (39.3% subjects it was mixed. In 10 (35.7% patients OSA was mild, in 8 (28.6% moderate, and in 10 (35.7% severe. BMI (р<0.01, disease duration (р=0.003, and insulin-like growth factor-1 (IGF-1 level (р=0.04 were different in patients without OSA and patients with moderate-to-severe OSA. No difference was found in sex (р=0.4, age (р=0.064, and growth hormone level (р=0.6. Frequency of arterial hypertension, diabetes mellitus, and other glucose metabolism impairments was the same in subjects without OSA and with severe-to-moderate OSA. Conclusion: All patients with newly diagnosed acromegaly should undergo polysomnography. BMI, disease duration, and IGF-1 level are significant risk factors for OSA development. Correlation OSA with arterial hypertension and glucose metabolism impairments needs to be further investigated.

Application of a newly developed software program for image quality assessment in cone-beam computed tomography.

Science.gov (United States)

de Oliveira, Marcus Vinicius Linhares; Santos, António Carvalho; Paulo, Graciano; Campos, Paulo Sergio Flores; Santos, Joana

2017-06-01

The purpose of this study was to apply a newly developed free software program, at low cost and with minimal time, to evaluate the quality of dental and maxillofacial cone-beam computed tomography (CBCT) images. A polymethyl methacrylate (PMMA) phantom, CQP-IFBA, was scanned in 3 CBCT units with 7 protocols. A macro program was developed, using the free software ImageJ, to automatically evaluate the image quality parameters. The image quality evaluation was based on 8 parameters: uniformity, the signal-to-noise ratio (SNR), noise, the contrast-to-noise ratio (CNR), spatial resolution, the artifact index, geometric accuracy, and low-contrast resolution. The image uniformity and noise depended on the protocol that was applied. Regarding the CNR, high-density structures were more sensitive to the effect of scanning parameters. There were no significant differences between SNR and CNR in centered and peripheral objects. The geometric accuracy assessment showed that all the distance measurements were lower than the real values. Low-contrast resolution was influenced by the scanning parameters, and the 1-mm rod present in the phantom was not depicted in any of the 3 CBCT units. Smaller voxel sizes presented higher spatial resolution. There were no significant differences among the protocols regarding artifact presence. This software package provided a fast, low-cost, and feasible method for the evaluation of image quality parameters in CBCT.

Application of a newly developed software program for image quality assessment in cone-beam computed tomography

International Nuclear Information System (INIS)

De Oliveira, Marcus Vinicius Linhares; Campos, Paulo Sergio Flores; Paulo, Graciano; Santos, Antonio Carvalho; Santos, Joana

2017-01-01

The purpose of this study was to apply a newly developed free software program, at low cost and with minimal time, to evaluate the quality of dental and maxillofacial cone-beam computed tomography (CBCT) images. A polymethyl methacrylate (PMMA) phantom, CQP-IFBA, was scanned in 3 CBCT units with 7 protocols. A macro program was developed, using the free software ImageJ, to automatically evaluate the image quality parameters. The image quality evaluation was based on 8 parameters: uniformity, the signal-to-noise ratio (SNR), noise, the contrast-to-noise ratio (CNR), spatial resolution, the artifact index, geometric accuracy, and low-contrast resolution. The image uniformity and noise depended on the protocol that was applied. Regarding the CNR, high-density structures were more sensitive to the effect of scanning parameters. There were no significant differences between SNR and CNR in centered and peripheral objects. The geometric accuracy assessment showed that all the distance measurements were lower than the real values. Low-contrast resolution was influenced by the scanning parameters, and the 1-mm rod present in the phantom was not depicted in any of the 3 CBCT units. Smaller voxel sizes presented higher spatial resolution. There were no significant differences among the protocols regarding artifact presence. This software package provided a fast, low-cost, and feasible method for the evaluation of image quality parameters in CBCT

Application of a newly developed software program for image quality assessment in cone-beam computed tomography

Energy Technology Data Exchange (ETDEWEB)

De Oliveira, Marcus Vinicius Linhares; Campos, Paulo Sergio Flores [Federal Institute of Bahia, Salvador (Brazil); Paulo, Graciano; Santos, Antonio Carvalho; Santos, Joana [Coimbra Health School, Polytechnic Institute of Coimbra, Coimbra (Portugal)

2017-06-15

The purpose of this study was to apply a newly developed free software program, at low cost and with minimal time, to evaluate the quality of dental and maxillofacial cone-beam computed tomography (CBCT) images. A polymethyl methacrylate (PMMA) phantom, CQP-IFBA, was scanned in 3 CBCT units with 7 protocols. A macro program was developed, using the free software ImageJ, to automatically evaluate the image quality parameters. The image quality evaluation was based on 8 parameters: uniformity, the signal-to-noise ratio (SNR), noise, the contrast-to-noise ratio (CNR), spatial resolution, the artifact index, geometric accuracy, and low-contrast resolution. The image uniformity and noise depended on the protocol that was applied. Regarding the CNR, high-density structures were more sensitive to the effect of scanning parameters. There were no significant differences between SNR and CNR in centered and peripheral objects. The geometric accuracy assessment showed that all the distance measurements were lower than the real values. Low-contrast resolution was influenced by the scanning parameters, and the 1-mm rod present in the phantom was not depicted in any of the 3 CBCT units. Smaller voxel sizes presented higher spatial resolution. There were no significant differences among the protocols regarding artifact presence. This software package provided a fast, low-cost, and feasible method for the evaluation of image quality parameters in CBCT.

Patient/Family Education for Newly Diagnosed Pediatric Oncology Patients.

Science.gov (United States)

Landier, Wendy; Ahern, JoAnn; Barakat, Lamia P; Bhatia, Smita; Bingen, Kristin M; Bondurant, Patricia G; Cohn, Susan L; Dobrozsi, Sarah K; Haugen, Maureen; Herring, Ruth Anne; Hooke, Mary C; Martin, Melissa; Murphy, Kathryn; Newman, Amy R; Rodgers, Cheryl C; Ruccione, Kathleen S; Sullivan, Jeneane; Weiss, Marianne; Withycombe, Janice; Yasui, Lise; Hockenberry, Marilyn

There is a paucity of data to support evidence-based practices in the provision of patient/family education in the context of a new childhood cancer diagnosis. Since the majority of children with cancer are treated on pediatric oncology clinical trials, lack of effective patient/family education has the potential to negatively affect both patient and clinical trial outcomes. The Children's Oncology Group Nursing Discipline convened an interprofessional expert panel from within and beyond pediatric oncology to review available and emerging evidence and develop expert consensus recommendations regarding harmonization of patient/family education practices for newly diagnosed pediatric oncology patients across institutions. Five broad principles, with associated recommendations, were identified by the panel, including recognition that (1) in pediatric oncology, patient/family education is family-centered; (2) a diagnosis of childhood cancer is overwhelming and the family needs time to process the diagnosis and develop a plan for managing ongoing life demands before they can successfully learn to care for the child; (3) patient/family education should be an interprofessional endeavor with 3 key areas of focus: (a) diagnosis/treatment, (b) psychosocial coping, and (c) care of the child; (4) patient/family education should occur across the continuum of care; and (5) a supportive environment is necessary to optimize learning. Dissemination and implementation of these recommendations will set the stage for future studies that aim to develop evidence to inform best practices, and ultimately to establish the standard of care for effective patient/family education in pediatric oncology.

A genomic audit of newly-adopted autosomal STRs for forensic identification.

Science.gov (United States)

Phillips, C

2017-07-01

In preparation for the growing use of massively parallel sequencing (MPS) technology to genotype forensic STRs, a comprehensive genomic audit of 73 STRs was made in 2016 [Parson et al., Forensic Sci. Int. Genet. 22, 54-63]. The loci examined included miniSTRs that were not in widespread use, but had been incorporated into MPS kits or were under consideration for this purpose. The current study expands the genomic analysis of autosomal STRs that are not commonly used, to include the full set of developed miniSTRs and an additional 24 STRs, most of which have been recently included in several supplementary forensic multiplex kits for capillary electrophoresis. The genomic audit of these 47 newly-adopted STRs examined the linkage status of new loci on the same chromosome as established forensic STRs; analyzed world-wide population variation of the newly-adopted STRs using published data; assessed their forensic informativeness; and compiled the sequence characteristics, repeat structures and flanking regions of each STR. A further 44 autosomal STRs developed for forensic analyses but not incorporated into commercial kits, are also briefly described. Copyright © 2017 Elsevier B.V. All rights reserved.

How Newcomers Learn the Social Norms of an Organization: A Case Study of the Socialization of Newly Hired Engineers

Science.gov (United States)

Korte, Russell F.

2009-01-01

Current scholarship views organizational socialization as a learning process that is primarily the responsibility of the newcomer. Yet recent learning research recognizes the importance of the social interactions in the learning process. This study investigated how newly hired engineers at a large manufacturing company learned job-related tasks…

Observation of the bone mineral density of newly formed bone using rabbits. Compared with newly formed bone around implants and cortical bone

International Nuclear Information System (INIS)

Nakada, Hiroshi; Numata, Yasuko; Sakae, Toshiro; Tamaki, Hiroyuki; Kato, Takao

2009-01-01

There have been many studies reporting that newly formed bone around implants is spongy bone. However, although the morphology is reported as being like spongy bone, it is difficult to discriminate whether the bone quality of newly formed bone appears similar to osteoid or cortical bone; therefore, evaluation of bone quality is required. The aims of this study were to measure the bone mineral density (BMD) values of newly formed bone around implants after 4, 8, 16, 24 and 48 weeks, to represent these values on three-dimensional color mapping (3Dmap), and to evaluate the change in bone quality associated with newly formed bone around implants. The animal experimental protocol of this study was approved by the Ethics Committee for Animal Experiments of our University. This experiment used 20 surface treatment implants (Ti-6Al-4V alloy: 3.1 mm in diameter and 30.0 mm in length) by grit-blasting. They were embedded into surgically created flaws in femurs of 20 New Zealand white rabbits (16 weeks old, male). The rabbits were sacrificed with an ear intravenous overdose of pentobarbital sodium under general anesthesia each period, and the femurs were resected. We measured BMD of newly formed bone around implants and cortical bone using Micro-CT, and the BMD distribution map of 3Dmap (TRI/3D Bon BMD, Ratoc System Engineering). The BMD of cortical bone was 1,026.3±44.3 mg/cm 3 at 4 weeks, 1,023.8±40.9 mg/cm 3 at 8 weeks, 1,048.2±45.6 mg/cm 3 at 16 weeks, 1,067.2±60.2 mg/cm 3 at 24 weeks, and 1,069.3±50.7 mg/cm 3 at 48 weeks after implantation, showing a non-significant increase each period. The BMD of newly formed bone around implants was 296.8±25.6 mg/cm 3 at 4 weeks, 525.0±72.4 mg/cm 3 at 8 weeks, 691.2±26.0 mg/cm 3 at 16 weeks, 776.9±27.7 mg/cm 3 at 24 weeks, and 845.2±23.1 mg/cm 3 at 48 weeks after implantation, showing a significant increase after each period. It was revealed that the color scale of newly formed bone was Low level at 4 weeks, and then it

Use of NESTLE computer code for NPP transition process analysis

International Nuclear Information System (INIS)

Gal'chenko, V.V.

2001-01-01

A newly created WWER-440 reactor model with use NESTLE code is discussed. Results of 'fast' and 'slow' transition processes based on it are presented. This model was developed for Rovno NPP reactor and it can be used also for WWER-1000 reactor in Zaporozhe NPP

Newly developed central diabetes insipidus following kidney transplantation: a case report.

Science.gov (United States)

Kim, K M; Kim, S M; Lee, J; Lee, S Y; Kwon, S K; Kim, H-Y

2013-09-01

Polyuria after kidney transplantation is a common, usually self-limiting disorder. However, persistent polyuria can cause not only patient discomfort, including polyuria and polydipsia, but also volume depletion that can produce allograft dysfunction. Herein, we have report a case of central diabetes insipidus newly diagnosed after kidney transplantation. A 45-year-old woman with end-stage kidney disease underwent deceased donor kidney transplantation. Two months after the transplantation, she was admitted for persistent polyuria, polydipsia, and nocturia with urine output of more than 4 L/d. Urine osmolarity was 100 mOsm/kg, which implied that the polyuria was due to water rather than solute diuresis. A water deprivation test was compatible with central diabetes insipidus; desmopressin treatment resulted in immediate symptomatic relief. Brain magnetic resonance imaging (MRI) demonstrated diffuse thickening of the pituitary stalk, which was considered to be nonspecific finding. MRI 12 months later showed no change in the pituitary stalk, although the patient has been in good health without polyuria or polydipsia on desmopressin treatment. The possibility of central diabetes insipidus should be considered in patients presenting with persistent polyuria after kidney transplantation. Copyright © 2013 Elsevier Inc. All rights reserved.

Newly graduated nurses' use of knowledge sources: a meta-ethnography.

Science.gov (United States)

Voldbjerg, Siri Lygum; Grønkjaer, Mette; Sørensen, Erik Elgaard; Hall, Elisabeth O C

2016-08-01

To advance evidence on newly graduated nurses' use of knowledge sources. Clinical decisions need to be evidence-based and understanding the knowledge sources that newly graduated nurses use will inform both education and practice. Qualitative studies on newly graduated nurses' use of knowledge sources are increasing though generated from scattered healthcare contexts. Therefore, a metasynthesis of qualitative research on what knowledge sources new graduates use in decision-making was conducted. Meta-ethnography. Nineteen reports, representing 17 studies, published from 2000-2014 were identified from iterative searches in relevant databases from May 2013-May 2014. Included reports were appraised for quality and Noblit and Hare's meta-ethnography guided the interpretation and synthesis of data. Newly graduated nurses' use of knowledge sources during their first 2-year postgraduation were interpreted in the main theme 'self and others as knowledge sources,' with two subthemes 'doing and following' and 'knowing and doing,' each with several elucidating categories. The metasynthesis revealed a line of argument among the report findings underscoring progression in knowledge use and perception of competence and confidence among newly graduated nurses. The transition phase, feeling of confidence and ability to use critical thinking and reflection, has a great impact on knowledge sources incorporated in clinical decisions. The synthesis accentuates that for use of newly graduated nurses' qualifications and skills in evidence-based practice, clinical practice needs to provide a supportive environment which nurtures critical thinking and questions and articulates use of multiple knowledge sources. © 2016 John Wiley & Sons Ltd.

The nanotoxicology of a newly developed zero-valent iron nanomaterial for groundwater remediation and its remediation efficiency assessment combined with in vitro bioassays for detection of dioxin-like environmental pollutants

OpenAIRE

Schiwy, Andreas Herbert

2016-01-01

The assessment of chemicals and new compounds is an important task of ecotoxicology. In this thesis a newly developed zero-valent iron material for nanoremediation of groundwater contaminations was investigated and in vitro bioassays for high throughput screening were developed. These two elements of the thesis were combined to assess the remediation efficiency of the nanomaterial on the groundwater contaminant acridine. The developed in vitro bioassays were evaluated for quantification of th...

Vibrational imaging of newly synthesized proteins in live cells by stimulated Raman scattering microscopy

Science.gov (United States)

Wei, Lu; Yu, Yong; Shen, Yihui; Wang, Meng C.; Min, Wei

2013-01-01

Synthesis of new proteins, a key step in the central dogma of molecular biology, has been a major biological process by which cells respond rapidly to environmental cues in both physiological and pathological conditions. However, the selective visualization of a newly synthesized proteome in living systems with subcellular resolution has proven to be rather challenging, despite the extensive efforts along the lines of fluorescence staining, autoradiography, and mass spectrometry. Herein, we report an imaging technique to visualize nascent proteins by harnessing the emerging stimulated Raman scattering (SRS) microscopy coupled with metabolic incorporation of deuterium-labeled amino acids. As a first demonstration, we imaged newly synthesized proteins in live mammalian cells with high spatial–temporal resolution without fixation or staining. Subcellular compartments with fast protein turnover in HeLa and HEK293T cells, and newly grown neurites in differentiating neuron-like N2A cells, are clearly identified via this imaging technique. Technically, incorporation of deuterium-labeled amino acids is minimally perturbative to live cells, whereas SRS imaging of exogenous carbon–deuterium bonds (C–D) in the cell-silent Raman region is highly sensitive, specific, and compatible with living systems. Moreover, coupled with label-free SRS imaging of the total proteome, our method can readily generate spatial maps of the quantitative ratio between new and total proteomes. Thus, this technique of nonlinear vibrational imaging of stable isotope incorporation will be a valuable tool to advance our understanding of the complex spatial and temporal dynamics of newly synthesized proteome in vivo. PMID:23798434

Certification document for newly generated contact-handled transuranic waste

International Nuclear Information System (INIS)

Box, W.D.; Setaro, J.

1984-01-01

The US Department of Energy has requested that all national laboratories handling defense waste develop and augment a program whereby all newly generated contact-handled transuranic (TRU) waste be contained, stored, and then shipped to the Waste Isolation Pilot Plant (WIPP) in accordance with the requirements set forth in WIPP-DOE-114. The program described in this report delineates how Oak Ridge National Laboratory intends to comply with these requirements and lists the procedures used by each generator to ensure that their TRU wastes are certifiable for shipment to WIPP

Component-based development process and component lifecycle

NARCIS (Netherlands)

Crnkovic, I.; Chaudron, M.R.V.; Larsson, S.

2006-01-01

The process of component- and component-based system development differs in many significant ways from the "classical" development process of software systems. The main difference is in the separation of the development process of components from the development process of systems. This fact has a

A newly developed spinal simulator.

Science.gov (United States)

Chester, R; Watson, M J

2000-11-01

A number of studies indicate poor intra-therapist and inter-therapist reliability in the performance of graded, passive oscillatory movements to the lumbar spine. However, it has been suggested that therapists can be trained to be more consistent in their performance of these techniques if given reliable quantitative feedback. The intention of this study was to develop equipment, analogous to the lumbar spine that could be used for both teaching and research purposes. Equipment has been updated and connected to a personal IBM compatible computer. Custom designed software allows concurrent and accurate feedback to students on their performance and in a form suitable for advanced data analysis using statistical packages. The uses and implications of this equipment are discussed. Copyright 2000 Harcourt Publishers Ltd.

Encounters of Newly Qualified Teachers with Micro-Politics in Primary Schools in Zimbabwe

Science.gov (United States)

Magudu, Snodia; Gumbo, Mishack

2017-01-01

This article demonstrates, through the example of Zimbabwe, the complexities of micro-political learning during induction. It reports on the experiences of ten newly qualified teachers with micro-politics or power relations in their schools during induction and locates these experiences within the broader context of their professional development.…

Assessment for markers of nephropathy in newly diagnosed type 2 ...

African Journals Online (AJOL)

Objective: To assess for markers of nephropathy in newly diagnosed type 2 diabetics, using blood pressure levels, endogenous creatinine clearance and urinary protein excretion as markers of renal disease. Study design: Ninety newly diagnosed type 2 diabetics were studied within 6 weeks of diagnosis. They were in ...

Efficacy of Intra-articular Injection of a Newly Developed Plasma Rich in Growth Factor (PRGF) Versus Hyaluronic Acid on Pain and Function of Patients with Knee Osteoarthritis: A Single-Blinded Randomized Clinical Trial

Science.gov (United States)

Raeissadat, Seyed Ahmad; Rayegani, Seyed Mansoor; Ahangar, Azadeh Gharooee; Abadi, Porya Hassan; Mojgani, Parviz; Ahangar, Omid Gharooi

2017-01-01

Background and objectives: Knee osteoarthritis is the most common joint disease. We aimed to compare the efficacy and safety of intra-articular injection of a newly developed plasma rich in growth factor (PRGF) versus hyaluronic acid (HA) on pain and function of patients with knee osteoarthritis. Methods: In this single-blinded randomized clinical trial, patients with symptomatic osteoarthritis of knee were assigned to receive 2 intra-articular injections of our newly developed PRGF in 3 weeks or 3 weekly injections of HA. Our primary outcome was the mean change from baseline until 2 and 6 months post intervention in scores of visual analog scale, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Lequesne index. We used analysis of variance for repeated-measures statistical test. Results: A total of 69 patients entered final analysis. The mean age of patients was 58.2 ± 7.41 years and 81.2% were women. In particular, total WOMAC index decreased from 42.9 ± 13.51 to 26.8 ± 13.45 and 24.4 ± 16.54 at 2 and 6 months in the newly developed PRGF group (within subjects P = .001), and from 38.8 ± 12.62 to 27.8 ± 11.01 and 27.4 ± 11.38 at 2 and 6 months in the HA group (within subjects P = .001), respectively (between subjects P = .631). There was no significant difference between PRGF and HA groups in patients’ satisfaction and minor complications of injection, whereas patients in HA group reported significantly lower injection-induced pain. Conclusions: In 6 months follow up, our newly developed PRGF and HA, both are effective options to decrease pain and improvement of function in patients with symptomatic mild to moderate knee osteoarthritis. PMID:29051707

Efficacy of Intra-articular Injection of a Newly Developed Plasma Rich in Growth Factor (PRGF Versus Hyaluronic Acid on Pain and Function of Patients with Knee Osteoarthritis: A Single-Blinded Randomized Clinical Trial

Directory of Open Access Journals (Sweden)

Seyed Ahmad Raeissadat

2017-10-01

Full Text Available Background and objectives: Knee osteoarthritis is the most common joint disease. We aimed to compare the efficacy and safety of intra-articular injection of a newly developed plasma rich in growth factor (PRGF versus hyaluronic acid (HA on pain and function of patients with knee osteoarthritis. Methods: In this single-blinded randomized clinical trial, patients with symptomatic osteoarthritis of knee were assigned to receive 2 intra-articular injections of our newly developed PRGF in 3 weeks or 3 weekly injections of HA. Our primary outcome was the mean change from baseline until 2 and 6 months post intervention in scores of visual analog scale, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC, and Lequesne index. We used analysis of variance for repeated-measures statistical test. Results: A total of 69 patients entered final analysis. The mean age of patients was 58.2 ± 7.41 years and 81.2% were women. In particular, total WOMAC index decreased from 42.9 ± 13.51 to 26.8 ± 13.45 and 24.4 ± 16.54 at 2 and 6 months in the newly developed PRGF group (within subjects P  = .001, and from 38.8 ± 12.62 to 27.8 ± 11.01 and 27.4 ± 11.38 at 2 and 6 months in the HA group (within subjects P  = .001, respectively (between subjects P  = .631. There was no significant difference between PRGF and HA groups in patients’ satisfaction and minor complications of injection, whereas patients in HA group reported significantly lower injection-induced pain. Conclusions: In 6 months follow up, our newly developed PRGF and HA, both are effective options to decrease pain and improvement of function in patients with symptomatic mild to moderate knee osteoarthritis.

Numerical and analytical investigation towards performance enhancement of a newly developed rockfall protective cable-net structure

Directory of Open Access Journals (Sweden)

S. Dhakal

2012-04-01

Full Text Available In a previous companion paper, we presented a three-tier modelling of a particular type of rockfall protective cable-net structure (barrier, developed newly in Japan. Therein, we developed a three-dimensional, Finite Element based, nonlinear numerical model having been calibrated/back-calculated and verified with the element- and structure-level physical tests. Moreover, using a very simple, lumped-mass, single-degree-of-freedom, equivalently linear analytical model, a global-displacement-predictive correlation was devised by modifying the basic equation – obtained by combining the principles of conservation of linear momentum and energy – based on the back-analysis of the tests on the numerical model. In this paper, we use the developed models to explore the performance enhancement potential of the structure in terms of (a the control of global displacement – possibly the major performance criterion for the proposed structure owing to a narrow space available in the targeted site, and (b the increase in energy dissipation by the existing U-bolt-type Friction-brake Devices – which are identified to have performed weakly when integrated into the structure. A set of parametric investigations have revealed correlations to achieve the first objective in terms of the structure's mass, particularly by manipulating the wire-net's characteristics, and has additionally disclosed the effects of the impacting-block's parameters. Towards achieving the second objective, another set of parametric investigations have led to a proposal of a few innovative improvements in the constitutive behaviour (model of the studied brake device (dissipator, in addition to an important recommendation of careful handling of the device based on the identified potential flaw.

Accumulation of operational history through emulation test to meet proven technology requirement for newly developed I and C technology

International Nuclear Information System (INIS)

Yeong Cheol, Shin; Sung Kon, Kang; Han Seong, Son

2006-01-01

As new advanced digital I and C technology with potential benefits of higher functionality and better cost effectiveness is available in the market, NPP (Nuclear Power Plant) operators are inclined to use the new technology for the construction of new plant and the upgrade of existing plants. However, this new technology poses risks to the NPP operators at the same time. These risks are mainly due to the poor reliability of newly developed technology. KHNP's past experiences with the new equipment shows many cases of reliability problems. And their consequences include unintended plant trips, lowered acceptance of the new digital technology by the plant I and C maintenance crew, and increased licensing burden in answering for questions from the nuclear regulatory body. Considering the fact that the risk of these failures in the nuclear plant operation is far greater than those in other industry, nuclear power plant operators want proven technology for I and C systems. This paper presents an approach for the emulation of operational history through which a newly developed technology becomes a proven technology. One of the essential elements of this approach is the feedback scheme of running the new equipment in emulated environment, gathering equipment failure, and correcting the design(and test bed). The emulation of environment includes normal and abnormal events of the new equipment such as reconfiguration of control system due to power failure, plant operation including full spectrum of credible scenarios in an NPP. Emulation of I and C equipment execution mode includes normal operation, initialization and termination, abnormal operation, hardware maintenance and maintenance of algorithm/software. Plant specific simulator is used to create complete profile of plant operational conditions that I and C equipment is to experience in the real plant. Virtual operating crew technology is developed to run the simulator scenarios without involvement of actual operators

Characteristics of low polymerization shrinkage flowable resin composites in newly-developed cavity base materials for bulk filling technique.

Science.gov (United States)

Nitta, Keiko; Nomoto, Rie; Tsubota, Yuji; Tsuchikawa, Masuji; Hayakawa, Tohru

2017-11-29

The purpose of this study was to evaluate polymerization shrinkage and other physical properties of newly-developed cavity base materials for bulk filling technique, with the brand name BULK BASE (BBS). Polymerization shrinkage was measured according to ISO/FDIS 17304. BBS showed the significantly lowest polymerization shrinkage and significantly higher depth of cure than conventional flowable resin composites (p<0.05). The Knoop hardness, flexural strength and elastic modulus of that were significantly lower than conventional flowable resin composites (p<0.05). BBS had the significantly greatest filler content (p<0.05). SEM images of the surface showed failure of fillers. The lowest polymerization shrinkage was due to the incorporation of a new type of low shrinkage monomer, which has urethane moieties. There were no clear correlations between inorganic filler contents and polymerization shrinkage, flexural strength and elastic modulus. In conclusion, the low polymerization shrinkage of BBS will be useful for cavity treatment in dental clinics.

Biochemical Process Development and Integration | Bioenergy | NREL

Science.gov (United States)

Biochemical Process Development and Integration Biochemical Process Development and Integration Our conversion and separation processes to pilot-scale integrated process development and scale up. We also Publications Accounting for all sugar produced during integrated production of ethanol from lignocellulosic

14 CFR 26.39 - Newly produced airplanes: Fuel tank flammability.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Newly produced airplanes: Fuel tank... Tank Flammability § 26.39 Newly produced airplanes: Fuel tank flammability. (a) Applicability: This... Series 767 Series (b) Any fuel tank meeting all of the criteria stated in paragraphs (b)(1), (b)(2) and...

Self-Esteem: A Comparison between Hong Kong Children and Newly Arrived Chinese Children

Science.gov (United States)

Chan, Yiu Man; Chan, Christine Mei-Sheung

2004-01-01

The Self-esteem Inventory developed by Coopersmith (1967) was used to measure the self-esteem of 387 Chinese children. The sample included newly arrived mainland Chinese children and Hong Kong children. The results showed significant statistical differences when measuring the self-esteem level associated with the length of their stay in Hong Kong…

Process control program development

International Nuclear Information System (INIS)

Dameron, H.J.

1985-01-01

This paper details the development and implementation of a ''Process Control Program'' at Duke Power's three nuclear stations - Oconee, McGuire, and Catawba. Each station is required by Technical Specification to have a ''Process Control Program'' (PCP) to control all dewatering and/or solidification activities for radioactive wastes

Development and upgrade of new real time processor in JT-60 data processing system

International Nuclear Information System (INIS)

Sakata, Shinya; Koiwa, Motonao; Matsuda, Toshiaki; Aoyagi, Tetsuo

2000-07-01

At the beginning of JT-60 experiments, the real time processor (RTP) in the data processing system was mainly constructed by PANAFACOM U-1500. As the computer became superannuated, however, it gradually became difficult to maintain both hardware and software. A performance of a recent UNIX workstation has been remarkably progressed. The UNIX workstation has a large flexibility for user application programs, an easiness for maintenance of the hardware and an ability of expansion to peripheral devices. Therefore, the RTP system is newly reconstructed by using the UNIX workstation. This report describes the overview, the basic design and the recent upgrade on the RTP in the data processing system. (author)

Development and performance of high speed processing system of magnetohydrodynamic equilibria for discharge analyses on the J T-60 tokamak

International Nuclear Information System (INIS)

Hasegawa, Yukihiro; Nakamura, Yukiharu; Shirai, Hiroshi; Hamamatsu, Kiyotaka; Harada, Yoshio; Kikuchi, Mitsuru; Nakata, Yoshihiro

1999-01-01

In order to provide a set of magnetohydrodynamic (MHD) equilibrium database which is indispensable for both the studies on improvement of energy confinement and stabilization of MHD activities in tokamaks, a high speed data-processing system synchronizing with J T-60 discharge sequence was newly developed by utilizing the latest model of hugh speed workstation and by optimizing the parallel processing technique to perform fast calculation of MHD equilibria. This high speed system was found to have a sufficient ability to complete the whole equilibrium calculations during each inter-shot period. Cooperating with the mass data storage subsystem preserving the latest equilibrium database automatically, the animated discharge monitoring subsystem provides valuable information for the J T-60 operator to determine control parameters of the succeeding discharge. This report describes the system performance realized in the J T-60 experiment. (author)

Chrysosplenium japonicum (Saxifragaceae, Newly Recorded from Taiwan

Directory of Open Access Journals (Sweden)

Tian-Chuan Hsu

2011-11-01

Full Text Available Chrysosplenium japonicum (Maxim. Makino (Saxifragaceae is newly recorded from northeastern Taiwan. Description, color photos and a key to the Chrysosplenium species in Taiwan are provided.

People newly in love are more responsive to positive feedback.

Science.gov (United States)

Brown, Cassandra L; Beninger, Richard J

2012-06-01

Passionate love is associated with increased activity in dopamine-rich regions of the brain. Increased dopamine in these regions is associated with a greater tendency to learn from reward in trial-and-error learning tasks. This study examined the prediction that individuals who were newly in love would be better at responding to reward (positive feedback). In test trials, people who were newly in love selected positive outcomes significantly more often than their single (not in love) counterparts but were no better at the task overall. This suggests that people who are newly in love show a bias toward responding to positive feedback, which may reflect a general bias towards reward-seeking.

The development of an innovative approach to postgraduate ultrasound education: An evolving process

International Nuclear Information System (INIS)

Gibbs, Vivien

2011-01-01

Increasing economic pressures on higher education institutions to limit the number of modules offered, together with the conflicting pressure from hospital departments requiring an increasingly skilled and flexible workforce, have resulted in the requirement for a more creative approach to delivery of university postgraduate programmes. One approach implemented at the University of the West of England, Bristol was to extend the role of an Action Based Learning (ABL) module within the Medical Ultrasound programme. Following completion of the first year of this newly accredited module, the experiences of students and staff were evaluated. Results of the evaluation and feedback demonstrated both positive and negative features of this style of learning, and the programme team decided to use this feedback to enhance the student experience for future cohorts undertaking the module. The second delivery of this module is now complete, and the module has again been evaluated. The following article discusses the evolutionary process involved in developing this module, and reviews the enhancements introduced over a two-year period.

Different patterns in the risk of newly developed fatty liver and lipid changes with tamoxifen versus aromatase inhibitors in postmenopausal women with early breast cancer: A propensity score-matched cohort study.

Science.gov (United States)

Hong, Namki; Yoon, Han Gyul; Seo, Da Hea; Park, Seho; Kim, Seung Il; Sohn, Joo Hyuk; Rhee, Yumie

2017-09-01

Management of metabolic complications of long-term adjuvant endocrine therapy in early breast cancer remained an unmet need. We aimed to compare the effects of tamoxifen (TMX) and aromatase inhibitors (AIs) on the risk of fatty liver in conjunction with longitudinal changes in the serum lipid parameters. Among 1203 subjects who were taking adjuvant TMX or AI (anastrozole or letrozole) without fatty liver at baseline, those taking TMX or AI were 1:1 matched on the propensity score. The primary outcome was newly developed fatty liver detected on annual liver ultrasonography. Among 328 matched subjects (mean age 53.5 years, body mass index 22.9 kg/m 2 ), 62 cases of fatty liver in the TMX group and 41 cases in the AI group were detected in a total of 987.4 person-years. The incidence rate of fatty liver was higher in the TMX group than in the AI group (128.7 versus 81.1 per 1000 person-years, P = 0.021), particularly within the first 2 years of therapy. TMX was associated with an increased 5-year risk of newly developed fatty liver (adjusted hazard ratio 1.61, P = 0.030) compared with AI independent of obesity and cholesterol level. Subjects who developed fatty liver had higher triglycerides (TGs) and lower high-density lipoprotein cholesterol (HDL-C) level at baseline than those without, which was sustained during follow-up despite the serum cholesterol-lowering effect of TMX. TMX independently increased the 5-year risk of newly developed fatty liver compared with AI in postmenopausal women with early breast cancer. Our findings suggest the need for considering the risk of fatty liver as a different adverse event profile between AI and TMX, particularly in patients with obesity, high TGs and low HDL-C. Copyright © 2017 Elsevier Ltd. All rights reserved.

The morphological development of newly inundated intertidal areas: the mechanisms driving the early evolution of an estuarine environment designed and constructed by humans

Science.gov (United States)

Dale, Jonathan; Burgess, Heidi; Cundy, Andrew

2017-04-01

Intertidal saltmarsh and mudflat habitats are of global importance due to the ecosystem, economic and cultural services they provide. These services include wildlife habitat provision and species diversity, immobilisation of pollutants and protection from coastal flooding. Saltmarsh and mudflat environments are, however, being lost and degraded due to erosion caused by rising sea levels and increased storminess. These losses are exacerbated by anthropogenic influences including land reclamation, increased coastal development and the construction of coastal flood defences which prevent the landwards migration of saltmarsh and mudflat environments, resulting in coastal squeeze. To compensate for saltmarsh and mudflat losses areas of the coastal hinterland are being inundated by breaching defences and constructing new defences inland, thus extending or constructing new estuarine environments; a processes known as de-embankment or managed realignment. Morphological engineering and landscaping within managed realignment sites prior to site inundation varies depending on the aims of the scheme. However, there is a shortage of data on the morphological evolution within these sites post site inundation impeding the ability of coastal engineers to effectively design and construct future sites. To date there has been a focus on the colonisation of marine macro fauna and flora within newly inundated managed realignment sites, which can be relatively rapid and easily quantified. Little is known of the morphological evolution in response to altered sedimentary processes, its driving mechanisms and therefore the success and ecological sustainability of these sites. This study evaluates the post-inundation morphological development of the largest open coast managed realignment site in Europe, at Medmerry on the south coast of the United Kingdom. Inundated in September 2013, the Medmerry Managed Realignment Site consists of a mosaic of former agricultural land and areas of lower

Similarities and Differences between Working Memory and Long-Term Memory: Evidence from the Levels-of-Processing Span Task

Science.gov (United States)

Rose, Nathan S.; Myerson, Joel; Roediger, Henry L., III; Hale, Sandra

2010-01-01

Two experiments compared the effects of depth of processing on working memory (WM) and long-term memory (LTM) using a levels-of-processing (LOP) span task, a newly developed WM span procedure that involves processing to-be-remembered words based on their visual, phonological, or semantic characteristics. Depth of processing had minimal effect on…

Image processing using pulse-coupled neural networks applications in Python

CERN Document Server

Lindblad, Thomas

2013-01-01

Image processing algorithms based on the mammalian visual cortex are powerful tools for extraction information and manipulating images. This book reviews the neural theory and translates them into digital models. Applications are given in areas of image recognition, foveation, image fusion and information extraction. The third edition reflects renewed international interest in pulse image processing with updated sections presenting several newly developed applications. This edition also introduces a suite of Python scripts that assist readers in replicating results presented in the text and to further develop their own applications.

Developing engineering processes through integrated modelling of product and process

DEFF Research Database (Denmark)

Nielsen, Jeppe Bjerrum; Hvam, Lars

2012-01-01

This article aims at developing an operational tool for integrated modelling of product assortments and engineering processes in companies making customer specific products. Integrating a product model in the design of engineering processes will provide a deeper understanding of the engineering...... activities as well as insight into how product features affect the engineering processes. The article suggests possible ways of integrating models of products with models of engineering processes. The models have been tested and further developed in an action research study carried out in collaboration...... with a major international engineering company....

Workplace Violence and Job Outcomes of Newly Licensed Nurses

OpenAIRE

Chang, Hyoung Eun; Cho, Sung-Hyun

2016-01-01

Purpose: The purpose of this study was to examine the prevalence of workplace violence toward newly licensed nurses and the relationship between workplace violence and job outcomes. Methods: An online survey was conducted of newly licensed registered nurses who had obtained their license in 2012 or 2013 in South Korea and had been working for 5–12 months after first being employed. The sample consisted of 312 nurses working in hospitals or clinics. The Copenhagen Psychosocial Questionnaire...

Development of synthetic gasoline production process

Energy Technology Data Exchange (ETDEWEB)

Imai, T; Fujita, H; Yamada, K; Suzuki, T; Tsuchida, Y

1986-01-01

As oil deposits are limited, it is very important to develop techniques for manufacturing petroleum alternatives as substitute energy sources to brighten the outlook for the future. The Research Association for Petroleum Alternatives Development (RAPAD) in Japan is engaged in the research and development of production techniques for light hydrocarbon oils such as gasoline, kerosene, and light oil from synthesis gas (CO, H/sub 2/) obtained from the raw materials of natural gas, coal, etc. Regarding the MTG process of synthesizing gasoline via methanol from synthesis gas and the STG process of directly synthesizing gasoline from synthesis gas, Cosmo Oil Co., Ltd. and Mitsubishi Heavy Industries, Ltd., members of RAPAD, have sought jointly to develop catalysts and processes. As a result of this co-operation, the authors have recently succeeded in developing a new catalyst with a long life span capable of providing a high yield and high selectivity. Additionally, the authors are currently on the verge of putting into effect a unique two-step STG process of synthesizing high octane gasoline via dimethyl ether, referred to as the AMSTG process.

Investigation of various reconstruction parameters for algebraic reconstruction technique in a newly developed chest digital tomosynthesis

International Nuclear Information System (INIS)

Lee, H.; Choi, S.; Kim, Y.-S.; Park, H.-S.; Seo, C.-W.; Kim, H.-J.; Lee, D.; Lee, Y.

2017-01-01

Chest digital tomosynthesis (CDT) is a promising new modality that provides 3D information by reconstructing limited projection views. CDT systems have been developed to improve the limitations of conventional radiography such as image degradation and low sensitivity. However, the development of reconstruction methods is challenging because of the limited projection views within various angular ranges. Optimization of reconstruction parameters for various reconsturction methods in CDT system also is needed. The purpose of this study was to investigate the feasibility of algebraic reconstruction technique (ART) method, and to evaluate the effect of the reconstruction parameters for our newly developed CDT system. We designed ART method with 41 projection views over an angular range of ±20°. To investigate the effect of reconstruction parameters, we measured the contrast-to-noise ratio (CNR), artifact spread function (ASF), and quality factor (QF) using LUNGMAN phantom included tumors. We found that the proper choice of reconstruction parameters such as relaxation parameter, initial guess, and number of iterations improved the quality of reconstructed images from the same projection views. Optimal values of ART relaxation parameter with uniform (UI) and back-projection (BP) initial guesses were 0.4 and 0.6, respectively. BP initial guess improved image quality in comparison with UI initial guess, in terms of providing a higher CNR and QF values with a faster speed. CNR and QF values improved with increasing number of iteration. Particularly, ART method with BP initial guess (when β = 0.6) after 3-terations provide satisfactory reconstructed image. In conclusion, the use of ART method with proper reconstruction parameters provided better image quality than FBP method as well as conventional radiography. These results indicated that the ART method with optimal reconstruction parameters could improve image quality for nodule detection using the CDT system.

Investigation of various reconstruction parameters for algebraic reconstruction technique in a newly developed chest digital tomosynthesis

Science.gov (United States)

Lee, H.; Choi, S.; Lee, D.; Kim, Y.-s.; Park, H.-S.; Lee, Y.; Seo, C.-W.; Kim, H.-J.

2017-08-01

Chest digital tomosynthesis (CDT) is a promising new modality that provides 3D information by reconstructing limited projection views. CDT systems have been developed to improve the limitations of conventional radiography such as image degradation and low sensitivity. However, the development of reconstruction methods is challenging because of the limited projection views within various angular ranges. Optimization of reconstruction parameters for various reconsturction methods in CDT system also is needed. The purpose of this study was to investigate the feasibility of algebraic reconstruction technique (ART) method, and to evaluate the effect of the reconstruction parameters for our newly developed CDT system. We designed ART method with 41 projection views over an angular range of ±20°. To investigate the effect of reconstruction parameters, we measured the contrast-to-noise ratio (CNR), artifact spread function (ASF), and quality factor (QF) using LUNGMAN phantom included tumors. We found that the proper choice of reconstruction parameters such as relaxation parameter, initial guess, and number of iterations improved the quality of reconstructed images from the same projection views. Optimal values of ART relaxation parameter with uniform (UI) and back-projection (BP) initial guesses were 0.4 and 0.6, respectively. BP initial guess improved image quality in comparison with UI initial guess, in terms of providing a higher CNR and QF values with a faster speed. CNR and QF values improved with increasing number of iteration. Particularly, ART method with BP initial guess (when β = 0.6) after 3-terations provide satisfactory reconstructed image. In conclusion, the use of ART method with proper reconstruction parameters provided better image quality than FBP method as well as conventional radiography. These results indicated that the ART method with optimal reconstruction parameters could improve image quality for nodule detection using the CDT system.

Study of surface energy budget and test of a newly developed fast photoacoustic spectroscopy based hygrometer in field campaign Szeged (Hungary)

Science.gov (United States)

Tatrai, David; Nikov, Daniella; Zsolt Jász, Ervin; Bozóki, Zoltán; Szabó, Gábor; Weidinger, Tamás; András Gyöngyösi, Zénó; Kiss, Melinda; Józsa, János; Simó Diego, Gemma; Cuxart Rodamilans, Joan; Wrenger, Burkhart; Bottyán, Zsolt

2014-05-01

A micrometeorological field measurement campaign dedicated to study the surface energy budget and the structure of the boundary layer focusing on the transient layer forming periods during night-time was organized in the period of 10th of November to 3rd of December 2013 in the nearby of Szeged, Hungary. A temporary micrometeorological measurement station was set up at the coordinates N:46.239943; E:20.089758, approximately 1700 m far from a national meteorology station (N:46.255711; E:20.09052). In the experimental micrometeorological site different types of instruments were installed to measure numerous parameters: standard meteorological measurements (p, T, wet, wind speed and direction at three different levels, relative humidity at two levels and absolute humidity at one level) radiation budget components surface temperature and leaf wetness soil temperature, moisture and heat flux into the deeper soil layer eddy-covariance measurements (t, H, LE CO2) at 3 m level using Campbell open-path IRGA (EC150) system. At the national meteorology station (http://adatok.geo.u-szeged.hu/?lang=eng) besides their standard measurement equipment and measurement routine a SODAR was installed and continuously operated. These ground based measurements were combined with and supported by UAV, quadcopter and tethered balloon based vertical profile measurements of p, T, rh. For this measurement campaign as a modification of a previously developed airborne ready dual channel hygrometer, a fast photoacoustic spectroscopy based hygrometer was developed for absolute humidity measurements. The estimated response time of the system is faster than 15 Hz, which was achieved by the replacement of the data acquisition system and by recording the raw photoacoustic signal sampled at rate of 48 kHz for post-processing. During the campaign this new system was compared to a TDL system commercially available at Li-COR Inc. Besides the testing of the newly developed fast photoacoustic hygrometer

Lean automation development : applying lean principles to the automation development process

OpenAIRE

Granlund, Anna; Wiktorsson, Magnus; Grahn, Sten; Friedler, Niklas

2014-01-01

By a broad empirical study it is indicated that automation development show potential of improvement. In the paper, 13 lean product development principles are contrasted to the automation development process and it is suggested why and how these principles can facilitate, support and improve the automation development process. The paper summarises a description of what characterises a lean automation development process and what consequences it entails. Main differences compared to current pr...

Assessment of salt tolerance of some newly developed and candidate wheat (triticum aestivum l.) cultivars using gas exchange and chlorophyll fluorescence attributes

International Nuclear Information System (INIS)

Kanwal, H.; Shahbaz, M.; Ashraf, M.

2011-01-01

The present study was aimed to assess salt tolerance of some newly developed and candidate cultivars of wheat using gas exchange and chlorophyll fluorescence parameters. Ten wheat cultivars including five newly developed (S-24, Saher-2006, Fsd-2008, Lasani and Inqlab-91) and five candidate (P .B-18, M.P-65, S.H-20, AARI-10 and G.A-20) were grown in sand culture. Salt stress (150 mM NaCl in Hoagland's nutrient solution) was applied at the seedling stage. A significant reduction in plant biomass production was recorded in all wheat cultivars. Cultivars S-24, Saher-2006 and Fsd-2008 showed less reduction in biomass production as compared with the other cultivars. Different gas exchange attributes such as leaf net photosynthetic rate (A), transpiration rate ( E), and stomatal conductance (gs) were also adversely affected due to salt stress and were positively associated with the plant biomass production of the genotypes under saline stress. More negative effects in relation to these gas exchange attributes were recorded in cvs. Lasani, G.A-20 and ARRI-10 than those in the other cultivars. Leaf maximum chlorophyll fluorescence (Fm), maximum fluorescence at steady state (Fms ), and photochemical fluorescence quenching (Qp) increased while maximum quantum yield (Fv/Fm), quantum yield of electron transport (Qp), electron transport rate ( ETR ) and non-photochemical quenching (Qn) decreased due to imposition of salt stress. The adverse effects of salt stress on these chlorophyll fluorescence attributes were minimum in cultivars S-24, Saher-2006 and Fsd-2008. A significant positive correlation was recorded between biomass production, different gas exchange attributes and chlorophyll fluorescence parameters. Overall, cvs. S-24, Saher-2006 and Fsd-2008 were ranked as salt tolerant on the basis of their performance in biomass production, gas exchange attributes and chlorophyll fluorescence parameters. (author)

Extreme thermophilic ethanol production from rapeseed straw: using the newly isolated Thermoanaerobacter pentosaceus and combining it with Saccharomyces cerevisiae in a two-step process

DEFF Research Database (Denmark)

Tomás, Ana Faria; Karagöz, Pınar; Karakashev, Dimitar Borisov

2013-01-01

from the liquid fraction of pretreated rapeseed straw, without any dilution or need for additives. However, when the hydrolysate was used undiluted the ethanol yield was only 37% compared to yield of the control, in which pure sugars in synthetic medium were used. The decrease of ethanol yield...... showed that the two strains together could achieve up to 85% of the theoretical ethanol yield based on the sugar composition of the rapeseed straw, which was 14% and 50% higher compared to the yield with the yeast or the bacteria alone, respectively. Biotechnol. Bioeng. © 2012 Wiley Periodicals, Inc.......The newly isolated extreme thermophile Thermoanaerobacter pentosaceus was used for ethanol production from alkaline-peroxide pretreated rapeseed straw (PRS). Both the liquid and solid fractions of PRS were used. T. pentosaceus was able to metabolize the typical process inhibitors present...

The role of infections and coinfections with newly identified and emerging respiratory viruses in children

Directory of Open Access Journals (Sweden)

Debiaggi Maurizia

2012-10-01

Full Text Available Abstract Acute respiratory infections are a major cause of morbidity in children both in developed and developing countries. A wide range of respiratory viruses, including respiratory syncytial virus (RSV, influenza A and B viruses, parainfluenza viruses (PIVs, adenovirus, rhinovirus (HRV, have repeatedly been detected in acute lower respiratory tract infections (LRTI in children in the past decades. However, in the last ten years thanks to progress in molecular technologies, newly discovered viruses have been identified including human Metapneumovirus (hMPV, coronaviruses NL63 (HcoV-NL63 and HKU1 (HcoV-HKU1, human Bocavirus (HBoV, new enterovirus (HEV, parechovirus (HpeV and rhinovirus (HRV strains, polyomaviruses WU (WUPyV and KI (KIPyV and the pandemic H1N1v influenza A virus. These discoveries have heavily modified previous knowledge on respiratory infections mainly highlighting that pediatric population is exposed to a variety of viruses with similar seasonal patterns. In this context establishing a causal link between a newly identified virus and the disease as well as an association between mixed infections and an increase in disease severity can be challenging. This review will present an overview of newly recognized as well as the main emerging respiratory viruses and seek to focus on the their contribution to infection and co-infection in LRTIs in childhood.

Technical leadership development: Speeding up the process

International Nuclear Information System (INIS)

Bilger, W.T.; Shropshire, J.C.; Coleman, S.L.; Collins, R.

1993-01-01

This paper describes the Applied Engineering Fundamentals Course, a 14-week course designed for newly hired U.S. Department of Energy (DOE) engineers and scientists who will assume oversight responsibilities at technically complex facilities. This course includes formal education and training, an applications course in the field, and rotational assignments

Exploring Content Validity of Shore Handwriting Screening and Newly Developed Score Sheet With Pre-Kindergarten Students

Directory of Open Access Journals (Sweden)

Denise K. Donica

2015-07-01

Full Text Available Background: Limited tools exist to measure handwriting readiness skills of pre-kindergarten students. This study was a preliminary exploration of content validity of the Shore Handwriting Screening (SHS and the newly developed Score Sheet with the Bruininks-Oseretsky Test of Motor Proficiency, Second Edition (BOT-2 in 4- and 5-year-old pre-kindergarten students. Because socioeconomic status (SES is known to impact handwriting skills, data from two different socioeconomic groups were collected. Method: Students from a Lower SES group (n = 36 and a Higher SES group (n = 14 completed the SHS and fine motor composite of the BOT-2. Pearson’s correlation was used to compare scores on the two assessments within the two groups. Results: SHS overall percentage scores were compared to standard scores and composite scores of the BOT-2. SHS scores displayed moderate to high correlation with fine manual control portions of the BOT-2 for the Lower SES group and low to moderate correlation for the same portion in the Higher SES group. Conclusion: SHS and the Score Sheet correlate to fine and visual-motor skill subtests on the fine manual control portions of the BOT-2, which supports the need for further research on the reliability and validity of the Score Sheet for use in practice.

Venezuela: from doctrine to dialogue to participation in the processes of regional development.

Science.gov (United States)

Allor, D J

1984-01-01

. Neighborhood associations were mentioned in the decree, but their role was not formalized. This series of newly established bodies plays a role in both advisory and administrative processes. The advisory process begins at the lowest level, and local concerns are expressed upward through the hierarchy. The administrative process flows in the opposite direction. Participation remains highly formalized and is restricted to the participation of recognized leaders and organizations. For example, members of the Assembly of Participation include the state governor, representatives of municipal councils, and representatives of various industrial and commercial organizations. Despite the formal nature of the participation, the 1980 Decree clearly exhibited the trend toward decentralization predicted by John Freeman in his analysis of Venezuelan political structure and published in a book entitled "venezuela: From doctrine to Dialogue." Increased pressure will now be exerted for broader community participation in the development process, and eventually development planning will focus on the equitable distribution of development benefits rather than on the maximization of economic growth.

Radioactive Dry Process Material Treatment Technology Development

Energy Technology Data Exchange (ETDEWEB)

Park, J. J.; Hung, I. H.; Kim, K. K. (and others)

2007-06-15

The project 'Radioactive Dry Process Material Treatment Technology Development' aims to be normal operation for the experiments at DUPIC fuel development facility (DFDF) and safe operation of the facility through the technology developments such as remote operation, maintenance and pair of the facility, treatment of various high level process wastes and trapping of volatile process gases. DUPIC Fuel Development Facility (DFDF) can accommodate highly active nuclear materials, and now it is for fabrication of the oxide fuel by dry process characterizing the proliferation resistance. During the second stage from march 2005 to February 2007, we carried out technology development of the remote maintenance and the DFDF's safe operation, development of treatment technology for process off-gas, and development of treatment technology for PWR cladding hull and the results was described in this report.

Identifying and Prioritizing Gaps in Neuroendocrine Tumor Research: A Modified Delphi Process With Patients and Health Care Providers to Set the Research Action Plan for the Newly Formed Commonwealth Neuroendocrine Tumor Collaboration

Directory of Open Access Journals (Sweden)

Eva Segelov

2017-08-01

Full Text Available Purpose: Neuroendocrine tumors (NETs are a diverse group of malignancies that pose challenges common to all rare tumors. The Commonwealth Neuroendocrine Tumor Collaboration (CommNETS was established in 2015 to enhance outcomes for patients with NETs in Canada, Australia, and New Zealand. A modified Delphi process was undertaken involving patients, clinicians, and researchers to identify gaps in NETs research to produce a comprehensive and defensible research action plan. Methods: A three-round modified Delphi process was undertaken with larger representation than usual for medical consensus processes. Patient/advocate and health care provider/researcher expert panels undertook Round 1, which canvassed 17 research priorities and 42 potential topics; in Round 2, these priorities were ranked. Round 3 comprised a face-to-face meeting to generate final consensus rankings and formulate the research action plan. Results: The Delphi groups consisted of 203 participants in Round 1 (64% health care providers/researchers, 36% patient/advocates; 52% Canadian, 32% Australian, and 17% New Zealander, of whom 132 participated in Round 2. The top eight priorities were biomarker development; peptide receptor radionuclide therapy optimization; trials of new agents in advanced NETs; functional imaging; sequencing therapies for metastatic NETs, including development of validated surrogate end points for studies; pathologic classification; early diagnosis; interventional therapeutics; and curative surgery. Two major areas were ranked significantly higher by patients/advocates: early diagnosis and curative surgery. Six CommNETS working parties were established. Conclusion: This modified Delphi process resulted in a well-founded set of research priorities for the newly formed CommNETS collaboration by involving a large, diverse group of stakeholders. This approach to setting a research agenda for a new collaborative group should be adopted to ensure that research plans

Identifying and Prioritizing Gaps in Neuroendocrine Tumor Research: A Modified Delphi Process With Patients and Health Care Providers to Set the Research Action Plan for the Newly Formed Commonwealth Neuroendocrine Tumor Collaboration.

Science.gov (United States)

Segelov, Eva; Chan, David; Lawrence, Ben; Pavlakis, Nick; Kennecke, Hagen F; Jackson, Christopher; Law, Calvin; Singh, Simron

2017-08-01

Neuroendocrine tumors (NETs) are a diverse group of malignancies that pose challenges common to all rare tumors. The Commonwealth Neuroendocrine Tumor Collaboration (CommNETS) was established in 2015 to enhance outcomes for patients with NETs in Canada, Australia, and New Zealand. A modified Delphi process was undertaken involving patients, clinicians, and researchers to identify gaps in NETs research to produce a comprehensive and defensible research action plan. A three-round modified Delphi process was undertaken with larger representation than usual for medical consensus processes. Patient/advocate and health care provider/researcher expert panels undertook Round 1, which canvassed 17 research priorities and 42 potential topics; in Round 2, these priorities were ranked. Round 3 comprised a face-to-face meeting to generate final consensus rankings and formulate the research action plan. The Delphi groups consisted of 203 participants in Round 1 (64% health care providers/researchers, 36% patient/advocates; 52% Canadian, 32% Australian, and 17% New Zealander), of whom 132 participated in Round 2. The top eight priorities were biomarker development; peptide receptor radionuclide therapy optimization; trials of new agents in advanced NETs; functional imaging; sequencing therapies for metastatic NETs, including development of validated surrogate end points for studies; pathologic classification; early diagnosis; interventional therapeutics; and curative surgery. Two major areas were ranked significantly higher by patients/advocates: early diagnosis and curative surgery. Six CommNETS working parties were established. This modified Delphi process resulted in a well-founded set of research priorities for the newly formed CommNETS collaboration by involving a large, diverse group of stakeholders. This approach to setting a research agenda for a new collaborative group should be adopted to ensure that research plans reflect unmet needs and priorities in the field.

An Exploration of Changes in Thinking in the Transition from Student Teacher to Newly Qualified Teacher

Science.gov (United States)

Haggarty, Linda; Postlethwaite, Keith

2012-01-01

For newly qualified teachers (NQTs), the induction period of support is an important phase which has the potential to deepen learning that has already taken place in initial teacher education (ITE) as well as preparing the NQT for future learning. A particularly crucial time in the induction process is the first term of teaching, when NQTs are…

Exercise recommendations in patients with newly diagnosed fibromyalgia.

Science.gov (United States)

Wilson, Brad; Spencer, Horace; Kortebein, Patrick

2012-04-01

To evaluate exercise recommendations in patients newly diagnosed with fibromyalgia. A retrospective chart review. A public university rheumatology clinic. Patients newly diagnosed with fibromyalgia (N = 122). Frequency and type of exercise recommendations. The mean (standard deviation) age of these patients with fibromyalgia was 45 ± 12 years; 91% were women. Exercise was recommended as part of the documented treatment plan in 47% of these patients (57/122); only 3 patients had a documented contraindication for exercise. Aquatic exercise was most frequently recommended (56% [32/57]), followed by combined aquatic-aerobic exercise (26% [15/57]), and, infrequently, aerobic exercise only (5% [3/57]); only 7% of these patients (4/57) were referred for physical therapy. The primary method of communication was verbal discussion (94% [54/57]). Although there is well-documented evidence that exercise is beneficial for patients with fibromyalgia, we found that less than half of patients with newly diagnosed fibromyalgia in our study were provided recommendations to initiate an exercise program as part of their treatment plan. Further investigation of these findings are warranted, including evaluation of other university and community rheumatology practices as well as that of other physicians caring for patients with fibromyalgia. However, our findings indicate that there appears to be an opportunity to provide more specific and practical education regarding the implementation of an exercise regimen for patients with newly diagnosed fibromyalgia. Physiatrists may be particularly well suited to manage the exercise component of patients with fibromyalgia because of their specialized training in exercise prescription. Copyright © 2012 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.

The MINERVA Software Development Process

Science.gov (United States)

Narkawicz, Anthony; Munoz, Cesar A.; Dutle, Aaron M.

2017-01-01

This paper presents a software development process for safety-critical software components of cyber-physical systems. The process is called MINERVA, which stands for Mirrored Implementation Numerically Evaluated against Rigorously Verified Algorithms. The process relies on formal methods for rigorously validating code against its requirements. The software development process uses: (1) a formal specification language for describing the algorithms and their functional requirements, (2) an interactive theorem prover for formally verifying the correctness of the algorithms, (3) test cases that stress the code, and (4) numerical evaluation on these test cases of both the algorithm specifications and their implementations in code. The MINERVA process is illustrated in this paper with an application to geo-containment algorithms for unmanned aircraft systems. These algorithms ensure that the position of an aircraft never leaves a predetermined polygon region and provide recovery maneuvers when the region is inadvertently exited.

Critical thinking dispositions among newly graduated nurses.

Science.gov (United States)

Wangensteen, Sigrid; Johansson, Inger S; Björkström, Monica E; Nordström, Gun

2010-10-01

The aim of the study was to describe critical thinking dispositions among newly graduated nurses in Norway, and to study whether background data had any impact on critical thinking dispositions. Competence in critical thinking is one of the expectations of nursing education. Critical thinkers are described as well-informed, inquisitive, open-minded and orderly in complex matters. Critical thinking competence has thus been designated as an outcome for judging the quality of nursing education programmes and for the development of clinical judgement. The ability to think critically is also described as reducing the research-practice gap and fostering evidence-based nursing. A cross-sectional descriptive study was performed. The data were collected between October 2006 and April 2007 using the California Critical Thinking Disposition Inventory. The response rate was 33% (n = 618). Pearson's chi-square tests were used to analyse the data. Nearly 80% of the respondents reported a positive disposition towards critical thinking. The highest mean score was on the Inquisitiveness subscale and the lowest on the Truth-seeking subscale. A statistically significant higher proportion of nurses with high critical thinking scores were found among those older than 30 years, those with university education prior to nursing education, and those working in community health care. Nurse leaders and nurse teachers should encourage and nurture critical thinking among newly graduated nurses and nursing students. The low Truth-seeking scores found may be a result of traditional teaching strategies in nursing education and might indicate a need for more student-active learning models. © 2010 The Authors. Journal of Advanced Nursing © 2010 Blackwell Publishing Ltd.

Development of functionally-oriented technological processes of electroerosive processing

Science.gov (United States)

Syanov, S. Yu

2018-03-01

The stages of the development of functionally oriented technological processes of electroerosive processing from the separation of the surfaces of parts and their service functions to the determination of the parameters of the process of electric erosion, which will provide not only the quality parameters of the surface layer, but also the required operational properties, are described.

The ecological and construct validity of a newly developed measure of executive function: the Virtual Library Task.

Science.gov (United States)

Renison, Belinda; Ponsford, Jennie; Testa, Renee; Richardson, Barry; Brownfield, Kylie

2012-05-01

Virtual reality (VR) assessment paradigms have the potential to address the limited ecological validity of pen and paper measures of executive function (EF) and the pragmatic and reliability issues associated with functional measures. To investigate the ecological validity and construct validity of a newly developed VR measure of EF, the Virtual Library Task (VLT); a real life analogous task--the Real Library Task (RLT); and five neuropsychological measures of EF were administered to 30 patients with traumatic brain injury (TBI) and 30 healthy Controls. Significant others for each participant also completed the Dysexecutive Questionnaire (DEX), which is a behavioral rating scale of everyday EF. Performances on the VLT and the RLT were significantly positively correlated indicating that VR performance is similar to real world performance. The TBI group performed significantly worse than the Control group on the VLT and the Modified Six Elements Test (MSET) but the other four neuropsychological measures of EF failed to differentiate the groups. Both the MSET and the VLT significantly predicted everyday EF suggesting that they are both ecologically valid tools for the assessment of EF. The VLT has the advantage over the MSET of providing objective measurement of individual components of EF.

Heat and mass transfer during the inductive skull melting process of glasses and oxides; Waerme- und Stofftransport beim induktiven Skull-Schmelzen von Glaesern und Oxiden

Energy Technology Data Exchange (ETDEWEB)

Nacke, Bernard; Niemann, Benjamin [Leibniz Univ. Hannover (Germany). Inst. fuer Elektroprozesstechnik; Schlesselmann, Dirk [Auer Lighting GmbH, Bad Gandersheim (Germany)

2013-03-15

The skull melting technology is a melting process for innovative materials in the range of glasses. A hitherto unknown problem under glass melting by means of this technology is the fact that the processes in the interior of the molten mass are still unknown. Under this aspect, the authors of the contribution under consideration present an overview of the inductive melting process for glasses in an inductor crucible developed at the Institute for Electrotechnology (Hanover, Federal Republic of Germany). A newly developed numerical model is presented in order to simulate the heat and mass transfer in a molten glass. This simulation enables a future optimization of the design of the inductor crucible and the melting process. The transient three-dimensional melting flow during the melting of glasses and oxides by means of the skull meeting process also can be simulated by the newly developed numerical model.

The Development of Analogical Reasoning Processes.

Science.gov (United States)

Sternberg, Robert J.; Rifkin, Bathsheva

1979-01-01

Two experiments were conducted to test the generalizability to children of a theory of analogical reasoning processes, originally proposed for adults, and to examine the development of analogical reasoning processes in terms of five proposed sources of cognitive development. (MP)

Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia

DEFF Research Database (Denmark)

Saglio, Giuseppe; Kim, Dong-Wook; Issaragrisil, Surapol

2010-01-01

Nilotinib has been shown to be a more potent inhibitor of BCR-ABL than imatinib. We evaluated the efficacy and safety of nilotinib, as compared with imatinib, in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (CML) in the chronic phase.......Nilotinib has been shown to be a more potent inhibitor of BCR-ABL than imatinib. We evaluated the efficacy and safety of nilotinib, as compared with imatinib, in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (CML) in the chronic phase....

Transformation of organic N newly added to red soil treated with different cultural practices

Institute of Scientific and Technical Information of China (English)

ZhangQin－Zheng; YeQing－Fu; 等

1998-01-01

By using 15N tracer method,transformation of organic N,which wqas newly added to red soil treated with different cultural practices,was studied under thelaboratory incubation condition.The experimental results showed that the transformation of N from newly added organic matter and soil native pool during incubation was influenced by cultural practice treatment beforeincubation.Fallow was favorable to the mineralization of newly added organic N and soil N compared with the planting wheat treatment.Planting wheat greatly increased the loss of soil N.Application of fertilizers stimulated the mineralization of newly added organic N and application of organic matter reduced the mineralization,but stimulated microbialtransformation of newly adde4d organic N.

UCSD SORT Test (U-SORT): Examination of a newly developed organizational skills assessment tool for severely mentally ill adults.

Science.gov (United States)

Tiznado, Denisse; Mausbach, Brent T; Cardenas, Veronica; Jeste, Dilip V; Patterson, Thomas L

2010-12-01

The present investigation examined the validity of a new cognitive test intended to assess organizational skills. Participants were 180 middle-aged or older participants with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnosis of schizophrenia or schizoaffective disorder. Participants' organizational skills were measured using our newly developed University of California, San Diego Sorting Test (U-SORT), a performance-based test of organizational ability in which subjects sort objects (e.g., battery, pens) from a "junk drawer" into "keep" versus "trash" piles. Significant correlations between U-SORT scores and theoretically similar constructs (i.e. functional capacity, cognitive functioning, and clinical symptoms) were acceptable (mean r = 0.34), and weak correlations were found between U-SORT scores and theoretically dissimilar constructs (e.g., health symptoms, social support, gender; mean r = 0.06 ). The correlation between assessment scores provides preliminary support for the U-SORT test as a brief, easily transportable, reliable, and valid measure of functioning for this population.

Development of a one-step RT-PCR assay for detection of pancoronaviruses (α-, β-, γ-, and δ-coronaviruses) using newly designed degenerate primers for porcine and avian `fecal samples.

Science.gov (United States)

Hu, Hui; Jung, Kwonil; Wang, Qiuhong; Saif, Linda J; Vlasova, Anastasia N

2018-06-01

Coronaviruses (CoVs) are critical human and animal pathogens because of their potential to cause severe epidemics of respiratory or enteric diseases. In pigs, the newly emerged porcine deltacoronavirus (PDCoV) and re-emerged porcine epidemic diarrhea virus (PEDV) reported in the US and Asia, as well as the discovery of novel CoVs in wild bats or birds, has necessitated development of improved detection and control measures for these CoVs. Because the previous pancoronavirus (panCoV) RT-PCR established in our laboratory in 2007-2011 did not detect deltacoronaviruses (δ-CoVs) in swine fecal and serum samples, our goal was to develop a new panCoV RT-PCR assay to detect known human and animal CoVs, including δ-CoVs. In this study, we designed a new primer set to amplify a 668 bp-region within the RNA-dependent RNA polymerase (RdRP) gene that encodes the most conserved protein domain of α-, β-, γ-, and δ-CoVs. We established a one-step panCoV RT-PCR assay and standardized the assay conditions. The newly established panCoV RT-PCR assay was demonstrated to have a high sensitivity and specificity. Using a panel of 60 swine biological samples (feces, intestinal contents, and sera) characterized by PEDV, PDCoV and transmissible gastroenteritis virus-specific RT-PCR assays, we demonstrated that sensitivity and specificity of the newly established panCoV RT-PCR assay were 100%. 400 avian fecal (RNA) samples were further tested simultaneously for CoV by the new panCoV RT-PCR and a one-step RT-PCR assay with the δ-CoV nucleocapsid-specific universal primers. Four of 400 avian samples were positive for CoV, three of which were positive for δ-CoV by the conventional RT-PCR. PanCoV RT-PCR fragments for 3 of the 4 CoVs were sequenced. Phylogenetic analysis revealed the presence of one γ-CoV and two δ-CoV in the sequenced samples. The newly designed panCoV RT-PCR assay should be useful for the detection of currently known CoVs in animal biological samples. Copyright © 2018

Efficacy of Topical Therapy with Newly Developed Terbinafine and Econazole Formulations in the Treatment of Dermatophytosis in Cats.

Science.gov (United States)

Ivaskiene, M; Matusevicius, A P; Grigonis, A; Zamokas, G; Babickaite, L

2016-09-01

In the field of veterinary dermatology dermatophytosis is one of the most frequently occurring infectious diseases, therefore its treatment should be effective, convenient, safe and inexpensive. The aim of this study was to evaluate the efficacy of newly developed topical formulations in the treatment of cats with dermatophytosis. Evaluation of clinical efficacy and safety of terbinafine and econazole formulations administered topically twice a day was performed in 40 cats. Cats, suffering from the most widely spread Microsporum canis-induced dermatophytosis and treated with terbinafine hydrochloride 1% cream, recovered within 20.3±0.88 days; whereas when treated with econazole nitrate 1% cream, they recovered within 28.4±1.14 days. A positive therapeutic effect was yielded by combined treatment with local application of creams and whole coat spray with enilconazole 0.2% emulsion "Imaverol". Most cats treated with econazole cream revealed redness and irritation of the skin at the site of application. This study demonstrates that terbinafine tended to have superior clinical efficacy (p<0.001) in the treatment of dermatophytosis in cats compared to the azole tested.

Coping strategies among patients with newly diagnosed amyotrophic lateral sclerosis.

Science.gov (United States)

Jakobsson Larsson, Birgitta; Nordin, Karin; Askmark, Håkan; Nygren, Ingela

2014-11-01

To prospectively identify different coping strategies among newly diagnosed amyotrophic lateral sclerosis patients and whether they change over time and to determine whether physical function, psychological well-being, age and gender correlated with the use of different coping strategies. Amyotrophic lateral sclerosis is a fatal disease with impact on both physical function and psychological well-being. Different coping strategies are used to manage symptoms and disease progression, but knowledge about coping in newly diagnosed amyotrophic lateral sclerosis patients is scarce. This was a prospective study with a longitudinal and descriptive design. A total of 33 patients were included and evaluation was made at two time points, one to three months and six months after diagnosis. Patients were asked to complete the Motor Neuron Disease Coping Scale and the Hospital Anxiety and Depression Scale. Physical function was estimated using the revised Amyotrophic Lateral Sclerosis Functional Rating Scale. The most commonly used strategies were support and independence. Avoidance/venting and information seeking were seldom used at both time points. The use of information seeking decreased between the two time points. Men did not differ from women, but patients ≤64 years used positive action more often than older patients. Amyotrophic Lateral Sclerosis Functional Rating Scale was positively correlated with positive action at time point 1, but not at time point 2. Patients' psychological well-being was correlated with the use of different coping strategies. Support and independence were the most used coping strategies, and the use of different strategies changed over time. Psychological well-being was correlated with different coping strategies in newly diagnosed amyotrophic lateral sclerosis patients. The knowledge about coping strategies in early stage of the disease may help the nurses to improve and develop the care and support for these patients. © 2014 John Wiley

Understanding flexible and distributed software development processes

OpenAIRE

Agerfalk, Par J.; Fitzgerald, Brian

2006-01-01

peer-reviewed The minitrack on Flexible and Distributed Software Development Processes addresses two important and partially intertwined current themes in software development: process flexibility and globally distributed software development

Unified Approach in the DSS Development Process

Directory of Open Access Journals (Sweden)

2007-01-01

Full Text Available The structure of today's decision support environment become very complex due to new generation of Business Intelligence applications and technologies like Data Warehouse, OLAP (On Line Analytical Processing and Data Mining. In this respect DSS development process are not simple and needs an adequate methodology or framework able to manage different tools and platforms to achieve manager's requirements. The DSS development process must be view like a unified and iterative set of activities and operations. The new techniques based on Unified Process (UP methodology and UML (Unified Modeling Language it seems to be appropriate for DSS development using prototyping and RAD (Rapid Application Development techniques. In this paper we present a conceptual framework for development and integrate Decision Support Systems using Unified Process Methodology and UML.

A methodology for development of biocatalytic processes

DEFF Research Database (Denmark)

Lima Ramos, Joana

are available. The first case study presents a rational approach for defining a development strategy for multi-enzymatic processes. The proposed methodology requires a profound and structured knowledge of the multi-enzyme systems, integrating chemistry, biological and process engineering. In order to suggest......). These process metrics can often be attained by improvements in the reaction chemistry, the biocatalyst, and/or by process engineering, which often requires a complex process development strategy. Interestingly this complexity, which arises from the need for integration of biological and process technologies...... and their relationship with the overall process is not clear.The work described in this thesis presents a methodological approach for early stage development of biocatalytic processes, understanding and dealing with the reaction, biocatalyst and process constraints. When applied, this methodology has a decisive role...

Effect of mulching systems on fruit quality and phytochemical composition of newly developed strawberry lines

Directory of Open Access Journals (Sweden)

Li Fan

2012-06-01

Full Text Available The effects of three mulching systems on total yield, average yield per plant, average fruit weight, soluble solids content (SSC, titratable acidity (TA, firmness and oxygen radical absorbance capacity (ORAC of two newly developed lines (‘Orléans’ and ‘Saint Pierre’, one advanced selection (‘SJ8976-1’ and two commonly used cultivars (‘Jewel’ and ‘Kent’ were evaluated. The studied mulching systems were: plastic mulch (PM, mulch with row cover (PMRC, and matted-row system (MRS. Results showed that plastic mulch with row cover (PMRC generally increased yield per plant, average fruit weight, SSC, firmness and ORAC, but differences varied within harvest times. No significant differences in total yield and TA were observed under the selected mulching systems. Both PMRC and PM accelerated the harvest periods compared to MRS. ‘Kent’ and ‘Jewel’ had the highest total yield while ‘SJ8976-1’ and ‘St-Pierre’ had the highest average fruit weight. The highest SSC, TA and ORAC were found in ‘Jewel’. There was no interaction between the mulching systems and genotypes, indicating that the effect of production system is independent of cultivars. PMRC seems to be a better growing system, improving fruit quality and increasing the nutritional value of all genotypes. By allowing off-season fruit production in cool climates, PMRC can be an alternative method to the costly high tunnels.

Application of newly developed Fluoro-QC software for image quality evaluation in cardiac X-ray systems.

Science.gov (United States)

Oliveira, M; Lopez, G; Geambastiani, P; Ubeda, C

2018-05-01

A quality assurance (QA) program is a valuable tool for the continuous production of optimal quality images. The aim of this paper is to assess a newly developed automatic computer software for image quality (IR) evaluation in fluoroscopy X-ray systems. Test object images were acquired using one fluoroscopy system, Siemens Axiom Artis model (Siemens AG, Medical Solutions Erlangen, Germany). The software was developed as an ImageJ plugin. Two image quality parameters were assessed: high-contrast spatial resolution (HCSR) and signal-to-noise ratio (SNR). The time between manual and automatic image quality assessment procedures were compared. The paired t-test was used to assess the data. p Values of less than 0.05 were considered significant. The Fluoro-QC software generated faster IQ evaluation results (mean = 0.31 ± 0.08 min) than manual procedure (mean = 4.68 ± 0.09 min). The mean difference between techniques was 4.36 min. Discrepancies were identified in the region of interest (ROI) areas drawn manually with evidence of user dependence. The new software presented the results of two tests (HCSR = 3.06, SNR = 5.17) and also collected information from the DICOM header. Significant differences were not identified between manual and automatic measures of SNR (p value = 0.22) and HCRS (p value = 0.46). The Fluoro-QC software is a feasible, fast and free to use method for evaluating imaging quality parameters on fluoroscopy systems. Copyright © 2017 The College of Radiographers. Published by Elsevier Ltd. All rights reserved.

Possible origin of Saturn's newly discovered outer ring

International Nuclear Information System (INIS)

Moehlmann, D.

1986-01-01

Within a planetogonic model the self-gravitationally caused formation of pre-planetary and pre-satellite rings from an earlier thin disk is reported. The theoretically derived orbital radii of these rings are compared with the orbital levels in the planetary system and the satellite systems of Jupiter, Saturn and Uranus. From this comparison it is concluded that at the radial position of Saturn's newly discovered outer ring an early pre-satellite ring of more or less evolved satellites could have existed. These satellites should have been disturbed in their evolution by the gravitation of the neighbouring massive satellite Titan. The comparison also may indicate similarities between the asteroidal belt and the newly discovered outer ring of Saturn

Oral Cancer Knowledge Assessment: Newly Graduated versus Senior Dental Clinicians

Science.gov (United States)

Salgado de Souza, Ricardo; Gallego Arias Pecorari, Vanessa; Lauria Dib, Luciano

2018-01-01

The present study assessed the level of dentists' knowledge regarding oral cancer in the city of São Paulo, Brazil. A questionnaire was used to compare the level of knowledge among newly graduated and senior clinicians. A total of 20,154 e-mails were correctly delivered to the dentists registered in the database of the Regional Dentistry Council of São Paulo, and 477 (2.36%) responses were received. This sample consisted of 84 newly graduated clinicians and 105 senior clinicians. For the statistical analysis, the chi-square test and the logistic regression analysis were performed with α = 0.05, and the results were described herein. According to their knowledge level, the results were statistically different between the groups, since 19% of the newly graduated clinicians were evaluated with knowledge grade A (excellent) in comparison to 6.7% of the senior clinicians. In spite of the results indicated that newly graduated clinicians' knowledge regarding oral cancer was 2.1 times higher, 34.5% of the professionals in this group had regular or poor knowledge on the subject, and several questions relating to clinical characteristics and risk factors indicated that there still exist some knowledge gaps, demonstrating that there is a need for further studies and information activities addressing oral cancer. PMID:29666649

Quantification of Fusarium oxysporum in fumigated soils by a newly developed real-time PCR assay to assess the efficacy of fumigants for Fusarium wilt disease in strawberry plants.

Science.gov (United States)

Li, Yuan; Mao, Liangang; Yan, Dongdong; Ma, Taotao; Shen, Jin; Guo, Meixia; Wang, Qiuxia; Ouyang, Canbin; Cao, Aocheng

2014-11-01

Two soil fumigants, chloropicrin (CP) and dimethyl disulfide (DMDS), were used to control Fusarium wilt disease (FWD) which caused large economic losses in strawberries. The fumigants were evaluated alone and in combination in a laboratory study and in strawberry greenhouses. Laboratory tests found that combinations of CP and DMDS indicated a positive synergistic activity on Fusarium oxysporum. A newly developed quantitative assay for F. oxysporum involving real-time PCR was used successfully to evaluate F. oxysporum control by the fumigants; it provided similar results to the selective medium but was less time-consuming and less labor intensive. Greenhouse trials revealed that the combination of CP and DMDS successfully suppressed the incidence of FWD and sharply reduced the population density of F. oxysporum, which significantly increased fruit branch number and maintained a good strawberry yield, higher than methyl bromide (MB) treatment. All of the treatments provided significantly better results than the non-treated control. This study confirms that the newly developed real-time PCR quantitative assay for F. oxysporum was suitable for the control efficacy evaluation of soil fumigants and that the novel fumigant combination of CP and DMDS offers a promising effective alternative to MB for the control of F. oxysporum in strawberry greenhouses. © 2013 Society of Chemical Industry.

EUV mask process specifics and development challenges

Science.gov (United States)

Nesladek, Pavel

2014-07-01

EUV lithography is currently the favorite and most promising candidate among the next generation lithography (NGL) technologies. Decade ago the NGL was supposed to be used for 45 nm technology node. Due to introduction of immersion 193nm lithography, double/triple patterning and further techniques, the 193 nm lithography capabilities was greatly improved, so it is expected to be used successfully depending on business decision of the end user down to 10 nm logic. Subsequent technology node will require EUV or DSA alternative technology. Manufacturing and especially process development for EUV technology requires significant number of unique processes, in several cases performed at dedicated tools. Currently several of these tools as e.g. EUV AIMS or actinic reflectometer are not available on site yet. The process development is done using external services /tools with impact on the single unit process development timeline and the uncertainty of the process performance estimation, therefore compromises in process development, caused by assumption about similarities between optical and EUV mask made in experiment planning and omitting of tests are further reasons for challenges to unit process development. Increased defect risk and uncertainty in process qualification are just two examples, which can impact mask quality / process development. The aim of this paper is to identify critical aspects of the EUV mask manufacturing with respect to defects on the mask with focus on mask cleaning and defect repair and discuss the impact of the EUV specific requirements on the experiments needed.

Activation of a remote (1-year old) emotional memory interferes with the retrieval of a newly formed hippocampus-dependent memory in rats.

Science.gov (United States)

Zoladz, Phillip R; Woodson, James C; Haynes, Vernon F; Diamond, David M

2010-01-01

The persistent intrusion of remote traumatic memories in people with post-traumatic stress disorder (PTSD) may contribute to the impairment of their ongoing hippocampal and prefrontal cortical functioning. In the current work, we have developed a rodent analogue of the intrusive memory phenomenon. We studied the influence of the activation of a remote traumatic memory in rats on their ability to retrieve a newly formed hippocampus-dependent memory. Adult male Sprague-Dawley rats were given inhibitory avoidance (IA) training, and then 24 h or 1, 6 or 12 months later, the same rats were trained to learn, and then remember across a 30-min delay period, the location of a hidden escape platform in the radial-arm water maze (RAWM). When IA-trained rats spent the 30-min delay period in the IA apparatus, they exhibited intact remote (1-year old) memory of the shock experience. More importantly, activation of the rats' memory of the shock experience profoundly impaired their ability to retrieve the newly formed spatial memory of the hidden platform location in the RAWM. Our finding that reactivation of a remote emotional memory exerted an intrusive effect on new spatial memory processing in rats provides a novel approach toward understanding how intrusive memories of traumatic experiences interfere with ongoing cognitive processing in people with PTSD.

Career Motivation in Newly Licensed Registered Nurses: What Makes Them Remain

Science.gov (United States)

Banks, Zarata Mann; Bailey, Jessica H.

2010-01-01

Despite vast research on newly licensed registered nurses (RNs), we don't know why some newly licensed registered nurses remain in their current jobs and others leave the nursing profession early in their career. Job satisfaction, the most significant factor emerging from the literature, plays a significant role in nurses' decisions to remain in…

Features of the Manufacturing Vision Development Process

DEFF Research Database (Denmark)

Dukovska-Popovska, Iskra; Riis, Jens Ove; Boer, Harry

2005-01-01

of action research. The methodology recommends wide participation of people from different hierarchical and functional positions, who engage in a relatively short, playful and creative process and come up with a vision (concept) for the future manufacturing system in the company. Based on three case studies......This paper discusses the key features of the process of Manufacturing Vision Development, a process that enables companies to develop their future manufacturing concept. The basis for the process is a generic five-phase methodology (Riis and Johansen, 2003) developed as a result of ten years...... of companies going through the initial phases of the methodology, this research identified the key features of the Manufacturing Vision Development process. The paper elaborates the key features by defining them, discussing how and when they can appear, and how they influence the process....

Orienting and Onboarding Clinical Nurse Specialists: A Process Improvement Project.

Science.gov (United States)

Garcia, Mayra G; Watt, Jennifer L; Falder-Saeed, Karie; Lewis, Brennan; Patton, Lindsey

Clinical nurse specialists (CNSs) have a unique advanced practice role. This article describes a process useful in establishing a comprehensive orientation and onboarding program for a newly hired CNS. The project team used the National Association of Clinical Nurse Specialists core competencies as a guide to construct a process for effectively onboarding and orienting newly hired CNSs. Standardized documents were created for the orientation process including a competency checklist, needs assessment template, and professional evaluation goals. In addition, other documents were revised to streamline the orientation process. Standardizing the onboarding and orientation process has demonstrated favorable results. As of 2016, 3 CNSs have successfully been oriented and onboarded using the new process. Unique healthcare roles require special focus when onboarding and orienting into a healthcare system. The use of the National Association of Clinical Nurse Specialists core competencies guided the project in establishing a successful orientation and onboarding process for newly hired CNSs.

PREVALENCE OF DIABETIC RETINOPATHY IN PATIENTS WITH NEWLY DIAGNOSED TYPE II DIABETES MELLITUS

Directory of Open Access Journals (Sweden)

A. Bostak

2006-11-01

Full Text Available Diabetic retinopathy is a common complication of type II diabetes mellitus and carries with it the threat of blindness. Accurate information regarding the incidence of diabetic retinopathy and associated risk factors is important in the prevention of its development and of the visual impairment caused by this complication. This study was designed to determine the prevalence of diabetic retinopathy in newly diagnosed patients with type II diabetes mellitus. We have also evaluated the association of diabetic retinopathy with clinical and biochemical variables. In a cross-sectional study, 152 consecutive patients with newly diagnosed type II diabetes mellitus were referred from two outpatient clinics in Tehran for ophthalmologic exam to detect retinopathy. Indirect ophthalmoscopy was performed and data regarding risk factors were extracted from routine medical records. Chi square and Mann Whitney U tests were used to analyze the data. The overall prevalence of diabetic retinopathy was 13.8 %( 21 cases: three cases with microaneurysm only, 10 with mild, 5 with moderate and 2 with severe non proliferative diabetic retinopathy. Only one patient had advanced proliferative retinopathy. The prevalence of diabetic retinopathy was positively associated with age, duration of disease, fasting plasma glucose, HbA1c, and systolic blood pressure. Diabetic retinopathy is common in newly diagnosed type II diabetes mellitus patients. Ophthalmologic consultation is essential at the time of diagnosis for all patients.

Technology development life cycle processes.

Energy Technology Data Exchange (ETDEWEB)

Beck, David Franklin

2013-05-01

This report and set of appendices are a collection of memoranda originally drafted in 2009 for the purpose of providing motivation and the necessary background material to support the definition and integration of engineering and management processes related to technology development. At the time there was interest and support to move from Capability Maturity Model Integration (CMMI) Level One (ad hoc processes) to Level Three. As presented herein, the material begins with a survey of open literature perspectives on technology development life cycles, including published data on %E2%80%9Cwhat went wrong.%E2%80%9D The main thrust of the material presents a rational expose%CC%81 of a structured technology development life cycle that uses the scientific method as a framework, with further rigor added from adapting relevant portions of the systems engineering process. The material concludes with a discussion on the use of multiple measures to assess technology maturity, including consideration of the viewpoint of potential users.

Adapting the unified software development process for user interface development

NARCIS (Netherlands)

Obrenovic, Z.; Starcevic, D.

2006-01-01

In this paper we describe how existing software developing processes, such as Rational Unified Process, can be adapted in order to allow disciplined and more efficient development of user interfaces. The main objective of this paper is to demonstrate that standard modeling environments, based on the

Meeting and activating the newly unemployed

DEFF Research Database (Denmark)

Rotger, Gabriel Pons

-demanding activity. As intensive activation is usually accompanied by intensive search monitoring, it is important to disentangling the contribution of the costly activation programs from that of caseworker meetings. Using Danish data for the period 2010-13, the paper shows that requiring newly unemployed intensive...... activation, contrary to job search meetings, reduces employment and increases sickness benefit claims....

Safety guides development process in Spain

International Nuclear Information System (INIS)

Butragueno, J.L.; Perello, M.

1979-01-01

Safety guides have become a major factor in the licensing process of nuclear power plants and related nuclear facilities of the fuel cycle. As far as the experience corroborates better and better engineering methodologies and procedures, the results of these are settled down in form of standards, guides, and similar issues. This paper presents the actual Spanish experience in nuclear standards and safety guides development. The process to develop a standard or safety guide is shown. Up to date list of issued and on development nuclear safety guides is included and comments on the future role of nuclear standards in the licensing process are made. (author)

Robot development for nuclear material processing

International Nuclear Information System (INIS)

Pedrotti, L.R.; Armantrout, G.A.; Allen, D.C.; Sievers, R.H. Sr.

1991-07-01

The Department of Energy is seeking to modernize its special nuclear material (SNM) production facilities and concurrently reduce radiation exposures and process and incidental radioactive waste generated. As part of this program, Lawrence Livermore National Laboratory (LLNL) lead team is developing and adapting generic and specific applications of commercial robotic technologies to SNM pyrochemical processing and other operations. A working gantry robot within a sealed processing glove box and a telerobot control test bed are manifestations of this effort. This paper describes the development challenges and progress in adapting processing, robotic, and nuclear safety technologies to the application. 3 figs

Bioorthogonal Chemistry for the Isolation and Study of Newly Synthesized Histones and Their Modifications.

Science.gov (United States)

Arnaudo, Anna M; Link, A James; Garcia, Benjamin A

2016-03-18

The nucleosome is an octamer containing DNA wrapped around one histone H3-H4 tetramer and two histone H2A-H2B dimers. Within the nucleosome, histones are decorated with post-translational modifications. Previous studies indicate that the H3-H4 tetramer is conserved during DNA replication, suggesting that old tetramers serve as a template for the modification of newly synthesized tetramers. Here, we present a method that merges bioorthogonal chemistry with mass spectrometry for the study of modifications on newly synthesized histones in mammalian cells. HeLa S3 cells are dually labeled with the methionine analog azidohomoalanine and heavy (13)C6,(15)N4 isotope labeled arginine. Heavy amino acid labeling marks newly synthesized histones while azidohomoalanine incorporation allows for their isolation using bioorthogonal ligation. Labeled mononucleosomes were covalently linked via a copper catalyzed reaction to a FLAG-GGR-alkyne peptide, immunoprecipitated, and subjected to mass spectrometry for quantitative modification analysis. Mononucleosomes containing new histones were successfully isolated using this approach. Additionally, the development of this method highlights the potential deleterious effects of azidohomoalanine labeling on protein PTMs and cell cycle progression, which should be considered for future studies utilizing bioorthogonal labeling strategies in mammalian cells.

Quality of life in newly diagnosed children with specific learning disabilities (SpLD) and differences from typically developing children: a study of child and parent reports.

Science.gov (United States)

Ginieri-Coccossis, M; Rotsika, V; Skevington, S; Papaevangelou, S; Malliori, M; Tomaras, V; Kokkevi, A

2013-07-01

Research on quality of life (QoL) of school children with specific learning disabilities (SpLD) and their parents is scarce. The present study explores QoL deficits in newly diagnosed children with SpLD and their parents, in comparison to a similar age group of typically developing children. Possible associations between parental and child QoL were statistically explored in both groups of children. 70 newly diagnosed children with SpLD [International Classification of Diseases-10 (ICD-10) criteria] (38 boys, 32 girls, mean age 10.1 years) and a control group of 69 typically developing children of the same age (40 boys, 29 girls, mean age 10.6 years) were recruited. Children were of normal intelligence quotient, attending mainstream schools. Their parents were also recruited so a child's scores could be associated with corresponding parental scores (mother or father). Children's QoL was assessed by the German questionnaire for measuring quality of life in children and adolescents (KINDL(R) ) questionnaire and parental QoL by World Health Organization Quality of Life brief questionnaire (WHOQOL-BREF) of the World Health Organization. Children with SpLD in comparison to typically developing children reported according to the KINDL(R) measurement poorer emotional well-being, lower self-esteem and satisfaction in their relationships with family and friends. Surprisingly, school functioning was not reported by these children as an area of concern. Parents of children with SpLD indicated experiencing lower satisfaction in the WHOQOL-BREF domains of social relationships and environment. Correlational and regression analysis with parental-child QoL scores provided evidence that in the SpLD group, parental scores on WHOQOL-BREF social relationships and psychological health domains could be predictors of the child's emotional well-being, satisfaction with family, friends and school functioning. Stepwise regression analysis verified the effect of parents' WHOQOL-BREF social

An Experimental Study on Dynamics of a Novel Dual-Belt Continuous Variable Transmission Based on a Newly Developed Test Rig

Directory of Open Access Journals (Sweden)

Pak Kin Wong

2015-01-01

Full Text Available A novel dual-belt Van Doorne’s continuous variable transmission (DBVCVT system, which is applicable to heavy-duty vehicles, has been previously proposed by the authors in order to improve the low torque capacity of traditional single-belt CVT. This DBVCVT is a novel design among continuously variable transmissions and is necessary to be prototyped for experimental study, and the analytical dynamic model for this DBVCVT also needs to be experimentally validated. So, this work originally fabricated a prototype of DBVCVT and integrates this prototype to a light-load hardware-in-the-loop test rig by replacing the engine and load equipment with the AC motor and magnetic powder dynamometer. Moreover, with the use of this newly developed test rig, this work implements the experimental study of this DBVCVT for the first time. The comparison of experimental and simulation results validates the previously proposed analytical model for DBVCVT, and some basic characteristics of the DBVCVT in terms of the reliability, speed ratio, and transmission efficiency are also experimentally studied. In all, this developed test rig with the analytical model lays the foundation for further study on this novel DBVCVT.

Test beam evaluation of newly developed n-in-p planar pixel sensors for use in a high radiation environment

Energy Technology Data Exchange (ETDEWEB)

Kimura, K., E-mail: kimihiko@hep.phys.titech.ac.jp [Institute of Science and Engineering, Tokyo Institute of Technology, Ookayama 2-12-1, Meguro-ku, Tokyo 152-8551 (Japan); Yamaguchi, D.; Motohashi, K. [Institute of Science and Engineering, Tokyo Institute of Technology, Ookayama 2-12-1, Meguro-ku, Tokyo 152-8551 (Japan); Nakamura, K.; Unno, Y. [Institute of Particle and Nuclear Study, KEK, Oho 1-1, Tsukuba, Ibaraki 305-0801 (Japan); Jinnouchi, O. [Institute of Science and Engineering, Tokyo Institute of Technology, Ookayama 2-12-1, Meguro-ku, Tokyo 152-8551 (Japan); Altenheiner, S. [Experimentelle Physik IV, Technische Universität Dortmund, 44221 Dortmund (Germany); Blue, A. [School of Physics and Astronomy, University of Glasgow, Glasgow, G12 8QQ, Scotland (United Kingdom); Bomben, M. [CNRS/IN2P3 (France); Laboratoire de physique nucléaire et de hautes energies (LPNHE), Univ. Paris-UMPC, 4 Place Jussieu, 75005 Paris (France); Univ. Paris Diderot (France); Butter, A. [LAL, University Paris-Sud (France); CNRS/IN2P3 (France); Université Paris-Saclay, Orsay (France); Cervelli, A. [Universität Bern, Laboratory for High Energy Physics, Sidlerstrasse 55, CH-3012 Bern (Switzerland); Crawley, S. [School of Physics and Astronomy, University of Glasgow, Glasgow, G12 8QQ, Scotland (United Kingdom); Ducourthial, A. [CNRS/IN2P3 (France); Laboratoire de physique nucléaire et de hautes energies (LPNHE), Univ. Paris-UMPC, 4 Place Jussieu, 75005 Paris (France); Univ. Paris Diderot (France); Gisen, A. [Experimentelle Physik IV, Technische Universität Dortmund, 44221 Dortmund (Germany); Hagihara, M. [Institute of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8751 (Japan); and others

2016-09-21

Radiation-tolerant n-in-p planar pixel sensors have been under development in cooperation with Hamamatsu Photonics K.K. (HPK). This is geared towards applications in high-radiation environments, such as for the future Inner Tracker (ITk) placed in the innermost part of the ATLAS detector in the high luminosity LHC (HL-LHC) experiment. Prototypes of those sensors have been produced, irradiated, and evaluated over the last few years. In the previous studies, it was reported that significant drops in the detection efficiency were observed after irradiation, especially under bias structures. The bias structures are made up of poly-Si or Al bias rails and poly-Si bias resistors. The structure is implemented on the sensors to allow quality checks to be performed before the bump-bonding process, and to ensure that charge generated in floating pixels due to non-contacting or missing bump-bonds is dumped in a controlled way in order to avoid noise. To minimize the efficiency drop, several new pixel structures have been designed with bias rails and bias resistors relocated. Several test beams have been carried out to evaluate the drops in the detection efficiency of the new sensor structures after irradiation. Newly developed sensor modules were irradiated with proton-beams at the Cyclotron and Radio-Isotope Center (CYRIC) in Tohoku University to see the effect of sensor-bulk damage and surface charge-up. An irradiation with γ-rays was also carried out at Takasaki Advanced Radiation Research Center, with the goal of decoupling the effect of surface charge-up from that of bulk damage. Those irradiated sensors have been evaluated with particle beams at DESY and CERN. Comparison between different sensor structures confirmed significant improvements in minimizing efficiency loss under the bias structures after irradiation. The results from γ-irradiation also enabled cross-checking the results of a semiconductor technology simulation program (TCAD). - Highlights: • The

Clinical heterogeneity in newly diagnosed Parkinson's disease

NARCIS (Netherlands)

Post, Bart; Speelman, Johannes D.; de Haan, Rob J.

2008-01-01

OBJECTIVE: To determine clinical heterogeneity in newly diagnosed Parkinson's disease using cluster analysis and to describe the subgroups in terms of impairment, disability, perceived quality of life, and use of dopaminergic therapy. METHODS: We conducted a k-means cluster analysis in a prospective

The development and impact of active learning strategies on self-confidence in a newly designed first-year self-care pharmacy course - outcomes and experiences.

Science.gov (United States)

Smith, Kathryn J; Grundmann, Oliver; Li, Robin Moorman

2018-04-01

The primary objective of this investigation was to determine the effectiveness of different active learning exercises in a newly-designed flipped-classroom self-care course in applying newly acquired knowledge of self-care and improving the confidence of first-year pharmacy students to recommend self-care treatments and counsel patients. The early development of these skills is essential for the subsequent Community Introductory Pharmacy Practice Experience (CIPPE). An unpaired anonymous survey was administered to students, pre- and post-course, to ascertain their opinions on the effectiveness of various teaching strategies and active learning exercises on learning and on their confidence in treatment-planning and patient counseling for self-care patients. Comparison between pre- and post-course Likert scores was conducted using a one-way ANOVA followed by a post-hoc Tukey's test with significance at p = 0.05. All other tests of significance were conducted using a student's t-test with significance at p = 0.05. Students' self-confidence in developing treatment plans and in counseling for non-prescription drugs and dietary supplements significantly improved from the beginning to the end of this self-care course. The response rate was high in both the pre- (N = 208, 88.1%) and post- (N = 198, 83.9%) course surveys. The positive change in confidence was not reflected in increased performance on the final exam represented by a lower average score than the midterm exam. Active learning sessions and the flipped classroom approach in this first-year pharmacy self-care course contributed to increased self-confidence in making recommendations and counseling patients on proper use of nonprescription medications and dietary supplements. Copyright © 2017 Elsevier Inc. All rights reserved.

Process Fragment Libraries for Easier and Faster Development of Process-based Applications

Directory of Open Access Journals (Sweden)

David Schumm

2011-01-01

Full Text Available The term “process fragment” is recently gaining momentum in business process management research. We understand a process fragment as a connected and reusable process structure, which has relaxed completeness and consistency criteria compared to executable processes. We claim that process fragments allow for an easier and faster development of process-based applications. As evidence to this claim we present a process fragment concept and show a sample collection of concrete, real-world process fragments. We present advanced application scenarios for using such fragments in development of process-based applications. Process fragments are typically managed in a repository, forming a process fragment library. On top of a process fragment library from previous work, we discuss the potential impact of using process fragment libraries in cross-enterprise collaboration and application integration.

Electrochemical development of particle tracks in CR-39 polymer dosimeter

International Nuclear Information System (INIS)

Hadlock, D.E.; Parkhurst, M.A.; Yang, C.S.; Groeger, J.; Johnson, J.R.; Huang, S.J.

1985-09-01

Electrochemical etching of CR-39 polymeric track etch neutron detectors results in proton-recoil tracks can be distinguished from background tracks much better than tracks developed solely by chemical etching. A newly designed and constructed electrochemical etching apparatus allows large numbers of dosimeters to be processed simultaneously with consistent results. Many processing systems have been developed for chemical and electrochemical etching of the track etch dosimeters. Three systems specifically show great promise and are being studied extensively

[Principles of nutrition in patients with newly appointed stoma].

Science.gov (United States)

Pachocka, Lucyna Małgorzata; Urbanik, Anna

2016-01-01

The treatment of intestinal stoma is often a difficult experience for patients and results in numerous problems in the physical, psychological and social aspects. Therefore, post-operative care of the patient with the newly appointed stoma should be taken by therapeutic team consisting of doctors, nurses, physiotherapists, dieticians, psychologists and social workers. Appropriate nutritional education of patients aims to improve their quality of life and to prevent from unpleasant ailments formed after the operation. The specific type of stoma may decide about certain dietary recommendations. The presented work provides a practical dietary recommendations for patients with newly appointed stoma.

Dynamic plan modelling and visualization : converting an urban development plan into a transition scenario

NARCIS (Netherlands)

Vries, de B.; Jessurun, A.J.; Sadowski - Rasters, G.; Tidafy, T; Dorta, T

2009-01-01

Application of 3D models in urban planning practice is still limited to visualization of existing or newly designed situations. Municipalities are looking for possibilities to communicate the transition process of the urban development area with the citizens. A prototype system was developed to

Two Newly Discovered Plants in Taiwan

OpenAIRE

Tian-Chuan Hsu; Jia-Jung Lin; Shih-Wen Chung

2009-01-01

Two herbs are newly discovered in Taiwan. Limnophila fragrans (G. Forst.) Seem. (Scrophulariaceae), native in SE Asia, is recognized from southern lowlands. Anagallis minima (L.) E. H. L. Krause (Primulaceae), native in N America and Europe, was found from northern mountainous region at low altitudes. In this study, descriptions, line drawings, color photos and a distribution map of the two species are provided.

Heuristics for batching and sequencing in batch processing machines

Directory of Open Access Journals (Sweden)

Chuda Basnet

2016-12-01

Full Text Available In this paper, we discuss the “batch processing” problem, where there are multiple jobs to be processed in flow shops. These jobs can however be formed into batches and the number of jobs in a batch is limited by the capacity of the processing machines to accommodate the jobs. The processing time required by a batch in a machine is determined by the greatest processing time of the jobs included in the batch. Thus, the batch processing problem is a mix of batching and sequencing – the jobs need to be grouped into distinct batches, the batches then need to be sequenced through the flow shop. We apply certain newly developed heuristics to the problem and present computational results. The contributions of this paper are deriving a lower bound, and the heuristics developed and tested in this paper.

New product development processes for ICT-for-development projects

CSIR Research Space (South Africa)

McAlister, BN

2012-08-01

Full Text Available in developing regions of the world is increasing rapidly. A number of methods and practices have been used by organizations to develop and deliver such ICT solutions, but a need exists to formalize product development processes for use in the ICT...

Evaluation of edge enhancement effect of phase contrast imaging using newly-developed photostimulable phosphor plate

International Nuclear Information System (INIS)

Matsuo, Satoru; Morishita, Junji; Katafuchi, Tetsuro; Fujita, Hiroshi

2012-01-01

We investigated whether the use of a newly developed columnar-crystal-type photostimulable-phosphor plate (CP1M200, referred to as system C) helps to provide improved edge-enhanced effect in phase contrast imaging. Physical characteristics of 2 conventional particulate-crystal-type photostimulable-phosphor plates (RP-5PM, referred to as system A and RP-6M, referred to as system B) and system C were measured. Then, an acrylic plate phantom and RMI152 phantom were imaged using 3 types of plates, and the edge-enhancement effects were evaluated based on the profile curve of the acrylic plate phantom. Visual evaluation of the RMI152 phantom images was conducted. The results showed that the modulation transfer function (MTF) of system C was superior to those of the other systems. The WS of system C was superior to those of the other systems in the low frequency band region, and inferior to those of the other systems in the high frequency band region. The presence of an edge-enhanced image was not detectable in the profile curve of the acrylic plate in system A, although that was shown in systems B and C due to their excellent sharpness. In the visual image evaluation of the RMI152 phantom, image quality of system C was superior to those of the other systems. Phase contrast imaging with a digital detector of a columnar-crystal-type photostimulable-phosphor plate is considered to provide improved edge-enhancement over that of conventional plates. (author)

Newly developed liquid-based cytology. TACAS™: cytological appearance and HPV testing using liquid-based sample.

Science.gov (United States)

Kubushiro, Kaneyuki; Taoka, Hideki; Sakurai, Nobuyuki; Yamamoto, Yasuhiro; Kurasaki, Akiko; Asakawa, Yasuyuki; Iwahara, Minoru; Takahashi, Kei

2011-09-01

Cell profiles determined by the thin-layer advanced cytology assay system (TACAS™), a liquid-based cytology technique newly developed in Japan, were analyzed in this study. Hybrid capture 2 (HC-2) was also performed using the liquid-based samples prepared by TACAS to ascertain its ability to detect human papillomavirus (HPV). Cell collection samples from uterine cervix were obtained from 359 patients and examined cytologically. A HC-2 assay for HPV was carried out in the cell specimens. All specimens were found to show background factors such as leukocytes. After excluding the 5 unsatisfactory cases from the total 354 cases, 82 cases (23.2%) were positive and 272 cases (76.8%) were negative for HPV. Cell specimens from 30 HPV-positive cases and 166 HPV-negative cases were subjected to 4 weeks of preservation at room temperature. Then, when subsequently re-assayed, 28 cases (93.3%) in the former group were found to be HPV positive and 164 cases (98.8%) in the latter group were found to be HPV negative. These results supported the excellent reproducibility of TACAS for HPV testing. A reasonable inference from the foregoing analysis is that TACAS may be distinguished from other liquid-based cytological approaches, such as ThinPrep and SurePath, in that it can retain the cell backgrounds. Furthermore, this study raises the possibility that cell specimens prepared using TACAS could be preserved for at least 4 weeks prior to carrying out a HC-2 assay for HPV.

Photoexcitation dynamics in solution-processed formamidinium lead iodide perovskite thin films for solar cell applications

NARCIS (Netherlands)

Fang, Hong-Hua; Wang, Feng; Adjokatse, Sampson; Zhao, Ni; Even, Jacky; Loi, Maria Antonietta

Formamidinium lead iodide (FAPbI(3)) is a newly developed hybrid perovskite that potentially can be used in high-efficiency solution-processed solar cells. Here, the temperature-dependent dynamic optical properties of three types of FAPbI(3) perovskite films (fabricated using three different

Pollen parameters estimates of genetic variability among newly ...

African Journals Online (AJOL)

Pollen parameters estimates of genetic variability among newly selected Nigerian roselle (Hibiscus sabdariffa L.) genotypes. ... Estimates of some pollen parameters where used to assess the genetic diversity among ... HOW TO USE AJOL.

Tricks of the trade: time management tips for newly qualified doctors.

Science.gov (United States)

Offiah, Gozie; Doherty, Eva

2018-03-01

The transition from medical student to doctor is an important milestone. The discovery that their time is no longer their own and that the demands of their job are greater than the time they have available is extremely challenging. At a recent surgical boot camp training programme, 60 first-year surgical trainees who had just completed their internship were invited to reflect on the lessons learnt regarding effective time management and to recommend tips for their newly qualified colleagues. They were asked to identify clinical duties that were considered urgent and important using the time management matrix and the common time traps encountered by newly qualified doctors. The surgical trainees identified several practical tips that ranged from writing a priority list to working on relationships within the team. These tips are generic and so applicable to all newly qualified medial doctors. We hope that awareness of these tips from the outset as against learning them through experience will greatly assist newly qualified doctors. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Development of interface technology between unit processes in E-Refining process

Energy Technology Data Exchange (ETDEWEB)

Lee, S. H.; Lee, H. S.; Kim, J. G. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2010-10-15

The pyroprocessing is composed mainly four subprocesses, such as an electrolytic reduction, an electrorefining, an electrowinning, and waste salt regeneration/ solidification processes. The electrorefining process, one of main processes which are composed of pyroprocess to recover the useful elements from spent fuel, is under development by Korea Atomic Energy Research Institute as a sub process of pyrochemical treatment of spent PWR fuel. The CERS(Continuous ElectroRefining System) is composed of some unit processes such as an electrorefiner, a salt distiller, a melting furnace for the U-ingot and U-chlorinator (UCl{sub 3} making equipment) as shown in Fig. 1. In this study, the interfaces technology between unit processes in E-Refining system is investigated and developed for the establishment of integrated E-Refining operation system as a part of integrated pyroprocessing

Development of hybrid artificial intelligent based handover decision algorithm

Directory of Open Access Journals (Sweden)

A.M. Aibinu

2017-04-01

Full Text Available The possibility of seamless handover remains a mirage despite the plethora of existing handover algorithms. The underlying factor responsible for this has been traced to the Handover decision module in the Handover process. Hence, in this paper, the development of novel hybrid artificial intelligent handover decision algorithm has been developed. The developed model is made up of hybrid of Artificial Neural Network (ANN based prediction model and Fuzzy Logic. On accessing the network, the Received Signal Strength (RSS was acquired over a period of time to form a time series data. The data was then fed to the newly proposed k-step ahead ANN-based RSS prediction system for estimation of prediction model coefficients. The synaptic weights and adaptive coefficients of the trained ANN was then used to compute the k-step ahead ANN based RSS prediction model coefficients. The predicted RSS value was later codified as Fuzzy sets and in conjunction with other measured network parameters were fed into the Fuzzy logic controller in order to finalize handover decision process. The performance of the newly developed k-step ahead ANN based RSS prediction algorithm was evaluated using simulated and real data acquired from available mobile communication networks. Results obtained in both cases shows that the proposed algorithm is capable of predicting ahead the RSS value to about ±0.0002 dB. Also, the cascaded effect of the complete handover decision module was also evaluated. Results obtained show that the newly proposed hybrid approach was able to reduce ping-pong effect associated with other handover techniques.

Chest Radiographic Findings in Newly Diagnosed Pulmonary ...

African Journals Online (AJOL)

Five hundred newly diagnosed cases of Pulmonary Tuberculosis were treated with directly observed short-course treatment and 100 of them had chest radiographic examination done. The various chest radiographic patterns in the 100 subjects were studied and included: Fluffy exudative changes 80(80%), fibrosis 70(70%) ...

New developments in online plant monitoring

International Nuclear Information System (INIS)

Laipple, Bernd; Langenstein, Magnus

2007-01-01

The large quantities of information produced within plant processes nearly make the plausibility of data impossible without the help of additional tools. For this reason, a variety of plant monitoring tools has been developed in the past which promise a sensible compression of data. The main problem with the offered tools lies with the omission of procedural plausibility. The newly developed plant monitoring system BTB ProcessPlus is based on the VDI 2048 methodology of process data reconciliation. Plausibility and quality control therefore serve as a basis for the system. With this procedural process image, significant diagnosis and monitoring tools have been developed and now offer a fast and economically optimal support in process optimization. This paper describes the methodology according to VDI 2048. The benefits of the online plant monitoring system are demonstrated by means of examples from day-to-day operations. (author)

Validating self-reported mobile phone use in adults using a newly developed smartphone application.

Science.gov (United States)

Goedhart, Geertje; Kromhout, Hans; Wiart, Joe; Vermeulen, Roel

2015-11-01

Interpretation of epidemiological studies on health effects from mobile phone use is hindered by uncertainties in the exposure assessment. We used a newly developed smartphone application (app) to validate self-reported mobile phone use and behaviour among adults. 107 participants (mean age 41.4 years) in the Netherlands either downloaded the software app on their smartphone or were provided with a study smartphone for 4 weeks. The app recorded the number and duration of calls, text messages, data transfer, laterality and hands-free use. Self-reported mobile phone use was collected before using the app and after 6 months through an interviewer-administered questionnaire. The geometric mean ratios (GMR, 95% CI) and Spearman correlations (r) of self-reported (after 6 months) versus recorded number and duration of calls were: GMR=0.65 (0.53 to 0.80), r=0.53; and GMR=1.11 (0.86 to 1.42), r=0.57 respectively. Participants held the phone on average for 86% of the total call time near the head. Self-reported right side users held the phone for 70.7% of the total call time on the right side of the head, and left side users for 66.2% on the left side of the head. The percentage of total call time that the use of hands-free devices (headset, speaker mode, Bluetooth) was recorded increased with increasing frequency of reported hands-free device usage. The observed recall errors and precision of reported laterality and hands-free use can be used to quantify and improve radiofrequency exposure models based on self-reported mobile phone use. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Application of the newly developed Japanese adenosine normal database for adenosine stress myocardial scintigraphy.

Science.gov (United States)

Harata, Shingo; Isobe, Satoshi; Morishima, Itsuro; Suzuki, Susumu; Tsuboi, Hideyuki; Sone, Takahito; Ishii, Hideki; Murohara, Toyoaki

2015-10-01

The currently available Japanese normal database (NDB) in stress myocardial perfusion scintigraphy recommended by the Japanese Society of Nuclear Medicine (JSNM-NDB) is created based on the data from exercise tests. The newly developed adenosine normal database (ADS-NDB) remains to be validated for patients undergoing adenosine stress test. We tested whether the diagnostic accuracy of adenosine stress test is improved by the use of ADS-NDB (Kanazawa University). Of 233 consecutive patients undergoing (99m)Tc-MIBI adenosine stress test, 112 patients were tested. The stress/rest myocardial (99m)Tc-MIBI single-photon emission computed tomography (SPECT) images were analyzed by AutoQUANT 7.2 with both ADS-NDB and JSNM-NDB. The summed stress score (SSS) and summed difference score (SDS) were calculated. The agreements of the post-stress defect severity between ADS-NDB and JSNM-NDB were assessed using a weighted kappa statistic. In all patients, mean SSSs of all, right coronary artery (RCA), left anterior descending (LAD), and left circumflex (LCx) territories were significantly lower with ADS-NDB than those with JSNM-NDB. Mean SDSs in all, RCA, and LAD territories were significantly lower with ADS-NDB than those with JSNM-NDB. In 28 patients with significant coronary stenosis, the mean SSS in the RCA territory was significantly lower with ADS-NDB than that with JSNM-NDB. In 84 patients without ischemia, both mean SSSs and SDSs in all, RCA, LAD, and LCx territories were significantly lower with ADS-NDB than those with JSNM-NDB. Weighted kappa values of all patients, patients with significant stenosis, and patients without ischemia were 0.89, 0.83, and 0.92, respectively. Differences were observed between results from ADS-NDB and JSNM-NDB. The diagnostic accuracy of adenosine stress myocardial perfusion scintigraphy may be improved by reducing false-positive results.

Preparation and Evaluation of Newly Developed Chitosan Salt Coating Dispersions for Colon Delivery without Requiring Overcoating.

Science.gov (United States)

Yamada, Kyohei; Iwao, Yasunori; Bani-Jaber, Ahmad; Noguchi, Shuji; Itai, Shigeru

2015-01-01

Although chitosan (CS) has been recognized as a good material for colon-specific drug delivery systems, an overcoating with an enteric coating polymer on the surface of CS is absolutely necessary because CS is soluble in acidic conditions before reaching the colon. In the present study, to improve its stability in the presence of acid, a newly developed CS-laurate (CS-LA) material was evaluated as a coating dispersion for the development of colon-specific drug delivery systems. Two types of CS with different molecular weights, CS250 and CS600, were used to prepare CS-LA films by the casting method. The CS250-LA films had smooth surfaces, whereas the surfaces of the CS600-LA films were rough, indicating that the CS250-LA dispersion could form a denser film than CS600-LA. Both of these CS-LA films maintained a constant shape over 22 h in a pH 1.2 HCl/NaCl buffer, where the corresponding CS films rapidly disintegrated. In addition, the CS250-LA film showed specific colon degradability in a pH 6.0 phosphate buffered solution containing 1.0% (w/v) β-glucosidase. As a result of tensile strength and elongation at the break, both CS-LA films were found to have flexible film properties. Finally, the release of acetaminophen from disks coated with CS250-LA dispersions was significantly suppressed in fluids at pH 1.2 and 6.8, whereas disks coated with CS solution rapidly released the drug in pH 1.2 fluids. Taken together, this study shows that LA modification could be a useful approach in preparing CS films with acid stability and colonic degradability properties without requiring overcoating.

Development process of subjects society

Directory of Open Access Journals (Sweden)

A. V. Reshetnichenko

2014-08-01

Full Text Available Background due to defining the role of people in the development of society and the almost complete absence of scientific management processes capable of progressive development of both individuals and social communities, and nations, and civilization in general. In order to overcome inherent subjectivist methodology of knowledge, psyholohizatorskyh, hiperpolityzovanyh and utilitarian approach, the authors proposed a three-tier system of business processes of society. The conceptual core of the approach consists in the detection task as logical - mathematical laws of subjects of primary, secondary and higher levels of development, and on the mechanisms of their formation and practice. The solution of the tasks allowed the authors to reveal the structure of both the ascending and descending processes of economic society. Thus, the analysis of individual carriers upward changes as «individual», «individuality», «person» and «personality» showed conditionality determination of their activities with «anthropometric», «ethnic», «demographic» and «ideological» mechanisms. Nature as common carriers downstream changes revealed using correlative related «groups», «group «, «groups» and «communities» whose activity is due to «vitalistic», «education», «professional» and «stratification» mechanisms. To disclose the nature and organization of secondary and higher levels of economic society by the authors introduced the category of «citizen», «heneralista», «human space», «human galactic» ‘formation and development is causing «status», «Persona logical», «humanocentric», «institutional», «cluster», «kontaminatsiyni» and other mechanisms. One of the main achievements of the work, the authors consider the possibility of further development and practical implementation of new quality management processes of economic society based multimodal dialectical logic.

EXPERIMENTAL INVESTIGATION OF THE ORTHO/PARA RATIO OF NEWLY FORMED MOLECULAR HYDROGEN ON AMORPHOUS SOLID WATER

International Nuclear Information System (INIS)

Gavilan, L.; Lemaire, J. L.; Dulieu, F.; Congiu, E.; Chaabouni, H.; Vidali, G.; Chehrouri, M.; Fillion, J.-H.

2012-01-01

Several astronomical observations have shown that the ortho/para ratio (OPR) of H 2 can differ from the expected statistical value of 3 or the local thermodynamic equilibrium (LTE) value at the gas or dust temperature. It is thus important to know the OPR of H 2 newly formed on dust grain surfaces, in order to clarify the dependence of the observed OPR in space on the formation process. Using an experimental setup designed to mimic interstellar medium environments, we measured the OPR of H 2 and D 2 formed on the surface of porous amorphous water ice held at 10 K. We report for the first time the OPR value for newly formed D 2 , consistent with the expected LTE value at the high-temperature limit found by previous theoretical and experimental works on the determination of the OPR upon H 2 formation on surfaces at low temperature.

Integrating ergonomics into the product development process

DEFF Research Database (Denmark)

Broberg, Ole

1997-01-01

and production engineers regarding information sources in problem solving, communication pattern, perception of ergonomics, motivation and requests to support tools and methods. These differences and the social and organizational contexts of the development process must be taken into account when considering......A cross-sectional case study was performed in a large company producing electro-mechanical products for industrial application. The purpose was to elucidate conditions and strategies for integrating ergonomics into the product development process thereby preventing ergonomic problems at the time...... of manufacture of new products. In reality the product development process is not a rational problem solving process and does not proceed in a sequential manner as decribed in engineering models. Instead it is a complex organizational process involving uncertainties, iterative elements and negotiation between...

Two Newly Discovered Plants in Taiwan

Directory of Open Access Journals (Sweden)

Tian-Chuan Hsu

2009-11-01

Full Text Available Two herbs are newly discovered in Taiwan. Limnophila fragrans (G. Forst. Seem. (Scrophulariaceae, native in SE Asia, is recognized from southern lowlands. Anagallis minima (L. E. H. L. Krause (Primulaceae, native in N America and Europe, was found from northern mountainous region at low altitudes. In this study, descriptions, line drawings, color photos and a distribution map of the two species are provided.

Diabetes education and self-management for ongoing and newly diagnosed (DESMOND)

DEFF Research Database (Denmark)

Skinner, T. Chas; Carey, Marian E.; Cradock, Sue

2006-01-01

diagnosed with Type 2 diabetes changes key illness beliefs and that these changes predict quality of life and metabolic control at 3-month follow-up. Practice implications: Newly diagnosed individuals are open to attending self-management programs and, if the program is theoretically driven, can......Objective: To determine the effects of a structured education program on illness beliefs, quality of life and physical activity in people newly diagnosed with Type 2 diabetes. Methods: Individuals attending a diabetes education and self-management for ongoing and newly diagnosed (DESMOND) program...... in 12 Primary Care Trusts completed questionnaire booklets assessing illness beliefs and quality of life at baseline and 3-month follow-up, metabolic control being assessed through assay of HbA1c. Results: Two hundred and thirty-six individuals attended the structured self-management education sessions...

Model for Simulating a Spiral Software-Development Process

Science.gov (United States)

Mizell, Carolyn; Curley, Charles; Nayak, Umanath

2010-01-01

A discrete-event simulation model, and a computer program that implements the model, have been developed as means of analyzing a spiral software-development process. This model can be tailored to specific development environments for use by software project managers in making quantitative cases for deciding among different software-development processes, courses of action, and cost estimates. A spiral process can be contrasted with a waterfall process, which is a traditional process that consists of a sequence of activities that include analysis of requirements, design, coding, testing, and support. A spiral process is an iterative process that can be regarded as a repeating modified waterfall process. Each iteration includes assessment of risk, analysis of requirements, design, coding, testing, delivery, and evaluation. A key difference between a spiral and a waterfall process is that a spiral process can accommodate changes in requirements at each iteration, whereas in a waterfall process, requirements are considered to be fixed from the beginning and, therefore, a waterfall process is not flexible enough for some projects, especially those in which requirements are not known at the beginning or may change during development. For a given project, a spiral process may cost more and take more time than does a waterfall process, but may better satisfy a customer's expectations and needs. Models for simulating various waterfall processes have been developed previously, but until now, there have been no models for simulating spiral processes. The present spiral-process-simulating model and the software that implements it were developed by extending a discrete-event simulation process model of the IEEE 12207 Software Development Process, which was built using commercially available software known as the Process Analysis Tradeoff Tool (PATT). Typical inputs to PATT models include industry-average values of product size (expressed as number of lines of code

Nuclear material accounting and control: Co-ordinating assistance to newly independent States

International Nuclear Information System (INIS)

Thorstensen, S.

1995-01-01

This article outlines work under way among the IAEA, its Member States, and the Newly Independent States (NIS) relating to the establishment and development in the NIS of State Systems of Accounting and Control (SSACs) of nuclear material. It describes IAEA activities in the NIS, including fact-finding missions at technical visits, the successful attempts to find donor States providing voluntary funding and expertise, and the co-ordination of technical support between the IAEA and the donor States. 3 tabs

Software Development Standard Processes (SDSP)

Science.gov (United States)

Lavin, Milton L.; Wang, James J.; Morillo, Ronald; Mayer, John T.; Jamshidian, Barzia; Shimizu, Kenneth J.; Wilkinson, Belinda M.; Hihn, Jairus M.; Borgen, Rosana B.; Meyer, Kenneth N.;

Extending the agile development process to develop acceptably secure software

NARCIS (Netherlands)

Ben Othmane, L.; Angin, P.; Weffers, H.T.G.; Bhargava, B.

2013-01-01

The agile software development approach makes developing secure software challenging. Existing approaches for extending the agile development process, which enables incremental and iterative software development, fall short of providing a method for efficiently ensuring the security of the software

Image processing in radiology

International Nuclear Information System (INIS)

Dammann, F.

2002-01-01

Medical imaging processing and analysis methods have significantly improved during recent years and are now being increasingly used in clinical applications. Preprocessing algorithms are used to influence image contrast and noise. Three-dimensional visualization techniques including volume rendering and virtual endoscopy are increasingly available to evaluate sectional imaging data sets. Registration techniques have been developed to merge different examination modalities. Structures of interest can be extracted from the image data sets by various segmentation methods. Segmented structures are used for automated quantification analysis as well as for three-dimensional therapy planning, simulation and intervention guidance, including medical modelling, virtual reality environments, surgical robots and navigation systems. These newly developed methods require specialized skills for the production and postprocessing of radiological imaging data as well as new definitions of the roles of the traditional specialities. The aim of this article is to give an overview of the state-of-the-art of medical imaging processing methods, practical implications for the ragiologist's daily work and future aspects. (orig.) [de

Profiles of alpha-melanocyte-stimulating hormone in the Japanese flounder as revealed by a newly developed time-resolved fluoroimmunoassay and immunohistochemistry.

Science.gov (United States)

Amiya, Noriko; Amano, Masafumi; Takahashi, Akiyoshi; Yamanome, Takeshi; Yamamori, Kunio

2007-03-01

Profiles of alpha-melanocyte-stimulating hormone (alpha-MSH) in the Japanese flounder were examined by a newly developed time-resolved fluoroimmunoassay (TR-FIA) and immunohistochemistry. A TR-FIA for alpha-MSH was newly developed, and its levels in the pituitary gland and plasma of Japanese flounder reared in a white or black tank for 5 months were compared. A competitive assay using two antibodies was performed among secondary antibodies in the solid phase, alpha-MSH antibodies, samples, and europium-labeled Des-Ac-alpha-MSH. The sensitivity of the assay, defined as twice the standard deviation at a zero dose, was 0.98 ng/ml (49 pg/well). The intra- and interassay coefficients of variation of the assay were 8.8% (n=8) and 17.3% (n=5), respectively, at about 50% binding. Cross-reactivities of Des-Ac-alpha-MSH and Di-Ac-alpha-MSH were about 100%. Cross-reactivities of adrenocorticotropic hormone, salmon gonadotropin-releasing hormone (sGnRH), and chicken GnRH-II were less than 0.2%, and that of melanin-concentrating hormone was less than 2.0% at 50% binding. Displacement curves of serially twofold-diluted hypothalamus extract, pituitary gland extract, and plasma extract of Japanese flounder with the assay buffer were parallel to the alpha-MSH standard curve. Moreover, displacement curves of serially twofold-diluted hypothalamus and/or pituitary gland extract of masu salmon, goldfish, red seabream, Japanese eel, tiger puffer, and barfin flounder with the assay buffer were also parallel to the alpha-MSH standard. In Japanese flounder, total immunoreactive (ir)-alpha-MSH levels in the pituitary gland were lower in the black tank, whereas those in the plasma tended to be higher in the black tank, suggesting that the synthesis and release of alpha-MSH are higher in the black tank. alpha-MSH-ir cells were detected in the pars intermedia and a small part of the pars distalis of the pituitary gland. alpha-MSH-ir cell bodies were located in the basal hypothalamus and alpha

Innovative IPV from attenuated Sabin poliovirus or newly designed alternative seed strains.

Science.gov (United States)

Hamidi, Ahd; Bakker, Wilfried A M

2012-11-01

This article gives an overview of the patent literature related to innovative inactivated polio vaccine (i-IPV) based on using Sabin poliovirus strains and newly developed alternative recombinant poliovirus strains. This innovative approach for IPV manufacturing is considered to attribute to the requirement for affordable IPV in the post-polio-eradication era, which is on the horizon. Although IPV is a well-established vaccine, the number of patent applications in this field was seen to have significantly increased in the past decade. Currently, regular IPV appears to be too expensive for universal use. Future affordability may be achieved by using alternative cell lines, alternative virus seed strains, improved and optimized processes, dose sparing, or the use of adjuvants. A relatively short-term option to achieve cost-price reduction is to work on regular IPV, using wild-type poliovirus strains, or on Sabin-IPV, based on using attenuated poliovirus strains. This price reduction can be achieved by introducing efficiency in processing. There are also multiple opportunities to work on dose sparing, for example, by using adjuvants or fractional doses. Renewed interest in this field was clearly reflected in the number and diversity of patent applications. In a later stage, several innovative approaches may become even more attractive, for example the use of recombinant virus strains or even a totally synthetic vaccine. Currently, such work is mainly carried out by research institutes and universities and therefore clinical data are not available.

Process developments in gasoil hydrotreating

Energy Technology Data Exchange (ETDEWEB)

Lawrence, R.C.; Kinley, D.H.; Wood, M.A. [Davy Process Technology Limited, London (United Kingdom)

1997-07-01

Changing demand patterns and legislation increase the pressure upon hydrotreating capacities at many refineries. To meet these pressures, improvements have been and will be necessary not only in catalysts, but also in the hydrotreating process. On the basis of its hydrogenation experience, Davy Process Technology has developed and tested a number of concepts aimed at improving the effectiveness of the basic process - enabling economic deep desulfurisation and opening up the potential for an integrated HDS/HDA flowsheet using sulphur tolerant HDA Catalysts.

'Practising under your own Pin'- a description of the transition experiences of newly qualified midwives.

Science.gov (United States)

Avis, Mark; Mallik, Maggie; Fraser, Diane M

2013-11-01

Transition experiences of newly qualified midwives were examined in depth during the third phase of a UK evaluation study of midwifery education. The fitness to practise and the retention of newly qualified nursing and midwifery graduates are pressing concerns for health care managers. The advantages of preceptorship are reported in the literature but the content and timing of schemes remain unclear. A semi-structured diary was kept for up to 6 months by 35 newly qualified midwives in 18 work sites covering all countries in the UK. The preceptor and supervisor of midwives for each newly qualified midwife completed short questionnaires about their preceptee's performance, and a further sub-sample of newly qualified midwives and preceptors participated in a semi-structured interview. Data were analysed to elicit aspects of newly qualified midwives transition experiences. Findings confirm that structured preceptorship schemes are not widely available. Newly qualified midwives primarily obtained transition support from members of the midwifery team. Although perceived as competent, there is no demarcation point in becoming confident to practise as a registered practitioner. Implications for managers include the importance of a supportive culture within clinical teams for successful transition and the introduction of structured preceptorship schemes facilitated by appropriate rotation patterns. © 2012 John Wiley & Sons Ltd.

Music-based Autism Diagnostics (MUSAD) - A newly developed diagnostic measure for adults with intellectual developmental disabilities suspected of autism.

Science.gov (United States)

Bergmann, Thomas; Sappok, Tanja; Diefenbacher, Albert; Dames, Sibylle; Heinrich, Manuel; Ziegler, Matthias; Dziobek, Isabel

2015-01-01

The MUSAD was developed as a diagnostic observational instrument in an interactional music framework. It is based on the ICD-10/DSM-5 criteria for autism spectrum disorder (ASD) and was designed to assess adults on a lower level of functioning, including individuals with severe language impairments. This study aimed to evaluate the psychometric properties of the newly developed instrument. Calculations were based on a consecutive clinical sample of N=76 adults with intellectual and developmental disabilities (IDD) suspected of ASD. Objectivity, test-retest reliability, and construct validity were calculated and a confirmatory factor analysis was applied to verify a reduced and optimized test version. The structural model showed a good fit, while internal consistency of the subscales was excellent (ω>.92). Item difficulties ranged between .04≤pi≤.82 and item-total correlation from .21 to .85. Objectivity was assessed by comparing the scorings of two external raters based on a subsample of n=12; interrater agreement was .71 (ICC 2, 1). Reliability was calculated for four test repetitions: the average ICC (3, 1) was .69. Convergent ASD measures correlated significantly with the MUSAD, while the discriminant Modified Overt Aggression Scale (MOAS) showed no significant overlap. Confirmation of factorial structure and acceptable psychometric properties suggest that the MUSAD is a promising new instrument for diagnosing ASD in adults with IDD. Copyright © 2015 Elsevier Ltd. All rights reserved.

Advances in the Process Development of Biocatalytic Processes

DEFF Research Database (Denmark)

Tufvesson, Pär; Lima Ramos, Joana; Al-Haque, Naweed

2013-01-01

Biocatalysis is already established in chemical synthesis on an industrial scale, in particular in the pharmaceutical sector. However, the wider implementation of biocatalysis is currently hindered by the extensive effort required to develop a competitive process. In order that resources spent...

The use of EORTC measures in daily clinical practice-A synopsis of a newly developed manual.

Science.gov (United States)

Wintner, Lisa M; Sztankay, Monika; Aaronson, Neil; Bottomley, Andrew; Giesinger, Johannes M; Groenvold, Mogens; Petersen, Morten Aa; van de Poll-Franse, Lonneke; Velikova, Galina; Verdonck-de Leeuw, Irma; Holzner, Bernhard

2016-11-01

Cancer has increasingly become a chronic condition and the routine collection of patient-reported outcomes (PROs) like quality of life is widely recommended for clinical practice. Nonetheless, the successful implementation of PROs is still a major challenge, although common barriers to and facilitators of their beneficial use are well known. To support health care professionals and other stakeholders in the implementation of the EORTC PRO measures, the EORTC Quality of Life Group provides guidance on issues considered important for their use in daily clinical practice. Herein, we present an outline of the newly developed "'Manual for the use of EORTC measures in daily clinical practice", covering the following issues: * a rationale for using EORTC measures in routine care *selection of EORTC measures, timing of assessments, scoring and presentation of results * aspects of a strategic implementation * electronic data assessment and telemonitoring, and * further use of EORTC measures and ethical considerations. Next to an extensive overview of currently available literature, the manual specifically focuses on knowledge about EORTC measures to give evidence-based recommendations whenever possible and to encourage readers and end-users of EORTC measures to contribute to further needed high-quality research. The manual will be accessible on the EORTC Quality of Life Group website's homepage and will be periodically updated to take into account any new knowledge due to medical, technical, regulatory and scientific advances. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

Yield and Adaptability Evaluation of Newly Introduced Tomato ...

African Journals Online (AJOL)

High yield is a major ambition to tomato plant breeders and farmers. The purpose of the ... Tabora Region on the growth and yield of newly introduced tomato varieties. The tested ..... (1985). Evaluation of some American tomatocultivars grown.

Newly elected IAEA Board of Governors

International Nuclear Information System (INIS)

2000-01-01

The document gives information about the election of 11 Member States to the IAEA Board of Governors, the 35-member policy-making body, during the 44th regular session of the IAEA's General Conference (18 - 22 September 2000, Austria Center, Vienna). The newly elected Member States are: Argentina, Egypt, Ghana, Ireland, Libyan Arab Jamahiriya, Mexico, Pakistan, Peru, Switzerland, Thailand, Ukraine. The other 24 Member States of the Board are also given

Development of DUMAS data processing system

International Nuclear Information System (INIS)

Sakamoto, Hiroshi

1982-01-01

In the field of nuclear experiments, the speed-up of data processing has been required recently along with the increase of the amount of data per event or the rate of event occurrence per unit time. In the DUMAS project of RCNP, the development of data processing system has been required, which can perform the high speed transfer and processing. The system should transfer the data of 5 multiwire proportional counters and other counters from the laboratory to the counting room at the rate of 1000 events every second, and also should perform considerably complex processes such as histogramming, particle identification, calculation of various polarizations as well as dumping to the secondary memory in the counting room. Furthermore, easy start-up, adjustment, inspection and maintenance and non-special hardware and software should be considered. A system presently being investigated for satisfying the above requirements is described. The main points are as follows: to employ CAMAC system for the interface with readout circuit, to transfer data between the laboratory and the counting room by converting the byte-serial transfer to the bit-serial optical fiber communication, and to unify the data processing computers to the PDP-11 family by connecting two miniature computers. Development of such a data processing system seems to be useful as an preparatory research for the development of NUMATRON measuring instruments. (Wakatsuki, Y.)

A subjective and objective fuzzy-based analytical hierarchy process model for prioritization of lean product development practices

Directory of Open Access Journals (Sweden)

Daniel O. Aikhuele

2017-06-01

Full Text Available In this paper, a subjective and objective fuzzy-based Analytical Hierarchy Process (AHP model is proposed. The model which is based on a newly defined evaluation matrix replaces the fuzzy comparison matrix (FCM in the traditional fuzzy AHP model, which has been found ineffective and time-consuming when criteria/alternatives are increased. The main advantage of the new model is that it is straightforward and completely eliminates the repetitive adjustment of data that is common with the FCM in traditional AHP model. The model reduces the complete dependen-cy on human judgment in prioritization assessment since the weights values are solved automati-cally using the evaluation matrix and the modified priority weight formula in the proposed mod-el. By virtue of a numerical case study, the model is successfully applied in the determination of the implementation priorities of lean practices for a product development environment and com-pared with similar computational methods in the literature.

Circulating mesencephalic astrocyte-derived neurotrophic factor is increased in newly diagnosed prediabetic and diabetic patients, and is associated with insulin resistance.

Science.gov (United States)

Wu, Tong; Zhang, Fang; Yang, Qiu; Zhang, Yuwei; Liu, Qinhui; Jiang, Wei; Cao, Hongyi; Li, Daigang; Xie, Shugui; Tong, Nanwei; He, Jinhan

2017-04-29

Evidence has shown that endoplasmic reticulum (ER) stress was involved in the progression to type 2 diabetes mellitus (T2DM) and development of insulin resistance. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a novel secreted protein upregulated by ER stress. This study aimed to assess serum level of MANF in normal glucose tolerance (NGT) participants and newly diagnosed prediabetic and T2DM patients. A total of 257 participants with NGT, newly diagnosed prediabetes or T2DM were recruited from Yinchao and Hangtian communities of Chengdu, Sichuan, China. Serum MANF level was quantified by enzyme-linked immunosorbent assay (ELISA). The mean age for the 257 participants (147 females) was 62±8 years (range 44-78): 71 with NGT, 115 with newly diagnosed prediabetes and 71 with T2DM. Mean serum MANF level was significantly higher with newly diagnosed prediabetes and T2DM than NGT (2.89±1.09 and 3.03±1.73 vs 2.13±1.37 ng/mL, both pprediabetes patients. We concluded that serum MANF level was higher in patients with newly diagnosed prediabetes and T2DM than in NGT controls. MANF appears to be associated with Matsuda Index, QUICKI and HOMA-IR in prediabetes patients.

Developments on uranium enrichment processes in France

International Nuclear Information System (INIS)

Frejacques, C.; Gelee, M.; Massignon, D.; Plurien, P.

1977-01-01

Gaseous diffusion has so far been the main source of supply for enriched uranium and it is only recently that the gas centrifuge came into the picture. Numerous other isotope separation processes have been considered or are being assessed, and there is nothing to exclude the future use of a new process. Developments on likely new processes have been carried out by many organizations both governmental and private. The French Commissariat a l'energie atomique, besides their very extensive endeavours already devoted to gaseous diffusion, have studied and developed the gas centrifuge, chemical exchange, aerodynamic and selective photoexcitation processes. The gaseous diffusion process, selected by Eurodif for the Tricastin plant, and which will also be used by Coredif, is discussed in another paper in these Proceedings. This process is the technico-economic yardstick on which our comparisons are based. Within the limits of their development level, processes are compared on the basis of the separative work cost components: specific investment, specific power consumption and power cost, and specific operating and maintenance costs. (author)

Localization of foot-and-mouth disease - RNA synthesis on newly formed cellular smooth membranous vacuoles

International Nuclear Information System (INIS)

Polatnick, J.; Wool, S.H.

1982-01-01

Viral RNA synthesis in foot-and-mouth disease infected bovine kidney cell cultures was associated throughout the infectious period with newly formed smooth membranous vacuoles. Membrane formation was measured by choline uptake. The site of RNA synthesis was determined by electron microscopic examination of autoradiograms of incorporated [ 3 H] uridine. Both membrane formation and RNA synthesis became signifcant at 2.5 hours postinfection, but membrane formation increased steadily to 4.5 hours while RNA synthesis peaked at 3.5 hours. Percent density distributions of developed silver grains on autoradiograms showed that almost all RNA synthesis was concentrated on the smooth vacuoles of infected cells. Histogram analysis of grain density distributions established that the site of RNA synthesis was the vacuolar membrane. The newly formed smooth membrane-bound vacuoles were not seen to coalesce into the large vacuolated areas typical of poliovirus cytopathogenicity. (Author)

Localization of foot-and-mouth disease - RNA synthesis on newly formed cellular smooth membranous vacuoles

Energy Technology Data Exchange (ETDEWEB)

Polatnick, J.; Wool, S.H. (United States Department of Agriculture, Science and Education, Greenport, New York (USA). Agricultural Research, Plum Island Animal Disease Center)

1982-01-01

Viral RNA synthesis in foot-and-mouth disease infected bovine kidney cell cultures was associated throughout the infectious period with newly formed smooth membranous vacuoles. Membrane formation was measured by choline uptake. The site of RNA synthesis was determined by electron microscopic examination of autoradiograms of incorporated (/sup 3/H) uridine. Both membrane formation and RNA synthesis became signifcant at 2.5 hours postinfection, but membrane formation increased steadily to 4.5 hours while RNA synthesis peaked at 3.5 hours. Percent density distributions of developed silver grains on autoradiograms showed that almost all RNA synthesis was concentrated on the smooth vacuoles of infected cells. Histogram analysis of grain density distributions established that the site of RNA synthesis was the vacuolar membrane. The newly formed smooth membrane-bound vacuoles were not seen to coalesce into the large vacuolated areas typical of poliovirus cytopathogenicity.

Assessment and Development of Engineering Design Processes

DEFF Research Database (Denmark)

Ulrikkeholm, Jeppe Bjerrum

, the engineering companies need to have efficient engineering design processes in place, so they can design customised product variants faster and more efficiently. It is however not an easy task to model and develop such processes. To conduct engineering design is often a highly iterative, illdefined and complex...... the process can be fully understood and eventually improved. Taking its starting point in this proposition, the outcome of the research is an operational 5-phased procedure for assessing and developing engineering design processes through integrated modelling of product and process, designated IPPM......, and eventually the results are discussed, overall conclusions are made and future research is proposed. The results produced throughout the research project are developed in close collaboration with the Marine Low Speed business unit within the company MAN Diesel & Turbo. The business unit is the world market...

Clinical evaluation of a newly designed orthodontic tooth brush - A clinical study

Directory of Open Access Journals (Sweden)

C S Saimbi

2009-01-01

In this study, the newly designed orthodontic tooth brush is compared with an ordinary tooth brush. Results of this study show that the newly designed orthodontic tooth brush is superior in its cleaning efficiency as compared to the ordinary tooth brush. The results show that plaque removing capacity of orthodontic tooth brush is nearly 95-99%.

Development of acidic processes for decontaminating LMFBR components

Energy Technology Data Exchange (ETDEWEB)

Hill, E F [Rockwell International, Atomics International Division, Canoga Park (United States); Colburn, R P; Lutton, J M; Maffei, H P [Hanford Engineering Development Laboratory, Richland (United States)

1978-08-01

The objective of the DOE decontamination program is to develop a well characterized chemical decontamination process for application to LMFBR primary system components that subsequently permits contact maintenance and allows requalification of the components for reuse in reactors. The paper describes the subtasks of deposit characterization, development of requalification and process acceptance criteria, development of process evaluation techniques and studies which led to a new acidic process for decontaminating 304 stainless steel hot leg components.

Development of acidic processes for decontaminating LMFBR components

International Nuclear Information System (INIS)

Hill, E.F.; Colburn, R.P.; Lutton, J.M.; Maffei, H.P.

1978-01-01

The objective of the DOE decontamination program is to develop a well characterized chemical decontamination process for application to LMFBR primary system components that subsequently permits contact maintenance and allows requalification of the components for reuse in reactors. The paper describes the subtasks of deposit characterization, development of requalification and process acceptance criteria, development of process evaluation techniques and studies which led to a new acidic process for decontaminating 304 stainless steel hot leg components

EXPERIMENTAL INVESTIGATION OF THE ORTHO/PARA RATIO OF NEWLY FORMED MOLECULAR HYDROGEN ON AMORPHOUS SOLID WATER

Energy Technology Data Exchange (ETDEWEB)

Gavilan, L.; Lemaire, J. L.; Dulieu, F.; Congiu, E.; Chaabouni, H. [LERMA, UMR 8112 du CNRS, de l' Observatoire de Paris et de l' Universite de Cergy Pontoise, 5 mail Gay Lussac, F-95000 Cergy Pontoise Cedex (France); Vidali, G. [Visiting Professor. Permanent address: Physics Department, Syracuse University, Syracuse, NY 13244-1320 (United States); Chehrouri, M. [Permanent address: LEPC Universite de Saida, BP138, ENSAR, 20002 Saida (Algeria); Fillion, J.-H., E-mail: lisseth.gavilan@obspm.fr [Permanent address: LPMAA, UMR 7092, Universite Pierre et Marie Curie, F-75252 Paris Cedex 05 (France)

2012-11-20

Several astronomical observations have shown that the ortho/para ratio (OPR) of H{sub 2} can differ from the expected statistical value of 3 or the local thermodynamic equilibrium (LTE) value at the gas or dust temperature. It is thus important to know the OPR of H{sub 2} newly formed on dust grain surfaces, in order to clarify the dependence of the observed OPR in space on the formation process. Using an experimental setup designed to mimic interstellar medium environments, we measured the OPR of H{sub 2} and D{sub 2} formed on the surface of porous amorphous water ice held at 10 K. We report for the first time the OPR value for newly formed D{sub 2}, consistent with the expected LTE value at the high-temperature limit found by previous theoretical and experimental works on the determination of the OPR upon H{sub 2} formation on surfaces at low temperature.

Controlling the Instructional Development Process. Training Development and Research Center Project Number Fifteen.

Science.gov (United States)

Sleezer, Catherine M.; Swanson, Richard A.

Process control is a way of training managers in business and industry to plan, monitor, and communicate the instructional development process of training projects. Two simple and useful tools that managers use in controlling the process of instructional development are the Process Control Planning Sheet and the Process Control Record. The Process…

Development of Industrial Process Diagnosis and Measurement Technology

International Nuclear Information System (INIS)

Jung, Sung Hee; Kim, Jong Bum; Moon, Jin Ho

2010-04-01

Section 1. Industrial Gamma CT Technology for Process Diagnosis: The project is aimed to develop industrial process gamma tomography system for investigation on structural and physical malfunctioning and process media distribution by means of sealed gamma source and radioactive materials. Section 2. Development of RI Hydraulic Detection Technology for Industrial Application: The objectives in this study are to develop the evaluation technology of the hydrological characteristics and the hydraulic detection technology using radioisotope, and to analyze the hydrodynamics and pollutant transport in water environment like surface and subsurface. Section 3. Development of RT-PAT System for Powder Process Diagnosis: The objective of this project is the development of a new radiation technology to improve the accuracy of the determination of moisture content in a powder sample by using radiation source through the so-called RT-PAT (Radiation Technology-Process Analytical Technology), which is a new concept of converging technology between the radiation technology and the process analytical technology

Development of industrial process diagnosis and measurement technology

International Nuclear Information System (INIS)

Jung, Sunghee; Kim, Jongbum; Moon, Jinho; Suh, Kyungsuk; Kim, Jongyun

2012-04-01

Section1. Industrial Gamma CT Technology for Process Diagnosis The project is aimed to develop industrial process gamma tomography system for investigation on structural and physical malfunctioning and process media distribution by means of sealed gamma source and radioactive materials. Section2. Development of RI Hydraulic Detection Technology for Industrial Application The objectives in this study are to develop the evaluation technology of the hydrological characteristics and the hydraulic detection technology using radioisotope, and to analyze the hydrodynamics and pollutant transport in water environment like surface and subsurface. Section3. Development of RT-PAT System for Powder Process Diagnosis The objective of this project is the development of a new radiation technology to improve the accuracy of the determination of moisture content in a powder sample by using radiation source through the so-called RT-PAT (Radiation Technology-Process Analytical Technology), which is a new concept of converging technology between the radiation technology and the process analytical technology

Development of coal partial hydropyrolysis process

Energy Technology Data Exchange (ETDEWEB)

Hideaki Yabe; Takafumi Kawamura; Kohichiroh Gotoh; Akemitsu Akimoto [Nippon Steel Corporation, Chiba (Japan)

2005-07-01

Coal partial hydropyrolysis process aims at co-production of high yield of light oil such as BTX and naphthalene and synthesis gas from a low rank coal under a mild hydropyrolysis condition. The characteristic of this process is in the two-staged entrained hydropyrolysis reactor composed of the reformer and gasifier. This reactor arrangement gives us high heat efficiency of this process. So far, in order to evaluate the process concept a small-scale basic experiment and a 1t/day process development unit study were carried out. The experimental results showed that coal volatiles were partially hydrogenated to increase the light oil and hydrocarbon gases at the condition of partial hydropyrolysis such as pressure of 2-3MPa, temperature of 700-900{sup o}C and hydrogen concentration of 30-50%. This process has a possibility of producing efficiently and economically liquid and gas products as chemicals and fuel for power generation. As a further development in the period of 2003 to 2008, a 20t/day pilot plant study named ECOPRO (efficient co-production with coal flash hydropyrolysis technology) has been started to establish the process technologies for commercialization. 12 refs., 6 figs., 3 tabs.

Use of farm waste biomass in the process of gasification for energy production

Energy Technology Data Exchange (ETDEWEB)

Piechocki, J. [Warmia and Mazury Univ., Olsztyn (Poland)

2010-07-01

The process of gasification of waste biomass from farm production was examined along with the energy balance of the process. A newly developed biomass gasification technology that uses manure from poultry farms as the input material was shown to meet all environmental requirements. The gas was purified in a membrane process to increase its calorific value. The gas was then used in an internal combustion engine powering a current generating system to produce electricity and heat in a combined heat and power system (CHP).

A Petri Net-Based Software Process Model for Developing Process-Oriented Information Systems

Science.gov (United States)

Li, Yu; Oberweis, Andreas

Aiming at increasing flexibility, efficiency, effectiveness, and transparency of information processing and resource deployment in organizations to ensure customer satisfaction and high quality of products and services, process-oriented information systems (POIS) represent a promising realization form of computerized business information systems. Due to the complexity of POIS, explicit and specialized software process models are required to guide POIS development. In this chapter we characterize POIS with an architecture framework and present a Petri net-based software process model tailored for POIS development with consideration of organizational roles. As integrated parts of the software process model, we also introduce XML nets, a variant of high-level Petri nets as basic methodology for business processes modeling, and an XML net-based software toolset providing comprehensive functionalities for POIS development.

Diabetes education improves depressive state in newly diagnosed patients with type 2 diabetes

OpenAIRE

Chen, Bin; Zhang, Xiyao; Xu, Xiuping; Lv, Xiaofeng; Yao, Lu; Huang, Xu; Guo, Xueying; Liu, Baozhu; Li, Qiang; Cui, Can

2013-01-01

Objectives: The prevalence of depression is relatively high in individuals with diabetes. However, screening and monitoring of depressive state in patients with diabetes is still neglected in developing countries and the treatment of diabetes-related depression is rarely performed in these countries. In this study, our aim was to study the role of diabetes education in the improvement of depressive state in newly diagnosed patients with type 2 diabetes. Methods: The Dutch version of the cente...

Brazilian dietary patterns and the dietary approaches to stop hypertension (DASH) diet-relationship with metabolic syndrome and newly diagnosed diabetes in the ELSA-Brasil study.

Science.gov (United States)

Drehmer, Michele; Odegaard, Andrew O; Schmidt, Maria Inês; Duncan, Bruce B; Cardoso, Letícia de Oliveira; Matos, Sheila M Alvim; Molina, Maria Del Carmen B; Barreto, Sandhi M; Pereira, Mark A

2017-01-01

Studies evaluating dietary patterns, including the DASH diet, and their relationship with the metabolic syndrome and diabetes may help to understand the role of dairy products (low fat or full fat) in these conditions. Our aim is to identify dietary patterns in Brazilian adults and compare them with the (DASH) diet quality score in terms of their associations with metabolic syndrome and newly diagnosed diabetes in the Brazilian Longitudinal Study of Adult Health-the ELSA-Brasil study. The ELSA-Brasil is a multicenter cohort study comprising 15,105 civil servants, aged 35-74 years at baseline (2008-2010). Standardized interviews and exams were carried out, including an OGTT. We analyzed baseline data for 10,010 subjects. Dietary patterns were derived by principal component analysis. Multivariable logistic regression investigated associations of dietary patterns with metabolic syndrome and newly diagnosed diabetes and multivariable linear regression with components of metabolic syndrome. After controlling for potential confounders, we observed that greater adherence to the Common Brazilian meal pattern (white rice, beans, beer, processed and fresh meats), was associated with higher frequencies of newly diagnosed diabetes, metabolic syndrome and all of its components, except HDL-C. Participants with greater intake of a Common Brazilian fast foods/full fat dairy/milk based desserts pattern presented less newly diagnosed diabetes. An inverse association was also seen between the DASH Diet pattern and the metabolic syndrome, blood pressure and waist circumference. Diet, light foods and beverages/low fat dairy pattern was associated with more prevalence of both outcomes, and higher fasting glucose, HDL-C, waist circumference (among men) and lower blood pressure. Vegetables/fruit dietary pattern did not protect against metabolic syndrome and newly diagnosed diabetes but was associated with lower waist circumference. The inverse associations found for the dietary pattern

Newly elected IAEA Board of Governors

International Nuclear Information System (INIS)

2001-01-01

The document gives information about the election of 11 Member States to the IAEA Board of Governors, the 35-member policy-making body, during the 45th regular session of the IAEA's General Conference (17-21 September 2001, Austria Center, Vienna). The newly elected Member States are: Bulgaria, Burkina Faso, Chile, Colombia, Islamic Republic of Iran, Kuwait, Morocco, Philippines, Romania, Spain, and Turkey. The other 24 Member States of the Board are also given

Health problems of newly arrived migrants and refugees in Europe.

Science.gov (United States)

Pavli, Androula; Maltezou, Helena

2017-07-01

The number of migrants and refugees in Europe in the past few years has increased dramatically due to war, violence or prosecutions in their homeland. Migration may affect physical, mental and social health. The objective of this article is to assess migrants and refugees' health problems, and to recommend appropriate interventions. A PubMed search of published articles on health problems of newly arrived migrants and refugees was conducted from 2003 through 2016, focusing on the current refugee crisis in Europe. In addition to communicable diseases, such as respiratory, gastrointestinal and dermatologic infections, non-communicable diseases, including chronic conditions, mental and social problems, account for a significant morbidity burden in newly arrived migrants and refugees. Vaccine-preventable diseases are also of outmost importance. The appropriate management of newly arrived refugees and migrants' health problems is affected by barriers to access to health care including legal, communication, cultural and bureaucratic difficulties. There is diversity and lack of integration regarding health care provision across Europe due to policy differences between health care systems and social services. There is a notable burden of communicable and non-communicable diseases among newly arrived migrants and refugees. Provision of health care at reception and temporary centres should be integrated and provided by a multidisciplinary team Appropriate health care of migrants and refugees could greatly enhance their health and social status which will benefit also the host countries at large. © International Society of Travel Medicine, 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

Key Features of the Manufacturing Vision Development Process

DEFF Research Database (Denmark)

Dukovska-Popovska, Iskra; Riis, Jens Ove; Boer, Harry

2005-01-01

of action research. The methodology recommends wide participation of people from different hierarchical and functional positions, who engage in a relatively short, playful and creative process and come up with a vision (concept) for the future manufacturing system in the company. Based on three case studies......This paper discusses the key features of the process of Manufacturing Vision Development, a process that enables companies to develop their future manufacturing concept. The basis for the process is a generic five-phase methodology (Riis and Johansen 2003) developed as a result of ten years...... of companies going through the initial phases of the methodology, this research identified the key features of the Manufacturing Vision Development process. The paper elaborates the key features by defining them, discussing how and when they can appear, and how they influence the process....

Itataia project - Development of the process

International Nuclear Information System (INIS)

Coelho, S.V.

1987-01-01

A process for treating the phosphorus uraniferous ore, from Itataia-CE mine in Brazil, was developed, establishing the basic flow chart for recovery two products: uranium concentrate and phosphoric acid. The developed process consists in physical concentration, chemical separation, solvent extraction, and it presented, in laboratory and pilot scales, recovery levels which assure the project viability technicaly and economicaly. The consolidation of project and the description of installations are presented by a documentary film. (M.C.K.) [pt

Itataia project - Development of the process

International Nuclear Information System (INIS)

Coelho, S.V.

1987-01-01

A process for treating the phosphorous uraniferous ore, from Itataia-CE mine in Brazil, was developed, establishing the basic flow chart for recovery two products: uranium concentrate and phosphoric acid. The developed process consists in physical concentration, chemical separation, solvent extraction, and it presented, in laboratory and pilot scales, recovery leves which assure the project viability technically and economically. The consolidation of project and the description of installations are presented by a documentary film. (M.C.K.) [pt

Elements in a new sustainable industrial culture - Environmental assessment in product development

DEFF Research Database (Denmark)

Alting, Leo; Hauschild, Michael Zwicky; Wenzel, Henrik

1997-01-01

In the last few years the environmental focus in the manufacturing industry has shifted from the manufacturing processes to the products themselves, as these are accountable for the environmental impacts in all life cycle phases. The paper describes for 3 industrial cases how a newly developed LCA...... methodology can assist the product developer in development of more environmentally friendly products. Finally, common experience gained will be discussed....

Management of Talent Development Process in Sport

OpenAIRE

SEVİMLİ, Dilek

2015-01-01

In the development of elite athletes, talent identification and education, is a complex and multidimensional process. It is difficult to predict the future performance depending on the increasing amount of technical, tactical, conditioning and psychological needs in a sport. Factors such as children’s developmental stages and levels, gender, athlete development programs, social support, the quality of coaches, access to equipment and facilities can affect talent development process.Phases of ...

Development and implementation of an HIV/AIDS trials management system: a geographical information systems approach

CSIR Research Space (South Africa)

Busgeeth, K

2008-01-01

Full Text Available of randomised and clinically controlled trials of HIV/AIDS interventions can provide invaluable information to decision-making processes. Using the newly emerging geographical information systems (GIS) technology, researchers have developed a tool which assists...

Adolescent Decision-Making Processes regarding University Entry: A Model Incorporating Cultural Orientation, Motivation and Occupational Variables

Science.gov (United States)

Jung, Jae Yup

2013-01-01

This study tested a newly developed model of the cognitive decision-making processes of senior high school students related to university entry. The model incorporated variables derived from motivation theory (i.e. expectancy-value theory and the theory of reasoned action), literature on cultural orientation and occupational considerations. A…

Radiation therapy of newly diagnosed, advanced prostatic cancer and hormonally relapsed prostatic cancer

International Nuclear Information System (INIS)

Suzuki, Minoru; Fujiwara, Kazuhisa; Hayakawa, Katsumi; Hida, Shuichi

1994-01-01

Ten patients with newly diagnosed, advanced prostatic cancer were treated with radiotherapy and hormone therapy to improve tumor control and survival. Eight patients with hormonally relapsed prostatic cancer were treated with radiotherapy to improve their quality of life. Local control of the tumor was achieved in 9 of 10 patients with newly diagnosed, advanced prostatic cancer. Five of eight patients with hormonally relapsed prostatic cancer obtained improved quality of life. Combined radiotherapy and hormone therapy were effective in the treatment of newly diagnosed, advanced prostatic cancer, and radiotherapy was useful for improving the quality of life of patients with hormonally relapsed prostatic cancer. (author)

Three Newly Naturalized Plants in Taiwan

Directory of Open Access Journals (Sweden)

Ming-Jer Jung

2009-11-01

Full Text Available Three newly naturalized plants are reported in this paper. Hypochaeris microcephala (Sch. Bip. Cabrera var. albiflora (Kuntze Cabrera (Asteraceae is naturalized in urban areas of northern Taiwan. Indigofera pseudo-tinctoria Matsum. (Leguminosae is naturalized in low elevations of northern and southern Taiwan and in middle elevations of central Taiwan. Lamium purpureum L. (Laminaceae has become naturalized locally in middle elevations of central Taiwan. Descriptions, illustrations and color photos of these plants are provided.

The $16,819 pay gap for newly trained physicians: the unexplained trend of men earning more than women.

Science.gov (United States)

Lo Sasso, Anthony T; Richards, Michael R; Chou, Chiu-Fang; Gerber, Susan E

2011-02-01

Prior research has suggested that gender differences in physicians' salaries can be accounted for by the tendency of women to enter primary care fields and work fewer hours. However, in examining starting salaries by gender of physicians leaving residency programs in New York State during 1999-2008, we found a significant gender gap that cannot be explained by specialty choice, practice setting, work hours, or other characteristics. The unexplained trend toward diverging salaries appears to be a recent development that is growing over time. In 2008, male physicians newly trained in New York State made on average $16,819 more than newly trained female physicians, compared to a $3,600 difference in 1999.

Integrating Usability Evaluations into the Software Development Process

DEFF Research Database (Denmark)

Lizano, Fulvio

as relevant and strategic human–computer interaction (HCI) activities in the software development process, there are obstacles that limit the complete, effective and efficient integration of this kind of testing into the software development process. Two main obstacles are the cost of usability evaluations...... and the software developers' resistance to accepting users’ opinions regarding the lack of usability in their software systems. The ‘cost obstacle’ refers to the constraint of conducting usability evaluations in the software process due to the significant amount of resources required by this type of testing. Some......This thesis addresses the integration of usability evaluations into the software development process. The integration here is contextualized in terms of how to include usability evaluation as an activity in the software development lifecycle. Even though usability evaluations are considered...

A Newly Developed Perfused Umbrella Electrode for Radiofrequency Ablation: An Ex Vivo Evaluation Study in Bovine Liver

International Nuclear Information System (INIS)

Bruners, Philipp; Pfeffer, Jochen; Kazim, Rana M.; Guenther, Rolf W.; Schmitz-Rode, Thomas; Mahnken, Andreas H.

2007-01-01

The purpose of this study was to evaluate the effectiveness of a newly developed perfused monopolar radiofrequency (RF) probe with an umbrella-shaped array. A perfused umbrella-shaped monopolar RF probe based on a LeVeen electrode (Boston Scientific Corp., Natick, MA, USA) with a 3-cm array diameter was developed. Five different configurations of this electrode were tested: (a) perfusion channel/endhole, (b) perfusion channel/endhole + sideholes, (c) 1 cm insulation removed at the tip, (d) 1 cm insulation removed at the tip + perfusion channel/endhole, and (e) 1 cm insulation removed at the tip + perfusion channel/endhole + sideholes. An unmodified LeVeen electrode served as a reference standard. RF ablations were performed in freshly excised bovine liver using a commercial monopolar RF system with a 200-W generator (RF 3000; Boston Scientific Corp.). Each electrode was tested 10 times applying the vendor's recommended ablation protocol combined with the preinjection of 2 ml 0.9% saline. Volumes and shapes of the lesions were compared. Lesions generated with the original LeVeen electrode showed a mean volume of 12.74 ± 0.52 cm 3 . Removing parts of the insulation led to larger coagulation volumes (22.65 ± 2.12 cm 3 ). Depending on the configuration, saline preinjection resulted in a further increase in coagulation volume (25.22 ± 3.37 to 31.28 ± 2.32 cm 3 ). Besides lesion volume, the shape of the ablation zone was influenced by the configuration of the electrode used. We conclude that saline preinjection in combination with increasing the active tip length of the umbrella-shaped LeVeen RF probe allows the reliable ablation of larger volumes in comparison to the originally configured electrode

Organizational Development: Values, Process, and Technology.

Science.gov (United States)

Margulies, Newton; Raia, Anthony P.

The current state-of-the-art of organizational development is the focus of this book. The five parts into which the book is divided are as follows: Part One--Introduction (Organizational Development in Perspective--the nature, values, process, and technology of organizational development); Part Two--The Components of Organizational Developments…

Assessment of a Newly Developed, Active Pneumatic-Driven, Sensorimotor Test and Training Device

Directory of Open Access Journals (Sweden)

Wolfram Haslinger

2014-12-01

Full Text Available The sensorimotor system (SMS plays an important role in sports and in every day movement. Several tools for assessment and training have been designed. Many of them are directed to specific populations, and have major shortcomings due to the training effect or safety. The aim of the present study was to design and assess a dynamic sensorimotor test and training device that can be adjusted for all levels of performance. The novel pneumatic-driven mechatronic device can guide the trainee, allow independent movements or disrupt the individual with unpredicted perturbations while standing on a platform. The test-reliability was evaluated using intraclass correlation coefficient (ICC. Subjects were required to balance their center of pressure (COP in a target circle (TITC. The time in TITC and the COP error (COPe were recorded for analysis. The results of 22 males and 14 females (23.7 ± 2.6 years showed good to excellent test–retest reliability. The newly designed Active Balance System (ABS was then compared with the Biodex Balance System SD® (BBS. The results of 15 females, 14 males (23.4 ± 1.6 years showed modest correlation in static and acceptable correlation in dynamic conditions, suggesting that ABS could be a reliable and comparable tool for dynamic balance assessments.

Development of a Novel Contamination Resistant Ion Chamber for Process Tritium Measurement and Use in the JET First Trace Tritium Experiment

International Nuclear Information System (INIS)

Worth, L.B.C.; Pearce, R.J.H.; Bruce, J.; Banks, J.; Scales, S.

2005-01-01

The accuracy of process measurements of tritium with conventional ion chambers is often affected by surface tritium contamination. The measurement of tritium in the exhaust of the JET torus is particularly difficult due to surface contamination with highly tritiated hydrocarbons. JET's first unsuccessful attempt to overcome the contamination problem was to use an ion chamber, with a heating element as the chamber wall so that it could be periodically decontaminated by baking. The newly developed ion chamber works on the principle of minimising the surface area within the boundary of the anode and cathode.This paper details the design of the ion chamber, which utilises a grid of 50-micron tungsten wire to define the ion chamber wall and the collector electrode. The effective surface area which, by contamination, is able to effect the measurement of tritium within the process gas has been reduced by a factor of ∼200 over a conventional ion chamber. It is concluded that the new process ion chamber enables sensitive accurate tritium measurements free from contamination issues. It will be a powerful new tool for future tritium experiments both to improve tritium tracking and to help in the understanding of tritium retention issues

Development of new metal matrix composite electrodes for electrical discharge machining through powder metallurgy process

Directory of Open Access Journals (Sweden)

C. Mathalai Sundaram

2014-12-01

Full Text Available Electrical discharge machining (EDM is one of the widely used nontraditional machining methods to produce die cavities by the erosive effect of electrical discharges. This method is popular due to the fact that a relatively soft electrically conductive tool electrode can machine hard work piece. Copper electrode is normally used for machining process. Electrode wear rate is the major drawback for EDM researchers. This research focus on fabrication of metal matrix composite (MMC electrode by mixing copper powder with titanium carbide (TiC and Tungsten carbide (WC powder through powder metallurgy process, Copper powder is the major amount of mixing proportion with TiC and WC. However, this paper focus on the early stage of the project where powder metallurgy route was used to determine suitable mixing time, compaction pressure and sintering and compacting process in producing EDM electrode. The newly prepared composite electrodes in different composition are tested in EDM for OHNS steel.

Validation of mentorship model for newly qualified professional ...

African Journals Online (AJOL)

Newly qualified professional nurses (NQPNs) allocated to community health care services require the use of validated model to practice independently. Validation was done to adapt and assess if the model is understood and could be implemented by NQPNs and mentors employed in community health care services.

Development of modified FT (MFT) process

Energy Technology Data Exchange (ETDEWEB)

Jinglai Zhou; Zhixin Zhang; Wenjie Shen [Institute of Coal Chemistry, Taiyuan (China)] [and others

1995-12-31

Two-Stage Modified FT (MFT) process has been developed for producing high-octane gasoline from coal-based syngas. The main R&D are focused on the development of catalysts and technologies process. Duration tests were finished in the single-tube reactor, pilot plant (100T/Y), and industrial demonstration plant (2000T/Y). A series of satisfactory results has been obtained in terms of operating reliability of equipments, performance of catalysts, purification of coal - based syngas, optimum operating conditions, properties of gasoline and economics etc. Further scaling - up commercial plant is being considered.

Development of Flexible Software Process Lines with Variability Operations

DEFF Research Database (Denmark)

Schramm, Joachim; Dohrmann, Patrick; Kuhrmann, Marco

2015-01-01

families of processes and, as part of this, variability operations provide means to modify and reuse pre-defined process assets. Objective: Our goal is to evaluate the feasibility of variability operations to support the development of flexible software process lines. Method: We conducted a longitudinal......Context: Software processes evolve over time and several approaches were proposed to support the required flexibility. Yet, little is known whether these approaches sufficiently support the development of large software processes. A software process line helps to systematically develop and manage...

Understanding and Managing Process Interaction in IS Development Projects

DEFF Research Database (Denmark)

Bygstad, Bendik; Nielsen, Peter Axel

2005-01-01

Increasingly, information systems must be developed and implemented as a part of business change. This is a challenge for the IS project manager, since business change and information systems development usually are performed as separate processes. Thus, there is a need to understand and manage......-technical innovation in a situation where the organisational change process and the IS development process are parallel but incongruent. We also argue that iterative software engineering frameworks are well structured to support process interaction. Finally, we advocate that the IS project manager needs to manage...... the relationship between these two kinds of processes. To understand the interaction between information systems development and planned organisational change we introduce the concept of process interaction. We draw on a longitudinal case study of an IS development project that used an iterative and incremental...

Process-Based Quality (PBQ) Tools Development

Energy Technology Data Exchange (ETDEWEB)

Cummins, J.L.

2001-12-03

The objective of this effort is to benchmark the development of process-based quality tools for application in CAD (computer-aided design) model-based applications. The processes of interest are design, manufacturing, and quality process applications. A study was commissioned addressing the impact, current technologies, and known problem areas in application of 3D MCAD (3-dimensional mechanical computer-aided design) models and model integrity on downstream manufacturing and quality processes. The downstream manufacturing and product quality processes are profoundly influenced and dependent on model quality and modeling process integrity. The goal is to illustrate and expedite the modeling and downstream model-based technologies for available or conceptual methods and tools to achieve maximum economic advantage and advance process-based quality concepts.

Newly divided eosinophils limit ozone-induced airway hyperreactivity in nonsensitized guinea pigs.

Science.gov (United States)

Wicher, Sarah A; Jacoby, David B; Fryer, Allison D

2017-06-01

Ozone causes vagally mediated airway hyperreactivity and recruits inflammatory cells, including eosinophils, to lungs, where they mediate ozone-induced hyperreactivity 1 day after exposure but are paradoxically protective 3 days later. We aimed to test the role of newly divided eosinophils in ozone-induced airway hyperreactivity in sensitized and nonsensitized guinea pigs. Nonsensitized and sensitized guinea pigs were treated with 5-bromo-2-deoxyuridine (BrdU) to label newly divided cells and were exposed to air or ozone for 4 h. Later (1 or 3 days later), vagally induced bronchoconstriction was measured, and inflammatory cells were harvested from bone marrow, blood, and bronchoalveolar lavage. Ozone induced eosinophil hematopoiesis. One day after ozone, mature eosinophils dominate the inflammatory response and potentiate vagally induced bronchoconstriction. However, by 3 days, newly divided eosinophils have reached the lungs, where they inhibit ozone-induced airway hyperreactivity because depleting them with antibody to IL-5 or a TNF-α antagonist worsened vagally induced bronchoconstriction. In sensitized guinea pigs, both ozone-induced eosinophil hematopoiesis and subsequent recruitment of newly divided eosinophils to lungs 3 days later failed to occur. Thus mature eosinophils dominated the ozone-induced inflammatory response in sensitized guinea pigs. Depleting these mature eosinophils prevented ozone-induced airway hyperreactivity in sensitized animals. Ozone induces eosinophil hematopoiesis and recruitment to lungs, where 3 days later, newly divided eosinophils attenuate vagally mediated hyperreactivity. Ozone-induced hematopoiesis of beneficial eosinophils is blocked by a TNF-α antagonist or by prior sensitization. In these animals, mature eosinophils are associated with hyperreactivity. Thus interventions targeting eosinophils, although beneficial in atopic individuals, may delay resolution of airway hyperreactivity in nonatopic individuals. Copyright �

Examination of in vivo gelatinolytic activity in rheumatoid arthritis synovial tissue using newly developed in situ zymography and image analyzer.

Science.gov (United States)

Yoshida, W; Uzuki, M; Nishida, J; Shimamura, T; Sawai, T

2009-01-01

The aim of this study was to examine in vivo gelatinolytic activity of rheumatoid arthritis (RA) synovium using a newly developed in situ zymography (ISZ) method and pathological image analyzer, and to evaluate the relationship between this activity and several features on RA. A total of 8 samples of synovium were obtained from RA patients during surgery, and 8 samples from osteoarthritis (OA) patients were examined as controls. Furthermore, total 14 samples of syovium were obtained for comparison among radiographical classifications as Larsen grade (4 cases of grade III, 5 cases of grade IV and 5 cases of grade V). These specimens were frozen with OCT compound immediately after surgery. Frozen sections were applied to a newly developed gelatin-coated FIZ film (Fuji Film Co.Tokyo.Japan) designed for use ISZ, and incubated at 37 degrees C for 6 hours. Using an image analyzer (image processor for analytical pathology; IPAP), two variables were measured as indicators of in vivo gelatynolytic activity: optical density of gelatinolyzed area (ODG), and ratio of gelatinolyzed area (RGA). Also, we investigated the relationship between these indicators and the following variables: radiographic changes (Larsen grades), clinical data (C-reactive protein concentration), histological score of synovial tissue (modified Rooney's score), and expression of matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 (assessed by immunohistochemistry). RA synovium had significantly higher RGA and lower ODG than OA, indicating higher gelatinolytic activity in RA. Synovium from cases with Larsen grade IV or V had significantly lower ODG than cases with grade III, but there was no significant difference in RGA between grades. There was no significant correlation between gelatinolytic activity (ODG or RGA) and either CRP or modified Rooney's Histological Score. The results of ISZ indicate that the gelatinolyzed areas were mainly localized in the

Software process improvement: controlling developers, managers or users?

DEFF Research Database (Denmark)

Nørbjerg, Jacob

1999-01-01

The paper discusses how the latest trend in the management of software development: software process improvement (SPI) may affect user-developer relations. At the outset, SPI concerns the "internal workings" of software organisations, but it may also be interpreted as one way to give the developer...... organisation more control over the development process and the relations with the user organization....

Development of Water Detritiation Process Using the Hydrophobic Platinum Catalyst

International Nuclear Information System (INIS)

Ahn, D.H.; Paek, S.; Choi, H.J.; Kim, K.R.; Chung, H.; Yim, S.P.; Lee, M.S.

2006-01-01

Radioactive emissions and occupational doses by tritium are mainly caused by tritiated water escaping from equipment in the nuclear industry. Improving the leak-tightness of equipment is effective in reducing emissions and internal dose but is not a long-term solution. Water detritiation was consider to be the most effective tritium control option since tritium is removed right from the source. The WTRF (Wolsong Tritium Removal Facility) is under construction now with the completion date of June, 2006 in Korea. It is designed to remove tritium from tritiated heavy water in each of the existing four Candu units at Wolsong site. We developed a hydrophobic platinum catalyst (Pt/SDBC catalyst) that would be used at the LPCE (Liquid Phase Catalytic Exchange) column in the WTRF. The catalytic rate constants of the newly developed catalyst for the deuterium exchange reaction between water vapor and hydrogen gas were measured in a recycle reactor. The catalytic rate constants of the Pt/SDBC catalyst decreased with reaction time and were much greater than that required, 2.0 x 10 -4 mol (D 2 )/s/g(pellet) in the design of the WTRF. Tritium removal efficiency of the WTRF, which is important for a safe and reliable operation of the facility, depends on the design and operating variables. A theoretical model based on the design and operating variables of the LPCE process was set up, and the equations between the parameters were derived. Numerical calculation result from a computer program shows steep increase of the detritiation factor of the LPCE process with respect to temperature increase and mild increase with respect to pressure decrease. The other parametric study shows that the calculated detritiation factors increase as the catalyst efficiency, number of theoretical stages of hydrophilic packing, the detritiation factor of cryogenic distillation system and the total number of sections increase. We also proceeded with the experiments for the hydrogen isotopic exchange

Neuropsychological and psychological interventions for people with newly diagnosed epilepsy.

Science.gov (United States)

Jackson, Cerian F; Makin, Selina M; Baker, Gus A

2015-07-22

Many people with epilepsy report experiencing psychological difficulties such as anxiety, depression and neuropsychological deficits including memory problems. Research has shown that these difficulties are often present not only for people with chronic epilepsy but also for people with newly diagnosed epilepsy. Despite this, there are very few published interventions that detail means to help people with newly diagnosed epilepsy manage these problems. To identify and assess possible psychological and neuropsychological interventions for adults with newly diagnosed epilepsy. We searched the following databases on 30 June 2015: the Cochrane Epilepsy Group Specialized Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (Ovid), SCOPUS, PsycINFO, CINAHL, ClinicalTrials.gov and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP). This review includes all randomised controlled trials, quasi-randomised controlled trials, prospective cohort controlled studies, and prospective before and after studies which include psychological or neuropsychological interventions for people with newly diagnosed epilepsy. We excluded studies that included people with epilepsy and any other psychological disorder or neurological condition. We excluded studies carried out which recruited only children. We used the standard methodological procedure expected by The Cochrane Collaboration. Two authors independently completed data extraction and risk of bias analysis. The results of this were cross-checked and third author resolved any discrepancies. In the event of missing data, we contacted the study authors. Meta-analysis was not completed due to differences in the intervention and outcomes reported in the two studies. We included two randomised controlled trials assessing psychological interventions for people with newly diagnosed epilepsy. One study assessed a cognitive behavioural intervention (CBI) in an adolescent

Vibro-acoustic performance of newly designed tram track structures

Science.gov (United States)

Haladin, Ivo; Lakušić, Stjepan; Ahac, Maja

2017-09-01

Rail vehicles in interaction with a railway structure induce vibrations that are propagating to surrounding structures and cause noise disturbance in the surrounding areas. Since tram tracks in urban areas often share the running surface with road vehicles one of top priorities is to achieve low maintenance and long lasting structure. Research conducted in scope of this paper gives an overview of newly designed tram track structures designated for use on Zagreb tram network and their performance in terms of noise and vibration mitigation. Research has been conducted on a 150 m long test section consisted of three tram track types: standard tram track structure commonly used on tram lines in Zagreb, optimized tram structure for better noise and vibration mitigation and a slab track with double sleepers embedded in a concrete slab, which presents an entirely new approach of tram track construction in Zagreb. Track has been instrumented with acceleration sensors, strain gauges and revision shafts for inspection. Relative deformations give an insight into track structure dynamic load distribution through the exploitation period. Further the paper describes vibro-acoustic measurements conducted at the test site. To evaluate the track performance from the vibro-acoustical standpoint, detailed analysis of track decay rate has been analysed. Opposed to measurement technique using impact hammer for track decay rate measurements, newly developed measuring technique using vehicle pass by vibrations as a source of excitation has been proposed and analysed. Paper gives overview of the method, it’s benefits compared to standard method of track decay rate measurements and method evaluation based on noise measurements of the vehicle pass by.

Microstructure and mechanical properties of newly developed aluminum–lithium alloy 2A97 welded by fiber laser

Energy Technology Data Exchange (ETDEWEB)

Fu, Banglong [Key Laboratory for Liquid–Solid Structural Evolution and Processing of Materials Ministry of Education, Shandong University, Jinan 250061 (China); Qin, Guoliang, E-mail: glqin@sdu.edu.cn [Key Laboratory for Liquid–Solid Structural Evolution and Processing of Materials Ministry of Education, Shandong University, Jinan 250061 (China); Meng, Xiangmeng; Ji, Yang; Zou, Yong [Key Laboratory for Liquid–Solid Structural Evolution and Processing of Materials Ministry of Education, Shandong University, Jinan 250061 (China); Lei, Zhen [Harbin Welding Institute, Harbin 150028 (China)

2014-11-03

The newly developed aluminum–lithium alloy 2A97 was for the first time joined by laser beam welding in order to meet the ever-increased long-term requirements of aerospace, aviation and armament industries. The weld appearance, microstructure, solute segregation, precipitate behavior, and their relationships with mechanical properties of welded joints were investigated. Sound joints with no crack and a few small porosities are obtained under appropriate heat inputs. As a result of heterogeneous nucleation involving the effect of Zr and Li, a non-dendritic equiaxed zone forms between partially melted zone and fusion zone. The crystal morphologies in fusion zone vary from columnar dendrite to equiaxed dendrite, with the increase of constitutional supercooling. Solute segregation leads to the variations of Cu content in grain interior and boundary, as well as the weak ability of re-precipitation of fusion zone. Most precipitates in the base metal dissolve during welding, and fusion zone contains a decreased quantity of δ′, β′, θ′, and T{sub 1}. The ultimate tensile strength of laser welded joints is 83.4% of that of the base metal, and can meet the application requirements from related industries, but the ductility still needs to be improved. Welding defects and loss of solid solution/precipitation hardened structure lead to the degradation of mechanical properties. Tensile fracture occurs in weld with the brittle intergranular dominated mode and premature failure occurs and extends in the equiaxed zone.

Patients newly diagnosed with clinical type 2 diabetes during oral glucocorticoid treatment and observed for 14 years: all-cause mortality and clinical developments

DEFF Research Database (Denmark)

Olivarius, Niels de Fine; Siersma, Volkert Dirk; Dyring-Andersen, B.

2011-01-01

and sex and to 1.39 (0.92-2.11, p = 0.12, n = 1086) when risk factors, complications and cancer were added to the model. Apart from differences in age and overweight, patients in this relatively small sample of those diagnosed with clinical type 2 diabetes during GC treatment were comparable at diagnosis...... treatment. A population-based sample of 1369 people newly diagnosed with clinical type 2 diabetes underwent a clinical examination at diagnosis, and surviving patients were followed up 6 and 14 years later. Patients receiving oral GC treatment at diagnosis were compared with the other patients. Of 1369......Chronic exposure to glucocorticoids (GCs) has many side effects including glucose intolerance and diabetes and may accelerate the occurrence of cardiovascular disease and increase mortality. We studied the 14-year clinical development of diabetes in patients diagnosed with diabetes during GC...

Development of the Fischer-Tropsch Process: From the Reaction Concept to the Process Book

Directory of Open Access Journals (Sweden)

Boyer C.

2016-05-01

Full Text Available The process development by IFP Energies nouvelles (IFPEN/ENI/Axens of a Fischer-Tropsch process is described. This development is based on upstream process studies to choose the process scheme, reactor technology and operating conditions, and downstream to summarize all development work in a process guide. A large amount of work was devoted to the catalyst performances on one hand and the scale-up of the slurry bubble reactor with dedicated complementary tools on the other hand. Finally, an original approach was implemented to validate both the process and catalyst on an industrial scale by combining a 20 bpd unit in ENI’s Sannazzaro refinery, with cold mock-ups equivalent to 20 and 1 000 bpd at IFPEN and a special “Large Validation Tool” (LVT which reproduces the combined effect of chemical reaction condition stress and mechanical stress equivalent to a 15 000 bpd industrial unit. Dedicated analytical techniques and a dedicated model were developed to simulate the whole process (reactor and separation train, integrating a high level of complexity and phenomena coupling to scale-up the process in a robust reliable base on an industrial scale.

[Epidemiological characteristics of newly reported HIV infections in Chinese and Burmese residents, during 2012-2016 in Dehong Dai and Jingpo Autonomous Prefecture, Yunnan province].

Science.gov (United States)

Wang, J B; Chen, X C; Duan, X; Yang, J; Wang, Y K; Yang, T; Ye, R H; Yang, Y C; Yao, S T; Jiang, Y; Duan, S; He, N

2017-10-10

Objective: To understand the epidemiological characteristics of newly reported HIV infections in Chinese and Burmese residents during 2012-2016 in Dehong Dai and Jingpo Autonomous Prefecture of Yunnan province (Dehong) and to provide evidence for the development of related programs on prevention and control. Methods: All the HIV infections who were newly reported during 2012-2016 in Dehong, were recruited as the study subjects, with epidemiological characteristics of the cases analyzed by using the software SPSS 22.0. Results: A total of 5 692 HIV infections were newly reported between 2012 and 2016 (including 5 592 in this study), in which the Chinese patients accounted for 43.3 % (2 419) and the rest 56.7 % (3 173) were Burmese. Differences in age, gender and other social characteristics of these newly reported HIV infections were statistically significant between the Chinese and the Burmese (all p -values Chinese patients but through injecting drug use among the Burmese patients. Conclusions: Epidemiological characteristics of the newly reported HIV infections were different between the Chinese and the Burmese, between 2012 and 2016 in Dehong. Targeted prevention and control programs should be taken.

NO/sub x/ removal facility: MON process

Energy Technology Data Exchange (ETDEWEB)

Fukuda, Y

1974-05-01

A newly developed process for nitrogen oxides removal is described. The MON process, named for Mitsubishi Kizoku, Okabe of Tohoku Univ., and Nippon Kagaku, uses potassium permanganate as an oxidizing agent. Potassium permanganate in alkaline solution converts nitric oxide into nitrate and nitrogen dioxide into nitric acid. The resulting MnO/sub 2/ is easily filtered and recovered as material for the manufacturing of KMnO/sub 4/. Contrary to the conventional methods, the NO/sub x/ conversion rate increases with increasing temperature. Test results at a pilot plant showed that NO/sub x/ was reduced from 570 ppM (nitric oxide 520 ppM) to 27 ppM (mostly NO) at 97 to 98 percent conversion. Another advantage of the process is that other acidic gases such as sulfur dioxide are also removed.

THE ADMISSION OF NEWLY CREATED STATES TO THE MEMBERSHIP OF THE UNITED NATIONS: THE CASE OF REPUBLIC OF MACEDONIA

Directory of Open Access Journals (Sweden)

Milorad Petreski

2017-01-01

Full Text Available The international law which regulates the formation, functioning and legal capacity of international organizations, and also the international law in the United Nations system, are always relevant and subject to progressive development, because the international relations are in constant dynamics. Each newly created state has one major foreign policy goal during its first years of formation or after obtaining independence – admission to the membership of the United Nations. That is because the decision of admission to the membership of the UN guarantees the country’s statehood which can no longer be questioned. The country becomes part of a global community of nations – the international community. Therefore, the present paper is a qualitative research regarding the admission of new states to the international community, and the decision-making process concerning the admission of new Member States to the UN.

Assessing the comparative effectiveness of newly marketed medications: methodological challenges and implications for drug development.

Science.gov (United States)

Schneeweiss, S; Gagne, J J; Glynn, R J; Ruhl, M; Rassen, J A

2011-12-01

Comparative-effectiveness research (CER) aims to produce actionable evidence regarding the effectiveness and safety of medical products and interventions as they are used outside of controlled research settings. Although CER evidence regarding medications is particularly needed shortly after market approval, key methodological challenges include (i) potential bias due to channeling of patients to the newly marketed medication because of various patient-, physician-, and system-related factors; (ii) rapid changes in the characteristics of the user population during the early phase of marketing; and (iii) lack of timely data and the often small number of users in the first few months of marketing. We propose a mix of approaches to generate comparative-effectiveness data in the early marketing period, including sequential cohort monitoring with secondary health-care data and propensity score (PS) balancing, as well as extended follow-up of phase III and phase IV trials, indirect comparisons of placebo-controlled trials, and modeling and simulation of virtual trials.

Mentoring program for students newly enrolled in an Engineering Degree

Directory of Open Access Journals (Sweden)

Juan Pedro Peña-Martín

2016-10-01

Full Text Available This work presents a mentoring program for first year engineering students in the Telecommunications Engineering College (ETSIT at the University of Malaga (UMA. Actors involved in the program are professors from staff, veterans mentoring students and, of course, freshmen. All of them has been organized trough the Moodle based Virtual Learning Environment Platform of the UMA. The program has gone through several phases over three years. This paper shows the main objectives of this mentoring program, the initial design to get them where professors played mentor role, and successive changes made to try to improve the results, including the assumption of the mentor role by senior students (peer mentoring. The tools used for program evaluation are shown too. Despite the low participation, it has been a framework for the development of various educational and socializing activities (for mentors and mentees focused on developing generic competences. Furthermore, it has been a research tool to get a better understanding of problems affecting students newly enrolled.

Biomechanical Skin Property Evaluation for Wounds Treated With Synthetic and Biosynthetic Wound Dressings and a Newly Developed Collagen Matrix During Healing of Superficial Skin Defects in a Rat Models.

Science.gov (United States)

Held, Manuel; Engelke, Anne-Sophie; Tolzmann, Dascha Sophie; Rahmanian-Schwarz, Afshin; Schaller, Hans-Eberhard; Rothenberger, Jens

2016-09-01

There is a high prevalence of superficial wounds such as partial-thickness burns. Treatment of these wounds frequently includes temporary application of wound dressings. The aim of this study was to compare a newly developed collagen matrix with commonly used temporary skin dressings for treatment of partial-thickness skin defects. Through a skin dermatome, 42 standardized superficial skin defects were generated on the back of 28 adult male Lewis rats. The wounds were treated with a synthetic wound dressing (Suprathel, Polymedics Innovations Inc, Woodstock, GA) (n = 14), a biosynthetic skin dressing (Biobrane, Smith & Nephew, Hull, UK) (n = 14), or a newly developed bovine collagen matrix, Collagen Cell Carrier (Viscofan BioEngineering, Weinheim, Germany) (n = 14). Biomechanical properties of the skin were determined and compared every 10 days over a 3-month period of using the Cutometer MPA 580 (Courage + Khazaka Electronic GmbH, Cologne, Germany). As opposed to healthy skin, statistically significant differences were detected between days 10 and 30, and between days 60 and 80, for calculated elasticity (Ue), firmness of skin (R0), and overall elasticity (R8). After 3 months, no statistically significant differences in skin elasticity were detected between the different wound dressings. The presented results give an opportunity to compare the wound dressings used for treatment with respect to skin elasticity and reveal the potential of the bovine collagen matrix in the treatment of superficial skin defects; therefore the results facilitate further evaluation of collagen matrix in surgical applications and regenerative medicine.

An efficient process for lactic acid production from wheat straw by a newly isolated Bacillus coagulans strain IPE22

DEFF Research Database (Denmark)

Zhang, Yuming; Chen, Xiangrong; Luo, Jianquan

2014-01-01

features, an efficient process was developed to produce LA from wheat straw. The process consisted of biomass pretreatment by dilute sulfuric acid and subsequent SSCF (simultaneous saccharification and co-fermentation), while the operations of solid–liquid separation and detoxification were avoided. Using...... this process, 46.12 g LA could be produced from 100 g dry wheat straw with a supplement of 10 g/L corn steep liquid powder at the cellulase loading of 20 FPU (filter paper activity units)/g cellulose. The process by B. coagulans IPE22 provides an economical route to produce LA from lignocellulose...

Modeling surface topography of state-of-the-art x-ray mirrors as a result of stochastic polishing process: recent developments

Science.gov (United States)

Yashchuk, Valeriy V.; Centers, Gary; Tyurin, Yuri N.; Tyurina, Anastasia

2016-09-01

Recently, an original method for the statistical modeling of surface topography of state-of-the-art mirrors for usage in xray optical systems at light source facilities and for astronomical telescopes [Opt. Eng. 51(4), 046501, 2012; ibid. 53(8), 084102 (2014); and ibid. 55(7), 074106 (2016)] has been developed. In modeling, the mirror surface topography is considered to be a result of a stationary uniform stochastic polishing process and the best fit time-invariant linear filter (TILF) that optimally parameterizes, with limited number of parameters, the polishing process is determined. The TILF model allows the surface slope profile of an optic with a newly desired specification to be reliably forecast before fabrication. With the forecast data, representative numerical evaluations of expected performance of the prospective mirrors in optical systems under development become possible [Opt. Eng., 54(2), 025108 (2015)]. Here, we suggest and demonstrate an analytical approach for accounting the imperfections of the used metrology instruments, which are described by the instrumental point spread function, in the TILF modeling. The efficacy of the approach is demonstrated with numerical simulations for correction of measurements performed with an autocollimator based surface slope profiler. Besides solving this major metrological problem, the results of the present work open an avenue for developing analytical and computational tools for stitching data in the statistical domain, obtained using multiple metrology instruments measuring significantly different bandwidths of spatial wavelengths.

GABA regulates synaptic integration of newly generated neurons in the adult brain

Science.gov (United States)

Ge, Shaoyu; Goh, Eyleen L. K.; Sailor, Kurt A.; Kitabatake, Yasuji; Ming, Guo-Li; Song, Hongjun

2006-02-01

Adult neurogenesis, the birth and integration of new neurons from adult neural stem cells, is a striking form of structural plasticity and highlights the regenerative capacity of the adult mammalian brain. Accumulating evidence suggests that neuronal activity regulates adult neurogenesis and that new neurons contribute to specific brain functions. The mechanism that regulates the integration of newly generated neurons into the pre-existing functional circuitry in the adult brain is unknown. Here we show that newborn granule cells in the dentate gyrus of the adult hippocampus are tonically activated by ambient GABA (γ-aminobutyric acid) before being sequentially innervated by GABA- and glutamate-mediated synaptic inputs. GABA, the major inhibitory neurotransmitter in the adult brain, initially exerts an excitatory action on newborn neurons owing to their high cytoplasmic chloride ion content. Conversion of GABA-induced depolarization (excitation) into hyperpolarization (inhibition) in newborn neurons leads to marked defects in their synapse formation and dendritic development in vivo. Our study identifies an essential role for GABA in the synaptic integration of newly generated neurons in the adult brain, and suggests an unexpected mechanism for activity-dependent regulation of adult neurogenesis, in which newborn neurons may sense neuronal network activity through tonic and phasic GABA activation.

Big earth-observation data analytics for modelling pan-tropical land-use change trajectories for newly deforested areas

Science.gov (United States)

Coca Castro, Alejandro; Reymondin, Louis; Rebetez, Julien; Fabio Satizabal Mejia, Hector; Perez-Uribe, Andres; Mulligan, Mark; Smith, Thomas; Hyman, Glenn

2017-04-01

Global land use monitoring is important to the the Sustainable Development Goals (SDGs). The latest advances in storage and manipulation of big earth-observation data have been key to developing multiple operational forest monitoring initiatives such as FORMA, Terra-i and Global Forest Change. Although the data provided by these systems are useful for identifying and estimating newly deforested areas (from 2000), they do not provide details about the land use to which these deforested areas are transitioned. This information is critical to understand the biodiversity and ecosystem services impact of deforestation and the resulting impacts on human wellbeing, locally and downstream. With the aim of contributing to current forest monitoring initiatives, this research presents a set of experimental case studies in Latin America which integrate existing land-change information derived from remote sensing image and aerial photography/ground datasets, high-temporal resolution MODIS data, advanced machine learning (i.e deep learning) and big data technologies (i.e. Hadoop and Spark) to assess land-use change trajectories in newly deforested areas in near real time.

Protogalaxy interactions in newly formed clusters: Galaxy luminosities, colors, and intergalactic gas

International Nuclear Information System (INIS)

Silk, J.

1978-01-01

The role of protogalaxy interactions in galactic evolution is studied during the formation of galaxy clusters. In the early stages of the collapse, coalescent encounters of protogalaxies lead to the development of a galactic luminosity function. Once galaxies acquire appreciable random motions, mutual collisions between galaxies in rich clusters will trigger the collapse of interstellar clouds to form stars. This provides both a source for enriched intracluster gas and an interpretation of the correlation between luminosity and color for cluster elliptical galaxies. Other observational consequences that are considered include optical, X-ray, and diffuse nonthermal radio emission from newly formed clusters of galaxies

Best management practices for newly weaned calves for improved health and well-being.

Science.gov (United States)

Wilson, B K; Richards, C J; Step, D L; Krehbiel, C R

2017-05-01

Morbidity and mortality in newly weaned calves resulting from bovine respiratory disease (BRD) continue to be the most significant problems facing the beef industry. Morbidity attributed to BRD accounts for approximately 75% of total feedlot morbidity. Several experiments have documented the economic impacts of BRD. Direct costs attributable to BRD include death loss, treatment and labor costs, and prevention costs, while indirect costs associated with BRD include decreased growth performance and feed efficiency, increased days on feed, and decreased carcass merit and market value. In recent years, cattle treated for BRD have returned $50 to $250 less per head at harvest than cattle never treated for BRD. Best management practices for newly weaned calves vary depending on a multitude of factors including: season of year calves are purchased, calf genetics, length of time in the marketing and transport channels, previous management and vaccination programs, and other factors. In general, calves purchased directly from a ranch have fewer health problems than calves purchased through auction markets. The longer a calf is in the marketing chain, the more likely health problems will be encountered. Calves that have spent several days in the marketing chain may develop clinical BRD before or very soon after arrival, whereas cattle with less time in the marketing chain may get sick later (2 to 4 wk), due to the length of time it takes for BRD to develop. On or before arrival, calves should be given a risk score (high, medium, or low) that relates to the quantity and magnitude of stress they have encountered and the probability they will develop BRD. High-risk calves typically will have been recently weaned, received no vaccinations, not been castrated or dehorned, been commingled, and moved through an auction market. Low-risk calves will often originate from a single source and will have gone through a preconditioning program that includes vaccination, castration

DISABILITIES OF HANDS, FEET AND EYES IN NEWLY-DIAGNOSED LEPROSY PATIENTS IN EASTERN NEPAL

NARCIS (Netherlands)

SCHIPPER, A; LUBBERS, WJ; HOGEWEG, M; DESOLDENHOFF, R

The objective of the study was to determine the magnitude of hand/feet/eye disabilities in newly diagnosed leprosy patients by examining all newly diagnosed leprosy patients who presented at the Eastern Leprosy Control Project (supported by The Netherlands Leprosy Relief Association), made up of a

Antipsychotic medications and dental caries in newly diagnosed schizophrenia: A nationwide cohort study.

Science.gov (United States)

Hu, Kai-Fang; Chou, Yu-Hsiang; Wen, Yen-Hsia; Hsieh, Kun-Pin; Tsai, Jui-Hsiu; Yang, Pinchen; Yang, Yi-Hsin; Lin, Chun-Hung Richard

2016-11-30

We investigated the association between antipsychotic medications and the risk of dental caries in patients with schizophrenia. We enroled a nationwide cohort of patients with newly diagnosed schizophrenia within 1 year of dental caries development. Exposure to antipsychotics and other medications was categorised according to their type and duration, and the association between exposure and dental caries was assessed through logistic regressions. Of the 3610 patients with newly diagnosed schizophrenia, 2149 (59.5%) exhibited an incidence of treated dental caries. Logistic regression analysis identified a younger age, female sex, high income, a 2-year history of dental caries, and exposure to first-generation antipsychotics, and antihypertensives as independent risk factors for treated dental caries in patients with schizophrenia. Hyposalivation, the adverse effect of first-generation antipsychotics and antihypertensives, was associated with an increased risk of treated dental caries. However, hypersalivation from first-generation antipsychotics for dental caries was associated with a protective factor. These findings suggest that clinicians should pay attention to the aforementioned risk factors for dental caries in patients with schizophrenia, particularly while prescribing first-generation antipsychotics and antihypertensives to such patients. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

A Software Development Simulation Model of a Spiral Process

Science.gov (United States)

Mizell, Carolyn; Malone, Linda

2007-01-01

There is a need for simulation models of software development processes other than the waterfall because processes such as spiral development are becoming more and more popular. The use of a spiral process can make the inherently difficult job of cost and schedule estimation even more challenging due to its evolutionary nature, but this allows for a more flexible process that can better meet customers' needs. This paper will present a discrete event simulation model of spiral development that can be used to analyze cost and schedule effects of using such a process in comparison to a waterfall process.

Delivering the diabetes education and self management for ongoing and newly diagnosed (DESMOND) programme for people with newly diagnosed type 2 diabetes

DEFF Research Database (Denmark)

Gillett, M.; Dallosso, H. M.; Dixon, S.

2010-01-01

intervention is £82 (-£831 to £1010) and the mean incremental cost per QALY gained is £2092. A probabilistic sensitivity analysis indicated that the likelihood that the DESMOND programme is cost effective at a threshold of £20 000 per QALY is 66% using trial based intervention costs and 70% using "real world......Objectives: To assess the long term clinical and cost effectiveness of the diabetes education and self management for ongoing and newly diagnosed (DESMOND) intervention compared with usual care in people with newly diagnosed type 2 diabetes. Design: We undertook a cost-utility analysis that used...... data from a 12 month, multicentre, cluster randomised controlled trial and, using the Sheffield type 2 diabetes model, modelled long term outcomes in terms of use of therapies, incidence of complications, mortality, and associated effect on costs and health related quality of life. A further cost...

Load-Bearing Capacity and Retention of Newly Developed Micro-Locking Implant Prosthetic System: An In Vitro Pilot Study

Directory of Open Access Journals (Sweden)

Jae-Won Choi

2018-04-01

Full Text Available The aim of this study was to introduce the newly developed micro-locking implant prosthetic system and to evaluate the resulting its characteristics. To evaluate load-bearing capacity, 25 implants were divided into five groups: external-hexagon connection (EH, internal-octagon connection (IO, internal-hexagon connection (IH, one-body implant (OB, micro-locking implant system (ML. The maximum compressive load was measured using a universal testing machine (UTM according to the ISO 14801. Retention was evaluated in two experiments: (1 a tensile test of the structure modifications of the components (attachment and implant and (2 a tensile test after cyclic loading (total 5,000,000 cycles, 100 N, 2 Hz. The load-bearing capacity of the ML group was not significantly different from the other groups (p > 0.05. The number of balls in the attachment and the presence of a hexagonal receptacle did not show a significant correlation with retention (p > 0.05, but the shape of the retentive groove in the implant post had a statistically significant effect on retention (p < 0.05. On the other hand, the retention loss was observed during the initial 1,000,000 cycles, but an overall constant retention was maintained afterward. Various preclinical studies on this novel micro-locking implant prosthetic system should continue so that it can be applied in clinical practice.

The Integrated Renovation Process

DEFF Research Database (Denmark)

Galiotto, Nicolas; Heiselberg, Per; Knudstrup, Mary-Ann

they get more time for the cost optimization and the qualitative analysis of the users’ needs and behaviours. In order to reach a fossil free energy building stock within an acceptable time frame, it is primordial that researchers, politicians and the building industry work hand in hand. Indeed, in order...... to overcome the financial barriers to energy renovation and bring a new type of building experts in the building renovation sector, cost optimization tools for building renovation have been and can be developed but new legislation and politico-economic supports are still much needed. We present in this report...... a new contribution from the research and industry sides and results reached with the newly developed methodology, but without a significant contribution from the politico-economic and legislation sides . The experiences met during application of the Integrated Renovation Process are described...

TU-FG-201-12: Designing a Risk-Based Quality Assurance Program for a Newly Implemented Y-90 Microspheres Procedure

Energy Technology Data Exchange (ETDEWEB)

Vile, D; Zhang, L; Cuttino, L; Kim, S; Palta, J [Virginia Commonwealth University, Richmond, VA (United States)

2016-06-15

Purpose: To create a quality assurance program based upon a risk-based assessment of a newly implemented SirSpheres Y-90 procedure. Methods: A process map was created for a newly implemented SirSpheres procedure at a community hospital. The process map documented each step of this collaborative procedure, as well as the roles and responsibilities of each member. From the process map, different potential failure modes were determined as well as any current controls in place. From this list, a full failure mode and effects analysis (FMEA) was performed by grading each failure mode’s likelihood of occurrence, likelihood of detection, and potential severity. These numbers were then multiplied to compute the risk priority number (RPN) for each potential failure mode. Failure modes were then ranked based on their RPN. Additional controls were then added, with failure modes corresponding to the highest RPNs taking priority. Results: A process map was created that succinctly outlined each step in the SirSpheres procedure in its current implementation. From this, 72 potential failure modes were identified and ranked according to their associated RPN. Quality assurance controls and safety barriers were then added for failure modes associated with the highest risk being addressed first. Conclusion: A quality assurance program was created from a risk-based assessment of the SirSpheres process. Process mapping and FMEA were effective in identifying potential high-risk failure modes for this new procedure, which were prioritized for new quality assurance controls. TG 100 recommends the fault tree analysis methodology to design a comprehensive and effective QC/QM program, yet we found that by simply introducing additional safety barriers to address high RPN failure modes makes the whole process simpler and safer.

TU-FG-201-12: Designing a Risk-Based Quality Assurance Program for a Newly Implemented Y-90 Microspheres Procedure

International Nuclear Information System (INIS)

Vile, D; Zhang, L; Cuttino, L; Kim, S; Palta, J

2016-01-01

Purpose: To create a quality assurance program based upon a risk-based assessment of a newly implemented SirSpheres Y-90 procedure. Methods: A process map was created for a newly implemented SirSpheres procedure at a community hospital. The process map documented each step of this collaborative procedure, as well as the roles and responsibilities of each member. From the process map, different potential failure modes were determined as well as any current controls in place. From this list, a full failure mode and effects analysis (FMEA) was performed by grading each failure mode’s likelihood of occurrence, likelihood of detection, and potential severity. These numbers were then multiplied to compute the risk priority number (RPN) for each potential failure mode. Failure modes were then ranked based on their RPN. Additional controls were then added, with failure modes corresponding to the highest RPNs taking priority. Results: A process map was created that succinctly outlined each step in the SirSpheres procedure in its current implementation. From this, 72 potential failure modes were identified and ranked according to their associated RPN. Quality assurance controls and safety barriers were then added for failure modes associated with the highest risk being addressed first. Conclusion: A quality assurance program was created from a risk-based assessment of the SirSpheres process. Process mapping and FMEA were effective in identifying potential high-risk failure modes for this new procedure, which were prioritized for new quality assurance controls. TG 100 recommends the fault tree analysis methodology to design a comprehensive and effective QC/QM program, yet we found that by simply introducing additional safety barriers to address high RPN failure modes makes the whole process simpler and safer.

The experience of learning to speak up: a narrative inquiry on newly graduated registered nurses.

Science.gov (United States)

Law, Bernice Yee-Shui; Chan, Engle Angela

2015-07-01

To explore the process of learning to speak up in practice among newly graduated registered nurses. Speaking up is an important aspect of communication to ensure patient safety within a healthcare team. However, nurses have reported being hesitant about speaking up or being unable to be heard, despite adopting various safety tools. A power differential could be a factor in their hesitation to speak up. While a large number of new graduates are employed in the lower rungs of the hospital hierarchy to resolve local and global nursing shortages, the process of their learning to speak up remains under-explored. The narrative concept of experience is addressed through the three-dimensional space of a narrative inquiry. Eighteen new graduates were recruited. Stories of experiences of speaking up emerged naturally during repeated unstructured interviews and ongoing email conversations with three participants. The complex process of learning to speak up is schematically represented. Three interrelated narrative threads were identified: (1) learning to speak up requires more than one-off training and safety tools, (2) mentoring speaking up in the midst of educative and miseducative experiences and (3) making public spaces safe for telling secret stories. Speaking up requires ongoing mentoring to see new possibilities for sustaining professional identities in the midst of miseducative experiences under the potential shaping of the Chinese culture and generational differences. Appreciative inquiry might be a new approach that can be used to promote positive cultural changes to encourage newly graduated registered nurses to learn to speak up to ensure patient safety. Cultivating a safe and open culture of communication and mentoring new graduates to speak up will benefit patient safety now and in the future by helping to retain committed patient advocates who could mentor future generations. © 2015 John Wiley & Sons Ltd.

The micro-processor controlled process radiation monitoring system for reactor safety systems

International Nuclear Information System (INIS)

Mizuno, K.; Noguchi, A.; Kumagami, S.; Gotoh, Y.; Kumahara, T.; Arita, S.

1986-01-01

Digital computers are soon expected to be applied to various real-time safety and safety-related systems in nuclear power plants. Hitachi is now engaged in the development of a micro-processor controlled process radiation monitoring system, which operates on digital processing methods employed with a log ratemeter. A newly defined methodology of design and test procedures is being applied as a means of software program verification for these safety systems. Recently implemented micro-processor technology will help to achieve an advanced man-machine interface and highly reliable performance. (author)

Application of an automatic yarn dismantler to track changes in cotton fiber properties during full scale processing of cotton into carded yarn

CSIR Research Space (South Africa)

Fassihi, A

2016-08-01

Full Text Available Changes in Upland cotton fiber properties from lint to carded yarn, during full scale processing, were tracked, using a newly developed automatic yarn dismantler for dismantling short staple ring-spun yarns. Opening and cleaning increased fiber neps...

Newly developed surface coil for endoluminal MRI, depiction of pig gastric wall layers and vascular architecture in ex vivo study.

Science.gov (United States)

Morita, Yoshinori; Kutsumi, Hiromu; Yoshinaka, Hayato; Matsuoka, Yuichiro; Kuroda, Kagayaki; Gotanda, Masakazu; Sekino, Naomi; Kumamoto, Etsuko; Yoshida, Masaru; Inokuchi, Hideto; Azuma, Takeshi

2009-01-01

The purpose of this study was to visualize the gastric wall layers and to depict the vascular architecture in vitro by using resected porcine stomachs studied with high-spatial resolution magnetic resonance (MR) imaging. Normal dissected porcine stomach samples (n = 4) were examined with a 3 Tesla MR system using a newly developed surface coil. MR images were obtained by the surface coil as receiver and a head coil as transmitter. High-spatial-resolution spin-echo MR images were obtained with a field of view of 8 x 8 cm, a matrix of 256 x 128 and slice thicknesses of 3 and 5 mm. T1 and T2-weighted MR images clearly depicted the normal porcine gastric walls as consisting of four distinct layers. In addition, vascular architectures in proper muscle layers were also visualized, which were confirmed by histological examinations to correspond to blood vessels. High-spatial-resolution MR imaging using a surface coil placed closely to the gastric wall enabled the differentiation of porcine gastric wall layers and the depiction of the blood vessels in proper muscle layer in this experimental study.

Newly developed surface coil for endoluminal MRI, depiction of pig gastric wall layers and vascular architecture in ex vivo study

International Nuclear Information System (INIS)

Morita, Yoshinori; Kutsumi, Hiromu; Yoshinaka, Hayato

2009-01-01

The purpose of this study was to visualize the gastric wall layers and to depict the vascular architecture in vitro by using resected porcine stomachs studied with high-spatial resolution magnetic resonance (MR) imaging. Normal dissected porcine stomach samples (n=4) were examined with a 3 Tesla MR system using a newly developed surface coil. MR images were obtained by the surface coil as receiver and a head coil as transmitter. High-spatial-resolution spin-echo MR images were obtained with a field of view of 8 x 8 cm, a matrix of 256 x 128 and slice thicknesses of 3 and 5 mm. T1 and T2-weighted MR images clearly depicted the normal porcine gastric walls as consisting of four distinct layers. In addition, vascular architectures in proper muscle layers were also visualized, which were confirmed by histological examinations to correspond to blood vessels. High-spatial-resolution MR imaging using a surface coil placed closely to the gastric wall enabled the differentiation of porcine gastric wall layers and the depiction of the blood vessels in proper muscle layer in this experimental study. (author)

Study on time properties of newly type inorganic scintillator cerium fluoride (CeF3)

International Nuclear Information System (INIS)

Hu Mengchun; Zhou Dianzhong; Guo Cun; Ye Wenying

2003-01-01

CeF 3 is a newly fast time response inorganic scintillator, the time characteristics of which, developed in recent country in nearly year were studied in our works. The time characteristics are rise time, FWHM time and fall time for fast pulse radiation source. As the same time, authors have calculated and used the formula of pulse method gain to the decay time constant of crystal shining, the decay time constant measured is the same to the results of foreign references

Identification of oligo-N-glycolylneuraminic acid residues in mammal-derived glycoproteins by a newly developed immunochemical reagent and biochemical methods.

Science.gov (United States)

Sato, C; Kitajima, K; Inoue, S; Inoue, Y

1998-01-30

The occurrence of the alpha2-->8-linked oligomeric form of N-glycolylneuraminic acid (oligo-Neu5Gc) residues in mammalian glycoproteins was unequivocally demonstrated using a newly developed anti-oligo/poly-Neu5Gc monoclonal antibody as well as by chemical and biochemical methods. First, the antibody, designated mAb.2-4B, which specifically recognized oligo/poly-Neu5Gc with a degree of polymerization of >2, was developed by establishing a hybridoma cell line from P3U1 myeloma cells fused with splenocytes from an MRL autoimmune mouse immunized with dipalmitoylphosphatidylethanolamine-conjugated oligo/poly-Neu5Gc. Second, oligo-Neu5Gc was shown to occur in glycoproteins derived from pig spleen by Western blot analysis using mAb.2-4B, which was also confirmed by fluorometric high performance liquid chromatographic analysis of the product of periodate oxidation/reduction/acid hydrolysis of the purified glycopeptide fractions and by TLC and 600-MHz 1H NMR spectroscopic analysis of their mild acid hydrolysates. Finally, the ubiquitous occurrence of oligo-Neu5Gc chains as glycoproteinaceous components in Wistar rat tissue was immunochemically indicated. This is the first example demonstrating the diversity in oligo/poly-Sia structure in mammalian glycoproteins, where only poly-N-acetylneuraminic acid is known to occur. Such diversity in oligo/poly-Sia structure also implicates a diverged array of biological functions of this glycan unit in glycoproteins.

Association of copeptin and cortisol in newly diagnosed multiple sclerosis patients.

Science.gov (United States)

Baranowska-Bik, Agnieszka; Kochanowski, Jan; Uchman, Dorota; Litwiniuk, Anna; Kalisz, Malgorzata; Martynska, Lidia; Wolinska-Witort, Ewa; Baranowska, Boguslawa; Bik, Wojciech

2015-05-15

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system. Obesity may increase the risk of developing MS. The aim of this study was to evaluate copeptin and cortisol plasma levels in newly diagnosed untreated MS patients and to determine whether copeptin and cortisol are related to the patients' clinical statuses. We report that copeptin and cortisol were higher in overweight/obese MS patients. Positive correlations were observed between the two parameters. We conclude that alterations of copeptin and cortisol levels in multiple sclerosis patients may be related to adiposity. An increase in cortisol may also be associated with copeptin secretion. Copyright © 2015 Elsevier B.V. All rights reserved.

Discrete stochastic processes and applications

CERN Document Server

Collet, Jean-François

2018-01-01

This unique text for beginning graduate students gives a self-contained introduction to the mathematical properties of stochastics and presents their applications to Markov processes, coding theory, population dynamics, and search engine design. The book is ideal for a newly designed course in an introduction to probability and information theory. Prerequisites include working knowledge of linear algebra, calculus, and probability theory. The first part of the text focuses on the rigorous theory of Markov processes on countable spaces (Markov chains) and provides the basis to developing solid probabilistic intuition without the need for a course in measure theory. The approach taken is gradual beginning with the case of discrete time and moving on to that of continuous time. The second part of this text is more applied; its core introduces various uses of convexity in probability and presents a nice treatment of entropy.

Patterns of Software Development Process

Directory of Open Access Journals (Sweden)

Sandro Javier Bolaños Castro

2011-12-01

Full Text Available "Times New Roman","serif";mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">This article presents a set of patterns that can be found to perform best practices in software processes that are directly related to the problem of implementing the activities of the process, the roles involved, the knowledge generated and the inputs and outputs belonging to the process. In this work, a definition of the architecture is encouraged by using different recurrent configurations that strengthen the process and yield efficient results for the development of a software project. The patterns presented constitute a catalog, which serves as a vocabulary for communication among project participants [1], [2], and also can be implemented through software tools, thus facilitating patterns implementation [3]. Additionally, a tool that can be obtained under GPL (General Public license is provided for this purpose

Investigation of the drying airflow at a newly developed dryer geometry for mixed flow grain dryers

Directory of Open Access Journals (Sweden)

Holger Scaar

2016-06-01

Full Text Available The mixed-flow dryer has been a matter of investigation many times regarding drying efficiency, dryer control, and performance enhancement over the past years. However, there is still considerable demand for optimization in terms of energy efficiency and homogeneity of drying. In order to analyze the specific energy consumption and the homogeneity of the drying process, different thermodynamic process conditions have been investigated for the conventional MFD design using numerical and experimental methods. Based on the results obtained, a novel dryer design has been developed. With this, a considerable increase of efficiency is expected. As the fluid dynamic analysis of the first design draft revealed, further development is required until scaling-up and transfer into practice will be possible. While homogeneous airflow conditions could be demonstrated in the core flow region in the center of the dryer, the configuration must be optimized in the near wall regions.

Identifying Malnutrition: Nutritional Status in Newly Diagnosed Patients With Cancer.

Science.gov (United States)

Krishnasamy, Karthikayini; Li Yoong, Tang; Mei Chan, Chong; Peng Choong, Lau; Chinna, Karuthan

2017-02-01

Malnutrition is common among patients with cancer, but little attention is given to its risks and consequences. The aim of this study is to assess the nutritional status and identify the factors associated with malnutrition among newly diagnosed patients with cancer. Patients admitted with newly diagnosed cancer at a teaching hospital in Malaysia were recruited from January to April 2015. Nutritional status was assessed before treatment initiation, and patients were classified into three categories. A total of 132 pretreatment patients were recruited into the study. About half were severely malnourished. Patients with stage III cancer had the highest prevalence of severe malnourishment. Clinical parameters and disease characteristics were significantly associated with nutritional status. Demographic variables were also statistically significantly associated with severe nutritional status.

Assessment of metal retention in newly constructed highway embankments.

Science.gov (United States)

Werkenthin, Moritz; Kluge, Björn; Wessolek, Gerd

2016-12-01

Newly constructed embankments should provide both a specific bearing capacity to enable trafficability in emergency cases and a sufficient pollutant retention capacity to protect the groundwater. A number of lysimeters were installed along the A115 highway to determine total and dissolved metal concentrations in road runoff and in the soil solution of newly constructed embankments. Dissolved concentrations in soil solution of the embankments did not exceed the trigger values of the German legislation. Depending on the metal, total concentrations in soil solution were more than twice as high as dissolved concentrations. The high infiltration rates lead to increased groundwater recharge beneath the embankments (up to 4100 mm a -1 ). Although metal concentrations were not problematic from the legislators' point of view, the elevated infiltration rates beside the road facilitated the transfer of high metal loads into deeper soil layers and potentially into the groundwater as well.

Experimental Studies on the Behavior of a Newly-Developed Type of Self-Insulating Concrete Masonry Shear Wall under in-Plane Cyclic Loading

Directory of Open Access Journals (Sweden)

Abu-Bakre Abdelmoneim Elamin Mohamad

2017-04-01

Full Text Available This study aimed to investigate the inelastic behavior of a newly-developed type of self-insulating concrete masonry shear wall (SCMSW under in-plane cyclic loading. The new masonry system was made from concrete blocks with special configurations to provide a stronger bond between units than ordinary concrete masonry units. A total of six fully-grouted SCMSWs were prepared with different heights (1.59 to 5.78 m and different vertical steel configurations. The developed masonry walls were tested under in-plane cyclic loading and different constant axial load ratios. In addition, the relationship between the amount of axial loading, the amount of the flexural reinforcement and the wall aspect ratios and the nonlinear hysteretic response of the SCMSW was evaluated. The results showed that the lateral load capacity of SCMSW increases with the amount of applied axial load and the amount of vertical reinforcement. However, the lateral load capacity decreases as the wall aspect ratio increases. The existence of the boundary elements at the SCMSW ends increases the ductility and the lateral load capacity. Generally, the SCMSW exhibited predominantly flexural behavior. These results agreed with those reported in previous research for walls constructed with ordinary units.

Workplace Violence and Job Outcomes of Newly Licensed Nurses.

Science.gov (United States)

Chang, Hyoung Eun; Cho, Sung-Hyun

2016-12-01

The purpose of this study was to examine the prevalence of workplace violence toward newly licensed nurses and the relationship between workplace violence and job outcomes. An online survey was conducted of newly licensed registered nurses who had obtained their license in 2012 or 2013 in South Korea and had been working for 5-12 months after first being employed. The sample consisted of 312 nurses working in hospitals or clinics. The Copenhagen Psychosocial Questionnaire II was used to measure violence and nurse job outcomes. Multiple linear and logistic regression analyses were conducted to examine the relationship between violence and job outcomes. Verbal abuse was most prevalent (59.6%), followed by threats of violence (36.9%), physical violence (27.6%), bullying (25.6%), and sexual harassment (22.4%). Approximately three quarters of the nurses had experienced at least one type of violence. The main perpetrators were patients and nurse colleagues, although the distribution of perpetrators varied depending on the type of violence. Bullying had a significant relationship with all four job outcomes (job satisfaction, burnout, commitment to the workplace, and intent to leave), while verbal abuse was associated with all job outcomes except for intent to leave. Violence perpetrated by nurse colleagues had a significant relationship with all four job outcomes, while violence by physicians had a significant inverse relationship with job satisfaction. Workplace violence is experienced by a high percentage of newly licensed nurses, and is associated with their job outcomes. Copyright © 2016. Published by Elsevier B.V.

A neuroconstructivist model of past tense development and processing.

Science.gov (United States)

Westermann, Gert; Ruh, Nicolas

2012-07-01

We present a neural network model of learning and processing the English past tense that is based on the notion that experience-dependent cortical development is a core aspect of cognitive development. During learning the model adds and removes units and connections to develop a task-specific final architecture. The model provides an integrated account of characteristic errors during learning the past tense, adult generalization to pseudoverbs, and dissociations between verbs observed after brain damage in aphasic patients. We put forward a theory of verb inflection in which a functional processing architecture develops through interactions between experience-dependent brain development and the structure of the environment, in this case, the statistical properties of verbs in the language. The outcome of this process is a structured processing system giving rise to graded dissociations between verbs that are easy and verbs that are hard to learn and process. In contrast to dual-mechanism accounts of inflection, we argue that describing dissociations as a dichotomy between regular and irregular verbs is a post hoc abstraction and is not linked to underlying processing mechanisms. We extend current single-mechanism accounts of inflection by highlighting the role of structural adaptation in development and in the formation of the adult processing system. In contrast to some single-mechanism accounts, we argue that the link between irregular inflection and verb semantics is not causal and that existing data can be explained on the basis of phonological representations alone. This work highlights the benefit of taking brain development seriously in theories of cognitive development. Copyright 2012 APA, all rights reserved.

Cognitive Process of Development in Children

Science.gov (United States)

Boddington, Eulalee N.

2009-01-01

In this article we explored the theories of Arnold Gesell, Erik Erickson and Jean Piaget about how human beings development. In this component we will analyze the cognitive processes of how children perceive and develop, in particular children from a cross-cultural background. How learning takes place, and how the influences of culture, and…

MCO closure welding process parameter development and qualification

International Nuclear Information System (INIS)

CANNELL, G.R.

2003-01-01

One of the key elements in the SNF process is final closure of the MCO by welding. Fuel is loaded into the MCO (approximately 2 ft. in diameter and 13 ft. long) and a heavy shield plug is inserted into the top, creating a mechanical seal. The plug contains several process ports for various operations, including vacuum drying and inert-gas backfilling of the packaged fuel. When fully processed, the Canister Cover Assembly (CCA) is placed over the shield plug and final closure made by welding. The following reports the effort between the Amer Industrial Technology (AIT) and Fluor Hanford (FH) to develop and qualify the welding process for making the final closure--with primary emphasis on developing a set of robust parameters for deposition of the root pass. Work was carried out in three phases: (1) Initial welding process and equipment selection with subsequent field demonstration testing; (2) Development and qualification of a specific process technique and parameters; and (3) Validation of the process and parameters at the CSB under mock production conditions. This work establishes the process technique and parameters that provide a high level of confidence that acceptable MCO closure welds will be made on a consistent and repeatable basis

Sustaining Innovation: Developing an Instructional Technology Assessment Process

Science.gov (United States)

Carmo, Monica Cristina

2013-01-01

This case study developed an instructional technology assessment process for the Gevirtz Graduate School of Education (GGSE). The theoretical framework of Adelman and Taylor (2001) guided the development of this instructional technology assessment process and the tools to aid in its facilitation. GGSE faculty, staff, and graduate students…

A perspective on PSE in pharmaceutical process development and innovation

DEFF Research Database (Denmark)

Gernaey, Krist; Cervera Padrell, Albert Emili; Woodley, John

2012-01-01

The pharmaceutical industry is under growing pressure to increase efficiency, both in production and in process development. This paper discusses the central role of Process Systems Engineering (PSE) methods and tools in pharmaceutical process development and innovation, and searches for answers...... to questions such as: Which PSE methods can be applied readily? Where is more method development needed? The paper covers key subjects for development of economically and environmentally sustainable pharmaceutical processes, including Process Analytical Technology in its broadest sense, continuous...... pharmaceutical manufacturing and green processes, and is illustrated with a series of short examples taken from the literature and ongoing research projects....

Developing a practice guideline for the occupational health services by using a community of practice approach: a process evaluation of the development process

Directory of Open Access Journals (Sweden)

Lydia Kwak

2017-01-01

Full Text Available Abstract Background One way to facilitate the translation of research into the occupational health service practice is through clinical practice guidelines. To increase the implementability of guidelines it is important to include the end-users in the development, for example by a community of practice approach. This paper describes the development of an occupational health practice guideline aimed at the management of non-specific low back pain (LBP by using a community of practice approach. The paper also includes a process evaluation of the development providing insight into the feasibility of the process. Methods A multidisciplinary community of practice group (n = 16 consisting of occupational nurses, occupational physicians, ergonomists/physical therapists, health and safety engineers, health educators, psychologists and researchers from different types of occupational health services and geographical regions within Sweden met eleven times (June 2012–December 2013 to develop the practice guideline following recommendations of guideline development handbooks. Process-outcomes recruitment, reach, context, satisfaction, feasibility and fidelity were assessed by questionnaire, observations and administrative data. Results Group members attended on average 7.5 out of 11 meetings. Half experienced support from their workplace for their involvement. Feasibility was rated as good, except for time-scheduling. Most group members were satisfied with the structure of the process (e.g. presentations, multidisciplinary group. Fidelity was rated as fairly high. Conclusions The described development process is a feasible process for guideline development. For future guideline development expectations of the work involved should be more clearly communicated, as well as the purpose and tasks of the CoP-group. Moreover, possibilities to improve support from managers and colleagues should be explored. This paper has important implications for future

Adult Personality Development: Dynamics and Processes

OpenAIRE

Diehl, Manfred; Hooker, Karen

2013-01-01

The focus of this special issue of Research in Human Development is on adult personality and how personality may contribute to and be involved in adult development. Specifically, the contributions in this issue focus on the links between personality structures (e.g., traits) and personality processes (e.g., goal pursuit, self--regulation) and emphasize the contributions that intensive repeated measurement approaches can make to the understanding of personality and development across the adult...

Development of Cloud Chamber by Using Peltier Device

International Nuclear Information System (INIS)

Woo, Jong Kwan; Kwon, Jin Young; Park, Sang Tae

2011-01-01

In this research, we developed the newly cloud chamber apparatus by using Peltier device to apply nuclear physics experiment in high school or university. We observed the cosmic rays track by using the developed apparatus and a camcorder. And we compared and analyzed the acquired data. From the results, we acquired the following conclusions and suggestions : First, it is very difficult to observe the cosmic rays track in the typical cloud chamber because of the low frequency of it. But in the newly developed cloud chamber we can observe easily the cosmic rays track owing to the high frequency of it. Second, when we do the experiment with the newly developed apparatus, we found that the cosmic rays track happens well under the condition that the temperature of the upper place of cooling plate must be below 5 degree Celsius with more than isopropanol 1.04X10 -5 ml.mm -3 . Third, the newly developed apparatus will be improved to have better precision by controlling the temperature of cooling plate in the cloud chamber by current intensity. Therefore we think that it is very useful to use the newly developed apparatus in the nuclear physics experiment in high school or university.

Development of Cloud Chamber by Using Peltier Device

Energy Technology Data Exchange (ETDEWEB)

Woo, Jong Kwan [Jae Hyun High School, Seoul (Korea, Republic of); Kwon, Jin Young [Jeon Min High School, Daejeon (Korea, Republic of); Park, Sang Tae [Dept. of Physics Education, Kongju National University, Kongju (Korea, Republic of)

2011-09-15

In this research, we developed the newly cloud chamber apparatus by using Peltier device to apply nuclear physics experiment in high school or university. We observed the cosmic rays track by using the developed apparatus and a camcorder. And we compared and analyzed the acquired data. From the results, we acquired the following conclusions and suggestions : First, it is very difficult to observe the cosmic rays track in the typical cloud chamber because of the low frequency of it. But in the newly developed cloud chamber we can observe easily the cosmic rays track owing to the high frequency of it. Second, when we do the experiment with the newly developed apparatus, we found that the cosmic rays track happens well under the condition that the temperature of the upper place of cooling plate must be below 5 degree Celsius with more than isopropanol 1.04X10{sup -5}ml.mm{sup -3}. Third, the newly developed apparatus will be improved to have better precision by controlling the temperature of cooling plate in the cloud chamber by current intensity. Therefore we think that it is very useful to use the newly developed apparatus in the nuclear physics experiment in high school or university.

Review of Exploration Systems Development (ESD) Integrated Hazard Development Process. Appendices; Volume 2

Science.gov (United States)

Smiles, Michael D.; Blythe, Michael P.; Bejmuk, Bohdan; Currie, Nancy J.; Doremus, Robert C.; Franzo, Jennifer C.; Gordon, Mark W.; Johnson, Tracy D.; Kowaleski, Mark M.; Laube, Jeffrey R.

2015-01-01

The Chief Engineer of the Exploration Systems Development (ESD) Office requested that the NASA Engineering and Safety Center (NESC) perform an independent assessment of the ESD's integrated hazard development process. The focus of the assessment was to review the integrated hazard analysis (IHA) process and identify any gaps/improvements in the process (e.g. missed causes, cause tree completeness, missed hazards). This document contains the outcome of the NESC assessment.

Review of Exploration Systems Development (ESD) Integrated Hazard Development Process. Volume 1; Appendices

Science.gov (United States)

Smiles, Michael D.; Blythe, Michael P.; Bejmuk, Bohdan; Currie, Nancy J.; Doremus, Robert C.; Franzo, Jennifer C.; Gordon, Mark W.; Johnson, Tracy D.; Kowaleski, Mark M.; Laube, Jeffrey R.

2015-01-01

The Chief Engineer of the Exploration Systems Development (ESD) Office requested that the NASA Engineering and Safety Center (NESC) perform an independent assessment of the ESD's integrated hazard development process. The focus of the assessment was to review the integrated hazard analysis (IHA) process and identify any gaps/improvements in the process (e.g., missed causes, cause tree completeness, missed hazards). This document contains the outcome of the NESC assessment.

Chenodeoxycholic acid reduces intestinal permeability in newly weaned piglets

NARCIS (Netherlands)

Meer, van der Y.; Gerrits, W.J.J.; Bosch, van den M.; Holst, J.J.; Moreto, M.; Buurman, W.A.; Kulik, W.; Kempen, van T.A.T.G.

2012-01-01

Piglets are highly susceptible to gut health-related problems. Intravenously administered chenodeoxycholic acid (CDCA) affects gut health mediated through glucagon-like peptide 2 (GLP-2). To test whether CDCA is a suitable feed additive for improving gut health, a trial was performed with newly

Radioisotope waste processing systems

International Nuclear Information System (INIS)

Machida, Tadashi

1978-01-01

The Atomic Energy Safety Bureau established the policy entitled ''On Common Processing System of Radioactive Wastes'' consulting with the Liaison Committee of Radioactive Waste Processing. Japan Atomic Energy Research Institute (JAERI) and Japan Radioisotope Association (JRIA) had been discussing the problems required for the establishment of the common disposal facilities based on the above policy, and they started the organization in spring, 1978. It is a foundation borrowing equipments from JAERI though installing newly some of them not available from JAERI, and depending the fund on JRIA. The operation expenses will be borne by those who want to dispose the wastes produced. The staffs are sent out from JAERI and JRIA. For animal wastes contaminated with RI, formaldehyde dipping should be abolished, but drying and freezing procedures will be taken before they are burnt up in a newly planned exclusive furnace with disposing capacity of 50 kg/hour. To settle the problems of other wastes, enough understanding and cooperation of users are to be requested. (Kobatake, H.)

Timing of revenue streams from newly recruited faculty: implications for faculty retention.

Science.gov (United States)

Joiner, Keith A; Hiteman, Sarah; Wormsley, Steven; St Germain, Patricia

2007-12-01

To determine the timing and magnitude of revenues generated by newly recruited faculty, to facilitate configuration of recruitment packages appropriately matched to expected financial returns. The aggregate of all positive cash flows to central college of medicine administration -- from research, clinical care, tuition, philanthropy, and royalties and patents, from all faculty newly recruited to the University of Arizona College of Medicine between 1998 and 2004 -- was quantified using the net present value (npv) methodology, which incorporates the time value of money. Tenure-track faculty and, in particular, those with laboratory research programs, generated the highest positive central cash flows. The npv for positive cash flows (npv[+]) during 6 and 10 years for newly recruited assistant professors with laboratory research programs were $118,600 and $255,400, respectively, and, for professors with laboratory research programs, $172,600 and $298,000, respectively (associate professors were not analyzed because of limited numbers). Faculty whose appointments at the University of Arizona College of Medicine exceeded 15 years in duration were the most productive in central revenue generation, far in excess of their numbers proportionate to the total. The results emphasize the critical importance of faculty retention, because even those newly recruited faculty who are most successful in central revenue generation (tenure track with laboratory research programs) must be retained for periods well in excess of 10 years to recoup the initial central investment required for their recruitment.

Process Techno – Innovation Using TQM in Developing Countries

Directory of Open Access Journals (Sweden)

Fasil Taddese

2010-08-01

Full Text Available Techno-innovation has been competitive edge for most manufacturing companies. Rapid advancement in technology-innovation geared-up with global mega-competition has resulted in unprecedented economic growth where TQM has played major role. Despite slow economic growth in developing countries caused by incapability to develop their own technology, failure to make wise decision in adopting competent technology, and inability to properly utilize adopted technologies; tremendous developments are seen in some. Examples can be Indian companies that won the prestigious Deming Prize and Japan Quality Medal after adopting necessary technologies from Japan under TQM. We have addressed process techno-innovation by 4M (Man, Machine, Method, Material and 1E (working condition-corporate culture approach. Results indicate that TQM affects process techno-innovation by primary effect on human resource and working condition/corporate culture. Three stage gates vis-à-vis: process understanding, process improvement and technology learning, and process techno-innovation are the mechanisms through which TQM promotes process techno-innovation in developing countries.

'BRICS without straw'? A systematic literature review of newly emerging economies' influence in global health.

Science.gov (United States)

Harmer, Andrew; Xiao, Yina; Missoni, Eduardo; Tediosi, Fabrizio

2013-04-15

Since 2010, five newly emerging economies collectively known as 'BRICS' (Brazil, India, Russia, China and South Africa) have caught the imagination, and scholarly attention, of political scientists, economists and development specialists. The prospect of a unified geopolitical bloc, consciously seeking to re-frame international (and global) health development with a new set of ideas and values, has also, if belatedly, begun to attract the attention of the global health community. But what influence, if any, do the BRICS wield in global health, and, if they do wield influence, how has that influence been conceptualized and recorded in the literature? We conducted a systematic literature review in (March-December 2012) of documents retrieved from the databases EMBASE, PubMed/Medline, Global Health, and Google Scholar, and the websites of relevant international organisations, research institutions and philanthropic organisations. The results were synthesised using a framework of influence developed for the review from the political science literature. Our initial search of databases and websites yielded 887 documents. Exclusion criteria narrowed the number of documents to 71 journal articles and 23 reports. Two researchers using an agreed set of inclusion criteria independently screened the 94 documents, leaving just 7 documents. We found just one document that provided sustained analysis of the BRICS' collective influence; the overwhelming tendency was to describe individual BRICS countries influence. Although influence was predominantly framed by BRICS countries' material capability, there were examples of institutional and ideational influence - particularly from Brazil. Individual BRICS countries were primarily 'opportunity seekers' and region mobilisers but with potential to become 'issue leaders' and region organisers. Though small in number, the written output on BRICS influence in global health has increased significantly since a similar review conducted in

Improving new product development (NPD process by analyzing failure cases

Directory of Open Access Journals (Sweden)

Yeon-Hak Kim

2017-01-01

Full Text Available Purpose - The purpose of this study is to develop an appropriate new product development (NPD process of Company “T”, a medium-sized firm, by analyzing the existing NPD process and failure cases of the Company. Design/methodology/approach - The proposed research framework is as follows: first, prospective studies of the NPD process are performed using the existing literature and preliminary references; second, comparative analysis between the current processes and a NPD process is performed; third, phase-based evaluations upon failed product cases are conducted with a NPD process so as to identify the abridged steps and root-causes of failures; finally, renewed priorities are set forth by utilizing the analytic hierarchy process analysis and questionnaire analysis upon the above identified causes of failures. Findings - The resulting accomplishments include the establishment of NPD processes that resonates with the current states of Company “T”, which, in turn, ensures the increase of efficiency, the decrease in development duration and the strategy of capacity-concentration and priority-selection. Originality/value - As Company “T”’s development process is outdated and products are developed without adequate market information research and feasibility analysis, the percentage of failed development project is as high as 87 per cent. Thus, this study aims to develop an appropriate NPD process of Company “T” by analyzing the existing NPD process and failure cases of the Company.

Distinguishing Newly Born Strange Stars from Neutron Stars with g-Mode Oscillations

International Nuclear Information System (INIS)

Fu Weijie; Wei Haiqing; Liu Yuxin

2008-01-01

The gravity-mode (g-mode) eigenfrequencies of newly born strange quark stars (SQSs) and neutron stars (NSs) are studied. It is found that the eigenfrequencies in SQSs are much lower than those in NSs by almost 1 order of magnitude, since the components of a SQS are all extremely relativistic particles while nucleons in a NS are nonrelativistic. We therefore propose that newly born SQSs can be distinguished from the NSs by detecting the eigenfrequencies of the g-mode pulsations of supernovae cores through gravitational radiation by LIGO-class detectors

The Process of Trust Development

DEFF Research Database (Denmark)

Jagd, Søren; Højland, Jeppe

in management among employees. Trust is found to be higher among employees interacting regularly with managers, as in the project coordination group. It is found that personal relations are very important for the development of trust. The success of the project may be explained by the involvement of an ‘elite...... and discuss with colleagues from other departments and develop personal knowledge of each other....... by high trust and co-operation? In this paper we explore the process of trust development during an organisational change project in a Danish SME by looking at two kinds of trust relations: employee trust in management and trust relations among employees. We find substantial differences in trust...

High-power ultrasonic processing: Recent developments and prospective advances

Science.gov (United States)

Gallego-Juarez, Juan A.

2010-01-01

Although the application of ultrasonic energy to produce or to enhance a wide variety of processes have been explored since about the middle of the 20th century, only a reduced number of ultrasonic processes have been established at industrial level. However, during the last ten years the interest in ultrasonic processing has revived particularly in industrial sectors where the ultrasonic technology may represent a clean and efficient tool to improve classical existing processes or an innovation alternative for the development of new processes. Such seems to be the case of relevant sectors such as food industry, environment, pharmaceuticals and chemicals manufacture, machinery, mining, etc where power ultrasound is becoming an emerging technology for process development. The possible major problem in the application of high-intensity ultrasound on industrial processing is the design and development of efficient power ultrasonic systems (generators and reactors) capable of large scale successful operation specifically adapted to each individual process. In the area of ultrasonic processing in fluid media and more specifically in gases, the development of the steppedplate transducers and other power ge with extensive radiating surface has strongly contributed to the implementation at semi-industrial and industrial stage of several commercial applications, in sectors such as food and beverage industry (defoaming, drying, extraction, etc), environment (air cleaning, sludge filtration, etc...), machinery and process for manufacturing (textile washing, paint manufacture, etc). The development of different cavitational reactors for liquid treatment in continuous flow is helping to introduce into industry the wide potential of the area of sonochemistry. Processes such as water and effluent treatment, crystallization, soil remediation, etc have been already implemented at semi-industrial and/or industrial stage. Other single advances in sectors like mining or energy have

The lived experience of newly qualified radiographers (1950-1985): An oral history of radiography

International Nuclear Information System (INIS)

Decker, Sola

2009-01-01

The preparedness for practice of newly qualified healthcare professionals (including radiographers) has been the focus of attention in recent years as the practice environment continues to place great demands on its workforce. This paper reports an aspect of the findings from an oral history project on the career history of radiographers conducted as an academic research investigating the changes that have occurred in radiography and the impact these have had on the profession and the practice of radiography. The main focus of this paper is the lived experience of the informants of the oral history project as newly qualified radiographers. The findings are discussed in the context of current practice environment and developments in radiography. Analysis of the textual materials generated from informants' oral historical accounts, suggest radiographers trained in this time frame perceived their training as 'fit for purpose. The findings further suggest there is a general norm of 'get-on-with-it' as a coping strategy which is still prevalent in the profession today. The paper concludes by drawing on lessons that can be learned from the lived experiences of radiographers' oral historical accounts.

A Software Development Simulation Model of a Spiral Process

OpenAIRE

Carolyn Mizell; Linda Malone

2009-01-01

This paper will present a discrete event simulation model of a spiral development lifecycle that can be used to analyze cost and schedule effects of using such a process in comparison to a waterfall process. There is a need for simulation models of software development processes other than the waterfall due to new processes becoming more widely used in order to overcome the limitations of the traditional waterfall lifecycle. The use of a spiral process can make the inherently difficult job of...

Development, validation and routine control of a radiation process

International Nuclear Information System (INIS)

Kishor Mehta

2010-01-01

Today, radiation is used in industrial processing for variety of applications; from low doses for blood irradiation to very high doses for materials modification and even higher for gemstone colour enhancement. At present, radiation is mainly provided by either radionuclides or machine sources; cobalt-60 is the most predominant radionuclide in use. Currently, there are several hundred irradiation facilities worldwide. Similar to other industries, quality management systems can assist radiation processing facilities in enhancing customer satisfaction and maintaining and improving product quality. To help fulfill quality management requirements, several national and international organizations have developed various standards related to radiation processing. They all have requirements and guidelines for development, validation and routine control of the radiation process. For radiation processing, these three phases involve the following activities. Development phase includes selecting the type of radiation source, irradiation facility and the dose required for the process. Validation phase includes conducting activities that give assurance that the process will be successful. Routine control then involves activities that provide evidence that the process has been successfully realized. These standards require documentary evidence that process validation and process control have been followed. Dosimetry information gathered during these processes provides this evidence. (authors)

Development of Processed Products from Guapple

Directory of Open Access Journals (Sweden)

Teresita Acevedo

1995-12-01

Full Text Available The study aimed to develop processed products from guapple. Characterization of the guapple fruit was intially conducted before proceeding to formulation studies.The following characteristics of the guapple fruit were observed: color of outer skin - yellow green with Munsell notation of 10 Y7/6, color of inner flesh - off white with Munsell notation of 7.5Y 8/2; texture, 20.4-37.1 mm; average weight per piece, from 219 to 420 gms; ph, 3.7; titrable acidity (citric acid, 0.34%, and soluble solids, 2.6° Brix.The identified processed products from guapple were puree, pickles, and preserves. Standardized processes and formulations for each of these products were developed in semi-pilot scale. Removal of the skin for the guapple preserves and pickles was facilitated using 5% brine-l % CaCI2.Suitable packaging materials were also identified. Flexible films were used for guapple puree while glass jars and flexible films were found to be satisfactory both for guapple pickles and preserves.Physico-chemical, microbiological, and sensory evaluation were done after two months of storage. Based on these tests, the pasteurization process of 180° F for 20 minutes for puree and 10 minutes for preserves and pickles, was found to make the products commercially sterile.

Biocatalytic process development using microfluidic miniaturized systems

DEFF Research Database (Denmark)

Krühne, Ulrich; Heintz, Søren; Ringborg, Rolf Hoffmeyer

2014-01-01

The increasing interest in biocatalytic processes means there is a clear need for a new systematic development paradigm which encompasses both protein engineering and process engineering. This paper argues that through the use of a new microfluidic platform, data can be collected more rapidly...

Newly Discovered Ebola Virus Associated with Hemorrhagic Fever Outbreak in Uganda

Science.gov (United States)

Towner, Jonathan S.; Sealy, Tara K.; Khristova, Marina L.; Albariño, César G.; Conlan, Sean; Reeder, Serena A.; Quan, Phenix-Lan; Lipkin, W. Ian; Downing, Robert; Tappero, Jordan W.; Okware, Samuel; Lutwama, Julius; Bakamutumaho, Barnabas; Kayiwa, John; Comer, James A.; Rollin, Pierre E.; Ksiazek, Thomas G.; Nichol, Stuart T.

2008-01-01

Over the past 30 years, Zaire and Sudan ebolaviruses have been responsible for large hemorrhagic fever (HF) outbreaks with case fatalities ranging from 53% to 90%, while a third species, Côte d'Ivoire ebolavirus, caused a single non-fatal HF case. In November 2007, HF cases were reported in Bundibugyo District, Western Uganda. Laboratory investigation of the initial 29 suspect-case blood specimens by classic methods (antigen capture, IgM and IgG ELISA) and a recently developed random-primed pyrosequencing approach quickly identified this to be an Ebola HF outbreak associated with a newly discovered ebolavirus species (Bundibugyo ebolavirus) distantly related to the Côte d'Ivoire ebolavirus found in western Africa. Due to the sequence divergence of this new virus relative to all previously recognized ebolaviruses, these findings have important implications for design of future diagnostic assays to monitor Ebola HF disease in humans and animals, and ongoing efforts to develop effective antivirals and vaccines. PMID:19023410

Switching industrial production processes from complex to defined media: method development and case study using the example of Penicillium chrysogenum.

Science.gov (United States)

Posch, Andreas E; Spadiut, Oliver; Herwig, Christoph

2012-06-22

Filamentous fungi are versatile cell factories and widely used for the production of antibiotics, organic acids, enzymes and other industrially relevant compounds at large scale. As a fact, industrial production processes employing filamentous fungi are commonly based on complex raw materials. However, considerable lot-to-lot variability of complex media ingredients not only demands for exhaustive incoming components inspection and quality control, but unavoidably affects process stability and performance. Thus, switching bioprocesses from complex to defined media is highly desirable. This study presents a strategy for strain characterization of filamentous fungi on partly complex media using redundant mass balancing techniques. Applying the suggested method, interdependencies between specific biomass and side-product formation rates, production of fructooligosaccharides, specific complex media component uptake rates and fungal strains were revealed. A 2-fold increase of the overall penicillin space time yield and a 3-fold increase in the maximum specific penicillin formation rate were reached in defined media compared to complex media. The newly developed methodology enabled fast characterization of two different industrial Penicillium chrysogenum candidate strains on complex media based on specific complex media component uptake kinetics and identification of the most promising strain for switching the process from complex to defined conditions. Characterization at different complex/defined media ratios using only a limited number of analytical methods allowed maximizing the overall industrial objectives of increasing both, method throughput and the generation of scientific process understanding.

Newly qualified doctors' views on the significance and accessibility of career advice during medical training in Saudi Arabia.

Science.gov (United States)

Mehmood, Syed Imran; Norcini, John J; Borleffs, Jan C C

2013-01-01

Career advice is an important instrument to help students with the proper specialty selection. The study aims (1) to explore the views of newly graduated doctors in Saudi Arabia about their experience with the current status of career support system during medical training and (2) to identify cross-cultural similarities and differences. A cross-sectional design study was conducted using a questionnaire to elicit the responses of participants from newly qualified doctors concerning the availability and significance of career advice. SPSS (version 11.0; Chicago, IL) was used to analyze the data and statistical tests, such as chi-square and unpaired t tests, were used to analyze the observations. A response rate of 94.7% was obtained. Among this group, 102 were males and 78 were females. Only 53% did receive career advice. The majority of men felt that career advice during medical studies was inadequate, while women were less negative (69% versus 32%; p = 0.0001). Furthermore, men were more disappointed about the possibilities for career advice after graduating than women (34% versus 13%, p = 0.0001). The results show that only half of newly graduated doctors had received any career advice during medical training. As the health care system cannot afford the potential waste of time and resources for doctors, career guidance should begin in undergraduate training so that the process of thinking about their future career starts longtime before they make their career choice.

Sustainable Chemical Process Development through an Integrated Framework

DEFF Research Database (Denmark)

Papadakis, Emmanouil; Kumar Tula, Anjan; Anantpinijwatna, Amata

2016-01-01

This paper describes the development and the application of a general integrated framework based on systematic model-based methods and computer-aided tools with the objective to achieve more sustainable process designs and to improve the process understanding. The developed framework can be appli...... studies involve multiphase reaction systems for the synthesis of active pharmaceutical ingredients....

Development of Diamond-like Carbon Fibre Wheel

Institute of Scientific and Technical Information of China (English)

魏源迁; 山口勝美; 洞口巌; 竹内雅之

2004-01-01

A unique diamond-like carbon (DLC) grinding wheel was developed, in which the DLC fibres were made by rolling Al sheets coated with DLC films and aligned normally to the grinding wheel surface by laminating Al sheets together with DLC fibres. In this paper, the formation process of DLC fibres and the fabrication process of a DLC fibre wheel were investigated. Many grinding experiments were also carried out on a precision NC plane milling machine using a newly developed DLC wheel. Grinding of specimens of silicon wafers, optical glasses, quartz, granites and hardened die steel SKD11 demonstrated the capabilities of nanometer surface finish. A smooth surface with a roughness value of Ra2.5nm (Ry26nm) was achieved.

Development of advanced spent fuel management process. System analysis of advanced spent fuel management process

International Nuclear Information System (INIS)

Ro, S.G.; Kang, D.S.; Seo, C.S.; Lee, H.H.; Shin, Y.J.; Park, S.W.

1999-03-01

The system analysis of an advanced spent fuel management process to establish a non-proliferation model for the long-term spent fuel management is performed by comparing the several dry processes, such as a salt transport process, a lithium process, the IFR process developed in America, and DDP developed in Russia. In our system analysis, the non-proliferation concept is focused on the separation factor between uranium and plutonium and decontamination factors of products in each process, and the non-proliferation model for the long-term spent fuel management has finally been introduced. (Author). 29 refs., 17 tabs., 12 figs

Process Development for Nanostructured Photovoltaics

Energy Technology Data Exchange (ETDEWEB)

Elam, Jeffrey W.

2015-01-01

Photovoltaic manufacturing is an emerging industry that promises a carbon-free, nearly limitless source of energy for our nation. However, the high-temperature manufacturing processes used for conventional silicon-based photovoltaics are extremely energy-intensive and expensive. This high cost imposes a critical barrier to the widespread implementation of photovoltaic technology. Argonne National Laboratory and its partners recently invented new methods for manufacturing nanostructured photovoltaic devices that allow dramatic savings in materials, process energy, and cost. These methods are based on atomic layer deposition, a thin film synthesis technique that has been commercialized for the mass production of semiconductor microelectronics. The goal of this project was to develop these low-cost fabrication methods for the high efficiency production of nanostructured photovoltaics, and to demonstrate these methods in solar cell manufacturing. We achieved this goal in two ways: 1) we demonstrated the benefits of these coatings in the laboratory by scaling-up the fabrication of low-cost dye sensitized solar cells; 2) we used our coating technology to reduce the manufacturing cost of solar cells under development by our industrial partners.

A comprehensive literature review of guidelines facilitating transition of newly graduated nurses to professional nurses.

Science.gov (United States)

van Rooyen, Dalena R M; Jordan, Portia J; Ten Ham-Baloyi, Wilma; Caka, Ernestina M

2018-05-01

Literature shows that successful transition of newly graduate nurses to professional nurses is imperative but does not always take place, resulting in difficulty in performance, cognizance or behaviour of a role as a nurse, affecting the quality of patient care negatively. No integrative literature review could be found to summarize available guidelines facilitating transition of final year nursing students to professional nurses. An extensive search of the literature by means of an integrative literature review was conducted in 2014 and updated in June 2017, following a five-step process. All relevant studies were subsequently appraised for rigour and quality using the AGREE II tool by two independent reviewers. Eight (n = 8) guidelines on transitions were independently extracted. After thematic analysis was done, three factors to facilitate transition of final year nursing students to professional nurses were found: 1) support for new graduates, 2) the graduate's need for socialization and belonging, and 3) a positive clinical learning environment. The availability and implementation of guidelines on transition of final year nursing students by educational institutions and healthcare facilities could ease the transition from being final year nursing students to becoming professional nurses as well as improve retention of newly qualified professional nurses. Copyright © 2018. Published by Elsevier Ltd.

Cytological Evaluation and REBA HPV-ID HPV Testing of Newly Developed Liquid-Based Cytology, EASYPREP: Comparison with SurePath.

Science.gov (United States)

Lee, Youn Soo; Gong, Gyungyub; Sohn, Jin Hee; Ryu, Ki Sung; Lee, Jung Hun; Khang, Shin Kwang; Cho, Kyung-Ja; Kim, Yong-Man; Kang, Chang Suk

2013-06-01

The objective of this study was to evaluate a newly-developed EASYPREP liquid-based cytology method in cervicovaginal specimens and compare it with SurePath. Cervicovaginal specimens were prospectively collected from 1,000 patients with EASYPREP and SurePath. The specimens were first collected by brushing for SurePath and second for EASYPREP. The specimens of both methods were diagnosed according to the Bethesda System. Additionally, we performed to REBA HPV-ID genotyping and sequencing analysis for human papillomavirus (HPV) on 249 specimens. EASYPREP and SurePath showed even distribution of cells and were equal in cellularity and staining quality. The diagnostic agreement between the two methods was 96.5%. Based on the standard of SurePath, the sensitivity, specificity, positive predictive value, and negative predictive value of EASYPREP were 90.7%, 99.2%, 94.8%, and 98.5%, respectively. The positivity of REBA HPV-ID was 49.4% and 95.1% in normal and abnormal cytological samples, respectively. The result of REBA HPV-ID had high concordance with sequencing analysis. EASYPREP provided comparable results to SurePath in the diagnosis and staining quality of cytology examinations and in HPV testing with REBA HPV-ID. EASYPREP could be another LBC method choice for the cervicovaginal specimens. Additionally, REBA HPV-ID may be a useful method for HPV genotyping.

Effect of Annealing Temperature on the Mechanical and Corrosion Behavior of a Newly Developed Novel Lean Duplex Stainless Steel.

Science.gov (United States)

Guo, Yanjun; Hu, Jincheng; Li, Jin; Jiang, Laizhu; Liu, Tianwei; Wu, Yanping

2014-09-12

The effect of annealing temperature (1000-1150 °C) on the microstructure evolution, mechanical properties, and pitting corrosion behavior of a newly developed novel lean duplex stainless steel with 20.53Cr-3.45Mn-2.08Ni-0.17N-0.31Mo was studied by means of optical metallographic microscopy (OMM), scanning electron microscopy (SEM), magnetic force microscopy (MFM), scanning Kelvin probe force microscopy (SKPFM), energy dispersive X-ray spectroscopy (EDS), uniaxial tensile tests (UTT), and potentiostatic critical pitting temperature (CPT). The results showed that tensile and yield strength, as well as the pitting corrosion resistance, could be degraded with annealing temperature increasing from 1000 up to 1150 °C. Meanwhile, the elongation at break reached the maximum of 52.7% after annealing at 1050 °C due to the effect of martensite transformation induced plasticity (TRIP). The localized pitting attack preferentially occurred at ferrite phase, indicating that the ferrite phase had inferior pitting corrosion resistance as compared to the austenite phase. With increasing annealing temperature, the pitting resistance equivalent number (PREN) of ferrite phase dropped, while that of the austenite phase rose. Additionally, it was found that ferrite possessed a lower Volta potential than austenite phase. Moreover, the Volta potential difference between ferrite and austenite increased with the annealing temperature, which was well consistent with the difference of PREN.

Development of the four group partitioning process at JAERI

International Nuclear Information System (INIS)

Kubota, Masumitsu; Morita, Yasuji; Yamaguchi, Isoo; Yamagishi, Isao; Fujiwara, T.; Watanabe, Masayuki; Mizoguchi, Kenichi; Tatsugae, Ryozo

1999-01-01

At JAERI, development of a partitioning method started about 24 years ago. From 1973 to 1984, a partitioning process was developed for separating elements in HLLW into 3 groups; TRU, Sr-Cs and others. The partitioning process consisted of three steps; solvent extraction of U and Pu with TBP, solvent extraction of Am and Cm with DIDPA, and adsorption of Sr and Cs with inorganic ion exchangers. The process was demonstrated with real HLLW. Since 1985, a four group partitioning process has been developed, in which a step for separating the Tc-PGM group was developed in addition to the three group separation. Effective methods for separating TRU, especially Np, and Tc have been developed. In this paper, the flow sheet of the four group partitioning and the results of tests with simulated and real HLLW in NUCEF hot-cell are shown. (J.P.N.)

The Development and Current State of Translation Process Research

DEFF Research Database (Denmark)

Lykke Jakobsen, Arnt

2014-01-01

The development and current state of translation process research ch Arnt Lykke Jakobsen Copenhagen Business School lInterest in process-oriented translation studies has been intense for the past almost half a century. Translation process research (TPR) is the label we have used to refer to a spe...... itself, into regions like cognitive psychology, psycho- and neurolinguistics, and neuroscience, where the interest in what goes on in our heads is also very strong.......The development and current state of translation process research ch Arnt Lykke Jakobsen Copenhagen Business School lInterest in process-oriented translation studies has been intense for the past almost half a century. Translation process research (TPR) is the label we have used to refer...... which simultaneously tracks the translator’s eye movements across a screen displaying both a source text and the translator’s emerging translation. This research method was developed as a means of qualifying and strengthening translation process hypotheses based on verbal reports by providing additional...

A terrestrial ecosystem model (SOLVEG) coupled with atmospheric gas and aerosol exchange processes

International Nuclear Information System (INIS)

Katata, Genki; Ota, Masakazu

2017-01-01

In order to predict the impact of atmospheric pollutants (gases and aerosols) to the terrestrial ecosystem, new schemes for calculating the processes of dry deposition of gases and aerosols, and water and carbon cycles in terrestrial ecosystems were implemented in the one-dimensional atmosphere-SOiL-VEGetation model, SOLVEG. We made performance tests at various vegetation areas to validate the newly developed schemes. In this report, the detail in each modeled process is described with an instruction how to use the modified SOLVEG. The framework of 'terrestrial ecosystem model' was developed for investigation of a change in water, energy, and carbon cycles associated with global warming and air pollution and its impact on terrestrial ecosystems. (author)

[Psycho-social factors of sexual failure among newly married Uyghur young males].

Science.gov (United States)

Erkin, Ashim; Hamrajan, Memtili; Kadirjan, Mijit; Adil, Eli; Elijan, Abdureshit; Ibrahim, Ubul; Abdulla, Tursun; Hasanjan, Abdurehim; Turgun, Hekim; Eli, Ablet; Eset, Metmusa

2016-08-01

To study the psycho-social risk factors of sexual failure among newly married young males in the Uyghur population. We conducted a paired case control study of 186 newly married Uyghur young males (aged 17－30 ［23.4±2.9］ yr) with sexual failure and another 186 (aged 18－34 ［24.0±3.1］ yr) with no such problem as controls. We performed a logistic regression analysis on the possible psycho-social risk factors of this condition. Logistic regression analysis showed that the risk factors of sexual failure among the newly married men included personality (OR=0.271, 95% CI 0.176－0.420), income (OR=0.391, 95% CI 0.264－0.580), history of masturbation (OR=0.824, 95% CI 0.710－0.956), premarital sex (OR=0.757, 95% CI 0.677－0.847), sense of obligation (OR=1.756, 95% CI 1.157－2.693), equality of the social status (OR=0.574, 95% CI 0.435－0.756), degree of mutual care (OR=1.605, 95% CI 1.268－2.032), female's psychological obstacle (OR=2.832, 95% CI 1.221－6.569), and religion (OR=0.643, 95% CI 0.472－0.967). There was a statistical significance in the correlation between these factors and sexual failure in the newly married males (all Ppsycho-social factors, which necessitates sexual education among young males and particularly pre-marriage sexual education and psychological guide among both males and females.

Three newly recorded Linyphiid spiders (Araneae: Linyphiidae from Korea

Directory of Open Access Journals (Sweden)

Sue Yeon Lee

2018-03-01

Full Text Available Three Linyphiid spiders, Caviphantes pseudosaxetorum Wunderlich, 1979, Erigone edentata Saito and Ono, 2001, and Savignia kawachiensis Oi, 1960, are reported for the first time from Korea with taxonomic illustrations and redescription. In this study, the genus Caviphantes Oi, 1960 is also newly recorded to Korean spider fauna.

Rational and systematic protein purification process development: the next generation.

Science.gov (United States)

Nfor, Beckley K; Verhaert, Peter D E M; van der Wielen, Luuk A M; Hubbuch, Jürgen; Ottens, Marcel

2009-12-01

Current biopharmaceutical manufacturing strongly relies on using purification platform processes, offering harmonization of practices and speed-to-market. However, the ability of such processes to respond quickly to anticipated higher quality and capacity demands is under question. Here, we describe novel approaches for purification process development that incorporate biothermodynamics, modern high throughput experimentation and simulation tools. Such development leads to production platform-specific databases containing thermodynamic protein descriptors of major host cell proteins over a range of experimental conditions. This will pave the way for in silico purification process development, providing better process understanding and the potential to respond quickly to product quality and market demands. Future efforts will focus on improving this field further and enabling more rationale in process development.

[Impact of Increased Supply of Newly Licensed Nurses on Hospital Nurse Staffing and Policy Implications].

Science.gov (United States)

Kim, Yunmi; You, Sunju; Kim, Jinhyun

2017-12-01

This study aimed to analyze the impact of increasing the supply of newly licensed nurses on improving the hospital nurse staffing grades for the period of 2009~2014. Using public administrative data, we analyzed the effect of newly licensed nurses on staffing in 1,594 hospitals using Generalized Estimating Equation (GEE) ordered logistic regression, and of supply variation on improving staffing grades in 1,042 hospitals using GEE logistic regression. An increase of one newly licensed nurse per 100 beds in general units had significantly lower odds of improving staffing grades (grades 6~0 vs. 7) (odds ratio=0.95, p=.005). The supply of newly licensed nurses increased by 32% from 2009 to 2014, and proportion of hospitals whose staffing grade had improved, not changed, and worsened was 19.1%, 70.1%, and 10.8% respectively. Compared to 2009, the supply variation of newly licensed nurses in 2014 was not significantly related to the increased odds of improving staffing grades in the region (OR=1.02, p=.870). To achieve a balance in the regional supply and demand for hospital nurses, compliance with nurse staffing legislation and revisions in the nursing fee differentiation policy are needed. Rather than relying on increasing nurse supply, retention policies for new graduate nurses are required to build and sustain competent nurse workforce in the future. © 2017 Korean Society of Nursing Science

Process-Based Quality (PBQ) Tools Development; TOPICAL

International Nuclear Information System (INIS)

Cummins, J.L.

2001-01-01

The objective of this effort is to benchmark the development of process-based quality tools for application in CAD (computer-aided design) model-based applications. The processes of interest are design, manufacturing, and quality process applications. A study was commissioned addressing the impact, current technologies, and known problem areas in application of 3D MCAD (3-dimensional mechanical computer-aided design) models and model integrity on downstream manufacturing and quality processes. The downstream manufacturing and product quality processes are profoundly influenced and dependent on model quality and modeling process integrity. The goal is to illustrate and expedite the modeling and downstream model-based technologies for available or conceptual methods and tools to achieve maximum economic advantage and advance process-based quality concepts

Biomedical signal and image processing.

Science.gov (United States)

Cerutti, Sergio; Baselli, Giuseppe; Bianchi, Anna; Caiani, Enrico; Contini, Davide; Cubeddu, Rinaldo; Dercole, Fabio; Rienzo, Luca; Liberati, Diego; Mainardi, Luca; Ravazzani, Paolo; Rinaldi, Sergio; Signorini, Maria; Torricelli, Alessandro

2011-01-01

Generally, physiological modeling and biomedical signal processing constitute two important paradigms of biomedical engineering (BME): their fundamental concepts are taught starting from undergraduate studies and are more completely dealt with in the last years of graduate curricula, as well as in Ph.D. courses. Traditionally, these two cultural aspects were separated, with the first one more oriented to physiological issues and how to model them and the second one more dedicated to the development of processing tools or algorithms to enhance useful information from clinical data. A practical consequence was that those who did models did not do signal processing and vice versa. However, in recent years,the need for closer integration between signal processing and modeling of the relevant biological systems emerged very clearly [1], [2]. This is not only true for training purposes(i.e., to properly prepare the new professional members of BME) but also for the development of newly conceived research projects in which the integration between biomedical signal and image processing (BSIP) and modeling plays a crucial role. Just to give simple examples, topics such as brain–computer machine or interfaces,neuroengineering, nonlinear dynamical analysis of the cardiovascular (CV) system,integration of sensory-motor characteristics aimed at the building of advanced prostheses and rehabilitation tools, and wearable devices for vital sign monitoring and others do require an intelligent fusion of modeling and signal processing competences that are certainly peculiar of our discipline of BME.

Feasibility and effects of newly developed balance control trainer for mobility and balance in chronic stroke patients: a randomized controlled trial.

Science.gov (United States)

Lee, So Hyun; Byun, Seung Deuk; Kim, Chul Hyun; Go, Jin Young; Nam, Hyeon Uk; Huh, Jin Seok; Jung, Tae Du

2012-08-01

To investigate the feasibility and effects of balance training with a newly developed Balance Control Trainer (BCT) that applied the concept of vertical movement for the improvements of mobility and balance in chronic stroke patients. Forty chronic stroke patients were randomly assigned to an experimental or a control group. The experimental group (n=20) underwent training with a BCT for 20 minutes a day, 5 days a week for 4 weeks, in addition to concurrent conventional physical therapy. The control group (n=20) underwent only conventional therapy for 4 weeks. All participants were assessed by: the Functional Ambulation Categories (FAC), 10-meter Walking Test (10mWT), Timed Up and Go test (TUG), Berg Balance Scale (BBS), Korean Modified Barthel Index (MBI), and Manual Muscle Test (MMT) before training, and at 2 and 4 weeks of training. There were statistically significant improvements in all parameters except knee extensor power at 2 weeks of treatment, and in all parameters except MBI which showed further statistically significant progress in the experimental group over the next two weeks (pgait in ambulatory chronic stroke patients. Furthermore, it may provide additional benefits when used in conjunction with conventional therapies.

Materials, processes, and environmental engineering network

Science.gov (United States)

White, Margo M.

1993-01-01

The Materials, Processes, and Environmental Engineering Network (MPEEN) was developed as a central holding facility for materials testing information generated by the Materials and Processes Laboratory. It contains information from other NASA centers and outside agencies, and also includes the NASA Environmental Information System (NEIS) and Failure Analysis Information System (FAIS) data. Environmental replacement materials information is a newly developed focus of MPEEN. This database is the NASA Environmental Information System, NEIS, which is accessible through MPEEN. Environmental concerns are addressed regarding materials identified by the NASA Operational Environment Team, NOET, to be hazardous to the environment. An environmental replacement technology database is contained within NEIS. Environmental concerns about materials are identified by NOET, and control or replacement strategies are formed. This database also contains the usage and performance characteristics of these hazardous materials. In addition to addressing environmental concerns, MPEEN contains one of the largest materials databases in the world. Over 600 users access this network on a daily basis. There is information available on failure analysis, metals and nonmetals testing, materials properties, standard and commercial parts, foreign alloy cross-reference, Long Duration Exposure Facility (LDEF) data, and Materials and Processes Selection List data.

Hope in newly diagnosed cancer patients.

Science.gov (United States)

Duggleby, Wendy; Ghosh, Sunita; Cooper, Dan; Dwernychuk, Lynne

2013-11-01

Hope is important to cancer patients as it helps them deal with their diagnosis. Little is known about hope in newly diagnosed cancer patients. Based on the Transcending Possibilities conceptual model of hope, the purpose of this study was to examine the relationship of hope with pain, energy, and psychological and demographic characteristics in newly diagnosed adult oncology outpatients. Data from 310 New Patient Assessment Forms from cancer outpatients' health records were collected. Health records from the first six months of 2009 were reviewed and data were collected on hope, energy, pain, depression, anxiety, feeling overwhelmed, and demographic variables. A generalized linear modeling approach was used to study the relationship of hope scores with these variables. Hypothesized variables and variables that were significant at the P = 0.01 level from the univariate analysis were entered into the multivariate model, with hope scores as the dependent variable. Hope scores were significantly negatively related to age (P = 0.02). More specifically, oncology patients who were 65 years of age or older had significantly less hope than those under the age of 65 years (P = 0.01). Gender (P = 0.009) also was a significant factor, with men having higher hope scores than women. No other variables were significant. Older adults comprise the majority of persons in Canada with cancer. The lower hope scores found in this age group compared with their younger counterparts underscore the importance of further research. This study provides a foundation for future research in this important area for oncology patients. Copyright © 2013 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.

Different Pathophysiological Phenotypes among Newly Diagnosed Type 2 Diabetes Patients

DEFF Research Database (Denmark)

Stidsen, Jacob

2013-01-01

Type 2 diabetes (T2D) can be considered a syndrome with several different pathophysiological mechanisms leading to hyperglycemia. Nonetheless, T2D is treated according to algorithms as if it was one disease entity. Methods: We investigated the prevalence of different pathophysiological phenotypes...... or secondary diabetes), classic obesity-associated insulin resistant diabetes ( f-P-C-peptide >= 568 pmol/l) and a normoinsulinopenic group (333 age of our new T2D patients was 61 years (range 21-95 years), 57% were men. We found that 3.0% newly diagnosed T2D patients...... suffered from LADA, 3.9% from secondary diabetes, 6.0% from steroid induced diabetes 5.9% had insulinopenic diabetes, whereas 56.7% presented the classic obesity-associated insulin-resistant phenotype. 24.6% was classified as normoinsulinopenic patients. Conclusion: We conclude that newly diagnosed T2D...

cisTEM, user-friendly software for single-particle image processing