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Sample records for new-generation flexible ureteroscope

  1. Evaluation of the mechanisms of damage to flexible ureteroscopes and suggestions for ureteroscope preservation

    Institute of Scientific and Technical Information of China (English)

    P. Sooriakumaran; R. Kaba; H. O. Andrews; N. P. N. Buchholz

    2005-01-01

    Aim: To investigate the causes and costs of flexible ureteroscope damage, and to develop recommendations to limit damage. Methods: The authors analysed repair figures and possible causes of damage to 35 instruments sent for repair to a leading UK supplier over a 1-year period, and calculated cost figures for maintenance of the instruments as opposed to repair and replacement costs. Results: All damages were handling-induced and therefore did not fall under the manufacturer's warranty: 28 % were damaged by misfiring of the laser inside the instrument; 72 %, mainly crushing and stripping of the ureteroscope shaft tube, were likely to have occurred during out-of-surgery handling, washing and disinfection. Seventeen (4 %) instruments were not repaired and consequently taken out of service due to the extensive costs involved. Eighteen (51%) ureteroscopes were repaired at an average cost of 10 833 USD. Conclusion: Damages to flexible ureteroscopes bear considerable costs. Most damages occur during handling between surgical procedures.Thorough adherence to handling procedures, and courses for theater staff and surgeons on handling flexible instruments may help to reduce these damages and prove a cost-saving investment. The authors provide a list of recommended procedural measures that may help to prevent such damages.

  2. Flexible Ureteroscopic Management of Horseshoe Kidney Renal Calculi

    Directory of Open Access Journals (Sweden)

    Jie Ding

    2015-08-01

    Full Text Available ABSTRACTPurpose:To evaluate the clinical efficacy of flexible ureteroscope (F-URS combined with holmium laser lithotripter in treating renal calculi in horseshoe kidney.Materials and Methods:From November 2010 to December 2013, the medical history and charts of sixteen patients (mean age 42.9±11.6 years, range 26-66 years, including 13 males and 3 females were analyzed retrospectively. Mean stone burden was 29±8 mm (range 17-42 mm2. Mean stone digitized surface area (DSA was 321±94 mm2 (range 180-538 mm2. Under spinal anesthesia in a modified lithotomy position with the head down, rigid ureteroscope was placed firstly into the ureter to reach the level of the pelvis, a zebra guide wire was inserted and following the removal of the rigid ureteroscope, an ureteral access sheath was positioned along the guide wire, then passed the URF P-5 flexible ureteroscope into the renal cavities over the guidewire. After locating the stones, holmium laser lithotripsy was performed.Results:The average operative time was 92±16 minutes (range 74-127 min.. No major complications were encountered. Ten patients obtained stone-free status with one session, four obtained stone-free status after two sessions. Single session stone-free rate was 62.5%, overall stone-free rate was 87.5%. Two patients have small residual stones in the lower pole.Conclusions:F-URS combined with holmium laser lithotripter and nitinol basket, is safe and effective in dealing with moderate stone diameter (<30 mm in HSKs with high clearance rates and low complication rates.

  3. Defining the Costs of Reusable Flexible Ureteroscope Reprocessing Using Time-Driven Activity-Based Costing.

    Science.gov (United States)

    Isaacson, Dylan; Ahmad, Tessnim; Metzler, Ian; Tzou, David T; Taguchi, Kazumi; Usawachintachit, Manint; Zetumer, Samuel; Sherer, Benjamin; Stoller, Marshall; Chi, Thomas

    2017-09-20

    Careful decontamination and sterilization of reusable flexible ureteroscopes used in ureterorenoscopy cases prevent the spread of infectious pathogens to patients and technicians. However, inefficient reprocessing and unavailability of ureteroscopes sent out for repair can contribute to expensive operating room (OR) delays. Time-driven activity-based costing (TDABC) was applied to describe the time and costs involved in reprocessing. Direct observation and timing were performed for all steps in reprocessing of reusable flexible ureteroscopes following operative procedures. Estimated times needed for each step by which damaged ureteroscopes identified during reprocessing are sent for repair were characterized through interviews with purchasing analyst staff. Process maps were created for reprocessing and repair detailing individual step times and their variances. Cost data for labor and disposables used were applied to calculate per minute and average step costs. Ten ureteroscopes were followed through reprocessing. Process mapping for ureteroscope reprocessing averaged 229.0 ± 74.4 minutes, whereas sending a ureteroscope for repair required an estimated 143 minutes per repair. Most steps demonstrated low variance between timed observations. Ureteroscope drying was the longest and highest variance step at 126.5 ± 55.7 minutes and was highly dependent on manual air flushing through the ureteroscope working channel and ureteroscope positioning in the drying cabinet. Total costs for reprocessing totaled $96.13 per episode, including the cost of labor and disposable items. Utilizing TDABC delineates the full spectrum of costs associated with ureteroscope reprocessing and identifies areas for process improvement to drive value-based care. At our institution, ureteroscope drying was one clearly identified target area. Implementing training in ureteroscope drying technique could save up to 2 hours per reprocessing event, potentially preventing expensive OR delays.

  4. Which ureteral access sheath is compatible with your flexible ureteroscope?

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    Al-Qahtani, Saeed M; Letendre, Julien; Thomas, Alexandre; Natalin, Ricardo; Saussez, Thibaud; Traxer, Olivier

    2014-03-01

    Our aim is to evaluate different ureteral access sheaths (UASs), which are available in the international market and their compatibility with different available flexible ureteroscopes (F-URSs) to help the urologist choose the proper ureteral access sheath for his or her endoscope before commencing the procedure. A total of 21 UASs and 12 F-URSs were evaluated. Measurements were obtained in French (F) units considering different characteristics for each UAS and each F-URS. Insertion test without friction between F-URS and UAS was considered as a successful test and was referred as (YES). All UASs and F-URSs were successfully submitted to the insertion test. All F-URSs that were inserted into UASs without friction had an internal diameter of at least 12F. Different lengths of UAS did not influence the test outcome. This study was able to establish a correlation table between different UASs and different flexible ureteroscopes. As of now, the 12/14F UAS is considered the universal UAS that accepts all F-URSs that are available in the endourology field. Nevertheless, we are expecting a significant change with the new standard size 10/12F UAS as well as huge advances in minimizing the size of different endoscopes.

  5. Flexible ureteroscopic lithotripsy for the treatment of upper urinary tract calculi in infants.

    Science.gov (United States)

    Li, Jun; Xiao, Jing; Han, Tiandong; Tian, Ye; Wang, Wenying; Du, Yuan

    2017-01-01

    We evaluated the clinical value of flexible ureteroscopic lithotripsy for the treatment of upper urinary tract calculi in infants. Fifty-five infants with upper urinary tract calculi were included in this study: 41 males and 14 females. Retrograde intrarenal surgery was performed by an 8 Fr/30 cm flexible ureterorenoscope (POLY®) combined with a holmium laser. CT scanning or radiography of the kidneys, ureters, and bladder region was performed one month after the operation to confirm the clearance of calculi. All the 55 infants with calculi in 74 sides underwent 66 flexible ureteroscopic lithotripsy procedures. The median operation time was 30 min. The median amount of flushing fluid was 500 mL. The stone-free rate after a single session treatment was 94.6%, within which 10 infants underwent simultaneous bilateral flexible ureteroscopy lithotripsy. Catheters were retained in 45 infants for 24-48 h after the operation. Continuous high fever due to reflux was present in two cases. Flushing fluid extravasation was found in one infant. Some patients with minor complications, such as mild hematuria, irritation symptoms, and low fever, recovered without treatment. The duration of hospitalization time after the operation was approximately 1-5 days. Flexible ureteroscopic lithotripsy is a safe, highly efficient, minimally invasive, and reproducible operation for removal of upper urinary tract calculi in infants. This technique is a convenient method for postoperative management of patients that enhances their rapid recovery. It is a promising option for therapy of infants ineffectively treated by extracorporeal shockwave lithotripsy.

  6. New-generation flexible ureterorenoscopes are more durable than previous ones.

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    Traxer, Olivier; Dubosq, Francis; Jamali, Karim; Gattegno, Bernard; Thibault, Philippe

    2006-08-01

    To determine the deterioration in the maximal active deflection and flow capabilities of a new-generation flexible ureteroscope (URS). We performed 50 ureterorenoscopies using the same URS: a Karl Storz 11278 AU1 Flex-X, which is capable of a 270 degree active deflection in the ventral and dorsal directions. Postoperatively, we evaluated the maximal active ventral and dorsal deflection, irrigation flow at 100 cm H2O, and the number of broken optical fibers. The URS was used for a total of 76 hours, 15 minutes (average 95 minutes per procedure). The maximal ventral deflection had deteriorated from 270 degrees to 208 degrees at the last procedure. The maximal dorsal deflection had decreased from 270 degrees to 133 degrees. The irrigation flow at 100 cm H2O had decreased from 50 mL/min initially to 40 mL/min at the last procedure. The number of broken image fibers had reached six at the 50th procedure. One repair was necessary at the 50th procedure because of a laser perforation of the working channel. The need for repair occurs less frequently with the new-generation of URSs, especially when they are used by an experienced endourologist. In the future, improvements in the durability of the flexible URS will still be key for widespread use of the technique and especially to limit damage by the laser to the working channel.

  7. Outcomes of flexible ureteroscopic lithotripsy with holmium laser for upper urinary tract calculi

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    Marcello Cocuzza

    2008-03-01

    Full Text Available OBJECTIVE: To assess the perioperative and financial outcomes of flexible ureteroscopic lithotripsy with holmium laser for upper tract calculi in 44 patients. MATERIALS AND METHODS: Between February 2004 and September 2006, 44 patients treated for upper tract stone with flexible ureteroscopic lithotripsy were evaluated. Renal stones were associated with collecting system obstruction in 15 (34% patients, failed extracorporeal shock-wave lithotripsy (SWL occurred in 14 (32% patients, unilateral multiple stones in 18 (41% patients, and multiple bilateral stones in 3 (7%. In 29 (66% patients, the stone was located in the inferior calyx. Perioperative and financial outcomes were also evaluated. RESULTS: 50 procedures were performed in 44 patients. The mean stone burden on preoperative CT scan was 11.5 ± 5.8 mm. The mean operative time was 61.3 ± 29.4 min. The stone free rate was 93.1% after one procedure and 97.7% after a second procedure, with overall complication rate of 8%. Therapeutic success occurred in 92% and 93% of patients with lower pole stones and SWL failure, respectively. Treatment failure of a single session was associated with presence of a stone size larger than 15 mm (p = 0.007, but not associated with inferior calyx location (p = 0.09. Surgical disposables were responsible for 78% of overall costs. CONCLUSION: Flexible ureteroscopy using holmium laser is a safe and effective option for the treatment of upper urinary tract calculi. In addition, it can be considered an attractive option as salvage therapy after SWL failure or kidney calculi associated with ureteral stones. Stone size larger than 15 mm is associated with single session treatment failure.

  8. The comparative study of clinical efficacy between the flexible ureteroscope combination of rigid ureteroscope and the percutaneous nephrolithotomy holmium laser lithotripsy for the treatment of renal pelvis stones%输尿管软镜联合硬镜与经皮肾镜钬激光治疗肾盂大结石临床疗效对比研究

    Institute of Scientific and Technical Information of China (English)

    杨健; 傅发军

    2013-01-01

    目的 输尿管软镜联合硬镜与经皮肾镜钬激光治疗肾盂大结石临床疗效对比研究.方法 回顾和分析本院2010年7月~2012年8月应用输尿管软镜联合硬镜碎石术治疗肾盂大结石33例与采用经皮肾镜钬激光治疗肾盂大结石37例的治疗效果对比.结果 采用输尿管软镜结合硬镜碎石术治疗肾盂大结石的碎石率为95.3%,高于经皮肾镜钬激光法碎石术的90.5%.输尿管软镜结合硬镜的碎石排净时间为12d,显著少于经皮肾镜钬激光碎石术的14d.结论 采用输尿管软镜结合硬镜碎石术治疗肾盂大结石临床效果相比于经皮肾镜钬激光碎石术较好.%Objectives The comparison of clinical efficacy studies between the flexible ureteroscope combination of rigid ureteroscope and the percutaneous nephrolithotomy holmium laser lithotripsy for the treatment of renal pelvis stones.Methods To review and analysis the contrast between the flexible ureteroscope combination of rigid ureteroscope lithotripsy for the treatment of renal pelvis stones in 33 cases,and the percutaneous nephrolithotomy holmium laser lithotripsy for treatment of the renal pelvis stones in 37 cases at our hospital in July 2010 to August 2012.Results The flexible ureteroscope combination of rigid ureteroscope lithotripsy for the treatment of renal pelvis stones gravel was 95.3%,higher than the 90.5% from the ureteroscopic combined with the transcutaneous nerve holmium laser lithotripsy.The flexible ureteroscope combined with the rigid ureteroscope lithotripsy gravel clear time is 12d,significantly less than the 14d for the percutaneous nephrolithotomy holmium laser lithotripsy.Conclusions The clinical effect of flexible ureteroscope combined with rigid ureteroscope lithotripsy for the treatment of renal pelvis stones is better than the percutaneous nephrolithotomy holmium laser lithotripsy.

  9. First clinical evaluation of a new single-use flexible ureteroscope (LithoVue™)

    DEFF Research Database (Denmark)

    Doizi, Steeve; Kamphuis, Guido; Giusti, Guido

    2017-01-01

    patients included underwent flexible ureteroscopy and were 18 years or older. Deflection and image quality pre- and post-use and maneuverability were rated with a Likert scale. RESULTS: A total of 40 procedures were performed (five per institution). The indication for FURS was treatment of renal stones...

  10. Should flexible ureteroscope be added to our armamentarium to treat stone disease?

    Directory of Open Access Journals (Sweden)

    Anand Dharaskar

    2008-01-01

    Full Text Available The field of Urology in Medicine has witnessed tremendous advancement in technology and in accordance with it. Endourology has taken a leap ahead in terms of stone management. Most of the stones could be treated with semi-rigid ureteroscopy, percutaneous nephrolithotomy (PNL and ESWL and some would need Flexible ureteroscopy. Flexible ureteroscopy has been primarily indicated to treat ESWL resistant renal stones but with changes in the technology of incorporating secondary active deflection and availability of laser fibres, its horizon for indications to treat stones is being widened. Though Flexible ureteroscopy is being used to treat stones of various sizes and locations, its cost effectiveness is debatable. Should it be used ubiquitously to treat stones amenable to PNL or ESWL is a big question we need to answer. As of now true indications of Flexible ureteroscopy are limited and there is an urgent need for a randomized trial to compare its efficacy with ESWL and PNL for renal and upper ureteric stones.

  11. Flexible ureteroscope in the treatment of residual calculus after open surgery%输尿管软镜治疗开放手术残余结石

    Institute of Scientific and Technical Information of China (English)

    杨健; 傅发军

    2012-01-01

    目的 观察输尿管软镜治疗开放手术后残余结石的临床效果,探讨输尿管软镜在治疗术后残余结石中的应用价值.方法 选取我院2010年6月~2011年10月收治的106例开放手术治疗肾、输尿管结石后残余结石患者作为研究对象,所有患者均采用输尿管软镜钬激光碎石联合套石篮取石术,按照结石直径大小分为两组,A组(结石直径0.05).A组56例患者单次碎石成功47例,单次碎石成功率为83.9%,其余9例患者行再次碎石后均成功,总成功率为100.0%;B组50例患者单次碎石成功36例,单次碎石成功率为72.0%,其余14例患者行再次碎石后均成功,总成功率为100.0%,两组患者单次碎石成功率差异有高度统计学意义(P0.05),且两组均无并发症发生.结论 输尿管软镜治疗开放手术后残余结石效果理想,具有安全性高的特点,尤其适合结石直径小的患者,值得推广应用.%Objective To observe the clinical effects of flexible ureteroscope in the treatment of residual calculus after open surgery, and to explore the value of flexible ureteroscope in the treatment of postoperative residual calculus. Methods 106 cases of patients with residual calculus after open surgical treatment of kidney stones and urctera] calculus were selected as the objects of the study in our hospital from June 2010 to October 2011. All patients were treated with flexible ureteroscope holmium laser lithotripsy combined with stone basket lithotripsy. According to calculus diameters, all patients were divided into two groups, group A (calculus diameters 0.05). Among 56 patients of group A, 47 cases were successful in cmshing calculus In the first surgery, the success rate was 83.9%, and the other 9 patients were successful in crushing calculus in the second surgery, the total success rate was 100.0%. Among 50 patients of group B, 36 cases were successful In crushing calculus in the first surgery, the success rate was 72.0%, and the other

  12. Development and validation of a new generation of flexible endoscope for NOTES.

    Science.gov (United States)

    Swanström, Lee; Swain, Paul; Denk, Peter

    2009-06-01

    The concept of intraperitoneal flexible endoscopy has created much interest and investigation. Both gastroenterologists with a surgical leaning and surgeons with advanced endoscopy interests are researching the feasibility of this new approach. Current flexible scopes and instruments are extremely limited for use in natural orifice transluminal endoscopic surgery (NOTES). We describe the development of an endoscopic system specifically designed for endoluminal and NOTES procedures and demonstrates benefits and efficacy in benchtop and cadaver models. In conjunction with industry, an 18-mm 4-channel rigidizing access device was designed. Measurements of the strength (torsional and lifting) of standard endoscopes and the new scope were made. The new device and instruments are used in 8 cadavers to document its feasibility in a variety of specific tasks: endoluminal plication, upper abdomen and lower abdomen visualization, bowel manipulation, solid organ retraction, cholecystectomy, and enterotomy closure. Benchtop comparison between a standard scope and the new scope showed equal maneuverability but the newer scope had greater force delivery at the tip (0.042 vs 1.96 lb, P instrument application force (0.09 vs 0.23 lb, P < .002). Introduction of the scope was possible in all cadavers but difficult in cadavers <60 kg. Intragastric manipulation was feasible and exiting the stomach was possible although it required a 2-cm gastrotomy. The scope system was maneuverable in both lower quadrants without difficulty. The upper abdomen was viewable, with variable success in steering the scope between left and right quadrants. The entire gastrointestinal tract was able to be visualized in most cadavers. The scope generated sufficient force to lift and manipulate intraabdominal structures. Cholecystectomy was successful in 5 of 5 attempts. A new flexible access endoscope with 4 large access channels showed utility in a cadaver model-satisfying some of the requirements for

  13. A new generation active arrays for optical flexibility in astronomical instrumentation

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    Kroes, G.; Jaskó, A.; Pragt, J. H.; Venema, L.; De Haan, M.

    2012-09-01

    Throughout the history of telescopes and astronomical instrumentation, new ways were found to open up unexplored possibilities in fundamental astronomical research by increasing the telescope size and instrumentation complexity. The ever demanding requirements on instrument performance pushes instrument complexity to the edge. In order to take the next leap forward in instrument development the optical design freedom needs to be increased drastically. The use of more complex and more accurate optics allows for shorter optical trains with smaller sizes, smaller number of components and reduced fabrication and alignment verification time and costs. Current optics fabrication is limited in surface form complexity and/or accuracy. Traditional active and adaptive optics lack the needed intrinsic long term stability and simplicity in design, manufacturing, verification and control. This paper explains how and why active arrays literally provide a flexible but stable basis for the next generation optical instruments. Combing active arrays with optically high quality face sheets more complex and accurate optical surface forms can be provided including extreme a-spherical (freeform) surfaces and thus allow for optical train optimization and even instrument reconfiguration. A zero based design strategy is adopted for the development of the active arrays addressing fundamental issues in opto-mechanical engineering. The various choices are investigated by prototypes and Finite Element Analysis. Finally an engineering concept will be presented following a highly stable adjustment strategy allowing simple verification and control. The Optimization metrology is described in an additional paper for this conference by T. Agócs et al.

  14. 铂立组合式输尿管软镜联合钬激光碎石术治疗肾结石的疗效观察%Curative observation of polyscope modular flexible ureteroscope combined with Holmium laser lithotripsy in the treatment of renal calculi

    Institute of Scientific and Technical Information of China (English)

    鄢俊安; 邓国贤; 郑霁; 宋思吉; 李前伟; 姚基伟; 代林勇; 李为兵; 周占松

    2014-01-01

    Objective To evaluate the curative effect of polyscope modular flexible ureteroscope combined with Holmium laser lithotrip-sy in the treatment of renal calculi. Methods 53 patients with renal calculi were performed CTU to detect the position of renal calculi before operation. The patients were treated with polyscope modular flexible ureteroscope combined with Holmium laser, and the double J tube were routinely indwelled 4 to 12 weeks after surgery. Results All the 52 patients has successfully completed the operation in the frist stage. The mean operative time was about 38 minutes. 6 patients were treated with flexible ureteroscope for second stage operation. One week after oper-ation, the review showed that there were residual calculi existed in 24 cases and there were 56 cases of post-operative infection, including 17 cases of sepsis or sepsis shock. Conclusion Polyscope modular flexible ureteroscope can be used for all kinds of kidney stones surgery and is characterized by safety and mild tissue injury. But we should pay more attention to the post-operative infection especially urosepsis.%目的:探讨使用铂立组合式输尿管软镜联合钬激光治疗肾结石的疗效。方法58例肾结石患者,经术前尿路造影( CTU)定位,采用输尿管软镜联合钬激光碎石,术后留置双J管4~12周。结果52例一期完成手术,平均手术时间38 min左右,6例行二期软镜治疗,术后1周复查有24例结石残留,56例术后发生感染,其中17例脓毒症/脓毒症休克。结论铂立组合式输尿管软镜能较好完成各类肾结石手术,损伤小,但伴发的感染尤其是脓毒症要引起足够重视。

  15. Risk factors of a decreased stone free rate after flexible ureteroscopic lithotripsy%输尿管软镜碎石术后结石清除率降低的风险因素分析

    Institute of Scientific and Technical Information of China (English)

    钟文; 赖贺; 赵志健; 曾国华

    2016-01-01

    目的:评估影响输尿管软镜碎石术(flexible ureteroscopic lithotripsy,FUL)术后结石清除率(stone freerate,SFR)的风险因素.方法:分析260例FUL患者临床资料,将患者特征(年龄、性别、BMI、病史等)、结石特点(大小、位置和相关肾脏解剖、成分等)、FUL参数(输尿管通道鞘、灌注、碎石时间和手术时间等)作为潜在风险因素分组进行单因素分析,随后通过多因素逻辑回归分析,计算Odds比值(OR)和95%可信区间(95% CI),以确定FUL术后SFR降低的独立风险因素.结果:本组FUL术后SFR为73.5%.多因素逻辑回归分析中,结石大小(OR=8.636,95%CI:4.594~16.236,P<0.001)、肾下盏结石(OR=9.892,95%CI:4.463~21.923,P<0.001)、经皮肾镜取石(PCNL)术后残留结石(OR=4.632,95%CI:1.715~12.512,P=0.002)及感染性结石(OR=2.302,95%CI:1.000~5.305,P=0.050)被确定为FUL术后SFR降低的独立风险因素.结论:对于大负荷结石、肾下盏结石、PCNL术后残留结石、感染性结石,FUL术后SFR将会有降低的风险.

  16. Combined electrohydraulic and holmium: YAG laser ureteroscopic nephrolithotripsy of large (>2 cm) renal calculi.

    Science.gov (United States)

    Mariani, Albert J

    2008-10-01

    Percutaneous nephrolithotripsy (PCL) is a standard treatment for renal calculi >2 cm. Modern flexible ureteroscopes and accessories employing the complementary effects of electrohydraulic lithotripsy (EHL) and Ho:YAG laser lithotrites can treat these renal calculi in a minimally invasive fashion with similar or superior results. To assess the safety and efficacy of ureteroscopic nephrolithotripsy monotherapy for the management of >2 cm renal calculi in the community setting. Fifty nine patients with 63 renal calculi ranging from 20 to 97 mm (mean 44 mm) in length and 175 to 3300 mm2 (mean 728 mm2) area underwent staged ureteroscopic nephrolithotripsy monotherapy. Obesity (BMI > 30) was present in 54% and 19% were morbidly obese (BMI > 40). An infectious etiology was present in 49% and hard stone components in 89%. All patients presented with hematuria, pain, and/or recurrent urinary tract infection (UTI). Lithotripsy was performed with a single deflection flexible ureteroscope and predominantly EHL. Laser drilling was employed (n = 6) to weaken very hard stones prior to EHL. Low intrarenal pressure was maintained by continuous bladder drainage and placement of a stiff safety wire. Visibility was maintained using manual pulsatile irrigation. All patients were rendered pain and infection-free. No patient required a blood transfusion and there was no change in serum creatinine. Mobile stone-free status was achieved in 60/63 (95%) with a mean of 1.7 nephrolithotripsy stages and 0.38 secondary or ancillary procedures. Outpatient management was sufficient for 121/131 (92%) of the procedures. Operative time averaged 46 min/stage and 79 min/calculus. Complications included endotoxic shock (3), fever (5), ureteral fragments requiring treatment (11), delayed extubation (2), delayed pneumonia (1), and urinary retention (1). Staged ureteroscopic nephrolithotripsy of large renal calculi is feasible with low morbidity and stone clearance rates that compare favorably with PCL. It

  17. Combined electrohydraulic and holmium: YAG laser ureteroscopic nephrolithotripsy of large (>2 cm renal calculi

    Directory of Open Access Journals (Sweden)

    Albert J Mariani

    2008-01-01

    Full Text Available Percutaneous nephrolithotripsy (PCL is a standard treatment for renal calculi> 2 cm. Modern flexible ureteroscopes and accessories employing the complementary effects of electrohydraulic lithotripsy (EHL and Ho:YAG laser lithotrites can treat these renal calculi in a minimally invasive fashion with similar or superior results. Objective: To assess the safety and efficacy of ureteroscopic nephrolithotripsy monotherapy for the management of> 2 cm renal calculi in the community setting. Materials and Methods: Fifty nine patients with 63 renal calculi ranging from 20 to 97 mm (mean 44 mm in length and 175 to 3300 mm2 (mean 728 mm2 area underwent staged ureteroscopic nephrolithotripsy monotherapy. Obesity (BMI > 30 was present in 54% and 19% were morbidly obese (BMI > 40. An infectious etiology was present in 49% and hard stone components in 89%. All patients presented with hematuria, pain, and/or recurrent urinary tract infection (UTI. Lithotripsy was performed with a single deflection flexible ureteroscope and predominantly EHL. Laser drilling was employed (n = 6 to weaken very hard stones prior to EHL. Low intrarenal pressure was maintained by continuous bladder drainage and placement of a stiff safety wire. Visibility was maintained using manual pulsatile irrigation. Results: All patients were rendered pain and infection-free. No patient required a blood transfusion and there was no change in serum creatinine. Mobile stone-free status was achieved in 60/63 (95% with a mean of 1.7 nephrolithotripsy stages and 0.38 secondary or ancillary procedures. Outpatient management was sufficient for 121/131 (92% of the procedures. Operative time averaged 46 min/stage and 79 min/calculus. Complications included endotoxic shock (3, fever (5, ureteral fragments requiring treatment (11, delayed extubation (2, delayed pneumonia (1, and urinary retention (1. Conclusion: Staged ureteroscopic nephrolithotripsy of large renal calculi is feasible with low morbidity

  18. 输尿管软镜下钬激光碎石术治疗上尿路结石——附126例报告%Treatment of Upper Urinary Calculi with Holmium Laser Lithotriptor under Flexible Ureteroscope (Appended with Report of 126 Cases)

    Institute of Scientific and Technical Information of China (English)

    周振宇; 何朝晖; 杨江根; 曾国华

    2013-01-01

    Objective To evaluate the clinical effect of holmium laser with flexible ureteroscope on upper urinary calculi.Methods All 126 patients of upper urinary calculi were treated with Holmium laser lithotriptor under flexible ureteroscope in our hospital.Of them,75 patients had calculi in the right side and 51 patients in the left side.The calculi were in the kidney for 64 patients,in the upper ureteral for 33 patients,and both in the upper ureteral and kidney for 29 patients.The diameter of the calculi ranged 0.6-2.0 cm,mean 1.33 cm.After ureter dilation and placement of ureteral access sheath,the stone were fragmented and removed with 200μm Ho ∶ YAG laser fiber,energy 0.8-1.0 J,frequency 5-10 Hz.Results The successful rate of stone fragmentation after single session was 92.86% (117/126).Mean operation time was 48 min(23-71 min).Six patients had low fever after the operation.Neither ureteral perforation nor pyonephrosis was observed.Conclusions The therapy of Holmium laser lithotriptor under flexible ureteroscope is safe and effective for upper urinary calculi,especially for upper ureteral,pelvis,middle calyx and upper calyx stones.%目的 探讨输尿管软镜下钬激光碎石术治疗上尿路结石的疗效.方法 上尿路结石患者126例,其中右侧结石75例,左侧结石51例.输尿管上段结石33例,输尿管上段合并肾结石29例,肾结石64例.结石大小0.6 ~2.0 cm,平均1.33 cm.经输尿管硬镜扩张后留置输尿管扩张鞘寻找结石,采用输尿管软镜下钬激光碎石术治疗,光纤直径200μm,能量0.8~1.0J,频率5~10Hz.结果 单次碎石成功117例(占92.86%),手术时间25~ 75 min,平均48 min.术后6例出现低热,无脓肾、输尿管穿孔等并发症.结论 输尿管软镜下钬激光碎石术治疗上尿路结石安全有效,尤其适用于输尿管上段、肾盂、肾中盏及肾上盏结石.

  19. 输尿管软镜在中晚期妊娠合并症状性结石16例中治疗体会%Through flexible ureteroscope in middle and late pregnancy complicated with symptomatic gallstone treatment experience 16 cases

    Institute of Scientific and Technical Information of China (English)

    范先明; 郭昭建; 林剑锋; 王世先; 涂建平; 叶振扬; 郑健忠; 梁福律

    2014-01-01

    目的 探讨输尿管软镜治疗中晚期妊娠合并症状性结石的可行性与临床疗效.方法 回顾性分析中晚期妊娠合并症状性结石16例患者的临床资料,所有患者均解痉、镇痛等保守治疗无效,采用输尿管软镜进行治疗.结果 10例一期成功碎石,3例术中发现为结石性脓肾,单纯放置D-J管引流,1例因结石较大,改行经皮肾穿刺造瘘术.术后症状消失,肾集合系统分离完全消失13例,3例好转.1例合并脓肾的患者再次出现严重感染,拔出D-J管,改行经皮肾穿刺造瘘持续引流.所有患者均足月分娩,无因操作而引起早产、脓毒血症、感染性休克等严重并发症.结论 输尿管软镜治疗中晚期妊娠合并症状性结石,临床效果较好、手术创伤较小,是一种安全、有效的方法.%Objective To explore through flexible ureteroscope in the treatment of middle and late pregnancy complicated with symptomatic gallstone feasibility and clinical efficacy.Methods Retrospectively analyzed the clinical data of middle and late pregnancy patients with symptoms of calculi:all patients were performed antispasmodic,analgesic and other conservative treatments,through flexible ureteroscope for treatment.Results Ten cases of success found in gravel,3 cases performed surgery for calculous pyonephrosis simply place the D-J tube drainage,1 case due to larger stones,but changed to percutaneous renal puncture and fistulation.Symptoms disappeared after surgery,13 cases of separation disappeared completely and 3 cases renal collecting system improved.One case of severe infection complicated with pyonephrosis appeared again,pull the D-J tube,but changed to percutaneous renal puncture nephrostomy drainage.All patients were term delivery and not due to operation resulting from prematurity,sepsis,septic shock and other serious complications.Conclusion Through flexible ureteroscope in the treatment of middle and late pregnancy complicated with symptomatic

  20. The Post-Ureteroscopic Lesion Scale (PULS)

    DEFF Research Database (Denmark)

    Schoenthaler, Martin; Buchholz, Noor; Farin, Erik

    2014-01-01

    The Post-Ureteroscopic Lesion Scale (PULS) offers a simple grading system for the description of ureteral lesions after ureteroscopy. In this article, we present the results of a video-based multicenter evaluation of the inter-rater reliability of clinically important PULS grades 0-3....

  1. New generation ventilators.

    Science.gov (United States)

    Bersten, A D; Skowronski, G A; Oh, T E

    1986-08-01

    Desirable features of new generation intensive care ventilators include the ability to ventilate a wide range of patient sizes, an uncomplicated control panel, an appropriate but not excessive variety of ventilatory patterns, adequate patient monitoring and alarm functions, and simplicity of cleaning and routine maintenance. Examples of currently available ventilators include the Servo 900-C, CPU-1, Engstrom Erica, Bear 5, Drager EV-A and Hamilton Veolar. The incorporation of microcomputer control into some of these ventilators has resulted in improved flexibility and a limited number of automatic responses to detected patient changes. However, the function of components provided to allow spontaneous ventilation, such as demand valves, requires considerable improvement. Current trends in ventilator design include further refinement of computer control and the provision of graphic displays showing the results of continuous sophisticated analysis of respiratory function. The extent to which these developments will prove clinically useful will require careful evaluation.

  2. Clinical efficacy of flexible ureteroscopic lithotripsy in the treatment of renal stones complicated with urinary tract infection%输尿管软镜治疗肾结石合并复杂尿路感染的疗效分析

    Institute of Scientific and Technical Information of China (English)

    徐明曦; 达骏; 张明; 董国勤; 卢慕峻; 姚海军; 张克; 王忠

    2015-01-01

    目的:评价输尿管软镜碎石取石术治疗肾结石伴难治性尿路感染的疗效和安全性。方法回顾分析2011年10月至2014年6月15例感染性肾结石应用输尿管软镜下钬激光碎石取石治疗的临床资料,与同期行输尿管软镜手术且无明显尿路感染患者进行对照。感染组15例患者术前均有尿路感染及发热症状,术前根据尿培养选用敏感抗生素治疗2周,尿中白细胞仍维持在100个/μL以上。手术使用Storz Flex‐X2 F7.5输尿管软镜进行碎石取石术,钬激光功率设置为0.8~1.0 J /5~10 Hz ,术中留置F6双J管。术后观察体温变化、血常规及KUB。术后2周复查尿常规及尿路CT 平扫,评估尿路感染控制情况及排石效果。术后2~4周拔除双J管。结果所有患者均一次碎石成功。术中发现感染组15例患者肾盂内尿液浑浊、伴有絮状物,其中有2例结石被脓苔样组织包裹。术中用钬激光碎石,用套石篮取出碎石,取净脓苔样组织,平均手术时间(30±21)(15~50) min ,术后结石清除率为93.3%(14/15);有2例(13.3%)出现术后发热,均在术后6 h内发生,最高体温在39℃以下,抗炎对症治疗后好转。结论敏感抗生素保护下行输尿管软镜碎石取石术是治疗感染性肾结石的安全有效的方法,其结石清除率高、并发症低,但术中需低压冲洗,且术后仍有出现发热的风险,需要密切关注。%ABSTRACT:Objective To study the efficacy and safety of flexible ureteroscopic lithotripsy for renal stones complicated with recurrent urinary tract infection (UTI) .Methods Clinical data of 15 patients with renal stones and recurrent UTI (UTI group) were retrospectively reviewed .The patients were treated with flexible ureteroscopic lithotripsy during Oct .2011 to June 2014 .A group of 15 patients with renal stones but without any sign of UTI were included as controls .All

  3. Ureteroscopic removal of forgotten ureteral stent

    Science.gov (United States)

    Kawahara, Takashi; Ishida, Hiroaki; Kubota, Yoshinobu; Matsuzaki, Junichi

    2012-01-01

    A 69-year-old female had a right ureteral stent placed due to ureteral stricture resulting from cervical cancer in March 2008. The ureteral stent migrated to the ureter and was not exchanged. A new ureteral stent was inserted, and was exchanged every 3 months. The patient was referred to our department to remove the forgotten ureteral stent. In January 2012, her old ureteral stent was removed ureteroscopically, and no ureteral stent encrustation was found. PMID:22707678

  4. Ureteroscopic skills with and without Roboflex Avicenna in the K-box(®) simulator.

    Science.gov (United States)

    Proietti, Silvia; Dragos, Laurian; Emiliani, Esteban; Butticè, Salvatore; Talso, Michele; Baghdadi, Mohammed; Villa, Luca; Doizi, Steeve; Giusti, Guido; Traxer, Olivier

    2017-01-01

    The aim of this study was to evaluate the acquisition of basic ureteroscopic skills with and without Roboflex Avicenna by subjects with no prior surgical training. Ten medical students were divided in two groups: Group 1 was trained with Roboflex Avicenna and Group 2 with flexible ureteroscope alone, using the K-box(®) simulator model. Participants were scored on their ability to perform or not two exercises, recording the time. In addition, the participants were evaluated on the quality of their performance for the following parameters: respect of the surrounding environment, flow of the operation, orientation, vision centering and stability. The first exercise was completed only by three and four out of five of students in Group 1 and Group 2, respectively. Stability with the scope was significantly more accurate in the first group compared with the second (P = 0.02). There were no differences in timing, flow or orientation between groups. Although not significant, a tendency of respecting the surrounding tissue and maintaining centered vision was perceived more in the first group. As for the second exercise, there were no differences between groups in regard of orientation, flow, respecting the surrounding tissue, stability or the ability of maintaining centered vision. Although not significant, the second group had a tendency of performing the exercise faster. According to these preliminary results, the acquisition of basic ureteroscopic skills with and without robotic fURS in the K-box(®) simulator, by subjects with no prior surgical training, is similar.

  5. Ureteroscopic management of chronic unilateral hematuria: a single-center experience over 22 years.

    Directory of Open Access Journals (Sweden)

    Motoo Araki

    Full Text Available OBJECTIVE: To analyze the short and long term safety and efficacy of ureteroscopic evaluation and management of chronic unilateral hematuria. METHODS: We retrospectively reviewed patients with chronic unilateral hematuria from 1987 to 2008. The distal to middle ureter was evaluated with a semi-rigid ureteroscope without a guidewire. Subsequently, the flexible ureteroscope was advanced into the upper ureter to the renal pelvis using a low-pressure automated irrigant system (Uromat™. Lesions identified ureteroscopically were treated with diathermy fulguration. RESULTS: One hundred and four (56 male, 48 female patients were identified, with a median age of 37 (14-80 years and median follow-up of 139 (34-277 months. The median preoperative duration of gross hematuria was 5 (1-144 months. Endoscopic findings included 61 (56% minute venous rupture (MVR; a venous bleeding without clear abnormalities, 21 (20% hemangioma (vascular tumor-like structure, 3 (3% varix (tortuous vein, 1 (1% calculus and 18 (17% no lesions. The incidence of "no lesions" was less in the recent 12 years (9% than the first 10 years (27%, while the incidence of MVR increased from 40 to 66% (p<0.05. All patients were treated endoscopically. Immediate success rate was 96% (100% in the recent 12 years. Long-term recurrent gross hematuria rate was 7%. Six resolved spontaneously and only 1 required ureteroscopy, revealing a different bleeding site. CONCLUSION: Ureteroscopy and diathermy fulguration is highly useful for evaluation and treatment of chronic unilateral hematuria. Sophisticated technique and improved instrumentation contributes to a better outcome.

  6. Clinical curative effect observation of "rule of three three" in the treatment for lower residual stones after flexible ureteroscope%“三三法则”促进输尿管软镜碎石术后残余结石排出的临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    王丹; 陈刚; 任洪艳

    2015-01-01

    Objective To observe and assess the effect about bundles of cure "Rule of three three" in the treatment for residual stones after Flexible Ureteroscope.Methods 120 patients with a single stone after urinary lithotripsy were divided into two groups according to the different indwelling time.Two cases of the control group were rejected because of severe hematuria.The control group (n=58) was subjected to the regular education (drinking water 3 000 ml per day with moderate exercise);The experiment group (n=60) was subjected to the "Rule of three three" (drinking 3 cups of water in thc morning、midday and night,with contralateral position 30 minutes,hot towel applying and gently tapping the kidney region 30 minutes).Results The calculi discharge rate and the net rate of experiment group [86.67% (52/60),55.00% (33/60)] were higher than the control group [53.45%(32/58),18.97%(11/58)] 14 days after surgery.The difference was statistically significant (P < 0.01).Further analysis showed that the discharge rate of residual stones in lower renal calyx in experiment group [86.67%(26/30)] was higher than the control group [32.14%(9/28)].The difference was statistically significant (P < 0.01).Conclusions The bundles of cure called "rule of three three" can improve the discharge rate of residual calculi after flexible ureteroscope and increase the discharge rate of residual stones in lower renal calyx significantly.%目的 观察集束化治疗方案“三三法则”在输尿管软镜碎石术后促进残余结石排出的效果.方法 选取泌尿系单一结石并行输尿管软镜碎石术后患者120例,按前后对照的方法分为2组.对照组60例,其中2例因严重血尿退出,最后实际入组58例,采用常规指导(饮水3 000 ml/d,适量运动);实验组60例,采用“三三法则”指导(每日早、中、晚3个时间段各饮水3杯,300 ml/杯,饮水后30 min健侧卧位30 min,同时热敷并轻叩患肾区30 min).记录2

  7. Combined electrohydraulic and holmium:YAG laser ureteroscopic nephrolithotripsy of large (greater than 4 cm) renal calculi.

    Science.gov (United States)

    Mariani, Albert J

    2007-01-01

    Percutaneous nephrolithotripsy is standard treatment for renal calculi larger than 2 cm. Modern flexible ureteroscopes and accessories using the complimentary effects of electrohydraulic lithotripsy and holmium:YAG laser lithotrites can treat large (greater than 4 cm) branched renal calculi in a minimally invasive fashion with similar or superior results. This report is an assessment of the safety and efficacy of ureteroscopic nephrolithotripsy monotherapy for the management of large (greater than 4 cm) branched renal calculi in the community setting. A total of 16 patients with 17 branched renal calculi ranging from 41 to 97 mm (mean 65) in length and 560 to 2,425 mm2 (mean 1,169) in area underwent staged ureteroscopic nephrolithotripsy monotherapy. Obesity (body mass index greater than 30) was present in 81% and 38% were morbidly obese (body mass index greater than 40). An infectious etiology was present in 81% and hard stone components were present in 94%. All patients presented with hematuria, pain and/or recurrent urinary tract infection. Lithotripsy was performed with a single deflection flexible ureteroscope and predominantly electrohydraulic lithotripsy. Laser drilling was used (in 4) to weaken hard stones before electrohydraulic lithotripsy. Low intrarenal pressure was maintained by continuous bladder drainage and placement of a stiff safety wire. Visibility was maintained using manual pulsatile irrigation. All patients were rendered pain and infection-free. No patient required a blood transfusion and there was no change in serum creatinine. Mobile stone-free status was achieved in 15 of 17 renal units (88%) with a mean of 2.4 stages and 36 of 40 (90%) procedures performed on an outpatient basis. Operative time averaged 49 minutes per stage and 115 minutes per calculus. There were 3 patients admitted for fever and 1 patient (90 years old) admitted for pneumonia 3 days postoperatively. There were also 3 patients with calculi larger than 75 mm who required

  8. Withdraw of the Ureteroscope Causes Fragmented Ureter Stones to Disperse

    Directory of Open Access Journals (Sweden)

    Onder Canguven

    2013-09-01

    Full Text Available Introduction Ureteroscopy has improved from the first use of ureteroscope in the 1970's. Although the success rate increased in the last years, (1 new treatment techniques are being developed for impacted and large proximal ureter stones (2. Pneumatic lithotripsy has high efficiency with low complication rates (2. However, in case of steinstrasse and large (> 1 cm ureter stones, fragmented small stones may obstruct insertion of a ureteroscope after initial lithotripsy. In order to triumph over this issue, multiple ureteroscopic passages and manipulations needed for extraction of these small stones by forceps or basket catheters. The overall incidence of stricture was found upto 14.2% when the fragments were removed with a grasping forceps or a basket (3. We present our technique to disperse small fragmented stones in order to contact non-fragmented rest stone. Materials and Methods Ureteral lithotripsy was performed with an 8-9.8F semirigid ureteroscope using a pneumatic lithotripter (Swiss LithoClast, EMS, Nyon, Switzerland. The stone was fragmented into small pieces as small as 2-3 mm. by pneumatic lithotripter. Eventually, these fragmented stones interfered with vision and the lithotripter to get in touch with the rest stone. After fragmenting distal part of the large stone, the ureteroscope was pulled back out of ureter. While pulling back, the operating channel was closed and irrigation fluid was flowing in order not to decrease pressure behind the stones. Simultaneously, a person tilted the operating table to about 30° in reverse Trendelenburg position. When the ureteroscope was out of ureteral orifice, the operating channel was opened and irrigation fluid was stopped. This maneuver aided decreasing pressure in the bladder more rapidly in addition to feeding tube. Stone dust and antegrade fluid flow were easily seen out of the ureteral orifice. Ureteroscope was re-inserted after 30-60 seconds. While reaching the rest of the stone, small

  9. A NEW GENERATION - QUALITY DESIGNER

    Directory of Open Access Journals (Sweden)

    GRATIELA DANA BOCA

    2010-07-01

    Full Text Available Now more then ever the quality management need some changes, not because of generation changes but because of the new provocation ‘’ green products’’. The ‘’green products’’ provocation needs changes to be implemented in each manufacturing technology and also in quality management. The organization must to be flexible to costumers needs and also to the new trends in industrial fields. This new generation for quality management change appear as a result of new eco-age , when in every second a new method, a new discover in researching work will bring more and new solutions to similar problem but in different places. The paper present the investigation results in a common manufacture organization who produce industrial products and also the solutions propose by author to improve the quality products and organization quality management.

  10. Effect of alpha1-blockers on stentless ureteroscopic lithotripsy

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    Jianguo Zhu

    2016-02-01

    Full Text Available ABSTRACT Objective To evaluate the clinical efficiency of alpha1-adrenergic antagonists on stentless ureteroscopic lithotripsy treating uncomplicated lower ureteral stones. Materials and Methods From January 2007 to January 2013, 84 patients who have uncomplicated lower ureteral stones treated by ureteroscopic intracorporeal lithotripsy with the holmium laser were analyzed. The patients were divided into two groups, group A (44 patients received indwelled double-J stents and group B (40 patients were treated by alpha1-adrenergic antagonists without stents. All cases of group B were treated with alpha1 blocker for 1 week. Results The mean operative time of group A was significantly longer than group B. The incidences of hematuria, flank/abdominal pain, frequency/urgency after surgery were statistically different between both groups. The stone-free rate of each group was 100%. Conclusions The effect of alpha1-adrenergic antagonists is more significant than indwelling stent after ureteroscopic lithotripsy in treating uncomplicated lower ureteral stones.

  11. Miniature ureteroscope tip designs for use in thulium fiber laser lithotripsy

    Science.gov (United States)

    Kennedy, Joshua D.; Wilson, Christopher R.; Irby, Pierce B.; Fried, Nathaniel M.

    2017-02-01

    A miniature ureteroscope has the potential to eliminate need for full anesthesia and dilation, increase comfort and safety of laser lithotripsy via ureteroscopy, and reduce hospital costs via an office based procedure. A prototype, 4.5 Fr (1.5-mm-OD), five channel ureteroscope tip was developed, housing a 200-μm-ID central channel for insertion of small, 100-μm-core fibers and four surrounding channels, each with 510-μm-ID for instrumentation, irrigation, imaging, and illumination, respectively. Common urological instruments (including fibers, guidewires, and stone baskets) were inserted through tip's working channels to demonstrate feasibility. Low irrigation rates were measured, revealing a need for manual pump-assisted irrigation. Imaging was conducted using 3k, 6k, and 10k pixel miniature flexible endoscopes with 0.4, 0.6, and 0.9 mm outer diameters, respectively. The 3k pixel endoscope with integrated illumination was inserted through the prototype unimpeded, and successfully demonstrated ability to differentiate between hard tissues (e.g. kidney stones) and soft tissues (e.g. ureter wall), for visibility and safety during potential clinical application. Based on both image quality and instrument diameter, the 6k pixel endoscope provided an optimal solution for miniature ureteroscopy.

  12. Extraction of trapped double J in ureteroscope: a novel technique.

    Science.gov (United States)

    Akhavizadegan, Hamed

    2017-08-07

    Urological endoscopes and percutaneous devices are expensive and their maintenance and cleaning need special attention. Sometimes urologists can help repairing their devices. During taking out a Double J, Double J was trapped in the working channel of ureteroscope unintentionally. It was not possible to take it out by pushing methods. Finally, Double J was pulled out by a changed nephrostomy needle to a small curve hook. Using the hand-made hook to pull out a trapped Double J from ureteroscope does not destroy the device.

  13. Efficacy and safety of flexible ureteroscope lithotripsy and percutaneous nephro-lithotomy lithotripsy for renal calculus <2 cm:a Meta-analysis%输尿管软镜碎石术与经皮肾镜取石术治疗直径<2 cm肾结石的有效性和安全性的 Met a分析

    Institute of Scientific and Technical Information of China (English)

    张克; 张雁钢; 王靖宇; 任瑞民

    2015-01-01

    目的:系统评价输尿管软镜碎石术与经皮肾镜取石术在治疗肾结石(直径<2 cm )方面的有效性和安全性。方法计算机检索Pubmed、ScienceDirect、Ovid、Springer、Wiley Online Library、The Cochrane Library、CNKI、CBM、VIP及万方数据库,全面收集有关输尿管软镜碎石术和经皮肾镜取石术比较治疗肾结石的临床对照试验。由2位研究者独立进行文献筛选、资料提取和评价纳入研究的方法学质量,采用RevMan 5.2软件进行 Meta分析。结果纳入11篇研究,共计1060例患者。 Meta分析结果显示:输尿管软镜碎石术的清石率低于经皮肾镜取石术[OR=0.44,95% CI(0.29~0.67),P=0.0001],而在术中出血[MD=-72.78,95% CI(-80.77~-64.79),P<0.00001]、平均血红蛋白下降量[MD=-0.90,95% CI(-1.41~0.40),P=0.0005]、是否输血[OR=0.07,95% CI(0.02~0.27),P=0.0002]等方面则优于经皮肾镜碎石术。结论在结石清除率方面,输尿管软镜取石术低于经皮肾镜取石术,而在手术时间、术中出血量、是否输血等方面,输尿管软镜碎石术则优于经皮肾镜取石术。%Objective To evaluate the efficacy and safety of flexible ureteroscope lithotripsy (FURS) and percutaneous nephrolithotomy lithotripsy (PCNL) for patients with renal calculus (diameter <2 cm) .Methods Controlled clinical trials on FURS and PCNL for the treatment of kidney stones were searched in Pubmed ,ScienceDirect ,Ovid ,Springer ,Wiley Online Library ,Cochrane Library ,CNKI ,CBM ,VIP and Wanfang Database .Data collected were screened ,extracted and evaluated by two independent researchers .And then a Meta‐analysis was performed using RevMan 5 .2 software .Results A total of 11 studies were included ,and 1 060 cases were involved .Meta‐analysis showed that PCNL was better than FURS in stone clear‐ance rate [OR= 0 .44 ,95% CI (0

  14. Flexibility.

    Science.gov (United States)

    Humphrey, L. Dennis

    1981-01-01

    Flexibility is an important aspect of all sports and recreational activities. Flexibility can be developed and maintained by stretching exercises. Exercises designed to develop flexibility in ankle joints, knees, hips, and the lower back are presented. (JN)

  15. Clinical factors associated with postoperative hydronephrosis after ureteroscopic lithotripsy

    Science.gov (United States)

    Kim, Sun Woo; Ahn, Ji Hoon; Yim, Sang Un; Cho, Yang Hyun; Shin, Bo Sung; Chung, Ho Seok; Yu, Ho Song; Oh, Kyung Jin; Kim, Sun-Ouck; Jung, Seung Il; Kang, Taek Won; Kwon, Dong Deuk; Park, Kwangsung

    2016-01-01

    Purpose This study aimed to determine the predictors of ipsilateral hydronephrosis after ureteroscopic lithotripsy for ureteral calculi. Materials and Methods From January 2010 to December 2014, a total of 204 patients with ureteral calculi who underwent ureteroscopic lithotripsy were reviewed. Patients with lack of clinical data, presence of ureteral rupture, and who underwent simultaneous percutaneous nephrolithotomy (PNL) were excluded. Postoperative hydronephrosis was determined via computed tomographic scan or renal ultrasonography, at 6 months after ureteroscopic lithotripsy. Multivariable analysis was performed to determine clinical factors associated with ipsilateral hydronephrosis. Results A total of 137 patients were enrolled in this study. The mean age of the patients was 58.8±14.2 years and the mean stone size was 10.0±4.6 mm. The stone-free rate was 85.4%. Overall, 44 of the 137 patients (32.1%) had postoperative hydronephrosis. Significant differences between the hydronephrosis and nonhydronephrosis groups were noted in terms of stone location, preoperative hydronephrosis, impacted stone, operation time, and ureteral stent duration (all, p<0.05). On multivariable analysis, increasing preoperative diameter of the hydronephrotic kidney (adjusted odds ratio [OR], 1.21; 95% confidence interval [CI], 1.12–1.31; p=0.001) and impacted stone (adjusted OR, 3.01; 95% CI, 1.15–7.61; p=0.031) independently predicted the occurrence of postoperative hydronpehrosis. Conclusions Large preoperative diameter of the hydronephrotic kidney and presence of impacted stones were associated with hydronephrosis after ureteroscopic stone removal. Therefore, patients with these predictive factors undergo more intensive imaging follow-up in order to prevent renal deterioration due to postoperative hydronephrosis. PMID:27617316

  16. The Application of Pediatric Ureteroscope for Seminal Vesiculoscopy

    Directory of Open Access Journals (Sweden)

    Shulin Guo

    2015-01-01

    Full Text Available To describe a novel technique of transurethral seminal vesiculoscopy using a pediatric ureteroscope in the diagnosis and management of persistent hematospermia, a retrospective study was carried out for 20 patients with recurrent hematospermia whom we evaluated and treated using a 6–7.5F (6F front end and 7.5F rear end pediatric ureteroscope from August 2009 to September 2013. For the 20 patients, the age ranges from 25 to 48 years with a mean age of 36 years. The duration of the hematospermia ranges from 6 to 48 months with a mean duration of 18 months. Transurethral seminal vesiculoscopy was successfully performed in the 20 cases and the mean operative time was 35 min (ranges from 25 to 90 min. Among the 20 patients, 11 patients were found to have seminal vesiculitis, five were with seminal vesicle stone, one was with prostatic utricle stone, one was with prostate cyst, and one was with ejaculatory duct obstruction. The mean follow-up period was 7 months (ranged from 6 to 12 months. Hematospermia in 19 cases disappeared after the surgery and only in one patient the hematospermia recurred 6 months after the surgery. The cure rate was 95%. This study indicated that transurethral seminal vesiculoscopy could be performed easily using a semirigid pediatric ureteroscope with few complications and is an effective therapeutic approach for persistent hematospermia.

  17. Acupoint Massage in Relieving Pain after Ureteroscopic Holmium Laser Lithotripsy

    Institute of Scientific and Technical Information of China (English)

    Xia Wei-qin

    2014-01-01

    Objective: To observe the effect of acupoint massage in relieving pain after ureteroscopic holmium laser lithotripsy. Methods: Ninety-two patients undergone ureteroscopic holmium laser lithotripsy were enrolled and randomized into a treatment group and a control group, 46 in each group. Patients in the control group were given regular nursing care, while patients in the treatment group were intervened by acupoint massage in addition to the regular nursing care. The pain was evaluated by visual analogue scale (VAS) at 6 h, 12 h, and 24 h after operation, and compared between the two groups. Results:There was no significant difference in comparing the VAS score at 6 h after operation between the two groups (P>0.05). The VAS scores in the treatment group at 12 h and 24 h after operation were significantly lower than those in the control group (both P Conclusion: Acupoint massage can effectively relieve the pain after ureteroscopic holmium laser lithotripsy, reduce the use of analgesics, and promote the recovery.

  18. Efficacy and safety of retrograde flexible ureteroscopic lithotripsy with holmium:YAG laser in the treatment of renal stones%逆行软性输尿管镜下钬激光碎石术治疗肾结石的有效性与安全性分析

    Institute of Scientific and Technical Information of China (English)

    曾国华; 李佳胜; 赵志健; 刘陈黎; 刘旸; 曾滔; 刘永达; 陈文忠; 吴文起

    2015-01-01

    Objective To evaluate the efficacy and safety of retrograde flexible ureteroscopic lithotripsy ( RFUL) with holmium:YAG laser for the treatment of renal stones with a large series.Methods The data of 466 patients who underwent RFUL with holmium:YAG laser for the treatment of kidney stones between January 2013 and December 2013 were collected.The maximum diameter of stone was 23 ±16 mm.The stone free rate, complications, retreatment rate were evaluated.Results Out of the 466 patients, the mean operative time and postoperative hospital stay were 33.5 ±18.8 min and 2.3 ±2.0 d.The stone free rate was 67.6% ( 315/466 ) after single procedure, which increased to 69.5% ( 324/466 ) via re-treatments after 3 months.The retreatment rate was 4.3%(20/466), with a total of 493 RFUL procedures performed and 1.06 times per patient.There were 67 (14.4%) cases undergoing complications.Five cases had false passage of ureter orifice causing slight ureteral wall injuries.Steinstrasse occurred in 9 cases, ureteral perforation in 3 cases and perirenal hematoma in 1 case.Overall postoperative fever rate was 10.7%(50/466) with urosepsis in 16 cases (3.4%).When the stone size was≤10, 11-20, 21-30, 31-40, and >40 mm, the stone free rates after a single procedure were 97.0% ( 65/67 ) , 84.2% ( 160/190 ) , 63.1%(70/111), 29.2%(14/48), 12.0%(6/50) (P<0.001), and the postoperative fever rates were 1.5%(1/67), 9.5%(18/190), 13.5% (15/111), 14.6% (7/48), 18.0% (9/50), respectively. The postoperative fever rates were 19.3%(27/140) and 7.1%(23/326) (P<0.001) in the patient with positive and negative preoperative urine leukocyte, and 22.0% ( 22/100 ) and 7.7% ( 28/366 ) ( P <0.001) in patients with positive and negative preoperative urine culture.Conclusions RFUL with holmium:YAG laser is a safe and effective treatment for kidney stones.The postoperative fever rate would increase and stone free rate would reduce with the increased stone size.%目的:评价逆行软性输尿管镜下钬激

  19. Design of Flexible Benefits System for New Generation of Knowledge--Based Staff in the View of Maslow’s Hierarchy of Needs%马斯洛需要理论视角下知识型新生代员工弹性福利体系设计--以CI公司为例

    Institute of Scientific and Technical Information of China (English)

    伍辉延; 雷霞飞

    2015-01-01

    从马斯洛需要层次理论视角出发,基于知识型新生代员工的特征,结合知识型新生代员工福利管理中存在的问题及其福利需要,分析弹性福利制与知识型新生代员工福利需要的整合与优化,并以CI公司为例试图构建适合于知识型新生代员工的弹性福利体系。%Starting from Maslow’s Hierarchy of Needs, based on the characteristics of the new generation of knowl⁃edge-based staff, and combining the existing problems in welfare management of the new generation of knowl⁃edge-based staff&their welfare needs, the flexible benefits system and the integration&optimization of their welfare needs have been analyzed. The paper also makes an attempt to establish a flexible benefits system suitable for the new generation of knowledge-based staff by taking CI Company as an example.

  20. Rigid ureteroscopic lithotripsy versus percutaneous nephrolithotomy for large proximal ureteral stones: A meta-analysis

    Science.gov (United States)

    Hu, Henglong; Lu, Yuchao; Zhang, Jiaqiao; Qin, Baolong; Wang, Yufeng; Zhang, Zongbiao

    2017-01-01

    Object To compare the safety and efficacy of rigid ureteroscopic lithotripsy (rigid URSL) and percutaneous nephrolithotomy (PCNL) in treating large proximal ureteral stones. Methods A systematic search of PubMed, EMBASE, Cochrane Library, and Web of Science databases was performed to find out relevant studies. After literature screening according to the predetermined inclusion and exclusion criteria, data of eligible studies was extracted and then a meta-analysis was conducted via RevMan 5.3 software. Results Five randomized controlled trials (RCTs), one prospective and four retrospective cohort studies involving 837 patients were included. Patients underwent rigid URSL were associated with shorter operation time (WMD, -23.66min; 95%CI, −45.00 to -2.32; p = 0.03), shorter hospital stay (WMD, -2.76d; 95%CI, −3.51 to −2.02; phematuria (RR, 0.38; 95%CI, 0.25 to 0.57; p < 0.0001). No significant difference was observed in terms of incidence of embolization, pain and ureterostenosis. When cohort studies or studies in which flexible ureteroscopy was used as an intraoperative auxiliary procedure were excluded, we both found that most of the results kept stable. Conclusions Both PCNL and rigid URSL are safe for patients with large proximal ureteral stones while PCNL is more effective in stone clearance. PMID:28182718

  1. New generation of space TWTAs

    Science.gov (United States)

    Lewis, G. C.; Sosa, E. N.

    1992-03-01

    A new generation of space qualified traveling wave tube amplifiers has been developed and is ready for system application. This new generation of hardware satisfies the system designer's desire for higher efficiency, lighter weight and smaller size hardware at no degradation of life, reliability and performance. Recent developments in TWTA technology is available for both regulated and unregulated bus spacecraft. EPC efficiencies in excess of 95 percent and TWT efficiencies above 60 percent are a reality. Weight reductions are achieved with new packaging techniques. Additionally, single (one TWT/one EPC) and dual (two TWT's/one EPC) TWTA trade-offs are discussed for system consideration. Finally, currently available options such as linearization and automatic restart capability are presented.

  2. Pre-Emptive Tramadol Could Reduce Pain after Ureteroscopic Lithotripsy

    Science.gov (United States)

    Denčić, Nataša; Jovičić, Jelena; Mirković, Jelena; Durutović, Otaš; Milenković-Petronić, Dragica; Lađević, Nebojša

    2014-01-01

    Purpose Optimal analgesia in ambulatory urology patients still remains a challenge. The aim of this study was to examine if the pre-emptive use of intravenous tramadol can reduce pain after ureteroscopic lithotripsy in patients diagnosed with unilateral ureteral stones. Materials and Methods This prospective pilot cohort study included 74 patients diagnosed with unilateral ureteral stones who underwent ureteroscopic lithotripsy under general anesthesia in the Urology Clinic at the Clinical Center of Serbia from March to June 2012. All patients were randomly allocated to two groups: one group (38 patients) received intravenous infusion of tramadol 100 mg in 500 mL 0.9%NaCl one hour before the procedure, while the other group (36 patients) received 500 mL 0.9%NaCl at the same time. Visual analogue scale (VAS) scores were recorded once prior to surgery and two times after the surgery (1 h and 6 h, respectively). The patients were prescribed additional postoperative analgesia (diclofenac 75 mg i.m.) when required. Pre-emptive effects of tramadol were assessed measuring pain scores, VAS1 and VAS2, intraoperative fentanyl consumption, and postoperative analgesic requirement. Results The average VAS1 score in the tramadol group was significantly lower than that in the non-tramadol group. The difference in average VAS2 score values between the two groups was not statistically significant; however, there were more patients who experienced severe pain in the non-tramadol group (ptramadol did reduce early postoperative pain. The patients who received pre-emptive tramadol were less likely to experience severe post-operative pain. PMID:25048508

  3. Drospirinone: new generation of progestogen

    Directory of Open Access Journals (Sweden)

    Ali Baziad

    2005-09-01

    Full Text Available Drospirinone is a new generation of progestogen that possesses antimineralocorticoid effect. Progestogen of this type has been used as a component in combined contraceptives. The combined contraceptives of old generation contained progestogen component of testosterone derivative. Progestogen of this type does not have antimineralcorticoid effect, such that it could cause fluid retention. As a result, women who used combined pills of this type often complained of headache, breast pain, calf pain, increased body weight and blood pressure. Owing to its androgenic effect, combined contraception pills that contained testosterone-derived progestogen may cause acne and oily face. Combined contraception that contains drospirinone does not cause headache, breast pain, calf pain, increased body weight and blood pressure. Drospirinone has such a strong anti-androgenic nature that it does not result in acne and oily face. In addition, combination of ethinylestradiol and drospirinone can be used for treating pre-menstrual syndrome and menstrual pain. Drospirinone does not affect lipid and carbohydrate metabolism. (Med J Indones 2005; 14: 190-3Keywords: drospirinone, oral contraceptive

  4. A new Generation of Standard Solar Models

    CERN Document Server

    Vinyoles, Núria; Villante, Francesco L; Basu, Sarbani; Bergström, Johannes; Gonzalez-Garcia, M C; Maltoni, Michele; Peña-Garay, Carlos; Song, Ningqiang

    2016-01-01

    We compute a new generation of standard solar models (SSMs) that includes recent updates on some important nuclear reaction rates and a more consistent treatment of the equation of state. Models also include a novel and flexible treatment of opacity uncertainties based on opacity kernels, required in the light of recent theoretical and experimental works on radiative opacity. Two large sets of SSMs, each based on a different canonical set of solar abundances with high and low metallicity (Z), are computed to determine model uncertainties and correlations among different observables. We present detailed comparisons of high- and low-Z models against different ensembles of solar observables including solar neutrinos, surface helium abundance, depth of convective envelope and sound speed profile. A global comparison, including all observables, yields a p-value of 2.7$\\sigma$ for the high-Z model and 4.7$\\sigma$ for the low-Z one. When the sound-speed differences in the narrow region of $0.65 < r/R_{sun} < 0...

  5. Treatment of Special Renal Colic with Ureteroscope and Holmium YAG Laser

    Institute of Scientific and Technical Information of China (English)

    沈明顺; 刘军

    2002-01-01

    Objective To investigate the method of emergent relief of special renal colicand treatment of ureter diseases causing renal colic. Methods By analyzing 63 cases of special re-nal colic treated with ureteroscope and Holmium YAG laser. Results 61 cases of renal colic were re-lieved in a short period of time and the ariginal ureter diseases causing renal colic were cured. Conclu-sion Special renal colic could be treated with ureteroscope and Holmium YAG laser in a quick and ef-fective manner.

  6. A New Generation of Standard Solar Models

    Science.gov (United States)

    Vinyoles, Núria; Serenelli, Aldo M.; Villante, Francesco L.; Basu, Sarbani; Bergström, Johannes; Gonzalez-Garcia, M. C.; Maltoni, Michele; Peña-Garay, Carlos; Song, Ningqiang

    2017-02-01

    We compute a new generation of standard solar models (SSMs) that includes recent updates on some important nuclear reaction rates and a more consistent treatment of the equation of state. Models also include a novel and flexible treatment of opacity uncertainties based on opacity kernels, required in light of recent theoretical and experimental works on radiative opacity. Two large sets of SSMs, each based on a different canonical set of solar abundances with high and low metallicity (Z), are computed to determine model uncertainties and correlations among different observables. We present detailed comparisons of high- and low-Z models against different ensembles of solar observables, including solar neutrinos, surface helium abundance, depth of the convective envelope, and sound speed profile. A global comparison, including all observables, yields a p-value of 2.7σ for the high-Z model and 4.7σ for the low-Z one. When the sound speed differences in the narrow region of 0.65< r/{R}ȯ < 0.70 are excluded from the analysis, results are 0.9σ and 3.0σ for high- and low-Z models respectively. These results show that high-Z models agree well with solar data but have a systematic problem right below the bottom of the convective envelope linked to steepness of molecular weight and temperature gradients, and that low-Z models lead to a much more general disagreement with solar data. We also show that, while simple parametrizations of opacity uncertainties can strongly alleviate the solar abundance problem, they are insufficient to substantially improve the agreement of SSMs with helioseismic data beyond that obtained for high-Z models due to the intrinsic correlations of theoretical predictions.

  7. A new generation of current inverters; Wechselrichter im Generationswechsel

    Energy Technology Data Exchange (ETDEWEB)

    Seltmann, T.

    2002-03-05

    The new generation of current inverters is coming. There is a trend towards 'multi-string' systems, often with large input voltages. The new systems have higher flexibility in constructing modular systems and also in connecting CIS and CdTe modules. [German] Die naechste Generation der Netzeinspeisegeraete nimmt Konturen an. Der Trend geht zu 'Multi-String'. Mehrere Hersteller setzen die Idee auf verschiedene Weise um. Ausserdem faellt auf, dass bei vielen neuen Geraeten der Eingangsspannungsbereich sehr grosszuegig ausgelegt ist. Vorteile bietet das nicht nur fuer die Flexibilitaet bei der Modulverschaltung, sondern auch beim Anschluss von CIS- und CdTe-Modulen. (orig.)

  8. Extraction of a long-forgotten ureteral stent by ureteroscopic pneumatic lithotripsy

    Institute of Scientific and Technical Information of China (English)

    江军; 朱方强; 姜庆; 王洛夫

    2004-01-01

    @@ A long-forgotten ureteral stent is occasionally encountered in urological practice. It can be complicated by encrustation and may pose a management and legal dilemma. Here, we report on a long-forgotten ureteral stent that had completely calcified after 30 months in a patient with chronic renal insufficiency due to obstructive uropathy. The stent was extracted successfully by means of ureteroscopic pneumatic lithotripsy.

  9. Advertising of a new generation – today!

    Directory of Open Access Journals (Sweden)

    Andrei Maier

    2015-10-01

    Full Text Available The paper deals with the type of Internet advertising “The Banner of sales” and the system of advertisement of a new generation (ANG. The peculiar features of “The banner of sales” program and the system ANG have been analyzed; their features and benefits in comparison with other types of Internet advertising have been elicited. The undertaken survey has demonstrated that the “The Banner of sales” may rightfully exist in the Internet.

  10. New generation of the multimedia search engines

    Science.gov (United States)

    Mijes Cruz, Mario Humberto; Soto Aldaco, Andrea; Maldonado Cano, Luis Alejandro; López Rodríguez, Mario; Rodríguez Vázqueza, Manuel Antonio; Amaya Reyes, Laura Mariel; Cano Martínez, Elizabeth; Pérez Rosas, Osvaldo Gerardo; Rodríguez Espejo, Luis; Flores Secundino, Jesús Abimelek; Rivera Martínez, José Luis; García Vázquez, Mireya Saraí; Zamudio Fuentes, Luis Miguel; Sánchez Valenzuela, Juan Carlos; Montoya Obeso, Abraham; Ramírez Acosta, Alejandro Álvaro

    2016-09-01

    Current search engines are based upon search methods that involve the combination of words (text-based search); which has been efficient until now. However, the Internet's growing demand indicates that there's more diversity on it with each passing day. Text-based searches are becoming limited, as most of the information on the Internet can be found in different types of content denominated multimedia content (images, audio files, video files). Indeed, what needs to be improved in current search engines is: search content, and precision; as well as an accurate display of expected search results by the user. Any search can be more precise if it uses more text parameters, but it doesn't help improve the content or speed of the search itself. One solution is to improve them through the characterization of the content for the search in multimedia files. In this article, an analysis of the new generation multimedia search engines is presented, focusing the needs according to new technologies. Multimedia content has become a central part of the flow of information in our daily life. This reflects the necessity of having multimedia search engines, as well as knowing the real tasks that it must comply. Through this analysis, it is shown that there are not many search engines that can perform content searches. The area of research of multimedia search engines of new generation is a multidisciplinary area that's in constant growth, generating tools that satisfy the different needs of new generation systems.

  11. Application of Ureteroscope in Emergency Treatment with Persistent Renal Colic Patients during Pregnancy.

    Directory of Open Access Journals (Sweden)

    Shilin Zhang

    Full Text Available Although the application of ureteroscopy in the treatment of ureteral calculi during pregnancy has been on the rise, for persistent renal colic patients without ultrasound-detected ureteral calculi, it may represent a clinical dilemma due to the potential risks for both mother and fetus.The aim of the present study is to present our experience with the application of the ureteroscope in the emergency treatment of persistent renal colic patients during pregnancy.From March 2009 to September 2014, a total of 117 pregnant women who received ureteroscopy for persistent renal colic were retrospectively analyzed. Patients were divided into three groups according to duration of the persistent renal colic: Group A (within 12 hours; 24 cases; Group B (12 to 24 hours; 76 cases; and Group C (more than 24 hours; 17 cases. The stone-free rate, complications, and other qualitative data were analyzed.Of the 117 patients, 31 patients who were found not to have renal or ureteral calculi received ureteroscopic double-J (DJ stent insertion, whereas 86 patients who were found with ureteral calculi received ureteroscopic lithotripsy (URSL and DJ stent insertion. Among them, 24 patients (27.9% were found with ureteral calculi by ureteroscopy rather than ultrasound. In addition, 73 patients (84.9% had complete fragmentation of calculi; 12 patients (10.3% had a threatened abortion (the rates of threatened abortion in Groups A, B and C were 8.3% vs. 6.5% vs. 29.4%; Group C compared with Groups A and B, p<0.05, and one patient (1.2% had urosepsis (in Group C. However, these complications were cured with conservative treatment, without postpartum infant and maternal complications.For pregnant patients with persistent renal colic/ureteral calculi and hydronephrosis, ureteroscopic DJ stent insertion and URSL are effective and safe options when conservative treatment fails, even if no urinary calculi were found by ultrasound. At the same time, for patients with persistent

  12. Modelling of new generation plasma optical devices

    Directory of Open Access Journals (Sweden)

    Litovko Irina V.

    2016-06-01

    Full Text Available The paper presents new generation plasma optical devices based on the electrostatic plasma lens configuration that opens a novel attractive possibility for effective high-tech practical applications. Original approaches to use of plasma accelerators with closed electron drift and open walls for the creation of a cost-effective low-maintenance plasma lens with positive space charge and possible application for low-cost, low-energy rocket engine are described. The preliminary experimental, theoretical and simulation results are presented. It is noted that the presented plasma devices are attractive for many different applications in the state-of-the-art vacuum-plasma processing.

  13. New generation concretes including reactive powder concretes

    Directory of Open Access Journals (Sweden)

    Stefania Grzeszczyk

    2015-09-01

    Full Text Available Based on a broad literature review, this paper presents characteristics of new generation composites on the basis of cements which are applied in engineering structures and in rehabilitation of structures. The role of cement, microfillers, superplasticizers and fibers in the above stated composites i.e. factors which allow for the maximum packing of particles in the cement matrix and a minimum pore volume, and the increase in composite bending strength, have been discussed. Special attention was paid to Reactive Powder Concrete in which coarse aggregate was replaced by ground quartz and sand. Such composites contain active microfillers and the applied new-generation superplasticizers allow us to decrease the water-cement ratio in the composite up to 0.2. Whereas, steel fibre additive allows us to significantly improve the bending strength.The paper presents the properties of the excellent Ductal — a composite from Reactive Powder Concrete, which at compressive strength from 180 to 230 MPa achieves the tensile strength of 30 to 50 MPa. Its application allows us to create slim profiles and tall light and slender, and simultaneously durable and corrosion-resistant structural elements of considerable span. This paper gives a few examples of Ductal application in practice.[b]Keywords[/b]: civil engineering, composite materials, reactive powder concrete

  14. [Ureterorenoscopy (URS) in treatment of ureteral calculi. II. Ureteroscopic treatment of calculus debris after ESWL].

    Science.gov (United States)

    Fernandez De la Maza, S; Noldus, J; Huland, H

    1999-03-01

    We were interested in the efficacy and morbidity of the ureteroscopy (URS) in the treatment of "steinstrasse" after ESWL. From 1991 to 1996, 27 patients with "steinstrasse" were treated with a total of 32 ureteroscopic procedures. The URS alone had a stonefree success rate of 43.7% (n = 14). URS combined with ESWL was effective in 43.7% (n = 14), leading to an overall success rate of 87.4%. In 4 cases (12.6%) a second therapy was necessary (in 3 cases a second URS + ESWL and in one patient a nephrectomy due to septic pyonephrosis. The overall rate of auxiliary ESWL after URS was 53.1%. Mean operating time was 72 minutes (20-180 min). The rate of complications was 21.8% (n = 7) and mainly due to ureteral perforations or postoperative fever but none suffered from late complications like ureteral stricture. All treated patients received a double-J-stent and antibiotics. The treatment of "steinstrasse" in the middle portion of the ureter proved to be more difficult due to the anatomical position of the ureter and lasted in a longer operating time as the upper or distal "steinstrasse". The stone extraction and the lithoclast-lithotripsy alone or in combination were the most frequent used ureteroscopic procedures to eliminate stone fragments. The URS alone or in combination with the ESWL for the treatment of "steinstrasse" is a highly effective and safe approach.

  15. BCM6: New Generation of Boron Meter

    Energy Technology Data Exchange (ETDEWEB)

    Pirat, P. [Rolls-Royce Civil Nuclear SAS (France)

    2010-07-01

    Full text of publication follows: Rolls-Royce has developed a new generation of boron meter, based on more than 30 years of experience. The Rolls-Royce BCM6 boron meter provides Nuclear Power Plant (NPP) operators with the boron concentration of the primary circuit. The meter provides continuous and safe measurements with no manual sampling and no human contact. In this paper, technical features, advantages and customer benefits of the use of the new generation of Rolls-Royce BCM6 boron meter will be detailed. Values and associated alarms are provides over different media: 4-20 mA outputs, relays, displays in the main control room and in the chemical lab, and digital links. A special alarm avoids unexpected homogeneous dilution of the primary circuit, which is a critical operational parameter. The Rolls-Royce BCM6 boron meter is fully configurable over a set of parameters allowing adaptation to customer needs. It has a differential capability, thus eliminating neutronic noise and keeping measurements accurate, even in the case of fuel clad rupture. Measurements are accurate, reliable, and have a quick response time. Equipment meets state-of-the-art qualification requests. Designed in 2008, the BCM6 boron meter is the newest equipment of Rolls-Royce boron meters product line. It has been chosen to equip the French EPR NPP and complies with the state-of-the-art of the technology. Rolls-Royce has more than 30 years of experience in Instrumentation and Controls with more than 75 NPP units operating worldwide. All of this experience return has been put in this new generation of equipment to provide the customer with the best operation. About Rolls-Royce Rolls-Royce is a global business providing integrated power systems for use on land, at sea and in the air. The Group has a balanced business portfolio with leading market positions. Rolls-Royce has a broad range of civil nuclear expertise, including work related to licensing and safety reviews, engineering design

  16. New generation of antidepressants in pregnant women

    Directory of Open Access Journals (Sweden)

    Ladan Kashani

    2007-03-01

    Full Text Available Although pregnancy was once thought to protect against psychiatric disorders, gravid and non gravid women have similar risks for major depression, at 10% to 15%. Both depression and antidepressant treatment during pregnancy have been associated with risks. Few medications have been proved unequivocally safe during pregnancy. Although certain antidepressants have not been linked with an increased risk of birth defects or impaired development including bupropion, citalopram, escitalopram and venlafaxine, the latest studies aren't necessarily reassuring. As researchers continue to learn more about antidepressants, the risks and benefits of taking the drugs during pregnancy must be weighed carefully on a case-by-case basis. This review discusses about the use of new generation of antidepressants in pregnancy

  17. A NEW GENERATION CHEMICAL FLOODING SIMULATOR

    Energy Technology Data Exchange (ETDEWEB)

    Gary A. Pope; Kamy Sepehrnoori; Mojdeh Delshad

    2005-01-01

    The premise of this research is that a general-purpose reservoir simulator for several improved oil recovery processes can and should be developed so that high-resolution simulations of a variety of very large and difficult problems can be achieved using state-of-the-art algorithms and computers. Such a simulator is not currently available to the industry. The goal of this proposed research is to develop a new-generation chemical flooding simulator that is capable of efficiently and accurately simulating oil reservoirs with at least a million gridblocks in less than one day on massively parallel computers. Task 1 is the formulation and development of solution scheme, Task 2 is the implementation of the chemical module, and Task 3 is validation and application. In this final report, we will detail our progress on Tasks 1 through 3 of the project.

  18. New Generation of Los Alamos Opacity Tables

    Science.gov (United States)

    Colgan, James; Kilcrease, D. P.; Magee, N. H.; Sherrill, M. E.; Abdallah, J.; Hakel, P.; Fontes, C. J.; Guzik, J. A.; Mussack, K. A.

    2016-05-01

    We present a new generation of Los Alamos OPLIB opacity tables that have been computed using the ATOMIC code. Our tables have been calculated for all 30 elements from hydrogen through zinc and are publicly available through our website. In this poster we discuss the details of the calculations that underpin the new opacity tables. We also show several recent applications of the use of our opacity tables to solar modeling and other astrophysical applications. In particular, we demonstrate that use of the new opacities improves the agreement between solar models and helioseismology, but does not fully resolve the long-standing `solar abundance' problem. The Los Alamos National Laboratory is operated by Los Alamos National Security, LLC for the National Nuclear Security Administration of the U.S. Department of Energy under Contract No. DE-AC5206NA25396.

  19. Initial Content Validation Results of a New Simulation Model for Flexible Ureteroscopy: The Key-Box.

    Science.gov (United States)

    Villa, Luca; Şener, Tarik Emre; Somani, Bhaskar K; Cloutier, Jonathan; Butticè, Salvatore; Marson, Francesco; Doizi, Steeve; Proietti, Silvia; Traxer, Olivier

    2017-01-01

    We sought to test the content validity of a new training model for flexible ureteroscopy: the Key-Box. Sixteen medical students were randomized to undergo a 10-day training consisting of performing 10 different exercises aimed at learning specific movements with the flexible ureteroscope, and how to catch and release stones with a nitinol basket using the Key-Box (n = 8 students in the training group, n = 8 students in the nontraining control group). Subsequently, an expert endourologist (O.T.) blindly assessed skills acquired by the whole cohort of students through two exercises on ureteroscope manipulation and one exercise on stone capture selected among those used for the training. A performance scale (1-5) assessing different steps of the procedure was used to evaluate each student. Time to complete the exercises was measured. Mann-Whitney Rank Sum test was used for comparisons between the two groups. Mean scores obtained by trained students were significantly higher compared with those obtained by nontrained students (all p six (75%) nontrained students were not able to finish one out of the two exercises on ureteroscope manipulation and the exercise on stone capture, respectively. The mean time to complete the three exercises was 76.3, 69.9, and 107 and 172.5, 137.9, and 168 seconds in the trained and nontrained groups, respectively (all p Box(®) seems to be a valid easy-to-use training model for initiating novel endoscopists to flexible ureteroscopy.

  20. Stent Position Is More Important than ?-Blockers or Anticholinergics for Stent-Related Lower Urinary Tract Symptoms after Ureteroscopic Ureterolithotomy: A Prospective Randomized Study

    OpenAIRE

    Lee, Sun Ju; Yoo, Changhee; Oh, Cheol Young; Lee, Yong Seong; Cho, Sung Tae; Lee, Seong Ho; Yang, Dae Yul; Lee, Sang Kon; Cho, Jin Seon

    2010-01-01

    Purpose To evaluate the clinical factors that impact ureteral stent-related lower urinary tract symptoms (LUTS) after ureteroscopic ureterolithotomy, including the stent position and medication. Materials and Methods Fifty-three patients who underwent ureteroscopic ureterolithotomy with indwelling a stent were distributed into three groups. On demand analgesics were given to the group 1 (n=18). Daily tamsulosin 0.2 mg was added for group 2 (n=15) and daily tamsulosin 0.2 mg and tolterodine 4 ...

  1. Study on Undertaking-starting of New Generation Migrant Workers

    OpenAIRE

    Lu, Chuang; Liu, Wanzhao

    2014-01-01

    New generation migrant workers have become mainstay of China’s migrant workers and also major builders of China’s urbanization process. Compared with last generation migrant workers, new generation migrant workers have greater awareness of starting an undertaking. In the new trend, undertaking-starting is inevitable for new generation migrant workers. This study analyzed problems encountered by new generation migrant workers in the course of starting an undertaking. It reached conclusions...

  2. Boronline, a new generation of boron meter

    Energy Technology Data Exchange (ETDEWEB)

    Pirat, P. [Rolls-Royce Company, Meylan (France)

    2011-07-01

    Rolls-Royce is a global business providing integrated power systems for use on land, at sea and in the air. The Group has a balanced business portfolio with leading market positions - civil aerospace, defence aerospace, marine and energy Rolls-Royce understands the challenges of design, procurement, manufacture, operation and in-service support of nuclear reactor plants, with over 50 years of experience through the Royal Navy submarine programme. Rolls-Royce can therefore offer full product life-cycle management for new civil nuclear installations, as well as support to existing installations, including plant lifetime extensions. Rolls-Royce produced for 40 years, Instrumentation and Control (I and C) systems of and associated services for nuclear reactors in Europe, including 58 French reactors and others situated in the United States and in others countries, such as China. Rolls-Royce equipped in this domain 200 nuclear reactors in 20 countries. Among all of its nuclear systems, Rolls Royce is presenting to the conference its new generation of on-line boron measurement system, so called Boronline. (authors)

  3. Thiomers: a new generation of mucoadhesive polymers.

    Science.gov (United States)

    Bernkop-Schnürch, Andreas

    2005-11-03

    Thiolated polymers or designated thiomers are mucoadhesive basis polymers, which display thiol bearing side chains. Based on thiol/disulfide exchange reactions and/or a simple oxidation process disulfide bonds are formed between such polymers and cysteine-rich subdomains of mucus glycoproteins building up the mucus gel layer. Thiomers mimic therefore the natural mechanism of secreted mucus glycoproteins, which are also covalently anchored in the mucus layer by the formation of disulfide bonds-the bridging structure most commonly encountered in biological systems. So far the cationic thiomers chitosan-cysteine, chitosan-thiobutylamidine as well as chitosan-thioglycolic acid and the anionic thiomers poly(acylic acid)-cysteine, poly(acrylic acid)-cysteamine, carboxy-methylcellulose-cysteine and alginate-cysteine have been generated. Due to the immobilization of thiol groups on mucoadhesive basis polymers, their mucoadhesive properties are 2- up to 140-fold improved. The higher efficacy of this new generation of mucoadhesive polymers in comparison to the corresponding unmodified mucoadhesive basis polymers could be verified via various in vivo studies on various mucosal membranes in different animal species and in humans. The development of first commercial available products comprising thiomers is in progress. Within this review an overview of the mechanism of adhesion and the design of thiomers as well as delivery systems comprising thiomers and their in vivo performance is provided.

  4. Frequency of Stent Placement after Ureteroscopic Lithotripsy in a University and a State Hospital

    Directory of Open Access Journals (Sweden)

    Huseyin Celik

    2016-03-01

    Full Text Available Objective: The aim of this study was to compare frequen­cy of ureteral stent placement after ureteroscopic litho­tripsy in a university and a state hospital of two different cities, which are endemic in terms of stone and often ure­terolithotripsy was performed for urolithiasis treatment. Methods: The patients who applied in to urology clinic of Inonu University Turgut Ozal Medical Center (TOMC and urology clinic of Osmaniye State Hospital (OSH between January 2014 and May 2014 were evaluated retrospec­tively. The patients who underwent ureteroscopic lithotrip­sy due to ureteral stone, were evaluated stone locations, stone sizes, grades of pelvicaliectasia and ureteral stent placement status. Results: About 92 patients were enrolled into the study from the both hospital. After the endoscopic ureteral stone treatment, Double J stent was placed in 85 patients in TOMC (92.3% and 82 patients in OSH (89.1%. Stent im­plantation rate in the university hospital was higher than the state hospital but this was not statistically significant. There was a statistically meaningful difference in mean operative time between the 2 groups. Conclusion: Double J stent placament is recently per­formed too often after the endoscopic ureteral stone treat­ment. According to our study, university hospitals have a higher rate of incidence of double j stent placement ac­cording to state hospitals. It can be reason for that, uni­versity hospitals as the last line treatment centers, more complicated cases that refer to these centers. But in this matter, prospective, multicenter and larger series studies are needed.

  5. Pneumatic versus laser ureteroscopic lithotripsy: a comparison of initial outcomes and cost.

    Science.gov (United States)

    Demir, Aslan; Karadağ, Mert Ali; Ceçen, Kurşat; Uslu, Mehmet; Arslan, Omer Erkam

    2014-11-01

    To audit the cost of laser versus pneumatic semirigid ureteroscopic lithotripsy and to analyze their relative initial outcomes and cost. Hundred and eighty-seven patients who underwent semirigid ureteroscopic lithotripsy were analyzed retrospectively in terms of age and sex of the patients; location and size of the stones; the type of probe and ancillary equipment such as guide wire, basket catheter, JJ stent requirements; irrigation amount; operation time; the cost of the anesthesia and further treatments such as a JJ stent removal operation and shock wave lithotripsy requirements and their costs. Two groups were formed based on this type of lithotripters, pneumatic and laser lithotripsy. Operation times (min.) in terms of the stone size, for stones 100 mm(2) were 20.75 ± 10.78 and 25.82 ± 14.23, respectively (p = 0.007). Operation times for the pneumatic and laser groups were 33.05 ± 11.36 and 15.25 ± 6.14, respectively (p pneumatic and laser groups were 89.6 % (n = 69) and 98.2 % (n = 108), respectively (p = 0.01). The mean cost of the operations for each of the study groups was 261.5 ± 66.13 and 311.7 ± 51.97 US$, respectively (p = 0.001). The mean cost in terms of the stone size, for stones 100 mm(2), was 272.86 ± 53.05 and 323.71 ± 66.88 US$, respectively (p = 0.01). It seems that usage of laser lithotripsy (LL) in patients with ureteral stones is more effective than pneumatic lithotripsy (PL) in terms of operation time and SF rate. On the other hand, the mean cost of LL seems to be more expensive than PL. Urologists should think these parameters before the choice of these two treatment modalities. The higher the effectiveness, the greater the cost.

  6. Study on Undertaking-starting of New Generation Migrant Workers

    Institute of Scientific and Technical Information of China (English)

    Chuang; LU; Wanzhao; LIU

    2014-01-01

    New generation migrant workers have become mainstay of China’s migrant workers and also major builders of China’s urbanization process. Compared with last generation migrant workers,new generation migrant workers have greater awareness of starting an undertaking. In the new trend,undertaking-starting is inevitable for new generation migrant workers. This study analyzed problems encountered by new generation migrant workers in the course of starting an undertaking. It reached conclusions that competent authorities should set up support mechanism in undertaking-starting training,undertaking-starting fund,service platform,and preferential policies,to encourage and support new generation migrant workers to start an undertaking.

  7. Genome Maps, a new generation genome browser.

    Science.gov (United States)

    Medina, Ignacio; Salavert, Francisco; Sanchez, Rubén; de Maria, Alejandro; Alonso, Roberto; Escobar, Pablo; Bleda, Marta; Dopazo, Joaquín

    2013-07-01

    Genome browsers have gained importance as more genomes and related genomic information become available. However, the increase of information brought about by new generation sequencing technologies is, at the same time, causing a subtle but continuous decrease in the efficiency of conventional genome browsers. Here, we present Genome Maps, a genome browser that implements an innovative model of data transfer and management. The program uses highly efficient technologies from the new HTML5 standard, such as scalable vector graphics, that optimize workloads at both server and client sides and ensure future scalability. Thus, data management and representation are entirely carried out by the browser, without the need of any Java Applet, Flash or other plug-in technology installation. Relevant biological data on genes, transcripts, exons, regulatory features, single-nucleotide polymorphisms, karyotype and so forth, are imported from web services and are available as tracks. In addition, several DAS servers are already included in Genome Maps. As a novelty, this web-based genome browser allows the local upload of huge genomic data files (e.g. VCF or BAM) that can be dynamically visualized in real time at the client side, thus facilitating the management of medical data affected by privacy restrictions. Finally, Genome Maps can easily be integrated in any web application by including only a few lines of code. Genome Maps is an open source collaborative initiative available in the GitHub repository (https://github.com/compbio-bigdata-viz/genome-maps). Genome Maps is available at: http://www.genomemaps.org.

  8. Genome Maps, a new generation genome browser

    Science.gov (United States)

    Medina, Ignacio; Salavert, Francisco; Sanchez, Rubén; de Maria, Alejandro; Alonso, Roberto; Escobar, Pablo; Bleda, Marta; Dopazo, Joaquín

    2013-01-01

    Genome browsers have gained importance as more genomes and related genomic information become available. However, the increase of information brought about by new generation sequencing technologies is, at the same time, causing a subtle but continuous decrease in the efficiency of conventional genome browsers. Here, we present Genome Maps, a genome browser that implements an innovative model of data transfer and management. The program uses highly efficient technologies from the new HTML5 standard, such as scalable vector graphics, that optimize workloads at both server and client sides and ensure future scalability. Thus, data management and representation are entirely carried out by the browser, without the need of any Java Applet, Flash or other plug-in technology installation. Relevant biological data on genes, transcripts, exons, regulatory features, single-nucleotide polymorphisms, karyotype and so forth, are imported from web services and are available as tracks. In addition, several DAS servers are already included in Genome Maps. As a novelty, this web-based genome browser allows the local upload of huge genomic data files (e.g. VCF or BAM) that can be dynamically visualized in real time at the client side, thus facilitating the management of medical data affected by privacy restrictions. Finally, Genome Maps can easily be integrated in any web application by including only a few lines of code. Genome Maps is an open source collaborative initiative available in the GitHub repository (https://github.com/compbio-bigdata-viz/genome-maps). Genome Maps is available at: http://www.genomemaps.org. PMID:23748955

  9. DIDACTIC ENGINEERING: DESIGNING NEW GENERATION LEARNING SYSTEMS

    Directory of Open Access Journals (Sweden)

    Nail K. Nuriyev

    2016-09-01

    Full Text Available Introduction: the article deals with the organisation of training activities in the man-made environment. Didactic engineering is seen as a methodology within which problems of didactics are solved with application of pedagogical, psychological, engineering methods. It is obvious that in order to implement the training of future engineers in a competence-based format (according to educational standard a new type of teaching system is needed, with new capacities (properties. These systems should set each student towards the development of professionally significant (key abilities, taking into account his/her psychological characteristics; ensure training on the verge of permissible difficulties (developing training, and thereby achieve rapid development of key skills, through his/her zone of “immediate development”; to diagnose the quality of possession of a competence in the academic sense. For the objectivity and reliability of assessment of the level and depth of learned knowledge it is necessary to generate this evaluation in a metric format. As a result, we created a didactic system, which combines all the listed properties and the properties of classical systems. This allowed us to construct a new generation of didactic systems. Materials and Methods: the research is based on a systematic analysis of the activity of an engineer; on models of “zones of immediate development” by L. S. Vygotsky; on “developmental education” by L. N. Zankova; on the use of pedagogical and psychological patterns as well as taxonomic methods, didactic engineering, theory of probability and mathematical statistics. Results: constructed is a model for training engineers in the metric format of competence, which envisages a rapid development of students project and constructive abilit ies based on their knowledge learned. Discussion and Conclusions: the parameters defining the probability of engineer’s success have been described; the taxonomic scale

  10. Hardness Assurance Techniques for New Generation COTS Devices

    Science.gov (United States)

    Lee, C. I.; Rax, B. G.; Johnston, A. H.

    1996-01-01

    Hardness Assurance (HA) techniques and total dose radiation characterization data for new generation linear and COTS devices from various manufacturers are presented. A bipolar op amp showed significant degradation at HDR, not at low dose rate environment. New generation low-power op amps showed more degradation at low voltage applications. HA test techniques for COTS devices are presented in this paper.

  11. Changes in Management to Fit the Working Style of the New Generations

    Directory of Open Access Journals (Sweden)

    Gheorghe Popovici

    2016-06-01

    Full Text Available The paper presents the results of the study about the changes in modern management meant to fit the working style of the new generations. This survey forwards the results and recommendations for such a management that present and future managers may take into account in the relations with young generations. Each generation is different from the other by certain specific traits related to the life and working style of new generations of youth. Among these recommendations presented we may list: flexibility of working hours, assurance of a balance between professional and personal life of the young employees, assurance of the package of opportunities: financial gains, professional development and creative working atmosphere etc. The young generations may no longer be seen as mere “human resources”, but people with expectations and behaviours which define modern management.

  12. An Inquiry into Cultivation of New-generation Farmers

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    This article expounds the necessity of the transformation from traditional farmers to modern new farmers: the building of new socialist countryside needs modern new farmers; the coordination of urban-rural integration development needs the transformation from traditional farmers to modern new farmers; the development of modern agriculture needs the transformation from traditional farmers to modern new farmers. Then it analyses the characteristics and role of new-generation farmers, and presents the way to accelerate cultivation of new-generation farmers: make sound laws and regulations, to lay solid foundation for cultivation of new-generation farmers; create conditions, to provide funds guarantee for cultivation of new-generation farmers; make scientific planning, to promote regular, systematized and standardized training work for new-generation farmers; focus on education, to promote the overall quality of new-generation farmers; innovate upon content, to meet the needs of development of new-generation farmers; highlight focus, to intensify competitiveness training for returning-home migrant workers.

  13. Review and Prospect of Development Capability of New Generation Farmers

    Institute of Scientific and Technical Information of China (English)

    Shukun WANG; Shaojun CHEN

    2015-01-01

    In the context of dual economic structure,there occurs shift of numerous rural surplus labors in China. As a special group lingering about in the edges of urban and rural areas,the new generation farmers become a hot spot of research. How to help them smoothly become successors of China’s agricultural modernization construction is a focus of academic circles. Based on literature review,this paper analyzed connotation of development capability of new generation farmers from agricultural modernization,thinking ability construction,system and policy,and new farmers. Finally,it came up with prospect for development of new generation farmers.

  14. Prospective analysis of a complete retrograde ureteroscopic technique with holmium laser stent cutting for management of encrusted ureteral stents.

    Science.gov (United States)

    Thomas, Alexandre; Cloutier, Jonathan; Villa, Luca; Letendre, Julien; Ploumidis, Achilles; Traxer, Olivier

    2017-03-14

    To propose and evaluate a new endoscopic technique using only a retrograde ureteroscopic approach for the removal of heavily encrusted ureteral stents. Data from 51 consecutive patients with encrusted and retained ureteral stents were prospectively collected. Description of the successive steps of surgery is detailed. The Holmium-YAG laser properties offer the opportunity for fragmentation of stent-attached encrustation and the ability to cut the stent itself. Reducing the length of the stent is critical to creating space in the ureter and to allow free access for ureteroscopes or ureteral access sheath placement. The primary outcome of this study was the feasibility and the safety of this retrograde intra-renal approach. Some factors of encrustation and outcomes are also discussed in comparison with lithotripsy, percutaneous, laparoscopic, open surgery or a combination of these techniques. The removal of the encrusted stent was possible with only this retrograde technique in 98% of patients. The transection of the encrusted stent with the Holmium-YAG laser was useful in 71% of the patients. Mean operative time was 110 minutes and mean hospital stay was 2.33 days. Postoperative complications were mainly non-obstructive pyelonephritis (10%). The most significant predictor of this life threatened complication was the presence of struvite stones with the encrusted stent (p=0,018). Contrariwise, operative time, BMI, gender and encrustation rate were not associated with postoperative pyelonephritis. Cystine stone disease or pregnancy both led to faster stent encrustation. Retrograde ureteroscopic surgery is efficient and safe for removing retained stents and associated stone burdens. The Holmium-YAG laser is essential to perform the encrustation removal and sectioning of the stent.

  15. Formulation of a New Generation of Liposomes from Bacterial and ...

    African Journals Online (AJOL)

    Formulation of a New Generation of Liposomes from. Bacterial and ... Their morphological characteristics were assessed by atomic force microscopy. (AFM). Results: At ..... Moghimipour E, Kargar M, Ramezani Z, Handali S. The potent in vitro ...

  16. Teacher education - meeting the needs of the new generation

    DEFF Research Database (Denmark)

    2014-01-01

    Temanr. fra konferencen: Teacher Education: Meeting the Needs of the New Generation 33rd Annual Seminar of International Society for Teacher Education, Hong Kong Baptist University, Hong Kong, May 27 – 31, 2013......Temanr. fra konferencen: Teacher Education: Meeting the Needs of the New Generation 33rd Annual Seminar of International Society for Teacher Education, Hong Kong Baptist University, Hong Kong, May 27 – 31, 2013...

  17. Management of calculus anuria using ureteroscopic lithotripsy as a first line treatment: its efficacy and safety.

    Science.gov (United States)

    Savić, Slaviša; Vukotić, Vinka; Lazić, Miodrag; Savić, Nataša

    2014-05-06

    To present our experience with emergency ureteroscopic lithotripsy (URSL) for ureteral calculi associated with acute kidney injury (AKI). We retrospectively evaluated the 61 patients consisted of 90 ureteral units (UU), who underwent URSL. The cause of anuria was bilateral calculus obstructions in 29 cases, and unilateral calculus obstruction with, absent, nephrectomized contralateral kidney in 32 cases. In the case of bilateral synchronous ureteric calculi same-session bilateral ureteroscopy (SBBU) was done. The duration of anuria varied between 12 to 72 hours. At the end of the procedure, ureteral stent was systematically left in place in all patients. Surgery was performed 6-12 hours after admission to hospital. Patients were followed at least 1 month postoperatively. The stone free rates (SFR) were determined as baseline, on the first post-operative day, and as overall on the 30 days after procedure. The greatest success was achieved in the distal localization of stones up to 10 mm (93%). Renal function returned in 51 (83.6%) patients within 7 days. In 18 (29.5%) patients [18 (20%) UU] we performed second procedure as extracorporeal shockwave lithotripsy in 16.7% and open surgery in 2.2%. In 43 (70.5%) patients URSL was a successful therapeutic approach in dealing with pain, obstruction and calculus. Calculus anuria is a medical emergency that requires rapid diagnosis and prompt treatment for the purpose of decompression. URSL is the proper method of choice for selected patients and can be performed safely and has high success rates with minimal morbidity.

  18. 输尿管软镜钬激光碎石术后尿源性脓毒血症5例分析及对策%Analysis of 5 cases of urine-induced sepsis afterflexible ureteroscope holmium laser lithotripsy and countermeasures

    Institute of Scientific and Technical Information of China (English)

    毛俊彪; 袁平成; 桂定文; 彭伟; 陈小刚; 张青汉

    2015-01-01

    目的::探讨输尿管软镜钬激光碎石术后尿源性脓毒血症的预防措施,以降低发生率.方法:回顾性分析输尿管软镜钬激光碎石术后出现尿源性脓毒血症5例患者的临床资料:2例诊断为肾盂结石,3例诊断为肾盏结石.结石大小1.5~2.5 cm.术前血常规、肝肾功能、胸片、心电图等均正常,尿常规检查3例正常,2例白细胞5~12个/Hp,术前尿培养4例为阴性,1例患者第一次尿培养为大肠埃希菌,给予敏感抗生素治疗后复查尿培养阴性.患者均在全麻下行输尿管软镜钬激光碎石术.结果:5例患者术后出现不同程度尿脓毒血症,经选用敏感抗生素,并对症支持治疗,患者均痊愈出院.结论:尿源性脓毒血症是输尿管软镜钬激光碎石术后严重的并发症之一.术前充分准备,术中控制手术时间,术后严密监测,以及尽早选用敏感抗生素是防治输尿管软镜钬激光碎石术后尿源性脓毒血的关键.%Objective:To investigate prevention measures of urine-induced sepsis after flexible ureteroscope holmium la-ser lithotripsy in order to reduce the incidence.Methods:The clinical data of 5 cases of urine-induced sepsis after flexible ure-teroscope holmium laser lithotripsy were retrospectively analyzed.Two patients were diagnosed as having pyelolith,and three having calyceal calculus.Stone size was ranged from 1.5-2.5 cm.Blood routine test,hepatorenal function,chest radio-graphy,electrocardiogram before operation were normal.Urinalysis of three patients was normal,and leukocyte count of u-rinalysis was 5-12/Hp in two patients.Urine culture before operation was negative in 4 patients.The first urine culture was positive for Escherichia coli in one patient,and re-examination of urine culture was negative after sensitive antibiotic admin-istration.All patients were subjected to flexible ureteroscope holmium laser lithotripsy under general anesthesia.Results:Five patients had sepsis to varying

  19. New Generation Of Paper For Calligraphy And Painting

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正>Among the calligraphic and painting collections, the new generation of paper which was developed by Yu Chunrong is the best and has enjoyed flavour of the collectors. The paper traced in gold has become an artistic work with inscriptions of famous calligraphers and painters.It is worth collecting.

  20. A new generation videokymography for routine clinical vocal fold examination

    NARCIS (Netherlands)

    Qiu, Qingjun; Schutte, Harm K.

    2006-01-01

    Objective. This study aims to introduce a new-generation videokymographic system, which provides simultaneous laryngoscopic and kymographic image, for routine clinical vocal fold examination. Study Design: The authors explored a new imaging method for diagnosis and evaluation of voice disorders. Met

  1. Adsorbent Carbon Fabrics : New Generation Armour for Toxic Chemicals

    Directory of Open Access Journals (Sweden)

    K. Gurudatt

    1997-04-01

    Full Text Available Activated carbon in the form of a regular fabric obtained using viscose rayon precursor is a new generation adsorbent material having superior sorptional properties and is finding varied defence applications. Carbonisation and activation mechanisms and properties and applications of adsorbent carbort fibres made from viscose rayon precursor are reviewed in this paper.

  2. Large subcapsular hematoma following ureteroscopic laser lithotripsy of renal calculi in a spina bifida patient: lessons we learn

    Directory of Open Access Journals (Sweden)

    Vaidyanathan S

    2016-08-01

    Full Text Available Subramanian Vaidyanathan,1 Azi Samsudin,2 Gurpreet Singh,3 Peter L Hughes,4 Bakul M Soni,1 Fahed Selmi1 1Regional Spinal Injuries Center, Southport and Formby District General Hospital, Southport, UK; 2Department of Urology, Whiston Hospital, Prescot, UK; 3Department of Urology, 4Department of Radiology, Southport and Formby District General Hospital, Southport, UK Introduction: Paraplegic patients are at greater risk of developing complications following ureteroscopic lithotripsy because of urine infection associated with neuropathic bladder, difficulties in access due to altered anatomy of urinary bladder and urethra, spinal curvature, spasticity, and contractures. We report the occurrence of large subcapsular hematoma following ureteroscopy and discuss lessons we learn from this case.Case report: A 48-year-old male patient with spina bifida underwent ureteroscopy with laser lithotripsy and ureteric stenting for left ureteric stone and staghorn calculus with hydronephrosis; laser lithotripsy was repeated after 3 months; both procedures were performed by a senior urologist and did not result in any complications. Ureteroscopic laser lithotripsy was performed 5 months later by a urological trainee; it was difficult to negotiate the scope as vision became poor because of bleeding (as a result of the procedure. Postoperatively, hematuria persisted; temperature was 39°C. Cefuroxime was given intravenously followed by gentamicin for 5 days; hematuria subsided gradually; he was discharged home. Ten days later, this patient developed temperature, the urine culture grew Pseudomonas aeruginosa, and ciprofloxacin was given orally. Computed tomography (CT of the urinary tract, performed 4 weeks after ureteroscopy, revealed a 9×7 cm subcapsular collection on the left kidney compressing underlying parenchyma. Percutaneous drainage was not feasible because of severe curvature of spine. Isotope renogram revealed deterioration in left renal function from 30

  3. Large subcapsular hematoma following ureteroscopic laser lithotripsy of renal calculi in a spina bifida patient: lessons we learn.

    Science.gov (United States)

    Vaidyanathan, Subramanian; Samsudin, Azi; Singh, Gurpreet; Hughes, Peter L; Soni, Bakul M; Selmi, Fahed

    2016-01-01

    Paraplegic patients are at greater risk of developing complications following ureteroscopic lithotripsy because of urine infection associated with neuropathic bladder, difficulties in access due to altered anatomy of urinary bladder and urethra, spinal curvature, spasticity, and contractures. We report the occurrence of large subcapsular hematoma following ureteroscopy and discuss lessons we learn from this case. A 48-year-old male patient with spina bifida underwent ureteroscopy with laser lithotripsy and ureteric stenting for left ureteric stone and staghorn calculus with hydronephrosis; laser lithotripsy was repeated after 3 months; both procedures were performed by a senior urologist and did not result in any complications. Ureteroscopic laser lithotripsy was performed 5 months later by a urological trainee; it was difficult to negotiate the scope as vision became poor because of bleeding (as a result of the procedure). Postoperatively, hematuria persisted; temperature was 39°C. Cefuroxime was given intravenously followed by gentamicin for 5 days; hematuria subsided gradually; he was discharged home. Ten days later, this patient developed temperature, the urine culture grew Pseudomonas aeruginosa, and ciprofloxacin was given orally. Computed tomography (CT) of the urinary tract, performed 4 weeks after ureteroscopy, revealed a 9×7 cm subcapsular collection on the left kidney compressing underlying parenchyma. Percutaneous drainage was not feasible because of severe curvature of spine. Isotope renogram revealed deterioration in left renal function from 30% to 17%. Follow-up CT revealed reduction in the size of subcapsular hematoma, no hydronephrosis, and several residual calculi. Risk of subcapsular hematoma following ureteroscopic lithotripsy can be reduced by avoiding prolonged endoscopy and performing ureteroscopy under low pressure. When a paraplegic patient develops features of infection after ureteroscopy, renal imaging should be carried out promptly

  4. Two-part silicone mold. A new tool for flexible ureteroscopy surgical training

    Directory of Open Access Journals (Sweden)

    Bruno Marroig

    Full Text Available ABSTRACT Introduction and objectives: Flexible ureteroscopy is a common procedure nowadays. Most of the training programs use virtual reality simulators. The aim of this study was to standardize the building of a three-dimensional silicone mold (cavity of the collecting system, on the basis of polyester resin endocasts, which can be used in surgical training programs. Materials and Methods: A yellow polyester resin was injected into the ureter to fill the collecting system of 24 cadaveric fresh human kidneys. After setting off the resin, the kidneys were immersed in hydrochloric acid until total corrosion of the organic matter was achieved and the collecting system endocasts obtained. The endocasts were used to prepare white color two-part silicone molds, which after endocasts withdrawn, enabled a ureteroscope insertion into the collecting system molds (cavities. Also, the minor calices were painted with different colors in order to map the access to the different caliceal groups. The cost of the materials used in the molds is $30.00 and two days are needed to build them. Results: Flexible ureteroscope could be inserted into all molds and the entire collecting system could be examined. Since some anatomical features, as infundular length, acute angle, and perpendicular minor calices may difficult the access to some minor calices, especially in the lower caliceal group, surgical training in models leads to better surgical results. Conclusions: The two-part silicone mold is feasible, cheap and allows its use for flexible ureteroscopy surgical training.

  5. Flexible Flatfoot

    Science.gov (United States)

    ... this page. Please enable Javascript in your browser. Flexible Flatfoot What Is Flatfoot? Flatfoot is often a ... may develop as a result of a flatfoot. Flexible Flatfoot Flexible flatfoot is one of the most ...

  6. MODEL OF AN ELECTRONIC EDUCATIONAL RESOURCE OF NEW GENERATION

    Directory of Open Access Journals (Sweden)

    Anatoliy V. Loban

    2016-01-01

    Full Text Available The mathematical structure of the modular architecture of an electronic educational resource (EER of new generation, which allows to decompose the process of studying the subjects of the course at a hierarchically ordered set of data (knowledge and procedures for manipulating them, to determine the roles of participants of process of training of and technology the development and use of EOR in the study procrate.

  7. The Sketch of a New Generation Launch Vehicle of Long-March Family

    Science.gov (United States)

    Tang, Yihua; Wang, Xiaojun; Cheng, Tangming

    2002-01-01

    To meet the ever-expanding requirements of satellite customers, a new generation launch vehicle of Long-March (LM) family is being studied according to theprinciples of low-cost, high-reliability, and maximum flexibility. With reducing prelaunch processing times, the launch system will strengthen the capability of providing international commercial launching services in the future. The new generation launch system is constructed with some standard modules, while featuring two types of newly developed engines and three new modules with non-toxic, non-polluting propellant. Based on the three modules, 5-m module powered by two 50-ton-thrust engines which burn liquid hydrogen (LH2) and liquid oxygen (LO2), 3.35-m module powered by two 120-ton-thrust engines which burn LO2 and kerosene (KO), and 2.25-m module powered by one 120-ton-thrust engine, first can combine into a serial large-scale launch vehicles with 5-m-dia common core. By modified the modules, next combine into medium launch vehicles with 3.35-m-dia core and a small launch vehicle with 2.25-m-dia core. Then a new group of launch vehicles will be formed to accommodate a wide range of performance requirements, which provide a capable of delivering payloads ranging from 1.5-14 ton to geosynchronous transfer orbit (GTO) and up to 25 ton to low earth orbit (LEO). This paper will highlight the design principles, system concept and serial configurations for the new generation launch system.

  8. Integrating renewable energy sources in the Portuguese power system. New generation adequacy indicators

    Energy Technology Data Exchange (ETDEWEB)

    Martins, Nuno; Santos, Joana; Damas, Manuela [Redes Energeticas Nacionais (REN), Porto (Portugal). Studies and Innovation Dept.

    2012-07-01

    The penetration of intermittent energy sources in the Portuguese power system is growing significantly. The identification of possible solutions to maintain the operational reserve levels is necessary to preserve flexibility and security of electricity supply. In this context, the development of probabilistic tools is essential to calculate new generation adequacy indicators associated with the analysis of the operational reserve. In this paper, the mathematical model RESERVAS, is briefly described and is used to analyse the impact of integrating high levels of intermittent energy sources in the Portuguese power system. The presented results allow us to conclude that the electricity adequacy evaluation should be done using probabilistic indicators, which reflect the power system performance in the following areas: (i) Adequacy (evaluation of the available power to face the hourly electricity demand) and (ii) Security (evaluation of the operational reserve requirements through the deviations in the demand-supply balance that occur among all elementary periods). (orig.)

  9. A new generation of plastic optical fibers and its functional exploiting

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    A major problem of plastic optical fibers(POFs) is large transmission loss in comparison with silica fibers.After adopting a new optical fiber structure,hollow-core Bragg fiber with cobweb-structured cladding,which can suppress the absorption losses of constituent materials by a factor of about 104―106,the problem of POFs with large losses is solved ultimately.With the advantage of flexibility and easy bending,the POFs with this structure can guide light with low transmission loss for information and energy in the wavelength range of visible light to terahertz(THz) wave(0.4―1000μm).This new generation of POFs will find many applications

  10. Flexible supercapacitors

    Institute of Scientific and Technical Information of China (English)

    Shan Shi; Chengjun Xu; Cheng Yang; Jia Li; Hongda Du; Baohua Li; Feiyu Kang

    2013-01-01

    Flexible supercapacitors show a great potential for applications in wearable,miniaturized,portable,largescale transparent and flexible consumer electronics due to their significant,inherent advantages,such as being flexible,lightweight,low cost and environmentally friendly in comparison with the current energy storage devices.In this report,recent progress on flexible supercapacitors,flexible electrodes and electrolytes is reviewed.In addition,the future challenges and opportunities are discussed.

  11. Achievements of New Generation Steel Project in China

    Institute of Scientific and Technical Information of China (English)

    Weng Yuqing

    2004-01-01

    Major achievements of the national project, Fundamental Research on New Generation of Iron and Steel Materials in China (NG Steel), are reviewed in the paper. Ultrafine grained steel technology, based on deformation induced ferrite transformation (DIFT)and successive microstructure changes, is illustrated for grain refinement in both plain low carbon steel and microalloyed steel. Delayed fracture resistance of alloy structure steel can be improved through prior austenite grain refinement. It is shown by results that nano scale precipitates play an important role to grain refinement in thin slab casting and rolling (TSCR)process. Progresses on super cleanliness, high homogeneity, welding and metallurgical process simulation are also briefly introduced.

  12. DEVELOPING A NEW GENERATION OF HIGH PERFORMANCE COMPOSITE CEMENT

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    This paper proposed a new generation of high performance composite cement which is designed according to the optimization of composition and structure of cement paste and is manufactured by blending the different components with special composite techniques. Each of these components has its different special property, and should be compatible with each other and match each other, and the properties of them are complementary mutually. At present, such kind of high performance composite cement can be manufactured with high reactivity cement clinker, ground granulated blast-furnace slag, high grade fly ash, silica fume etc.

  13. Developing a New Generation of Antimicrobial and Bioactive Dental Resins.

    Science.gov (United States)

    Cheng, L; Zhang, K; Zhang, N; Melo, M A S; Weir, M D; Zhou, X D; Bai, Y X; Reynolds, M A; Xu, H H K

    2017-07-01

    Dental caries is prevalent, and secondary caries causes restoration failures. This article reviews recent studies on developing a new generation of bioactive resins with anticaries properties. Extensive effects were made to develop new antimicrobial composites, bonding agents, and other resins containing quaternary ammonium methacrylates to suppress plaque buildup and bacterial acid production. The effects of alkyl chain length and charge density and the antimicrobial mechanisms for chlorhexidine, nano-silver, quaternary ammonium methacrylates, and protein-repellent agents were discussed. Synergistic effects of contact-killing and protein-repellent properties were shown to yield the greatest biofilm-inhibition effects. The combination of antimicrobial, protein-repellent, and calcium phosphate nanoparticle remineralization was suggested to provide maximal anticaries effects. In addition, for use orally, cytotoxicity and biocompatibility were important considerations for the new bioactive materials. Furthermore, rather than kill all bacteria, it would be more desirable to modulate the oral biofilm compositions via bioactive resins to suppress cariogenic/pathogenic species and promote benign species. For widespread clinical use of the new antimicrobial and therapeutic materials, whether they would induce bacterial drug resistance needs to be determined, which requires further study. Nonetheless, the new generation of bioactive anticaries resins with therapeutic and biofilm acid-inhibiting properties has the potential to substantially benefit oral health.

  14. Creating a healthy workplace for new-generation nurses.

    Science.gov (United States)

    Lavoie-Tremblay, Mélanie; Wright, David; Desforges, Nicole; Gélinas, Céline; Marchionni, Caroline; Drevniok, Ulrika

    2008-01-01

    To examine dimensions of the psychosocial work environment that influence the psychological health of new-generation nurses. While much work has been done concerning the health of nurses in general, research on the relationship between the nursing work environment and the psychological well-being of new-generation nurses at the start of their careers is limited. A correlational descriptive design was used for this quantitative study. Survey data were collected from new nurses (N=309) whose names were obtained from a provincial licensing registry in Quebec, Canada. Among new nurses, 43.4% stated that they have a high level of psychological distress. These nurses were significantly more likely to perceive an imbalance between effort expended on the job and rewards received, low decisional latitude, high psychological demands, high job strain, as well as low social support from colleagues and superiors (p generation nurses is imperative for creating interventions to successfully recruit and retain these young nurses. Generation Y nurses in Quebec, faced with high levels of psychological distress because of their exposure to difficult nursing work environments, might leave the profession thereby exacerbating an already salient nursing shortage.

  15. Cost efficient SAGD heave monitoring: new generation radar technology

    Energy Technology Data Exchange (ETDEWEB)

    Granda, Johanna; Arnaud, Alain; Payas, Blanca; Katsuris, Dimitra; Cooksley, Geraint [Altamira Information (Canada)

    2011-07-01

    Oil sands operations are subject to various regulations, one of them being the obligation to monitor heave monuments or other surfaces. Besides meeting the Energy Resources Conservation Board (ERCB) requirements, heave monitoring is efficient in steam chamber monitoring and guaranteeing the safety of SAGD operations. Several techniques exist for heave monitoring, such as GPS-measurement and Interferometry for synthetic aperture readar (InSAR). This paper aimed at presenting the InSAR technology and the advances made with the new generation X-band satellite technology. Two studies were conducted: one in an SAGD steam injection area in Alberta, Canada, and the other in a CO2 storage site in In Salah, Algeria. The new generation X-band radar satellites showed some advantages over traditional techniques, with: redundancy of satellites, frequency of images, measurement precision, a higher resolution and a smaller size of corner reflectors. The InSAR technology presented herein is a cost efficient technique allowing heavy oil operators to comply with ERCB requirements.

  16. Strategic flexibility

    OpenAIRE

    Kim, KiHyung

    2014-01-01

    A flexible system is defined as one that can change the entity's stance, capability or status reacting to a change of the entity's environment. Flexibility has gathered the attention of academic researchers and industry practitioners as an efficient approach to cope with today's volatile environment. As the environments become more unpredictable and volatile, it is imperative for a flexible system to respond quickly to a change in its circumstance. How much flexibility is embedded into the sy...

  17. A new generation control system for astrophysical instruments

    Science.gov (United States)

    Cirami, R.; Comari, M.; Corte, C.; Di Marcantonio, P.; Pucillo, M.; Santin, P.; Vuerli, C.

    A new generation control system for telescopes and astrophysical instruments, both by the software and hardware point of view, has been developed and tested at the laboratories of INAF-Astronomical Observatory of Trieste. In this paper we present a working prototype of such a system: a lightweight, portable, adaptive system, based on the most diffuse standards; such a prototype can be used as a general purpose building block in the design of new instruments. The software environment is based on Linux, Java and CORBA for the communications among the components of the system. The hardware has been chosen among COTS components; in particular the prototype presented here runs on a PC104+ platform.

  18. BUILDING A NEW GENERATION SCIENCE LIBRARY: THE KAUST STORY

    KAUST Repository

    Al Zahrani, Rashed

    2012-06-01

    If you had the opportunity to build a science library from scratch for a new generation of researchers and students, what would it look like and how would it operate? We will show you the vision and reality of the new King Abdullah University of Science and Technology (KAUST) Library that won the 2011 ALA/AIA Library Architecture award and that for the last three years has been providing a high level of information services to top level international scientists and graduate students. We will describe the major characteristics in contemporary science research, education, and information management that guided the design of our library facility, technical infrastructure, and services. We will give concrete examples and evaluations of our implementation of new information services and tools. And we will end with the challenges still before us, most notably the effective integration of science knowledge management into the workflow of scientific research and enterprise based information technology organization.

  19. Environmental Evaluation of New Generation Vehicles and Vehicle Components

    Energy Technology Data Exchange (ETDEWEB)

    Schexnayder, S.M.

    2002-02-06

    This report documents assessments that address waste issues and life cycle impacts associated with the vehicle materials and vehicle technologies being developed under the Partnership for a New Generation of Vehicles (PNGV) program. We refer to these vehicles as 3XVs, referring to the PNGV goal that their fuel mileage be three times better than the baseline vehicle. To meet the program's fuel consumption goals, these vehicles substitute lightweight materials for heavier materials such as steel and iron that currently dominate the composition of vehicles, and use engineering and power system changes. Alternative power systems being developed through the PNGV program include batteries for hybrid electric vehicles and fuel cells. With respect to all these developments, it is imperative to learn what effects they will have on the environment before adopting these designs and technologies on a large-scale basis.

  20. A new generation of medical cyclotrons for the 90`s

    Energy Technology Data Exchange (ETDEWEB)

    Milton, B.F.

    1995-08-01

    Cyclotrons continue to be efficient accelerators for use in radio-isotope production. In recent years, developments in accelerator technology have greatly increased the practical beam current in these machines while also improving the overall system reliability. These developments combined with the development of new isotopes for medicine and industry, and a retiring of older machines indicates a strong future for commercial cyclotrons. In this paper the authors will survey recent developments in the areas of cyclotron technology as they relate to the new generation of commercial cyclotrons. Existing and potential markets for these cyclotrons will be presented. They will also discuss the possibility of systems capable of extracted energies up to 150 MeV and extracted beam currents of up to 2.0 mA.

  1. Salvage Therapy of Multiple Myeloma: The New Generation Drugs

    Directory of Open Access Journals (Sweden)

    Alessandra Romano

    2014-01-01

    Full Text Available During the past decade, overall results of treatment of multiple myeloma (MM have been improved and survival curves are now significantly better with respect to those obtained with historical treatment. These improvements are linked to a deeper knowledge of the biology of disease and to the introduction in clinical practice of drugs with different mechanism of action such as proteasome inhibitors and immunomodulatory drugs (IMiDs. However, MM remains in most cases an incurable disease. For patients who relapse after treatment with novel agents, the prognosis is dismal and new drugs and therapeutic strategies are required for continued disease control. In this review, we summarize new insights in salvage therapy for relapsed/refractory MM as emerging from recent clinical trials exploring the activity of bendamustine, new generation proteasome inhibitors, novel IMiDs, monoclonal antibodies, and drugs interfering with growth pathways.

  2. A New Generation of Uprisings – from Tunisia to Slovenia

    Directory of Open Access Journals (Sweden)

    Andrej Kurnik

    2013-03-01

    Full Text Available The uprising in Tunisia, the occupation of public squares in Spain, the Occupy Wall Street movement, the global uprising on 15 October 2011 and the recent widespread demonstrations in Slovenia can be understood as the new generation of uprisings following the eruption of financial crisis. Those multitudinal expressions of indignation and quests for real democracy are expressions of the irreversible crisis of neoliberalism and representative democracy. From an examination of the defining traits of uprisings from Tunisia to Slovenia, one can define basic theoretical and practical dilemmas in the new ways of doing political encounters. These include the relationship between the social and political dimensions of uprisings, the relationship between heterogeneity and forms of political organization, how resistance against financialization prefigures emerging forms of direct democracy, how emerging movements address the issue of direct democracy and minority rights, and what theoretical practices can prevent the attenuation of the discourse of uprisings and enable the free production of enunciations.

  3. New generation VNIR/SWIR/TIR airborne imaging spectrometer

    Science.gov (United States)

    Wang, Yueming; Wei, Liqin; Yuan, Liyin; Li, Chunlai; Lv, Gang; Xie, Feng; Han, Guicheng; Shu, Rong; Wang, Jianyu

    2016-10-01

    Imaging spectrometer plays an important role in the remote sensing application. Imaging spectrometer can collects and provides a unique spectral signature of many materials. The spectral signature may be absorbing, reflecting, and emitting. Generally, optical spectral bands for earth observing consist of VNIR, SWIR, TIR/LWIR. VNIR band imaging spectrometer is well-known in vegetation remote sensing and ocean detection. SWIR band imaging spectrometer is widely applied in mineralogy investigation. For its uniquely capability of spectral radiance measurement, TIR/LWIR imaging spectrometer attracts much attention these years. This paper will present a new generation VNIR/SWIR/TIR imaging spectrometer. The preliminary result of its first flight will also be shared. The spectral sampling intervals of VNIR/SWIR/TIR are 2.4nm/3nm/30nm, respectively. The spatial pixel numbers are 2800/1400/700,respectively. It's a push-broom imaging spectrometer.

  4. Flexible Ablators

    Science.gov (United States)

    Stackpoole, Margaret M. (Inventor); Ghandehari, Ehson M. (Inventor); Thornton, Jeremy J. (Inventor); Covington, Melmoth Alan (Inventor)

    2017-01-01

    A low-density article comprising a flexible substrate and a pyrolizable material impregnated therein, methods of preparing, and devices using the article are disclosed. The pyrolizable material pyrolizes above 350 C and does not flow at temperatures below the pyrolysis temperature. The low-density article remains flexible after impregnation and continues to remain flexible when the pyrolizable material is fully pyrolized.

  5. Flexible Software for Flexible Scheduling

    Science.gov (United States)

    Economou, Frossie; Jenness, Tim; Tilanus, Remo P. J.; Hirst, Paul; Adamson, Andy J.; Rippa, Mathew; Delorey, Kynan K.; Isaak, Kate G.

    The JAC Observation Management Project (OMP) provides software for the James Clerk Maxwell (JCMT) and the United Kingdom Infrared (UKIRT) telescopes that manages the life-cycle of flexibly scheduled observations. Its aim is to increase observatory efficiency under flexible (queue) scheduled observing, without depriving the principal investigator (PI) of the flexibility associated with classical scheduling.

  6. Titanium: A New Generation Material for Architectural Applications

    Directory of Open Access Journals (Sweden)

    Anjali Acharya

    2015-02-01

    Full Text Available Advanced Materials are defined as unique combinations of materials, process technologies, that together, help create and capture value by addressing large, global unmet wants and needs of building industry. There is a wide range of innovation enabled by technologies for processing materials and integrating currently available materials for creation of new generation buildings “Titaniun” is one of them. It is an incredibly durable and stunning material known for its wide-range of color, high-tensile strength. Titanium can be processed to achieve a variety of surface textures, from a soft matte to a near gleaming reflectivity suitable for architectural application. Titanium's corrosion immunity, strength and physical properties combine to allow reduced wall thickness, lowering its installed unit cost which is favourable as far as its application in densely populated urban areas is concerned. Many countries like United Sates of America, China, and Spain etc have also stared its use however its use in developing country like India is still limited. The paper attempts to analyze the chemical properties of Titanium as a futuristic building material. It also observes the variant of the material as option to make self-cleaning buildings in the future, reducing the amount of harmful cleansers used currently.

  7. New generation fiber reinforced polymer composites incorporating carbon nanotubes

    Science.gov (United States)

    Soliman, Eslam

    The last five decades observed an increasing use of fiber reinforced polymer (FRP) composites as alternative construction materials for aerospace and infrastructure. The high specific strength of FRP attracted its use as non-corrosive reinforcement. However, FRP materials were characterized with a relatively low ductility and low shear strength compared with steel reinforcement. On the other hand, carbon nanotubes (CNTs) have been introduced in the last decade as a material with minimal defect that is capable of increasing the mechanical properties of polymer matrices. This dissertation reports experimental investigations on the use of multi-walled carbon nanotubes (MWCNTs) to produce a new generation of FRP composites. The experiments showed significant improvements in the flexure properties of the nanocomposite when functionalized MWCNTs were used. In addition, MWCNTs were used to produce FRP composites in order to examine static, dynamic, and creep behavior. The MWCNTs improved the off-axis tension, off-axis flexure, FRP lap shear joint responses. In addition, they reduced the creep of FRP-concrete interface, enhanced the fracture toughness, and altered the impact resistance significantly. In general, the MWCNTs are found to affect the behaviour of the FRP composites when matrix failure dominates the behaviour. The improvement in the mechanical response with the addition of low contents of MWCNTs would benefit many industrial and military applications such as strengthening structures using FRP composites, composite pipelines, aircrafts, and armoured vehicles.

  8. Sulfur Flow Analysis for New Generation Steel Manufacturing Process

    Institute of Scientific and Technical Information of China (English)

    HU Chang-qing; ZHANG Chun-xia; HAN Xiao-wei; YIN Rui-yu

    2008-01-01

    Sulfur flow for new generation steel manufacturing process is analyzed by the method of material flow analysis,and measures for SO2 emission reduction are put forward as assessment and target intervention of the results.The results of sulfur flow analysis indicate that 90% of sulfur comes from fuels.Sulfur finally discharges from the steel manufacturing route in various steps,and the main point is BF and BOF slag desulfurization.In sintering process,the sulfur is removed by gasification,and sintering process is the main source of SO2 emission.The sulfur content of coke oven gas (COG) is an important factor affecting SO2 emission.Therefore,SO2 emission reduction should be started from the optimization and integration of steel manufacturing route,sulfur burden should be reduced through energy saving and consumption reduction,and the sulfur content of fuel should be controlled.At the same time,BF and BOF slag desulfurization should be optimized further and coke oven gas and sintering exhausted gas desulfurization should be adopted for SO2 emission reduction and reuse of resource,to achieve harmonic coordination of economic,social,and environmental effects for sustainable development.

  9. New generation of content addressable memories for associative processing

    Science.gov (United States)

    Lewis, H. G., Jr.; Giambalov, Paul

    2000-05-01

    Content addressable memories (CAMS) store both key and association data. A key is presented to the CAN when it is searched and all of the addresses are scanned in parallel to find the address referenced by the key. When a match occurs, the corresponding association is returned. With the explosion of telecommunications packet switching protocols, large data base servers, routers and search engines a new generation of dense sub-micron high throughput CAMS has been developed. The introduction of this paper presents a brief history and tutorial on CAMS, their many uses and advantages, and describes the architecture and functionality of several of MUSIC Semiconductors CAM devices. In subsequent sections of the paper we address using Associative Processing to accommodate the continued increase in sensor resolution, number of spectral bands, required coverage, the desire to implement real-time target cueing, and the data flow and image processing required for optimum performance of reconnaissance and surveillance Unmanned Aerial Vehicles (UAVs). To be competitive the system designer must provide the most computational power, per watt, per dollar, per cubic inch, within the boundaries of cost effective UAV environmental control systems. To address these problems we demonstrate leveraging DARPA and DoD funded Commercial Off-the-Shelf technology to integrate CAM based Associative Processing into a real-time heterogenous multiprocessing system for UAVs and other platforms with limited weight, volume and power budgets.

  10. Development of Vi conjugate - a new generation of typhoid vaccine.

    Science.gov (United States)

    Szu, Shousun Chen

    2013-11-01

    Typhoid fever remains to be a serious disease burden worldwide with an estimated annual incidence about 20 million. The licensed vaccines showed moderate protections and have multiple deficiencies. Most important of all, none of the licensed typhoid vaccines demonstrated protection for children under 5 years old. These limitations impeded successful implementation of typhoid vaccination programs. To improve immunogenicity Vi was conjugated to rEPA, a recombinant exoprotein A from Pseudomonas aeruginosa. Vi-rEPA showed higher and longer lasting anti-Vi IgG in adults and children than Vi alone in high endemic areas. In school-age children and adults, the immunity persisted more than 8 years. In a double-blind, placebo-controlled and randomized efficacy trial in 2- to 5-year-old children, Vi-rEPA conferred 89% protective efficacy against typhoid fever and the protection lasted at least 4 years. When given concomitantly with infant routine vaccines, Vi-rEPA was safe, immunogenic and showed no interference with the routine vaccines. Vi conjugate vaccine was also attempted and successfully demonstrated by several other laboratories and manufactures. Using either rEPA or different carrier proteins, such as diphtheria or tetanus toxoid, recombinant diphtheria toxin (CRM197), the Vi conjugates synthesized was significantly more immunogenic than Vi alone. Recently, two Vi-tetanus toxoid conjugates were licensed in India for all ages, starts as young as 3 month old. This new generation of typhoid vaccine opens up a new era for typhoid prevention and elimination.

  11. Concept design of a new generation military vehicle

    Science.gov (United States)

    Cantemir, Codrin-Gruie; Ursescu, Gabriel; Serrao, Lorenzo; Rizzoni, Giorgio; Bechtel, James; Udvare, Thomas; Letherwood, Mike

    2006-05-01

    This paper presents the development of an advanced concept for a next generation military vehicle based on state of the art technologies. The vehicle's platform will be directly suitable for high mobility applications for instance: Special Forces missions, Marine reconnaissance missions, and commercial racing in events such as Bajas and the Paris - Dakar. The platform will be a 10000 -14000 lbs high-speed multi-purpose vehicle, designed for extreme off-road operation. A completely new suspension concept is expected to be developed and the new vehicle topology will accommodate a new generation hybrid-electric power train. The dynamic performance targets are 125 mph off-road and 0-60 in 7 seconds. The concept design will focus also on survivability mainly through the use of a new vehicle topology (herein referred to as "island") specifically designed to enhance crew protection. The "island" topology consists in locating the powertrain and other vehicle equipment and subsystems around the crew compartment. Thus, even in the event of an external shield penetration the crew compartment remains protected by the surrounding equipment which serves in an additional role as a secondary shield. The paper presents vehicle specifications, performance capabilities, simulation models and virtual models of the vehicle.

  12. New generation of breast cancer clinical trials implementing molecular profiling

    Institute of Scientific and Technical Information of China (English)

    Dimitrios Zardavas; Martine Piccart-Gebhart

    2016-01-01

    The implementation of molecular profiling technologies in oncology deepens our knowledge for the molecular landscapes of cancer diagnoses, identifying aberrations that could be linked with specific therapeutic vulnerabilities. In particular, there is an increasing list of molecularly targeted anticancer agents undergoing clinical development that aim to block specific molecular aberrations. This leads to a paradigm shift, with an increasing list of specific aberrations dictating the treatment of patients with cancer. This paradigm shift impacts the field of clinical trials, since the classical approach of having clinico-pathological disease characteristics dictating the patients' enrolment in oncology trials shifts towards the implementation of molecular profiling as pre-screening step. In order to facilitate the successful clinical development of these new anticancer drugs within specific molecular niches of cancer diagnoses, there have been developed new, innovative trial designs that could be classified as follows: i) longitudinal cohort studies that implement (or not) "nested" downstream trials, 2) studies that assess the clinical utility of molecular profiling, 3) "master" protocol trials, iv) "basket" trials, v) trials following an adaptive design. In the present article, we review these innovative study designs, providing representative examples from each category and we discuss the challenges that still need to be addressed in this era of new generation oncology trials implementing molecular profiling. Emphasis is put on the field of breast cancer clinical trials.

  13. The double wire technique: an alternative method for difficult ureteroscopic access.

    Science.gov (United States)

    Bostanci, Yakup; Ozden, Ender; Atac, Fatih; Yakupoglu, Yarkin Kamil

    2012-12-01

    We read with great interest the study report by Ji et al. (Urol Res, doi: 10.1007/s00240-012-0476-0 , 2012) about the impact of the intentional ureteral stenting on the success rate of calculus extraction by second ureteroscopy, when the initial ureteroscopy failed. Actually, sometimes ureteral stone treatment pose challenging problems for the urologists. This study has filled an important gap on this field. If flexible ureteroscopy and laser lithotripter are not available pre-existing stent may improve the success rate of a subsequent ureteroscopy for impacted ureteral stones. Because, post-stent ureteroscopy has the advantage of working through a dilated ureter. We would like to add some additional comments and suggestions in addition to the authors' discussion, which is noteworthy in several respects.

  14. Challenges and opportunities for recruiting a new generation of neurosurgeons.

    Science.gov (United States)

    Brown, Ann J; Friedman, Allan H

    2007-12-01

    Several factors have converged to raise concern among program directors about attracting and training the next generation of neurosurgeons. These include the relatively new duty-hour regulations, the projected physician shortage, and the preference of many current medical students for controllable lifestyles. Attracting top talent into training programs may require innovations geared to Generation X such as policies supporting work-life balance, flexible work options, lots of feedback, mentoring programs, talented leadership, and standardized communication strategies during patient handoffs. Larger programmatic changes may also be needed such as "competency-based" training and additional years of training for mastery of highly specialized procedures.

  15. Forgiveness Flexibility

    Directory of Open Access Journals (Sweden)

    Tuğba Seda Çolak

    2016-01-01

    Full Text Available Forgiveness flexibility is the skill to minimize the negative effect of an event by using cognitive, affective and behavioral skills while taking a stand at the end of an injurious process. A number of studies were conducted to test the flexibility of the structure of forgiveness. The theoretical structure, structural validity and the confirmatory factor analysis supported the theoretical structure of forgiveness flexibility. The criterion validity evaluated in similar manners was found high. Forgiveness flexibility designed as a three dimensional structure and its sub-dimensions was confirmed theoretically as the recognition of forgivenessand the internalization of forgiveness through insight and its practice.

  16. Discotic liquid crystals: a new generation of organic semiconductors.

    Science.gov (United States)

    Sergeyev, Sergey; Pisula, Wojciech; Geerts, Yves Henri

    2007-12-01

    Discotic (disc-like) molecules typically comprising a rigid aromatic core and flexible peripheral chains have been attracting growing interest because of their fundamental importance as model systems for the study of charge and energy transport and due to the possibilities of their application in organic electronic devices. This critical review covers various aspects of recent research on discotic liquid crystals, in particular, molecular design concepts, supramolecular structure, processing into ordered thin films and fabrication of electronic devices. The chemical structure of the conjugated core of discotic molecules governs, to a large extent, their intramolecular electronic properties. Variation of the peripheral flexible chains and of the aromatic core is decisive for the tuning of self-assembly in solution and in bulk. Supramolecular organization of discotic molecules can be effectively controlled by the choice of the processing methods. In particular, approaches to obtain suitable macroscopic orientations of columnar superstructures on surfaces, that is, planar uniaxial or homeotropic alignment, are discussed together with appropriate processing techniques. Finally, an overview of charge transport in discotic materials and their application in optoelectronic devices is given.

  17. Conflicting flexibility

    NARCIS (Netherlands)

    De Jong, P.; Schaap, A.

    2011-01-01

    New buildings are designed for first users. For a sustainable approach there are many advantages in designing in flexibility and adjustability in order to enable and facilitate the other sequential users. For the first investor this flexibility is translated into improved exit values due to

  18. Towards a new generation of pixel detector readout chips

    CERN Document Server

    Campbell, M; Ballabriga, R.; Frojdh, E.; Heijne, E.; Llopart, X.; Poikela, T.; Tlustos, L.; Valerio, P.; Wong, W.

    2016-01-01

    The Medipix3 Collaboration has broken new ground in spectroscopic X-ray imaging and in single particle detection and tracking. This paper will review briefly the performance and limitations of the present generation of pixel detector readout chips developed by the Collaboration. Through Silicon Via technology has the potential to provide a significant improvement in the tile- ability and more flexibility in the choice of readout architecture. This has been explored in the context of 3 projects with CEA-LETI using Medipix3 and Timepix3 wafers. The next generation of chips will aim to provide improved spectroscopic imaging performance at rates compatible with human CT. It will also aim to provide full spectroscopic images with unprecedented energy and spatial resolution. Some of the opportunities and challenges posed by moving to a more dense CMOS process will be discussed.

  19. Interdisciplinarity, a New Generation of Architects, and Mediocritas

    Directory of Open Access Journals (Sweden)

    Silvio Carta

    2016-12-01

    Full Text Available The discussion about the legitimacy of architecture being an autonomous discipline or a part of an interrelated system of areas of knowledge has been long discussed[i]. This article connects the scenario described by Fraser[ii] and Wigley[iii] where architecture needs to be considered in an expanded field as consequence of the post-critical period, to the work of a new generation of architects whose interest lies on questions that are peripheral to architecture sensu stricto. The type of architecture that emerges in this scenario is characterised by a proclivity towards other disciplines, including politics, economics and social studies. The article presents a series of examples of recent projects and discusses the impact of their approach to architecture. As a conclusion, this paper proposes the notion of mediocritas to establish a right balance between architecture as an autonomous discipline and its contamination with other cultural fields. [i]Bill Hillier, & Adrian Leaman, “Architecture as a discipline”. Journal of Architectural Research, 5(1, 28-32; Liane Lefaivre & Alexander Tzonis, “The Question of Autonomy in Architecture,” Harvard Architecture Review. vol. 3, 1984, pp. 25-42; Michael K. Hays, Oppositions reader (New York: Princeton Architectural Press, 1998. Peter Eisenman, “Autonomy and the Will to the Critical,” Assemblage. April 2000, issue 41; Piotrowski, A., & Robinson, J. W. (2001. The discipline of architecture. U of Minnesota Press; Hays, K. Michael and Lauren Kogod. “Twenty Projects at the Boundaries of the Architectural Discipline Examined in Relation to the Historical and Contemporary Debates over Autonomy,” Perspecta: The Yale Architectural Journal. vol. 33, 2002, pp 54-71.; Anderson, Stanford. “Quasi-Autonomy in Architecture: the Search for an InBetween,” Perspecta: The Yale Architectural Journal. vol. 33, 2002, pp. 30-37. [ii]Murray Fraser, “The cultural contest of critical architecture”, The

  20. EIGER: A new generation of computational electromagnetics tools

    Energy Technology Data Exchange (ETDEWEB)

    Wilton, D.R. [Houston Univ., TX (United States). Dept. of Electrical Engineering; Johnson, W.A.; Jorgenson, R.E. [Sandia National Labs., Albuquerque, NM (United States); Sharpe, R.M.; Grant, J.B. [Lawrence Livermore National Lab., CA (United States)

    1996-03-01

    The EIGER project (Electromagnetic Interactions GenERalized) endeavors to bring the next generation of spectral domain electromagnetic analysis tools to maturity and to cast them in a general form which is amenable to a variety of applications. The tools are written in Fortran 90 and with an object oriented philosophy to yield a package that is easily ported to a variety of platforms, simply maintained, and above all efficiently modified to address wide ranging applications. The modular development style and the choice of Fortran 90 is also driven by the desire to run efficiently on existing high performance computer platforms and to remain flexible for new architectures that are anticipated. The electromagnetic tool box consists of extremely accurate physics models for 2D and 3D electromagnetic scattering, radiation, and penetration problems. The models include surface and volume formulations for conductors and complex materials. In addition, realistic excitations and symmetries are incorporated, as well as, complex environments through the use of Green`s functions.

  1. Flexible Sigmoidoscopy

    Science.gov (United States)

    ... Task Force (USPSTF). Most doctors recommend colonoscopy to screen for colon cancer because colonoscopy shows the entire colon and can remove colon polyps. However, preparing for and performing a flexible sigmoidoscopy may take less time and you may ...

  2. New generation of airborne lidar for forest canopy sampling

    Science.gov (United States)

    Cuesta, J.; Chazette, P.; Allouis, T.; Sanak, J.; Genou, P.; Flamant, P. H.; Durrieu, S.; Toussaint, F.

    2009-04-01

    Cuesta J. (1,2), Chazette P. (1,3), Allouis T. (4), Sanak J. (1,3), Genau P. (2), Flamant P.H. (1), Durrieu S. (4) and Toussaint F. Biomass in forest cover is an essential actor in climate regulation. It is one of the principal sinks of atmospheric CO2 and a major water cycle regulator. In the coming years, climate change may generate an increase in the frequency of fires in the ecosystems, which are already affected in regions as southern Europe, near the Mediterranean basin. For a better understanding and prevention of the risks created by the propagation and intensity of fires, one requires a detailed characterization of the structural parameters of the forest canopy. Such description is as well essential for a proper management and sustainable use of forest resources and the characterization of the evolution of bio-diversity. These environmental and socio-economical issues motivate the development of new remote sensing instruments and methodology, particularly active remote sensing by lidar. These tools should be evaluated in order to achieve a global survey of the forest cover by satellite observation. In this framework, a French effort of the Institut Pierre Simon Laplace (LMD, LSCE and LATMOS) and the CEMAGREF has led to the deployment of a new airborne lidar prototype to study the vertical distribution of the forest canopy in the Landes region in France, around the Arcachon basin and Mimizan. The measuring system is the ultra-violet new generation lidar LAUVA (Lidar Aérosol UtraViolet (Aéroporté), Chazette et al., EST 2007), onboard an Ultra-Light Airplane (ULA). This system was developed by the Comissarait pour l'Energie Atomique and the Centre National de Recherches Scientifiques, originally for atmospheric applications, and it was successfully used in West Africa in the framework of the African Monsoon Multidisciplinary Analyses. After a proper adaptation, this compact and polyvalent lidar onboard an ULA is capable of measuring the forest canopy with

  3. Connotation and Characteristics of Employment Ability of New-generation Migrant Workers in China

    OpenAIRE

    Liu, Jun-wei; Cao, Yong-feng

    2012-01-01

    Based on China's special conditions and characteristics of specific group of new-generation migrant workers, this article researches connotation of employment ability of new-generation migrant workers in China, that is, the connotation of employment ability of new-generation migrant workers in China should include four aspects: professional knowledge and skills, learning capacity, adaptability and environmental force. On this basis, through the analysis of indicators concerning connotation of...

  4. A new generation of MEMS middle-infrared spectrometers

    Science.gov (United States)

    Otto, Thomas; Saupe, Ray; Stock, Volker; Seider, Thomas; Gessner, Thomas

    2014-03-01

    Mid infrared spectroscopy has been developed to a powerful and essential method of material analysis, with a steadily increasing number of industrial and scientific application fields. The so called spectral fingerprint range enables identification of chemical compounds by their unique spectral pattern. To provide a suitable miniaturized and portable MIR spectrometer solution at an affordable price, an existing MEMS NIR spectrometer module which already bases on micro system technology has been expanded in its wavelength range. The developed spectrometer belongs to the category of scanning grating spectrometers. Main component is a fast oscillating micro-mirror which moves sinusoidal with high mechanical precision enabling a high stability of according wavelength axis. This is supported by a highly precise optical tracking of the actual motion. Mono-crystalline silicon guarantees a long-life operation with no wear even under harsh environmental conditions. Spectral signal acquisition is realized by using a TE-cooled MCT single element detector assisted by low noise trans-impedance amplifier. With the help of integrated logic components a data pre-processing takes place, such as averaging, offset subtraction, detector transfer characteristic correction and noise shaping. Due the compact and flexible setup, the spectrometer is suitable for the use in various applications, such as process control in chemical industry, gas mixture analysis or liquid verification. The portability of the device opens up new application possibilities in mobile environment. The advances of the promising technology and its specific applications will be described in this paper. Advanced performance issues of the device be reviewed in detail.

  5. Alleviating the Collision States and Fleet Optimization by Introducing a New Generation of Automated Guided Vehicle Systems

    Directory of Open Access Journals (Sweden)

    Parham Azimi

    2011-01-01

    Full Text Available The aim of the current research is to propose a new generation of automated guided vehicle systems for alleviating the collision states in material handling systems where the automated guided vehicles movements are allowed to be both unidirectional and bidirectional. The objective function is to maximize the average annual profit in an FMS system using a simulation method. Despite several researches done in this field, this criterion has been studied rarely. The current study includes some new changes in AGV design for preventing some common problems such as congestions and deadlocks based on real profits/costs analysis in a flexible manufacturing system. For this reason, some experiments have been carried out to study the effects of several empty vehicle dispatching rules on average annual profit. The results show that the proposed framework is efficient and robust enough for industrial environments.

  6. Carbon nanotubes leading the way forward in new generation 3D tissue engineering.

    Science.gov (United States)

    Hopley, Erin Leigh; Salmasi, Shima; Kalaskar, Deepak M; Seifalian, Alexander M

    2014-01-01

    Statistics from the NHS Blood and Transplant Annual Review show that total organ transplants have increased to 4213 in 2012, while the number of people waiting to receive an organ rose to 7613 that same year. Human donors as the origin of transplanted organs no longer meet the ever-increasing demand, and so interest has shifted to synthetic organ genesis as a form of supply. This focus has given rise to new generation tissue and organ engineering, in the hope of one day designing 3D organs in vitro. While research in this field has been conducted for several decades, leading to the first synthetic trachea transplant in 2011, scaffold design for optimising complex tissue growth is still underexplored and underdeveloped. This is mostly the result of the complexity required in scaffolds, as they need to mimic the cells' native extracellular matrix. This is an intricate nanostructured environment that provides cells with physical and chemical stimuli for optimum cell attachment, proliferation and differentiation. Carbon nanotubes are a popular addition to synthetic scaffolds and have already begun to revolutionise regenerative medicine. Discovered in 1991, these are traditionally used in various areas of engineering and technology; however, due to their excellent mechanical, chemical and electrical properties their potential is now being explored in areas of drug delivery, in vivo biosensor application and tissue engineering. The incorporation of CNTs into polymer scaffolds displays a variety of structural and chemical enhancements, some of which include: increased scaffold strength and flexibility, improved biocompatibility, reduction in cancerous cell division, induction of angiogenesis, reduced thrombosis, and manipulation of gene expression in developing cells. Moreover CNTs' tensile properties open doors for dynamic scaffold design, while their thermal and electrical properties provide opportunities for the development of neural, bone and cardiac tissue constructs

  7. A new generation of cyberinfrastructure and data services for earth system science education and research

    Science.gov (United States)

    Ramamurthy, M. K.

    2006-06-01

    A revolution is underway in the role played by cyberinfrastructure and modern data services in the conduct of research and education. We live in an era of an unprecedented data volume from diverse sources, multidisciplinary analysis and synthesis, and active, learner-centered education emphasis. Complex environmental problems such as global change and water cycle transcend disciplinary and geographic boundaries, and their solution requires integrated earth system science approaches. Contemporary education strategies recommend adopting an Earth system science approach for teaching the geosciences, employing pedagogical techniques such as enquiry-based learning. The resulting transformation in geoscience education and research creates new opportunities for advancement and poses many challenges. The success of the scientific enterprise depends heavily on the availability of a state-of-the-art, robust, and flexible cyberinfrastructure, and on the timely access to quality data, products, and tools to process, manage, analyze, integrate, publish, and visualize those data. Concomittantly, rapid advances in computing, communication, and information technologies have revolutionized the provision and use of data, tools and services. The profound consequences of Moore's Law and the explosive growth of the Internet are well known. On the other hand, how other technological trends have shaped the development of data services is less well understood. For example, the advent of digital libraries, web services, open standards and protocols have been important factors in shaping a new generation of cyberinfrastructure for solving key scientific and educational problems. This paper presents a broad overview of these issues, along with a survey of key information technology trends, and discuses how those trends are enabling new approaches to applying data services for solving geoscientific problems.

  8. A new generation of cyberinfrastructure and data services for earth system science education and research

    Directory of Open Access Journals (Sweden)

    M. K. Ramamurthy

    2006-01-01

    Full Text Available A revolution is underway in the role played by cyberinfrastructure and modern data services in the conduct of research and education. We live in an era of an unprecedented data volume from diverse sources, multidisciplinary analysis and synthesis, and active, learner-centered education emphasis. Complex environmental problems such as global change and water cycle transcend disciplinary and geographic boundaries, and their solution requires integrated earth system science approaches. Contemporary education strategies recommend adopting an Earth system science approach for teaching the geosciences, employing pedagogical techniques such as enquiry-based learning. The resulting transformation in geoscience education and research creates new opportunities for advancement and poses many challenges. The success of the scientific enterprise depends heavily on the availability of a state-of-the-art, robust, and flexible cyberinfrastructure, and on the timely access to quality data, products, and tools to process, manage, analyze, integrate, publish, and visualize those data. Concomittantly, rapid advances in computing, communication, and information technologies have revolutionized the provision and use of data, tools and services. The profound consequences of Moore's Law and the explosive growth of the Internet are well known. On the other hand, how other technological trends have shaped the development of data services is less well understood. For example, the advent of digital libraries, web services, open standards and protocols have been important factors in shaping a new generation of cyberinfrastructure for solving key scientific and educational problems. This paper presents a broad overview of these issues, along with a survey of key information technology trends, and discuses how those trends are enabling new approaches to applying data services for solving geoscientific problems.

  9. The Analysis of New Generation Mobile Device Dependencies of Students in Faculty of Education

    Science.gov (United States)

    Korucu, Agah Tugrul; Usta, Ertugrul

    2016-01-01

    The development of technology brought about some advantages as well as particular disadvantages. Smart phones which are new generation mobile devices are technological tools for meeting certain needs such as entertainment, social media, realization of daily routines and usage for educational purposes. The facts that new generation mobile devices…

  10. 77 FR 76160 - New Generation Biofuels Holdings, Inc.; Order of Suspension of Trading

    Science.gov (United States)

    2012-12-26

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION New Generation Biofuels Holdings, Inc.; Order of Suspension of Trading December 21, 2012. It... concerning the securities of New Generation Biofuels Holdings, Inc. because it has not filed any periodic...

  11. Piping Flexibility

    Science.gov (United States)

    1978-01-01

    A NASA computer program aids Hudson Engineering Corporation, Houston, Texas, in the design and construction of huge petrochemical processing plants like the one shown, which is located at Ju'aymah, Saudi Arabia. The pipes handling the flow of chemicals are subject to a variety of stresses, such as weight and variations in pressure and temperature. Hudson Engineering uses a COSMIC piping flexibility analysis computer program to analyze stresses and unsure the necessary strength and flexibility of the pipes. This program helps the company realize substantial savings in reduced engineering time.

  12. Flexibility conflict?

    NARCIS (Netherlands)

    Delsen, L.W.M.

    2002-01-01

    The chapter deals with the presupposed conflict of interests between employers and employees resulting from a decoupling of operating hours and working times. It starts from the notion that both long operating hours and flexibility are relative concepts. As there is some discretion, the ultimate

  13. Flexible Consumption

    DEFF Research Database (Denmark)

    Holm Jacobsen, Peter; Pallesen, Trine

    This report presents the first findings from our qualitative study of consumer behaviour vis-à-vis flexible consumption. The main of objective of this report is to present our first round of data from Bornholm, and to assist the design of products/services designed in WP6. In the report, we adopt...

  14. Flexible isotopy classification of flexible links

    OpenAIRE

    Björklund, Johan

    2012-01-01

    In this paper we define and study flexible links and flexible isotopy in projective space. Flexible links are meant to capture the topological properties of real algebraic links. We classify all flexible links up to flexible isotopy using Ekholms interpretation of Viros encomplexed writhe.

  15. Flexible Capitalism

    DEFF Research Database (Denmark)

    Approaching “work” as at heart a practice of exchange, this volume explores sociality in work environments marked by the kind of structural changes that have come to define contemporary “flexible” capitalism. It introduces anthropological exchange theory to a wider readership, and shows how...... the perspective offers new ways to enquire about the flexible capitalism’s social dimensions. The essays contribute to a trans-disciplinary scholarship on contemporary economic practice and change by documenting how, across diverse settings, “gift-like” socialities proliferate, and even sustain the intensified...... flexible commoditization that more commonly is touted as tearing social relations apart. By interrogating a keenly debated contemporary work regime through an approach to sociality rooted in a rich and distinct anthropological legacy, the volume also makes a novel contribution to the anthropological...

  16. New-generation Migrant Workers’ Urban Adaptation: A Case Study of Jianggan District in Hangzhou City

    Institute of Scientific and Technical Information of China (English)

    Fei; SU; Bo; LI; Jianyi; HUANG; Zhimei; LI; Jiamiao; ZENG

    2015-01-01

    New-generation migrant workers are the " elite" among migrant workers,and whether they can really adapt to the city is one of the real problems to be urgently solved during China’s new urbanization,related to the success of new urbanization construction. From the perspective of livelihood capital,this paper uses the measuring indicators in line with the new-generation migrant workers’ livelihood characteristics,to analyze the typical characteristics and causes of new-generation migrant workers’ urban adaptation in Jianggan District of Hangzhou City based on field survey data. In the study,it is found that the new-generation migrant workers’ urban adaptation characteristics are focused on life adaptation,work adaptation and cultural adaptation,but the adaptation in the three areas is not good and there is a big room for improvement.

  17. THE SUBSTANTIATION OF THE CONCEPT OF A NEW GENERATION OF PHYSIOTHERAPEUTIC COMPLEXES

    Directory of Open Access Journals (Sweden)

    A. N. Osipov

    2012-01-01

    Full Text Available Concept of a new generation of physiotherapeutic complexes is analyzed. The requirements for the database for them are formulated. List of problems that should be addressed to create such complexes is given.

  18. Connotation and Characteristics of Employment Ability of New-generation Migrant Workers in China

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Based on China’s special conditions and characteristics of specific group of new-generation migrant workers,this article researches connotation of employment ability of new-generation migrant workers in China,that is,the connotation of employment ability of new-generation migrant workers in China should include four aspects:professional knowledge and skills,learning capacity,adaptability and environmental force.On this basis,through the analysis of indicators concerning connotation of employment ability,we get the overall characteristics of employment ability of new-generation migrant workers in China and reason responsible for its serious weakness.Finally we put forward corresponding countermeasures as follows:impart professional knowledge and skills;promote learning capacity;foster adaptive capacity;improve employment environment.

  19. Design acceptance summary report for the new generation transfer pump (NGTP)

    Energy Technology Data Exchange (ETDEWEB)

    IRONS, J.

    1999-10-27

    This report documents design review of the New Generation Transfer Pump versus the functions and requirements of the SY-101 Rapid Mitigation Project. Previously unpublished documentation for the pump is included in support of the design.

  20. Establishment of Comprehensive Evaluation Model of the New Generation Migrant Workers' Employability

    OpenAIRE

    GAO, Jianli; ZHANG, Tongquan

    2013-01-01

    Through literature research and expert interviews, we extract 10 variables influencing the new generation migrant workers' employability, and establish the comprehensive evaluation model of the new generation migrant workers' employability. Using factor analysis, we derive that the model includes three factors: skill literacy, relationship literacy and basic literacy. The weights of each factor are 0.580, 0.244 and 0.174 8, respectively. Skill literacy is affected by skill level, learning abi...

  1. Flexible Capitalism

    DEFF Research Database (Denmark)

    Approaching “work” as at heart a practice of exchange, this volume explores sociality in work environments marked by the kind of structural changes that have come to define contemporary “flexible” capitalism. It introduces anthropological exchange theory to a wider readership, and shows how...... the perspective offers new ways to enquire about the flexible capitalism’s social dimensions. The essays contribute to a trans-disciplinary scholarship on contemporary economic practice and change by documenting how, across diverse settings, “gift-like” socialities proliferate, and even sustain the intensified...

  2. Pneumatic lithotripsy through ureteroscope for treating ureteral calculi%输尿管镜气压弹道碎石术治疗输尿管结石

    Institute of Scientific and Technical Information of China (English)

    林飞鹤; 谢春发; 高海亮; 蔡伯基; 蔡道广

    2015-01-01

    Objective To evaluate the efficacy and safety of the pneumatic lithotripsy through ureteroscope for the treatment of ureteral calculi.Methods A total of 920 patients underwent ureteroscopic lithotripsy using pneu-matic lithotripsy 259 upper,375 middle,and 286 lower ureteral stone were treated.Results The overall successful fragmentation rate for all levels of ureteral stones in a single session achieved 94.0% (864 /920),failure rate 6.0%(56 /920).28 cases failed because of ureteral stricture.24 cases of stone moved up into the kidney.All worst -cases were in dewelled shock wave lithotripsy ESWL.Conclusion Ureteroscopic lithotripsy using pneumatic lithotripsy is a highly effective,minimally invasive and safe therapy for ureteral calculi.It is indicated as a first choice for treatment patients with ureteral stones,especially for the ones with the middle and lower uneteral stones.Develop particularly suitable for basic hospital.%目的:总结分析经尿道输尿管镜气压弹道碎石术治疗输尿管结石的疗效及其安全性。方法应用输尿管镜气压弹道碎石术治疗920例输尿管结石,其中输尿管上段结石259例,输尿管中段结石375例,输尿管下段结石286例。结果920例输尿管结石单次成功率94%(864/920),失败率6%(56/920)。失败原因:28例因输尿管口畸形狭窄而上镜失败,24例碎石过程中部分结石进入肾内,52例失败病例在留置双 J管条件下术后辅助冲击波体外碎石治疗。4例因既往有输尿管手术史或多次 ESWL 史,结石远端输尿管明显扭曲或狭窄,术中输尿管镜试图扩张通过而发生穿孔。结论输尿管镜气压弹道碎石术治疗输尿管结石有效,微创、安全、经济,是治疗输尿管结石特别是输尿管中、下段结石的首选治疗方法,特别适合在基层医院开展。

  3. Problems of New Generation Migrant Workers from the Perspective of Social Discrimination

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The correlation of migrant workers and other social problems are studied from the aspects of the concept of "migrant workers" and social discrimination,"new generation" and mobility of social class,and the gender structure of new generation migrant workers.The results show that the "worker" in the "migrant worker" comes from the "work for other people";although the "migrant worker" has the sense of discrimination,it really reflects the survival states of a certain social class;comparing with the first class migrant workers,the new generation migrant workers are the second generation of migrant workers,and their social position has not changed basically.The unfairness of social mobility is included among the "poor second generation","rich second generation" and "officer second generation",which may lead to the hardening of social class and the appear of opposite classes;the new generation migrant workers are subverting their fathers’ psychological recognition of "man dominates the outside and the woman dominates the inside" by the imbalanced sex structure,which is characterized by more women and less men.The social problems concerning new generation migrant workers caused by the sex discrepancy are directly related to the construction of the framework which comes up to the human moral and the stable improvement of the whole social ideological and cultural level.

  4. Establishment of Comprehensive Evaluation Model of the New Generation Migrant Workers’ Employability

    Institute of Scientific and Technical Information of China (English)

    Jianli; GAO; Tongquan; ZHANG

    2013-01-01

    Through literature research and expert interviews,we extract 10 variables influencing the new generation migrant workers’ employability,and establish the comprehensive evaluation model of the new generation migrant workers’ employability. Using factor analysis,we derive that the model includes three factors: skill literacy,relationship literacy and basic literacy. The weights of each factor are 0. 580,0. 244 and 0. 174 8,respectively. Skill literacy is affected by skill level,learning ability,career aspiration,ability to analyze problems,physical health status and other factors. Relationship literacy is affected by the sense of teamwork,interpersonal skills,social support and other factors. Basic literacy is affected by educational level,hardworking spirit and other factors. According to the results,we put forth the following recommendations to improve the new generation migrant workers’ employability: strengthening the vocational skill training; coordinating the vocational education resources.

  5. Flexible robotic retrograde renoscopy: description of novel robotic device and preliminary laboratory experience.

    Science.gov (United States)

    Desai, Mihir M; Aron, Monish; Gill, Inderbir S; Pascal-Haber, Georges; Ukimura, Osamu; Kaouk, Jihad H; Stahler, Gregory; Barbagli, Federico; Carlson, Christopher; Moll, Fredric

    2008-07-01

    To describe a novel flexible robotic system for performing retrograde intrarenal surgery. Remote robotic flexible ureterorenoscopy was performed bilaterally in 5 acute swine (10 kidneys). A novel 14F robotic catheter system, which manipulated a passive optical fiberscope mounted on a remote catheter manipulator was used. The technical feasibility, efficiency, and reproducibility of accessing all calices were assessed. Additionally, laser lithotripsy of calculi and laser ablation of renal papillae were performed. The robotic catheter system could be introduced de novo in eight ureters; two ureters required balloon dilation. The ureteroscope could be successfully manipulated remotely into 83 (98%) of the 85 calices. The time required to inspect all calices within a given kidney decreased with experience from 15 minutes in the first kidney to 49 seconds in the last (mean 4.6 minutes). On a visual analog scale (1, worst to 10, best), the reproducibility of caliceal access was rated at 8, and instrument tip stability was rated at 10. A renal pelvic perforation constituted the solitary complication. Histologic examination of the ureter showed changes consistent with acute dilation without areas of necrosis. A novel robotic catheter system is described for performing retrograde ureterorenoscopy. The potential advantages compared with conventional manual flexible ureterorenoscopy include an increased range of motion, instrument stability, and improved ergonomics. Ongoing refinement is likely to expand the role of this technology in retrograde intrarenal surgery in the near future.

  6. Meteorological input for atmospheric dispersion models: an inter-comparison between new generation models

    Energy Technology Data Exchange (ETDEWEB)

    Busillo, C.; Calastrini, F.; Gualtieri, G. [Lab. for Meteorol. and Environ. Modell. (LaMMA/CNR-IBIMET), Florence (Italy); Carpentieri, M.; Corti, A. [Dept. of Energetics, Univ. of Florence (Italy); Canepa, E. [INFM, Dept. of Physics, Univ. of Genoa (Italy)

    2004-07-01

    The behaviour of atmospheric dispersion models is strongly influenced by meteorological input, especially as far as new generation models are concerned. More sophisticated meteorological pre-processors require more extended and more reliable data. This is true in particular when short-term simulations are performed, while in long-term modelling detailed data are less important. In Europe no meteorological standards exist about data, therefore testing and evaluating the results of new generation dispersion models is particularly important in order to obtain information on reliability of model predictions. (orig.)

  7. Treatment of lower urethral calculi with extracorporeal shock-wave lithotripsy and pneumatic ureteroscopic lithotripsy: a comparison of effectiveness and complications

    Institute of Scientific and Technical Information of China (English)

    钟惟德; 曾广翘; 蔡岳斌; 戴奇山; 胡建波; 魏鸿蔼

    2003-01-01

    Objective To determine the efficacy and incidence of complications of extracorporeal shock-wave lithotripsy (ESWL) compared with pneumatic ureteroscopic lithotripsy (URSL) in the treatment of lower uretheral calculi. Methods From August 1997 to June 1999, 210 patients with lower ureteric calculi were treated with ESWL and the other 180 with URSL. The stones were fragmented with pneumatic lithotripter. The outcome was assessed by evacuation, retreatment and complication rates.Results ESWL for lower ureteric calculi resulted in a stone evacuation rate of 78.1%, compared with 93.3% for URSL (P<0.05). ESWL had a retreatment rate of 11.9% and a perforation rate of 0, while URSL caused perforation of ureters in 3.3% of patients and a refreatment of 2.2%. Conclusion For the management of lower ureteric calculi, ESWL provides a non-invasive, simple and safe option, and URSL has a higher stone evacuation rate but causes ureter perforation more frequently than ESWL does. Both ESWL and URSL have their respective advantages. It is recommended, however, that URSL be extensively developed for better treatment efficacy, given that the operator has an adequate technical background.

  8. Stress distribution of new generation of Twisted Files in comparison with ProTaper: A finite element analysis

    Directory of Open Access Journals (Sweden)

    Harsha Pujari

    2013-01-01

    Full Text Available Aim: To compare and evaluate the stress distribution of new generation of Twisted File in comparison with ProTaper under bending or torsional conditions using a finite - element analysis model. Materials and Methods: Two NiTi files, a ProTaper file and the latest generation nickel titanium file which is the Twisted File of similar tip diameter were scanned using White light scanning system. Through this a real size digitized models of the two brands of NiTi instruments were obtained. Then, the outline of the instrument was extracted from the stacks of 3D data in software. Finally a mesh of linear, eight-noded, hexahedral elements was overlaid onto the rendered 3D image. The behavior of the instrument under bending or torsional loads was then analyzed mathematically in the software (ABAQUS V6, 5-1 taking into consideration the non linear mechanical characteristic of NiTi material. The results were expressed as von Mises stresses and were calculated by the von Mises criteria. Results: Higher stress values were seen in Twisted Files than the ProTaper universal, however, the angular deflection was seen to be more in Twisted Files. Conclusion: As more angular deflection was seen in Twisted File it was more flexible than ProTaper Universal but did not have the uniform stress distribution like the ProTaper universal.

  9. Transcatheter Aortic Valve Replacement With Early- and New-Generation Devices in Bicuspid Aortic Valve Stenosis

    DEFF Research Database (Denmark)

    Yoon, Sung-Han; Lefèvre, Thierry; Ahn, Jung-Ming

    2016-01-01

    BACKGROUND: Few studies have evaluated the clinical outcomes of transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic valve stenosis (AS). Particularly, limited data exist comparing the results of TAVR with new-generation devices versus early-generation devices. OBJECTIVE...

  10. The PPTN-02 new-generation current-voltage transducers for measuring of photosignals

    Directory of Open Access Journals (Sweden)

    Butenko V. K.

    2008-02-01

    Full Text Available The measurement results of technical characteristics of new-generation current-voltage transducers which have low input resistance (<10 Оhm and providing ptotodiodes photocurrent measurement from 1·10-12 to 1·10-3 A are presented.

  11. Employment Will of New Generation Migrant Workers in Hubei Province and Countermeasures

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    The issue concerning new generation migrant workers is an important part of current social management. How to improve employment ability of new generation migrant workers is the central part of improving living of migrant workers and development environment. Based on survey data of 6 counties in Hubei Province,I analyzed employment will and influence factors of new generation migrant workers. Researches have indicated that going out to work,employment opportunity,nature of subordinate service industry,industrial technical level,and financial support play a significant role in employment intention of migrant workers,while their employment ability is influenced by their cultural quality,professional skills, working endurance,degree of policy cognition,and information channel,etc. In view of these five aspects,I put forward following countermeasures: raise educational level,improve skills,strengthen endurance,enhance attention to policies,and expand information channel,to improve employment ability of new generation migrant workers.

  12. A new generative complexity science of learning for a complex pedagogy

    NARCIS (Netherlands)

    Jörg, T.

    2007-01-01

    Proposal for the SIG Chaos and Complexity Theories at AERA 2007 Title: A New Generative Complexity Science of Learning for a Complex Pedagogy Ton Jörg IVLOS Institute of Education University of Utrecht The Netherlands A.G.D.Jorg@ivlos.uu.nl Introduction My paper focuses on the link between thinking

  13. How the New Generation of Well-Wired Multitaskers Is Changing Campus Culture

    Science.gov (United States)

    Chronicle of Higher Education, 2007

    2007-01-01

    This article presents a panel discussion at an interactive session at The Chronicle's Technology Forum which sought to explore how new generation of students change the image of campus culture. Richard T. Sweeney, university librarian at the New Jersey Institute of Technology (and the father of two Millennials as well as four other children),…

  14. Technical characteristics of new generation of nuclear power plants; Charakterystyka techniczna elektrowni jadrowych nowej generacji

    Energy Technology Data Exchange (ETDEWEB)

    Janczak, R.; Mikulski, A.; Staron, E. [Instytut Energii Atomowej, Swierk-Otwock (Poland)

    1997-12-31

    The concept of Advanced Light Water Reactors (ALWR) as a new generation of nuclear reactors for energetics have been presented. The influence of reactor accidents (TMI and Chernobyl) on technical and scientific development of nuclear reactors has been discussed from the view point of safety assurance and requirements being defined by American and European Nuclear Regulatory commission. 12 refs, 14 figs.

  15. The use of New Generation H1 Receptor Blockers and Advantages in Terms of Reliability

    Directory of Open Access Journals (Sweden)

    Muhammed Yayla

    2013-10-01

    Full Text Available H1 receptor blockers are one of the most commonly prescribed medications in the treatment of allergic disorders. These disease have reduced life quality of people and prevalent in the world. H1 receptor blockers has been used since 1940 and lead to some adverse effects such as sedation because of their chemical and pharmacological properties. Therefore new generations have been studied for reduced their adverse effect. The aims of this review are to exhibit advantages of new produced H1 receptor blockers compared to classical antihistamines and demonstrate efficacies of clinical uses of new produced H1 antihistamines. New generation H1 receptor blockers which have been developed after 1980s has less lipophilic properties and their sedative effects are minimized compared to classical antihistamines. Also, their specificity, affinity for H1 receptors and antihistaminergic effects are higher than classical H1 receptor blockers. Although new generation H1 receptor blockers are better tolerated than classical H1 receptor blockers, some of them lead to potential cardio toxicity. Consequently new generation H1 receptor blockers are reliable and efficient drugs, they provide convenience in the treatment of allergic disorders and prevent development of phobia against drugs.

  16. Results from multipoint alignment monitoring using the new generation of amorphous silicon position detectors

    Energy Technology Data Exchange (ETDEWEB)

    Alberdi, J.; Arce, P.; Barcala, J.M.; Calvo, E. [CIEMAT, 28040 Madrid (Spain); Ferrando, A. [CIEMAT, 28040 Madrid (Spain)], E-mail: antonio.ferrando@ciemat.es; Josa, M.I.; Molinero, A.; Navarrete, J.; Oller, J.C.; Yuste, C. [CIEMAT, 28040 Madrid (Spain); Calderon, A.; Gomez, G.; Gonzalez-Sanchez, F.J.; Martinez-Rivero, C.; Matorras, F.; Rodrigo, T.; Ruiz-Arbol, P.; Sobron, M.; Vila, I.; Virto, A.L. [Instituto de Fisica de Cantabria (IFCA), CSIC-University of Cantabria Santander (Spain)] (and others)

    2008-08-11

    We present the measured performance of a new generation of large sensitive area (28x28 mm{sup 2}) semitransparent amorphous silicon position detector sensors. More than 100 units have been characterized. They show a very high performance. To illustrate a multipoint application, we present results from the monitoring of five sensors placed in a 5.5-m-long light path.

  17. A new generative complexity science of learning for a complex pedagogy

    NARCIS (Netherlands)

    Jörg, T.

    2007-01-01

    Proposal for the SIG Chaos and Complexity Theories at AERA 2007 Title: A New Generative Complexity Science of Learning for a Complex Pedagogy Ton Jörg IVLOS Institute of Education University of Utrecht The Netherlands A.G.D.Jorg@ivlos.uu.nl Introduction My paper focuses on the link between thinking

  18. Flexible Electronics Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Flexible Electronics Research Facility designs, synthesizes, tests, and fabricates materials and devices compatible with flexible substrates for Army information...

  19. Analysis on Vocational Education and Social Mobility of New Generation Migrant Workers:A Case Study of Shijiazhuang City

    Institute of Scientific and Technical Information of China (English)

    Hongyan; LIU

    2013-01-01

    Based on survey data of current situations of new generation migrant workers vocational education and its influence on social mobility in Shijiazhuang City, the author believes that there are many drawbacks in vocational education of new generation migrant workers, including low participationt and varied training environment of enterprises. In addition, the influence of vocational education of migrant workers on social mobility is not very satisfactory. Finally, it presents countermeasures for improving vocational education, to promote social mobility of new generation migrant workers.

  20. Establishment of Indication System for Evaluating the Citizenization Level of New Generation Migrant Workers and Its Application

    Institute of Scientific and Technical Information of China (English)

    Jia; LU

    2015-01-01

    Scientific and reasonable indicator system is the key for evaluating citizenization level of new generation migrant workers. With reference to basic connotation of endogenous and exogenous variables and in view of citizenization characteristics of new generation migrant workers,it built an evaluation indicator system including endogenous indicators based on micro-individual and exogenous indicators based on mesourban environment and macro-national policies. Besides,combining current situation of new generation migrant workers in Jiangsu Province,it evaluated citizenization level of the indicator system,in the hope of providing certain reference for evaluating citizenization level of new generation migrant workers.

  1. High-grade ureteroscopic biopsy is associated with advanced pathology of upper-tract urothelial carcinoma tumors at definitive surgical resection.

    Science.gov (United States)

    Clements, Thomas; Messer, Jamie C; Terrell, John D; Herman, Michael P; Ng, Casey K; Scherr, Douglas S; Scoll, Benjamin; Boorjian, Stephen A; Uzzo, Robert G; Wille, Mark; Eggener, Scott E; Lucas, Steven M; Lotan, Yair; Shariat, Shahrokh F; Raman, Jay D

    2012-04-01

    Accurate assessment of upper-tract urothelial carcinoma (UTUC) pathology may guide use of endoscopic vs extirpative therapy. We present a multi-institutional cohort of patients with UTUC who underwent surgical resection to characterize the association of ureteroscopic (URS) biopsy features with final pathology results. URS biopsy data were available in 238 patients who underwent surgical resection of UTUC. Biopsies were performed using a brush biopsy kit, mechanical biopsy device, or basket. Stage was classified as a positive brush, nonmuscle-invasive (biopsy, 88/238 (37%) patients had a positive brush, 140 (59%) had a diagnosis of non-MI, and 10 (4%) had MI disease. Biopsy results showed low-grade cancer in 140 (59%) and high-grade cancer in 98 (41%). Pathologic evaluation at surgical resection demonstrated non-MI tumors in 140 (59%) patients, MI in 98 (41%), and high-grade disease in 150 (63%). On univariate analysis, high URS biopsy grade was associated with high-grade (positive predictive value [PPV] 92%, Pbiopsy stage, however, was associated with surgical pathology grade (P=0.005), but not MI (P=0.16) disease. On multivariate analysis, high URS grade, but not biopsy stage, was associated with high final pathology grade (hazard ratio [HR] 16.6, 95% confidence interval [CI] 7.0-39.5, Pbiopsy grade, but not stage, is associated with adverse tumor pathology. This information may play a valuable role for risk stratification and in the appropriate selection of endoscopic management vs surgical extirpation for UTUC.

  2. Novel mechanism of network protection against the new generation of cyber attacks

    Science.gov (United States)

    Milovanov, Alexander; Bukshpun, Leonid; Pradhan, Ranjit

    2012-06-01

    A new intelligent mechanism is presented to protect networks against the new generation of cyber attacks. This mechanism integrates TCP/UDP/IP protocol stack protection and attacker/intruder deception to eliminate existing TCP/UDP/IP protocol stack vulnerabilities. It allows to detect currently undetectable, highly distributed, low-frequency attacks such as distributed denial-of-service (DDoS) attacks, coordinated attacks, botnet, and stealth network reconnaissance. The mechanism also allows insulating attacker/intruder from the network and redirecting the attack to a simulated network acting as a decoy. As a result, network security personnel gain sufficient time to defend the network and collect the attack information. The presented approach can be incorporated into wireless or wired networks that require protection against known and the new generation of cyber attacks.

  3. On designing a control system for a new generation of accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Schaller, S.C.; Schultz, D.E.

    1987-01-01

    A well-conceived plan of attack is essential to the task of designing a control system for a large accelerator. Several aspects of such a plan have been investigated during recent work at LAMPF on design strategies for an Advanced Hadron Facility control system. Aspects discussed in this paper include: identification of requirements, creation and enforcement of standards, interaction with users, consideration of commercial controls products, integration with existing control systems, planning for continual change, and establishment of design reviews. We emphasize the need for the controls group to acquire and integrate accelerator design information from the start of the design process. We suggest that a controls design for a new generation of accelerators be done with a new generation of software tools. 12 refs.

  4. R&D on wireless broadband communication systems: new generation ubiquitous mobile network

    Science.gov (United States)

    Ogawa, Hiroyo

    2007-09-01

    R&D on new generation mobile network has attracted a growing interest over the world on the background of rapid market growth for 2nd and 3rd - generation cellular networks and wireless LANs/MANs. The National Institute of Information and Communications Technology (NICT) has been carried out the New Generation Mobile Network Project from April 2002 to March 2006, and has developed fundamental technologies to enable seamless and secure integration of various wireless access networks such as existing cellular networks, wireless LANs, home networks, intelligent transport systems (ITS), the Beyond-3G (B3G) cellular and other wireless access systems. From April 2006, Ubiquitous Mobile Network project focused on cognitive radio technology and integrated seamless networking technology was started. This paper overviews the achievement and the future plan of these projects.

  5. Beam characteristics of a new generation 50 MeV racetrack microtron.

    Science.gov (United States)

    Masterson, M E; Chui, C S; Febo, R; Hung, J D; Fuks, Z; Mohan, R; Ling, C C; Kutcher, G J; Bjork, S; Enstrom, J

    1995-06-01

    The first of a new generation of microtron accelerators has been installed and tested. It is currently in use for multisegment conformal radiotherapy at our institution. The unit produces x rays and electrons from 10 to 50 MeV in 5 MeV increments. It incorporates a 64 leaf, doubly focused multileaf collimator (MLC), which can be used to shape x-ray and electron beams. Both x-ray and electron beams are produced by magnetically scanning the electron beams from the accelerator. The new generation unit incorporates a purging magnet to sweep away any primary or secondary electrons that pass through the target(s). In this paper, the beam characteristics of the accelerator that were studied during acceptance testing are described. Representative examples of depth doses, beam profiles, output factors, and elementary beam distributions are presented and discussed, in comparison with the earlier generation of microtron accelerators and with other radiotherapy machines.

  6. Complications after implantation of a new-generation insertable cardiac monitor

    DEFF Research Database (Denmark)

    Diederichsen, Søren Zöga; Haugan, Ketil Jørgen; Højberg, Søren

    2017-01-01

    BACKGROUND: Insertable cardiac monitors (ICM) are leadless devices utilized in long-term monitoring of the heart rhythm. The implantation procedure of the new-generation ICMs is minimally invasive, but little experience exists regarding complications. We thus aimed to investigate adverse events (AE......) according to procedure-related characteristics after implantation of a large number of new-generation ICMs. METHODS: The study population consisted of participants randomized to receive ICM in a multi-center trial. The Reveal LINQ™ ICM was implanted using provided insertion tools, either....... In the 38 patients requiring device repositioning, more AEs requiring explantation were seen (3 (7.9%) vs. 6 (0.4%), p=0.001). Patients undergoing implantation in a procedure room had more infections (12 (1.6%) vs. 1 (0.1%), p=0.004), though no significant difference was reached in AEs requiring...

  7. Entice, engage, endure: adapting evidence-based retention strategies to a new generation of nurses

    OpenAIRE

    Broom, Catherine

    2010-01-01

    Catherine BroomCatherine Broom Consulting LLC, Lake Forest Park, WA, USAAbstract: Across the globe, the prolonged and expanding nursing shortage threatens dire consequences unless health care leaders can develop successful strategies to entice and engage a new generation of nurses. Over the past 3 decades investigational work regarding workforce attributes and the impact of organizational structures and processes has helped define professional nursing environments that successfully attract, s...

  8. Role of structural noise in aircraft pressure cockpit from vibration action of new-generation engines

    Science.gov (United States)

    Baklanov, V. S.

    2016-07-01

    The evolution of new-generation aircraft engines is transitioning from a bypass ratio of 4-6 to an increased ratio of 8-12. This is leading to substantial broadening of the vibration spectrum of engines with a shift to the low-frequency range due to decreased rotation speed of the fan rotor, in turn requiring new solutions to decrease structural noise from engine vibrations to ensure comfort in the cockpits and cabins of aircraft.

  9. Promotion of Intrinsic Motivation of New Generation Learners for Learning Physics by Digital Physics Labs

    OpenAIRE

    Peciuliauskiene, Palmira

    2015-01-01

    The article deals with the role of digital Physics experiments in the promotion of intrinsic motivation of secondary school age learners for learning Physics. The methodological basis of research is inquiry-based learning. The article focuses on the second level of inquiry-based learning referred to as structured inquiry. The study is based on the sociological approach, with the emphasis on the new generation (Generation Z) and their exclusive relationship to technology. The research problem ...

  10. The new generation of ABB's high energy batteries

    Energy Technology Data Exchange (ETDEWEB)

    Hartkopf, T. (ABB Hochenergiebatterie GmbH, Heidelberg (Germany)); Birnbreier, H. (ABB Hochenergiebatterie GmbH, Heidelberg (Germany))

    1992-01-01

    ABB have developed a new generation of high energy batteries using an improved cell design and a compact thermal enclosure Energy densities of more than 100 Wh/kg have been achieved. The production programme includes two standard batteries with 9,6 or 19.2 kWh energy content. Additional 6 different sizes of customers designed batteries have been built with energies up to 38 kWh in one bloc. (orig.)

  11. Adaptive Control and Multi-agent Interface for Infotelecommunication Systems of New Generation

    OpenAIRE

    Timofeev, Adil

    2004-01-01

    Problems for intellectualisation for man-machine interface and methods of self-organization for network control in multi-agent infotelecommunication systems have been discussed. Architecture and principles for construction of network and neural agents for telecommunication systems of new generation have been suggested. Methods for adaptive and multi-agent routing for information flows by requests of external agents- users of global telecommunication systems and computer network...

  12. Vacuum extraction: a randomized controlled comparison of the New Generation cup with the original Bird cup.

    Science.gov (United States)

    Carmody, F; Grant, A; Somchiwong, M

    1986-01-01

    A new design of vacuum extractor cup--'the New Generation cup'--has recently been introduced into clinical practice. Its major modification is a traction cord which passes around the rim of the cup for 180 degrees and is free to slide within the rim. Claims that this design 'enables the operator to pull obliquely without causing the cup to tilt' and thereby 'reduces failure rates, reduces the incidence of scalp trauma and increases operator confidence' have been evaluated in a randomized controlled trial. 123 women with singleton pregnancies of 37 completed weeks or more, with a cephalic presentation and for whom a decision to deliver by vacuum extraction had been taken, were randomly allocated to the 'New Generation' cup or BIRD's original vacuum extractor cup; 50 mm anterior and posterior cups were used in both groups as appropriate. The two groups were comparable at entry and delivered by obstetricians of similar status. The two types of cup were similar in respect of number of failures to deliver with the vacuum extractor, correct positioning of the cup, number of pulls required for delivery and time taken to expedite delivery. Cup detachments occurred in nine cases allocated to the 'New Generation' cup compared with four allocated to the original BIRD cup. The babies in the two groups were in similar condition at birth and sustained similar amounts of scalp trauma. Neonatal jaundice, both clinical and biochemical, was more common in babies delivered with the 'New Generation cup' and this was reflected in greater use of phototherapy in this group. Operators were equally divided in their preference of cup.(ABSTRACT TRUNCATED AT 250 WORDS)

  13. The Royal Navy’s New-Generation Type 45 Destroyer. Acquisition Options and Implications

    Science.gov (United States)

    2002-01-01

    Future Offshore Patrol Vessel FPSO Floating Production, Storage and Offloading vessel xxiii xxiv The Royal Navy’s New-Generation Type 45 Destroyer FSC...the conversion of a Floating Production, Storage and Offloading ( FPSO ) vessel, and a naval order for two Alternative Landing Ships Logistics (ALSL...Frigates, various Marine (OPVs) for Royal Brunei design work Navy Offshore SupplyVessel, ALSL, Landing Craft Utility, miscellaneous module and Auxiliary

  14. New Generation Discovery: A Systematic View for Its Development, Issues and Future

    KAUST Repository

    Yu, Yi

    2012-11-01

    Collecting, storing, discovering, and locating are integral parts of the composition of the library. To fully utilize the library and achieve its ultimate value, the construction and production of discovery has always been a central part of the library’s practice and identity. That is the reason why the new generation (also called the next-generation discovery) discovery gets such striking effect since it came into library automation arena. However, when we talk about the new generation of discovery in the library domain, we should see it in the entirety of the library as one of its organic parts and consider its progress along with the evolution of the whole library world. We should have a deeper understanding about its relationship and interaction with the internet, the rapidly changing digital environment, and the elements and the chain of library services. To address above issues, this paper overviews the different versions of the definition for the new generation discovery by combining our own understanding. The paper also gives our own description for its properties and characteristics. The paper points out what challenges, which extends the technology domain to commercial interests and business strategy, are faced by the discovery applications, and how library and library professionals deal with those challenges. Finally, the paper elaborates on the promise brought by the new discovery development and what the next exploration might be for its future.

  15. Analysis of Public Goods Supply of New Generation Migrant Workers’ Urban and Rural Double Marginalization

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Status quo of urban and rural public goods supply in China is analyzed.Firstly,public goods supply in rural areas is inadequate,for example,inadequate supply of agricultural infrastructure,lack of expenditure in agricultural science and technology,problems of rural drinking water safety,problems of rural roads and transportation,low levels of health care,weak rural public culture,short supply of farmers’ education.Secondly,the system and level of urban public goods provision can’t meet migrant workers’ demand,for example,less migrant workers are employed by the governments’ direction;migrant workers are isolated by urban housing project and these workers have difficulty in receiving city social security.One reason of new generation migrant workers facing the double marginalization of rural and urban crisis is that urban and rural public goods supply are different in particular the inadequate supply of public goods in rural areas.Three countermeasures are put forward in order to relieve new generation migrant workers’ double marginalization of urban and rural,which include increasing financial input in rural areas in order to achieve equalization of urban and rural public goods,perfecting the preferential agricultural policy to increase rural public goods supply,making urban public goods supply as a guide to promote the new generation migrant workers into the city.

  16. A NEW GENERATING METHOD FOR THE MACHINING OF A CYLINDRICAL GEAR WITH SYMMETRIC ARCUATE TOOTH TRACE

    Institute of Scientific and Technical Information of China (English)

    马振群; 龚堰珏; 王小椿

    2004-01-01

    Objective To introduce a new generating method for the machining of a cylindrical gear with symmetric arcuate tooth trace. Methods Adopting this method, the key problems of mismatch control and manufacturing of symmetric arcuate tooth trace gears are solved by using suitable cutter tilt and a new generating method with double-edge gear-wheel cutter. The machining principle is analyzed and the mathematical model of generating motion is established. Then the tooth flank equation and differential geometrical parameters are discussed. Results The minim alteration of cutter tilt will make the contact flank area change so as to satisfy the special requirements. It is easy to realize the tip relief of gearing by altering coefficients of every moving axis. Because the tooth has the arc shape, the symmetrical arcuate cylindrical gears have higher overall strength and it is easy to perform the flank grinding for high precision. Conclusion This new generating method has higher productivity. It is easy to get a perfect contact zone and fully give play to the potential bearing capacity of the gears. The symmetrical arcuate cylindrical gears can be used in highly durable and heavy duty gearing applications.

  17. Balance and flexibility.

    Science.gov (United States)

    2003-12-01

    The 'work-life balance' and flexible working are currently key buzz terms in the NHS. Those looking for more information on these topics should visit Flexibility at www.flexibility.co.uk for a host of resources designed to support new ways of working, including information on flexible workers and flexible rostering, the legal balancing act for work-life balance and home working.

  18. Clinical use of new-generation pulse oximeters in the neonatal intensive care unit.

    Science.gov (United States)

    Workie, Fegegta A; Rais-Bahrami, K; Short, Billie L

    2005-10-01

    Continuous monitoring by pulse oximetry is a common practice for preterm and critically ill newborns. A new generation of motion-tolerant pulse oximeters have been designed for improved clinical performance with a substantial reduction in alarm frequency. However, little is known about the differences among these new-generation pulse oximeters in the neonatal intensive care unit (NICU). The purpose of this study is to assess the clinical performance of two new-generation pulse oximeters in the NICU. Two new-generation pulse oximeters were used simultaneously to monitor 36 patients in the NICU. The two devices studied were the Philips FAST and the Masimo SET. Patients were randomly assigned for their digit selection and data were collected only when waveforms were of good quality and/or the pulse oximeter's pulse rate (PR) correlated with the electrocardiogram heart rate (HR). The data for oxygen saturation measurements, number of true and false alarms, and number of dropouts as well as the duration of dropouts for each pulse oximeter were recorded by the primary investigator at 5-minute intervals for a period of 2 hours on each patient. Dropouts are instances when the pulse oximeter alarm sounds due to its inability to identify the arterial pulse and provide an oxygen saturation reading. The mean gestational age for the study group was 32 weeks (rang, 24 to 42 weeks). Repeated-measures analysis of variance indicated no difference between the two devices across all time measurements (p=0.357). In addition, paired t-tests for true alarms and false alarms were not significant, with p-values of 0.151 and 0.869, respectively. There was a difference in the number of data dropouts (pMasimo 38). The duration of dropouts was also significant; the Philips device had three times longer duration of dropouts. Physiologic monitoring in the critical care setting requires accurate data measurements. The two new-generation pulse oximeters, the Philips FAST and Masimo SET, are

  19. Usability and printing technology: Ergonomic design of a new generation of web offset printing machines; Usability und Drucktechnik: Ergonomische Gestaltung einer neuen Generation von Rollendruckmaschinen

    Energy Technology Data Exchange (ETDEWEB)

    Enke, G. [MAN Roland Druckmaschinen AG, Augsburg (Germany)

    2002-07-01

    This paper describes the development of a user interface design of a new generation of a digital web offset printing machine, which integrates the whole printing workflow from prepress to postpress. The features of this highly complex printing machine DICOweb and the development of its user interface are presented. The operator was in the center of interest for designing the user interface. The DICOweb user interface allows easy operating and presents a clearly arranged view of the process and current operating status, without needing high initial periods of the operators. To guarantee a high flexibility and direct operation of the machine, a touchscreen user interface was applied. The screen design of the touchscreen requires a special style-guide. (orig.)

  20. Ureteroscope pneumatic lithotripsy for 204 cases of ureteral calculi%输尿管镜气压弹道碎石术治疗输尿管结石204例效果观察及治疗策略

    Institute of Scientific and Technical Information of China (English)

    张力; 胡兴平; 王凯

    2012-01-01

    Objective To investigate the effect of ureteroscope pneumatic lithotripsy for ureteral calculi. Methods Pneumatic lithotripsy under ureteroscopy was used to treat 204 cases of ureteral calculi, including 16 cases (8% ) in middle ureter and 188 cases (92% ) in lower ureter, in which 6 cases were in the wall of urinary bladder. Results The operation time varied from 15 to 116 min (45 min on average). The success rate of ureteroscope pneumatic lithotripsy was 98.0% (200 cases). The intraoperative stone free rate was 96. 6%. Stones in 2 cases transferred to kidney. Thus the surgery ended in failure. Some stones in 3 cases transferred to kidney after ureteroscope pneumatic lithotripsy (diameterIS3 mm). Stones in 1 case were exceptionally hard which could not be shattered by pneumatic lithotripsy probe and transferred to surgery. In another case, due to severe local mucosal edema with hemorrhage caused by swelling in the opening of the wall of urinary bladder, we could not find the front opening of ureter and insert a guide wire into it. This case was then cured by both surgery and ureteroscope pneumatic lithotripsy. Postoperative hematuria was observed by naked eye or microscope in all the cases, and disappeared 2-3 days after operation. No complications such as perforation and infection were found in any cases. Conclusions Ureteroscope pneumatic lithotripsy for ureteral calculi is effective, safe, with small damage of tissue, fewer complications, which can be used as the top choice for ureteral calculi in middle and lower ureter.%目的 观察输尿管镜气压弹道碎石术治疗输尿管结石的效果.方法 应用输尿管镜下气压弹道碎石治疗输尿管结石204例,其中输尿管中段结石16例(占8%),输尿管下段结石188例(占92%),膀胱壁内段结石6例.结果 204例手术时间15 ~116分钟,平均45分钟;碎石成功率98.0%(200例),术中结石排净率96.6%,2例结石漂移至肾脏,未能完成手术;3例碎石后,

  1. Future's operation areas: new-generation suppression enemy air defence (SEAD) elements

    Science.gov (United States)

    Hazinedar, Ä.°lker

    2015-05-01

    Since air vehicles took place in the theater of operations, they have become the indispensable elements and the strongest attack power of armed forces. In the following period, with technological development, supersonic aircrafts took place in the operation area and this increased effectiveness of air vehicles much more. Air forces have used these aircrafts during important missions like strategic attack and air defense operations. On the other hand, decision makers understood that it was not feasible to intercept fighter aircrafts by executing combat air patrol flight missions. Since there is not enough reaction time to intercept the high speed aircrafts, ground stationed Surface to Air Missiles (SAM) system requirement has emerged. Therefore, SAM systems took place in the operation scene as well. Due to the fact that SAM systems emerged against the attack power, the attack aircrafts are to keep away from the fire of the ground stationed SAM systems. Hence, the requirement of Suppression Enemy Air Defense (SEAD) arose. SEAD elements take under suppression the radar of the SAM systems. In this way, attack aircrafts are able to attack without the risk of SAM systems. The purpose of this study is to find new methods or concepts in order to protect friendly attack aircrafts against ground based surface to air missiles' fires. Modernization of SAM systems and new generation SAM system producing activities have proceeded with positive acceleration. So, current SEAD elements and concepts are not able to cover the requirements due to the increased SAM system ranges. According to the concepts, SEAD weapons` ranges must be longer than the SAM weapons' ranges to protect friendly aircrafts. In this study, new concept was offered to overcome the deficiencies of current SEAD concept. The elements of new concepts were put forward. Classic SEAD concept and new generation concepts were assessed by using SWOT analysis technique. As a result, this study has revealed that, air forces

  2. Development of a new generation gravity map of Antarctica: ADGRAV Antarctic Digital Gravity Synthesis

    Directory of Open Access Journals (Sweden)

    R. A. Arko

    1999-06-01

    Full Text Available The U.S. National Science Foundation (NSF has agreed to support the development of a new generation gravity map of Antarctica (ADGRAV - Antarctic Digital Gravity Synthesis, funding the development of a web based access tool. The goal of this project is the creation of an on-line Antarctic gravity database which will facilitate access to improved high resolution satellite gravity models, in conjunction with shipboard, airborne, and land based gravity measurements for the continental regions. This database will complement parallel projects underway to develop new continental bedrock (BEDMAP and magnetic (ADMAP maps of Antarctica.

  3. Web-based ERP systems: the new generation : case study: mySAP ERP

    OpenAIRE

    Gomis, Marie-Joseph

    2007-01-01

    With the proliferation of Internet, ERP systems like all the domains of Information Technology have known an important evolution. This final thesis project is a study about the evolution of ERP systems, more precisely about their migration to the Web giving birth to a new generation of systems: the Web-Based or Web-enabled ERP systems. This migration to the Web is justified by the difficulty of making possible the communication between partner’s legacy systems and the organizations’ ERP syste...

  4. Supporting Infrastructure and Acceptability Issues Associated With Two New Generation Vehicles: P2000 and EXS2

    Energy Technology Data Exchange (ETDEWEB)

    Das, S

    2000-06-06

    As the Partnership for a New Generation of Vehicles (PNGV) has been proceeding with the development of designs for high-fuel-economy vehicles, it also has been assessing whether impediments exist to the transition to these vehicles. Toward that end, as materials options and vehicle designs have been developed, Oak Ridge National Laboratory (ORNL) has been conducting analyses related to the attendant materials infrastructure requirements. This report addresses the question, what are the infrastructure requirements, acceptance issues, and life-cycle impacts associated with PNGV vehicles constructed of lightweight materials.

  5. Looking Ahead—A New Generation of High Performance Refractory Ceramics

    Institute of Scientific and Technical Information of China (English)

    ZHONGXiangchong

    2002-01-01

    It is expected that in the new century, to cope with developments of new high temperature technologies, a new generation of high performance refractory ceramics will emerge and flourish which should include the following (1) oxide and nonoxide composites characterized by a unique combination of high hot strength, high thermal shock resistance and high corrosion resistance;(2) free CaO bearing basic refractories capable of purifying molten metal for improving cleanliness and of absorbing contaminants from waste gases for reducing environmental pollution;(3) free flowing zero cement castables with improved thermomechanical properties, thermal shock resistance and corrosion resistance and gradient castables with varying matrix composition and varying texture.

  6. A New Generation Method for Spatial-Temporal Correlated MIMO Nakagami Fading Channel

    Directory of Open Access Journals (Sweden)

    Qiu-Ming Zhu

    2012-01-01

    Full Text Available A new generation method for spatial and temporal correlated multiple-input multiple-output (MIMO Nakagami fading channel is proposed, which has low complexity and is applicable for arbitrary fading parameters and prespecified correlation coefficients of different subchannel. The new scheme can be divided into two steps: (1 generate independent Nakagami fading sequences for each subchannel based on a novel rejection method; (2 introduce the temporal and spatial correlation based on the relationships between Rayleigh, Gamma, and Nakagami random processes. The analysis and simulation results show that the proposed simulator has a good agreement with the theoretical model on fading envelope distribution, spatial-temporal correlation characteristic.

  7. The theories and key technologies for the new generation mine wireless information system

    Energy Technology Data Exchange (ETDEWEB)

    Yang, W.; Feng, X.; Cheng, S.; Sun, J. [Beijing Jiaotong University, Beijing (China). Key Laboratory of ARP Optical Network and Advanced Telecommunication Network

    2004-07-01

    Breaking through the traditional mine wireless communication theories and technologies, combining advanced wireless communication technologies, wireless network technologies with optical fiber communication technologies have been proposed to construct a new generation mine wireless information system. This has a full range of functions such as managing mobile communications, vehicle positioning and navigation, personnel positioning and tracing, wireless multimedia surveillance, mobile computing and mine environment parameters monitoring. The relevant theories and key technologies were proposed. The urgency to do research work for China is stressed. 10 refs., 2 figs.

  8. Development of a new generation gravity map of Antarctica. ADGRAV Antarctic Digital Gravity Synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Bell, R.E.; Small, C.; Arko, R.A. [Columbia Univ., Palisades, NY (United States). Lamont-Doherty Earth Observatory

    1999-04-01

    The United States National Science Foundation (NSF) has agreed to support the development of a new generation gravity map of Antarctica (ADGRAW-Antarctic Digital Gravity Synthesis), funding the development of a web based access tool. The goal of this project is the creation of an on-line Antarctic gravity database which will facilitate access to improved high resolution satellite gravity models, in conjunction with shipboard, airborne, and land based gravity measurements for the continental regions. This database will complement parallel projects underway to develop new continental bedrock (BEDMAP) and magnetic (ADMAP) maps of Antarctica.

  9. New generation low-energy probes for ultralight axion and scalar dark matter

    CERN Document Server

    Stadnik, Yevgeny V

    2015-01-01

    We present a brief overview of a new generation of high-precision laboratory and astrophysical measurements to search for ultralight (sub-eV) axion, axion-like pseudoscalar and scalar dark matter, which form either a coherent condensate or topological defects (solitons). In these new detection methods, the sought effects are linear in the interaction constant between dark matter and ordinary matter, which is in stark contrast to traditional searches for dark matter, where the sought effects are quadratic or higher order in the underlying interaction constants (which are extremely small).

  10. Fiber Bragg Grating Sensor as Valuable Technological Platform for New Generation of Superconducting Magnets

    CERN Document Server

    Chiuchiolo, A; Cusano, A; Bajko, M; Perez, J C; Bajas, H; Viret, P; Giordano, M; Breglio, G

    2014-01-01

    New generation of superconducting magnets for high energy applications designed, manufactured and tested at the European Organization for Nuclear Research (CERN) require the implementation of reliable sensors able to monitor the mechanical stresses affecting the winding from fabrication to operation in magnetic field of 13 T. This work deals with the embedding of Fiber Bragg Grating sensors in a short model Nb3Sn dipole magnet in order to monitor the strain developed in the coil during the cool down to 1.9 K, the powering up to 15.8 kA and the warm up, offering perspectives for the replacement of standard strain gauges.

  11. The Political System of Russia in the Program of National Union of New Generation

    Directory of Open Access Journals (Sweden)

    Luydmila V. Klimovich

    2014-09-01

    Full Text Available Russian emigration developed a complex of ideological and political concepts on changing system in Soviet Russia. The focus of the article is on the political program of the National Union of the New Generation. The union was formed in 1930 in Yugoslavia and had offices in many countries. It proclaimed the overthrow of the Bolshevik government. On the base of the involvement of archive documents of the People Labor Union of Russian Solidarists (Frankfurt am Main, the author concludes that this organization does not define the future of political structure of Russia, adopted the position called "nepredreshenchestvo". The analysis shows that the program of this organization was perceived ambiguously.

  12. Synthesis, Characterization and Tribological Evaluation of New Generation Materials for Aluminum Cold Rolling Oils

    OpenAIRE

    Ponnekanti Nagendramma; Bal Mukund Shukla; Dilip Kumar Adhikari

    2016-01-01

    The present concept of being globally “green” puts additional demands on lubricants. They are to be biodegradable and ecofriendly. Therefore, in a search for alternate lubricants meeting the above demands, we have synthesized biodegradable new generation esters using alcohols such as 2,2-dimethyl-1,3-propane diol and 2,2-diethyl-1,3-propane diol and fatty acids like caproic and 2-ethyl caproic in presence of indigenous ion exchange resin catalyst. The synthesized esters were analyzed and char...

  13. Practical experience with welding new generation steel PB2 assigned for power industry

    Energy Technology Data Exchange (ETDEWEB)

    Kwiecinski, Krzysztof; Lomozik, Miroslaw [Instytut Spawalnictwa, Gliwice (Poland); Urzynicok, Michal [Boiler Elements Factory ' ZELKOT' , Koszecin (Poland)

    2010-07-01

    This paper presents a new generation steel PB2 assigned for the power industry. In this article the authors present the results of non-destructive (VT, PT, RT) and destructive (tensile test, bending test, hardness measurements, impact strength, macro- and micrograph, fractography) tests. The major objective of the examinations was to verify properties of welded joints made of PB2 steel. Investigation of welded joints made of PB2 steel was performed in Instytut Spawalnictwa in Gliwice and it brings one of the first positive results for this type of steel in the world. (orig.)

  14. From flexibility HRM to sustainable employability across the lifespan: a multi-sample study

    OpenAIRE

    Bal, P. Matthijs; de Lange, Annet

    2014-01-01

    Many countries across the world face rapid demographic changes, such as the aging of the workforce, and the entrance of a new generation of employees, the so-called Generation Y (Twenge, Campbell, Hoffman, & Lance, 2010). Therefore, organizations have to invest more effort in being attractive employers for younger as well as for older workers. It has been proposed that key to the retention of ageing workers is offering workplace flexibility, so that flexibility enables older workers to remain...

  15. Supporting Infrastructure and Acceptability Issues for Materials Used in New Generation Vehicles

    Energy Technology Data Exchange (ETDEWEB)

    Das, S.; Curlee, T.R.; Jones, D.W.; Leiby, P.E.; Rubin, J.D.; Schexnayder, S.M.; Vogt, D.P.; Wolfe, A.K.

    1999-03-01

    To achieve its goal of producing vehicles that use two thirds less fuel than current vehicles, the Partnership of a New Generation of Vehicles (PNGV) is designing vehicles that will use lightweight materials in place of heavier materials used in current vehicles. using new materials in automobiles will require the development of a supporting infrastructure to produce both the substitute materials and the components of the substitute materials, as well as the automotive parts constructed from the new materials. This report documents a set of analyses that attempt to identify potential barriers--economic, infrastructure, and public acceptance barriers--to the materials substitution in New Generation Vehicles. The analyses rely on hypothetical vehicle market penetration scenarios and material composition. The approach is comprehensive, examining issues ranging from materials availability to their eventual disposition and its effect on the automobile recycling industry, and from supporting industries' capacity to the public acceptability of these vehicles. The analyses focus on two likely substitute materials, aluminum and glass-reinforced polymer composites.

  16. Overview of Researches on Social Capital,Human Capital and Social Integration of New Generation Migrant Workers

    Institute of Scientific and Technical Information of China (English)

    Wenjing; LUAN; Honghong; LU; Yulin; TONG; Danna; LU

    2013-01-01

    With urbanization and socio-economic development,new generation migrant workers play an increasingly important role in urban construction. However,for a long time,their social integration situation in inflow places is not ideal. Academic circle has done a lot of researches,but no effective strategy is so far put forward. Through analysis of domestic and foreign researches,it is found that social capital and human capital have an important influence on social integration of new generation migrant workers. This paper takes this as starting point,combines characteristics of new generation migrant workers,and overviews theories and empirical researches of domestic and foreign famous scholars,to explore the relationship between social capital and human capital and social integration of new generation migrant workers.

  17. TAM Ⅲ -A New Generation Multichannel Microcalorimetric System from Thermometric for Use Within the Pharmaceutical Field

    Institute of Scientific and Technical Information of China (English)

    Dan Forsstr(o)m, Dr

    2003-01-01

    @@ Thermometric AB in Sweden, recently introduced TAM Ⅲ--a new generation multichannel microcalorimetric system. TAM Ⅲ can be used to study various phenomena in the pharmaceutical field such as stability and shelf life, compatibility screening, amorphicity and crystallinity and, polymorphism in terms of heat, heat flow and heat capacity. In a calorimetric experiment a sample is introduced into a reaction vessel, which is subsequently loaded into a calorimeter. The calorimeter is permanently immersed in a precision thermostat that controls the temperature of the calorimeter to within 0. 000001 ℃. The experimental conditions can be controlled by use of various auxiliary equipments. The heat flow caused by the sample is monitored continuously as function of time.

  18. Non-destructive research methods applied on materials for the new generation of nuclear reactors

    Science.gov (United States)

    Bartošová, I.; Slugeň, V.; Veterníková, J.; Sojak, S.; Petriska, M.; Bouhaddane, A.

    2014-06-01

    The paper is aimed on non-destructive experimental techniques applied on materials for the new generation of nuclear reactors (GEN IV). With the development of these reactors, also materials have to be developed in order to guarantee high standard properties needed for construction. These properties are high temperature resistance, radiation resistance and resistance to other negative effects. Nevertheless the changes in their mechanical properties should be only minimal. Materials, that fulfil these requirements, are analysed in this work. The ferritic-martensitic (FM) steels and ODS steels are studied in details. Microstructural defects, which can occur in structural materials and can be also accumulated during irradiation due to neutron flux or alpha, beta and gamma radiation, were analysed using different spectroscopic methods as positron annihilation spectroscopy and Barkhausen noise, which were applied for measurements of three different FM steels (T91, P91 and E97) as well as one ODS steel (ODS Eurofer).

  19. Towards a New Generation of Agricultural System Data, Models and Knowledge Products: Design and Improvement

    Science.gov (United States)

    Antle, John M.; Basso, Bruno; Conant, Richard T.; Godfray, H. Charles J.; Jones, James W.; Herrero, Mario; Howitt, Richard E.; Keating, Brian A.; Munoz-Carpena, Rafael; Rosenzweig, Cynthia

    2016-01-01

    This paper presents ideas for a new generation of agricultural system models that could meet the needs of a growing community of end-users exemplified by a set of Use Cases. We envision new data, models and knowledge products that could accelerate the innovation process that is needed to achieve the goal of achieving sustainable local, regional and global food security. We identify desirable features for models, and describe some of the potential advances that we envisage for model components and their integration. We propose an implementation strategy that would link a "pre-competitive" space for model development to a "competitive space" for knowledge product development and through private-public partnerships for new data infrastructure. Specific model improvements would be based on further testing and evaluation of existing models, the development and testing of modular model components and integration, and linkages of model integration platforms to new data management and visualization tools.

  20. Blind search for 21-cm absorption systems using a new generation of Chinese radio telescopes

    Science.gov (United States)

    Yu, Hao-Ran; Pen, Ue-Li; Zhang, Tong-Jie; Li, Di; Chen, Xuelei

    2017-05-01

    Neutral hydrogen clouds are known to exist in the Universe, however their spatial distributions and physical properties are poorly understood. Such missing information can be studied by the new generation of Chinese radio telescopes through a blind search of 21-cm absorption systems. We forecast the capabilities of surveys of 21-cm absorption systems by two representative radio telescopes in China -the Five-hundred-meter Aperture Spherical radio Telescope (FAST) and Tianlai 21-cm cosmology experiment (Tianlai). Facilitated by either the high sensitivity (FAST) or wide field of view (Tianlai) of these telescopes, more than a thousand 21-cm absorption systems can be discovered in a few years, representing orders of magnitude improvement over the cumulative discoveries in the past half a century.

  1. New Generation of the Monte Carlo Shell Model for the K Computer Era

    CERN Document Server

    Shimizu, Noritaka; Tsunoda, Yusuke; Utsuno, Yutaka; Yoshida, Tooru; Mizusaki, Takahiro; Honma, Michio; Otsuka, Takaharu

    2012-01-01

    We present a newly enhanced version of the Monte Carlo Shell Model method by incorporating the conjugate gradient method and energy-variance extrapolation. This new method enables us to perform large-scale shell-model calculations that the direct diagonalization method cannot reach. This new generation framework of the MCSM provides us with a powerful tool to perform most-advanced large-scale shell-model calculations on current massively parallel computers such as the K computer. We discuss the validity of this method in ab initio calculations of light nuclei, and propose a new method to describe the intrinsic wave function in terms of the shell-model picture. We also apply this new MCSM to the study of neutron-rich Cr and Ni isotopes using the conventional shell-model calculations with an inert 40Ca core and discuss how the magicity of N = 28, 40, 50 remains or is broken.

  2. On the use of new generation mobile phone (smart phone) for retrospective accident dosimetry

    Science.gov (United States)

    Lee, J. I.; Chang, I.; Pradhan, A. S.; Kim, J. L.; Kim, B. H.; Chung, K. S.

    2015-11-01

    Optically stimulated luminescence (OSL) characteristics of resistors, inductors and integrated-circuit (IC) chips, extracted from new generation smart phones, were investigated for the purpose of retrospective accident dosimetry. Inductor samples were found to exhibit OSL sensitivity about 5 times and 40 times higher than that of the resistors and the IC chips, respectively. On post-irradiation storage, the resistors exhibited a much higher OSL fading (about 80 % in 36 h as compared to the value 3 min after irradiation) than IC chips (about 20 % after 36 h) and inductors (about 50 % in 36 h). Higher OSL sensitivity, linear dose response (from 8.7 mGy up to 8.9 Gy) and acceptable fading make inductors more attractive for accident dosimetry than widely studied resistors.

  3. Model of e-learning with electronic educational resources of new generation

    Directory of Open Access Journals (Sweden)

    A. V. Loban

    2017-01-01

    Full Text Available Purpose of the article: improving of scientific and methodical base of the theory of the е-learning of variability. Methods used: conceptual and logical modeling of the е-learning of variability process with electronic educational resource of new generation and system analysis of the interconnection of the studied subject area, methods, didactics approaches and information and communication technologies means. Results: the formalization complex model of the е-learning of variability with electronic educational resource of new generation is developed, conditionally decomposed into three basic components: the formalization model of the course in the form of the thesaurusclassifier (“Author of e-resource”, the model of learning as management (“Coordination. Consultation. Control”, the learning model with the thesaurus-classifier (“Student”. Model “Author of e-resource” allows the student to achieve completeness, high degree of didactic elaboration and structuring of the studied material in triples of variants: modules of education information, practical task and control tasks; the result of the student’s (author’s of e-resource activity is the thesaurus-classifier. Model of learning as management is based on the principle of personal orientation of learning in computer environment and determines the logic of interaction between the lecturer and the student when determining the triple of variants individually for each student; organization of a dialogue between the lecturer and the student for consulting purposes; personal control of the student’s success (report generation and iterative search for the concept of the class assignment in the thesaurus-classifier before acquiring the required level of training. Model “Student” makes it possible to concretize the learning tasks in relation to the personality of the student and to the training level achieved; the assumption of the lecturer about the level of training of a

  4. Millennials considered: A new generation, new approaches, and implications for nursing education.

    Science.gov (United States)

    Pardue, Karen T; Morgan, Patricia

    2008-01-01

    A new generation is pursuing degrees in nursing. These students, 18 to 24 years old, aptly called Millennials, are technologically competent and described as optimistic and group oriented. Their propensity for multitasking, reliance on electronics, and need for immediate feedback often perplex and frustrate faculty and challenge customary approaches to teaching and learning. They often express doubt regarding their academic readiness for college. This article explores the authors' experiences with freshmen students of the Millennial generation and shares insights for working successfully with this cohort of learners. The authors assert that by developing strong partnerships with students, faculty may be able to bridge the generational gap to promote mutual understanding, personal growth, and academic success.

  5. A new generation of spectral extraction and analysis package for Fiber Optics Cassegrain Echelle Spectrograph (FOCES)

    Science.gov (United States)

    Wang, Liang; Grupp, Frank; Kellermann, Hanna; Brucalassi, Anna; Schlichter, Jörg; Hopp, Ulrich; Bender, Ralf

    2016-08-01

    We describe a new generation of spectral extraction and analysis software package (EDRS2) for the Fibre Optics Cassegrain Echelle Spectrograph (FOCES), which will be attached to the 2m Fraunhofer Telescope on the Wendelstein Observatory. The package is developed based on Python language and relies on a variety of third party, open source packages such as Numpy and Scipy. EDRS2 contains generalized image calibration routines including overscan correction, bias subtraction, flat fielding and background correction, and can be supplemented by user customized functions to fit other echelle spectrographs. An optimal extraction method is adopted to obtain the one dimensional spectra, and the output multi order, wavelength calibrated spectra are saved in FITS files with binary table format. We introduce the algorithm and performance of major routines in EDRS2.

  6. A new generation of medical cyclotrons for the 90's

    Energy Technology Data Exchange (ETDEWEB)

    Milton, B.F

    1995-08-01

    Cyclotrons continue to be efficient accelerators for use in radio-isotope production. In recent years, developments in accelerator technology have greatly increased the practical beam current in these machines while also improving the overall system reliability. These developments combined with the development of new isotopes for medicine and industry, and a retiring of older machines indicates a strong future for commercial cyclotrons. In this paper we will survey recent developments in the areas of cyclotron technology as they relate to the new generation of commercial cyclotrons. Existing and potential markets for these cyclotrons will be presented. We will also discuss the possibility of systems capable of extracted energies up to 150 MeV and extracted beam currents of up to 2.0 mA. (author)

  7. New generation of actuators tailored to new ball valve; Neue Antriebsgeneration abgestimmt auf neuen Kugelhahn

    Energy Technology Data Exchange (ETDEWEB)

    Rudin, M. [Marktentwicklung Automatik, Georg Fischer Rohrleitungssysteme AG, Schaffhausen (Switzerland)

    2003-05-01

    Georg Fischer produces high-quality actuator systems of both pneumatic and electrical type for plastic piping systems. Customer benefits have been proven worldwide by the large numbers sold for use in the most diverse applications. These products have been re-engineered applying the latest technical potentials and taking account of future market needs. Georg Fisher will launch this new generation of actuator systems at the ACHEMA 2003. (orig.) [German] Georg Fischer produziert hochwertige Antriebe fuer Kunststoff-Rohrleitungssysteme sowohl in pneumatischer als auch in elektrischer Ausfuehrung. In grossen Stueckzahlen haben sie sich in verschiedensten Einsaetzen und Applikationen zum Nutzen der Kunden weltweit bewaehrt. Unter Anwendung neuester technischer Moeglichkeiten sowie unter Beruecksichtigung zukuenftiger Marktbeduerfnisse wurden diese Produkte einer Neuentwicklung unterzogen. Zur ACHEMA 2003 fuehrt Georg Fischer diese neue Antriebsgeneration in den Markt ein. (orig.)

  8. Economic evaluation of technology for a new generation biofuel production using wastes.

    Science.gov (United States)

    Koutinas, Athanasios; Kanellaki, Maria; Bekatorou, Argyro; Kandylis, Panagiotis; Pissaridi, Katerina; Dima, Agapi; Boura, Konstantina; Lappa, Katerina; Tsafrakidou, Panagiota; Stergiou, Panagiota-Yiolanda; Foukis, Athanasios; Gkini, Olga A; Papamichael, Emmanuel M

    2016-01-01

    An economic evaluation of an integrated technology for industrial scale new generation biofuel production using whey, vinasse, and lignocellulosic biomass as raw materials is reported. Anaerobic packed-bed bioreactors were used for organic acids production using initially synthetic media and then wastes. Butyric, lactic and acetic acid were predominately produced from vinasse, whey, and cellulose, respectively. Mass balance was calculated for a 16,000L daily production capacity. Liquid-liquid extraction was applied for recovery of the organic acids using butanol-1 as an effective extraction solvent which serves also as the alcohol for the subsequent enzyme-catalyzed esterification. The investment needed for the installation of the factory was estimated to about 1.7million€ with depreciation excepted at about 3months. For cellulosics, the installation investment was estimated to be about 7-fold higher with depreciation at about 1.5years. The proposed technology is an alternative trend in biofuel production.

  9. Reliability Oriented Design Tool For the New Generation of Grid Connected PV-Inverters

    DEFF Research Database (Denmark)

    Sintamarean, Nicolae Cristian; Blaabjerg, Frede; Wang, Huai

    2015-01-01

    This paper introduces a reliability-oriented design tool for a new generation of grid-connected photovoltaic (PV) inverters. The proposed design tool consists of a real field mission profile (RFMP) model (for two operating regions: USA and Denmark), a PV panel model, a grid-connected PV inverter...... model, an electrothermal model, and the lifetime model of the power semiconductor devices. An accurate long-term simulation model able to consider the one-year RFMP (solar irradiance and ambient temperature) is developed. Thus, the one-year estimation of the converter device thermal loading distribution...... is achieved and is further used as an input to the lifetime model. The proposed reliability-oriented design tool is used to study the impact of mission profile (MP) variation and device degradation (aging) in the PV inverter lifetime. The obtained results indicate that the MP of the field where the PV...

  10. New Generation of Parton Distributions with Uncertainties from Global QCD Analysis

    CERN Document Server

    Pumplin, Jon; Huston, J; Lai, H L; Nadolsky, P M; Tung, W K

    2002-01-01

    A new generation of parton distribution functions with increased precision and quantitative estimates of uncertainties is presented. This work significantly extends previous CTEQ and other global analyses on two fronts: (i) a full treatment of available experimental correlated systematic errors for both new and old data sets; (ii) a systematic and pragmatic treatment of uncertainties of the parton distributions and their physical predictions, using a recently developed eigenvector-basis approach to the Hessian method. The new gluon distribution is considerably harder than that of previous standard fits. A number of physics issues, particularly relating to the behavior of the gluon distribution, are addressed in more quantitative terms than before. Extensive results on the uncertainties of parton distributions at various scales, and on parton luminosity functions at the Tevatron RunII and the LHC, are presented. The latter provide the means to quickly estimate the uncertainties of a wide range of physical proc...

  11. New Generation of Parton Distributions with Uncertainties from Global QCD Analysis

    CERN Document Server

    Tung, W K

    2002-01-01

    A new generation of parton distribution functions with increased precision and quantitative estimates of uncertainties is presented. This work includes a full treatment of available experimental correlated systematic errors for both new and old data sets and a systematic and pragmatic treatment of uncertainties of the parton distributions and their physical predictions. The new gluon distribution is considerably harder than that of previous standard fits. Extensive results on the uncertainties of parton distributions at various scales, and on parton luminosity functions at the Tevatron RunII and the LHC, are obtained. The latter provide the means to quickly estimate the uncertainties of a wide range of physical processes at these high-energy hadron colliders, such as the production cross sections of the $W,Z$ at the Tevatron and the LHC, and that of a light Higgs.

  12. New generation of parton distributions with uncertainties from global QCD analysis

    CERN Document Server

    Wu Ki Tung

    2002-01-01

    A new generation of parton distribution functions with increased precision and quantitative estimates of uncertainties is presented. This work includes a full treatment of available experimental correlated systematic errors for both new and old data sets and a systematic and pragmatic treatment of uncertainties of the parton distributions and their physical predictions. The new gluon distribution is considerably harder than that of previous standard fits. Extensive results on the uncertainties of parton distributions at various scales, and on parton luminosity functions at the Tevatron RunII and the LHC, are obtained. The latter provide the means to quickly estimate the uncertainties of a wide range of physical processes at these high-energy hadron colliders, such as the production cross sections of the W, Z at the Tevatron and the LHC, and that of a light Higgs. (2 refs).

  13. Developing new-generation machinery for vegetation management on protected wetlands in Poland

    Directory of Open Access Journals (Sweden)

    A.P. Dubowski

    2014-08-01

    Full Text Available Many protected wetlands and (especially fen peatlands in Poland require vegetation management to restore and maintain them as breeding areas for endangered bird species. The current practice of harvesting, baling and transporting grasses, reeds and other vegetation using tracked snow groomers and wheeled farm tractors can conflict with the nature conservation goals for these sites through disturbance of the ground surface and accidents leading to spillage of oil. To address these problems, the Industrial Institute of Agricultural Engineering (PIMR is developing new-generation agricultural machinery that will also be applicable in formal paludiculture. This article describes an innovative method for towing large bales of harvested biomass across wetlands that minimises ground pressure using any vehicle, and the development of amphibian tracked (ATV and hovercraft vehicles for biomass harvesting operations in wetlands.

  14. Towards a New Generation of Agricultural System Data, Models and Knowledge Products: Design and Improvement

    Science.gov (United States)

    Antle, John M.; Basso, Bruno; Conant, Richard T.; Godfray, H. Charles J.; Jones, James W.; Herrero, Mario; Howitt, Richard E.; Keating, Brian A.; Munoz-Carpena, Rafael; Rosenzweig, Cynthia

    2016-01-01

    This paper presents ideas for a new generation of agricultural system models that could meet the needs of a growing community of end-users exemplified by a set of Use Cases. We envision new data, models and knowledge products that could accelerate the innovation process that is needed to achieve the goal of achieving sustainable local, regional and global food security. We identify desirable features for models, and describe some of the potential advances that we envisage for model components and their integration. We propose an implementation strategy that would link a "pre-competitive" space for model development to a "competitive space" for knowledge product development and through private-public partnerships for new data infrastructure. Specific model improvements would be based on further testing and evaluation of existing models, the development and testing of modular model components and integration, and linkages of model integration platforms to new data management and visualization tools.

  15. Synthesis, Characterization and Tribological Evaluation of New Generation Materials for Aluminum Cold Rolling Oils

    Directory of Open Access Journals (Sweden)

    Ponnekanti Nagendramma

    2016-06-01

    Full Text Available The present concept of being globally “green” puts additional demands on lubricants. They are to be biodegradable and ecofriendly. Therefore, in a search for alternate lubricants meeting the above demands, we have synthesized biodegradable new generation esters using alcohols such as 2,2-dimethyl-1,3-propane diol and 2,2-diethyl-1,3-propane diol and fatty acids like caproic and 2-ethyl caproic in presence of indigenous ion exchange resin catalyst. The synthesized esters were analyzed and characterized for their physico chemical properties. In addition, with a view to finding out the possibility of using these esters as aluminum cold rolling oils, their lubricity characteristics, biodegradability and toxicity were also investigated. The products were found to have good potential for use in biodegradable aluminum cold rolling oils meeting IS: 14385-2002 specification.

  16. Family healthcare expenditure on children affiliated to the Medical Insurance for a New Generation.

    Science.gov (United States)

    Rodríguez-Ortega, Evelyne Eugenia; Pasillas-Torres, Elvira Mireya

    2012-01-01

    To analyze household health expenditures on children who are beneficiaries of the Medical Insurance for a New Generation (SMNG), program created in 2007 to cover healthcare costs of children without social security born after December 1st, 2006. Using the SMNG National Survey, out-the-pocket and catastrophic spending on child health were calculated using several definitions. Results are presented by socioeconomic level, rural and urban areas and for Oportunidades beneficiaries. About 63.3% of households spent an average annual amount of 3320 Mexican pesos (MEX$) on healthcare for beneficiary children. Between 4.3 and 11.6% of households experienced catastrophic spending, depending on the definition adopted. Due to economic trouble, 15.5% of households postponed and 10.0% cancelled medical care for their child. Even though children are affiliated to the SMNG, the economic burden associated with attending their health is still an issue for families.

  17. Radio Telescope Focal Container for the Russian VLBI Network of New Generation

    Science.gov (United States)

    Ipatov, Alexander; Mardyshkin, Vyacheslav; Cherepanov, Andrey; Chernov, Vitaly; Diky, Dmitry; Khvostov, Evgeny; Yevstigneyev, Alexander

    2010-01-01

    This article considers the development of the structure of receivers for Russian radio telescopes. The development of these radio telescopes is undertaken within the project for creating a Russian small-antenna-based radio interferometer of new generation. It is shown that for small antennas (10. 12 meter) the principal unit, which provides the best SNR, is the so-called focal container placed at primary focus. It includes the primary feed, HEMT LNA, and cryogenic cooling system down to 20. K. A new multi-band feed based on traveling wave resonators is used. It has small dimensions, low weight, and allows working with circular polarizations. Thus it can be placed into focal container and cooled with the LNA. A sketch of the focal container, with traveling-wave-resonator feed, and calculations of the expected parameters of the multi-band receiver are presented.

  18. Canopy in the Clouds: Integrating Science and Media to Inspire a New Generation of Scientists

    Science.gov (United States)

    Goldsmith, G. R.; Fulton, A. D.; Witherill, C. D.

    2008-12-01

    Innovative approaches to science education are critical for inspiring a new generation of scientists. In a world where students are inundated with digital media inviting them to explore exciting, emerging disciplines, science often lags behind in using progressive media techniques. Additionally, science education media often neglects to include the scientists conducting research, thereby disconnecting students from the excitement, adventure, and beauty of conducting research in the field. Here we present initial work from a science education media project entitled Canopy in the Clouds. In particular, we address the goals and approach of the project, the logistics associated with generating educational material at a foreign field site, and the challenges associated with effectively integrating science and media. Canopy in the Clouds is designed to engage students in research, motivate a new generation of young scientists, and promote conservation from the perspective of a current research project being conducted in the canopy of a tropical montane cloud forest located in Monteverde, Costa Rica. The project seeks to generate curriculum based on multiple, immersive forms of novel digital media that attract and maintain student attention. By doing so from the perspective of an adventurous research project in a beautiful and highly biodiverse region, we hope to engage students in science and enhance bioliteracy. However, there are considerable logistic considerations associated with such an approach, including safety, travel, permitting, and equipment maintenance. Additionally, the goals of both the scientific research and the educational media project must be balanced in order to meet objectives in a timely fashion. Finally, materials generated in the field must be translated to viable final products and distributed. Work associated with Canopy in the Clouds will thus provide insight into this process and can serve to inform future science education and outreach

  19. ESA New Generation Science Archives: New Technologies Applied to Graphical User Interface Creation

    Science.gov (United States)

    Fernandez, M.; Arviset, C.; Barbarisi, I.; Castellanos, J.; Cheek, N.; Costa, H.; Fajersztejn, N.; Gonzalez, J.; Laruelo, A.; Leon, I.; Ortiz, I.; Osuna, P.; Salgado, J.; Stebe, A.; Tapiador, D.

    2010-12-01

    The Science Archives and VO Team (SAT) has undertaken the effort to build state of the art sub-systems for its new generation of archives. At the time of writing this abstract, the new technology has already been applied to the creation of the SOHO and EXOSAT Science Archive s and will be used to re-engineer some of the already existing ESA Science Archives in the future. The Graphical User Interface sub-system has been designed and developed upon the premises of building a lightweight rich client application to query and retrieve scientific data quickly and efficiently; special attention has been paid to the usability and ergonomics of the interface. The system architecture relies on the Model View Controller pattern, which isolates logic from the graphical interface. Multiple window layout arrangements are possible using a docking windows framework with virtually no limitations (InfoNode). New graphical components have been developed to fulfill project-specific user requirements. For example video animations can be generated at runtime based on image data requests matching a specific search criteria. In addition, interoperability is achieved with other tools for data visualization purposes using internationally approved standards (c.f., IVOA SAMP), a messaging protocol already adopted by several analysis tools (ds9, Aladin, Gaia). In order to avoid the increasingly common network constraints affecting the end-user’s daily work the system has been designed to cope with possible restrictive firewall set up. Therefore, ESA New Generation archives are accessible from anyplace where standard basic port 80 HTTP connections are available.

  20. Clinical application of the ureteroscope assistant placement of peritoneal dialysis catheters%输尿管镜辅助下腹膜透析管置入技术的应用

    Institute of Scientific and Technical Information of China (English)

    朱微; 燕翔; 蒋春明; 张苗

    2012-01-01

    To evaluate the clinical feasibility,safety and effect of the ureteroscope assistant placement of peritoneal dialysis catheters in patients with end stage renal disease (ESRD). Methodology: Thirty two consecutive ESRD patients underwent ureteroscope assistant placement of peritoneal dialysis catheters. Informed consent form was signed by patients under principle of voluntary. All patients were eligible to receive local infiltration anesthesia. Ureteroscopic monitoring was performed via a peer-away sheath through an incision near the umbilicus. A catheter was passed through the peer-away sheath into the true pelvis. A subcutaneous tunnel was created and a point in left lower quadrant was selected as the exit site of the catheter. Results; All the catheters were successfully placed and the mean time of operation was (42 ±15) minutes. The dose of additional local anesthetics during procedure is 20% lidocaine (13 ±5) milliliter. Blood loss was very little in operation. Only 4 cases presented the ascites with little red blood cells which lasted (16 ±5) hours. During mean follow-up period of 12 months, there were no catheter-related complications, such as catheter migration, obstruction,and dialysate leakage. Conclusion:The ureteroscope assistant placement of peritoneal dialysis catheters is worthy to be popularized for it's safty and effectiveness in end stage renal disease ( ESRD) patients.%目的:探讨输尿管镜辅助下腹膜透析管置人技术的临床应用安全性和疗效. 方法:自愿选择腹膜透析替代治疗的终末期肾病患者32例,局麻下采用经皮微创穿刺技术,使用Peer-Away鞘建立腹腔通道,以输尿管镜进入腹腔内定位,并引导腹膜透析管置于膀胱直肠窝或子宫直肠窝,近端建立皮下隧道并经左下腹戳洞引出.结果:全部患者腹膜透析管均放置成功,手术时间(42±15) min,术中用20%盐酸利多卡因(13±5)ml,出血极少,仅4例术后出现淡血

  1. Invertible flexible matrices

    Science.gov (United States)

    Justino, Júlia

    2017-06-01

    Matrices with coefficients having uncertainties of type o (.) or O (.), called flexible matrices, are studied from the point of view of nonstandard analysis. The uncertainties of the afore-mentioned kind will be given in the form of the so-called neutrices, for instance the set of all infinitesimals. Since flexible matrices have uncertainties in their coefficients, it is not possible to define the identity matrix in an unique way and so the notion of spectral identity matrix arises. Not all nonsingular flexible matrices can be turned into a spectral identity matrix using Gauss-Jordan elimination method, implying that that not all nonsingular flexible matrices have the inverse matrix. Under certain conditions upon the size of the uncertainties appearing in a nonsingular flexible matrix, a general theorem concerning the boundaries of its minors is presented which guarantees the existence of the inverse matrix of a nonsingular flexible matrix.

  2. Global Sourcing Flexibility

    DEFF Research Database (Denmark)

    Ørberg Jensen, Peter D.; Petersen, Bent

    2013-01-01

    sourcing flexibility. Here we draw on prior research in the fields of organizational flexibility, international business and global sourcing as well as case examples and secondary studies. In the second part of the paper, we discuss the implications of global sourcing flexibility for firm strategy......Recent studies show that flexibility is a key concern for firms that engage in the global sourcing of services. In this conceptual paper, we seek to explore two central aspects of global sourcing flexibility: In the first part of the paper, we provide a definition of the construct of global...... and operations against the backdrop of the theory-based definition of the construct. We discuss in particular the importance of global sourcing flexibility for operational performance stability, and the trade-off between specialization benefits, emerging from location and service provider specialization, versus...

  3. Call centres: constructing flexibility

    OpenAIRE

    Arzbächer, Sandra; Holtgrewe, Ursula; Kerst, Christian

    2002-01-01

    "The development of call centres as a flexible interface between firms and their environments has been seen as exemplary or even symptomatic of flexible capitalism (Sennett 1998). We are going to point out that they do not just stand for organisational change but also for changes of institutions towards deregulation. Employers and managers hoped for gains of flexibility, decreasing labour costs, and market gains by an expanded 24-hour-service. Surveillance and control by flexib...

  4. Pneumatic flexible shaft couplings

    OpenAIRE

    2007-01-01

    Main effort of every design engineer is reduction of torsional oscillation in any mechanical system. At present this problem can be solved by means of a suitable modification of dynamic properties of flexible shaft couplings according to dynamics in the given systems. But the dynamic properties of nowadays-applied flexible couplings arenot unchangeable because of aging and fatigue processes occurring in flexible coupling elements. Result of this fact causes detuning of mechanical system. Taki...

  5. Communication satellites to enter a new age of flexibility

    Science.gov (United States)

    Balty, Cédric; Gayrard, Jean-Didier; Agnieray, Patrick

    2009-07-01

    To cope with the economical and technical evolutions of the communication market and to better compete with or complement terrestrial networks, satellite operators are requiring more flexible satellites. It allows a better fleet planning potential and back-up policy, a more standardized and efficient procurement process, mission adaptation to market evolution and the possibility of early entry in new markets. New technologies that are developed either for terrestrial networks or for space defense applications would become soon available to satellite and equipment manufacturers. A skilful mix of these new technologies with the older and more mature ones should boost satellite performances and bring flexibility to the new generation of communication satellites. This paper reviews the economical and technical environment of the space communication business for the next decade. It identifies the needs and levels of flexibility that are required by the market but also allowed by technologies, in both a top-down and bottom-up approach.

  6. Evolution of Flying Qualities Analysis: Problems for a New Generation of Aircraft

    Science.gov (United States)

    2010-03-29

    The Wright brothers heeded this advice, and spent considerable time flying gliders to understand the nuances of aircraft controllability before flying...flexible aircraft ( Sensorcraft),75 control of wing rock in the presence of faults70 and air-breathing hypersonic vehicles.74 It is important to note that...1908. [3] G. H. Bryan and W. E. Williams, “The Longitudinal Stability of Aerial Gliders ,” Proceedings of the Royal Society of London, Vol. 73, The

  7. New Generation of ELF/VLF Wave Injection Experiments for HAARP

    Science.gov (United States)

    Sonwalkar, V. S.; Reddy, A.; Watkins, B. J.

    2016-12-01

    We present a ray tracing study to investigate the feasibility of a new generation of wave injection experiments from HAARP transmitter (L 4.9). Highly successful whistler mode wave injection experiments from SIPLE station, Antarctica, have established the importance of such experiments to study magnetospheric wave-particle interactions, and for cold and hot plasma diagnostics [Helliwell and Katsufrakis, 1974; Carpenter and Miller, 1976; Sonwalkar et al., 1997]. Modulated heating experiments from HAARP have shown that it is possible to launch ELF/VLF waves into the magnetosphere that can be observed on the ground after one-, two-, and multi-hop ducted propagation [Inan et al., 2004]. Recent research has also shown that ionospheric heating experiments using HAARP can lead to the formation of magnetospheric ducts [e.g. Milikh et al., 2010; Fallen et al., 2011]. Collectively, these results indicate that the HAARP (or similar) transmitter can be used first to form ducts on nearby L shells, and then to inject and trap transmitter generated ELF/VLF waves in those ducts. Ray tracing studies using a model magnetosphere shows that ELF/VLF waves in a few kilohertz range can be trapped in ducts with L shells near the HAARP transmitter. For example, 1.5 kHz waves injected from L shell = 4.9 and altitude = 200 km can be trapped in ducts located within 0.3 L of the transmitter L-shell. The duct parameters needed for ray-trapping are typically duct width dL 0.1-0.3 and duct enhancement factor dNe/Ne 10-20% or more. The location of plasmapause with respect to transmitter plays a role in the nature of trapping. The duct locations and parameters required for trapping ELF/VLF waves inside the ducts are consistent with past observations of ducts generated by the HAARP transmitter. Ray tracing calculations provide trapped wave normal angles, time delays, resonant energetic electron energy, estimates of wave intensity inside the duct, on the ground, and on satellites such DEMETER, Van

  8. Good Practices in Educating and Informing the New Generation of Consumers on Organic Foodstuffs

    Directory of Open Access Journals (Sweden)

    Lelia Voinea

    2015-02-01

    Full Text Available The positive image of organic products among consumers has grown gradually. Today, this image is based on a number of researches and studies conducted by specialized government bodies and private organizations and research institutes that show that these products offer, in terms of their nutritional profile, a high intake of nutrients with positive impact on health. Consumers also know that operators who produce and sell such products are subject to rigorous regulations for obtaining the organic certificate and the right to use the organic logo and are regularly monitored by inspection and certification bodies in this regard – facts that increase the new generation of consumers’ confidence in the quality and safety of these products. Having the aim of highlighting the decisive factors which contribute to the creation of a positive image for the ecological foodstuff among consumers and in order to understand the real motivations of the decisional process of buying these products, an exploring marketing research was realized among the new generation of consumers. Another aim of the investigation is the identification of some problems connected with a possible unbalanced nutritional profile of some ecological products commercialized in Romania and whose consumption may be inadequate for a diet and, implicitly, for some consumers’ health, especially for those having certain food restrictions caused by nutritional diseases from which they suffer. In this regard, we are going to analyse, from a scientific point of view, the nutritional profile of some ecological foodstuff found on the market in Romania, using an accredited and standardized method within the European Union- the SAIN-LIM method. Thereby, the paper aims to highlight the antithesis between the formal positive consumer perception and the nutritional profile of some organic products on the Romanian market. Through this endeavour we intend to draw attention on the need of adopting a

  9. Reversibly Bistable Flexible Electronics

    KAUST Repository

    Alfaraj, Nasir

    2015-05-01

    Introducing the notion of transformational silicon electronics has paved the way for integrating various applications with silicon-based, modern, high-performance electronic circuits that are mechanically flexible and optically semitransparent. While maintaining large-scale production and prototyping rapidity, this flexible and translucent scheme demonstrates the potential to transform conventionally stiff electronic devices into thin and foldable ones without compromising long-term performance and reliability. In this work, we report on the fabrication and characterization of reversibly bistable flexible electronic switches that utilize flexible n-channel metal-oxide-semiconductor field-effect transistors. The transistors are fabricated initially on rigid (100) silicon substrates before they are peeled off. They can be used to control flexible batches of light-emitting diodes, demonstrating both the relative ease of scaling at minimum cost and maximum reliability and the feasibility of integration. The peeled-off silicon fabric is about 25 µm thick. The fabricated devices are transferred to a reversibly bistable flexible platform through which, for example, a flexible smartphone can be wrapped around a user’s wrist and can also be set back to its original mechanical position. Buckling and cyclic bending of such host platforms brings a completely new dimension to the development of flexible electronics, especially rollable displays.

  10. Organizational flexibility estimation

    OpenAIRE

    Komarynets, Sofia

    2013-01-01

    By the help of parametric estimation the evaluation scale of organizational flexibility and its parameters was formed. Definite degrees of organizational flexibility and its parameters for the Lviv region enterprises were determined. Grouping of the enterprises under the existing scale was carried out. Special recommendations to correct the enterprises behaviour were given.

  11. Flexible magnetoimpidence sensor

    KAUST Repository

    Kavaldzhiev, Mincho

    2015-05-01

    Recently, flexible electronic devices have attracted increasing interest, due to the opportunities they promise for new applications such as wearable devices, where the components are required to flex during normal use[1]. In this light, different magnetic sensors, like microcoil, spin valve, giant magnetoresistance (GMR), magnetoimpedance (MI), have been studied previously on flexible substrates.

  12. Flexible 'zoning' aids adaptability.

    Science.gov (United States)

    Corben, Simon

    2013-09-01

    Simon Corben, business development director at Capita Symonds' Health team, examines how 'clever use of zoning' when planning new healthcare facilities could improve hospital design, increase inherent flexibility, and reduce lifetime costs, and argues that a 'loose-fit, non-bespoke approach' to space planning will lead to 'more flexible buildings that are suitable for conversion to alternative uses'.

  13. Flexible ferroelectric organic crystals

    Science.gov (United States)

    Owczarek, Magdalena; Hujsak, Karl A.; Ferris, Daniel P.; Prokofjevs, Aleksandrs; Majerz, Irena; Szklarz, Przemysław; Zhang, Huacheng; Sarjeant, Amy A.; Stern, Charlotte L.; Jakubas, Ryszard; Hong, Seungbum; Dravid, Vinayak P.; Stoddart, J. Fraser

    2016-10-01

    Flexible organic materials possessing useful electrical properties, such as ferroelectricity, are of crucial importance in the engineering of electronic devices. Up until now, however, only ferroelectric polymers have intrinsically met this flexibility requirement, leaving small-molecule organic ferroelectrics with room for improvement. Since both flexibility and ferroelectricity are rare properties on their own, combining them in one crystalline organic material is challenging. Herein, we report that trisubstituted haloimidazoles not only display ferroelectricity and piezoelectricity--the properties that originate from their non-centrosymmetric crystal lattice--but also lend their crystalline mechanical properties to fine-tuning in a controllable manner by disrupting the weak halogen bonds between the molecules. This element of control makes it possible to deliver another unique and highly desirable property, namely crystal flexibility. Moreover, the electrical properties are maintained in the flexible crystals.

  14. Flexible ferroelectric organic crystals

    Science.gov (United States)

    Owczarek, Magdalena; Hujsak, Karl A.; Ferris, Daniel P.; Prokofjevs, Aleksandrs; Majerz, Irena; Szklarz, Przemysław; Zhang, Huacheng; Sarjeant, Amy A.; Stern, Charlotte L.; Jakubas, Ryszard; Hong, Seungbum; Dravid, Vinayak P.; Stoddart, J. Fraser

    2016-01-01

    Flexible organic materials possessing useful electrical properties, such as ferroelectricity, are of crucial importance in the engineering of electronic devices. Up until now, however, only ferroelectric polymers have intrinsically met this flexibility requirement, leaving small-molecule organic ferroelectrics with room for improvement. Since both flexibility and ferroelectricity are rare properties on their own, combining them in one crystalline organic material is challenging. Herein, we report that trisubstituted haloimidazoles not only display ferroelectricity and piezoelectricity—the properties that originate from their non-centrosymmetric crystal lattice—but also lend their crystalline mechanical properties to fine-tuning in a controllable manner by disrupting the weak halogen bonds between the molecules. This element of control makes it possible to deliver another unique and highly desirable property, namely crystal flexibility. Moreover, the electrical properties are maintained in the flexible crystals. PMID:27734829

  15. Flexible Carbon Aerogels

    Directory of Open Access Journals (Sweden)

    Marina Schwan

    2016-09-01

    Full Text Available Carbon aerogels are highly porous materials with a large inner surface area. Due to their high electrical conductivity they are excellent electrode materials in supercapacitors. Their brittleness, however, imposes certain limitations in terms of applicability. In that context, novel carbon aerogels with varying degree of flexibility have been developed. These highly porous, light aerogels are characterized by a high surface area and possess pore structures in the micrometer range, allowing for a reversible deformation of the aerogel network. A high ratio of pore size to particle size was found to be crucial for high flexibility. For dynamic microstructural analysis, compression tests were performed in-situ within a scanning electron microscope allowing us to directly visualize the microstructural flexibility of an aerogel. The flexible carbon aerogels were found to withstand between 15% and 30% of uniaxial compression in a reversible fashion. These findings might stimulate further research and new application fields directed towards flexible supercapacitors and batteries.

  16. New generation typhoid vaccines: an effective preventive strategy to control typhoid fever in developing countries.

    Science.gov (United States)

    Verma, Ramesh; Bairwa, Mohan; Chawla, Suraj; Prinja, Shankar; Rajput, Meena

    2011-08-01

    Typhoid fever is a serious systemic infection, caused by the enteric pathogen Salmonella enterica serovar Typhi, a highly virulent and invasive enteric bacterium. This disease occurs in all parts of world where water supplies and sanitation are substandard. These pathogens then travel to food, drinks and water through house-flies and other vectors. Globally, an estimated 12-33 million cases of enteric fever occur with 216,00-600,000 deaths per year, almost exclusively in the developing countries. Health surveys conducted by the Health Ministry of India in the community development areas indicated a morbidity rate varying from 102-2219/100,000 population in different parts of the country. A limited study in an urban slum showed 1% of children up to 17 years of age suffer from typhoid fever annually. The continued high burden of typhoid fever and the alarming spread of antibiotic resistant strains led the World Health Organization (WHO), almost ten years ago, to recommend immunization using the two new-generation vaccines in school- aged children in areas where typhoid fever posed a significant problem and where antibiotic resistant strains were prevalent. Morbidity and mortality due to high incidence of typhoid fever favors the introduction of typhoid vaccine in routine immunization in India. This vaccine should be given at the age of 2 years with Vi antigen vaccine and at least one more dose be given at 5 years of age.

  17. Development of the new generation real sports open car; Jisedai real open sports sha no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    Uehara, S. [Honda Motor Co. Ltd., Tokyo (Japan)

    2000-01-01

    With the concept of a 'New Generation Real Open Sports Car' in mind, a two-seater open sports car, the HONDA S2000, has been developed. Applying the newly developed technologies listed below, the S2000 became a roadster satisfying demands for environmental protection, safety and comfort, as well as being 'fun to drive' which is the fundamental requirement of a sports car. (1) The engine-layout behind the front axle that enabled a weight distribution ratio of 50 : 50 between the front and rear axles, lowered the center of gravity, and reduced the yaw moment of inertia. (2) The open body, whose weight, body stiffness and crash safety performance are equal to those of a closed body through carrying out measures such as raising the floor tunnel and giving it a box shape section. (3) The 2 L inline 4-cylinder engine that offers high power of 125 PS/L and low exhaust emission levels half of those of Japanese regulation for the year 2000. (4) The 6-speed manual transmission that handles the rev limit of 9000 rpm and offers a light and smooth shift feel. (5) The wind management technology and heater performance that make driving with the top down comfortable even in the winter. (author)

  18. A new generation of pragmatic trials of psychosocial interventions is needed.

    Science.gov (United States)

    Ruggeri, M; Lasalvia, A; Bonetto, C

    2013-06-01

    This Editorial addresses the crucial issue of which research methodology is most suited for capturing the complexity of psychosocial interventions conducted in 'real world' mental health settings. It first examines conventional randomized controlled trial (RCT) methodology and critically appraises its strengths and weaknesses. It then considers the specificity of mental health care treatments and defines the term 'complex' intervention and its implications for RCT design. The salient features of pragmatic RCTs aimed at generating evidence of psychosocial intervention effectiveness are then described. Subsequently, the conceptualization of pragmatic RCTs, and of their further developments - which we propose to call 'new generation' pragmatic trials - in the broader routine mental health service context, is explored. Helpful tools for planning pragmatic RCTs, such as the CONSORT extension for pragmatic trials, and the PRECIS tool are also examined. We then discuss some practical challenges that are involved in the design and implementation of pragmatic trials based on our own experience in conducting the GET UP PIANO Trial. Lastly, we speculate on the ways in which current ideas on the purpose, scope and ethics of mental health care research may determine further challenges for clinical research and evidence-based practice.

  19. The Entirely Subcutaneous Defibrillator – A New Generation and Future Expectations

    Science.gov (United States)

    Ali, Hussam; Lupo, Pierpaolo; Cappato, Riccardo

    2015-01-01

    Although conventional implantable cardioverter-defibrillators (ICDs) have proved effective in the prevention of sudden cardiac death (SCD), they still appear to be limited by non-trivial acute and long-term complications. The recent advent of an entirely subcutaneous ICD (S-ICD) represents a further step in the evolution of defibrillation technology towards a less-invasive approach. This review highlights some historical and current issues concerning the S-ICD that may offer a viable therapeutic option in selected patients at high risk of SCD and in whom pacing is not required. After the CE Mark and US Food and Drug Administration (FDA) approvals, the S-ICD is being implanted worldwide with growing clinical data regarding its safety and efficacy (the EFFORTLESS Registry). The recently developed new generation of S-ICD (EMBLEM, Boston Scientific) demonstrates favourable features including a smaller device, longer longevity and remote-monitoring compatibility. Further innovations in the S-ICD system and potential integration with leadless pacing may play an important role in defibrillation therapy and prevention of SCD in the near future. PMID:26835112

  20. PES Surface Modification Using Green Chemistry: New Generation of Antifouling Membranes.

    Science.gov (United States)

    Nady, Norhan

    2016-04-18

    A major limitation in using membrane-based separation processes is the loss of performance due to membrane fouling. This drawback can be addressed thanks to surface modification treatments. A new and promising surface modification using green chemistry has been recently investigated. This modification is carried out at room temperature and in aqueous medium using green catalyst (enzyme) and nontoxic modifier, which can be safely labelled "green surface modification". This modification can be considered as a nucleus of new generation of antifouling membranes and surfaces. In the current research, ferulic acid modifier and laccase bio-catalyst were used to make poly(ethersulfone) (PES) membrane less vulnerable to protein adsorption. The blank and modified PES membranes are evaluated based on e.g., their flux and protein repellence. Both the blank and the modified PES membranes (or laminated PES on silicon dioxide surface) are characterized using many techniques e.g., SEM, EDX, XPS and SPM, etc. The pure water flux of the most modified membranes was reduced by 10% on average relative to the blank membrane, and around a 94% reduction in protein adsorption was determined. In the conclusions section, a comparison between three modifiers-ferulic acid, and two other previously used modifiers (4-hydroxybenzoic acid and gallic acid)-is presented.

  1. Carbon Dioxide Capture with Ionic Liquids and Deep Eutectic Solvents: A New Generation of Sorbents.

    Science.gov (United States)

    Sarmad, Shokat; Mikkola, Jyri-Pekka; Ji, Xiaoyan

    2017-01-20

    High cost and high energy penalty for CO2 uptake from flue gases are important obstacles in large-scale industrial applications, and developing efficient technology for CO2 capture from technical and economic points is crucial. Ionic liquids (ILs) show the potential for CO2 separation owing to their inherent advantages, and have been proposed as alternatives to overcome the drawbacks of conventional sorbents. Chemical modification of ILs to improve their performance in CO2 absorption has received more attention. Deep eutectic solvents (DESs) as a new generation of ILs are considered as more economical alternatives to cope with the deficiencies of high cost and high viscosity of conventional ILs. This Review discusses the potential of functionalized ILs and DESs as CO2 sorbents. Incorporation of CO2 -philic functional groups, such as amine, in cation and/or anion moiety of ILs can promot their absorption capacity. In general, the functionalization of the anion part of ILs is more effective than the cation part. DESs represent favorable solvent properties and are capable of capturing CO2 , but the research work is scarce and undeveloped compared to the studies conducted on ILs. It is possible to develop novel DESs with promising absorption capacity. However, more investigation needs to be carried out on the mechanism of CO2 sorption of DESs to clarify how these novel sorbents can be adjusted and fine-tuned to be best tailored as optimized media for CO2 capture.

  2. Performance Evaluation of New-Generation Pulse Oximeters in the NICU: Observational Study.

    Science.gov (United States)

    Nizami, Shermeen; Greenwood, Kim; Barrowman, Nick; Harrold, JoAnn

    2015-09-01

    This crossover observational study compares the data characteristics and performance of new-generation Nellcor OXIMAX and Masimo SET SmartPod pulse oximeter technologies. The study was conducted independent of either original equipment manufacturer (OEM) across eleven preterm infants in a Neonatal Intensive Care Unit (NICU). The SmartPods were integrated with Dräger Infinity Delta monitors. The Delta monitor measured the heart rate (HR) using an independent electrocardiogram sensor, and the two SmartPods collected arterial oxygen saturation (SpO2) and pulse rate (PR). All patient data were non-Gaussian. Nellcor PR showed a higher correlation with the HR as compared to Masimo PR. The statistically significant difference found in their median values (1% for SpO2, 1 bpm for PR) was deemed clinically insignificant. SpO2 alarms generated by both SmartPods were observed and categorized for performance evaluation. Results for sensitivity, positive predictive value, accuracy and false alarm rates were Nellcor (80.3, 50, 44.5, 50%) and Masimo (72.2, 48.2, 40.6, 51.8%) respectively. These metrics were not statistically significantly different between the two pulse oximeters. Despite claims by OEMs, both pulse oximeters exhibited high false alarm rates, with no statistically or clinically significant difference in performance. These findings have a direct impact on alarm fatigue in the NICU. Performance evaluation studies can also impact medical device purchase decisions made by hospital administrators.

  3. Spalax™ new generation: A sensitive and selective noble gas system for nuclear explosion monitoring.

    Science.gov (United States)

    Le Petit, G; Cagniant, A; Gross, P; Douysset, G; Topin, S; Fontaine, J P; Taffary, T; Moulin, C

    2015-09-01

    In the context of the verification regime of the Comprehensive nuclear Test ban Treaty (CTBT), CEA is developing a new generation (NG) of SPALAX™ system for atmospheric radioxenon monitoring. These systems are able to extract more than 6cm(3) of pure xenon from air samples each 12h and to measure the four relevant xenon radioactive isotopes using a high resolution detection system operating in electron-photon coincidence mode. This paper presents the performances of the SPALAX™ NG prototype in operation at Bruyères-le-Châtel CEA centre, integrating the most recent CEA developments. It especially focuses on an innovative detection system made up of a gas cell equipped with two face-to-face silicon detectors associated to one or two germanium detectors. Minimum Detectable activity Concentrations (MDCs) of environmental samples were calculated to be approximately 0.1 mBq/m(3) for the isotopes (131m)Xe, (133m)Xe, (133)Xe and 0.4 mBq/m(3) for (135)Xe (single germanium configuration). The detection system might be used to simultaneously measure particulate and noble gas samples from the CTBT International Monitoring System (IMS). That possibility could lead to new capacities for particulate measurements by allowing electron-photon coincidence detection of certain fission products.

  4. Corrosion of New-Generation Steel in Outer Oil Pipeline Environments

    Science.gov (United States)

    Eliyan, Faysal Fayez; Kish, J. R.; Alfantazi, Akram

    2017-01-01

    New-generation high-strength pipeline steels are susceptible to corrosion attacks at their outer surfaces, from bicarbonate and carbonate in the hydrated soils in which pipelines are buried. The nature of the corrosion attacks requires implementing modified electrochemical methods by which the corrosion reactions can be studied comprehensively. From that, the findings can be linked to the alloying elements of the new pipeline materials, to modify them from both the strength and corrosion resistance perspectives. This paper presents an electrochemical study on the corrosion of API-X100 steel, in aerated bicarbonate-carbonate solutions, with cyclic voltammetry. At a fast 10 mV/s scan, over ten cycles, the passive films appeared as transparent layers, regardless of bicarbonate and carbonate concentrations. The surface controlled the reactions more than the passive films. The passive films showed evidence of forming gradually with increased cycling. Carbonate competed with bicarbonate during dissolution, decreasing its rate and making passivation faster. Bicarbonate in carbonate solutions catalyzed dissolution and disrupted passivation. The passive films with increased bicarbonate concentrations had higher transpassivation potentials.

  5. New generation of multi-scale NWP system (GRAPES): general scientific design

    Institute of Scientific and Technical Information of China (English)

    CHEN DeHui; XUE JiShan; YANG XueSheng; ZHANG HongLiang; SHEN XueShun; HU JiangLin; WANG Yu; JI LiRen; CHEN JiaBin

    2008-01-01

    A new generation of numerical prediction system GRAPES (a short form of Global/Regional Assimila-tion and PrEdiction System) was set up in China Meteorological Administration (CMA). This paper fo-cuses on the scientific design and preliminary results of the numerical prediction model in GRAPES, including basic idea and strategy of the general scientific design, multi-scale dynamic core, physical package configuration, architecture and parallelization of the codes. A series of numerical experiments using the real data with horizontal resolutions from 10 to 280 km and idealized experiments with very high resolution up to 100 m are conducted, giving encouraging results supporting the multi-scale ap-plication of GRAPES. The results of operational implementation of GRAPES model in some NWP cen-ters are also presented with stress at evaluations of the capability to predict the main features of pre-cipitation in China. Finally the issues to be dealt with for further development are discussed.

  6. Decreasing Quality of the New Generations of Anti-Müllerian Hormone Assays

    Directory of Open Access Journals (Sweden)

    Krzysztof Lukaszuk

    2014-01-01

    Full Text Available Anti-Müllerian hormone (AMH measurements are widely used to optimize the stimulation protocols. First generation AMH kits correlated well with ovarian reserve and response to stimulation. In the present study we aimed to asses if the new generation kits share the same accurate correlations. Retrospective data were collected from 8323 blood samples. For comparison we used Immunotech I generation kit (ImI 4035 samples, Beckman Coulter II generation kit RUO (BCII RUO 3449, samples and Beckman Coulter II generation kit with IVD certificate (BCII IVD 839 samples. We compared average AMH concentrations measured with different kits, as well as correlation between kits. We also compared average AMH concentrations in sera collected on different cycle days and samples of different quality of preservation. AMH serum concentrations differed for each kit, ranging 4.4 ± 4.12 (mean ± SD for the ImI, 2.68 ± 3.15 for the BCII RUO, and 1.64 ± 2.85 for BCII IVD. The mean differences from an adjusted regression model were −48.7%, −40%, and −69.2%, respectively. In conclusion, the changes of the BC AMH kits are unpredictable; however, the improvement of them is still possible. It would be very dangerous to use elaborated stimulation protocol (based on the Ist generation AMH results with the results from the IInd generation assays.

  7. Materials used in new generation vehicles: supplies, shifts, and supporting infrastructure

    Energy Technology Data Exchange (ETDEWEB)

    Das, S.; Curlee, T.R. [Oak Ridge National Lab., TN (United States); Schexnayder, S.M. [Univ. of Tennessee, Knoxville, (United States)

    1997-08-01

    The Partnership for a New Generation of Vehicles (PNGV) program intends to develop new designs for automobiles that will reduce fuel consumption by two thirds but otherwise have price, comfort, safety, and other measures of performance similar to the typical automobile now on the market. PNGV vehicle designs are expected to substitute lightweight materials, such as aluminum, magnesium, carbon-reinforced polymer composites, glass-reinforced polymer composites, and ultra- light steel, for heavier materials such as steel and iron in automobile components. The target mass of a PNGV vehicle is 1,960 pounds, as compared to the average current vehicle that weights 3,240 pounds. Other changes could include the use of different ferrous alloys, engineering changes, or incorporation of advanced ceramic components. Widespread adoption of these vehicle designs would affect materials markets and require concurrent development and adoption of supporting technologies to supply the materials and to use and maintain them in automobiles. This report identifies what would be required to bring about these changes and developments in materials substitution; identifies reasons that might make these substitutions difficult to accomplish within the overall objectives and timetable of the PNGV program; and identifies any issues arising from the substitution that could prompt consideration of policies to deal with them. The analysis in this paper uses scenarios that assume the production of new generation vehicles will begin in 2007 and that their market share will increase gradually over the following 25 years. The scenarios on which the analysis is based assume a maximum substitution of each potential replacement material considered. This maximum substitution of individual materials (i.e., the amount of replacement material by weight that would be added to the baseline vehicle`s composition) is as follows: ULSAB (high strength steel), 298 lbs.; glass-reinforced composites, 653 lbs.; carbon

  8. Development of New Generation of Thermally-Enhanced Fiber Glass Insulation

    Energy Technology Data Exchange (ETDEWEB)

    Kosny, Jan [ORNL; Yarbrough, David W [ORNL; Childs, Phillip W [ORNL; Miller, William A [ORNL; Atchley, Jerald Allen [ORNL; Shrestha, Som S [ORNL

    2010-03-01

    This report presents experimental and numerical results from thermal performance studies. The purpose of this Cooperative Research and Development Agreement (CRADA) between UT-Battelle, LLC and John s Manville was to design a basic concept of a new generation of thermally-enhanced fiber glass insulation. Different types of Phase Change Materials (PCMs) have been tested as dynamic components in buildings during the last 4 decades. Most historical studies have found that PCMs enhance building energy performance. Some PCM-enhanced building materials, like PCM-gypsum boards or PCM-impregnated concretes have already found their limited applications in different countries. Today, continued improvements in building envelope technologies suggest that throughout Southern and Central U.S. climates, residences may soon be routinely constructed with PCM in order to maximize insulation effectiveness and maintain low heating and cooling loads. The proposed thermally-enhanced fiber glass insulation will maximize this integration by utilizing a highly-efficient building envelope with high-R thermal insulation, active thermal mass and superior air-tightness. Improved thermal resistance will come from modifications in infrared internal characteristics of the fiber glass insulation. Thermal mass effect can be provided by proprietary thermally-active microencapsulated phase change material (PCM). Work carried out at the Oak Ridge National Laboratory (ORNL) on the CRADA is described in this report.

  9. A new generation of small pixel pitch/SWaP cooled infrared detectors

    Science.gov (United States)

    Espuno, L.; Pacaud, O.; Reibel, Y.; Rubaldo, L.; Kerlain, A.; Péré-Laperne, N.; Dariel, A.; Roumegoux, J.; Brunner, A.; Kessler, A.; Gravrand, O.; Castelein, P.

    2015-10-01

    Following clear technological trends, the cooled IR detectors market is now in demand for smaller, more efficient and higher performance products. This demand pushes products developments towards constant innovations on detectors, read-out circuits, proximity electronics boards, and coolers. Sofradir was first to show a 10μm focal plane array (FPA) at DSS 2012, and announced the DAPHNIS 10μm product line back in 2014. This pixel pitch is a key enabler for infrared detectors with increased resolution. Sofradir recently achieved outstanding products demonstrations at this pixel pitch, which clearly demonstrate the benefits of adopting 10μm pixel pitch focal plane array-based detectors. Both HD and XGA Daphnis 10μm products also benefit from a global video datapath efficiency improvement by transitioning to digital video interfaces. Moreover, innovative smart pixels functionalities drastically increase product versatility. In addition to this strong push towards a higher pixels density, Sofradir acknowledges the need for smaller and lower power cooled infrared detector. Together with straightforward system interfaces and better overall performances, latest technological advances on SWAP-C (Size, Weight, Power and Cost) Sofradir products enable the advent of a new generation of high performance portable and agile systems (handheld thermal imagers, unmanned aerial vehicles, light gimbals etc...). This paper focuses on those features and performances that can make an actual difference in the field.

  10. Mapping the thermal history of the Universe with the new generation of CMB spectrum space experiments

    CERN Document Server

    Burigana, C

    2003-01-01

    We have studied the implications of the new generation of CMB spectrum space experiments for our knowledge of the thermal history of the Universe. The combination of two experiments with the sensitivity and the frequency coverage jointly forseen for DIMES and FIRAS II will be able to greatly change our vision of the capability of the CMB spectrum information to constrain physical processes at different cosmic ages. The limits on the energy dissipations at the all cosmic times accessible to CMB spectrum investigations (z < z_therm) could be improved by about two order of magnitudes and even dissipation processes with DE/E ~ 10^-6 could be detected and possibly accurately studied. These results are possible because such levels of accuracy on a so wide frequency range allow to remove the approximate degeneracy both between free-free and Bose-Einstein (BE) like distortions and between Comptonization and BE-like distortions. Finally, we discussed the different signatures imprinted on the CMB spectrum by some la...

  11. The new generation drug candidate molecules: Spectral, electrochemical, DNA-binding and anticancer activity properties

    Science.gov (United States)

    Gölcü, Ayşegül; Muslu, Harun; Kılıçaslan, Derya; Çeşme, Mustafa; Eren, Özge; Ataş, Fatma; Demirtaş, İbrahim

    2016-09-01

    The new generation drug candidate molecules [Cu(5-Fu)2Cl2H2O] (NGDCM1) and [Zn(5-Fu)2(CH3COO)2] (NGDCM2) were obtained from the reaction of copper(II) and zinc(II) salts with the anticancer drug 5-fluoracil (5-Fu). These compounds have been characterized by spectroscopic and analytical techniques. Thermal behavior of the compounds were also investigated. The electrochemical properties of the compounds have been investigated by cyclic voltammetry (CV) using glassy carbon electrode. The biological activity of the NGDCM1 and NGDCM2 has been evaluated by examining their ability to bind to fish sperm double strand DNA (FSdsDNA) with UV spectroscopy. UV studies of the interaction of the 5-Fu and metal derivatives with FSdsDNA have shown that these compounds can bind to FSdsDNA. The binding constants of the compounds with FSdsDNA have also been calculated. Thermal decomposition of the compounds lead to the formation of CuO and ZnO as final products. The effect of proliferation 5-Fu, NGDCM1 and NGDCM2 were examined on the HeLa cells using real-time cell analyzer with three different concentrations.

  12. Coral Reef environment reconstruction using small drones, new generation photogrammetry algorithms and satellite imagery

    Science.gov (United States)

    Elisa, Casella; Rovere, Alessio; Harris, Daniel; Parravicini, Valeriano

    2016-04-01

    Surveys based on Remotely Piloted Aircraft Systems (RPAS), together with new-generation Structure from Motion (SfM) and Multi-View Stereo (MVS) reconstruction algorithms have been employed to reconstruct the shallow bathymetry of the inner lagoon of a coral reef in Moorea, French Polinesia. This technique has already been used with a high rate of success on coastal environments (e.g. sandy beaches and rocky shorelines) reaching accuracy of the final Digital Elevation Model in the order of few centimeters. The application of such techniques to reconstruct shallow underwater environments is, though, still little reported. We then used the bathymetric dataset obtained from aerial pictures as ground-truth for relative bathymetry obtained from satellite imagery (WorldView-2) of a larger area within the same study site. The first results of our work suggest that RPAS coupled with SfM and MVS algorithms can be used to reconstruct shallow water environments with favorable weather conditions, and can be employed to ground-truth to satellite imagery.

  13. PES Surface Modification Using Green Chemistry: New Generation of Antifouling Membranes

    Directory of Open Access Journals (Sweden)

    Norhan Nady

    2016-04-01

    Full Text Available A major limitation in using membrane-based separation processes is the loss of performance due to membrane fouling. This drawback can be addressed thanks to surface modification treatments. A new and promising surface modification using green chemistry has been recently investigated. This modification is carried out at room temperature and in aqueous medium using green catalyst (enzyme and nontoxic modifier, which can be safely labelled “green surface modification”. This modification can be considered as a nucleus of new generation of antifouling membranes and surfaces. In the current research, ferulic acid modifier and laccase bio-catalyst were used to make poly(ethersulfone (PES membrane less vulnerable to protein adsorption. The blank and modified PES membranes are evaluated based on e.g., their flux and protein repellence. Both the blank and the modified PES membranes (or laminated PES on silicon dioxide surface are characterized using many techniques e.g., SEM, EDX, XPS and SPM, etc. The pure water flux of the most modified membranes was reduced by 10% on average relative to the blank membrane, and around a 94% reduction in protein adsorption was determined. In the conclusions section, a comparison between three modifiers—ferulic acid, and two other previously used modifiers (4-hydroxybenzoic acid and gallic acid—is presented.

  14. Diagnostic tool for red blood cell membrane disorders: Assessment of a new generation ektacytometer.

    Science.gov (United States)

    Da Costa, Lydie; Suner, Ludovic; Galimand, Julie; Bonnel, Amandine; Pascreau, Tiffany; Couque, Nathalie; Fenneteau, Odile; Mohandas, Narla

    2016-01-01

    Inherited red blood cell (RBC) membrane disorders, such as hereditary spherocytosis, elliptocytosis and hereditary ovalocytosis, result from mutations in genes encoding various RBC membrane and skeletal proteins. The RBC membrane, a composite structure composed of a lipid bilayer linked to a spectrin/actin-based membrane skeleton, confers upon the RBC unique features of deformability and mechanical stability. The disease severity is primarily dependent on the extent of membrane surface area loss. RBC membrane disorders can be readily diagnosed by various laboratory approaches that include RBC cytology, flow cytometry, ektacytometry, electrophoresis of RBC membrane proteins and genetics. The reference technique for diagnosis of RBC membrane disorders is the osmotic gradient ektacytometry. However, in spite of its recognition as the reference technique, this technique is rarely used as a routine diagnosis tool for RBC membrane disorders due to its limited availability. This may soon change as a new generation of ektacytometer has been recently engineered. In this review, we describe the workflow of the samples shipped to our Hematology laboratory for RBC membrane disorder analysis and the data obtained for a large cohort of French patients presenting with RBC membrane disorders using a newly available version of the ektacytomer.

  15. Grafted polysaccharides - new generation polymeric flocculants for treatment of coal fines suspension

    Energy Technology Data Exchange (ETDEWEB)

    Karmakar, N.C. [Indian School of Mines, Dhanbad (India)

    2002-07-01

    Though washing of coking coal for steel plant use is a standard practice, washing of non-coking coal is also fast picking up for the end use in thermal power plants. The effluent from coal washery contains high percentage of coal fines, which is not only of economic concern but also is a potential source of river water pollution. Lots of research works have been and are being carried out to formulate suitable flocculants for the treatment of coal washing effluent in the thickener. Nowadays, synthetic polymers have mostly replaced the inorganic and organic polymers. So far mostly linear synthetic polymers have been tried and their performance is not up to the satisfaction especially for non-coking coals. In the present work, a series of new generation graft copolymers have been synthesised by grafting polyacrylamide chains onto the strong backbone of polysaccharides, namely starch, amylose, amylopectin, sodium algenate and CMC. It is observed that all the graft copolymers possess good flocculation quality on coal fines suspension. Amylopectin-g-polyacrylamide has performed the best on both coking as well as non-coking coal fines suspension, and hence, has the potential for application in the treatment of effluent generated from coal washing plants. 6 refs., 6 figs., 1 tab.

  16. Characterization of a new generation of computed radiography system based on line scanning and phosphor needles

    Science.gov (United States)

    Dragusin, Octavian; Rogge, Frank; Pauwels, Herman; Marchal, Guy; Bosmans, Hilde

    2006-03-01

    A new generation CR system that is based on phosphor needles and that uses a digitizer with line scan technology was compared to a clinically used CR system. Purely technical and more clinically related tests were run on both systems. This included the calculation of the DQE, signal-to-noise and contrast to noise ratios from Aluminum inserts, contrast detail analysis with the CDRAD phantom and the use of anthropomorphic phantoms (wrist, chest and skull) with scoring by a radiologist. X-ray exposures with various dose levels and 50kV, 70kV and 125kV were acquired. For detector doses above 0.8 μGy, all noise related measurements showed the superiority of the new technology. The MTF confirmed the improvement in sharpness: between 1 and 3 lp/mm increases ranged from 20 to 50%. Further work should be devoted to the determination of the required dose levels in the plate for the different radiological applications.

  17. Development of new generation reduced activation ferritic-martensitic steels for advanced fusion reactors

    Science.gov (United States)

    Tan, L.; Snead, L. L.; Katoh, Y.

    2016-09-01

    International development of reduced activation ferritic-martensitic (RAFM) steels has focused on 9 wt percentage Cr, which primarily contain M23C6 (M = Cr-rich) and small amounts of MX (M = Ta/V, X = C/N) precipitates, not adequate to maintain strength and creep resistance above ∼500 °C. To enable applications at higher temperatures for better thermal efficiency of fusion reactors, computational alloy thermodynamics coupled with strength modeling have been employed to explore a new generation RAFM steels. The new alloys are designed to significantly increase the amount of MX nanoprecipitates, which are manufacturable through standard and scalable industrial steelmaking methods. Preliminary experimental results of the developed new alloys demonstrated noticeably increased amount of MX, favoring significantly improved strength, creep resistance, and Charpy impact toughness as compared to current RAFM steels. The strength and creep resistance were comparable or approaching to the lower bound of, but impact toughness was noticeably superior to 9-20Cr oxide dispersion-strengthened ferritic alloys.

  18. The Scientific Research in Libya: The Role of the New Generation of Researchers

    Directory of Open Access Journals (Sweden)

    Tashani OA

    2009-01-01

    Full Text Available There is a potential for improving the scientific research environment in Libya. One reason to be optimistic about the prospects of the future of science in Libya is the number of postgraduate students in all disciplines who are training in European and North American Universities. According to statistics of the Higher Education Authorities in Libya, there are approximately 3000 Libyan students enrolled in postgraduate studies in British universities alone and almost half of this number in North America [1]. However, research output of Libyan universities’ academic staff members is still very low. For example, a recent survey of published medical literature revealed that the average annual production rate at the Al-Fateh Medical University is 1.4 article/100 academic staff [2]. In my opinion, four major reasons may explain the problems facing scientific research in Arab countries in general and in Libya in particular: 1 Brain Drain 2 Lack of funding 3 Lack of scientific infrastructure and incompetent supportive staff, and 4 Teaching overload. I will discuss the role that the new generation of Libyan researchers* could play to advance the scientific research output in Libya.

  19. Impact of stent length on clinical outcomes of first-generation and new-generation drug-eluting stents.

    Science.gov (United States)

    Konishi, Hirokazu; Miyauchi, Katsumi; Dohi, Tomotaka; Tsuboi, Shuta; Ogita, Manabu; Naito, Ryo; Kasai, Takatoshi; Tamura, Hiroshi; Okazaki, Shinya; Isoda, Kikuo; Daida, Hiroyuki

    2016-04-01

    The aim of this study is to compare first- and new-generation drug-eluting stents (DESs) which are implanted in long lesion. Stent length is known to be a predictor of adverse events after percutaneous coronary intervention (PCI), even with the first-generation DESs. The introduction of new-generation DESs has reduced the rates of adverse clinical events. However, the impact of stent length on long-term clinical outcomes is not well known. A total of 1181 consecutive patients who underwent PCI using either a first-generation DES (n = 885) or a new-generation DES (n = 296) between 2004 and 2011 were investigated. In each of the stent groups, the patients were divided into two groups by stent length (>32 and ≤32 mm) and compared. During the follow-up period, the incidence of major adverse cardiac events (MACEs) was significantly higher for patients with long stents implanted than with short stents (P stent groups in the new-generation DES group (P = 0.24; log-rank test). On multivariate Cox regression analysis, stent length was not associated with adverse events in the new-generation DES groups [hazard ratio (HR) 0.87; 95 % confidence interval (95 % CI) 0.71-1.04; P = 0.14]. Implanted stent length was significantly associated with a higher risk of MACEs in patients who received first-generation DESs, but not in patients who received the new-generation DESs.

  20. A Survey and Analysis on the New Generation of Migrant Workers' Awareness of Internet New Words in Foshan City

    Institute of Scientific and Technical Information of China (English)

    Hui LIU[1; Qianqian Zheng[2

    2015-01-01

    50 new generation of migrant workers were randomly chosen from Yanbu Town which is in Nanhai district,Foshan city, Gua ngdong Province.They were asked to complete the questionnaires about the awareness of interact new words.The statistics show that the average awareness of new generation of migrant workers on interact new words is low as a whole. The reasons may lie in workers' overtime working ,relatively closed working environment, low social status,low income and education level and so on.

  1. Painful Flexible Flatfoot.

    Science.gov (United States)

    Sheikh Taha, Abdel Majid; Feldman, David S

    2015-12-01

    Flatfoot is commonly encountered by pediatric orthopedic surgeons and pediatricians. A paucity of literature exists on how to define a flatfoot. The absence of the medial arch with a valgus hindfoot is the hallmark of this pathology. Flatfoot can be flexible or rigid. This review focuses on the diagnosis and treatment of the flexible flatfoot. Most flatfeet are flexible and clinically asymptomatic, and warrant little intervention. If feet are symptomatic, treatment is needed. Most patients who require treatment improve with foot orthotics and exercises. Only feet resistant to conservative modalities are deemed surgical candidates. The presence of a tight heel cord is often found in patients who fail conservative management.

  2. Flexible Support Stanchion

    Energy Technology Data Exchange (ETDEWEB)

    Rudland, D.L.; /Fermilab

    1987-05-11

    Figure 1 shows the assembly drawing of the Central Calorimeter Cryostat Flexible Support Stanchion. Figures 2 and 3 show the Flexible Support STanchion in detail. These Stanchions support the cryostat safely, reduce the heat load to the cryostat from the ambient by a factor of more than ten, provide a spring like action that reduce the loads created by thermal contraction of the cryostat and position the cryostate accurately. Table 1 shows all of the details of the Flexible Support system for the C.C. Cryostat.

  3. Capabilities and performance of Elmer/Ice, a new-generation ice sheet model

    Directory of Open Access Journals (Sweden)

    O. Gagliardini

    2013-08-01

    Full Text Available The Fourth IPCC Assessment Report concluded that ice sheet flow models, in their current state, were unable to provide accurate forecast for the increase of polar ice sheet discharge and the associated contribution to sea level rise. Since then, the glaciological community has undertaken a huge effort to develop and improve a new generation of ice flow models, and as a result a significant number of new ice sheet models have emerged. Among them is the parallel finite-element model Elmer/Ice, based on the open-source multi-physics code Elmer. It was one of the first full-Stokes models used to make projections for the evolution of the whole Greenland ice sheet for the coming two centuries. Originally developed to solve local ice flow problems of high mechanical and physical complexity, Elmer/Ice has today reached the maturity to solve larger-scale problems, earning the status of an ice sheet model. Here, we summarise almost 10 yr of development performed by different groups. Elmer/Ice solves the full-Stokes equations, for isotropic but also anisotropic ice rheology, resolves the grounding line dynamics as a contact problem, and contains various basal friction laws. Derived fields, like the age of the ice, the strain rate or stress, can also be computed. Elmer/Ice includes two recently proposed inverse methods to infer badly known parameters. Elmer is a highly parallelised code thanks to recent developments and the implementation of a block preconditioned solver for the Stokes system. In this paper, all these components are presented in detail, as well as the numerical performance of the Stokes solver and developments planned for the future.

  4. Investigating a new generation of ribozymes in order to target HCV.

    Directory of Open Access Journals (Sweden)

    Michel V Lévesque

    Full Text Available For a long time nucleic acid-based approaches directed towards controlling the propagation of Hepatitis C Virus (HCV have been considered to possess high potential. Towards this end, ribozymes (i.e. RNA enzymes that specifically recognize and subsequently catalyze the cleavage of their RNA substrate present an attractive molecular tool. Here, the unique properties of a new generation of ribozymes are taken advantage of in order to develop an efficient and durable ribozyme-based technology with which to target HCV (+ RNA strands. These ribozymes resulted from the coupling of a specific on/off adaptor (SOFA to the ribozyme domain derived from the Hepatitis Delta Virus (HDV. The former switches cleavage activity "on" solely in the presence of the desired RNA substrate, while the latter was the first catalytic RNA reported to function naturally in human cells, specifically in hepatocytes. In order to maximize the chances for success, a step-by-step approach was used for both the design and the selection of the ribozymes. This approach included the use of both bioinformatics and biochemical methods for the identification of the sites possessing the greatest potential for targeting, and the subsequent in vitro testing of the cleavage activities of the corresponding SOFA-HDV ribozymes. These efforts led to a significant improvement in the ribozymes' designs. The ability of the resulting SOFA-HDV ribozymes to inhibit HCV replication was further examined using a luciferase-based replicon. Although some of the ribozymes exhibited high levels of cleavage activity in vitro, none appears to be a potential long term inhibitor in cellulo. Analysis of recent discoveries in the cellular biology of HCV might explain this failure, as well as provide some ideas on the potential limits of using nucleic acid-based drugs to control the propagation of HCV. Finally, the above conclusions received support from experiments performed using a collection of SOFA

  5. Technological Transfer from Research Nuclear Reactors to New Generation Nuclear Power Reactors

    Science.gov (United States)

    Radulescu, Laura; Pavelescu, Margarit

    2010-01-01

    The goal of this paper is the analysis of the technological transfer role in the nuclear field, with particular emphasis on nuclear reactors domain. The presentation is sustained by historical arguments. In this frame, it is very important to start with the achievements of the first nuclear systems, for instant those with natural uranium as fuel and heavy water as moderator, following in time through the history until the New Generation Nuclear Power Reactors. Starting with 1940, the accelerated development of the industry has implied the increase of the global demand for energy. In this respect, the nuclear energy could play an important role, being essentially an unlimited source of energy. However, the nuclear option faces the challenges of increasingly demanding safety requirements, economic competitiveness and public acceptance. Worldwide, a significant amount of experience has been accumulated during development, licensing, construction, and operation of nuclear power reactors. The experience gained is a strong basis for further improvements. Actually, the nuclear programs of many countries are addressing the development of advanced reactors, which are intended to have better economics, higher reliability, improved safety, and proliferation-resistant characteristics in order to overcome the current concerns about nuclear power. Advanced reactors, now under development, may help to meet the demand for energy power of both developed and developing countries as well as for district heating, desalination and for process heat. The paper gives historical examples that illustrate the steps pursued from first research nuclear reactors to present advanced power reactors. Emphasis was laid upon the fact that the progress is due to the great discoveries of the nuclear scientists using the technological transfer.

  6. Synthesis and Evaluation of New Generation Cross-Bridged Bifunctional Chelator for (64)Cu Radiotracers.

    Science.gov (United States)

    Dale, Ajit V; An, Gwang Il; Pandya, Darpan N; Ha, Yeong Su; Bhatt, Nikunj; Soni, Nisarg; Lee, Hochun; Ahn, Heesu; Sarkar, Swarbhanu; Lee, Woonghee; Huynh, Phuong Tu; Kim, Jung Young; Gwon, Mi-Ri; Kim, Sung Hong; Park, Jae Gyu; Yoon, Young-Ran; Yoo, Jeongsoo

    2015-09-08

    Bifunctional chelators have been successfully used to construct (64)Cu-labeled radiopharmaceuticals. Previously reported chelators with cross-bridged cyclam backbones have various essential features such as high stability of the copper(II) complex, high efficiency of radiolabeling at room temperature, and good biological inertness of the radiolabeled complex, along with rapid body clearance. Here, we report a new generation propylene-cross-bridged chelator with hybrid acetate/phosphonate pendant groups (PCB-TE1A1P) developed with the aim of combining these key properties in a single chelator. The PCB-TE1A1P was synthesized from cyclam with good overall yield. The Cu(II) complex of our chelator showed good robustness in kinetic stability evaluation experiments, such as acidic decomplexation and cyclic voltammetry studies. The Cu(II) complex of PCB-TE1A1P remained intact under highly acidic conditions (12 M HCl, 90 °C) for 8 d and showed quasi-reversible reduction/oxidation peaks at -0.77 V in electrochemical studies. PCB-TE1A1P was successfully radiolabeled with (64)Cu ions in an acetate buffer at 60 °C within 60 min. The electrophoresis study revealed that the (64)Cu-PCB-TE1A1P complex has net negative charge in aqueous solution. The biodistribution and in vivo stability study profiles of (64)Cu-PCB-TE1A1P indicated that the radioactive complex was stable under physiological conditions and cleared rapidly from the body. A whole body positron emission tomography (PET) imaging study further confirmed high in vivo stability and fast clearance of the complex in mouse models. In conclusion, PCB-TE1A1P has good potential as a bifunctional chelator for (64)Cu-based radiopharmaceuticals, especially those involving peptides.

  7. Complex of the new generation of the instrumental analytical approaches to prevent dangerous bioterrorism

    Science.gov (United States)

    Starodub, Nickolaj F.; Shavanova, Kateryna; Karpiuk, Andrii

    2014-10-01

    The real manifestations of biowarfare were only during local military conflicts. In previous times the danger with this factor forms through activation of terrorist organizations. To prevent non-desirable consequences and to preserve the lives and health of people it is necessary to provide constant control by the application of complex of the new generation of the instrumental devices based on the principles of biosensorics which allow rapid revealing step by step: total toxicity of environmental objects, presence of appropriate groups and specific chemical substances among them. It is demonstrated simple and rapid estimation of the total toxicity through the control of the intensity of chlorophyll fluorescence (IChF) by the direct or remote ways by the device "Floratest" (Ukraine). There is possible on the basis of IChF curve of growing plants from some territory during appropriate period to reveal appearance of toxic substances in this area. Their presence in more local cases may be done by using bioluminescent bacteria (pure Ukrainian strains) or/and controlling short term Daphnia living medium by developed portable chemiluminometer. For the revealing of some groups of toxic elements it is recommended the cerium oxide ISFETs based enzymatic biosensors. The last and devices based on SPR ("Plasmotest", Ukraine), porous silicon (with the registration of biospecific interaction macromolecules by luminescence or electro conductivity) and some nano-metal oxides were realized in immune biosensors at the determination of content of number of mycotoxins, some microorganisms (Salmonella spp.) and diagnostics of viral disease (retroviral leucosis). We present the main characteristics of the above mentioned devices and give confirmation that all the analysis meets practice demands. Overall time of analysis is in range 10 min and it is very simple and may be realized in field conditions.

  8. BLEPHAROPLASTY AND PERIOCULAR SKIN RESURFACING WITH NEW GENERATION ER:YAG LASER

    Directory of Open Access Journals (Sweden)

    Brigita Drnovšek-Olup

    2002-12-01

    Full Text Available Background. In this study, a new type of Er:YAG laser, emitting irradiation with variable pulse duration, has been used for blepharoplasty and skin resurfacing in periocular region.More than 40 patients have been treated with second generation Er:YAG laser (Fotona Fidelis for blepharoplasty and skin resurfacing. A focused laser beam (diameter 0.4 mm with very short pulse width (100 µs, that is significantly below the thermal relaxation time of skin, leads to a precise cut with no observable thermal effect on surrounding tissue. The depth of the cut is approximately 1–2 mm, precision comparable to a surgical scalpel. The high repetition rate of consecutive laser pulses (50 Hz at 120 mJ energy accounts for accumulation of thermal load in tissue, and thus leads to complete hemostasis of the cut tissue. Due to improved cutting abilities of the Er:YAG laser, excision of orbital fat is also performed with one pass of the laser beam. By changing the laser parameters to short pulses (300 µs, energy 500 mJ, spot diameter 5 mm and repetition rate 12–15 Hz, skin resurfacing was performed. No special pretreatment therapy was used. Anesthesia: 2% Xylocain inj. subcutaneously. Non adhesive dressing for 24 hours was applied after surgery.Epithelisation was complete after ten days. Redness persists up to 5 weeks. Discomfort of patients was mild. Cosmetic results are satisfying.Conclusions. New generation of Er:YAG laser offers a possibility to cut and coagulate the tissue simultaneously, and by changing the parameters to ablate the tissue with heating influence on skin collagen.

  9. Development and optimization of new generation Start-Up Instrumentation systems (SUI) for domestic CANDU reactors

    Science.gov (United States)

    Nasimi, Elnara

    Due to the age and operating experience of Bruce Power units, equipment ageing and obsolescence has become one of the main challenges that need to be resolved for all systems, structures and components in order to ensure a safe and reliable production of energy. The research objectives of this thesis will focus on methodology for modernization of Start-Up Instrumentation (SUI), both in-core and Control Room equipment, using a new generation of detectors and cables in order to manage obsolescence. The main objective of this thesis is to develop a new systematic approach to SUI installation/replacement procedure development and optimization. Although some additional features, such as real-time data monitoring and storage/archiving solutions for SUI systems are also examined to take full advantage of today's digital technology, the objective of this thesis does not include detailed parametrical studies of detector or system performance. Instead, a number of technological, operational and maintenance issues associated with Start-Up Instrumentation systems at Bruce Power will be identified in this project and a structured approach to developing a replacement/installation procedure that can be standardized and used across all of the domestic CANDU stations is proposed. Finally, benefits of Hierarchical Control Chart (HCC) methodology for all stages of plant life management, such as system design, development, operation and maintenance are demonstrated. Keywords: Task Breakdown and Analysis methodology, installation/removal procedure development and optimization, risk-based analysis and optimization, Hierarchical Control Chart (HCC) methodology for system maintenance and troubleshooting, Start-Up Instrumentation (SUI), Ion Chambers, Fission Chambers, proportional counters, Shutdown System 1 (SDS1), Shutdown System 2 (SDS2).

  10. New generation of space capabilities resulting from US/RF cooperative efforts

    Science.gov (United States)

    Humpherys, Thomas; Misnik, Victor; Sinelshchikov, Valery; Stair, A. T., Jr.; Khatulev, Valery; Carpenter, Jack; Watson, John; Chvanov, Dmitry; Privalsky, Victor

    2006-09-01

    Previous successful international cooperative efforts offer a wealth of experience in dealing with highly sensitive issues, but cooperative remote sensing for monitoring and understanding the global environmental is in the national interest of all countries. Cooperation between international partners is paramount, particularly with the Russian Federation, due to its technological maturity and strategic political and geographical position in the world. Based on experience gained over a decade of collaborative space research efforts, continued cooperation provides an achievable goal as well as understanding the fabric of our coexistence. Past cooperative space research efforts demonstrate the ability of the US and Russian Federation to develop a framework for cooperation, working together on a complex, state-of-the-art joint satellite program. These efforts consisted of teams of scientists and engineers who overcame numerous cultural, linguistic, engineering approaches and different political environments. Among these major achievements are: (1) field measurement activities with US satellites MSTI and MSX and the Russian RESURS-1 satellite, as well as the joint experimental use of the US FISTA aircraft; (2) successful joint Science, Conceptual and Preliminary Design Reviews; (3) joint publications of scientific research technical papers, (4) Russian investment in development, demonstration and operation of the Monitor-E spacecraft (Yacht satellite bus), (5) successful demonstration of the conversion of the SS-19 into a satellite launch system, and (6) negotiation of contractual and technical assistant agreements. This paper discusses a new generation of science and space capabilities available to the Remote Sensing community. Specific topics include: joint requirements definition process and work allocation for hardware and responsibility for software development; the function, description and status of Russian contributions in providing space component prototypes

  11. SCORPIUS, A New Generation of Responsive, Low Cost Expendable Launch Vehicles

    Science.gov (United States)

    Conger, R. E.; Chakroborty, S. P.; Wertz, J. R.

    2002-01-01

    The Scorpius vehicle family extends from one and two stage sub-orbital vehicles for target and science applications to small, medium and heavy lift orbital vehicles. These new liquid fueled vehicles have LEO and GTO capabilities. Microcosm and the Scorpius Space Launch Company (SSLC) are well into the development of this all-new generation of expendable launch vehicles to support commercial and government missions. This paper presents the projected performance of the family of vehicles, status of the development program and projected launch service prices. The paper will discuss the new low cost ablative engines and low cost pressure-fed LOX/Jet-A propulsion systems. Schedules, payload volumes, dispensers, attach fittings, and planned dual manifest capabilities will be presented. The unique configuration of the wide base first stage allows fairings that may extend beyond the current 4-meters. The Scorpius family is designed to facilitate encapsulated payloads and launch-on-demand. The implications of these new operational procedures will be addressed, including the techniques that will be used to drive down the cost of access to space while improving reliability. The Scorpius family of low cost vehicles addresses the full range of payloads from 700 lbs. in the Sprite Mini-Lift to over 50,000 lbs. to LEO in the Heavy-Lift, and over 18,000 lbs. to GTO. Two sub-orbital vehicles have been developed and successfully launched, with the latest vehicle (SR-XM) launched in March of 2001 from White Sands Missile Range. Development of the family of vehicles commenced in 1993 under contracts with the Air Force Research Laboratory Space Vehicle Directorate after a number of years of independent studies and system engineering. The Sprite Mini-Lift Small Expendable Launch Vehicle (SELV) that utilizes the SR-XM technologies is planned for an initial launch in mid 2005 with larger, scaled-up vehicles to follow.

  12. Single cell analysis of yeast replicative aging using a new generation of microfluidic device.

    Directory of Open Access Journals (Sweden)

    Yi Zhang

    Full Text Available A major limitation to yeast aging study has been the inability to track mother cells and observe molecular markers during the aging process. The traditional lifespan assay relies on manual micro-manipulation to remove daughter cells from the mother, which is laborious, time consuming, and does not allow long term tracking with high resolution microscopy. Recently, we have developed a microfluidic system capable of retaining mother cells in the microfluidic chambers while removing daughter cells automatically, making it possible to observe fluorescent reporters in single cells throughout their lifespan. Here we report the development of a new generation of microfluidic device that overcomes several limitations of the previous system, making it easier to fabricate and operate, and allowing functions not possible with the previous design. The basic unit of the device consists of microfluidic channels with pensile columns that can physically trap the mother cells while allowing the removal of daughter cells automatically by the flow of the fresh media. The whole microfluidic device contains multiple independent units operating in parallel, allowing simultaneous analysis of multiple strains. Using this system, we have reproduced the lifespan curves for the known long and short-lived mutants, demonstrating the power of the device for automated lifespan measurement. Following fluorescent reporters in single mother cells throughout their lifespan, we discovered a surprising change of expression of the translation elongation factor TEF2 during aging, suggesting altered translational control in aged mother cells. Utilizing the capability of the new device to trap mother-daughter pairs, we analyzed mother-daughter inheritance and found age dependent asymmetric partitioning of a general stress response reporter between mother and daughter cells.

  13. Toward a new generation of pelvic floor implants with electrospun nanofibrous matrices: A feasibility study.

    Science.gov (United States)

    Vashaghian, Mahshid; Ruiz-Zapata, Alejandra M; Kerkhof, Manon H; Zandieh-Doulabi, Behrouz; Werner, Arie; Roovers, Jan Paul; Smit, Theo H

    2017-03-01

    The use of knitted, polypropylene meshes for the surgical treatment of pelvic organ prolapse (POP) is frequently accompanied by severe complications. Looking for alternatives, we studied the potential of three different electrospun matrices in supporting the adhesion, proliferation, and matrix deposition of POP and non-POP fibroblasts, the most important cells to produce extracellular matrix (ECM), in vitro. We electrospun three commonly used medical materials: nylon; poly (lactide-co-glycolide) blended with poly-caprolactone (PLGA/PCL); and poly-caprolactone blended with gelatin (PCL/Gelatin). The matrices were characterized for their microstructure, hydrophilicity, and mechanical properties. We seeded POP and non-POP fibroblasts from patients with POP and we determined cellular responses and ECM deposition. All matrices had >65% porosity, homogenous microstructures, and close to sufficient tensile strength for pelvic floor repair: 15.4 ± 3.3 MPa for Nylon; 12.4 ± 1.6 MPa for PLGA/PCL; and 3.5 ± 0.9 MPa for PCL/Gelatin. Both the POP and non-POP cells adhered to the electrospun matrices; they proliferated well and produced ample ECM. Overall, the best in vitro performance appeared to be on nylon, presumably because this was the most hydrophilic material with the thinnest fibers. Electrospun nanofibrous matrices show feasible mechanical strength and great biocompatibility for POP and non-POP fibroblasts to produce their ECM in vitro and, thus, may be candidates for a new generation of implants for pelvic floor repair. Further studies on electrospun nanofibrous matrices should focus on mechanical and immunological conditions that would be presented in vivo. Neurourol. Urodynam. 36:565-573, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  14. In vitro fracture resistance of root-filled teeth using new-generation dentine bonding adhesives.

    Science.gov (United States)

    Hürmüzlü, F; Serper, A; Siso, S H; Er, K

    2003-11-01

    To compare the fracture resistance of root-filled premolar teeth restored with new-generation dentine bonding adhesives. Sixty extracted single-rooted human maxillary premolar teeth were used. Access cavities were prepared, and the roots were instrumented with K-files to an apical size 50 using a step-back technique. Root fillings were accomplished using gutta percha (Sure-Endo, Seoul, Korea) and AH Plus root canal sealer (Dentsply DeTrey, Konstanz, Germany) using the lateral condensation technique. The teeth were then randomly divided into six groups of 10 teeth each. A mesiodistocclusal (MOD) cavity was prepared in the teeth to the level of the canal orifices so that the thickness of the buccal wall of the teeth measured 2 mm at the occlusal surface and 3 mm at the cemento-enamel junction. Preparations were restored using the following adhesive systems: Etch & Prime 3.0 (Degussa AG, Hanau, Germany), Clearfil SE Bond (Kuraray, Osaka, Japan), Prompt L-Pop (ESPE, Seefeld, Germany), Panavia F (Kuraray, Osaka, Japan), Optibond Plus (Kerr, Orange, CA, USA) and Admira Bond (Voco, Cuxhaven, Germany); all preparations except those of the Panavia F and Admira Bond groups were further restored with resin composites. The Panavia F group was restored with amalgam and the Admira Bond group with Ormocer (Voco, Cuxhaven, Germany). The teeth were mounted in a Universal Testing Machine (Hounsfield, Surrey, UK), and the buccal walls were subjected to a slowly increasing compressive force until fracture occurred. The force of fracture of the walls of each tooth was recorded and the results in the various groups were compared. Statistical analysis of the data was accomplished using one-way anova. There was no significant difference in the fracture resistance of any of the test groups. In this laboratory study, the type of dentine bonding agents had no influence in the fracture resistance of teeth.

  15. NeXOS, developing and evaluating a new generation of insitu ocean observation systems.

    Science.gov (United States)

    Delory, Eric; del Rio, Joaquin; Golmen, Lars; Roar Hareide, Nils; Pearlman, Jay; Rolin, Jean-Francois; Waldmann, Christoph; Zielinski, Oliver

    2017-04-01

    Ocean biological, chemical or physical processes occur over widely varying scales in space and time: from micro- to kilometer scales, from less than seconds to centuries. While space systems supply important data and information, insitu data is necessary for comprehensive modeling and forecasting of ocean dynamics. Yet, collection of in-situ observation on these scales is inherently challenging and remains generally difficult and costly in time and resources. This paper address the innovations and significant developments for a new generation of insitu sensors in FP7 European Union project "Next generation, Cost- effective, Compact, Multifunctional Web Enabled Ocean Sensor Systems Empowering Marine, Maritime and Fisheries Management" or "NeXOS" for short. Optical and acoustics sensors are the focus of NeXOS but NeXOS moves beyond just sensors as systems that simultaneously address multiple objectives and applications are becoming increasingly important. Thus NeXOS takes a perspective of both sensors and sensor systems with significant advantages over existing observing capabilities via the implementation of innovations such as multiplatform integration, greater reliability through better antifouling management and greater sensor and data interoperability through use of OGC standards. This presentation will address the sensor system development and field-testing of the new NeXOS sensor systems. This is being done on multiple platforms including profiling floats, gliders, ships, buoys and subsea stations. The implementation of a data system based on SWE and PUCK furthers interoperability across measurements and platforms. This presentation will review the sensor system capabilities, the status of field tests and recommendations for long-term ocean monitoring.

  16. A New Generation of PARSEC-COLIBRI Stellar Isochrones Including the TP-AGB Phase

    Science.gov (United States)

    Marigo, Paola; Girardi, Léo; Bressan, Alessandro; Rosenfield, Philip; Aringer, Bernhard; Chen, Yang; Dussin, Marco; Nanni, Ambra; Pastorelli, Giada; Rodrigues, Thaíse S.; Trabucchi, Michele; Bladh, Sara; Dalcanton, Julianne; Groenewegen, Martin A. T.; Montalbán, Josefina; Wood, Peter R.

    2017-01-01

    We introduce a new generation of PARSEC–COLIBRI stellar isochrones that includes a detailed treatment of the thermally pulsing asymptotic giant branch (TP-AGB) phase, covering a wide range of initial metallicities (0.0001 < Zi < 0.06). Compared to previous releases, the main novelties and improvements are use of new TP-AGB tracks and related atmosphere models and spectra for M and C-type stars; inclusion of the surface H+He+CNO abundances in the isochrone tables, accounting for the effects of diffusion, dredge-up episodes and hot-bottom burning; inclusion of complete thermal pulse cycles, with a complete description of the in-cycle changes in the stellar parameters; new pulsation models to describe the long-period variability in the fundamental and first-overtone modes; and new dust models that follow the growth of the grains during the AGB evolution, in combination with radiative transfer calculations for the reprocessing of the photospheric emission. Overall, these improvements are expected to lead to a more consistent and detailed description of properties of TP-AGB stars expected in resolved stellar populations, especially in regard to their mean photometric properties from optical to mid-infrared wavelengths. We illustrate the expected numbers of TP-AGB stars of different types in stellar populations covering a wide range of ages and initial metallicities, providing further details on the “C-star island” that appears at intermediate values of age and metallicity, and about the AGB-boosting effect that occurs at ages close to 1.6-Gyr for populations of all metallicities. The isochrones are available through a new dedicated web server.

  17. Moisture Flux across Colombia in the new generation reanalysis ERA-Interim

    Science.gov (United States)

    Arenas Suárez, T.; Hoyos, I. C.; Rodriguez, B.

    2013-12-01

    The complex regional topography in Northern of South America plays an important role in transport atmospheric processes. The terrain structure controls the moisture flows by strengthening orographic pattern formation of rainfall and convective mesoscale fluxes. In Colombia, the orographic complexity is amplified by the division of the Andes in three branches, which added to the nearness to marine sources and the influence of global climatic phenomena, results in a great spatial and temporal variability of climate that is difficult to capture by modeling. In this contribution we assess the regional representation of moisture flux transport mechanisms from the new generation of reanalysis ERA-Interim, which offers qualitative advantages respect to other climate data sets in tropical areas especially respect to terrain elevation, closure of hydrological cycle representation and over-estimations in precipitation and moisture transport. Temporal and spatial variability of moisture flux divergence (MFD) field are explored in connection with other hydrological variables and global climate phenomena of regional impact. The seasonal moisture transport is mostly driven by the Intertropical Convergence Zone displacement, with dominant sources from the Caribbean Sea and Southeast Pacific whereas the Colombian Pacific is a permanent sink of moisture. Consistently with previous works, the moisture transport occurs mainly by low-level jets, but, contrary to what previous reports state, local humidity has several sources, for instance, the moisture transport over continental area of colombian Pacific has a strong contribution from the Caribbean Sea that intraseasonally is presented in major proportion than the Choco Jet's transport. The spatiotemporal patterns of MFD variability were evaluated through an EOF analysis whose main components are associated in order with: the North Tropical Atlantic and the El Nio Southern Oscillation.

  18. Flexible Batteries: Hierarchical Assemblies of Carbon Nanotubes for Ultraflexible Li-Ion Batteries (Adv. Mater. 31/2016).

    Science.gov (United States)

    Ahmad, Shahab; Copic, Davor; George, Chandramohan; De Volder, Michael

    2016-08-01

    An advanced battery architecture composed of 3D carbon nanotube (CNT) current collectors is used to mitigate stresses in flexible batteries. On Page 6705, C. George, M. De Volder, and co-workers describe the fabrication process and characteristics of this new generation of ultraflexible batteries, which show high rate and cyclablility. These batteries may find applications in the powering of flexible displays and logics. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Development of a new generation of waste form for entrapment and immobilization of highly volatile and soluble radionuclides.

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez, Mark Andrew; Bencoe, Denise Nora; Brinker, C. Jeffrey; Murphy, Andrew Wilson; Holt, Kathleen Caroline; Turnham, Rigney; Kruichak, Jessica Nicole; Tellez, Hernesto; Miller, Andy; Xiong, Yongliang; Pohl, Phillip Isabio; Ockwig, Nathan W.; Wang, Yifeng; Gao, Huizhen

    2010-09-01

    The United States is now re-assessing its nuclear waste disposal policy and re-evaluating the option of moving away from the current once-through open fuel cycle to a closed fuel cycle. In a closed fuel cycle, used fuels will be reprocessed and useful components such as uranium or transuranics will be recovered for reuse. During this process, a variety of waste streams will be generated. Immobilizing these waste streams into appropriate waste forms for either interim storage or long-term disposal is technically challenging. Highly volatile or soluble radionuclides such as iodine ({sup 129}I) and technetium ({sup 99}Tc) are particularly problematic, because both have long half-lives and can exist as gaseous or anionic species that are highly soluble and poorly sorbed by natural materials. Under the support of Sandia National Laboratories (SNL) Laboratory-Directed Research & Development (LDRD), we have developed a suite of inorganic nanocomposite materials (SNL-NCP) that can effectively entrap various radionuclides, especially for {sup 129}I and {sup 99}Tc. In particular, these materials have high sorption capabilities for iodine gas. After the sorption of radionuclides, these materials can be directly converted into nanostructured waste forms. This new generation of waste forms incorporates radionuclides as nano-scale inclusions in a host matrix and thus effectively relaxes the constraint of crystal structure on waste loadings. Therefore, the new waste forms have an unprecedented flexibility to accommodate a wide range of radionuclides with high waste loadings and low leaching rates. Specifically, we have developed a general route for synthesizing nanoporous metal oxides from inexpensive inorganic precursors. More than 300 materials have been synthesized and characterized with x-ray diffraction (XRD), BET surface area measurements, and transmission electron microscope (TEM). The sorption capabilities of the synthesized materials have been quantified by using stable

  20. Flexible Word Classes

    DEFF Research Database (Denmark)

    2013-01-01

    • First major publication on the phenomenon • Offers cross-linguistic, descriptive, and diverse theoretical approaches • Includes analysis of data from different language families and from lesser studied languages This book is the first major cross-linguistic study of 'flexible words', i.e. words...... that cannot be classified in terms of the traditional lexical categories Verb, Noun, Adjective or Adverb. Flexible words can - without special morphosyntactic marking - serve in functions for which other languages must employ members of two or more of the four traditional, 'specialised' word classes. Thus......, flexible words are underspecified for communicative functions like 'predicating' (verbal function), 'referring' (nominal function) or 'modifying' (a function typically associated with adjectives and e.g. manner adverbs). Even though linguists have been aware of flexible world classes for more than...

  1. Flexible displays, rigid designs?

    DEFF Research Database (Denmark)

    Hornbæk, Kasper

    2015-01-01

    Rapid technological progress has enabled a wide range of flexible displays for computing devices, but the user experience--which we're only beginning to understand--will be the key driver for successful designs....

  2. Flexibility in insulin prescription

    Directory of Open Access Journals (Sweden)

    Sanjay Kalra

    2016-01-01

    Full Text Available This communication explores the concept of flexibility, a propos insulin preparations and insulin regimes used in the management of type 2 diabetes. The flexibility of an insulin regime or preparation is defined as their ability to be injected at variable times, with variable injection-meal time gaps, in a dose frequency and quantum determined by shared decision making, with a minimal requirement of glucose monitoring and health professional consultation, with no compromise on safety, efficiency and tolerability. The relative flexibility of various basal, prandial and dual action insulins, as well as intensive regimes, is compared. The biopsychosocial model of health is used to assess the utility of different insulins while encouraging a philosophy of flexible insulin usage.

  3. Ability of the Met kinase inhibitor crizotinib and new generation EGFR inhibitors to overcome resistance to EGFR inhibitors.

    Directory of Open Access Journals (Sweden)

    Shigeki Nanjo

    Full Text Available PURPOSE: Although EGF receptor tyrosine kinase inhibitors (EGFR-TKI have shown dramatic effects against EGFR mutant lung cancer, patients ultimately develop resistance by multiple mechanisms. We therefore assessed the ability of combined treatment with the Met inhibitor crizotinib and new generation EGFR-TKIs to overcome resistance to first-generation EGFR-TKIs. EXPERIMENTAL DESIGN: Lung cancer cell lines made resistant to EGFR-TKIs by the gatekeeper EGFR-T790M mutation, Met amplification, and HGF overexpression and mice with tumors induced by these cells were treated with crizotinib and a new generation EGFR-TKI. RESULTS: The new generation EGFR-TKI inhibited the growth of lung cancer cells containing the gatekeeper EGFR-T790M mutation, but did not inhibit the growth of cells with Met amplification or HGF overexpression. In contrast, combined therapy with crizotinib plus afatinib or WZ4002 was effective against all three types of cells, inhibiting EGFR and Met phosphorylation and their downstream molecules. Crizotinib combined with afatinib or WZ4002 potently inhibited the growth of mouse tumors induced by these lung cancer cell lines. However, the combination of high dose crizotinib and afatinib, but not WZ4002, triggered severe adverse events. CONCLUSIONS: Our results suggest that the dual blockade of mutant EGFR and Met by crizotinib and a new generation EGFR-TKI may be promising for overcoming resistance to reversible EGFR-TKIs but careful assessment is warranted clinically.

  4. Comparison of a new-generation sectorial addition multifocal intraocular lens and a diffractive apodized multifocal intraocular lens.

    NARCIS (Netherlands)

    Linden, J.W.M. van der; Velthoven, M. van; Meulen, I. van der; Nieuwendaal, C.; Mourits, M.; Lapid-Gortzak, R.

    2012-01-01

    PURPOSE: To compare visual, refractive, and satisfactory outcomes between a new-generation sectorial addition multifocal intraocular lens (IOL) (Lentis Mplus LS-312; study group) and a diffractive apodized multifocal IOL (Restor SN6AD1; control group). SETTING: Private practice, Driebergen, and Depa

  5. Questioning the Use of Alcoholics Anonymous with College Students: Is an Old Concept the Only Alternative for a New Generation?

    Science.gov (United States)

    Vick, Ron, Sr.

    2000-01-01

    The recommended treatment for alcoholism in the past typically has been participation in Alcoholics Anonymous (AA). However, the use of AA on college campuses has not been proven effective. With a new generation comes the opportunity to rethink this approach to the problem of alcohol abuse on campuses and to incorporate new methods in counseling…

  6. Comparative study on ureteroscopic lithotripsy and laparoscopic ureterolithotomy for treatment of unilateral upper ureteral stones Estudo comparativo entre litotripsia e ureterolitotomia laparoscópica no tratamento de cálculos unilaterais altos

    Directory of Open Access Journals (Sweden)

    You-qiang Fang

    2012-03-01

    Full Text Available PURPOSE: To compare the curative effects of ureteroscopic lithotripsy and laparoscopic ureterolithotomy for unilateral upper ureteral stones, and to explore optimal surgical indications and skills. METHODS: Fifty cases of unilateral upper ureteral stones were randomly divided into two groups: one group underwent ureteroscopic holmium laser lithotripsy under epidural or lumbar anesthesia (n=25, and another group underwent laparoscopic ureterolithotomy under general anesthesia (n=25. Double-J stent was routinely indwelled in both groups. Operating time, postoperative hospitalization time, stone clearance rate and perioperative complications were compared. RESULTS: Operation was successfully performed in all 50 cases, and no open surgery was converted in any case. In the ureteroscopy and laparoscopy groups, the mean operating time was 49.0±10.7 min and 41.8±8.0 min (t=2.68, P=0.00999, respectively, their hospitalization time was 2.8±1.3 days vs. 2.9±0.8 days (t =-0.40, P=0.69413, and stone clearance rate was 88.0% (22/25 vs. 100% (25/25. Stone moved to the renal pelvis in three cases in the ureteroscopy group, and residual stones were removed by extracorporeal shock-wave lithotripsy (ESWL. All patients were followed up for more than three months, and no serious complications such as ureterostenosis occurred. CONCLUSIONS: Laparoscopic ureterolithotomy has a higher stone clearance rate and shorter operation time compared with ureteroscopic lithotripsy. Laparoscopic ureterolithotomy is one safe and effective treatment on unilateral upper ureteral stones.OBJETIVO: Comparar os efeitos curativos da litotripsia ureteroscópica e a ureterolitotomia laparoscópica para cálculos unilaterais altos e pesquisar as indicações e resultados. MÉTODOS: Cinquenta casos de cálculos unilaterais altos foram distribuídos aleatoriamente em dois grupos: um grupo submetido a litotripsia ureteroscópica com laser holmium sob anestesia epidural ou lombar (n=25 e

  7. Treatment of 88 Cases with Ureteral Calculi by Using Ureteroscopic Pneumatic Ballistic Lithotripsy%输尿管镜气压弹道碎石术治疗88例输尿管结石

    Institute of Scientific and Technical Information of China (English)

    阚乃尧; 杜耀安; 乔羽; 陈健

    2011-01-01

    Objective To evaluate the efficacy of ureteroscopic pneumatic ballistic lithotripsy for ureteral calculi. Methods A retrospective analysis was made in 88 cases treated by ureteroscopic pneumatic ballistic lithotripsy from June 2006 to November 2010. There are 9 cases of bilateral ureteral calculi ,7 cases of isolated renal and 14 cases of acute obstructive renal failure. Results The locations of ureteral calculi were in the upper portion in 20 sides,in the middle portion in 28 sides,in the lower portion in 50 sides. The total success rate of one stage for patients was 91.8% (75.0% in upper portion,92.8% in middle portion,98.0% in lower portion). The mean operation time was 56 minutes( range from 20 to 100 minutes). 3 cases were changed into open operation. 5 cases needed auxiliary ESWL. In the patients with acute obstructive renal failure, the serum Bun and Cr levels decreased at different degree or return to normal. Conclusion The ureteroscopic pneumatic ballistic lithotripsy is safe,effective and less invasive, and is the first choice in the treatment of lower and middle ureteral calculi, which can treat the bilateral ureteral calculi simultaneously;it can rapidly remove the obstruction for the patients with obstructive acute renal failure.%目的 探讨输尿管镜气压弹道碎石术治疗输尿管结石的效果.方法 回顾性分析2004年6月-2010年11月88例输尿管镜气压弹道碎石术治疗输尿管结石的临床资料.其中孤立肾7例,双侧结石9例,急性梗阻性肾功能衰竭14例.结果 输尿管结石位于上、中、下段分别为20侧、28侧、50侧.一次性碎石91.8%,其中上段75.0%,中段92.8%,下段98.0%.3例改开放手术,体外震波碎石术(ESWL)5例.手术时间20~100 min,平均56 min.急性肾功能衰竭患者血BUN,Cr恢复正常或接近正常.结论 输尿管镜气压弹道碎石术安全、高效、损伤小,可作为输尿管中下段结石的首选方法,能同时处理双侧结石.对梗阻性急

  8. Ureteroscopic pneumatic lithotripsy for treatment of complicated ureteral calculi%输尿管镜气压弹道碎石术治疗复杂性输尿管结石

    Institute of Scientific and Technical Information of China (English)

    王文生; 薛建; 俞小明; 张钢; 李鑫; 李保国; 唐科伟

    2011-01-01

    目的 探讨输尿管镜气压弹道碎石术治疗复杂性输尿管结石的疗效.方法 采用输尿管镜气压弹道碎石术治疗复杂性输尿管结石56例,其中输尿管上段结石15例,中下段结石41例,体外冲击波碎石术(ESWL)失败25例,合并高热8例.结果 56例患者中,中下段结石均一次完全粉碎,成功率100.0%(41/41).上段结石一次完全粉碎10例,成功率66.7%(10/15).3例结石术中移位至肾脏,后辅以ESWL治疗1~2次,1例进镜困难终止手术,1例因输尿管穿孔改行开放手术.术后4周结石总清除率87.5%(49/56).8例合并高热者均急诊手术,7例一次结石粉碎成功,1例结石移位至肾脏,但梗阻均经手术得以解除,术后高热停止.输尿管穿孔发生率为1.8%(1/56).结论 输尿管镜气压弹道碎石术治疗复杂性输尿管结石安全、有效.%Objective To evaluate the therapeutic efficacy of ureteroscopic pneumatic lithotripsy for treatment of complicated ureteral calculi. Methods Clinical data of 56 cases with complicated ureteral calculi who were treated with ureteroscopic pneumatic lithotripsy was reviewed. Among them 15 cases were proximal ureteral calculi,41 cases were middle and distal ureteral calculi. Treatment by extracorporeal shockwave lithotripsy (ESWL) failed in 25 cases,8 cases complicated with fever. Results In 41 cases with middle and distal ureteral calculi, successful lithotripsy was achieved after the first treatment session,the success rate was 100.0% (41/41). In 15 cases with proximal ureteral calculi ,successful lithotripsy was achieved in 10 cases after the first treatment session,the success rate was 66.7%(l0/15). Calculi migrated to kidney in 3 cases who treated by ESWL for 1-2 times. The failure was due to ureteral kink in 1 case and due to ureteral perforation that required surgical repair in another case. Forty-nine cases were calculi-free after 4 weeks,the calculi-free rate was 87.5%(49/56). Emergency operation was performed in 8

  9. The clinical application of ureteroscope in the laparoscopic cholecystolithotomy%腹腔镜联合输尿管硬镜在保胆取石术中的临床应用

    Institute of Scientific and Technical Information of China (English)

    肖海波; 胡晋太

    2013-01-01

    Objective:To investigate the feasibility,superiority and surgical techniques of laparoscope-ureteroscope combination in the cholecystolithotomy.Methods:Sixty cases undergoing minimaly-invasive cholecystolithotomy by the same surgeon during Jun.2010 and Oct.2012 were randomly divided into two groups.30 cases undergoing laparoscopic cholecystolithotomy were in the control group while the other 30 cases undergoing laparoseopic cholecystolithotomy combined with ureteroscope were in the observation group.The operation time,recovery time of gastrointestinal function,blood loss,postoperative complications were comparatively analyzed between the two groups.Results:Twenty-nine operations were successful in the control group.1 case was converted to laparotomy because gallstones incarcerated in the neck of gallbladder and removal of calculus failed.All the operations in the observation group were successful.Postoperative follow-up time was 6-12 months.1 case recurred in the control group,CT and color Doppler ultrasound showed choledocholithiasis.No recurrence was found in the observation group.No bile leakage,bleeding or gallbladder carcinoma were observed after operations.The operation time,intraoperative blood loss,gastrointestinal function recovery time and postoperative recurrence between two groups were significantly different (P < 0.05).Conclusions:The laparoscopic cholecystolithotomy combined with ureteroscope is safe and feasible,and has obvious advantages.However,the operation skills remain to be further researched.%目的:探讨腹腔镜联合输尿管硬镜行保胆取石术的可行性、优越性及手术技巧.方法:随机将2010年6月至2012年10月同一术者施行的60例微创保胆手术分为两组,30例行完全腹腔镜保胆取石术(对照组),30例行腹腔镜联合输尿管硬镜保胆取石术(观察组),对比分析两组患者手术时间、胃肠功能恢复时间、术中出血量、术后并发症等.结果:对照组中29例成功完成

  10. The Need and Keys for a New Generation Network Adjustment Software

    Science.gov (United States)

    Colomina, I.; Blázquez, M.; Navarro, J. A.; Sastre, J.

    2012-07-01

    Orientation and calibration of photogrammetric and remote sensing instruments is a fundamental capacity of current mapping systems and a fundamental research topic. Neither digital remote sensing acquisition systems nor direct orientation gear, like INS and GNSS technologies, made block adjustment obsolete. On the contrary, the continuous flow of new primary data acquisition systems has challenged the capacity of the legacy block adjustment systems - in general network adjustment systems - in many aspects: extensibility, genericity, portability, large data sets capacity, metadata support and many others. In this article, we concentrate on the extensibility and genericity challenges that current and future network systems shall face. For this purpose we propose a number of software design strategies with emphasis on rigorous abstract modeling that help in achieving simplicity, genericity and extensibility together with the protection of intellectual proper rights in a flexible manner. We illustrate our suggestions with the general design approach of GENA, the generic extensible network adjustment system of GeoNumerics.

  11. COUPLING EFFECT OF FLEXIBLE JOINT AND FLEXIBLE LINK ON DYNAMIC SINGULARITY OF FLEXIBLE MANIPULATOR

    Institute of Scientific and Technical Information of China (English)

    GAO Zhihui; YUN Chao; BIAN Yushu

    2008-01-01

    The coupling effect of the flexible joint and the flexible link on the dynamic singularity of the flexible manipulator is addressed. Firstly, the dynamic equations of a flexible manipulator with a flexible joint and a flexible link are derived. Secondly, the relationship and property between the flexible joint and the flexible link are analyzed. It shows that the flexible joint's amplitude will increase abruptly, thereby the dynamic singularity occurs if the frequency of a flexible joint is near or equal to some natural frequency of a flexible link. Finally, some numerical simulations which will verify the correctness of the theoretical analysis, are carried out. The results are fundamental for the design of a flexible manipulator and for the avoidance of the dynamic singularity.

  12. 输尿管软镜钬激光碎石术后全身炎症反应综合征的风险因素评估%Risk factors of systemic inflammatory response syndrome following flexible ureteroscopic lithotripsy

    Institute of Scientific and Technical Information of China (English)

    钟文; 赖贺; 赵志健; 曾国华

    2016-01-01

    目的:探讨输尿管软镜钬激光碎石术(FUL)术后发生全身炎症反应综合征(SIRS)的风险因素.方法:分析2012年10月~2014年11月间260例患者临床资料,按术后是否发生SIRS分组,单因素分析比较年龄、性别、BMI、结石大小、尿路感染、肾积水、灌注、输尿管通道鞘、手术时间、结石成分等风险因素,随后通过多因素逻辑回归分析,计算Odds比值(OR)和95%可信区间(95%C1)以确定FUL术后SIRS的独立风险因素.结果:FUL术后SIRS发生率8.1%(21/260).在单因素分析中,SIRS与患者性别(P<0.01)、结石大小(P=0.001)、灌注速度(P<0.01)及灌注量(P <0.01)有显著相关性.多因素逻辑回归分析确定结石大小(OR=1.691,95%CI:0.879~3.255)、小口径输尿管通道鞘(OR=2.293,95%CI:0.730~7.200)、灌注速度(OR=1.161,95%CI:1.096~1.230)及感染性结石(OR=3.331,95%CI:0.971~11.426)为FUL术后SIRS的独立风险因素.结论:结石大负荷、感染性结石是FUL术后SIRS危险因素,具有这些危险因素的患者FUL时应控制手术时间,必要时分期手术;FUL术中宜使用低压低流灌注,并使用大口径输尿管通道鞘提供引流,用以降低FUL术中肾盂内压.

  13. Influence of Social Support on Health-Related Quality of Life in New-Generation Migrant Workers in Eastern China

    Directory of Open Access Journals (Sweden)

    Haiyan Xing

    2013-08-01

    Full Text Available Background: The World Health Organization Quality of Life-BREF (WHOQOL-BREF has generally been used for patients,few studies in migrants who move from rural to urban within one country. Many studies asserted that social isolation presents a risk to individual health. Poor social networks are associated with worse QOL. This study examined health-related quality of life (HRQOL and social support in new-generation migrant workers and compared it with urban workers.Methods: Nine hundred thirty new-generation migrant workers and 939 urban controls completed the WHOQOL-BREF questionnaire and Social Support Rating Scale (SSRS by stratified sampling in 2011. Spearman’s correlation was performed to clarify the relationship between social support and HRQOL in migrants. Multiple linear regression analyses were used to identify the variables that were associated with HRQOL.Results: The general health, psychological health, and environmental scores of QOL in new-generation migrant workers were lower than in urban workers. New-generation migrants had poorer social support compared with urban controls with regard to general support, objective support, and support utilization. A positive correlation was found between social support and HRQOL. Workers with a higher level of education achieved better psychological, environmental, and general scores than workers with a primary education. Physical, social, environmental, and general health was also closely connected with the age factor. Physical health scores were higher in males than in females.Conclusion: These data suggest that new-generation migrant workers have significant impairment in HRQOL and receive less social support. HRQOL may be affected by social support, education, age, and gender.

  14. Fiber optics structural mechanics and nanotechnology based new generation of fiber coatings

    Science.gov (United States)

    Suhir, E.

    2006-02-01

    This paper consists of two parts - review and extension. The review part deals with typical fiber optics structures (bare, single- and dual-coated fibers; fibers experiencing low temperature micro-bending; fibers soldered into ferrules or adhesively bonded into capillaries; role of the non-linear stress-strain relationship, etc.) subjected to thermally induced and/or mechanical loading in bending, tension, compression, or to various combinations of such loadings. The emphasis is on the state-of-the-art in the area of optical fiber coatings and the functional (optical), mechanical and environmental problems that occur in polymer-coated or metallized fibers. The solutions to the examined problems are obtained using analytical methods (predictive models) of structural mechanics. The review is based primarily on the author's research conducted at Bell Laboratories, Murray Hill, NJ, during his eighteen years tenure with this company. The extension part addresses a new generation of optical fiber coatings and deals with the application of a newly developed (by the ERS/Siloptix Co.) nano-particle material (NPM) that is used as an attractive substitute for the existing optical fiber coatings. This NPM-based coating has all the merits of polymer and metal coatings, but is free of their shortcomings. The developed material is an unconventional inhomogeneous "smart" composite material, which is equivalent to a homogeneous material with the following major properties: low Young's modulus, immunity to corrosion, good-to-excellent adhesion to adjacent material(s), non-volatile, stable properties at temperature extremes (from -220°C to +350°C), very long (practically infinite) lifetime, "active" hydrophobicity - the material provides a moisture barrier (to both water and water vapor), and, if necessary, can even "wick" moisture away from the contact surface; ability for "self-healing" and "healing": the NPM is able to restore its own dimensions, when damaged, and is able to

  15. Ultrasonic in-line inspection of pipelines, new generation of tools

    Energy Technology Data Exchange (ETDEWEB)

    Uzelac, Neb I.; Reber, Konrad; Beller, Michael; Barbian, Otto Alfred [NDT Systems and Services (Germany)

    2003-07-01

    In-line inspection (ILI) of pipelines has established itself as the most efficient tool for evaluating the condition of a pipeline and an indispensable part of pipeline integrity management. Historically, there have been two major technologies used in in-line inspection for corrosion, the magnetic flux leakage (MFL) and ultrasonics (UT), each having their distinct properties and fields of application. Ultrasonic (UT) ILI has always provided unique quality of information about the pipelines, rendering highest accuracy and tightest measurement tolerances. In the 1990s ultrasonic tools for detection of cracks have become available. This paper describes the new generation of ultrasonic ILI tools, both for metal loss (corrosion) and crack detection. It has been developed based on the expertise gained utilizing the first generation of UT tools combined with the advancements in electronic, hardware and software components available today. Properties of the new tools are presented. Tool specifications and their defect detection capabilities are discussed, as well as the characteristics that make them unique. The performance of these new tools offers advantages in detection and sizing performance, increased operational convenience and improved reporting. Based on examples from tests and inspection runs, it can be seen that the new tool technology can successfully operate in situations and pipe configurations that UT technology has historically had problems with. Examples of this are shown and it is discussed what kind of applications this technology is best suited for. Also, assessment of defects regarding the remaining strength of the pipe is being discussed and demonstrations shown of how the new UT metal loss tools provide superior results over others in fully using the most advanced defect assessment algorithms. Inspection of pipelines for crack and crack-like defect is another aspect where this technology offers the highest standards within the industry. Examples are

  16. New generation humanized mice for virus research: comparative aspects and future prospects.

    Science.gov (United States)

    Akkina, Ramesh

    2013-01-05

    Work with human specific viruses will greatly benefit from the use of an in vivo system that provides human target cells and tissues in a physiological setting. In this regard humanized mice (hu-Mice) have played an important role in our understanding of viral pathogenesis and testing of therapeutic strategies. Limitations with earlier versions of hu-Mice that lacked a functioning human immune system are currently being overcome. The new generation hu-Mouse models are capable of multilineage human hematopoiesis and generate T cells, B cells, macrophages and dendritic cells required for an adaptive human immune response. Now any human specific pathogen that can infect humanized mice can be studied in the context of ongoing infection and immune responses. Two leading humanized mouse models are currently employed: the hu-HSC model is created by transplantation of human hematopoietic stem cells (HSC), whereas the BLT mouse model is prepared by transplantation of human fetal liver, thymus and HSC. A number of human specific viruses such as HIV-1, dengue, EBV and HCV are being studied intensively in these systems. Both models permit infection by mucosal routes with viruses such as HIV-1 thus allowing transmission prevention studies. Cellular and humoral immune responses are seen in both the models. While there is efficient antigen specific IgM production, IgG responses are suboptimal due to inefficient immunoglobulin class switching. With the maturation of T cells occurring in the autologous human thymus, BLT mice permit human HLA restricted T cell responses in contrast to hu-HSC mice. However, the strength of the immune responses needs further improvement in both models to reach the levels seen in humans. The scope of hu-Mice use is further broadened by transplantation of additional tissues like human liver thus permitting immunopathogenesis studies on hepatotropic viruses such as HCV. Numerous studies that encompass antivirals, gene therapy, viral evolution, and the

  17. Investigation and Analysis on the Selecting and Obtaining Employment of New Generation Migrant workers——A case of Yudu County,Jiangxi Province

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The paper conducts an investigation on the new generation migrant workers in view of the selecting and obtaining employment of new generation migrant workers in industrial zone of Yudu County,Ganzhou Province during the period from June 23,2010 to June 27,2010.The basic situation of the selecting and obtaining employment of new generation migrant workers,the expectation and career goals is collected.The chief problems confronted by the selecting and obtaining employment of migrant workers are analyzed.The problems cover substandard employment of enterprises;unsatisfying working and living conditions of new generation migrant workers;the knowledge and technology of new generation migrant workers lag behind the demand of enterprises;the new generation migrant workers lack the spirit of bearing hardships and hard work;new generation migrant workers do not have clear career plan and their demands on studying and training are hard to be materialized;restricted by household registration system,the new generation migrant workers can not enter into their workplace.Countermeasures and suggestions on solving the selecting and obtaining of new generation migrant workers are put forward.Firstly,perfecting the relevant laws and regulations on labors and protecting the each item of labor economic rights of new generation migrant workers;secondly,intensifying vocational training and improving the competitiveness of new generation migrant workers;thirdly,paying attention to the political education and mental health education on new generation migrant workers and launching rich and colorful cultural activities;fourthly,reinforcing the human concern and right protection on new generation migrant workers to enhance their right to say;fifthly,intensifying the reform on household registration and accelerating the process of urbanization.

  18. Establishment of double channels by ureteroscope in the treatment of posterior completely urethral rupture%用输尿管镜建立双通道治疗后尿道完全断裂的临床疗效

    Institute of Scientific and Technical Information of China (English)

    王江

    2016-01-01

    目的:探讨急诊内镜下尿道会师术治疗后尿道完全断裂的临床疗效。方法:收治后尿道完全断裂患者5例,均使用输尿管镜建立双通道治疗,观察患者的手术时间、出血量、术后恢复情况。结果:5例患者均置管成功,无中转开放手术;手术时间10~60 min,平均28 min;出血20~200 mL,平均80 mL;术后留置尿管3~4周,1例发生尿道狭窄,经尿道扩张后,症状缓解,均无勃起功能障碍。结论:用输尿管镜建立双通道治疗后尿道完全断裂效果显著,安全性高,能够有效降低并发症发生率。%Objective:To explore the clinical curative effect of urethral realignment under emergency endoscopy in the treatment of posterior completely urethral rupture.Methods:5 patients with posterior completely urethral rupture were selected.They were given establishment of double channels by ureteroscope.The operation time,bleeding amount and postoperative recovery of patients were observed.Results:5 patients were catheter successfully without conversion to open surgery.The operation time was 10 to 60 minutes,and the average was 28 minutes.The bleeding was 20 to 200 mL,and the average was 80 mL.The postoperative indwelling catheter was 3 to 4 weeks.1 case had urethral stricture.After urethral dilatation,the symptoms were relief,and they were no erectile dysfunction.Conclusion:Establishment of double channels by ureteroscope in the treatment of posterior completely urethral rupture has a significant effect.The safety is high.It can effectively reduce the incidence of complications.

  19. Ureteroscopic Management of Bulbous Urethral Disruption Placing Catheter (Report of 13 Cases)%输尿管镜下尿道置管治疗尿道球部断裂疗效观察(附13例报告)

    Institute of Scientific and Technical Information of China (English)

    李宏岩; 李海; 张茁; 周裔

    2011-01-01

    Objective:To investigate the approach and safety of ureteroscopic management of bulbous urethral disruption placing catheter. Methods: 13 cases with bulbous urethral disruption were placed catheter via urethra u-sing ureteroscopy. Clinical data were analyzed retrospectively. Results: 11 of 13 cases obtained normal urination after extubation, one stage successful rate was 84. 61% (11/13). Better maximum flow rate of urine was(14. 7±3. 2)ml/s. And the average time for whole surgery was(17. 7±3. 2)min. Removing stricture and end to end reanasto-mosis was done in 1 cases after operation in 6 months(7. 69%). Conclusions:For some of the patients with bulbous urethral disruption ureteroscopic placing catheter appears to be efficacious and safe.%目的:探讨输尿管镜下尿道置管术治疗尿道球部断裂的方法与安全性.方法:回顾性分析应用输尿管镜下尿道置管术治疗前尿道断裂患者13例的临床资料.结果:拔管后正常排尿11例,一次性手术治愈占84.61%,最大尿流率(MFR)为(14.7±3.2)ml/ s,平均手术时间为(17.7±3.2)min;术后尿道出血2例,占15.38%;6个月年后因尿道狭窄行开放手术1例,占7.69%.结论:在有效地控制治疗适应证的前提下,输尿管镜下尿道置管术治疗尿道球部断裂是安全、有效的方法.

  20. 输尿管软镜在泌尿外科疾病诊断及治疗中的应用%Flexible Ureteroscopy in the Diagnosis and Treatment of Urinary System Diseases

    Institute of Scientific and Technical Information of China (English)

    田雨; 卢剑; 肖春雷; 马潞林; 田晓军; 侯小飞; 赵磊; 王国良; 洪锴

    2013-01-01

    目的 探讨输尿管软镜在泌尿外科疾病诊断及治疗中的应用. 方法 2007年4月~2012年3月我院应用输尿管软镜诊断和治疗21例上尿路疾病.术中全麻或硬膜外麻醉,截石位.输尿管硬镜探查至输尿管上段并留置导丝,置入软镜导入鞘,软镜探查输尿管上段、肾盂及各肾盏并处理结石.有输尿管皮肤造口的患者可直视下置入导丝,进软镜行探查术.输尿管狭窄,逆行探查困难者,可建立皮肾通道,使用软镜顺行探查. 结果 12例结石均一次碎石成功,未发生输尿管穿孔、撕脱等术中并发症,均无输血.4例术后出现发热,经抗炎对症处理后症状改善,无脓肾等严重术后并发症.术后第2天复查KUB平片,双J管无移位,3例在肾区或输尿管走行区可见颗粒状高密度影.1个月后复查B超,残留结石均自行排出.6例肾盂占位探查者,5例一次手术完成探查,l例第1次进镜困难,留置输尿管支架1个月后行二次手术,手术顺利.3例膀胱癌术后输尿管狭窄,其中l例经输尿管皮肤造口逆行进输尿管软镜,2例行经皮肤肾造瘘顺行进输尿管软镜,均在镜下完成探查,解除狭窄,手术满意. 结论 输尿管软镜具有安全、微创、灵活,可完整探查上尿路集合系统等优势,并可同时予以相应的治疗.%Objective To evaluate flexible ureteroscopy in the diagnosis and treatment of urinary system diseases. Methods A retrospective analysis of 21 cases of upper urinary tract diseases, which were diagnosed or treated by using flexible ureteroscopy in our hospital from April 2007 to March 2012. Under general or epidural anesthesia, in a lithotomy position, exploration up to the upper ureter was made with rigid ureteroscopy, a wire was then placed for introducing flexible ureteroscope for exploration of the upper ureter and renal pelvis and calices, as well as removing stones. In patients with a percutaneous fistula, the wire was placed under a direct

  1. Flexible magnetoimpedance sensor

    Energy Technology Data Exchange (ETDEWEB)

    Li, Bodong; Kavaldzhiev, Mincho N.; Kosel, Jürgen, E-mail: jurgen.kosel@kaust.edu.sa

    2015-03-15

    Flexible magnetoimpedance (MI) sensors fabricated using a NiFe/Cu/NiFe tri-layer on Kapton substrate have been studied. A customized flexible microstrip transmission line was employed to investigate the MI sensors's magnetic field and frequency responses and their dependence on the sensors's deflection. For the first time, the impedance characteristic is obtained through reflection coefficient analysis over a wide range of frequencies from 0.1 MHz to 3 GHz and for deflections ranging from zero curvature to a radius of 7.2 cm. The sensor element maintains a high MI ratio of up to 90% and magnetic sensitivity of up to 9.2%/Oe over different bending curvatures. The relationship between the curvature and material composition is discussed based on the magnetostriction effect and stress simulations. The sensor's large frequency range, simple fabrication process and high sensitivity provide a great potential for flexible electronics and wireless applications. - Highlights: • A flexible magnetoimpedance (MI) sensor is developed. • Studies are carried out using a flexible microstrip transmission line. • An MI ratio of up to 90% is obtained. • The effect of magnetostriction is studied.

  2. Split Stirling linear cryogenic cooler for a new generation of high temperature infrared imagers

    Science.gov (United States)

    Veprik, A.; Zechtzer, S.; Pundak, N.

    2010-04-01

    Split linear cryocoolers find use in a variety of infrared equipment installed in airborne, heliborne, marine and vehicular platforms along with hand held and ground fixed applications. An upcoming generation of portable, high-definition night vision imagers will rely on the high-temperature infrared detectors, operating at elevated temperatures, ranging from 95K to 200K, while being able to show the performance indices comparable with these of their traditional 77K competitors. Recent technological advances in industrial development of such high-temperature detectors initialized attempts for developing compact split Stirling linear cryogenic coolers. Their known advantages, as compared to the rotary integral coolers, are superior flexibility in the system packaging, constant and relatively high driving frequency, lower wideband vibration export, unsurpassed reliability and aural stealth. Unfortunately, such off-the-shelf available linear cryogenic coolers still cannot compete with rotary integral rivals in terms of size, weight and power consumption. Ricor developed the smallest in the range, 1W@95K, linear split Stirling cryogenic cooler for demanding infrared applications, where power consumption, compactness, vibration, aural noise and ownership costs are of concern.

  3. Accelerated development of Zr-containing new generation ferritic steels for advanced nuclear reactors

    Energy Technology Data Exchange (ETDEWEB)

    Tan, Lizhen [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Yang, Ying [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Sridharan, K. [Univ. of Wisconsin, Madison, WI (United States)

    2015-12-01

    The mission of the Nuclear Energy Enabling Technologies (NEET) program is to develop crosscutting technologies for nuclear energy applications. Advanced structural materials with superior performance at elevated temperatures are always desired for nuclear reactors, which can improve reactor economics, safety margins, and design flexibility. They benefit not only new reactors, including advanced light water reactors (LWRs) and fast reactors such as the sodium-cooled fast reactor (SFR) that is primarily designed for management of high-level wastes, but also life extension of the existing fleet when component exchange is needed. Developing and utilizing the modern materials science tools (experimental, theoretical, and computational tools) is an important path to more efficient alloy development and process optimization. The ultimate goal of this project is, with the aid of computational modeling tools, to accelerate the development of Zr-bearing ferritic alloys that can be fabricated using conventional steelmaking methods. The new alloys are expected to have superior high-temperature creep performance and excellent radiation resistance as compared to Grade 91. The designed alloys were fabricated using arc-melting and drop-casting, followed by hot rolling and conventional heat treatments. Comprehensive experimental studies have been conducted on the developed alloys to evaluate their hardness, tensile properties, creep resistance, Charpy impact toughness, and aging resistance, as well as resistance to proton and heavy ion (Fe2+) irradiation.

  4. Development of New Generation of Ceramics for Environmentally Focused Chemical Separations

    Science.gov (United States)

    Ramakrishnan, Girish

    of this thesis focuses on development of a new generation of ceramic membranes utilizing thermal spray techniques to produce highly scalable and extremely cost effective filtration membranes. Thermal spray method of membrane manufacturing has the advantage of economic scalability (up to tens of square meters) along with performance enhancement as compared to conventional wet casting process. In addition to developing a proof of concept for this approach, several strategies on how to improve ceramic membranes' performance via spraying process optimization are also described. Specifically, several thermal sprayed Alumina membrane samples were prepared by varying different process parameters. These samples were characterized using known techniques and subjected to permeability and size exclusion tests to correlate spraying parameters with membranes' performance. The membrane samples showed excellent clean water flux comparable to commercially available membranes and had rejection rates up to 96%. These results show that the membranes produced in this research achieve outstanding performance at a fraction of the cost of commercially produced membrane, enabling the use of membrane filtrations units in developing countries.

  5. Investigation and Analysis on the Selecting and Obtaining Employment of New Generation Migrant workers - A case of Yudu county, Jiangxi Province

    OpenAIRE

    Qin, Xiuqing; Hu, Qinglin

    2011-01-01

    The paper conducts an investigation on the new generation migrant workers in view of the selecting and obtaining employment of new generation migrant workers in industrial zone of Yudu County, Ganzhou Province during the period from June 23, 2010 to June 27, 2010. The basic situation of the selecting and obtaining employment of new generation migrant workers, the expectation and career goals is collected. The chief problems confronted by the selecting and obtaining employment of migrant worke...

  6. Flexible magnetoimpedance sensor

    KAUST Repository

    Li, Bodong

    2015-03-01

    Flexible magnetoimpedance (MI) sensors fabricated using a NiFe/Cu/NiFe tri-layer on Kapton substrate have been studied. A customized flexible microstrip transmission line was employed to investigate the MI sensors\\'s magnetic field and frequency responses and their dependence on the sensors\\'s deflection. For the first time, the impedance characteristic is obtained through reflection coefficient analysis over a wide range of frequencies from 0.1 MHz to 3 GHz and for deflections ranging from zero curvature to a radius of 7.2 cm. The sensor element maintains a high MI ratio of up to 90% and magnetic sensitivity of up to 9.2%/Oe over different bending curvatures. The relationship between the curvature and material composition is discussed based on the magnetostriction effect and stress simulations. The sensor\\'s large frequency range, simple fabrication process and high sensitivity provide a great potential for flexible electronics and wireless applications.

  7. Pneumatic flexible shaft couplings

    Directory of Open Access Journals (Sweden)

    Jaroslav HOMIŠIN

    2007-01-01

    Full Text Available Main effort of every design engineer is reduction of torsional oscillation in any mechanical system. At present this problem can be solved by means of a suitable modification of dynamic properties of flexible shaft couplings according to dynamics in the given systems. But the dynamic properties of nowadays-applied flexible couplings arenot unchangeable because of aging and fatigue processes occurring in flexible coupling elements. Result of this fact causes detuning of mechanical system. Taking into consideration the above-mentioned situation, we suggest for mechanical systems application of a newly developed pneumatic couplings that have constant characteristicfeatures during the whole current operation and thus they have a positive influence on the system running.

  8. Designing structural supply chain flexibility

    OpenAIRE

    Mulinski, Ksawery Jan

    2012-01-01

    In a continuously changing business environment the role of supply chain flexibility is constantly increasing. A flexible supply chain can ensure survival in quickly changing market conditions as well as enable sustainable growth. This thesis explores the topic of supply chain flexibility with focus on structural flexibility due to scarcity of previous research in that area. The purpose of the research is to answer a question: how can companies design structural supply chain flexibility? In a...

  9. Thin flexible intercalation anodes

    Energy Technology Data Exchange (ETDEWEB)

    Levy, S.C.; Cieslak, W.R.; Klassen, S.E.; Lagasse, R.R.

    1994-10-01

    Poly(acrylonitrile) fibers have been pyrolyzed under various conditions to form flexible carbon yarns capable of intercalating lithium ions. These fibers have also been formed into both woven and non woven cloths. Potentiostatic, potentiodynamic and galvanostatic tests have been conducted with these materials in several electrolytes. In some tests, a potential hold was used after each constant current charge and discharge. These tests have shown some of these flexible materials to reversibly intercalate lithium ions to levels that are suitable for use as a practical battery anode.

  10. Education Demand of New Generation Minority Migrant Workers in Kunming City and Survey of its Influence Factors

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Based on the questionnaire survey for 431 new generation minority migrant workers in Kunming City,we carried out empirical research on education demands of these migrant workers and its influence factors.Survey results show that their education demands have significant features in learning purposes,contents,expenses,willingness,and manners,which are subject to subjective mentality,economic income,social relation network,as well as shortage in social supply of education and training.Therefore,apart from solving training problem of new generation minority migrant workers,government should also highly value their demands of training and arouse their enthusiasm for participation in training in accordance with cultural and psychological characteristics and living environment of these migrant workers.

  11. BASIC PRINCIPLES OF ORGANIZING OF REPAIR OF A NEW GENERATION OF ELECTRIC POWER LINES 220 kV AND ABOVE

    Directory of Open Access Journals (Sweden)

    Postolaty V.M.

    2011-08-01

    Full Text Available The article describes the requirements for repair work on single circuit and double circuit overhead transmission lines of compact (VL and controlled self-compensating high voltage transmission power lines (CSHVL.These include overhead power lines to a new generation. They differ from traditional overhead using compact designs of supports, the convergence phase of the spans, circuits and substations connections to ways of regulation. With this new generation have the overhead compared to conventional overhead increased bandwidth and improved technical and economic indicators. The design and features of the new circuit overhead lines require a series of new campaigns for the organization of repairs, which are discussed in this article.

  12. Developing the concept of maintenance and repairs in projects of power units for new-generation nuclear power stations

    Science.gov (United States)

    Gurinovich, V. D.; Yanchenko, Yu. A.

    2012-05-01

    Results from conceptual elaboration of individual requirements for the system of maintenance and repairs that must be implemented in the projects of new-generation nuclear power stations are presented taking as an example the power unit project for a nuclear power station equipped with a standard optimized VVER reactor with enhanced information support (the so-called VVER TOI reactor). Implementation of these concepts will help to achieve competitiveness of such nuclear power stations in the domestic and international markets.

  13. A new generation of medium-voltage switchboards and circuit-breakers; Eine neue Generation von Mittelspannungsschaltanlagen und -leistungsschaltern

    Energy Technology Data Exchange (ETDEWEB)

    Saemann, D.; Weichert, R.; Werner, S. [Siemens AG, Erlangen (Germany). Bereich Energieuebertragung und -verteilung

    1998-04-06

    Todays market and the trend towards globalization of business both call for new products. The authors describe the new generation of medium-voltage switchgears and circuit-breakers, along with the benefit they bring for customers. (orig./RHM) [Deutsch] Der Markt und die Globalisierung des Geschaeftes fordern neue Produkte. Die Verfasser beschreiben die neue Generation von Mittelspannungsschaltanlagen und -schaltern sowie deren Nutzen fuer die Anwender. (orig./RHM)

  14. Conceptual study on a new generation of the high-innovative advanced porous and composite nanostructural functional materials with nanofibers

    OpenAIRE

    L.A. Dobrzański; M. Pawlyta; A. Hudecki

    2011-01-01

    Purpose: The purpose of the paper is to analyse theoretically the possibilities of the development of a new generation of the high-innovative advanced porous and composite nanostructural functional materials with nanofibers and to study into the material science grounds of synthesis and/or production and formulation of such materials’ structure and properties and to characterise and model their structure and properties depending on the compositional, phase and chemical composition and the app...

  15. Synthesis of a new generation of amphiphiles with multi-cryptand headgroups: A comparative study at air–water interface

    Indian Academy of Sciences (India)

    B Sarkar; R K Gupta; R A Singh; P K Bharadwaj

    2008-06-01

    A laterally non-symmetric aza cryptand has been derivatized with two hydrophobic chains to afford amphiphiles with one cryptand headgroup and two hydrophobic tails. Three such units readily attach to 1,3,5-benzenetricarbonyl trichloride, to form a new generation of amphiphilic molecules with three cryptand headgroups and six hydrophobic chains. These molecules are studied at the air–water interface in a Langmuir trough. They readily form LB-films on a number of substrates that are characterized.

  16. E-Tools for the disabled and for the new generation of senior citizens: a position paper

    OpenAIRE

    Cortés García, Claudio Ulises; Annicchiarico, Roberta; Vázquez Salceda, Javier; Sànchez-Marrè, Miquel; Marini, Andrea; Caltagirone, Carlo

    2002-01-01

    In this paper we present our exploratory ideas about the integration of agent technology with other technologies to build specific e-tools for the disabled and for the new generation of senior citizens. In particular, we like to explore the benefits of the concept of situated intelligence to build intelligent artifacts that will enhance the autonomy of the target group during their daily life.

  17. High Aspect Ratio Microstructures in Flexible Printed Circuit Boards : Process and Applications

    OpenAIRE

    Yousef, Hanna

    2008-01-01

    Flexible printed circuit boards (flex PCBs) are used in a wide range of electronic devices today due to their light weight, bendability, extensive wiring possibilities, and low-cost manufacturing techniques. The general trend in the flex PCB industry is further miniaturization alongside increasing functionality per device and reduced costs. To meet these demands, a new generation of low cost manufacturing technologies is being developed to enable structures with smaller lateral dimensions and...

  18. Flexible energy systems

    DEFF Research Database (Denmark)

    Lund, Henrik

    2003-01-01

    The paper discusses and analyses diffent national strategies and points out key changes in the energy system in order to achieve a system which can benefit from a high percentage of wind and CHP without having surplus production problems, introduced here as a flexible energy system....

  19. Flexible Classroom Furniture

    Science.gov (United States)

    Kim Hassell,

    2011-01-01

    Classroom design for the 21st-century learning environment should accommodate a variety of learning skills and needs. The space should be large enough so it can be configured to accommodate a number of learning activities. This also includes furniture that provides flexibility and accommodates collaboration and interactive work among students and…

  20. Flexible Language Interoperability

    DEFF Research Database (Denmark)

    Ekman, Torbjörn; Mechlenborg, Peter; Schultz, Ulrik Pagh

    2007-01-01

    of the language. In this paper, we present a highly flexible yet efficient approach to hosting multiple programming languages on an object-oriented virtual machine. Our approach is based on extending the interface of each class with language-specific wrapper methods, offering each language a tailored view...

  1. Flexible Mental Calculation.

    Science.gov (United States)

    Threlfall, John

    2002-01-01

    Suggests that strategy choice is a misleading characterization of efficient mental calculation and that teaching mental calculation methods as a whole is not conducive to flexibility. Proposes an alternative in which calculation is thought of as an interaction between noticing and knowledge. Presents an associated teaching approach to promote…

  2. Flexible cultural repertoires

    DEFF Research Database (Denmark)

    Lindegaard, Marie Rosenkrantz; Zimmermann, Francisca

    2017-01-01

    rejection of crime-involved youth. Young men who perform flexible cultural repertoires, by incorporating and shifting between gang and decent repertoires, experience low victimization due to their adaptation to crime-involved youth. Findings emphasize the importance of detailed investigations of the way...

  3. Flexible metal bellows

    CERN Multimedia

    1975-01-01

    A set of flexible metal bellows being fatigue-tested by repeated offset motion. Such bellows assemblies were used in the SPS vacuum system at places where , for instance, beam stoppers and collimators had to be moved frequently in and out of the beam path.

  4. Flexible Query Answering Systems

    DEFF Research Database (Denmark)

    This book constitutes the refereed proceedings of the 12th International Conference on Flexible Query Answering Systems, FQAS 2017, held in London, UK, in June 2017. The 21 full papers presented in this book together with 4 short papers were carefully reviewed and selected from 43 submissions...

  5. A New Generation of Micro Satellite Radiometers for Atmospheric Remote Sensing

    Science.gov (United States)

    He, jieying

    2017-04-01

    The need for low-cost, mission-flexible, and rapidly deployable space borne sensors that meet stringent performance requirements pervades the extreme weather monitoring programs, including especially the strong rainfall and typhoon. New technologies have enabled a novel approach toward this science observational goal, and in this paper we describe recent technology develop efforts to address the challenges above through the use of radiometers on a Micro-sized Microwave Atmospheric Satellite (Microsat), which operates in the type of constellation, and enable the capabilities of rapidly progressing. Recent work has involved the design and development of highly integrated radiometer component technologies that would enable the realization of a high-performance, multi-band sounder that would conform to the 3U CubeSat size (10 x 10 x 30 cm), weight, and power requirements. This paper partly focuses on the constellation to realize a scalable CubeSat-based system that will pave the path towards improved revisit rates over critical earth regions, and achieve state-of-the-art performance relative to current systems with respect to spatial, spectral, and radiometric resolution. As one of the important payloads on the platform, sub-millimeter radiometer is advised to house for providing atmospheric and oceanographic information all weather and all day. The first portion of the radiometer comprises a horn-fed reflector antenna, with a full-width at half-maximum (FWHM) beamwidth of 1.2°. Hence, the scanned beam has an approximate footprint diameter of 9.6 km at nadir incidence from a nominal altitude of 500 km. The antenna system is designed for a minimum 95% beam efficiency. Approximately 98 pixels are sampled for every scanning line, which covers a range of 1500km. The period of a round is about 94.47 minutes and re-visit period is four days. For the radiometer, which is a passive cross-track-scanning microwave spectrometer operating near the 118.75-GHz oxygen absorption

  6. New Generation Energy Efficient Refractory Application in Soaking Pits of Bhilai Steel Plant, Sail

    Science.gov (United States)

    Roy, Indranil; Chintaiah, Perumetla; Bhattacharya, Ajoy Kr.; Garai, Swapan Kr.; Ray Choudhury, Pankaj Kr.; Tiwari, Laksman

    In Bhilai Steel Plant (BSP), soaking pits are used for heating ingots for successive rolling into blooms. Pits are operated at a temperature of around 1350°C. Mixed gas (Mixture of Blast Furnace gas & Coke Oven gas) of calorific value around 2040 kcal/Nm3 is used as fuel. The walls of soaking pits were lined with traditional 38% Al2O3 firebricks and top 500mm was cast with 70% Al2O3 low cement castable (LCC). This type of lining results in frequent damages due to hitting by ingots while being lifted from pit by overhead cranes thus affecting the availability of pit. Life of pits was 2 to 2.5 years in BSP with 3-4 cold repairs and 3-4 hot repairs. Energy loss through the wall is also quite high in this type of lining. To triumph over the limitations of the conventional lining, a lining design was developed for the walls which consist of special 70% Al2O3 LCC having high hot strength (HMOR) in combination with specially design flexible SS-304 anchors. Ceramic fiber blanket and insulation bricks were provided between castable and the metallic shell of the pit to minimize the heat loss. A heating schedule was developed and introduced based on available infrastructure at BSP for proper curing of modified LCC based lining. After introduction of modified lining, pit no. 14/2 is running for more than 2.5 years without any repair. To capitalize the success, two more pits i.e. 12/1 and 9/2 were converted to modified lining. These pits are also running satisfactorily for more than 1.5 years. The modification has resulted in higher availability with substantial increase in production. Shell temperature of the modified pits reduced to 90° - 140°C from 120° - 200°C of conventional pits. This shows reduction in heat loss through walls, resulting less fuel consumption and energy saving of about 18%.

  7. Adding flexibility to physician training.

    Science.gov (United States)

    Mahady, Suzanne E

    2011-05-02

    Demographic changes among junior doctors are driving demand for increased flexibility in advanced physician training, but flexible training posts are lacking. Suitable flexible training models include flexible full-time, job-share and part-time positions. Major barriers to establishing flexible training positions include difficulty in finding job-share partners, lack of funding for creating supernumerary positions, and concern over equivalence of educational quality compared with full-time training. Pilot flexible training positions should be introduced across the medical specialties and educational outcomes examined prospectively.

  8. Aggregating energy flexibilities under constraints

    DEFF Research Database (Denmark)

    Valsomatzis, Emmanouil; Pedersen, Torben Bach; Abello, Alberto

    2016-01-01

    The flexibility of individual energy prosumers (producers and/or consumers) has drawn a lot of attention in recent years. Aggregation of such flexibilities provides prosumers with the opportunity to directly participate in the energy market and at the same time reduces the complexity of scheduling...... the energy units. However, aggregated flexibility should support normal grid operation. In this paper, we build on the flex-offer (FO) concept to model the inherent flexibility of a prosumer (e.g., a single flexible consumption device such as a clothes washer). An FO captures flexibility in both time...

  9. Evaluation of accelerated deterioration in NAPTF flexible test pavements

    Institute of Scientific and Technical Information of China (English)

    Kasthurirangan GOPALAKRISHNAN

    2008-01-01

    Previous research studies have successfully demonstrated the use of artificial neural network(ANN)models for predicting critical structural responses and layer moduli of highway flexible pavements.The primary objective of this study was to develop an ANN-based approach for backcalculation of pavement moduli based on heavy weight deflectometer(HWD)test data,especially in the analysis of airport flexible pavements subjected to new generation aircraft(NGA).Two medium-strength subgrade flexible test sections,at the National Airport Pavement Test Facility(NAPTF),were modeled using a finite element(FE) based pavement analysis program,which can consider the non-linear stress-dependent behavior of pavement geomaterials.A multi-layer,feed-forward network which uses an error-backpropagation algorithm was trained to approximate the HWD backcalculation function using the FE program generated synthetic database.At the NAPTF,test sections were subjected to Boeing 777 (B777)trafficking on one lane and Boeing 747(B747)trafficking on the other lane using a test machine.To monitor the effect of traffic and climatic variations on pavement structural responses.HWD tests were conducted on the traffieked lanes and on the untraffieked centerline of test sections as trafficking progressed.The trained ANN models were successfully applied on the actual HWD test data acquired at the NAPTF to predict the asphalt concrete moduli and non-1inear subgrade moduli of the medium-strength subgrade flexible test sections.

  10. FLEXIBLE GEIGER COUNTER

    Science.gov (United States)

    Richter, H.G.; Gillespie, A.S. Jr.

    1963-11-12

    A flexible Geiger counter constructed from materials composed of vinyl chloride polymerized with plasticizers or co-polymers is presented. The counter can be made either by attaching short segments of corrugated plastic sleeving together, or by starting with a length of vacuum cleaner hose composed of the above materials. The anode is maintained substantially axial Within the sleeving or hose during tube flexing by means of polystyrene spacer disks or an easily assembled polyethylene flexible cage assembly. The cathode is a wire spiraled on the outside of the counter. The sleeving or hose is fitted with glass end-pieces or any other good insulator to maintain the anode wire taut and to admit a counting gas mixture into the counter. Having the cathode wire on the outside of the counter substantially eliminates the objectional sheath effect of prior counters and permits counting rates up to 300,000 counts per minute. (AEC)

  11. Flexible Metasurface Holograms

    CERN Document Server

    Burch, James; Chen, Xianzhong; Di Falco, Andrea

    2016-01-01

    Metasurface holograms are typically fabricated on rigid substrates. Here we experimentally demonstrate broadband, flexible, conformable, helicity multiplexed metasurface holograms operating in the visible range, offering increased potential for real life out-of-the-lab applications. Two symmetrically distributed holographic images are obtained when circularly polarized light impinges on the reflective-type metasurface positioned on non- planar targets. The two off-axis images with high fidelity are interchangeable by controlling the helicity of incident light. Our metasurface features the arrangement of spatially varying gold nanorods on a flexible, conformable epoxy resist membrane to realize a Pancharatnam- Berry phase profile. These results pave the way to practical applications including polarization manipulation, beam steering, novel lenses, and holographic displays.

  12. Flexible Laser Metal Cutting

    DEFF Research Database (Denmark)

    Villumsen, Sigurd; Jørgensen, Steffen Nordahl; Kristiansen, Morten

    2014-01-01

    This paper describes a new flexible and fast approach to laser cutting called ROBOCUT. Combined with CAD/CAM technology, laser cutting of metal provides the flexibility to perform one-of-a-kind cutting and hereby realises mass production of customised products. Today’s laser cutting techniques...... possess, despite their wide use in industry, limitations regarding speed and geometry. Research trends point towards remote laser cutting techniques which can improve speed and geometrical freedom and hereby the competitiveness of laser cutting compared to fixed-tool-based cutting technology...... such as punching. This paper presents the concepts and preliminary test results of the ROBOCUT laser cutting technology, a technology which potentially can revolutionise laser cutting....

  13. Flexible training under threat.

    Science.gov (United States)

    Houghton, Anita; Eaton, Jennifer

    2002-10-01

    As the number of women in medicine and the general demand for a better work-life balance rises, flexible training is an increasingly important mechanism for maintaining the medical workforce. The new pay deal, together with entrenched cultural attitudes, are potential threats. Ways forward include more substantive part-time posts, more part-time opportunities at consultant level, and using positive experiences as a way of tackling attitudes in the less accepting specialties.

  14. Flexible Land Administration

    DEFF Research Database (Denmark)

    Enemark, Stig

    2014-01-01

    Security of tenure is widely considered to be the missing piece of the puzzle when it comes to eradication of poverty. And, as explained in the previous issue of Geoinformatics, the European Union is now placing land rights at the heart of EU development policy. This article presents a way forwar...... in terms of building flexible and "fit-for-purpose" land administration systems in developing countries. This will ensure security of tenure for all and sustainable management of the use of land....

  15. More flexibility for DESY

    CERN Multimedia

    2003-01-01

    In the future, budgeting at DESY will be more efficient. The 16 associated research centers are to be granted a wider margin in matters of finance and human resources. The Budget Committee of the German Bundestag has agreed to abstain from mandatory staff appointments. The current pre-determined "job pyramid" will be replaced by a more flexible mechanism, so that the conclusion of fixed labor contracts can more closely follow the needs of research (1 page).

  16. Industrial Fuel Flexibility Workshop

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2006-09-01

    On September 28, 2006, in Washington, DC, ITP and Booz Allen Hamilton conducted a fuel flexibility workshop with attendance from various stakeholder groups. Workshop participants included representatives from the petrochemical, refining, food and beverage, steel and metals, pulp and paper, cement and glass manufacturing industries; as well as representatives from industrial boiler manufacturers, technology providers, energy and waste service providers, the federal government and national laboratories, and developers and financiers.

  17. Flexible Land Administration

    DEFF Research Database (Denmark)

    Enemark, Stig

    2014-01-01

    Security of tenure is widely considered to be the missing piece of the puzzle when it comes to eradication of poverty. And, as explained in the previous issue of Geoinformatics, the European Union is now placing land rights at the heart of EU development policy. This article presents a way forwar...... in terms of building flexible and "fit-for-purpose" land administration systems in developing countries. This will ensure security of tenure for all and sustainable management of the use of land....

  18. Flexible Data Link

    Science.gov (United States)

    2015-04-01

    reconfiguring the waveform characteristics (on-the-fly) based on the engagement environment. Therefore, flexibility was the highest priority in the design of...the aircraft to a ground antenna . Utilizing the threshold system requirements (100 km range), we calculate the multipath of the aircraft as it...approaches the ground antenna . Figure 3: Multipath scenario #1 The calculation of the reflected path (denoted as A + C in Figure 3) is found through the

  19. Designing structural supply chain flexibility

    NARCIS (Netherlands)

    Mulinski, Ksawery Jan

    2012-01-01

    In a continuously changing business environment the role of supply chain flexibility is constantly increasing. A flexible supply chain can ensure survival in quickly changing market conditions as well as enable sustainable growth. This thesis explores the topic of supply chain flexibility with focus

  20. Flexible Scheduling: Making the Transition

    Science.gov (United States)

    Creighton, Peggy Milam

    2008-01-01

    Citing literature that supports the benefits of flexible scheduling on student achievement, the author exhorts readers to campaign for flexible scheduling in their library media centers. She suggests tips drawn from the work of Graziano (2002), McGregor (2006) and Stripling (1997) for making a smooth transition from fixed to flexible scheduling:…

  1. Designing structural supply chain flexibility

    NARCIS (Netherlands)

    Mulinski, Ksawery Jan

    2012-01-01

    In a continuously changing business environment the role of supply chain flexibility is constantly increasing. A flexible supply chain can ensure survival in quickly changing market conditions as well as enable sustainable growth. This thesis explores the topic of supply chain flexibility with focus

  2. MODELING THE ASIAN TSUNAMI EVOLUTION AND PROPAGATION WITH A NEW GENERATION MECHANISM AND A NON-LINEAR DISPERSIVE WAVE MODEL

    Directory of Open Access Journals (Sweden)

    Paul C. Rivera

    2006-01-01

    Full Text Available A common approach in modeling the generation and propagation of tsunami is based on the assumption of a kinematic vertical displacement of ocean water that is analogous to the ocean bottom displacement during a submarine earthquake and the use of a non-dispersive long-wave model to simulate its physical transformation as it radiates outward from the source region. In this study, a new generation mechanism and the use of a highly-dispersive wave model to simulate tsunami inception, propagation and transformation are proposed. The new generation model assumes that transient ground motion during the earthquake can accelerate horizontal currents with opposing directions near the fault line whose successive convergence and divergence generate a series of potentially destructive oceanic waves. The new dynamic model incorporates the effects of earthquake moment magnitude, ocean compressibility through the buoyancy frequency, the effects of focal and water depths, and the orientation of ruptured fault line in the tsunami magnitude and directivity.For tsunami wave simulation, the nonlinear momentum-based wave model includes important wave propagation and transformation mechanisms such as refraction, diffraction, shoaling, partial reflection and transmission, back-scattering, frequency dispersion, and resonant wave-wave interaction. Using this model and a coarse-resolution bathymetry, the new mechanism is tested for the Indian Ocean tsunami of December 26, 2004. A new flooding and drying algorithm that consider waves coming from every direction is also proposed for simulation of inundation of low-lying coastal regions.It is shown in the present study that with the proposed generation model, the observed features of the Asian tsunami such as the initial drying of areas east of the source region and the initial flooding of western coasts are correctly simulated. The formation of a series of tsunami waves with periods and lengths comparable to observations

  3. A new generation of versatile chromogenic substrates for high-throughput analysis of biomass-degrading enzymes

    DEFF Research Database (Denmark)

    Kracun, Stjepan Kresimir; Schückel, Julia; Westereng, Bjørge;

    2015-01-01

    Background: Enzymes that degrade or modify polysaccharides are widespread in pro- and eukaryotes and have multiple biological roles and biotechnological applications. Recent advances in genome and secretome sequencing, together with associated bioinformatic tools, have enabled large numbers...... of carbohydrate-acting enzymes to be putatively identified. However, there is a paucity of methods for rapidly screening the biochemical activities of these enzymes, and this is a serious bottleneck in the development of enzyme-reliant bio-refining processes. Results: We have developed a new generation of multi...... carbohydrate-acting enzymes, and the assays have the potential to be incorporated into fully or semi-automated robotic enzyme screening systems...

  4. Ureteroscopic holmium laser lithotripsy in treatment of patients with acute obstructive renal impairment%输尿管镜钬激光碎石术治疗急性梗阻性肾功能衰竭

    Institute of Scientific and Technical Information of China (English)

    段永顺; 倪少滨; 陈起引; 赵忠山

    2011-01-01

    目的 探讨上尿路结石引起的急性梗阻性肾衰的治疗方法.方法 采用输尿管镜直视下取石、钬激光碎石或将结石推入肾盂,体外冲击渡碎石(ESWL)治疗急性梗阻性肾衰32例(62侧).所有患者输尿管镜检查术前未曾放置输尿管支架或肾盂引流管.结果 30例输尿管中下段结石经输尿管镜直视下取碎石成功,碎石成功率93.7%.2例输尿管上段结石被推入肾盂,行ESWL治疗后1个月,结石排净.术后患者肾功能恢复正常或接近正常,尿量恢复,结石排净率100%.结论 输尿管镜下取石、钬激光碎石治疗结石引起的急性梗阻性肾衰是一种安全、有效、创伤小、术后恢复快且可同时处理双侧输尿管的手术方式,可作为上尿路梗阻并发急性肾功能衰竭的首选治疗方法.%Objective To evaluate the efficacy and safety of holmium laser for treatment ureteric stones in patients with acute obstructive renal impairment.Methods Thirty-two patients were included in this study.None of the patients had a ureterie stent or nephrostomy tube before the ureteroseopy.All patients were treated with holmium laser.Results 30 patients with ureter stones in middle and inferior segment were free of stones by ureteroscopic lithotripsy.The success rate for treatment of ureteral stones lithotripsy and calculus removal was 93.7%.Ureter stones located in superior segment in two patients were sent back pelvis.Extracorporeal shock-wave lithotripsy were performed.The two patients were free of any stone fragmens a month later.In all patients, including the five with obstructive anuria,the renal impairment resolved or improved as evidenced by normalization or fall in blood urea and creatinine.100% of the patients were free of any stone fragments postoperatively.Conclusion A holmium laser was a safe and effective modality of ureteroscopic lithotripsy in patients with significant renal impairment or even obstructive anuria.It also had merits of small

  5. 输尿管软镜钬激光碎石术治疗上尿路结石疗效分析%Application of flexible ureteroscopy in treatment of upper urinary tract stones

    Institute of Scientific and Technical Information of China (English)

    郝宗耀; 刘明; 樊松; 张贤生; 施浩强; 周骏; 梁朝朝

    2016-01-01

    Objective To evaluate the safety and efficacy of flexible ureteroscopic technology in the treatment of upper urinary tract stones .Methods A retrospective analysis was performed in 131 cases diagnosed with upper urinary tract stones using flexible ureteroscope . Results All 130 cases accepted holmium laser lithotripsy .No significant residual stones were found in 126 cases(96.9%).The mean op-erative time was 30~150 min,and the mean postoperative hospital stay was 2d.No ureteral perforation ,avulsion,severe bleeding ,urosepsis and other serious complications appeared .Conclusion The flexible ureteroscopy for diagnosis and treatment of upper urinary tract diseases is safe and effective ,especially for failure of extracorporeal shock wave lithotripsy or high -risk of percutaneous nephrolithotomy ,which could be used as one of the preferred clinical treatment options .%目的 探讨输尿管软镜钬激光碎石术治疗上尿路结石的疗效.方法 回顾性分析131例上尿路结石患者应用输尿管软镜钬激光碎石术的治疗效果.结果 130例患者顺利完成输尿管软镜钬激光碎石术,术后复查无明显结石残余126例(96.9%),手术时间为30~150 min,术后平均住院天数为2 d.未出现输尿管穿孔、撕脱、大出血、脓毒血症等严重并发症.结论 输尿管软镜钬激光碎石术对上尿路结石的诊治是安全、有效的,尤其对于体外冲击波碎石失败或经皮肾镜取石困难的上尿路结石的治疗有独特优势,可作为临床首选治疗方法之一.

  6. Measuring and Comparing Energy Flexibilities

    DEFF Research Database (Denmark)

    Valsomatzis, Emmanouil; Hose, Katja; Pedersen, Torben Bach

    2015-01-01

    Flexibility in energy supply and demand becomes more and more important with increasing Renewable Energy Sources (RES) production and the emergence of the Smart Grid. So-called prosumers, i.e., entities that produce and/or consume energy, can offer their inherent flexibilities through so......-called demand response and thus help stabilize the energy markets. Thus, prosumer flexibility becomes valuable and the ongoing Danish project TotalFlex [1] explores the use of prosumer flexibility in the energy market using the concept of a flex-offer [2], which captures energy flexibilities in time and...... induced by time and amount individually, and by their com- bination. To this end, we introduce several flexibility measures that take into account the combined effect of time and energy on flex-offer flexibility and discuss their respective pros and cons through a number of realistic examples....

  7. METHODICAL APPROACHES TO THE CHOICE OF THE NEW GENERATION OF HIGH-VOLTAGE POWER TRANSMISSION LINE 220 kV OPTIONS

    Directory of Open Access Journals (Sweden)

    POSTOLATI V.M.

    2010-08-01

    Full Text Available The Transmission Power Lines of new generation are described in the article (single- compact, double-circuit compact, double-circuit Controlled Self-compensating High Voltage Transmission Power Lines (CSHVL. Basic principles of creation, design elements and comparative characteristics of the transmission lines of the new generation are described, the advantages of its are showed. Methodical approaches to the choosing of a new generation of transmission lines and facilities management FACTS are formulated. Methodical approaches to the choice of options for transmission lines 220 kV and facilities management are shown.

  8. Flexible Volumetric Structure

    Science.gov (United States)

    Cagle, Christopher M. (Inventor); Schlecht, Robin W. (Inventor)

    2014-01-01

    A flexible volumetric structure has a first spring that defines a three-dimensional volume and includes a serpentine structure elongatable and compressible along a length thereof. A second spring is coupled to at least one outboard edge region of the first spring. The second spring is a sheet-like structure capable of elongation along an in-plane dimension thereof. The second spring is oriented such that its in-plane dimension is aligned with the length of the first spring's serpentine structure.

  9. Flexible composite radiation detector

    Science.gov (United States)

    Cooke, D. Wayne; Bennett, Bryan L.; Muenchausen, Ross E.; Wrobleski, Debra A.; Orler, Edward B.

    2006-12-05

    A flexible composite scintillator was prepared by mixing fast, bright, dense rare-earth doped powdered oxyorthosilicate (such as LSO:Ce, LSO:Sm, and GSO:Ce) scintillator with a polymer binder. The binder is transparent to the scintillator emission. The composite is seamless and can be made large and in a wide variety of shapes. Importantly, the composite can be tailored to emit light in a spectral region that matches the optimum response of photomultipliers (about 400 nanometers) or photodiodes (about 600 nanometers), which maximizes the overall detector efficiency.

  10. Composite Flexible Blanket Insulation

    Science.gov (United States)

    Kourtides, Demetrius A. (Inventor); Pitts, William C. (Inventor); Goldstein, Howard E. (Inventor); Sawko, Paul M. (Inventor)

    1991-01-01

    Composite flexible multilayer insulation systems (MLI) were evaluated for thermal performance and compared with the currently used fibrous silica (baseline) insulation system. The systems described are multilayer insulations consisting of alternating layers of metal foil and scrim ceramic cloth or vacuum metallized polymeric films quilted together using ceramic thread. A silicon carbide thread for use in the quilting and the method of making it are also described. These systems are useful in providing lightweight insulation for a variety of uses, particularly on the surface of aerospace vehicles subject to very high temperatures during flight.

  11. Flexible plasma linear antenna

    Science.gov (United States)

    Zhao, Jiansen; Wang, Shengzheng; Wu, Huafeng; Liu, Yue; Chang, Yongmeng; Chen, Xinqiang

    2017-02-01

    In this work, we introduce a type of plasma antenna that was fabricated using flexible materials and excited using a 5-20 kHz alternating current (ac) power supply. The results showed that the antenna characteristics, including the impedance, the reflection coefficient (S11), the radiation pattern, and the gain, can be controlled rapidly and easily by varying both the discharge parameters and the antenna shapes. The scope for reconfiguration is greatly enhanced when the antenna shape is changed from a monopole to a helix configuration. Additionally, the antenna polarization can also be adjusted by varying the antenna shapes.

  12. Asymmetric Flexible Supercapacitor Stack

    Directory of Open Access Journals (Sweden)

    Leela Mohana Reddy A

    2008-01-01

    Full Text Available AbstractElectrical double layer supercapacitor is very significant in the field of electrical energy storage which can be the solution for the current revolution in the electronic devices like mobile phones, camera flashes which needs flexible and miniaturized energy storage device with all non-aqueous components. The multiwalled carbon nanotubes (MWNTs have been synthesized by catalytic chemical vapor deposition technique over hydrogen decrepitated Mischmetal (Mm based AB3alloy hydride. The polymer dispersed MWNTs have been obtained by insitu polymerization and the metal oxide/MWNTs were synthesized by sol-gel method. Morphological characterizations of polymer dispersed MWNTs have been carried out using scanning electron microscopy (SEM, transmission electron microscopy (TEM and HRTEM. An assymetric double supercapacitor stack has been fabricated using polymer/MWNTs and metal oxide/MWNTs coated over flexible carbon fabric as electrodes and nafion®membrane as a solid electrolyte. Electrochemical performance of the supercapacitor stack has been investigated using cyclic voltammetry, galvanostatic charge-discharge, and electrochemical impedance spectroscopy.

  13. Review of new generation smart substation technology%新一代智能变电站技术综述

    Institute of Scientific and Technical Information of China (English)

    唐卫华; 杨俊武; 欧阳帆

    2015-01-01

    本文围绕新一代智能变电站技术展开综述. 首先描述智能变电站的现状; 介绍新一代智能变电站的定义, 逐项分析新一代智能变电站的重要技术特征, 包括一次电气方面主接线优化和新型隔离断路器应用、 二次设备的层次化保护控制系统、 模块化二次设备、 一二次设备集成等; 最后对上述技术特征和其实际应用情况进行小结, 认为新一代智能变电站技术是在原有智能变电站技术基础上的提升, 但其应用技术的成熟还需要一段时间的磨练, 对技术人员在吸收新技术方面提出了相应要求.%This paper focuses on the new generation smart substation technology. The present situation of the smart substation are summarized firstly. Then the definition of new generation smart substation is introduced and the important technical features are analyzed in details afterwards, including the optimization of main electrical wiring and the application of new disconnecting circuit-breakers, the hierarchical protection system for secondary equipment, the modular secondary equipment, the integration of primary and secondary equipment. At last, the paper makes a summary of the technical features and its practical application. It is believed that the new generation of smart substation technology is based on the original smart substation technology, but the mature application of the technology also need times, and it puts forward new requirements for the operator in technical level and operation ability.

  14. The effect of a new-generation flowable composite resin on microleakage in Class V composite restorations as an intermediate layer

    Directory of Open Access Journals (Sweden)

    Soley Arslan

    2013-01-01

    Conclusions: Micro-leakage is not affected by the application of either conventional or new-generation flowable composite resin as an intermediate material between composite resin and dental substrates.

  15. The Flexibility Hypothesis of Healing.

    Science.gov (United States)

    Hinton, Devon E; Kirmayer, Laurence J

    2017-03-01

    Theories of healing have attempted to identify general mechanisms that may work across different modalities. These include altering expectations, remoralization, and instilling hope. In this paper, we argue that many forms of healing and psychotherapy may work by inducing positive psychological states marked by flexibility or an enhanced ability to shift cognitive sets. Healing practices may induce these states of cognitive and emotional flexibility through specific symbolic interventions we term "flexibility primers" that can include images, metaphors, music, and other media. The flexibility hypothesis suggests that cognitive and emotional flexibility is represented, elicited, and enacted through multiple modalities in healing rituals. Identifying psychological processes and cultural forms that evoke and support cognitive and emotional flexibility provides a way to understand the cultural specificity and potential efficacy of particular healing practices and can guide the design of interventions that promote resilience and well-being.

  16. Peopling an Unaccustomed Earth with a New Generation: Jhumpa Lahiri’s Supreme Fictional Journey into Human Conditions

    Directory of Open Access Journals (Sweden)

    Neela Bhattacharya SAXENA

    2012-06-01

    Full Text Available Using a theoretical framework derived from my ongoing engagement with what I havecalled a ‘Gynocentric matrix’ of Indic sensibility, along with James Hillman’s polytheisticpsychology and Wallace Stevens’ notion of a Supreme Fiction, this paper offers a readingof Jhumpa Lahiri’s (b. 1967 short stories beyond postcolonial criticism. Stemming froma depth consciousness where life, living and death, joy, indifference and sorrow, generation, de/re-generation, and transformation are intricately intertwined, Lahiri’s fictionalmultiverse is peopled by a new generation of characters who speak to the soul of the reader; in the process, she sculpts a reality that does not tolerate any homogenizing impulse in the name of an abstract unity.

  17. Sustainable production of a new generation biofuel by lipase-catalyzed esterification of fatty acids from liquid industrial waste biomass.

    Science.gov (United States)

    Foukis, Athanasios; Gkini, Olga A; Stergiou, Panagiota-Yiolanda; Sakkas, Vasilios A; Dima, Agapi; Boura, Konstantina; Koutinas, Athanasios; Papamichael, Emmanuel M

    2017-08-01

    In this work we suggest a methodology comprising the design and use of cost-effective, sustainable, and environmentally friendly process for biofuel production compatible with the market demands. A new generation biofuel is produced using fatty acids, which were generated from acidogenesis of industrial wastes of bioethanol distilleries, and esterified with selected alcohols by immobilized Candida antarctica Lipase-B. Suitable reactors with significant parameters and conditions were studied through experimental design, and novel esterification processes were suggested; among others, the continuous removal of the produced water was provided. Finally, economically sustainable biofuel production was achieved providing high ester yield (<97%) along with augmented concentration (3.35M) in the reaction mixtures at relatively short esterification times, whereas the immobilized lipase maintained over 90% of its initial esterifying ability after reused for ten cycles. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Study of Green Shipping Technologies - Harnessing Wind, Waves and Solar Power in New Generation Marine Propulsion Systems

    Directory of Open Access Journals (Sweden)

    Grzegorz Rutkowski

    2016-12-01

    Full Text Available The purpose and scope of this paper is to describe the complexity of the new generation marine propulsion technologies implemented in the shipping industry to promote green ships concept and change the view of sea transportation to a more ecological and environment-friendly. Harnessing wind, waves and solar power in shipping industry can help the ship’s owners reduce the operational costs. Reducing fuel consumption results in producing less emissions and provides a clean source of renewable energy. Green shipping technologies can also effectively increase the operating range of vessels and help drive sea transportation towards a greener future and contribute to the global reduction of harmful gas emissions from the world's shipping fleets.

  19. Counting rate measurements for lifetime experiments using the RDDS method with the new generation γ-ray array AGATA

    Energy Technology Data Exchange (ETDEWEB)

    Goasduff, A., E-mail: Alain.Goasduff@csnsm.in2p3.fr [Université de Strasbourg, IPHC, 23 rue du Loess, F-67037 Strasbourg (France); CNRS, UMR 7178, F-67037 Strasbourg (France); CSNSM, UMR 8609, IN2P3-CNRS, Université Paris-Sud 11, F-91405 Orsay Cedex (France); Valiente-Dobón, J.J. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, I-35020 Legnaro (Italy); Lunardi, S. [Dipartimento di Fisica e Astronomia, Università di Padova and INFN, Sezione di Padova, I-35131 Padova (Italy); Haas, F. [Université de Strasbourg, IPHC, 23 rue du Loess, F-67037 Strasbourg (France); CNRS, UMR 7178, F-67037 Strasbourg (France); Gadea, A. [Instituto de Física Corpuscular, CSIC-Universitat de València, E-46980 Valencia (Spain); Angelis, G. de [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, I-35020 Legnaro (Italy); Bazzacco, D. [Dipartimento di Fisica e Astronomia, Università di Padova and INFN, Sezione di Padova, I-35131 Padova (Italy); Courtin, S. [Université de Strasbourg, IPHC, 23 rue du Loess, F-67037 Strasbourg (France); CNRS, UMR 7178, F-67037 Strasbourg (France); Farnea, E. [Dipartimento di Fisica e Astronomia, Università di Padova and INFN, Sezione di Padova, I-35131 Padova (Italy); Gottardo, A. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, I-35020 Legnaro (Italy); Michelagnoli, C. [Dipartimento di Fisica e Astronomia, Università di Padova and INFN, Sezione di Padova, I-35131 Padova (Italy); and others

    2014-09-11

    The differential Recoil Distance Doppler Shift (RDDS) method after multinucleon transfer (MNT) reactions to measure lifetimes of excited states in neutron-rich nuclei requires the use of a thick energy degrader for the recoiling ejectiles that are then detected in a spectrometer. This type of measurements greatly benefits from the use of the new generation segmented γ-ray detectors, such as the AGATA demonstrator which offers unprecedented energy and angular resolutions. In order to make an optimized choice of the material and the thickness of the degrader for lifetime measurements using the RDDS method after MNT, an experiment has been performed with the AGATA demonstrator. Counting rate measurements for different degraders are presented.

  20. New generation of membrane efficient water-based drilling fluids: pragmatic and cost-effective solutions to borehole stability problems

    Energy Technology Data Exchange (ETDEWEB)

    Tare, U.A. [Haliburton, Calgary, AB (Canada); Mody, F.K. [Shell International E and P Inc., Calgary, AB (Canada); Tan, C.P. [CSIRO Petroleum, Kensington, WA (Australia)

    2002-06-01

    Drilling and completion operations in shales often suffer as a result of wellbore instability. Mechanical failure of the rock around a wellbore is the primary cause of shale instability. This process can be exacerbated by physico-chemical interactions between drilling fluids and shales. Water-based drilling fluids are used more and more due to environmental awareness that becomes more prevalent. Wellbore instability problems can however result from an improper application of water-based drilling fluids in those cases where drilling occurs in sensitive clay-rich formations. To meet the requirements of the petroleum industry, considerable collaborative efforts were expanded in the development of innovative environmentally acceptable water-based drilling fluids. In this paper, the authors describe the process that leads to the development of these drilling fluids. It is possible to achieve shale stability through an osmotic outflow of pore fluid and prevention/minimization of mud pressure penetration, as laboratory experiments on shale samples under realistic downhole conditions exposed to these drilling fluids prove. High membrane efficiencies, in excess of 80 per cent, were generated by this new generation of membrane efficient water-based drilling fluids. Drilling objectives resulting from an improved application of water-based drilling fluids are made possible by a fundamental understanding of the main drilling fluid-shale interaction mechanisms for shale stability and the application of experimental data to field conditions. The authors indicate that the achievement of trouble-free drilling of shales and notable reductions in non-productive time is accomplished by following the practical guidelines included in this paper for maintaining shale stability with the new generation of water-based drilling fluids. 8 refs., 2 tabs., 4 figs.

  1. INFLUENCE OF THE PREPARATION CASLLED “VYMPEL” AND MINERAL FERTILIZERS OF NEW GENERATION ON OF SAPERAVI VARIETY

    Directory of Open Access Journals (Sweden)

    Kulyko I. A.

    2015-09-01

    Full Text Available The article presents the results of the studies on the effect of the processing of grape variety Saperavi with a growth regulator called Vimpel with water soluble and foliar fertilizers of new generation - Nutrivant plus and Kelik potassium silicon, both in pure form and in a tank mixture. Processing of bushes was performed three times: after flowering, growth phase of berries (berry of a pea, the beginning of ripening berries. We used Vimpel drug and foliar fertilizers such as Nutrivant plus and Kelik potassium-silicon, both in pure form and in conjunction with Vimpel; it led to a significant increase in weight of the bunch, bush crop and planting yields. The smallest yield increase was provided by Vimpel. However, the combined use of this drug on a background of Kelik silicon- potassium foliar fertilizer and Nutrivant plus led to a greater increase in yield from the bush than when used fertilizers only. Processing of bushes by Vimpel in combination with a foliar application of Kelik potassium-silicon not only led to a significant increase in crop yields from the bush and plantations, but in two cases of the three it contributed to a significant increase of the mass concentration of sugars in the juice of berries. Using Vimpel, together with Nutrivant plus foliar application for two years out of three promoted maximize yields (23.4 and 18.4% with a decrease in sugar content, and in one year - an increase in the harvest of 10.4%, with a significant increase in mass sugar concentration (1.92 g / 100 cm3 or 9.2%. Thus, the processing of Saperavi grapes with a growth regulator called Vimpel and water soluble foliar fertilizers of new generation - Nutrivant plus and Kelik potassium and silicon is an effective method of increasing the yield and quality of Saperavi grapes

  2. Synergistic Cytotoxicity of Melatonin and New-generation Anticancer Drugs Against Leukemia Lymphocytes But Not Normal Lymphocytes.

    Science.gov (United States)

    Zhelev, Zhivko; Ivanova, Donika; Bakalova, Rumiana; Aoki, Ichio; Higashi, Tatsuya

    2017-01-01

    The present study demonstrates specific sensitization of leukemia lymphocytes towards anticancer drugs using melatonin and clarifies the role of reactive oxygen species (ROS) for induction of apoptosis. The study covers four conventional and 11 new-generation anticancer drugs. Four parameters were analyzed simultaneously in leukemia and normal lymphocytes treated with drug, melatonin, or their combination: cell viability, induction of apoptosis, level of reactive oxygen species (ROS), and level of protein-carbonyl products. Almost all investigated combinations of melatonin with new-generation anticancer drugs were characterized by synergistic cytotoxicity towards leukemia lymphocytes, while the combinations with conventional drugs exhibited additive or antagonistic effects on cell viability. In leukemia lymphocytes, the additive cytotoxicity of doxorubicin plus melatonin was accompanied by low levels of ROS and protein-carbonyl products, as well as by suppression of apoptosis. In normal lymphocytes, none of the studied parameters changed significantly compared to cells treated with doxorubicin only. The combinations of everolimus plus melatonin and barasertib plus melatonin exhibited impressive synergistic cytotoxic effects on leukemia lymphocytes but did not affect the viability of normal lymphocytes. In leukemia cells, the synergistic cytotoxicity was accompanied by strong induction of apoptosis but a decrease of ROS to a level below that of the control. In normal lymphocytes, these combinations did not affect the level of ROS nor of protein-carbonyl products, and did not induce apoptosis. The data suggest that melatonin is a promising supplementary component in chemotherapy which allows the therapeutic doses of anticancer drugs to be reduced, minimizing their side-effects.

  3. Conceptual study on a new generation of the high-innovative advanced porous and composite nanostructural functional materials with nanofibers

    Directory of Open Access Journals (Sweden)

    L.A. Dobrzański

    2011-12-01

    Full Text Available Purpose: The purpose of the paper is to analyse theoretically the possibilities of the development of a new generation of the high-innovative advanced porous and composite nanostructural functional materials with nanofibers and to study into the material science grounds of synthesis and/or production and formulation of such materials’ structure and properties and to characterise and model their structure and properties depending on the compositional, phase and chemical composition and the applied synthesis and/or production and/or processing processes, without the attitude towards any direct practical application or use, but with confirming the highly probable future application areas, using the unexpected effects of formulating such materials’ functional properties.Design/methodology/approach: In general, the study is of priority cognitive importance as theoretical considerations and the author’s initial analyses related to technology foresight concerning this group of issues as well as sporadical results of research provided in the literature, usually in its incipient phase, indicating a great need to intensify scientific research, to develop the new groups of materials with quite unexpected predictable effects, resulting from the use of nanofibers for fabricating super advanced composite and porous materials.Findings: The description of the state of the art for the subject of the study has been limited to the issues initially selected with an analysis with the method of weighted scores.Practical implications: The outcoming materials may have direct influence on the development of electronics and photonics, medicine and pharmacy, environmental protection, automotive industry, space industry, machine industry, textile and clothing industry, cosmetic industry, agriculture and food sector.Originality/value: The value of this paper lies in the fact that it proposes a new generation of the high-innovative advanced porous and composite

  4. Flexible cultural repertoires

    DEFF Research Database (Denmark)

    Lindegaard, Marie Rosenkrantz

    2016-01-01

    Despite extensive studies of street culture and the risks of offending and victimization in urban marginalized areas, little is known about the role of cultural repertoires for variation in victimization risks among young men not involved in crime. Based on two ethnographic studies, conducted...... varying cultural repertoires, in particularly heterogeneous flexible repertoires, influence offending and victimization patterns among young men in high-risk settings....... independently of the authors in neighbouring township areas of Cape Town, we offer insights into patterns of victimization among young men not involved in crime who live and attend school in the townships. Young men who perform decent cultural repertoires are highly exposed to victimization due to their moral...

  5. Conformational flexibility of aspartame.

    Science.gov (United States)

    Toniolo, Claudio; Temussi, Pierandrea

    2016-05-01

    L-Aspartyl-L-phenylalanine methyl ester, better known as aspartame, is not only one of the most used artificial sweeteners, but also a very interesting molecule with respect to the correlation between molecular structure and taste. The extreme conformational flexibility of this dipeptide posed a huge difficulty when researchers tried to use it as a lead compound to design new sweeteners. In particular, it was difficult to take advantage of its molecular model as a mold to infer the shape of the, then unknown, active site of the sweet taste receptor. Here, we follow the story of the 3D structural aspects of aspartame from early conformational studies to recent docking into homology models of the receptor. © 2016 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 106: 376-384, 2016.

  6. A new robot for flexible ureteroscopy: development and early clinical results (IDEAL stage 1-2b).

    Science.gov (United States)

    Saglam, Remzi; Muslumanoglu, Ahmet Yaser; Tokatlı, Zafer; Caşkurlu, Turhan; Sarica, Kemal; Taşçi, Ali İhsan; Erkurt, Bülent; Süer, Evren; Kabakci, Ahmet Sinan; Preminger, Glenn; Traxer, Olivier; Rassweiler, Jens J

    2014-12-01

    An improved armamentarium has had a significant impact on the emerging role of flexible ureteroscopy (FURS) for the management of nephrolithiasis; however, FURS still represents a challenging technique. To examine a robotic device designed for FURS for its impact on ergonomics and outcome of the procedure based on the IDEAL (idea, development, evaluation, assessment, long-term study) framework. Roboflex Avicenna consists of a surgeon's console and a manipulator for the flexible ureterorenoscope. Following experimental evaluation of the prototype (IDEAL stage 1) and receipt of ethical approval, seven surgeons treated 81 patients (mean age: 42 yr [range: 6-68]) with renal calculi (mean volume: 1296±544 mm(3) [range: 432-3100 mm3]) in an observational study (IDEAL stage 2). Robotic FURS was performed with the Roboflex Avicenna robotic device. Numerical data were analysed with the Mann-Whitney test, and categorical variables were analysed using the chi-square test or Fisher exact test. P values <0.05 were considered statistically significant. Mean robot docking time was 59.6±45 s. Mean operative time was 74min (range: 40-182). Mean fragmentation speed was 29.1±6.1 mm3/min. Ergonomics based on a validated questionnaire showed significant advantage for robotic FURS (total score: 5.6 vs 31.3; p<0.01). A 10/12F-access sheath was used in 72 patients. Two cases required secondary FURS, one because of malfunction of the flexible digital ureteroscope and another because of larger residual fragments. In the remaining 79 cases, complete stone disintegration was accomplished. Roboflex Avicenna provides a suitable and safe platform for robotic FURS with significant improvement of ergonomics. Future studies should evaluate its impact on the clinical outcome of FURS. Robotic flexible ureteroscopy (FURS) was performed with the Roboflex Avicenna robotic device. Results showed that Roboflex Avicenna provides a suitable and safe platform for robotic FURS with significant improvement

  7. Building Highly Flexible Polyelectrolyte Nanotubes

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Flexibility of polyelectrolyte nanotubes is necessary if they are to be exploited in applications such as developing photoelectric devices with strong mechanical properties. In a recent attempt, high flexibility has been observed from such nanotubes prepared by a research team headed by Prof. Li Junbai of the CAS Institute of Chemistry (ICCAS).

  8. On flexible and rigid nouns

    DEFF Research Database (Denmark)

    Rijkhoff, Jan

    2008-01-01

    , Non-Verb, Modifier), there are also flexible word classes within the rigid lexical category Noun (Set Noun, Sort Noun, General Noun). Members of flexible word classes are characterized by their vague semantics, which in the case of nouns means that values for the semantic features Shape...

  9. On flexible and rigid nouns

    DEFF Research Database (Denmark)

    Rijkhoff, Jan

    2010-01-01

    This article argues that in addition to the major flexible lexical categories in Hengeveld’s classification of parts of speech systems (Contentive, Non-Verb, Modifier), there are also flexible word classes within the rigid lexical category Noun (Set Noun, Sort Noun, General Noun). Members...

  10. Function Machines & Flexible Algebraic Thought.

    Science.gov (United States)

    Davis, Gary E.; McGowen, Mercedes A.

    This paper explores how college students understand ideas of functions, and which representations are productive for them in promoting their ability to work flexibly across representations. The study used pre- and post-test scores, and triangulations via student self evaluations, to generate a hypothesis related to flexible thinking and success in…

  11. Sensor Technologies on Flexible Substrates

    Science.gov (United States)

    Koehne, Jessica

    2016-01-01

    NASA Ames has developed sensor technologies on flexible substrates integrated into textiles for personalized environment monitoring and human performance evaluation. Current technologies include chemical sensing for gas leak and event monitoring and biological sensors for human health and performance monitoring. Targeted integration include next generation EVA suits and flexible habitats.

  12. Retirement Flexibility and Portfolio Choice

    NARCIS (Netherlands)

    Adema, Y.; Bonenkamp, J.; Meijdam, A.C.

    2011-01-01

    This paper explores the interaction between retirement flexibility and portfolio choice in an overlapping-generations model. We analyse this interaction both in a partial-equilibrium and general-equilibrium setting. Retirement flexibility is often seen as a hedge against capital-market risks which

  13. Flexible Coupling Corrects Shaft Misalinements

    Science.gov (United States)

    Mayo, R. A.

    1983-01-01

    Proposed flexible coupling provides nearly error free measurements of shaft rotation in presence of misalinements between shaft and position sensing transducer. Intended to be used in situations in which input or output shaft is mounted on flexible joint. Its function is to insure equal input and output angular velocities by forcing input and output shafts to remain parallel.

  14. Dimension Analysis on Human Capital of the New Generation of Migrant Workers%新生代农民工人力资本的维度分析

    Institute of Scientific and Technical Information of China (English)

    刘万云

    2011-01-01

    运用人力资本理论研究新生代农民工的生存和发展问题,具有重要的现实意义.以此,结合新生代农民工人力资本问题研究的困惑,在新生代农民工人力资本特性的基础上,提出新生代农民工人力资本的3个维度和7项指标,并给出1个案例,分析新生代农民工人力资本维度的相互关系.最后,指出新生代农民工人力资本的维度分析将给新生代农民工人力资本投资问题带来诸多启示.%The use of human capital theory to study the new generation of migrant workers' living and development, has important practical significance.So, combined with the new generation of migrant workers and human capital issues of the confusion, based on the human capital characteristics of the new generation of migrant workers, the author proposed the three dimensions of human capital and seven indicators of the new generation of migrant workers, and presented a case analysis of the relationship between the human capital dimensions of the new generation of migrant workers.Finally, the author pointed out that the analysis on the new generation of migrant workers would bring some enlightenment to the capital investment of human capital of the new generation of migrant workers.

  15. Functional aspects of protein flexibility

    DEFF Research Database (Denmark)

    Teilum, Kaare; Olsen, Johan G; Kragelund, Birthe B

    2009-01-01

    Proteins are dynamic entities, and they possess an inherent flexibility that allows them to function through molecular interactions within the cell, among cells and even between organisms. Appreciation of the non-static nature of proteins is emerging, but to describe and incorporate...... this into an intuitive perception of protein function is challenging. Flexibility is of overwhelming importance for protein function, and the changes in protein structure during interactions with binding partners can be dramatic. The present review addresses protein flexibility, focusing on protein-ligand interactions....... The thermodynamics involved are reviewed, and examples of structure-function studies involving experimentally determined flexibility descriptions are presented. While much remains to be understood about protein flexibility, it is clear that it is encoded within their amino acid sequence and should be viewed...

  16. Is the Wii Fit a new-generation tool for improving balance, health and well-being? A pilot study.

    Science.gov (United States)

    Nitz, J C; Kuys, S; Isles, R; Fu, S

    2010-10-01

    The Nintendo Wii Fit is a new product that is purported to improve balance, strength, flexibility, fitness and general well-being. Currently, there are no controlled trials published to support such claims. The aim of this research was to determine the feasibility of Wii Fit in improving balance, strength, flexibility and fitness for healthy women aged between 30 and 60 years. Ten women aged 30-58 years were recruited to the study. Intervention involved a 30-min session, twice weekly for 10 weeks. The manufacturer's pre-programmed Wii Fit regime determined for age and physical ability was followed. All women were assessed before and after the 10 weeks' intervention. Demographic information collected included age, weight, and self-reported information related to habitual physical activity, regular medication, hormone replacement therapy and well-being. Balance measures included the modified Clinical Test for Sensory Integration of Balance, reaction time and unilateral stance with velocity of sway recorded. Clinical measures of balance and mobility included the Step Test, the timed Up & Go test (TUG) and the TUG(cognitive). Somatosensory testing included touch, vibration and knee-joint re-positioning ability; ankle flexibility and the muscle strengths of quadriceps, hip abductors and adductors were also measured. Cardiovascular fitness was measured using a 6-min walk test. Balance (unilateral stance, eyes open (p balance and strength that needs confirmation by statistically powered studies.

  17. [Flexible root posts].

    Science.gov (United States)

    Vadachkoriia, N R; Mandzhavidze, N A; Gumberidze, N Sh

    2009-02-01

    The article discusses the current state of restoration techniques of root canal treatment. Nowadays, technical progress allows manufacturers to develop flexible fiberglass posts, aspiring not only to an excellent aesthetics and mechanical properties (first of all, in comparison with metal and cast posts), but also to maintenance of their radio density and a wide range of forms. Growth of fiberglass posts popularity testifies to their clinical efficiency that also is confirmed by results of long-term researches. Introduction of fiberglass posts in a dental practice has rendered huge influence on restoration techniques of root canal treatment. Convincing factors of fiberglass posts superiority provide restoration the appearance similar with the natural dentition; possess close to dentine elasticity; creation of monolithic structure with hard tooth tissues and composite cement, posts, in case of need, can be easily adjusted on length, adhesive linkage of posts gives them additional stability. Modern researches have confirmed that only elastic, namely carbon fiber and the fiberglass posts made of modern technologies possess similar physical properties, as tooth structure. They can create reliable biomimetic design; solve a complex of aesthetic and functional restoration problems.

  18. Orthogonal flexible Rydberg aggregates

    Science.gov (United States)

    Leonhardt, K.; Wüster, S.; Rost, J. M.

    2016-02-01

    We study the link between atomic motion and exciton transport in flexible Rydberg aggregates, assemblies of highly excited light alkali-metal atoms, for which motion due to dipole-dipole interaction becomes relevant. In two one-dimensional atom chains crossing at a right angle adiabatic exciton transport is affected by a conical intersection of excitonic energy surfaces, which induces controllable nonadiabatic effects. A joint exciton-motion pulse that is initially governed by a single energy surface is coherently split into two modes after crossing the intersection. The modes induce strongly different atomic motion, leading to clear signatures of nonadiabatic effects in atomic density profiles. We have shown how this scenario can be exploited as an exciton switch, controlling direction and coherence properties of the joint pulse on the second of the chains [K. Leonhardt et al., Phys. Rev. Lett. 113, 223001 (2014), 10.1103/PhysRevLett.113.223001]. In this article we discuss the underlying complex dynamics in detail, characterize the switch, and derive our isotropic interaction model from a realistic anisotropic one with the addition of a magnetic bias field.

  19. Orthogonal flexible Rydberg aggregates

    CERN Document Server

    Leonhardt, K; Rost, J M

    2015-01-01

    We study the link between atomic motion and exciton transport in flexible Rydberg aggregates, assemblies of highly excited light alkali atoms, for which motion due to dipole-dipole interaction becomes relevant. In two one-dimensional atom chains crossing at a right angle adiabatic exciton transport is affected by a conical intersection of excitonic energy surfaces, which induces controllable non-adiabatic effects. A joint exciton/motion pulse that is initially governed by a single energy surface is coherently split into two modes after crossing the intersection. The modes induce strongly different atomic motion, leading to clear signatures of non-adiabatic effects in atomic density profiles. We have shown how this scenario can be exploited as an exciton switch, controlling direction and coherence properties of the joint pulse on the second of the chains [K.~Leonhardt {\\it et al.}, Phys.~Rev.~Lett. {\\bf 113} 223001 (2014)]. In this article we discuss the underlying complex dynamics in detail, characterise the ...

  20. Research on the Education of Legal Quality for New Generation of Migrant Workers%新生代农民工法律素养教育研究

    Institute of Scientific and Technical Information of China (English)

    张风超

    2015-01-01

    新生代农民工在我国现代化建设中扮演着极为重要的角色。无论从农民工自身而言还是整个社会而言,对新生代农民工进行法律素养教育都具有重要的意义。本文从新生代农民工的特点入手,分析新生代农民工法律素养教育的必要性,提出开展新生代农民工法律素养教育的策略,以期对促进我国新生代农民工法律素养教育发展有所裨益。%New generation of migrant workers play a very important role in modernization construction in our country .Having the education of legal quality is very important to both new generation of migrant workers themselves and the whole society .This paper contains the characteristics of the new generation of migrant workers ,and the necessity and strategies for developing the education of legal quality for new generation of migrant workers ,which may help the development of the education of legal quality for new generation of migrant workers .

  1. Flexible Blades for Wind Turbines

    Science.gov (United States)

    Collins, Madeline Carlisle; Macphee, David; Harris, Caleb

    2016-11-01

    Previous research has shown that windmills with flexible blades are more efficient than those with rigid blades. Flexibility offers passive pitch control, preferable to active pitch control which is costly and requires maintenance. Flexible blades morph such that the blade more closely resembles its design point at part load and over load. The lift-to-drag ratios on individual blades was investigated. A mold was designed and machined from an acrylic slab for the casting of blades with a NACA 0012 cross section. A flexible blade was cast from silicone and a rigid blade was cast from polyurethane. Each of these blades was tested in a wind tunnel, cantilever mounted, spanning the whole test section. The angle of attack was varied by rotating the mount. All tests were performed at the same wind speed. A load cell within the mount measured forces on the blade, from which the lift and drag forces were calculated. The stall point for the flexible blade occurred later than for the rigid blade, which agrees with previous research. Lift-to-drag ratios were larger for the flexible blade at all angles of attack tested. Flexible blades seem to be a viable option for passive pitch control. Future research will include different airfoil cross sections, wind speeds, and blade materials. Funding from NSF REU site Grant EEC 1358991 is greatly appreciated.

  2. 'Narwhal', a new-generation (self-propelled) semisubmersible platform for the Netherlands Offshore Co. (NOC) group

    Energy Technology Data Exchange (ETDEWEB)

    1977-10-21

    ''Narwhal'', a new-generation self-propelled semisubmersible platform for the Netherlands Offshore Co. (NOC) Group, will be delivered in 1978. It is designed as a work platform and can be used virtually at all times (88% availability), is equipped with a 2000 ton crane, measures 145 x 52 x 36 m, and has a draft of 7.50 m in transit and 23.5 m in the working position. The displacement in the working position is 94,000 tons, and it can carry a 5000 ton load distributed over its 4000 sq m area. Propulsion is effected by two electrically driven screws with 160 rpm speed and variable pitch, developing 10,000 hp to give a 9 knot cruising speed. A 250 man crew can live aboard the platform. Conventional anchoring facilities include ten electrically driven Skagit-type drum winches and ten Delta Flipper anchors weighing 15 tons each. The ballast tanks hold about 62,000 tons of liquids; the vessel also carries 900 tons of potable water and 2000 tons of diesel fuel. The main crane is an IHC/Gusto/Sumitomo Heavy Industries model 2000 H DB-B. There is also an American Hoist 9299 crane lifting 165 tons to 20 m, and various sizes of steam and hydraulic pile drivers can be provided.

  3. Development of a high-performance gantry system for a new generation of optical slope measuring profilers

    Energy Technology Data Exchange (ETDEWEB)

    Assoufid, Lahsen, E-mail: assoufid@aps.anl.gov [Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439 (United States); Brown, Nathan; Crews, Dan [ALIO Industries, 11919 I-70 Frontage Road N, Unit 119, Wheat Ridge, CO 80033 (United States); Sullivan, Joseph; Erdmann, Mark; Qian, Jun; Jemian, Pete [Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439 (United States); Yashchuk, Valeriy V. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Takacs, Peter Z. [Brookhaven National Laboratory, Upton, NY 11973 (United States); Artemiev, Nikolay A.; Merthe, Daniel J.; McKinney, Wayne R. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Siewert, Frank; Zeschke, Thomas [Helmholtz Zentrum Berlin/ BESSY-II, Institut für Nanometer Optik und Technologie, Albert-Einstein-Strasse 15 12489 Berlin (Germany)

    2013-05-11

    A new high-performance metrology gantry system has been developed within the scope of collaborative efforts of optics groups at the US Department of Energy synchrotron radiation facilities as well as the BESSY-II synchrotron at the Helmholtz Zentrum Berlin (Germany) and the participation of industrial vendors of x-ray optics and metrology instrumentation directed to create a new generation of optical slope measuring systems (OSMS) [1]. The slope measurement accuracy of the OSMS is expected to be <50 nrad, which is strongly required for the current and future metrology of x-ray optics for the next generation of light sources. The fabricated system was installed and commissioned (December 2012) at the Advanced Photon Source (APS) at Argonne National Laboratory to replace the aging APS Long Trace Profiler (APS LTP-II). Preliminary tests were conducted (in January and May 2012) using the optical system configuration of the Nanometer Optical Component Measuring Machine (NOM) developed at Helmholtz Zentrum Berlin (HZB)/BESSY-II. With a flat Si mirror that is 350 mm long and has 200 nrad rms nominal slope error over a useful length of 300 mm, the system provides a repeatability of about 53 nrad. This value corresponds to the design performance of 50 nrad rms accuracy for inspection of ultra-precise flat optics.

  4. Development of a New Generation of Flood Inundation Maps—A Case Study of the Coastal City of Tainan, Taiwan

    Directory of Open Access Journals (Sweden)

    Dong-Jiing Doong

    2016-11-01

    Full Text Available Flood risk management has become a growing priority for city managers and disaster risk prevention agencies worldwide. Correspondingly, large investments are made towards data collection, archiving and analysis and technologies such as geographic information systems (GIS and remote sensing play important role in this regard. GIS technologies offer valuable means for delineation of flood plains, zoning of areas that need protection from floods and identification of plans for development and scoping of various kinds of flood protection measures. Flood inundation maps (FIMs are particularly useful in planning flood disaster risk responses. The purpose of the present paper is to describe efforts in developing new generation of FIMs at the city scale and to demonstrate effectiveness of such maps in the case of the coastal city of Tainan, Taiwan. In the present work, besides pluvial floods, the storm surge influence is also considered. The 1D/2D coupled model SOBEK was used for flood simulations. Different indicators such as Probability of Detection (POD and Scale of Accuracy (SA were applied in the calibration and validation stages of the work and their corresponding values were found to be up to 88.1% and 68.0%, respectively. From the overall analysis, it came up that land elevation, tidal phase, and storm surge are the three dominant factors that influence flooding in Tainan. A large number of model simulations were carried out in order to produce FIMs which were then effectively applied in the stakeholder engagement process.

  5. Assessment of differences between X and gamma rays in order to validate a new generation of irradiators for insect sterilization

    Energy Technology Data Exchange (ETDEWEB)

    Mastrangelo, Thiago; Walder, Julio M.M., E-mail: piaui@cena.usp.b [Centro de Energia Nuclear na Agricultura (CENA), Piracicaba, SP (Brazil); Parker, Andrew G.; Jessup, Andrew; Orozco-Davila, Dina; Islam, Amirul; Dammalage, Thilakasiri, E-mail: A.Jessup@iaea.or [Joint FAO/IAEA-UN A-2444, Seibersdorf (Austria). Insect Pest Control Subprogramme; Pereira, Rui, E-mail: R.Cardoso-Pereira@iaea.or [Joint FAO/IAEA-UN, Vienna (Austria). Insect Pest Control Subprogramme

    2009-07-01

    Recent fears of terrorism provoked an increase in delays and denials of transboundary shipments of radioisotopes. This represents a serious constraint to sterile insect technique (SIT) programs around the world as they rely on the use of ionizing energy from radioisotopes for insect sterilization. In order to validate a novel Xray irradiator, a series of studies on Ceratitis capitata (Wiedemann) and Anastrepha fraterculus (Wiedemann) (Diptera: Tephritidae) were carried out, comparing the relative biological effectiveness (RBE) between X-rays and traditional gamma radiation from {sup 60}Co. Male C. capitata pupae and pupae of both sexes of A. fraterculus, both 24 to 48 h before adult emergence, were irradiated with doses ranging from 15 to 120 Gy and 10 to 70 Gy respectively. Estimated mean doses of 91.2 Gy of X and 124.9 Gy of gamma radiation induced 99% sterility in C. capitata males. Irradiated A. fraterculus were 99% sterile at about 40-60 Gy for both radiation treatments. Standard quality control parameters were not significantly affected by the two types of radiation. There were no significant differences between X and gamma radiation regarding mating indices. The RBE did not differ significantly between the tested X and gamma radiation, and X-rays are as biologically effective for SIT purposes as gamma rays are. This work confirms the suitability of this new generation of X-ray irradiators for pest control programs in UN Member States. (author)

  6. MACROECONOMIC DETERMINANTS OF TOTAL FACTOR PRODUCTIVITY: NEW GENERATION PANEL DATA ANALYSIS ON OECD COUNTRIES (1996-2015

    Directory of Open Access Journals (Sweden)

    ÖMER YALÇINKAYA

    2016-12-01

    Full Text Available Determining the factors which are effective on total factor productivity (TFP increments include the productivity of all factors in the production process and making improvements for these factors via policies have importance concerning speed the potential growth rate up in the long term and making this sustainable. The mediumlong term determinants of TFP are examined in this research for the 1994-2015 period as econometric within the scope of new generation panel data analysis on the OECD countries who are classified as OECD-1 and OECD-2 by their income levels. From this aspect, purposed in this research that to reveal the primary determinants which cause the differentiations between OECD-1 and OECD-2 countries in terms of their long-term economic growth performances and/or income levels. Determined as a result of the research that the effect of the variables which are used to determine the medium-long term determinants of the TFP on OECD-1 and OECD-2 groups parallelly increased and decreased as long as enhancing the representation degree of the knowledge, innovation and technological development level of the variables. These results show that the differentiation of countries in OECD-1 and OECD-2 groups in terms of long-term economic growth and/or income levels is majorly rooted in indicators which are used on behalf of knowledge, innovation, and technological development.

  7. A New Generation Microarray for the Simultaneous Detection and Identification of Yersinia pestis and Bacillus anthracis in Food

    Directory of Open Access Journals (Sweden)

    Noriko Goji

    2012-01-01

    Full Text Available The use of microarrays as a multiple analytic system has generated increased interest and provided a powerful analytical tool for the simultaneous detection of pathogens in a single experiment. A wide array of applications for this technology has been reported. A low density oligonucleotide microarray was generated from the genetic sequences of Y. pestis and B. anthracis and used to fabricate a microarray chip. The new generation chip, consisting of 2,240 spots in 4 quadrants with the capability of stripping/rehybridization, was designated as “Y-PESTIS/B-ANTHRACIS 4x2K Array.” The chip was tested for specificity using DNA from a panel of bacteria that may be potentially present in food. In all, 37 unique Y. pestis-specific and 83 B. anthracis-specific probes were identified. The microarray assay distinguished Y. pestis and B. anthracis from the other bacterial species tested and correctly identified the Y. pestis-specific oligonucleotide probes using DNA extracted from experimentally inoculated milk samples. Using a whole genome amplification method, the assay was able to detect as low as 1 ng genomic DNA as the start sample. The results suggest that oligonucleotide microarray can specifically detect and identify Y. pestis and B. anthracis and may be a potentially useful diagnostic tool for detecting and confirming the organisms in food during a bioterrorism event.

  8. SPALAX new generation: New process design for a more efficient xenon production system for the CTBT noble gas network.

    Science.gov (United States)

    Topin, Sylvain; Greau, Claire; Deliere, Ludovic; Hovesepian, Alexandre; Taffary, Thomas; Le Petit, Gilbert; Douysset, Guilhem; Moulin, Christophe

    2015-11-01

    The SPALAX (Système de Prélèvement Automatique en Ligne avec l'Analyse du Xénon) is one of the systems used in the International Monitoring System of the Comprehensive Nuclear Test Ban Treaty (CTBT) to detect radioactive xenon releases following a nuclear explosion. Approximately 10 years after the industrialization of the first system, the CEA has developed the SPALAX New Generation, SPALAX-NG, with the aim of increasing the global sensitivity and reducing the overall size of the system. A major breakthrough has been obtained by improving the sampling stage and the purification/concentration stage. The sampling stage evolution consists of increasing the sampling capacity and improving the gas treatment efficiency across new permeation membranes, leading to an increase in the xenon production capacity by a factor of 2-3. The purification/concentration stage evolution consists of using a new adsorbent Ag@ZSM-5 (or Ag-PZ2-25) with a much larger xenon retention capacity than activated charcoal, enabling a significant reduction in the overall size of this stage. The energy consumption of the system is similar to that of the current SPALAX system. The SPALAX-NG process is able to produce samples of almost 7 cm(3) of xenon every 12 h, making it the most productive xenon process among the IMS systems.

  9. On the development of the GRAPES——A new generation of the national operational NWP system in China

    Institute of Scientific and Technical Information of China (English)

    ZHANG RenHe; SHEN XueShun

    2008-01-01

    Numerical weather prediction (NWP) has become one of the most important means for weather fore-casts in the world. It also mirrors a nation's comprehensive strength in meteorology. In 2000, China Meteorological Administration (CMA) established the National Innovative Base for Meteorological Numerical Prediction in the Chinese Academy of Meteorological Sciences (CAMS), to work on devel-oping a new generation of the national operational NWP system-Global/Regional Assimilation and PrEdiction System (GRAPES), to enhance meteorological services in China in the new century. In re-cent years, the GRAPES has witnessed a fast development. The GRAPES has been set up as an inte-gration of the model framework, data assimilation, regional and global NWP system, which can be commonly used for both operation and research. In this paper, a brief review is made for illustrating the GRAPES system, including the advanced designs of the GRAPES, its diverse applications in multi-fields, and efficiencies of the regional and global GRAPES in operational applications based on hindcast results.

  10. Commissioning and early experience with a new-generation low-energy linear accelerator with advanced delivery and imaging functionalities

    Directory of Open Access Journals (Sweden)

    Fogliata Antonella

    2011-09-01

    Full Text Available Abstract Background A new-generation low-energy linear accelerator (UNIQUE was introduced in the clinical arena during 2009 by Varian Medical Systems. The world's first UNIQUE was installed at Oncology Institute of Southern Switzerland and put into clinical operation in June 2010. The aim of the present contribution was to report experience about its commissioning and first year results from clinical operation. Methods Commissioning data, beam characteristics and the modeling into the treatment planning system were summarized. Imaging system of UNIQUE included a 2D-2D matching capability and tests were performed to identify system repositioning capability. Finally, since the system is capable of delivering volumetric modulated arc therapy with RapidArc, a summary of the tests performed for such modality to assess its performance in preclinical settings and during clinical usage was included. Results Isocenter virtual diameter was measured as less than 0.2 mm. Observed accuracy of isocenter determination and repositioning for 2D-2D matching procedures in image guidance was Conclusions The results of the commissioning tests and of the first period of clinical operation, resulted meeting specifications and having good margins respect to tolerances. UNIQUE was put into operation for all delivery techniques; in particular, as shown by the pre-treatment quality assurance results, it enabled accurate and safe delivery of RapidArc plans.

  11. 迎接新一代通信网来临%Prospects of New Generation Communication Network

    Institute of Scientific and Technical Information of China (English)

    张煦

    2001-01-01

    参照国际上报道关于数据通信业务量和移动手机数量发展的预测,认为在运营竞争、市场扩大和技术引进三方面的推动下,现行通信网必将进化为新一代通信网。较详细地描述新一代以数据为重心、分组为基本的核心网轮廓并描绘了第三代无线蜂窝网和移动卫星系统的前景。%The paper takes as reference the two international predictions for the rapid developments of data communication traffic and mobile handsets during the early years of the new century. Under the influence of three major driving forces business environment,service/market,and technolgy advance, the evolution to a new-generation communication network would be forthcoming very soon. The paper attempts in detail to describe the outlook of data-centric,packet-based core network for national fixed telecommunicat ions,as well as the third-generation wireless cellular network and satellite systems for globalmobile communication.

  12. VIENTOS: a feasibility study of innovative pupil systems for the new generation of instruments in the large telescopes

    Science.gov (United States)

    García-Vargas, M. L.; Pérez-Calpena, A.; Gallego, J.; Gil de Paz, A.; Sánchez-Blanco, E.; Martínez-Delgado, I.; Maldonado Medina, M.; Zamorano Calvo, J.

    2012-09-01

    The goal of VIENTOS project is to analyze pupil innovative systems that could be used in the new generation of instruments for the large telescopes. This study tries to identify the current scientific needs, to understand why some of them have not been fulfilled yet (due to pre-conceived technical ideas or to managerial reasons) and to propose optomechanical solutions for these pupil elements that could produce a qualitative leap in the performance of the instruments to operate in the large telescopes. VIENTOS is currently on-going as a collaborative project between FRACTAL and the University Complutense of Madrid (UCM) and is being partially funded by a CDTI grant under the program Industry for Science. CDTI is the Development and Industrial Transfer Center from the Minister of Science and Innovation (Spain). Among the different innovative systems that we have carried out, our team has explored potential solutions for narrow band Imaging with tunable filters in the near-IR and a novel pupil system called sliced-pupil grating, a device designed for increasing the spectral resolution in astronomical spectrographs, without changing the geometry of the main optics. Nanotechnology customized filters to be applicable to astronomical systems are under study.

  13. Histological Ex Vivo Evaluation of Peri-Incisional Thermal Effect Created by a New-Generation CO2 Superpulsed Laser

    Directory of Open Access Journals (Sweden)

    G. Palaia

    2014-01-01

    Full Text Available The purpose of this study is the evaluation of the histological effects of a new-generation superpulsed CO2 laser through an “ex vivo” study. A CO2 (λ = 10,600 nm ultra-speed laser (SmartUS20D, DEKA, Florence, Italy has been used at different parameters from 2 to 4 watt in Continuous Wave (CW and Pulsed Wave (PW, 50 Hz to obtain 30 samples from pig cadaver tongues. All the specimens have been subdivided into 6 groups (from A to F and each group consisted of 5 samples. A final specimen has been taken by scalpel and used as control group. Histological analysis has been performed using an optical microscope (Leica DM 2000 at a magnification of ×40. Results showed that histological readability was optimal in all the samples. The thermal damage has been negligible in all the groups. Furthermore, the average of thermal damage was 0,095 mm in the epithelial, while it was 0.245 mm in the connective tissue. Statistical analysis using Graphpad Prism 5 software showed no significant differences among the groups. CO2 laser demonstrated a good surgical effectiveness provoking little peripheral damage onto the cut edges and allowing a safe histological diagnosis.

  14. Multiple Lipid Nanoparticles (MLN), a New Generation of Lipid Nanoparticles for Drug Delivery Systems: Lamivudine-MLN Experimental Design.

    Science.gov (United States)

    Cavalcanti, Suellen M T; Nunes, Cláudia; Lima, Sofia A C; Soares-Sobrinho, José L; Reis, Salette

    2017-06-01

    An optimized methodology for the development of a new generation of lipid nanoparticles, the multiple lipid nanoparticles (MLN) is described. MLN have characteristics between nanostructured lipid carriers (NLC) and multiple emulsions (W/O/W), but without the outer aqueous phase. The production is based on a hot homogenization method combined with high shear and ultrasonication. The antiretroviral agent lamivudine (3TC), was loaded in the MLN. For comparison purposes, NLC-3TC formulation was also developed and physico-chemically characterized by the same parameters as MLN-3TC. The development and optimization of MLN and NLC formulations were supported by a Quality by Design (QbD) approach. The MLN-3TC formulation exhibited a size of about 450 nm, polydispersity -20 mV. Furthermore, the morphology assessed by TEM showed a structure with multiples aqueous vacuoles. MLN-3TC was physically stable for at least 45 days, had low cytotoxicity and drug release studies showed a sustained and controlled release of 3TC under gastric and plasma-simulated conditions (at pH 7.4 for about 45 h). The optimized formulations present suitable profiles for oral administration. Overall, the results reveal that MLN present higher loading capacity and storage stability than NLC.

  15. A new generation of 99.999% enriched 28Si single crystals for the determination of Avogadro’s constant

    Science.gov (United States)

    Abrosimov, N. V.; Aref'ev, D. G.; Becker, P.; Bettin, H.; Bulanov, A. D.; Churbanov, M. F.; Filimonov, S. V.; Gavva, V. A.; Godisov, O. N.; Gusev, A. V.; Kotereva, T. V.; Nietzold, D.; Peters, M.; Potapov, A. M.; Pohl, H.-J.; Pramann, A.; Riemann, H.; Scheel, P.-T.; Stosch, R.; Wundrack, S.; Zakel, S.

    2017-08-01

    A metrological challenge is currently underway to replace the present definition of the kilogram. One prerequisite for this is that the Avogadro constant, N A, which defines the number of atoms in a mole, needs to be determined with a relative uncertainty of better than 2  ×  10-8. The method applied in this case is based on the x-ray crystal density experiment using silicon crystals. The first attempt, in which silicon of natural isotopic composition was used, failed. The solution chosen subsequently was the usage of silicon highly enriched in 28Si from Russia. First, this paper reviews previous efforts from the very first beginnings to an international collaboration with the goal of producing a 28Si single crystal with a mass of 5 kg, an enrichment greater than 0.9999 and of sufficient chemical purity. Then the paper describes the activities of a follow-up project, conducted by PTB, to produce a new generation of highly enriched silicon in order to demonstrate the quasi-industrial and reliable production of more than 12 kg of the 28Si material with enrichments of five nines. The intention of this project is also to show the availability of 28Si single crystals as a guarantee for the future realisation of the redefined kilogram.

  16. Feeding practices and nutritional status of Mexican children affiliated to the Medical Insurance for a New Generation.

    Science.gov (United States)

    Flores-Huerta, Samuel; Klünder-Klünder, Miguel; Muñoz-Hernández, Onofre

    2012-01-01

    To identify feeding practices and nutritional status in children affiliated to the Medical Insurance for a New Generation (SMNG). An in-home survey addressed to mothers which included anthropometric measures of children; performed in March and April 2009 in Mexican States. The prevalence of any form of breastfeeding was (months) 6-11: 67.9%; 12-17: 43.6%; 18-23: 26.4%; >23: 16.7%; with higher figures in rural children. BF duration was eight months. Continued breastfeeding at 1 year of age was 43%. At 1 year of age, almost all children consumed fruits, vegetables, cereals and legumes; however, 13.5%-20.3% did not consume foods of animal origin, but ~84% and ~60% consumed fried and sweet foods and soft drinks. Nutrisano (a food supplement) was consumed by just 2/3 of the Oportunidades Children. Stunting and overweight were the predominant alterations of nutritional status. Improving the nutritional status of children affiliated to the SMNG requires promotion of appropriate healthy dietary practices and the surveillance of infant growth.

  17. Multi-omic profiles of hepatic metabolism in TPN-fed preterm pigs administered new generation lipid emulsions.

    Science.gov (United States)

    Guthrie, Gregory; Kulkarni, Madhulika; Vlaardingerbroek, Hester; Stoll, Barbara; Ng, Kenneth; Martin, Camilia; Belmont, John; Hadsell, Darryl; Heird, William; Newgard, Christopher B; Olutoye, Oluyinka; van Goudoever, Johannes; Lauridsen, Charlotte; He, Xingxuan; Schuchman, Edward H; Burrin, Douglas

    2016-09-01

    We aimed to characterize the lipidomic, metabolomic, and transcriptomic profiles in preterm piglets administered enteral (ENT) formula or three parenteral lipid emulsions [parenteral nutrition (PN)], Intralipid (IL), Omegaven (OV), or SMOFlipid (SL), for 14 days. Piglets in all parenteral lipid groups showed differential organ growth versus ENT piglets; whole body growth rate was lowest in IL piglets, yet there were no differences in either energy expenditure or (13)C-palmitate oxidation. Plasma homeostatic model assessment of insulin resistance demonstrated insulin resistance in IL, but not OV or SL, compared with ENT. The fatty acid and acyl-CoA content of the liver, muscle, brain, and plasma fatty acids reflected the composition of the dietary lipids administered. Free carnitine and acylcarnitine (ACT) levels were markedly reduced in the PN groups compared with ENT piglets. Genes associated with oxidative stress and inflammation were increased, whereas those associated with alternative pathways of fatty acid oxidation were decreased in all PN groups. Our results show that new generation lipid emulsions directly enrich tissue fatty acids, especially in the brain, and lead to improved growth and insulin sensitivity compared with a soybean lipid emulsion. In all total PN groups, carnitine levels are limiting to the formation of ACTs and gene expression reflects the stress of excess lipid on liver function.

  18. Swarming: flexible roaming plans.

    Science.gov (United States)

    Partridge, Jonathan D; Harshey, Rasika M

    2013-03-01

    Movement over an agar surface via swarming motility is subject to formidable challenges not encountered during swimming. Bacteria display a great deal of flexibility in coping with these challenges, which include attracting water to the surface, overcoming frictional forces, and reducing surface tension. Bacteria that swarm on "hard" agar surfaces (robust swarmers) display a hyperflagellated and hyperelongated morphology. Bacteria requiring a "softer" agar surface (temperate swarmers) do not exhibit such a dramatic morphology. For polarly flagellated robust swarmers, there is good evidence that restriction of flagellar rotation somehow signals the induction of a large number of lateral flagella, but this scenario is apparently not relevant to temperate swarmers. Swarming bacteria can be further subdivided by their requirement for multiple stators (Mot proteins) or a stator-associated protein (FliL), secretion of essential polysaccharides, cell density-dependent gene regulation including surfactant synthesis, a functional chemotaxis signaling pathway, appropriate cyclic (c)-di-GMP levels, induction of virulence determinants, and various nutritional requirements such as iron limitation or nitrate availability. Swarming strategies are as diverse as the bacteria that utilize them. The strength of these numerous designs stems from the vantage point they offer for understanding mechanisms for effective colonization of surface niches, acquisition of pathogenic potential, and identification of environmental signals that regulate swarming. The signature swirling and streaming motion within a swarm is an interesting phenomenon in and of itself, an emergent behavior with properties similar to flocking behavior in diverse systems, including birds and fish, providing a convenient new avenue for modeling such behavior.

  19. Flexible armored blanket development

    Energy Technology Data Exchange (ETDEWEB)

    Roth, E.S.

    1978-05-01

    An exploratory development contract was undertaken on December 23, 1977 which had as its purpose the development and demonstration of a flexible armored blanket design suitable for providing ballistic protection to nuclear weapons during shipment. Objectives were to design and fabricate a prototype blanket which will conform to the weapon shape, is troop-handleable in the field, and which, singly or in multiple layers, can defeat a range of kinetic energy armor piercing (AP) ammunition potentially capable of damaging the critical portion of the nuclear weapon. Following empirical testing, including the firing of threat ammunition under controlled laboratory and field test conditions, materials were selected and assembled into two blanket designs, each weighing approximately 54 kg/m{sup 2} (11 lbs/ft{sup 2}) and estimated to cost from $111 to $180 per ft{sup 2} in production. A firing demonstration to evidence blanket performance against terrorist/light infantry weapons, heavy infantry weapons, and aircraft cannon was conducted for representatives of the DOD and interested Sandia employees on April 12, 1978. The blankets performed better than anticipated defeating bullets up to 7.62 mm x 51 mm AP with one layer and projectiles up to 23 mm HEI with two layers. Based on these preliminary tests it is recommended that development work be continued with the following objectives: (1) the selection by the DOD of priority applications, (2) the specific design and fabrication of sufficient quantities of armored blankets for field testing, (3) the evaluation of the blankets by DOD operational units, with reports to Sandia Laboratories to enable final design.

  20. Guideline Implementation: Processing Flexible Endoscopes.

    Science.gov (United States)

    Bashaw, Marie A

    2016-09-01

    The updated AORN "Guideline for processing flexible endoscopes" provides guidance to perioperative, endoscopy, and sterile processing personnel for processing all types of reusable flexible endoscopes and accessories in all procedural settings. This article focuses on key points of the guideline to help perioperative personnel safely and effectively process flexible endoscopes to prevent infection transmission. The key points address verification of manual cleaning, mechanical cleaning and processing, storage in a drying cabinet, determination of maximum storage time before reprocessing is needed, and considerations for implementing a microbiologic surveillance program. Perioperative RNs should review the complete guideline for additional information and for guidance when writing and updating policies and procedures.

  1. Flexible Learning in a Digital World.

    Science.gov (United States)

    Collis, Betty; Moonen, Jef

    2002-01-01

    Defines flexible learning and describes components of flexible learning in higher education, including technology, pedagogy or instructional approach, implementation strategies, and institutional framework. Considers factors constraining learning flexibility; changing student characteristics; and the need for lifelong learning, particularly in the…

  2. A positive mood, a flexible brain

    OpenAIRE

    Betzel, Richard F.; Satterthwaite, Theodore D.; Gold, Joshua I.; Bassett, Danielle S.

    2016-01-01

    Flexible reconfiguration of human brain networks supports cognitive flexibility and learning. However, modulating flexibility to enhance learning requires an understanding of the relationship between flexibility and brain state. In an unprecedented longitudinal data set, we investigate the relationship between flexibility and mood, demonstrating that flexibility is positively correlated with emotional state. Our results inform the modulation of brain state to enhance response to training in h...

  3. 浅析新生代农民工融入城市问题%Problems of Urban Integration of the New Generation Migrant-workers

    Institute of Scientific and Technical Information of China (English)

    索喜娜; 杨香合; 刘亭

    2012-01-01

    This article analyzed the obstacles of urban integration of the new generation migrant workers from both the internal factors and external factors.It also pointed out that self promotion and external help could promote the new generation migrant laborers to merge with urban.%从内部因素与外界因素2个方面对新生代农民工融入城市障碍进行了分析,指出自身提升与外部帮助多管齐下是促进新生代农民工融入城市的有效措施。

  4. Important innovations in conventional drivage technology by a new generation of drilling jumbos; Massgebende Innovationen in der konventionellen Vortriebstechnologie durch eine neue Bohrwagengeneration

    Energy Technology Data Exchange (ETDEWEB)

    Wennmohs, Karl-Heinz [Atlas Copco MCT GmbH, Essen (Germany). Global Strategic Customers

    2009-01-29

    Important innovations in the development of the new generation of drilling jumbos led to an increase in the performance of conventional drivage technology, which had previously not been considered possible. An important factor in addition to the high drilling rate is the greater precision of the kinematics. This permits important cost savings on concrete and re-profiling. At the same time customer requirements such as the pre-drilling technology, recording of drilling parameters, profile monitoring and communication engineering were implemented in this new generation of drilling jumbos. (orig.)

  5. Aggregating and Disaggregating Flexibility Objects

    DEFF Research Database (Denmark)

    Siksnys, Laurynas; Valsomatzis, Emmanouil; Hose, Katja

    2015-01-01

    In many scientific and commercial domains we encounter flexibility objects, i.e., objects with explicit flexibilities in a time and an amount dimension (e.g., energy or product amount). Applications of flexibility objects require novel and efficient techniques capable of handling large amounts...... energy data management and discuss strategies for aggregation and disaggregation of flex-objects while retaining flexibility. This paper further extends these approaches beyond flex-objects originating from energy consumption by additionally considering flex-objects originating from energy production...... and aiming at energy balancing during aggregation. In more detail, this paper considers the complete life cycle of flex-objects: aggregation, disaggregation, associated requirements, efficient incremental computation, and balance aggregation techniques. Extensive experiments based on real-world data from...

  6. Two-dimensional flexible nanoelectronics

    National Research Council Canada - National Science Library

    Akinwande, Deji; Petrone, Nicholas; Hone, James

    2014-01-01

    .... With the discovery of hexagonal boron nitride as an ideal dielectric, the materials are now in place to advance integrated flexible nanoelectronics, which uniquely take advantage of the unmatched...

  7. Flexible Transparent Electronic Gas Sensors.

    Science.gov (United States)

    Wang, Ting; Guo, Yunlong; Wan, Pengbo; Zhang, Han; Chen, Xiaodong; Sun, Xiaoming

    2016-07-01

    Flexible and transparent electronic gas sensors capable of real-time, sensitive, and selective analysis at room-temperature, have gained immense popularity in recent years for their potential to be integrated into various smart wearable electronics and display devices. Here, recent advances in flexible transparent sensors constructed from semiconducting oxides, carbon materials, conducting polymers, and their nanocomposites are presented. The sensing material selection, sensor device construction, and sensing mechanism of flexible transparent sensors are discussed in detail. The critical challenges and future development associated with flexible and transparent electronic gas sensors are presented. Smart wearable gas sensors are believed to have great potential in environmental monitoring and noninvasive health monitoring based on disease biomarkers in exhaled gas.

  8. Flexible sensors based on nanoparticles.

    Science.gov (United States)

    Segev-Bar, Meital; Haick, Hossam

    2013-10-22

    Flexible sensors can be envisioned as promising components for smart sensing applications, including consumer electronics, robotics, prosthetics, health care, safety equipment, environmental monitoring, homeland security and space flight. The current review presents a concise, although admittedly nonexhaustive, didactic review of some of the main concepts and approaches related to the use of nanoparticles (NPs) in flexible sensors. The review attempts to pull together different views and terminologies used in the NP-based sensors, mainly those established via electrical transduction approaches, including, but, not confined to: (i) strain-gauges, (ii) flexible multiparametric sensors, and (iii) sensors that are unaffected by mechanical deformation. For each category, the review presents and discusses the common fabrication approaches and state-of-the-art results. The advantages, weak points, and possible routes for future research, highlighting the challenges for NP-based flexible sensors, are presented and discussed as well.

  9. Flexible protection for metal bellows

    Science.gov (United States)

    Kimble, K. G.

    1970-01-01

    RTV silicone is used with a braided wire sheath surrounding the metal bellows in fluid transfer systems. It demonstrated best overall performance in flexibility and shock absorbing tests, high temperature, low temperature, and salt spray.

  10. 经脐单孔联合硬膜外穿刺针输尿管镜下疝囊高位结扎术治疗儿童腹股沟斜疝%Trans-umbilical single-port ureteroscopic assisted high ligation of inguinal hernia sac with epidural puncture needle in treatment of indirect inguinal hernia in children

    Institute of Scientific and Technical Information of China (English)

    刘立成; 张艳华; 董蕤; 韩艳波; 陈俊慧; 高建; 张海涛; 马文民

    2015-01-01

    目的:评价经脐单孔联合硬膜外穿刺针输尿管镜下疝囊高位结扎术治疗儿童腹股沟斜疝的安全性与确切性。方法回顾性分析2012年5月至2013年12月,河北省滦县人民医院应用经脐单孔联合硬膜外穿刺针输尿管镜下疝囊高位结扎术治疗儿童腹股沟斜疝126例的临床资料。结果本组患者手术过程均顺利,手术时间5~18 min,切口无需缝合。术后1~2 d 出院。随访10~17个月,无复发。结论经脐单孔联合硬膜外穿刺针输尿管镜下疝囊高位结扎术治疗儿童腹股沟斜疝,在缝合过程中疝囊可获得输尿管镜钳的夹持固定,疝囊高位结扎确切,硬膜外穿刺针穿刺缝合过程中无需刺破腹膜,精确疝囊结扎,可同时发现及处理对侧隐性腹股沟疝,值得临床推广。%Objective To evaluate the safety and feasibility of trans-umbilical ureteroscopic assisted high ligation of hernia sac with epidural puncture needle in treatment of indirect inguinal hernia in children. Methods During May 2012 and December 2013,126 children who underwent trans-umbilical single-port ureteroscopic high ligation of hernia sac with an epidural puncture needle in Luanxian People's Hospital,were retrospectively analyzed in this study.Results All operations were successful completed.It took 5 to 18 minutes for the operations.No suture was needed for incision closure.Postoperative hospital stay was1 to 2 days.During the follow-up of 10 to 17 months,there was no no recurrence.Conclusions With trans-umbilical ureteroscopic high ligation of hernia sac combined with epidural puncture needle,hernia sac can be clamped and fixed by ureteroscopic forceps when suturing;and hernia sac high ligation can exactly performed without peritoneum puncturing,when the epidural puncture needle is used to suture;also,it is easy to find and deal with contralateral occult hernia during operation.It is worth the clinical promotion.

  11. Ureteroscopic pneumatic lithotripsy in the treatment of upper urinary tract obstruction by ureteral cal-culi during pregnancy%输管尿镜下气压弹道碎石术治疗妊娠期输尿管结石引起上尿路梗阻

    Institute of Scientific and Technical Information of China (English)

    郑卓敏; 庄泽平; 连乐林; 黄芸珊; 陈燕东

    2016-01-01

    Objective To evaluate the feasibility and clinical efficacy of ureteroscopic pneumatic lithotrips in the treatment of upper urinary tract obstruction by ureteral calculi in pregnant women.Methods Thirty six women diagnosed with upper urinary tract obstruction by ureteral calculi during pregnancy were char-acterized with persistent and recurrent severe renal colic.Ureteroscope-guided pneumatic lithotripsy was per-formed.Results The ureteral calculi were successfully treated in 32 patients by ureteroscopic pneumatic litho-trips.Double-J ureteral stents were retained in four patients complicated with pyonephrosis,who were treated with extracorporeal shock wave lithotripsy after parturition.Renal colic and fever were absent after surgery.No abortion,prematurity,fetal death,ureter perforation or avulsion was noted.All pregnant women had full-term delivery and all newborns were healthy.Conclusion Ureteroscopic pneumatic lithotripsy could effectively and safely alleviate renal colic and treat obstruction in pregnant women with upper urinary tract obstruction by ure-teral calculi.%目的:探讨利用输尿管镜气压弹道碎石术治疗妊娠期输尿管结石引起上尿路梗阻的可行性及临床效果。方法对36例持续性或反复发作剧烈肾绞痛的妊娠期输尿管结石引起上尿路梗阻患者,采用输尿管镜下气压弹道碎石术治疗,观察手术疗效及安全性。结果输尿管镜下气压弹道碎石术一次性碎石成功32例,4例输尿管上段结石患者因合并脓肾予留置双 J 管,待患者妊娠结束后行体外冲击波碎石。术后所有患者的肾绞痛、发热等症状消失。36例均未出现流产、早产或死胎,无出现输尿管穿孔、撕脱等并发症,所有孕妇均足月分娩,新生儿发育均正常。结论输尿管镜下气压弹道碎石术治疗妊娠期输尿管结石引起上尿路梗阻能有效缓解患者疼痛,解除梗阻,且安全性高。

  12. FLEXIBLE FLATFOOT IN CHILDREN (REVIEW)

    OpenAIRE

    Владимир Маркович Кенис; Юрий Алексеевич Лапкин; Руслан Халилович Хусаинов; Андрей Викторович Сапоговский

    2014-01-01

    Flatfoot is one of the most common musculoskeletal conditions in the daily practice of pediatric orthopedists. Despite of numerous studies, diagnostic criteria and principles of management remain controversial. Flexible flatfoot - is visually detectable decrease in the height of the longitudinal arch of the foot, which can be spontaneously corrected by active or passive motion and not accompanied by any contracture of foot and ankle. Flexible flatfoot is a benign condition which is normal for...

  13. Value of Flexibility - Phase 1

    Science.gov (United States)

    2010-09-25

    flexibility could also change the calculus of how we determine when to start a new program vice modifying an existing one. Flexibility could even help...decades ago by Steward as a ‖framework for formally identifying and tracking relationships between design variables‖ [ Steward , 1981]. Keese [2007...Paper presented at the 6th Conference on Systems Engineering Research, Los Angeles, CA. Shreve, S. E. (2004). Stochastic calculus for finance. New

  14. Flexible packaging for PV modules

    Science.gov (United States)

    Dhere, Neelkanth G.

    2008-08-01

    Economic, flexible packages that provide needed level of protection to organic and some other PV cells over >25-years have not yet been developed. However, flexible packaging is essential in niche large-scale applications. Typical configuration used in flexible photovoltaic (PV) module packaging is transparent frontsheet/encapsulant/PV cells/flexible substrate. Besides flexibility of various components, the solder bonds should also be flexible and resistant to fatigue due to cyclic loading. Flexible front sheets should provide optical transparency, mechanical protection, scratch resistance, dielectric isolation, water resistance, UV stability and adhesion to encapsulant. Examples are Tefzel, Tedlar and Silicone. Dirt can get embedded in soft layers such as silicone and obscure light. Water vapor transmittance rate (WVTR) of polymer films used in the food packaging industry as moisture barriers are ~0.05 g/(m2.day) under ambient conditions. In comparison, light emitting diodes employ packaging components that have WVTR of ~10-6 g/(m2.day). WVTR of polymer sheets can be improved by coating them with dense inorganic/organic multilayers. Ethylene vinyl acetate, an amorphous copolymer used predominantly by the PV industry has very high O2 and H2O diffusivity. Quaternary carbon chains (such as acetate) in a polymer lead to cleavage and loss of adhesional strength at relatively low exposures. Reactivity of PV module components increases in presence of O2 and H2O. Adhesional strength degrades due to the breakdown of structure of polymer by reactive, free radicals formed by high-energy radiation. Free radical formation in polymers is reduced when the aromatic rings are attached at regular intervals. This paper will review flexible packaging for PV modules.

  15. Flexible solar-array mechanism

    Science.gov (United States)

    Olson, M. C.

    1972-01-01

    One of the key elements of the flexible rolled-up solar array system is a mechanism to deploy, retract, and store the flexible solar-cell arrays. The selection of components, the design of the mechanism assembly, and the tests that were performed are discussed. During 6 months in orbit, all mission objectives were satisfied, and inflight performance has shown good correlation with preflight analyses and tests.

  16. Flexible Learning Spaces Evaluation Report

    OpenAIRE

    Bullimore, A.; Reader, K.; Sultany, A

    2013-01-01

    City University, London is tackling the challenge of ensuring the learning spaces provided are able to meet the anticipated increase in technology usage and prevalent pedagogies. There is no longer a standard classroom design that will achieve this goal and therefore it is imperative to pilot and explore a variety of flexible learning spaces. This report feeds back on an\\ud evaluation of two flexible learning space approaches piloted in the autumn term of 2012 as alternatives to traditional c...

  17. Truck Rollover Characterization for Class-8 Tractor-Trailers Utilizing Standard Dual Tires and New-Generation Single Tires

    Energy Technology Data Exchange (ETDEWEB)

    Capps, Gary [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). National Transportation Research Center; Knee, Bill [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). National Transportation Research Center; Franzese, Oscar [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). National Transportation Research Center; Pollock, Paul [Dana Corporation, Kalamazoo, MI (United States). Commercial Vehicle Systems Division; Coleman, Daniel [Dana Corporation, Kalamazoo, MI (United States). Commercial Vehicle Systems Division; Janajreh, Ibrahim [Michelin Americas Research and Development Corporation, Greenville, SC (United States); Haas, Steven [Michelin Americas Research and Development Corporation, Greenville, SC (United States); Frey, Norm [Michelin Americas Research and Development Corporation, Greenville, SC (United States); Law, Harry [Clemson Univ., SC (United States). Fluor Daniel Engineering Innovation Building; Johnson, Eric [Clemson Univ., SC (United States). Fluor Daniel Engineering Innovation Building; Lawson, Robert [Clemson Univ., SC (United States). Fluor Daniel Engineering Innovation Building; Petrolino, Joe [National Transportation Research Center, Inc., Knoxville, TN (United States); Rice, Dave [National Transportation Research Center, Inc., Knoxville, TN (United States)

    2005-07-30

    The Heavy Truck Rollover Characterization Project is a major research effort conducted by the National Transportation Research Center, Inc. (NTRCI) in partnership with Oak Ridge National Laboratory (ORNL), Dana Corporation (Dana), Michelin Americas Research and Development Corporation (Michelin) and Clemson University (Clemson), under the NTRCIs Heavy Vehicle Safety Research Center (HVSRC) for the Federal Highway Administration (FHWA). ORNL provided the day-to-day management of the project. The expertise mix of this team coupled with complementary research needs and interests, and a positive can-do attitude provided an extremely positive experimental research opportunity for all involved. Furthermore, this team supplied significant and valuable resources that provided a strong positive benchmark regarding the ability to conduct research within a public-private partnership. The work conducted by this team focused on initial efforts to generate data and information on heavy truck rollover not currently available in the industry. It reflects efforts within Phases 1 and 2 of a longer-term four-phase research program. A 1999 Peterbilt 379 class-8 tractor and 2004 Wabash dry freight van trailer were the test vehicles utilized in this effort. Both were instrumented with a number of sensors to capture the dynamics of the tractor and trailer as it engaged in various testing maneuvers that included: an evasive maneuver, swept sine, constant radius, and a run-off-the-road maneuver. The run-off-the-road maneuver was discontinued because the test track could not safety accommodate such a maneuver. These maneuvers were carried out utilizing both standard dual tires and new-generation dual tires in six test series. Two test series also included the use of a wider-slider suspension. Outriggers were placed on the test vehicle to assure that an actual rollover would not occur, however, the tests were designed to generate lift-off of tires during the tests. One of the main objectives

  18. Developmental constraints on behavioural flexibility.

    Science.gov (United States)

    Holekamp, Kay E; Swanson, Eli M; Van Meter, Page E

    2013-05-19

    We suggest that variation in mammalian behavioural flexibility not accounted for by current socioecological models may be explained in part by developmental constraints. From our own work, we provide examples of constraints affecting variation in behavioural flexibility, not only among individuals, but also among species and higher taxonomic units. We first implicate organizational maternal effects of androgens in shaping individual differences in aggressive behaviour emitted by female spotted hyaenas throughout the lifespan. We then compare carnivores and primates with respect to their locomotor and craniofacial adaptations. We inquire whether antagonistic selection pressures on the skull might impose differential functional constraints on evolvability of skulls and brains in these two orders, thus ultimately affecting behavioural flexibility in each group. We suggest that, even when carnivores and primates would theoretically benefit from the same adaptations with respect to behavioural flexibility, carnivores may nevertheless exhibit less behavioural flexibility than primates because of constraints imposed by past adaptations in the morphology of the limbs and skull. Phylogenetic analysis consistent with this idea suggests greater evolutionary lability in relative brain size within families of primates than carnivores. Thus, consideration of developmental constraints may help elucidate variation in mammalian behavioural flexibility.

  19. Oxide Heteroepitaxy for Flexible Optoelectronics.

    Science.gov (United States)

    Bitla, Yugandhar; Chen, Ching; Lee, Hsien-Chang; Do, Thi Hien; Ma, Chun-Hao; Qui, Le Van; Huang, Chun-Wei; Wu, Wen-Wei; Chang, Li; Chiu, Po-Wen; Chu, Ying-Hao

    2016-11-30

    The emerging technological demands for flexible and transparent electronic devices have compelled researchers to look beyond the current silicon-based electronics. However, fabrication of devices on conventional flexible substrates with superior performance are constrained by the trade-off between processing temperature and device performance. Here, we propose an alternative strategy to circumvent this issue via the heteroepitaxial growth of transparent conducting oxides (TCO) on the flexible mica substrate with performance comparable to that of their rigid counterparts. With the examples of ITO and AZO as a case study, a strong emphasis is laid upon the growth of flexible yet epitaxial TCO relying muscovite's superior properties compared to those of conventional flexible substrates and its compatibility with the present fabrication methods. Besides excellent optoelectro-mechanical properties, an additional functionality of high-temperature stability, normally lacking in the current state-of-the-art transparent flexitronics, is provided by these heterostructures. These epitaxial TCO electrodes with good chemical and thermal stabilities as well as mechanical durability can significantly contribute to the field of flexible, light-weight, and portable smart electronics.

  20. Transarterial Chemoembolization for Hepatocellular Carcinoma with a New Generation of Beads: Clinical–Radiological Outcomes and Safety Profile

    Energy Technology Data Exchange (ETDEWEB)

    Spreafico, Carlo, E-mail: carlo.spreafico@istitutotumori.mi.it; Cascella, Tommaso, E-mail: tommaso.cascella@istitutotumori.mi.it [Fondazione Istituto Tumori, Department of Radiology (Italy); Facciorusso, Antonio, E-mail: antonio.facciorusso@istitutotumori.mi.it; Sposito, Carlo, E-mail: carlo.sposito@istitutotumori.mi.it [Fondazione Istituto Tumori, Department of Liver Surgery and Transplant (Italy); Rodolfo, Lanocita, E-mail: rodolfo.lanocita@istitutotumori.mi.it; Morosi, Carlo, E-mail: carlo.morosi@istitutotumori.mi.it; Civelli, Enrico M., E-mail: enrico.civelli@istitutotumori.mi.it; Vaiani, Marta, E-mail: marta.vaiani@istitutotumori.mi.it [Fondazione Istituto Tumori, Department of Radiology (Italy); Bhoori, Sherrie, E-mail: sherrie.bhoori@istitutotumori.mi.it [Fondazione Istituto Tumori, Department of Liver Surgery and Transplant (Italy); Pellegrinelli, Alessandro, E-mail: alessandro.pellegrinelli@istitutotumori.mi.it [Fondazione Istituto Tumori, Department of Pathology (Italy); Marchianò, Alfonso, E-mail: alfonso.marchiano@istitutotumori.mi.it [Fondazione Istituto Tumori, Department of Radiology (Italy); Mazzaferro, Vincenzo, E-mail: vincenzo.mazzaferro@istitutotumori.mi.it [Fondazione Istituto Tumori, Department of Liver Surgery and Transplant (Italy)

    2015-02-15

    PurposeTo evaluate the short-term safety and efficacy of the new generation of 70–150 µm drug-eluting beads (M1 DEB) in patients with hepatocellular carcinoma undergoing transarterial chemoembolization (TACE) as a primary therapy or as a bridge to liver transplantation (LT).MethodsForty-five consecutive patients underwent TACE with M1 DEB loaded with doxorubicin (DEBDOX/M1). Clinical data were recorded at 12, 24, and 48 h, 7 and 30 days after treatment. Response was assessed by computed tomographic scan according to the modified response evaluation criteria in solid tumors criteria, and a second DEBDOX/M1 TACE was scheduled within 6 weeks in case of a noncomplete response.ResultsAll patients had well-compensated cirrhosis (97.7 % Child A, 44.4 % hepatitis C virus, median age 61 years). Twenty patients (44.4 %) had Barcelona Clinic for Liver Cancer class B disease; the median number of nodules and their sum of diameters were 2 (range 1–6) and 43 mm (range 10–190), respectively. The mean number of TACE procedures per patient was 1.4. Objective response rate (complete + partial response) was 77.7 % with a median time to best response of 3 months (95 % confidence interval 2–4). In 13 patients, DEBDOX/M1 TACE served as a bridge/downstaging to LT/surgery. Pathology showed that more than 90 % necrosis was achieved in 10 of 28 nodules. DEBDOX/M1 TACE was well tolerated, and the grade 3/4 adverse event rate was low (1 of 65 procedures).ConclusionDEBDOX/M1 TACE is an effective procedure with a favorable safety profile and promising results in terms of objective response rate, tumor downstaging, and necrosis.

  1. The Human Pancreas as a Source of Protolerogenic Extracellular Matrix Scaffold for a New-generation Bioartificial Endocrine Pancreas.

    Science.gov (United States)

    Peloso, Andrea; Urbani, Luca; Cravedi, Paolo; Katari, Ravi; Maghsoudlou, Panagiotis; Fallas, Mario Enrique Alvarez; Sordi, Valeria; Citro, Antonio; Purroy, Carolina; Niu, Guoguang; McQuilling, John P; Sittadjody, Sivanandane; Farney, Alan C; Iskandar, Samy S; Zambon, Joao P; Rogers, Jeffrey; Stratta, Robert J; Opara, Emmanuel C; Piemonti, Lorenzo; Furdui, Cristina M; Soker, Shay; De Coppi, Paolo; Orlando, Giuseppe

    2016-07-01

    Our study aims at producing acellular extracellular matrix scaffolds from the human pancreas (hpaECMs) as a first critical step toward the production of a new-generation, fully human-derived bioartificial endocrine pancreas. In this bioartificial endocrine pancreas, the hardware will be represented by hpaECMs, whereas the software will consist in the cellular compartment generated from patient's own cells. Extracellular matrix (ECM)-based scaffolds obtained through the decellularization of native organs have become the favored platform in the field of complex organ bioengineering. However, the paradigm is now switching from the porcine to the human model. To achieve our goal, human pancreata were decellularized with Triton-based solution and thoroughly characterized. Primary endpoints were complete cell and DNA clearance, preservation of ECM components, growth factors and stiffness, ability to induce angiogenesis, conservation of the framework of the innate vasculature, and immunogenicity. Secondary endpoint was hpaECMs' ability to sustain growth and function of human islet and human primary pancreatic endothelial cells. Results show that hpaECMs can be successfully and consistently produced from human pancreata and maintain their innate molecular and spatial framework and stiffness, and vital growth factors. Importantly, hpaECMs inhibit human naïve CD4 T-cell expansion in response to polyclonal stimuli by inducing their apoptosis and promoting their conversion into regulatory T cells. hpaECMs are cytocompatible and supportive of representative pancreatic cell types. We, therefore, conclude that hpaECMs has the potential to become an ideal platform for investigations aiming at the manufacturing of a regenerative medicine-inspired bioartificial endocrine pancreas.

  2. Investigations of perspective technologies, equipment and sanitary - hygienic means for Life-Support System of new generation

    Science.gov (United States)

    Shumilina, I. V.

    Creation of optimal sanitary - hygienic conditions allows to keep health and capacity of the crewmembers work at increase of space flight duration. There is a wide application experience of means, methods and equipment for sanitary - hygienic supply, which were developed and experimentally tested for space flights. However, about 800 kg personal hygiene means (napkins and towels are made with water and delivered with the Earth) are necessary for 3 crewmembers per one year. For long orbital and interplanetary flights (without an opportunity of stocks updating) it is necessary to increase a degree of Life-Support System isolation and optimization of goods turnover. Washing combined with water regeneration system is most perspective for sanitary - hygienic procedures. Therefore, creation of space equipment for washing with sanitary - hygienic water (SHW) regeneration system is especially important. The researches have shown, that to processes, which can be applied for SHW regeneration in space conditions and require insignificant quantity of additional materials (as against sorption), concern membrane methods (reverse osmosis, nanofiltration etc.). Two-step membrane unit for SHW regeneration recovered no less than 85 % of permeate with the organic and inorganic selectivity of 82-95 %. The tests of two-step membrane unit for SHW regeneration carried out on mock up solutions and real SHW, containing detergents really used in space flight conditions. The researches on a substantiation of an opportunity of clothing washing, clothing drying and the estimation of an opportunity of application of various detergents for clothing washing are urgent. The tests of water extraction technology from textile materials are carried out. Is established, that at conditional time of contact 1s, humidity of a leaving air flow from clothing drying unit comes nearer to 100 %. It is necessary to solve the problem for creation of Life-Support System of new generation for long-term space

  3. Study on the Performance and Commercial Application of New Generation DMMC-1 Type Catalyst for Deep Catalytic Cracking

    Institute of Scientific and Technical Information of China (English)

    Long Jun; Tian Huiping; Liu Yujian; Xie Chaogang; Li Jibing

    2007-01-01

    Over the past decades SINOPEC has been uninterruptedly engaging in the development and upgrading of deep catalytic cracking(DCC)technology for manufacturing propylene from heavy oil.Recently SINOPEC after having made a lot of progress in the area of oil refining at the molecular level has developed a new generation DMMC-1 type catalyst designed for the DCC process.The laboratory evaluation tests have shown that compared to the existing MMC-2 type catalyst that features the best comprehensive performance,the DMMC-1 type catalyst has increased the propylene yield by 2.2% with the propylene selectivity increased by 10%.The saidcatalyst has improved its ability for heavy oil cracking and coke selectivity along with reduction of olefin content in gasoline to achieve a better product distribution and improve the product quality.The resuIts of application of the said catalyst in a 650-kt/a commercial DCC unit at SINOPEC Anqing Branch Company have revealed that the DMMC-1 catalyst demonstrated an enhanced capabilitv for heavy oil cracking and could increase the total liquid yield to 84.56 m%from 83.92 m%,the LPG vield to 38.90 m% from 34.60 m%,the propylene yield to 17.80 m% from 15.37 m% and the propylene concentration to 45.91 m% from 44.91 m%,and reduce the coke yield from 7.61 m% to 7.05 m% and the olefin content in gasoline from 42.3v% to 37.5 v%,resulting in an incremental profit amounting to 52.19 million RMB a year.This technology has further upgradedand developed the DCC technology which has been commanding a leading position among the industry peers.

  4. Extreme genetic heterogeneity among the nine major tribal Taiwanese island populations detected with a new generation Y23 STR system.

    Science.gov (United States)

    Zeng, Zhaoshu; Garcia-Bertrand, Ralph; Calderon, Silvia; Li, Li; Zhong, Mingxia; Herrera, Rene J

    2014-09-01

    The Taiwanese aborigines have been regarded as the source populations for the Austronesian expansion that populated Oceania to the east and Madagascar off Africa to the West. Although a number of genetic studies have been performed on some of these important tribes, the scope of the investigations has been limited, varying in the specific populations examined as well as the maker systems employed. This has made direct comparison among studies difficult. In an attempt to alleviate this lacuna, we investigate, for the first time, the genetic diversity of all nine major Taiwanese aboriginal tribes (Ami, Atayal, Bunun, Rukai, Paiwan, Saisat, Puyuma, Tsou and Yami) utilizing a new generation multiplex Y-STR system that allows for the genotyping of 23 loci from a single amplification reaction. This comprehensive approach examining 293 individuals from all nine main tribes with the same battery of forensic markers provides for the much-needed equivalent data essential for comparative analyses. Our results have uncovered that these nine major aboriginal populations exhibit limited intrapopulation genetic diversity and are highly heterogeneous from each other, possibly the result of endogamy, isolation, drift and/or unique ancestral populations. Specifically, genetic diversity, discrimination capacity, fraction of unique haplotypes and the most frequent haplotypes differ among the nine tribes, with the Tsou possessing the lowest values for the first three of these parameters. The phylogenetic analyses performed indicate that the genetic diversity among all nine tribes is greater than the diversity observed among the worldwide reference populations examined, indicating an extreme case of genetic heterogeneity among these tribes that have lived as close neighbors for thousands of years confined to the limited geographical area of an island.

  5. New generation NMR bioreactor coupled with high-resolution NMR spectroscopy leads to novel discoveries in Moorella thermoacetica metabolic profiles.

    Science.gov (United States)

    Xue, Junfeng; Isern, Nancy G; Ewing, R James; Liyu, Andrei V; Sears, Jesse A; Knapp, Harlan; Iversen, Jens; Sisk, Daniel R; Ahring, Birgitte K; Majors, Paul D

    2014-10-01

    An in situ nuclear magnetic resonance (NMR) bioreactor was developed and employed to monitor microbial metabolism under batch growth conditions in real time. We selected Moorella thermoacetica ATCC 49707 as a test case. M. thermoacetica (formerly Clostridium thermoaceticum) is a strictly anaerobic, thermophilic, acetogenic, gram-positive bacterium with potential for industrial production of chemicals. The metabolic profiles of M. thermoacetica were characterized during growth in batch mode on xylose (a component of lignocellulosic biomass) using the new generation NMR bioreactor in combination with high-resolution NMR (HR-NMR) spectroscopy. In situ NMR measurements were performed using water-suppressed H-1 NMR spectroscopy at 500 MHz, and aliquots of the bioreactor contents were taken for 600-MHz HR-NMR spectroscopy at specific intervals to confirm metabolite identifications and expand metabolite coverage. M. thermoacetica demonstrated the metabolic potential to produce formate, ethanol, and methanol from xylose, in addition to its known capability of producing acetic acid. Real-time monitoring of bioreactor conditions showed a temporary pH decrease, with a concomitant increase in formic acid during exponential growth. Fermentation experiments performed outside of the magnet showed that the strong magnetic field employed for NMR detection did not significantly affect cell metabolism. Use of the in situ NMR bioreactor facilitated monitoring of the fermentation process, enabling identification of intermediate and endpoint metabolites and their correlation with pH and biomass produced during culture growth. Real-time monitoring of culture metabolism using the NMR bioreactor in combination with HR-NMR spectroscopy will allow optimization of the metabolism of microorganisms producing valuable bioproducts.

  6. Monte carlo method for the uncertainty evaluation of spatial straightness error based on new generation geometrical product specification

    Science.gov (United States)

    Wen, Xiulan; Xu, Youxiong; Li, Hongsheng; Wang, Fenglin; Sheng, Danghong

    2012-09-01

    Straightness error is an important parameter in measuring high-precision shafts. New generation geometrical product specification(GPS) requires the measurement uncertainty characterizing the reliability of the results should be given together when the measurement result is given. Nowadays most researches on straightness focus on error calculation and only several research projects evaluate the measurement uncertainty based on "The Guide to the Expression of Uncertainty in Measurement(GUM)". In order to compute spatial straightness error(SSE) accurately and rapidly and overcome the limitations of GUM, a quasi particle swarm optimization(QPSO) is proposed to solve the minimum zone SSE and Monte Carlo Method(MCM) is developed to estimate the measurement uncertainty. The mathematical model of minimum zone SSE is formulated. In QPSO quasi-random sequences are applied to the generation of the initial position and velocity of particles and their velocities are modified by the constriction factor approach. The flow of measurement uncertainty evaluation based on MCM is proposed, where the heart is repeatedly sampling from the probability density function(PDF) for every input quantity and evaluating the model in each case. The minimum zone SSE of a shaft measured on a Coordinate Measuring Machine(CMM) is calculated by QPSO and the measurement uncertainty is evaluated by MCM on the basis of analyzing the uncertainty contributors. The results show that the uncertainty directly influences the product judgment result. Therefore it is scientific and reasonable to consider the influence of the uncertainty in judging whether the parts are accepted or rejected, especially for those located in the uncertainty zone. The proposed method is especially suitable when the PDF of the measurand cannot adequately be approximated by a Gaussian distribution or a scaled and shifted t-distribution and the measurement model is non-linear.

  7. New generation NMR bioreactor coupled with high-resolution NMR spectroscopy leads to novel discoveries in Moorella thermoaceticum metabolic profiles

    Energy Technology Data Exchange (ETDEWEB)

    Xue, Junfeng; Isern, Nancy G.; Ewing, R James; Liyu, Andrey V.; Sears, Jesse A.; Knapp, Harlan; Iversen, Jens; Sisk, Daniel R.; Ahring, Birgitte K.; Majors, Paul D.

    2014-06-20

    An in-situ nuclear magnetic resonance (NMR) bioreactor was developed and employed to monitor microbial metabolism under batch-growth conditions in real time. We selected Moorella thermoacetica ATCC 49707 as a test case. M. thermoacetica (formerly Clostridium thermoaceticum) is a strictly anaerobic, thermophilic, acetogenic, gram-positive bacterium with potential for industrial production of chemicals. The metabolic profiles of M. thermoacetica were characterized during growth in batch mode on xylose (a component of lignocellulosic biomass) using the new generation NMR bioreactor in combination with high-resolution, high sensitivity NMR (HR-NMR) spectroscopy. In-situ NMR measurements were performed using water-suppressed H-1 NMR spectroscopy at an NMR frequency of 500 MHz, and aliquots of the bioreactor contents were taken for 600 MHz HR-NMR spectroscopy at specific intervals to confirm metabolite identifications and expand metabolite coverage. M. thermoacetica demonstrated the metabolic potential to produce formate, ethanol and methanol from xylose, in addition to its known capability of producing acetic acid. Real-time monitoring of bioreactor conditions showed a temporary pH decrease, with a concomitant increase in formic acid during exponential growth. Fermentation experiments performed outside of the magnet showed that the strong magnetic field employed for NMR detection did not significantly affect cell metabolism. Use of the in-situ NMR bioreactor facilitated monitoring of the fermentation process in real time, enabling identification of intermediate and end-point metabolites and their correlation with pH and biomass produced during culture growth. Real-time monitoring of culture metabolism using the NMR bioreactor in combination with the HR-NMR spectroscopy will allow optimization of the metabolism of microorganisms producing valuable bioproducts.

  8. Clinical evaluation of emboli removal by integrated versus non-integrated arterial filters in new generation oxygenators.

    Science.gov (United States)

    Jabur, Ghazwan Ns; Sidhu, Karishma; Willcox, Timothy W; Mitchell, Simon J

    2016-07-01

    To compare the emboli filtration efficiency of five integrated or non-integrated oxygenator-filter combinations in cardiopulmonary bypass circuits. Fifty-one adult patients underwent surgery using a circuit with an integrated filtration oxygenator or non-integrated oxygenator with a separate 20 µm arterial line filter (Sorin Dideco Avant D903 + Pall AL20 (n=12), Sorin Inspire 6 M + Pall AL20 (n=10), Sorin Inspire 6M F (n=9), Terumo FX25 (n=10), Medtronic Fusion (n=10)). The Emboli Detection and Classification quantifier was used to count emboli upstream and downstream of the primary filter throughout cardiopulmonary bypass. The primary outcome measure was to compare the devices in respect of the median proportion of emboli removed. One device (Sorin Inspire 6 M + Pall AL20) exhibited a significantly greater median percentage reduction (96.77%, IQR=95.48 - 98.45) in total emboli counts compared to all other devices tested (p=0.0062 - 0.0002). In comparisons between the other units, they all removed a greater percentage of emboli than one device (Medtronic Fusion), but there were no other significant differences. The new generation Sorin Inspire 6 M, with a stand-alone 20 µm arterial filter, appeared most efficient at removing incoming emboli from the circuit. No firm conclusions can be drawn about the relative efficacy of emboli removal by units categorised by class (integrated vs non-integrated); however, the stand-alone 20 µm arterial filter presently sets a contemporary standard against which other configurations of equipment can be judged. © The Author(s) 2015.

  9. Physico-chemical properties of the new generation IV iron preparations ferumoxytol, iron isomaltoside 1000 and ferric carboxymaltose.

    Science.gov (United States)

    Neiser, Susann; Rentsch, Daniel; Dippon, Urs; Kappler, Andreas; Weidler, Peter G; Göttlicher, Jörg; Steininger, Ralph; Wilhelm, Maria; Braitsch, Michaela; Funk, Felix; Philipp, Erik; Burckhardt, Susanna

    2015-08-01

    The advantage of the new generation IV iron preparations ferric carboxymaltose (FCM), ferumoxytol (FMX), and iron isomaltoside 1000 (IIM) is that they can be administered in relatively high doses in a short period of time. We investigated the physico-chemical properties of these preparations and compared them with those of the older preparations iron sucrose (IS), sodium ferric gluconate (SFG), and low molecular weight iron dextran (LMWID). Mössbauer spectroscopy, X-ray diffraction, and Fe K-edge X-ray absorption near edge structure spectroscopy indicated akaganeite structures (β-FeOOH) for the cores of FCM, IIM and IS, and a maghemite (γ-Fe2O3) structure for that of FMX. Nuclear magnetic resonance studies confirmed the structure of the carbohydrate of FMX as a reduced, carboxymethylated, low molecular weight dextran, and that of IIM as a reduced Dextran 1000. Polarography yielded significantly different fingerprints of the investigated compounds. Reductive degradation kinetics of FMX was faster than that of FCM and IIM, which is in contrast to the high stability of FMX towards acid degradation. The labile iron content, i.e. the amount of iron that is only weakly bound in the polynuclear iron core, was assessed by a qualitative test that confirmed decreasing labile iron contents in the order SFG ≈ IS > LMWID ≥ FMX ≈ IIM ≈ FCM. The presented data are a step forward in the characterization of these non-biological complex drugs, which is a prerequisite to understand their cellular uptake mechanisms and the relationship between the structure and physiological safety as well as efficacy of these complexes.

  10. A new generation of trade policy: potential risks to diet-related health from the trans pacific partnership agreement.

    Science.gov (United States)

    Friel, Sharon; Gleeson, Deborah; Thow, Anne-Marie; Labonte, Ronald; Stuckler, David; Kay, Adrian; Snowdon, Wendy

    2013-10-16

    Trade poses risks and opportunities to public health nutrition. This paper discusses the potential food-related public health risks of a radical new kind of trade agreement: the Trans Pacific Partnership agreement (TPP). Under negotiation since 2010, the TPP involves Australia, Brunei, Canada, Chile, Japan, Malaysia, Mexico, New Zealand, Peru, Singapore, the USA, and Vietnam. Here, we review the international evidence on the relationships between trade agreements and diet-related health and, where available, documents and leaked text from the TPP negotiations. Similar to other recent bilateral or regional trade agreements, we find that the TPP would propose tariffs reductions, foreign investment liberalisation and intellectual property protection that extend beyond provisions in the multilateral World Trade Organization agreements. The TPP is also likely to include strong investor protections, introducing major changes to domestic regulatory regimes to enable greater industry involvement in policy making and new avenues for appeal. Transnational food corporations would be able to sue governments if they try to introduce health policies that food companies claim violate their privileges in the TPP; even the potential threat of litigation could greatly curb governments' ability to protect public health. Hence, we find that the TPP, emblematic of a new generation of 21st century trade policy, could potentially yield greater risks to health than prior trade agreements. Because the text of the TPP is secret until the countries involved commit to the agreement, it is essential for public health concerns to be articulated during the negotiation process. Unless the potential health consequences of each part of the text are fully examined and taken into account, and binding language is incorporated in the TPP to safeguard regulatory policy space for health, the TPP could be detrimental to public health nutrition. Health advocates and health-related policymakers must be

  11. Investigation and Analysis of Vocational Education for Chinese Migrant Workers of New Generation--Reflection from a Special Investigation in F City

    Science.gov (United States)

    Zhuoxin, Liang

    2013-01-01

    The research has chosen some migrant workers of new generation from different fields in F City to investigate their current situation of vocational education. The research reveals that their education is helpful, mainly in employment, work and the methods of mentorship and further study organized by employers. The research also reveals its…

  12. Stent fracture and longitudinal compression detected on coronary CT angiography in the first- and new-generation drug-eluting stents.

    Science.gov (United States)

    Chung, Mi Sun; Yang, Dong Hyun; Kim, Young-Hak; Roh, Jae-Hyung; Song, Jihyun; Kang, Joon-Won; Ahn, Jung-Min; Park, Duk-Woo; Kang, Soo-Jin; Lee, Seung-Whan; Lee, Cheol Whan; Park, Seong-Wook; Park, Seung-Jung; Lim, Tae-Hwan

    2016-04-01

    To evaluated prevalence and clinical implication of stent fracture and longitudinal compression in first- and new-generation drug-eluting stents (DES) using coronary computed tomography angiography (CCTA). The incidence of stent fracture and longitudinal compression were compared between first- and new-generation DES in 374 patients who underwent coronary stenting using DES and follow-up CCTA due to recurrent angina. 235 and 139 patients received 322 first- and 213 new-generation DES, respectively. The crude per-stent incidence of longitudinal compression (6.1 vs. 0.3 %, p stent fracture (11.3 vs. 8.1 %, p = 0.23) was comparable. On follow-up coronary angiography for 347 stents, stent fracture (3.2 %) and longitudinal compression (0.9 %) were less detected than those on CCTA. Ostial stenting was a risk factor of longitudinal compression (p Stent fracture was associated with younger patients (p = 0.03), longer stent (p = 0.010), and excessively tortuous lesions (p = 0.001). The presence of stent fracture or longitudinal compression was not associated with poor clinical outcomes. The longitudinal compression more frequently occurred after new-generation DES implantation. The stent fracture was comparable between two DES. However, the occurrence of such mechanical deformities did not translate into a poor clinical outcome.

  13. Reflections on Happiness Management of the New Generation Employees of the Enterprises%企业新生代员工幸福管理的思考

    Institute of Scientific and Technical Information of China (English)

    葛元月

    2014-01-01

    New generation employees refers to the generation after 80s and 90s. The professional survey data of recruitment shows that nearly 30%workers who were born after 80s has served as director or higher position, the new generation employees become the backbone for the development of enterprise, and the stability of the group is the stability of the development of enterprise. Based on the general analysis of the characteristics of the new generation employees, this paper analyzes the problems profoundly in the happiness management of the new generation employees. Combined with the reality, suggestions about how to strengthen happiness management of new generation employees are put forward.%新生代员工泛指80-90后员工群体。智联招聘的职场调查数据显示,近三成80后出生的职场人已经担任主管以上管理岗位,新生代员工渐成企业发展的生力军,稳定了这个群体,就是稳定了企业的发展。本文在系统分析新生代员工职场特质的基础上,深刻剖析新生代员工目前幸福管理中出现的问题,并结合实际,就如何加强新生代员工幸福管理提出了一些建议。

  14. Analysis of essential oils and fragrances with a new generation of highly inert gas chromatographic columns coated with ionic liquids.

    Science.gov (United States)

    Cagliero, Cecilia; Bicchi, Carlo; Cordero, Chiara; Liberto, Erica; Rubiolo, Patrizia; Sgorbini, Barbara

    2017-04-28

    In the fields of essential oils and fragrances, samples often consist of mixtures of compounds with similar structural and physical characteristics (e.g. mono- and sesquiterpenoids), whose correct identification closely depends on the synergic combination of chromatographic and mass spectral data. This sample complexity means that new GC stationary phases with different selectivities are continually being investigated. Ionic liquids (ILs) are of great interest as GC stationary phases in this field because of their selectivity (significantly different than that of currently phases) and their high temperature stability. A first generation of IL GC columns was found to be competitive when applied to these field, in terms of selectivity and efficiency, compared to conventional columns (polydimethylsiloxane, (e.g. OV-1), methyl-polysiloxane 5%-phenyl (e.g. SE-52), 7%-cyanopropyl, 7%-phenyl polysiloxane (e.g. OV-1701), and polyethylen glycol (e.g. PEG-20M). However, these columns showed significant activity towards polar or active analytes, which primarily affected their quantitative performance. A new generation of highly-inactive columns coated with three of the most widely-used ionic liquid GC stationary phases has recently been introduced; these phases are SLB-IL60i (1,12-di(tripropylphosphonium) dodecane bis(trifluoromethylsulfonyl) imide [NTf2], SLB-IL76i (tri-(tripropylphosphonium-hexanamido)-triethylamine [NTf2]), and SLB-IL111i (1,5-di (2,3-dimethyllimidazolium) pentane [NTf2]). This study carefully tested the new inert IL columns, in view of their routine application in the fragrance and essential oil fields. They were found to have unusually high selectivity, comparable to that of first-generation IL columns, while their inertness and efficiency were competitive with those of currently-used conventional columns. The IL column performance of first and second generations was compared, through the quali-quantitative analysis of components in a group of different

  15. A new generation of CMOS-compatible high frequency micro-inductors with ferromagnetic cores: Theory, fabrication and characterisation

    Energy Technology Data Exchange (ETDEWEB)

    Seemann, K. [Forschungszentrum Karlsruhe in der Helmholtz-Gemeinschaft, Institut fuer Materialforschung I, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany)]. E-mail: klaus.seemann@imf.fzk.de; Leiste, H. [Forschungszentrum Karlsruhe in der Helmholtz-Gemeinschaft, Institut fuer Materialforschung I, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Bekker, V. [Forschungszentrum Karlsruhe in der Helmholtz-Gemeinschaft, Institut fuer Materialforschung I, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany)

    2006-07-15

    A new generation of CMOS-compatible micro-inductor prototypes with magnetic cores were realized, characterised as well as theoretically modelled in a frequency range up to 4 GHz, a frequency range where, e.g., mobile communication and global positioning systems (GPS) are operated. The micro-inductor's electrical magnitudes like inductance (L) and quality factor (Q) were theoretically described by means of an equivalent circuit model taking the frequency behaviour of the magnetic film core, expressed by the Landau-Lifschitz and Maxwell equations, into account. Six inch targets were used to deposit metallic layers (Al{sub 99}Si{sub 0.5}Cu{sub 0.5}), diffusion barriers (Si{sub 3}N{sub 4}), insulating layers (SiO{sub 2}) and magnetic films (Fe{sub 39}Co{sub 3}Ta{sub 8}N{sub 23}) by DC or reactive r.-f.-magnetron sputtering. All film materials were patterned by NUV-lithography (Near Ultra Violet), plasma beam milling and reactive ion etching to form the micro-inductors on 4-inch silicon wafers. The inductor windings are arranged in a way that they possess a low resistance and generate a quasi closed flux at the end of the cores to minimise eddy current losses in the silicon substrate. In order to diminish demagnetising effects in an efficient working core the magnetic films were patterned into micro squares with lateral dimensions of 20 and 100 {mu}m with 100 nm in thickness. More magnetic volume and a higher micro-inductor cross-section was achieved by producing 100 nm magnetic double layers separated by a 800 nm thick Si{sub 3}N{sub 4} inter-layer. To guarantee a sufficiently high cut-off frequency of the magnetic films, they were annealed in a static magnetic field at a temperature of 400 deg. C for uniaxial anisotropy induction. This represents a temperature treatment where aluminium CMOS processes take place. As a result of patterning, the magnetic film material exhibited a remarkable increase of the cut-off frequency from 2 GHz in laterally extended films up

  16. FLEXIBLE BUDGET OF SPORT COMPETITIONS

    Directory of Open Access Journals (Sweden)

    Dragan Vukasović

    2009-11-01

    Full Text Available Manager of sport competition has right to decide and also to take responsibility for costs, income and financial results. From economic point of wiev flexible budget and planning cost calculations is top management base for analyzing success level of sport competition. Flexible budget is made before sport competition with few output level, where one is always from static plan-master plan. At the end of competition when we have results, we make report of plan executing and we also analyzing plan variances. Results of comparation between achieved and planning level of static budget can be acceptable if achieved level is approximate to budget level or if we analyzing results from gross or net income. Flexible budget become very important in case of world eco- nomic crises

  17. Inorganic semiconductors for flexible electronics.

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Y.; Rogers, J. A.; Center for Nanoscale Materials; Univ. of Illinois

    2007-08-03

    This article reviews several classes of inorganic semiconductor materials that can be used to form high-performance thin-film transistors (TFTs) for large area, flexible electronics. Examples ranging from thin films of various forms of silicon to nanoparticles and nanowires of compound semiconductors are presented, with an emphasis on methods of depositing and integrating thin films of these materials into devices. Performance characteristics, including both electrical and mechanical behavior, for isolated transistors as well as circuits with various levels of complexity are reviewed. Collectively, the results suggest that flexible or printable inorganic materials may be attractive for a range of applications not only in flexible but also in large-area electronics, from existing devices such as flat-panel displays to more challenging (in terms of both cost and performance requirements) systems such as large area radiofrequency communication devices, structural health monitors, and conformal X-ray imagers.

  18. Global Flexibility, synecdoche of progress

    Directory of Open Access Journals (Sweden)

    Clara Selva Olid

    2014-06-01

    Full Text Available The purpose of this article is to explore the flexibility, its uses, types and new concepts to address and empower the global flexibility as an integral tool to facilitate change, adapt to the environment in an advantageous manner and innovate. In times of economic, social, technological and global chances, like today, partners and organizations are claimed to increase their polyvalence and versatility, in order to move towards new organizational and dedication models. In this context and given the need to have a construct that broadly and inherently meets and baste transversely to the different stakeholders of the organization, its structures and forms and mediation between them emerges global flexibility. Despite the challenge of proposing and permeabilising a new construct, no less what it provides, as it is presented as a natural tool to empower wellbeing within organizational and social life.

  19. Wearable Flexible Sensors: A Review

    KAUST Repository

    Nag, Anindya

    2017-05-18

    The paper provides a review on some of the significant research work done on wearable flexible sensors (WFS). Sensors fabricated with flexible materials have been attached to a person along with the embedded system to monitor a parameter and transfer the significant data to the monitoring unit for further analyses. The use of wearable sensors has played a quite important role to monitor physiological parameters of a person to minimize any malfunctioning happening in the body. The paper categorizes the work according to the materials used for designing the system, the network protocols and different types of activities that were being monitored. The challenges faced by the current sensing systems and future opportunities for the wearable flexible sensors regarding its market values are also briefly explained in the paper.

  20. Studies Of Residual Flexibility And Vibration Testing

    Science.gov (United States)

    Admire, John R.; Tinker, Michael L.; Bookout, Paul S.; Ivey, Edward W.

    1995-01-01

    Collection of reports presents theoretical and experimental studies in which concept of residual flexibility applied to modal vibration testing and verification of mathematical models of vibrations of flexible structure constrained by another structure. "Residual flexibility" denotes that part of interface flexibility due to mode shapes out of frequency range of test. Studies directed toward assessing residual-flexibility approach as substitute for fixed-base vibrational testing of payloads installed in spacecraft.

  1. Polymer electronics a flexible technology

    CERN Document Server

    Technology, Rapra

    2009-01-01

    The worldwide market for polymer electronic products has been estimated to be worth up to £15 billion by 2015 and the opportunity for new markets could be as high as £125 billion by 2025.'The rapid development of polymer electronics has revealed the possibility for transforming the electronics market by offering lighter, flexible and more cost effective alternatives to conventional materials and products. With applications ranging from printed, flexible conductors and novel semiconductor components to intelligent labels and large area displays and solar panels, products that were previously un

  2. Lost and Found in Flexibility

    DEFF Research Database (Denmark)

    Bødker, Susanne; Christiansen, Ellen

    2002-01-01

    'New work' is characterized by mobility and flexibility and a growing need to facilitate social awareness. The paper discusses how to augment the environment with social awareness and suggest 'awareness-in-transition' as a lable for awareness in mobile work in flexible work environments......, and as locus for building social awareness in the 'new work'. A transition (e.g. taking information from a whiteboard in a meeting room to the desktop of a personal computer)--besides the immediate implications at the functional level--has important interpersonal, intra-personal, and organizational...

  3. Flexible Stamp for Nanoimprint Lithography

    DEFF Research Database (Denmark)

    Nielsen, Theodor; Pedersen, Rasmus H.; Hansen, Ole

    2005-01-01

    The design, fabrication and performance of a flexible silicon stamp for homogenous large area nanoimprint lithography (NIL) are presented. The flexible stamp is fabricated by bulk semiconductor micro machining of a 4-inch silicon wafer and consists of thick anchor like imprint areas connected...... by membranes. The bending stiffness difference between the imprint areas and the membranes ensures that the deformation of the stamp during the imprint process mainly takes place in the membranes, leaving the imprint structures unaffected. By this design the strong demand to the parallelism between stamp...

  4. Balancing energy flexibilities through aggregation

    DEFF Research Database (Denmark)

    Valsomatzis, Emmanouil; Hose, Katja; Pedersen, Torben Bach

    2014-01-01

    One of the main goals of recent developments in the Smart Grid area is to increase the use of renewable energy sources. These sources are characterized by energy fluctuations that might lead to energy imbalances and congestions in the electricity grid. Exploiting inherent flexibilities, which exist...... in both energy production and consumption, is the key to solving these problems. Flexibilities can be expressed as flex-offers, which due to their high number need to be aggregated to reduce the complexity of energy scheduling. In this paper, we discuss balance aggregation techniques that already during...

  5. Global Analysis of Flexible Risers

    DEFF Research Database (Denmark)

    Banke, Lars

    1996-01-01

    and thus resists the loading from the environment in a more suitable way.A flexible pipe is a composite structure, built up of several layers each having a specific function. Due to the flexibility, the response of the pipe in wave induced motions are governed by a complex hydroelastic set of differential...... parameters.The idea is to divide the riser system of riser and end fitting system into a global system including the riser and a local system of the bending stiffener and the end fitting. The forces at top of the riser shall be used as input for the design of the local system.This report introduces a non...

  6. 新生代农民工心理健康问题研究%Study on the Mental Health Problems of New Generation of Migrant Workers

    Institute of Scientific and Technical Information of China (English)

    罗贻琳; 龚岱辰

    2015-01-01

    随着社会的发展,新生代农民工逐步成为农民工群体的中坚力量,新生代农民工群体的心理健康状况是农民工问题重要的一部分,新生代农民工心理健康问题日渐引起社会各界的关注与重视。与传统的农民工相比,新生代农民工普遍缺少从事农业生产劳动的经历,他们具有时代性、发展性、双重性、边缘性等特点,解决新生代农民工心理健康问题需要通过政府、社会、企业和新生代农民工自身的共同努力,只有这样才能促进社会的健康、稳定与和谐,促进社会的良性运行与协调发展。%With the development of society , the new generation of migrant workers gradually become the backbone of migrant workers, and mental health of the new generation of migrant workers is an important part of the migrant workers , and the mental health problems of the new generation of migrant workers gradually get the concerns of the communities and their attention .Compared with the traditional migrant workers , the new generation of migrant workers are generally lack of experience of engaging in agricultur -al production and labor , but they are featured with keeping pace with the times , the development of resistance , dualities , marginal-ness.The new generation of migrant workers to solve the problems of mental health needs the efforts of the government , the commu-nity, the industries and the new generation of migrant workers of their own efforts .It’ s the only way to promote the healthy , stable and harmonious society , promote the healthy operation and coordination of the development of society .

  7. Assessment of urban pluvial flood risk and efficiency of adaptation options through simulations - A new generation of urban planning tools

    Science.gov (United States)

    Löwe, Roland; Urich, Christian; Sto. Domingo, Nina; Mark, Ole; Deletic, Ana; Arnbjerg-Nielsen, Karsten

    2017-07-01

    We present a new framework for flexible testing of flood risk adaptation strategies in a variety of urban development and climate scenarios. This framework couples the 1D-2D hydrodynamic simulation package MIKE FLOOD with the agent-based urban development model DAnCE4Water and provides the possibility to systematically test various flood risk adaptation measures ranging from large infrastructure changes over decentralised water management to urban planning policies. We have tested the framework in a case study in Melbourne, Australia considering 9 scenarios for urban development and climate and 32 potential combinations of flood adaptation measures. We found that the performance of adaptation measures strongly depended on the considered climate and urban development scenario and the other implementation measures implemented, suggesting that adaptive strategies are preferable over one-off investments. Urban planning policies proved to be an efficient means for the reduction of flood risk, while implementing property buyback and pipe increases in a guideline-oriented manner was too costly. Random variations in location and time point of urban development could have significant impact on flood risk and would in some cases outweigh the benefits of less efficient adaptation strategies. The results of our setup can serve as an input for robust decision making frameworks and thus support the identification of flood risk adaptation measures that are economically efficient and robust to variations of climate and urban layout.

  8. Robotic steering of flexible endoscopes

    NARCIS (Netherlands)

    Rozeboom, Esther

    2016-01-01

    Flexible endoscopes were originally designed for non-invasive inspection of body cavities and hollow organs. Today, they are also used for complex minimal invasive interventions. Control of the endoscope is difficult and complexity rises with interventional procedures. Endoscopists suffer from long

  9. Flexible Bistable Cholesteric Reflective Displays

    Science.gov (United States)

    Yang, Deng-Ke

    2006-03-01

    Cholesteric liquid crystals (ChLCs) exhibit two stable states at zero field condition-the reflecting planar state and the nonreflecting focal conic state. ChLCs are an excellent candidate for inexpensive and rugged electronic books and papers. This paper will review the display cell structure,materials and drive schemes for flexible bistable cholesteric (Ch) reflective displays.

  10. Lifelong Open and Flexible Learning

    DEFF Research Database (Denmark)

    Bang, Jørgen

    2006-01-01

    and Flexible (LOF) learning embracing characteristics as: open learning, distance learning, e-learning, online learning, open accessibility, multimedia support, virtual mobility, learning communities, dual mode (earn & learn) approaches, and the like.In my presentation I will focus on the EADTU strategies...

  11. Flexible Learning: A Luddite View

    Science.gov (United States)

    Baggaley, Jon

    2011-01-01

    This article reflects on the flexible learning concept through the eyes of the 19th-century industrial activists known as the Luddites. During a period of economic uncertainty, the Luddite perspective provides a sensitive justification for a change-free educational environment, and for a backlash in favour of "inflexible learning" (IL). The…

  12. Flexibility in Language and Thought

    Science.gov (United States)

    Srinivasan, Mahesh

    2011-01-01

    Many words can be used flexibly: a book can be physically heavy, but also have provocative content, a "chicken" might live in a coop, but could also be tasty to eat. What do the uses of "polysemous" words such as these reveal about the structure of language and thought? Paper 1 examined 4-year-old children's representations of polysemous words…

  13. Creep behaviour of flexible adhesives

    NARCIS (Netherlands)

    Straalen, IJ.J. van; Botter, E.; Berg, A. van den; Beers, P. van

    2004-01-01

    Since flexible adhesives are used more and more in structural applications, designers should have a better understanding of its behaviour under various conditions as ultimate load, fatigue load, long-term load and environmental conditions. This paper focuses on long-term load conditions and its effe

  14. Flexible working motivates all staff.

    Science.gov (United States)

    2001-04-01

    A recent survey has demolished the myth that work-life balance is only of interest to women with children. The survey, commissioned by Lloyds TSB on behalf of the Employers for Work Life Balance organisation, shows that young workers and men are equally interested in flexible working arrangements that allow them to pursue interests outside of work.

  15. Flexible fixation and fracture healing

    DEFF Research Database (Denmark)

    Schmal, Hagen; Strohm, Peter C; Jaeger, Martin

    2011-01-01

    to the bone surface than external fixator bars. External fixators have the advantage of being less expensive, highly flexible, and technically less demanding. They remain an integral part of orthopaedic surgery for emergent stabilization, for pediatric fractures, for definitive osteosynthesis in certain...

  16. Drops spreading on flexible fibers

    Science.gov (United States)

    Somszor, Katarzyna; Boulogne, François; Sauret, Alban; Dressaire, Emilie; Stone, Howard

    2015-11-01

    Fibrous media are encountered in many engineered systems such as textile, paper and insulating materials. In most of these materials, fibers are randomly oriented and form a complex network in which drops of wetting liquid tend to accumulate at the nodes of the network. Here we investigate the role of the fiber flexibility on the spreading of a small volume of liquid on a pair of crossed flexible fibers. A drop of silicone oil is dispensed at the point of contact of the fibers and we characterize the liquid morphologies as we vary the volume of liquid, the angle between the fibers, and the length and bending modulus of the fibers. Drop morphologies previously reported for rigid fibers, i.e. a drop, a column and a mixed morphology, are also observed on flexible fibers with modified domains of existence. Moreover, at small inclination angles of the fibers, a new behavior is observed: the fibers bend and collapse. Depending on the volume, the liquid can adopt a column or a mixed morphology on the collapsed fibers. We rationalize our observations with a model based on energetic considerations. Our study suggests that the fiber flexibility adds a rich variety of behaviors that can be crucial for industrial applications.

  17. FLEXIBLE FLATFOOT IN CHILDREN (REVIEW

    Directory of Open Access Journals (Sweden)

    Владимир Маркович Кенис

    2014-06-01

    Full Text Available Flatfoot is one of the most common musculoskeletal conditions in the daily practice of pediatric orthopedists. Despite of numerous studies, diagnostic criteria and principles of management remain controversial. Flexible flatfoot - is visually detectable decrease in the height of the longitudinal arch of the foot, which can be spontaneously corrected by active or passive motion and not accompanied by any contracture of foot and ankle. Flexible flatfoot is a benign condition which is normal for childhood. But this term is also used to describe a painful deformity with marked limitation of dorsiflection and “not physiological” flatfoot with unfavorable course and prognosis. Despite of the awareness of the parents, flexible flatfoot does not lead to pain and should not be followed by any kind of treatment. Special shoe modifications and orthopedic insoles are useless in the attempt to improve the foot, but can influence negatively psychological condition and self-estimation. Proper diagnosis of flexible flatfoot is necessary in order to avoid unnecessary treatment and to reveal patients with adverse prognosis and rigid forms of flatfoot which need special approach.

  18. Functional flexibility and team performance

    NARCIS (Netherlands)

    Molleman, E.; Slomp, J.

    1999-01-01

    This study deals with workforce flexibility defined in terms of 'multifunctionality' and 'redundancy'. These concepts refer, respectively, to the number of different tasks a worker has mastered and the number of workers that are qualified to do a specific task. A third factor to be considered is wor

  19. Taming Time with Flexible Work.

    Science.gov (United States)

    Stamps, David

    1995-01-01

    Because of increasing incidence of burnout among midlevel managers, many companies are reducing workload schedules, an arrangement that would have been unthinkable 10 years ago. Surveys have made the case that flexible work arrangements increase employee happiness and, therefore, productivity. (JOW)

  20. Protein stability, flexibility and function

    DEFF Research Database (Denmark)

    Teilum, Kaare; Olsen, Johan G; Kragelund, Birthe B

    2011-01-01

    Proteins rely on flexibility to respond to environmental changes, ligand binding and chemical modifications. Potentially, a perturbation that changes the flexibility of a protein may interfere with its function. Millions of mutations have been performed on thousands of proteins in quests for a de......Proteins rely on flexibility to respond to environmental changes, ligand binding and chemical modifications. Potentially, a perturbation that changes the flexibility of a protein may interfere with its function. Millions of mutations have been performed on thousands of proteins in quests...... for a delineation of the molecular details of their function. Several of these mutations interfered with the binding of a specific ligand with a concomitant effect on the stability of the protein scaffold. It has been ambiguous and not straightforward to recognize if any relationships exist between the stability...... of a protein and the affinity for its ligand. In this review, we present examples of proteins where changes in stability results in changes in affinity and of proteins where stability and affinity are uncorrelated. We discuss the possibility for a relationship between stability and binding. From the data...

  1. Easy and flexible mixture distributions

    DEFF Research Database (Denmark)

    Fosgerau, Mogens; Mabit, Stefan L.

    2013-01-01

    We propose a method to generate flexible mixture distributions that are useful for estimating models such as the mixed logit model using simulation. The method is easy to implement, yet it can approximate essentially any mixture distribution. We test it with good results in a simulation study...

  2. 新生代农民工诚信问题研究%Study on Credibility of the New Generation of Migrant Workers

    Institute of Scientific and Technical Information of China (English)

    冯玲

    2011-01-01

    Combined with the characteristics of current generation of migrant workers, and in response to the credibility of new generation migrant workers, some constructive advices on the credibility education of new generation migrant workers were proposed so as to improve the competitiveness of careers, expand the space, and enhance the stability of employment.%结合现阶段时新生代农民工的特点,针对新生代农民工诚信问题进行分析,提出现阶段对新生代农民工诚信教育的政策性建议,以期提高新生代农民工择业的竞争力,拓宽发展空间,增强就业的稳定性.

  3. A Field Programmable Gate Array-Based Reconfigurable Smart-Sensor Network for Wireless Monitoring of New Generation Computer Numerically Controlled Machines

    Directory of Open Access Journals (Sweden)

    Ion Stiharu

    2010-08-01

    Full Text Available Computer numerically controlled (CNC machines have evolved to adapt to increasing technological and industrial requirements. To cover these needs, new generation machines have to perform monitoring strategies by incorporating multiple sensors. Since in most of applications the online Processing of the variables is essential, the use of smart sensors is necessary. The contribution of this work is the development of a wireless network platform of reconfigurable smart sensors for CNC machine applications complying with the measurement requirements of new generation CNC machines. Four different smart sensors are put under test in the network and their corresponding signal processing techniques are implemented in a Field Programmable Gate Array (FPGA-based sensor node.

  4. Towards a new generation of flow and transport models for the Aespoe Hard Rock Laboratory. Main results from the project Aespoe models 2005

    Energy Technology Data Exchange (ETDEWEB)

    Svensson, Urban (ed.) (Computer-aided Fluid Engineering AB (CFE AB), SE-602 10 Norrkoeping (Sweden)); Vidstrand, Patrik (Bergab AB, Goeteborg (Sweden)); Neretnieks, Ivars (Dept. of Chemical Engineering and Technology, Royal Inst. of Technology, Stockholm (Sweden)); Wallin, Bill (Geokema, Lidingoe (Sweden))

    2008-05-15

    This report constitutes the outcome of a project called 'Aespoe models 2005'. The main objective of the project has been to provide a first step towards a new generation of numerical models of flow and transport, for the Aespoe HRL. In order to achieve this goal, work has been carried out along three parallel lines; discussion of basic concepts, compilation and analysis of data and model applications. A number of sub tasks are reported as appendices in the report. In fact, these appendices represent the main achievements of the project: an analysis of fracture properties, compilation of isotope and chemical data, dispersion and mixing in fractured rocks and model results. The conclusion of the project is that significant contributions to a new generation of Aespoe models have been obtained. It has further been demonstrated that working numerical simulations are up and running. Recommendations are provided for the continued work

  5. 新一代Web技术的发展及其应用%Developments and Applications of the New Generation Web Technology

    Institute of Scientific and Technical Information of China (English)

    陈凯

    2012-01-01

    Faced with the rapid development of the Intemet and the popularity of multimedia applications, a new generation of Web standards HTML5 came into being and is accelerating the development and perfection. Through analysis of the evolution process of the Web technology, this paper mainly discusses the new generation of Web technology developments and the applications based HTML5.%面对互联网发展的突飞猛进以及多媒体应用的普及,新一代的Web标准HTML5应运而生并正加速发展和完善。本文通过分析Web技术的演进过程,阐述了以HTML5为主的新一代Web技术的发展状况和应用情况。

  6. The New Generation Cultural Analysis of Influence Factors to Migrant Workers%新生代农民工文化适应影响因素分析

    Institute of Scientific and Technical Information of China (English)

    邹显林

    2012-01-01

    从个人的发展愿景、自身的适应能力、现实的情感氛围及外部的环境因素等四大方面分析新生代农民工文化适应的影响因素,以帮助新生代农民工尽快融入城市,顺利融入社会。%In this paper, the new generation of their cultural adapt to the factors affecting the thorough analysis, mainly including the development of personal vision, their ability to adapt to the emotional atmosphere, reality and external environment factors four aspects, in order to help rural migrant workers in cities as soon as possible the new generation, smoothly into society.

  7. A Study on the Institutions Supply of New Generation Migrant Workers' Training%新生代农民工培训的制度供给研究

    Institute of Scientific and Technical Information of China (English)

    袁小平; 陈定元

    2012-01-01

      The traditional employment orientation to the new generation of migrant workers training institution can not solve the problems of the new generation of migrant workers in the city, be-cause the only highlight the migrant workers groups of occupation skill training, To establish the ability to guide for the characteristics of the novel of new generation of migrant workers training system needs to strengthen the system construction. To supply content should enrich the training content, increase the social aspects, in the main supply should improve the policy supply level, and strengthening the government responsibility, the supply way should be enacted as soon as the new generation of migrant workers training laws, improve in-stitutional authority.%  传统就业导向的新生代农民工培训制度由于只突出农民工群体的职业技能训练,不能解决新生代农民工群体的城市融入问题。要建立起以能力导向为特征的新型新生代农民工培训体系需要加强制度建设。在供给内容上应丰富培训的内容,增加社会适应等方面的内容,在供给主体上应提升目前政策供给主体的级别,并强化省级政府的责任,在供给方式上应尽快制定新生代农民工培训的法律,提高制度的权威性。

  8. 新生代农民工就业影响因素及其对策%Impact Factors and Countermeasures of New Generation of Migrant Workers Employment

    Institute of Scientific and Technical Information of China (English)

    樊欣欣

    2012-01-01

    新生代农民工就业的影响因素主要有:城乡二元户籍、城市社会排斥、市场竞争激烈、素质技能不足、培训体系不健全、就业途径不畅、就业保障受歧视、维权难等。当前促进新生代农民工就业的对策主要有:消除就业二元化制度壁垒、优化新生代农民工就业环境、扩大新生代农民工就业渠道、提升新生代农民工择业水准、加强职业技能培训、完善新生代农民工社会保障体系、提高新生代农民工维权意识和增强新生代农民工的就业归属感。%Some factors impact the migrant workers employment, which are: the household registration urban social exclusion, and fierce market competition, the lack of quality of the skills, the imperfect training system way, employment security by discrimination, activity difficulties. Countermeasures to promote the generation of migrant workers employment are: to eliminate barriers to employment dualistic system; to optimize the generation of migrant workers employment environment; to expand employment channels of the new generation of migrant workers; to enhance the career level of the new generation of migrant workers; to strengthen vocational skills training; to perfect the social security system of the new generation of migrant workers; to improve awareness of the new generation of Protecting Migrant Workers; and to enhance employment generation of migrant workers a sense of belonging.

  9. On the Issues of New Generation Migrant Workers' Employment Training%新生代农民工就业培训问题的思考

    Institute of Scientific and Technical Information of China (English)

    索志林; 罗莎

    2012-01-01

    The new generation of migrant workers has become the main body of the migrant workers and the important force to the construction of modernization in China. Improving their ability and quality is not only benefitial for themselves, but has the great significance for building the harmonious society and accelerating new rural construction. Therefore, based on the analysis of the new generation of migrant workers' characteristics and current quality status, the article dissects the factors of restricting employment training, and puts forward some suggestions to promote the employment training, in order to propel the new generation of migrant workers achieve full employment.%新生代农民工已成为农民工的主体,成为我国现代化建设的重要力量。其能力与素质的提高不仅对自身有利,更对构建和谐社会、加快新农村建设具有重大意义。在分析新生代农民工特征和素质现状的基础上,剖析制约其就业培训的因素,提出促进就业培训的若干建议,以期推动新生代农民工实现充分就业。

  10. 新生代农民工市民化的困境%Plight and Countermeasures for the New Generation of Migrant Workers City Residents

    Institute of Scientific and Technical Information of China (English)

    施必鸿

    2011-01-01

    新生代农民工市民化面临巨大的困境。促进新生代农民工市民化的途径包括:消除城乡二元体制,实现城乡一体化;落实公民平等权利,推进基本公共服务均等化;更新观念,消除认识障碍;促进就业,保障新生代农民工的劳动权;加大教育培训力度,提升新生代农民工的发展能力。%The new generation of migrant workers face enormous difficulties. The approaches of promoting the generation of migrant workers include: the elimination of urban-rural dual structure, rural and urban integration; implementation of the equal rights of citizens and the equalization of basic public services; the elimination of new ideas and achknowledge barriers; employment promoting, new generation of migrant workers labor rights; education training to enhance the development capacity of the new generation of migrant workers.

  11. The Analysis of Integration into Society About New- generation Migrant Workers%新生代农民工社会融入分析

    Institute of Scientific and Technical Information of China (English)

    张琦

    2012-01-01

    In recent years, the intergenerational differences within the migrant workers have been formed, with the new generation becoming the main force among this group, this new generation has formed its own charac- teristics. As a very active force in the integration process,whether they can form a positive integrative relation- ship with the city dwellers and thus become fully integrated into the city is an important factor in their urbani- zation,which will affect the effective construction of a harmonious socialist soliety, this article analyzes the ob- stacles involved in social integration as well as the characteristics of the new generation immigrant workers.%近年来,城市农民工群体内部的代际分化已经形成,新生代农民工成为农民工群体的主力。这一群体形成了自己的特点,在社会融入中表现最为积极,他们能否与城市居民进行良好的互动、融入到城市中去是城市化进程中的一个重要影响因素,关系到社会主义和谐社会的构建。文章从新生代农民工的特点、社会融入障碍等方面对其进行研究和分析。

  12. 新生代农民工市民化问题研究%Study on the Urbanization of New Generation Migrant Workers

    Institute of Scientific and Technical Information of China (English)

    冯海霞; 刘养卉

    2014-01-01

    The new generation migrant workers' urbanization is good for the final solution of “the issue of agricul-ture, rural areas and farmers” in China, speeding up the process of urbanization, building a harmonious society. To promote the new generation migrant workers'urbanization, the government, enterprises and society should make efforts that the government should perfect the relevant laws and regulations, enterprises should fulfill social respon-sibility and protect the legitimate rights and interests of the new generation of migrant workers, and society should provide a strong social supporting system.%新生代农民工市民化有利于我国“三农”问题的最终解决、城市化进程的加快、和谐社会的构建。促进新生代农民工市民化应从政府、企业和社会三个层面做出努力,政府应完善相关的法律法规,企业应履行社会责任,保障新生代农民工的合法权益及社会应提供强有力的社会支持系统等。

  13. Integrated flexible capacity and inventory management under flexible capacity uncertainty

    OpenAIRE

    Paç, Mehmet Fazıl

    2006-01-01

    Cataloged from PDF version of article. In a manufacturing environment with volatile demand, inventory management can be coupled with dynamic capacity adjustments for handling the fluctuations more effectively. In this study we consider the integrated management of inventory and flexible capacity management under seasonal stochastic demand and uncertain labor supply. The capacity planning problem is investigated from the workforce planning perspective. We consider a manufactu...

  14. The Ethical Viewpoint on Labor Shortage---Research on the Dilemma in the Management of the New Generation of Migrant Works in SMEs%“用工荒”的伦理审视--对中小企业新生代农民工管理困境的分析

    Institute of Scientific and Technical Information of China (English)

    唐凯麟; 姜珂

    2015-01-01

    Labor shortages,existed in the SMEs (small and medium-sized enterprises),is a very complicated social issue.According to the ethical view,the SMEs should implement the flexible management measures and solve the prob-lems between the SMEs and the new generation of migrant works in a more proper way. The consciousness of social re-sponsibility,the lack of humanistic care,social discrimination against the new generation of migrant works,unfair distri-bution,and ethical disorder are all the problems that exist in the SMEs. Using the ehical management methods to con-quer these kind of problems is the unique way for the SMEs to achieve the sustainable development.%中小企业面临的“用工荒”问题,是一个综合性的社会问题。从伦理视角出发,实施柔性管理,有针对性地解决新生代农民工和中小企业之间的矛盾,并克服中小企业社会责任意识淡薄、缺乏人文关怀、存在社会歧视、分配不公现象和企业内部伦理缺失等问题,是实现中小企业可持续发展的重要途径。

  15. The Problems of Research on Group Identity of New Generation of Migrant Workers%新生代农民工群体特征研究

    Institute of Scientific and Technical Information of China (English)

    迟帅; 金银

    2012-01-01

    自2010年中央一号文件首次提出“新生代农民工”说法,新生代农民工开始成为社会各界关注的对象,通过梳理相关文献大致可勾画出新生代农民工所谓“四高”、“一低”、“一薄弱”的社会印象和群体特征。相对其他群体来说,新生代农民工受教育水平并不高,对于农民身份认同相对减弱,城市社区认同较高。对于新生代农民工群体特征的研究应该区分农民工的人口学特征与社会特征,并充分认识到新生代农民工群体的异质性,对其定义和特征把握要注意从与周围群体和代际关系中共同考虑。%Since 2010, the No.1 document of central government named "the new generation of migrant workers" for the first time. The new generation of migrant workers draws on public attention. As to the concept, this paper gives the proper reflection of the deviations in the series of researches and its prevention, and sketches out the social impression of the new generation of migrant workers and group identity, such as higher levels of education, higher career expectations, higher level of consumption, higher level of social security; low work tolerance; weak provincialism. Compared to other groups, the new generation of migrant workers is not highly educated. Their peasant identity was weakened and urban community identity was strengthened. Finally, the demographic and social characteristics of the group identity of the new generation of migrant workers should be distinguished and the heterogeneity should be fully paid attention to. And we should consider the characteristics from the surrounding community and intergenerational relationship together.

  16. 系统评价非复杂性输尿管镜碎石术后不安置D-J管的可行性与有效性%Systematic review on feasibility and validity of non-D-J tube placement following uncomplicated ureteroscopic lithotripsy

    Institute of Scientific and Technical Information of China (English)

    钟强; 姜庆; 郑昌建; 赵春雷; 林艳君

    2012-01-01

    Objective To systematically review the feasibility and the validity of non-D-J tube placement following ureteroscopic litho-tripsy for ureteral calculi. Methods All randomized clinical trials of non-D-J tube placement after ureteroscopic lithotripsy were identified with Cochrane Library、PubMed、Embase、VIP、WangFang and CNKI. The quality of the included randomized trials and extracted data was assessed by two reviewers independently. Meta analysis was performed with RevMan 5. 0 soft ware. Results Twelve randomized trials ( including 1 071 patients ) were collected and divided into test group ( non-D-J tube placement ) and control group ( D-J tube placement ). The me-ta-analysis showed that the operation time was shortened in test group ( P =0. 000 2 ), the risk of postoperative frequent /urgent micturition was decreased by 41% , ( P <0. 000 01 ), hematuria by 51% (P = 0.007) and dysuria by 48%( P =0. 008 ) compared with those in control group. There was no statistical difference in mean hospital duration, stone discharge rate and postoperative ureterostenosis between test and control group ( P =0. 16 ). Conclusion Non-D-J tube placement after ureteroscopic lithotripsy is better than D-J tube placement in operation duration and postoperative complication,howerver, it has no influence on mean hospital time, stone discharge rate and postoperative ureterostenosis.%目的 系统评价非复杂输尿管镜下输尿管结石碎石术后不安置D-J管的可行性与有效性.方法 检索Cochrane Library、PubMed、EMbase、维普、万方及CNKI等在线数据库,搜索相关的所有随机对照试验,由两位评价员独立进行评价和资料提取,统计学分析采用RevMan 5.0软件处理.结果 共纳入12个随机对照试验(共1 071例),分为试验组(不安置D-J管)和对照组(安置D-J管),Meta分析结果显示,与对照组比较,试验组的手术时间短(P=0.000 2),术后尿频/尿急的发生风险减少了41%(P<0.000 01),

  17. Research of perioperative nursing for upper urinary tract calculi treated by C-arm X-ray guided ;percutaneous nephroscope and ureteroscope%C型臂X线定位经皮肾输尿管镜治疗上尿路结石的围手术期护理研究

    Institute of Scientific and Technical Information of China (English)

    潘萍; 李燕玲

    2015-01-01

    目的:研究C型臂X线定位经皮肾输尿管镜治疗上尿路结石的围手术期护理。方法50例上尿路结石患者,采用随机数字表法分为护理组与对照组,各25例。两组患者均采取X线定位下经皮肾镜、输尿管镜治疗上尿路结石,对照组患者采取临床基础护理措施,护理组患者在对照组护理基础上进行综合护理干预,比较两组各项临床指标。结果护理组患者手术用时、住院时间、术后并发症发生率均低于对照组(P<0.05);一次性结石清除率高于对照组(P<0.05)。结论对于C型臂X线定位经皮肾镜、输尿管镜治疗上尿路结石手术患者采取综合护理干预可显著提高患者一次性结石清除率,有助于降低术中、术后疼痛情况及手术并发症,具有临床应用及推广价值。%Objective To research perioperative nursing for upper urinary tract calculi treated by C-arm X-ray guided percutaneous renal ureteroscope. Methods A total of 50 upper urinary tract calculi patients were divided by random number table into nursing group and control group, with 25 cases in each group. Both groups received C-arm X-ray guided p percutaneous nephroscope and ureteroscope for treatment. The control group received basic clinical nursing measures, and the nursing group received additional comprehensive nursing intervention. Clinical indexes of the two groups were compared. Results The nursing group had all lower operation time, hospital stay, and incidence of postoperative complications than the control group (P<0.05), and it had higher one-time calculi clearance rate than the control group (P<0.05). Conclusion Implement of comprehensive intervention for upper urinary tract calculi treated by C-arm X-ray guided percutaneous renal ureteroscope can remarkably improve one-time calculi clearance rate, and it is helpful to reducing intraoperative and postoperative pain and postoperative complications. This method contains value of

  18. WAGE FLEXIBILITY IN THE CONTEMPORARY SOCIETY

    Directory of Open Access Journals (Sweden)

    TECULESCU Silviu Alexandru

    2010-12-01

    Full Text Available The paper follows to offer the most efficient solutions for the attainment by Romania of the economic development level associated to the Western European countries. It proposes the division of the flexibility of labour market in three components, namely: internal flexibility, external flexibility and wage flexibility. The analysis performed within the present study will emphasize the wage flexibility. Wage flexibility can be classified in four components: a plans of individual and group incentives; b plans of assigning wages out of productivity; c plans of distribution of profits and, respectively, d plans of suggestions. The labour market flexibility, in general, and especially the wage flexibility contributes to the increase of employee motivation at the workplace, aspect which leeds to the growth of labour productivity, through this one being put the bases of the medium- and long-term economic development.

  19. ULTRA BARRIER TOPSHEET (UBT) FOR FLEXIBLE PHOTOVOLTAICS

    Energy Technology Data Exchange (ETDEWEB)

    DeScioli, Derek

    2013-06-01

    This slide-show presents 3M photovoltaic-related products, particularly flexible components. Emphasis is on the 3M Ultra Barrier Solar Films. Topics covered include reliability and qualification testing and flexible photovoltaic encapsulation costs.

  20. Understanding flexible and distributed software development processes

    OpenAIRE

    Agerfalk, Par J.; Fitzgerald, Brian

    2006-01-01

    peer-reviewed The minitrack on Flexible and Distributed Software Development Processes addresses two important and partially intertwined current themes in software development: process flexibility and globally distributed software development

  1. Flexible Temperature Sensors on Fibers

    Directory of Open Access Journals (Sweden)

    Marcin Sloma

    2010-08-01

    Full Text Available The aim of this paper is to present research dedicated to the elaboration of novel, miniaturized flexible temperature sensors for textronic applications. Examined sensors were manufactured on a single yarn, which ensures their high flexibility and good compatibility with textiles. Stable and linear characteristics were obtained by special technological process and applied temperature profiles. As a thermo-sensitive materials the innovative polymer compositions filled with multiwalled carbon nanotubes were used. Elaborated material was adapted to printing and dip-coating techniques to produce NTC composites. Nanotube sensors were free from tensometric effect typical for other carbon-polymer sensor, and demonstrated TCR of 0.13%/K. Obtained temperature sensors, compatible with textile structure, can be applied in rapidly developing smart textiles and be used for health and protections purposes.

  2. Flexible spintronic devices on Kapton

    DEFF Research Database (Denmark)

    Bedoya-Pinto, Amilcar; Donolato, Marco; Gobbi, Marco;

    2014-01-01

    of bending angle (r = 5 mm) have been achieved without degradation of the device performance, reaching room-temperature tunneling magnetoresistance ratios of 12% in bended Co/Al2O3/NiFe junctions. In addition, a suitable route to pattern high-quality nanostructures directly on the polyimide surface......Magnetic tunnel junctions and nano-sized domain-wall conduits have been fabricated on the flexible substrate Kapton. Despite the delicate nature of tunneling barriers and zig-zag shaped nanowires, the devices show an outstanding integrity and robustness upon mechanical bending. High values...... is established. These results demonstrate that Kapton is a promising platform for low-cost, flexible spintronic applications involving tunnel junction elements and nanostructurization. ...

  3. Thin, Flexible IMM Solar Array

    Science.gov (United States)

    Walmsley, Nicholas

    2015-01-01

    NASA needs solar arrays that are thin, flexible, and highly efficient; package compactly for launch; and deploy into large, structurally stable high-power generators. Inverted metamorphic multijunction (IMM) solar cells can enable these arrays, but integration of this thin crystalline cell technology presents certain challenges. The Thin Hybrid Interconnected Solar Array (THINS) technology allows robust and reliable integration of IMM cells into a flexible blanket comprising standardized modules engineered for easy production. The modules support the IMM cell by using multifunctional materials for structural stability, shielding, coefficient of thermal expansion (CTE) stress relief, and integrated thermal and electrical functions. The design approach includes total encapsulation, which benefits high voltage as well as electrostatic performance.

  4. The evolution of flexible parenting.

    Science.gov (United States)

    Royle, Nick J; Russell, Andrew F; Wilson, Alastair J

    2014-08-15

    Parenting behaviors, such as the provisioning of food by parents to offspring, are known to be highly responsive to changes in environment. However, we currently know little about how such flexibility affects the ways in which parenting is adapted and evolves in response to environmental variation. This is because few studies quantify how individuals vary in their response to changing environments, especially social environments created by other individuals with which parents interact. Social environmental factors differ from nonsocial factors, such as food availability, because parents and offspring both contribute and respond to the social environment they experience. This interdependence leads to the coevolution of flexible behaviors involved in parenting, which could, paradoxically, constrain the ability of individuals to rapidly adapt to changes in their nonsocial environment. Copyright © 2014, American Association for the Advancement of Science.

  5. Advanced solderless flexible thermal link

    Science.gov (United States)

    Williams, Brian G.; Jensen, Scott M.; Batty, J. Clair

    1996-10-01

    Flexible thermal links play an important role int he thermal management of cryogenically cooled components. The purpose of these links is to provide a means of transferring heat from a cooled component to a cooler reservoir with little increase in temperature. The standard soldered approach although effective proves to be time consuming and contributes to added thermal impedances which degrade the performance of the link. For system with little tolerance for temperature differences between cooled components and a cooling source this is undesirable. The authors of this paper have developed a technique by which thin metal foil or braided wire can be attached to metal end blocks without any solder using the swaging process. Swaging provides a fast, simple method for providing a low thermal impedance between the foils and blocks. This paper describes the characteristics of these thermal links in terms of length, mass, thermal resistance, flexibility, and survivability.

  6. Lost and Found in Flexibility

    DEFF Research Database (Denmark)

    Bødker, Susanne; Christiansen, Ellen

    2002-01-01

    'New work' is characterized by mobility and flexibility and a growing need to facilitate social awareness. The paper discusses how to augment the environment with social awareness and suggest 'awareness-in-transition' as a lable for awareness in mobile work in flexible work environments, and as l...... studies, the authors develop a requirements specification framework and a revised list of challenges for developers of Information Systems that support social awareness in 'New work'......., and as locus for building social awareness in the 'new work'. A transition (e.g. taking information from a whiteboard in a meeting room to the desktop of a personal computer)--besides the immediate implications at the functional level--has important interpersonal, intra-personal, and organizational...

  7. Superhydrophobicity enhancement through substrate flexibility.

    Science.gov (United States)

    Vasileiou, Thomas; Gerber, Julia; Prautzsch, Jana; Schutzius, Thomas M; Poulikakos, Dimos

    2016-11-22

    Inspired by manifestations in nature, microengineering and nanoengineering of synthetic materials to achieve superhydrophobicity has been the focus of much work. Generally, hydrophobicity is enhanced through the combined effects of surface texturing and chemistry; being durable, rigid materials are the norm. However, many natural and technical surfaces are flexible, and the resulting effect on hydrophobicity has been largely ignored. Here, we show that the rational tuning of flexibility can work synergistically with the surface microtexture or nanotexture to enhance liquid repellency performance, characterized by impalement and breakup resistance, contact time reduction, and restitution coefficient increase. Reduction in substrate areal density and stiffness imparts immediate acceleration and intrinsic responsiveness to impacting droplets (∼350 × g), mitigating the collision and lowering the impalement probability by ∼60% without the need for active actuation. Furthermore, we exemplify the above discoveries with materials ranging from man-made (thin steel or polymer sheets) to nature-made (butterfly wings).

  8. Flexible Adaptation in Cognitive Radios

    CERN Document Server

    Li, Shujun

    2013-01-01

    This book provides an introduction to software-defined radio and cognitive radio, along with methodologies for applying knowledge representation, semantic web, logic reasoning and artificial intelligence to cognitive radio, enabling autonomous adaptation and flexible signaling. Readers from the wireless communications and software-defined radio communities will use this book as a reference to extend software-defined radio to cognitive radio, using the semantic technology described. Readers with a background in semantic web and artificial intelligence will find in this book the application of semantic web and artificial intelligence technologies to wireless communications. For readers in networks and network management, this book presents a new approach to enable interoperability, collaborative optimization and flexible adaptation of network components. Provides a comprehensive ontology covering the core concepts of wireless communications using a formal language; Presents the technical realization of using a ...

  9. Flexible pile thermal barrier insulator

    Science.gov (United States)

    Anderson, G. E.; Fell, D. M.; Tesinsky, J. S. (Inventor)

    1978-01-01

    A flexible pile thermal barrier insulator included a plurality of upstanding pile yarns. A generally planar backing section supported the upstanding pile yarns. The backing section included a plurality of filler yarns forming a mesh in a first direction. A plurality of warp yarns were looped around said filler yarns and pile yarns in the backing section and formed a mesh in a second direction. A binder prevented separation of the yarns in the backing section.

  10. CRISIS FOCUS Uncertainty and Flexibility

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    As the world continued to watch the unfolding financial and economic crises this month, Robert Zoellick, President of the World Bank, arrived in China for discussions on how the country can help support the global economy and the efforts it has taken to strengthen its own recovery. Zoellick, who had seen many uncertainties in 2009, called for China to be flexible with its macroeconomic policy. He made the following comments at a press conference in Beijing on December 15. Edited excerpts follow:

  11. Organisationsprinzipien zielgerichteter Bewegungen flexibler Greiforgane

    OpenAIRE

    Martin, Franziska

    2010-01-01

    Flexible grasping organs like the trunk of elephants and the grasping tail of spider monkeys have to deal with a high degree of movement freedom in their goal-directed movements. The aim of this study was to find the basic organisation principles they apply in order to lower the coordination expense of their movements. Therefore, in hypothesis I a reduction of the degree of movement freedom was postulated whereas hypothesis II assumed a specialization of movements towards one side. Since trun...

  12. Flexible Photonic Cellulose Nanocrystal Films

    OpenAIRE

    Guidetti, G.; Atifi, S; Vignolini, S; Hamad, WY

    2016-01-01

    The fabrication of self-assembled cellulose nanocrystal (CNC) films of tunable photonic and mechanical properties using a facile, green approach is demonstrated. The combination of tunable flexibility and iridescence can dramatically expand CNC coating and film barrier capabilities for paints and coating applications, sustainable consumer packaging products, as well as effective templates for photonic and optoelectronic materials and structures. CelluForce Inc., Biotechnology and Biologica...

  13. Flexible Execution of Cognitive Procedures.

    Science.gov (United States)

    1987-06-30

    Rosenbloom. P. (1988). Symbolic Architectures. In Posner, M. (Ed.), FoundatiCns of Cogniive Science . Cambridge. MKA MIT Press. In preparation. Nii. P. , 1986...Procedures 00 Technical Report PCG-5 14 Kurt VanLehn and William Ball Departments of Psychology and Computer Science Carnegie-Mellon University...Psychology and Computer Science Carnegie-Mellon University Pittsburgh, PA 15213 U.S.A 30 June 1987 Running head: Flexible Execution of Cognitive

  14. Flexible manufacturing system (FMS) evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Setter, D.L.

    1993-02-01

    The applicability of the flexible manufacturing system (FMS) concept to automate machining and inspecting a family of stainless steel and aluminum hardware for electrical components has been evaluated. FMS was found to be appropriate and justifiable and a project was initiated to purchase and implement an FMS system. System specifications and procurement methodologies were developed that resulted in a conventional competitive bid procurement A proposal evaluation technique was developed consisting of 40% price, 40% technical compliance, and 20% supplier management capabilities.

  15. UNITY OF THE ORGANIZATIONAL FUNCTIONS FLEXIBILITY

    OpenAIRE

    George MOLDOVEANU; Cosmin DOBRIN

    2012-01-01

    The paper has the goal to analyse the correlation of the flexibility of all organizational functions. Based upon theoretical and practical studies, the decrease of flexibility into an "activity area" of organizations implies a diminution on a large scale of the flexibility of the processing system as a law expression of the decreasing outputs within economy. Therefore, at the level of each organizational function there are several major directions ensuring the flexibility of the "ensemble".

  16. Design of satellite flexibility experiments

    Science.gov (United States)

    Kaplan, M. H.; Hillard, S. E.

    1977-01-01

    A preliminary study has been completed to begin development of a flight experiment to measure spacecraft control/flexible structure interaction. The work reported consists of two phases: identification of appropriate structural parameters which can be associated with flexibility phenomena, and suggestions for the development of an experiment for a satellite configuration typical of near-future vehicles which are sensitive to such effects. Recommendations are made with respect to the type of data to be collected and instrumentation associated with these data. The approach consists of developing the equations of motion for a vehicle possessing a flexible solar array, then linearizing about some nominal motion of the craft. A set of solutions are assumed for array deflection using a continuous normal mode method and important parameters are exposed. Inflight and ground based measurements are distinguished. Interrelationships between these parameters, measurement techniques, and input requirements are discussed which assure minimization of special vehicle maneuvers and optimization of data to be obtained during the normal flight sequence.

  17. [Flexibility and safety in hospitals].

    Science.gov (United States)

    Fara, G M; Barni, M

    2011-01-01

    The paper explains the reasons according to which the newly-planned hospitals must adopt the concept of advanced flexibility (structural, technological, organizational, diagnostic and therapeutic), in order to avoid the risk of being already obsolete at the moment of their opening, and this due to the fact that too much time elapses in this Country between the moment of planning a new hospital and the moment of the start of its activity. Flexibility is needed at different levels: at low or medium levels for what concerns administrative spaces and also patient rooms (except, in this latter case, when differential intensity of care is adopted); at advanced levelfor what concerns diagnostic and therapeutic areas, which must be rapidly adaptable to new solutions offered by advances in technology and organization. From a different standpoint, flexibility applies also to the fact that hospital must increasingly become a node of a large net including territorial health services: the latter devoted to take care of chronicity, while hospitals should concentrate on acute pathology. Of course the territory surrounding the hospital, through its outpatient service and consultories, is in charge also for first level diagnosy and therapy, leaving the hospital to more sophisticated activities.

  18. The Flexibility of Ectopic Lipids

    Directory of Open Access Journals (Sweden)

    Hannah Loher

    2016-09-01

    Full Text Available In addition to the subcutaneous and the visceral fat tissue, lipids can also be stored in non-adipose tissue such as in hepatocytes (intrahepatocellular lipids; IHCL, skeletal (intramyocellular lipids; IMCL or cardiac muscle cells (intracardiomyocellular lipids; ICCL. Ectopic lipids are flexible fuel stores that can be depleted by physical exercise and repleted by diet. They are related to obesity and insulin resistance. Quantification of IMCL was initially performed invasively, using muscle biopsies with biochemical and/or histological analysis. 1H-magnetic resonance spectroscopy (1H-MRS is now a validated method that allows for not only quantifying IMCL non-invasively and repeatedly, but also assessing IHCL and ICCL. This review summarizes the current available knowledge on the flexibility of ectopic lipids. The available evidence suggests a complex interplay between quantitative and qualitative diet, fat availability (fat mass, insulin action, and physical exercise, all important factors that influence the flexibility of ectopic lipids. Furthermore, the time frame of the intervention on these parameters (short-term vs. long-term appears to be critical. Consequently, standardization of physical activity and diet are critical when assessing ectopic lipids in predefined clinical situations.

  19. The Flexibility of Ectopic Lipids.

    Science.gov (United States)

    Loher, Hannah; Kreis, Roland; Boesch, Chris; Christ, Emanuel

    2016-09-14

    In addition to the subcutaneous and the visceral fat tissue, lipids can also be stored in non-adipose tissue such as in hepatocytes (intrahepatocellular lipids; IHCL), skeletal (intramyocellular lipids; IMCL) or cardiac muscle cells (intracardiomyocellular lipids; ICCL). Ectopic lipids are flexible fuel stores that can be depleted by physical exercise and repleted by diet. They are related to obesity and insulin resistance. Quantification of IMCL was initially performed invasively, using muscle biopsies with biochemical and/or histological analysis. ¹H-magnetic resonance spectroscopy (¹H-MRS) is now a validated method that allows for not only quantifying IMCL non-invasively and repeatedly, but also assessing IHCL and ICCL. This review summarizes the current available knowledge on the flexibility of ectopic lipids. The available evidence suggests a complex interplay between quantitative and qualitative diet, fat availability (fat mass), insulin action, and physical exercise, all important factors that influence the flexibility of ectopic lipids. Furthermore, the time frame of the intervention on these parameters (short-term vs. long-term) appears to be critical. Consequently, standardization of physical activity and diet are critical when assessing ectopic lipids in predefined clinical situations.

  20. 输尿管镜下尿道会师牵引术联合膀胱穿刺造瘘治疗尿道断裂15例临床体会%The Clinical Experience of Urethral Reunion Traction Operation in Ureteroscopic Combined with Bladder Puncture Fistulation to Treat 15 Cases of Urethral Disruption

    Institute of Scientific and Technical Information of China (English)

    廖国龙; 曾志宇; 吴子云; 曲仕浩; 朱黎; 江伟东

    2015-01-01

    Objective:To summarize the clinical experience of treating urethral disruption by urethral reunion traction operation in ureteroscope combined with bladder puncture fistulation.Method:15 cases with urethral disruption who received urethral reunion traction operation combined with bladder puncture fistulation were selected and the clinical data was summarized. Result:15 cases all successed,the mean operation time was(22±8)minutes,the amount of bleeding in operation was(18±4)mL,the average time of urethral sustained traction was(8±2)days,and the hospitalization time was(12±2)days.After a follow up of 12 months,the treatment effect was satisfactory,and no obvious urinary incontinence and erectile dysfunction.2 patients with dysuria were cured by urethral dilation. Conclusion:The operation of urethral reunion traction operation in ureteroscope combined with bladder puncture fistulation to treat urethral disruption is effective for treating urethral disruption and it is worth popularizing.%目的:总结输尿管镜下尿道会师牵引术联合膀胱穿刺造瘘治疗尿道断裂的临床体会。方法:急诊行输尿管镜下尿道会师牵引术联合膀胱穿刺造瘘治疗15例尿道断裂患者,总结其临床资料。结果:15例患者手术均获成功,手术时间平均(22±8)min,术中出血量平均(18±4)mL,尿管持续牵引平均(8±2)d,平均住院时间(12±2)d。术后随访12个月,治疗效果满意,未出现明显尿失禁及勃起功能损害。其中2例拔尿管后出现排尿困难,经定期尿道扩张后治愈。结论:输尿管镜下尿道会师牵引术联合膀胱穿刺造瘘治疗尿道断裂,操作简单,创伤小,术后恢复快,值得临床推广。