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Sample records for neutrino factory design

  1. Neutrino Factory

    CERN Document Server

    Bogomilov, M; Tsenov, R; Dracos, M; Bonesini, M; Palladino, V; Tortora, L; Mori, Y; Planche, T; Lagrange, J  B; Kuno, Y; Benedetto, E; Efthymiopoulos, I; Garoby, R; Gilardoini, S; Martini, M; Wildner, E; Prior, G; Blondel, A; Karadzhow, Y; Ellis, M; Kyberd, P; Bayes, R; Laing, A; Soler, F  J  P; Alekou, A; Apollonio, M; Aslaninejad, M; Bontoiu, C; Jenner, L  J; Kurup, A; Long, K; Pasternak, J; Zarrebini, A; Poslimski, J; Blackmore, V; Cobb, J; Tunnell, C; Andreopoulos, C; Bennett, J  R  J; Brooks, S; Caretta, O; Davenne, T; Densham, C; Edgecock, T  R; Fitton, M; Kelliher, D; Loveridge, P; McFarland, A; Machida, S; Prior, C; Rees, G; Rogers, C; Rooney, M; Thomason, J; Wilcox, D; Booth, C; Skoro, G; Back, J  J; Harrison, P; Berg, J  S; Fernow, R; Gallardo, J  C; Gupta, R; Kirk, H; Simos, N; Stratakis, D; Souchlas, N; Witte, H; Bross, A; Geer, S; Johnstone, C; Mokhov, N; Neuffer, D; Popovic, M; Strait, J; Striganov, S; Morfín, J  G; Wands, R; Snopok, P; Bogacz, S  A; Morozov, V; Roblin, Y; Cline, D; Ding, X; Bromberg, C; Hart, T; Abrams, R  J; Ankenbrandt, C  M; Beard, K  B; Cummings, M  A  C; Flanagan, G; Johnson, R  P; Roberts, T  J; Yoshikawa, C  Y; Graves, V  B; McDonald, K  T; Coney, L; Hanson, G

    2014-01-01

    The properties of the neutrino provide a unique window on physics beyond that described by the standard model. The study of subleading effects in neutrino oscillations, and the race to discover CP-invariance violation in the lepton sector, has begun with the recent discovery that $\\theta_{13} > 0$. The measured value of $\\theta_{13}$ is large, emphasizing the need for a facility at which the systematic uncertainties can be reduced to the percent level. The neutrino factory, in which intense neutrino beams are produced from the decay of muons, has been shown to outperform all realistic alternatives and to be capable of making measurements of the requisite precision. Its unique discovery potential arises from the fact that only at the neutrino factory is it practical to produce high-energy electron (anti)neutrino beams of the required intensity. This paper presents the conceptual design of the neutrino factory accelerator facility developed by the European Commission Framework Programme 7 EURO$\

  2. Neutrino factories

    International Nuclear Information System (INIS)

    Dydak, F.

    2002-01-01

    The discovery of neutrino oscillations marks a major milestone in the history of neutrino physics, and opens a window to what lies beyond the Standard Model. Many current and forthcoming experiments will answer open questions; however, a major step forward, up to and possibly including CP violation in the neutrino mixing matrix, will be offered by the neutrino beams from a neutrino factory. The neutrino factory is a new concept for producing neutrino beams of unprecedented quality in terms of intensity, flavour composition, and precision of the beam parameters. These beams enable the exploration of otherwise inaccessible domains in neutrino oscillation physics by exploiting baselines of planetary dimensions. Suitable detectors pose formidable challenges but seem within reach with only moderate extrapolations from existing technologies. Although the main physics attraction of the neutrino factory is in the area of neutrino oscillations, an interesting spectrum of further opportunities ranging from high-precision, high-rate neutrino scattering to physics with high-intensity stopped muons comes with it

  3. CrossRef Neutrino factory proton driver and target design

    CERN Document Server

    Garoby, Roland; Thomason, John; Davenne, Tristan; Caretta, Ottone; Back, John J

    2016-01-01

    Neutrinos are very elusive particles belonging to the lepton family. They exist in different types corresponding to the different charged leptons, namely electrons, muons and taus. Contrary to electrons, neutrinos hardly interact with matter which makes them very difficult to detect and study. To the best of today’s knowledge, neutrinos have hardly any mass and they can change from one type to another (so-called “neutrino oscillation”). Most physicists think that this oscillation occurs because neutrinos have mass. A Neutrino Factory [1] is a special facility producing a large amount of neutrinos every year (typically 10$^{21}$ neutrinos/year). Its main purpose is to study the change of type of neutrinos between the place where they are generated and a remote location. In a Neutrino Factory, neutrinos result from the decay of muons, unstable particles with a mean lifetime of 2.2 $\\mu$s in their rest frame. Sharp beams of high energy neutrinos are obtained at the end of the long straight sections of a mu...

  4. Neutrino Factory: status and prospects

    International Nuclear Information System (INIS)

    Long, K.

    2011-01-01

    The properties of the neutrino provide a unique window on physics beyond that described by the Standard Model. The study of sub-leading effects in neutrino oscillations has begun with the race to measure θ 13 consensus is emerging within the international community that a novel neutrino source is required to allow sensitive searches for leptonic CP violation to be carried out and the neutrino mass-hierarchy to be determined. The Neutrino Factory, in which intense neutrino beams are produced from the decay of muons, has been shown to out-perform the other proposed facilities. The physics case for the Neutrino Factory will be reviewed and the baseline design of the facility being developed by the International Design Study for the Neutrino Factory (the IDS-NF) collaboration will be described.

  5. Steps towards the Neutrino Factory

    International Nuclear Information System (INIS)

    Long, K.

    2012-01-01

    The properties of the neutrino provide a unique window on physics beyond that described by the Standard Model. The study of sub-leading effects in neutrino oscillations has begun with the race to measure θ 13 . A consensus is emerging within the international community that a novel neutrino source is required to allow sensitive searches for leptonic CP violation to be carried out and the neutrino mass-hierarchy to be determined. The Neutrino Factory, in which intense neutrino beams are produced from the decay of muons, has been shown to out-perform the other proposed facilities. The physics case for the Neutrino Factory will be reviewed and the baseline design of the facility being developed by the International Design Study for the Neutrino Factory (the IDS-NF) collaboration will be described.

  6. FFAG Designs for the International Design Study for the Neutrino Factory

    Energy Technology Data Exchange (ETDEWEB)

    Berg, J.S.; Machida, S.

    2009-05-04

    The International Design Study for the Neutrino Factory (IDS-NF) aims to produce a design report for a neutrino factory. One component of that design is a linear nonscaling fixed-field alternating gradient accelerator (FFAG) that will accelerate to the final energy of 25 GeV. An FFAG is used to reduce the machine cost by maximizing the number of passes made through the RF cavities. We present some design options for this FFAG, individually optimized for cost. We study the addition of nonlinear magnets to the lattice to improve the performance of the lattice and consider the negative effects of doing so.

  7. Muon colliders and neutrino factories

    Energy Technology Data Exchange (ETDEWEB)

    Geer, S.; /Fermilab

    2010-09-01

    Over the last decade there has been significant progress in developing the concepts and technologies needed to produce, capture and accelerate {Omicron}(10{sup 21}) muons/year. This development prepares the way for a new type of neutrino source (Neutrino Factory) and a new type of very high energy lepton-antilepton collider (Muon Collider). This article reviews the motivation, design and R&D for Neutrino Factories and Muon Colliders.

  8. Interim Design Report for the International Design Study for a Neutrino Factory

    International Nuclear Information System (INIS)

    Choubey, S.; Gandhi, R.; Goswami, S.; Berg, J.S.; Fernow, R.; Gallardo, J.C.; Gupta, R.; Kirk, H.; Simos, N.; Souchlas, N.; Ellis, M.

    2011-01-01

    The starting point for the International Design Study for the Neutrino Factory (the IDS-NF) was the output of the earlier International Scoping Study for a future Neutrino Factory and super-beam facility (the ISS). The accelerator facility described in section 2 incorporates the improvements that have been derived from the substantial amount of work carried out within the Accelerator Working Group. Highlights of these improvements include: (1) Initial concepts for the implementation of the proton driver at each of the three example sites, CERN, FNAL, and RAL; (2) Detailed studies of the energy deposition in the target area; (3) A reduction in the length of the muon beam phase-rotation and bunching systems; (4) Detailed analyses of the impact of the risk that stray magnetic field in the accelerating cavities in the ionization cooling channel will reduce the maximum operating gradient. Several alternative ionization-cooling lattices have been developed as fallback options to mitigate this technical risk; (5) Studies of particle loss in the muon front-end and the development of strategies to mitigate the deleterious effects of such losses; (6) The development of more complete designs for the muon linac and re-circulating linacs; (7) The development of a design for the muon FFAG that incorporates insertions for injection and extraction; and (8) Detailed studies of diagnostics in the decay ring. Other sub-systems have undergone a more 'incremental' evolution; an indication that the design of the Neutrino Factory has achieved a degree of maturity. The design of the neutrino detectors described in section 3 has been optimized and the Detector Working Group has made substantial improvements to the simulation and analysis of the Magnetized Iron Neutrino Detector (MIND) resulting in an improvement in the overall neutrino-detection efficiency and a reduction in the neutrino-energy threshold. In addition, initial consideration of the engineering of the MIND has generated a

  9. Interim Design Report for the International Design Study for a Neutrino Factory

    Energy Technology Data Exchange (ETDEWEB)

    Choubey, S.; Gandhi, R.; Goswami, S.; /Harish-Chandra Res. Inst.; Berg, J.S.; Fernow, R.; Gallardo, J.C.; Gupta, R.; Kirk, H.; Simos, N.; Souchlas, N.; /Brookhaven; Ellis, M.; /Brunel U. /CERN /Durham U., IPPP /Fermilab /Geneva U. /Glasgow U. /Heidelberg, Max Planck Inst. /Imperial Coll., London /Jefferson Lab /Saha Inst.

    2011-10-01

    The starting point for the International Design Study for the Neutrino Factory (the IDS-NF) was the output of the earlier International Scoping Study for a future Neutrino Factory and super-beam facility (the ISS). The accelerator facility described in section 2 incorporates the improvements that have been derived from the substantial amount of work carried out within the Accelerator Working Group. Highlights of these improvements include: (1) Initial concepts for the implementation of the proton driver at each of the three example sites, CERN, FNAL, and RAL; (2) Detailed studies of the energy deposition in the target area; (3) A reduction in the length of the muon beam phase-rotation and bunching systems; (4) Detailed analyses of the impact of the risk that stray magnetic field in the accelerating cavities in the ionization cooling channel will reduce the maximum operating gradient. Several alternative ionization-cooling lattices have been developed as fallback options to mitigate this technical risk; (5) Studies of particle loss in the muon front-end and the development of strategies to mitigate the deleterious effects of such losses; (6) The development of more complete designs for the muon linac and re-circulating linacs; (7) The development of a design for the muon FFAG that incorporates insertions for injection and extraction; and (8) Detailed studies of diagnostics in the decay ring. Other sub-systems have undergone a more 'incremental' evolution; an indication that the design of the Neutrino Factory has achieved a degree of maturity. The design of the neutrino detectors described in section 3 has been optimized and the Detector Working Group has made substantial improvements to the simulation and analysis of the Magnetized Iron Neutrino Detector (MIND) resulting in an improvement in the overall neutrino-detection efficiency and a reduction in the neutrino-energy threshold. In addition, initial consideration of the engineering of the MIND has

  10. Muon Colliders and Neutrino Factories

    Energy Technology Data Exchange (ETDEWEB)

    Kaplan, Daniel M. [IIT, Chicago

    2015-05-29

    Muon colliders and neutrino factories are attractive options for future facilities aimed at achieving the highest lepton-antilepton collision energies and precision measurements of Higgs boson and neutrino mixing matrix parameters. The facility performance and cost depend on how well a beam of muons can be cooled. Recent progress in muon cooling design studies and prototype tests nourishes the hope that such facilities could be built starting in the coming decade. The status of the key technologies and their various demonstration experiments is summarized. Prospects "post-P5" are also discussed.

  11. SRF for neutrino factories

    International Nuclear Information System (INIS)

    Padamsee, H.

    2003-01-01

    The Neutrino Factory calls for nearly 500 meters of 200 MHz SRF cavities to provide 7.5 GV. Such a facility is more demanding than the largest SRF installation to date, i.e., LEP-II, where 500 m of niobium-coated copper cavities provided more than 3 GV of acceleration. Based on the high real estate gradient desired to minimize muon loss, superconducting cavities are selected to provide active gradients of 15 - 17 MV/m, and a real estate gradient of 7.5 MV/m. At such high gradients, the peak RF power demand for copper cavities would become prohibitively expensive. By virtue of low losses, SC cavities can be filled slowly (rise time 3 ms) reducing the peak power demand to roughly half MW per cell. (author)

  12. Neutrino factory plans at CERN

    CERN Document Server

    Riche, J A

    2001-01-01

    The considerable interest raised by the discovery of neutrino oscillations and recent progress in studies of muon colliders has triggered interest in considering a neutrino factory at CERN. This paper explains the reference scenario, indicates the other possible choices and mentions the R&D that are foreseen.

  13. Review of U.S. Neutrino Factory Studies

    International Nuclear Information System (INIS)

    Zisman, Michael S.

    2005-01-01

    We summarize the status of the two U.S. feasibility studies carried out by the Neutrino Factory and Muon Collider Collaboration (NFMCC) along with recent improvements to Neutrino Factory design developed during the American Physical Society (APS) Neutrino Physics Study. Suggested accelerator topics for the International Scoping Study (ISS) are also indicated

  14. CrossRef Neutrino factories

    CERN Document Server

    Wildner, Elena

    2016-01-01

    Neutrinos are produced by many processes in our universe. These elusive particles reach the earth having a certain energy permitting them to react with nuclei in detectors that are specifically designed to probe their properties. However, to get higher intensities and higher energy neutrinos for better statistics and better physics reach, the use of accelerators is necessary to advance in the field of neutrino research. To produce neutrinos with an accelerator, one needs to send a high power beam onto a target to get particles or isotopes that produce neutrinos with the required properties, by decay. The parent particles have to be collected and prepared for injection into an accelerating structure. Accelerator-based experiments can tune the energy of the produced neutrinos by boosting and controlling the energy of the parent particle. The produced neutrinos will travel the distance between the source and the detector, generally through earth; the distance the neutrino travels through earth, the energy of the...

  15. Neutrino Factory Targets and the MICE Beam

    International Nuclear Information System (INIS)

    Walaron, Kenneth A.

    2007-01-01

    The future of particle physics in the next 20 years must include detailed study of neutrinos. The first proof of physics beyond the Standard Model of particle physics is evident in results from recent neutrino experiements which imply that neutrinos have mass and flavour mixing. The Neutrino Factory is the leading contender to measure precisely the neutrino mixing parameters to probe beyond the Standard Model physics.

  16. Muon front end for the neutrino factory

    Directory of Open Access Journals (Sweden)

    C. T. Rogers

    2013-04-01

    Full Text Available In the neutrino factory, muons are produced by firing high-energy protons onto a target to produce pions. The pions decay to muons and pass through a capture channel known as the muon front end, before acceleration to 12.6 GeV. The muon front end comprises a variable frequency rf system for longitudinal capture and an ionization cooling channel. In this paper we detail recent improvements in the design of the muon front end.

  17. Muon front end for the neutrino factory

    CERN Document Server

    Rogers, C T; Prior, G; Gilardoni, S; Neuffer, D; Snopok, P; Alekou, A; Pasternak, J

    2013-01-01

    In the neutrino factory, muons are produced by firing high-energy protons onto a target to produce pions. The pions decay to muons and pass through a capture channel known as the muon front end, before acceleration to 12.6 GeV. The muon front end comprises a variable frequency rf system for longitudinal capture and an ionization cooling channel. In this paper we detail recent improvements in the design of the muon front end.

  18. The Low-Energy Neutrino Factory

    International Nuclear Information System (INIS)

    Brass, Alan; Geer, Steve; Ellis, Malcolm; Mena, Olga; Pascoli, Silvia

    2008-01-01

    To date most studies of Neutrino Factories have focused on facilities where the energy of the muon in the storage ring has been in the range of 25-50 GeV. In this paper we present a concept for a Low-Energy (∼ 4 GeV) neutrino factory. For baselines of O(1000 km), the rich oscillation pattern at low neutrino interaction energy (0.5 - ∼3 GeV) provides the unique performance of this facility with regard to its sensitivity to CP violation and the determination of the neutrino mass hierarchy. A unique neutrino detector is needed, however, in order to exploit this oscillation pattern. We will describe the basic accelerator facility, demonstrate the methodology of the analysis and give an estimate on how well the Low-Energy neutrino factory can measure θ 13 , CP violation and the mass hierarchy. We will also describe the detector concept that is used, show a preliminary analysis regarding its performance and indicate what R and D is still needed. Finally we will show how the Low-Energy neutrino factory could be a step towards an energy frontier muon collider.

  19. Neutrinos: from the Workshop to the Factory

    CERN Multimedia

    2001-01-01

    Over the next 5 years much work will be done to reach a theoretical and practical description of a neutrino factory. How could this project turn out to be an interesting future option for CERN? Neutrino beams travelling from CERN to the Canary Islands? And to the Svalbard archipelago in Norway? Or even to the Pyhaesalmi Mine in Finland? Why neutrinos? And why so far? The answers provide one of CERN's next challenging options: the construction of a high-energy muon storage ring to provide neutrino beams. This project, nicknamed 'neutrino factory', now figures in CERN's middle term plan as a recognized and supported research and development project. International collaborations, with other European laboratories and also with America and Japan, are now being set up. Long baseline locations for neutrino oscillations studies at a CERN based neutrino factory. Early in its history, LEP established that there exist just three kinds of light neutrinos, those associated with the electron, muon, and tau leptons. For a...

  20. Tests of CPT invariance at neutrino factories

    International Nuclear Information System (INIS)

    Bilenky, Samoil M.; Freund, Martin; Lindner, Manfred; Ohlsson, Tommy; Winter, Walter

    2002-01-01

    We investigate possible tests of CPT invariance on the level of event rates at neutrino factories. We do not assume any specific model but phenomenological differences in the neutrino-antineutrino masses and mixing angles in a Lorentz invariance preserving context, such as could be induced by physics beyond the standard model. We especially focus on the muon neutrino and antineutrino disappearance channels in order to obtain constraints on the neutrino-antineutrino mass and mixing angle differences; we found, for example, that the sensitivity |m 3 -m(bar sign) 3 |(less-or-similar sign)1.9x10 -4 eV could be achieved

  1. Phenomenology of neutrino oscillations at the neutrino factory

    International Nuclear Information System (INIS)

    Tang, Jian

    2011-01-01

    We consider the prospects for a neutrino factory measuring mixing angles, the CP violating phase and mass-squared differences by detecting wrong-charge muons arising from the chain μ + → ν e → ν μ → μ - and the right-charge muons coming from the chain μ + → anti ν μ → anti ν μ → μ - (similar to μ - chains), where ν e → ν μ and anti ν μ → anti ν μ are neutrino oscillation channels through a long baseline. First, we study physics with near detectors and consider the treatment of systematic errors including cross section errors, flux errors, and background uncertainties. We illustrate for which measurements near detectors are required, discuss how many are needed, and what the role of the flux monitoring is. We demonstrate that near detectors are mandatory for the leading atmospheric parameter measurements if the neutrino factory has only one baseline, whereas systematic errors partially cancel if the neutrino factory complex includes the magic baseline. Second, we perform the baseline and energy optimization of the neutrino factory including the latest simulation results from the magnetized iron neutrino detector (MIND). We also consider the impact of τ decays, generated by appearance channels ν μ → ν τ and ν e → ν τ , on the discovery reaches of the mass orderings, the leptonic CP violation, and the non-zero θ 13 , which we find to be negligible for the considered detector. Third, we make a comparison of a high energy neutrino factory to a low energy neutrino factory and find that they are just two versions of the same experiment optimized for different regions of the parameter space. In addition, we briefly comment on whether it is useful to build the bi-magic baseline at the low energy neutrino factory. Finally, the effects of one additional massive sterile neutrino are discussed in the context of a combined short and long baseline setup. It is found that near detectors can provide the required sensitivity at the

  2. Phenomenology of neutrino oscillations at the neutrino factory

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Jian

    2011-12-19

    We consider the prospects for a neutrino factory measuring mixing angles, the CP violating phase and mass-squared differences by detecting wrong-charge muons arising from the chain {mu}{sup +} {yields} {nu}{sub e} {yields} {nu}{sub {mu}} {yields} {mu}{sup -} and the right-charge muons coming from the chain {mu}{sup +} {yields} anti {nu}{sub {mu}} {yields} anti {nu}{sub {mu}} {yields} {mu}{sup -} (similar to {mu}{sup -} chains), where {nu}{sub e} {yields} {nu}{sub {mu}} and anti {nu}{sub {mu}} {yields} anti {nu}{sub {mu}} are neutrino oscillation channels through a long baseline. First, we study physics with near detectors and consider the treatment of systematic errors including cross section errors, flux errors, and background uncertainties. We illustrate for which measurements near detectors are required, discuss how many are needed, and what the role of the flux monitoring is. We demonstrate that near detectors are mandatory for the leading atmospheric parameter measurements if the neutrino factory has only one baseline, whereas systematic errors partially cancel if the neutrino factory complex includes the magic baseline. Second, we perform the baseline and energy optimization of the neutrino factory including the latest simulation results from the magnetized iron neutrino detector (MIND). We also consider the impact of {tau} decays, generated by appearance channels {nu}{sub {mu}} {yields} {nu}{sub {tau}} and {nu}{sub e} {yields} {nu}{sub {tau}}, on the discovery reaches of the mass orderings, the leptonic CP violation, and the non-zero {theta}{sub 13}, which we find to be negligible for the considered detector. Third, we make a comparison of a high energy neutrino factory to a low energy neutrino factory and find that they are just two versions of the same experiment optimized for different regions of the parameter space. In addition, we briefly comment on whether it is useful to build the bi-magic baseline at the low energy neutrino factory. Finally, the

  3. A large magnetic detector for the neutrino factory

    International Nuclear Information System (INIS)

    Cervera, A.; Dydak, F.; Gomez Cadenas, J.J.

    2000-01-01

    The physics opportunities of the neutrino factory have been the subject of a number of recent studies. It was shown that sensitive measurements of the angle θ 13 , of MSW effects, and of the sign of the atmospheric mass difference Δm 23 2 are possible, and even CP violation in the neutrino mixing matrix may be within reach. The focus of interest is the oscillation ν e →ν μ , which leads in the well-defined neutrino beam of the neutrino factory to 'wrong-sign' muon events. In this paper, we show that a large magnetic detector will be capable of detecting with high efficiency and small backgrounds such wrong-sign muon events. We present a conceptual design of the apparatus and its performance. Various backgrounds are analysed and we demonstrate that they can be sufficiently suppressed by appropriate cuts. We illustrate the performance of the large magnetic detector by its sensitivity to the angle θ 13

  4. Sterile neutrinos beyond LSND at the neutrino factory

    International Nuclear Information System (INIS)

    Meloni, Davide; Tang Jian; Winter, Walter

    2010-01-01

    We discuss the effects of one additional sterile neutrino at the Neutrino Factory. Compared to earlier analyses, which have been motivated by Liquid Scintillator Neutrino Detector (LSND) results, we do not impose any constraint on the additional mass squared splitting. This means that the additional mass eigenstate could, with small mixings, be located among the known ones, as it is suggested by the recent analysis of cosmological data. We use a self-consistent framework at the Neutrino Factory without any constraints on the new parameters. We demonstrate for a combined short and long baseline setup that near detectors can provide the expected sensitivity at the LSND-motivated Δm 41 2 -range, while some sensitivity can also be obtained in the region of the atmospheric mass splitting from the long baselines. We point out that limits on such very light sterile neutrinos may also be obtained from a reanalysis of atmospheric and solar neutrino oscillation data, as well as from supernova neutrino observations. In the second part of the analysis, we compare our sensitivity with the existing literature using additional assumptions, such as |Δm 41 2 |>>|Δm 31 2 |, leading to averaging of the fast oscillations in the far detectors. We demonstrate that while the Neutrino Factory has excellent sensitivity compared to existing studies using similar assumptions, one has to be very careful interpreting these results for a combined short and long baseline setup where oscillations could occur in the near detectors. We also test the impact of additional ν τ detectors at the short and long baselines, and we do not find a substantial improvement of the sensitivities.

  5. Muon Acceleration: Neutrino Factory and Beyond

    Energy Technology Data Exchange (ETDEWEB)

    Bogacz, Alex [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2018-03-01

    We summarize the current state of a concept for muon acceleration aimed at a future Neutrino Factory and extendable to Higgs Factory. The main thrust of these studies was to reduce the overall cost while maintaining performance by exploring the interplay between the complexity of the cooling systems and the acceptance of the accelerator complex. To ensure adequate survival for the short-lived muons, acceleration must occur at high average gradient. The need for large transverse and longitudinal acceptances drives the design of the acceleration system to an initially low RF frequency, e.g., 325 MHz, which is then increased to 650 MHz as the transverse size shrinks with increasing energy. High-gradient normal conducting RF cavities at these frequencies require extremely high peak-power RF sources. Hence superconducting RF (SRF) cavities are chosen. We consider an SRF-efficient design based on a multi-pass (4.5) ?dogbone? RLA, extendable to multi-pass FFAG-like arcs.

  6. Neutrino Factory and Muon Collider Collaboration R and D Program

    International Nuclear Information System (INIS)

    Zisman, M.S.

    2000-01-01

    The Neutrino Factory and Muon Collider Collaboration (MC) comprises some 140 scientists and engineers located at U.S. National Laboratories and Universities, and at a number of non-U.S. research institutions. In the past year, the MC R and D program has shifted its focus mainly toward the design issues related to the development of a Neutrino Factory based on a muon storage ring. In this paper the status of the various R and D activities is described, and future plans are outlined

  7. Golden measurements at a neutrino factory

    International Nuclear Information System (INIS)

    Cervera, A.; Donini, A.; Gavela, M.B.; Gomez Cadenas, J.J.; Hernandez, P.; Mena, O.; Rigolin, S.

    2000-01-01

    The precision and discovery potential of a neutrino factory based on muon storage rings is studied. For three-family neutrino oscillations, we analyse how to measure or severely constraint the angle θ 13 , CP-violation, MSW effects and the sign of the atmospheric mass difference Δm 2 23 . We present a simple analytical formula for the oscillation probabilities in matter, with all neutrino mass differences non-vanishing, which clarifies the subtleties involved in disentangling the unknown parameters. The appearance of 'wrong-sign muons' at three reference baselines is considered: 732 km, 3500 km, and 7332 km. We exploit the dependence of the signal on the neutrino energy, and include as well realistic background estimations and detection efficiencies. The optimal baseline turns out to be O (3000 km). Analyses combining the information from different baselines are also presented

  8. R and D Toward Neutrino Factories and Muon Colliders

    International Nuclear Information System (INIS)

    Zisman, Michael S.

    2003-01-01

    R and D aimed at the production, acceleration, and storage of intense muon beams is under way in the U.S., in Europe, and in Japan. Considerable progress has been made in the past few years toward the design of a ''Neutrino Factory'' in which a beam of 20-50 GeV mu- or mu+ is stored. Decay neutrinos from the beam illuminate a detector located roughly 3000 km from the ring. Here, we briefly describe the ingredients of a Neutrino Factory and then discuss the current R and D program and its results. A key concept in the design is ''ionization cooling,'' a process whereby the muon emittance is reduced by repeated interactions with an absorber material followed by reacceleration with high-gradient rf cavities. Plans to test this concept in the Muon Ionization Cooling Experiment (MICE) are well along and are described briefly

  9. Intense muon beams and neutrino factories

    International Nuclear Information System (INIS)

    Parsa, Z.

    2000-01-01

    High intensity muon sources are needed in exploring neutrino factories, lepton flavor violating muon processes, and lower energy experiments as the stepping phase towards building higher energy μ + μ - colliders. We present a brief overview, sketch of a neutrino source, and an example of a muon storage ring at BNL with detector(s) at Fermilab, Sudan, etc. Physics with low energy neutrino beams based on muon storage rings (μSR) and conventional Horn Facilities are described and compared. CP violation Asymmetries and a new Statistical Figure of Merit to be used for comparison is given. Improvements in the sensitivity of low energy experiments to study Flavor changing neutral currents are also included

  10. Golden measurements at a neutrino factory

    CERN Document Server

    Cervera-Villanueva, Anselmo; Gavela-Legazpi, Maria Belen; Cadenas, J J G; Hernández, Pilar; Mena, O; Rigolin, Stefano

    2000-01-01

    The precision and discovery potential of a neutrino factory based on muonstorage rings is studied. For three-family neutrino oscillations, we analysehow to measure or severely constraint the angle $\\theta_{13}$, CP violation,MSW effects and the sign of the atmospheric mass difference $\\Delta m^2_{23}$.We present a simple analytical formula for the oscillation probabilities inmatter, with all neutrino mass differences non-vanishing, which clarifies thesubtleties involved in disentangling the unknown parameters. The appearance of``wrong-sign muons'' at three reference baselines is considered: 732 km, 3500km, and 7332 km. We exploit the dependence of the signal on the neutrinoenergy, and include as well realistic background estimations and detectionefficiencies. The optimal baseline turns out to be ${\\cal O}(3000$ km).Analyses combining the information from different baselines are also presented.

  11. Measurement of CP violation at a Neutrino Factory

    CERN Document Server

    Gómez-Cadenas, J J

    2001-01-01

    The prospects of measuring CP violation in the leptonic sector using the intense neutrino beams arising from muon decay in the straight sections of a muon accumulator ring (the so-called neutrino factory) are discussed.

  12. 17th International Workshop on Neutrino Factories and Future Neutrino Facilities Search

    CERN Document Server

    2015-01-01

    NuFact15 is the seventeenth in a series that started in 1999 as an important yearly workshop with emphasis on future neutrino projects. This will be the first edition in Latin America, showing the scientific growth of this field. The main goals of the workshop are to review the progress on studies of future facilities able to improve on measurements of the properties of neutrinos and charged lepton flavor violation as well as new phenomena searches beyond the capabilities of presently planned experiments. Since such progress in the neutrino sector could require innovation in neutrino beams, the role of a neutrino factory within future HEP initiatives will be addressed. The workshops are not only international but also interdisciplinary in that experimenters, theorists and accelerator physicists from the Asian, American and European regions share expertise with the common goal of designing the next generation of experiments.

  13. The physics case of the Neutrino Factory

    Energy Technology Data Exchange (ETDEWEB)

    Gomez-Cadenas, J J [IFIC, CSIC-UV, Valencia (Spain)], E-mail: gomez@ific.uv.es

    2008-11-01

    I discuss the physics case of the standard Neutrino Factory facility coupled to an iron detector to exploit the so-called 'Golden-Channel'. The performance of the facility is impressive, although it is not free from degeneracies arising from a combination of physics and instrumental limitations. Nevertheless, one could explore at great depth the parameter of the leptonic mixing matrix as well as the mass hierarchy. Best performance is obtained with two baselines (one of them very long) and an improved magnetic detector with low energy detection threshold.

  14. Accelerator and Technical Sector Seminar: Future neutrino facilities: the neutrino factory

    CERN Multimedia

    2012-01-01

    Thursday 19.January 2012 at 14:15  -  IT Auditorium (bldg. 31 3-004) Future neutrino facilities: the neutrino factory by Gersende Prior / University of Geneva and CERN EN/MEF The neutrino factory is one of the proposed designs for a future intense neutrino beam facility. In its current layout, a high-power proton beam impinges on an Hg jet target producing pions, decaying in turn into muons. In order to reduce the particle beam emittance, the muon transverse momentum is reduced through ionization cooling by a technically demanding set-up made of closely-packed RF cavities alternating with absorbers. In this talk I will present the motivation for building an intense neutrino beam and some of the proposed neutrino facilities' design. I will discuss the challenges inherent to the cooling of muons, possible optimization of the current baseline and the on-going R&D. ________________ ATS Seminars Organisers: H. Burkhardt (BE), S. Sgobba (EN), G. deRijk (TE)

  15. Status of neutrino factory and muon collider R and D

    International Nuclear Information System (INIS)

    Zisman, M.S.

    2001-01-01

    A significant worldwide R and D effort is presently directed toward solving the technical challenges of producing, cooling, accelerating, storing, and eventually colliding beams of muons. Its primary thrust is toward issues critical to a Neutrino Factory, for which R and D efforts are under way in the U.S., via the Neutrino Factory and Muon Collider Collaboration (MC); in Europe, centered at CERN; and in Japan, at KEK. Under study and experimental development are production targets handling intense proton beams (1-4 MW), phase rotation systems to reduce beam energy spread, cooling channels to reduce transverse beam emittance for the acceleration system, and storage rings where muon decays in a long straight section provide a neutrino beam for a long-baseline (3000 km) experiment. Critical experimental activities include development of very high gradient normal conducting RF (NCRF) and superconducting RF (SCRF) cavities, high-power liquid-hydrogen absorbers, and high-field superconducting solenoids. Components and instrumentation that tolerate the intense decay products of the muon beam are being developed for testing. For a high-luminosity collider, muons must be cooled longitudinally as well as transversely, requiring an emittance exchange scheme. In addition to the experimental R and D effort, sophisticated theoretical and simulation tools are needed for the design. Here, the goals, present status, and future R and D plans in these areas will be described

  16. The neutrino factory beam and experiments

    CERN Document Server

    Blondel, A; Campanelli, M; Cervera-Villanueva, Anselmo; Cline, David B; Collot, J; De Jong, M; Donini, Andrea; Dydak, Friedrich; Edgecock, R; Gavela-Legazpi, Maria Belen; Gómez-Cadenas, J J; González-Garciá, M Concepción; Gruber, P M; Harris, D A; Hernández, Pilar; Kuno, Y; Litchfield, P J; McFarland, K; Mena, O; Migliozzi, P; Palladino, Vittorio; Panman, J; Papadopoulos, I M; Para, A; Peña-Garay, C; Pérez, P; Rigolin, Stefano; Romanino, Andrea; Rubbia, André; Strolin, P; Wojcicki, S G

    2000-01-01

    The discovery of neutrino oscillations marks a major milestone in the history of neutrino physics, and opens a new window to the still mysterious origin of masses and flavour-mixing. Many current and forthcoming experiments will answer open questions; however, a major step forward, up to and possibly including CP violation in the neutrino-mixing matrix, requires the neutrino beams from a \

  17. Neutrino Factory Accelerator R and D: Status and Priorities

    International Nuclear Information System (INIS)

    Zisman, Michael S.

    2005-01-01

    This paper summarizes the status of worldwide Neutrino Factory R and D efforts. Activities are categorized as simulations, component development, and system tests. An indication of R and D tasks that remain to be accomplished is also given

  18. Optimising the Target and Capture Sections of the Neutrino Factory

    CERN Document Server

    Hansen, Ole Martin; Stapnes, Steinar

    The Neutrino Factory is designed to produce an intense high energy neutrino beam from stored muons. The majority of the muons are obtained from the decay of pions, produced by a proton beam impinging on a free-flowing mercury-jet target and captured by a high magnetic field. It is important to capture a large fraction of the produced pions to maximize the intensity of the neutrino beam. Various optimisation studies have been performed with the aim of maximising the muon influx to the accelerator and thus the neutrino beam intensity. The optimisation studies were performed with the use of Monte Carlo simulation tools. The production of secondary particles, by interactions between the incoming proton beam and the mercury target, was optimised by varying the proton beam impact position and impact angles on the target. The proton beam and target interaction region was studied and showed to be off the central axis of the capture section in the baseline configuration. The off-centred interaction region resulted in ...

  19. Hadron Production for the Neutrino Factory and for the Atmospheric Neutrino Flux

    CERN Document Server

    2002-01-01

    The HARP experiment carries out, at the CERN PS, a programme of measurements of secondary hadron production, over the full solid angle, produced on thin and thick nuclear targets by beams of protons and pions with momenta in the range 2 to 15~\\GeVc. The first aim of this experiment is to acquire adequate knowledge of pion yields for an optimal design of the proton driver of the Neutrino Factory. The second aim is to reduce substantially the existing $\\sim 30$\\% uncertainty in the calculation of absolute atmospheric neutrino fluxes and the $\\sim 7$\\% uncertainty in the ratio of neutrino flavours, required for a refined interpretation of the evidence for neutrino oscillation from the study of atmospheric neutrinos in present and forthcoming experiments. The HARP experiment comprises a large-acceptance charged-particle magnetic spectrometer of conventional design, located in the East Hall of the CERN PS and using the T9 tagged charged-particle beam. The main detector is a cylindrical TPC inside a solenoid magnet...

  20. Neutrino factory and muon collider collaboration R and D activities

    International Nuclear Information System (INIS)

    Zisman, Michael S.; Neutrino Factory and Muon Collider Collaborat

    2001-01-01

    The Neutrino Factory and Muon Collider Collaboration (MC) comprises about 140 U.S. and non-U.S. accelerator and particle physicists. The MC is carrying out an R and D program aimed at validating the critical design concepts required for the construction of such machines. We are committed to encouraging international cooperation and coordination of the R and D effort. Main activities of the MC include a Targetry program, a MUCOOL program, a component development program, and a theory and simulation effort. Moreover, the MC has participated in several feasibility studies for a complete Neutrino Factory facility, with the aim of identifying any additional R and D activities needed to prepare a Zeroth-order Design Report (ZDR) in about two years and a Conceptual Design report (CDR) about two years thereafter. In this paper, the R and D goals in each area will be indicated, and the present status and future plans of the R and D program will be described

  1. Oscillation Physics with a Neutrino Factory

    CERN Document Server

    Apollonio, M.; Broncano, A.; Bonesini, M.; Bouchez, J.; Bueno, A.; Burguet-Castell, J.; Casper, D.; Catanesi, G.; Cervera, A.; Cooper, S.; Donega, M.; Donini, A.; de Gouvea, A.; de Min, A.; Edgecock, R.; Ellis, J.; Fechner, M.; Fernandez, E.; Ferri, F.; Gavela, B.; Giannini, G.; Gibin, D.; Gilardoni, S.; Gomez-Cadenas, J.J.; Gruber, P.; Guglielmi, A.; Hernandez, P.; Huber, P.; Laveder, M.; Lindner, M.; Meloni, D.; Mena, O.; Menghetti, H.; Mezzetto, M.; Migliozzi, P.; Navas-Concha, S.; Palladino, V.; Papadopoulos, I.; Peach, K.; Radicioni, E.; Ragazzi, S.; Rigolin, S.; Romanino, A.; Rico, J.; Rubbia, A.; Santin, G.; Sartorelli, G.; Selvi, M.; Spiro, M.; Tabarelli, T.; Tonazzo, A.; Velasco, M.; Volkov, G.; Winter, W.; Zucchelli, P.

    2004-01-01

    A generation of neutrino experiments have established that neutrinos mix and probably have mass. The mixing phenomenon points to processes beyond those of the Standard Model, possibly at the Grand Unification energy scale. A extensive sequence of of experiments will be required to measure precisely all the parameters of the neutrino mixing matrix, culminating with the discovery and study of leptonic CP violation. As a first step, extensions of conventional pion/kaon decay beams, such as off-axis beams or low-energy super-beams, have been considered. These could yield first observations of $\

  2. Optimized Neutrino Factory for small and large θ13

    International Nuclear Information System (INIS)

    Agarwalla, Sanjib Kumar

    2013-01-01

    Recent results from long baseline neutrino oscillation experiments point towards a non-zero value of θ 13 at around 3σ confidence level. In the coming years, further ratification of this result with high significance will have crucial impact on the planning of the future long baseline Neutrino Factory setup aimed to explore leptonic CP violation and the neutrino mass ordering. In this talk, we discuss the baseline and energy optimization of the Neutrino Factory including the latest simulation results on the magnetized iron neutrino detector (MIND) in the light of both small and large θ 13 . We find that in case of small θ 13 , baselines of about 2500 to 5000 km is the optimal choice for the CP violation measurement with E μ as low as 12 GeV can be considered. However, for large θ 13 , we show that the lower threshold and the backgrounds reconstructed at lower energies allow in fact for muon energies as low as 5 to 8 GeV at considerably shorter baselines, such as Fermilab to Homestake. This suggests that with the latest MIND simulation, low- and high-energy versions of the Neutrino Factory are just two different forms of the same experiment optimized for different regions of the parameter space.

  3. R and D Toward a Neutrino Factory and Muon Collider

    International Nuclear Information System (INIS)

    Zisman, Michael S.

    2011-01-01

    Significant progress has been made in recent years in R and D towards a neutrino factory and muon collider. The U.S. Muon Accelerator Program (MAP) has been formed recently to expedite the R and D efforts. This paper will review the U.S. MAP R and D programs for a neutrino factory and muon collider. Muon ionization cooling research is the key element of the program. The first muon ionization cooling demonstration experiment, MICE (Muon Ionization Cooling Experiment), is under construction now at RAL (Rutherford Appleton Laboratory) in the UK. The current status of MICE will be described.

  4. Review of North American Neutrino Factory R and D

    International Nuclear Information System (INIS)

    Zisman, Michael S.; Neutrino Factory and Muon Collider Collaboration

    2002-01-01

    We report here on the R and D program of the U.S. Neutrino Factory and Muon Collider Collaboration. Our effort includes work on targetry, muon ionization cooling, simulation work, and development of superconducting RF cavities. In addition, we are involved in the international effort toward a Muon Ionization Cooling Experiment (MICE). Recent activities in all these areas will be described

  5. Neutrino Factory R and D in the U.S

    International Nuclear Information System (INIS)

    Zisman, Michael S.

    2003-01-01

    We report here on the technical progress and R andD plans of the U.S. Neutrino Factory and Muon Collider Collaboration. Programs in targetry, cooling, acceleration, and simulations are covered. U.S. activities in support of the international Muon Ionization Cooling Experiment (MICE) are also described

  6. Muon physics possibilities at a muon-neutrino factory

    NARCIS (Netherlands)

    Jungmann, KP

    2001-01-01

    New intense proton accelerators with above GeV energies and MW beam power, such as they are discussed in connection with neutrino factories, appear to be excellently suited for feeding bright muon sources for low-energy muon science. Muon rates with several orders of magnitude increased flux

  7. R and D Toward a Neutrino Factory and Muon Collider

    International Nuclear Information System (INIS)

    Zisman, Michael S.

    2009-01-01

    There is considerable interest in the use of muon beams to create either an intense source of decay neutrinos aimed at a detector located 3000-7500 km away (a Neutrino Factory), or a Muon Collider that produces high-luminosity collisions at the energy frontier. R and D aimed at producing these facilities has been under way for more than 10 years. This paper will review experimental results from MuCool, MERIT, and MICE and indicate the extent to which they will provide proof-of-principle demonstrations of the key technologies required for a Neutrino Factory or Muon Collider. Progress in constructing components for the MICE experiment will also be described.

  8. Numerical study of a magnetically insulated front-end channel for a neutrino factory

    Directory of Open Access Journals (Sweden)

    Diktys Stratakis

    2011-01-01

    Full Text Available A neutrino factory, which can deliver an intense flux of ∼10^{21} neutrinos per year from a multi-GeV stored muon beam, is seemingly the ideal tool for studying neutrino oscillations and CP violations for leptons. The front end of this facility plays a critical role in determining the number of muons that can be accepted by the downstream accelerators. Delivering peak performance requires transporting the muon beams through long sections of a beam channel containing high-gradient rf cavities and strong focusing solenoids. Here, we propose a novel scheme to improve the performance of the cavities, thereby increasing the number of muons within the acceptance of the accelerator chain. The key element of our new scheme is to apply a tangential magnetic field to the rf surfaces, thus forcing any field-emitted electrons to return to the surface before gaining enough energy to damage the cavity. We incorporate this idea into a new lattice design for a neutrino factory, and detail its performance numerically. Although our proposed front-end channel requires more rf power than conventional pillbox designs, it provides enough beam cooling and muon production to be a feasible option for a neutrino factory.

  9. The NuMAX Long Baseline Neutrino Factory Concept

    Energy Technology Data Exchange (ETDEWEB)

    Delahaye, J-P. [SLAC; Ankenbrandt, C. [MUONS Inc., Batavia; Bogacz, A. [Jefferson Lab; Huber, P. [Virginia Tech.; Kirk, H. [Brookhaven; Neuffer, D. [Fermilab; Palmer, M. A. [Fermilab; Ryne, R. [LBL, Berkeley; Snopok, P. [IIT, Chicago

    2018-03-19

    A Neutrino Factory where neutrinos of all species are produced in equal quantities by muon decay is described as a facility at the intensity frontier for exquisite precision providing ideal conditions for ultimate neutrino studies and the ideal complement to Long Baseline Facilities like LBNF at Fermilab. It is foreseen to be built in stages with progressively increasing complexity and performance, taking advantage of existing or proposed facilities at an existing laboratory like Fermilab. A tentative layout based on a recirculating linac providing opportunities for considerable saving is discussed as well as its possible evolution toward a muon collider if and when requested by Physics. Tentative parameters of the various stages are presented as well as the necessary R&D to address the technological issues and demonstrate their feasibility.

  10. Leptonic CP Violation measurement at the neutrino factory

    International Nuclear Information System (INIS)

    Burguet Castell, J.; Mena, O.

    2003-01-01

    In this talk, based on the work [J. Burguet Castell, et al., Nucl. Phys. B 608 (2001) 301], we refine our previous analysis [A. Cervera, et al., Nucl. Phys. B 579 (2000) 17] of the sensitivity to leptonic CP violation and θ 13 at a neutrino factory in the LMA-MSW scenario, by exploring the full range of these two parameters. We have discovered that there exist, at fixed neutrino energy, E ν , and baseline, L, degenerate solutions. Although the spectral analysis helps in disentangling fake from true solutions, a leftover product of this degeneracy remains for a realistic detector, which we analyse. Furthermore, we take into account the expected uncertainties on the solar and atmospheric oscillation parameters and in the average Earth matter density along the neutrino path. An intermediate baseline of O(3000) km is still the best option to tackle CP violation, although a combination of two baselines turns out to be very important in resolving degeneracies

  11. Recent progress in neutrino factory and muon collider research within the Muon Collaboration

    Directory of Open Access Journals (Sweden)

    Mohammad M. Alsharo’a

    2003-08-01

    Full Text Available We describe the status of our effort to realize a first neutrino factory and the progress made in understanding the problems associated with the collection and cooling of muons towards that end. We summarize the physics that can be done with neutrino factories as well as with intense cold beams of muons. The physics potential of muon colliders is reviewed, both as Higgs factories and compact high-energy lepton colliders. The status and time scale of our research and development effort is reviewed as well as the latest designs in cooling channels including the promise of ring coolers in achieving longitudinal and transverse cooling simultaneously. We detail the efforts being made to mount an international cooling experiment to demonstrate the ionization cooling of muons.

  12. Recent progress in neutrino factory and muon collider research within the muon collaboration

    International Nuclear Information System (INIS)

    Alsharo'a, Mohammad M.; Ankenbrandt, Charles M.; Atac, Muzaffer; Autin, Bruno R.; Balbekov, Valeri I.; Barger, Vernon D.; Benary, Odette; Bennett, J. Roger J.; Berger, Michael S.; Berg, J. Scott; Berz, Martin; Black, Edgar L.; Blondel, Alain; Bogacz, S. Alex; Bonesini, M.; Bracker, Stephen B.; Bross, Alan D.; Bruno, Luca; Buckley-Geer, Elizabeth J.; Caldwell, Allen C.; Companelli, Mario; Cassel, Kevin W.; Catanesi, M. Gabriela; Chattopadhyay, Swapan; Chou, Weiren; Cline, David B.; Coney, Linda R.; Conrad, Janet M.; Corlett, John N.; Cremaldi, Lucien; Cummings, Mary Anne; Darve, Christine; DeJongh, Fritz; Drozhdin, Alexandr; Drumm, Paul; Elvira, V. Daniel; Errede, Deborah; Fabich, Adrian; Fawley, William M.; Fernow, Richard C.; Ferrario, Massimo; Finley, David A.; Fisch, Nathaniel J.; Fukui, Yasuo; Furman, Miguel A.; Gabriel, Tony A.; Galea, Raphael; Gallardo, Juan C.; Garoby, Roland; Garren, Alper A.; Geer, Stephen H.; Gilardoni, Simone; Van Ginneken, Andreas J.; Ginzburg, Ilya F.; Godang, Romulus; Goodman, Maury; Gosz, Michael R.; Green, Michael A.; Gruber, Peter; Gunion, John F.; Gupta, Ramesh; Haines, John R.; Hanke, Klaus; Hanson, Gail G.; Han, Tao; Haney, Michael; Hartill, Don; Hartline, Robert E.; Haseroth, Helmut D.; Hassanein, Ahmed; Hoffman, Kara; Holtkamp, Norbert; Holzer, E. Barbara; Johnson, Colin; Johnson, Rolland P.; Johnstone, Carol; Jungmann, Klaus; Kahn, Stephen A.; Kaplan, Daniel M.; Keil, Eberhard K.; Kim, Eun-San; Kim, Kwang-Je; King, Bruce J.; Kirk, Harold G.; Kuno, Yoshitaka; Ladran, Tony S.; Lau, Wing W.; Learned, John G.; Lebedev, Valeri; Lebrun, Paul; Lee, Kevin; Lettry, Jacques A.; Lavender, Marco; Li, Derun; Lombardi, Alessandra; Lu, Changguo; Makino, Kyoko; Malkin, Vladimir; Marfatia, D.; McDonald, Kirk T.; Mezzetto, Mauro; Miller, John R.; Mills, Frederick E.; Mocioiu, I.; Mokhov, Nikolai V.; Monroe, Jocelyn; Moretti, Aldred; Mori, Yoshiharu; Neuffer, David V.; Ng, King-Yuen; Norem, James H.

    2003-01-01

    We describe the status of our effort to realize a first neutrino factory and the progress made in understanding the problems associated with the collection and cooling of muons towards that end. We summarize the physics that can be done with neutrino factories as well as with intense cold beams of muons. The physics potential of muon colliders is reviewed, both as Higgs Factories and compact high energy lepton colliders. The status and timescale of our research and development effort is reviewed as well as the latest designs in cooling channels including the promise of ring coolers in achieving longitudinal and transverse cooling simultaneously. We detail the efforts being made to mount an international cooling experiment to demonstrate the ionization cooling of muons

  13. A Possible Hybrid Cooling Channel for a Neutrino Factory

    International Nuclear Information System (INIS)

    Zisman, Michael S.; Gallardo, Juan C.

    2010-01-01

    A Neutrino Factory requires an intense and well-cooled (in transverse phase space) muon beam. We discuss a hybrid approach for a linear 4D cooling channel consisting of high-pressure gas-filled RF cavities--potentially allowing high gradients without breakdown--and discrete LiH absorbers to provide the necessary energy loss that results in the required muon beam cooling. We report simulations of the channel performance and its comparison with the vacuum case; we also briefly discuss technical and safety issues associated with cavities filled with high-pressure hydrogen gas. Even with additional windows that might be needed for safety reasons, the channel performance is comparable to that of the original, all-vacuum Feasibility Study 2a channel on which our design is based. If tests demonstrate that the gas-filled RF cavities can operate effectively with an intense beam of ionizing particles passing through them, our approach would be an attractive way of avoiding possible breakdown problems with a vacuum RF channel.

  14. E1 Working Group summary: Neutrino factories and muon colliders Neutrino Factories and Muon Colliders

    CERN Document Server

    Adams, T.; Balbekov, V.; Barenboim, G.; Harris, Deborah A.; Chou, W.; DeJongh, F.; Geer, S.; Johnstone, C.; Mokhov, N.; Morfin, J.; Neuffer, D.; Raja, R.; Romanino, A.; Shanahan, P.; Spentzouris, P.; Yu, J.; Barger, V.; Marfatia, D.; Han, Tao; Aoki, M.; Kuno, Y.; Sato, A.; Ichikawa, K.; Nakaya, T.; Machida, S.; Nagamine, K.; Yoshimura, K.; Ball, R.D.; Campanelli, Mario; Casper, D.; Molzon, W.; sobel, H.; Cline, D.B.; Cushman, P.; Diwan, M.; Kahn, S.; Morse, W.; Palmer, R.; Parsa, Zohreh; Roser, T.; Fleming, Bonnie T.; Formaggio, J.A.; Garren, A.; Gavela, M.B.; Gonzalez-Garcia, M.C.; Hanson, G.; Berger, M.; Kayser, Boris; Jung, C.K.; Shrock, R.; McGrew, C.; Mocioiu, I.; Lindner, M.; McDonald, K.; McFarland, Kevin Scott; Nienaber, P.; Olness, F.; Pope, B.; Rigolin, S.; Roberts, L.; Schellman, H.; Shiozawa, M.; Wai, L.; Wang, Y.F.; Whisnant, K.; Zeller, M.

    2001-01-01

    We are in the middle of a time of exciting discovery, namely that neutrinos have mass and oscillate. In order to take the next steps to understand this potential window onto what well might be the mechanism that links the quarks and leptons, we need both new neutrino beams and new detectors. The new beamlines can and should also provide new laboratories for doing charged lepton flavor physics, and the new detectors can and should also provide laboratories for doing other physics like proton decay, supernovae searches, etc. The new neutrino beams serve as milestones along the way to a muon collider, which can answer questions in yet another sector of particle physics, namely the Higgs sector or ultimately the energy frontier. In this report we discuss the current status of neutrino oscillation physics, what other oscillation measurements are needed to fully explore the phenomenon, and finally, what other new physics can be explored as a result of building of these facilities.

  15. Alternative Muon Cooling Options based on Particle-Matter-Interaction for a Neutrino Factory

    CERN Document Server

    Stratakis, D; Alekou, A; Pasternak, J

    2013-01-01

    An ionization cooling channel is a tightly spaced lattice containing absorbers for reducing the momentum of the muon beam, rf cavities for restoring the momentum and strong solenoids for focusing the beam. Such a lattice is an essential feature of most designs for Neutrino Factories and Muon Colliders. Here, we explore three different approaches for designing ionization cooling channels based on periodic solenoidal focusing. Key parameters such as the engineering constraints arising from the length and separation between the solenoidal coils are systematically examined. In addition, we propose novel approaches for reducing the peak magnetic field inside the rf cavities, for example, by using bucked coils for focusing. Our lattice designs are numerically examined against two independent codes: The ICOOL and G4BL code. The performance of our proposed cooling channels is examined by implementing those to the front-end of a Neutrino Factory.

  16. Determining neutrino mass hierarchy from electron disappearance at a low energy neutrino factory

    International Nuclear Information System (INIS)

    Raut, Sushant K.

    2013-01-01

    Reactor neutrino experiments have recently measured the value of θ 13 , to be non-zero and moderately large. This makes the determination of the neutrino mass hierarchy possible. However, our lack of knowledge of δ CP results in a parameter degeneracy, which makes this task difficult. The electron neutrino disappearance probability does not depend on δ CP . Therefore, in principle, it is possible to determine the hierarchy independently of δ CP using this channel. Previous studies of neutrino factories have not considered this channel, because the effect of systematics in electron disappearance is substantial. However, we show that for the moderately large value of θ 13 measured, hierarchy determination is possible in spite of systematic effects. We consider a low energy neutrino factory (LENF) setup with a totally active scintillator detector (TASD) with charge-identification. We optimize the setup in muon energy and baseline, for different allowed values of θ 13 and runtime. We find that a LENF with baseline of around 1300 km and muon energy around 3-4 GeV is well suited for hierarchy determination. For the RENO best-fit value of θ 13 , this setup can determine the hierarchy at 5ω, for all values of δ CP and for both hierarchies. (author)

  17. THE PRIMARY TARGET FACILITY FOR A NEUTRINO FACTORY BASED ON MUON BEAMS

    International Nuclear Information System (INIS)

    HASSENEIN, A.; KAHN, S.A.; KING, B.J.; KIRK, H.G.; LUDEWIG, H.; PALMER, R.B.; PEARSON, C.E.; SAMULYAK, R.; SIMOS, N.; STUMER, I.; THIEBERGER, P.; WEGGEL, R.J.

    2001-01-01

    Neutrino beams from the decay of muons in a storage ring offer the prospect of very high flux, well-understood spectra, and equal numbers of electron and muon neutrinos, as desirable for detailed exploration of neutrino oscillations via long baseline detectors [1]. Such beams require. large numbers of muons, and hence a high performance target station at which a 1-4 MW proton beam of 16-24 GeV impinges on a compact target, all inside a high field solenoid channel to capture as much of the phase volume of soft pions as possible. A first concept was based on a carbon target, as reported in 2000 the Neutrino Factory Study-I [2]. A higher performance option based on a free mercury jet has been studied in 2001 as part of the Neutrino Factory Feasibility Study-II [3,4]. An overview of a mercury jet target facility is presented here, including requirements, design concept and summaries of simulated performance. Further details are presented in related papers at this conference

  18. Lifting degeneracies in the oscillation parameters by a neutrino factory

    International Nuclear Information System (INIS)

    Aoki, Mayumi; Hagiwara, Kaoru; Okamura, Naotoshi

    2005-01-01

    We study the potential of a very long baseline neutrino oscillation experiment with a neutrino factory and a large segmented water-Cerenkov calorimeter detector in resolving the degeneracies in the neutrino oscillation parameters; the sign of the larger mass-squared difference δm 13 2 , the sign of vertical bar U μ3 vertical bar 2 (=sin 2 θ ATM )-1/2, and a possible two-fold ambiguity in the determination of the CP phase δ MNS . We find that the above problems can be resolved even if the particle charges are not measured. The following results are obtained in our exploratory study for a neutrino factory which delivers 10 21 decaying μ + and μ - at 10 GeV and a 100 kton detector which is placed 2100 km away and is capable of measuring the event energy and distinguishing e + /- from μ + /-, but not their charges. The sign of δm 13 2 can be determined for 4 vertical bar U e3 vertical bar 2 (1- vertical bar U e3 vertical bar 2 )=sin 2 2θ RCT -bar 0.008. That of sin 2 θ ATM -1/2 can be resolved for sin 2 2θ ATM =0.96 when sin 2 2θ RCT -bar 0.06. The CP-violating phase δ MNS can be uniquely constrained for sin 2 2θ RCT -bar 0.02 if its true value is around 90 o or 270 o , while it can be constrained for sin 2 2θ RCT -bar 0.03 if its true value is around 0 deg. or 180 deg

  19. 16th International Workshop on Neutrino Factories and Future Neutrino Beam Facilities

    CERN Document Server

    2015-01-01

    These proceedings present the written contributions from participants of the 16th International Workshop on Neutrino Factories and Future Neutrino Beam Facilities (NUFACT 2014) that was held at the University of Glasgow (Glasgow, Scotland, United Kingdom) from 25-30 August 2014. This edition of the NUFACT annual meetings, which started in 1999, consisted of 24 plenary and 92 parallel talks and various poster sessions, with the participation of 124 delegates. Furthermore, the International Neutrino Summer School 2014 was held from 10-22 August 2014 at St Andrews, Scotland, in the two weeks before NUFACT 2014. It was intended for young scientists with an interest in neutrino physics in such a way that they would be able to participate and contribute to the NUFACT workshop as well. The objectives of the NUFACT workshops are to review progress on different studies for future accelerator-based neutrino oscillation facilities, with the goal to discover the mass hierarchy of neutrinos, CP violation in the leptonic s...

  20. A superconducting focusing solenoid for the neutrino factory linear accelerator

    International Nuclear Information System (INIS)

    Green, Michael A.; Lebedev, V.; Strauss, B.P.

    2001-01-01

    The proposed linear Accelerator that accelerates muons from 190 MeV to 2.45 GeV will use superconducting solenoids for focusing the muon beam. The accelerator will use superconducting RF cavities. These cavities are very sensitive to stay magnetic field from the focusing magnets. Superconducting solenoids can produce large stray fields. This report describes the 201.25 MHz acceleration system for the neutrino factory. This report also describes a focusing solenoid that delivers almost no stray field to a neighboring superconducting RF cavity

  1. General B factory design considerations

    International Nuclear Information System (INIS)

    Zisman, M.S.

    1992-12-01

    We describe the general considerations that go into the design of an asymmetric B factory collider. Justification is given for the typical parameters of such a facility, and the physics and technology challenges that arise from these parameter choices are discussed. Cost and schedule issues for a B factory are discussed briefly. A summary of existing proposals is presented, noting their similarities and differences

  2. Physics with a very long neutrino factory baseline

    International Nuclear Information System (INIS)

    Gandhi, Raj; Winter, Walter

    2007-01-01

    We discuss the neutrino oscillation physics of a very long neutrino factory baseline over a broad range of lengths (between 6000 km and 9000 km), centered on the 'magic baseline' (∼7500 km) where correlations with the leptonic CP phase are suppressed by matter effects. Since the magic baseline depends only on the density, we study the impact of matter density profile effects and density uncertainties over this range, and the impact of detector locations off the optimal baseline. We find that the optimal constant density describing the physics over this entire baseline range is about 5% higher than the average matter density. This implies that the magic baseline is significantly shorter than previously inferred. However, while a single detector optimization requires fine-tuning of the (very long) baseline length, its combination with a near detector at a shorter baseline is much less sensitive to the far detector location and to uncertainties in the matter density. In addition, we point out different applications of this baseline which go beyond its excellent correlation and degeneracy resolution potential. We demonstrate that such a long baseline assists in the improvement of the θ 13 precision and in the resolution of the octant degeneracy. Moreover, we show that the neutrino data from such a baseline could be used to extract the matter density along the profile up to 0.24% at 1σ for large sin 2 2θ 13 , providing a useful discriminator between different geophysical models

  3. Physics at a future Neutrino Factory and super-beam facility

    NARCIS (Netherlands)

    Bandyopadhyay, A.; Choubey, S.; Gandhi, R.; Goswami, S.; Roberts, B. L.; Bouchez, J.; Antoniadis, I.; Ellis, J.; Giudice, G. F.; Schwetz, T.; Umasankar, S.; Karagiorgi, G.; Aguilar-Arevalo, A.; Conrad, J. M.; Shaevitz, M. H.; Pascoli, S.; Geer, S.; Campagne, J. E.; Rolinec, M.; Blondel, A.; Campanelli, M.; Kopp, J.; Lindner, M.; Peltoniemi, J.; Dornan, P. J.; Long, K.; Matsushita, T.; Rogers, C.; Uchida, Y.; Dracos, M.; Whisnant, K.; Casper, D.; Chen, Mu-Chun; Popov, B.; Aysto, J.; Marfatia, D.; Okada, Y.; Sugiyama, H.; Jungmann, K.; Lesgourgues, J.; Zisman, M.; Tortola, M. A.; Friedland, A.; Davidson, S.; Antusch, S.; Biggio, C.; Donini, A.; Fernandez-Martinez, E.; Gavela, B.; Maltoni, M.

    2009-01-01

    The conclusions of the Physics Working Group of the International Scoping Study of a future Neutrino Factory and super-beam facility (the ISS) are presented. The ISS was carried out by the international community between NuFact05, (the 7th International Workshop on Neutrino Factories and

  4. Status of a MIND type Neutrino Factory Far Detector

    International Nuclear Information System (INIS)

    Bayes, R; Laing, A; Soler, F J P; Bross, A; Wands, R; Cervera, A; Ellis, M

    2013-01-01

    A realistic simulation and analysis of a Magnetized Iron Neutrino Detector (MIND) has been developed for the purpose of understanding the potential sensitivity of such a facility. The status of the MIND simulation and reconstruction as discussed in the interim design report is reviewed here. Priorities for producing a more realistic simulation for a reference design report will be discussed, as will be the steps that have already been taken towards an improved simulation.

  5. Apiary B Factory lattice design

    International Nuclear Information System (INIS)

    Donald, M.H.R.; Garren, A.A.

    1991-04-01

    The Apiary B Factory is a proposed high-intensity electron-positron collider. This paper will present the lattice design for this facility, which envisions two rings with unequal energies in the PEP tunnel. The design has many interesting optical and geometrical features due to the needs to conform to the existing tunnel, and to achieve the necessary emittances, damping times and vacuum. Existing hardware is used to a maximum extent. 8 figs. 1 tab

  6. Handbook factory planning and design

    CERN Document Server

    Wiendahl, Hans-Peter; Nyhuis, Peter

    2015-01-01

    This handbook introduces a methodical approach and pragmatic concept for the planning and design of changeable factories that act in strategic alliances to supply the ever-changing needs of the global market. In the first part, the change drivers of manufacturing enterprises and the resulting new challenges are considered in detail with focus on an appropriate change potential. The second part concerns the design of the production facilities and systems on the factory levels work place, section, building and site under functional, organisational, architectural and strategic aspects keeping in mind the environmental, health and safety aspects including corporate social responsibility. The third part is dedicated to the planning and design method that is based on a synergetic interaction of process and space. The accompanying project management of the planning and construction phase and the facility management for the effective utilization of the built premises close the book. -        Concise overview o...

  7. Status of Neutrino Factory R and D within the Muon Collaboration

    International Nuclear Information System (INIS)

    Rajendran Raja

    2004-01-01

    The authors describe the current status of the research within the Muon Collaboration towards realizing a Neutrino Factory. The authors describe briefly the physics motivation behind the neutrino factory approach to studying neutrino oscillations and the longer term goal of building the Muon Collider. The benefits of a step by step staged approach of building a proton driver, collecting and cooling muons followed by the acceleration and storage of cooled muons are emphasized. Several usages of cooled muons open up at each new stage in such an approach and new physics opportunities are realized at the completion of each stage

  8. Physics at a future Neutrino Factory and super-beam facility

    CERN Document Server

    Bandyopadhyay, A; Gandhi, R; Goswami, S; Roberts, B L; Bouchez, J; Antoniadis, I; Ellis, J; Giudice, G F; Schwetz, T; Umansankar, S; Karagiorgi, G; Aguilar-Arevalo, A; Conrad, J M; Shaevitz, M H; Pascoli, Silvia; Geer, S; Rolinec, M; Blondel, A; Campanelli, M; Kopp, J; Lindner, M; Peltoniemi, J; Dornan, P J; Long, K; Matsushita, T; Rogers, C; Uchida, Y; Dracos, M; Whisnant, K; Casper, D; Chen, Mu-Chun; Popov, B; Aysto, J; Marfatia, D; Okada, Y; Sugiyama, H; Jungmann, K; Lesgourgues, J; Murayama, France H; Zisman, M; Tortola, M A; Friedland, A; Antusch, S; Biggio, C; Donini, A; Fernandez-Martinez, E; Gavela, B; Maltoni, M; Lopez-Pavon, J; Rigolin, S; Mondal, N; Palladino, V; Filthaut, F; Albright, C; de Gouvea, A; Kuno, Y; Nagashima, Y; Mezzetoo, M; Lola, S; Langacker, P; Baldini, A; Nunokawa, H; Meloni, D; Diaz, M; King, S F; Zuber, K; Akeroyd, A G; Grossman, Y; Farzan, Y; Tobe, K; Aoki, Mayumi; Kitazawa, N; Yasuda, O; Petcov, S; Romanino, A; Chimenti, P; Vacchi, A; Smirnov, A Yu; Couce, Italy E; Gomez-Cadenas, J J; Hernandez, P; Sorel, M; Valle, J W F; Harrison, P F; Lundardini, C; Nelson, J K; Barger, V; Everett, L; Huber, P; Winter, W; Fetscher, W; van der Schaaf, A

    2009-01-01

    The conclusions of the Physics Working Group of the international scoping study of a future Neutrino Factory and super-beam facility (the ISS) are presented. The ISS was carried by the international community between NuFact05, (the 7th International Workshop on Neutrino Factories and Superbeams, Laboratori Nazionali di Frascati, Rome, June 21-26, 2005) and NuFact06 (Ivine, California, 24{30 August 2006). The physics case for an extensive experimental programme to understand the properties of the neutrino is presented and the role of high-precision measurements of neutrino oscillations within this programme is discussed in detail. The performance of second generation super-beam experiments, beta-beam facilities, and the Neutrino Factory are evaluated and a quantitative comparison of the discovery potential of the three classes of facility is presented. High-precision studies of the properties of the muon are complementary to the study of neutrino oscillations. The Neutrino Factory has the potential to provide ...

  9. Physics at a future Neutrino Factory and super-beam facility

    International Nuclear Information System (INIS)

    Bandyopadhyay, A; Choubey, S; Gandhi, R; Goswami, S; Roberts, B L; Bouchez, J; Antoniadis, I; Ellis, J; Giudice, G F; Schwetz, T; Umasankar, S; Karagiorgi, G; Aguilar-Arevalo, A; Conrad, J M; Shaevitz, M H; Pascoli, S; Geer, S; Campagne, J E; Rolinec, M; Blondel, A

    2009-01-01

    The conclusions of the Physics Working Group of the International Scoping Study of a future Neutrino Factory and super-beam facility (the ISS) are presented. The ISS was carried out by the international community between NuFact05, (the 7th International Workshop on Neutrino Factories and Super-beams, Laboratori Nazionali di Frascati, Rome, 21-26 June 2005) and NuFact06 (Ivine, CA, 24-30 August 2006). The physics case for an extensive experimental programme to understand the properties of the neutrino is presented and the role of high-precision measurements of neutrino oscillations within this programme is discussed in detail. The performance of second-generation super-beam experiments, beta-beam facilities and the Neutrino Factory are evaluated and a quantitative comparison of the discovery potential of the three classes of facility is presented. High-precision studies of the properties of the muon are complementary to the study of neutrino oscillations. The Neutrino Factory has the potential to provide extremely intense muon beams and the physics potential of such beams is discussed in the final section of the report.

  10. Superconducting magnets for induction linac phase-rotation in a neutrino factory

    International Nuclear Information System (INIS)

    Green, M.A.; Yu, S.

    2001-01-01

    The neutrino factory[1-3] consists of a target section where pions are produced and captured in a solenoidal magnetic field. Pions in a range of energies from 100 Mev to 400 MeV decay into muons in an 18-meter long channel of 1.25 T superconducting solenoids. The warm bore diameter of these solenoids is about 600 mm. The phase rotation section slows down the high-energy muon and speeds up the low energy muons to an average momentum of 200 MeV/c. The phase-rotation channel consists of three induction linac channels with a short cooling section and a magnetic flux reversal section between the first and second induction linacs and a drift space between the second and third induction linacs. The length of the phase rotation channel will be about 320 meters. The superconducting coils in the channel are 0.36 m long with a gap of 0.14 m between the coils. The magnetic induction within the channel will be 1.25. For 260 meters of the 320-meter long channel, the solenoids are inside the induction linac. This paper discusses the design parameters for the superconducting solenoids in the neutrino factory phase-rotation channel

  11. How well do we need to know the beam properties at a neutrino factory?

    International Nuclear Information System (INIS)

    Geer, S.; Crisan, C.

    2000-01-01

    In principle, a neutrino factory can produce a beam with a well known ν e and ν μ flux. In practice, the uncertainties on the muon beam properties will introduce uncertainties into the calculated neutrino fluxes. The authors explore the relationship between the beam systematics and the systematic uncertainties on predicted event rates at a far site. The desired precision with which they must know the beam momentum, direction, divergence, momentum spread, and polarization are discussed

  12. Information Management for Factory Planning and Design

    OpenAIRE

    Chen, Danfang

    2012-01-01

    This thesis is dedicated to the manufacturing industry for the improvement of information management within the factory planningand design domain, and for more efficient factory planning and design. Currently the manufacturing industry lacks sufficient methods for capturing, structuring, and representing information and knowledge for easy access, exchange, integration and reuse within the domain. Therefore the focus of this thesis is on information and knowledge management within factory plan...

  13. NEUTRINO FACTORY BASED ON MUON-STORAGE-RINGS TO MUON COLLIDERS: PHYSICS AND FACILITIES

    International Nuclear Information System (INIS)

    PARSA, Z.

    2001-01-01

    Intense muon sources for the purpose of providing intense high energy neutrino beams (ν factory) represents very interesting possibilities. If successful, such efforts would significantly advance the state of muon technology and provides intermediate steps in technologies required for a future high energy muon collider complex. High intensity muon: production, capture, cooling, acceleration and multi-turn muon storage rings are some of the key technology issues that needs more studies and developments, and will briefly be discussed here. A muon collider requires basically the same number of muons as for the muon storage ring neutrino factory, but would require more cooling, and simultaneous capture of both ± μ. We present some physics possibilities, muon storage ring based neutrino facility concept, site specific examples including collaboration feasibility studies, and upgrades to a full collider

  14. NEUTRINO FACTORY BASED ON MUON-STORAGE-RINGS TO MUON COLLIDERS: PHYSICS AND FACILITIES.

    Energy Technology Data Exchange (ETDEWEB)

    PARSA,Z.

    2001-06-18

    Intense muon sources for the purpose of providing intense high energy neutrino beams ({nu} factory) represents very interesting possibilities. If successful, such efforts would significantly advance the state of muon technology and provides intermediate steps in technologies required for a future high energy muon collider complex. High intensity muon: production, capture, cooling, acceleration and multi-turn muon storage rings are some of the key technology issues that needs more studies and developments, and will briefly be discussed here. A muon collider requires basically the same number of muons as for the muon storage ring neutrino factory, but would require more cooling, and simultaneous capture of both {+-} {mu}. We present some physics possibilities, muon storage ring based neutrino facility concept, site specific examples including collaboration feasibility studies, and upgrades to a full collider.

  15. THE R AND D PROGRAM FOR TARGETRY AT A NEUTRINO FACTORY

    International Nuclear Information System (INIS)

    MCDONALD, K.T.; BROWN, K.A.; FINFROCK, C.C.; GASSNER, D.M.; GREENE, G.A.; HANSON, A.L.; KAHN, S.A.; KING, B.J.; KIRK, H.G.; LUDEWIG, H.; PALMER, R.B.; PENDZICK, A.F.; PRIGL, R.; SAMULYAK, R.; SCADUTO, J.; SIMOS, N.; THIEBERGER, P.; TSANG, T.Y.F.; WANG, H.; WEGGEL, R.J.

    2001-01-01

    The need for intense muon beams for muon colliders [1] and for neutrino factories based on muon storage rings [2,3,4] leads to a concept of 1-4 MW proton beams incident a moving target that is inside a 20-T solenoid magnet, with a mercury jet as a preferred example. Novel technical issues for such a system include disruption of the mercury jet by the proton beam and distortion of the jet on entering the solenoid, as well as more conventional issues of materials lifetime and handling of activated materials in an intense radiation environment. As part of the R and D program [5] of the Neutrino Factory and Muon Collider Collaboration, R and D effort related to targetry is being performed within the context of BNL E951 [6], first results of which are discussed here and in other contributions to this conference

  16. MUON POLARIZATION EFFECTS IN THE FRONT END OF THE NEUTRINO FACTORY

    International Nuclear Information System (INIS)

    FERNOW, R.C.; GALLARDO, J.C.; FUKUI, Y.

    2000-01-01

    The authors summarize the methods used for simulation of polarization effects in the front end of a possible neutrino factory. They first discuss the helicity of muons in the pion decay process. They find that, neglecting acceptance considerations, the average helicity asymptotically approaches a magnitude of 0.185 at large pion momenta. Next they describe the methods used for tracking the spin through the complicated electromagnetic field configurations in the front end of the neutrino factory, including rf phase rotation and ionization cooling channels. Various depolarizing effects in matter are then considered, including multiple Coulomb scattering and elastic scattering from atomic electrons. Finally, they include all these effects in a simulation of a 480 m long, double phase rotation front end scenario

  17. Superbeams plus Neutrino Factory the golden path to leptonic CP violation

    CERN Document Server

    Burguet-Castell, J; Gómez-Cadenas, J J; Hernández, Pilar; Mena, O

    2002-01-01

    Superbeams (SB) and Neutrino Factories (NF) are not alternative facilities for exploring neutrino oscillation physics, but successive steps. The correct strategy is to contemplate the combination of their expected physics results. We show its important potential on the disappearance of fake degenerate solutions in the simultaneous measurement of $\\theta_{13}$ and leptonic CP violation. Intrinsic, sign($\\Delta m_{13}^2$) and $\\theta_{23}$ degeneracies are shown to be extensively eliminated when the results from one NF baseline and a SB facility are combined. A key point is the different average neutrino energy and baseline of the facilities. For values of $\\theta_{13}$ near its present limit, the short NF baseline, e.g. L=732 km,becomes, after such a combination, a very interesting distance. For smaller $\\theta_{13}$, an intermediate NF baseline of $O(3000$km) is still required.

  18. Superbeams plus neutrino factory: the golden path to leptonic CP violation

    International Nuclear Information System (INIS)

    Burguet-Castell, J.; Gavela, M.B.; Gomez-Cadenas, J.J.; Hernandez, P.; Mena, O.

    2002-01-01

    Superbeams (SB) and neutrino factories (NF) are not alternative facilities for exploring neutrino oscillation physics, but successive steps. The correct strategy is to contemplate the combination of their expected physics results. We show its important potential on the disappearance of fake degenerate solutions in the simultaneous measurement of θ 13 and leptonic CP violation. Intrinsic, sign(Δm 13 2 ) and θ 23 degeneracies are shown to be extensively eliminated when the results from one NF baseline and a SB facility are combined. A key point is the different average neutrino energy and baseline of the facilities. For values of θ 13 near its present limit, the short NF baseline, e.g., L=732 km, becomes, after such a combination, a very interesting distance. For smaller θ 13 , an intermediate NF baseline of O(3000 km) is still required

  19. Magnet Misalignment Studies for the Front-end of the Neutrino Factory

    CERN Document Server

    Prior, G; Stratakis, D; Neuffer, D; Snopok, P; Rogers, C

    2013-01-01

    In the Neutrino Factory front-end the muon beam coming from the interaction of a high-power (4 MW) proton beam on a mercury jet target is transformed through a buncher, a phase rotator and an ionization cooling channel before entering the downstream acceleration system. The muon front-end channel is densely packed with solenoid magnets, normal conducting radio-frequency cavities and absorber windows for the cooling section. The tolerance to the misalignment of the different components has to be determined in order on one hand to set the limits beyond which the performance of the front-end channel would be degraded; on the other hand to optimize the design and assembly of the front-end cells such that the component alignment can be checked and corrected for where crucial for the performance of the channel. In this paper we show the results of some of the simulations of the frontend channel performance where the magnetic field direction has been altered compared to the baseline.

  20. The Mathematics of Symmetrical Factorial Designs

    Indian Academy of Sciences (India)

    The Mathematics of Symmetrical Factorial Designs. Mausumi Bose (nee Sen) obtained her MSc degree in. Statistics from the Calcutta. University and PhD degree from the Indian Statistical. Institute. She is on the faculty of the Indian. Statistical Institute. Her main field of research interest is design and analysis of experiments.

  1. A conceptual design of circular Higgs factory

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Yunhai

    2016-11-30

    Similar to a super B-factory, a circular Higgs factory (CHF) will require strong focusing systems near the interaction points and a low-emittance lattice in the arcs to achieve a factory luminosity. At electron beam energy of 125 GeV, beamstrahlung effects during the collision pose an additional challenge to the collider design. In particular, a large momentum acceptance at the 2% level is necessary to retain an adequate beam lifetime. This turns out to be the most challenging aspect in the design of a CHF. In this paper, an example will be provided to illustrate the beam dynamics in a CHF, emphasizing the chromatic optics. Basic optical modules and advanced analysis will be presented. Most importantly, we will show that 2% momentum aperture is achievable.

  2. Performance of the MIND detector at a Neutrino Factory using realistic muon reconstruction

    International Nuclear Information System (INIS)

    Cervera, A.; Laing, A.; Martin-Albo, J.; Soler, F.J.P.

    2010-01-01

    A Neutrino Factory producing an intense beam composed of ν e (ν-bar e ) and ν-bar μ (ν μ ) from muon decays has been shown to have the greatest sensitivity to the two currently unmeasured neutrino mixing parameters, θ 13 and δ CP . Using the 'wrong-sign muon' signal to measure ν e →ν μ (ν-bar e →ν-bar μ ) oscillations in a 50 kt Magnetised Iron Neutrino Detector (MIND) sensitivity to δ CP could be maintained down to small values of θ 13 . However, the detector efficiencies used in these previous studies were calculated assuming perfect pattern recognition. In this paper, MIND is reassessed taking into account, for the first time, a realistic pattern recognition for the muon candidate. Reoptimisation of the analysis utilises a combination of methods, including a multivariate analysis similar to the one used in MINOS, to maintain high efficiency while suppressing backgrounds, ensuring that the signal selection efficiency and the background levels are comparable or better than the ones in previous analyses. As a result MIND remains the most sensitive future facility for the discovery of CP violation from neutrino oscillations.

  3. International Scoping Study (ISS) for a future neutrino factory and Super-Beam facility. Detectors and flux instrumentation for future neutrino facilities

    International Nuclear Information System (INIS)

    Abe, T; Aihara, H; Andreopoulos, C; Ankowski, A; Badertscher, A; Battistoni, G; Blondel, A; Bouchez, J; Bross, A; Ellis, M; Bueno, A; Camilleri, L; Campagne, J E; Cazes, A; Cervera-Villanueva, A; De Lellis, G; Di Capua, F; Ereditato, A; Esposito, L S

    2009-01-01

    This report summarises the conclusions from the detector group of the International Scoping Study of a future Neutrino Factory and Super-Beam neutrino facility. The baseline detector options for each possible neutrino beam are defined as follows: 1. A very massive (Megaton) water Cherenkov detector is the baseline option for a sub-GeV Beta Beam and Super Beam facility. 2. There are a number of possibilities for either a Beta Beam or Super Beam (SB) medium energy facility between 1-5 GeV. These include a totally active scintillating detector (TASD), a liquid argon TPC or a water Cherenkov detector. 3. A 100 kton magnetized iron neutrino detector (MIND) is the baseline to detect the wrong sign muon final states (golden channel) at a high energy (20-50 GeV) neutrino factory from muon decay. A 10 kton hybrid neutrino magnetic emulsion cloud chamber detector for wrong sign tau detection (silver channel) is a possible complement to MIND, if one needs to resolve degeneracies that appear in the δ-θ 13 parameter space.

  4. B factory rf system design issues

    International Nuclear Information System (INIS)

    Zisman, M.S.

    1992-06-01

    We discuss the issues of relevance to the design of a B factory RF system. First, the general parameter regime is outlined, and the reasons behind certain commonly made choices are indicated. This regime involves high beam currents, and many relatively short bunches. Next, the physics difficulties associated with coupled-bunch instabilities are described briefly. We then describe in general terms the alternative approaches taken by various B factory designers, the motivation for these choices, and the technical issues raised by them. Technical solutions have been proposed for both the room-temperature and the superconducting RF scenarios, and considerable R ampersand D is being carried out worldwide to confirm and optimize these solutions

  5. B factory RF system design issues

    International Nuclear Information System (INIS)

    Zisman, M.S.

    1992-01-01

    We discuss the issues of relevance to the design of a B factory RF system. First, the general parameter regime is outlined, and the reasons behind certain commonly made choices are indicated. This regime involves high beam currents, and many relatively short bunches. Next, the physics difficulties associated with coupled-bunch instabilities are described briefly. We then describe in general terms the alternative approaches taken by various B factory designers, the motivation for these choices, and the technical issues raised by them. Technical solutions have been proposed for both the room-temperature and the superconducting RF scenarios, and considerable R ampersand D is being carried out worldwide to confirm and optimize these solutions

  6. Design studies for the Positron Factory

    International Nuclear Information System (INIS)

    Okada, S.; Sunaga, H.; Kaneko, H.; Masuno, S.; Kawasuso, A.; Sakai, T.; Takizawa, H.; Yotsumoto, K.; Honda, Y.; Tagawa, S.

    1996-01-01

    In the design study for the Positron Factory, a feasibility of simultaneous extraction of multi-channel monoenergetic positron beams, which had been proposed at the previous conference (Linac 94), was demonstrated by an experiment using an electron linac. On the basis of the experimental result, an efficient moderator structure, which is composed of honeycomb-like assembled moderator foils and reflectors, is proposed. (author)

  7. Polarized parton distributions from charged-current deep-inelastic scattering and future neutrino factories

    CERN Document Server

    Forte, Stefano; Ridolfi, G; Forte, Stefano; Mangano, Michelangelo L.; Ridolfi, Giovanni

    2001-01-01

    We discuss the determination of polarized parton distributions from charged-current deep-inelastic scattering experiments. We summarize the next-to-leading order treatment of charged-current polarized structure functions, their relation to polarized parton distributions and scale dependence, and discuss their description by means of a next-to-leading order evolution code. We discuss current theoretical expectations and positivity constraints on the unmeasured C-odd combinations Delta q-Delta qbar of polarized quark distributions, and their determination in charged-current deep-inelastic scattering experiments. We give estimates of the expected errors on charged-current structure functions at a future neutrino factory, and perform a study of the accuracy in the determination of polarized parton distributions that would be possible at such a facility. We show that these measurements have the potential to distinguish between different theoretical scenarios for the proton spin structure.

  8. Polarized parton distributions from charged-current deep-inelastic scattering and future neutrino factories

    International Nuclear Information System (INIS)

    Forte, Stefano; Mangano, Michelangelo L.; Ridolfi, Giovanni

    2001-01-01

    We discuss the determination of polarized parton distributions from charged-current deep-inelastic scattering experiments. We summarize the next-to-leading-order treatment of charged-current polarized structure functions, their relation to polarized parton distributions and scale dependence, and discuss their description by means of a next-to-leading-order evolution code. We discuss current theoretical expectations and positivity constraints on the unmeasured C-odd combinations Δq-Δq-bar of polarized quark distributions, and their determination in charged-current deep-inelastic scattering experiments. We give estimates of the expected errors on charged-current structure functions at a future neutrino factory, and perform a study of the accuracy in the determination of polarized parton distributions that would be possible at such a facility. We show that these measurements have the potential to distinguish between different theoretical scenarios for the proton spin structure

  9. Power Deposition due to Muon Decay Losses in a Neutrino Factory

    CERN Document Server

    Keil, Eberhard

    2000-01-01

    The power in the charged muon decay products, deposited per unit distance, depends on the muon energy only through the relativistic factor beta. For a typical neutrino factory it is about one Watt/m, multiplied by the number of passes through a particular component. The power is highest in the muon decay ring, where the muon lifetime cooresponds to about 150 turns. The electrons or positrons from muon decay in the long straight section may remain inside the vacuum chamber, until they are lost at the beginning of the arcs, because of their large energy errors, that are enhanced by synchrotron radiation losses. The power losses along the straight section and the arcs are studied by computer simulation, and the results are presented. About two thirds of the power ends up in the straight section, the remainder in the matching section and in the first half of the dispersion suppressor.

  10. In situ determination of Earth matter density in a neutrino factory

    Science.gov (United States)

    Minakata, Hisakazu; Uchinami, Shoichi

    2007-04-01

    We point out that an accurate in situ determination of the earth matter density ρ is possible in neutrino factory by placing a detector at the magic baseline, L=2π/GFNe where Ne denotes electron number density. The accuracy of matter density determination is excellent in a region of relatively large θ13 with fractional uncertainty δρ/ρ of about 0.43%, 1.3%, and ≲3% at 1σ CL at sin⁡22θ13=0.1, 10-2, and 3×10-3, respectively. At smaller θ13 the uncertainty depends upon the CP phase δ, but it remains small, 3% 7% in more than 3/4 of the entire region of δ at sin⁡22θ13=10-4. The results would allow us to solve the problem of obscured CP violation due to the uncertainty of earth matter density in a wide range of θ13 and δ. It may provide a test for the geophysical model of the earth, or it may serve as a method for a stringent test of the Mikheyev-Smirnov-Wolfenstein theory of neutrino propagation in matter once an accurate geophysical estimation of the matter density is available.

  11. Neutrino Physics

    CERN Multimedia

    CERN. Geneva; Dydak, Friedrich

    2001-01-01

    Starting from a review of theoretical concepts and experimental results in the early years of neutrino physics after Pauli's 1930 letter, today's double role of the neutrino as a cornerstone of the Standard Model and as a promising probe of physics beyond the Standard Model will be discussed. Topics comprise: - Conventional neutrino beams - Neutrinos as probes of the nucleon structure - Neutrinos from the universe - Dirac or Majorana neutrinos - Neutrino oscillations - MNS matrix - CP violation in the lepton sector - Neutrino factory.

  12. Neutrino Physics

    CERN Multimedia

    CERN. Geneva. Audiovisual Unit

    2002-01-01

    Starting from a review of theoretical concepts and experimental results in the early years of neutrino physics after Pauli's 1930 letter, today's double role of the neutrino as a cornerstone of the Standard Model and as a promising probe of physics beyond the Standard Model will be discussed. Topics comprise: - Conventional neutrino beams - Neutrinos as probes of the nucleon structure - Neutrinos from the universe - Dirac or Majorana neutrinos - Neutrino oscillations - MNS matrix - CP violation in the lepton sector - Neutrino factory.

  13. Radiation safety design of super KEKB factory

    International Nuclear Information System (INIS)

    Sanami, Toshiya

    2015-01-01

    The SuperKEKB factory, which was scheduled to start operation early 2015, is an electron-positron collider designed to produce an 80x10"3"4-1/cm"2/s luminosity, which is 40 times greater than the KEKB factory. Built to investigate CP violation and 'new physics' beyond the Standard Model, the facility consists of a 7-GeV electron/3.5-GeV positron linac, a 1.1- GeV positron damping ring, beam transport, and a 7-GeV electron/4-GeV positron collider. To meet this level of luminosity, the collider will be operated with a small beam size and a large crossing angle at the interaction point. According to particle tracking simulations, beam losses under these conditions will be 35 times more than those previously operated. To help optimise shielding configurations, leakage radiation and induced activity are estimated through empirical equations and detailed Monte-Carlo simulations using MARS15 code for the interaction region, beam halo collimators, emergency pathways, ducts, forward direction tunnels, and positron production target. Examples of shielding strategies are presented to reduce both leakage dose and airborne activity for several locations in the facility. (authors)

  14. Flow-based approach for holistic factory engineering and design

    OpenAIRE

    Constantinescu, C.; Westkämper, E.

    2010-01-01

    The engineering of future factories requires digital tools along life cycle phases from investment planning to ramp-up. Manufacturers need scientific-based integrated highly dynamic data management systems for the participative and integrated factory planning. The paper presents a new approach for the continuously integrated product design, factory and process planning, through a service-oriented architecture for the implementation of digital factory tools. A first prototype of the digital fa...

  15. High-gravity brewing utilizing factorial design

    Directory of Open Access Journals (Sweden)

    R. B. Almeida

    2000-06-01

    Full Text Available A number of factors can influence the behavior of yeast during fermentation. Some of these factors (initial wort concentration, initial pH and percentage of corn syrup in the composition of the wort were studied in order to determine their influence on the productivity of fermentation. Fermentations were carried out at 25ºC utilizing a 2³ factorial design of these factors. The results showed that the percentage of corn syrup had no influence on process productivity, whereas initial pH and especially initial wort concentration did. It can be concluded that using pH and initial wort concentration values higher than those utilized in this work (5.5 and 20ºP, respectively will result in a higher productivity.

  16. An R and D program for targetry and capture at a neutrino factory and muon collider source

    International Nuclear Information System (INIS)

    Hassenein, A.; Bernadon, A.; Beshears, D.L.; Brown, K.A.; Cates, M.C.; Fabich, A.; Fernow, R.C.; Finfrock, C.C.; Fukui, Y.; Gabriel, T.A.; Gassner, D.M.; Green, M.A.; Greene, G.A.; Haines, J.R.; Johnson, C.D.; Kahn, S.A.; King, B.J.; Kirk, H.G.; Lettry, J.; Lu, C.; Ludewig, H.; McDonald, K.T.; Miller, J.R.; Mokhov, N.V.; Palmer, R.B.; Pendzick, A.F.; Prigl, R.; Ravn, H.; Reginato, L.L.; Riemer, B.W.; Samulyak, R.; Scaduto, J.; Simos, N.; Spampinato, P.T.; Thieberger, P.; Tsai, C.-C.; Tsang, T.Y.F.; Wang, H.; Weggel, R.J.; Zeller, A.

    2003-01-01

    The need for intense muon beams for muon colliders and for neutrino factories based on muon storage rings leads to a concept of 1-4 MW proton beams incident on a moving target that is inside a 20-T solenoid magnet, with a mercury jet as a preferred example. Novel technical issues for such a system include disruption of the mercury jet by the proton beam and distortion of the jet on entering the solenoid, as well as more conventional issues of materials lifetime and handling of activated materials in an intense radiation environment. As part of the R and D program of the Neutrino Factory and Muon Collider Collaboration, an R and D effort related to targetry is being performed within the context of experiment E951 at Brookhaven National Laboratory, first results of which are reported here

  17. Issues in Acceleration of A Muon Beam for a Neutrino Factory

    International Nuclear Information System (INIS)

    J. Delayen; D. Douglas; L. Harwood; V. Lebedev; C. Leemann; L. Merminga

    2001-01-01

    We have developed a concept for acceleration of a large phase-space, pulsed muon beam from 190 MeV to 50 GeV as part of a collaborative study of the feasibility of a neutrino factory based on in-flight decay of muons. The muon beam's initial energy spread was ∼20% and each bunch has the physical size of a soccer ball. Production of the muons will be quite expensive, so prevention of loss due to scraping or decay is critical. The former drives the system to large apertures and the latter calls for high real-estate-average gradients. The solution to be presented utilizes a 3 GeV linac to capture the beam, a 4-pass recirculating linac to get the beam to 10 GeV, and then a 5-pass linac to get the beam to 50 GeV. Throughout the system, longitudinal dynamics issues far outweighed transverse dynamics issues. This paper focuses on the issues surrounding the choice of superconducting rf structures over copper structures

  18. Architectural design of experience based factory model for software ...

    African Journals Online (AJOL)

    architectural design. Automation features are incorporated in the design in which workflow system and intelligent agents are integrated, and the facilitation of cloud environment is empowered to further support the automation. Keywords: architectural design; knowledge management; experience factory; workflow;

  19. Argonne Tau-charm factory collider design study

    International Nuclear Information System (INIS)

    Teng, L.C.; Crosbie, E.A.; Norem, J.

    1995-01-01

    The design approach and design principles for a Tau-charm Factory at Argonne were studied. These studies led to a set of preliminary parameters and tentative component features as presented in this paper

  20. Argonne Tau-charm Factory collider design study

    International Nuclear Information System (INIS)

    Teng, L.C.; Crosbie, E.A.; Norem, J.; Repond, J.

    1996-01-01

    The design approach and design principles for a Tau-charm Factory at Argonne were studied. These studies led to a set of preliminary parameters and tentative component features as presented in this paper. copyright 1996 American Institute of Physics

  1. The ideal neutrino beams

    Science.gov (United States)

    Lindroos, Mats

    2009-06-01

    The advance in neutrino oscillation physics is driven by the availability of well characterized and high flux neutrino beams. The three present options for the next generation neutrino oscillation facility are super beams, neutrino factories and beta-beams. A super-beam is a very high intensity classical neutrino beam generated by protons impinging on a target where the neutrinos are generated by the secondary particles decaying in a tunnel down streams of the target. In a neutrino factory the neutrinos are generated from muons decaying in a storage ring with long straight sections pointing towards the detectors. In a beta-beam the neutrinos are also originating from decay in a storage ring but the decaying particles are radioactive ions rather than muons. I will in this presentation review the three options and discuss the pros and cons of each. The present joint design effort for a future high intensity neutrino oscillation in Europe within a common EU supported design study, EURONU, will also be presented. The design study will explore the physics reach, the detectors, the feasibility, the safety issues and the cost for each of the options so that the the community can take a decision on what to build when the facilities presently under exploitation and construction have to be replaced.

  2. The ideal neutrino beams

    CERN Document Server

    Lindroos, Mats

    2009-01-01

    The advance in neutrino oscillation physics is driven by the availability of well characterized and high flux neutrino beams. The three present options for the next generation neutrino oscillation facility are super beams, neutrino factories and beta-beams. A super-beam is a very high intensity classical neutrino beam generated by protons impinging on a target where the neutrinos are generated by the secondary particles decaying in a tunnel down streams of the target. In a neutrino factory the neutrinos are generated from muons decaying in a storage ring with long straight sections pointing towards the detectors. In a beta-beam the neutrinos are also originating from decay in a storage ring but the decaying particles are radioactive ions rather than muons. I will in this presentation review the three options and discuss the pros and cons of each. The present joint design effort for a future high intensity neutrino oscillation in Europe within a common EU supported design study, EURONU, will also be presented....

  3. Implementing Clinical Research Using Factorial Designs: A Primer.

    Science.gov (United States)

    Baker, Timothy B; Smith, Stevens S; Bolt, Daniel M; Loh, Wei-Yin; Mermelstein, Robin; Fiore, Michael C; Piper, Megan E; Collins, Linda M

    2017-07-01

    Factorial experiments have rarely been used in the development or evaluation of clinical interventions. However, factorial designs offer advantages over randomized controlled trial designs, the latter being much more frequently used in such research. Factorial designs are highly efficient (permitting evaluation of multiple intervention components with good statistical power) and present the opportunity to detect interactions amongst intervention components. Such advantages have led methodologists to advocate for the greater use of factorial designs in research on clinical interventions (Collins, Dziak, & Li, 2009). However, researchers considering the use of such designs in clinical research face a series of choices that have consequential implications for the interpretability and value of the experimental results. These choices include: whether to use a factorial design, selection of the number and type of factors to include, how to address the compatibility of the different factors included, whether and how to avoid confounds between the type and number of interventions a participant receives, and how to interpret interactions. The use of factorial designs in clinical intervention research poses choices that differ from those typically considered in randomized clinical trial designs. However, the great information yield of the former encourages clinical researchers' increased and careful execution of such designs. Copyright © 2017. Published by Elsevier Ltd.

  4. JINR tau-charm factory design study

    International Nuclear Information System (INIS)

    Perel'shtejn, E.; Aleksandrov, V.; Antropov, V.

    1993-01-01

    The review on tau-charm factory in JINR (Dubna) is presented. The structure scheme of tau-charm factory is described. The problems on injection complex are discussed: the composition, the working regime and parameters. The magnetic lattice of a booster is described. A versatile magnet lattice is used in tau-charm collider. It can realize both conventional flat beam scheme and monochromatization scheme. The results of chromaticity correction in high emittance lattice are presented. The list of parameters of tau-charm collider is given. The technical proposal of magnetic elements of booster and collider and their power supplies is made, as well as RF power supply in collider and vacuum system in its periodic cell. 12 refs.; 12 figs.; 3 tabs

  5. CONFOUNDING STRUCTURE OF TWO-LEVEL NONREGULAR FACTORIAL DESIGNS

    Institute of Scientific and Technical Information of China (English)

    Ren Junbai

    2012-01-01

    In design theory,the alias structure of regular fractional factorial designs is elegantly described with group theory.However,this approach cannot be applied to nonregular designs directly. For an arbitrary nonregular design,a natural question is how to describe the confounding relations between its effects,is there any inner structure similar to regular designs? The aim of this article is to answer this basic question.Using coefficients of indicator function,confounding structure of nonregular fractional factorial designs is obtained as linear constrains on the values of effects.A method to estimate the sparse significant effects in an arbitrary nonregular design is given through an example.

  6. Mainz/PSI φ-factory design considerations

    International Nuclear Information System (INIS)

    Streun, A.

    1991-01-01

    Design considerations for a φ-factory with a Luminosity of the order of 10 33 cm -2 s -1 lead to the concept of a multi-bunch round beam double storage ring with superconducting solenoids for micro-beta focusing and beam rotation. Simulations of the beam-beam-interaction indicate, that significantly higher beam-beam-parameters may become possible with round beams. A rough draft design of a round beam φ-factory is presented. (orig.)

  7. Results of a neutrino oscillation experiment performed at a meson factory beam-stop

    International Nuclear Information System (INIS)

    Mitchell, J.W.

    1989-04-01

    This document describes a neutrino oscillation experiment performed at the Los Alamos Meson Physics Facility. The oscillation mode searched for is /bar /nu///sub μ/ → /bar /nu///sub e/. The first chapter is a review of the known properties of the neutrino and a description of the phenomenon of neutrino oscillation. Previous experimental limits on this unobserved phenomenon are also given. The second chapter describes the experimental apparatus used by the E645 experiment to detect neutrinos produced in the LAMPF beam stop. The salient features of the detector are its large mass (20 tons of CH 2 ), its fine segmentation (to allow good particle tracking), good energy resolution, its recording of the history both before and after tracks appear in the detector, an active cosmic-ray anticoincidence shield, and 2000 gm/cm 2 of passive cosmic-ray shielding. It is located 26.8 m from the neutrino source, which has a mean neutrino energy of 40 MeV. The third chapter details the reduction of the 1.3 million event data sample to a 49 event sample of neutrino candidates. Principle backgrounds are Michel electrons from stopping cosmic-ray muons and protons from np elastic scattering by cosmic-ray neutrons. The fourth chapter explains how background levels from neutrino-nuclear scattering are predicted. The result of a maximum-likelihood analysis reveals no evidence for oscillation. 90% confidence levels are set at δm 2 = .10 eV 2 for large mixing and sin 2 (2θ) = .014 for large δm 2 . 82 refs., 18 figs., 55 tabs

  8. Designing fractional factorial split-plot experiments using integer programming

    DEFF Research Database (Denmark)

    Capehart, Shay R.; Keha, Ahmet; Kulahci, Murat

    2011-01-01

    factorial (FF) design, with the restricted randomisation structure to account for the whole plots and subplots. We discuss the formulation of FFSP designs using integer programming (IP) to achieve various design criteria. We specifically look at the maximum number of clear two-factor interactions...

  9. Design, analysis and presentation of factorial randomised controlled trials

    Directory of Open Access Journals (Sweden)

    Little Paul

    2003-11-01

    Full Text Available Abstract Background The evaluation of more than one intervention in the same randomised controlled trial can be achieved using a parallel group design. However this requires increased sample size and can be inefficient, especially if there is also interest in considering combinations of the interventions. An alternative may be a factorial trial, where for two interventions participants are allocated to receive neither intervention, one or the other, or both. Factorial trials require special considerations, however, particularly at the design and analysis stages. Discussion Using a 2 × 2 factorial trial as an example, we present a number of issues that should be considered when planning a factorial trial. The main design issue is that of sample size. Factorial trials are most often powered to detect the main effects of interventions, since adequate power to detect plausible interactions requires greatly increased sample sizes. The main analytical issues relate to the investigation of main effects and the interaction between the interventions in appropriate regression models. Presentation of results should reflect the analytical strategy with an emphasis on the principal research questions. We also give an example of how baseline and follow-up data should be presented. Lastly, we discuss the implications of the design, analytical and presentational issues covered. Summary Difficulties in interpreting the results of factorial trials if an influential interaction is observed is the cost of the potential for efficient, simultaneous consideration of two or more interventions. Factorial trials can in principle be designed to have adequate power to detect realistic interactions, and in any case they are the only design that allows such effects to be investigated.

  10. Neutrinos

    CERN Multimedia

    CERN. Geneva

    2004-01-01

    The Standard Model predicts that the neutrinos are massless and do not mix. Generic extensions of the Standard Model predict that neutrinos are massive (but, very likely, much lighter than the charged fermions). Therefore, the search for neutrino masses and mixing tests the Standard Model and probes new phasics. Measurements of various features of the fluxes of atmospheric, solar and, more recently, reactor neutrinos have provided evidence for neutrino oscillations and therefore for neutrino masses and mixing. These results have significant theoretical implications: new physics exists, and its scale can be estimated. There are interesting lessons for grand unified theories and for models of extra dimensions. The measured neutrino flavor parameters pose a challenge to flavor models.

  11. Shielding design of RIKEN RI Beam Factory

    Energy Technology Data Exchange (ETDEWEB)

    Uwamino, Yoshitomo; Fukunishi, Nobuhisa [Institute of Physical and Chemical Research, Wako, Saitama (Japan); Oishi, Koji [Shimizu Corp., Tokyo (Japan)

    2000-03-01

    Construction of the RIKEN RI Beam Factory is started, and the phase 1 will be finished by the end of March 2003. Two ring cyclotrons including one superconducting machine and two Big RIPSs will be constructed in the phase 1. Heavy ions of proton to uranium will be accelerated up to 400 MeV/u (A<40) and 150 MeV/u for uranium at an intensity of 10{sup 13} pps. Neutron production by the 400 MeV/u {sup 20}Ne beam was measured at HIMAC of NIRS and it was used for the source term of the shielding calculations. The deep penetration of high-energy neutrons was calculated by using the ANISN code with the DLC-119/HILO86R group constants and also by using the HETC code. The ANISN results were modified by using the HETC results and the shielding experiment at ISIS, and they were fitted by a simple formula for practical use. High-energy neutron penetrations of slantwise injection and the reflection probabilities of iron slab were calculated with the HETC code, and these results were used for the estimation of the thickness for the iron local shielding of Big RIPSs. Induced radioactivity in the air, accelerator components and the building, and the skyshine effect were also estimated. (author)

  12. Constructing General Orthogonal Fractional Factorial Split-Plot Designs

    NARCIS (Netherlands)

    Sartono, B.; Goos, P.; Schoen, E.

    2015-01-01

    While the orthogonal design of split-plot fractional factorial experiments has received much attention already, there are still major voids in the literature. First, designs with one or more factors acting at more than two levels have not yet been considered. Second, published work on nonregular

  13. Kaon factories

    International Nuclear Information System (INIS)

    Craddock, M.K.

    1983-03-01

    Kaon factories would provide beams 100-1000 times more intense than those available from present accelerators in the 10-30 GeV range. More intense or cleaner secondary beams of kaons, antiprotons and neutrinos would be of particular interest for high precision experiments and studies of rare processes in both particle and nuclear physics, e.g. symmetry violations in K-decay, neutrino scattering, meson and baryon spectroscopy, hypernuclei, exotic atoms, K + studies of nuclear density and resonance propagation in nuclei. The various accelerators proposed include both fast-cycling synchrotrons providing 100 μA proton beams at 15 to 32 GeV and superconducting isochronous ring cyclotrons giving 100-400 μA at up to 15 GeV. This paper describes these designs and the various technical problems associated with them

  14. Meson factories

    International Nuclear Information System (INIS)

    Dicello, J.F.; Zaider, M.; Bradbury, J.N.

    1979-01-01

    Technological improvements in accelerator design in the 1960's resulted in the capability to develop medium-energy proton accelerators with beam intensities of almost 1 mA. These beams are able to produce fluxes of secondary particles, including pions, muons, neutrinos, and neutrons, which are as much as 10,000 times as intense as those previously available. Those machines built for optimum meson production are commonly called meson factories. The characteristics of these facilities are reviewed, and the present programs in applied research, and some potential areas of future work are discussed

  15. Future neutrino experiments

    CERN Document Server

    Di Lella, L

    2001-01-01

    Future experiments to search for neutrino oscillations using neutrinos from the Sun, from reactors and accelerators are reviewed. Possible long-term developments based on neutrino factories are also described. (29 refs).

  16. Factorial study of rain garden design for nitrogen removal

    Science.gov (United States)

    Abstract Nitrate (〖NO〗_3^--N ) removal studies in bioretention systems showed great variability in removal rates and in some cases 〖NO〗_3^--N was exported. A 3-way factorial design (2 x 2 x 4) was devised for eight outdoor un-vegetated rain gardens to evaluate the effects of ...

  17. Two ways factorial design for round robin test of anemometers

    International Nuclear Information System (INIS)

    Cuerva, A.

    1998-01-01

    This work presents a way to carry out an inter-comparison between different cup anemometers that are tested in different wind tunnels. The method applied is known as Factorial design and allows determining the influence in the test of different factors in this case the anemometer itself and the wind tunnel where it is tested. (Author) 4 refs

  18. Two Ways Factorial Design for round robin test of anemometers

    Energy Technology Data Exchange (ETDEWEB)

    Cuerva, A.

    1998-07-01

    This work presents a way to carry out an inter-comparison between different cup anemometers that are tested in different wind tunnels. The method applied is known as Factorial design and allows determining the influence in the test of different factors in this case the anemometer itself and the wind tunnel where it is tested. (Author) 4 refs.

  19. Bioretention Systems: Partial Factorial Designs for Nitrate Removal

    Science.gov (United States)

    Changes in nutrient loadings are monitored by introducing captured stormwater runoff into eight outdoor rain gardens at EPA’s Urban Water Research Facility in Edison, New Jersey scaled for residential and urban landscapes. The partial factorial design includes non-vegetated meso...

  20. KEKB B-factory design report

    International Nuclear Information System (INIS)

    1995-08-01

    KEKB is an asymmetric electron-positron collider at 8 x 3.5 GeV which aims at providing electron-positron collision at the center of mass energy of 10.58 GeV. Its mission is to support high energy physics research programs on CP violation and other topics in B-meson decay. Its luminosity goal is 10 34 /cm 2 s. As the construction of the KEKB was approved as a five-year project by the Japanese government, it was begun formally in April, 1994. The low energy ring LER for positrons at 3.5 GeV and the high energy ring HER for electrons at 8 GeV will be built side by side in the existing TRISTAN tunnel with 3 km circumference, and the maximum use of the infrastructure of TRISTAN will be made. The KEKB has only one interaction point in the Tsukuba experimental hall, and the BELLE detector will be installed in this interaction region. The layout of the two rings is explained. In this report, the basic design, hardware systems, the construction schedule, physics requirement, machine parameters, beam-beam interaction, RF parameters, impedance and collective effects, lattice design, interaction region, RF system, magnet system, vacuum system, beam instrumentation, injection and accelerator control system are described. (K.I.)

  1. KEKB B-factory design report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-08-01

    KEKB is an asymmetric electron-positron collider at 8 x 3.5 GeV which aims at providing electron-positron collision at the center of mass energy of 10.58 GeV. Its mission is to support high energy physics research programs on CP violation and other topics in B-meson decay. Its luminosity goal is 10{sup 34}/cm{sup 2}s. As the construction of the KEKB was approved as a five-year project by the Japanese government, it was begun formally in April, 1994. The low energy ring LER for positrons at 3.5 GeV and the high energy ring HER for electrons at 8 GeV will be built side by side in the existing TRISTAN tunnel with 3 km circumference, and the maximum use of the infrastructure of TRISTAN will be made. The KEKB has only one interaction point in the Tsukuba experimental hall, and the BELLE detector will be installed in this interaction region. The layout of the two rings is explained. In this report, the basic design, hardware systems, the construction schedule, physics requirement, machine parameters, beam-beam interaction, RF parameters, impedance and collective effects, lattice design, interaction region, RF system, magnet system, vacuum system, beam instrumentation, injection and accelerator control system are described. (K.I.).

  2. Design and manufacture NCS instruments for cement factories

    International Nuclear Information System (INIS)

    Nguyen Thanh Tuy; Nguyen Tien Dung; Dang Nguyet Anh; Nguyen Phuc; Khuong Thanh Tuan; Luong Duc Long; Pham Trong Quyen

    2003-01-01

    The ministry project 'Design and manufacture some of NCS instruments for cement factories' is a part of instrumentation for cement production in Vietnam. The objectives of the project include: 1/Design and manufacture the automatic control system for cement raw material mixing, connected to components X-ray analyzer through serial port of PC; 2/Design and manufacture the automatic discharge control system using gamma rays. The instruments, made by the project , for controlling the conveyor belt weighing machine can be easily improved for various types of conveyor belt weighing machines. Their mobility and software equipped can be adapted for requirement of modern cement production technology. The instruments are operating well in some cement factories and they are helping in quality control. (NHA)

  3. Ambiguities of theoretical parameters and CP or T violation in neutrino factories

    International Nuclear Information System (INIS)

    Koike, Masafumi; Ota, Toshihiko; Sato, Joe

    2002-01-01

    We study the sensitivity to the CP- or T-violation search in the presence of ambiguities of the theoretical parameters. Three generations of neutrinos are considered. The parameters whose ambiguities are considered are the differences of the squared masses, the mixing angles, and the density of matter. We first consider the statistics that are sensitive to the genuine CP-violation effect originating from the imaginary coupling. No ambiguity of the parameters is considered in this part. It is argued that the widely adopted usual statistics are not necessarily sensitive to the genuine CP-violation effect. Two statistics that are sensitive to the imaginary coupling are proposed. The qualitative difference between these statistics and the usual ones are discussed. Next we proceed to the case where the ambiguity of the parameters is present. The sensitivity of the CP-violation search is greatly spoiled when the baseline length is longer than about one thousand kilometers, which turns out to be due to the ambiguity of the matter effect. Thus the CP-violation search by use of CP conjugate channels turns out to require a low energy neutrino and short baseline length. It is also shown that such a loss of sensitivity is avoided by using T-conjugate oscillation channels

  4. Systems analysis and futuristic designs of advanced biofuel factory concepts.

    Energy Technology Data Exchange (ETDEWEB)

    Chianelli, Russ; Leathers, James; Thoma, Steven George; Celina, Mathias C.; Gupta, Vipin P.

    2007-10-01

    The U.S. is addicted to petroleum--a dependency that periodically shocks the economy, compromises national security, and adversely affects the environment. If liquid fuels remain the main energy source for U.S. transportation for the foreseeable future, the system solution is the production of new liquid fuels that can directly displace diesel and gasoline. This study focuses on advanced concepts for biofuel factory production, describing three design concepts: biopetroleum, biodiesel, and higher alcohols. A general schematic is illustrated for each concept with technical description and analysis for each factory design. Looking beyond current biofuel pursuits by industry, this study explores unconventional feedstocks (e.g., extremophiles), out-of-favor reaction processes (e.g., radiation-induced catalytic cracking), and production of new fuel sources traditionally deemed undesirable (e.g., fusel oils). These concepts lay the foundation and path for future basic science and applied engineering to displace petroleum as a transportation energy source for good.

  5. RF system design for the PEP-II B Factory

    International Nuclear Information System (INIS)

    Schwarz, H.; Rimmer, R.

    1994-06-01

    The paper presents an overview of the design of the RF system for the PEP-II B Factory. An RF station consists of either two or four single-cell cavities driven by a 1.2 MW klystron through a waveguide distribution network. A variety of feedback loops stabilize the RF and its interaction with the beam. System parameters and all the relevant parameters of klystron and cavities are given

  6. Physics at the front-end of a neutrino factory a quantitative appraisal

    CERN Document Server

    Mangano, Michelangelo L.; Anselmino, M.; Ball, R.D.; Boglione, Mariaelena; D'Alesio, U.; Davidson, S.; Lellis, De; Ellis, John R.; Forte, S.; Gambino, P.; Gehrmann, T.; Kataev, A.L.; Kotzinian, A.; Kulagin, Sergey A.; Lehmann-Dronke, B.; Migliozzi, P.; Murgia, F.; Ridolfi, G.

    2004-01-01

    We present a quantitative appraisal of the physics potential for neutrino experiments at the front-end of a muon storage ring. We estimate the forseeable accuracy in the determination of several interesting observables, and explore the consequences of these measurements. We discuss the extraction of individual quark and antiquark densities from polarized and unpolarized deep-inelastic scattering. In particular we study the implications for the undertanding of the nucleon spin structure. We assess the determination of alpha_s from scaling violation of structure functions, and from sum rules, and the determination of sin^2(theta_W) from elastic nu-e and deep-inelastic nu-p scattering. We then consider the production of charmed hadrons, and the measurement of their absolute branching ratios. We study the polarization of Lambda baryons produced in the current and target fragmentation regions. Finally, we discuss the sensitivity to physics beyond the Standard Model.

  7. THERMODYNAMIC INTERACTION OF THE PRIMARY PROTON BEAM WITH A MERCURY JET TARGET AT A NEUTRINO FACTORY SOURCE

    International Nuclear Information System (INIS)

    SIMOS, N.; LUDEWIG, H.; KIRK, H.; THIEBERGER, P.; MCDONALD, K.

    2001-01-01

    This paper addresses the thermodynamic interaction of an intense proton beam with the proposed mercury jet target at a neutrino factory or muon collider source, and the consequences of the generated pressure waves on the target integrity. Specifically, a 24 GeV proton beam with approximately 1.6e13 protons per pulse and a pulse length of 2 nanosec will interact with a 1 cm diameter mercury jet within a 20 Tesla magnetic field. In one option, a train of six such proton pulses is to be delivered on target within 2 microsec, in which case the state of the mercury jet following the interaction with each pulse is critical. Using the equation of state for mercury from the SESAME library, in combination with the energy deposition rates calculated the by the hadron interaction code MARS, the induced 3-D pressure field in the target is estimated. The consequent pressure wave propagation and attenuation in the mercury jet is calculated using an ANSYS code transient analysis, and the state of the mercury jet at the time of arrival of the subsequent pulse is assessed. The amplitude of the pressure wave reaching the nozzle that ejects the mercury jet into the magnetic field is estimated and the potential for mechanical damage is addressed

  8. Design Learning of Teaching Factory in Mechanical Engineering

    Science.gov (United States)

    Putra, R. C.; Kusumah, I. H.; Komaro, M.; Rahayu, Y.; Asfiyanur, E. P.

    2018-02-01

    The industrial world that is the target of the process and learning outcomes of vocational high school (SMK) has its own character and nuance. Therefore, vocational education institutions in the learning process should be able to make the appropriate learning approach and in accordance with the industrial world. One approach to learning that is based on production and learning in the world of work is by industry-based learning or known as Teaching Factory, where in this model apply learning that involves direct students in goods or service activities are expected to have the quality so it is worth selling and accepted by consumers. The method used is descriptive approach. The purpose of this research is to get the design of the teaching factory based on the competency requirements of the graduates of the spouse industry, especially in the engineering department. The results of this study is expected to be one of the choice of model factory teaching in the field of machinery engineering in accordance with the products and competencies of the graduates that the industry needs.

  9. Factorial Design Approach in Proportioning Prestressed Self-Compacting Concrete.

    Science.gov (United States)

    Long, Wu-Jian; Khayat, Kamal Henri; Lemieux, Guillaume; Xing, Feng; Wang, Wei-Lun

    2015-03-13

    In order to model the effect of mixture parameters and material properties on the hardened properties of, prestressed self-compacting concrete (SCC), and also to investigate the extensions of the statistical models, a factorial design was employed to identify the relative significance of these primary parameters and their interactions in terms of the mechanical and visco-elastic properties of SCC. In addition to the 16 fractional factorial mixtures evaluated in the modeled region of -1 to +1, eight axial mixtures were prepared at extreme values of -2 and +2 with the other variables maintained at the central points. Four replicate central mixtures were also evaluated. The effects of five mixture parameters, including binder type, binder content, dosage of viscosity-modifying admixture (VMA), water-cementitious material ratio (w/cm), and sand-to-total aggregate ratio (S/A) on compressive strength, modulus of elasticity, as well as autogenous and drying shrinkage are discussed. The applications of the models to better understand trade-offs between mixture parameters and carry out comparisons among various responses are also highlighted. A logical design approach would be to use the existing model to predict the optimal design, and then run selected tests to quantify the influence of the new binder on the model.

  10. Long-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE): Conceptual Design Report. Volume 1: The LBNF and DUNE Projects

    Energy Technology Data Exchange (ETDEWEB)

    Acciarri, R. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); et al.

    2016-01-22

    This document presents the Conceptual Design Report (CDR) put forward by an international neutrino community to pursue the Deep Underground Neutrino Experiment at the Long-Baseline Neutrino Facility (LBNF/DUNE), a groundbreaking science experiment for long-baseline neutrino oscillation studies and for neutrino astrophysics and nucleon decay searches. The DUNE far detector will be a very large modular liquid argon time-projection chamber (LArTPC) located deep underground, coupled to the LBNF multi-megawatt wide-band neutrino beam. DUNE will also have a high-resolution and high-precision near detector.

  11. Long-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE) Conceptual Design Report Volume 1: The LBNF and DUNE Projects

    CERN Document Server

    Acciarri, R.; Adamowski, M.; Adams, C.; Adamson, P.; Adhikari, S.; Ahmad, Z.; Albright, C.H.; Alion, T.; Amador, E.; Anderson, J.; Anderson, K.; Andreopoulos, C.; Andrews, M.; Andrews, R.; Anghel, I.; Anjos, J. d.; Ankowski, A.; Antonello, M.; Aranda Fernandez, A.; Ariga, A.; Ariga, T.; Aristizabal, D.; Arrieta-Diaz, E.; Aryal, K.; Asaadi, J.; Asner, D.; Athar, M.S.; Auger, M.; Aurisano, A.; Aushev, V.; Autiero, D.; Avila, M.; Back, J.J.; Bai, X.; Baibussinov, B.; Baird, M.; Balantekin, B.; Baller, B.; Ballett, P.; Bambah, B.; Bansal, M.; Bansal, S.; Barker, G.J.; Barletta, W.A.; Barr, G.; Barros, N.; Bartosz, B.; Bartoszek, L.; Bashyal, A.; Bass, M.; Bay, F.; Beacom, J.; Behera, B.R.; Bellettini, G.; Bellini, V.; Beltramello, O.; Benekos, N.; Benetti, P.A.; Bercellie, A.; Bergevin, M.; Berman, E.; Berns, H.; Bernstein, R.; Bertolucci, S.; Bhandari, B.; Bhatnagar, V.; Bhuyan, B.; Bian, J.; Biery, K.; Bishai, M.; Blackburn, T.; Blake, A.; Blaszczyk, F. d. M.; Blaufuss, E.; Bleakley, B.; Blucher, E.; Bocean, V.; Boffelli, F.; Boissevain, J.; Bolognesi, S.; Bolton, T.; Bonesini, M.; Boone, T.; Booth, C.; Bordoni, S.; Borysova, M.; Bourguille, B.; Boyd, S.B.; Brailsford, D.; Brandt, A.; Bremer, J.; Brice, S.; Bromberg, C.; Brooijmans, G.; Brown, G.; Brown, R.; Brunetti, G.; Bu, X.; Buchanan, N.; Budd, H.; Bugg, B.; Calafiura, P.; Calligarich, E.; Calvo, E.; Camilleri, L.; Campanelli, M.; Cantini, C.; Carls, B.; Carr, R.; Cascella, M.; Castromonte, C.; Mur, E.Catano; Cavanna, F.; Centro, S.; Cervera Villanueva, A.; Chalifour, M.; Chandratre, V.B.; Chatterjee, A.; Chattopadhyay, S.; Chattopadhyay, S.; Chaussard, L.; Chembra, S.; Chen, H.; Chen, K.; Chen, M.; Cherdack, D.; Chi, C.; Childress, S.; Choubey, S.; Choudhary, B.C.; Christodoulou, G.; Christofferson, C.; Church, E.; Cianci, D.; Cline, D.; Coan, T.; Cocco, A.; Coelho, J.; Cole, P.; Collin, G.; Conrad, J.M.; Convery, M.; Corey, R.; Corwin, L.; Cranshaw, J.; Crivelli, P.; Cronin-Hennessy, D.; Curioni, A.; Cushing, J.; Adams, D.L.; Dale, D.; Das, S.R.; Davenne, T.; Davies, G.S.; Davies, J.; Dawson, J.; De, K.; de Gouvea, A.; de Jong, J.K.; de Jong, P.; De Lurgio, P.; Decowski, M.; Delbart, A.; Densham, C.; Dharmapalan, R.; Dhingra, N.; Di Luise, S.; Diamantopoulou, M.; Diaz, J.S.; Diaz Bautista, G.; Diwan, M.; Djurcic, Z.; Dolph, J.; Drake, G.; Duchesneau, D.; Duvernois, M.; Duyang, H.; Dwyer, D.A.; Dye, S.; Dytman, S.; Eberly, B.; Edgecock, R.; Edmunds, D.; Elliott, S.; Elnimr, M.; Emery, S.; Endress, E.; Eno, S.; Ereditato, A.; Escobar, C.O.; Evans, J.; Falcone, A.; Falk, L.; Farbin, A.; Farnese, C.; Farzan, Y.; Fava, A.; Favilli, L.; Felde, J.; Felix, J.; Fernandes, S.; Fields, L.; Finch, A.; Fitton, M.; Fleming, B.; Forest, T.; Fowler, J.; Fox, W.; Fried, J.; Friedland, A.; Fuess, S.; Fujikawa, B.; Gago, A.; Gallagher, H.; Galymov, S.; Gamble, T.; Gandhi, R.; Garcia-Gamez, D.; Gardiner, S.; Garvey, G.; Gehman, V.M.; Gendotti, A.; Geronimo, G. d.; Ghag, C.; Ghoshal, P.; Gibin, D.; Gil-Botella, I.; Gill, R.; Girardelli, D.; Giri, A.; Glavin, S.; Goeldi, D.; Golapinni, S.; Gold, M.; Gomes, R.A.; Gomez Cadenas, J.J.; Goodman, M.C.; Gorbunov, D.; Goswami, S.; Graf, N.; Graf, N.; Graham, M.; Gramelini, E.; Gran, R.; Grant, C.; Grant, N.; Greco, V.; Greenlee, H.; Greenler, L.; Greenley, C.; Groh, M.; Grullon, S.; Grundy, T.; Grzelak, K.; Guardincerri, E.; Guarino, V.; Guarnaccia, E.; Guedes, G.P.; Guenette, R.; Guglielmi, A.; Habig, A.T.; Hackenburg, R.W.; Hackenburg, A.; Hadavand, H.; Haenni, R.; Hahn, A.; Haigh, M.D.; Haines, T.; Hamernik, T.; Handler, T.; Hans, S.; Harris, D.; Hartnell, J.; Hasegawa, T.; Hatcher, R.; Hatzikoutelis, A.; Hays, S.; Hazen, E.; Headley, M.; Heavey, A.; Heeger, K.; Heise, J.; Hennessy, K.; Hewes, J.; Higuera, A.; Hill, T.; Himmel, A.; Hogan, M.; Holanda, P.; Holin, A.; Honey, W.; Horikawa, S.; Horton-Smith, G.; Howard, B.; Howell, J.; Hurh, P.; Huston, J.; Hylen, J.; Imlay, R.; Insler, J.; Introzzi, G.; Ioanisyan, D.; Ioannisian, A.; Iwamoto, K.; Izmaylov, A.; Jackson, C.; Jaffe, D.E.; James, C.; James, E.; Jediny, F.; Jen, C.; Jhingan, A.; Jimenez, S.; Jo, J.H.; Johnson, M.; Johnson, R.; Johnstone, J.; Jones, B.J.; Joshi, J.; Jostlein, H.; Jung, C.K.; Junk, T.; Kaboth, A.; Kadel, R.; Kafka, T.; Kalousis, L.; Kamyshkov, Y.; Karagiorgi, G.; Karasavvas, D.; Karyotakis, Y.; Kaur, A.; Kaur, P.; Kayser, B.; Kazaryan, N.; Kearns, E.; Keener, P.; Kemboi, S.; Kemp, E.; Kettell, S.H.; Khabibullin, M.; Khandaker, M.; Khotjantsev, A.; Kirby, B.; Kirby, M.; Klein, J.; Kobilarcik, T.; Kohn, S.; Koizumi, G.; Kopylov, A.; Kordosky, M.; Kormos, L.; Kose, U.; Kostelecky, A.; Kramer, M.; Kreslo, I.; Kriske, R.; Kropp, W.; Kudenko, Y.; Kudryavtsev, V.A.; Kulagin, S.; Kumar, A.; Kumar, G.; Kumar, J.; Kumar, L.; Kutter, T.; Laminack, A.; Lande, K.; Lane, C.; Lang, K.; Lanni, F.; Learned, J.; Lebrun, P.; Lee, D.; Lee, H.; Lee, K.; Lee, W.M.; Leigui de Oliveira, M.A.; Li, Q.; Li, S.; Li, S.; Li, X.; Li, Y.; Li, Z.; Libo, J.; Lin, C.S.; Lin, S.; Ling, J.; Link, J.; Liptak, Z.; Lissauer, D.; Littenberg, L.; Littlejohn, B.; Liu, Q.; Liu, T.; Lockwitz, S.; Lockyer, N.; Loew, T.; Lokajicek, M.; Long, K.; Lopes, M.D.L.; Lopez, J.P.; Losecco, J.; Louis, W.; Lowery, J.; Luethi, M.; Luk, K.; Lundberg, B.; Lundin, T.; Luo, X.; Lux, T.; Lykken, J.; Machado, A.A.; Macier, J.R.; Magill, S.; Mahler, G.; Mahn, K.; Malek, M.; Malhotra, S.; Malon, D.; Mammoliti, F.; Mancina, S.; Mandal, S.K.; Mandodi, S.; Manly, S.L.; Mann, A.; Marchionni, A.; Marciano, W.; Mariani, C.; Maricic, J.; Marino, A.; Marshak, M.; Marshall, C.; Marshall, J.; Marteau, J.; Martin-Albo, J.; Martinez, D.; Matsuno, S.; Matthews, J.; Mauger, C.; Mavrokoridis, K.; Mayilyan, D.; Mazzucato, E.; McCauley, N.; McCluskey, E.; McConkey, N.; McDonald, K.; McFarland, K.S.; McGowan, A.M.; McGrew, C.; McKeown, R.; McNulty, D.; McTaggart, R.; Mefodiev, A.; Mehrian, M.; Mehta, P.; Mei, D.; Mena, O.; Menary, S.; Mendez, H.; Menegolli, A.; Meng, G.; Meng, Y.; Mertins, D.; Merritt, H.; Messier, M.; Metcalf, W.; Mewes, M.; Meyer, H.; Miao, T.; Milincic, R.; Miller, W.; Mills, G.; Mineev, O.; Miranda, O.; Mishra, C.S.; Mishra, S.R.; Mitrica, B.; Mladenov, D.; Mocioiu, I.; Mohanta, R.; Mokhov, N.; Montanari, C.; Montanari, D.; Moon, J.; Mooney, M.; Moore, C.; Morfin, J.; Morgan, B.; Morris, C.; Morse, W.; Moss, Z.; Mossey, C.; Moura, C.A.; Mousseau, J.; Mualem, L.; Muether, M.; Mufson, S.; Murphy, S.; Musser, J.; Musser, R.; Nakajima, Y.; Naples, D.; Napolitano, J.; Navarro, J.; Navas, D.; Nelson, J.; Nessi, M.; Newcomer, M.; Ng, Y.; Nichol, R.; Nicholls, T.C.; Nikolics, K.; Niner, E.; Norris, B.; Noto, F.; Novakova, P.; Novella, P.; Nowak, J.; Nunes, M.S.; O'Keeffe, H.; Oldeman, R.; Oliveira, R.; Olson, T.; Onishchuk, Y.; Osta, J.; Ovsjannikova, T.; Page, B.; Pakvasa, S.; Pal, S.; Palamara, O.; Palazzo, A.; Paley, J.; Palomares, C.; Pantic, E.; Paolone, V.; Papadimitriou, V.; Park, J.; Parke, S.; Parsa, Z.; Pascoli, S.; Patterson, R.; Patton, S.; Patzak, T.; Paulos, B.; Paulucci, L.; Pavlovic, Z.; Pawloski, G.; Peeters, S.; Pennacchio, E.; Perch, A.; Perdue, G.N.; Periale, L.; Perkin, J.D.; Pessard, H.; Petrillo, G.; Petti, R.; Petukhov, A.; Pietropaolo, F.; Plunkett, R.; Pordes, S.; Potekhin, M.; Potenza, R.; Potukuchi, B.; Poudyal, N.; Prokofiev, O.; Pruthi, N.; Przewlocki, P.; Pushka, D.; Qian, X.; Raaf, J.L.; Raboanary, R.; Radeka, V.; Radovic, A.; Raffelt, G.; Rakhno, I.; Rakotondramanana, H.T.; Rakotondravohitra, L.; Ramachers, Y.A.; Rameika, R.; Ramsey, J.; Rappoldi, A.; Raselli, G.; Ratoff, P.; Rebel, B.; Regenfus, C.; Reichenbacher, J.; Reitzner, D.; Remoto, A.; Renshaw, A.; Rescia, S.; Richardson, M.; Rielage, K.; Riesselmann, K.; Robinson, M.; Rochester, L.; Rodrigues, O.B.; Rodrigues, P.; Roe, B.; Rosen, M.; Roser, R.M.; Ross-Lonergan, M.; Rossella, M.; Rubbia, A.; Rubbia, C.; Rucinski, R.; von Rohr, C.Rudolph; Russell, B.; Ruterbories, D.; Saakyan, R.; Sahu, N.; Sala, P.; Samios, N.; Sanchez, F.; Sanchez, M.; Sands, B.; Santana, S.; Santorelli, R.; Santucci, G.; Saoulidou, N.; Scaramelli, A.; Schellman, H.; Schlabach, P.; Schmitt, R.; Schmitz, D.; Schneps, J.; Scholberg, K.; Schukraft, A.; Schwehr, J.; Segreto, E.; Seibert, S.; Sepulveda-Quiroz, J.A.; Sergiampietri, F.; Sexton-Kennedy, L.; Sgalaberna, D.; Shaevitz, M.; Shahi, J.; Shahsavarani, S.; Shanahan, P.; Shankar, S.U.; Sharma, R.; Sharma, R.K.; Shaw, T.; Shrock, R.; Shyrma, I.; Simos, N.; Sinev, G.; Singh, I.; Singh, J.; Singh, J.; Singh, V.; Sinnis, G.; Sippach, W.; Smargianaki, D.; Smy, M.; Snider, E.; Snopok, P.; Sobczyk, J.; Sobel, H.; Soderberg, M.; Solomey, N.; Sondheim, W.; Sorel, M.; Sousa, A.; Soustruznik, K.; Spitz, J.; Spooner, N.J.; Stancari, M.; Stancu, I.; Stefan, D.; Steiner, H.M.; Stewart, J.; Stock, J.; Stoica, S.; Stone, J.; Strait, J.; Strait, M.; Strauss, T.; Striganov, S.; Sulej, R.; Sullivan, G.; Sun, Y.; Suter, L.; Sutera, C.M.; Svoboda, R.; Szczerbinska, B.; Szelc, A.; Soldner-Rembold, S.; Talaga, R.; Tamsett, M.; Tariq, S.; Tatar, E.; Tayloe, R.; Taylor, C.; Taylor, D.; Terao, K.; Thiesse, M.; Thomas, J.; Thompson, L.F.; Thomson, M.; Thorn, C.; Thorpe, M.; Tian, X.; Tiedt, D.; Timm, S.C.; Tonazzo, A.; Tope, T.; Topkar, A.; Torres, F.R.; Torti, M.; Tortola, M.; Tortorici, F.; Toups, M.; Touramanis, C.; Tripathi, M.; Tropin, I.; Tsai, Y.; Tsang, K.V.; Tsenov, R.; Tufanli, S.; Tull, C.; Turner, J.; Tzanov, M.; Tziaferi, E.; Uchida, Y.; Urheim, J.; Usher, T.; Vagins, M.; Vahle, P.; Valdiviesso, G.A.; Valerio, L.; Vallari, Z.; Valle, J.; Van Berg, R.; Van de Water, R.; Van Gemmeren, P.; Varanini, F.; Varner, G.; Vasseur, G.; Vaziri, K.; Velev, G.; Ventura, S.; Verdugo, A.; Viant, T.; Vieira, T.V.; Vignoli, C.; Vilela, C.; Viren, B.; Vrba, T.; Wachala, T.; Wahl, D.; Wallbank, M.; Walsh, N.; Wang, B.; Wang, H.; Wang, L.; Wang, T.; Warburton, T.K.; Warner, D.; Wascko, M.; Waters, D.; Watson, T.B.; Weber, A.; Weber, M.; Wei, W.; Weinstein, A.; Wells, D.; Wenman, D.; Wetstein, M.; White, A.; Whitehead, L.; Whittington, D.; Wilking, M.; Willhite, J.; Wilson, P.; Wilson, R.J.; Winslow, L.; Wittich, P.; Wojcicki, S.; Wong, H.H.; Wood, K.; Worcester, E.; Worcester, M.; Wu, S.; Xin, T.; Yanagisawa, C.; Yang, S.; Yang, T.; Yarritu, K.; Ye, J.; Yeh, M.; Yershov, N.; Yonehara, K.; Yu, B.; Yu, J.; Zalesak, J.; Zalewska, A.; Zamorano, B.; Zang, L.; Zani, A.; Zani, A.; Zavala, G.; Zeller, G.; Zhang, C.; Zhang, C.; Zimmerman, E.D.; Zito, M.; Zwaska, R.

    2016-01-01

    This document presents the Conceptual Design Report (CDR) put forward by an international neutrino community to pursue the Deep Underground Neutrino Experiment at the Long-Baseline Neutrino Facility (LBNF/DUNE), a groundbreaking science experiment for long-baseline neutrino oscillation studies and for neutrino astrophysics and nucleon decay searches. The DUNE far detector will be a very large modular liquid argon time-projection chamber (LArTPC) located deep underground, coupled to the LBNF multi-megawatt wide-band neutrino beam. DUNE will also have a high-resolution and high-precision near detector.

  12. Optimization of minoxidil microemulsions using fractional factorial design approach.

    Science.gov (United States)

    Jaipakdee, Napaphak; Limpongsa, Ekapol; Pongjanyakul, Thaned

    2016-01-01

    The objective of this study was to apply fractional factorial and multi-response optimization designs using desirability function approach for developing topical microemulsions. Minoxidil (MX) was used as a model drug. Limonene was used as an oil phase. Based on solubility, Tween 20 and caprylocaproyl polyoxyl-8 glycerides were selected as surfactants, propylene glycol and ethanol were selected as co-solvent in aqueous phase. Experiments were performed according to a two-level fractional factorial design to evaluate the effects of independent variables: Tween 20 concentration in surfactant system (X1), surfactant concentration (X2), ethanol concentration in co-solvent system (X3), limonene concentration (X4) on MX solubility (Y1), permeation flux (Y2), lag time (Y3), deposition (Y4) of MX microemulsions. It was found that Y1 increased with increasing X3 and decreasing X2, X4; whereas Y2 increased with decreasing X1, X2 and increasing X3. While Y3 was not affected by these variables, Y4 increased with decreasing X1, X2. Three regression equations were obtained and calculated for predicted values of responses Y1, Y2 and Y4. The predicted values matched experimental values reasonably well with high determination coefficient. By using optimal desirability function, optimized microemulsion demonstrating the highest MX solubility, permeation flux and skin deposition was confirmed as low level of X1, X2 and X4 but high level of X3.

  13. Magnet design studies for the TRIUMF KAON factory proposal

    International Nuclear Information System (INIS)

    Otter, A.J.; Ellstrom, L.; Haddock, C.; Harold, M.; Reeve, P.; Sasaki, H.; Schwandt, P.

    1989-10-01

    TRIUMF is engaged on a one year Project Definition Study of its KAON factory proposal. This proposal calls for a total of 1800 magnets to be installed in three storage rings, two synchrotrons, beam transfer lines and experimental facilities to increase the present beam from 200 μA at 500 MeV to 100 μA at 30 GeV. The paper discusses the current design status concentrating on the ac booster synchrotron ring magnets which will be driven by biased dc current modulated at 50 Hz. Methods of estimating the core losses for this excitation, the coil eddy current losses and design and fabrication features of prototypes will be presented

  14. Design Studies for a 1036 SuperB-Factory

    International Nuclear Information System (INIS)

    Seeman, J

    2003-01-01

    A Super B Factory, an asymmetric e + e - collider with a luminosity of 10 36 cm -2 s -1 , can provide a sensitive probe of new physics in the flavor sector of the Standard Model. The success of PEP-II and KEKB in producing unprecedented luminosity with unprecedented short commissioning time has taught us about the accelerator physics of asymmetric e + e - colliders in a new parameter regime. It appears to be possible to build on this success to advance the state of the accelerator art by building a collider at a luminosity approaching 10 36 cm -2 s -1 . Such a collider would produce an integrated luminosity of 10,000 fb -1 (10 ab -1 ) in a running year. Design studies are underway to arrive at a complete parameter set based on a collider in the PEP-II tunnel but with an upgraded RF system (perhaps a higher frequency) and an upgraded interaction region [1-6

  15. Optimization of MCM-48 synthesis using factorial design

    Energy Technology Data Exchange (ETDEWEB)

    Nascimento, A.R. do; Medeiros, R.L.B. de A.; Melo, M. A. de F.; Melo, D.M. de A. [Universitdade Federal do Rio Grande do Norte (UFRN), Natal (Brazil); Souza, M.J.B. de, E-mail: ale3ufs@yahoo.com.br [Universidade Federal de Sergipe (UFS), Sao Cristovao (Brazil)

    2016-10-15

    MCM-48 mesoporous materials were hydrothermally synthesized according to the 2{sup 2} factorial design by varying the crystallization time and temperature of the synthesis gel, and characterized by means of X-ray diffraction analysis and adsorption of N{sub 2} . In the crystallization temperature and time conditions used, specific areas between 924 to 1102 m{sup 2}.g{sup -1}, pore volumes between 0.015 to 0.087 cm{sup 3}.g{sup -1} and pore diameters between 3.2 to 4.0 nm were obtained. It was observed that for the syntheses performed at high temperature, the crystallization time should be reduced so that the material structure is formed. (author)

  16. Accelerator design of the KEK B-Factory

    International Nuclear Information System (INIS)

    Kurokawa, Shin-ichi; Satoh, Kotaro; Kikutani, Eiji

    1991-03-01

    A design study has been made for the KEK B-Factory, an accelerator complex dedicated to the detection of the CP-violation effect of B-mesons. It is an asymmetric two-ring electron-positron collider of 3.5x8 GeV within a new tunnel measuring 1273 m circumference. The design peak luminosity is to be 10 34 cm -2 s -1 , which will be realized in two steps. The luminosity is to be 2 x 10 33 cm -2 s -1 with a head-on collision scheme in the first step; it is then increased to a final value of 10 34 cm -2 s -1 with a finite-angle crossing scheme. This document comprises two parts; the first part presents an overview of the design; the second part is a collection of papers giving detailed descriptions of various subjects. Stress is put on the design of the first step; the second step is mentioned when necessary. (author)

  17. Long-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE): Conceptual Design Report. Volume 3: Long-Baseline Neutrino Facility for DUNE

    Energy Technology Data Exchange (ETDEWEB)

    Strait, James [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States); McCluskey, Elaine [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States); Lundin, Tracy [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States); Willhite, Joshua [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States); Hamernik, Thomas [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States); Papadimitriou, Vaia [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States); Marchionni, Alberto [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States); Kim, Min Jeong [National Inst. of Nuclear Physics (INFN), Frascati (Italy). National Lab. of Frascati (INFN-LNF); Nessi, Marzio [Univ. of Geneva (Switzerland); Montanari, David [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States); Heavey, Anne [Fermi National Accelerator Laboratory (FNAL), Batavia, IL (United States)

    2016-01-21

    This volume of the LBNF/DUNE Conceptual Design Report covers the Long-Baseline Neutrino Facility for DUNE and describes the LBNF Project, which includes design and construction of the beamline at Fermilab, the conventional facilities at both Fermilab and SURF, and the cryostat and cryogenics infrastructure required for the DUNE far detector.

  18. PEP-II: An asymmetric B factory. Conceptual design report

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    In this report, the authors have described an updated conceptual design for the high-luminosity Asymmetric B Factory (PEP-II) to be built in the PEP tunnel culmination of more than four years of effort aimed at the design and construction of an asymmetric e{sub +}e{sub {minus}} collider capable of achieving a luminosity of L = 3 {times} 10{sup 33} cm{sup {minus}2} s{sup {minus}1}. All aspects of the conceptual design were scrutinized in March 1991 by a DOE technical review committee chaired by Dr. L. Edward Temple. The design was deemed feasible and capable of achieving its physics goals. Furthermore, the cost estimate, schedule, and management plan for the project were fully endorsed by the committee. This updated conceptual design report captures the technical progress since the March 1991 review and reflects the lower cost estimate corresponding to the improved design. Although the PEP-II design has continued to evolve, no technical scope changes have been made that invalidate the conclusion of the DOE review. The configuration adopted utilizes two storage rings, an electron ring operating at 9 GeV and a positron ring at 3.1 GeV, each with a circumference of 2200 m. The high-energy ring is an upgrade of the PEP storage ring at SLAC; all PEP magnets and most power supplies will be reused. The upgrade consists primarily of replacing the PEP vacuum chamber and RF system with newly designed versions optimized for the high-current environment of PEP-II. The low-energy ring will be newly constructed and will be situated atop the high-energy ring in the PEP tunnel. Utilities already installed in the PEP tunnel are largely sufficient to operate the two PEP-II storage rings.

  19. Photon Detection System Designs for the Deep Underground Neutrino Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Whittington, Denver [Indiana U.

    2015-11-19

    The Deep Underground Neutrino Experiment (DUNE) will be a premier facility for exploring long-standing questions about the boundaries of the standard model. Acting in concert with the liquid argon time projection chambers underpinning the far detector design, the DUNE photon detection system will capture ultraviolet scintillation light in order to provide valuable timing information for event reconstruction. To maximize the active area while maintaining a small photocathode coverage, the experiment will utilize a design based on plastic light guides coated with a wavelength-shifting compound, along with silicon photomultipliers, to collect and record scintillation light from liquid argon. This report presents recent preliminary performance measurements of this baseline design and several alternative designs which promise significant improvements in sensitivity to low-energy interactions.

  20. The CERN neutrino beam to Gran Sasso (NGS). Conceptual technical design

    Energy Technology Data Exchange (ETDEWEB)

    Elsener, K [ed.; Acquistapace, G; Baldy, J L; Ball, A E; Bonnal, P; Buhler-Broglin, M; Carminati, F; Cennini, E; Ereditato, A; Falaleev, V; Faugeras, P; Ferrari, A; Foa, L; Fortuna, G; Genand, R; Grant, A L; Henny, L; Hilaire, A; Huebner, K; Inigo-Golfin, J; Kissler, K H; Lopez-Hernandez, L A; Maugain, J M; Mayoud, M; Migliozzi, P; Missiaen, D; Palladino, V; Papadopoulos, I M; Peraire, S; Pietropaolo, F; Rangod, S; Revol, J P; Roche, J; Sala, P; Sanelli, C; Stevenson, G R; Tomat, B; Tsesmelis, E; Valbuena, R; Vincke, H; Weisse, E; Wilhelmsson, M

    1998-05-19

    The conceptual design of a new neutrino facility at CERN is presented. Starting with 400 GeV/c protons from the Super Proton Synchrotron (SPS), a neutrino beam is produced which is directed towards the underground Gran Sasso Laboratory in Italy, 732 km away from CERN, where large, complex detectors will allow long-baseline experiments searching for neutrino oscillation phenomena to be performed. (orig.)

  1. The CERN neutrino beam to Gran Sasso (NGS). Conceptual technical design

    International Nuclear Information System (INIS)

    Elsener, K.; Acquistapace, G.; Baldy, J.L.; Ball, A.E.; Bonnal, P.; Buhler-Broglin, M.; Carminati, F.; Cennini, E.; Ereditato, A.; Falaleev, V.; Faugeras, P.; Ferrari, A.; Foa, L.; Fortuna, G.; Genand, R.; Grant, A.L.; Henny, L.; Hilaire, A.; Huebner, K.; Inigo-Golfin, J.; Kissler, K.H.; Lopez-Hernandez, L.A.; Maugain, J.M.; Mayoud, M.; Migliozzi, P.; Missiaen, D.; Palladino, V.; Papadopoulos, I.M.; Peraire, S.; Pietropaolo, F.; Rangod, S.; Revol, J.P.; Roche, J.; Sala, P.; Sanelli, C.; Stevenson, G.R.; Tomat, B.; Tsesmelis, E.; Valbuena, R.; Vincke, H.; Weisse, E.; Wilhelmsson, M.

    1998-01-01

    The conceptual design of a new neutrino facility at CERN is presented. Starting with 400 GeV/c protons from the Super Proton Synchrotron (SPS), a neutrino beam is produced which is directed towards the underground Gran Sasso Laboratory in Italy, 732 km away from CERN, where large, complex detectors will allow long-baseline experiments searching for neutrino oscillation phenomena to be performed. (orig.)

  2. Particle physics prospects for the KAON factory

    International Nuclear Information System (INIS)

    Bryman, D.

    1989-05-01

    The Kaon Factory at TRIUMF will produce beams of kaons, antiprotons, neutrinos and other particles with a hundred-fold increase in intensity over existing machines in the 30 GeV region. This will make possible new high precision experiments designed to test current ideas as well as high sensitivity measurements which could potentially reveal new effects. A sample of particle physics experiments involving rare kaon decays, CP and T violation studies, neutrino properties and reactions and light quark spectroscopy which might take advantage of the new opportunities presented by the Kaon Factory is discussed

  3. Beam and experiments summary [neutrino studies

    CERN Document Server

    Blondel, A; Campanelli, M; Cervera-Villanueva, Anselmo; Cline, David B; Collot, J; De Jong, M; Donini, Andrea; Dydak, Friedrich; Edgecock, R; Gavela-Legazpi, Maria Belen; Gómez-Cadenas, J J; González-Garciá, M Concepción; Gruber, P; Harris, D A; Hernández, Pilar; Kuno, Y; Litchfield, P J; McFarland, K; Mena, O; Migliozzi, P; Palladino, Vittorio; Panman, J; Papadopoulos, I M; Para, A; Peña-Garay, C; Pérez, P; Rigolin, Stefano; Romanino, Andrea; Rubbia, André; Strolin, P; Wojcicki, S G

    2000-01-01

    The discovery of neutrino oscillations marks a major milestone in the history of neutrino physics, and opens a new window to the still mysterious origin of masses and flavour mixing. Many current and forthcoming experiments will. Answer open questions; however, a major step forward, up to and possibly including CP violation in the neutrino-mixing matrix, requires the neutrino beams from a neutrino factory. The neutrino factory is a new concept for producing neutrino beams of unprecedented quality in terms of intensity, flavour composition, and precision of the beam parameters. Most importantly, the neutrino factory is the only known way to generate a high- intensity beam of electron neutrinos of high energy. The neutrino beam from a neutrino factory, in particular the electron-neutrino beam, enables the exploration of otherwise inaccessible domains in neutrino oscillation physics by exploiting baselines of planetary dimensions. Suitable detectors pose formidable challenges but seem within reach with only mode...

  4. Industry 4.0 learning factory didactic design parameters for industrial engineering education in South Africa

    OpenAIRE

    Sackey, S. M.; Bester, A.; Adams, D.

    2017-01-01

    To manage the impact of Industry 4.0 on industrial engineering (IE) education curriculum requirements, realistic teaching and learning infrastructure such as a learning factory are required. This paper scans the literature to determine Industry 4.0’s principles and interactions with IE and a learning factory, surveys relevant universities by questionnaire to determine its current status and practices, and formulates didactic design parameters for an Industry 4.0 learning factory to support IE...

  5. Design and analysis of a 1-ton prototype of the Jinping Neutrino Experiment

    International Nuclear Information System (INIS)

    Wang, Zongyi; Wang, Yuanqing; Wang, Zhe; Chen, Shaomin; Du, Xinxi; Zhang, Tianxiong; Guo, Ziyi; Yuan, Huanxin

    2017-01-01

    The Jinping Neutrino Experiment will perform an in-depth research on solar neutrinos and geo-neutrinos. Two structural options (i.e., cylindrical and spherical schemes) are proposed for the Jinping detector based on other successful underground neutrino detectors. Several key factors in the design are also discussed in detail. A 1-ton prototype of the Jinping experiment is proposed based on physics requirements. Subsequently, the structural design, installation procedure, and mechanical analysis of the neutrino detector prototype are discussed. The results show that the maximum Mises stresses on the acrylic vessel, stainless steel truss, and the tank are all lower than the design values of the strengths. The stability requirement of the stainless steel truss in the detector prototype is satisfied. Consequently, the structural scheme for the 1-ton prototype is safe and reliable.

  6. Design and analysis of a 1-ton prototype of the Jinping Neutrino Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Zongyi, E-mail: wangzongyi1990@outlook.com [School of Civil Engineering, Wuhan University, Wuhan 430072 (China); Wang, Yuanqing [Key Laboratory of Civil Engineering Safety and Durability of Education Ministry, Tsinghua University, Beijing 100084 (China); Wang, Zhe; Chen, Shaomin [Department of Engineering Physics, Tsinghua University, Beijing 100084 (China); Du, Xinxi [School of Civil Engineering, Wuhan University, Wuhan 430072 (China); Zhang, Tianxiong [School of Civil Engineering, Tianjin University, Tianjin 300072 (China); Guo, Ziyi [Department of Engineering Physics, Tsinghua University, Beijing 100084 (China); Yuan, Huanxin [School of Civil Engineering, Wuhan University, Wuhan 430072 (China)

    2017-05-21

    The Jinping Neutrino Experiment will perform an in-depth research on solar neutrinos and geo-neutrinos. Two structural options (i.e., cylindrical and spherical schemes) are proposed for the Jinping detector based on other successful underground neutrino detectors. Several key factors in the design are also discussed in detail. A 1-ton prototype of the Jinping experiment is proposed based on physics requirements. Subsequently, the structural design, installation procedure, and mechanical analysis of the neutrino detector prototype are discussed. The results show that the maximum Mises stresses on the acrylic vessel, stainless steel truss, and the tank are all lower than the design values of the strengths. The stability requirement of the stainless steel truss in the detector prototype is satisfied. Consequently, the structural scheme for the 1-ton prototype is safe and reliable.

  7. Batch phenol biodegradation study and application of factorial experimental design

    Directory of Open Access Journals (Sweden)

    A. Hellal

    2010-01-01

    Full Text Available A bacterium, Pseudomonas aeruginosa (ATTC27853, was investigated for its ability to grow and to degrade phenol as solecarbon source, in aerobic batch culture. The parameters which affect the substrate biodegradation such as the adaptation ofbacteria to phenol, the temperature, and the nature of the bacteria were investigated. The results show that for a range oftemperature of 30 to 40°C, the best degradation of phenol for a concentration of 100mg/l was observed at 30°C. The regenerationof the bacterium which allows the reactivation of its enzymatic activity, shows that the degradation of 100 mg/ l ofsubstrate at 30° C required approximately 50 hours with revivified bacteria, while it only starts after 72 hours for those norevivified. Adapted to increasing concentrations, allows the bacteria to degrade a substrate concentration of about 400mg/l in less than 350 hours.A second part was consisted in the determination of a substrate degradation model using the factorial experiment design,as a function of temperature (30-40°C and of the size of the inoculums (260.88 - 521.76mg/ l. The results were analyzedstatistically using the Student’s t-test, analysis of variance, and F-test. The value of R2 (0.99872 and adjusted R2 (0.9962close to 1.0, verifies the good correlation between the observed and the predicted values, and provides the excellent relationshipbetween the independent variables (factors and the response (the time of the phenol degradation. F-value found above200, indicates that the considered model is statistically significant.

  8. High intensity neutrino source superconducting solenoid cyrostat design

    Energy Technology Data Exchange (ETDEWEB)

    Page, T.M.; Nicol, T.H.; Feher, S.; Terechkine, I.; Tompkins, J.; /Fermilab

    2006-06-01

    Fermi National Accelerator Laboratory (FNAL) is involved in the development of a 100 MeV superconducting linac. This linac is part of the High Intensity Neutrino Source (HINS) R&D Program. The initial beam acceleration in the front end section of the linac is achieved using room temperature spoke cavities, each of which is combined with a superconducting focusing solenoid. These solenoid magnets are cooled with liquid helium at 4.5K, operate at 250 A and have a maximum magnetic field strength of 7.5 T. The solenoid cryostat will house the helium vessel, suspension system, thermal shield, multilayer insulation, power leads, instrumentation, a vacuum vessel and cryogenic distribution lines. This paper discusses the requirements and detailed design of these superconducting solenoid cryostats.

  9. Industry 4.0 learning factory didactic design parameters for industrial engineering education in South Africa

    Directory of Open Access Journals (Sweden)

    Sackey, S. M.

    2017-05-01

    Full Text Available To manage the impact of Industry 4.0 on industrial engineering (IE education curriculum requirements, realistic teaching and learning infrastructure such as a learning factory are required. This paper scans the literature to determine Industry 4.0’s principles and interactions with IE and a learning factory, surveys relevant universities by questionnaire to determine its current status and practices, and formulates didactic design parameters for an Industry 4.0 learning factory to support IE education in South Africa, making use of existing models of cyber-physical systems and learning factory morphology. In other results, the technical universities are discovered to be more positively disposed, in general terms, to developing an Industry 4.0 learning factory than are the traditional programmes which, with one exception, prefer computational facilities. Of ten universities that offer IE, only one — a traditional programme — has made significant progress towards creating an Industry 4.0 learning factory.

  10. Research and design progress of the Jinping Neutrino Experiment

    Science.gov (United States)

    Wang, Zhe

    2018-01-01

    Thanks to the 2400 m overburden and the long distance to commercial reactors, the China Jinping Underground Laboratory (CJPL) is an ideal site for low background neutrino experiments. The Jinping Neutrino Experiment will perform an in-depth research on solar neutrinos, geo-neutrinos and supernova relic neutrinos. Many efforts were devoted to the R&D of the experimental proposal. A new type of liquid scintillator, with high light-yield and Cherenkov and scintillation separation capability, is being developed. The assay and selection of low radioactive stainless-steel (SST) was carried out. A wide field-of-view of 90 degree and high-geometry-efficiency of 98% light concentrator is developed. At the same time, a 1-ton prototype is constructed and placed underground at Jinping laboratory. The simulation and analysis software, electromagnetic calorimeter function, rock damage zone simulation will also be introduced briefly.

  11. Experimental neutrino physics

    CERN Document Server

    Link, Jonathan M

    2018-01-01

    Neutrinos have a smaller mass than any other known particle and are the subject of intense recent studies, as well as this book. The author provides a coherent introduction to the necessary theoretical background and experimental methods used by modern neutrino physicists. It’s designed as a one-stop reference addressing what is currently known about the neutrino hypothesis, discovery of the neutrino, theory of weak interactions, solar neutrino puzzle, and neutrino oscillation. It then gives a detailed account of practical approaches for study of precision oscillations, neutrino mass and other neutrino properties, sterile neutrinos, and neutrino messengers from space and Earth’s interior.

  12. THE POTENTIAL FOR NEUTRINO PHYSICS AT MUON COLLIDERS AND DEDICATED HIGH CURRENT MUON STORAGE RINGS

    International Nuclear Information System (INIS)

    BIGI, I.; BOLTON, T.; FORMAGGIO, J.; HARRIS, D.; MORFIN, J.; SPENTZOURIS, P.; YU, J.; KAYSER, B.; KING, B.J.; MCFARLAND, K.; PETROV, A.; SCHELLMAN, H.; VELASCO, M.; SHROCK, R.

    2000-01-01

    Conceptual design studies are underway for both muon colliders and high-current non-colliding muon storage rings that have the potential to become the first true neutrino factories. Muon decays in long straight sections of the storage rings would produce uniquely intense and precisely characterized two-component neutrino beams--muon neutrinos plus electron antineutrinos from negative muon decays and electron neutrinos plus muon antineutrinos from positive muons. This article presents a long-term overview of the prospects for these facilities to greatly extend the capabilities for accelerator-based neutrino physics studies for both high rate and long baseline neutrino experiments. As the first major physics topic, recent experimental results involving neutrino oscillations have motivated a vigorous design effort towards dedicated neutrino factories that would store muon beams of energies 50 GeV or below. These facilities hold the promise of neutrino oscillation experiments with baselines up to intercontinental distances and utilizing well understood beams that contain, for the first time, a substantial component of multi-GeV electron-flavored neutrinos. In deference to the active and fast-moving nature of neutrino oscillation studies, the discussion of long baseline physics at neutrino factories has been limited to a concise general overview of the relevant theory, detector technologies, beam properties, experimental goals and potential physics capabilities. The remainder of the article is devoted to the complementary high rate neutrino experiments that would study neutrino-nucleon and neutrino-electron scattering and would be performed at high performance detectors placed as close as is practical to the neutrino production straight section of muon storage rings in order to exploit beams with transverse dimensions as small as a few tens of centimeters

  13. THE POTENTIAL FOR NEUTRINO PHYSICS AT MUON COLLIDERS AND DEDICATED HIGH CURRENT MUON STORAGE RINGS

    Energy Technology Data Exchange (ETDEWEB)

    BIGI,I.; BOLTON,T.; FORMAGGIO,J.; HARRIS,D.; MORFIN,J.; SPENTZOURIS,P.; YU,J.; KAYSER,B.; KING,B.J.; MCFARLAND,K.; PETROV,A.; SCHELLMAN,H.; VELASCO,M.; SHROCK,R.

    2000-05-11

    Conceptual design studies are underway for both muon colliders and high-current non-colliding muon storage rings that have the potential to become the first true neutrino factories. Muon decays in long straight sections of the storage rings would produce uniquely intense and precisely characterized two-component neutrino beams--muon neutrinos plus electron antineutrinos from negative muon decays and electron neutrinos plus muon antineutrinos from positive muons. This article presents a long-term overview of the prospects for these facilities to greatly extend the capabilities for accelerator-based neutrino physics studies for both high rate and long baseline neutrino experiments. As the first major physics topic, recent experimental results involving neutrino oscillations have motivated a vigorous design effort towards dedicated neutrino factories that would store muon beams of energies 50 GeV or below. These facilities hold the promise of neutrino oscillation experiments with baselines up to intercontinental distances and utilizing well understood beams that contain, for the first time, a substantial component of multi-GeV electron-flavored neutrinos. In deference to the active and fast-moving nature of neutrino oscillation studies, the discussion of long baseline physics at neutrino factories has been limited to a concise general overview of the relevant theory, detector technologies, beam properties, experimental goals and potential physics capabilities. The remainder of the article is devoted to the complementary high rate neutrino experiments that would study neutrino-nucleon and neutrino-electron scattering and would be performed at high performance detectors placed as close as is practical to the neutrino production straight section of muon storage rings in order to exploit beams with transverse dimensions as small as a few tens of centimeters.

  14. KAON factories

    International Nuclear Information System (INIS)

    Craddock, M.K.

    1989-09-01

    Proposals for high intensity proton synchrotrons (typically providing 100 μA (6 x 10 14 p/s)) at 30 GeV have been made in Canada, Europe, Japan, the USA and the USSR. These beams would be roughly 100 times more intense than those available now and would yield equivalent increases in the fluxes of secondary particles (kaons, pions, muons, antiprotons, hyperons and neutrinos) - or cleaner beams for a smaller increase in flux. The ability to investigate rare processes on the precision frontier opens new avenues to fundamental questions in both particle and nuclear physics, complementary to traditional approaches via the energy frontier. The demand for higher currents has led to novel features in many of the accelerator designs: asymmetric magnet cycles, avoidance of transition crossing, separate collector and stretcher rings, three-dimensional beam painting at injection, bucket-to-bucket beam transfer, perpendicular biassing of microwave ferrite in the rf tuners, the use of Siberian Snakes to preserve polarization, and the addition of a pre-septum to make slow extraction >99.8% efficient. Other characteristic features include rapid cycling rates, booster stages, H - injection, low impedance enclosures, powerful feedback systems for control of beam instabilities and beam loading, and local collimation systems for handling beam loss. This paper reviews the general features of kaon factory accelerator design and the status of the various proposals

  15. Long baseline neutrino oscillation experiment at the AGS. Physics design report

    International Nuclear Information System (INIS)

    Beavis, D.; Carroll, A.; Chiang, I.

    1995-04-01

    The authors present a design for a multi-detector long baseline neutrino oscillation experiment at the BNL AGS. It has been approved by the BNL-HENP-PAC as AGS Experiment 889. The experiment will search for oscillations in the ν μ , disappearance channel and the ν μ ↔ ν e appearance channel by means of four identical neutrino detectors located 1, 3, 24, and 68km from the AGS neutrino source. Observed depletion of the ν μ flux (via quasi-elastic muon neutrino events, ν μ n → μ - p) in the far detectors not attended by an observed proportional increase of the ν e flux (via quasi-elastic electron neutrino events, ν e n → e - p) in those detectors will be prima facie evidence for the oscillation channel ν μ ↔ ν τ . The experiment is directed toward exploration of the region of the neutrino oscillation parameters Δm 2 and sin 2 2θ, suggested by the Kamiokande and IMB deep underground detectors but it will also explore a region more than two orders of magnitude larger than that of previous accelerator experiments. The experiment will run in a mode new to BNL. It will receive the fast extracted proton beam on the neutrino target approximately 20 hours per day when the AGS is not filling RHIC. A key aspect of the experimental design involves placing the detectors 1.5 degrees off the center line of the neutrino beam, which has the important advantage that the central value of the neutrino energy (∼ 1 GeV) and the beam spectral shape are, to a good approximation, the same in all four detectors. The proposed detectors are massive, imaging, water Cherenkov detectors similar in large part to the Kamiokande and IMB detectors. The design has profited from their decade-long experience, and from the detector designs of the forthcoming SNO and SuperKamiokande detectors

  16. Accelerated and Rational Design of Improved CHO Cell Factories

    DEFF Research Database (Denmark)

    Grav, Lise Marie

    Recombinant production of therapeutic proteins provides huge benefits to human health and promises solutions to some of the most devastating and currently untreatable diseases in healthcare. Key to the development of new therapeutic proteins is to optimize and engineer living cells, namely cell...... of a number of novel tools is reported that aim to accelerate the construction of production cell lines for therapeutic proteins with optimal phenotypic attributes for industrial processes. Chinese hamster ovary (CHO) cells are the predominant production host for therapeutic proteins, and are the cell factory...... of interest in this thesis. The core of the thesis is revolved around the development and application of genome editing techniques that enable us to precisely engineer the genome of CHO cells by either rendering specific-targeted genes unfunctional or inserting new genes in precise genomic locations...

  17. Gaming in the Classroom: An Innovative Way to Teach Factorial Designs

    Science.gov (United States)

    Stansbury, Jessica A.; Munro, Geoffrey D.

    2013-01-01

    This study tested the effectiveness of video game use for instruction of factorial designs in a research methods course. Students designed and conducted a mini study, playing "Dance, Dance, Revolution", using video game scores as the dependent variable. A mixed-design analysis of variance revealed a significantly greater increase from pretest to…

  18. Algorithm for designing smart factory Industry 4.0

    Science.gov (United States)

    Gurjanov, A. V.; Zakoldaev, D. A.; Shukalov, A. V.; Zharinov, I. O.

    2018-03-01

    The designing task of production division of the Industry 4.0 item designing company is being studied. The authors proposed an algorithm, which is based on the modified V L Volkovich method. This algorithm allows generating options how to arrange the production with robotized technological equipment functioning in the automatic mode. The optimization solution of the multi-criteria task for some additive criteria is the base of the algorithm.

  19. Long baseline neutrino oscillation experiment at the AGS. Physics design report

    Energy Technology Data Exchange (ETDEWEB)

    Beavis, D.; Carroll, A.; Chiang, I. [Brookhaven National Lab., Long Island, NY (United States); E889 Collaboration

    1995-04-01

    The authors present a design for a multi-detector long baseline neutrino oscillation experiment at the BNL AGS. It has been approved by the BNL-HENP-PAC as AGS Experiment 889. The experiment will search for oscillations in the {nu}{sub {mu}}, disappearance channel and the {nu}{sub {mu}} {leftrightarrow} {nu}{sub e} appearance channel by means of four identical neutrino detectors located 1, 3, 24, and 68km from the AGS neutrino source. Observed depletion of the {nu}{sub {mu}} flux (via quasi-elastic muon neutrino events, {nu}{sub {mu}}n {yields} {mu}{sup {minus}}p) in the far detectors not attended by an observed proportional increase of the {nu}{sub e} flux (via quasi-elastic electron neutrino events, {nu}{sub e}n {yields} e{sup {minus}}p) in those detectors will be prima facie evidence for the oscillation channel {nu}{sub {mu}} {leftrightarrow} {nu}{sub {tau}}. The experiment is directed toward exploration of the region of the neutrino oscillation parameters {Delta}m{sup 2} and sin{sup 2}2{theta}, suggested by the Kamiokande and IMB deep underground detectors but it will also explore a region more than two orders of magnitude larger than that of previous accelerator experiments. The experiment will run in a mode new to BNL. It will receive the fast extracted proton beam on the neutrino target approximately 20 hours per day when the AGS is not filling RHIC. A key aspect of the experimental design involves placing the detectors 1.5 degrees off the center line of the neutrino beam, which has the important advantage that the central value of the neutrino energy ({approx} 1 GeV) and the beam spectral shape are, to a good approximation, the same in all four detectors. The proposed detectors are massive, imaging, water Cherenkov detectors similar in large part to the Kamiokande and IMB detectors. The design has profited from their decade-long experience, and from the detector designs of the forthcoming SNO and SuperKamiokande detectors.

  20. Clustering Words to Match Conditions: An Algorithm for Stimuli Selection in Factorial Designs

    Science.gov (United States)

    Guasch, Marc; Haro, Juan; Boada, Roger

    2017-01-01

    With the increasing refinement of language processing models and the new discoveries about which variables can modulate these processes, stimuli selection for experiments with a factorial design is becoming a tough task. Selecting sets of words that differ in one variable, while matching these same words into dozens of other confounding variables…

  1. Status of the Super-B factory Design

    CERN Document Server

    Wittmer, W; Chao, A; Novokhatski, A; Nosochkov, Y; Seeman, J; Sullivan, M K; Wienands, U; Weathersby, S; Bogomyagkov, A V; Levichev, E; Nikitin, S; Piminov, P; Shatilov, D; Sinyatkin, S; Vobly, P; Okunev, I N; Bolzon, B; Brunetti, L; Jeremie, A; Biagini, M E; Boni, R; Boscolo, M; Demma, T; Drago, A; Esposito, M; Guiducci, S; Liuzzo, S; Preger, M; Raimondi, P; Tomassini, S; Zobov, M; Paoloni, E; Fabbricatore, P; Musenich, R; Farinon, S; Bettoni, S; Poirier, F; Rimbault, C; Variola, A; Baylac, M; Bourrion, O; Monseu, N; Vescovi, C; Chance, A

    2011-01-01

    The SuperB international team continues to optimize the design of an electron-positron collider, which will allow the enhanced study of the origins of flavor physics. The project combines the best features of a linear collider (high single-collision luminosity) and a storage-ring collider (high repetition rate), bringing together all accelerator physics aspects to make a very high luminosity of 10$^{36}$ cm$^{-2}$ sec$^{-1}$. This asymmetric-energy collider with a polarized electron beam will produce hundreds of millions of B-mesons at the $\\Upsilon$(4S) resonance. The present design is based on extremely low emittance beams colliding at a large Piwinski angle to allow very low $\\beta_y^\\star$ without the need for ultra short bunches. Use of crab-waist sextupoles will enhance the luminosity, suppressing dangerous resonances and allowing for a higher beam-beam parameter. The project has flexible beam parameters, improved dynamic aperture, and spin-rotators in the Low Energy Ring for longitudinal polarization o...

  2. Possible kaon and antiproton factory designs for TRIUMF

    Energy Technology Data Exchange (ETDEWEB)

    Craddock, M K [British Columbia Univ., Vancouver (Canada); Kost, C J; Richardson, J R [British Columbia Univ., Vancouver (Canada). TRIUMF Facility

    1979-12-01

    Two alternative designs based on proton synchrotrons and isochronous ring cyclotrons, respectively are considered for accelerating high currents (<30 ..mu..A) from TRIUMF (0.45 GeV) to energies high enough for the production of high fluxes of kaons (8-10 GeV) and antiprotons (25-30 GeV). The first synchrotron would be fast cycling at 20 Hz, with third harmonic flat-topping to aid in injection and extraction. The cw beam from TRIUMF would be extracted in 100-turn macropulses at 22 ..mu..sec intervals. With 400 ..mu..A in TRIUMF and injection over 8-20 % of the magnet cycle, 30-80 ..mu..A could be accelerated to 10 GeV. A second synchrotron would accelerate 30 ..mu..A to 30 GeV for production of antiprotons. The ring cyclotron option would also be built in two stages, 0.45 to 3 GeV (15 sectors, 10 m radius) and 3 to 8.5 GeV (30 sectors, 20 m radius). With superconducting magnets (5 T) the weight of steel could be kept below 2000 tons for each ring. Large field-free regions between the spiral ium ions, are obtained with an av the polarimetry installation is being carried out.

  3. Harmonic filter design consideration for a tire-rubber factory

    Energy Technology Data Exchange (ETDEWEB)

    Zebardast, A. [Azad Univ., Tehran (Iran, Islamic Republic of). Abhar Branch]|[Sharif Univ., Tehran (Iran, Islamic Republic of); Mokhtari, H. [Azad Univ., Tehran (Iran, Islamic Republic of)

    2005-07-01

    Nonlinear loads and arc furnace loads are the main sources of harmonic currents in power distribution systems. Harmonic currents can cause reductions in system efficiency, and shorten the lifespan of transformers and capacitor banks. This paper provided details of a filter designed to attenuate harmonic currents at a tire company in Iran. The tire company was supplied by 3 distribution transformers and an emergency transformer. Main supply was through a 132 kV/20 kV transformer, which was connected to 2 A and B stations. The AC/DC drivers generated harmonics. Harmonic measurements were performed to determine the type and size of the required filters. A summary of site harmonic measurements was provided. A passive filter was placed at a medium voltage location. A sensitivity analysis was then performed in order to assess loading effects on filter performance. The analysis was performed on all possible configurations in the plant, including load change, capacitor bank step change, and transformer energization. Resonance conditions were also examined. Results showed that attention must be paid to the filter component rating in addition to potential resonant conditions. It was concluded that resonant conditions alter when system operating conditions change. 5 refs., 7 figs.

  4. Possible kaon and antiproton factory designs for TRIUMF

    International Nuclear Information System (INIS)

    Craddock, M.K.; Kost, C.J.; Richardson, J.R.

    1979-01-01

    Two alternative designs based on proton synchrotrons and isochronous ring cyclotrons, respectively are considered for accelerating high currents (<30 μA) from TRIUMF (0.45 GeV) to energies high enough for the production of high fluxes of kaons (8-10 GeV) and antiprotons (25-30 GeV). The first synchrotron would be fast cycling at 20 Hz, with third harmonic flat-topping to aid in injection and extraction. The cw beam from TRIUMF would be extracted in 100-turn macropulses at 22 μsec intervals. With 400 μA in TRIUMF and injection over 8-20 % of the magnet cycle, 30-80 μA could be accelerated to 10 GeV. A second synchrotron would accelerate 30 μA to 30 GeV for production of antiprotons. The ring cyclotron option would also be built in two stages, 0.45 to 3 GeV (15 sectors, 10 m radius) and 3 to 8.5 GeV (30 sectors, 20 m radius). With superconducting magnets (5 T) the weight of steel could be kept below 2000 tons for each ring. Large field-free regions between the spiral sector magnets allow room for multiple SIN-style accelerating cavities, permitting energy gains of many MeV/turn. Second or third harmonic cavities and the phase compression effect help in achieving separated turn extraction. Up to 100 % of the beam in TRIUMF could be accelerated to 8.5 GeV. (auth)

  5. Possible kaon and antiproton factory designs for TRIUMF

    International Nuclear Information System (INIS)

    Craddock, M.K.; Kost, C.J.; Richardson, J.R.

    1979-11-01

    Two alternative designs based on proton synchrotrons and isochronous ring cyclotrons, respectively are considered for accelerating high currents (>=30 μA) from TRIUMF (0.45 GeV) to energies high enough for the production of high fluxes of kaons (8-10 GeV) and antiprotons (25-30 GeV). The first synchrotron would be fast cycling at 20 Hz, with third harmonic flat-topping to aid in injection and extraction. The cw beam from TRIUMF would be extracted in 100-turn macropulses at 22 μsec intervals. With 400 μA in TRIUMF and injection over 8-20% of the magnet cycle, 30-80 μA could be accelerated to 10 GeV. A second synchrotron would accelerate 30 μA to 30 GeV for production of antiprotons. The ring cyclotron option would also be built in two stages, 0.45 to 3 GeV (15 sectors, 10 m radius) and 3 to 8.5 GeV (30 sectors, 20 m radius). With superconducting magnets (5 T) the weight of steel could be kept below 2000 tons for each ring. Large field-free regions between the spiral sector magnets allow room for multiple SIN-style accelerating cavities, permitting energy gains of many MeV/turn. Second or third harmonic cavities and the phase compression effect help in achieving separated turn extraction. Up to 100% of the beam in TRIUMF could be accelerated to 8.5 GeV. (auth)

  6. Beta Beams: an accelerator based facility to explore Neutrino oscillation physics

    CERN Document Server

    Wildner, E; Hansen, C; De Melo Mendonca, T; Stora, T; Payet, J; Chance, A; Zorin, V; Izotov, I; Rasin, S; Sidorov, A; Skalyga, V; De Angelis, G; Prete, G; Cinausero, M; Kravchuk, VL; Gramegna, F; Marchi, T; Collazuol, G; De Rosa, G; Delbar, T; Loiselet, M; Keutgen, T; Mitrofanov, S; Lamy, T; Latrasse, L; Marie-Jeanne, M; Sortais, P; Thuillier, T; Debray, F; Trophime, C; Hass, M; Hirsh, T; Berkovits, D; Stahl, A

    2011-01-01

    The discovery that the neutrino changes flavor as it travels through space has implications for the Standard Model of particle physics (SM)[1]. To know the contribution of neutrinos to the SM, needs precise measurements of the parameters governing the neutrino oscillations. This will require a high intensity beam-based neutrino oscillation facility. The EURONu Design Study will review three currently accepted methods of realizing this facility (the so-called Super-Beams, Beta Beams and Neutrino Factories) and perform a cost assessment that, coupled with the physics performance, will give means to the European research authorities to make a decision on the layout and construction of the future European neutrino oscillation facility. ”Beta Beams” produce collimated pure electron neutrino and antineutrino beams by accelerating beta active ions to high energies and letting them decay in a race-track shaped storage ring. EURONu Beta Beams are based on CERNs infrastructure and the fact that some of the already ...

  7. A mechanical design for a detection unit for a deep-sea neutrino telescope

    NARCIS (Netherlands)

    Berbee, E.M.; Boer Rookhuizen, H.; Heine, E.; de Wolf, E.

    2013-01-01

    The future KM3NeT neutrino telescope will be built on the seabed of the Mediterranean Sea at a depth between three and five kilometers. The high ambient pressure, but also the fact that the detector is hardly accessible, put severe constraints on the mechanical design of the detection units of the

  8. SuperB A High-Luminosity Asymmetric $e^+ e^-$ Super Flavour Factory : Conceptual Design Report

    CERN Document Server

    Bona, M.; Grauges Pous, E.; Colangelo, P.; De Fazio, F.; Palano, A.; Manghisoni, M.; Re, V.; Traversi, G.; Eigen, G.; Venturini, M.; Soni, N.; Bruschi, M.; De Castro, S.; Faccioli, P.; Gabrieli, A.; Giacobbe, B.; Semprini Cesare, N.; Spighi, R.; Villa, M.; Zoccoli, A.; Hearty, C.; McKenna, J.; Soni, A.; Khan, A.; Barniakov, A.Y.; Barniakov, M.Y.; Blinov, V.E.; Druzhinin, V.P.; Golubev, V.B.; Kononov, S.A.; Koop, I.A.; Kravchenko, E.A.; Levichev, E.B.; Nikitin, S.A.; Onuchin, A.P.; Piminov, P.A.; Serednyakov, S.I.; Shatilov, D.N.; Skovpen, Y.I.; Solodov, E.A.; Cheng, C.H.; Echenard, B.; Fang, F.; Hitlin, D.J.; Porter, F.C.; Asner, D.M.; Pham, T.N.; Fleischer, R.; Giudice, G.F.; Hurth, T.; Mangano, M.; Mancinelli, G.; Meadows, B.T.; Schwartz, A.J.; Sokoloff, M.D.; Soffer, A.; Beard, C.D.; Haas, T.; Mankel, R.; Hiller, G.; Ball, P.; Pappagallo, M.; Pennington, M.R.; Gradl, W.; Playfer, S.; Abada, A.; Becirevic, D.; Descotes-Genon, S.; Pene, O.; Andreotti, D.; Andreotti, M.; Bettoni, D.; Bozzi, C.; Calabresi, R.; Cecchi, A.; Cibinetto, G.; Franchini, P.; Luppi, E.; Negrini, M.; Petrella, A.; Piemontese, L.; Prencipe, E.; Santoro, V.; Stancari, G.; Anulli, F.; Baldini-Ferroli, R.; Biagini, M.E.; Boscolo, M.; Calcaterra, A.; Drago, A.; Finocchiaro, G.; Guiducci, S.; Isidori, G.; Pacetti, S.; Patteri, P.; Peruzzi, I.M.; Piccolo, M.; Preger, M.A.; Raimondi, P.; Rama, M.; Vaccarezza, C.; Zallo, A.; Zobov, M.; De Sangro, R.; Buzzo, A.; Lo Vetere, M.; Macri, M.; Monge, M.R.; Passaggio, S.; Patrignani, C.; Robutti, E.; Tosi, S.; Matias, J.; Panduro Vazquez, W.; Borzumati, F.; Eyges, V.; Prell, S.A.; Pedlar, T.K.; Korpar, S.; Pestonik, R.; Staric, M.; Neubert, M.; Denig, A.G.; Nierste, U.; Agoh, T.; Ohmi, K.; Ohnishi, Y.; Fry, J.R.; Touramanis, C.; Wolski, A.; Golob, B.; Krizan, P.; Flaecher, H.; Bevan, A.J.; Di Lodovico, F.; George, K.A.; Barlow, R.; Lafferty, G.; Jawahery, A.; Roberts, D.A.; Simi, G.; Patel, P.M.; Robertson, S.H.; Lazzaro, A.; Palombo, F.; Kaidalov, A.; Buras, A.J.; Tarantino, C.; Buchalla, G.; Sanda, A.I.; D'Ambrosio, G.; Ricciardi, G.; Bigi, I.; Jessop, C.P.; Losecco, J.M.; Honscheid, K.; Arnaud, N.; Chehab, R.; Fedala, Y.; Polci, F.; Roudeau, P.; Sordini, V.; Soskov, V.; Stocchi, A.; Variola, A.; Vivoli, A.; Wormser, G.; Zomer, F.; Bertolin, A.; Brugnera, R.; Gagliardi, N.; Gaz, A.; Margoni, M.; Morandin, M.; Posocco, M.; Rotondo, M.; Simonetto, F.; Stroili, R.; Bonneaud, G.R.; Lombardo, V.; Calderini, G.; Ratti, L.; Speziali, V.; Biasini, M.; Covarelli, R.; Manoni, E.; Servoli, L.; Angelini, C.; Batignani, G.; Bettarini, S.; Bosi, F.; Carpinelli, M.; Cenci, R.; Cervelli, A.; Dell'Orso, M.; Forti, F.; Giannetti, P.; Giorgi, M.; Lusiani, A.; Marchiori, G.; Massa, M.; Mazur, M.A.; Morsani, F.; Neri, N.; Paoloni, E.; Raffaelli, F.; Rizzo, G.; Walsh, J.; Braun, V.; Lenz, A.; Adams, G.S.; Danko, I.Z.; Baracchini, E.; Bellini, F.; Cavoto, G.; D'Orazio, A.; Del Re, D.; Di Marco, E.; Faccini, R.; Ferrarotto, F.; Gaspero, Mario; Jackson, P.; Martinelli, G.; Mazzoni, M.A.; Morganti, Silvio; Piredda, G.; Renga, F.; Silvestrini, L.; Voena, C.; Catani, L.; Di Ciaccio, A.; Messi, R.; Santovetti, E.; Satta, A.; Ciuchini, M.; Lubicz, V.; Wilson, F.F.; Godang, R.; Chen, X.; Liu, H.; Park, W.; Purohit, M.; Trivedi, A.; White, R.M.; Wilson, J.R.; Allen, M.T.; Aston, D.; Bartoldus, R.; Brodsky, S.J.; Cai, Y.; Coleman, J.; Convery, M.R.; DeBarger, S.; Dingfelder, J.C.; Dubois-Felsmann, G.P.; Ecklund, S.; Fisher, A.S.; Haller, G.; Heifets, S.A.; Kaminski, J.; Kelsey, M.H.; Kocian, M.L.; Leith, D.W.G.S.; Li, N.; Luitz, S.; Luth, V.; MacFarlane, D.; Messner, R.; Muller, D.R.; Nosochkov, Y.; Novokhatski, A.; Pivi, M.; Ratcliff, B.N.; Roodman, A.; Schwiening, J.; Seeman, J.; Snyder, A.; Sullivan, M.; Va'Vra, J.; Wienands, U.; Wisniewski, W.; Stoeck, H.; Cheng, H.Y.; Li, H.N.; Keum, Y.Y.; Gronau, M.; Grossman, Y.; Bianchi, F.; Gamba, D.; Gambino, P.; Marchetto, F.; Menichetti, Ezio A.; Mussa, R.; Pelliccioni, M.; Dalla Betta, G.F.; Bomben, M.; Bosisio, L.; Cartaro, C.; Lanceri, L.; Vitale, L.; Azzolini, V.; Bernabeu, J.; Lopez-March, N.; Martinez-Vidal, F.; Milanes, D.A.; Oyanguren, A.; Paradisi, P.; Pich, A.; Sanchis-Lozano, M.A.; Kowalewski, Robert V.; Roney, J.M.; Back, J.J.; Gershon, T.J.; Harrison, P.F.; Latham, T.E.; Mohanty, G.B.; Petrov, A.A.; Pierini, M.; INFN

    2007-01-01

    The physics objectives of SuperB, an asymmetric electron-positron collider with a luminosity above 10^36/cm^2/s are described, together with the conceptual design of a novel low emittance design that achieves this performance with wallplug power comparable to that of the current B Factories, and an upgraded detector capable of doing the physics in the SuperB environment.

  9. MapFactory - Towards a mapping design pattern for big geospatial data

    Science.gov (United States)

    Rautenbach, Victoria; Coetzee, Serena

    2018-05-01

    With big geospatial data emerging, cartographers and geographic information scientists have to find new ways of dealing with the volume, variety, velocity, and veracity (4Vs) of the data. This requires the development of tools that allow processing, filtering, analysing, and visualising of big data through multidisciplinary collaboration. In this paper, we present the MapFactory design pattern that will be used for the creation of different maps according to the (input) design specification for big geospatial data. The design specification is based on elements from ISO19115-1:2014 Geographic information - Metadata - Part 1: Fundamentals that would guide the design and development of the map or set of maps to be produced. The results of the exploratory research suggest that the MapFactory design pattern will help with software reuse and communication. The MapFactory design pattern will aid software developers to build the tools that are required to automate map making with big geospatial data. The resulting maps would assist cartographers and others to make sense of big geospatial data.

  10. Dynamic Supply Chain Design and Operations Plan for Connected Smart Factories with Additive Manufacturing

    Directory of Open Access Journals (Sweden)

    Byung Do Chung

    2018-04-01

    Full Text Available Interest in smart factories and smart supply chains has been increasing, and researchers have emphasized the importance and the effects of advanced technologies such as 3D printers, the Internet of Things, and cloud services. This paper considers an innovation in dynamic supply-chain design and operations: connected smart factories that share interchangeable processes through a cloud-based system for personalized production. In the system, customers are able to upload a product design file, an optimal supply chain design and operations plan are then determined based on the available resources in the network of smart factories. The concept of smart supply chains is discussed and six types of flexibilities are identified, namely: design flexibility, product flexibility, process flexibility, supply chain flexibility, collaboration flexibility, and strategic flexibility. Focusing on supply chain flexibility, a general planning framework and various optimization models for dynamic supply chain design and operations plan are proposed. Further, numerical experiments are conducted to analyze fixed, production, and transportation costs for various scenarios. The results demonstrate the extent of the dynamic supply chain design and operations problem, and the large variation in transportation cost.

  11. Full factorial design analysis of carbon nanotube polymer-cement composites

    Directory of Open Access Journals (Sweden)

    Fábio de Paiva Cota

    2012-08-01

    Full Text Available The work described in this paper is related to the effect of adding carbon nanotubes (CNT on the mechanical properties of polymer-cement composites. A full factorial design has been performed on 160 samples to identify the contribution provided by the following factors: polymeric phase addition, CNT weight addition and water/cement ratio. The response parameters of the full factorial design were the bulk density, apparent porosity, compressive strength and elastic modulus of the polymer-cement-based nanocomposites. All the factors considered in this analysis affected significantly the bulk density and apparent porosity of the composites. The compressive strength and elastic modulus were affected primarily by the cross-interactions between polymeric phase and CNT additions, and the water/cement ratio with polymeric phase factors.

  12. Application of Factorial Design for Gas Parameter Optimization in CO2 Laser Welding

    DEFF Research Database (Denmark)

    Gong, Hui; Dragsted, Birgitte; Olsen, Flemming Ove

    1997-01-01

    The effect of different gas process parameters involved in CO2 laser welding has been studied by applying two-set of three-level complete factorial designs. In this work 5 gas parameters, gas type, gas flow rate, gas blowing angle, gas nozzle diameter, gas blowing point-offset, are optimized...... to be a very useful tool for parameter optimi-zation in laser welding process. Keywords: CO2 laser welding, gas parameters, factorial design, Analysis of Variance........ The bead-on-plate welding specimens are evaluated by a number of quality char-acteristics, such as the penetration depth and the seam width. The significance of the gas pa-rameters and their interactions are based on the data found by the Analysis of Variance-ANOVA. This statistic methodology is proven...

  13. Beta Beams for Precision Measurements of Neutrino Oscillation Parameters

    CERN Document Server

    Wildner, E; Hansen, C; De Melo Mendonca, T; Stora, T; Damjanovic, S; Payet, J; Chancé, A; Zorin, V; Izotov, I; Rasin, S; Sidorov, A; Skalyga, V; De Angelis, G; Prete, G; Cinausero, M; Kravchuk, V; Gramegna, F; Marchi, T; Collazuol, G; Mezzetto, M; Delbar, T; Loiselet, M; Keutgen, T; Mitrofanov, S; Burt, G; Dexter, A; Lamy, T; Latrasse, L; Marie-Jeanne, M; Sortais, P; Thuillier, T; Debray, F; Trophime, C; Hass, M; Hirsh, T; Berkovits, D; Stahl, A; Vardaci, E; Di Nitto, A; Brondi, A; La Rana, G; Moro, R; De Rosa, G; Palladino, V

    2012-01-01

    Neutrino oscillations have implications for the Standard Model of particle physics. The CERN Beta Beam has outstanding capabilities to contribute to precision measurements of the parameters governing neutrino oscillations. The FP7 collaboration EUROnu (2008-2012) is a design study that will review three facilities (Super-Beams, Beta Beams and Neutrino Factories) and perform a cost assessment that, coupled with the physics performance, will give means to the European research authorities to make decisions on future European neutrino oscillation facilities. ”Beta Beams” produce collimated pure electron (anti)neutrinos by accelerating beta active ions to high energies and having them decay in a storage ring. Using existing machines and infrastructure is an advantage for the cost evaluation; however, this choice is also constraining the Beta Beams. Recent work to make the Beta Beam facility a solid option will be described: production of Beta Beam isotopes, the 60 GHz pulsed ECR source development, integratio...

  14. Design of the magnetized muon shield for the prompt-neutrino facility

    International Nuclear Information System (INIS)

    Baltay, C.; Bosek, N.; Couch, J.

    1982-01-01

    The main technical challenge in the design of the prompt neutrino beam is the magnetized muon shield. Two satisfactory alternate designs have been developed for such a shield during this past year and the background muon fluxes have been calculated by three independent programs at Columbia, Fermilab, and MIT. The background muon fluxes have been calculated to be satisfactory in all of the detectors that might use the beam. In Section III of this report we describe in detail the three Monte Carlo programs used in these calculations. In Section IV we give the details of the flux calculations for the E-613 shield and the comparisons with the observed fluxes with various configurations of that shield. In Section V we describe the designs that have been developed for the neutrino area shield. In Section VI we discuss the problem of proton beam transport losses and the associated muon fluxes. Finally, in Section VII a comparison of the two solutions is made which covers cost, effectiveness, schedule and responsiveness to future unknowns. We conclude that there are not overwhelming reasons for the choice of one design over the other. However, for a variety of secondary reasons the superconducting design offers advantages. We therefore propose the construction of the prompt neutrino facility with the superconducting magnet design

  15. Vacuum system design for the PEP-II B Factory High-Energy Ring

    International Nuclear Information System (INIS)

    Perkins, C.; Bostic, D.; Daly, E.

    1994-06-01

    The design of the vacuum system for the PEP-II B Factory High-Energy Ring is reviewed. The thermal design and vacuum requirements are particularly challenging in PEP-II due to high stored beam currents up to 3.0 amps in 1658 bunches. The vacuum chambers for the HER arcs are fabricated by electron beam welding extruded copper sections up to 6 m long. Design of these chambers and the vacuum PumPing configuration is described with results from vacuum and thermal analyses

  16. A Preliminary Interaction Region Design for a Super B-Factory

    CERN Document Server

    Sullivan, Michael K; Donald, Martin; Ecklund, Stanley; Novokhatski, Alexander; Seeman, John; Wienands, Ulrich

    2005-01-01

    The success of the two B-Factories (PEP-II and KEKB) has encouraged us to look at design parameters for a B-Factory with a 30-50 times increase in the luminosity of the present machines (L~1e36). In order to achieve this high luminosity, the beta y* values are reduced to 3-2 mm, the bunch spacing is minimized (0.6-0.3 m) and the bunch currents are increased. Total beam currents range from 5-25 A. The interaction region (IR) of these "SuperB" designs presents special challenges. Synchrotron radiation fans from local bending in shared magnets and from upstream sources pose difficulties due to the high power levels in these fans. High-order-mode(HOM)heating, effects that have been seen in the present B-factories, will become much more pronounced with the very short bunches and high beam currents. Masking the detector beam pipe from synchrotron radiation must take into account effects of HOM power generation. Backgrounds that are a function of the luminosity will become very important. We presen...

  17. Fractional Factorial Design for Parameter Sweep Experiments Using Nimrod/E

    Directory of Open Access Journals (Sweden)

    T.C. Peachey

    2008-01-01

    Full Text Available The techniques of formal experimental design and analysis are powerful tools for scientists and engineers. However, these techniques are currently underused for experiments conducted with computer models. This has motivated the incorporation of experimental design functionality into the Nimrod tool chain. Nimrod has been extensively used for exploration of the response of models to their input parameters; the addition of experimental design tools will combine the efficiency of carefully designed experiments with the power of distributed execution. This paper describes the incorporation of one type of design, the fractional factorial design, and associated analysis tools, into the Nimrod framework. The result provides a convenient environment that automates the design of an experiment, the execution of the jobs on a computational grid and the return of results, and which assists in the interpretation of those results. Several case studies are included which demonstrate various aspects of this approach.

  18. Core-collapse supernovae as possible counterparts of IceCube neutrino multiplets

    Energy Technology Data Exchange (ETDEWEB)

    Strotjohann, Nora Linn; Kowalski, Marek; Franckowiak, Anna [DESY, Zeuthen (Germany); Voge, Markus [Bonn Univ. (Germany). Physikalisches Institut; Collaboration: IceCube-Collaboration

    2016-07-01

    While an astrophysical neutrino flux has been detected by the IceCube Neutrino Observatory its sources remain so far unidentified. IceCube's Optical Follow-up Program is designed to search for the counterparts of neutrino multiplets using the full energy range of the IceCube detector down to 100 GeV. Two or more muon neutrinos arriving from the same direction within few seconds can trigger follow-up observations with optical and X-ray telescopes. Since 2010 the Palomar Transient Factory has followed up about 40 such neutrino alerts and detected several supernovae. Many of the detections are however likely random coincidences. In this talk I describe our search for supernovae and the prospects of identifying a supernova as a source of high-energy neutrinos.

  19. High intensity neutrino oscillation facilities in Europe

    Directory of Open Access Journals (Sweden)

    T. R. Edgecock

    2013-02-01

    Full Text Available The EUROnu project has studied three possible options for future, high intensity neutrino oscillation facilities in Europe. The first is a Super Beam, in which the neutrinos come from the decay of pions created by bombarding targets with a 4 MW proton beam from the CERN High Power Superconducting Proton Linac. The far detector for this facility is the 500 kt MEMPHYS water Cherenkov, located in the Fréjus tunnel. The second facility is the Neutrino Factory, in which the neutrinos come from the decay of μ^{+} and μ^{-} beams in a storage ring. The far detector in this case is a 100 kt magnetized iron neutrino detector at a baseline of 2000 km. The third option is a Beta Beam, in which the neutrinos come from the decay of beta emitting isotopes, in particular ^{6}He and ^{18}Ne, also stored in a ring. The far detector is also the MEMPHYS detector in the Fréjus tunnel. EUROnu has undertaken conceptual designs of these facilities and studied the performance of the detectors. Based on this, it has determined the physics reach of each facility, in particular for the measurement of CP violation in the lepton sector, and estimated the cost of construction. These have demonstrated that the best facility to build is the Neutrino Factory. However, if a powerful proton driver is constructed for another purpose or if the MEMPHYS detector is built for astroparticle physics, the Super Beam also becomes very attractive.

  20. Factorial experimental design intended for the optimization of the alumina purification conditions

    Science.gov (United States)

    Brahmi, Mounaouer; Ba, Mohamedou; Hidri, Yassine; Hassen, Abdennaceur

    2018-04-01

    The objective of this study was to determine the optimal conditions by using the experimental design methodology for the removal of some impurities associated with the alumina. So, three alumina qualities of different origins were investigated under the same conditions. The application of full-factorial designs on the samples of different qualities of alumina has followed the removal rates of the sodium oxide. However, a factorial experimental design was developed to describe the elimination of sodium oxide associated with the alumina. The experimental results showed that chemical analyze followed by XRF prior treatment of the samples, provided a primary idea concerning these prevailing impurities. Therefore, it appeared that the sodium oxide constituted the largest amount among all impurities. After the application of experimental design, analysis of the effectors different factors and their interactions showed that to have a better result, we should reduce the alumina quantity investigated and by against increase the stirring time for the first two samples, whereas, it was necessary to increase the alumina quantity in the case of the third sample. To expand and improve this research, we should take into account all existing impurities, since we found during this investigation that the levels of partial impurities increased after the treatment.

  1. MINU Main Injector Neutrino Upgrade: Conceptual Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Bogert, Dixon [Fermilab; Alber, Russ [Fermilab

    2007-02-01

    This Conceptual Design Report (CDR) is intended to be a selfconsistent basis for a project baseline cost estimate. It is not a Title 1 report and has not answered every technical design question. The current level of contingency is believed to be consistent with the degree of technical confidence in the design at this stage. It is recognized that some basic construction concerns will be reviewed and optimized during the remaining stages of the project.

  2. Optimization of wood flour acetylation by factorial design and partial least squares regression

    Directory of Open Access Journals (Sweden)

    Lisandra M. K. Nadal

    2012-01-01

    Full Text Available Acetylation was performed to reduce the polarity of wood and increase its compatibility with polymer matrices for the production of composites. These reactions were performed first as a function of acetic acid and anhydride concentration in a mixture catalyzed by sulfuric acid. A concentration of 50%/50% (v/v of acetic acid and anhydride was found to produced the highest conversion rate between the functional groups. After these reactions, the kinetics were investigated by varying times and temperatures using a 3² factorial design, and showed time was the most relevant parameter in determining the conversion of hydroxyl into carbonyl groups.

  3. DESIGN AND LAYOUT CONCEPTS FOR COMPACT, FACTORY-PRODUCED, TRANSPORTABLE, GENERATION IV REACTOR SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    Mynatt Fred R.; Townsend, L.W.; Williamson, Martin; Williams, Wesley; Miller, Laurence W.; Khan, M. Khurram; McConn, Joe; Kadak, Andrew C.; Berte, Marc V.; Sawhney, Rapinder; Fife, Jacob; Sedler, Todd L.; Conway, Larry E.; Felde, Dave K.

    2003-11-12

    The purpose of this research project is to develop compact (100 to 400 MWe) Generation IV nuclear power plant design and layout concepts that maximize the benefits of factory-based fabrication and optimal packaging, transportation and siting. The reactor concepts selected were compact designs under development in the 2000 to 2001 period. This interdisciplinary project was comprised of three university-led nuclear engineering teams identified by reactor coolant type (water, gas, and liquid metal) and a fourth Industrial Engineering team. The reactors included a Modular Pebble Bed helium-cooled concept being developed at MIT, the IRIS water-cooled concept being developed by a team led by Westinghouse Electric Company, and a Lead-Bismuth-cooled concept developed by UT. In addition to the design and layout concepts this report includes a section on heat exchanger manufacturing simulations and a section on construction and cost impacts of proposed modular designs.

  4. DESIGN AND LAYOUT CONCEPTS FOR COMPACT, FACTORY-PRODUCED, TRANSPORTABLE, GENERATION IV REACTOR SYSTEMS

    International Nuclear Information System (INIS)

    Mynatt, Fred R.; Townsend, L.W.; Williamson, Martin; Williams, Wesley; Miller, Laurence W.; Khan, M. Khurram; McConn, Joe; Kadak, Andrew C.; Berte, Marc V.; Sawhney, Rapinder; Fife, Jacob; Sedler, Todd L.; Conway, Larry E.; Felde, Dave K.

    2003-01-01

    The purpose of this research project is to develop compact (100 to 400 MWe) Generation IV nuclear power plant design and layout concepts that maximize the benefits of factory-based fabrication and optimal packaging, transportation and siting. The reactor concepts selected were compact designs under development in the 2000 to 2001 period. This interdisciplinary project was comprised of three university-led nuclear engineering teams identified by reactor coolant type (water, gas, and liquid metal) and a fourth Industrial Engineering team. The reactors included a Modular Pebble Bed helium-cooled concept being developed at MIT, the IRIS water-cooled concept being developed by a team led by Westinghouse Electric Company, and a Lead-Bismuth-cooled concept developed by UT. In addition to the design and layout concepts this report includes a section on heat exchanger manufacturing simulations and a section on construction and cost impacts of proposed modular designs

  5. High intensity neutrino oscillation facilities in Europe

    CERN Document Server

    Edgecock, T.R.; Davenne, T.; Densham, C.; Fitton, M.; Kelliher, D.; Loveridge, P.; Machida, S.; Prior, C.; Rogers, C.; Rooney, M.; Thomason, J.; Wilcox, D.; Wildner, E.; Efthymiopoulos, I.; Garoby, R.; Gilardoni, S.; Hansen, C.; Benedetto, E.; Jensen, E.; Kosmicki, A.; Martini, M.; Osborne, J.; Prior, G.; Stora, T.; Melo-Mendonca, T.; Vlachoudis, V.; Waaijer, C.; Cupial, P.; Chancé, A.; Longhin, A.; Payet, J.; Zito, M.; Baussan, E.; Bobeth, C.; Bouquerel, E.; Dracos, M.; Gaudiot, G.; Lepers, B.; Osswald, F.; Poussot, P.; Vassilopoulos, N.; Wurtz, J.; Zeter, V.; Bielski, J.; Kozien, M.; Lacny, L.; Skoczen, B.; Szybinski, B.; Ustrzycka, A.; Wroblewski, A.; Marie-Jeanne, M.; Balint, P.; Fourel, C.; Giraud, J.; Jacob, J.; Lamy, T.; Latrasse, L.; Sortais, P.; Thuillier, T.; Mitrofanov, S.; Loiselet, M.; Keutgen, Th.; Delbar, Th.; Debray, F.; Trophine, C.; Veys, S.; Daversin, C.; Zorin, V.; Izotov, I.; Skalyga, V.; Burt, G.; Dexter, A.C.; Kravchuk, V.L.; Marchi, T.; Cinausero, M.; Gramegna, F.; De Angelis, G.; Prete, G.; Collazuol, G.; Laveder, M.; Mazzocco, M.; Mezzetto, M.; Signorini, C.; Vardaci, E.; Di Nitto, A.; Brondi, A.; La Rana, G.; Migliozzi, P.; Moro, R.; Palladino, V.; Gelli, N.; Berkovits, D.; Hass, M.; Hirsh, T.Y.; Schaumann, M.; Stahl, A.; Wehner, J.; Bross, A.; Kopp, J.; Neuffer, D.; Wands, R.; Bayes, R.; Laing, A.; Soler, P.; Agarwalla, S.K.; Cervera Villanueva, A.; Donini, A.; Ghosh, T.; Gómez Cadenas, J.J.; Hernández, P.; Martín-Albo, J.; Mena, O.; Burguet-Castell, J.; Agostino, L.; Buizza-Avanzini, M.; Marafini, M.; Patzak, T.; Tonazzo, A.; Duchesneau, D.; Mosca, L.; Bogomilov, M.; Karadzhov, Y.; Matev, R.; Tsenov, R.; Akhmedov, E.; Blennow, M.; Lindner, M.; Schwetz, T.; Fernández Martinez, E.; Maltoni, M.; Menéndez, J.; Giunti, C.; González García, M. C.; Salvado, J.; Coloma, P.; Huber, P.; Li, T.; López-Pavón, J.; Orme, C.; Pascoli, S.; Meloni, D.; Tang, J.; Winter, W.; Ohlsson, T.; Zhang, H.; Scotto-Lavina, L.; Terranova, F.; Bonesini, M.; Tortora, L.; Alekou, A.; Aslaninejad, M.; Bontoiu, C.; Kurup, A.; Jenner, L.J.; Long, K.; Pasternak, J.; Pozimski, J.; Back, J.J.; Harrison, P.; Beard, K.; Bogacz, A.; Berg, J.S.; Stratakis, D.; Witte, H.; Snopok, P.; Bliss, N.; Cordwell, M.; Moss, A.; Pattalwar, S.; Apollonio, M.

    2013-02-20

    The EUROnu project has studied three possible options for future, high intensity neutrino oscillation facilities in Europe. The first is a Super Beam, in which the neutrinos come from the decay of pions created by bombarding targets with a 4 MW proton beam from the CERN High Power Superconducting Proton Linac. The far detector for this facility is the 500 kt MEMPHYS water Cherenkov, located in the Fr\\'ejus tunnel. The second facility is the Neutrino Factory, in which the neutrinos come from the decay of {\\mu}+ and {\\mu}- beams in a storage ring. The far detector in this case is a 100 kt Magnetised Iron Neutrino Detector at a baseline of 2000 km. The third option is a Beta Beam, in which the neutrinos come from the decay of beta emitting isotopes, in particular 6He and 18Ne, also stored in a ring. The far detector is also the MEMPHYS detector in the Fr\\'ejus tunnel. EUROnu has undertaken conceptual designs of these facilities and studied the performance of the detectors. Based on this, it has determined the ph...

  6. Formulation of topical bioadhesive gel of aceclofenac using 3-level factorial design.

    Science.gov (United States)

    Singh, Sanjay; Parhi, Rabinarayan; Garg, Anuj

    2011-01-01

    The objective of this work was to develop bioadhesive topical gel of Aceclofenac with the help of response-surface approach. Experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of Poloxamer 407 (PL-407 = X1) and hydroxypropylmethyl cellulose K100 M (HPMC = X2)] on the bioadhesive character of gel, rheological property of gel (consistency index), and in-vitro drug release. The best model was selected to fit the data. Mathematical equation was generated by Design Expert® software for the model which assists in determining the effect of independent variables. Response surface plots were also generated by the software for analyzing effect of the independent variables on the response. Quadratic model was found to be the best for all the responses. Both independent variable (X1 and X2) were found to have synergistic effect on bioadhesion (Y1) but the effect of HPMC was more pronounced than PL-407. Consistency index was enhanced by increasing the level of both independent variables. An antagonistic effect of both independent variables was found on cumulative percentage release of drug in 2 (Y3) and 8 h (Y4). Both independent variables approximately equally contributed the antagonistic effect on Y3 whereas antagonistic effect of HPMC was more pronounced than PL-407. The effect of formulation variables on the product characteristics can be easily predicted and precisely interpreted by using a 3-level factorial experimental design and generated quadratic mathematical equations.

  7. Testing non-standard CP violation in neutrino propagation

    International Nuclear Information System (INIS)

    Winter, Walter

    2009-01-01

    Non-standard physics which can be described by effective four fermion interactions may be an additional source of CP violation in the neutrino propagation. We discuss the detectability of such a CP violation at a neutrino factory. We assume the current baseline setup of the international design study of a neutrino factory (IDS-NF) for the simulation. We find that the CP violation from certain non-standard interactions is, in principle, detectable significantly below their current bounds - even if there is no CP violation in the standard oscillation framework. Therefore, a new physics effect might be mis-interpreted as the canonical Dirac CP violation, and a possibly even more exciting effect might be missed

  8. Accelerator Challenges and Opportunities for Future Neutrino Experiments

    International Nuclear Information System (INIS)

    Zisman, Michael S.

    2010-01-01

    There are three types of future neutrino facilities currently under study, one based on decays of stored beta-unstable ion beams (Beta Beams), one based on decays of stored muon beams (Neutrino Factory), and one based on the decays of an intense pion beam (Superbeam). In this paper we discuss the challenges each design team must face and the R and D being carried out to turn those challenges into technical opportunities. A new program, the Muon Accelerator Program, has begun in the U.S. to carry out the R D for muon-based facilities, including both the Neutrino Factory and, as its ultimate goal, a Muon Collider. The goals of this program will be briefly described.

  9. Design Study for a Future Laguna-LBNO Long-Baseline Neutrino Facility at CERN

    CERN Document Server

    Alabau-Gonzalvo, J; Antoniou, F; Benedikt, M; Calviani, M; Efthymiopoulos, I; Ferrari, A; Garoby, R; Gerigk, F; Gilardoni, S; Goddard, B; Kosmicki, A; Lazaridis, C; Osborne, J; Papaphillippou, Y; Parfenova, A; Shaposhnikova, E; Steerenberg, R; Velten, P; Vincke, H

    2013-01-01

    The Large Apparatus studying Grand Unification and Neutrino Astrophysics (LAGUNA) study [1] investigated seven pre-selected underground sites in Europe (Finland, France, Italy, Poland, Romania, Spain and UK), capable of housing large volume detectors for terrestrial, accelerator generated and astrophysical neutrino research. The study was focused on geo-technical assessment of the sites, concluding that no show-stoppers exist for the construction of the required large underground caverns in the chosen sites. The LAGUNA-LBNO FP7/EC-funded design study extends the LAGUNA study in two key aspects: the detailed engineering of detector construction and operation, and the study of a long-baseline neutrino beam from CERN, and possibly other accelerator centres in Europe. Based on the findings of the LAGUNA study, the Pyh¨asalmi mine in Finland is chosen as prime site for the far detector location. The mine offers the deepest underground location in Europe (-1400 m) and a baseline of 2’300 km from CERN (Fig. 1). ...

  10. Detector design studies for a cubic kilometre Deep Sea neutrino telescope - KM3NeT

    International Nuclear Information System (INIS)

    Carr, J; Dornic, D; Cohen, F; Jouvenot, F; Maurin, G; Naumann, C

    2008-01-01

    The KM3NeT consortium is currently preparing the construction of a cubic-kilometre sized neutrino telescope in the Mediterranean Sea as a continuation of the previous efforts by the three Mediterranean projects ANTARES, NEMO and NESTOR and as a counterpart to the South-Pole based IceCube detector. The main physics goals of KM3NeT include the detection of neutrinos from astrophysical sources such as active galactic nuclei, supernova remnants and gamma-ray bursts as well as the search for new physics, such as neutrino signals from neutralino annihilation. A key point during the early phases of this experiment is the determination of the ideal detector layout as well as of important design criteria such as required spatial and temporal resolution of the sensor elements, to optimise the sensitivity in the energy range of interest. For this purpose, several independent Monte-Carlo studies using a range of possible detector configurations are being performed. In this presentation, one of these studies, using the fast and flexible Mathematica-based simulation and reconstruction package NESSY, is described in more detail together with expected results for some exemplary detector configurations.

  11. Development and application of computer-aided design methods for cell factory optimization

    DEFF Research Database (Denmark)

    Cardoso, Joao

    Genetically modified organisms (GMOs) can be used to produce chemicals for everyday applications. Engineering microorganisms is a multidisciplinary task comprising four steps: design, build, test and learn. The design and learn phases rely on computational, statistical models, data analysis...... and machine learning. The process of creating strains with commercially relevant titers is time consuming and expensive. Computer-aided design (CAD) software can help scientists build better strains by providing models and algorithms that can be used to generate and test hypotheses before implementing them...... microbial cell factories. In this PhD thesis we present cameo, a CAD software for metabolic engineering that uses GEMs. State-of-the-art and novel algorithms are implemented in cameo. These algorithms have been made accessible using a high-level API to enable any user to start running them without having...

  12. Factorial design of a solar photocatalytic process to treatment of wastewater effluent

    Energy Technology Data Exchange (ETDEWEB)

    Francisco, Adriana Ribeiro; Paterniani, Jose Euclides Stipp [Universidade Estadual de Campinas (FEAGRI/UNICAMP), SP (Brazil). Fac. de Engenharia Agricola], E-mail: adriana.francisco@agr.unicamp.br; Kuwakino, Adriana Yuri [Universidade Estadual de Campinas (CESET/UNICAMP), Limeira, SP (Brazil). Centro Superior de Educacao Tecnologica

    2008-07-01

    Advanced treatments are attributed to improving the quality of various types of waste such as the sanitary wastewater. The heterogeneous photocatalysis is an alternative that allows to improve the effluents conditions. This is possible because many chemical compounds of environmental concern can be degraded using UV radiation on a semiconductor. However, to enable the efficiency of the process photocatalytic is necessary to conduct a study of optimization to establish favorable conditions between selected variables. The aim of this work was a reactor solar photocatalytic optimization using factorial design 2{sup k}, depending on variables: mass (TiO{sub 2}), time (min) and flow of air (L min{sup -1}), using as analytical response the removal of color. The experiment was conducted at the Faculty of Agricultural Engineering (FEAGRI) and it was used the sanitary wastewater of there. The results indicated that there were significant efficiency using combinations mass = 1000 mg L{sup -1}, time = 360 min and flow of air = 5 L min{sup -1}. In the calculations of factorial design, the time showed a marked positive effect of 7.76, while the flow of air, when in excess, had an inhibitor behavior, even getting positive effect. (author)

  13. SCREENING OF MEDIUM COMPOUNDS USING A TWO-LEVEL FACTORIAL DESIGN FOR SACCHAROMYCES BOULARDII

    Directory of Open Access Journals (Sweden)

    GUOWEI SHU

    2016-04-01

    Full Text Available Even if the probiotic effect of Saccharomyces boulardii is has been reported, this yeast is rarely used in medium composition. Based on single factor experiment, two-level factorial design was employed to evaluate the effect of carbon sources (sucrose, glucose, nitrogen sources (soy peptone, beef extract, yeast extract, calf serum, malt extract and salts (K2HPO4, KH2PO4, MgSO4, Na2HPO4, NaH2PO4, CaCl2, sodium citrate, sodium glutamate on the growth of S. boulardii. At the same time, the optical density (OD in the medium was measured at 560 nm after 36 h of incubation. The result of two-level factorial design experiment showed that calf serum (p = 0.0214 and sodium citrate (p = 0.0045 are the significant growth factors of S. boulardii, sucrose (p = 0.0861 and malt extract (p = 0.0763 are important factors. In addition, sucrose and sodium citrate showed positive effect on the growth of S. boulardii. However, calf serum and malt extract showed negative effect on the growth. And we determined that the optimum medium composition for S. boulardii was as follow: 37.5 g·L-1 sucrose, 6 g·L-1 calf serum, 6 g·L-1 malt extract, 5 g·L-1 sodium citrate.

  14. Optimization of LDL targeted nanostructured lipid carriers of 5-FU by a full factorial design

    Directory of Open Access Journals (Sweden)

    Sare Andalib

    2012-01-01

    Full Text Available Background: Nanostructured lipid carriers (NLC are a mixture of solid and liquid lipids or oils as colloidal carrier systems that lead to an imperfect matrix structure with high ability for loading water soluble drugs. The aim of this study was to find the best proportion of liquid and solid lipids of different types for optimization of the production of LDL targeted NLCs used in carrying 5-Fu by the emulsification-solvent evaporation method. Materials and Methods: The influence of the lipid type, cholesterol or cholesteryl stearate for targeting LDL receptors, oil type (oleic acid or octanol, lipid and oil% on particle size, surface charge, drug loading efficiency, and drug released percent from the NLCs were studied by a full factorial design. Results: The NLCs prepared by 54.5% cholesterol and 25% of oleic acid, showed optimum results with particle size of 105.8 nm, relatively high zeta potential of −25 mV, drug loading efficiency of 38% and release efficiency of about 40%. Scanning electron microscopy of nanoparticles confirmed the results of dynamic light scattering method used in measuring the particle size of NLCs. Conclusions: The optimization method by a full factorial statistical design is a useful optimization method for production of nanostructured lipid carriers.

  15. Rank-based permutation approaches for non-parametric factorial designs.

    Science.gov (United States)

    Umlauft, Maria; Konietschke, Frank; Pauly, Markus

    2017-11-01

    Inference methods for null hypotheses formulated in terms of distribution functions in general non-parametric factorial designs are studied. The methods can be applied to continuous, ordinal or even ordered categorical data in a unified way, and are based only on ranks. In this set-up Wald-type statistics and ANOVA-type statistics are the current state of the art. The first method is asymptotically exact but a rather liberal statistical testing procedure for small to moderate sample size, while the latter is only an approximation which does not possess the correct asymptotic α level under the null. To bridge these gaps, a novel permutation approach is proposed which can be seen as a flexible generalization of the Kruskal-Wallis test to all kinds of factorial designs with independent observations. It is proven that the permutation principle is asymptotically correct while keeping its finite exactness property when data are exchangeable. The results of extensive simulation studies foster these theoretical findings. A real data set exemplifies its applicability. © 2017 The British Psychological Society.

  16. Optimization of LDL targeted nanostructured lipid carriers of 5-FU by a full factorial design.

    Science.gov (United States)

    Andalib, Sare; Varshosaz, Jaleh; Hassanzadeh, Farshid; Sadeghi, Hojjat

    2012-01-01

    Nanostructured lipid carriers (NLC) are a mixture of solid and liquid lipids or oils as colloidal carrier systems that lead to an imperfect matrix structure with high ability for loading water soluble drugs. The aim of this study was to find the best proportion of liquid and solid lipids of different types for optimization of the production of LDL targeted NLCs used in carrying 5-Fu by the emulsification-solvent evaporation method. The influence of the lipid type, cholesterol or cholesteryl stearate for targeting LDL receptors, oil type (oleic acid or octanol), lipid and oil% on particle size, surface charge, drug loading efficiency, and drug released percent from the NLCs were studied by a full factorial design. The NLCs prepared by 54.5% cholesterol and 25% of oleic acid, showed optimum results with particle size of 105.8 nm, relatively high zeta potential of -25 mV, drug loading efficiency of 38% and release efficiency of about 40%. Scanning electron microscopy of nanoparticles confirmed the results of dynamic light scattering method used in measuring the particle size of NLCs. The optimization method by a full factorial statistical design is a useful optimization method for production of nanostructured lipid carriers.

  17. Design and Factory Test of the E /E- Frascati Linear Accelerator for DAFNE

    Energy Technology Data Exchange (ETDEWEB)

    Anamkath, H.; Lyons, S.; Nett, D.; Treas, P.; Whitham, K.; Zante, T.; /Titan Beta, Dublin; Miller, R.; /Titan Beta, Dublin /SLAC; Boni, R.; Hsieh, H.; Sannibale, F.; Vescovi, M.; Vignola, G.; /Frascati

    2011-11-28

    The electron-positron accelerator for the DAFNE project has been built and is in test at Titan Beta in Dublin, CA. This S-Band RF linac system utilizes four 45 MW sledded klystrons and 16-3 m accelerating structures to achieve the required performance. It delivers a 4 ampere electron beam to the positron converter and accelerates the resulting positrons to 550 MeV. The converter design uses a 4.3T pulsed tapered flux compressor along with a pseudo-adiabatic tapered field to a 5 KG solenoid over the first two positron accelerating sections. Quadrupole focusing is used after 100 MeV. The system performance is given in Table 1. This paper briefly describes the design and development of the various subassemblies in this system and gives the initial factory test data.

  18. Effects of process parameters on ozone washing for denim using 3/sup 3/ factorial design

    International Nuclear Information System (INIS)

    Asim, F.; Mahmood, M.

    2017-01-01

    Denim garment is getting popular day by day. It is highly demandable because of its versatility, comfort and durability. Different techniques of denim washing increase this demand drastically. Denim washing is the process to enhance the appearance of a garment. This enhanced appearance may be the aged look, faded look, greyer cast, or any other shade setting or resin application. The two most advanced washing techniques are; ozone wash and laser wash. The effects of ozone on environment as well as on the garment are significant and cannot be neglected because number of benefits achieved such as time saving, less energy consumption, chemical, labour cost reduction, less discharge of water and chemicals. Therefore, effects of process parameters on ozone washing for denim fabric have been investigated in this research work using three level factorial design. 33 factorial design has been designed and conducted to investigate the effect of gas concentration, time and speed on the response variables namely; Shrinkage, Tensile and Tear strength of ozone washing. The influence of individual factors and their interactions has been critically examined using software Design Expert 8.0. Prior to the analysis of variance model accuracy has been examined through various residuals plots. The study of residuals plots shown that the residuals are normally distributed and significant evidence of possible outliers was not found. So the model can be used to predicted results with 95% confidence interval. The results from the experiment suggest that two out of three factors were significant, which are speed and time that influences mainly on the tear strength of the denim garment. (author)

  19. Computer modelling of bunch-by-bunch feedback for the SLAC B-factory design

    International Nuclear Information System (INIS)

    Briggs, D.; Fox, J.D.; Hosseini, W.; Klaisner, L.; Morton, P.; Pellegrin, J.L.; Thompson, K.A.; Lambertson, G.

    1991-05-01

    The SLAC B-factory design, with over 1600 high current bunches circulating in each ring, will require a feedback system to avoid coupled-bunch instabilities. A computer model of the storage ring, including the RF system, wave fields, synchrotron radiation loss, and the bunch-by-bunch feedback system is presented. The feedback system model represents the performance of a fast phase detector front end (including system noise and imperfections), a digital filter used to generate a correction voltage, and a power amplifier and beam kicker system. The combined ring-feedback system model is used to study the feedback system performance required to suppress instabilities and to quantify the dynamics of the system. Results are presented which show the time development of coupled bunch instabilities and the damping action of the feedback system. 3 refs., 5 figs., 2 tabs

  20. Optimization of Emulsifying Effectiveness of Phytosterol in Milk Using Two-Level Fractional Factorial Design

    Directory of Open Access Journals (Sweden)

    He Yunxia

    2017-12-01

    Full Text Available In this paper emulsifying effects of seven emulsifiers including Tween 80, Span 80, tripolyglycerol monostearate, sodium stearoyl lactylate, sucrose ester, soy lecithin and monoglyceride on phytosterol in milk were investigated using single factor test and fractional factorial design. The addition for seven emulsifiers were in the following concentrations: 0.1%, 0.2%, 0.3%, 0.4%, 0.5% and 0.6%. The results revealed that tripolyglycerol monostearate, sucrose ester and monoglyceride had a significant emulsifying effect on phytosterol in milk, Tripolyglycerol monostearate showed a positive emulsifying effect on phytosterol in milk, while sucrose ester and monoglyceride exhibited a negative emulsifying effect on phytosterol in milk.

  1. Application of a complete factorial design for the production of zeaxanthin by Flavobacterium sp.

    Science.gov (United States)

    Masetto, A; Flores-Cotera, L B; Díaz, C; Langley, E; Sanchez, S

    2001-01-01

    Utilizing a four-liter fermentor and applying a complete factorial design 2(3), the combined effects of agitation speed, aeration rate, and corn steep liquor concentration on zeaxanthin production by Flavobacterium sp. were studied. Maximum growth and production of total carotenoids and zeaxanthin were obtained at 600 rpm, 2 vvm and 4.6% corn steep liquor. Under these conditions, zeaxanthin represented 86% of the total carotenoids produced. Lower values of the variables studied resulted in lower growth, volumetric production of zeaxanthin and total carotenoids, and favored the formation of other carotenoids such as beta-carotene and canthaxanthin. The positive effects on growth and total carotenoids and zeaxanthin formation were in a large extent due to the interaction of agitation/corn steep liquor. However, aeration also had a positive effect on growth.

  2. Preparation of one-step NiO/Ni-CGO composites using factorial design

    International Nuclear Information System (INIS)

    Araujo, A.J.M. de; Sousa, A R.O. de; Camposa, L.F.A.; Macedo, D.A.; Loureiro, F. J.A.; Fagg, D.P.

    2016-01-01

    This work deals with the synthesis, processing and characterization of NiO/Ni- CGO composite materials as potential solid oxide fuel cell (SOFC) anodes. The particulate materials were obtained by a one-step synthesis method and characterized by thermal analysis (prior to calcination) and X-ray diffraction (calcined powder). The ceramic processing of samples containing from 30 to 70 wt.% NiO was carried out by factorial design. Besides the NiO content controlled during the chemical synthesis, the impacts of the pore-former content (citric acid, used in proportions of 0, 7.5 and 15 wt.%) and the sintering temperature (1300, 1350 and 1400 °C) were also investigated. The open porosity of NiO-CGO composites and reduced Ni-CGO cermets was modeled as a function of factors (NiO content, citric acid content and sintering temperature) and interaction of factors. (author)

  3. Process of chemical recycling of post-consumer PET using a factorial design

    International Nuclear Information System (INIS)

    Lacerda, Carlos Eduardo de O.; Almeida, Yeda Medeiros B. de; Vinhas, Gloria M.

    2015-01-01

    The present study investigated important variables in the depolymerization reaction of post-consumer poly (ethylene terephthalate) - PET via alkaline hydrolysis. Through this reaction is obtained terephthalic acid (PTA), a monomer, which when purified, is used for the production of PET resin. The study was based on a 2"2 factorial design in which the independent variables were the concentration of NaOH solution and the reaction time, and the dependent variable was the yield of PTA obtained. The experiments that generated the best results, 100 % of yield, were obtained with the higher values of the independent variables. Statistical analysis showed that the concentration of NaOH solution is the variable that most influences in the process. The PTA obtained was analyzed by NMR ¹H technique, confirming the strong resemblance to commercial PTA obtained by petrochemical way. (author)

  4. Model-based design of bistable cell factories for metabolic engineering.

    Science.gov (United States)

    Srinivasan, Shyam; Cluett, William R; Mahadevan, Radhakrishnan

    2018-04-15

    Metabolism can exhibit dynamic phenomena like bistability due to the presence of regulatory motifs like the positive feedback loop. As cell factories, microorganisms with bistable metabolism can have a high and a low product flux at the two stable steady states, respectively. The exclusion of metabolic regulation and network dynamics limits the ability of pseudo-steady state stoichiometric models to detect the presence of bistability, and reliably assess the outcomes of design perturbations to metabolic networks. Using kinetic models of metabolism, we assess the change in the bistable characteristics of the network, and suggest designs based on perturbations to the positive feedback loop to enable the network to produce at its theoretical maximum rate. We show that the most optimal production design in parameter space, for a small bistable metabolic network, may exist at the boundary of the bistable region separating it from the monostable region of low product fluxes. The results of our analysis can be broadly applied to other bistable metabolic networks with similar positive feedback network topologies. This can complement existing model-based design strategies by providing a smaller number of feasible designs that need to be tested in vivo. http://lmse.biozone.utoronto.ca/downloads/. krishna.mahadevan@utoronto.ca. Supplementary data are available at Bioinformatics online.

  5. Application of fractional factorial design to improve hot smoked Nile Perch (Lates niloticus quality

    Directory of Open Access Journals (Sweden)

    Sokamté, T.A.

    2017-06-01

    Full Text Available The aim of this research was to study the parameters influencing moisture, salt and total phenol content of hot smoked Nile Perch and to compare the influence of processing conditions on its proximate composition and sensory quality. The effect on moisture, salt and total phenol content was investigated using fractional factorial design with seven factors and two levels: X1 for brine concentration, X2 for brining time, X3 for preliminary smoking-drying time, X4 for smoking time, X5 for hot smoking time, X6 for smoking temperature and X7 for hot smoking temperature. A Multiple Linear Regression Analysis was performed to fit the mathematical model to the collected data and the model tested using analysis of variance (ANOVA. Results of ANOVA indicated the good accuracy and highest significance of the mathematical model. The range of total protein and lipid content was 17.96 to 34.34% and 0.87 to 4.43%, respectively. The range of general acceptability of smoked Nile Perch was 4.6 to 8.2 based on 9-point hedonic scale. Based on the results obtained, including the overall acceptability, proximate composition and smoking criteria of finished product, samples produced with the following conditions: brining at 4% for 270min, drying at 30°C for 30min and the smoked time/temperature cycles following: 30°C/120min; 50°C/240min and 80°C/240min was the best and most accepted. The results derived from this study indicate that the fractional factorial design is a useful screening tool for improving industrial smoking process of Nile Perch.

  6. Using factorial experimental design to evaluate the separation of plastics by froth flotation.

    Science.gov (United States)

    Salerno, Davide; Jordão, Helga; La Marca, Floriana; Carvalho, M Teresa

    2018-03-01

    This paper proposes the use of factorial experimental design as a standard experimental method in the application of froth flotation to plastic separation instead of the commonly used OVAT method (manipulation of one variable at a time). Furthermore, as is common practice in minerals flotation, the parameters of the kinetic model were used as process responses rather than the recovery of plastics in the separation products. To explain and illustrate the proposed methodology, a set of 32 experimental tests was performed using mixtures of two polymers with approximately the same density, PVC and PS (with mineral charges), with particle size ranging from 2 to 4 mm. The manipulated variables were frother concentration, air flow rate and pH. A three-level full factorial design was conducted. The models establishing the relationships between the manipulated variables and their interactions with the responses (first order kinetic model parameters) were built. The Corrected Akaike Information Criterion was used to select the best fit model and an analysis of variance (ANOVA) was conducted to identify the statistically significant terms of the model. It was shown that froth flotation can be used to efficiently separate PVC from PS with mineral charges by reducing the floatability of PVC, which largely depends on the action of pH. Within the tested interval, this is the factor that most affects the flotation rate constants. The results obtained show that the pure error may be of the same magnitude as the sum of squares of the errors, suggesting that there is significant variability within the same experimental conditions. Thus, special care is needed when evaluating and generalizing the process. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. New phenomena in neutrino physics

    Energy Technology Data Exchange (ETDEWEB)

    Kopp, Joachim

    2009-04-15

    In this thesis, we discuss two new concepts in neutrino physics: The neutrino Moessbauer effect and non-standard neutrino interactions. We show that neutrinos emitted and absorbed in recoil-free processes (Moessbauer neutrinos) can oscillate in spite of their near monochromaticity. We support this statement by quantum mechanical wave packet arguments and by a quantum field theoretical (QFT) calculation of the combined rate of Moessbauer neutrino emission, propagation and absorption. The QFT approach does not require any a priori assumptions on the neutrino wave function, and it allows us to include a realistic treatment of the different mechanisms leading to broadening of the emission and absorption lines. In the second part of this work, we study the phenomenology of non-standard neutrino interactions (NSI). We classifying the allowed NSI operators according to their impact on future oscillation experiments and present numerical results for the NSI sensitivities of reactor, superbeam and neutrino factory experiments. We point out that NSI could mimic standard oscillation effects, and might therefore lead to incorrect fit values for the oscillation parameters. For the case of the neutrino factory, we perform a detailed optimisation study to determine the optimum muon energy and detector configuration. (orig.)

  8. New phenomena in neutrino physics

    International Nuclear Information System (INIS)

    Kopp, Joachim

    2009-01-01

    In this thesis, we discuss two new concepts in neutrino physics: The neutrino Moessbauer effect and non-standard neutrino interactions. We show that neutrinos emitted and absorbed in recoil-free processes (Moessbauer neutrinos) can oscillate in spite of their near monochromaticity. We support this statement by quantum mechanical wave packet arguments and by a quantum field theoretical (QFT) calculation of the combined rate of Moessbauer neutrino emission, propagation and absorption. The QFT approach does not require any a priori assumptions on the neutrino wave function, and it allows us to include a realistic treatment of the different mechanisms leading to broadening of the emission and absorption lines. In the second part of this work, we study the phenomenology of non-standard neutrino interactions (NSI). We classifying the allowed NSI operators according to their impact on future oscillation experiments and present numerical results for the NSI sensitivities of reactor, superbeam and neutrino factory experiments. We point out that NSI could mimic standard oscillation effects, and might therefore lead to incorrect fit values for the oscillation parameters. For the case of the neutrino factory, we perform a detailed optimisation study to determine the optimum muon energy and detector configuration. (orig.)

  9. Advanced Envelope Research for Factory Built Housing, Phase 3 -- Design Development and Prototyping

    Energy Technology Data Exchange (ETDEWEB)

    Levy, E. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Kessler, B. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Mullens, M. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Rath, P. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2014-01-01

    The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective alternative envelope designs. In the near term, these technologies will play a central role in meeting stringent energy code requirements. For manufactured homes, the thermal requirements, last updated by statute in 1994, will move up to the more rigorous IECC 2012 levels in 2013, the requirements of which are consistent with site built and modular housing. This places added urgency on identifying envelope technologies that the industry can implement in the short timeframe. The primary goal of this research is to develop wall designs that meet the thermal requirements based on 2012 IECC standards. Given the affordable nature of manufactured homes, impact on first cost is a major consideration in developing the new envelope technologies. This work is part of a four-phase, multi-year effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three selected methods for building high performance wall systems. Phase 2 focused on the development of viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped critique and select the most viable solution to move further in the research -- stud walls with continuous exterior insulation. Phase 3, the subject of the current report, focused on the design development of the selected wall concept and explored variations on the use of exterior foam insulation. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing.

  10. Advanced Envelope Research for Factory Built Housing, Phase 3. Design Development and Prototyping

    Energy Technology Data Exchange (ETDEWEB)

    Levy, E. [ARIES Collaborative, New York, NY (United States); Kessler, B. [ARIES Collaborative, New York, NY (United States); Mullens, M. [ARIES Collaborative, New York, NY (United States); Rath, P. [ARIES Collaborative, New York, NY (United States)

    2014-01-01

    The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective alternative envelope designs. In the near term, these technologies will play a central role in meeting stringent energy code requirements. For manufactured homes, the thermal requirements, last updated by statute in 1994, will move up to the more rigorous IECC 2012 levels in 2013, the requirements of which are consistent with site built and modular housing. This places added urgency on identifying envelope technologies that the industry can implement in the short timeframe. The primary goal of this research is to develop wall designs that meet the thermal requirements based on 2012 IECC standards. Given the affordable nature of manufactured homes, impact on first cost is a major consideration in developing the new envelope technologies. This work is part of a four-phase, multi-year effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three selected methods for building high performance wall systems. Phase 2 focused on the development of viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped critique and select the most viable solution to move further in the research -- stud walls with continuous exterior insulation. Phase 3, the subject of the current report, focused on the design development of the selected wall concept and explored variations on the use of exterior foam insulation. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing.

  11. The LAGUNA design study-towards giant liquid based underground detectors for neutrino physics and astrophysics and proton decay searches

    CERN Document Server

    Angus, D; Autiero, D.; Apostu, A.; Badertscher, A.; Bennet, T.; Bertola, G.; Bertola, P.F.; Besida, O.; Bettini, A.; Booth, C.; Borne, J.L.; Brancus, I.; Bujakowsky, W.; Campagne, J.E.; Danil, G.Cata; Chipesiu, F.; Chorowski, M.; Cripps, J.; Curioni, A.; Davidson, S.; Declais, Y.; Drost, U.; Duliu, O.; Dumarchez, J.; Enqvist, T.; Ereditato, A.; von Feilitzsch, F.; Fynbo, H.; Gamble, T.; Galvanin, G.; Gendotti, A.; Gizicki, W.; Goger-Neff, M.; Grasslin, U.; Gurney, D.; Hakala, M.; Hannestad, S.; Haworth, M.; Horikawa, S.; Jipa, A.; Juget, F.; Kalliokoski, T.; Katsanevas, S.; Keen, M.; Kisiel, J.; Kreslo, I.; Kudryastev, V.; Kuusiniemi, P.; Labarga, L.; Lachenmaier, T.; Lanfranchi, J.C.; Lazanu, I.; Lewke, T.; Loo, K.; Lightfoot, P.; Lindner, M.; Longhin, A.; Maalampi, J.; Marafini, M.; Marchionni, A.; Margineanu, R.M.; Markiewicz, A.; Marrodan-Undagoita, T.; Marteau, J.E.; Matikainen, R.; Meindl, Q.; Messina, M.; Mietelski, J.W.; Mitrica, B.; Mordasini, A.; Mosca, L.; Moser, U.; Nuijten, G.; Oberauer, L.; Oprina, A.; Paling, S.; Pascoli, S.; Patzak, T.; Pectu, M.; Pilecki, Z.; Piquemal, F.; Potzel, W.; Pytel, W.; Raczynski, M.; Rafflet, G.; Ristaino, G.; Robinson, M.; Rogers, R.; Roinisto, J.; Romana, M.; Rondio, E.; Rossi, B.; Rubbia, A.; Sadecki, Z.; Saenz, C.; Saftoiu, A.; Salmelainen, J.; Sima, O.; Slizowski, J.; Slizowski, K.; Sobczyk, J.; Spooner, N.; Stoica, S.; Suhonen, J.; Sulej, R.; Szarska, M.; Szeglowski, T.; Temussi, M.; Thompson, J.; Thompson, L.; Trzaska, W.H.; Tippmann, M.; Tonazzo, A.; Urbanczyk, K.; Vasseur, G.; Williams, A.; Winter, J.; Wojutszewska, K.; Wurm, M.; Zalewska, A.; Zampaolo, M.; Zito, M.

    2010-01-01

    The feasibility of a next generation neutrino observatory in Europe is being considered within the LAGUNA design study. To accommodate giant neutrino detectors and shield them from cosmic rays, a new very large underground infrastructure is required. Seven potential candidate sites in different parts of Europe and at several distances from CERN are being studied: Boulby (UK), Canfranc (Spain), Fr\\'ejus (France/Italy), Pyh\\"asalmi (Finland), Polkowice-Sieroszowice (Poland), Slanic (Romania) and Umbria (Italy). The design study aims at the comprehensive and coordinated technical assessment of each site, at a coherent cost estimation, and at a prioritization of the sites within the summer 2010.

  12. Design of a nitrogen purification system with cryogenic method for neutrino detection.

    Science.gov (United States)

    Peng, Zhang; Zhongjun, Hu; Bingming, Wang; Qing, Li

    2018-04-04

    In order to detect the neutrino with liquid scintillation detector, high-purity nitrogen is essential for gas stripping in this detector. Therefore, it is necessary to design a purification system for the detector to purify nitrogen. Using the method of low temperature adsorption for the purification system, the key designs including the flow path, the adsorber and the selection of activated carbon, are introduced in this study. In these designs, the selection of activated carbon is the most important because the adsorption characteristic of the carbon is related to the performance of the purification system. The method of grand canonical ensemble Monte Carlo is adopted to simulate the adsorption of radon by the activated carbon with its slit pore model. Using this method, the working temperature and the key characteristic of the activated carbon are obtained. Copyright © 2018 Elsevier Ltd. All rights reserved.

  13. A mechanical design for a detection unit for a deep-sea neutrino telescope

    Energy Technology Data Exchange (ETDEWEB)

    Berbee, E.M.; Boer Rookhuizen, H.; Heine, E.; Mul, G. [Nikhef, Science Park 105, 1098 XG Amsterdam (Netherlands); Wolf, E. de, E-mail: e.dewolf@nikhef.nl [University of Amsterdam, Science Park 904, 1098 XH Amsterdam (Netherlands); Nikhef, Science Park 105, 1098 XG Amsterdam (Netherlands)

    2013-10-11

    The future KM3NeT neutrino telescope will be built on the seabed of the Mediterranean Sea at a depth between three and five kilometers. The high ambient pressure, but also the fact that the detector is hardly accessible, put severe constraints on the mechanical design of the detection units of the telescope. A detection unit is a vertical structure that supports the optical sensors of the telescope. It has a height of almost 900 m; two data cables run along the full length of the structure. The detection unit will be installed at the seabed as a compact package. Once acoustically released, it unfurls to its full length. The stability of the detection unit during unfurling and during operation is an important requirement for the mechanical design of the structure. We present the evolution of the design of the detection unit for the KM3NeT detector.

  14. A mechanical design for a detection unit for a deep-sea neutrino telescope

    International Nuclear Information System (INIS)

    Berbee, E.M.; Boer Rookhuizen, H.; Heine, E.; Mul, G.; Wolf, E. de

    2013-01-01

    The future KM3NeT neutrino telescope will be built on the seabed of the Mediterranean Sea at a depth between three and five kilometers. The high ambient pressure, but also the fact that the detector is hardly accessible, put severe constraints on the mechanical design of the detection units of the telescope. A detection unit is a vertical structure that supports the optical sensors of the telescope. It has a height of almost 900 m; two data cables run along the full length of the structure. The detection unit will be installed at the seabed as a compact package. Once acoustically released, it unfurls to its full length. The stability of the detection unit during unfurling and during operation is an important requirement for the mechanical design of the structure. We present the evolution of the design of the detection unit for the KM3NeT detector

  15. The TRIUMF KAON factory

    International Nuclear Information System (INIS)

    Craddock, M.K.

    1991-05-01

    The TRIUMF KAON Factory is designed to produce beams of kaons, antiprotons, other hadrons and neutrinos 100 times more intense, or cleaner, than are available now, for a broad range of particle and nuclear physics experiments. This will require a 100 μA beam of 30 GeV protons, to be produced by an interleaved sequence of two fast-cycling synchrotrons and three storage rings, with the existing TRIUMF H - cyclotron as injector. An $11-million preconstruction study has enabled the overall design to be reviewed and prototypes of various components to be built and evaluated -fast-cycling dipole and quadrupole magnets, a dual-frequency magnet power supply, ceramic beam pipes with internal RF shields, an RF cavity (using perpendicular bias), an extraction kicker, and RF beam chopper, and production targets. Environmental, industrial and economic impact studies have also been completed and the cost estimates and schedule updated. The total cost of $708 million (Canadian) will be shared equally between Canada, British Columbia (already approved) and international contributors. The federal decision is expected shortly. (Author) 29 refs., 5 figs

  16. The TRIUMF KAON Factory

    International Nuclear Information System (INIS)

    Craddock, M.K.

    1990-11-01

    The TRIUMF KAON Factory is designed to produce beams of kaons, antiprotons, other hadrons and neutrinos 100 times more intense, or cleaner, than are available now, for a broad range of experiments in particle and nuclear physics. This will require a 100 μA beam of 30 GeV protons, to be produced by an interleaved sequence of two fast-cycling synchrotrons and three storage rings, with the existing TRIUMF H - cyclotron as injector. An $11-million preconstruction study has enabled the overall design to be reviewed and prototypes of various accelerator components to be built and evaluated. Environmental, industrial and economic impact studies have also been completed. Payment of one-third of the total cost of $708 million (Canadian) has been approved by the government of British Columbia; a further third is expected from international sources, on the basis of inter-governmental consultations. A decision on the final third is expected from the government of Canada before the end of 1990. (Author) (15 refs., 7 figs.)

  17. Testing CPT invariance with neutrinos

    International Nuclear Information System (INIS)

    Ohlsson, Tommy

    2003-01-01

    We investigate possible tests of CPT invariance on the level of event rates at neutrino factories. We do not assume any specific model, but phenomenological differences in the neutrino-antineutrino masses and mixing angles in a Lorentz invariance preserving context, which could be induced by physics beyond the Standard Model. We especially focus on the muon neutrino and antineutrino disappearance channels in order to obtain constraints on the neutrino-antineutrino mass and mixing angle differences. In a typical neutrino factory setup simulation, we find, for example, that vertical bar m 3 - m-bar 3 vertical bar $1.9 · 10 -4 eV and vertical bar ≡ 23 - ≡-bar 23 vertical bar < or approx. 2 deg

  18. Design, engineering, and construction of photosynthetic microbial cell factories for renewable solar fuel production.

    Science.gov (United States)

    Lindblad, Peter; Lindberg, Pia; Oliveira, Paulo; Stensjö, Karin; Heidorn, Thorsten

    2012-01-01

    There is an urgent need to develop sustainable solutions to convert solar energy into energy carriers used in the society. In addition to solar cells generating electricity, there are several options to generate solar fuels. This paper outlines and discusses the design and engineering of photosynthetic microbial systems for the generation of renewable solar fuels, with a focus on cyanobacteria. Cyanobacteria are prokaryotic microorganisms with the same type of photosynthesis as higher plants. Native and engineered cyanobacteria have been used by us and others as model systems to examine, demonstrate, and develop photobiological H(2) production. More recently, the production of carbon-containing solar fuels like ethanol, butanol, and isoprene have been demonstrated. We are using a synthetic biology approach to develop efficient photosynthetic microbial cell factories for direct generation of biofuels from solar energy. Present progress and advances in the design, engineering, and construction of such cyanobacterial cells for the generation of a portfolio of solar fuels, e.g., hydrogen, alcohols, and isoprene, are presented and discussed. Possibilities and challenges when introducing and using synthetic biology are highlighted.

  19. Assessment of the recycling potential of fresh concrete waste using a factorial design of experiments.

    Science.gov (United States)

    Correia, S L; Souza, F L; Dienstmann, G; Segadães, A M

    2009-11-01

    Recycling of industrial wastes and by-products can help reduce the cost of waste treatment prior to disposal and eventually preserve natural resources and energy. To assess the recycling potential of a given waste, it is important to select a tool capable of giving clear indications either way, with the least time and work consumption, as is the case of modelling the system properties using the results obtained from statistical design of experiments. In this work, the aggregate reclaimed from the mud that results from washout and cleaning operations of fresh concrete mixer trucks (fresh concrete waste, FCW) was recycled into new concrete with various water/cement ratios, as replacement of natural fine aggregates. A 3(2) factorial design of experiments was used to model fresh concrete consistency index and hardened concrete water absorption and 7- and 28-day compressive strength, as functions of FCW content and water/cement ratio, and the resulting regression equations and contour plots were validated with confirmation experiments. The results showed that the fresh concrete workability worsened with the increase in FCW content but the water absorption (5-10 wt.%), 7-day compressive strength (26-36 MPa) and 28-day compressive strength (32-44 MPa) remained within the specified ranges, thus demonstrating that the aggregate reclaimed from FCW can be recycled into new concrete mixtures with lower natural aggregate content.

  20. HPLC/DAD determination of rosmarinic acid in Salvia officinalis: sample preparation optimization by factorial design

    International Nuclear Information System (INIS)

    Oliveira, Karina B. de; Oliveira, Bras H. de

    2013-01-01

    Sage (Salvia officinalis) contains high amounts of the biologically active rosmarinic acid (RA) and other polyphenolic compounds. RA is easily oxidized, and may undergo degradation during sample preparation for analysis. The objective of this work was to develop and validate an analytical procedure for determination of RA in sage, using factorial design of experiments for optimizing sample preparation. The statistically significant variables for improving RA extraction yield were determined initially and then used in the optimization step, using central composite design (CCD). The analytical method was then fully validated, and used for the analysis of commercial samples of sage. The optimized procedure involved extraction with aqueous methanol (40%) containing an antioxidant mixture (ascorbic acid and ethylenediaminetetraacetic acid (EDTA)), with sonication at 45 deg C for 20 min. The samples were then injected in a system containing a C 18 column, using methanol (A) and 0.1% phosphoric acid in water (B) in step gradient mode (45A:55B, 0-5 min; 80A:20B, 5-10 min) with flow rate of 1.0 mL min−1 and detection at 330 nm. Using this conditions, RA concentrations were 50% higher when compared to extractions without antioxidants (98.94 ± 1.07% recovery). Auto-oxidation of RA during sample extraction was prevented by the use of antioxidants resulting in more reliable analytical results. The method was then used for the analysis of commercial samples of sage. (author)

  1. Design and alaysis of the PEP-II B-Factory HER QF5 quadrupole magnet

    International Nuclear Information System (INIS)

    Kendall, C.M.; Harvey, A.; Swan, J.; Yamamoto, R.; Yokota, T.; Tanabe, J.; Sullivan, M.; Wienands, U.

    1997-01-01

    The High Energy Ring (HER) in Stanford Linear Accelerator Center's PEP-II B-Factory employs two high field quality quadrupole magnets, labeled QF5, located in the Interaction Region (IR) symmetrically about the Interaction Point (IP), for final horizontal beam focusing. An asymmetric, septum, Collins quadrupole design is required for QF5 as a result of space constraints within the IR. Water cooled square hollow copper conductor is used in a two coil per pole configuration to develop the 61.7 kG/m and 82.2 kG/m gradients required for the HER 9 GeV and 12 GeV energy levels respectively. A 1.45 m long laminated iron core constructed in two halves with a 160 mm diameter aperture and pole tip shims shape the quadruple field. The QF5 field quality requirements include a multipole content of b n /b 2 ≤1 x 10 -4 for n = 3-15 at a radius of 78.1 mm. The QF5 quadrupole mechanical and magnetic design and analysis are presented

  2. HPLC/DAD determination of rosmarinic acid in Salvia officinalis: sample preparation optimization by factorial design

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Karina B. de [Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil). Dept. de Farmacia; Oliveira, Bras H. de, E-mail: bho@ufpr.br [Universidade Federal do Parana (UFPR), Curitiba, PR (Brazil). Dept. de Quimica

    2013-01-15

    Sage (Salvia officinalis) contains high amounts of the biologically active rosmarinic acid (RA) and other polyphenolic compounds. RA is easily oxidized, and may undergo degradation during sample preparation for analysis. The objective of this work was to develop and validate an analytical procedure for determination of RA in sage, using factorial design of experiments for optimizing sample preparation. The statistically significant variables for improving RA extraction yield were determined initially and then used in the optimization step, using central composite design (CCD). The analytical method was then fully validated, and used for the analysis of commercial samples of sage. The optimized procedure involved extraction with aqueous methanol (40%) containing an antioxidant mixture (ascorbic acid and ethylenediaminetetraacetic acid (EDTA)), with sonication at 45 deg C for 20 min. The samples were then injected in a system containing a C{sub 18} column, using methanol (A) and 0.1% phosphoric acid in water (B) in step gradient mode (45A:55B, 0-5 min; 80A:20B, 5-10 min) with flow rate of 1.0 mL min-1 and detection at 330 nm. Using this conditions, RA concentrations were 50% higher when compared to extractions without antioxidants (98.94 {+-} 1.07% recovery). Auto-oxidation of RA during sample extraction was prevented by the use of antioxidants resulting in more reliable analytical results. The method was then used for the analysis of commercial samples of sage. (author)

  3. Design, Engineering, and Construction of Photosynthetic Microbial Cell Factories for Renewable Solar Fuel Production

    Energy Technology Data Exchange (ETDEWEB)

    Lindblad, Peter; Lindberg, Pia; Stensjoe, Karin (Photochemistry and Molecular Science, Dept. of Chemistry-Aangstroem Laboratory, Uppsala Univ., Uppsala (Sweden)), E-mail: Peter.Lindblad@kemi.uu.se; Oliveira, Paulo (Instituto de Biologia Molecular e Celular, Porto (Portugal)); Heidorn, Thorsten (Bioforsk-Norwegian Inst. for Agricultural and Environmental Research, Aas Oslo, (Norway))

    2012-03-15

    There is an urgent need to develop sustainable solutions to convert solar energy into energy carriers used in the society. In addition to solar cells generating electricity, there are several options to generate solar fuels. This paper outlines and discusses the design and engineering of photosynthetic microbial systems for the generation of renewable solar fuels, with a focus on cyanobacteria. Cyanobacteria are prokaryotic microorganisms with the same type of photosynthesis as higher plants. Native and engineered cyanobacteria have been used by us and others as model systems to examine, demonstrate, and develop photobiological H{sub 2} production. More recently, the production of carbon-containing solar fuels like ethanol, butanol, and isoprene have been demonstrated. We are using a synthetic biology approach to develop efficient photosynthetic microbial cell factories for direct generation of biofuels from solar energy. Present progress and advances in the design, engineering, and construction of such cyanobacterial cells for the generation of a portfolio of solar fuels, e.g., hydrogen, alcohols, and isoprene, are presented and discussed. Possibilities and challenges when introducing and using synthetic biology are highlighted

  4. Electrodialytic desalination of brackish water: determination of optimal experimental parameters using full factorial design

    Science.gov (United States)

    Gmar, Soumaya; Helali, Nawel; Boubakri, Ali; Sayadi, Ilhem Ben Salah; Tlili, Mohamed; Amor, Mohamed Ben

    2017-12-01

    The aim of this work is to study the desalination of brackish water by electrodialysis (ED). A two level-three factor (23) full factorial design methodology was used to investigate the influence of different physicochemical parameters on the demineralization rate (DR) and the specific power consumption (SPC). Statistical design determines factors which have the important effects on ED performance and studies all interactions between the considered parameters. Three significant factors were used including applied potential, salt concentration and flow rate. The experimental results and statistical analysis show that applied potential and salt concentration are the main effect for DR as well as for SPC. The effect of interaction between applied potential and salt concentration was observed for SPC. A maximum value of 82.24% was obtained for DR under optimum conditions and the best value of SPC obtained was 5.64 Wh L-1. Empirical regression models were also obtained and used to predict the DR and the SPC profiles with satisfactory results. The process was applied for the treatment of real brackish water using the optimal parameters.

  5. Fluoride removal from diluted solutions by Donnan dialysis using full factorial design

    Energy Technology Data Exchange (ETDEWEB)

    Boubakri, Ali; Helali, Nawel; Tlili, Mohamed; Amor, Mohamed Ben [Center of Researches and Water Technologies, Soliman (Turkey)

    2014-03-15

    Excessive fluoride concentration in potable water can lead to fluorosis of teeth and bones. In the present study, Donnan dialysis (DD) is applied for the removal of fluoride ions from diluted sodium fluoride solutions. A four factor two level (2{sup 4}) full factorial design was used to investigate the influence of different physico-chemical parameters on fluoride removal efficiency (Y{sub F}) and fluoride flux (J{sub F}) through anion exchange membrane. The statistical design determines factors which have the important effects on Donnan dialysis performance and studies all interactions among the considered parameters. The four significant factors were initial fluoride concentration, feed flow rate, temperature and agitation speed. The experimental results and statistical analysis show that the temperature and agitation speed have positive effects on fluoride removal efficiency and the initial fluoride concentration has a negative effect. In the case of fluoride flux, feed flow rate and initial concentration are the main effect and all factors have a positive effect. The interaction between studied parameters was not negligible on two responses. A maximum fluoride removal of 75.52% was obtained under optimum conditions and the highest value of fluoride flux obtained was 2.4 mg/cm{sup 2}·h. Empirical regression models were also obtained and used to predict the flux and the fluoride removal profiles with satisfactory results.

  6. Formulation optimization of gentamicin loaded Eudragit RS100 microspheres using factorial design study.

    Science.gov (United States)

    Singh, Deependra; Saraf, Swarnlata; Dixit, Vinod Kumar; Saraf, Shailendra

    2008-04-01

    Gentamicin-Eudragit RS100 microspheres were prepared by modified double emulsion method. A 3(2) full factorial experiment was designed to study the effects of the composition of outer aqueous phase in terms of amount of glycerol (viscosity effect) and sodium chloride (osmotic pressure gradient effect) on the entrapment efficiency and % yield and microsphere size. The results of analysis of variance test for responses measured indicated that the test is significant (p>0.05). The contribution of sodium chloride concentration was found to be higher on entrapment efficiency and % yield, whereas glycerol produced significant effect on the mean diameter of microspheres. Microspheres demonstrated spherical particles in the size range of 33.24-60.43 microm. In vitro release profile of optimized formulation demonstrated sustained release for 24 h following Higuchi kinetics. Finally, drug bioactivity was found to remain intact after microencapsulation. Response surface graphs are presented to examine the effects of independent variables on the responses studied. Thus, by formulation design important parameters affecting formulation characteristics of gentamicin loaded Eudragit RS100 microspheres can be identified for controlled delivery with desirable characters in terms of maximum entrapment and yield.

  7. Sudbury neutrino observatory proposal

    International Nuclear Information System (INIS)

    Ewan, G.T.; Evans, H.C.; Lee, H.W.

    1987-10-01

    This report is a proposal by the Sudbury Neutrino Observatory (SNO) collaboration to develop a world class laboratory for neutrino astrophysics. This observatory would contain a large volume heavy water detector which would have the potential to measure both the electron-neutrino flux from the sun and the total solar neutrino flux independent of neutrino type. It will therefore be possible to test models of solar energy generation and, independently, to search for neutrino oscillations with a sensitivity many orders of magnitude greater than that of terrestrial experiments. It will also be possible to search for spectral distortion produced by neutrino oscillations in the dense matter of the sun. Finally the proposed detector would be sensitive to neutrinos from a stellar collapse and would detect neutrinos of all types thus providing detailed information on the masses of muon- and tau-neutrinos. The neutrino detector would contain 1000 tons of D20 and would be located more than 2000 m below ground in the Creighton mine near Sudbury. The operation and performance of the proposed detector are described and the laboratory design is presented. Construction schedules and responsibilities and the planned program of technical studies by the SNO collaboration are outlined. Finally, the total capital cost is estimated to be $35M Canadian and the annual operating cost, after construction, would be $1.8 M Canadian, including the insurance costs of the heavy water

  8. Resolution V fractional factorial Design for Screening of factors affecting weakly basic drugs liposomal systems.

    Science.gov (United States)

    El-Helaly, Sara Nageeb; Habib, Basant A; Abd El-Rahman, Mohamed K

    2018-04-21

    This study aims to investigate factors affecting weakly basic drugs liposomal systems. Resolution V fractional factorial design (2 V 5-1 ) is used as an example of screening designs that would better be used as a wise step before proceeding with detailed factors effects or optimization studies. Five factors probable to affect liposomal systems of weakly basic drugs were investigated using Amisulpride as a model drug. Factors studied were; A: Preparation technique B: Phosphatidyl choline (PhC) amount (mg) C: Cholesterol: PhC molar ratio, D: Hydration volume (ml) and E: Sonication type. Levels investigated were; Ammonium sulphate-pH gradient technique or Transmembrane zinc chelation-pH gradient technique, 200 or 400 mg, 0 or 0.5, 10 or 20 ml and bath or probe sonication for A, B, C, D and E respectively. Responses measured were Particle size (PS) (nm), Zeta potential (ZP) (mV) and Entrapment efficiency percent (EE%). Ion selective electrode was used as a novel method for measuring unentrapped drug concentration and calculating entrapment efficiency without the need for liposomal separation. Factors mainly affecting the studied responses were Cholesterol: PhC ratio and hydration volume for PS, preparation technique for ZP and preparation technique and hydration volume for EE%. The applied 2 V 5-1 design enabled the use of only 16 trial combinations for screening the influence of five factors on weakly basic drugs liposomal systems. This clarifies the value of the use of screening experiments before extensive investigation of certain factors in detailed optimization studies. Copyright © 2017. Published by Elsevier B.V.

  9. Informing the Uninformed: Optimizing the Consent Message Using a Fractional Factorial Design

    Science.gov (United States)

    Tait, Alan R.; Voepel-Lewis, Terri; Nair, Vijayan N.; Narisetty, Naveen N.; Fagerlin, Angela

    2013-01-01

    Objective Research information should be presented in a manner that promotes understanding. However, many parents and research subjects have difficulty understanding and making informed decisions. This study was designed to examine the effect of different communication strategies on parental understanding of research information. Participants 640 parents of children scheduled for elective surgery Design Observational study using a fractional factorial design Setting Large tertiary care children's hospital Interventions Parents were randomized to receive information about a hypothetical pain trial presented in one of 16 consent documents containing different combinations of 5 selected communication strategies (i.e., length, readability, processability [formatting], graphical display, and supplemental verbal disclosure). Main outcome measures Parents were interviewed to determine their understanding of the study elements (e.g., protocol, alternatives etc.) and their gist (main point) and verbatim (actual) understanding of the risks and benefits. Results Main effects for understanding were found for processability, readability, message length, use of graphics, and verbal discussion. Consent documents with high processability, 8th grade reading level, and graphics resulted in significantly greater gist and verbatim understanding compared with forms without these attributes (mean difference, 95% CI = 0.57, 0.26–0.88, correct responses out of 7 and 0.54, 0.20–0.88 correct responses out of 4 for gist and verbatim, respectively). Conclusions Results identified several communication strategy combinations that improved parents' understanding of research information. Adoption of these active strategies by investigators, clinicians, IRBs, and study sponsors represents a simple, practical, and inexpensive means to optimize the consent message and enhance parental, participant, and patient understanding. PMID:23700028

  10. Optimization Of Freeze-Dried Starter For Yogurt By Full Factorial Experimental Design

    Directory of Open Access Journals (Sweden)

    Chen He

    2015-12-01

    Full Text Available With the rapidly development of fermented milk product, it is significant for enhancing the performance of starter culture. This paper not only investigated the influence of anti-freeze factors and freeze-drying protective agents on viable count, freeze-drying survival rate and yield of Lactobacillus bulgaricus (LB and Streptococcus thermophilus (ST, but also optimized the bacteria proportion of freeze-dried starter culture for yogurt by full factorial experimental design. The results showed as following: the freeze-drying protective agents or anti-freeze factors could enhanced survival rate of LB and ST; the freeze-dried LB and ST powders containing both of anti-freeze factors and freeze-drying protective agents had higher viable count and freeze-drying survival rate that were 84.7% and 79.7% respectively; In terms of fermentation performance, the best group of freeze-dried starter for yogurt was the compound of LB3 and ST2.

  11. Evaluating the treatment of obstructive sleep apnea comorbid with insomnia disorder using an incomplete factorial design.

    Science.gov (United States)

    Crawford, Megan R; Turner, Arlener D; Wyatt, James K; Fogg, Louis F; Ong, Jason C

    2016-03-01

    Chronic insomnia disorder is a prevalent condition and a significant proportion of these individuals also have obstructive sleep apnea (OSA). These two sleep disorders have distinct pathophysiology and are managed with different treatment approaches. High comorbidity rates have been a catalyst for emerging studies examining multidisciplinary treatment for OSA comorbid with insomnia disorder. In this article, we describe a randomized clinical trial of cognitive behavioral treatment for insomnia (CBT-I) and positive airway pressure (PAP) for OSA. Participants are randomized to receive one of three treatment combinations. Individuals randomized to treatment Arm A receive sequential treatment beginning with CBT-I followed by PAP, in treatment Arm B CBT-I and PAP are administered concurrently. These treatment arms are compared to a control condition, treatment Arm C, where individuals receive PAP alone. Adopting an incomplete factorial study design will allow us to evaluate the efficacy of multidisciplinary treatment (Arms A & B) versus standard treatment alone (Arm C). In addition, the random allocation of individuals to the two different combined treatment sequences (Arm A and Arm B) will allow us to understand the benefits of the sequential administration of CBT-I and PAP relative to concurrent treatment of PAP and CBT-I. These findings will provide evidence of the clinical benefits of treating insomnia disorder in the context of OSA. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. Enhancing biodegradation of wastewater by microbial consortia with fractional factorial design

    Energy Technology Data Exchange (ETDEWEB)

    Chen Yuancai [State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, 510640, Guangdong (China); Lin Chejen, E-mail: Jerry.Lin@lamar.edu [Department of Civil Engineering, Lamar University, Beaumont, TX 77710-0024 (United States); School of Environmental Science and Engineering, South China University of Technology, Guangzhou, 510006, Guangdong (China); Jones, Gavin [Texas Research Institute for Environmental Studies, Sam Houston State University, Huntsville, TX 77341-2506 (United States); Fu Shiyu; Zhan Huaiyu [State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, 510640, Guangdong (China)

    2009-11-15

    Batch experiments were conducted on the degradation of synthetic and municipal wastewater by six different strains, i.e., Agrobacterium sp., Bacillus sp., Enterobacter cloacae, Gordonia, Pseudomonas stutzeri, Pseudomonas putida. By applying a fractional factorial design (FFD) of experiments, the influence of each strain and their interactions were quantified. An empirical model predicting the treatment efficiency was built based on the results of the FFD experiments with an R{sup 2} value of 99.39%. For single strain, Enterobacter cloacae, Gordonia and P. putida (p = 0.008, 0.009 and 0.023, respectively) showed significant enhancement on organic removal in the synthetic wastewater. Positive interaction from Enterobacter cloacae, Gordonia (p = 0.046) was found, indicating that syntrophic interaction existed, and their coexistence can improve total organic carbon (TOC) degradation. Verification experiments were performed to evaluate the effect of bioaugmentation by introducing three selected strains into an activated sludge reactor for treating municipal wastewater. The removal efficiency of TOC with the bioaugmentation was increased from 67-72% to 80-84% at an influent TOC concentration of 200 mg/L. The results derived from this study indicate that the FFD is a useful screening tool for optimizing the microbial community to enhance treatment efficiency.

  13. Enhancing biodegradation of wastewater by microbial consortia with fractional factorial design

    International Nuclear Information System (INIS)

    Chen Yuancai; Lin Chejen; Jones, Gavin; Fu Shiyu; Zhan Huaiyu

    2009-01-01

    Batch experiments were conducted on the degradation of synthetic and municipal wastewater by six different strains, i.e., Agrobacterium sp., Bacillus sp., Enterobacter cloacae, Gordonia, Pseudomonas stutzeri, Pseudomonas putida. By applying a fractional factorial design (FFD) of experiments, the influence of each strain and their interactions were quantified. An empirical model predicting the treatment efficiency was built based on the results of the FFD experiments with an R 2 value of 99.39%. For single strain, Enterobacter cloacae, Gordonia and P. putida (p = 0.008, 0.009 and 0.023, respectively) showed significant enhancement on organic removal in the synthetic wastewater. Positive interaction from Enterobacter cloacae, Gordonia (p = 0.046) was found, indicating that syntrophic interaction existed, and their coexistence can improve total organic carbon (TOC) degradation. Verification experiments were performed to evaluate the effect of bioaugmentation by introducing three selected strains into an activated sludge reactor for treating municipal wastewater. The removal efficiency of TOC with the bioaugmentation was increased from 67-72% to 80-84% at an influent TOC concentration of 200 mg/L. The results derived from this study indicate that the FFD is a useful screening tool for optimizing the microbial community to enhance treatment efficiency.

  14. Optimization of cardiovascular stent against restenosis: factorial design-based statistical analysis of polymer coating conditions.

    Directory of Open Access Journals (Sweden)

    Gayathri Acharya

    Full Text Available The objective of this study was to optimize the physicodynamic conditions of polymeric system as a coating substrate for drug eluting stents against restenosis. As Nitric Oxide (NO has multifunctional activities, such as regulating blood flow and pressure, and influencing thrombus formation, a continuous and spatiotemporal delivery of NO loaded in the polymer based nanoparticles could be a viable option to reduce and prevent restenosis. To identify the most suitable carrier for S-Nitrosoglutathione (GSNO, a NO prodrug, stents were coated with various polymers, such as poly (lactic-co-glycolic acid (PLGA, polyethylene glycol (PEG and polycaprolactone (PCL, using solvent evaporation technique. Full factorial design was used to evaluate the effects of the formulation variables in polymer-based stent coatings on the GSNO release rate and weight loss rate. The least square regression model was used for data analysis in the optimization process. The polymer-coated stents were further assessed with Differential scanning calorimetry (DSC, Fourier transform infrared spectroscopy analysis (FTIR, Scanning electron microscopy (SEM images and platelet adhesion studies. Stents coated with PCL matrix displayed more sustained and controlled drug release profiles than those coated with PLGA and PEG. Stents coated with PCL matrix showed the least platelet adhesion rate. Subsequently, stents coated with PCL matrix were subjected to the further optimization processes for improvement of surface morphology and enhancement of the drug release duration. The results of this study demonstrated that PCL matrix containing GSNO is a promising system for stent surface coating against restenosis.

  15. Compatible validated spectrofluorimetric and spectrophotometric methods for determination of vildagliptin and saxagliptin by factorial design experiments

    Science.gov (United States)

    Abdel-Aziz, Omar; Ayad, Miriam F.; Tadros, Mariam M.

    2015-04-01

    Simple, selective and reproducible spectrofluorimetric and spectrophotometric methods have been developed for the determination of vildagliptin and saxagliptin in bulk and their pharmaceutical dosage forms. The first proposed spectrofluorimetric method is based on the dansylation reaction of the amino group of vildagliptin with dansyl chloride to form a highly fluorescent product. The formed product was measured spectrofluorimetrically at 455 nm after excitation at 345 nm. Beer's law was obeyed in a concentration range of 100-600 μg ml-1. The second proposed spectrophotometric method is based on the charge transfer complex of saxagliptin with tetrachloro-1,4-benzoquinone (p-chloranil). The formed charge transfer complex was measured spectrophotometrically at 530 nm. Beer's law was obeyed in a concentration range of 100-850 μg ml-1. The third proposed spectrophotometric method is based on the condensation reaction of the primary amino group of saxagliptin with formaldehyde and acetyl acetone to form a yellow colored product known as Hantzsch reaction, measured at 342.5 nm. Beer's law was obeyed in a concentration range of 50-300 μg ml-1. All the variables were studied to optimize the reactions' conditions using factorial design. The developed methods were validated and proved to be specific and accurate for quality control of vildagliptin and saxagliptin in their pharmaceutical dosage forms.

  16. Improvement of biomass production and glucoamylase activity by Candida famata using factorial design.

    Science.gov (United States)

    Mosbah, Habib; Aissa, Imen; Hassad, Nahla; Farh, Dhaker; Bakhrouf, Amina; Achour, Sami

    2016-07-01

    To improve biomass production and glucoamylase activity (GA) by Candida famata, culture conditions were optimized. A 2(3) full factorial design (FFD) with a response surface model was used to evaluate the effects and interactions of pH (X1 ), time of cultivation (X2 ), and starch concentration (X3 ) on the biomass production and enzyme activity. A total of 16 experiments were conducted toward the construction of an empiric model and a first-order equation. It was found that all factors (X1 , X2 , and X3 ) and their interactions were significant at a certain confidence level (P production and GA of C. famata. Under this optimized medium, the experimental biomass production and GA obtained were 1.8 ± 0.54 g/L and 0.078 ± 0.012 µmol/L/Min, about 1.5- and 1.8-fold, respectively, higher than those in basal medium. The (R(2) ) coefficients obtained were 0.997 and 0.990, indicating an adequate degree of reliability in the model. Approximately 99% of validity of the predicted value was achieved. © 2015 International Union of Biochemistry and Molecular Biology, Inc.

  17. Design of a Low Cost Smart Dryer Temperature Measurement System for Tea Factories

    Directory of Open Access Journals (Sweden)

    Utpal SARMA

    2009-09-01

    Full Text Available This paper presents the design of a low cost smart dryer temperature measurement system for Tea Factories using K-type Thermocouple implementing linearization polynomial. The thermo emf is amplified by an instrumentation amplifier having high CMRR (106 dB and high input impedance (1012 Ohm. The analog signal is converted to digital form with the help of an SPI compatible 12-bit ADC. Data acquisition and transmission is done with an 8- bit microcontroller. As the dependence of thermo emf on temperature is not linear hence it is fitted with a polynomial. NIST data for K-type TC is taken as a standard for this fitting. The error with linear fit and polynomial fit is also presented. The digital data is corrected according to the polynomial and sent to a PC located at a remote control room for monitoring and data logging via RS232C communication. The performance of the entire system is discussed in the paper.

  18. Mucoadhesive Hydrogel Films of Econazole Nitrate: Formulation and Optimization Using Factorial Design

    Directory of Open Access Journals (Sweden)

    Balaram Gajra

    2014-01-01

    Full Text Available The mucoadhesive hydrogel film was prepared and optimized for the purpose of local drug delivery to oral cavity for the treatment of oral Candidiasis. The mucoadhesive hydrogel film was prepared with the poly(vinyl alcohol by freeze/thaw crosslinking technique. 32 full factorial design was employed to optimize the formulation. Number of freeze/thaw cycles (4, 6, and 8 cycles and the concentration of the poly(vinyl alcohol (10, 15, and 20% were used as the independent variables whereas time required for 50% drug release, cumulative percent of drug release at 8th hour, and “k” of zero order equation were used as the dependent variables. The films were evaluated for mucoadhesive strength, in vitro residence time, swelling study, in vitro drug release, and effectiveness against Candida albicans. The concentration of poly(vinyl alcohol and the number of freeze/thaw cycles both decrease the drug release rate. Mucoadhesive hydrogel film with 15% poly(vinyl alcohol and 7 freeze/thaw cycles was optimized. The optimized batch exhibited the sustained release of drug and the antifungal studies revealed that the drug released from the film could inhibit the growth of Candida albicans for 12 hours.

  19. Analysis of semi-solid processing for metal matrix composite synthesis using factorial design

    Directory of Open Access Journals (Sweden)

    Kratus Ranieri

    2012-02-01

    Full Text Available The main goal in this work is to conduct a quantitative analysis of the mechanical stir casting process for obtaining particulate metal matrix composites. A combined route of stirring at semi-solid state followed by stirring at liquid state is proposed. A fractional factorial design was developed to investigate the influence and interactions of factors as: time, rotation, initial fraction and particle size, on the incorporated fraction. The best incorporations were obtained with all factors at high levels, as well as that very long stirring periods have no strong influence being particle size and rotation the most important factors on the incorporated fraction. Particle wetting occurs during stirring at semi-solid state, highlighting the importance of the interactions between particles and the alloy globularized phase. The role of the alloying element Mg as a wettability-promoting agent is discussed. The shear forces resulting from the stirring system is emphasized and understood as the effect of rotation itself added to the propeller blade geometry.

  20. Benzocaine loaded biodegradable poly-(D,L-lactide-co-glycolide) nanocapsules: factorial design and characterization

    International Nuclear Information System (INIS)

    Morales Moraes, Carolina; Prado de Matos, Angelica; Paula, Eneida de; Rosa, Andre Henrique; Fernandes Fraceto, Leonardo

    2009-01-01

    Local anesthetics are able to induce pain relief since they bind to the sodium channel of excitable membranes, blocking the influx of sodium ions and the propagation of the nervous impulse. Benzocaine (BZC) is a local anesthetic that presents limited application in topical formulations due to its low water-solubility. This study aimed to develop polymeric nanocapsules as a drug delivery system for the local anesthetic benzocaine (BZC). To do so, BZC loaded poly(D,L-lactide-co-glycolide) (PLGA) nanocapsules were prepared using the nanoprecipitation method and were characterized. The factorial experimental design was used to study the influence of four different independent variables on response to nanocapsules drug loading. The physical characteristics of PLGA nanocapsules were evaluated by analyzing the particle size, the polydispersion index and the zeta potential, using a particle size analyzer. The results of the optimized formulation showed a size distribution with a polydispersity index of 0.12, an average diameter of 123 nm, zeta potential of -33.6 mV and a drug loading of more than 69%. The release profiles showed a significant difference in the release behavior for the pure drug in solution when compared with that containing benzocaine loaded PLGA nanocapsules. Thus, the prepared nanocapsules described here may be of clinical importance in both the processes of stabilization and delivery of benzocaine for pain treatment.

  1. Benzocaine loaded biodegradable poly-(D,L-lactide-co-glycolide) nanocapsules: factorial design and characterization

    Energy Technology Data Exchange (ETDEWEB)

    Morales Moraes, Carolina; Prado de Matos, Angelica; Paula, Eneida de [Department of Biochemistry, Institute of Biology, State University of Campinas, Campinas, SP (Brazil); Rosa, Andre Henrique [Department of Environmental Engineering, State University of Sao Paulo, Sorocaba, Sao Paulo (Brazil); Fernandes Fraceto, Leonardo, E-mail: leonardo@sorocaba.unesp.b [Department of Biochemistry, Institute of Biology, State University of Campinas, Campinas, SP (Brazil); Department of Environmental Engineering, State University of Sao Paulo, Sorocaba, Sao Paulo (Brazil)

    2009-12-15

    Local anesthetics are able to induce pain relief since they bind to the sodium channel of excitable membranes, blocking the influx of sodium ions and the propagation of the nervous impulse. Benzocaine (BZC) is a local anesthetic that presents limited application in topical formulations due to its low water-solubility. This study aimed to develop polymeric nanocapsules as a drug delivery system for the local anesthetic benzocaine (BZC). To do so, BZC loaded poly(D,L-lactide-co-glycolide) (PLGA) nanocapsules were prepared using the nanoprecipitation method and were characterized. The factorial experimental design was used to study the influence of four different independent variables on response to nanocapsules drug loading. The physical characteristics of PLGA nanocapsules were evaluated by analyzing the particle size, the polydispersion index and the zeta potential, using a particle size analyzer. The results of the optimized formulation showed a size distribution with a polydispersity index of 0.12, an average diameter of 123 nm, zeta potential of -33.6 mV and a drug loading of more than 69%. The release profiles showed a significant difference in the release behavior for the pure drug in solution when compared with that containing benzocaine loaded PLGA nanocapsules. Thus, the prepared nanocapsules described here may be of clinical importance in both the processes of stabilization and delivery of benzocaine for pain treatment.

  2. Factorial experimental design for recovering heavy metals from sludge with ion-exchange resin

    International Nuclear Information System (INIS)

    Lee, I.H.; Kuan, Y.-C.; Chern, J.-M.

    2006-01-01

    Wastewaters containing heavy metals are usually treated by chemical precipitation method in Taiwan. This method can remove heavy metals form wastewaters efficiently, but the resultant heavy metal sludge is classified as hazardous solid waste and becomes another environmental problem. If we can remove heavy metals from sludge, it becomes non-hazardous waste and the treatment cost can be greatly reduced. This study aims at using ion-exchange resin to remove heavy metals such as copper, zinc, cadmium, and chromium from sludge generated by a PCB manufacturing plant. Factorial experimental design methodology was used to study the heavy metal removal efficiency. The total metal concentrations in the sludge, resin, and solution phases were measured respectively after 30 min reaction with varying leaching agents (citric acid and nitric acid); ion-exchange resins (Amberlite IRC-718 and IR-120), and temperatures (50 and 70 deg. C). The experimental results and statistical analysis show that a stronger leaching acid and a higher temperature both favor lower heavy metal residues in the sludge. Two-factors and even three-factor interaction effects on the heavy metal sorption in the resin phase are not negligible. The ion-exchange resin plays an important role in the sludge extraction or metal recovery. Empirical regression models were also obtained and used to predict the heavy metal profiles with satisfactory results

  3. Study on bio-ethanol production from oil palm (Elaies Guineensis) trunks sap using factorial design

    Energy Technology Data Exchange (ETDEWEB)

    Norhazimah, A. H.; Che Ku, M. Faizala [Faculty of Chemical and Natural Resources Engineering, Universiti Malaysia Pahang (Malaysia)], email: amfaizal@ump.edu.my

    2011-07-01

    Oil palm (Elaies Guineensis) trunks (OPT), a waste generated from the re-plantation of oil palm trees for palm oil production, contain useful fermentable sugar for bio-ethanol production, and are a very important biomass material for future energy production. The fermentation usually can be affected along several parameters: temperature, pH, agitation rate, percentage inoculums, time of incubation, nitrogen sources, age of the inoculums and other chemical and physical factors. Since identifying all the effects of a particular factor on the fermentation process is impractical for reasons of time and cost, the approach of this study was based on a two-level five-factor (25) full factorial design (FFD) in order to identify the independent parameters for screening experiment purposes and determine the range of levels of the factor as well as the regions for optimization. The results from this study showed that the most influential principal factors affecting ethanol concentration and productivity were temperature, followed by initial pH and agitation rate.

  4. Ammonia-nitrogen and Phosphate Reduction by Bio-Filter using Factorial Design

    Science.gov (United States)

    Kasmuri, Norhafezah; Ashikin Mat Damin, Nur; Omar, Megawati

    2018-02-01

    Untreated landfill leachate is known to have endangered the environment. As such new treatment must be sought to ensure its cost-effective and sustainable treatment. Thus this paper reports the effectiveness of bio-filter to remove pollutants. In this research, the reduction of nutrients concentration was evaluated in two conditions: using bio-filter and without bio-filter. Synthetic wastewater was used in the batch culture. It was conducted within 21 days in the initial mediums of 100 mg/L ammonia-nitrogen. The nitrification medium consisted of 100 mg/L of ammonia-nitrogen while the nitrite assay had none. The petri dish experiment was also conducted to observe the existence of any colony. The results showed 22% of ammonia- nitrogen reduction and 33% phosphate in the nitrification medium with the bio-filter. The outcome showed that the bio-filter was capable to reduce the concentration of pollutants by retaining the slow growing bacteria (AOB and NOB) on the plastic carrier surface. The factorial design was applied to study the effect of the initial ammonia-nitrogen concentration and duration on nitrite-nitrogen removal. Finally, a regression equation was produced to predict the rate of nitrite-nitrogen removal without conducting extended experiments and to reduce the number of trials experiment.

  5. Effect of polymer type on characteristics of buccal tablets using factorial design

    Directory of Open Access Journals (Sweden)

    O. Esim

    2018-01-01

    Full Text Available A two factor three level factorial design was used to investigate the effects of carbopol and cationic hydrophilic polymers which have a common use in buccal drug formulations. Statistical models with interaction terms were derived to evaluate influence of carbopol (X1 and chitosan (X2 on tablet disintegration (Y1 and dissolution (Y2, mechanical properties (Y3, swelling (Y4. Tablet disintegration studies were carried out using two different pH environments within buccal region pH limits and also two different commonly used dissolution methods for buccal tablets were also investigated to compare the effect of polymer type on dissolution. Polymer type and ratio affect the characteristics of the buccal tablets due to their different physicochemical behavior at buccal pH. Also significant variances between dissolution profiles for buccal tablets, using either USP Paddle or flow through cell methods were found. These results indicate that both polymer type and ratio as well as combination of them effects the drug behavior in different ways. Keywords: Buccal tablet, Hydrophilic matrix, Effect of polymer, Carbopol, Chitosan

  6. Rapid Determination of Protein Solubility and Stability Conditions for NMR Studies Using Incomplete Factorial Design

    International Nuclear Information System (INIS)

    Ducat, Thierry; Declerck, Nathalie; Gostan, Thierry; Kochoyan, Michel; Demene, Helene

    2006-01-01

    Sample preparation constitutes a crucial and limiting step in structural studies of proteins by NMR. The determination of the solubility and stability (SAS) conditions of biomolecules at millimolar concentrations stays today empirical and hence time- and material-consuming. Only few studies have been recently done in this field and they have highlighted the interest of using crystallogenesis tools to optimise sample conditions. In this study, we have adapted a method based on incomplete factorial design and making use of crystallisation plates to quantify the influence of physico-chemical parameters such as buffer pH and salts on protein SAS. A description of the experimental set up and an evaluation of the method are given by case studies on two functional domains from the bacterial regulatory protein LicT as well as two other proteins. Using this method, we could rapidly determine optimised conditions for extracting soluble proteins from bacterial cells and for preparing purified protein samples sufficiently concentrated and stable for NMR characterisation. The drastic reduction in the time and number of experiments required for searching protein SAS conditions makes this method particularly well-adapted for a systematic investigation on a large range of physico-chemical parameters

  7. A comparison of the performance of compact neutrino detector designs for nuclear reactor safeguards and monitoring

    International Nuclear Information System (INIS)

    Reyna, D. E.; McKeown, R. W.

    2006-01-01

    There has been an increasing interest in the monitoring of nuclear fuel for power reactors by detecting the anti-neutrinos produced during operation. Small liquid scintillator detectors have already demonstrated sensitivity to operational power levels, but more sensitive monitoring requires improvements in the efficiency and uniformity of these detectors. In this work, we use a montecarlo simulation to investigate the detector performance of four different detector configurations. Based on the analysis of neutron detection efficiency and positron energy response, we find that the optimal detector design will depend on the goals and restrictions of the specific installation or application. We have attempted to present the relevant information so that future detector development can proceed in a profitable direction

  8. Full factorial design optimization of anti-inflammatory drug release by PCL–PEG–PCL microspheres

    Energy Technology Data Exchange (ETDEWEB)

    Azouz, L' Hachemi, E-mail: azouz.chimie@gmail.com [Laboratoire des Matériaux Organiques (LMO), Faculté des Sciences Exactes, Département de Chimie, Université de Bejaia, 06000 Bejaia Algérie (Algeria); Dahmoune, Farid, E-mail: farid.dahmoune@yahoo.fr [Laboratoire de Biomathématiques, Biophysique, Biochimie et Scientométrie (L3BS-Bejaia), Faculté des Sciences de la Nature et de la Vie et des Sciences de la Terre, Université de Bouira 10000 Bouira (Algeria); Rezgui, Farouk, E-mail: rezgui-farouk@netcourrier.com [Laboratoire des Matériaux Organiques (LMO), Faculté de Technologie, Département de Génie des Procédés, Université de Bejaia, 06000 Bejaia (Algeria); G' Sell, Christian, E-mail: gsell.christian@univ-lorraine.fr [Université de Lorraine, Pôle scientifique M4, Institut Jean Lamour - UMR CNRS-UL 7198, Département SI2M, 54000 Nancy (France)

    2016-01-01

    A biodegradable triblock poly(ε-caprolactone)–poly(ethylene glycol)–poly(ε-caprolactone) copolymer was successfully synthesized by ring-opening polymerization of ε-caprolactone, and was characterized by intrinsic viscosimetry, {sup 1}H nuclear magnetic resonance, infrared spectroscopy and X-ray diffraction. Copolymer microparticles loaded with ibuprofen were prepared by an oil-in-water (o/w) emulsion solvent evaporation process. They were carefully weighted and characterized through their zeta potential. In this work, 4 selected process parameters (shaking speed X{sub 1}, time of contact X{sub 2}, poly(vinyl alcohol) concentration X{sub 3}, and ibuprofen concentration X{sub 4}) were adjusted at 2 different values. For each of the 16 experimental conditions, repeated twice, the drug encapsulation efficiency of the microspheres was determined, according to the following definition: EE (X{sub 1}, X{sub 2}, X{sub 3}, X{sub 4}) = mass of encapsulated ibuprofen / total weight of ibuprofen. A “full factorial design method” was applied to analyze the results statistically according to a polynomial fit and to determine the optimal conditions for the microencapsulation of the ibuprofen through an accurate statistical protocol. The microparticles obtained exhibit a spherical shape as shown by electron microscopy. - Highlights: • PCEC copolymer was synthesized by ring-opening polymerization of ε-caprolactone. • 2{sup 4} experimental design was used to optimize the IBF encapsulation efficiency (EE). • 88.86% of ibuprofen (IBF) was encapsulated in PCEC microspheres. • EE significantly decreases with increasing shaking speed (antagonist effect). • EE significantly increases with increasing IBF concentration (synergetic effect).

  9. Full factorial design optimization of anti-inflammatory drug release by PCL–PEG–PCL microspheres

    International Nuclear Information System (INIS)

    Azouz, L'Hachemi; Dahmoune, Farid; Rezgui, Farouk; G'Sell, Christian

    2016-01-01

    A biodegradable triblock poly(ε-caprolactone)–poly(ethylene glycol)–poly(ε-caprolactone) copolymer was successfully synthesized by ring-opening polymerization of ε-caprolactone, and was characterized by intrinsic viscosimetry, 1 H nuclear magnetic resonance, infrared spectroscopy and X-ray diffraction. Copolymer microparticles loaded with ibuprofen were prepared by an oil-in-water (o/w) emulsion solvent evaporation process. They were carefully weighted and characterized through their zeta potential. In this work, 4 selected process parameters (shaking speed X 1 , time of contact X 2 , poly(vinyl alcohol) concentration X 3 , and ibuprofen concentration X 4 ) were adjusted at 2 different values. For each of the 16 experimental conditions, repeated twice, the drug encapsulation efficiency of the microspheres was determined, according to the following definition: EE (X 1 , X 2 , X 3 , X 4 ) = mass of encapsulated ibuprofen / total weight of ibuprofen. A “full factorial design method” was applied to analyze the results statistically according to a polynomial fit and to determine the optimal conditions for the microencapsulation of the ibuprofen through an accurate statistical protocol. The microparticles obtained exhibit a spherical shape as shown by electron microscopy. - Highlights: • PCEC copolymer was synthesized by ring-opening polymerization of ε-caprolactone. • 2 4 experimental design was used to optimize the IBF encapsulation efficiency (EE). • 88.86% of ibuprofen (IBF) was encapsulated in PCEC microspheres. • EE significantly decreases with increasing shaking speed (antagonist effect). • EE significantly increases with increasing IBF concentration (synergetic effect).

  10. Fractional factorial plans

    CERN Document Server

    Dey, Aloke

    2009-01-01

    A one-stop reference to fractional factorials and related orthogonal arrays.Presenting one of the most dynamic areas of statistical research, this book offers a systematic, rigorous, and up-to-date treatment of fractional factorial designs and related combinatorial mathematics. Leading statisticians Aloke Dey and Rahul Mukerjee consolidate vast amounts of material from the professional literature--expertly weaving fractional replication, orthogonal arrays, and optimality aspects. They develop the basic theory of fractional factorials using the calculus of factorial arrangements, thereby providing a unified approach to the study of fractional factorial plans. An indispensable guide for statisticians in research and industry as well as for graduate students, Fractional Factorial Plans features: * Construction procedures of symmetric and asymmetric orthogonal arrays. * Many up-to-date research results on nonexistence. * A chapter on optimal fractional factorials not based on orthogonal arrays. * Trend-free plans...

  11. Statistical optimization of the growth factors for Chaetoceros neogracile using fractional factorial design and central composite design.

    Science.gov (United States)

    Jeong, Sung-Eun; Park, Jae-Kweon; Kim, Jeong-Dong; Chang, In-Jeong; Hong, Seong-Joo; Kang, Sung-Ho; Lee, Choul-Gyun

    2008-12-01

    Statistical experimental designs; involving (i) a fractional factorial design (FFD) and (ii) a central composite design (CCD) were applied to optimize the culture medium constituents for production of a unique antifreeze protein by the Antartic microalgae Chaetoceros neogracile. The results of the FFD suggested that NaCl, KCl, MgCl2, and Na2SiO3 were significant variables that highly influenced the growth rate and biomass production. The optimum culture medium for the production of an antifreeze protein from C. neogracile was found to be Kalleampersandrsquor;s artificial seawater, pH of 7.0ampersandplusmn;0.5, consisting of 28.566 g/l of NaCl, 3.887 g/l of MgCl2, 1.787 g/l of MgSO4, 1.308 g/l of CaSO4, 0.832 g/l of K2SO4, 0.124 g/l of CaCO3, 0.103 g/l of KBr, 0.0288 g/l of SrSO4, and 0.0282 g/l of H3BO3. The antifreeze activity significantly increased after cells were treated with cold shock (at -5oC) for 14 h. To the best of our knowledge, this is the first report demonstrating an antifreeze-like protein of C. neogracile.

  12. MINOS Sterile Neutrino Search

    Energy Technology Data Exchange (ETDEWEB)

    Koskinen, David Jason [Univ. College London, Bloomsbury (United Kingdom)

    2009-02-01

    The Main Injector Neutrino Oscillation Search (MINOS) is a long-baseline accelerator neutrino experiment designed to measure properties of neutrino oscillation. Using a high intensity muon neutrino beam, produced by the Neutrinos at Main Injector (NuMI) complex at Fermilab, MINOS makes two measurements of neutrino interactions. The first measurement is made using the Near Detector situated at Fermilab and the second is made using the Far Detector located in the Soudan Underground laboratory in northern Minnesota. The primary goal of MINOS is to verify, and measure the properties of, neutrino oscillation between the two detectors using the v μ→ Vτ transition. A complementary measurement can be made to search for the existence of sterile neutrinos; an oft theorized, but experimentally unvalidated particle. The following thesis will show the results of a sterile neutrino search using MINOS RunI and RunII data totaling ~2.5 x 1020 protons on target. Due to the theoretical nature of sterile neutrinos, complete formalism that covers transition probabilities for the three known active states with the addition of a sterile state is also presented.

  13. Neutrino physics

    International Nuclear Information System (INIS)

    Gil-Botella, I.

    2011-01-01

    The fundamental properties of neutrinos are reviewed in these lectures. The first part is focused on the basic characteristics of neutrinos in the Standard Model and how neutrinos are detected. Neutrino masses and oscillations are introduced and a summary of the most important experimental results on neutrino oscillations to date is provided. Then, present and future experimental proposals are discussed, including new precision reactor and accelerator experiments. Finally, different approaches for measuring the neutrino mass and the nature (Majorana or Dirac), of neutrinos are reviewed. The detection of neutrinos from supernovae explosions and the information that this measurement can provide are also summarized at the end. (author)

  14. Engineering microbial cell factories for the production of plant natural products: from design principles to industrial-scale production.

    Science.gov (United States)

    Liu, Xiaonan; Ding, Wentao; Jiang, Huifeng

    2017-07-19

    Plant natural products (PNPs) are widely used as pharmaceuticals, nutraceuticals, seasonings, pigments, etc., with a huge commercial value on the global market. However, most of these PNPs are still being extracted from plants. A resource-conserving and environment-friendly synthesis route for PNPs that utilizes microbial cell factories has attracted increasing attention since the 1940s. However, at the present only a handful of PNPs are being produced by microbial cell factories at an industrial scale, and there are still many challenges in their large-scale application. One of the challenges is that most biosynthetic pathways of PNPs are still unknown, which largely limits the number of candidate PNPs for heterologous microbial production. Another challenge is that the metabolic fluxes toward the target products in microbial hosts are often hindered by poor precursor supply, low catalytic activity of enzymes and obstructed product transport. Consequently, despite intensive studies on the metabolic engineering of microbial hosts, the fermentation costs of most heterologously produced PNPs are still too high for industrial-scale production. In this paper, we review several aspects of PNP production in microbial cell factories, including important design principles and recent progress in pathway mining and metabolic engineering. In addition, implemented cases of industrial-scale production of PNPs in microbial cell factories are also highlighted.

  15. Factorial design applied to the optimization of lipid composition of topical antiherpetic nanoemulsions containing isoflavone genistein

    Directory of Open Access Journals (Sweden)

    Argenta DF

    2014-10-01

    Full Text Available Débora Fretes Argenta,1 Cristiane Bastos de Mattos,1 Fabíola Dallarosa Misturini,1 Leticia Scherer Koester,1 Valquiria Linck Bassani,1 Cláudia Maria Oliveira Simões,2 Helder Ferreira Teixeira1 1Programa de Pós-graduação em Ciências Farmacêuticas da Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; 2Programa de Pós-graduação em Farmácia da Universidade Federal de Santa Catarina, Florianópolis, Brazil Abstract: The aim of this study was to optimize topical nanoemulsions containing genistein, by means of a 23 full factorial design based on physicochemical properties and skin retention. The experimental arrangement was constructed using oil type (isopropyl myristate or castor oil, phospholipid type (distearoylphosphatidylcholine [DSPC] or dioleylphosphaditylcholine [DOPC], and ionic cosurfactant type (oleic acid or oleylamine as independent variables. The analysis of variance showed effect of third order for particle size, polydispersity index, and skin retention of genistein. Nanoemulsions composed of isopropyl myristate/DOPC/oleylamine showed the smallest diameter and highest genistein amount in porcine ear skin whereas the formulation composed of isopropyl myristate/DSPC/oleylamine exhibited the lowest polydispersity index. Thus, these two formulations were selected for further studies. The formulations presented positive ζ potential values (>25 mV and genistein content close to 100% (at 1 mg/mL. The incorporation of genistein in nanoemulsions significantly increased the retention of this isoflavone in epidermis and dermis, especially when the formulation composed by isopropyl myristate/DOPC/oleylamine was used. These results were supported by confocal images. Such formulations exhibited antiherpetic activity in vitro against herpes simplex virus 1 (strain KOS and herpes simplex virus 22 (strain 333. Taken together, the results show that the genistein-loaded nanoemulsions developed in this study are promising

  16. Turbo-extraction of glycosides from Stevia rebaudiana using a fractional factorial design

    Directory of Open Access Journals (Sweden)

    Paula M. Martins

    Full Text Available ABSTRACT Stevia rebaudiana (Bertoni Bertoni, Asteraceae, leaf extract has recently called the attention of food industry as a proposal for natural sweetener. The sweet flavor is attributed to the glycosides, in especial stevioside and rebaudioside A, which are the plant main chemical markers. The aim of the work reported here was to optimize the turbo-extraction of stevia leaves using water, ethanol 70% and 90% (w/w as green solvents. A 25-2 factorial design was applied to study the linear effects of the drug size, solvent to drug ratio, temperature, time and also the turbolysis speed on the extraction of glycosides. The glycosides exhaustive extraction showed that ethanol 70% gave better results and was used for turbo-extraction. The stevioside and rebaudioside A contents were quantified by a validated method by high performance liquid chromatographic with photodiode array detector. The contents of stevioside and rebaudioside A in fluid extract increased with the drug size, but decreased at high shearing speeds and solvent to drug ratio, while their yields decreased at higher temperature and were not affected by turbo speed. An increase in solvent to drug ratio reduced significantly the glycosides percent in dried extract. Optimal solution for S. rebaudiana leaves turbo-extraction was determined by desirability functions. The optimal extraction condition corresponded to drug size of 780 µm, solvent to drug ratio of 10, extraction time of 18 min; temperature of 23 ºC and turbo speed of 20,000 rpm, resulting in yields of 4.98% and 2.70%, for stevioside and rebaudioside A, respectively. These yields are comparable to the ones recently published for dynamic maceration, but with the advantage of shorter extraction times. This work demonstrates that turbolysis is promising for S. rebaudiana glycosides extraction and stimulate new research on the purification of these extracts, which may become an interesting source of income for developing

  17. Development and optimization of enteric coated mucoadhesive microspheres of duloxetine hydrochloride using 32 full factorial design

    Science.gov (United States)

    Setia, Anupama; Kansal, Sahil; Goyal, Naveen

    2013-01-01

    Background: Microspheres constitute an important part of oral drug delivery system by virtue of their small size and efficient carrier capacity. However, the success of these microspheres is limited due to their short residence time at the site of absorption. Objective: The objective of the present study was to formulate and systematically evaluate in vitro performance of enteric coated mucoadhesive microspheres of duloxetine hydrochloride (DLX), an acid labile drug. Materials and Methods: DLX microspheres were prepared by simple emulsification phase separation technique using chitosan as carrier and glutaraldehyde as a cross-linking agent. Microspheres prepared were coated with eudragit L-100 using an oil-in-oil solvent evaporation method. Eudragit L-100was used as enteric coating polymer with the aim to release the drug in small intestine The microspheres prepared were characterized by particle size, entrapment efficiency, swelling index (SI), mucoadhesion time, in vitro drug release and surface morphology. A 32 full factorial design was employed to study the effect of independent variables polymer-to-drug ratio (X1) and stirring speed (X2) on dependent variables, particle size, entrapment efficiency, SI, in vitro mucoadhesion and drug release up to 24 h (t24). Results: Microspheres formed were discrete, spherical and free flowing. The microspheres exhibited good mucoadhesive property and also showed high percentage entrapment efficiency. The microspheres were able to sustain the drug release up to 24 h. Conclusion: Thus, the prepared enteric coated mucoadhesive microspheres may prove to be a potential controlled release formulation of DLX for oral administration. PMID:24167786

  18. Optimizing conditions for the development process of the sponge liquid bread mold through a factorial design

    Directory of Open Access Journals (Sweden)

    Claudia Marcela Quintero Gil

    2008-06-01

    Full Text Available The bread in its many forms is one of the oldest and most widely food consumed by humanity, its appearance is not known for sure, but it is presumed that he was in the Middle East, where he began to cultivate wheat. Due to its development in different cultures have been many developments in technology and industry, however all the processes that are designed to make bread have had a common purpose and simple, the conversion of wheat four in a food spongy and appetizing. This objective has been achieved through a series of stages are common as the mixture of water and four with yeast, salt and other ingredients individuals in appropriate proportions; the generation of specific aroma and favor through fermentation and the development a structure of gluten in combination with the application of mechanical energy during the kneading and the subsequent acquisition of a fixed and final structure consistent with a nice color through the baking.To achieve this goal which is based on the fermentation of the baking industry has created the term to refer to a sponge pre whose primary function is precisely to change the favor and aroma and contribute to the development of the mass through changes in the properties rheological properties of the mixture. Among the ingredients of the sponge is drawn to the food for yeast known as (APL that has the primary role of regulating the fermentation through the right mix of ingredients both qualitatively and quantitatively.The study of this combination was raised in this paper using a factorial design of experiments with statistical treatment looking to evaluate the effects of the formulation in combination with the temperature on a response variable called gasification power which indirectly measured the development of the fermentation Liquid sponges that serve as a basis for the preparation of bread mold. The results made it possible to defne a design and the apl an optimum temperature at which the variable response

  19. Neutrino cosmology

    International Nuclear Information System (INIS)

    Berstein, J.

    1984-01-01

    These lectures offer a self-contained review of the role of neutrinos in cosmology. The first part deals with the question 'What is a neutrino.' and describes in a historical context the theoretical ideas and experimental discoveries related to the different types of neutrinos and their properties. The basic differences between the Dirac neutrino and the Majorana neutrino are pointed out and the evidence for different neutrino 'flavours', neutrino mass, and neutrino oscillations is discussed. The second part summarizes current views on cosmology, particularly as they are affected by recent theoretical and experimental advances in high-energy particle physics. Finally, the close relationship between neutrino physics and cosmology is brought out in more detail, to show how cosmological constraints can limit the various theoretical possibilities for neutrinos and, more particularly, how increasing knowledge of neutrino properties can contribute to our understanding of the origin, history, and future of the Universe. The level is that of the beginning graduate student. (orig.)

  20. Evaluation of the use of steelmaking slag as an aggregate in concrete mix: A factorial design approach

    OpenAIRE

    Aljbour Salah H.; Tarawneh Sultan A.; Al-Harahsheh Adnan M.

    2017-01-01

    Slag is investigated towards its potential use as an aggregate in concrete mix production. Full factorial design methodology is applied to study the effect of two process input variables, namely: slag as coarse aggregate and slag as medium aggregate on the properties of concrete mix. Additionally, the interaction between input variables is also examined. Incorporating steel slag aggregate in the concrete mix affected its compressive strength. Enhanced compressive strength concrete mix was obt...

  1. Design and Construction of a High-speed Network Connecting All the Protein Crystallography Beamlines at the Photon Factory

    International Nuclear Information System (INIS)

    Matsugaki, Naohiro; Yamada, Yusuke; Igarashi, Noriyuki; Wakatsuki, Soichi

    2007-01-01

    A private network, physically separated from the facility network, was designed and constructed which covered all the four protein crystallography beamlines at the Photon Factory (PF) and Structural Biology Research Center (SBRC). Connecting all the beamlines in the same network allows for simple authentication and a common working environment for a user who uses multiple beamlines. Giga-bit Ethernet wire-speed was achieved for the communication among the beamlines and SBRC buildings

  2. Particle factories

    International Nuclear Information System (INIS)

    Schindler, Rafe

    1989-01-01

    Physicists' attention is increasingly turning to the high luminosity frontier - providing enough collisions to amass sizable numbers of rare events - to complement the traditional quest for higher energies. This month we cover three areas where projects are now being considered: Phi-factory workshop, PSI Planning for B meson factory, Tau-charm factory

  3. Particle factories

    Energy Technology Data Exchange (ETDEWEB)

    Schindler, Rafe

    1989-07-15

    Physicists' attention is increasingly turning to the high luminosity frontier - providing enough collisions to amass sizable numbers of rare events - to complement the traditional quest for higher energies. This month we cover three areas where projects are now being considered: Phi-factory workshop, PSI Planning for B meson factory, Tau-charm factory.

  4. Neutrino mass?

    International Nuclear Information System (INIS)

    Kayser, B.

    1992-01-01

    After arguing that we should be looking for evidence of neutrino mass, we illustrate the possible consequences of neutrino mass and mixing. We then turn to the question of whether neutrinos are their own antiparticles, and to the process which may answer this question: neutrinoless double beta decay. Next, we review the proposed Mikheyev-Smirnov-Wolfenstein solution to the solar neutrino problem, and discuss models which can generate neutrino electromagnetic moments large enough to play a role in the sun. Finally, we consider how the possible 17 keV neutrino, if real, would fit in with everything we know about neutrinos. (orig.)

  5. Used frying oil biodiesel production: experimental factorial design and multivariate analysis

    Directory of Open Access Journals (Sweden)

    Rosana de Cassia de Souza Schneider

    2009-01-01

    Full Text Available Biodiesel é derivado de fontes renováveis ereduz significativamente as emissões atmosféricas. Pode serobtido de diversos processos, como a alcoolise. Nestetrabalho, o biodiesel foi produzido através da alcoolise doóleo de fritura usado de indústrias de alimentação. Umplanejamento experimental foi utilizado e os produtos dereação foram analisados por cromatografia gasosa (CGespectroscopia na região do infravermelho com acessório dereflexão total atenuada horizontal (IV-HATR e análiseexploratória por análise de componentes principais (PCA eanálise hierárquica de grupos (HCA. De acordo com ascondições analisadas obteve-se alta conversão em ésteresmetílicos. Por IV-HATR, a conversão máxima foi observadaem condições experimentais de temperatura ( 50 e 60°C,concentração de catalisador (0,6 e 1,2% e a 1:8 de relaçãomolar entre óleo e metanol. Também foi possíveldiscriminar por análise quimiométrica, 4 grupos noplanejamento experimental e determinar as melhorescondições para a produção de biodiesel de óleo de friturausado.Abstract Biodiesel is derived from renewable sources and it significantly reduces atmospheric emissions. It can be obtained byseveral processes, such as alcoholysis. In this work, biodiesel was produced through alcoholysis of used frying oil from a cateringbusiness. An experimental factorial design was used and the reaction products were analyzed through gas chromatography (GC,horizontal attenuated total reflection Fourier transform infrared (HATR/FT-IR spectroscopy and exploratory analysis withprincipal component analysis (PCA and hierarchical cluster analysis (HCA. Under the conditions analyzed, a high degree ofconversion to methyl ester was found. As shown by HATR/FT-IR, the maximum conversion was obtained when the experimentalconditions had the temperature ( 50 e 60°C, largest catalyst concentration (0,6 e 1,2% and a 1:8 molar proportion of oil tomethanol. It was possible to discriminate

  6. Application of factorial design for the ab initio study of cis- and trans-1,2 dihaloethylene stabilities

    Directory of Open Access Journals (Sweden)

    Silva João Bosco P. da

    2000-01-01

    Full Text Available The chemometric technique Two Level Factorial Design was used to evaluate the principal and interaction effects of wave function modifications on calculated energy differences (DE between the cis and trans isomers of 1,2-dihaloethylenes, C2H2X2 (X=F and Cl. The factorial profile of DE is quite different for these systems. The addition of polarization and diffuse functions to the basis set have the largest effects in describing cis 1,2-difluoroethylene as the most stable isomer. In contrast electronic correlation, at the MP2 level, and the inclusion of polarization functions in the basis set have the largest effects in describing the cis form as the most stable one in the 1,2-dichloroethylenes. In both systems the interaction effects are smaller than the principal effects.

  7. Neutrino masses and neutrino oscillations

    CERN Document Server

    Di Lella, L

    2000-01-01

    These lectures review direct measurements of neutrino masses and the status of neutrino oscillation searches using both natural neutrino sources (the Sun and cosmic rays interacting in the Earth atmosphere) and artificial neutrinos (produced by nuclear reactors and accelerators). Finally, future experiments and plans are presented. (68 refs).

  8. A tau-charm-factory at Argonne

    International Nuclear Information System (INIS)

    Norem, J.; Repond, J.

    1994-01-01

    In this paper we explore the possibility of building a tau-charm-factory at the Argonne National Laboratory. A tau-charm-factory is an e + e - collider with a center-of-mass energy between 3.0 GeV and 5.0 GeV and a luminosity of at least 1 x 10 33 cm -2 s -1 . Once operational, the facility will produce large samples of τ pairs, charm mesons, and charmonium with either negligible or well understood backgrounds. This will lead to high precision measurements in the second generation quark and the third generation lepton sectors that cannot be done at other facilities. Basic physical properties and processes, such as the tau neutrino mass, rare tau decays, charm decay constants, rare charm meson decays, neutral D 0 -- meson mixing, and many more will be studied with unique precision. An initial design of the collider including the injector system is described. The design shows that a luminosity of at least 1 x 10 33 cm -2 s -1 can be achieved over the entire center-of-mass energy range of the factory

  9. Investigation of the impact of trace elements on anaerobic volatile fatty acid degradation using a fractional factorial experimental design.

    Science.gov (United States)

    Jiang, Ying; Zhang, Yue; Banks, Charles; Heaven, Sonia; Longhurst, Philip

    2017-11-15

    The requirement of trace elements (TE) in anaerobic digestion process is widely documented. However, little is understood regarding the specific requirement of elements and their critical concentrations under different operating conditions such as substrate characterisation and temperature. In this study, a flask batch trial using fractional factorial design is conducted to investigate volatile fatty acids (VFA) anaerobic degradation rate under the influence of the individual and combined effect of six TEs (Co, Ni, Mo, Se, Fe and W). The experiment inoculated with food waste digestate, spiked with sodium acetate and sodium propionate both to 10 g/l. This is followed by the addition of a selection of the six elements in accordance with a 2 6-2 fractional factorial principle. The experiment is conducted in duplicate and the degradation of VFA is regularly monitored. Factorial effect analysis on the experimental results reveals that within these experimental conditions, Se has a key role in promoting the degradation rates of both acetic and propionic acids; Mo and Co are found to have a modest effect on increasing propionic acid degradation rate. It is also revealed that Ni shows some inhibitory effects on VFA degradation, possibly due to its toxicity. Additionally, regression coefficients for the main and second order effects are calculated to establish regression models for VFA degradation. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Neutrino physics

    CERN Document Server

    Hernandez, P.

    2016-01-01

    This is the writeup of the lectures on neutrino physics delivered at various schools: TASI and Trieste in 2013 and the CERN-Latin American School in 2015. The topics discussed in this lecture include: general properties of neutrinos in the SM, the theory of neutrino masses and mixings (Dirac and Majorana), neutrino oscillations both in vacuum and in matter, as well as an overview of the experimental evidence for neutrino masses and of the prospects in neutrino oscillation physics. We also briefly review the relevance of neutri- nos in leptogenesis and in beyond-the-Standard-Model physics.

  11. Neutrino astrophysics

    International Nuclear Information System (INIS)

    Roulet, E.

    2001-01-01

    A general overview of neutrino physics and astrophysics is given, starting with a historical account of the development of our understanding of neutrinos and how they helped to unravel the structure of the Standard Model. We discuss why it is so important to establish if neutrinos are massive and introduce the main scenarios to provide them a mass. The present bounds and the positive indications in favor of non-zero neutrino masses are discussed, including the recent results on atmospheric and solar neutrinos. The major role that neutrinos play in astrophysics and cosmology is illustrated. (author)

  12. Design, manufacture and factory testing of the Ion Source and Extraction Power Supplies for the SPIDER experiment

    International Nuclear Information System (INIS)

    Bigi, Marco; Rinaldi, Luigi; Simon, Muriel; Sita, Luca; Taddia, Giuseppe; Carrozza, Saverino; Decamps, Hans; Luchetta, Adriano; Meddour, Abdelraouf; Moressa, Modesto; Morri, Cristiano; Musile Tanzi, Antonio; Recchia, Mauro; Wagner, Uwe; Zamengo, Andrea; Toigo, Vanni

    2015-01-01

    Highlights: • 5 MVA ion source power supplies effectively integrated in 150 m"2 Faraday cage. • Load protection and performance requirements met of custom design high voltage power supplies. • 200 kW tetrode oscillator with 200 kHz frequency range successfully tested. - Abstract: The SPIDER experiment, currently under construction at the Neutral Beam Test Facility in Padua, Italy, is a full-size prototype of the ion source for the ITER Neutral Beam Injectors. The Ion Source and Extraction Power Supplies (ISEPS) for SPIDER are supplied by OCEM Energy Technology s.r.l. (OCEM) under a procurement contract with Fusion for Energy (F4E) covering also the units required for MITICA and ITER injectors. The detailed design of SPIDER ISEPS was finalized in 2011 and manufacture of most components completed by end 2013. The Factory Acceptance Tests took place early 2014. ISEPS, with an overall power rating of 5 MVA, form a heterogeneous set of items including solid state power converters and 1 MHz radiofrequency generators of 200 kW output power. The paper presents the main features of the detailed design developed by OCEM, focusing in particular on the high output voltage pulse step modulators, the high output current resonant converters, the radiofrequency generators by HIMMELWERK GmbH and the architecture and implementation of the complex control system. Details are given on non-standard factory tests verifying the insulation requirements specific to this application. Performance of ISEPS during the factory acceptance tests is described, with emphasis on demonstration of the load protection requirements, a crucial point for all neutral beam power supplies. Finally, key dates of SPIDER ISEPS installation and site testing schedule are provided.

  13. Design, manufacture and factory testing of the Ion Source and Extraction Power Supplies for the SPIDER experiment

    Energy Technology Data Exchange (ETDEWEB)

    Bigi, Marco, E-mail: marco.bigi@igi.cnr.it [Consorzio RFX (CNR, ENEA, INFN, Università di Padova, Acciaierie Venete SpA), Corso Stati Uniti 4, 35127 Padova (Italy); Rinaldi, Luigi [OCEM Energy Technology, Via della Solidarietà 2/1, 40056 Valsamoggia (località Crespellano), Bologna (Italy); Simon, Muriel [Fusion for Energy, Josep Pla 2, 08019 Barcelona (Spain); Sita, Luca; Taddia, Giuseppe; Carrozza, Saverino [OCEM Energy Technology, Via della Solidarietà 2/1, 40056 Valsamoggia (località Crespellano), Bologna (Italy); Decamps, Hans [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul lez Durance (France); Luchetta, Adriano [Consorzio RFX (CNR, ENEA, INFN, Università di Padova, Acciaierie Venete SpA), Corso Stati Uniti 4, 35127 Padova (Italy); Meddour, Abdelraouf [HIMMELWERK Hoch- und Mittelfrequenzanlagen GmbH, Jopestr. 10, 72072 Tübingen (Germany); Moressa, Modesto [Consorzio RFX (CNR, ENEA, INFN, Università di Padova, Acciaierie Venete SpA), Corso Stati Uniti 4, 35127 Padova (Italy); Morri, Cristiano; Musile Tanzi, Antonio [OCEM Energy Technology, Via della Solidarietà 2/1, 40056 Valsamoggia (località Crespellano), Bologna (Italy); Recchia, Mauro [Consorzio RFX (CNR, ENEA, INFN, Università di Padova, Acciaierie Venete SpA), Corso Stati Uniti 4, 35127 Padova (Italy); Wagner, Uwe [HIMMELWERK Hoch- und Mittelfrequenzanlagen GmbH, Jopestr. 10, 72072 Tübingen (Germany); Zamengo, Andrea; Toigo, Vanni [Consorzio RFX (CNR, ENEA, INFN, Università di Padova, Acciaierie Venete SpA), Corso Stati Uniti 4, 35127 Padova (Italy)

    2015-10-15

    Highlights: • 5 MVA ion source power supplies effectively integrated in 150 m{sup 2} Faraday cage. • Load protection and performance requirements met of custom design high voltage power supplies. • 200 kW tetrode oscillator with 200 kHz frequency range successfully tested. - Abstract: The SPIDER experiment, currently under construction at the Neutral Beam Test Facility in Padua, Italy, is a full-size prototype of the ion source for the ITER Neutral Beam Injectors. The Ion Source and Extraction Power Supplies (ISEPS) for SPIDER are supplied by OCEM Energy Technology s.r.l. (OCEM) under a procurement contract with Fusion for Energy (F4E) covering also the units required for MITICA and ITER injectors. The detailed design of SPIDER ISEPS was finalized in 2011 and manufacture of most components completed by end 2013. The Factory Acceptance Tests took place early 2014. ISEPS, with an overall power rating of 5 MVA, form a heterogeneous set of items including solid state power converters and 1 MHz radiofrequency generators of 200 kW output power. The paper presents the main features of the detailed design developed by OCEM, focusing in particular on the high output voltage pulse step modulators, the high output current resonant converters, the radiofrequency generators by HIMMELWERK GmbH and the architecture and implementation of the complex control system. Details are given on non-standard factory tests verifying the insulation requirements specific to this application. Performance of ISEPS during the factory acceptance tests is described, with emphasis on demonstration of the load protection requirements, a crucial point for all neutral beam power supplies. Finally, key dates of SPIDER ISEPS installation and site testing schedule are provided.

  14. Evaluation of the influence of base and alkyl bromide on synthesis of pyrazinoic acid esters through factorial design

    International Nuclear Information System (INIS)

    Fernandes, Joao Paulo dos Santos; Felli, Veni Maria Andres

    2009-01-01

    Pyrazinoic acid esters have been synthesized as prodrugs of pyrazinoic acid. In the literature, its preparation is reported through the reaction of pyrazinoyl chloride with alcohols and the reaction with DCC/DMAP. In this work, it is reported a 22 factorial design to evaluate the preparation of these esters through the substitution of alkyl bromides with carboxylate anion. The controlled factors were alkyl chain length of bromides (ethyl and hexyl) and the used base (triethylamine and DBU). Results revealed that the used base used has significant effect on yield, and alkyl bromide used has neither significant influence, nor its interaction effect with base. (author)

  15. Design of the cryogenic systems for the Near and Far LAr-TPC detectors of the Short-Baseline Neutrino program (SBN) at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Geynisman, M. [Fermilab; Bremer, J. [CERN; Chalifour, M. [CERN; Delaney, M. [Fermilab; Dinnon, M. [Fermilab; Doubnik, R. [Fermilab; Hentschel, S. [Fermilab; Kim, M. J. [Fermilab; Montanari, C. [INFN, Pavia; Monatanari, D. [Fermilab; Nichols, T. [Fermilab; Norris, B. [Fermilab; Sarychev, M. [Fermilab; Schwartz, F. [Fermilab; Tillman, J. [Fermilab; Zuckerbrot, M. [Fermilab

    2017-08-31

    The Short-Baseline Neutrino (SBN) physics program at Fermilab and Neutrino Platform (NP) at CERN are part of the international Neutrino Program leading to the development of Long-Baseline Neutrino Facility/Deep Underground Neutrino Experiment (LBNF/DUNE) science project. The SBN program consisting of three Liquid Argon Time Projection Chamber (LAr-TPC) detectors positioned along the Booster Neutrino Beam (BNB) at Fermilab includes an existing detector known as MicroBooNE (170-ton LAr-TPC) plus two new experiments known as SBN’s Near Detector (SBND, ~260 tons) and SBN’s Far Detector (SBN-FD, ~760 tons). All three detectors have distinctly different design of their cryostats thus defining specific requirements for the cryogenic systems. Fermilab has already built two new facilities to house SBND and SBN-FD detectors. The cryogenic systems for these detectors are in various stages of design and construction with CERN and Fermilab being responsible for delivery of specific sub-systems. This contribution presents specific design requirements and typical implementation solutions for each sub-system of the SBND and SBN-FD cryogenic systems.

  16. Test results of distributed ion pump designs for the PEP-II Asymmetric B-Factory collider

    Energy Technology Data Exchange (ETDEWEB)

    Calderon, M.; Holdener, F.; Peterson, D. [Lawrence Livermore National Lab., CA (United States)] [and others

    1994-07-01

    The testing facility measurement methods and results of prototype distributed ion pump (DIP) designs for the PEP-II B-Factory High Energy Ring are presented. Two basic designs with 5- or 7-anode plates were tested at LLNL with penning cell sizes of 15, 18, and 21 mm. Direct comparison of 5- and 7-plate anodes with 18 mm holes shows increased pumping speed with the 7-plate design. The 5-plate, 18 mm and 7-plate, 15 mm designs both gave an average pumping speed of 135 1/s/m at 1 {times} 10{sup {minus}8} Torr nitrogen base pressure in a varying 0.18 T peak B-field. Comparison of the three hole sizes indicates that cells smaller than the 15 mm tested can be efficiently used to obtain higher pumping speeds for the same anode plate sizes used.

  17. Test results of distributed ion pump designs for the PEP-II Asymmetric B-Factory collider

    International Nuclear Information System (INIS)

    Calderon, M.; Holdener, F.; Peterson, D.

    1994-07-01

    The testing facility measurement methods and results of prototype distributed ion pump (DIP) designs for the PEP-II B-Factory High Energy Ring are presented. Two basic designs with 5- or 7-anode plates were tested at LLNL with penning cell sizes of 15, 18, and 21 mm. Direct comparison of 5- and 7-plate anodes with 18 mm holes shows increased pumping speed with the 7-plate design. The 5-plate, 18 mm and 7-plate, 15 mm designs both gave an average pumping speed of 135 1/s/m at 1 x 10 -8 Torr nitrogen base pressure in a varying 0.18 T peak B-field. Comparison of the three hole sizes indicates that cells smaller than the 15 mm tested can be efficiently used to obtain higher pumping speeds for the same anode plate sizes used

  18. Sudbury neutrino observatory

    International Nuclear Information System (INIS)

    Ewan, G.T.; Mak, H.B.; Robertson, B.C.

    1985-07-01

    This report discusses the proposal to construct a unique neutrino observatory. The observatory would contain a Cerenkov detector which would be located 2070 m below the earth's surface in an INCO mine at Creighton near Sudbury and would contain 1000 tons of D20 which is an excellent target material. Neutrinos carry detailed information in their spectra on the reactions taking place deep in the interstellar interior and also provide information on supernova explosions. In addition to their role as astrophysical probes a knowledge of the properties of neutrinos is crucial to theories of grand unification. There are three main objectives of the laboratory. The prime objective will be to study B electron neutrinos from the sun by a direct counting method that will measure their energy and direction. The second major objective will be to establish if electron neutrinos change into other neutrino species in transit from the sun to the earth. Finally it is hoped to be able to observe a supernova with the proposed detector. The features of the Sudbury Neutrino Observatory which make it unique are its high sensitivity to electron neutrinos and its ability to detect all other types of neutrinos of energy greater than 2.2 MeV. In section II of this proposal the major physics objectives are discussed in greater detail. A conceptual design for the detector, and measurements and calculations which establish the feasibility of the neutrino experiments are presented in section III. Section IV is comprised of a discussion on the possible location of the laboratory and Section V contains a brief indication of the main areas to be studied in Phase II of the design study

  19. Neutrino Physics

    CERN Document Server

    Barenboim, G.

    2014-12-10

    The Standard Model has been incredibly successful in predicting the outcome of almost all the experiments done up so far. In it, neutrinos are mass-less. However, in recent years we have accumulated evidence pointing to tiny masses for the neutrinos (as compared to the charged leptons). These masses allow neutrinos to change their flavour and oscillate. In these lectures I review the properties of neutrinos in and beyond the Standard Model.

  20. Design of the cryogenic systems for the Near and Far LAr-TPC detectors of the Short-Baseline Neutrino program (SBN) at Fermilab

    CERN Document Server

    Geynisman, M; Chalifour, M; Delaney, M; Dinnon, M; Doubnik, R; Hentschel, S; Kim, M J; Montanari, C; Montanari, D; Nichols, T; Norris, B; Sarychev, M; Schwartz, F; Tillman, J; Zuckerbrot, M

    2017-01-01

    The Short-Baseline Neutrino (SBN) physics program at Fermilab and Neutrino Platform (NP) at CERN are part of the international Neutrino Program leading to the development of Long-Baseline Neutrino Facility/Deep Underground Neutrino Experiment (LBNF/DUNE) science project. The SBN program consisting of three Liquid Argon Time Projection Chamber (LAr-TPC) detectors positioned along the Booster Neutrino Beam (BNB) at Fermilab includes an existing detector known as MicroBooNE (170-ton LAr-TPC) plus two new experiments known as SBN’s Near Detector (SBND, ~260 tons) and SBN’s Far Detector (SBN-FD, ~760 tons). All three detectors have distinctly different design of their cryostats thus defining specific requirements for the cryogenic systems. Fermilab has already built two new facilities to house SBND and SBN-FD detectors. The cryogenic systems for these detectors are in various stages of design and construction with CERN and Fermilab being responsible for delivery of specific sub-systems. This contribution prese...

  1. Advances and prospects of Bacillus subtilis cellular factories: From rational design to industrial applications.

    Science.gov (United States)

    Gu, Yang; Xu, Xianhao; Wu, Yaokang; Niu, Tengfei; Liu, Yanfeng; Li, Jianghua; Du, Guocheng; Liu, Long

    2018-05-15

    Bacillus subtilis is the most characterized gram-positive bacterium that has significant attributes, such as growing well on cheap carbon sources, possessing clear inherited backgrounds, having mature genetic manipulation methods, and exhibiting robustness in large-scale fermentations. Till date, B. subtilis has been identified as attractive hosts for the production of recombinant proteins and chemicals. By applying various systems and synthetic biology tools, the productivity features of B. subtilis can be thoroughly analyzed and further optimized via metabolic engineering. In the present review, we discussed why B. subtilis is the primary organisms used for metabolic engineering and industrial applications. Additionally, we summarized the recent advances in systems and synthetic biology, engineering strategies for improving cellular performances, and metabolic engineering applications of B. subtilis. In particular, we proposed emerging opportunities and essential strategies to enable the successful development of B. subtilis as microbial cell factories. Copyright © 2018. Published by Elsevier Inc.

  2. Newly designed double surface bimorph mirror for BL-15A of the photon factory

    Energy Technology Data Exchange (ETDEWEB)

    Igarashi, Noriyuki, E-mail: noriyuki.igarashi@kek.jp; Nitani, Hiroaki; Takeichi, Yasuo; Niwa, Yasuhiro; Abe, Hitoshi; Kimura, Masao; Mori, Takeharu; Nagatani, Yasuko; Kosuge, Takashi; Kamijo, Ai; Koyama, Atsushi; Shimizu, Nobutaka [Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan); Ohta, Hiromasa [Mitsubishi Electric System & Service Co., Ltd. 20F Carrot Tower 4-1-1 Taishido, Setagaya-ku, Tokyo 154-8520 (Japan)

    2016-07-27

    BL-15A is a new x-ray undulator beamline at the Photon Factory. It will be dedicated to two independent research activities, simultaneous XAFS/XRF/XRD experiments, and SAXS/WAXS/GI-SAXS studies. In order to supply a choice of micro-focus, low-divergence and collimated beams, a double surface bimorph mirror was recently developed. To achieve further mirror surface optimization, the pencil beam scanning method was applied for “in-situ” beam inspection and the Inverse Matrix method was used for determination of optimal voltages on the piezoelectric actuators. The corrected beam profiles at every focal spot gave good agreement with the theoretical values and the resultant beam performance is promising for both techniques. Quick and stable switching between highly focused and intense collimated beams was established using this new mirror with the simple motorized stages.

  3. Study on light and thermal energy of illumination device for plant factory design

    Science.gov (United States)

    Yoshida, A.; Moriuchi, K.; Ueda, Y.; Kinoshita, S.

    2018-01-01

    To investigate the effect of illumination devices on the yield of crops cultivated in a plant factory, it is necessary to measure the actual cultivation environmental factors related to the plant growth and understand the distribution ratio of light and thermal energy to the electrical energy injected into the illumination device. Based on cultivation results, we found that light intensity greatly affected the growth of plant weight. Regarding the selection of illumination device, its spectral components also affected the morphological change. Lighting experiments using a high frequency (Hf) fluorescent lamp and a light emitting diode (LED) bulb were performed. A certain difference was found in the distribution ratio of light energy to electrical energy between Hf and LED. It was showed that by placing the safety equipment or internal circuits outside the cultivated site, the air conditioning load could be reduced.

  4. The application of MVC design pattern in Daya bay reactor neutrino experiments online safety training system

    International Nuclear Information System (INIS)

    Liu Guanchuan; Chu Yuanping

    2011-01-01

    The article made an introduction to MVC, which is an architectural pattern used in software engineering. It specified the advantages and disadvantages of MVC and also the application of MVC in Daya Bay nuclear reactor neutrino experiment online safety training system. (authors)

  5. Los Neutrinos Los Neutrinos

    Directory of Open Access Journals (Sweden)

    Julián Félix

    2012-02-01

    Full Text Available From all the proposals to understand the structure of matter, and the way the natural world is conformed, the one about neutrinos is the most enigmatic, abstract, and foreign to immediate experience; however, this is the one that has delved more deeply over the nearly eighty years since it was formulated by Wolfgang Pauli –in 1930- as a radical proposition to understand nucleon decay, and the decay of other particles, without the violation of the principle of conservation of energy and momentum at subatomic level. This proposition has evolved through the years, and from Pauli’s original idea only the basic elements remain.This article contains the tale of the hypothesis of neutrinos, its early history, its evolution up to present day, and the efforts done nowadays to study them. In summary, this is the physics of neutrinos. De todas las propuestas para entender la estructura de la materia, y la conformación del mundo natural, los neutrinos es la más enigmática, abstracta, y ajena a la experiencia inmediata; sin embargo, es la que más hondo ha ido calando a lo largo de los ya casi ochenta años de haber sido formulada por Wolfgang Pauli –en el año 1930- como una medida radical para entender el decaimiento de los nucleones, y otras partículas, sin que se violara el principio de la conservación de la energía y del momento a nivel subatómico. La propuesta ha evolucionado a lo largo de los años, y de la idea original de Pauli ya sólo lo básico permanece. En este artículo está el relato de la hipótesis de los neutrinos, su historia primera, su evolución hasta el presente, los esfuerzos que en la actualidad se realizan para estudiarlos. En breve, ésta es la física de los neutrinos.

  6. Analyzing the shape parameter effects on the performance of the mixed-flow fan using CFD and Factorial design

    International Nuclear Information System (INIS)

    Jung, Uk Hee; Kim, Joon Hyung; Kim, Sung; Kim, Jin Hyuk; Choi, Young Seok

    2016-01-01

    Fans are representative turbo-machinery widely used for ventilation throughout the industrial world. Recently, as the importance of energy saving has been magnified with the fans, the demand for the fans with high efficiency and performance has been increasing. The representative method for enhancing the performance includes design optimization; in practice, fan performance can be improved by changing the shape parameters such as those of meridional plane, impeller, and diffuser. Before optimizing the efficient design, a process of screening to select important design parameters is essential. The present study aimed to analyze the effects of mixed-flow fans' shape parameters on fan performance (static pressure and fan static efficiency) and derive optimum models based on the results. In this study, the shape parameters considered in the impeller domain are as follows: tip clearance, number of blades, beta angle of Leading edge (LE) in the blade, and beta angle of Trailing edge (TE) in the blade. The shape parameters considered in the diffuser domain are as follows: meridional length of the Guide vane (GV), number of GV, beta angle of LE in the GV and beta angle of TE in the GV. The effects of individual shape parameters were analyzed using the CFD (Computational fluid dynamic) and DOE (Design of experiments) methods. The reliability of CFD was verified through the comparison between preliminary fan model's experiment results and CFD results, and screening processes were implemented through 24-1 fractional factorial design. From the analysis of DOE results, it could be seen that the tip clearance and the number of blades in the impeller domain greatly affected the fan performance, and the beta angle of TE at the GV in the diffuser domain greatly affected the fan performance. Finally, the optimum models with improved fan performance were created using linear regression equations derived from 24-1 fractional factorial design.

  7. Formulation, evaluation and 3(2) full factorial design-based optimization of ondansetron hydrochloride incorporated taste masked microspheres.

    Science.gov (United States)

    Kharb, Vandana; Saharan, Vikas Anand; Dev, Kapil; Jadhav, Hemant; Purohit, Suresh

    2014-11-01

    Masking the bitter taste of Ondansetron hydrochloride (ONS) may improve palatability, acceptance and compliance of ONS products. ONS-loaded, taste-masked microspheres were prepared with a polycationic pH-sensitive polymer and 3(2) full factorial design (FFD) was applied to optimize microsphere batches. Solvent evaporation, in acetone--methanol/liquid paraffin system, was used to prepare taste-masked ONS microspheres. The effect of varying drug/polymer (D/P) ratios on microspheres characteristics were studied by 3(2) FFD. Desirability function was used to search the optimum formulation. Microspheres were evaluated by FTIR, XRD and DSC to examine interaction and effect of microencapsulation process. In vitro taste assessment approach based on bitterness threshold and drug release was used to assess bitterness scores. Prepared ONS microspheres were spherical and surface was wrinkled. ONS was molecularly dispersed in microspheres without any incompatibility with EE100. In hydrochloric acid buffer pH 1.2, ONS released completely from microsphere in just 10 min. Contrary to this, ONS release at initial 5 min from taste-masked microspheres was less than the bitterness threshold. Full factorial design and in vitro taste assessment approach, coupled together, was successfully applied to develop and optimize batches of ONS incorporated taste-masked microspheres.

  8. Application of full 42 Factorial Design for the Development and Characterization of Insecticidal Soap from Neem Oil

    Directory of Open Access Journals (Sweden)

    A. S. KOVO

    2006-01-01

    Full Text Available The aim of this paper was to investigate the extraction, characterization and production of insecticidal soap from Neem oil using full 42 factorial design. Soxhlet extractor was used for the extraction purpose and two solvent was chosen to determine which is better. N-hexane gives a Neem oil yield of 45.43% while ethanol gives a yield of 46.38%, confirming the earlier literature result giving ethanol as better solvent for Neem oil extraction. The basic properties of the oil were determined as follows, saponification value 215.95ml/g, acid value 1.122g/mol, unsaponifiable matter 19.66 etc. The Neem oil was found to have a colour of golden yellow due to the presence of Nimbidin.Full 42 factorial design and mathematical model was applied to the extraction process and a first order regression equation of the form:Y = 9.548 + 0.144X1 + 0.1931X2 + 0.1892 X12was obtained growing the individual effect of time and solvent type as parameter and their interaction in the entire extraction process the Neem insecticidal soap was found to be effective in insect and pest control.

  9. Optimization of thiamethoxam adsorption parameters using multi-walled carbon nanotubes by means of fractional factorial design.

    Science.gov (United States)

    Panić, Sanja; Rakić, Dušan; Guzsvány, Valéria; Kiss, Erne; Boskovic, Goran; Kónya, Zoltán; Kukovecz, Ákos

    2015-12-01

    The aim of this work was to evaluate significant factors affecting the thiamethoxam adsorption efficiency using oxidized multi-walled carbon nanotubes (MWCNTs) as adsorbents. Five factors (initial solution concentration of thiamethoxam in water, temperature, solution pH, MWCNTs weight and contact time) were investigated using 2V(5-1) fractional factorial design. The obtained linear model was statistically tested using analysis of variance (ANOVA) and the analysis of residuals was used to investigate the model validity. It was observed that the factors and their second-order interactions affecting the thiamethoxam removal can be divided into three groups: very important, moderately important and insignificant ones. The initial solution concentration was found to be the most influencing parameter on thiamethoxam adsorption from water. Optimization of the factors levels was carried out by minimizing those parameters which are usually critical in real life: the temperature (energy), contact time (money) and weight of MWCNTs (potential health hazard), in order to maximize the adsorbed amount of the pollutant. The results of maximal adsorbed thiamethoxam amount in both real and optimized experiments indicate that among minimized parameters the adsorption time is one that makes the largest difference. The results of this study indicate that fractional factorial design is very useful tool for screening the higher number of parameters and reducing the number of adsorption experiments. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. A systematic approach to designing statistically powerful heteroscedastic 2 × 2 factorial studies while minimizing financial costs

    Directory of Open Access Journals (Sweden)

    Show-Li Jan

    2016-08-01

    Full Text Available Abstract Background The 2 × 2 factorial design is widely used for assessing the existence of interaction and the extent of generalizability of two factors where each factor had only two levels. Accordingly, research problems associated with the main effects and interaction effects can be analyzed with the selected linear contrasts. Methods To correct for the potential heterogeneity of variance structure, the Welch-Satterthwaite test is commonly used as an alternative to the t test for detecting the substantive significance of a linear combination of mean effects. This study concerns the optimal allocation of group sizes for the Welch-Satterthwaite test in order to minimize the total cost while maintaining adequate power. The existing method suggests that the optimal ratio of sample sizes is proportional to the ratio of the population standard deviations divided by the square root of the ratio of the unit sampling costs. Instead, a systematic approach using optimization technique and screening search is presented to find the optimal solution. Results Numerical assessments revealed that the current allocation scheme generally does not give the optimal solution. Alternatively, the suggested approaches to power and sample size calculations give accurate and superior results under various treatment and cost configurations. Conclusions The proposed approach improves upon the current method in both its methodological soundness and overall performance. Supplementary algorithms are also developed to aid the usefulness and implementation of the recommended technique in planning 2 × 2 factorial designs.

  11. The KAON Factory at TRIUMF

    International Nuclear Information System (INIS)

    Craddock, M.K.

    1992-08-01

    The TRIUMF KAON Factory is designed to produce beams of kaons, antiprotons, other hadrons and neutrinos 100 times more intense, or cleaner, than are available now, for a broad range of particle and nuclear physics experiments. This will require a 100 μA beam of 30 GeV protons, to be produced by an interleaved sequence of two fast-cycling synchrotrons and three storage rings, with the existing TRIUMF H - cyclotron as injector. An $11-million preconstruction study has enabled the overall design to be reviewed and prototypes of various components to be built and evaluated -fast-cycling dipole and quadrupole magnets, a dual-frequency magnet power supply, ceramic beam pipes with internal rf shields, and rf cavity (using perpendicular bias), an extraction kicker, and rf beam chopper, and production targets. Environmental, industrial and economic impact studies have also been completed and the cost estimates and schedule updated. The total cost of $708 million (Canadian) will be shared equally between Canada, British Columbia and international contributors: the first two-thirds of this sum have already been approved and negotiations for the remainder are under way. 25 refs., 7 figs

  12. The KAON factory at TRIUMF

    International Nuclear Information System (INIS)

    Craddock, M.K.

    1992-07-01

    The TRIUMF KAON Factory is designed to produce beams of kaons, antiprotons, other hadrons and neutrinos 100 times more intense, or cleaner, than are available now, for a broad range of particle and nuclear physics experiments. This will require a 100 μA beam of 30 GeV protons, to be produced by an interleaved sequence of two fast-cycling synchrotrons and three storage rings, with the existing TRIUMF H - cyclotron as injector. An $11-million pre-construction study has enabled the overall design to be reviewed and prototypes of various components to be built and evaluated: fast-cycling dipole and quadrupole magnets, a dual frequency magnet power supply, ceramic beam pipes with internal rf shields, an rf cavity (using perpendicular bias), an extraction kicker, an rf beam chopper, and production targets. Environmental, industrial and economic impact studies have also been completed and the cost estimates and schedule updated. The total cost of $708 million (Canadian) will be shared equally between Canada, British Columbia and international contributors; the first two-thirds of this sum have already been approved and negotiations for the remainder are under way. 26 refs., 6 figs

  13. Solar neutrinos

    International Nuclear Information System (INIS)

    Phillips, R.J.N.

    1987-09-01

    The problem with solar neutrinos is that there seem to be too few of them, at least near the top end of the spectrum, since the 37 Cl detector finds only about 35% of the standard predicted flux. Various kinds of explanation have been offered: (a) the standard solar model is wrong, (b) neutrinos decay, (c) neutrinos have magnetic moments, (d) neutrinos oscillate. The paper surveys developments in each of these areas, especially the possible enhancement of neutrino oscillations by matter effects and adiabatic level crossing. The prospects for further independent experiments are also discussed. (author)

  14. Sterile neutrino

    International Nuclear Information System (INIS)

    Anon.

    2007-01-01

    Paper deals with the information on the occurrence of the fields of the sterile neutrinos (the righthanded ones) mixed with the normal neutrinos (the lefthanded ones). Both the Max Plank Radioastronomy Institute and the Los Angeles University assumes that the occurrence of the keV mass sterile neutrinos may explain the dark matter nature, the fast rotation of the observed pulsars and the reionization processes. The issues associated with the possibility to record the sterile neutrinos were analyzed in the course of the Sterile Neutrinos in Astrophysics and Cosmology Workshop (Crans Montana, March 2006 [ru

  15. Sterile Neutrino Search with MINOS

    International Nuclear Information System (INIS)

    Devan, Alena V.

    2015-01-01

    MINOS, Main Injector Neutrino Oscillation Search, is a long-baseline neutrino oscillation experiment in the NuMI muon neutrino beam at the Fermi National Accelerator Laboratory in Batavia, IL. It consists of two detectors, a near detector positioned 1 km from the source of the beam and a far detector 734 km away in Minnesota. MINOS is primarily designed to observe muon neutrino disappearance resulting from three flavor oscillations. The Standard Model of Particle Physics predicts that neutrinos oscillate between three active flavors as they propagate through space. This means that a muon-type neutrino has a certain probability to later interact as a different type of neutrino. In the standard picture, the neutrino oscillation probabilities depend only on three neutrino flavors and two mass splittings, Δm 2 . An anomaly was observed by the LSND and MiniBooNE experiments that suggests the existence of a fourth, sterile neutrino flavor that does not interact through any of the known Standard Model interactions. Oscillations into a theoretical sterile flavor may be observed by a deficit in neutral current interactions in the MINOS detectors. A distortion in the charged current energy spectrum might also be visible if oscillations into the sterile flavor are driven by a large mass-squared difference, Δm s 2 ~ 1 eV 2 . The results of the 2013 sterile neutrino search are presented here.

  16. Sterile Neutrino Search with MINOS

    Energy Technology Data Exchange (ETDEWEB)

    Devan, Alena V. [College of William and Mary, Williamsburg, VA (United States)

    2015-08-01

    MINOS, Main Injector Neutrino Oscillation Search, is a long-baseline neutrino oscillation experiment in the NuMI muon neutrino beam at the Fermi National Accelerator Laboratory in Batavia, IL. It consists of two detectors, a near detector positioned 1 km from the source of the beam and a far detector 734 km away in Minnesota. MINOS is primarily designed to observe muon neutrino disappearance resulting from three flavor oscillations. The Standard Model of Particle Physics predicts that neutrinos oscillate between three active flavors as they propagate through space. This means that a muon-type neutrino has a certain probability to later interact as a different type of neutrino. In the standard picture, the neutrino oscillation probabilities depend only on three neutrino flavors and two mass splittings, Δm2. An anomaly was observed by the LSND and MiniBooNE experiments that suggests the existence of a fourth, sterile neutrino flavor that does not interact through any of the known Standard Model interactions. Oscillations into a theoretical sterile flavor may be observed by a deficit in neutral current interactions in the MINOS detectors. A distortion in the charged current energy spectrum might also be visible if oscillations into the sterile flavor are driven by a large mass-squared difference, ms2 ~ 1 eV2. The results of the 2013 sterile neutrino search are presented here.

  17. Neutrinos today

    International Nuclear Information System (INIS)

    Pontecorvo, B.; Bilen'kij, S.

    1987-01-01

    After the famous 1983 discovery of intermediate W, Z 0 bosons it may be stated with certainty that W, Z 0 are entirely responsible for the production of neutrinos and for their interactions. Neutrino physics notions are presented from this point of view in the first four introductory, quite elementary, paragraphs of the paper. The following seven paragraphs are more sophisticated. They are devoted to the neutrino mass and neutrino mixing question, which is the most actual problem in today neutrino physics. Vacuum neutrino oscillations, matter neutrino oscillations and netrinoless double-decay are considered. Solar neutrino physics is discussed in some detail from the point of view of vacuum and matter neutrino oscillations. The role played by neutrinos in the Universe is briefly considered. In the last paragraph there discussed the probable observation by different groups of neutrinos connected with the Supernova 1987 A: the first observation of gravitational star collapse (at least the general rehearsal of such observation) opens up a new era in astronomy of today exerimental physics and astrophysics is presented at the end of the paper in the form of a Table

  18. Preliminary conceptual design for a 510 MeV electron/positron injector for a UCLA φ factory

    International Nuclear Information System (INIS)

    Dahlbacka, G.; Hartline, R.; Barletta, W.; Pellegrini, C.

    1991-01-01

    UCLA is proposing a compact suer conducting high luminosity (10 32-33 cm -2 sec -1 ) e + e - collider for a φ factory. To achieve the required e + e - currents, full energy injections from a linac with intermediate storage in a Positron Accumulator Ring (PAR) is used. The elements of the linac are outlined with cost and future flexibility in mind. The preliminary conceptual design starts with a high current gun similar in design to those developed at SLAC and at ANL (for the APS). Four 4-section linac modules follow, each driven by a 60 MW klystron with a 1 μsec macropulse and an average current of 8.6 A. The first 4-section model is used to create positrons in a tungsten target at 186 MeV. The three remaining three modules are used to accelerate the e + e - beam to 558 MeV (no load limit) for injection into the PAR

  19. Design and analysis of a wiggler magnet system for the PEP-II B-Factory LER

    International Nuclear Information System (INIS)

    Heim, J.; Kendall, M.; Bertolini, L.; Fackler, O.; O'Connor, T.; Swan, T.; Zholents, A.

    1996-01-01

    The Low Energy Ring (LER) of the PEP-II B-Factory will use a wiggler magnet system for emittance control and additional damping. The wiggler magnet system is a set of 11 individual iron core, water cooled, dipole magnets designed to operate at 1.6 T and generate 400 kW of synchrotron radiation. Space has been provided to add a second wiggler with an additional 400 kW of synchrotron radiation if more damping is needed in the future. A copper vacuum chamber is used with continuous antechambers connected to both sides of the beam chamber via slots. Synchrotron radiation dump surfaces and distributed vacuum pumping are located in both antechambers. The authors describe the design and analysis of the wiggler magnets and the salient features of the vacuum chamber and dumps

  20. FEASIBILITY STUDY II OF A MUON BASED NEUTRINO SOURCE.

    Energy Technology Data Exchange (ETDEWEB)

    GALLARDO,J.C.; OZAKI,S.; PALMER,R.B.; ZISMAN,M.

    2001-06-30

    The concept of using a muon storage ring to provide a well characterized beam of muon and electron neutrinos (a Neutrino Factory) has been under study for a number of years now at various laboratories throughout the world. The physics program of a Neutrino Factoryis focused on the relatively unexplored neutrino sector. In conjunction with a detector located a suitable distance from the neutrino source, the facility would make valuable contributions to the study of neutrino masses and lepton mixing. A Neutrino Factory is expected to improve the measurement accuracy of sin{sup 2}(2{theta}{sub 23}) and {Delta}m{sup 2}{sub 32} and provide measurements of sin{sup 2}(2{theta}{sub 13}) and the sign of {Delta}m{sup 2}{sub 32}. It may also be able to measure CP violation in the lepton sector.

  1. The Injection System of the INFN-SuperB Factory Project: Preliminary Design

    Energy Technology Data Exchange (ETDEWEB)

    Boni, Roberto; /INFN, Rome; Guiducci, Susanna; /INFN, Rome; Preger, Miro; /INFN, Rome; Raimondi, Pantaleo; /INFN, Rome; Chance, Antoine; /Saclay; Dadoun, Olivier; /Orsay, LAL; Poirier, Freddy; /Orsay, LAL; Variola, Alessandro; /Orsay, LAL; Seeman, John; /SLAC

    2012-07-05

    The ultra high luminosity B-factory (SuperB) project of INFN requires a high performance and reliable injection system, providing electrons at 4 GeV and positrons at 7 GeV, to fulfil the very tight requirements of the collider. Due to the short beam lifetime, continuous injection of electron and positron bunches in both LER and HER rings is necessary to maintain an high average luminosity. Polarized electrons are required for experiments and must be delivered by the injection system, due to the beam lifetime shorter than the ring polarization build-up: they will be produced by means of a SLAC-SLC polarized gun. The emittance and the energy spread of the e{sup -}/e{sup +} beams are reduced in a 1 GeV Damping Ring (DR) before injection in the main rings. Two schemes for positron production are under study, one with e{sup -}/e{sup +} conversion at low energy (< 1 Gev) and one with conversion at 6 GeV and a recirculation line to bring the positrons back to the DR. Acceleration through the Linac is provided by a 2856 MHz RF system made of travelling wave (TW), room temperature accelerating structures.

  2. Internet Factories

    NARCIS (Netherlands)

    Strijkers, R.J.

    2014-01-01

    This thesis contributes a novel concept for introducing new network technologies in network infrastructures. The concept, called Internet factories, describes the methodical process to create and manage application-specific networks from application programs, referred to as Netapps. An Internet

  3. Internet factories

    NARCIS (Netherlands)

    Strijkers, R.J.

    2014-01-01

    This thesis contributes a novel concept for introducing new network technologies in network infrastructures. The concept, called Internet factories, describes the methodical process to create and manage application-specific networks from application programs, referred to as Netapps. An Internet

  4. Factory physics

    CERN Document Server

    Hopp, Wallace J.

    2011-01-01

    After a brief introductory chapter, "Factory Physics 3/e" is divided into three parts: I - The Lessons of History; II - Factory Physics; and III - Principles in Practice. The scientific approach to manufacturing and supply chain management, developed in Part II, is unique to this text. No other text or professional book provides a rigorous, principles-based foundation for manufacturing management. The Third Edition offers tighter connections between Lean Manufacturing, MRP/ERP, Six Sigma, Supply Chain Management, and Factory Physics. In addition to enhancing the historical overview of how these systems evolved, the authors show explicitly how users can achieve Lean Manufacturing objectives (faster response, less inventory) using the integration aspects of MRP/ERP/SCM systems along with the variance analysis methods of Six Sigma. Factory Physics provides the overarching framework that coordinates all of these initiatives into a single-focused strategy.

  5. Baby Factory

    African Journals Online (AJOL)

    Prof

    2018-01-24

    Jan 24, 2018 ... mass media have the power to easily propagate ideas on social change ... issue of 'baby factory' is becoming everyday news affecting the right of ... according to recent mass media reports, teenage girls and young women are.

  6. A new design for the CERN-Fréjus neutrino Super Beam

    CERN Document Server

    Longhin, A

    2011-01-01

    We present an optimization of the hadron focusing system for a low-energy high-intensity conventional neutrino beam (Super-Beam) proposed on the basis of the HP-SPL at CERN with a beam power of 4 MW and an energy of 4.5 GeV. The far detector would be a 440 kton Water Cherenkov detector (MEMPHYS) located at a baseline of 130 km in the Fr\\'ejus site. The neutrino fluxes simulation relies on a new GEANT4 based simulation coupled with an optimization algorithm based on the maximization of the sensitivity limit on the $\\theta_{13}$ mixing angle. A new configuration adopting a multiple horn system with solid targets is proposed which improves the sensitivity to $\\theta_{13}$ and the CP violating phase $\\delta_{CP}$.

  7. Neutrino sunshine

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    Full text: On 10 June 1992, at the Neutrino 92 meeting in Grenada, Spain, Till Kirsten of Heidelberg's Max Planck Institute reported that neutrinos from sunshine had been seen. Most of the energy pumped out by the Sun comes from the fusion of protons into alpha particles, a process which also liberates neutrinos. While it takes about a million years for radiant energy formed in the deep interior of the Sun to fight its way to the surface, the highly penetrating neutrinos emerge almost immediately. It was in 1970 that Ray Davis and his team began taking data with a tank containing 615 tons of perchloroethylene (dry cleaning fluid) 1500 metres underground in the Homestake gold mine, South Dakota. The observed signal is consistently smaller than what is expected. This 'solar neutrino problem' was confirmed by the Kamioka mine experiment in Japan, looking at the Cherenkov light released by neutrino interactions in some 700 tons of water. However these experiments are only sensitive to a tiny high energy tail of the solar neutrino spectrum, and to understand what is going on needs measurements of the primary neutrinos from proton fusion. To get at these neutrinos, two large new detectors, using gallium and sensitive to these lower energy particles, have been built and commissioned in the past few years. The detectors are SAGE ('Soviet' American Gallium Experiment) in the Baksan Neutrino Observatory in the Caucasus, and Gallex, a team from France, Germany, Israel, Italy and the US in the Italian Gran Sasso underground Laboratory. At Grenada, Kirsten reported unmistakable signs of solar neutrinos of proton origin recorded in Gallex. SAGE and Gallex do not yet have enough data to unambiguously fix the level of primary solar neutrinos reaching the Earth, and the interpretation of the interim results tends to be subjective. However after 23 years of conditioning through watching the solar neutrinos' high energy tail, the prospect of a neutrino

  8. A Factorial Design Approach to Analyse the Effect of Coarse Recycled Concrete Aggregates on the Properties of Hot Mix Asphalt

    Science.gov (United States)

    Tanty, Kiranbala; Mukharjee, Bibhuti Bhusan; Das, Sudhanshu Shekhar

    2018-06-01

    The present study investigates the effect of replacement of coarse fraction of natural aggregates by recycled concrete aggregates on the properties of hot mix asphalt (HMA) using general factorial design approach. For this two factors i.e. recycled coarse aggregates percentage [RCA (%)] and bitumen content percentage [BC (%)] are considered. Tests have been carried out on the HMA type bituminous concrete, prepared with varying RCA (%) and BC (%). Analysis of variance has been performed on the experimental data to determine the effect of the chosen factors on various parameters such as stability, flow, air void, void mineral aggregate, void filled with bitumen and bulk density. The study depicts that RCA (%) and BC (%) have significant effect on the selected responses as p value is less than the chosen significance level. In addition to above, the outcomes of the statistical analysis indicate that interaction between factors have significant effects on void mineral aggregate and bulk density of bituminous concrete.

  9. Use of fractional factorial design for selection of nutrients for culturing Paecilomyces variotii in eucalyptus hemicellulosic hydrolysate

    Directory of Open Access Journals (Sweden)

    J.B. Almeida e Silva

    1998-09-01

    Full Text Available A eucalyptus hemicellulose fraction was hydrolysed by treating eucalyptus wood chips with sulfuric acid. The hydrolysate was used as the substrate to grow Paecilomyces variotii IOC-3764 cultured for 72 or 96 hours. The influence of the inhibitors, nutrients and fermentation time was verified by a 28-4 and, subsequently, a 25-1 fractional factorial design. The effects of the inhibitors (acetic acid and furfural, nutrients (rice bran, urea, potassium nitrate, ammonium sulfate, magnesium sulfate and sodium phosphate and fermentation time were investigated. The highest yield (10.59 g/L of biomass was obtained when the microorganisms were cultivated for 72 hours in a medium composed of 30 g/L rice bran, 9.4 g/L ammonium sulfate (2 g/L nitrogen and 2 g/L sodium phosphate.

  10. Optimization of Amylase and Protease Production from Aspergillus awamori in Single Bioreactor Through EVOP Factorial Design Technique

    Directory of Open Access Journals (Sweden)

    Sangeeta Negi

    2006-01-01

    Full Text Available Evolutionary operation (EVOP factorial design technique was explored in order to economically produce amylase and protease at their optimum level in a single bioreactor by modified solid-state fermentation. Maximum yields of amylase and protease were achieved, using wheat bran as a substrate by a highly potent, locally isolated strain of Aspergillus awamori: Nakazawa MTCC 6652. The strain had been induced previously, inferring the ability to produce both enzymes concomitantly in a single bioreactor with their maximum capacity. The highest secretion of amylase and protease were measured to be 9420.6 and 1930 U/g, respectively, at 37 °C. pH and relative humidity were found to be optimum at 4 and 85 %, evaluated through EVOP method.

  11. Evaluation of the use of steelmaking slag as an aggregate in concrete mix: A factorial design approach

    Directory of Open Access Journals (Sweden)

    Aljbour Salah H.

    2017-01-01

    Full Text Available Slag is investigated towards its potential use as an aggregate in concrete mix production. Full factorial design methodology is applied to study the effect of two process input variables, namely: slag as coarse aggregate and slag as medium aggregate on the properties of concrete mix. Additionally, the interaction between input variables is also examined. Incorporating steel slag aggregate in the concrete mix affected its compressive strength. Enhanced compressive strength concrete mix was obtained with 70 wt.% coarse slag aggregate and 70 wt.% medium slag aggregate. Under these proportions, the 28-days compressive strength was higher than the 28-days compressive strength of a concrete mix prepared from normal aggregate. Strong interaction effect exists between slag aggregate size on the compressive strength at 7-days curing. Lower compressive strength for the concrete mix might be obtained if improper proportions of mixed medium and coarse slag aggregate were employed.

  12. A Factorial Design Approach to Analyse the Effect of Coarse Recycled Concrete Aggregates on the Properties of Hot Mix Asphalt

    Science.gov (United States)

    Tanty, Kiranbala; Mukharjee, Bibhuti Bhusan; Das, Sudhanshu Shekhar

    2018-02-01

    The present study investigates the effect of replacement of coarse fraction of natural aggregates by recycled concrete aggregates on the properties of hot mix asphalt (HMA) using general factorial design approach. For this two factors i.e. recycled coarse aggregates percentage [RCA (%)] and bitumen content percentage [BC (%)] are considered. Tests have been carried out on the HMA type bituminous concrete, prepared with varying RCA (%) and BC (%). Analysis of variance has been performed on the experimental data to determine the effect of the chosen factors on various parameters such as stability, flow, air void, void mineral aggregate, void filled with bitumen and bulk density. The study depicts that RCA (%) and BC (%) have significant effect on the selected responses as p value is less than the chosen significance level. In addition to above, the outcomes of the statistical analysis indicate that interaction between factors have significant effects on void mineral aggregate and bulk density of bituminous concrete.

  13. Application of 2k Full Factorial Design in Optimization of Solvent-Free Microwave Extraction of Ginger Essential Oil

    Directory of Open Access Journals (Sweden)

    Mumtaj Shah

    2014-01-01

    Full Text Available The solvent-free microwave extraction of essential oil from ginger was optimized using a 23 full factorial design in terms of oil yield to determine the optimum extraction conditions. Sixteen experiments were carried out with three varying parameters, extraction time, microwave power, and type of sample for two levels of each. A first order regression equation best fits the experimental data. The predicted values calculated by the regression model were in good agreement with the experimental values. The results showed that the extraction time is the most prominent factor followed by microwave power level and sample type for extraction process. An average of 0.25% of ginger oil can be extracted using current setup. The optimum conditions for the ginger oil extraction using SFME were the extraction time 30 minutes, microwave power level 640 watts, and sample type, crushed sample. Solvent-free microwave extraction proves a green and promising technique for essential oil extraction.

  14. Calculation of stricken to mortality and incidence cancers due to beyond design basis accidents of the Esfahan Fuel Production Factory

    International Nuclear Information System (INIS)

    Heydari Azar, A.; Shahshahani, M.; Roshanzamir, M.; Sabouhi, R.

    2008-01-01

    In this investigation the amount of absorbed doses by the different pathways of Cloud shine, Ground shine, deposition of radioactive materials on skin and cloths, ingestion, inhalation and the consequences of radioactive material releases due to Beyond Design Basis Accidents such as fire, sintering furnace explosion, criticality and earthquake in Esfahan Fuel Production factory by the residents are evaluated. The calculations related to atomic cloud distribution, estimation of delivered dose and decay chains are performed by PCCOSYMA dose. These computations are based on radioactive source terms, distribution height of radioactive materials. actions for reducing the absorbed dose, human body physiological characteristics, metrological condition and population distribution. Finally, the number of peoples who are stricken to mortality and morbidity cancers and risk values are calculated for 1 year and 50 years

  15. Effect of a Preoperative Preparation Program on Anxiety in School-age Children Undergoing Surgery Using a Factorial Design

    Directory of Open Access Journals (Sweden)

    Maliheh Shoja

    2018-01-01

    Full Text Available Background: Surgery is a stressful experience in children. Therefore, the familiarization of this population with treatment processes by means of appropriate training tools and techniques can be an effective way to control their anxiety. Aim: The aim of this study was to determine the effect of a preoperative preparation program on anxiety in school-age children undergoing surgery using a factorial design. Method: This clinical trial was conducted on 81 children aged 6-12 years as candidates for elective surgery at Doctor Sheikh Hospital in Mashhad, Iran, in 2016. A preparation program was implemented with two methods (i.e., displaying video tutorials with and without nurses’ explanations and on two different days (i.e., prior to and on the day of operation using a factorial design. The estimation of children’s anxiety was accomplished by using the Revised Children’s Manifest Anxiety Scale administered before training and prior to operating room admission. The data were analyzed by statistical tests in SPSS software, version 16. Results: The study groups were comparable in terms of demographic characteristics (P>0.05. There was no significant differences among the four groups regarding manifest anxiety based on the place of referral (i.e., department or clinic (P=0.22, presentation or non-presentation of explanations by nurses (P=0.12, and their interaction effects (P=0.22. Implications for Practice: No significant difference was observed among the four groups in terms of manifest anxiety. Therefore, all four training methods were effective in reducing anxiety in children. Consequently, each of these methods can be used depending on human resources and infrastructure of each department.

  16. Neutrino Oscillation Experiment at JHF

    CERN Multimedia

    2002-01-01

    T2K is a long baseline neutrino experiment designed to investigate how neutrinos change from one flavor to another as they travel (neutrino oscillations). An intense beam of muon neutrinos is generated at the J-PARC nuclear physics site on the East coast of Japan and directed across the country to the Super-Kamiokande neutrino detector in the mountains of western Japan. The beam is measured once before it leaves the J-PARC site, using the near detector ND280, and again at Super-K, 295 km away: the change in the measured intensity and composition of the beam is used to provide information on the properties of neutrinos. The high intensity neutrino beam is produced in an off-axis configuration. The peak neutrino energy is tuned to the oscillation maximum of ∼ 0.6 GeV to maximize the sensitivity to neutrino oscillations. The science goals of T2K can be summarized as follows: •\tsearch for CP violation in the neutrino sector •\tdiscovery of νμ → νe ( i.e. the confirmation that θ13 > 0 ) •\tprecision ...

  17. NEUTRINO MASS

    OpenAIRE

    Kayser, Boris

    1988-01-01

    This is a review article about the most recent developments on the field of neutrino mass. The first part of the review introduces the idea of neutrino masses and mixing angles, summarizes the most recent experimental data then discusses the experimental prospects and challenges in this area. The second part of the review discusses the implications of these results for particle physics and cosmology, including the origin of neutrino mass, the see-saw mechanism and sequential dominance, and la...

  18. Neutrino masses

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    Postulated in the early days of quantum mechanics by Wolfgang Pauli to make energy-momentum conservation in nuclear beta decay come out right, the neutrino has never strayed far from physicists' attention. The Moriond Workshop on Massive Neutrinos in Particle Physics and Astrophysics held recently in the French Alps showed that more than half a century after Pauli's prediction, the neutrino stubbornly refuses to yield up all its secrets

  19. Neutrino masses

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1986-04-15

    Postulated in the early days of quantum mechanics by Wolfgang Pauli to make energy-momentum conservation in nuclear beta decay come out right, the neutrino has never strayed far from physicists' attention. The Moriond Workshop on Massive Neutrinos in Particle Physics and Astrophysics held recently in the French Alps showed that more than half a century after Pauli's prediction, the neutrino stubbornly refuses to yield up all its secrets.

  20. Neutrino mass

    International Nuclear Information System (INIS)

    Robertson, R.G.H.

    1992-01-01

    Despite intensive experimental work since the neutrino's existence was proposed by Pauli 60 years ago, and its first observation by Reines and Cowan almost 40 years ago, the neutrino's fundamental properties remain elusive. Among those properties are the masses of the three known flavors, properties under charge conjugation, parity and time-reversal, and static and dynamic electromagnetic moments. Mass is perhaps the most fundamental, as it constrains the other properties. The present status of the search for neutrino mass is briefly reviewed

  1. A review of metabolic and enzymatic engineering strategies for designing and optimizing performance of microbial cell factories

    Directory of Open Access Journals (Sweden)

    Amanda K. Fisher

    2014-08-01

    Full Text Available Microbial cell factories (MCFs are of considerable interest to convert low value renewable substrates to biofuels and high value chemicals. This review highlights the progress of computational models for the rational design of an MCF to produce a target bio-commodity. In particular, the rational design of an MCF involves: (i product selection, (ii de novo biosynthetic pathway identification (i.e., rational, heterologous, or artificial, (iii MCF chassis selection, (iv enzyme engineering of promiscuity to enable the formation of new products, and (v metabolic engineering to ensure optimal use of the pathway by the MCF host. Computational tools such as (i de novo biosynthetic pathway builders, (ii docking, (iii molecular dynamics (MD and steered MD (SMD, and (iv genome-scale metabolic flux modeling all play critical roles in the rational design of an MCF. Genome-scale metabolic flux models are of considerable use to the design process since they can reveal metabolic capabilities of MCF hosts. These can be used for host selection as well as optimizing precursors and cofactors of artificial de novo biosynthetic pathways. In addition, recent advances in genome-scale modeling have enabled the derivation of metabolic engineering strategies, which can be implemented using the genomic tools reviewed here as well.

  2. The PEP-II Asymmetric B Factory: Design details and R ampersand D results

    International Nuclear Information System (INIS)

    Bloom, E.; DeStaebler, H.; Dorfan, J.

    1994-06-01

    PEP-II, a 9 GeV x 3.1 GeV electron-positron collider with a design luminosity of 3 x 10 33 cm -2 s -1 has now been approved for construction by SLAC, LBL and LLNL for the purpose of studying CP violation in the B bar B system. This upgrade project involves replacing the vacuum and RF systeum of PEP, which will serve as the high-energy ring (HER), along with the addition of a new low-energy ring (LER) mounted atop the HER. Designs for both rings are described, and the anticipated project construction schedule is indicated. Collider operation will begin at the end of 1998. An aggressive R ampersand D program has been carried out to validate our design choices; key results in the areas of lattice design, vacuum, RF, and multibunch feedback are summarized

  3. Sub Tenth Micron CMOS Devices - A Demonstration of the Virtual Factory Approach to New Structure Design

    National Research Council Canada - National Science Library

    Plummer, James L

    1995-01-01

    ...'. This project is exploring the use of advanced TCAD simulation tools to design a candidate 21st century MOS device - a fully-depleted surrounding gate vertical MOSFET with self-aligned drain contact...

  4. Probing Neutrino Properties with Long-Baseline Neutrino Beams

    International Nuclear Information System (INIS)

    Marino, Alysia

    2015-01-01

    This final report on an Early Career Award grant began in April 15, 2010 and concluded on April 14, 2015. Alysia Marino's research is focussed on making precise measurements of neutrino properties using intense accelerator-generated neutrino beams. As a part of this grant, she is collaborating on the Tokai-to-Kamioka (T2K) long-baseline neutrino experiment, currently taking data in Japan, and on the Deep Underground Neutrino Experiment (DUNE) design effort for a future Long-Baseline Neutrino Facility (LBNF) in the US. She is also a member of the NA61/SHINE particle production experiment at CERN, but as that effort is supported by other funds, it will not be discussed further here. T2K was designed to search for the disappearance of muon neutrinos (?_?) and the appearance of electron neutrinos (?_e), using a beam of muon neutrino beam that travels 295 km across Japan towards the Super-Kamiokande detector. In 2011 T2K first reported indications of ?_e appearance, a previously unobserved mode of neutrino oscillations. In the past year, T2K has published a combined analysis of ?_? disappearance and ?_e appearance, and began collecting taking data with a beam of anti-neutrinos, instead of neutrinos, to search for hints of violation of the CP symmetry of the universe. The proposed DUNE experiment has similar physics goals to T2K, but will be much more sensitive due to its more massive detectors and new higher-intensity neutrino beam. This effort will be very high-priority particle physics project in the US over the next decade.

  5. Design of a factorial experiment with randomization restrictions to assess medical device performance on vascular tissue.

    Science.gov (United States)

    Diestelkamp, Wiebke S; Krane, Carissa M; Pinnell, Margaret F

    2011-05-20

    Energy-based surgical scalpels are designed to efficiently transect and seal blood vessels using thermal energy to promote protein denaturation and coagulation. Assessment and design improvement of ultrasonic scalpel performance relies on both in vivo and ex vivo testing. The objective of this work was to design and implement a robust, experimental test matrix with randomization restrictions and predictive statistical power, which allowed for identification of those experimental variables that may affect the quality of the seal obtained ex vivo. The design of the experiment included three factors: temperature (two levels); the type of solution used to perfuse the artery during transection (three types); and artery type (two types) resulting in a total of twelve possible treatment combinations. Burst pressures of porcine carotid and renal arteries sealed ex vivo were assigned as the response variable. The experimental test matrix was designed and carried out as a split-plot experiment in order to assess the contributions of several variables and their interactions while accounting for randomization restrictions present in the experimental setup. The statistical software package SAS was utilized and PROC MIXED was used to account for the randomization restrictions in the split-plot design. The combination of temperature, solution, and vessel type had a statistically significant impact on seal quality. The design and implementation of a split-plot experimental test-matrix provided a mechanism for addressing the existing technical randomization restrictions of ex vivo ultrasonic scalpel performance testing, while preserving the ability to examine the potential effects of independent factors or variables. This method for generating the experimental design and the statistical analyses of the resulting data are adaptable to a wide variety of experimental problems involving large-scale tissue-based studies of medical or experimental device efficacy and performance.

  6. Double success for neutrino lab

    CERN Multimedia

    2010-01-01

    "The Gran Sasso National Laboratory in Italy is celebrating two key developments in the field of neutrino physics. Number one is the first ever detection, by the OPERA experiement, of possible tau neutrino that has switched its identity from a muon neutrino as it travelled form its origins at CERN in Switzerland to the Italian lab. Number two is the successful start-up of the ICARUS detector, which, like OPERA, is designed to study neutrinos that "oscillate" between types" (0.5 pages)

  7. Eclipsed neutrinos

    International Nuclear Information System (INIS)

    Anon.

    1995-01-01

    Full text: The total solar eclipse visible in Southern Asia on 24 October provided an opportunity for an unusual physics experiment. At face value, the levels of solar neutrinos detected on the Earth's surface are difficult to understand and suggest that perhaps the composition of solar neutrinos oscillates between different neutrino types on their journey. In this way neutrinos originating in the Sun as electrontype could convert into heavy neutrinos, which could subsequently disintegrate into an electron-neutrino and a photon. In certain neutrino scenarios, such a photon would have an energy corresponding to that of visible light, and in principle should be detectable if there are enough of them. The problem is that they would normally be swamped by the copious photons of sunlight. The 24 October solar eclipse provided a chance to check this out. A team led by François Vannucci, spokesman of the Nomad neutrino experiment at CERN, en route to the 'Rencontres du Vietnam' physics meeting in Ho Chi Minh Ville, set up a CCD-equipped telescope. To insure against cloud cover, a second telescope followed the eclipse in the desert of Rajastan, India, where the eclipse was to last only half as long, but the chance of cloud was minimal. No background solar signal was seen, or, expressed in physics terms, if solar radiation has any heavy neutrino component, then less than a millionth of it disintegrates into an electron neutrino and a visible photon before it arrives at the Earth. The negative result also has implications for candidate massive, unstable neutrinos from other sources, notably a component of the missing 'dark matter' of the Universe. The next such eclipse should be visible in North Asia in 1997, when hopefully better measurements will be made

  8. A Randomized Longitudinal Factorial Design to Assess Malaria Vector Control and Disease Management Interventions in Rural Tanzania

    Directory of Open Access Journals (Sweden)

    Randall A. Kramer

    2014-05-01

    Full Text Available The optimization of malaria control strategies is complicated by constraints posed by local health systems, infrastructure, limited resources, and the complex interactions between infection, disease, and treatment. The purpose of this paper is to describe the protocol of a randomized factorial study designed to address this research gap. This project will evaluate two malaria control interventions in Mvomero District, Tanzania: (1 a disease management strategy involving early detection and treatment by community health workers using rapid diagnostic technology; and (2 vector control through community-supported larviciding. Six study villages were assigned to each of four groups (control, early detection and treatment, larviciding, and early detection and treatment plus larviciding. The primary endpoint of interest was change in malaria infection prevalence across the intervention groups measured during annual longitudinal cross-sectional surveys. Recurring entomological surveying, household surveying, and focus group discussions will provide additional valuable insights. At baseline, 962 households across all 24 villages participated in a household survey; 2,884 members from 720 of these households participated in subsequent malariometric surveying. The study design will allow us to estimate the effect sizes of different intervention mixtures. Careful documentation of our study protocol may also serve other researchers designing field-based intervention trials.

  9. A randomized longitudinal factorial design to assess malaria vector control and disease management interventions in rural Tanzania.

    Science.gov (United States)

    Kramer, Randall A; Mboera, Leonard E G; Senkoro, Kesheni; Lesser, Adriane; Shayo, Elizabeth H; Paul, Christopher J; Miranda, Marie Lynn

    2014-05-16

    The optimization of malaria control strategies is complicated by constraints posed by local health systems, infrastructure, limited resources, and the complex interactions between infection, disease, and treatment. The purpose of this paper is to describe the protocol of a randomized factorial study designed to address this research gap. This project will evaluate two malaria control interventions in Mvomero District, Tanzania: (1) a disease management strategy involving early detection and treatment by community health workers using rapid diagnostic technology; and (2) vector control through community-supported larviciding. Six study villages were assigned to each of four groups (control, early detection and treatment, larviciding, and early detection and treatment plus larviciding). The primary endpoint of interest was change in malaria infection prevalence across the intervention groups measured during annual longitudinal cross-sectional surveys. Recurring entomological surveying, household surveying, and focus group discussions will provide additional valuable insights. At baseline, 962 households across all 24 villages participated in a household survey; 2,884 members from 720 of these households participated in subsequent malariometric surveying. The study design will allow us to estimate the effect sizes of different intervention mixtures. Careful documentation of our study protocol may also serve other researchers designing field-based intervention trials.

  10. The participation of the Experimental Design Factory of the Uranium Industry of Czechoslovakia in the design of a tunneling machine with disk bits

    Energy Technology Data Exchange (ETDEWEB)

    Kastner, P

    1983-01-01

    A tunneling machine, two prototypes of which were designed and built jointly on the basis of scientific and technical cooperation between the Experimental Design Factory of the Uranium Industry of Czechoslovakia and the VEB-Schachtbau enterprise (East Germany), is described. The experimental design operations were conducted under the methodological leadership of the Mine Construction in the Uranium Industry (Czechoslovakia) enterprise. The experimental design factory developed a general design system for the machine and its individual subassemblies. The detailed technical documentation for the machine units was developed by both enterprises. Each enterprise made two complexes of specific units and spare parts. The prototypes were assembled in both countries with the technical assistance of the producer enterprise of the appropriate subassembly. Industrial tests were conducted by each enterprise independently with technical assistance and delivery of spare parts on the part of the producer enterprise. A machine under the title of VM 24-27 was used to drill more than 2,300 meters of water supply tunnel in East Germany in 1982 and a machine called the RS 24-27 (29) was used in Prague in the same year to drill approximately 1,400 meters of cable collectors. The machine is designed for the passage of rounded mine drifts with a diameter of 2.4 to 2.7 (2.9) meters) to the full cross section in stable rocks. Its overall length is 32.5 meters, while the total weight is 85 tons. The shift productivity was 9.55 meters. Since 1979 the Mining Construction in the Uranium Industry and the Experimental Design Plant of the Uranium Industry Enterprises of Czechoslovakia have supplied disk bits for the TVM Demag tunnel drilling machines (West Germany) and RS 24-27 and the HG 210 Wirth (West Germany) cross cut drills.

  11. Computational tools and lattice design for the PEP-II B-Factory

    International Nuclear Information System (INIS)

    Cai Yunhai; Irwin, John; Nosochkov, Yuri; Yan, Yiton

    1997-01-01

    Several accelerator codes were used to design the PEP-II lattices, ranging from matrix-based codes, such as MAD and DIMAD, to symplectic-integrator codes, such as TRACY and DESPOT. In addition to element-by-element tracking, we constructed maps to determine aberration strengths. Furthermore, we have developed a fast and reliable method (nPB tracking) to track particles with a one-turn map. This new technique allows us to evaluate performance of the lattices on the entire tune-plane. Recently, we designed and implemented an object-oriented code in C++ called LEGO which integrates and expands upon TRACY and DESPOT

  12. Puzzling out Neutrino Mixing Through Golden and Silver Measurements

    CERN Document Server

    Mena, O

    2003-01-01

    We update a recent work devoted to resolve the degeneracies that appear in the simultaneous extraction of $\\theta_{13}$ and $\\delta$ at future Neutrino Factories (NF, that exploit the \\emph{golden} channels, i.e. $\

  13. Phi factories

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    Plans for 'phi factories' gathered momentum with a recent workshop at UCLA. These machines, high luminosity electron-positron colliders working near the phi resonance at 1020 MeV, have been proposed at Laboratories in Europe, the US, Japan and the USSR

  14. PEP-II asymmetric B Factory: Design update and R ampersand D results

    International Nuclear Information System (INIS)

    Zisman, M.S.; Bell, R.A.; Dorfan, J.; Schwarz, H.; Barletta, W.A.; Calderon, M.

    1992-07-01

    PEP-II, a 9 GeV x 3.1 GeV e + e - collider with a design luminosity of 3 x 10 33 cm -2 s -1 , was proposed jointly by SLAC, LBL, and LLNL. Recent efforts have continued towards an optimized design. In addition, an aggressive R ampersand D program is under way to validate our design choices. Fabrication of a low-power prototype RF cavity is complete, and impedance measurements are beginning. A 500-kW, 476-MHz klystron has been completed; it will be used for testing both high-power RF windows and a prototype high-power cavity (now under design in collaboration with Chalk River Laboratory). Vacuum studies have demonstrated that chambers with suitable photodesorption properties can be fabricated. A mockup of the two-ring arc area has been completed and used to investigate alignment and stability issues. The PEP-II project is ready to begin construction as soon as funds become available

  15. Extrinsic CPT Violation in Neutrino Oscillations

    International Nuclear Information System (INIS)

    Ohlsson, Tommy

    2004-01-01

    In this talk, we investigate extrinsic CPT violation in neutrino oscillations in matter with three flavors. Note that extrinsic CPT violation is different from intrinsic CPT violation. Extrinsic CPT violation is one way of quantifying matter effects, whereas intrinsic CPT violation would mean that the CPT invariance theorem is not valid. We present analytical formulas for the extrinsic CPT probability differences and discuss their implications for long-baseline experiments and neutrino factory setups

  16. Neutrino Oscillations

    Indian Academy of Sciences (India)

    work of Takaaki Kajita and Arthur B McDonald clearly demon- strated the ... time belief that neutrinos are massless particles. .... SK is a second generation, 50,000 t wa- ..... values of the parameters of the PMNS matrix based on a global .... [13] Y Ashie et al., Evidence for an oscillatory signature in atmospheric neutrino.

  17. Characterization of large-area photomultipliers under low magnetic fields: Design and performance of the magnetic shielding for the Double Chooz neutrino experiment

    International Nuclear Information System (INIS)

    Calvo, E.; Cerrada, M.; Fernandez-Bedoya, C.; Gil-Botella, I.; Palomares, C.; Rodriguez, I.; Toral, F.; Verdugo, A.

    2010-01-01

    A precise quantitative measurement of the effect of low magnetic fields in Hamamatsu R7081 photomultipliers has been performed. These large-area photomultipliers will be used in the Double Chooz neutrino experiment. A magnetic shielding has been developed for these photomultipliers. Its design and performance is also reported in this paper.

  18. The Antarctic Impulsive Transient Antenna ultra-high energy neutrino detector: Design, performance, and sensitivity for 2006-2007 balloon flight

    Energy Technology Data Exchange (ETDEWEB)

    Gorham, P. W. [Univ. of Hawaii, Manoa, HI (United States); Allison, P. [Univ. of Hawaii, Manoa, HI (United States); Barwick, S. W. [Univ. of California, Irvine, CA (United States); Beatty, J. J. [The Ohio State Univ., Columbus, OH (United States); Besson, D. Z. [Univ. of Kansas, Lawrence, KS (United States); Binns, W. R. [Washington Univ., St. Louis, MO (United States); Chen, C. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Chen, P. [SLAC National Accelerator Lab., Menlo Park, CA (United States); NASA Goddard Space Flight Center, Greenbelt, MD (United States); Clem, J. M. [Univ. of Delaware, Newark, DE (United States); Connolly, A. [Univ. College London, London (United Kingdom); Dowkontt, P. F. [Washington Univ., St. Louis, MO (United States); DuVernois, M. A. [Univ. of Minnesota, Minneapolis, MN (United States); Field, R. C. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Goldstein, D. [Univ. of California, Irvine, CA (United States); Goodhue, A. [Univ. of California, Los Angeles, CA (United States); Hast, C. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Hebert, C. L. [Univ. of Hawaii, Manoa, HI (United States); Hoover, S. [Univ. of California, Los Angeles, CA (United States); Israel, M. H. [Washington Univ., St. Louis, MO (United States); Learned, J. G. [Univ. of Hawaii, Manoa, HI (United States). et al.

    2009-05-23

    In this article, we present a comprehensive report on the experimental details of the Antarctic Impulsive Transient Antenna (ANITA) long-duration balloon payload, including the design philosophy and realization, physics simulations, performance of the instrument during its first Antarctic flight completed in January of 2007, and expectations for the limiting neutrino detection sensitivity.

  19. Computational tools and lattice design for the PEP-II B-Factory

    International Nuclear Information System (INIS)

    Cai, Y.; Irwin, J.; Nosochkov, Y.; Yan, Y.

    1997-01-01

    Several accelerator codes were used to design the PEP-II lattices, ranging from matrix-based codes, such as MAD and DIMAD, to symplectic-integrator codes, such as TRACY and DESPOT. In addition to element-by-element tracking, we constructed maps to determine aberration strengths. Furthermore, we have developed a fast and reliable method (nPB tracking) to track particles with a one-turn map. This new technique allows us to evaluate performance of the lattices on the entire tune-plane. Recently, we designed and implemented an object-oriented code in C++ called LEGO which integrates and expands upon TRACY and DESPOT. copyright 1997 American Institute of Physics

  20. Removing lead from metallic mixture of waste printed circuit boards by vacuum distillation: factorial design and removal mechanism.

    Science.gov (United States)

    Li, Xingang; Gao, Yujie; Ding, Hui

    2013-10-01

    The lead removal from the metallic mixture of waste printed circuit boards by vacuum distillation was optimized using experimental design, and a mathematical model was established to elucidate the removal mechanism. The variables studied in lead evaporation consisted of the chamber pressure, heating temperature, heating time, particle size and initial mass. The low-level chamber pressure was fixed at 0.1 Pa as the operation pressure. The application of two-level factorial design generated a first-order polynomial that agreed well with the data for evaporation efficiency of lead. The heating temperature and heating time exhibited significant effects on the efficiency, which was validated by means of the copper-lead mixture experiments. The optimized operating conditions within the region studied were the chamber pressure of 0.1 Pa, heating temperature of 1023 K and heating time of 120 min. After the conditions were employed to remove lead from the metallic mixture of waste printed circuit boards, the efficiency was 99.97%. The mechanism of the effects was elucidated by mathematical modeling that deals with evaporation, mass transfer and condensation, and can be applied to a wider range of metal removal by vacuum distillation. Copyright © 2013 Elsevier Ltd. All rights reserved.

  1. Enhancement of Solubility of Lamotrigine by Solid Dispersion and Development of Orally Disintegrating Tablets Using 32 Full Factorial Design

    Directory of Open Access Journals (Sweden)

    Jatinderpal Singh

    2015-01-01

    Full Text Available Present investigation deals with the preparation and evaluation of orally disintegrating tablets (ODTs of lamotrigine using β-cyclodextrin and PVP-K30 as polymers for the preparation of solid dispersion which help in enhancement of aqueous solubility of this BCS CLASS-II drug and sodium starch glycolate (SSG and crospovidone as a superdisintegrating agent, to reduce disintegration time. The ODTs were prepared by direct compression method. Nine formulations were developed with different ratios of superdisintegrating agents. All the formulations were evaluated for disintegration time, weight variation, hardness, friability, drug content uniformity, wetting time, and in vitro drug release study. In vitro drug release study was performed using United States Pharmacopoeia (USP type 2 dissolution test apparatus employing paddle stirrer at 50 rpm using 900 mL of 0.1 N HCl maintained at 37°C ± 0.5°C as the dissolution medium. On the basis of evaluation parameters formulations were prepared using β-CD 1 : 1 solid dispersion. Then 32 full factorial design was applied using SSG and crospovidone in different ratios suggested by using design expert 8.0.7.1 and optimized formulation was prepared using amount of SSG and crospovidone as suggested by the software. The optimized formulation prepared had disintegrating time of 15 s, wetting time of 24 s, and % friability of 0.55.

  2. High-power RF window design for the PEP-II B Factory

    International Nuclear Information System (INIS)

    Neubauer, M.; Hodgson, J.; Ng, C.; Schwarz, H.; Skarpaas, K.; Kroll, N.; Rimmer, R.

    1994-06-01

    We describe the design of RF windows to transmit up to 500 kW CW to the PEP-II 476 MHz cavities. RF analysis of the windows using high-frequency simulation codes are described. These provide information about the power loss distribution in the ceramic and tim matching properties of the structure. Finite-element analyses of the resulting temperature distribution and thermal stresses are presented. Fabrication methods including a proposed scheme to compensate for thermal expansion s are discussed and hardware tests to validate this approach are described. The effects of surface coatings (intentional and otherwise) and the application of air cooling are considered

  3. Physics and design issues of asymmetric storage ring colliders as B-factories

    International Nuclear Information System (INIS)

    Chattopadhyay, S.

    1989-08-01

    This paper concentrates on generic R ampersand D and design issues of asymmetric colliders via a specific example, namely a 9 GeV x 3 GeV collider based on PEP at SLAC. An asymmetric e + -e - collider at the Y(4s) and with sufficiently high luminosity (10 33 -10 34 cm -2 s -1 ) offers the possibility of studying mixing, rare decays, and CP violation in the B bar B meson system, as well as ''beautiful'' tau-charm physics, and has certain qualitative advantages from detection and machine design points of view. These include: the energy constraint; clean environment (∼25% B + B - , B 0 bar B 0 ); large cross section (1 nb); vertex reconstruction (from the time development of space-time separated B and bar B decays due to moving center-of-mass); reduced backgrounds; greatest sensitivity to CP violation in B → CP eigenstate; the possibility of using higher collision frequencies, up to 100 MHz, in a head-on colliding mode using magnetic separation. It is estimated that for B → ΨK s , an asymmetric collider has an advantage equivalent to a factor of five in luminosity relative to a symmetric one. There are, however, questions with regard to the physics of the asymmetric beam-beam coulomb interaction that may limit the intrinsic luminosity and the possibility of realizing the small beam pipes necessary to determine the vertices. 16 refs., 2 figs

  4. Design and performance of a compact scanning transmission X-ray microscope at the Photon Factory

    Energy Technology Data Exchange (ETDEWEB)

    Takeichi, Y., E-mail: yasuo.takeichi@kek.jp; Mase, K.; Ono, K. [Institute of Materials Structure Science, High Energy Accelerator Research Organization, 1-1 Oho, Tsukuba 305-0801 (Japan); Department of Materials Structure Science, SOKENDAI (The Graduate University for Advanced Studies), 1-1 Oho, Tsukuba 305-0801 (Japan); Inami, N. [Institute of Materials Structure Science, High Energy Accelerator Research Organization, 1-1 Oho, Tsukuba 305-0801 (Japan); Suga, H. [Department of Earth and Planetary Systems Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526 (Japan); Miyamoto, C. [Department of Earth and Planetary Systems Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku 113-0033 (Japan); Ueno, T. [National Institute for Materials Science, 1-2-1 Sengen, Tsukuba 305-0047 (Japan); Takahashi, Y. [Institute of Materials Structure Science, High Energy Accelerator Research Organization, 1-1 Oho, Tsukuba 305-0801 (Japan); Department of Earth and Planetary Systems Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526 (Japan); Department of Earth and Planetary Systems Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku 113-0033 (Japan)

    2016-01-15

    We present a new compact instrument designed for scanning transmission X-ray microscopy. It has piezo-driven linear stages, making it small and light. Optical components from the virtual source point to the detector are located on a single optical table, resulting in a portable instrument that can be operated at a general-purpose spectroscopy beamline without requiring any major reconstruction. Careful consideration has been given to solving the vibration problem common to high-resolution microscopy, so as not to affect the spatial resolution determined by the Fresnel zone plate. Results on bacteriogenic iron oxides, single particle aerosols, and rare-earth permanent magnets are presented as examples of its performance under diverse applications.

  5. Optimizing flurbiprofen-loaded NLC by central composite factorial design for ocular delivery

    Science.gov (United States)

    Gonzalez-Mira, E.; Egea, M. A.; Souto, E. B.; Calpena, A. C.; García, M. L.

    2011-01-01

    The purpose of this study was to design and optimize a new topical delivery system for ocular administration of flurbiprofen (FB), based on lipid nanoparticles. These particles, called nanostructured lipid carriers (NLC), were composed of a fatty acid (stearic acid (SA)) as the solid lipid and a mixture of Miglyol® 812 and castor oil (CO) as the liquid lipids, prepared by the hot high pressure homogenization method. After selecting the critical variables influencing the physicochemical characteristics of the NLC (the liquid lipid (i.e. oil) concentration with respect to the total lipid (cOil/L (wt%)), the surfactant and the flurbiprofen concentration, on particle size, polydispersity index and encapsulation efficiency), a three-factor five-level central rotatable composite design was employed to plan and perform the experiments. Morphological examination, crystallinity and stability studies were also performed to accomplish the optimization study. The results showed that increasing cOil/L (wt%) was followed by an enhanced tendency to produce smaller particles, but the liquid to solid lipid proportion should not exceed 30 wt% due to destabilization problems. Therefore, a 70:30 ratio of SA to oil (miglyol + CO) was selected to develop an optimal NLC formulation. The smaller particles obtained when increasing surfactant concentration led to the selection of 3.2 wt% of Tween® 80 (non-ionic surfactant). The positive effect of the increase in FB concentration on the encapsulation efficiency (EE) and its total solubilization in the lipid matrix led to the selection of 0.25 wt% of FB in the formulation. The optimal NLC showed an appropriate average size for ophthalmic administration (228.3 nm) with a narrow size distribution (0.156), negatively charged surface (-33.3 mV) and high EE (~90%). The in vitro experiments proved that sustained release FB was achieved using NLC as drug carriers. Optimal NLC formulation did not show toxicity on ocular tissues.

  6. Optimizing flurbiprofen-loaded NLC by central composite factorial design for ocular delivery

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez-Mira, E; Egea, M A; Garcia, M L [Department of Physical Chemistry, Faculty of Pharmacy, Institute of Nanoscience and Nanotechnology, University of Barcelona, Avenida Joan XXIII s/n, E-08028 Barcelona (Spain); Souto, E B [Faculty of Health Sciences, Fernando Pessoa University, Rua Carlos da Maia, Nr. 296, Office S.1, P-4200-150 Porto (Portugal); Calpena, A C, E-mail: eligonzalezmi@ub.edu [Department of Biopharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Barcelona, Avenida Joan XXIII s/n, E-08028 Barcelona (Spain)

    2011-01-28

    The purpose of this study was to design and optimize a new topical delivery system for ocular administration of flurbiprofen (FB), based on lipid nanoparticles. These particles, called nanostructured lipid carriers (NLC), were composed of a fatty acid (stearic acid (SA)) as the solid lipid and a mixture of Miglyol 812 and castor oil (CO) as the liquid lipids, prepared by the hot high pressure homogenization method. After selecting the critical variables influencing the physicochemical characteristics of the NLC (the liquid lipid (i.e. oil) concentration with respect to the total lipid (cOil/L (wt%)), the surfactant and the flurbiprofen concentration, on particle size, polydispersity index and encapsulation efficiency), a three-factor five-level central rotatable composite design was employed to plan and perform the experiments. Morphological examination, crystallinity and stability studies were also performed to accomplish the optimization study. The results showed that increasing cOil/L (wt%) was followed by an enhanced tendency to produce smaller particles, but the liquid to solid lipid proportion should not exceed 30 wt% due to destabilization problems. Therefore, a 70:30 ratio of SA to oil (miglyol + CO) was selected to develop an optimal NLC formulation. The smaller particles obtained when increasing surfactant concentration led to the selection of 3.2 wt% of Tween 80 (non-ionic surfactant). The positive effect of the increase in FB concentration on the encapsulation efficiency (EE) and its total solubilization in the lipid matrix led to the selection of 0.25 wt% of FB in the formulation. The optimal NLC showed an appropriate average size for ophthalmic administration (228.3 nm) with a narrow size distribution (0.156), negatively charged surface (-33.3 mV) and high EE ({approx}90%). The in vitro experiments proved that sustained release FB was achieved using NLC as drug carriers. Optimal NLC formulation did not show toxicity on ocular tissues.

  7. Optimizing flurbiprofen-loaded NLC by central composite factorial design for ocular delivery

    International Nuclear Information System (INIS)

    Gonzalez-Mira, E; Egea, M A; Garcia, M L; Souto, E B; Calpena, A C

    2011-01-01

    The purpose of this study was to design and optimize a new topical delivery system for ocular administration of flurbiprofen (FB), based on lipid nanoparticles. These particles, called nanostructured lipid carriers (NLC), were composed of a fatty acid (stearic acid (SA)) as the solid lipid and a mixture of Miglyol 812 and castor oil (CO) as the liquid lipids, prepared by the hot high pressure homogenization method. After selecting the critical variables influencing the physicochemical characteristics of the NLC (the liquid lipid (i.e. oil) concentration with respect to the total lipid (cOil/L (wt%)), the surfactant and the flurbiprofen concentration, on particle size, polydispersity index and encapsulation efficiency), a three-factor five-level central rotatable composite design was employed to plan and perform the experiments. Morphological examination, crystallinity and stability studies were also performed to accomplish the optimization study. The results showed that increasing cOil/L (wt%) was followed by an enhanced tendency to produce smaller particles, but the liquid to solid lipid proportion should not exceed 30 wt% due to destabilization problems. Therefore, a 70:30 ratio of SA to oil (miglyol + CO) was selected to develop an optimal NLC formulation. The smaller particles obtained when increasing surfactant concentration led to the selection of 3.2 wt% of Tween 80 (non-ionic surfactant). The positive effect of the increase in FB concentration on the encapsulation efficiency (EE) and its total solubilization in the lipid matrix led to the selection of 0.25 wt% of FB in the formulation. The optimal NLC showed an appropriate average size for ophthalmic administration (228.3 nm) with a narrow size distribution (0.156), negatively charged surface (-33.3 mV) and high EE (∼90%). The in vitro experiments proved that sustained release FB was achieved using NLC as drug carriers. Optimal NLC formulation did not show toxicity on ocular tissues.

  8. Approach to improve the productivity of bioactive compounds of the cyanobacterium Anabaena oryzae using factorial design

    Directory of Open Access Journals (Sweden)

    Ragaa A. Hamouda

    2017-09-01

    Full Text Available Cyanobacteria are one of the richest sources of biomedical relevant compounds with extensive therapeutic pharmaceutical applications and are also known as producer of intracellular and extracellular metabolites with diverse biological activities. The genus Anabaena sp. is known to produce antimicrobial compounds, like phycocyanin and others. The goal of this study was to optimize the production of these bioactive compounds. The Plackett–Burman experimental design was used to screen and evaluate the important medium components that influence the production of bioactive compounds. In this present study, eight independent factors including NaNO3, K2HPO4, MgSO4·7H2O, CaCl2, citric acid, ammonium ferric citrate, ethylene diamine tetraacetic acid disodium magnesium salt (EDTA-Na2Mg and Na2CO3 were surveyed and the effective variables for algal components production of Anabaena oryzae were determined using two-levels Plackett–Burman design. Results analysis showed that the best medium components were NaNO3 (2.25 g l−1; K2HPO4 (0.02 g l−1; MgSO4 (0.0375 g l−1; CaCl2 (0.018 g l−1; citric acid (0.009 g l−1; ammonium ferric citrate (0.009 g l−1 and EDTA-Na2 (0.0015 g l−1 respectively. The total chlorophyll-a, carotenoids, phenol, tannic acid and flavonoid contents in crude extract of Anabaena oryzae were determined. They were 47.7, 4.11, 0.256, 1.046 and 1.83 μg/ml, respectively. The antioxidant capacity was 62.81%.

  9. Atmospheric Neutrinos in the MINOS Far Detector

    Energy Technology Data Exchange (ETDEWEB)

    Howcroft, Caius Leo Frederick [Univ. of Cambridge (United Kingdom)

    2004-12-01

    The phenomenon of flavour oscillations of neutrinos created in the atmosphere was first reported by the Super-Kamiokande collaboration in 1998 and since then has been confirmed by Soudan 2 and MACRO. The MINOS Far Detector is the first magnetized neutrino detector able to study atmospheric neutrino oscillations. Although it was designed to detect neutrinos from the NuMI beam, it provides a unique opportunity to measure the oscillation parameters for neutrinos and anti-neutrinos independently. The MINOS Far Detector was completed in August 2003 and since then has collected 2.52 kton-years of atmospheric data. Atmospheric neutrino interactions contained within the volume of the detector are separated from the dominant background from cosmic ray muons. Thirty seven events are selected with an estimated background contamination of less than 10%. Using the detector's magnetic field, 17 neutrino events and 6 anti-neutrino events are identified, 14 events have ambiguous charge. The neutrino oscillation parameters for vμ and $\\bar{v}$μ are studied using a maximum likelihood analysis. The measurement does not place constraining limits on the neutrino oscillation parameters due to the limited statistics of the data set analysed. However, this thesis represents the first observation of charge separated atmospheric neutrino interactions. It also details the techniques developed to perform atmospheric neutrino analyses in the MINOS Far Detector.

  10. Literature in Focus Beta Beams: Neutrino Beams

    CERN Document Server

    2009-01-01

    By Mats Lindroos (CERN) and Mauro Mezzetto (INFN Padova, Italy) Imperial Press, 2009 The beta-beam concept for the generation of electron neutrino beams was first proposed by Piero Zucchelli in 2002. The idea created quite a stir, challenging the idea that intense neutrino beams only could be produced from the decay of pions or muons in classical neutrino beams facilities or in future neutrino factories. The concept initially struggled to make an impact but the hard work by many machine physicists, phenomenologists and theoreticians over the last five years has won the beta-beam a well-earned position as one of the frontrunners for a possible future world laboratory for high intensity neutrino oscillation physics. This is the first complete monograph on the beta-beam concept. The book describes both technical aspects and experimental aspects of the beta-beam, providing students and scientists with an insight into the possibilities o...

  11. Smart Factory

    DEFF Research Database (Denmark)

    Bilberg, Arne; Radziwon, Agnieszka; Grube Hansen, David

    2017-01-01

    their innovation and competitive advantage by focusing at their competences, strengths and opportunities. The project suggests innovative solutions and business models through collaboration and use of new technologies. In the Smart Factory, SMEs should be able to collaborate on new products, markets and production......, and to target their challenges and ensure sustainable growth and business in these enterprises. Therefore the focus of the Smart Factory project was to support the growth and sustainable development of the small and medium sized manufacturing industry in Denmark. The project focused on SMEs and how to improve......A large part of Danish Industry is based on Small and Medium Sized Enterprises (SMEs), which account for –99% of the companies in Denmark and about two third of the job positions (source: statistikbanken.dk) . That is why, it is so important also to focus research and development at SMEs...

  12. Biosurfactant production by Pseudomonas aeruginosa MSIC02 in cashew apple juice using a 24 full factorial experimental design

    Directory of Open Access Journals (Sweden)

    Rocha Maria Valderez Ponte

    2014-01-01

    Full Text Available In this work, the production of biosurfactants from cashew apple juice by P. aeruginosa MSIC02 was investigate by carrying out a 24 full factorial experimental design, using temperature, glucose concentration from cashew apple juice, phosphorous concentration and cultivation time as variables. The response variable was the percentage of reduction in surface tension in the cell-free culture medium, since it indicates the surface-active agent production. Maximum biosurfactant production, equivalent to a 58% reduction in surface tension, was obtained at 37°C, with glucose concentration of 5.0 g/L and no phosphorous supplementation. Surface tension reduction was significant, since low values were observed in the cell-free medium (27.50 dyne/cm, indicating that biosurfactant was produced. The biosurfactant emulsified different hydrophobic sources and showed stability in the face of salinity, exposure to high temperatures and extreme pH conditions. These physiochemical properties demonstrate the potential for using biosurfactants produced by P. aeruginosa MSIC02 in various applications.

  13. The Optimization of the Oiling Bath Cosmetic Composition Containing Rapeseed Phospholipids and Grapeseed Oil by the Full Factorial Design

    Directory of Open Access Journals (Sweden)

    Michał Górecki

    2015-04-01

    Full Text Available The proper condition of hydrolipid mantle and the stratum corneum intercellular matrix determines effective protection against transepidermal water loss (TEWL. Some chemicals, improper use of cosmetics, poor hygiene, old age and some diseases causes disorder in the mentioned structures and leads to TEWL increase. The aim of this study was to obtain the optimal formulation composition of an oiling bath cosmetic based on rapeseed phospholipids and vegetable oil with high content of polyunsaturated fatty acids. In this work, the composition of oiling bath form was calculated and the degree of oil dispersion after mixing the bath preparation with water was selected as the objective function in the optimizing procedure. The full factorial design 23 in the study was used. The concentrations of rapeseed lecithin ethanol soluble fraction (LESF, alcohol (E and non-ionic emulsifier (P were optimized. Based on the calculations from our results, the optimal composition of oiling bath cosmetic was: L (LESF 5.0 g, E (anhydrous ethanol 20.0 g and P (Polysorbate 85 1.5 g. The optimization procedure used in the study allowed to obtain the oiling bath cosmetic which gives above 60% higher emulsion dispersion degree 5.001 × 10−5 cm−1 compared to the initial formulation composition with the 3.096 × 10−5 cm−1.

  14. Analysis of transmission properties in an indoor wireless sensor network based on a full-factorial design

    International Nuclear Information System (INIS)

    Christmann, Dennis; Martinovic, Ivan; Schmitt, Jens B

    2010-01-01

    In this paper, we systematically investigate different factors and their effects on the wireless transmission properties using a full-factorial experimental design of a wireless sensor network in a real-world indoor environment. We quantify the impact of primary factors such as the wireless channel, physical position, transmission power and line of sight, as well as their interactions on the received signal strength (RSS). While some of our results support conventional assumptions, this study also shows that there are several properties which are in contrast to existing findings. For example, there is no significant correlation in the measured RSS between differently located but equally distant transmitters, yet the correlation coefficient for the two directions of a single link between two transmitters is above 94%, leading to very symmetric links that differ only in a few dBm for the two directions. Further analysis reveals the strong interaction of transmission frequency and physical position, while the transmission power has only an isolated, non-interacting effect on the RSS. Since the analyzed network consists of commodity motes utilizing TI's well-known IEEE 802.15.4 compliant CC2420 transceiver, the results of this experimental analysis can serve as valuable insights in planning and deploying wireless sensor networks in different application scenarios

  15. Formulation and Optimization of Lansoprazole Pellets Using Factorial Design Prepared by Extrusion-Spheronization Technique Using Carboxymethyl Tamarind Kernel Powder.

    Science.gov (United States)

    Muley, Sagar Sopanrao; Nandgude, Tanaji; Poddar, Sushilkumar

    2017-01-01

    In the present study, Lansoprazole pellets were prepared employing a novel excipient Carboxymethyl tamarind kernel powder (CMTKP) using extrusion-spheronization technique. Various research studies including patents have been carried out on this polymer. Pellet formulation was optimized for formulation parameters (concentration of microcrystalline cellulose, CMTKP, croscarmellose sodium and isopropyl alcohol). Process parameters (speed and duration of spheronization) were optimized using factorial design. The pellets were evaluated for yield, bulk and tapped density, particle size, hardness, drug content, disintegration time and drug release. The optimized batch showed 93.53% yield, 0.307 kg/cm2 hardness, 2.15 mm average particle size, 292 sec disintegration time and 90.46% drug content. Drug release of the optimized batch (2F7) and marketed formulation (LANZOL cap) was found to be 82.33% and 80.07%, respectively. An accelerated study indicated that optimized formulation was stable. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  16. Enhancing EPA Content in an Arctic Diatom: A Factorial Design Study to Evaluate Interactive Effects of Growth Factors

    Directory of Open Access Journals (Sweden)

    Pia Steinrücken

    2018-04-01

    Full Text Available Microalgae with a high content of the omega-3 polyunsaturated fatty acids (PUFAs, eicosapentaenoic acid (EPA, and docosahexaenoic acid (DHA are of great demand for microalgae-based technologies. An Arctic strain of the diatom Attheya septentrionalis was shown in previous experiments to increase its EPA content from 3.0 to 4.6% of dry weight (DW in the nutrient-replete exponential phase and nutrient-depleted stationary phase, respectively. In the present study, a factorial-design experiment was used, to investigate this effect in more detail and in combination with varying salinities and irradiances. A mathematical model revealed that both growth phase and salinity, alone and in combination, influenced the EPA content significantly. Maximum EPA values of 7.1% DW were obtained at a salinity of 22 and after 5 days in stationary phase, and might be related to a decreased silica content, an accumulation of storage lipids containing EPA, or both. However, growth rates were lower for low salinity (0.54 and 0.57 d−1 than high salinity (0.77 and 0.98 d−1 cultures.

  17. Background species effect on aqueous arsenic removal by nano zero-valent iron using fractional factorial design.

    Science.gov (United States)

    Tanboonchuy, Visanu; Grisdanurak, Nurak; Liao, Chih-Hsiang

    2012-02-29

    This study describes the removal of arsenic species in groundwater by nano zero-valent iron process, including As(III) and As(V). Since the background species may inhibit or promote arsenic removal. The influence of several common ions such as phosphate (PO4(3-)), bicarbonate (HCO3-)), sulfate (SO4(2-)), calcium (Ca2+), chloride (Cl-), and humic acid (HA) were selected to evaluate their effects on arsenic removal. In particular, a 2(6-2) fractional factorial design (FFD) was employed to identify major or interacting factors, which affect arsenic removal in a significant way. As a result of FFD evaluation, PO4(3-) and HA play the role of inhibiting arsenic removal, while Ca2+ was observed to play the promoting one. As for HCO3- and Cl-, the former one inhibits As(III) removal, whereas the later one enhances its removal; on the other hand, As(V) removal was affected only slightly in the presence of HCO3- or Cl-. Hence, it was suggested that the arsenic removal by the nanoiron process can be improved through pretreatment of PO4(3-) and HA. In addition, for the groundwater with high hardness, the nanoiron process can be an advantageous option because of enhancing characteristics of Ca2+. Copyright © 2011 Elsevier B.V. All rights reserved.

  18. Fractional Factorial Design Study on the Performance of GAC-Enhanced Electrocoagulation Process Involved in Color Removal from Dye Solutions

    Directory of Open Access Journals (Sweden)

    Iuliana Gabriela Breaban

    2013-07-01

    Full Text Available The aim of this study was to determine the effects of main factors and interactions on the color removal performance from dye solutions using the electrocoagulation process enhanced by adsorption on Granular Activated Carbon (GAC. In this study, a mathematical approach was conducted using a two-level fractional factorial design (FFD for a given dye solution. Three textile dyes: Acid Blue 74, Basic Red 1, and Reactive Black 5 were used. Experimental factors used and their respective levels were: current density (2.73 or 27.32 A/m2, initial pH of aqueous dye solution (3 or 9, electrocoagulation time (20 or 180 min, GAC dose (0.1 or 0.5 g/L, support electrolyte (2 or 50 mM, initial dye concentration (0.05 or 0.25 g/L and current type (Direct Current—DC or Alternative Pulsed Current—APC. GAC-enhanced electrocoagulation performance was analyzed statistically in terms of removal efficiency, electrical energy, and electrode material consumptions, using modeling polynomial equations. The statistical significance of GAC dose level on the performance of GAC enhanced electrocoagulation and the experimental conditions that favor the process operation of electrocoagulation in APC regime were determined. The local optimal experimental conditions were established using a multi-objective desirability function method.

  19. Process improvement approach to the acid activation of smectite using factorial and orthogonal central composite design methods

    Directory of Open Access Journals (Sweden)

    SRDJAN PETROVIC

    2008-04-01

    Full Text Available The purpose of this study was to determine the effective operating parameters and the optimum operating conditions of an acid activation process within the framework of improvement of the process. Full two-level factorial and orthogonal central composite design methods were used successively. The examined parameters were the main and interaction effects of temperature, leaching time, acid normality, solid-to-liquid ratio and stirring rate. The selected process response was the leaching yield of the MgO content because Mg is the element most readily removed from the octahedral sheet, which affects the tendency for activation. Statistical regression analysis and analysis of variance were applied to the experimental data to develop a predictive model, which revealed that temperature, leaching time and acid normality exert the strongest influence on the specific surface area of smectite, whilst the solid-to-liquid ratio and the stirring rate have a secondary effect. Furthermore, the highest leaching yield of MgO was found to be 41.86 %, which is responsible for the increase in the specific surface area of up to 221 m2 g-1.

  20. Design of the 150 kW, 46-62 MHz power amplifier for the TRIUMF KAON factory booster ring

    International Nuclear Information System (INIS)

    Kwiatkowski, S.; Enegren, T.; Poirier, R.L.

    1988-06-01

    The rf amplifiers for the KAON Factory booster ring must be capable of reactively compensating (detuning) for the injected/extracted beam load as well as providing the beam power and the cavity losses. In order to insure the stability of the rf system under heavy transient and steady state beam loading conditions it is necessary to equip the power amplifiers with fast rf feedback with sufficient gain and bandwidth to reduce the apparent Q of the rf amplifier system as seen by the beam and the other feedback loops. The maximum gain and bandwidth of such a feedback loop is limited by the propagation delay around the feedback path. To minimize the propagation delay a 2.4 kW two stage solid state driver will be used to drive the cathode of the Eimac Y567B tetrode to give an overall propagation delay less than 30 nS. The design features of the rf amplifier to meet the above conditions will be described and test results reported. (Author) (7 refs., 7 figs.)

  1. Fractional Factorial Design Study on the Performance of GAC-Enhanced Electrocoagulation Process Involved in Color Removal from Dye Solutions.

    Science.gov (United States)

    Secula, Marius Sebastian; Cretescu, Igor; Cagnon, Benoit; Manea, Liliana Rozemarie; Stan, Corneliu Sergiu; Breaban, Iuliana Gabriela

    2013-07-10

    The aim of this study was to determine the effects of main factors and interactions on the color removal performance from dye solutions using the electrocoagulation process enhanced by adsorption on Granular Activated Carbon (GAC). In this study, a mathematical approach was conducted using a two-level fractional factorial design ( FFD ) for a given dye solution. Three textile dyes: Acid Blue 74, Basic Red 1, and Reactive Black 5 were used. Experimental factors used and their respective levels were: current density (2.73 or 27.32 A/m²), initial pH of aqueous dye solution (3 or 9), electrocoagulation time (20 or 180 min), GAC dose (0.1 or 0.5 g/L), support electrolyte (2 or 50 mM), initial dye concentration (0.05 or 0.25 g/L) and current type (Direct Current- DC or Alternative Pulsed Current- APC ). GAC-enhanced electrocoagulation performance was analyzed statistically in terms of removal efficiency, electrical energy, and electrode material consumptions, using modeling polynomial equations. The statistical significance of GAC dose level on the performance of GAC enhanced electrocoagulation and the experimental conditions that favor the process operation of electrocoagulation in APC regime were determined. The local optimal experimental conditions were established using a multi-objective desirability function method.

  2. Spray drying of budesonide, formoterol fumarate and their composites-II. Statistical factorial design and in vitro deposition properties.

    Science.gov (United States)

    Tajber, L; Corrigan, O I; Healy, A M

    2009-02-09

    The aim of this study was to investigate the effect of changing spray drying parameters on the production of a budesonide/formoterol fumarate 100:6 (w/w) composite. The systems were spray dried as solutions from 95% ethanol/5% water (v/v) using a Büchi 191-Mini Spray Dryer. A 2(5-1) factorial design study was undertaken to assess the consequence of altering spray drying processing variables on particle characteristics. The processing parameters that were studied were inlet temperature, spray drier airflow rate, pump rate, aspirator setting and feed concentration. Each batch of the resulting powder was characterised in terms of thermal and micromeritic properties as well as an in vitro deposition by twin impinger analysis. Overall, the parameter that had the greatest influence on each response investigated was production yield - airflow (higher airflow giving greater yields), median particle size - airflow (higher airflow giving smaller particle sizes) and Carr's compressibility index - feed concentration (lower feed concentration giving smaller Carr's indices). A six- to seven-fold difference in respirable fraction can be observed by changing the spray drying process parameters. The co-spray dried composite system which displayed best in vitro deposition characteristics, showed a 2.6-fold increase in respirable fraction in the twin impinger experiments and better dose uniformity compared with the physical mix of micronised powders.

  3. Development and optimization of enteric coated mucoadhesive microspheres of duloxetine hydrochloride using 3(2) full factorial design.

    Science.gov (United States)

    Setia, Anupama; Kansal, Sahil; Goyal, Naveen

    2013-07-01

    Microspheres constitute an important part of oral drug delivery system by virtue of their small size and efficient carrier capacity. However, the success of these microspheres is limited due to their short residence time at the site of absorption. The objective of the present study was to formulate and systematically evaluate in vitro performance of enteric coated mucoadhesive microspheres of duloxetine hydrochloride (DLX), an acid labile drug. DLX microspheres were prepared by simple emulsification phase separation technique using chitosan as carrier and glutaraldehyde as a cross-linking agent. Microspheres prepared were coated with eudragit L-100 using an oil-in-oil solvent evaporation method. Eudragit L-100was used as enteric coating polymer with the aim to release the drug in small intestine The microspheres prepared were characterized by particle size, entrapment efficiency, swelling index (SI), mucoadhesion time, in vitro drug release and surface morphology. A 3(2) full factorial design was employed to study the effect of independent variables polymer-to-drug ratio (X1) and stirring speed (X2) on dependent variables, particle size, entrapment efficiency, SI, in vitro mucoadhesion and drug release up to 24 h (t24). Microspheres formed were discrete, spherical and free flowing. The microspheres exhibited good mucoadhesive property and also showed high percentage entrapment efficiency. The microspheres were able to sustain the drug release up to 24 h. Thus, the prepared enteric coated mucoadhesive microspheres may prove to be a potential controlled release formulation of DLX for oral administration.

  4. Development of hydroethanolic extract of Ipomoea pes-caprae using factorial design followed by antinociceptive and anti-inflammatory evaluation

    Directory of Open Access Journals (Sweden)

    Daniela Vieira

    2012-11-01

    Full Text Available Ipomoea pes-caprae (L. R. Br., Convolvulaceae, is a medicinal plant that grows abundantly as a pan-tropical stand plant. The 3² (two factors and three levels factorial design, was applied to determine the best time and drug/solvent proportion to maximize the flavonoid content in the hydroethanolic extract by maceration process. The antinociceptive and anti-inflammatory effects were studied at 5-20 mg/kg, i.p., using the writhing test and carrageenan-induced pleurisy models in mice. The optimized extract was able to inhibit more than 50% of abdominal writhing at 20 mg/kg, with 55.88%±2.4 of maximum inhibition. Indomethacin, used as positive control, inhibited 64.86% at 10 mg/kg. In the pleurisy model, the extract produced dose-dependent inhibition of the first phase of inflammation (4 h in the pleural cavity induced by injection of carrageenan (1% in mice. It inhibited 50%±0.82 (p<0.01 of exudation induced by carrageenan, and 60.88%±0.14 (p<0.01 of leukocyte migration to the pleural cavity. In conclusion, the results validate the technological conditions of the maceration process to produce an optimized bioactive herb extract for the development of analgesic and anti-inflammatory phytopharmaceuticals using 70 ºGL ethanol, a plant to solvent ratio of 12.5% (w/v, and ten days of maceration.

  5. Solar neutrinos

    International Nuclear Information System (INIS)

    Schatzman, E.

    1983-01-01

    The solar energy is produced by a series of nuclear reactions taking place in the deep interior of the sun. Some of these reactions produce neutrinos which may be detected, the proper detection system being available. The results of the Davis experiment (with 37 Cl) are given, showing a deficiency in the solar neutrino flux. The relevant explanation is either a property of the neutrino or an important change in the physics of the solar models. The prospect of a new experiment (with 71 Ga) is important as it will decide which of the two explanations is correct [fr

  6. Full‐factorial design space exploration approach for multi‐criteria decision making of the design of industrial halls

    NARCIS (Netherlands)

    Lee, B. (Bruno); Pourmousavian, N. (Navid); Hensen, J.L.M.

    2016-01-01

    Industrial halls pose high energy saving potential that is not yet explored under current design practice. Common design approaches such as parametric study or optimization are largely constrained by the assumptions and do not promote flexibility in the decision making process. Based on the unique

  7. The TRIUMF KAON Factory

    International Nuclear Information System (INIS)

    Craddock, M.

    1989-05-01

    TRIUMF has been awarded $11M for a one-year pre-construction Engineering Design and Impact Study of the KAON Factory. This will enable prototypes of many accelerator components to be built and the design of the accelerators and the layout of the experimental areas to be reviewed. The building and tunnel designs will be finalized, environmental, legal and economic impact studies carried out, and international involvement pursued further

  8. B-factory detectors

    International Nuclear Information System (INIS)

    Marlow, D.R.

    2002-01-01

    The designs of the recently commissioned BaBar and Belle B-Factory detectors are described. The discussion is organized around the methods and instruments used to detect the so-called gold-plated-mode B 0 →J/ΨK S decays and related modes

  9. Neutrino sunshine

    Energy Technology Data Exchange (ETDEWEB)

    Fraser, Gordon

    1992-09-15

    Most of the Sun's energy comes from the fusion of protons into deuterium. Sunshine is necessary for life, but the first evidence for the neutrinos which accompany and explain this basic process still makes science history.

  10. Supernova neutrinos

    International Nuclear Information System (INIS)

    John Beacom

    2003-01-01

    We propose that neutrino-proton elastic scattering, ν + p → ν + p, can be used for the detection of supernova neutrinos. Though the proton recoil kinetic energy spectrum is soft, with T p ≅ 2E ν 2 /M p , and the scintillation light output from slow, heavily ionizing protons is quenched, the yield above a realistic threshold is nearly as large as that from (bar ν) e + p → e + + n. In addition, the measured proton spectrum is related to the incident neutrino spectrum, which solves a long-standing problem of how to separately measure the total energy release and temperature of ν μ , ν τ , (bar ν) μ , and (bar ν) τ . The ability to detect this signal would give detectors like KamLAND and Borexino a crucial and unique role in the quest to detect supernova neutrinos

  11. Neutrino cosmology

    CERN Document Server

    Lesgourgues, Julien; Miele, Gennaro; Pastor, Sergio

    2013-01-01

    The role that neutrinos have played in the evolution of the Universe is the focus of one of the most fascinating research areas that has stemmed from the interplay between cosmology, astrophysics and particle physics. In this self-contained book, the authors bring together all aspects of the role of neutrinos in cosmology, spanning from leptogenesis to primordial nucleosynthesis, their role in CMB and structure formation, to the problem of their direct detection. The book starts by guiding the reader through aspects of fundamental neutrino physics, such as the standard cosmological model and the statistical mechanics in the expanding Universe, before discussing the history of neutrinos in chronological order from the very early stages until today. This timely book will interest graduate students and researchers in astrophysics, cosmology and particle physics, who work with either a theoretical or experimental focus.

  12. Neutrino sunshine

    International Nuclear Information System (INIS)

    Fraser, Gordon

    1992-01-01

    Most of the Sun's energy comes from the fusion of protons into deuterium. Sunshine is necessary for life, but the first evidence for the neutrinos which accompany and explain this basic process still makes science history

  13. Neutrino overview

    International Nuclear Information System (INIS)

    Haxton, W.C.

    1994-01-01

    I discuss some of the open issues in neutrino physics, emphasizing areas of intersection with astrophysics, that occupied the participants of the Snowmass Workshop on Nuclear and Particle Astrophysics and Cosmology in the Next Millenium

  14. Neutrino masses and oscillations

    Energy Technology Data Exchange (ETDEWEB)

    Smirnov, A Yu

    1996-11-01

    New effects related to refraction of neutrinos in different media are reviewed and implication of the effects to neutrino mass and mixing are discussed. Patterns of neutrino masses and mixing implied by existing hints/bounds are described. Recent results on neutrino mass generation are presented. They include neutrino masses in SO(10) GUT`s and models with anomalous U(1), generation of neutrino mass via neutrino-neutralino mixing, models of sterile neutrino. (author). 95 refs, 9 figs.

  15. Peer support for family carers of people with dementia, alone or in combination with group reminiscence in a factorial design: study protocol for a randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Wenborn Jennifer

    2011-09-01

    Full Text Available Abstract Background Peer support interventions can improve carer wellbeing and interventions that engage both the carer and person with dementia can have significant mutual benefits. Existing research has been criticised for inadequate rigour of design or reporting. This paper describes the protocol for a complex trial that evaluates one-to-one peer support and a group reminiscence programme, both separately and together, in a factorial design. Design A 2 × 2 factorial multi-site randomised controlled trial of individual peer support and group reminiscence interventions for family carers and people with dementia in community settings in England, addressing both effectiveness and cost-effectiveness. Discussion The methods described in this protocol have implications for research into psychosocial interventions, particularly complex interventions seeking to test both individual and group approaches. Trial Registration ISRCTN37956201

  16. JUNO. Determination of the neutrino mass hierarchy using reactor neutrinos

    Energy Technology Data Exchange (ETDEWEB)

    Wonsak, Bjoern [Hamburg University, Inst. Exp. Phys., Hamburg (Germany)

    2015-07-01

    The Jiangmen Underground Neutrino Observatory (JUNO) is a medium-baseline reactor neutrino experiment located in China. Its aim is to determine the neutrino mass hierarchy at more than 3 sigma significance after six years of data taking by using a 20kt liquid scintillator detector. To achieve this goal, an energy resolution of less than 3%/√(E) is necessary, creating strict requirements on the detector design and the liquid scintillator. Moreover, JUNO will be the only experiment in the near future able to measure the solar mixing parameters with a precision of better than 1%. This is at the same level as our current knowledge on flavour mixing in the quark sector, marking an important milestone of neutrino physics. In addition, supernova neutrinos, geo-neutrinos, sterile neutrinos as well as solar and atmospheric neutrinos can be studied. JUNO was approved in 2013 and the construction of the underground facility started early this year. In this talk the status of the experiment and its prospects is discussed.

  17. Supernova neutrino detection

    International Nuclear Information System (INIS)

    Selvi, M.

    2005-01-01

    Neutrinos emitted during a supernova core collapse represent a unique feature to study both stellar and neutrino properties. After discussing the details of the neutrino emission in the star and the effect of neutrino oscillations on the expected neutrino fluxes at Earth, a review of the detection techniques is presented in this paper, with particular attention to the problem of electron neutrino detection

  18. The OPERA neutrino velocity measurement

    Energy Technology Data Exchange (ETDEWEB)

    Wonsak, Bjoern [Universitaet Hamburg (Germany)

    2012-07-01

    OPERA is a long-baseline neutrino oscillation experiment designed to find tau neutrinos appearing in a pure muon neutrino beam. Recently, a measurement of the flight time of the neutrinos between the CNGS at CERN and the OPERA detector at the LNGS has been performed. It was found that the neutrinos arrive at the detector significantly earlier in time than expected if travelling at the speed of light. In this talk, the main aspects of this measurement are presented, including timing and geodesy issues and the analysis procedure. An update concerning results with a fine structured time distribution of the beam is given, as well as latest information on some additional cross checks.

  19. Neutrino oscillations in dense neutrino gases

    International Nuclear Information System (INIS)

    Samuel, S.

    1993-01-01

    We consider oscillations of neutrinos under conditions in which the neutrino density is sufficiently large that neutrino-neutrino interactions cannot be neglected. A formalism is developed to treat this highly nonlinear system. Numerical analysis reveals a rich array of phenomena. In certain gases, a self-induced Mikheyev-Smirnov-Wolfenstein effect occurs in which electron neutrinos are resonantly converted into muon neutrinos. In another relatively low-density gas, an unexpected parametric resonant conversion takes place. Finally, neutrino-neutrino interactions maintain coherence in one system for which a priori one expected decoherence

  20. Neutrino astronomy with supernova neutrinos

    Science.gov (United States)

    Brdar, Vedran; Lindner, Manfred; Xu, Xun-Jie

    2018-04-01

    Modern neutrino facilities will be able to detect a large number of neutrinos from the next Galactic supernova. We investigate the viability of the triangulation method to locate a core-collapse supernova by employing the neutrino arrival time differences at various detectors. We perform detailed numerical fits in order to determine the uncertainties of these time differences for the cases when the core collapses into a neutron star or a black hole. We provide a global picture by combining all the relevant current and future neutrino detectors. Our findings indicate that in the scenario of a neutron star formation, supernova can be located with precision of 1.5 and 3.5 degrees in declination and right ascension, respectively. For the black hole scenario, sub-degree precision can be reached.

  1. Ibuprofen nanocrystals developed by 22 factorial design experiment: A new approach for poorly water-soluble drugs

    Directory of Open Access Journals (Sweden)

    A.R. Fernandes

    2017-12-01

    Full Text Available The reduction of the particle size of drugs of pharmaceutical interest down to the nano-sized range has dramatically changed their physicochemical properties. The greatest disadvantage of nanocrystals is their inherent instability, due to the risk of crystal growth. Thus, the selection of an appropriate stabilizer is crucial to obtain long-term physicochemically stable nanocrystals. High pressure homogenization has enormous advantages, including the possibility of scaling up, lack of organic solvents and the production of small particles diameter with low polydispersity index. The sequential use of high shear homogenization followed by high pressure homogenization, can modulate nanoparticles’ size for different administration routes. The present study focuses on the optimization of the production process of two formulations composed of different surfactants produced by High Shear Homogenization followed by hot High Pressure Homogenization. To build up the surface response charts, a 22 full factorial design experiment, based on 2 independent variables, was used to develop optimized formulations. The effects of the production process on the mean particle size and polydispersity index were evaluated. The best ibuprofen nanocrystal formulations were obtained using 0.20% Tween 80 and 1.20% PVP K30 (F1 and 0.20% Tween 80 and 1.20% Span 80 (F2. The estimation of the long-term stability of the aqueous suspensions of ibuprofen nanocrystals was studied using the LUMISizer. The calculated instability index suggests that F1 was more stable when stored at 4 °C and 22 °C, whereas F2 was shown to be more stable when freshly prepared.

  2. Factorial experimental design for the optimization of catalytic degradation of malachite green dye in aqueous solution by Fenton process

    Directory of Open Access Journals (Sweden)

    A. Elhalil

    2016-09-01

    Full Text Available This work focuses on the optimization of the catalytic degradation of malachite green dye (MG by Fenton process “Fe2+/H2O2”. A 24 full factorial experimental design was used to evaluate the effects of four factors considered in the optimization of the oxidative process: concentration of MG (X1, concentration of Fe2+ (X2, concentration of H2O2 (X3 and temperature (X4. Individual and interaction effects of the factors that influenced the percentage of dye degradation were tested. The effect of interactions between the four parameters shows that there is a dependency between concentration of MG and concentration of Fe2+; concentration of Fe2+ and concentration of H2O2, expressed by the great values of the coefficient of interaction. The analysis of variance proved that, the concentration of MG, the concentration of Fe2+ and the concentration of H2O2 have an influence on the catalytic degradation while it is not the case for the temperature. In the optimization, the great dependence between observed and predicted degradation efficiency, the correlation coefficient for the model (R2=0.986 and the important value of F-ratio proved the validity of the model. The optimum degradation efficiency of malachite green was 93.83%, when the operational parameters were malachite green concentration of 10 mg/L, Fe2+ concentration of 10 mM, H2O2 concentration of 25.6 mM and temperature of 40 °C.

  3. Parameters Studies on Surface Initiated Rolling Contact Fatigue of Turnout Rails by Three-Level Unreplicated Saturated Factorial Design

    Directory of Open Access Journals (Sweden)

    Xiaochuan Ma

    2018-03-01

    Full Text Available Surface initiated rolling contact fatigue (RCF, mainly characterized by cracks and material stripping, is a common type of damage to turnout rails, which can not only shorten service life of turnout but also lead to poor running safety of vehicle. The rail surface initiated RCF of turnouts is caused by a long-term accumulation, the size and distribution of which are related to the dynamic parameters of the complicated vehicle-turnout system. In order to simulate the accumulation of rail damage, some random samples of dynamic parameters significantly influencing it should be input. Based on the three-level unreplicated saturated factorial design, according to the evaluation methods of H, P and B statistic values, six dynamic parameters that influence the rail surface initiated RCF in turnouts, namely running speed of vehicle, axle load, wheel-rail profiles, integral vertical track stiffness and wheel-rail friction coefficient, are obtained by selecting 13 dynamic parameters significantly influencing the dynamic vehicle-turnout interaction as the analysis factors, considering four dynamic response results, i.e., the normal wheel-rail contact force, longitudinal creep force, lateral creep force and wheel-rail contact patch area as the observed parameters. In addition, the rail surface initiated RCF behavior in turnouts under different wheel-rail creep conditions is analyzed, considering the relative motion of stock/switch rails. The results show that the rail surface initiated RCF is mainly caused by the tangential stress being high under small creep conditions, the normal and tangential stresses being high under large creep conditions, and the normal stress being high under pure spin creep conditions.

  4. Test results of pre-production prototype distributed ion pump design for the PEP-II Asymmetric B-Factory collider

    Energy Technology Data Exchange (ETDEWEB)

    Holdener, F.R.; Behne, D.; Hathaway, D. [and others

    1995-04-24

    We have built and tested a plate-type pre-production distributed Ion Pump (DIP) for the PEP-II B-Factory High Energy Ring (HER). The design has been an earlier design to use less materials and to costs. Penning cell hole sizes of 15, 18, and 21 mm have been tested in a uniform magnetic field of 0.18 T to optimize pumping speed. The resulting final DIP design consisting of a 7-plate, 15 mm basic cell size anode was magnetic field of the HER dipole. A description of the final optimized DIP design will be presented along with the test results of the pumping speed measurements.

  5. Solar neutrino

    Energy Technology Data Exchange (ETDEWEB)

    Sugimoto, D [Tokyo Univ. (Japan). Coll. of General Education

    1975-01-01

    The measurement of solar neutrino was performed by using the reaction /sup 37/cl+..nu..sub(e)..-->../sup 37/Ar+e/sup -/ by Davis et al. The argon gas produced through the above mentioned reaction in a tank containing 610 ton of C/sub 2/Cl/sub 4/ was collected and measured. The rate of production of /sup 37/Ar was 0.13+-0.20/day, and the net production rate by the solar neutrino was 0.06+-0.20/day, being corrected for background. This value corresponds to 0.5+-1.0 SNU. Theoretical calculation with the model of spherically symmetric solar development gave an expected value of 5.6 SNU, which is in contradiction with the experimental value. Reason of this discrepancy was considered. The possibility of decay of neutrino to the other particles with weak interaction is very slight. Various models of the sun were investigated, but the results were still inconsistent with the experiment. The mixing of matters in the sun may cause the reduction of neutrino. If He gas comes to the center of the sun by mixing, the reaction, /sup 3/He+/sup 3/He, progresses excessively at the center, and it produces the expansion of the core of the sun. Then, the temperature drops and the neutrino is reduced. Various models which can explain the neutrino of less than ISNU have been presented. However, other theory says that the reduction of neutrino is not expected even if the mixing is considered. A problem concerning the mixing is whether the thermal instability which causes the mixing exists. (Kato, T.).

  6. Full factorial design applied to the synthesis of Pd-?Ag nanobars by the polyol method and the perspective for ethanol oxidation

    OpenAIRE

    Carrera-Cerritos, Raul; Ponce de Leon, Carlos; Ledesma-Garcia, J.; Fuentes-Ramirez, R.; Arriaga, L.G.

    2014-01-01

    Full factorial design methodology was applied to the synthesis and optimization of Pd–Ag nanobars usingthe polyol process as the reducer. The concentration of Br? ions, the temperature and the reaction timewere selected as factors to study, whereas the yield (% nanobars) was the response to be analyzed. Thenanoparticles were characterized by X-ray diffraction, energy-dispersive X-ray spectroscopy,transmission electron microscopy, high-resolution transmission electron microscopy and X-rayphoto...

  7. Future neutrino oscillation facilities: physics priorities and open issues

    International Nuclear Information System (INIS)

    Blondel, Alain

    2006-01-01

    The recent discovery that neutrinos have masses opens a wide new field of experimentation. Accelerator-made neutrinos are essential in this program. Ideas for future facilities include Superbeam, Beta-beam, or Neutrino Factory, each associated with one or several options for detector systems. We now begin a 'scoping study' aimed at determining a set of key R and D projects enabling the community to propose an ambitious accelerator neutrino program at the turn of this decade. As an introduction to this study, a set of physics priorities, a summary of the perceived virtues and shortcomings of the various options, and a number of open questions are presented

  8. Project 8, Phase III Design: Placing an eV-Scale Limit on the Neutrino Mass using Cyclotron Radiation Emission Spectroscopy

    Science.gov (United States)

    Oblath, Noah; Project 8 Collaboration

    2016-09-01

    We report on the design concept for Phase III of the Project 8 experiment. In the third phase of Project 8 we aim to place a limit on the neutrino mass that is similar to the current limits set by tritium beta-decay experiments, mν radioastronomy will be employed to search for and track electron signals in the fiducial volume. This talk will present the quantitative design concept for the phased-array receiver, and illustrate how we are progressing towards the Phase IV experiment, which will have sensitivity to the neutrino mass scale allowed by the inverted mass hierarchy. This work is supported by the DOE Office of Science Early Career Research Program, and the Laboratory Directed Research and Development Program at Pacific Northwest National Laboratory.

  9. Nuclear physics at the KAON factory

    International Nuclear Information System (INIS)

    Kitching, R.

    1989-05-01

    The author surveys the range of nuclear physics issues which can be addressed with a high intensity hadron facility such as the KAON factory. He discusses hadron spectroscopy, kaon scattering, hypernuclear physics, spin physics, and nuclear physics with neutrinos. Nuclear Physics is defined rather broadly, encompassing the study of strongly interacting systems, and including the structure of individual hadrons, hadron-hadron interactions, hadronic weak and electromagnetic currents (in nuclei too), conventional nuclear structure, and exotic nuclei. The basic theme is how the KAON Factory can shed light on non-perturbative QCD and its relation to conventional nuclear physics

  10. Neutrino book

    International Nuclear Information System (INIS)

    Spiro, Michel

    1995-01-01

    André Rousset's book (in French - Gargamelle et les Courants Neutres - Ecole des Mines de Paris) tells the story of Gargamelle and the discovery at CERN in 1973 of neutral currents, the cornerstone of the electroweak theory. This vital discovery helped to give credence to the Standard Model of particle physics. Rousset is both an observer and one of the key figures in the story. His book is lively and well documented; in it he uses archive material to ensure the accuracy of his information on dates, choices and decisions. After an introduction to particle physics which puts into perspective the electroweak theory unifying weak and electromagnetic interactions, Rousset comes straight to the point. From the late 1950s onwards he was involved in the construction of the first heavy liquid bubble chambers by the BP1, BP2 and BP3 teams at the Ecole Polytechnique in Paris. For Gargamelle a bigger laboratory was needed, and it was at the CEA (French Atomic Energy Commission) in Saclay that the chamber was designed by teams from the Saturne accelerator and the Ecole Polytechnique. However, the decision to build Gargamelle was taken in 1965 through the impetus of André Lagarrigue, in defiance of the normal CERN procedures. Gargamelle was then in competition with the other big bubble chamber project, BEBC; was it really necessary to build two big chambers? The decision by Francis Perrin and the CEA to contribute ''generously'' to the project was probably what swung the decision. Construction took five years, during which many problems were encountered, right up to the fault in the main part of the chamber which caused delays and, a few years later, was to prove fatal to the detector. As Rousset correctly states, Gargamelle was probably the first big detector designed to be built on industrial lines, in direct cooperation with industry. The reward: the first neutrino interaction was photographed on 28 January 1971

  11. Multivariate study of parameters in the determination of pesticide residues in apple by headspace solid phase microextraction coupled to gas chromatography-mass spectrometry using experimental factorial design.

    Science.gov (United States)

    Abdulra'uf, Lukman Bola; Tan, Guan Huat

    2013-12-15

    Solid-phase microextraction (SPME) is a solvent-less sample preparation method which combines sample preparation, isolation, concentration and enrichment into one step. In this study, multivariate strategy was used to determine the significance of the factors affecting the solid phase microextraction of pesticide residues (fenobucarb, diazinon, chlorothalonil and chlorpyrifos) using a randomised factorial design. The interactions and effects of temperature, time and salt addition on the efficiency of the extraction of the pesticide residues were evaluated using 2(3) factorial designs. The analytes were extracted with 100 μm PDMS fibres according to the factorial design matrix and desorbed into a gas chromatography-mass spectrometry detector. The developed method was applied for the analysis of apple samples and the limits of detection were between 0.01 and 0.2 μg kg(-)(1), which were lower than the MRLs for apples. The relative standard deviations (RSD) were between 0.1% and 13.37% with average recovery of 80-105%. The linearity ranges from 0.5-50 μg kg(-)(1) with correlation coefficient greater than 0.99. Copyright © 2013 Elsevier Ltd. All rights reserved.

  12. Design of a Communication Scheme in a Modern Factory in Accordance with the Standard of Industry 4.0

    Science.gov (United States)

    Halenár, Igor; Juhásová, Bohuslava; Juhás, Martin

    2016-12-01

    This article first describes the current state of the problem in the area of communication in modern factories. Next in the article is given a summary of the requirements that must be implemented for the possibility of establishing a compatible and safe communication system. In the final part of the article is given a proposal of communication model suitable for the implementation.

  13. Neutrino Oscillation Results from NOvA

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    NOvA is an accelerator long-baseline neutrino oscillation experiment optimised to measure electron neutrino appearance in a high-purity beam of muon neutrinos from Fermilab. The exciting discovery of the theta13 neutrino mixing angle in 2012 has opened a door to making multiple new measurements of neutrinos. These include leptonic CP violation, the neutrino mass ordering and the octant of theta23. NOvA with its 810km baseline and higher energy beam has about triple the matter effect of T2K which opens a new window on the neutrino mass ordering. With about 20% of our design beam exposure and significant analysis improvements we have recently released updated results. I will present both our disappearance and appearance measurements.

  14. Neutrino mass and the solar neutrino problem

    International Nuclear Information System (INIS)

    Wolfenstein, L.

    1987-01-01

    Theoretical ideas about neutrino mass based on grand-unified theories are reviewed. These give the see-saw formula in which neutrino mass is inversely proportional to a large mass scale M. For M between 10/sup 11/ and 10/sup 15/ Gev the study of solar neutrinos appears to be the best probe of neutrino masses and mixings

  15. Neutrino clouds

    International Nuclear Information System (INIS)

    Stephenson Jr, G.J.; McKellar, B.H.J.

    1997-01-01

    We consider the possibility that neutrinos are coupled very weakly to an extremely light scalar boson. We first analyze the simple problem of one generation of neutrino and show that, for ranges of parameters that are allowed by existing data, such a system can have serious consequences for the evolution of stars and could impact precision laboratory measurements. We discuss the extension to more generations and show that the general conclusion remains viable. Finally, we note that, should such a scalar field be present, experiments give information about effective masses, not the masses that arise in unified field theories. (authors). 23 refs., 9 figs

  16. Neutrino clouds

    Energy Technology Data Exchange (ETDEWEB)

    Stephenson Jr, G.J. [New Mexico Univ., Albuquerque, NM (United States). Dept. of Physics and Astronomy; Goldman, T. [Los Alamos National Lab., NM (United States); McKellar, B.H.J. [Melbourne Univ., Parkville, VIC (Australia). School of Physics

    1997-06-01

    We consider the possibility that neutrinos are coupled very weakly to an extremely light scalar boson. We first analyze the simple problem of one generation of neutrino and show that, for ranges of parameters that are allowed by existing data, such a system can have serious consequences for the evolution of stars and could impact precision laboratory measurements. We discuss the extension to more generations and show that the general conclusion remains viable. Finally, we note that, should such a scalar field be present, experiments give information about effective masses, not the masses that arise in unified field theories. (authors). 23 refs., 9 figs.

  17. Neutrino Telescope

    International Nuclear Information System (INIS)

    Coelin Baldo, Milla

    2009-01-01

    The present volume contains the proceedings of the 13. International Workshop on 'Neutrino Telescope', 17. of the series 'Un altro modo di guardare il cielo', held in Venice at the 'Istituto Veneto di Scienze, Lettere ed Arti' from March 10 to March 13, 2009. This series started in Venice 21 years ago, in 1988, motivated by the growing interest in the exciting field of the neutrino physics and astrophysics, with the aim to bring together experimentalists and theorists and encourage discussion on the most recent results and to chart the direction of future researchers.

  18. A Group-Based Mobile Application to Increase Adherence in Exercise and Nutrition Programs: A Factorial Design Feasibility Study

    Science.gov (United States)

    Venkatakrishnan, Anusha; Youngblood, Gregory Michael; Ram, Ashwin; Pirolli, Peter

    2016-01-01

    Background Novel methods of promoting self-monitoring and social support are needed to ensure long-term maintenance of behavior change. In this paper, we directly investigate the effects of group support in an exercise and nutrition program delivered by an mHealth application called Fittle. Objective Our first specific study aim was to explore whether social support improved adherence in wellness programs. Our second specific study aim was to assess whether media types (ePaper vs mobile) were associated with different levels of compliance and adherence to wellness programs. The third aim was to assess whether the use of an mHealth application led to positive changes to participants’ eating behavior, physical activity, and stress level, compared to traditional paper-based programs. Methods A 2 × 2 (eg, Media: Mobile vs ePaper × Group Type: Team vs Solo) factorial design feasibility study was conducted. A sample of 124 volunteers who were interested in improving eating behavior, increasing physical activity, or reducing stress participated in this study. The study duration was 8 weeks. All groups were self-directed with no ongoing human input from the research team. Results Participants in ePaper conditions had higher attrition rates compared to participants in Mobile conditions, χ3 2=9.96, P=.02 (N=124). Participants in Mobile conditions reported their compliance with a much higher frequency closer to the time of challenge activity completion (2-sample Kolmogorov-Smirnov test comparing distributions was highly significant—KS=0.33, PMobile conditions—χ1 2=25.25, Pmobile app allowed a more accurate method to report and track health behaviors over a longer period than traditional ePaper-based diaries or log books. There was a significant difference in the overall compliance score for Mobile-Solo (Mean [SD] 0.30 [0.39]) and Mobile-Team (Mean [SD] 0.49 [0.35]) conditions (t 50.82=1.94, P=.05). This suggests that working in a team increased participants

  19. Application of general multilevel factorial design with formulation of fast disintegrating tablets containing croscaremellose sodium and Disintequick MCC-25.

    Science.gov (United States)

    Solaiman, Amanda; Suliman, Ammar Said; Shinde, Swapnil; Naz, Sidra; Elkordy, Amal Ali

    2016-03-30

    Despite the popularity of orally fast disintegrating tablets (FDTs), their formulation can sometimes be challenging, producing tablets with either poor mechanical properties or high disintegration times. The aim of this research was to enhance the properties of FDTs produced by direct compression to have both sufficient hardness to withstand manual handling, and rapid disintegration time. General multilevel factorial design was applied to optimise and evaluate main and interaction effects of independent variables (i) disintegrant concentration, (ii) % filler (Disintequick MCC-25) to mannitol on the responses hardness, tensile strength and disintegration time. In this experiment mannitol was used as a diluent, Disintequick MCC-25 (to best of our knowledge there is no publication available yet for its use with FDTs) was termed in this study as a filler and croscaremellose sodium was used as the superdisintegrant. Seven formulations were prepared following a progressive two-stage approach. Each stage involved the change in the ratio of excipients (Mannitol:Filler) (1:0), (1:0.25), (1:0.50), (1:1), (0.50:1), (0.25:1), (0:1) w/w and concentration of superdisintegrant (1%, 3%, 5%, 7%, 10% w/w). All FDTs were tested for different parameters such as diameter, hardness, tensile strength, thickness, friability and disintegration time. The results of multiple linear regression analysis show a good degree of correlation between experimental (R(2):0.84, 0.94, 0.91) and predicted response (R(2):0.83, 0.96, 0.95) for hardness, tensile strength and disintegration time respectively. The optimum formulations (regarding disintegration time with acceptable hardness and friability properties) consisted of: (i) 5% w/w disintegrant and 20% w/w filler to mannitol, showing a disintegration time of 30s, a hardness of 66.6N (6.8 kg/cm(2)) and friability of 2.2%; (ii) 7% or 10% w/w disintegrant with 33.33% w/w filler to mannitol, showing disintegration time of 84 s (for 7% disintegrant) and

  20. Design and Development of a Relative Humidity and Room Temperature Measurement System with On Line Data Logging Feature for Monitoring the Fermentation Room of Tea Factory

    Directory of Open Access Journals (Sweden)

    Utpal SARMA

    2011-12-01

    Full Text Available The design and development of a Relative Humidity (RH and Room Temperature (RT monitoring system with on line data logging feature for monitoring fermentation room of a tea factory is presented in this paper. A capacitive RH sensor with on chip signal conditioner is taken as RH sensor and a temperature to digital converter (TDC is used for ambient temperature monitoring. An 8051 core microcontroller is the heart of the whole system which reads the digital equivalent of RH data with the help of a 12-bit Analog to Digital (A/D converter and synchronize TDC to get the ambient temperature. The online data logging is achieved with the help of RS-232C communication. Field performance is also studied by installing it in the fermentation room of a tea factory.

  1. Neutrino mixing and future accelerator neutrino experiments

    International Nuclear Information System (INIS)

    Bilenky, S.M.

    1992-01-01

    No evidence for neutrino mixing has been obtained in experiments searching for oscillations with neutrinos from accelerators and reactors. The possible reason is that neutrino masses are too small to produce any sizable effects in the experiments with terrestrial neutrinos. We put forward here the point of view that the reason for that can be traced to the presence of a hierarchy of neutrino masses as well as strength of couplings between lepton families. (orig.)

  2. Design of a Communication Scheme in a Modern Factory in Accordance with the Standard of Industry 4.0

    Directory of Open Access Journals (Sweden)

    Halenár Igor

    2016-12-01

    Full Text Available This article first describes the current state of the problem in the area of communication in modern factories. Next in the article is given a summary of the requirements that must be implemented for the possibility of establishing a compatible and safe communication system. In the final part of the article is given a proposal of communication model suitable for the implementation.

  3. Neutrino horn

    CERN Multimedia

    1967-01-01

    View of the new neutrino horn installed in its blockhouse from the target end. Protons pass through the 2mm hole in the centre of the small fluorescent screen, hitting the target immediately behind it. The circular tubes carry pressurized cooling water.

  4. Neutrino Oscillations

    Indian Academy of Sciences (India)

    The 2015 Nobel Prize in Physics was awarded to two physicists-Takaaki Kajita and Arthur B McDonald, whose teams discoveredthat neutrinos, which come in three flavours, changefrom one flavour to another. This discovery is a major milestonein particle physics as it gives a clear evidence of physicsbeyond the Standard ...

  5. Solar Neutrinos

    Indian Academy of Sciences (India)

    7,81. The Chlorine experiment, located in the Homestake Gold Mine in Lead, South Dakota, was the first solar neutrino experiment to be set up. A tank of. 105 gallons of perchloroethylene in which the electron neu- trino reacts with chlorine to ...

  6. Feasibility of performing neutrino experiments at an intense source of strangeness

    International Nuclear Information System (INIS)

    Carlini, R.D.; Stephenson, G.J. Jr.

    1983-01-01

    Several very important low energy neutrino experiments have been identified and discussed by Kayser and Rosen in these proceedings. We address the possibility of performing some of these experiments in the environment of a kaon factory. To carry out specific analyses, we draw upon the design of existing BNL detectors, the design of experiments that are proposed for an 800 MeV proton driven facility at Los Alamos, and the use of the code NUBEAM developed at CERN. Since in most cases we have not optimized, this is a conservative estimate. We find that many of the desired experiments can be performed with facilities now under discussion

  7. Neutrino Interactions

    International Nuclear Information System (INIS)

    Kamyshkov, Yuri; Handler, Thomas

    2016-01-01

    The neutrino group of the University of Tennessee, Knoxville was involved from 05/01/2013 to 04/30/2015 in the neutrino physics research funded by DOE-HEP grant DE-SC0009861. Contributions were made to the Double Chooz nuclear reactor experiment in France where second detector was commissioned during this period and final series of measurements has been started. Although Double Chooz was smaller experimental effort than competitive Daya Bay and RENO experiments, its several advantages make it valuable for understanding of systematic errors in measurements of neutrino oscillations. Double Chooz was the first experiment among competing three that produced initial result for neutrino angle θ_1_3 measurement, giving other experiments the chance to improve measured value statistically. Graduate student Ben Rybolt defended his PhD thesis on the results of Double Chooz experiment in 2015. UT group has fulfilled all the construction and analysis commitments to Double Chooz experiment, and has withdrawn from the collaboration by the end of the mentioned period to start another experiment. Larger effort of UT neutrino group during this period was devoted to the participation in another DOE-HEP project - NOvA experiment. The 14,000-ton 'FAR' neutrino detector was commissioned in northern Minnesota in 2014 together with 300-ton 'NEAR' detector located at Fermilab. Following that, the physics measurement program has started when Fermilab accelerator complex produced the high-intensity neutrino beam propagating through Earth to detector in MInnessota. UT group contributed to NOvA detector construction and developments in several aspects. Our Research Associate Athanasios Hatzikoutelis was managing (Level 3 manager) the construction of the Detector Control System. This work was successfully accomplished in time with the commissioning of the detectors. Group was involved in the development of the on-line software and study of the signatures of the cosmic ray backgrounds

  8. Neutrino Interactions

    Energy Technology Data Exchange (ETDEWEB)

    Kamyshkov, Yuri [Univ. of Tennesse, Knoxville, TN (United States); Handler, Thomas [Univ. of Tennesse, Knoxville, TN (United States)

    2016-10-24

    The neutrino group of the University of Tennessee, Knoxville was involved from 05/01/2013 to 04/30/2015 in the neutrino physics research funded by DOE-HEP grant DE-SC0009861. Contributions were made to the Double Chooz nuclear reactor experiment in France where second detector was commissioned during this period and final series of measurements has been started. Although Double Chooz was smaller experimental effort than competitive Daya Bay and RENO experiments, its several advantages make it valuable for understanding of systematic errors in measurements of neutrino oscillations. Double Chooz was the first experiment among competing three that produced initial result for neutrino angle θ13 measurement, giving other experiments the chance to improve measured value statistically. Graduate student Ben Rybolt defended his PhD thesis on the results of Double Chooz experiment in 2015. UT group has fulfilled all the construction and analysis commitments to Double Chooz experiment, and has withdrawn from the collaboration by the end of the mentioned period to start another experiment. Larger effort of UT neutrino group during this period was devoted to the participation in another DOE-HEP project - NOvA experiment. The 14,000-ton "FAR" neutrino detector was commissioned in northern Minnesota in 2014 together with 300-ton "NEAR" detector located at Fermilab. Following that, the physics measurement program has started when Fermilab accelerator complex produced the high-intensity neutrino beam propagating through Earth to detector in MInnessota. UT group contributed to NOvA detector construction and developments in several aspects. Our Research Associate Athanasios Hatzikoutelis was managing (Level 3 manager) the construction of the Detector Control System. This work was successfully accomplished in time with the commissioning of the detectors. Group was involved in the development of the on-line software and study of the signatures of the cosmic ray backgrounds

  9. ANTARES: The first undersea neutrino telescope

    Science.gov (United States)

    Ageron, M.; Aguilar, J. A.; Al Samarai, I.; Albert, A.; Ameli, F.; André, M.; Anghinolfi, M.; Anton, G.; Anvar, S.; Ardid, M.; Arnaud, K.; Aslanides, E.; Assis Jesus, A. C.; Astraatmadja, T.; Aubert, J.-J.; Auer, R.; Barbarito, E.; Baret, B.; Basa, S.; Bazzotti, M.; Becherini, Y.; Beltramelli, J.; Bersani, A.; Bertin, V.; Beurthey, S.; Biagi, S.; Bigongiari, C.; Billault, M.; Blaes, R.; Bogazzi, C.; de Botton, N.; Bou-Cabo, M.; Boudahef, B.; Bouwhuis, M. C.; Brown, A. M.; Brunner, J.; Busto, J.; Caillat, L.; Calzas, A.; Camarena, F.; Capone, A.; Caponetto, L.; Cârloganu, C.; Carminati, G.; Carmona, E.; Carr, J.; Carton, P. H.; Cassano, B.; Castorina, E.; Cecchini, S.; Ceres, A.; Chaleil, Th.; Charvis, Ph.; Chauchot, P.; Chiarusi, T.; Circella, M.; Compère, C.; Coniglione, R.; Coppolani, X.; Cosquer, A.; Costantini, H.; Cottini, N.; Coyle, P.; Cuneo, S.; Curtil, C.; D'Amato, C.; Damy, G.; van Dantzig, R.; de Bonis, G.; Decock, G.; Decowski, M. P.; Dekeyser, I.; Delagnes, E.; Desages-Ardellier, F.; Deschamps, A.; Destelle, J.-J.; di Maria, F.; Dinkespiler, B.; Distefano, C.; Dominique, J.-L.; Donzaud, C.; Dornic, D.; Dorosti, Q.; Drogou, J.-F.; Drouhin, D.; Druillole, F.; Durand, D.; Durand, R.; Eberl, T.; Emanuele, U.; Engelen, J. J.; Ernenwein, J.-P.; Escoffier, S.; Falchini, E.; Favard, S.; Fehr, F.; Feinstein, F.; Ferri, M.; Ferry, S.; Fiorello, C.; Flaminio, V.; Folger, F.; Fritsch, U.; Fuda, J.-L.; Galatá, S.; Galeotti, S.; Gay, P.; Gensolen, F.; Giacomelli, G.; Gojak, C.; Gómez-González, J. P.; Goret, Ph.; Graf, K.; Guillard, G.; Halladjian, G.; Hallewell, G.; van Haren, H.; Hartmann, B.; Heijboer, A. J.; Heine, E.; Hello, Y.; Henry, S.; Hernández-Rey, J. J.; Herold, B.; Hößl, J.; Hogenbirk, J.; Hsu, C. C.; Hubbard, J. R.; Jaquet, M.; Jaspers, M.; de Jong, M.; Jourde, D.; Kadler, M.; Kalantar-Nayestanaki, N.; Kalekin, O.; Kappes, A.; Karg, T.; Karkar, S.; Karolak, M.; Katz, U.; Keller, P.; Kestener, P.; Kok, E.; Kok, H.; Kooijman, P.; Kopper, C.; Kouchner, A.; Kretschmer, W.; Kruijer, A.; Kuch, S.; Kulikovskiy, V.; Lachartre, D.; Lafoux, H.; Lagier, P.; Lahmann, R.; Lahonde-Hamdoun, C.; Lamare, P.; Lambard, G.; Languillat, J.-C.; Larosa, G.; Lavalle, J.; Le Guen, Y.; Le Provost, H.; Levansuu, A.; Lefèvre, D.; Legou, T.; Lelaizant, G.; Lévéque, C.; Lim, G.; Lo Presti, D.; Loehner, H.; Loucatos, S.; Louis, F.; Lucarelli, F.; Lyashuk, V.; Magnier, P.; Mangano, S.; Marcel, A.; Marcelin, M.; Margiotta, A.; Martinez-Mora, J. A.; Masullo, R.; Mazéas, F.; Mazure, A.; Meli, A.; Melissas, M.; Migneco, E.; Mongelli, M.; Montaruli, T.; Morganti, M.; Moscoso, L.; Motz, H.; Musumeci, M.; Naumann, C.; Naumann-Godo, M.; Neff, M.; Niess, V.; Nooren, G. J. L.; Oberski, J. E. J.; Olivetto, C.; Palanque-Delabrouille, N.; Palioselitis, D.; Papaleo, R.; Păvălaş, G. E.; Payet, K.; Payre, P.; Peek, H.; Petrovic, J.; Piattelli, P.; Picot-Clemente, N.; Picq, C.; Piret, Y.; Poinsignon, J.; Popa, V.; Pradier, T.; Presani, E.; Prono, G.; Racca, C.; Raia, G.; van Randwijk, J.; Real, D.; Reed, C.; Réthoré, F.; Rewiersma, P.; Riccobene, G.; Richardt, C.; Richter, R.; Ricol, J. S.; Rigaud, V.; Roca, V.; Roensch, K.; Rolin, J.-F.; Rostovtsev, A.; Rottura, A.; Roux, J.; Rujoiu, M.; Ruppi, M.; Russo, G. V.; Salesa, F.; Salomon, K.; Sapienza, P.; Schmitt, F.; Schöck, F.; Schuller, J.-P.; Schüssler, F.; Sciliberto, D.; Shanidze, R.; Shirokov, E.; Simeone, F.; Sottoriva, A.; Spies, A.; Spona, T.; Spurio, M.; Steijger, J. J. M.; Stolarczyk, Th.; Streeb, K.; Sulak, L.; Taiuti, M.; Tamburini, C.; Tao, C.; Tasca, L.; Terreni, G.; Tezier, D.; Toscano, S.; Urbano, F.; Valdy, P.; Vallage, B.; van Elewyck, V.; Vannoni, G.; Vecchi, M.; Venekamp, G.; Verlaat, B.; Vernin, P.; Virique, E.; de Vries, G.; van Wijk, R.; Wijnker, G.; Wobbe, G.; de Wolf, E.; Yakovenko, Y.; Yepes, H.; Zaborov, D.; Zaccone, H.; Zornoza, J. D.; Zúñiga, J.

    2011-11-01

    The ANTARES Neutrino Telescope was completed in May 2008 and is the first operational Neutrino Telescope in the Mediterranean Sea. The main purpose of the detector is to perform neutrino astronomy and the apparatus also offers facilities for marine and Earth sciences. This paper describes the design, the construction and the installation of the telescope in the deep sea, offshore from Toulon in France. An illustration of the detector performance is given.

  10. ANTARES: The first undersea neutrino telescope

    International Nuclear Information System (INIS)

    Ageron, M.; Aguilar, J.A.; Al Samarai, I.; Albert, A.; Ameli, F.; Andre, M.; Anghinolfi, M.; Anton, G.; Anvar, S.; Ardid, M.; Arnaud, K.; Aslanides, E.; Assis Jesus, A.C.; Astraatmadja, T.; Aubert, J.-J.; Auer, R.; Barbarito, E.; Baret, B.

    2011-01-01

    The ANTARES Neutrino Telescope was completed in May 2008 and is the first operational Neutrino Telescope in the Mediterranean Sea. The main purpose of the detector is to perform neutrino astronomy and the apparatus also offers facilities for marine and Earth sciences. This paper describes the design, the construction and the installation of the telescope in the deep sea, offshore from Toulon in France. An illustration of the detector performance is given.

  11. Statistical analysis of weld bead geometry in Ti6Al4V laser cladding. Comparison of central composite design and five step full factorial test plan

    Energy Technology Data Exchange (ETDEWEB)

    Marko, Angelina [Fraunhofer Institute for Production Systems and Design Technology IPK, Berlin (Germany); Graf, Benjamin; Rethmeier, Michael [Fraunhofer Institute for Production Systems and Design Technology IPK, Berlin (Germany). Dept. for Joining and Coating Technology

    2017-11-01

    The process of laser cladding has become more important during recent years because of its broad application for cladding, repair or additive manufacturing. In the field of mechanical engineering, one use is the repair of turbine blades. For high quality and reliability of the repaired components, it is necessary to adjust the weld bead geometry to the specific repair task. The bead geometry influences the metallurgical bonding and the degree of dilution as well as the formation of defects like pores or cracks. Therefore, it is important to know the effects of the different parameters on the welding bead. A valuable tool to meet this industrial challenge is the design of experiments (DoE). In this context, the user can choose between a huge number of test plans. Greater profit of information is expected by a larger test range. In order to confirm the acceptance, a five-step full factorial test plan is compared to a central composite design in this paper. Moreover, the limits of the experimental range are indicated and restrictions can be derived. As the results show, the essential effects are detected with a full factorial test plan as well as with a central composite design. Merely the effect strength could not always be specified unambiguously. On this account and in consideration of cost efficiency, the use of central compound design is recommended in industrial applications.

  12. Statistical analysis of weld bead geometry in Ti6Al4V laser cladding. Comparison of central composite design and five step full factorial test plan

    International Nuclear Information System (INIS)

    Marko, Angelina; Graf, Benjamin; Rethmeier, Michael

    2017-01-01

    The process of laser cladding has become more important during recent years because of its broad application for cladding, repair or additive manufacturing. In the field of mechanical engineering, one use is the repair of turbine blades. For high quality and reliability of the repaired components, it is necessary to adjust the weld bead geometry to the specific repair task. The bead geometry influences the metallurgical bonding and the degree of dilution as well as the formation of defects like pores or cracks. Therefore, it is important to know the effects of the different parameters on the welding bead. A valuable tool to meet this industrial challenge is the design of experiments (DoE). In this context, the user can choose between a huge number of test plans. Greater profit of information is expected by a larger test range. In order to confirm the acceptance, a five-step full factorial test plan is compared to a central composite design in this paper. Moreover, the limits of the experimental range are indicated and restrictions can be derived. As the results show, the essential effects are detected with a full factorial test plan as well as with a central composite design. Merely the effect strength could not always be specified unambiguously. On this account and in consideration of cost efficiency, the use of central compound design is recommended in industrial applications.

  13. Probing the Absolute Mass Scale of Neutrinos

    International Nuclear Information System (INIS)

    Formaggio, Joseph A.

    2011-01-01

    The experimental efforts of the Neutrino Physics Group at MIT center primarily around the exploration of neutrino mass and its significance within the context of nuclear physics, particle physics, and cosmology. The group has played a prominent role in the Sudbury Neutrino Observatory, a neutrino experiment dedicated to measure neutrino oscillations from 8B neutrinos created in the sun. The group is now focusing its efforts in the measurement of the neutrino mass directly via the use of tritium beta decay. The MIT group has primary responsibilities in the Karlsruhe Tritium Neutrino mass experiment, expected to begin data taking by 2013. Specifically, the MIT group is responsible for the design and development of the global Monte Carlo framework to be used by the KATRIN collaboration, as well as responsibilities directly associated with the construction of the focal plane detector. In addition, the MIT group is sponsoring a new research endeavor for neutrino mass measurements, known as Project 8, to push beyond the limitations of current neutrino mass experiments.

  14. Climatic and basin factors affecting the flood frequency curve: PART II – A full sensitivity analysis based on the continuous simulation approach combined with a factorial experimental design

    Directory of Open Access Journals (Sweden)

    M. Franchini

    2000-01-01

    Full Text Available The sensitivity analysis described in Hashemi et al. (2000 is based on one-at-a-time perturbations to the model parameters. This type of analysis cannot highlight the presence of parameter interactions which might indeed affect the characteristics of the flood frequency curve (ffc even more than the individual parameters. For this reason, the effects of the parameters of the rainfall, rainfall runoff models and of the potential evapotranspiration demand on the ffc are investigated here through an analysis of the results obtained from a factorial experimental design, where all the parameters are allowed to vary simultaneously. This latter, more complex, analysis confirms the results obtained in Hashemi et al. (2000 thus making the conclusions drawn there of wider validity and not related strictly to the reference set selected. However, it is shown that two-factor interactions are present not only between different pairs of parameters of an individual model, but also between pairs of parameters of different models, such as rainfall and rainfall-runoff models, thus demonstrating the complex interaction between climate and basin characteristics affecting the ffc and in particular its curvature. Furthermore, the wider range of climatic regime behaviour produced within the factorial experimental design shows that the probability distribution of soil moisture content at the storm arrival time is no longer sufficient to explain the link between the perturbations to the parameters and their effects on the ffc, as was suggested in Hashemi et al. (2000. Other factors have to be considered, such as the probability distribution of the soil moisture capacity, and the rainfall regime, expressed through the annual maximum rainfalls over different durations. Keywords: Monte Carlo simulation; factorial experimental design; analysis of variance (ANOVA

  15. Computer experimental analysis of the CHP performance of a 100 kW e SOFC Field Unit by a factorial design

    Science.gov (United States)

    Calì, M.; Santarelli, M. G. L.; Leone, P.

    Gas Turbine Technologies (GTT) and Politecnico di Torino, both located in Torino (Italy), have been involved in the design and installation of a SOFC laboratory in order to analyse the operation, in cogenerative configuration, of the CHP 100 kW e SOFC Field Unit, built by Siemens-Westinghouse Power Corporation (SWPC), which is at present (May 2005) starting its operation and which will supply electric and thermal power to the GTT factory. In order to take the better advantage from the analysis of the on-site operation, and especially to correctly design the scheduled experimental tests on the system, we developed a mathematical model and run a simulated experimental campaign, applying a rigorous statistical approach to the analysis of the results. The aim of this work is the computer experimental analysis, through a statistical methodology (2 k factorial experiments), of the CHP 100 performance. First, the mathematical model has been calibrated with the results acquired during the first CHP100 demonstration at EDB/ELSAM in Westerwoort. After, the simulated tests have been performed in the form of computer experimental session, and the measurement uncertainties have been simulated with perturbation imposed to the model independent variables. The statistical methodology used for the computer experimental analysis is the factorial design (Yates' Technique): using the ANOVA technique the effect of the main independent variables (air utilization factor U ox, fuel utilization factor U F, internal fuel and air preheating and anodic recycling flow rate) has been investigated in a rigorous manner. Analysis accounts for the effects of parameters on stack electric power, thermal recovered power, single cell voltage, cell operative temperature, consumed fuel flow and steam to carbon ratio. Each main effect and interaction effect of parameters is shown with particular attention on generated electric power and stack heat recovered.

  16. Neutrinos: Theory and Phenomenology

    Energy Technology Data Exchange (ETDEWEB)

    Parke, Stephen

    2013-10-22

    The theory and phenomenology of neutrinos will be addressed, especially that relating to the observation of neutrino flavor transformations. The current status and implications for future experiments will be discussed with special emphasis on the experiments that will determine the neutrino mass ordering, the dominant flavor content of the neutrino mass eigenstate with the smallest electron neutrino content and the size of CP violation in the neutrino sector. Beyond the neutrino Standard Model, the evidence for and a possible definitive experiment to confirm or refute the existence of light sterile neutrinos will be briefly discussed.

  17. Applying Bayesian neural networks to separate neutrino events from backgrounds in reactor neutrino experiments

    International Nuclear Information System (INIS)

    Xu, Y; Meng, Y X; Xu, W W

    2008-01-01

    A toy detector has been designed to simulate central detectors in reactor neutrino experiments in the paper. The samples of neutrino events and three major backgrounds from the Monte-Carlo simulation of the toy detector are generated in the signal region. The Bayesian Neural Networks (BNN) are applied to separate neutrino events from backgrounds in reactor neutrino experiments. As a result, the most neutrino events and uncorrelated background events in the signal region can be identified with BNN, and the part events each of the fast neutron and 8 He/ 9 Li backgrounds in the signal region can be identified with BNN. Then, the signal to noise ratio in the signal region is enhanced with BNN. The neutrino discrimination increases with the increase of the neutrino rate in the training sample. However, the background discriminations decrease with the decrease of the background rate in the training sample

  18. Daya bay reactor neutrino experiment

    International Nuclear Information System (INIS)

    Cao Jun

    2010-01-01

    Daya Bay Reactor Neutrino Experiment is a large international collaboration experiment under construction. The experiment aims to precisely determine the neutrino mixing angle θ 13 by detecting the neutrinos produced by the Daya Bay Nuclear Power Plant. θ 13 is one of two unknown fundamental parameters in neutrino mixing. Its magnitude is a roadmap of the future neutrino physics, and very likely related to the puzzle of missing antimatter in our universe. The precise measurement has very important physics significance. The detectors of Daya Bay is under construction now. The full operation is expected in 2011. Three years' data taking will reach the designed the precision, to determine sin 2 2θ 13 to better than 0.01. Daya Bay neutrino detector is an underground large nuclear detector of low background, low energy, and high precision. In this paper, the layout of the experiment, the design and fabrication progress of the detectors, and some highlighted nuclear detecting techniques developed in the detector R and D are introduced. (author)

  19. Supernova neutrinos

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    In the first part of his in-depth article on the 1987 supernova, David Schramm of the University of Chicago and the NASA/Fermilab Astrophysics Centre reviewed the background to supernovae, the composition of massive stars and the optical history of SN 1987A, and speculated on what the 1987 remnant might be. In such a Type II supernova, gravitational pressure crushes the atoms of the star's interior producing neutron matter, or even a black hole, and releasing an intense burst of neutrinos. 1987 was the first time that physicists were equipped (but not entirely ready!) to intercept these particles, and in the second part of his article, David Schramm covers the remarkable new insights from the science of supernova neutrino astronomy, born on 23 February 1987

  20. Study on uranium loss during 'Iron-Gypsum Cake' precipitation from acid leach liquor of Jaduguda ore using factorially designed experiments

    International Nuclear Information System (INIS)

    Das, Amrita; Yadav, Manoj; Chatterjee, Ankur; Singh, A.K.; Hubli, R.C.

    2012-01-01

    Acid leaching process for uranium recovery from ore often generates considerable amounts of impurities into the solution. It is a challenge to separate the non-valuable impurities as manageable and stable waste products for final disposal, without losing the valuable constituents. The main impurities that come with the leach liquor are iron and sulfate. Their removal is essential for meeting the iron requirement in leaching circuit and also for making the effluent suitable for recycle. Factorial design analysis was applied to study of process variables for precipitation of iron and sulphate from leach liquor with composition using CaO as precipitation reagent

  1. Design of the Fermilab neutrino horn train system referenced to radioactive maintenance

    International Nuclear Information System (INIS)

    Grimson, J.; Lindberg, J.; Simon, J.; Theriot, D.

    1975-01-01

    A high-energy physics device known as a Horn, which operates at 140,000 A and 8 kV, has unique problems in keeping it operationally serviced after being exposed to 300- to 400-GeV protons and 1 to 5 x 10 13 protons per pulse. A modular system consisting of two horns, one cooled by a pulsed water spray and the other by forced air cooling, along with their associated utilities and instrumentation, was designed for primary servicing using electric master-slave manipulators and TV viewing

  2. Men's Preferences for Physical Activity Interventions: An Exploratory Study Using a Factorial Survey Design Created With R Software.

    Science.gov (United States)

    Chatfield, Sheryl L; Gamble, Abigail; Hallam, Jeffrey S

    2018-03-01

    Effective exercise interventions are needed to improve quality of life and decrease the impact of chronic disease. Researchers suggest males have been underrepresented in exercise intervention studies, resulting in less understanding of their exercise practices. Findings from preference survey methods suggest reasonable association between preference and behavior. The purpose of the research described in this article was to use factorial survey, a preference method, to identify the characteristics of exercise interventions most likely to appeal to male participants, so preferences might be incorporated into future intervention research. The research was guided by the framework of Bandura's social cognitive theory, such that variations in individual, environmental, and behavioral factors were incorporated into vignettes. Participants included 53 adult male nonadministrative staff and contract employees at a public university in the Southeastern United States, who each scored 8 vignettes resulting in 423 observations. Multilevel models were used to assess the influence of the factors. Participants scored vignettes that included exercising with a single partner, playing basketball, and exercising in the evening higher than vignettes with other options. Qualitative analysis of an open response item identified additional alternatives in group size, participant desire for coaching support, and interest in programs that incorporate a range of activity alternatives. Findings from this research were consistent with elements of social cognitive theory as applied to health promotion. Factorial surveys potentially provide a resource effective means of identifying participants' preferences for use when planning interventions. The addition of a single qualitative item helped clarify and expand findings from statistical analysis.

  3. Development and Validation of HPLC-DAD and UHPLC-DAD Methods for the Simultaneous Determination of Guanylhydrazone Derivatives Employing a Factorial Design.

    Science.gov (United States)

    Azevedo de Brito, Wanessa; Gomes Dantas, Monique; Andrade Nogueira, Fernando Henrique; Ferreira da Silva-Júnior, Edeildo; Xavier de Araújo-Júnior, João; Aquino, Thiago Mendonça de; Adélia Nogueira Ribeiro, Êurica; da Silva Solon, Lilian Grace; Soares Aragão, Cícero Flávio; Barreto Gomes, Ana Paula

    2017-08-30

    Guanylhydrazones are molecules with great pharmacological potential in various therapeutic areas, including antitumoral activity. Factorial design is an excellent tool in the optimization of a chromatographic method, because it is possible quickly change factors such as temperature, mobile phase composition, mobile phase pH, column length, among others to establish the optimal conditions of analysis. The aim of the present work was to develop and validate a HPLC and UHPLC methods for the simultaneous determination of guanylhydrazones with anticancer activity employing experimental design. Precise, exact, linear and robust HPLC and UHPLC methods were developed and validated for the simultaneous quantification of the guanylhydrazones LQM10, LQM14, and LQM17. The UHPLC method was more economic, with a four times less solvent consumption, and 20 times less injection volume, what allowed better column performance. Comparing the empirical approach employed in the HPLC method development to the DoE approach employed in the UHPLC method development, we can conclude that the factorial design made the method development faster, more practical and rational. This resulted in methods that can be employed in the analysis, evaluation and quality control of these new synthetic guanylhydrazones.

  4. Tamarind seed gum-hydrolyzed polymethacrylamide-g-gellan beads for extended release of diclofenac sodium using 32 full factorial design.

    Science.gov (United States)

    Nandi, Gouranga; Nandi, Amit Kumar; Khan, Najim Sarif; Pal, Souvik; Dey, Sibasish

    2018-07-15

    Development of tamarind seed gum (TSG)-hydrolyzed polymethacrylamide-g-gellan (h-Pmaa-g-GG) composite beads for extended release of diclofenac sodium using 3 2 full factorial design is the main purpose of this study. The ratio of h-Pmaa-g-GG and TSG and concentration of cross-linker CaCl 2 were taken as independent factors with three different levels of each. Effects of polymer ratio and CaCl 2 on drug entrapment efficiency (DEE), drug release, bead size and swelling were investigated. Responses such as DEE and different drug release parameters were statistically analyzed by 3 2 full factorial design using Design-Expert software and finally the formulation factors were optimized to obtain USP-reference release profile. Drug release rate was found to decrease with decrease in the ratio of h-Pmaa-g-GG:TSG and increase in the concentration of Ca 2+ ions in cross-linking medium. The optimized formulation showed DEE of 93.25% and an extended drug release profile over a period of 10h with f 2 =80.13. Kinetic modeling unveiled case-I-Fickian diffusion based drug release mechanism. Copyright © 2018 Elsevier B.V. All rights reserved.

  5. Evidence for neutrino oscillations in the Sudbury Neutrino Observatory

    International Nuclear Information System (INIS)

    Marino, Alysia Diane

    2004-01-01

    The Sudbury Neutrino Observatory (SNO) is a large-volume heavy water Cerenkov detector designed to resolve the solar neutrino problem. SNO observes charged-current interactions with electron neutrinos, neutral-current interactions with all active neutrinos, and elastic-scattering interactions primarily with electron neutrinos with some sensitivity to other flavors. This dissertation presents an analysis of the solar neutrino flux observed in SNO in the second phase of operation, while ∼2 tonnes of salt (NaCl) were dissolved in the heavy water. The dataset here represents 391 live days of data. Only the events above a visible energy threshold of 5.5 MeV and inside a fiducial volume within 550 cm of the center of the detector are studied. The neutrino flux observed via the charged-current interaction is [1.71 ± 0.065(stat.)± 0.068 0.065 (sys.)±0.02(theor.)] x 10 6 cm -2 s -1 , via the elastic-scattering interaction is [2.21±0.22(stat.)± 0.12 0.11 (sys.)±0.01(theor.)] x 10 6 cm -2 s -1 , and via the neutral-current interaction is [5.05±0.23(stat.)± 0.37 0.31 (sys.)±0.06(theor.)] x 10 6 cm -2 s -1 . The electron-only flux seen via the charged-current interaction is more than 7σ below the total active flux seen via the neutral-current interaction, providing strong evidence that neutrinos are undergoing flavor transformation as they travel from the core of the Sun to the Earth. The most likely origin of the flavor transformation is matter-induced flavor oscillation

  6. Evidence for neutrino oscillations in the Sudbury Neutrino Observatory

    Energy Technology Data Exchange (ETDEWEB)

    Marino, Alysia Diane [Univ. of California, Berkeley, CA (United States)

    2004-01-01

    The Sudbury Neutrino Observatory (SNO) is a large-volume heavy water Cerenkov detector designed to resolve the solar neutrino problem. SNO observes charged-current interactions with electron neutrinos, neutral-current interactions with all active neutrinos, and elastic-scattering interactions primarily with electron neutrinos with some sensitivity to other flavors. This dissertation presents an analysis of the solar neutrino flux observed in SNO in the second phase of operation, while ~2 tonnes of salt (NaCl) were dissolved in the heavy water. The dataset here represents 391 live days of data. Only the events above a visible energy threshold of 5.5 MeV and inside a fiducial volume within 550 cm of the center of the detector are studied. The neutrino flux observed via the charged-current interaction is [1.71 ± 0.065(stat.)±$0.065\\atop{0.068}$(sys.)±0.02(theor.)] x 106cm-2s-1, via the elastic-scattering interaction is [2.21±0.22(stat.)±$0.12\\atop{0.11}$(sys.)±0.01(theor.)] x 106cm-2s-1, and via the neutral-current interaction is [5.05±0.23(stat.)±$0.31\\atop{0.37}$(sys.)±0.06(theor.)] x 106cm-2s-1. The electron-only flux seen via the charged-current interaction is more than 7σ below the total active flux seen via the neutral-current interaction, providing strong evidence that neutrinos are undergoing flavor transformation as they travel from the core of the Sun to the Earth. The most likely origin of the flavor transformation is matter-induced flavor oscillation.

  7. The Intermediate Neutrino Program

    CERN Document Server

    Adams, C.; Ankowski, A.M.; Asaadi, J.A.; Ashenfelter, J.; Axani, S.N.; Babu, K.; Backhouse, C.; Band, H.R.; Barbeau, P.S.; Barros, N.; Bernstein, A.; Betancourt, M.; Bishai, M.; Blucher, E.; Bouffard, J.; Bowden, N.; Brice, S.; Bryan, C.; Camilleri, L.; Cao, J.; Carlson, J.; Carr, R.E.; Chatterjee, A.; Chen, M.; Chen, S.; Chiu, M.; Church, E.D.; Collar, J.I.; Collin, G.; Conrad, J.M.; Convery, M.R.; Cooper, R.L.; Cowen, D.; Davoudiasl, H.; de Gouvea, A.; Dean, D.J.; Deichert, G.; Descamps, F.; DeYoung, T.; Diwan, M.V.; Djurcic, Z.; Dolinski, M.J.; Dolph, J.; Donnelly, B.; Dwyer, D.A.; Dytman, S.; Efremenko, Y.; Everett, L.L.; Fava, A.; Figueroa-Feliciano, E.; Fleming, B.; Friedland, A.; Fujikawa, B.K.; Gaisser, T.K.; Galeazzi, M.; Galehouse, D.C.; Galindo-Uribarri, A.; Garvey, G.T.; Gautam, S.; Gilje, K.E.; Gonzalez-Garcia, M.; Goodman, M.C.; Gordon, H.; Gramellini, E.; Green, M.P.; Guglielmi, A.; Hackenburg, R.W.; Hackenburg, A.; Halzen, F.; Han, K.; Hans, S.; Harris, D.; Heeger, K.M.; Herman, M.; Hill, R.; Holin, A.; Huber, P.; Jaffe, D.E.; Johnson, R.A.; Joshi, J.; Karagiorgi, G.; Kaufman, L.J.; Kayser, B.; Kettell, S.H.; Kirby, B.J.; Klein, J.R.; Kolomensky, Yu. G.; Kriske, R.M.; Lane, C.E.; Langford, T.J.; Lankford, A.; Lau, K.; Learned, J.G.; Ling, J.; Link, J.M.; Lissauer, D.; Littenberg, L.; Littlejohn, B.R.; Lockwitz, S.; Lokajicek, M.; Louis, W.C.; Luk, K.; Lykken, J.; Marciano, W.J.; Maricic, J.; Markoff, D.M.; Martinez Caicedo, D.A.; Mauger, C.; Mavrokoridis, K.; McCluskey, E.; McKeen, D.; McKeown, R.; Mills, G.; Mocioiu, I.; Monreal, B.; Mooney, M.R.; Morfin, J.G.; Mumm, P.; Napolitano, J.; Neilson, R.; Nelson, J.K.; Nessi, M.; Norcini, D.; Nova, F.; Nygren, D.R.; Orebi Gann, G.D.; Palamara, O.; Parsa, Z.; Patterson, R.; Paul, P.; Pocar, A.; Qian, X.; Raaf, J.L.; Rameika, R.; Ranucci, G.; Ray, H.; Reyna, D.; Rich, G.C.; Rodrigues, P.; Romero, E.Romero; Rosero, R.; Rountree, S.D.; Rybolt, B.; Sanchez, M.C.; Santucci, G.; Schmitz, D.; Scholberg, K.; Seckel, D.; Shaevitz, M.; Shrock, R.; Smy, M.B.; Soderberg, M.; Sonzogni, A.; Sousa, A.B.; Spitz, J.; St. John, J.M.; Stewart, J.; Strait, J.B.; Sullivan, G.; Svoboda, R.; Szelc, A.M.; Tayloe, R.; Thomson, M.A.; Toups, M.; Vacheret, A.; Vagins, M.; Van de Water, R.G.; Vogelaar, R.B.; Weber, M.; Weng, W.; Wetstein, M.; White, C.; White, B.R.; Whitehead, L.; Whittington, D.W.; Wilking, M.J.; Wilson, R.J.; Wilson, P.; Winklehner, D.; Winn, D.R.; Worcester, E.; Yang, L.; Yeh, M.; Yokley, Z.W.; Yoo, J.; Yu, B.; Yu, J.; Zhang, C.

    2015-01-01

    The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program (WINP) at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summ...

  8. The Intermediate Neutrino Program

    Energy Technology Data Exchange (ETDEWEB)

    Adams, C.; et al.

    2015-03-23

    The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program (WINP) at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop.

  9. The Intermediate Neutrino Program

    Energy Technology Data Exchange (ETDEWEB)

    Adams, C. [Yale Univ., New Haven, CT (United States); Alonso, J. R. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Ankowski, A. M. [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Asaadi, J. A. [Syracuse Univ., NY (United States); Ashenfelter, J. [Yale Univ., New Haven, CT (United States); Axani, S. N. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Babu, K [Oklahoma State Univ., Stillwater, OK (United States); Backhouse, C. [California Inst. of Technology (CalTech), Pasadena, CA (United States); Band, H. R. [Yale Univ., New Haven, CT (United States); Barbeau, P. S. [Duke Univ., Durham, NC (United States); Barros, N. [Univ. of Pennsylvania, Philadelphia, PA (United States); Bernstein, A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Betancourt, M. [Illinois Inst. of Technology, Chicago, IL (United States); Bishai, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Blucher, E. [Univ. of Chicago, IL (United States); Bouffard, J. [State Univ. of New York (SUNY), Albany, NY (United States); Bowden, N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Brice, S. [Illinois Inst. of Technology, Chicago, IL (United States); Bryan, C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Camilleri, L. [Columbia Univ., New York, NY (United States); Cao, J. [Inst. of High Energy Physics, Beijing (China); Carlson, J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Carr, R. E. [Columbia Univ., New York, NY (United States); Chatterjee, A. [Univ. of Texas, Arlington, TX (United States); Chen, M. [Univ. of California, Irvine, CA (United States); Chen, S. [Tsinghua Univ., Beijing (China); Chiu, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Church, E. D. [Illinois Inst. of Technology, Chicago, IL (United States); Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Collar, J. I. [Univ. of Chicago, IL (United States); Collin, G. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Conrad, J. M. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Convery, M. R. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Cooper, R. L. [Indiana Univ., Bloomington, IN (United States); Cowen, D. [Pennsylvania State Univ., University Park, PA (United States); Davoudiasl, H. [Brookhaven National Lab. (BNL), Upton, NY (United States); Gouvea, A. D. [Northwestern Univ., Evanston, IL (United States); Dean, D. J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Deichert, G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Descamps, F. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); DeYoung, T. [Michigan State Univ., East Lansing, MI (United States); Diwan, M. V. [Brookhaven National Lab. (BNL), Upton, NY (United States); Djurcic, Z. [Argonne National Lab. (ANL), Argonne, IL (United States); Dolinski, M. J. [Drexel Univ., Philadelphia, PA (United States); Dolph, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Donnelly, B. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Dwyer, D. A. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Dytman, S. [Univ. of Pittsburgh, PA (United States); Efremenko, Y. [Univ. of Tennessee, Knoxville, TN (United States); Everett, L. L. [Univ. of Wisconsin, Madison, WI (United States); Fava, A. [University of Padua, Padova (Italy); Figueroa-Feliciano, E. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Fleming, B. [Yale Univ., New Haven, CT (United States); Friedland, A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Fujikawa, B. K. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Gaisser, T. K. [Univ. of Delaware, Newark, DE (United States); Galeazzi, M. [Univ. of Miami, FL (United States); Galehouse, DC [Univ. of Akron, OH (United States); Galindo-Uribarri, A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Garvey, G. T. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Gautam, S. [Tribhuvan Univ., Kirtipur (Nepal); Gilje, K. E. [Illinois Inst. of Technology, Chicago, IL (United States); Gonzalez-Garcia, M. [Stony Brook Univ., NY (United States); Goodman, M. C. [Argonne National Lab. (ANL), Argonne, IL (United States); Gordon, H. [Brookhaven National Lab. (BNL), Upton, NY (United States); Gramellini, E. [Yale Univ., New Haven, CT (United States); Green, M. P. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Guglielmi, A. [University of Padua, Padova (Italy); Hackenburg, R. W. [Brookhaven National Lab. (BNL), Upton, NY (United States); Hackenburg, A. [Yale Univ., New Haven, CT (United States); Halzen, F. [Univ. of Wisconsin, Madison, WI (United States); Han, K. [Yale Univ., New Haven, CT (United States); Hans, S. [Brookhaven National Lab. (BNL), Upton, NY (United States); Harris, D. [Illinois Inst. of Technology, Chicago, IL (United States); Heeger, K. M. [Yale Univ., New Haven, CT (United States); Herman, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Hill, R. [Univ. of Chicago, IL (United States); Holin, A. [Univ. College London, Bloomsbury (United Kingdom); Huber, P. [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Jaffe, D. E. [Brookhaven National Lab. (BNL), Upton, NY (United States); Johnson, R. A. [Univ. of Cincinnati, OH (United States); Joshi, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Karagiorgi, G. [Univ. of Manchester (United Kingdom); Kaufman, L. J. [Indiana Univ., Bloomington, IN (United States); Kayser, B. [Illinois Inst. of Technology, Chicago, IL (United States); Kettell, S. H. [Brookhaven National Lab. (BNL), Upton, NY (United States); Kirby, B. J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Klein, J. R. [Univ. of Texas, Arlington, TX (United States); Kolomensky, Y. G. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of California, Berkeley, CA (United States); Kriske, R. M. [Univ. of Minnesota, Minneapolis, MN (United States); Lane, C. E. [Drexel Univ., Philadelphia, PA (United States); Langford, T. J. [Yale Univ., New Haven, CT (United States); Lankford, A. [Univ. of California, Irvine, CA (United States); Lau, K. [Univ. of Houston, TX (United States); Learned, J. G. [Univ. of Hawaii, Honolulu, HI (United States); Ling, J. [Univ. of Illinois, Urbana-Champaign, IL (United States); Link, J. M. [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Lissauer, D. [Brookhaven National Lab. (BNL), Upton, NY (United States); Littenberg, L. [Brookhaven National Lab. (BNL), Upton, NY (United States); Littlejohn, B. R. [Illinois Inst. of Technology, Chicago, IL (United States); Lockwitz, S. [Illinois Inst. of Technology, Chicago, IL (United States); Lokajicek, M. [Inst. of Physics of the Academy of Sciences of Czech Republic, Prague (Czech Republic); Louis, W. C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Luk, K. [Univ. of California, Berkeley, CA (United States); Lykken, J. [Illinois Inst. of Technology, Chicago, IL (United States); Marciano, W. J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Maricic, J. [Univ. of Hawaii, Honolulu, HI (United States); Markoff, D. M. [North Carolina Central Univ., Durham, NC (United States); Caicedo, D. A. M. [Illinois Inst. of Technology, Chicago, IL (United States); Mauger, C. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Mavrokoridis, K. [Univ. of Liverpool (United Kingdom); McCluskey, E. [Illinois Inst. of Technology, Chicago, IL (United States); McKeen, D. [Univ. of Washington, Seattle, WA (United States); McKeown, R. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Mills, G. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Mocioiu, I. [Pennsylvania State Univ., University Park, PA (United States); Monreal, B. [Univ. of California, Santa Barbara, CA (United States); Mooney, M. R. [Brookhaven National Lab. (BNL), Upton, NY (United States); Morfin, J. G. [Illinois Inst. of Technology, Chicago, IL (United States); Mumm, P. [National Inst. of Standards and Technology (NIST), Boulder, CO (United States); Napolitano, J. [Temple Univ., Philadelphia, PA (United States); Neilson, R. [Drexel Univ., Philadelphia, PA (United States); Nelson, J. K. [College of William and Mary, Williamsburg, VA (United States); Nessi, M. [European Organization for Nuclear Research (CERN), Geneva (Switzerland); Norcini, D. [Yale Univ., New Haven, CT (United States); Nova, F. [Univ. of Texas, Austin, TX (United States); Nygren, D. R. [Univ. of Texas, Arlington, TX (United States); Gann, GDO [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of California, Berkeley, CA (United States); Palamara, O. [Illinois Inst. of Technology, Chicago, IL (United States); Parsa, Z. [Brookhaven National Lab. (BNL), Upton, NY (United States); Patterson, R. [California Inst. of Technology (CalTech), Pasadena, CA (United States); Paul, P. [Stony Brook Univ., NY (United States); Pocar, A. [Univ. of Massachusetts, Amherst, MA (United States); Qian, X. [Brookhaven National Lab. (BNL), Upton, NY (United States); Raaf, J. L. [Illinois Inst. of Technology, Chicago, IL (United States); Rameika, R. [Illinois Inst. of Technology, Chicago, IL (United States); Ranucci, G. [National Inst. of Nuclear Physics, Milano (Italy); Ray, H. [Univ. of Florida, Gainesville, FL (United States); Reyna, D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Rich, G. C. [Triangle Universities Nuclear Lab., Durham, NC (United States); Rodrigues, P. [Univ. of Rochester, NY (United States); Romero, E. R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States); Rosero, R. [Brookhaven National Lab. (BNL), Upton, NY (United States); Rountree, S. D. [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Rybolt, B. [Univ. of Tennessee, Knoxville, TN (United States); Sanchez, M. C. [Iowa State Univ., Ames, IA (United States); Santucci, G. [Stony Brook Univ., NY (United States); Schmitz, D. [Univ. of Chicago, IL (United States); Scholberg, K. [Duke Univ., Durham, NC (United States); Seckel, D. [Univ. of Delaware, Newark, DE (United States); Shaevitz, M. [Columbia Univ., New York, NY (United States); Shrock, R. [Stony Brook Univ., NY (United States); Smy, M. B. [Univ. of California, Irvine, CA (United States); Soderberg, M. [Syracuse Univ., NY (United States); Sonzogni, A. [Brookhaven National Lab. (BNL), Upton, NY (United States); Sousa, A. B. [Univ. of Cincinnati, OH (United States); Spitz, J. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); John, J. M. S. [Univ. of Cincinnati, OH (United States); Stewart, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Strait, J. B. [Illinois Inst. of Technology, Chicago, IL (United States); Sullivan, G. [Univ. of Maryland, College Park, MD (United States); Svoboda, R. [Univ. of California, Davis, CA (United States); Szelc, A. M. [Yale Univ., New Haven, CT (United States); Tayloe, R. [Indiana Univ., Bloomington, IN (United States); Thomson, M. A. [Univ. of Cambridge (United Kingdom); Toups, M. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Vacheret, A. [Univ. of Oxford (United Kingdom); Vagins, M. [Univ. of California, Irvine, CA (United States); Water, R. G. V. D. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Vogelaar, R. B. [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Weber, M. [Bern (Switzerland); Weng, W. [Brookhaven National Lab. (BNL), Upton, NY (United States); Wetstein, M. [Univ. of Chicago, IL (United States); White, C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); White, B. R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Whitehead, L. [Univ. of Houston, TX (United States); Whittington, D. W. [Indiana Univ., Bloomington, IN (United States); Wilking, M. J. [Stony Brook Univ., NY (United States); Wilson, R. J. [Colorado State Univ., Fort Collins, CO (United States); Wilson, P. [Illinois Inst. of Technology, Chicago, IL (United States); Winklehner, D. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Winn, D. R. [Fairfield Univ., CT (United States); Worcester, E. [Brookhaven National Lab. (BNL), Upton, NY (United States); Yang, L. [Univ. of Illinois, Urbana-Champaign, IL (United States); Yeh, M [Brookhaven National Lab. (BNL), Upton, NY (United States); Yokley, Z. W. [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Yoo, J. [Illinois Inst. of Technology, Chicago, IL (United States); Yu, B. [Brookhaven National Lab. (BNL), Upton, NY (United States); Yu, J. [Univ. of Texas, Arlington, TX (United States); Zhang, C. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2017-04-03

    The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program (WINP) at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop.

  10. Search for sterile neutrinos at RENO

    Science.gov (United States)

    Yeo, In Sung; RENO Collaboration

    2017-09-01

    The RENO experiment was designed to measure a neutrino mixing angle, θ13, by detecting electron antineutrinos emitted from the Hanbit nuclear reactors in Korea, and succeeded to measure θ13 from the disappearance mode in three neutrino frame. We investigate the possibility of sterile neutrinos existence at RENO experiment and compare data with Monte Carlo generated in four neutrino frame. In this talk, we present some recent results using chi-square analysis method. The probability deficit curve as a function of an effective baseline and the excluded contour plot in sin2(2 θ14) - Δ(m41)2 space will be shown.

  11. Neutrino problems proliferate (Neutrino 94 conference report)

    International Nuclear Information System (INIS)

    Gordon, Fraser

    1994-01-01

    The enigma of the neutrino continues. More than sixty years after its hesitant prediction by Pauli and forty years after its discovery by Reines and Cowan, the neutrino still refuses to give up all its secrets. The longer we travel down the neutrino road and the more we find out about these particles, the more problems we uncover en route. The present state of the neutrino mystery was highlighted at the Neutrino 94 meeting in Eilat, Israel, from 29 May to 3 June. It was a distinguished meeting, with the first morning including one session chaired by neutrino co-discoverer Fred Reines, and an introductory talk by muon-neutrino co-discoverer Leon Lederman. One figurehead neutrino personality conspicuously absent this time was Bruno Pontecorvo, who died last year and had attended the previous conference in the series, in Grenada, Spain, in 1992

  12. Neutrino problems proliferate (Neutrino 94 conference report)

    Energy Technology Data Exchange (ETDEWEB)

    Gordon, Fraser

    1994-09-15

    The enigma of the neutrino continues. More than sixty years after its hesitant prediction by Pauli and forty years after its discovery by Reines and Cowan, the neutrino still refuses to give up all its secrets. The longer we travel down the neutrino road and the more we find out about these particles, the more problems we uncover en route. The present state of the neutrino mystery was highlighted at the Neutrino 94 meeting in Eilat, Israel, from 29 May to 3 June. It was a distinguished meeting, with the first morning including one session chaired by neutrino co-discoverer Fred Reines, and an introductory talk by muon-neutrino co-discoverer Leon Lederman. One figurehead neutrino personality conspicuously absent this time was Bruno Pontecorvo, who died last year and had attended the previous conference in the series, in Grenada, Spain, in 1992.

  13. ANTARES: An Undersea Neutrino telescope

    CERN Multimedia

    2002-01-01

    The ANTARES (Astronomy with a Neutrino Telescope and ${Abyss}$ environmental RESearch) deep-sea neutrino telescope is designed to search for neutrinos of astrophysical origin. Neutrinos are unique probes of the high energy universe; being neutral they are not deflected by magnetic fields and interacting weakly they can readily escape from the densest regions of the universe. Potential sources of neutrino are galactic (e.g supernova remnants, micro-quasars) and extra-galactic (e.g active galactic nuclei, gamma-ray bursters). Annihilation of dark matter particles in the Sun or Galactic Centre is another well motivated potential source of extra terrestrial neutrinos. The ANTARES detector is located 40 km off the coast of Toulon (France) at a depth of 2475m in the Mediterranean Sea. Being located in the Northern hemisphere it studies the Southern sky and in particular has the Galactic Centre in its field of view. Since 2006, the detector has operated continuously in a partial configuration. The detector was compl...

  14. AutoPyFactory: A Scalable Flexible Pilot Factory Implementation

    International Nuclear Information System (INIS)

    Caballero, J; Hover, J; Love, P; Stewart, G A

    2012-01-01

    The ATLAS experiment at the CERN LHC is one of the largest users of grid computing infrastructure, which is a central part of the experiment's computing operations. Considerable efforts have been made to use grid technology in the most efficient and effective way, including the use of a pilot job based workload management framework. In this model the experiment submits ‘pilot’ jobs to sites without payload. When these jobs begin to run they contact a central service to pick-up a real payload to execute. The first generation of pilot factories were usually specific to a single Virtual Organization (VO), and were bound to the particular architecture of that VO's distributed processing. A second generation provides factories which are more flexible, not tied to any particular VO, and provide new and improved features such as monitoring, logging, profiling, etc. In this paper we describe this key part of the ATLAS pilot architecture, a second generation pilot factory, AutoPyFactory. AutoPyFactory has a modular design and is highly configurable. It is able to send different types of pilots to sites and exploit different submission mechanisms and queue characteristics. It is tightly integrated with the PanDA job submission framework, coupling pilot flow to the amount of work the site has to run. It gathers information from many sources in order to correctly configure itself for a site and its decision logic can easily be updated. Integrated into AutoPyFactory is a flexible system for delivering both generic and specific job wrappers which can perform many useful actions before starting to run end-user scientific applications, e.g., validation of the middleware, node profiling and diagnostics, and monitoring. AutoPyFactory also has a robust monitoring system that has been invaluable in establishing a reliable pilot factory service for ATLAS.

  15. The Use of a Fractional Factorial Design to Determine the Factors That Impact 1,3-Propanediol Production from Glycerol by Halanaerobium hydrogeniformans

    Directory of Open Access Journals (Sweden)

    Shivani Kalia

    2016-08-01

    Full Text Available In recent years, biodiesel, a substitute for fossil fuels, has led to the excessive production of crude glycerol. The resulting crude glycerol can possess a high concentration of salts and an alkaline pH. Moreover, current crude glycerol purification methods are expensive, rendering this former commodity a waste product. However, Halanaerobium hydrogeniformans, a haloalkaliphilic bacterium, possesses the metabolic capability to convert glycerol into 1,3-propanediol, a valuable commodity compound, without the need for salt dilution or adjusting pH when grown on this waste. Experiments were performed with different combinations of 24 medium components to determine their impact on the production of 1,3-propanediol by using a fractional factorial design. Tested medium components were selected based on data from the organism’s genome. Analysis of HPLC data revealed enhanced production of 1,3-propanediol with additional glycerol, pH, vitamin B12, ammonium ions, sodium sulfide, cysteine, iron, and cobalt. However, other selected components; nitrate ions, phosphate ions, sulfate ions, sodium:potassium ratio, chloride, calcium, magnesium, silicon, manganese, zinc, borate, nickel, molybdenum, tungstate, copper and aluminum, did not enhance 1,3-propanediol production. The use of a fractional factorial design enabled the quick and efficient assessment of the impact of 24 different medium components on 1,3-propanediol production from glycerol from a haloalkaliphilic bacterium.

  16. The Use of a Fractional Factorial Design to Determine the Factors That Impact 1,3-Propanediol Production from Glycerol by Halanaerobium hydrogeniformans.

    Science.gov (United States)

    Kalia, Shivani; Trager, Jordan; Sitton, Oliver C; Mormile, Melanie R

    2016-08-20

    In recent years, biodiesel, a substitute for fossil fuels, has led to the excessive production of crude glycerol. The resulting crude glycerol can possess a high concentration of salts and an alkaline pH. Moreover, current crude glycerol purification methods are expensive, rendering this former commodity a waste product. However, Halanaerobium hydrogeniformans, a haloalkaliphilic bacterium, possesses the metabolic capability to convert glycerol into 1,3-propanediol, a valuable commodity compound, without the need for salt dilution or adjusting pH when grown on this waste. Experiments were performed with different combinations of 24 medium components to determine their impact on the production of 1,3-propanediol by using a fractional factorial design. Tested medium components were selected based on data from the organism's genome. Analysis of HPLC data revealed enhanced production of 1,3-propanediol with additional glycerol, pH, vitamin B12, ammonium ions, sodium sulfide, cysteine, iron, and cobalt. However, other selected components; nitrate ions, phosphate ions, sulfate ions, sodium:potassium ratio, chloride, calcium, magnesium, silicon, manganese, zinc, borate, nickel, molybdenum, tungstate, copper and aluminum, did not enhance 1,3-propanediol production. The use of a fractional factorial design enabled the quick and efficient assessment of the impact of 24 different medium components on 1,3-propanediol production from glycerol from a haloalkaliphilic bacterium.

  17. Optimization and influence of parameter affecting the compressive strength of geopolymer concrete containing recycled concrete aggregate: using full factorial design approach

    Science.gov (United States)

    Krishnan, Thulasirajan; Purushothaman, Revathi

    2017-07-01

    There are several parameters that influence the properties of geopolymer concrete, which contains recycled concrete aggregate as the coarse aggregate. In the present study, the vital parameters affecting the compressive strength of geopolymer concrete containing recycled concrete aggregate are analyzedby varying four parameters with two levels using full factorial design in statistical software Minitab® 17. The objective of the present work is to gain an idea on the optimization, main parameter effects, their interactions and the predicted response of the model generated using factorial design. The parameters such as molarity of sodium hydroxide (8M and 12M), curing time (6hrs and 24 hrs), curing temperature (60°C and 90°C) and percentage of recycled concrete aggregate (0% and 100%) are considered. The results show that the curing time, molarity of sodium hydroxide and curing temperature were the orderly significant parameters and the percentage of Recycled concrete aggregate (RCA) was statistically insignificant in the production of geopolymer concrete. Thus, it may be noticeable that the RCA content had negligible effect on the compressive strength of geopolymer concrete. The expected responses from the generated model showed a satisfactory and rational agreement to the experimental data with the R2 value of 97.70%. Thus, geopolymer concrete comprising recycled concrete aggregate can solve the major social and environmental concerns such as the depletion of the naturally available aggregate sources and disposal of construction and demolition waste into the landfill.

  18. Usage of a statistical method of designing factorial experiments in the mechanical activation of a complex CuPbZn sulphide concentrate

    Directory of Open Access Journals (Sweden)

    BalហPeter

    2003-09-01

    Full Text Available Mechanical activation belongs to innovative procedures which intensify technological processes by creating new surfaces and making a defective structure of solid phase. Mechanical impact on the solid phase is a suitable procedure to ensure the mobility of its structure elements and to accumulate the mechanical energy that is later used in the processes of leaching.The aim of this study was to realize the mechanical activation of a complex CuPbZn sulphide concentrate (Slovak deposit in an attritor by using of statistical methods for the design of factorial experiments and to determine the conditions for preparing the optimum mechanically activated sample of studied concentrate.The following parameters of the attritor were studied as variables:the weight of sample/steel balls (degree of mill filling, the number of revolutions of the milling shaft and the time of mechanical activation. Interpretation of the chosen variables inducing the mechanical activation of the complex CuPbZn concentrate was also carried out by using statistical methods of factorial design experiments. The presented linear model (23 factorial experiment does not support directly the optimum search, therefore this model was extended to the nonlinear model by the utilization of second order ortogonal polynom. This nonlinear model does not describe adequately the process of new surface formation by the mechanical activation of the studied concentrate. It would be necessary to extend the presented nonlinear model to the nonlinear model of the third order or choose another model. In regard to the economy with the aspect of minimal energy input consumption, the sample with the value of 524 kWht-1 and with the maximum value of specific surface area 8.59 m2g-1 (as a response of the factorial experiment was chosen as the optimum mechanically activated sample of the studied concentrate. The optimum mechanically activated sample of the complex CuPbZn sulphide concentrate was prepared

  19. Neutrino 2004: Collection of Presentations

    International Nuclear Information System (INIS)

    2004-01-01

    The scientific program covers the latest developments in neutrino physics, astrophysics and related topics through a set of invited talks and 2 poster sessions. The following issues are addressed: - solar neutrinos, - atmospheric neutrinos, - short and long baseline experiments, - neutrino oscillations, - double beta decay, - direct neutrino mass limits, - theory for neutrino masses, neutrino telescopes and ultra-high energy neutrinos, - dark matter searches, - neutrino in astrophysics and cosmology, and - future projects beams and experiments

  20. Neutrino 2004: Collection of Presentations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    The scientific program covers the latest developments in neutrino physics, astrophysics and related topics through a set of invited talks and 2 poster sessions. The following issues are addressed: - solar neutrinos, - atmospheric neutrinos, - short and long baseline experiments, - neutrino oscillations, - double beta decay, - direct neutrino mass limits, - theory for neutrino masses, neutrino telescopes and ultra-high energy neutrinos, - dark matter searches, - neutrino in astrophysics and cosmology, and - future projects beams and experiments.

  1. ABSOLUTE NEUTRINO MASSES

    DEFF Research Database (Denmark)

    Schechter, J.; Shahid, M. N.

    2012-01-01

    We discuss the possibility of using experiments timing the propagation of neutrino beams over large distances to help determine the absolute masses of the three neutrinos.......We discuss the possibility of using experiments timing the propagation of neutrino beams over large distances to help determine the absolute masses of the three neutrinos....

  2. Working Group Report: Neutrinos

    Energy Technology Data Exchange (ETDEWEB)

    de Gouvea, A.; Pitts, K.; Scholberg, K.; Zeller, G. P. [et al.

    2013-10-16

    This document represents the response of the Intensity Frontier Neutrino Working Group to the Snowmass charge. We summarize the current status of neutrino physics and identify many exciting future opportunities for studying the properties of neutrinos and for addressing important physics and astrophysics questions with neutrinos.

  3. Underground neutrino astronomy

    International Nuclear Information System (INIS)

    Schramm, D.N.

    1983-02-01

    A review is made of possible astronomical neutrino sources detectable with underground facilities. Comments are made about solar neutrinos and gravitational-collapse neutrinos, and particular emphasis is placed on ultra-high-energy astronomical neutrino sources. An appendix mentions the exotic possibility of monopolonium

  4. Neutrino astroparticle physics at Boulby Mine

    CERN Document Server

    Lüscher, R; Bewick, A; Cartwright, S L; Kudryavtsev, V A; Lightfoot, P K; Liubarsky, I; Marshall, R; Roberts, J W; Smith, N J T; Smith, P F; Spooner, N J C; Yeoman, L M

    2002-01-01

    Thanks to new funding, the Boulby Mine Underground Laboratories are undergoing a significant expansion. These improvements have been designed primarily to meet the requirements of the Dark Matter programme, but future plans for the facility also include the possible installation of neutrino detectors. In this contribution, we describe the new facility and review the Boulby neutrino astrophysics programme.

  5. Neutrino astroparticle physics at Boulby Mine

    International Nuclear Information System (INIS)

    Luscher, R.; Alner, G.J.; Bewick, A.; Cartwright, S.L.; Kudryavtsev, V.A.; Lightfoot, P.K.; Liubarsky, I.; Marshall, R.; Roberts, J.W.; Smith, N.J.T.; Smith, P.F.; Spooner, N.J.C.; Yeoman, L.M.

    2002-01-01

    Thanks to new funding, the Boulby Mine Underground Laboratories are undergoing a significant expansion. These improvements have been designed primarily to meet the requirements of the Dark Matter programme, but future plans for the facility also include the possible installation of neutrino detectors. In this contribution, we describe the new facility and review the Boulby neutrino astrophysics programme

  6. Introduction to massive neutrinos

    International Nuclear Information System (INIS)

    Kayser, B.

    1984-01-01

    We discuss the theoretical ideas which make it natural to expect that neutrinos do indeed have mass. Then we focus on the physical consequences of neutrino mass, including neutrino oscillation and other phenomena whose observation would be very interesting, and would serve to demonstrate that neutrinos are indeed massive. We comment on the legitimacy of comparing results from different types of experiments. Finally, we consider the question of whether neutrinos are their own antiparticles. We explain what this question means, discuss the nature of a neutrino which is its own antiparticles, and consider how one might determine experimentally whether neutrinos are their own antiparticles or not

  7. Neutrinos in Nuclear Physics

    Energy Technology Data Exchange (ETDEWEB)

    McKeown, Bob [bmck@jlab.org

    2015-06-01

    Since the discovery of nuclear beta decay, nuclear physicists have studied the weak interaction and the nature of neutrinos. Many recent and current experiments have been focused on the elucidation of neutrino oscillations and neutrino mass. The quest for the absolute value of neutrino mass continues with higher precision studies of the tritium beta decay spectrum near the endpoint. Neutrino oscillations are studied through measurements of reactor neutrinos as a function of baseline and energy. And experiments searching for neutrinoless double beta decay seek to discover violation of lepton number and establish the Majorana nature of neutrino masses.

  8. Neutrinos and Einstein

    CERN Document Server

    Suzuki, Yoichiro

    2005-01-01

    A tiny neutrino mass is a clue to the physics beyond the standard model of elementary particle physics. The primary cosmic rays, mostly protons, are created and accelerated to the relativistic energy in supernova remnants. They traverse the universe and reach the earth. The incoming primary cosmic rays interact with the earth's atmosphere to produce secondary particles, which subsequently decay into neutrinos, called atmospheric neutrinos. The atmospheric neutrinos have shown the evidence of the finite neutrino masses through the phenomena called neutrino oscillations. Neutrinos are detected by large detectors underground like, for example, Super-Kamiokande, SNO and KamLAND. Those detectors use large photomultiplier tubes, which make use of the photo-electric effect to convert photons created by the interaction of neutrinos to electrons to form electric pulses. Neutrinos are therefore created and detected by "Einstein" and have step forward beyond the current physics. Neutrinos may also carry a hit to the ori...

  9. 50 years of neutrinos

    CERN Document Server

    Goldhaber, M

    1980-01-01

    On December 4 1930, Wolfgang Pauli addressed an "open letter" to Lise Meitner and others attending a physics meeting, suggesting the neutrino as a way out of the difficulties confronted in beta rays research, especially by the existence of a continuous beta spectrum. He proposed a new particle later called the neutrino. The prehistory leading up to Pauli's letter will be reviewed, as well as the later discovery of the electron-neutrino followed by the muon-neutrino. There are now believed to be three different types of neutrino and their anti-particles. Neutrinos have a spin 1/2; but only one spin component has been found in nature: neutrinos go forward as "left-handed" screws and anti-neutrinos as "right-handed" ones. A question still not convincingly resolved today is wether neutrinos have a mass different from zero and, if they do, what consequences this would have for the behaviour of neutrinos and for cosmology.

  10. The solar neutrinos epopee

    CERN Document Server

    Lasserre, T

    2003-01-01

    The 2002 year has been fruitful for the neutrino physics. First, the Sudbury Neutrino Observatory (SNO) experiment has shown that the electron neutrinos nu sub e emitted by the sun are converted into muon neutrinos (nu submu) and tau neutrinos (nu subtau), thus closing the 30 years old problem of solar neutrinos deficit. This discovery validates the model of nuclear energy production inside the sun but it shakes the theory describing the weak interactions between the fundamental constituents of matter. This theory considers the neutrinos (and the photons) as massless particles, while the taste conversion phenomenon necessarily implies that neutrinos have a mass. In October 2000, the Universe exploration by the cosmic neutrinos is jointly recognized by R. Davis (USA) and M. Koshiba (Japan) who received the Nobel price of physics. Finally, in December 2000, the KamLAND experiment quantitatively demonstrated the neutrinos metamorphosis by detecting a deficit in the flux of electron antineutrinos coming from the ...

  11. Neutrino physics in heaven

    International Nuclear Information System (INIS)

    Raffelt, G.

    2005-01-01

    After a brief overview of the usual topics that connect astrophysics and cosmology with neutrino physics I will focus on two main themes. First, what can we learn from the neutrino signal of a future galactic supernova, in particular about the neutrino mass ordering. Second, what can we learn about neutrino properties from cosmological observables, notably about the neutrino absolute mass scale from cosmological large-scale structure observables. (author)

  12. Two lectures on neutrinos

    International Nuclear Information System (INIS)

    Ramond, P.

    1992-01-01

    These notes are based on two lectures delivered at the School. A general description of neutrinos is presented, first in purely kinematic terms, then in the context of the Standard Model, focusing on the role of the global lepton numbers. Standard Model extensions with massive neutrinos are cataloged. Several popular mass matrices for neutrinos, and their consequences are presented. They proceed to give an extended discussion of neutrino oscillations in matter, and apply the results to the solar neutrinos

  13. Workshop: Neutrino telescopes

    International Nuclear Information System (INIS)

    Anon.

    1990-01-01

    Despite being the most elusive of the known particles, neutrinos provide vital new physics insights. Most neutrino knowledge so far has come from studies using beams from reactors and accelerators, but in recent years important new contributions have resulted from investigation of natural neutrinos from cosmic rays, nearby stars (the sun), or distant sources, such as the 1987 supernova. The supernova observations marked the start of a new era in neutrino astronomy, but neutrino telescopes were anyway assured of an important ongoing role

  14. Workshop: Neutrino telescopes

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1990-05-15

    Despite being the most elusive of the known particles, neutrinos provide vital new physics insights. Most neutrino knowledge so far has come from studies using beams from reactors and accelerators, but in recent years important new contributions have resulted from investigation of natural neutrinos from cosmic rays, nearby stars (the sun), or distant sources, such as the 1987 supernova. The supernova observations marked the start of a new era in neutrino astronomy, but neutrino telescopes were anyway assured of an important ongoing role.

  15. Collective neutrino oscillations and neutrino wave packets

    Energy Technology Data Exchange (ETDEWEB)

    Akhmedov, Evgeny; Lindner, Manfred [Max-Planck-Institut für Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Kopp, Joachim, E-mail: akhmedov@mpi-hd.mpg.de, E-mail: jkopp@uni-mainz.de, E-mail: lindner@mpi-hd.mpg.de [PRISMA Cluster of Excellence and Mainz Institute for Theoretical Physics, Johannes Gutenberg University, 55099 Mainz (Germany)

    2017-09-01

    Effects of decoherence by wave packet separation on collective neutrino oscillations in dense neutrino gases are considered. We estimate the length of the wave packets of neutrinos produced in core collapse supernovae and the expected neutrino coherence length, and then proceed to consider the decoherence effects within the density matrix formalism of neutrino flavour transitions. First, we demonstrate that for neutrino oscillations in vacuum the decoherence effects are described by a damping term in the equation of motion of the density matrix of a neutrino as a whole (as contrasted to that of the fixed-momentum components of the neutrino density matrix). Next, we consider neutrino oscillations in ordinary matter and dense neutrino backgrounds, both in the adiabatic and non-adiabatic regimes. In the latter case we study two specific models of adiabaticity violation—one with short-term and another with extended non-adiabaticity. It is demonstrated that, while in the adiabatic case a damping term is present in the equation of motion of the neutrino density matrix (just like in the vacuum oscillation case), no such term in general appears in the non-adiabatic regime.

  16. Extrinsic CPT violation in neutrino oscillations in matter

    International Nuclear Information System (INIS)

    Jacobson, Magnus; Ohlsson, Tommy

    2004-01-01

    We investigate matter-induced (or extrinsic) CPT violation effects in neutrino oscillations in matter. Especially, we present approximate analytical formulas for the CPT-violating probability differences for three flavor neutrino oscillations in matter with an arbitrary matter density profile. Note that we assume that the CPT invariance theorem holds, which means that the CPT violation effects arise entirely because of the presence of matter. As special cases of matter density profiles, we consider constant and step-function matter density profiles, which are relevant for neutrino oscillation physics in accelerator and reactor long baseline experiments as well as neutrino factories. Finally, the implications of extrinsic CPT violation on neutrino oscillations in matter for several past, present, and future long baseline experiments are estimated

  17. European Strategy for Accelerator-Based Neutrino Physics

    CERN Document Server

    Bertolucci, Sergio; Cervera, Anselmo; Donini, Andrea; Dracos, Marcos; Duchesneau, Dominique; Dufour, Fanny; Edgecock, Rob; Efthymiopoulos, Ilias; Gschwendtner, Edda; Kudenko, Yury; Long, Ken; Maalampi, Jukka; Mezzetto, Mauro; Pascoli, Silvia; Palladino, Vittorio; Rondio, Ewa; Rubbia, Andre; Rubbia, Carlo; Stahl, Achim; Stanco, Luca; Thomas, Jenny; Wark, David; Wildner, Elena; Zito, Marco

    2012-01-01

    Massive neutrinos reveal physics beyond the Standard Model, which could have deep consequences for our understanding of the Universe. Their study should therefore receive the highest level of priority in the European Strategy. The discovery and study of leptonic CP violation and precision studies of the transitions between neutrino flavours require high intensity, high precision, long baseline accelerator neutrino experiments. The community of European neutrino physicists involved in oscillation experiments is strong enough to support a major neutrino long baseline project in Europe, and has an ambitious, competitive and coherent vision to propose. Following the 2006 European Strategy for Particle Physics (ESPP) recommendations, two complementary design studies have been carried out: LAGUNA/LBNO, focused on deep underground detector sites, and EUROnu, focused on high intensity neutrino facilities. LAGUNA LBNO recommends, as first step, a conventional neutrino beam CN2PY from a CERN SPS North Area Neutrino Fac...

  18. Solar Neutrinos

    Directory of Open Access Journals (Sweden)

    V. Antonelli

    2013-01-01

    relevant indications on the fundamental interactions among particles. After reviewing the striking results of the last two decades, which were determinant to solve the long standing solar neutrino puzzle and refine the Standard Solar Model, we focus our attention on the more recent results in this field and on the experiments presently running or planned for the near future. The main focus at the moment is to improve the knowledge of the mass and mixing pattern and especially to study in detail the lowest energy part of the spectrum, which represents most of the solar neutrino spectrum but is still a partially unexplored realm. We discuss this research project and the way in which present and future experiments could contribute to make the theoretical framework more complete and stable, understanding the origin of some “anomalies” that seem to emerge from the data and contributing to answer some present questions, like the exact mechanism of the vacuum to matter transition and the solution of the so-called solar metallicity problem.

  19. Neutrino physics with SHIP

    CERN Document Server

    van Herwijnen, Eric

    2016-01-01

    SHIP is a new general purpose fixed target facility, whose Technical Proposal has been recently reviewed by the CERN SPS Committee. It recommended that the experiment proceed further to a Comprehensive Design phase. In its initial phase, the 400 GeV proton beam extracted from the SPS will be dumped on a heavy target with the aim of integrating 2×1020 POT (Protons On Target) in 5 years. A dedicated detector, based on a long vacuum tank followed by a spectrometer and particle identification detectors, will allow probing a variety of models with light long-lived exotic particles and masses below O(10) GeV/c 2 . The main focus will be the physics of the so-called Hidden Portals. The sensitivity to Heavy Neutrinos will allow to probe for the first time the mass range between the kaon and the charm meson mass, and a range of couplings for which Baryogenesis and active neutrino masses could also be explained. Another dedicated detector will allow the study of neutrino cross-sections and angular distributions. ντ ...

  20. Polymeric nanoparticles loaded with the 3,5,3´-triiodothyroacetic acid (Triac, a thyroid hormone: factorial design, characterization, and release kinetics

    Directory of Open Access Journals (Sweden)

    dos Santos KC

    2012-07-01

    Full Text Available Karen C dos Santos,1 Maria Fatima GF da Silva,1 Edenir R Pereira-Filho,1 Joao B Fernandes,1 Igor Polikarpov,2 Moacir R Forim11Department of Chemistry, Federal University of Sao Carlos, Sao Carlos, 2Physics Institute of Sao Carlos, University of Sao Paulo, Sao Carlos, Sao Paulo, BrazilAbstract: This present investigation deals with the development and optimization of polymeric nanoparticle systems loaded with 3,5,3´-triiodothyroacetic acid (Triac. A 211–6 fractional factorial design and another 22 factorial design were used to study the contrasts on particle size distribution, morphology, surface charge, drug content, entrapment efficiency, and in vitro drug release profiles. The independent variables were the concentration of Triac, type and quantity of both polymer and oil, quantity of Span™ 60 and Tween® 80, volume of solvent and water, and velocity of both magnetic stirring and the transfer of the organic phase into the aqueous solution. The results of optimized formulations showed a narrow size distribution with a polydispersity index lower than 0.200. The particle sizes were on average 159.6 nm and 285.6 nm for nanospheres and nanocapsules, respectively. The zeta potential was higher than 20 mV (in module and the entrapment efficiency was nearly 100%. A high-performance liquid chromatography method was developed, validated, and efficiently applied to Triac quantification in colloidal suspension. The main independent variables were the type and quantity of the polymer and oil. In vitro drug release profile depicted several features to sustain Triac release. Different formulations showed various release rates indicating an interaction between Triac and other formulation compounds such as polymer and/or oil quantity. Two different models were identified (biexponential and monoexponential that allowed the control of both the release rate and Triac concentration. Thus, the prepared nanoparticles described here may be of clinical importance

  1. The physics of neutrinos

    CERN Document Server

    Barger, Vernon D; Whisnant, Kerry

    2012-01-01

    The physics of neutrinos- uncharged elementary particles that are key to helping us better understand the nature of our universe - is one of the most exciting frontiers of modern science. This book provides a comprehensive overview of neutrino physics today and explores promising new avenues of inquiry that could lead to future breakthroughs. The Physics of Neutrinos begins with a concise history of the field and a tutorial on the fundamental properties of neutrinos, and goes on to discuss how the three neutrino types interchange identities as they propagate from their sources to detectors. The book shows how studies of neutrinos produced by such phenomena as cosmic rays in the atmosphere and nuclear reactions in the solar interior provide striking evidence that neutrinos have mass, and it traces our astounding progress in deciphering the baffling experimental findings involving neutrinos. The discovery of neutrino mass offers the first indication of a new kind of physics that goes beyond the Standard Model ...

  2. Neutrino GDR meeting

    International Nuclear Information System (INIS)

    Aguilar-Saavedra, J.A.; Camilleri, L.; Mention, G.; VanElewyck, V.; Verderi, M.; Blondel, A.; Augier, C.; Bellefon, A. de; Coc, A.; Duchesneau, D.; Favier, J.; Lesgourgues, J.; Payet, J.

    2006-01-01

    The purpose of the neutrino GDR (research program coordination) is to federate the activities of French research teams devoted to studying the neutrino. The presentations have been organized on 2 days. A review of the present status of the theoretical and experimental knowledge on neutrinos on a worldwide basis has been made on the first day while the second day has been dedicated to reporting the activities of the 5 following working groups: 1) determination of neutrino parameters, 2) physics beyond the standard model, 3) neutrinos in the universe, 4) neutrino detection, and 5) common tools. During the first day the American neutrino research program has been presented through the description of the 2 neutrino detection systems: Nova and Minor. The following neutrino experiments involving nuclear reactors: Chooz (France), Daya-bay (China), Reno (Korea) and Angra (Brazil) have also been reviewed. This document is made up of the slides of the presentations

  3. Molybdenum solar neutrino experiment

    International Nuclear Information System (INIS)

    Wolfsberg, K.; Cowan, G.A.; Bryant, E.A.

    1984-01-01

    The goal of the molybdenum solar neutrino experiment is to deduce the 8 B solar neutrino flux, averaged over the past several million years, from the concentration of 98 Tc in a deeply buried molybdenum deposit. The experiment is important to an understanding of stellar processes because it will shed light on the reason for the discrepancy between theory and observation of the chlorine solar neutrino experiment. Possible reasons for the discrepancy may lie in the properties of neutrinos (neutrino oscillations or massive neutrinos) or in deficiencies of the standard solar model. The chlorine experiment only measures the 8 B neutrino flux in current times and does not address possible temporal variations in the interior of the sun, which are also not considered in the standard model. In the molybdenum experiment, we plan to measure 98 Tc (4.2 Myr), also produced by 8 B neutrinos, and possibly 97 Tc (2.6 Myr), produced by lower energy neutrinos

  4. Neutrino properties and fundamental symmetries

    International Nuclear Information System (INIS)

    Bowles, T.J.

    1996-01-01

    This is the final report of a three-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). There are two components to this work. The first is a development of a new detection scheme for neutrinos. The observed deficit of neutrinos from the Sun may be due to either a lack of understanding of physical processes in the Sun or may be due to neutrinos oscillating from one type to another during their transit from the Sun to the Earth. The Sudbury Neutrino Observatory (SNO) is designed to use a water Cerenkov detector employing one thousand tonnes of heavy water to resolve this question. The ability to distinguish muon and tau neutrinos from electron neutrinos is crucial in order to carry out a model-independent test of neutrino oscillations. We describe a developmental exploration of a novel technique to do this using 3 He proportional counters. Such a method offers considerable advantages over the initially proposed method of using Cerenkov light from capture on NaCl in the SNO. The second component of this work is an exploration of optimal detector geometry for a time-reversal invariance experiment. The question of why time moves only in the forward direction is one of the most puzzling problems in modern physics. We know from particle physics measurements of the decay of kaons that there is a charge-parity symmetry that is violated in nature, implying time-reversal invariance violation. Yet, we do not understand the origin of the violation of this symmetry. To promote such an understanding, we are developing concepts and prototype apparatus for a new, highly sensitive technique to search for time-reversal-invariance violation in the beta decay of the free neutron. The optimized detector geometry is seven times more sensitive than that in previous experiments. 15 refs

  5. Study of castor oil polyurethane - poly(methyl methacrylate semi-interpenetrating polymer network (SIPN reaction parameters using a 2³ factorial experimental design

    Directory of Open Access Journals (Sweden)

    Fernanda Oliveira Vieira da Cunha

    2004-12-01

    Full Text Available In this work was employed a 2³ factorial experiment design to evaluate the castor oil polyurethane-poly(methyl methacrylate semi-IPN synthesis. The reaction parameters used as independent variables were NCO/OH molar ratio, polyurethane polymerization time and methyl methacrylate (MMA content. The semi-IPNs were cured over 28 h using two thermal treatments. The polymers were characterized by infrared and Raman spectroscopy, thermal analysis and swelling profiles in n-hexane. The glass transition temperature (Tg and the swelling were more affect by the NCO/OH molar ratio variation. The semi-IPNs showed Tg from - 27 to - 6 °C and the swelling range was from 3 to 22%, according to the crosslink density. The IPN mechanical properties were dependent on the cure temperature and MMA content in it. Lower elastic modulus values were observed in IPNs cured at room temperature.

  6. Wear Analysis of a Ti-5Al-3V-2.5Fe Alloy Using a Factorial Design Approach and Fractal Geometry

    Directory of Open Access Journals (Sweden)

    A. W. El-Morsy

    2018-02-01

    Full Text Available This paper describes the application of the full factorial experimental design technique to confirm the significance of the factors affecting the wear behavior of a recycled Ti-5Al-3V-2.5Fe alloy with a minimum number of experiments. The fractal theory has been used to describe the worn surface state and to investigate the relationship between the fractal dimensions and the surface morphology. The experiments of the sliding wear have been performed under stresses in the range of 1-5 MPa and within sliding velocities range of 0.2–2.0 m/s. Morphology of the worn surfaces investigations has been undertaken using a scanning electron microscope. From the analysis of variance and the nonlinear regression model, the results show that the applied stress has a higher contribution to the wear rate than the sliding velocity.

  7. Process of chemical recycling of post-consumer PET using a factorial design; Processo de reciclagem quimica do PET pos-consumo empregando o planejamento fatorial

    Energy Technology Data Exchange (ETDEWEB)

    Lacerda, Carlos Eduardo de O.; Almeida, Yeda Medeiros B. de; Vinhas, Gloria M., E-mail: carlos.olacerda@hotmail.com [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil)

    2015-07-01

    The present study investigated important variables in the depolymerization reaction of post-consumer poly (ethylene terephthalate) - PET via alkaline hydrolysis. Through this reaction is obtained terephthalic acid (PTA), a monomer, which when purified, is used for the production of PET resin. The study was based on a 2{sup 2} factorial design in which the independent variables were the concentration of NaOH solution and the reaction time, and the dependent variable was the yield of PTA obtained. The experiments that generated the best results, 100 % of yield, were obtained with the higher values of the independent variables. Statistical analysis showed that the concentration of NaOH solution is the variable that most influences in the process. The PTA obtained was analyzed by NMR ¹H technique, confirming the strong resemblance to commercial PTA obtained by petrochemical way. (author)

  8. AutoPyFactory: A Scalable Flexible Pilot Factory Implementation

    CERN Document Server

    Caballero, J; The ATLAS collaboration; Love, P; Stewart, G

    2012-01-01

    The ATLAS experiment at the CERN LHC is one of the largest users of grid computing infrastructure, which is a central part of the experiment’s computing operations. Considerable efforts have been made to use grid technology in the most efficient and effective way, including the use of a pilot job based workload management framework. In this model the experiment submits ’pilot’ jobs to sites without payload. When these jobs begin to run they contact a central service to retrieve a real payload to execute. The first generation of pilot factories were usually specific to a single VO, and were bound to the particular architecture of that VO’s distributed processing. A second generation provides factories which are more flexible, not tied to any particular VO, and provide new or improved features such as monitoring, logging, profiling, etc. In this paper we describe this key part of the ATLAS pilot architecture, a second generation pilot factory, AutoPyFactory. AutoPyFactory has a modular design and is hig...

  9. Interim Design Report

    CERN Document Server

    Choubey, S.; Goswami, S.; Berg, J.S.; Fernow, R.; Gallardo, J.C.; Gupta, R.; Kirk, H.; Simos, N.; Souchlas, N.; Ellis, M.; Kyberd, P.; Benedetto, E.; Fernandez-Martinez, E.; Efthymiopoulos, I.; Garoby, R.; Gilardoni, S.; Martini, M.; Prior, G.; Ballett, P.; Pascoli, S.; Bross, A.; Geer, S.; Johnstone, C.; Kopp, J.; Mokhov, N.; Morfin, J.; Neuffer, D.; Parke, S.; Popovic, M.; Strait, J.; Striganov, S.; Blondel, A.; Dufour, F.; Laing, A.; Soler, F.J.P; Lindner, M.; Schwetz, T.; Alekou, A.; Apollonio, M.; Aslaninejad, M.; Bontoiu, C.; Dornan, P.; Eccleston, R.; Kurup, A.; Long, K.; Pasternak, J.; Pozimski, J.; Bogacz, A.; Morozov, V.; Roblin, Y.; Bhattacharya, S.; Majumdar, D.; Mori, Y.; Planche, T.; Zisman, M.; Cline, D.; Stratakis, D.; Ding, X.; Coloma, P.; Donini, A.; Gavela, B.; Lopez Pavon, J.; Maltoni, M.; Bromberg, C.; Bonesini, M.; Hart, T.; Kudenko, Y.; Mondal, N.; Antusch, S.; Blennow, M.; Ota, T.; Abrams, R.J.; Ankenbrandt, C.M.; Beard, K.B.; Cummings, M.A.C.; Flanagan, G.; Johnson, R.P.; Roberts, T.J.; Yoshikawa, C.Y.; Migliozzi, P.; Palladino, V.; de Gouvea, A.; Graves, V.B.; Kuno, Y.; Peltoniemi, J.; Blackmore, V.; Cobb, J.; Witte, H.; Mezzetto, M.; Rigolin, S.; McDonald, K.T.; Coney, L.; Hanson, G.; Snopok, P.; Tortora, L.; Andreopoulos, C.; Bennett, J.R.J.; Brooks, S.; Caretta, O.; Davenne, T.; Densham, C.; Edgecock, R.; Kelliher, D.; Loveridge, P.; McFarland, A.; Machida, S.; Prior, C.; Rees, G.; Rogers, C.; Thomason, J.W.G.; Booth, C.; Skoro, G.; Karadzhov, Y.; Matev, R.; Tsenov, R.; Samulyak, R.; Mishra, S.R.; Petti, R.; Dracos, M.; Yasuda, O.; Agarwalla, S.K.; Cervera-Villanueva, A.; Gomez-Cadenas, J.J.; Hernandez, P.; Li, T.; Martin-Albo, J.; Huber, P.; Back, J.; Barker, G.; Harrison, P.; Meloni, D.; Tang, J.; Winter, W.

    2011-01-01

    The International Design Study for the Neutrino Factory (the IDS-NF) was established by the community at the ninth "International Workshop on Neutrino Factories, super-beams, and beta- beams" which was held in Okayama in August 2007. The IDS-NF mandate is to deliver the Reference Design Report (RDR) for the facility on the timescale of 2012/13. In addition, the mandate for the study [3] requires an Interim Design Report to be delivered midway through the project as a step on the way to the RDR. This document, the IDR, has two functions: it marks the point in the IDS-NF at which the emphasis turns to the engineering studies required to deliver the RDR and it documents baseline concepts for the accelerator complex, the neutrino detectors, and the instrumentation systems. The IDS-NF is, in essence, a site-independent study. Example sites, CERN, FNAL, and RAL, have been identified to allow site-specific issues to be addressed in the cost analysis that will be presented in the RDR. The choice of example sites shou...

  10. Polymeric nanoparticles loaded with the 3,5,3'-triiodothyroacetic acid (Triac), a thyroid hormone: factorial design, characterization, and release kinetics.

    Science.gov (United States)

    Dos Santos, Karen C; da Silva, Maria Fatima Gf; Pereira-Filho, Edenir R; Fernandes, Joao B; Polikarpov, Igor; Forim, Moacir R

    2012-01-01

    This present investigation deals with the development and optimization of polymeric nanoparticle systems loaded with 3,5,3'-triiodothyroacetic acid (Triac). A 2(11-6) fractional factorial design and another 2(2) factorial design were used to study the contrasts on particle size distribution, morphology, surface charge, drug content, entrapment efficiency, and in vitro drug release profiles. The independent variables were the concentration of Triac, type and quantity of both polymer and oil, quantity of Span™ 60 and Tween® 80, volume of solvent and water, and velocity of both magnetic stirring and the transfer of the organic phase into the aqueous solution. The results of optimized formulations showed a narrow size distribution with a polydispersity index lower than 0.200. The particle sizes were on average 159.6 nm and 285.6 nm for nanospheres and nanocapsules, respectively. The zeta potential was higher than 20 mV (in module) and the entrapment efficiency was nearly 100%. A high-performance liquid chromatography method was developed, validated, and efficiently applied to Triac quantification in colloidal suspension. The main independent variables were the type and quantity of the polymer and oil. In vitro drug release profile depicted several features to sustain Triac release. Different formulations showed various release rates indicating an interaction between Triac and other formulation compounds such as polymer and/or oil quantity. Two different models were identified (biexponential and monoexponential) that allowed the control of both the release rate and Triac concentration. Thus, the prepared nanoparticles described here may be of clinical importance in delivering Triac for thyroid treatment.

  11. Quadrados latinos obtidos por meio de técnicas de confundimento em ensaios fatoriais Latin squares obtained by confounding techiniques in factorial designs

    Directory of Open Access Journals (Sweden)

    Maria Cristina Stolf Nogueira

    2000-09-01

    Full Text Available Os esquemas em quadrado latino tem se mostrado muito úteis na experimentação agronômica e zootécnica. O modo de obtenção dos quadrados latinos em geral segue regras algébricas de construção a partir de operações básicas sobre o conjunto de números inteiros positivos, mais especificamente, sobre as classes de resto módulo (m. Da mesma forma, considerando um ensaio instalado em esquema fatorial, ao se usar a técnica do confundimento, formam-se tantos quadrados latinos ortogonais quantos forem os níveis de tratamento. Tais esquemas conduzem a repetições ortogonais de quadrados latinos. Assim, o objetivo deste trabalho é abordar a aplicação desta técnica de modo a facilitar o planejamento. É apresentado um exemplo de um ensaio fatorial 3 x 3 x 3 sem repetições.Latin square designs have been very useful in agriculture and animal sciences. They are, in general, obtained following algebrical rules from basic operations for positive integers and the m-modular number system. In this way, from an experiment installed in a factorial scheme, it is possible to obtain as many latin squares as the levels of treatments, through the use of a confounding technique. These schemes lead to orthogonal replications of latin squares. The aim of this work was to evaluate this technique in order to facilitate plannings. An example of a 3 x 3 x 3 factorial design without replications is presented.

  12. Influence of the Formulation Parameters on the Particle Size and Encapsulation Efficiency of Resveratrol in PLA and PLA-PEG Blend Nanoparticles: A Factorial Design.

    Science.gov (United States)

    Lindner, Gabriela da Rocha; Dalmolin, Luciana Facco; Khalil, Najeh Maissar; Mainardes, Rubiana Mara

    2015-12-01

    Polymeric nanoparticles are colloidal systems that promote protection and modification of physicochemical characteristics of a drug and that also ensure controlled and extended drug release. This paper reports a 2(3) factorial design study to optimize poly(lactide) (PLA) and poly(lactide)-polyethylene glycol (PLA-PEG) blend nanoparticles containing resveratrol (RVT) for prolonged release. The independent variables analyzed were solvent composition, surfactant concentration and ratio of aqueous to organic phase (two levels each factor). Mean particle size and RVT encapsulation efficiency were set as the dependent variables. The selected optimized parameters were set as organic phase comprised of a mixture of dichloromethane and ethyl acetate, 1% of surfactant polyvinyl alcohol and a 3:1 ratio of aqueous to organic phase, for both PLA and PLA-PEG blend nanoparticles. This formulation originated nanoparticles with size of 228 ± 10 nm and 185 ± 70 nm and RVT encapsulation efficiency of 82 ± 10% and 76 ± 7% for PLA and PLA-PEG blend nanoparticles, respectively. The in vitro release study showed a biphasic pattern with prolonged RVT release and PEG did not influence the RVT release. The in vitro release data were in favor of Higuchi-diffusion kinetics for both nanoformulations and the Kossmeyer-Peppas coefficient indicated that anomalous transport was the main release mechanism of RVT. PLA and PLA-PEG blend nanoparticles produced with single emulsion-solvent evaporation technology were found to be a promising approach for the incorporation of RVT and promoted its controlled release. The factorial design is a tool of great value in choosing formulations with optimized parameters.

  13. The neutrino mirror

    International Nuclear Information System (INIS)

    Vannucci, F.

    2003-09-01

    The neutrino is not an elementary particle like others, it is the most stunning of all: the neutrino is undetectable by itself, we have only indirect evidences of its existence, but the neutrino is essential to explain the weak interaction, to understand why matter triumphed over anti-matter just after the Big-bang, or to solve the riddle of the hidden mass of the universe. This book is a popular work dedicated to the neutrino from its discovery in beta decays to the most recent theories such as neutrino oscillations, and via the worldwide experiments dedicated to the study of the neutrinos. (A.C.)

  14. Neutrino mass, a status report

    International Nuclear Information System (INIS)

    Robertson, R.G.H.

    1993-01-01

    Experimental approaches to neutrino mass include kinematic mass measurements, neutrino oscillation searches at rectors and accelerators, solar neutrinos, atmospheric neutrinos, and single and double beta decay. The solar neutrino results yield fairly strong and consistent indications that neutrino oscillations are occurring. Other evidence for new physics is less consistent and convincing

  15. Experimental Neutrino Physics: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Lane, Charles E.; Maricic, Jelena

    2012-09-05

    Experimental studies of neutrino properties, with particular emphasis on neutrino oscillation, mass and mixing parameters. This research was pursued by means of underground detectors for reactor anti-neutrinos, measuring the flux and energy spectra of the neutrinos. More recent investigations have been aimed and developing detector technologies for a long-baseline neutrino experiment (LBNE) using a neutrino beam from Fermilab.

  16. Planned e+e- factories

    International Nuclear Information System (INIS)

    Le Duff, J.

    1993-09-01

    Various Beauty and Tau-Charm factories and projects are reviewed. Different machines (TRISTAN II, PEP II, CESR-B, the Dubna project and the European project) are compared and their design and parameters are described. (K.A.) 34 refs., 2 figs., 2 tabs

  17. Evidence and Search for Sterile Neutrinos at Accelerators

    Directory of Open Access Journals (Sweden)

    W. C. Louis

    2013-01-01

    Full Text Available The LSND short-baseline neutrino experiment has published evidence for antineutrino oscillations at a mass scale of ~1 eV2. The MiniBooNE experiment, designed to test this evidence for oscillations at an order of magnitude higher neutrino energy and distance, observes excesses of events in both neutrino mode and antineutrino mode. While the MiniBooNE neutrino excess has a neutrino energy spectrum that is softer than expected from LSND, the MiniBooNE antineutrino excess is consistent with neutrino oscillations and with the LSND oscillation signal. When combined with oscillation measurements at the solar and atmospheric mass scales, assuming that the LSND and MiniBooNE signals are due to neutrino oscillations, these experiments imply the existence of more than three neutrino mass states and, therefore, one or more sterile neutrinos. Such sterile neutrinos, if proven to exist, would have a big impact on particle physics, nuclear physics, and astrophysics and would contribute to the dark matter of the universe. Future experiments under construction or proposed at Fermilab, ORNL, CERN, and in Japan will provide a definitive test of short-baseline neutrino oscillations and will have the capability of proving the existence of sterile neutrinos.

  18. Neutrino particle astrophysics: status and outlook

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    The discovery of astrophysical neutrinos at high energy by IceCube raises a host of questions: What are the sources? Is there a Galactic as well as an extragalactic component? How does the astrophysical spectrum continue to lower energy where the dominant signal is from atmospheric neutrinos? Is there a measureable flux of cosmogenic neutrinos at higher energy? What is the connection to cosmic rays? At what level and in what energy region should we expect to see evidence of the π0 decay photons that must accompany the neutrinos at production? Such questions are stimulating much theoretical activity and many multi-wavelength follow-up observations as well as driving plans for new detectors. My goal in this presentation will be to connect the neutrino data and their possible interpretations to ongoing multi-messenger observations and to the design of future detectors.

  19. Unbinned likelihood maximisation framework for neutrino clustering in Python

    Energy Technology Data Exchange (ETDEWEB)

    Coenders, Stefan [Technische Universitaet Muenchen, Boltzmannstr. 2, 85748 Garching (Germany)

    2016-07-01

    Albeit having detected an astrophysical neutrino flux with IceCube, sources of astrophysical neutrinos remain hidden up to now. A detection of a neutrino point source is a smoking gun for hadronic processes and acceleration of cosmic rays. The search for neutrino sources has many degrees of freedom, for example steady versus transient, point-like versus extended sources, et cetera. Here, we introduce a Python framework designed for unbinned likelihood maximisations as used in searches for neutrino point sources by IceCube. Implementing source scenarios in a modular way, likelihood searches on various kinds can be implemented in a user-friendly way, without sacrificing speed and memory management.

  20. Sterile Neutrino Search with the Double Chooz Experiment

    Science.gov (United States)

    Hellwig, D.; Matsubara, T.; Double Chooz Collaboration

    2017-09-01

    Double Chooz is a reactor antineutrino disappearance experiment located in Chooz, France. A far detector at a distance of about 1 km from reactor cores is operating since 2011; a near detector of identical design at a distance of about 400 m is operating since begin 2015. Beyond the precise measurement of θ 13, Double Chooz has a strong sensitivity to so called light sterile neutrinos. Sterile neutrinos are neutrino mass states not taking part in weak interactions, but may mix with known neutrino states. In this paper, we present an analysis method to search for sterile neutrinos and the expected sensitivity with the baselines of our detectors.

  1. The Walking Interventions Through Texting (WalkIT) Trial: Rationale, Design, and Protocol for a Factorial Randomized Controlled Trial of Adaptive Interventions for Overweight and Obese, Inactive Adults.

    Science.gov (United States)

    Hurley, Jane C; Hollingshead, Kevin E; Todd, Michael; Jarrett, Catherine L; Tucker, Wesley J; Angadi, Siddhartha S; Adams, Marc A

    2015-09-11

    the first studies focusing on the individual components of combined goal setting and reward structures in a factorial design to increase walking. The trial is expected to produce results useful to future research interventions and perhaps industry initiatives, primarily focused on mHealth, goal setting, and those looking to promote behavior change through performance-based incentives. ClinicalTrials.gov NCT02053259; https://clinicaltrials.gov/ct2/show/NCT02053259 (Archived by WebCite at http://www.webcitation.org/6b65xLvmg).

  2. Neutrino Physics at Drexel

    Energy Technology Data Exchange (ETDEWEB)

    Lane, Charles [Drexel Univ., Philadelphia, PA (United States); Dolinski, Michelle [Drexel Univ., Philadelphia, PA (United States); Neilson, Russell [Drexel Univ., Philadelphia, PA (United States)

    2017-07-11

    Our primary goal is to improve the understanding of the properties and interactions of neutrinos. We are pursuing this by means of the DUNE long-baseline and PROSPECT short-baseline neutrino experiments. For DUNE, a neutrino beam from Fermilab will be detected at the SURF facility in South Dakota, with the aim of determining the neutrino mass hierarchy (the mass ordering of neutrino flavors), and a measurement or limit on CP-violation via neutrinos. Our near-term experimental goal is to improve the characterization of the neutrino beam by measurements of muons produced as a byproduct of neutrino beam generation, to quantify the beam composition and flux. The short-range neutrino program has the aim of using the HFIR reactor at Oak Ridge as a neutrino source, with a detector placed nearby to find if there are short-distance oscillations to sterile neutrino flavors, and to resolve the 'reactor neutrino spectral anomaly' which has shown up as an unexplained 'bump' in the neutrino energy spectrum in recent experiments.

  3. Neutrino physics at a muon collider

    International Nuclear Information System (INIS)

    King, B.J.

    1998-02-01

    This paper gives an overview of the neutrino physics possibilities at a future muon storage ring, which can be either a muon collider ring or a ring dedicated to neutrino physics that uses muon collider technology to store large muon currents. After a general characterization of the neutrino beam and its interactions, some crude quantitative estimates are given for the physics performance of a muon ring neutrino experiment (MURINE) consisting of a high rate, high performance neutrino detector at a 250 GeV muon collider storage ring. The paper is organized as follows. The next section describes neutrino production from a muon storage rings and gives expressions for event rates in general purpose and long baseline detectors. This is followed by a section outlining a serious design constraint for muon storage rings: the need to limit the radiation levels produced by the neutrino beam. The following two sections describe a general purpose detector and the experimental reconstruction of interactions in the neutrino target then, finally, the physics capabilities of a MURINE are surveyed

  4. Neutrino physics in the spotlight

    CERN Multimedia

    2009-01-01

    Following on from the Council recommendation made in Lisbon in 2006 and responding to the needs of a large community of scientists, CERN will organize the European Strategy for Future Neutrino Physics workshop on 1-3 October. One of the main goals of the workshop is to start establishing a roadmap for the coherent participation of Europe in neutrino physics."The format of the workshop will consist of invited talks to present the current situation and future possibilities; unlike other workshops, 30% of the time will be reserved for discussion", explains Ewa Rondio from the organising committee. "Resources for future neutrino experiments will be difficult to acquire. A coordinated approach and the participation of a large community of interested scientists are undoubtedly crucial factors". The workshop will be the opportunity to highlight the areas where substantial research and development activities are required in order to design the facilities of the next decade. "The w...

  5. Using ProModel as a simulation tools to assist plant layout design and planning: Case study plastic packaging factory

    OpenAIRE

    Pochamarn Tearwattanarattikal; Suwadee Namphacharoen; Chonthicha Chamrasporn

    2008-01-01

    This study is about the application of a Simulation Model to assist decision making on expanding capacity and plant layout design and planning. The plant layout design concept is performed first to create the physical layouts then the simulation model used to test the capability of plant to meet various demand forecast scena. The study employed ProModel package as a tool, using the model to compare the performances in term of % utilization, characteristics of WIP and ability to meet due date....

  6. The Neutrinos Saga

    International Nuclear Information System (INIS)

    La Souchere, Marie-Christine de; Moran, John

    2009-04-01

    The author proposes a history of the discovery and study of neutrinos. This history starts shortly after the discovery of radioactivity in 1896 with the observation of an inhomogeneous deceleration of electrons in the radioactive source which raised an issue of shortage of energy. Pauli then introduced the idea of a ghost particle which could preserve the principle of energy conservation and also the issue of statistics related to the laws of quantum mechanics. Works by the Joliot-Curies and Chadwick resulted in the identification of a neutral particle, first called a neutron, and then neutrino. The author then reports experiments performed to highlight neutrinos, and to identify different forms of neutrinos: muon, tau, lepton. She also addresses questions raised by solar neutrinos, experiments proving the metamorphosis of electron neutrinos into muon neutrinos. She discusses the interest of neutrino as cosmic messengers as they are emitted by various cosmic events, and also as a way to study dark matter

  7. Ghost basis for neutrino

    International Nuclear Information System (INIS)

    Novello, M.

    1976-07-01

    A class of solutions of DIRAC'S equation in gravitational fields for ghost neutrinos is given. Comments are restricted to the neutrino cosmological model recently found by M. Novello e I.D. Soares [pt

  8. A measurement of neutrino oscillations with muon neutrinos in the MINOS experiment

    Energy Technology Data Exchange (ETDEWEB)

    Coleman, Stephen James [College of William and Mary, Williamsburg, VA (United States)

    2011-05-01

    Experimental evidence has established that neutrino flavor states evolve over time. A neutrino of a particular flavor that travels some distance can be detected in a different neutrino flavor state. The Main Injector Neutrino Oscillation Search (MINOS) is a long-baseline experiment that is designed to study this phenomenon, called neutrino oscillations. MINOS is based at Fermilab near Chicago, IL, and consists of two detectors: the Near Detector located at Fermilab, and the Far Detector, which is located in an old iron mine in Soudan, MN. Both detectors are exposed to a beam of muon neutrinos from the NuMI beamline, and MINOS measures the fraction of muon neutrinos that disappear after traveling the 734 km between the two detectors. One can measure the atmospheric neutrino mass splitting and mixing angle by observing the energy-dependence of this muon neutrino disappearance. MINOS has made several prior measurements of these parameters. Here I describe recently-developed techniques used to enhance our sensitivity to the oscillation parameters, and I present the results obtained when they are applied to a dataset that is twice as large as has been previously analyzed. We measure the mass splitting Δm232 = (2.32-0.08+0.12) x 10-3 eV2/c4 and the mixing angle sin2(2θ32) > 0.90 at 90% C.L. These results comprise the world's best measurement of the atmospheric neutrino mass splitting. Alternative disappearance models are also tested. The neutrino decay hypothesis is disfavored at 7.2σ and the neutrino quantum decoherence hypothesis is disfavored at 9.0σ.

  9. Again on neutrino oscillations

    International Nuclear Information System (INIS)

    Bilenky, S.M.; Pontecorvo, B.

    1976-01-01

    The general case is treated of a weak interaction theory in which a term violating lepton charges is present. In such a scheme the particles with definite masses are Majorana neutrinos (2N if in the weak interaction participate N four-component neutrinos). Neutrino oscillations are discussed and it is shown that the minimum average intensity at the earth of solar neutrinos is 1/2N of the intensity expected when oscillations are absent

  10. Leptogenesis and neutrino masses

    International Nuclear Information System (INIS)

    Pluemacher, M.

    2004-01-01

    Thermal leptogenesis explains the baryon asymmetry of the universe by the out-of-equilibrium decays of heavy right-handed neutrinos. In the minimal seesaw model this leads to interesting implications for light neutrino properties. In particular, quasi-degenerate light neutrino masses are incompatible with leptogenesis. An upper bound on light neutrino masses of 0.1 eV can be derived, which will be tested by forthcoming laboratory experiments and cosmology. (author)

  11. Neutrino masses and mixings

    International Nuclear Information System (INIS)

    Wolfenstein, L.

    1991-01-01

    Theoretical prejudices, cosmology, and neutrino oscillation experiments all suggest neutrino mass are far below present direct experimental limits. Four interesting scenarios and their implications are discussed: (1) a 17 keV ν τ , (2) a 30 ev ν τ making up the dark matter, (3) a 10 -3 ev ν μ to solve the solar neutrino problem, and (4) a three-neutrino MSW solution

  12. Geo-neutrino Observation

    International Nuclear Information System (INIS)

    Dye, S. T.; Alderman, M.; Batygov, M.; Learned, J. G.; Matsuno, S.; Mahoney, J. M.; Pakvasa, S.; Rosen, M.; Smith, S.; Varner, G.; McDonough, W. F.

    2009-01-01

    Observations of geo-neutrinos measure radiogenic heat production within the earth, providing information on the thermal history and dynamic processes of the mantle. Two detectors currently observe geo-neutrinos from underground locations. Other detection projects in various stages of development include a deep ocean observatory. This paper presents the current status of geo-neutrino observation and describes the scientific capabilities of the deep ocean observatory, with emphasis on geology and neutrino physics.

  13. Neutrino hierarchy from CP-blind observables with high density magnetized detectors

    International Nuclear Information System (INIS)

    Donini, A.; Fernandez-Martinez, E.; Rigolin, S.; Migliozzi, P.; Scotto Lavina, L.; Selvi, M.; Tabarelli de Fatis, T.; Terranova, F.

    2008-01-01

    High density magnetized detectors are well suited to exploit the outstanding purity and intensities of novel neutrino sources like neutrino factories and beta beams. They can also provide independent measurements of leptonic mixing parameters through the observation of atmospheric muon-neutrinos. In this paper, we discuss the combination of these observables from a multi-kT iron detector and a high energy beta beam; in particular, we demonstrate that even with moderate detector granularities the neutrino mass hierarchy can be determined for θ 13 values greater than 4 . (orig.)

  14. Detectors and flux instrumentation for future neutrino facilities

    CERN Document Server

    Abe, T.; Andreopoulos, C.; Ankowski, A.; Badertscher, A.; Battistoni, G.; Blondel, A.; Bouchez, J.; Bross, A.; Bueno, A.; Camilleri, L.; Campagne, Jean-Eric; Cazes, A.; Cervera-Villanueva, A.; De Lellis, G.; Di Capua, F.; Ellis, Malcolm; Ereditato, A.; Esposito, L.S.; Fukushima, C.; Gschwendtner, E.; Gomez-Cadenas, J.J.; Iwasaki, M.; Kaneyuki, K.; Karadzhov, Y.; Kashikhin, V.; Kawai, Y.; Komatsu, M.; Kozlovskaya, E.; Kudenko, Y.; Kusaka, A.; Kyushima, H.; Longhin, A.; Marchionni, A.; Marotta, A.; McGrew, C.; Menary, S.; Meregaglia, A.; Mezzeto, M.; Migliozzi, P.; Mondal, N.K.; Montanari, C.; Nakadaira, T.; Nakamura, M.; Nakumo, H.; Nakayama, H.; Nelson, J.; Nowak, J.; Ogawa, S.; Peltoniemi, J.; Pla-Dalmau, A.; Ragazzi, S.; Rubbia, A.; Sanchez, F.; Sarkamo, J.; Sato, O.; Selvi, M.; Shibuya, H.; Shozawa, M.; Sobczyk, J.; Soler, F.J.P.; Strolin, Paolo Emilio; Suyama, M.; Tanak, M.; Terranova, F.; Tsenov, R.; Uchida, Y.; Weber, A.; Zlobin, A.

    2009-01-01

    This report summarises the conclusions from the detector group of the International Scoping Study of a future Neutrino Factory and Super-Beam neutrino facility. The baseline detector options for each possible neutrino beam are defined as follows: 1. A very massive (Megaton) water Cherenkov detector is the baseline option for a sub-GeV Beta Beam and Super Beam facility. 2. There are a number of possibilities for either a Beta Beam or Super Beam (SB) medium energy facility between 1-5 GeV. These include a totally active scintillating detector (TASD), a liquid argon TPC or a water Cherenkov detector. 3. A 100 kton magnetized iron neutrino detector (MIND) is the baseline to detect the wrong sign muon final states (golden channel) at a high energy (20-50 GeV) neutrino factory from muon decay. A 10 kton hybrid neutrino magnetic emulsion cloud chamber detector for wrong sign tau detection (silver channel) is a possible complement to MIND, if one needs to resolve degeneracies that appear in the $\\delta$-$\\theta_{13}$...

  15. A muon storage ring for neutrino beams

    International Nuclear Information System (INIS)

    Lee, W.; Neuffer, D.

    1988-01-01

    A muon storage ring can provide electron and muon neutrino beams of precisely knowable flux. Constraints on muon collection and storage-ring design are discussed. Sample muon storage rings are presented and muon and neutrino intensities are estimated. Experimental use of the ν-beams, detector properties, and possible variations are described. Future directions for conceptual designs are outlined. 11 refs., 4 figs., 3 tabs

  16. Technology Development for a Neutrino Astrophysical Observatory

    International Nuclear Information System (INIS)

    Chaloupka, V.; Cole, T.; Crawford, H.J.; He, Y.D.; Jackson, S.; Kleinfelder, S.; Lai, K.W.; Learned, J.; Ling, J.; Liu, D.; Lowder, D.; Moorhead, M.; Morookian, J.M.; Nygren, D.R.; Price, P.B.; Richards, A.; Shapiro, G.; Shen, B.; Smoot, George F.; Stokstad, R.G.; VanDalen, G.; Wilkes, J.; Wright, F.; Young, K.

    1996-01-01

    We propose a set of technology developments relevant to the design of an optimized Cerenkov detector for the study of neutrino interactions of astrophysical interest. Emphasis is placed on signal processing innovations that enhance significantly the quality of primary data. These technical advances, combined with field experience from a follow-on test deployment, are intended to provide a basis for the engineering design for a kilometer-scale Neutrino Astrophysical Observatory

  17. Towards neutrino astronomy

    International Nuclear Information System (INIS)

    Lagage, P.O.; Spiro, M.

    1985-01-01

    Neutrino sources are numerous and varied; the sun, a supernova explosion, the cosmic radiation interaction with interstellar medium are neutrino or antineutrino sources. The aim of this article is to overview the international projects of neutrino detection while giving the preference to the experimental side of the detection [fr

  18. Neutrino disintegration of deuterium

    International Nuclear Information System (INIS)

    Ying, S.; Haxton, W.; Henley, E.M.

    1989-01-01

    We calculate the rate of both neutral- and charged-current neutrino and antineutrino disintegration of deuterium. These rates are of interest for solar 8 B and hep ( 3 He + p) spectra and supernovae neutrinos, and are relevant for the Sudbury Neutrino Observatory (SNO)

  19. Reconstructing Neutrino Mass Spectrum

    OpenAIRE

    Smirnov, A. Yu.

    1999-01-01

    Reconstruction of the neutrino mass spectrum and lepton mixing is one of the fundamental problems of particle physics. In this connection we consider two central topics: (i) the origin of large lepton mixing, (ii) possible existence of new (sterile) neutrino states. We discuss also possible relation between large mixing and existence of sterile neutrinos.

  20. Particle Astrophysics of Neutrinos

    Indian Academy of Sciences (India)

    Amol Dighe

    Energy spectra of neutrino sources. ASPERA. Page 4. Some unique features of neutrinos. The second most abundant particles in the universe. Cosmic microwave background photons: 400 / cm3. Cosmic background neutrinos: 330 / cm3. The lightest massive particles. A million times lighter than the electron. No direct mass ...