WorldWideScience

Sample records for nazarewicz dario vretenar

  1. Dario Fo irvitused Sadamateatris / Riho Laurisaar

    Index Scriptorium Estoniae

    Laurisaar, Riho

    2006-01-01

    Dario Fo "Müsteerium buff" Tartu Sadamateatris Viljandi Kultuuriakadeemia teatrikunsti õppetooli kolmanda kursuse ehk kuuenda lennu tudengite esituses. Näitemängu on lavastanud Peeter Raudsepp. Esietendus 25. apr

  2. Dario Fo irvitused Sadamateatris / Riho Laurisaar

    Index Scriptorium Estoniae

    Laurisaar, Riho

    2006-01-01

    Dario Fo "Müsteerium buff" Tartu Sadamateatris Viljandi Kultuuriakadeemia teatrikunsti õppetooli kolmanda kursuse ehk kuuenda lennu tudengite esituses. Näitemängu on lavastanud Peeter Raudsepp. Esietendus 25. apr

  3. Le "Décaméron" de Dario Fo

    Directory of Open Access Journals (Sweden)

    Marco Galiero

    2014-12-01

    Full Text Available The starting-point for this article is the interest that Dario Fo has repeatedly shown in the Middle Ages, as well as the concept of “transcodage pragmatique” (Youri Lotman. Thereafter, the essay concentrates on the rewritings of some tales contained Decameron, which Fo presented to his spectators in 2010 and to his readers in 2011. Examining Fo’s reuses of his sources and analysing the dissimilarities between the latter and Fo’s creations, the article will then turn to the active process of rereading and rewriting, along with the refunctionalization of artistic productions.

  4. DARIO: a ncRNA detection and analysis tool for next-generation sequencing experiments

    Science.gov (United States)

    Fasold, Mario; Langenberger, David; Binder, Hans; Stadler, Peter F.; Hoffmann, Steve

    2011-01-01

    Small non-coding RNAs (ncRNAs) such as microRNAs, snoRNAs and tRNAs are a diverse collection of molecules with several important biological functions. Current methods for high-throughput sequencing for the first time offer the opportunity to investigate the entire ncRNAome in an essentially unbiased way. However, there is a substantial need for methods that allow a convenient analysis of these overwhelmingly large data sets. Here, we present DARIO, a free web service that allows to study short read data from small RNA-seq experiments. It provides a wide range of analysis features, including quality control, read normalization, ncRNA quantification and prediction of putative ncRNA candidates. The DARIO web site can be accessed at http://dario.bioinf.uni-leipzig.de/. PMID:21622957

  5. Poza zasadą własności. Recenzja tomu Differenze italiane. Politica e filosofia: mappe e sconfinamenti pod redakcją Dario Gentiliego i Elettry Stimilli.

    Directory of Open Access Journals (Sweden)

    Piotr Sadzik

    2015-04-01

    Full Text Available Tekst ten jest recenzją tomu pod redakcją Dario Gentiliego i Elettry Stimilli pt. Różnice włoskie. Polityka i filozofia: mapy i przekroczenia granic. Dyskutuje on zasadność mówienia o “Italian Theory” lub “myśli włoskiej” oraz rekonstruuje najważniejsze cechy charakterystyczny współczesnej włoskiej filozofii politycznej w opariu o recenzowany tom oraz inne publikacje m.in. Roberta Esposito. Pod koniec recenzji autor formułuje także krytyczne uwagi pod adresem roli, jaką w pismach wielu włoskich filozofów odgrywa filozofia francuska, zwłaszcza dekonstrukcja Jacques’a Derridy.

  6. Education in Parana in the teachers’ formation process in republican Brazil: the contribution of the compendium of pedagogy by Dario Vellozo - doi: 10.4025/actascieduc.v34i2.18295

    Directory of Open Access Journals (Sweden)

    Marlete dos Anjos Silva Schaffrath

    2012-11-01

    Full Text Available The work has a result the study on the Compendium of Pedagogy (1907 by Dario Vellozo (1869-1937, teacher of Ginasio Paranaense and Escola Normal de Curitiba. The Compendium of Pedagogy by Vellozo was published in 1907 and republished in 1975. It was organized in three parts, one for every year of Teachers’ School. The article refers to the first book of the collection. In the first part of that book, there are ten lessons which covers the Pedagogy subject and their methods, organization of school and definitions of educations, as well as several lessons about Ancient, Medieval and Modern History and the prevailing educational thought in each one of them. The book for the second year, which was also organized in ten lesson, emphasizes the teaching methods, didactics, and physical education (health, moral, intellectual aspects. For the third year of course, Vellozo writes lessons about science, geography, history, drawing, music and a special lesson about kindergartens. The Compendium follows the scientific logics that should guide the school practices in that historical period, but also reflects the current culture in Teachers’ School, as well as  it shows the social-economic, political and cultural influences in Brazil and in Parana.  

  7. Boletines de tierra: Vargas Vila, Dario, otros

    Directory of Open Access Journals (Sweden)

    Humberto Jaramillo Ángel

    1967-06-01

    Full Text Available En Roma. Cuando aún no había fenecido, del todo, el año 1900. El Maestro vivía solo. Muy solo, en la ciudad Imperial. Leía. Escribía. Odiaba. Y era odiado. Su lucha, lucha de cóndor con águila caudal, no cesaba a ninguna hora del día o de la noche.

  8. Dario Fo and the dramaturgy of irreverence

    African Journals Online (AJOL)

    In the manner of an agent provocateur, the madman cons the policemen into revealing the ..... spectacles hanging from their necks by little gold chains, otherwise they would lose .... government ruthlessly suppressed pro-democracy demonstrations by killing and arresting thousands .... The Tricks of the Trade. Joe Farrell, tr.

  9. Dario Battistella, Théories des relations internationales

    OpenAIRE

    Blanchard, Jean-François

    2016-01-01

    Les soubresauts de l’Histoire contemporaine tempèrent régulièrement l’ambition scientifique des internationalistes. Certains d’eux ont vécu le 11 septembre 2001 comme «  la surprise conceptuelle absolue  » (p. 561). De toute évidence, la construction d’une théorie des relations internationales (R.I.) dédiée à la compréhension et à l’explication de la structure anarchique (p. 26) du milieu international n’apparait pas évidente. Depuis que la discipline existe sous sa forme moderne (1918), l’oc...

  10. Prevalence of obesity and associated cardiovascular risk: the DARIOS study.

    Science.gov (United States)

    Félix-Redondo, Francisco Javier; Grau, María; Baena-Díez, José Miguel; Dégano, Irene R; de León, Antonio Cabrera; Guembe, Maria Jesús; Alzamora, María Teresa; Vega-Alonso, Tomás; Robles, Nicolás R; Ortiz, Honorato; Rigo, Fernando; Mayoral-Sanchez, Eduardo; Tormo, Maria José; Segura-Fragoso, Antonio; Fernández-Bergés, Daniel

    2013-06-05

    To estimate the prevalence of overweight and obesity in the Spanish population as measured with body mass index (BMI), waist circumference (WC) and waist to height ratio (WHtR) and to determine the associated cardiovascular risk factors. Pooled analysis with individual data from 11 studies conducted in the first decade of the 21st century. Participants aged 35-74 years were asked about the history of cardiovascular diseases, hypertension, diabetes and hypercholesterolemia. Height, weight, WC, blood pressure, glycaemia, total cholesterol, low-density and high-density lipoprotein cholesterol and coronary risk were measured. The prevalence of overweight (BMI 25-29.9 kg/m(2)), general obesity (BMI ≥ 30 kg/m(2)), suboptimal WC (≥ 80 cm and European population. We included 28,743 individuals. The prevalence of overweight and suboptimal WC was 51% and 30% in men and 36% and 22% in women, respectively; general obesity was 28% in both sexes and abdominal obesity 36% in men and 55% in women. The prevalence of WHtR ≥0.5 was 89% and 77% in men and women, respectively. All cardiovascular risk factors were significantly associated with abnormal increased values of BMI, WC and WHtR. Hypertension showed the strongest association with overweight [OR = 1.99 (95% confidence interval 1.81-2.21) and OR = 2.10 (1.91-2.31)]; suboptimal WC [OR = 1.78 (1.60-1.97) and OR = 1.45 (1.26-1.66)], with general obesity [OR = 4.50 (4.02-5.04), and OR = 5.20 (4.70-5.75)] and with WHtR ≥0.5 [OR = 2.94 (2.52-3.43), and OR = 3.02 (2.66-3.42)] in men and women respectively, besides abdominal obesity in men only [OR = 3.51 (3.18-3.88)]. Diabetes showed the strongest association with abdominal obesity in women [OR = 3,86 (3,09-4,89). The prevalence of obesity in Spain was high. Overweight, suboptimal WC, general, abdominal obesity and WHtR ≥0.5 was significantly associated with diabetes, hypertension, hypercholesterolemia and coronary risk. The use of lower cut-off points for both BMI and particularly WC and could help to better identify the population at risk and therefore achieve more effective preventive measures.

  11. CONOCIMIENTO DE LA LEY GENERAL DE SALUD RESPECTO DE LAS TRANSFUSIONES SANGUÍNEAS EN MÉDICOS Y PACIENTES TESTIGOS DE JEHOVÁ DEL HOSPITAL DR. DARÍO CONTRERAS DE REPÚBLICA DOMINICANA CONHECIMENTO DA LEI GERAL DE SAÚDE - RESPEITO ÀS TRANSFUSÕES SANGUÍNEAS EM MÉDICOS E PACIENTES TESTEMUNHAS DE JEOVÁ DO HOSPITAL DR. DARÍO CONTRERAS DA REPÚBLICA DOMINICANA KNOWLEDGE OF GENERAL HEALTH LAW WITH RESPECT TO BLOOD TRANSFUSIONS BY PHYSICIANS AND PATIENTS JEHOVAH WITNESSES IN HOSPITAL DR. DARIO CONTRERAS OF DOMINICAN REPUBLIC

    Directory of Open Access Journals (Sweden)

    Elsa Díaz Santana

    2010-06-01

    Full Text Available Este estudio evalúa hasta qué grado el cuerpo médico del Hospital Dr. Darío Contreras de República Dominicana conoce, respeta, informa y aplica la Ley General de Salud, con relación al derecho del paciente Testigo de Jehová de negarse a ser transfundido (respeto a su autonomía. También si los Testigos de Jehová conocen la Ley General de Salud y hasta qué grado se han beneficiado con la puesta en marcha de la misma. El estudio reveló que ni médicos ni Testigos de Jehová conocen suficientemente dicha ley.Este estudo avalia quanto o corpo médico do Hospital Dr. Darío Contreras de República Dominicana conhece, respeita, informa e aplica a Lei Geral de Saúde em relação aos direitos do paciente Testemunha de Jeová de negar-se a ser transfundido (respeito a sua autonomia; também se os Testemunhas de Jeová conhecem a Lei Geral de Saúde e até que ponto têm se beneficiado diante dessa proposição. O estudo revelou que nem médicos, nem Testemunhas de Jeová conhecem de fato essa lei.This study evaluates up to which degree physicians of Hospital Dr. Dario Contreras of Dominican Republic know, respect, inform and apply the General Health Law in relation to the right of Jehovah witness patients to refuse being blood transfused (respect to their autonomy. It also evaluates whether Jehovah witnesses know General Health Law and in which degree they have been benefited by putting it into practice. The study reveals that Jehovah Witnesses do not know the law.

  12. How Spatial is a Whale? Places and Processes in Zoomusicology / Dario Martinelli

    Index Scriptorium Estoniae

    Martinelli, Dario

    2008-01-01

    Zoomusikoloogiast, mis uurib loomade muusikalist tegevust. Loomade muusikataoliste häälitsuste uurimisest. Heli kasutamisest loomadevahelises kommunikatsioonis, muusikast kui imitatsiooni vormist. Muusikast kui sotsiaalsest faktist

  13. How Spatial is a Whale? Places and Processes in Zoomusicology / Dario Martinelli

    Index Scriptorium Estoniae

    Martinelli, Dario

    2008-01-01

    Zoomusikoloogiast, mis uurib loomade muusikalist tegevust. Loomade muusikataoliste häälitsuste uurimisest. Heli kasutamisest loomadevahelises kommunikatsioonis, muusikast kui imitatsiooni vormist. Muusikast kui sotsiaalsest faktist

  14. Metabolic and inflammatory profiles of biomarkers in obesity, metabolic syndrome, and diabetes in a Mediterranean population. DARIOS Inflammatory study.

    Science.gov (United States)

    Fernández-Bergés, Daniel; Consuegra-Sánchez, Luciano; Peñafiel, Judith; Cabrera de León, Antonio; Vila, Joan; Félix-Redondo, Francisco Javier; Segura-Fragoso, Antonio; Lapetra, José; Guembe, María Jesús; Vega, Tomás; Fitó, Montse; Elosua, Roberto; Díaz, Oscar; Marrugat, Jaume

    2014-08-01

    There is a paucity of data regarding the differences in the biomarker profiles of patients with obesity, metabolic syndrome, and diabetes mellitus as compared to a healthy, normal weight population. We aimed to study the biomarker profile of the metabolic risk continuum defined by the transition from normal weight to obesity, metabolic syndrome, and diabetes mellitus. We performed a pooled analysis of data from 7 cross-sectional Spanish population-based surveys. An extensive panel comprising 20 biomarkers related to carbohydrate metabolism, lipids, inflammation, coagulation, oxidation, hemodynamics, and myocardial damage was analyzed. We employed age- and sex-adjusted multinomial logistic regression models for the identification of those biomarkers associated with the metabolic risk continuum phenotypes: obesity, metabolic syndrome, and diabetes mellitus. A total of 2851 subjects were included for analyses. The mean age was 57.4 (8.8) years, 1269 were men (44.5%), and 464 participants were obese, 443 had metabolic syndrome, 473 had diabetes mellitus, and 1471 had a normal weight (healthy individuals). High-sensitivity C-reactive protein, apolipoprotein B100, leptin, and insulin were positively associated with at least one of the phenotypes of interest. Apolipoprotein A1 and adiponectin were negatively associated. There are differences between the population with normal weight and that having metabolic syndrome or diabetes with respect to certain biomarkers related to the metabolic, inflammatory, and lipid profiles. The results of this study support the relevance of these mechanisms in the metabolic risk continuum. When metabolic syndrome and diabetes mellitus are compared, these differences are less marked. Copyright © 2013 Sociedad Española de Cardiología. Published by Elsevier Espana. All rights reserved.

  15. 拉美的现代主义诗歌与鲁文·达里奥%Latin America's Modernism Poetry and Ruben Dario

    Institute of Scientific and Technical Information of China (English)

    赵振江

    2006-01-01

    前些年,在外国文学界,“现代主义”和“后现代主义”这两个词很是风光,然而许多人并不清楚,作为一个文学运动,现代主义最早出现于拉丁美洲,就连后现代主义这个词也是拉美文学界最先使用的,只是当时的含义不同。在墨西哥诗人帕斯于1990年获得诺贝尔文学奖时,有人便说这是“现代主义诗歌的又一次胜利”,殊不知帕斯本人对所谓“现代”和“后现代”的提法一向是持批评态度的,因为持这种观点的人根本无视此前早已存在的、拉丁美洲的现代主义文学。诚然,帕斯与他的欧美同行之间的争论与我们本没什么关系,但却可以看出我们对拉丁美洲诗歌是相当地不了解。既然不了解现代主义诗歌,也就不大可能了解拉美现代主义诗歌的代表人物鲁文·达里奥。这正是笔者撰写本文的初衷之所在。

  16. ATLAS TV PROJECT

    CERN Multimedia

    2005-01-01

    Sequence 1 General shots of Building 40, open area for 4th floor. Sequence 2 Roger Jones arrives to meet Dario Barberis Discussion Barberis-Jones Interview Dario Barberis Interview Roger Jones Roger Jones walks down to seminar room. Sequence 3 Computer Model Meeting Talks: Roger Jones Harry Truman Quote Speaker Ian Hinchliffe (Tag testing) Speaker Don Quarrie Sequence 4 (Same meeting) LIVELY DISCUSSION Sequence 5 Talk - Dario Barberis (1.21.30) 1.25.58 END ROLL

  17. Metamaterial-Based Cylinders Used for Invisible Cloak Realization

    Science.gov (United States)

    2011-08-01

    Branimir Ivsic Tin Komljenovic University of Zagreb Faculty of Electrical Engineering and Computing Unska 3 Zagreb, Croatia HR-10000...PROGRAM ELEMENT NUMBER 61102F 6. AUTHOR(S) Zvonimir Sipus Dario Bojanjac Branimir Ivsic Tim Komljenovic 5d. PROJECT NUMBER 5d. TASK...Used for Invisible Cloak Realization by Zvonimir Sipus Dario Bojanjac Branimir Ivsic Tin Komljenovic

  18. Teatritudengid loovad müsteeriumi tehnikaga / Katrin Ruus

    Index Scriptorium Estoniae

    Ruus, Katrin

    2006-01-01

    Dario Fo "Müsterium buff" Tartu Sadamateatris Viljandi Kultuuriakadeemia teatrikunsti õppetooli kolmanda kursuse ehk kuuenda lennu tudengite esituses. Näitemängu on lavastanud Peeter Raudsepp. Esietendus 25. apr

  19. Posvjashenije Eve / Mark Levin

    Index Scriptorium Estoniae

    Levin, Mark

    2000-01-01

    Kahest lavastusest : Vene Draamateatri monoetendusest Dario Fo/F.Rame "Ootan sind, kallim" Ljubov Agapovaga, lavastaja Irina Tomingas ja Moskva Vahtangovi nim. Teatri etendusest E. Schmitti "Pühendus Eevale", lavastaja Sergei Jashin

  20. Mats võib mässama hakata ehk lugusid keskajast / Katrin Roosileht

    Index Scriptorium Estoniae

    Roosileht, Katrin

    2006-01-01

    Viljandi Kultuuriakadeemia teatrikunsti 6. lennu tudengid mängivad Tartu Sadamateatris Dario Fo farssi "Müsteerium buff", lavastaja Peeter Raudsepp, lavakujundus ja kostüüm Peeter Raudsepp ja Kersti Rattus. Esietendus 25. aprillil

  1. Kartina mira skvoz Monokl / Eteri Kekelidze

    Index Scriptorium Estoniae

    Kekelidze, Eteri, 1944-

    2001-01-01

    Sankt-Peterburgis toimus III rahvusvaheline monoetenduste festival Monokkel 2001, Eestit esindas Vene Draamateatri lavastus - Dario Fo "Ootan sind, kallim" (näitleja Ljubov Agapovaga), mis võeti soojalt vastu, kuid auhinda ei pälvinud

  2. Odin na odin so zritelem / Boris Tuch

    Index Scriptorium Estoniae

    Tuch, Boris, 1946-

    2001-01-01

    Sankt-Peterburgis toimunud III rahvusvahelisest monoetenduste festivalist Monokkel 2001. Eestit esindas Vene Draamateatri lavastus - Dario Fo "Ootan sind, kallim" (näitleja Ljubov Agapovaga), millel on ka pikemalt peatutud

  3. Ai, nad torkasid mind keelega! / Anneli Saro

    Index Scriptorium Estoniae

    Saro, Anneli, 1968-

    2006-01-01

    Dario Fo "Müsterium buff" Tartu Sadamateatris Viljandi Kultuuriakadeemia teatrikunsti õppetooli kolmanda kursuse ehk kuuenda lennu tudengite esituses. Näitemängu on lavastanud Peeter Raudsepp. Esietendus 25. apr

  4. Odin na odin so zritelem / Boris Tuch

    Index Scriptorium Estoniae

    Tuch, Boris, 1946-

    2001-01-01

    Sankt-Peterburgis toimunud III rahvusvahelisest monoetenduste festivalist Monokkel 2001. Eestit esindas Vene Draamateatri lavastus - Dario Fo "Ootan sind, kallim" (näitleja Ljubov Agapovaga), millel on ka pikemalt peatutud

  5. Posvjashenije Eve / Mark Levin

    Index Scriptorium Estoniae

    Levin, Mark

    2000-01-01

    Kahest lavastusest : Vene Draamateatri monoetendusest Dario Fo/F.Rame "Ootan sind, kallim" Ljubov Agapovaga, lavastaja Irina Tomingas ja Moskva Vahtangovi nim. Teatri etendusest E. Schmitti "Pühendus Eevale", lavastaja Sergei Jashin

  6. The Author and His Works

    Science.gov (United States)

    Spain Today, 1971

    1971-01-01

    Works of Emilio Garcia Gomez, Dario Fernandez Florez, Armando Lopez Salinas, Jaime de Arminan, Luis Lopez Anglada, and Carmen Bravo Villasante are analyzed in this continuing series on Spanish authors. (DS)

  7. Kuningal on külm / Kadi Herkül

    Index Scriptorium Estoniae

    Herkül, Kadi

    1996-01-01

    Dario Fo 'Elizabeth - naine juhuse tahtel', lavastaja Elmo Nüganen, esietendus Linnateatris 21. sept. 1996. Jaan Kruusvalli 'Hullumeelne professor, tema elukäik', lavastaja Mikk Mikiver, esietendus Draamateatris 21. sept. 1996

  8. Pop & rock / Berk Vaher

    Index Scriptorium Estoniae

    Vaher, Berk, 1975-

    2001-01-01

    Uute heliplaatide Redman "Malpractice", Brian Eno & Peter Schwalm "Popstars", Clawfinger "A Whole Lot of Nothing", Dario G "In Full Color", MLTR e. Michael Learns To Rock "Blue Night" lühitutvustused

  9. Pop & rock / Berk Vaher

    Index Scriptorium Estoniae

    Vaher, Berk, 1975-

    2001-01-01

    Uute heliplaatide Redman "Malpractice", Brian Eno & Peter Schwalm "Popstars", Clawfinger "A Whole Lot of Nothing", Dario G "In Full Color", MLTR e. Michael Learns To Rock "Blue Night" lühitutvustused

  10. Kuningal on külm / Kadi Herkül

    Index Scriptorium Estoniae

    Herkül, Kadi

    1996-01-01

    Dario Fo 'Elizabeth - naine juhuse tahtel', lavastaja Elmo Nüganen, esietendus Linnateatris 21. sept. 1996. Jaan Kruusvalli 'Hullumeelne professor, tema elukäik', lavastaja Mikk Mikiver, esietendus Draamateatris 21. sept. 1996

  11. Kompott õudusfilmifestivalil / Jaan Franclin Perlitz

    Index Scriptorium Estoniae

    Perlitz, Jaan Franclin

    2006-01-01

    Haapsalu õudusfilmifestivali filmidest : Fr. W. Murnau "Nosferatu - õuduste sümfoonia" (Saksamaa, 1922), Lõuna-Korea "R-Point", Takashi Miike "Izo" (Jaapan, 2004), itaallase Dario Argento "Ohked" ("Suspiria"), Eesti lühifilm "Hirm"

  12. Kompott õudusfilmifestivalil / Jaan Franclin Perlitz

    Index Scriptorium Estoniae

    Perlitz, Jaan Franclin

    2006-01-01

    Haapsalu õudusfilmifestivali filmidest : Fr. W. Murnau "Nosferatu - õuduste sümfoonia" (Saksamaa, 1922), Lõuna-Korea "R-Point", Takashi Miike "Izo" (Jaapan, 2004), itaallase Dario Argento "Ohked" ("Suspiria"), Eesti lühifilm "Hirm"

  13. Kartina mira skvoz Monokl / Eteri Kekelidze

    Index Scriptorium Estoniae

    Kekelidze, Eteri, 1944-

    2001-01-01

    Sankt-Peterburgis toimus III rahvusvaheline monoetenduste festival Monokkel 2001, Eestit esindas Vene Draamateatri lavastus - Dario Fo "Ootan sind, kallim" (näitleja Ljubov Agapovaga), mis võeti soojalt vastu, kuid auhinda ei pälvinud

  14. Ai, nad torkasid mind keelega! / Anneli Saro

    Index Scriptorium Estoniae

    Saro, Anneli, 1968-

    2006-01-01

    Dario Fo "Müsterium buff" Tartu Sadamateatris Viljandi Kultuuriakadeemia teatrikunsti õppetooli kolmanda kursuse ehk kuuenda lennu tudengite esituses. Näitemängu on lavastanud Peeter Raudsepp. Esietendus 25. apr

  15. Rock Art Glossary: A Multilingual Dictionary, Expanded Second Edition (First Edition 2001. Edited by Robert G. Bednarik, Ahmed Achrati, Tang Huisheng, Alfred Muzzolini, George Dimitriadis, Dario Seglie, Fernando Coimbra, Yakov A. Sher and Mario Consens. Australian Rock Art Research Association, Inc., Melbourne, 2010; 274 Pages, in English, Arabic, Chinese, French, German, Greek, Italian, Portuguese, Russian and Spanish, with Translation Tables. Price $A 38.00, ISBN 978-0-646-53471-8

    Directory of Open Access Journals (Sweden)

    Shu-Kun Lin

    2013-02-01

    Full Text Available This is the first dictionary compiled specifically for rock art research. It follows the publication of an English rock art glossary in the journal Rock Art Research in November 2000. To be adopted by the International Federation of Rock Art Organisations (IFRAO, it has been translated by some of the world’s foremost scholars in the field into Arabic, Chinese, French, German, Greek, Italian, Portuguese, Spanish and Russian. In a discipline that has hitherto been without an agreed terminology, even communication within a single language has been difficult. The proliferation of idiosyncratic terminologies of often academically isolated researchers, many of which have been used by only one scholar, has not only retarded progress and the transference of knowledge, it has led to countless misunderstandings and even personal feuds. The purpose of this dictionary is to create a single terminological standard as well as a cross-lingual uniformity of usage. It focuses particularly on scientific aspects, technical applications and epistemological rigour. It does not set out to create a terminological straitjacket for the discipline, but a common standard of reference, particularly in areas that have in the past been susceptible to greatly differing interpretations. This dictionary comprises sections in ten languages, each listing the same terms alphabetically. It also contains a table interlinking all of these languages, listing all terms explained. This translation table is organised alphabetically according to the English terms. The volume is indispensable for scientific translators, rock art scholars, archaeologists and others concerned with aspects of pre-Historic rock art, and is also intended for the guidance of students and authors working in this field.

  16. Pigem klaas kihisevat kui Ferrari / Sathnam Sanghera ; tõlk. Erik Aru

    Index Scriptorium Estoniae

    Sanghera, Sathnam

    2005-01-01

    Autor kirjeldab oma kohtumist Ferrari peatestisõitja Dario Benuzziga ja GlaxoSmithKline'i mustsõstrajoogi Ribena maitsja Isobel Hoare'iga ning järeldab, et võib teha tööga rahulolu olemusest järeldusi, mida eksperdid ei näi märkavat

  17. An Outline Course on Human Performance Modeling

    Science.gov (United States)

    2006-01-01

    complementary or competing tasks: Dario SaIvucci, ??? 46. Bonnie Johns, David Kieras 47. ecological interface design 48. More into modeling human... alarcon 70. Ben Knott 71. Evelyn Rozanski 7.Pete Khooshabeh Optional: If ou would like to be on a mailin list for further seminars lease enter our email

  18. U.S. Policy and Latin America in the 1990’s

    Science.gov (United States)

    1992-01-01

    Boliva: Land of Struggle. Boulder: Westview, 1992. (F 3321 .M75 1992) Moreno, Dario . U.S. Policy in Central America: The Endless Debate. Miami: Florida...California P, 1991. (HC 147 .Z44 1991) 21 Journals Alarcon , Diana, and Terry McKinley. "Beyond Import Substitution: The Restructuring Projects of Bra. ’.1

  19. Kuues lend / Rait Avestik

    Index Scriptorium Estoniae

    Avestik, Rait, 1974-

    2007-01-01

    Tartu Ülikooli Viljandi kultruuriakadeemia teatrikunsti VI lennu diplomilavastused: Dario Fo "Müsterium buff", lavastaja Peeter Raudsepp; Anton Tshehhovi "Kolm õde", lavastaja-koreograaf Oleg Titov; Janusz Glowacki "Fortinbras jõi end täis", lavastajad Kalju Komissaarov ja Sven Heiberg. Lühidalt uutest diplomeeritud lavastajatest - Jaanika Juhanson ja Kati Kivitar

  20. "Blue-Collar Blues" uurib töösuhteid uutes oludes / Janar Ala

    Index Scriptorium Estoniae

    Ala, Janar, 1979-

    2009-01-01

    Tööproblemaatikat käsitlev näitus "Blue-Collar Blues" Tallinna Kunstihoones ja Tallinna Kunstihoone galeriis 31. jaanuarini 2010, kuraator Anders Härm. Lähemalt belgia-mehhiko kunstniku Francis Alys'e videost, austria kunstniku Oliver Ressleri ning venetsueela-saksa politoloogi Dario Azzelini videost "Viis tehast. Tööliste kontroll Venezuelas"

  1. Design and Fabrication of a Reciprocal Trees Pavilion

    DEFF Research Database (Denmark)

    Parigi, Dario

    2014-01-01

    to traditional construction systems. The geometry of the network of elements is a property emerging, bottom-up, from the complex and simultaneous interaction among all the elements in the configuration. The structure was designed using the “Reciprocalizer”, an agile deign tool for reciprocal structures developed...... by Dario Parigi and fabricated with a purposely developed fabrication machine....

  2. El modernismo en Pluma i Lápiz (revista literaria 1900-1904)

    National Research Council Canada - National Science Library

    Galgani Muñoz, Jaime

    2013-01-01

    ... a otras revistas que simpatizaron mas con el realismo y el naturalismo. Ambas corrientes constituyen, sin duda, dos ventanas ineludibles para contemplar el paisaje estetico con que Latinoamerica saludo al nuevo siglo. La hipotesis fundamental de este trabajo postula que la revista escogida activa una defensa critica del modernismo. Admira a Dario...

  3. "Blue-Collar Blues" uurib töösuhteid uutes oludes / Janar Ala

    Index Scriptorium Estoniae

    Ala, Janar, 1979-

    2009-01-01

    Tööproblemaatikat käsitlev näitus "Blue-Collar Blues" Tallinna Kunstihoones ja Tallinna Kunstihoone galeriis 31. jaanuarini 2010, kuraator Anders Härm. Lähemalt belgia-mehhiko kunstniku Francis Alys'e videost, austria kunstniku Oliver Ressleri ning venetsueela-saksa politoloogi Dario Azzelini videost "Viis tehast. Tööliste kontroll Venezuelas"

  4. Kuues lend / Rait Avestik

    Index Scriptorium Estoniae

    Avestik, Rait, 1974-

    2007-01-01

    Tartu Ülikooli Viljandi kultruuriakadeemia teatrikunsti VI lennu diplomilavastused: Dario Fo "Müsterium buff", lavastaja Peeter Raudsepp; Anton Tshehhovi "Kolm õde", lavastaja-koreograaf Oleg Titov; Janusz Glowacki "Fortinbras jõi end täis", lavastajad Kalju Komissaarov ja Sven Heiberg. Lühidalt uutest diplomeeritud lavastajatest - Jaanika Juhanson ja Kati Kivitar

  5. “Chacun son Marcel”? Meerduidigheid in het werk van Marcel Duchamp

    NARCIS (Netherlands)

    Jansen, Hubert Marie Lambert (Bert)

    2015-01-01

    In my overview of the reception of Duchamp I examine the plurality of possible approaches. I demonstrate that the cause of this diversity is primarily a result of the ambiguity of Duchamp. Dario Gamboni's conception of the artwork as a potential image allowed me to consider diverse views about Ducha

  6. Elections to the Senior Staff Advisory Committee (“The Nine”) 2015

    CERN Multimedia

    Tim Smith, ex-spokesperson of the "Nine"

    2015-01-01

    The electronic voting process for the Senior Staff Advisory Committee (“The Nine”) was closed on Friday 28 August 2015 at 17:30.   Of the 526 Senior Staff members eligible to vote, 275 voted. This represents a participation of 52%, to be compared to 59% in 2014, 63% in 2013, 61% in 2012, 43% in 2011, 44% in 2010, 57% in 2009, 53% in 2008, 63% in 2007, 64% in 2006 and 66% in 2005. The results are:   Electoral group 2 (Applied Physicists, Engineers, Computer Scientists) Candidate Dept Votes Result Sergio CALATRONI TE 50   Marco CATTANEO PH 76 ELECTED Maria DIMOU IT 44   Fabio FORMENTI TE 51   John JOWETT BE 68   Maarten LITMAATH IT 26   John SHADE IT 28   Raymond VENESS BE 103 ELECTED Payol VOITYLA DGS 12   Maurizio VRETENAR DG 100 ELECTED   Electoral group 3 (Administration, Human Resource...

  7. Search for excited superdeformed bands in {sup 151}Dy

    Energy Technology Data Exchange (ETDEWEB)

    Nisius, D.; Janssens, R.V.F.; Crowell, B. [and others

    1995-08-01

    Following the first report of superdeformed (SD) bands with identical transition energies in the pairs ({sup 151}Tb*,{sup 152}Dy), ({sup 150}Gd*, {sup 151}Tb) and ({sup 153}Dy*, {sup 152}Dy) (where * denotes an excited SD band), it was proposed by Nazarewicz et al. that the observations could be understood in a strong-coupling approach if pseudo SU(3) symmetry were invoked. In this model there are three limiting values of the decoupling parameter; i.e. a = 0, {plus_minus}1. In the first two cases mentioned above the pairs of bands have nearly identical transition energies and are interpreted as proton excitations involving the [200]1/2 pseudospin orbital coupled to the {sup 152}Dy core, for which the value of the decoupling parameter is calculated to be a =+1.

  8. El género poemático del blasón bajo el signo de Darío: artes poéticas de aves, naturalezas nativas y voces únicas en dos poetas peruanos

    Directory of Open Access Journals (Sweden)

    Alexis Iparraguirre

    2010-12-01

    Full Text Available The paper explains the peculiarities of the poetic gender called blasón thatRubén Dario assumes in the poem of the same name. It shows that Darío’snotion of blasón introduces substantial changes to this gender, which originally implies the praise of a shield, and uses it as an ars poetica. So thepoems entitled “Blasón” of Jose Santos Chocano and Jose María Eguren,according to Dario, become the expression of an aesthetic program throughthree recurring images: a bird and/or the so-called “American nature”,and/or of the poetic voice that declares its fierce singularity.

  9. Reseñas

    OpenAIRE

    Anales de Literatura Española

    1986-01-01

    Contiene: Un filosofo alla corte di Bisancio : MICHELE PSELLO Imperatori di Bisanzio (Cronografia). Introduzione di Dario Del Corno, testo critico a cura di Salvatore Impellizzeri, commento di Ugo Criscuolo, traduzione di Silvia Ronchey. Fondazione Lorenzo Valla-Mondadori, Milano, 1984, 2 vol. / STEFANO ARDUINI ; Una edición de Antonio de Guevara : ANTONIO DE GUEVARA Menosprecio de corte y alabanza de aldea. Arte de marear. Edición de Asunción Rallo. Madrid, C...

  10. Canakinumab as rescue therapy in familial Mediterranean fever refractory to conventional treatment

    OpenAIRE

    Alpa M; Roccatello D

    2015-01-01

    Mirella Alpa, Dario Roccatello Centro di Ricerche di Immunopatologia e Documentazione su Malattie Rare (CMID), Struttura Complessa Direzione Universitaria di Immunologia Clinica, Università di Torino e Ospedale G Bosco, Torino, ItalyAbstract: Familial Mediterranean fever is an autosomal recessive autoinflammatory disorder mainly affecting Mediterranean populations, which is associated with mutations of the MEFV gene that encodes pyrin. Functional studies suggest that pyrin is impli...

  11. Long-term outcomes in chronic obstructive pulmonary disease patients: exploring the effects of inhalatory devices and their influence on the outcome

    OpenAIRE

    Fadda V; Maratea D

    2016-01-01

    Valeria Fadda, Dario Maratea Department of Pharmaceutical Sciences, University of Florence, Sesto Fiorentino, FI, Italy Purpose: Numerous systematic reviews have examined the outcomes in patients with chronic obstructive pulmonary disease managed with different therapeutic strategies. However, no such studies have specifically focused on the effect of inhalation devices. Methods: A standard PubMed search was carried out in which we identified all randomized placebo-controlled trials conducte...

  12. Mechanisms of CTC Biomarkers in Breast Cancer Brain Metastasis

    Science.gov (United States)

    2015-10-01

    represents the most devastating and feared consequence of breast cancer . BCBM is usually fatal and is increasing in frequency with occult brain...metastatic breast cancer (stage IV) patients with or without clinically diagnosed BCBM employing multiparametric flow cytometry (FACS; ARIA IIID system)(10...AWARD NUMBER: W81XWH-14-1-0214 TITLE: Mechanisms of CTC Biomarkers in Breast Cancer Brain Metastasis PRINCIPAL INVESTIGATOR: Dario

  13. Diabetes reversal via gene transfer: building on successes in animal models

    OpenAIRE

    Gerace D.; Martiniello-Wilks R; Simpson AM

    2015-01-01

    Dario Gerace,1,* Rosetta Martiniello-Wilks,1,2,* Ann M Simpson1 1School of Medical and Molecular Biosciences, Centre for Health Technologies, 2Translational Cancer Research Group, University of Technology Sydney, Sydney, NSW, Australia  *These authors contributed equally to this work Abstract: Type 1 diabetes (T1D) is caused by the autoimmune destruction of the insulin-producing pancreatic β-cells. People with T1D manage their hyperglycemia using daily insulin injections; h...

  14. Evaluation of Mechanical Ventilator Use with Liquid Oxygen Systems

    Science.gov (United States)

    2017-02-22

    AFRL-SA-WP-SR-2017-0006 Evaluation of Mechanical Ventilator Use with Liquid Oxygen Systems Thomas Blakeman, MSc, RRT; Dario...To) August 2014 – September 2016 4. TITLE AND SUBTITLE Evaluation of Mechanical Ventilator Use with Liquid Oxygen Systems 5a. CONTRACT NUMBER...Cleared, 88PA, Case # 2016-6491, 16 Dec 2016. 14. ABSTRACT Mechanical ventilators coupled with portable liquid oxygen (LOX) systems are critical

  15. The fine art of ‘sourcery’

    CERN Multimedia

    2009-01-01

    The commissioning of the new Linac4 source – first element of the new acceleration chain for the upgrade of the LHC (sLHC) – started at the beginning of July. After years of preparation but after only a few hours of fine-tuning of the numerous parameters involved, the source has delivered its first negative ions. The civil engineering work for the new Linac4 going on near Restaurant 2.While the LHC is preparing for restart, teams of experts involved in the sLHC project are also working on the new facilities that will allow the LHC to run at higher luminosity. The beginning of the new chain of accelerators is Linac4, whose excavation works started October last year. "The particle source that we are commissioning now will be installed at the beginning of the path", explains Maurizio Vretenar, Linac4 project leader. "It is a critical element of the chain as all protons that will circulate in the CERN accelerators will originate from it." The Linac 4 source is differ...

  16. The new building for Linac4 is ready ahead of schedule

    CERN Multimedia

    Francesco Poppi

    2010-01-01

    When various teams work together efficiently to achieve a common goal, not only are projects successfully completed but they may ever be ready before the deadline. On 22 October, after two years of civil engineering work and about two months ahead of schedule, the building that will host the new Linac4 was unveiled in the presence of the Director-General and of Steve Myers, Director for Accelerators and Technology.   Entrance to new Linac 4 tunnel. For the time being, the new two-storey 3000 m2 building looks like a huge empty hangar. Very soon, though, the ground floor will start to be filled with the technical equipment and the klystrons. The Linac4 itself will be installed in the tunnel excavated below the ground. “Being 12 metres underground, deep inside what remains of the old “Mount Citron”, the tunnel provides excellent shielding for the new accelerator”, says Maurizio Vretenar, Linac4 Project Leader. The tunnel will be connected to the PS Booster...

  17. Just a few metres… but the stakes are high

    CERN Multimedia

    Caroline Duc

    2013-01-01

    A beam of negative hydrogen ions has been injected into the first accelerator module of Linac4, the linear accelerator which will replace Linac2.   The Linac4 team celebrate the acceleration of the first beam by the RFQ module. Wednesday, 13 March was a big day for the Linac4 teams. At its temporary location in an old PS hall, the first element in the Linac4 accelerator chain, the Radio Frequency Quadrupole (RFQ) module, accelerated its first beam produced by the new source built for Linac4. This crucial step was a complete success! “Only three metres in length, the RFQ is at the start of the beam's path, immediately after the ion source and the low-energy transport line,” explains Maurizio Vretenar, the Linac4 project leader. “Its job is to increase the beam’s energy from 45 keV to 3 MeV. The section commissioned on Wednesday, which includes the source, the low-energy transport line and the RFQ, is only five metres long but still manages to po...

  18. Deep Red (Profondo Rosso)

    CERN Document Server

    Cine Club

    2015-01-01

    Wednesday 29 April 2015 at 20:00 CERN Council Chamber    Deep Red (Profondo Rosso) Directed by Dario Argento (Italy, 1975) 126 minutes A psychic who can read minds picks up the thoughts of a murderer in the audience and soon becomes a victim. An English pianist gets involved in solving the murders, but finds many of his avenues of inquiry cut off by new murders, and he begins to wonder how the murderer can track his movements so closely. Original version Italian; English subtitles

  19. Los rostros de Ana: Tres comentarios sobre Darío Morales

    Directory of Open Access Journals (Sweden)

    Paul Marcelo Velázquez Sabogal

    2016-03-01

    Full Text Available El presente escrito es una aproximación a la obra del artista colombiano Darío Morales desde la perspectiva dialéctica “vida-muerte”, alentada por el acontecimiento de lo ambiguo y sus implicaciones en la deconstrucción de una corporeidad estable regida por parámetros sociales, jurídicos y biológicos que desembocan en la caracterización de un “otro” en el cual se encuentran figuras como el anormal, el incorregible, el monstruo. Desde ellos pretendo trazar un punto de vista sobre aquellos Rostros de Ana donde se manifiestan figuras como el onanista y la vampira, para desembocar en un comentario que amplíe el espectro de sentido alrededor la obra del artista cartagenero. Palabras claves Cuerpo ambiguo, vida-muerte, sagrado-profano, onanismo. Ñawekuna kai warmi Ana Sutipa: Kimsa pariai ksi runa Dario Morales Sugllapi Kai kilkai kame ñalla regcha kai tacha runa colombiano Dario Morales Kilkakasina rimangapa “ kausai- wamui” aida chingapa kaikuna Mana allilla llugsichu tukuikunamanda icharichu llanga “sug manda” Kaipe turrerreme ¡ kauancheme man aillakaska, man allilla rurasla! Kirú. Kaipi pudenchi kauanga imasami kauacheca kai warme Ana paipa ñawekuna Kai ruraikuna sutikame onanista Chasallata vampira, Kaiwa munakume Allilla intendechengapa imasame parlaku sug iacha Cartagenero. Ima suti Rimai Simi: Cuerpo ambiguo, kaugsai, muerte, sagrado - profano, onanismo. The Faces of Ana: Three Comments on Dario Morales Abstract This paper is an approach to the work of Colombian artist Dario Morales from the perspective of the dialectic of “life and death”, encouraged by the occurrence of the ambiguous and its implications for the deconstruction of a stable corporeality governed by social, legal and biological parameters that lead to the characterization of an “other”, in which figures such as the abnormal, the incorrigible, the monster are to be found. From them, I intend to plot a point of view on those faces of Ana

  20. Unusually Gothic : Robert Sigl's Laurin (1987)

    OpenAIRE

    Stiglegger, Marcus

    2010-01-01

    Marcus Stiglegger revives a lost Gothic treasure in this brief discussion of Robert Sigl's Laurin—a rare case of German genre film-making and the heir to FW Murnau's legacy. Phantastic genre cinema is very rare in contemporary Germany—especially in the 1980s, the time when Italian horror reached another peak with Dario Argento's Opera (1985). The cliché of the German "easy comedy" ruled mainstream film production at the time, and so it appeared a kind of miracle when 27-year-old writer/direct...

  1. Nanomedicine in diagnostics

    CERN Document Server

    Rozlosnik, Noemi

    2012-01-01

    Biased Diffusion and Rectified Brownian Motion at the Nanoscale Driving Mobile Sensing Automata for the Early Diagnosis of Endogenous DiseasesDario Narducci and Gianfranco CerofoliniBiotechnology-Utilized Nanopore for Single-Molecule InvestigationJi Wook Shim and Li-Qun GuSelf-assembled Peptide and Protein Nanostructures in DiagnosisJaime Castillo-León, Yuri Belotti, and Winnie E. SvendsenElectrochemical Sensor Systems for MedicineV. V. Shumyantseva, E. V. Suprun, T. V. Bulko, Ya. M. Chalenko, and A. I. ArchakovCon

  2. Pervivencias ind??genas en el arte novohispano: una propuesta de estudio

    OpenAIRE

    2016-01-01

    Con la conquista de lo que habr??a de ser la Nueva Espa??a y el consiguiente desman??telamiento de los par??metros culturales que durante milenios hab??an regido en Mesoam??rica, se produce una fractura entorno a la cual, y cualquiera que sea el campo de nuestro an??lisis, parece delimitarse un antes y un despu??s perfectamente ubicados. En el arte novohispano las pervivencias ind??genas se manifiestan en lugares secun??darios y en detalles pues, como es obvio, el programa iconogr??fico y...

  3. DESARROLLO DE LA VARIANTE CAMBIAL EN SERJANIA MERIDIONALIS (SAPINDACEAE, PAULLINIEAE

    Directory of Open Access Journals (Sweden)

    M. Lucía Borniego

    2014-01-01

    Full Text Available La familia Sapindaceae representa uno de los grupos de plantas trepadoras más importante del Neo - trópico y presenta diversas variantes cambiales, algunas exclusivas. En esta contribución se describe el desarrollo del leño de Serjania meridionalis , la especie más austral del género, estudiado mediante técnicas anatómicas convencionales sobre la base de material proveniente de Isla Martín García (Buenos Aires, Argentina. El sistema vascular primario es eustélico. El crecimiento secundario se inicia con un cambium típico; sin embargo, con posterioridad, se desdiferencian meristemas de engrosamiento secun - dario supernumerarios. Estos meristemas producen nuevos cilindros vasculares (xilema y floema secun - darios en la periferia del cilindro vascular original. La presencia de cilindros vasculares cordados en los tallos añosos de S. meridionalis es novedad para la especie y plantea la necesidad de rever la dicotomía presencia-ausencia de variantes cambiales en muchas claves de identificación.

  4. Cine club

    CERN Multimedia

    Ciné club

    2015-01-01

    Wednesday 15 April 2015 at 20:00CERN Council Chamber The Cat o’ Nine Tails (Il gatto a nove code) Directed by Dario Argento (Italy, 1971) 112 minutes   Franco Arno is a blind man that lives with his young niece and makes a living writing crossword puzzles. One night, while walking on the street, he overhears a weird conversation between two men sitting in a car parked in front of a medical institute where genetic experiments are performed. The same night someone breaks in the institute and knocks out a guard. Arno decides to investigate with the help of reporter Carlo Giordani. Original version Italian; English subtitles   Wednesday 22 April 2015 at 20:00CERN Council Chamber Four Flies on Grey Velvet (4 mosche di velluto grigio) Directed by Dario Argento (Italy, 1971) 104 minutes Roberto, a drummer in a rock band, keeps receiving weird phone calls and being followed by a mysterious man. One night he manages to catch up with his persecutor and tries to get him to t...

  5. Tudengiteatrite vaim ja vaev / Rait Avestik

    Index Scriptorium Estoniae

    Avestik, Rait, 1974-

    2006-01-01

    17.-19. veebr. Viljandis toimunud üliõpilasteatrite festivalist, millest võtsid osa Tartu Üliõpilasteater : S. Kane "Puhastatud", lavastaja Kalev Kudu ; TÜ Pärnu kolledži üliõpilasteater K-äng2 : kohvikuprogramm "Maailma lõpus on kohvik" ; TÜ Viljandi Kultuuriakadeemia üliõpilased (mitte näitlejasuuna õppurid) : lavaline kompositsioon "Actus interruptus" ; Tallinna Tehnikaülikooli T-teater : Kurt Wonneguti "Õnne sünnipäevaks, Wanda June!", lavastaja Tamur Tohver ning Tallinna Ülikooli Üliõpilasteater : John Boynton Priestley "Nad tulid linna", lavastaja Juta Terali. Eraldi vaadeldakse TÜ Viljandi Kultuuriakadeemia 3. kursuse näitekunsti tudengite tööd : Dario Fo "Müsteerium Buff", lavastaja Peeter Raudsepp

  6. The cultural policy in Italy and the innovations of the XXI century

    Directory of Open Access Journals (Sweden)

    Olimpia Niglio

    2016-05-01

    Full Text Available The paper analyzes the development of the first experiences of the sixteenth century cultural policy in Italy until the beginning of the twenty-first century with the institutional reform initiated by the Minister Dario Franceschini. In the pre-unification State it has been many important contributions of several local rulers who imposed conservation policies to prevent the dispersal of works of art. After the unification of Italy (1861 the laws of protection of the national heritage have helped to initiate the first important initiatives that have developed in practice only at the end of the twentieth century. Great institutional innovations and regulatory activated in the twenty-first century and of which this paper provides some important insights and deepening.

  7. Tudengiteatrite vaim ja vaev / Rait Avestik

    Index Scriptorium Estoniae

    Avestik, Rait, 1974-

    2006-01-01

    17.-19. veebr. Viljandis toimunud üliõpilasteatrite festivalist, millest võtsid osa Tartu Üliõpilasteater : S. Kane "Puhastatud", lavastaja Kalev Kudu ; TÜ Pärnu kolledži üliõpilasteater K-äng2 : kohvikuprogramm "Maailma lõpus on kohvik" ; TÜ Viljandi Kultuuriakadeemia üliõpilased (mitte näitlejasuuna õppurid) : lavaline kompositsioon "Actus interruptus" ; Tallinna Tehnikaülikooli T-teater : Kurt Wonneguti "Õnne sünnipäevaks, Wanda June!", lavastaja Tamur Tohver ning Tallinna Ülikooli Üliõpilasteater : John Boynton Priestley "Nad tulid linna", lavastaja Juta Terali. Eraldi vaadeldakse TÜ Viljandi Kultuuriakadeemia 3. kursuse näitekunsti tudengite tööd : Dario Fo "Müsteerium Buff", lavastaja Peeter Raudsepp

  8. Touching base with OPERA

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    Three seminars – at CERN, at Gran Sasso and in Japan – and an article calling for the scrutiny of the scientific community: the OPERA Collaboration opened its research publicly. In addition to huge press coverage, this triggered welcome reactions from colleagues around the world, many of whom will attempt to independently interpret and reproduce the measurement. OPERA’s Spokesperson touches base with the Bulletin.   The CERN Main Auditorium was crowded as OPERA Physics co-ordinator Dario Autiero presented the results of their research (23 September 2011). According to the OPERA strategy, the results of the measurements are in the hands of the scientific community and, as for any other scientific result, several months will be needed before other groups will be able to perform an independent measurement. In the meantime, the OPERA Collaboration is dealing with an avalanche of emails from the scientific community, members of the general public, and the press. &...

  9. New ATLAS Software & Computing Organization

    CERN Multimedia

    Barberis, D

    Following the election by the ATLAS Collaboration Board of Dario Barberis (Genoa University/INFN) as Computing Coordinator and David Quarrie (LBNL) as Software Project Leader, it was considered necessary to modify the organization of the ATLAS Software & Computing ("S&C") project. The new organization is based upon the following principles: separation of the responsibilities for computing management from those of software development, with the appointment of a Computing Coordinator and a Software Project Leader who are both members of the Executive Board; hierarchical structure of responsibilities and reporting lines; coordination at all levels between TDAQ, S&C and Physics working groups; integration of the subdetector software development groups with the central S&C organization. A schematic diagram of the new organization can be seen in Fig.1. Figure 1: new ATLAS Software & Computing organization. Two Management Boards will help the Computing Coordinator and the Software Project...

  10. El Hombre, un ser integral

    Directory of Open Access Journals (Sweden)

    Gabriel Alexander Solórzano

    2008-12-01

    Full Text Available El artículo pretende mostrar la dificultad que existe al momento de elaborar una precisa definición del hombre como ser integral, para ello se recurre a las nociones esenciales de la antropología filosófica, la nueva concepción del giro cristia- no de la fenomenología francesa, se mira grosso modo la visión personalista de Juan Pablo II sobre el hombre y la visión integradora de Panikkar del humanismo cosmote- ándrico, por último se encuentra la visión del humanismo cristiano y el desarrollo soli- dario enfatizado en el Magisterio de la Iglesia Católica como intento de respuesta a la crucial pregunta sobre el hombre y su mundo relacional. Palabras clave: Filosofía, Teología moral, Fenomenología, Humanismo, Perso- nalismo, Cosmoteándrico. 

  11. Canakinumab as rescue therapy in familial Mediterranean fever refractory to conventional treatment

    Directory of Open Access Journals (Sweden)

    Alpa M

    2015-04-01

    Full Text Available Mirella Alpa, Dario Roccatello Centro di Ricerche di Immunopatologia e Documentazione su Malattie Rare (CMID, Struttura Complessa Direzione Universitaria di Immunologia Clinica, Università di Torino e Ospedale G Bosco, Torino, ItalyAbstract: Familial Mediterranean fever is an autosomal recessive autoinflammatory disorder mainly affecting Mediterranean populations, which is associated with mutations of the MEFV gene that encodes pyrin. Functional studies suggest that pyrin is implicated in the maturation and secretion of interleukin-1 (IL-1. The IL-1 receptor antagonist or anti-IL-1 monoclonal antibody may therefore represent a rational approach for the treatment of the rare patients who are refractory to conventional therapy. We report the case of a young female affected by familial Mediterranean fever who proved to be resistant to colchicine and was successfully treated with canakinumab.Keyword: interleukin-1, colchicine, familial Mediterranean fever, anti-IL-1 treatment, biologic agents

  12. Perioperative management of facial bipartition surgery

    Directory of Open Access Journals (Sweden)

    Caruselli M

    2015-11-01

    Full Text Available Marco Caruselli,1 Michael Tsapis,1,2 Fabrice Ughetto,1 Gregoire Pech-Gourg,3 Dario Galante,4 Olivier Paut1 1Anesthesia and Intensive Care Unit, La Timone Children’s Hospital, 2Pediatric Transport Team, SAMU 13, La Timone Hospital, 3Pediatric Neurosurgery Unit, La Timone Children’s Hospital, Marseille, France; 4Anesthesia and Intensive Care Unit, University Hospital Ospedali Riuniti of Foggia, Foggia, Italy Abstract: Severe craniofacial malformations, such as Crouzon, Apert, Saethre-Chotzen, and Pfeiffer syndromes, are very rare conditions (one in 50,000/100,000 live births that often require corrective surgery. Facial bipartition is the more radical corrective surgery. It is a high-risk intervention and needs complex perioperative management and a multidisciplinary approach. Keywords: craniofacial surgery, facial bipartition surgery, craniofacial malformations, pediatric anesthesia

  13. Itinerarios textuales del "Quijote" en América (siglos XVII a XIX

    Directory of Open Access Journals (Sweden)

    Eva Marìa Valero Juan

    2013-12-01

    Full Text Available Starting with a brief description of the journey taken by the first editions of the Quixote which were sent to America, this article aims to review the textual biography of don Quixote in America between the 17th and 19th centuries. This selective review starts with the accounts of popular festivities that give evidence of the first appearances of don Quixote and Sancho in the texts. The selection of texts goes from 1607 to the Spanish Emancipation century, paying particular attention to its final years, with the analysis of some of the texts that Ruben Dario devoted to the Quixote, and of the rise of Don Quixote as a Spanish American symbol of identity.

  14. “Les non-dupes errent”. Pensiero debole e politica

    Directory of Open Access Journals (Sweden)

    Andrea Muni

    2014-06-01

    Full Text Available The aim of the paper is to suggest a new ethical and individual form of political resistance. After a review of DarioGentili’s book "Italian theory. Dall’operaismo alla biopolitica", the essay retraces in its first part the political genealogy of the italian philosophical trend called “pensiero debole”, comparing it besides with the political and philosophical season of post-operaism. This comparison focuses in particular on the relation between the different positions of Pier Aldo Rovatti and Antonio Negri during the Seventies and the early Eighties. The second part of the essay expands some of the main philosophical themes of Rovatti’s “pensiero debole”, concentrating especially on the political aspects of Jacques Lacan’s and Michel Foucault’s thought. The philosophical question of the subject, according to the thought of the named authors, emerges at the end of the paper in its very political dimension.

  15. UNA VOZ QUE CANTA AL SER HUMANO: AMADO NERVO

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    María Elena González

    2014-05-01

    Full Text Available The objective of the present study is to analyze two poems by the author Amado Nervo. Amado Nervo was a Mexican poet. He was born on August 27, 1870 in the city of Tepic, Nayarit, and died on May 24, 1919. This Mexican author was, storyteller, essayist, Professor, reporter and diplomat is a worthy representative of the Latin American poetry. More specifically in the genre of modernist, because he was in contact with various poets of this trend, such as: Leopoldo Lugones, and Dario Rubén, his work has three well representative moments, marked by his experiences. This analysis aims to give an account of how the poet gradually abandons modernism, which is the literary movement where it was inserted at the beginning of his work, and you are entering poems exalting the spirituality of the human being.

  16. Diavolo di una particella perchè il bosone di Higgs cambierà la nostra vita

    CERN Document Server

    Menasce, Dario

    2013-01-01

    Lo scienziato del Cern Dario Menasce ha partecipato direttamente agli esperimenti che hanno condotto alla scoperta del Bosone di Higgs, ma , prima di condurre il lettore all'interno dell'LHC e dei suoi misteri, con coinvolgimento e grande serietà guida il lettore attraverso i momenti più importanti delle ricerche della fisica tramite l'intervento dei grandi scienziati del passato e del presente, che hanno infine permesso di arrivare a definire il Modello Standard delle particelle, il primo passo verso l'ipotetica Teoria del Tutto. Un testo molto utile per chi vuole sondare il mondo dell'ultrasottile, che riprendo in più occasioni anche come manuale di consultazione e approfondimento.

  17. Section Editors

    Science.gov (United States)

    Groep, D. L.; Bonacorsi, D.

    2014-06-01

    1. Data Acquisition, Trigger and Controls Niko NeufeldCERNniko.neufeld@cern.ch Tassos BeliasDemokritosbelias@inp.demokritos.gr Andrew NormanFNALanorman@fnal.gov Vivian O'DellFNALodell@fnal.gov 2. Event Processing, Simulation and Analysis Rolf SeusterTRIUMFseuster@cern.ch Florian UhligGSIf.uhlig@gsi.de Lorenzo MonetaCERNLorenzo.Moneta@cern.ch Pete ElmerPrincetonpeter.elmer@cern.ch 3. Distributed Processing and Data Handling Nurcan OzturkU Texas Arlingtonnurcan@uta.edu Stefan RoiserCERNstefan.roiser@cern.ch Robert IllingworthFNAL Davide SalomoniINFN CNAFDavide.Salomoni@cnaf.infn.it Jeff TemplonNikheftemplon@nikhef.nl 4. Data Stores, Data Bases, and Storage Systems David LangeLLNLlange6@llnl.gov Wahid BhimjiU Edinburghwbhimji@staffmail.ed.ac.uk Dario BarberisGenovaDario.Barberis@cern.ch Patrick FuhrmannDESYpatrick.fuhrmann@desy.de Igor MandrichenkoFNALivm@fnal.gov Mark van de SandenSURF SARA sanden@sara.nl 5. Software Engineering, Parallelism & Multi-Core Solveig AlbrandLPSC/IN2P3solveig.albrand@lpsc.in2p3.fr Francesco GiacominiINFN CNAFfrancesco.giacomini@cnaf.infn.it Liz SextonFNALsexton@fnal.gov Benedikt HegnerCERNbenedikt.hegner@cern.ch Simon PattonLBNLSJPatton@lbl.gov Jim KowalkowskiFNAL jbk@fnal.gov 6. Facilities, Infrastructures, Networking and Collaborative Tools Maria GironeCERNMaria.Girone@cern.ch Ian CollierSTFC RALian.collier@stfc.ac.uk Burt HolzmanFNALburt@fnal.gov Brian Bockelman U Nebraskabbockelm@cse.unl.edu Alessandro de SalvoRoma 1Alessandro.DeSalvo@ROMA1.INFN.IT Helge MeinhardCERN Helge.Meinhard@cern.ch Ray PasetesFNAL rayp@fnal.gov Steven GoldfarbU Michigan Steven.Goldfarb@cern.ch

  18. Atti del convegno "Questioni di storia inglese tra Cinque e Seicento: cultura, politica e religione", (Scuola Normale Superiore di Pisa, 11-12 aprile 2002, a cura di Stefano Villani, Stefania Tutino, Chiara Franceschini.

    Directory of Open Access Journals (Sweden)

    Stefano Villani

    2003-01-01

    Full Text Available Mario Rosa, Introduzione. Paolo Cristofolini, Ricordo di un amico. Daniela Bianchi, L'intero libro di Dio, chiamato Bibbia. Alle origini dell'identità puritana. Ginevra Crosignani, Thomas Wright, i suoi scritti ritrovati e il dibattito con Robert Parsons, S. J., sulla partecipazione al servizio e al sermone anglicano. Stefania Tutino, Thomas Pounde, Andrew Willet e la questione cattolica all'inizio del regno di Giacomo I. Chiara Franceschini, Nostalgie di un esule. Note su Giacomo Castelvetro (1546-1616. Eleonora Belligni, Marcantonio De Dominis tra l'Inquisizione romana e Giacomo I: nuove prospettive storiografiche dopo Cantimori. Mauro Simonazzi, La melanconia nell'Inghilterra moderna: Edward Jorden, Timothie Bright e Thomas Adams. Mario Caricchio, Giles Calvert, un "editore d'area" nella rivoluzione inglese. Stefano Villani, "Una piccola epitome di Inghilterra". La comunità inglese di Livorno negli anni di Ferdinando II: questioni religiose e politiche. Luisa Simonutti, William Popple e William Penn. Dalla libertà di coscienza alle libertà civili. Giovanni Tarantino, Libertà di coscienza, 'aritmetica politica' e interesse nazionale: le ragioni economiche della tolleranza nel regno di Giacomo II Stuart. Guglielmo Sanna, Contrattualismo e obbedienza politica nella cultura anglicana degli inizi del Settecento. Dario Pfanner, Charles Blount (1654-1693: la voce di un libero pensatore nella Londra di fine Seicento. Tomaso Cavallo, Aggressore dell'umanità e apologeta della tirannide? L'Hobbes degli enciclopedisti.

  19. Effectiveness of cognitive behavioral therapy integrated with systematic desensitization, cognitive behavioral therapy combined with eye movement desensitization and reprocess­ing therapy, and cognitive behavioral therapy combined with virtual reality exposure therapy methods in the treatment of flight anxiety: a randomized trial

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    Triscari MT

    2015-10-01

    Full Text Available Maria Teresa Triscari,1 Palmira Faraci,2 Dario Catalisano,3 Valerio D’Angelo,1 Viviana Urso1 1Laboratory for Psychosomatic Disorders, Local Health Trust, Palermo, Italy; 2Faculty of Human and Social Sciences, University of Enna “Kore”, Enna, Italy; 3Italian Flight Safety Committee, Aeroporto di Fiumicino, Fiumicino (RM, Italy Abstract: The purpose of the research was to compare the effectiveness of the following treatment methods for fear of flying: cognitive behavioral therapy (CBT integrated with systematic desensitization, CBT combined with eye movement desensitization and reprocessing therapy, and CBT combined with virtual reality exposure therapy. Overall, our findings have proven the efficacy of all interventions in reducing fear of flying in a pre- to post-treatment comparison. All groups showed a decrease in flight anxiety, suggesting the efficiency of all three treatments in reducing self-report measures of fear of flying. In particular, our results indicated significant improvements for the treated patients using all the treatment programs, as shown not only by test scores but also by participation in the post-treatment flight. Nevertheless, outcome measures maintained a significant effect at a 1-year follow-up. In conclusion, combining CBT with both the application of eye movement desensitization and reprocessing treatment and the virtual stimuli used to expose patients with aerophobia seemed as efficient as traditional cognitive behavioral treatments integrated with systematic desensitization. Keywords: flight anxiety, fear of flying, aerophobia, cognitive behavioral therapy, EMDR, VRET 

  20. CERN and the 10,000th application of the WorldFIP protocol

    CERN Multimedia

    2001-01-01

    On 24 April, CERN received an award for the 10,000th application of the WorldFIP industrial communication network protocol. The award was presented to Juan Antonio Rubio, Head of CERN's ETT Division, by Marc Desjardins, President of the WorldFIP association, which groups together 430 industrial partners with the aim of promoting the WorldFIP concept. Marc Desjardins, President of the WorldFIP association, presenting the award for the 10,000th application to CERN ETT Division Leader Juan Antonio Rubio. From left to right: Guy Baribaud (CERN), Ercole Gallacio (WF), Noël Fayard (WF), Gérard Demars (WF), Dario Fantoni (WF), Marc Desjardins (WF), Raymond Brun (CERN), Jean-Pierre Hauet (WF), Juan Antonio Rubio (CERN), Bernard Jouga (WF), Raymond Rausch (CERN), Jean-Pierre Froidevaux (WF), Marilena Streit-Bianchi (CERN), Michel Rabany (CERN), Patrick Chatelet (WF), Nicolas Cravoisy (WF), Jean Bergeal (WF). Communication networks, also known as fieldbuses, provide for digital comunication betwe...

  1. Camilo Torres remembered on the eve of the fifty anniversary of his death

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    François Houtart

    2016-04-01

    Full Text Available A highly symbolic act took place in Cali on 7 November by initiative of Monsignor Dario Monsalve Jesus Mejia, archbishop of that city, the third of Colombia: The memory of Camilo Torres Restrepo as a Christian and as a priest. To prepare for the event, Archbishop had written in a magazine of the Archdiocese entitled I Camilo yesterday and today, a sign of reconciliation (Notebooks citizens - Observatory of social realities, number 5, November 2015, p. 8: “The priest Camilo Torres Restrepo, subject to their mortal remains to secret State.1 in the influence of his Christian thought, the silence of the Church and the guerrilla stigma on his name, has a lot to give and teach a Colombia that is projected towards reconciliation, the truth, transitional justice and peace

  2. España-América Latina (1900-1940: la consolidación de una solidaridad

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    Abellán, José Luis

    2007-04-01

    Full Text Available Between 1892 —IVth Centennial of the Discovery of America- and 1912 - Ist Centennial of the Cadiz Constitution— a number of meetings take place among intellectuals from both sides of the Atlantic. Gathered together by Modernist approachs, they promote solidarity and regeneration initiatives between Spain and Latin America around the concept of Hispanidad. People like Rubén Darío, Alfonso Reyes, Rafael Altamira and Miguel de Unamuno create solid platforms for these approaching efforts —Junta para Ampliación de Estudios, Ateneo de la Juventud, Institución Cultural Española— where Science occupies a privileged position.

    Entre 1892, con la celebración del IV Centenario del Descubrimiento de América, y 1912, con ocasión del I Centenario de la Constitución de Cádiz, ocurren una serie de encuentros entre intelectuales de una y otra parte del Atlántico que compartiendo los planteamientos del modernismo promueven iniciativas de solidaridad y de regeneración entre España y América Latina, que se aglutinan en torno al concepto de hispanidad. Nombres como Rubén Dario, Alfonso Reyes, Rafael Altamira y Miguel de Unamuno crean sólidas plataformas de acercamiento: Junta para Ampliación de Estudios, Ateneo de la Juventud, Institución Cultural Española, donde la ciencia ocupa un lugar privilegiado.

  3. Overview of diagnostic/targeted treatment combinations in personalized medicine for breast cancer patients

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    Tessari A

    2013-12-01

    Full Text Available Anna Tessari,1 Dario Palmieri,2 Serena Di Cosimo11Division of Medical Oncology 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; 2Molecular Biology and Cancer Genetics, Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, USAAbstract: Breast cancer includes a body of molecularly distinct subgroups, characterized by different presentation, prognosis, and sensitivity to treatments. Significant advances in our understanding of the complex architecture of this pathology have been achieved in the last few decades, thanks to new biotechnologies that have recently come into the research field and the clinical practice, giving oncologists new instruments that are based on biomarkers and allowing them to set up a personalized approach for each individual patient. Here we review the main treatments available or in preclinical development, the biomolecular diagnostic and prognostic approaches that changed our perspective about breast cancer, giving an overview of targeted therapies that represent the current standard of care for these patients. Finally, we report some examples of how new technologies in clinical practice can set in motion the development of new drugs.Keywords: breast cancer, biomarkers, gene expression profile, next generation sequencing, targeted therapy

  4. MEchatronic REspiratory System SImulator for Neonatal Applications (MERESSINA project: a novel bioengineering goal

    Directory of Open Access Journals (Sweden)

    Scaramuzzo RT

    2013-08-01

    Full Text Available Rosa T Scaramuzzo,1,2 Massimiliano Ciantelli,1 Ilaria Baldoli,3 Lisa Bellanti,3 Marzia Gentile,1 Francesca Cecchi,3 Emilio Sigali,1 Selene Tognarelli,3 Paolo Ghirri,1–4 Stefano Mazzoleni,3 Arianna Menciassi,3 Armando Cuttano,1 Antonio Boldrini,1–4 Cecilia Laschi,3 Paolo Dario3 1Centro di Formazione e Simulazione Neonatale "NINA," UO Neonatologia, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy; 2Istituto di Scienze della Vita, 3The BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, Italy; 4Università di Pisa, Pisa, Italy Abstract: Respiratory function is mandatory for extrauterine life, but is sometimes impaired in newborns due to prematurity, congenital malformations, or acquired pathologies. Mechanical ventilation is standard care, but long-term complications, such as bronchopulmonary dysplasia, are still largely reported. Therefore, continuous medical education is mandatory to correctly manage devices for assistance. Commercially available breathing function simulators are rarely suitable for the anatomical and physiological realities. The aim of this study is to develop a high-fidelity mechatronic simulator of neonatal airways and lungs for staff training and mechanical ventilator testing. The project is divided into three different phases: (1 a review study on respiratory physiology and pathophysiology and on already available single and multi-compartment models; (2 the prototyping phase; and (3 the on-field system validation. Keywords: simulation, lung, newborn, continuous medical education, respiratory system

  5. U Tingiutu. Ajax in Calabria. Political Fissures in the Theatre of Scena Verticale

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    Angela Albanese

    2015-11-01

    Full Text Available The curse of Calabria is collusion. Collusion between the law of the state and the hidden law, between the power of public institutions and mafia power, between upright citizens and "la mala carne", the "evil flesh" of the criminal underworld. Director, actor and playwright Dario De Luca, guiding spirit with Saverio La Ruina of the Scena Verticale theatre company, shines a light on the criminal state within the state in his new play, U Tingiutu. Ajax in Calabria, in which he also performs along with four other actors. De Luca has transformed Sophocles's tragedy to illuminate the daily tragedy of gang warfare, street killings, and blood spilled in the name of honor, in the face of the cowardly inertia of those who pretend not to see. De Luca's Calabria is beseiged by 'ndrangheta power and drained by an ineffectual, often complicit political sector, its social fabric muddied and torn. The dynamics by which mafia violence insinuates itself into the shadowy corners of politics to seize control of the law are acutely revealed in the shadow zones of language, in the harsh, archaic dialect of the region, full of allusion, meaningful silence and glances.

  6. Barrera del desempeño laboral

    Directory of Open Access Journals (Sweden)

    María Del Rosario Alvarez-Ramirez

    2007-12-01

    Full Text Available El estres es un hecho complejo en la vida de toda persona con efectos distintos en cada quien, que no puede ser evitada ya que en todos lo momentos de la vida se esta en riesgo de presentarlo ante cualquier situacion, o una actividad laboral o familiar, que puede llegar a generar cualquier cambio que represente estres. Los sucesos negativos, dario, enfermedad o muerte de un ser querido, son hechos estresantes, asi como los sucesos positivos; ascender en el trabajo trae consigo el estres del nuevo status, de nuevas responsabilidades. Dentro de los trastornos clinicos vinculados al estres hay alteraciones como: trastornos del sumo, ulceras, dolores de cabeza, aceleracion del ritmo cardiaco y otros trastornos como los cardiovasculares: palpitaciones, hipertension arterial, trastornos digestivos, dolores, ardores, vomitos, nauseas, diarrea o estreriimiento y trastornos cutaneos: donde se presenta transpiracion de manos y pies y problemas alergicos. En el estres se pueden llegar a presentar dos tipos de estres: el positivo y el negativo. Los cuales presentan unas caracteristicas muy particulares, como en el estres negativo: una persona se encuentra ante un nitmero creciente de demandas que le plantean dificultad o constituyen una amenaza, se debe mirar el modo de afrontarlas. En el Estres positivo se presenta cuando la percepcion de capacidad de demanda es mucho mas amplia que las verdaderas demandas. Un aspecto fundamental ante la presencia de estres es la practica necesaria de un deporte o la realizacion de actividades recreativas.

  7. Academic Training Lectures | Representing Scientific Communities by Data Visualization | 14-15 March

    CERN Multimedia

    2016-01-01

    Please note that the next series of Academic Training Lectures will take place from 14 to 15 March 2016 and will be given by Dario Rodighiero (EPFL, Lausanne, Switzerland).   Representing Scientific Communities by Data Visualisation (1/2)​ Monday, 14 March 2016 from 11 a.m. to 12 p.m. https://indico.cern.ch/event/465533/ Representing Scientific Communities by Data Visualisation (2/2)​ Tuesday, 15 March 2016 from 11 a.m. to 12 p.m. https://indico.cern.ch/event/465534/ at CERN, IT Amphitheatre (31-3-004)  Description: These lectures present research that investigates the representation of communities, and the way to foster their understanding by different audiences. Communities are complex multidimensional entities intrinsically difficult to represent synthetically. The way to represent them is likely to differ depending on the audience considered: governi...

  8. Gothic/Giallo/Genre: hybrid images in Italian horror cinema, 1956-82

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    Keith H Brown

    2012-11-01

    Full Text Available http://dx.doi.org/10.5007/2175-8026.2012n62p173   Italian horror cinema is commonly divided into two periods and genres. An initial classical Gothic period spanned the years from 1956 to 1966 and was followed by a modern giallo (thriller period from 1970 to 1982. Whilst accepting this broad distinction, this paper seeks to add nuance by considering the hybrid elements of three key films by three of the most important directors working in the giallo and horror area, namely Riccardo Freda with I Vampiri (1956, Mario Bava with The Girl Who Knew too Much (1963 and Dario Argento with Deep Red (1975. Drawing in particular upon Nöel Carroll’s idea of “fearing fictions”, I contend that Freda’s film, the first Italian horror movie since the silent era, is notable for being a distinctively modern vampire film; that Bava’s film, a foundational giallo, may be seen as having a palimpsest in Jane Austen’s Gothic parody Northanger Abbey; and that Argento’s film, while often taken as the paradigmatic giallo, has supernatural horror elements that push it in the direction of the Gothic.

  9. Recent advances in the development of breast cancer vaccines

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    Milani A

    2014-10-01

    Full Text Available Andrea Milani,1 Dario Sangiolo,1 Massimo Aglietta,1,2 Giorgio Valabrega1,2 1Department of Oncology, University of Torino, Torino, Italy; 2FPO, Candiolo Cancer Institute, IRCCS, Torino, Italy Abstract: The manipulation of the immune system through the administration of a vaccine to direct an effective and long-lasting immune response against breast cancer (BC cells is an attractive strategy. Vaccines would have several theoretical advantages over standard therapies, including low toxicities, high specificity, and long-lasting efficacy due to the establishment of immunological memory. However, BC vaccines have failed to demonstrate meaningful results in clinical trials so far. This reflects the intrinsic difficulty in breaking the complex immune-escaping mechanisms developed by cancer cells. New vaccines should be able to elicit complex immunologic response involving multiple immune effectors such as cytotoxic and antibody-secreting B cells, innate immunity effectors, and memory cells. Moreover, especially in patients with large tumor burdens and metastatic disease, combining vaccines with other strategies, such as systemic BC therapies, passive immunotherapy, or immunomodulatory agents, could increase the effectiveness of each approach. Here, we review recent advances in BC vaccines, focusing on suitable targets and innovative strategies. We report results of most recent trials investigating active immunotherapy in BC and provide possible future perspectives in this field of research. Keywords: breast cancer, cancer vaccines, cancer immunology, HER2, MUC-1, hTERT

  10. Long term efficacy and safety of etanercept in the treatment of psoriasis and psoriatic arthritis

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    Kivelevitch D

    2014-04-01

    Full Text Available Dario Kivelevitch, Bobbak Mansouri, Alan Menter Department of Dermatology, Baylor University Medical Center, Dallas, TX, USA Abstract: Psoriasis is a chronic, immune-mediated inflammatory disease affecting both the skin and joints. Approximately 20% of patients suffer a moderate to severe form of skin disease and up to 30% have joint involvement. Standard therapies for psoriasis include topical medications, phototherapy, and both oral systemic and biological therapies whereas therapies for psoriatic arthritis include nonsteroidal anti-inflammatory drugs followed by disease modifying antirheumatic drugs and/or tumor necrosis factor (TNF-α inhibitors and interleukin-12/23p40 inhibitors. Treatment of both diseases is typically driven by disease severity. In the past decade, major advances in the understanding of the immunopathogenesis of psoriasis and psoriatic arthritis have led to the development of numerous biological therapies, which have revolutionized the treatment for moderate to severe plaque psoriasis and psoriatic arthritis. Anti-TNF-α agents are currently considered as first line biological therapies for the treatment of moderate to severe psoriasis and psoriatic arthritis. Currently approved anti-TNF-α agents include etanercept, adalimumab, and infliximab for psoriasis and psoriatic arthritis as well as golimumab and certolizumab for psoriatic arthritis. In this article, we aim to evaluate the long term safety and efficacy of etanercept in psoriasis and psoriatic arthritis. Keywords: psoriasis, psoriatic arthritis, etanercept, biological therapy, tumor necrosis factor, safety

  11. Temperature behaviour of photo-emissive films. The case of photo-multipliers used in scintillation counters; Comportement en temperature des couches photoemissives. Cas des photomultiplicateurs utilises dans les compteurs a scintillations

    Energy Technology Data Exchange (ETDEWEB)

    Ardalan, A.H. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1966-07-01

    This work concerns the changes in the spectral sensitivity of 3 types of normal photo-cathodes (Cs{sub 3}Sb, tri-alkali and bi-alkali without cesium) as a function of temperature. The photo-cathodes of cathodes of commercial photomultipliers (DARIO, E.M.I., R.C.A., A.S.C.O.F.) were used for these tests. The temperature range studied was -25 C to +55 C (except for the bi-alkali photo-cathodes which were tested up to +150 C) and the wave-length range was 3250 to 7000 angstrom. After a brief review of photo-electric effect theories, the experimental device is described and the measurement results presented. Finally, an interpretation of these results is proposed. For the normal range of scintillator emission, i.e. between 3000 and 5000 angstroms (Na I (Tl), plastics, anthracene) the temperature coefficient is always negative: -0.15 % C for Cs{sub 3}Sb and up to -0.5 % C for the most temperature-sensitive photo-cathode. Above 5000 angstrom, the temperature coefficient of Cs{sub 3}Sb films becomes positive: +0.5 % C on the overage. The accuracy of the spectral sensitivity measurements is {+-}4 % in absolute value and {+-}1 % in relative value. (author) [French] Cette etude porte sur la variation de la sensibilite spectrale de 3 types de photocathodes usuelles (Cs{sub 3}Sb, trialcalines et bialcalines sans cesium) en fonction de la temperature. Des photocathodes de photomultiplicateurs du commerce (DARIO, E.M.I., R.C.A., A.S.C.O.P.) ont fait l'objet de ces essais. Le domaine examine s'etendait en temperature de -25 C a +55 C (sauf pour les photocathodes bialcalines qui ont ete portees a une temperature de +150 C) et en longueur d'onde de 3250 a 7000 angstrom. Apres un rappel des theories de l'effet photoelectrique, le dispositif experimental est decrit et les resultats des mesures exposes. Enfin, une interpretation de ces resultats est proposee. Dans le domaine de l'emission des scintillateurs usuels, c'est-a-dire entre 3000 et 5000 angstrom

  12. New developments in prosthetic arm systems

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    Vujaklija I

    2016-07-01

    Full Text Available Ivan Vujaklija,1 Dario Farina,1 Oskar C Aszmann2 1Institute of Neurorehabilitation Systems, Bernstein Focus Neurotechnology Göttingen, University Medical Center Göttingen, Georg-August University, Göttingen, Germany; 2Christian Doppler Laboratory for Restoration of Extremity Function, Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria Abstract: Absence of an upper limb leads to severe impairments in everyday life, which can further influence the social and mental state. For these reasons, early developments in cosmetic and body-driven prostheses date some centuries ago, and they have been evolving ever since. Following the end of the Second World War, rapid developments in technology resulted in powered myoelectric hand prosthetics. In the years to come, these devices were common on the market, though they still suffered high user abandonment rates. The reasons for rejection were trifold – insufficient functionality of the hardware, fragile design, and cumbersome control. In the last decade, both academia and industry have reached major improvements concerning technical features of upper limb prosthetics and methods for their interfacing and control. Advanced robotic hands are offered by several vendors and research groups, with a variety of active and passive wrist options that can be articulated across several degrees of freedom. Nowadays, elbow joint designs include active solutions with different weight and power options. Control features are getting progressively more sophisticated, offering options for multiple sensor integration and multi-joint articulation. Latest developments in socket designs are capable of facilitating implantable and multiple surface electromyography sensors in both traditional and osseointegration-based systems. Novel surgical techniques in combination with modern, sophisticated hardware are enabling restoration of dexterous upper limb

  13. Next-generation drug-eluting stents in coronary artery disease: focus on everolimus-eluting stent (Xience V®

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    Imad Sheiban

    2008-02-01

    Full Text Available Imad Sheiban1, Gianluca Villata1, Mario Bollati1, Dario Sillano1, Marzia Lotrionte2, Giuseppe Biondi-Zoccai11Interventional Cardiology, Division of Cardiology, University of Turin, Turin, Italy; 2Institute of Cardiology, Catholic University, Rome, ItalyAbstract: Percutaneous coronary revascularization has been a mainstay in the management of coronary artery disease since its introduction in the late 1970s. Bare-metal stents and, more recently, first-generation drug-eluting stents (DES, such as sirolimus-eluting (Cypher® and paclitaxel-eluting stents (Taxus®, have further improved results of percutaneous coronary intervention (PCI by improving early results and reducing the risk of restenosis. There is currently debate on the safety of these first-generation DES, given the potential for late stent thrombosis, especially after discontinuation of dual antiplatelet therapy. There are well known caveats on the performance of their respective metallic stent platforms, delivery, and dilation systems, and polymer coatings. Second-generation DES, such as zotarolimus-eluting (Endeavor® and everolimus-eluting stents (Xience V®, have recently become available in the USA and/or Europe. The Xience V stent holds the promise of superior anti-restenotic efficacy as well as long-term safety. In addition, this stent is based on the Multi-link platform and delivery system. Recently available data already suggest the superiority of the Xience V stent in comparison to the Taxus stent in terms of prevention of restenosis, without significant untoward events. Nonetheless, the number of patients studied and the follow-up duration are still too limited to enable definitive conclusions. Only indirect meta-analyses can be used to date to compare the Xience V with the Cypher. This systematic review tries to provide a concise and critical appraisal of the data in support of the Xience V everolimus-eluting stent.Keywords: coronary artery disease, everolimus, percutaneous

  14. Nanostructured ultra-thin patches for ultrasound-modulated delivery of anti-restenotic drug

    Directory of Open Access Journals (Sweden)

    Vannozzi L

    2015-12-01

    Full Text Available Lorenzo Vannozzi,1 Leonardo Ricotti,1 Carlo Filippeschi,2 Stefania Sartini,3 Vito Coviello,3 Vincenzo Piazza,4 Pasqualantonio Pingue,5 Concettina La Motta,3 Paolo Dario,1 Arianna Menciassi1 1The BioRobotics Institute, Scuola Superiore Sant’Anna, 2Center for MicroBioRobotics at SSSA, Istituto Italiano di Tecnologia, Pontedera, 3Department of Pharmacy, University of Pisa, 4Center for Nanotechnology Innovation at NEST, Istituto Italiano di Tecnologia, 5NEST, Scuola Normale Superiore, Istituto Nanoscienze-CNR, Pisa, Italy Abstract: This work aims to demonstrate the possibility to fabricate ultra-thin polymeric films loaded with an anti-restenotic drug and capable of tunable drug release kinetics for the local treatment of restenosis. Vascular nanopatches are composed of a poly(lactic acid supporting membrane (thickness: ~250 nm on which 20 polyelectrolyte bilayers (overall thickness: ~70 nm are alternatively deposited. The anti-restenotic drug is embedded in the middle of the polyelectrolyte structure, and released by diffusion mechanisms. Nanofilm fabrication procedure and detailed morphological characterization are reported here. Barium titanate nanoparticles (showing piezoelectric properties are included in the polymeric support and their role is investigated in terms of influence on nanofilm morphology, drug release kinetics, and cell response. Results show an efficient drug release from the polyelectrolyte structure in phosphate-buffered saline, and a clear antiproliferative effect on human smooth muscle cells, which are responsible for restenosis. In addition, preliminary evidences of ultrasound-mediated modulation of drug release kinetics are reported, thus evaluating the influence of barium titanate nanoparticles on the release mechanism. Such data were integrated with quantitative piezoelectric and thermal measurements. These results open new avenues for a fine control of local therapies based on smart responsive materials. Keywords

  15. Long-term outcomes in chronic obstructive pulmonary disease patients: exploring the effects of inhalatory devices and their influence on the outcome

    Directory of Open Access Journals (Sweden)

    Fadda V

    2016-04-01

    Full Text Available Valeria Fadda, Dario Maratea Department of Pharmaceutical Sciences, University of Florence, Sesto Fiorentino, FI, Italy Purpose: Numerous systematic reviews have examined the outcomes in patients with chronic obstructive pulmonary disease managed with different therapeutic strategies. However, no such studies have specifically focused on the effect of inhalation devices. Methods: A standard PubMed search was carried out in which we identified all randomized placebo-controlled trials conducted in patients with moderate-to-severe or severe chronic obstructive pulmonary disease. The clinical end points were exacerbations rate, incidence of pneumonia, and mortality. Meta-regression was employed to assess the effect of the device. For the incidence of exacerbations, an equivalence analysis was also carried out. Results: A total of 37 studies were analyzed. Four different devices were used across these trials (Respimat®, HandiHaler®, Diskus, and Turbuhaler®. Our meta-regression analysis failed to show any significant difference between devices with regard to exacerbation rate. Equivalence was shown for some comparisons (HandiHaler® vs Respimat®, but not for others. In analyzing mortality, Respimat® was shown to worsen this end point in comparison with Turbuhaler® and HandiHaler®. Moreover, Turbuhaler® showed a protective effect over Diskus in the incidence of pneumonia. Conclusion: The results of our analysis represent the first attempt to explore the effect of the type of device on long-term outcomes. One important limitation was that most drugs were associated with one particular device, and so the effects of drugs and devices could not be reliably differentiated from one another. Keywords: COPD, inhalation device, moderate-severe, meta-analysis, equivalence

  16. Strangers in Stranger Lands: Language, Learning, Culture

    Directory of Open Access Journals (Sweden)

    Hong Li

    2007-02-01

    Full Text Available This study investigates international students’ perceptions of the issues they face using English as a second language while attending American higher education institutions. In order to fully understand those challenges involved in learning English as a Second Language, it is necessary to know the extent to which international students have mastered the English language before they start their study in America. Most international students experience an overload of English language input upon arrival in the United States. Cultural differences influence international students’ learning of English in other ways, including international students’ isolation within their communities and America’s lack of teaching listening skills to its own students. Other factors also affect international students’ learning of English, such as the many forms of informal English spoken in the USA, as well as a variety of dialects. Moreover, since most international students have learned English in an environment that precluded much contact with spoken English, they often speak English with an accent that reveals their own language. This study offers informed insight into the complicated process of simultaneously learning the language and culture of another country. Readers will find three main voices in addition to the international students who “speak” (in quotation marks throughout this article. Hong Li, a Chinese doctoral student in English Education at the University of Missouri-Columbia, authored the “regular” text. Second, Roy F. Fox’s voice appears in italics. Fox is Professor of English Education and Chair of the Department of Learning, Teaching, and Curriculum at the University of Missouri-Columbia. Third, Dario J. Almarza’s voice appears in boldface. Almarza, a native of Venezuela, is an Assistant Professor of Social Studies Education at the same institution.

  17. Algunas novelas de Darío Fernández-Flórez: de Zarabanda (1944 a Alta Costura (1954. Temas escabrosos en tiempos de restricciones moralistas

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    Montejo Gurruchaga, Lucía

    2008-06-01

    Full Text Available Dario Fernández-Flórez begins in 1944 with Zarabanda a narrative style of intellectual eroticism and inmoral atmosphere which attracted no attention. Six years later he published Lola, espejo oscuro the recollections of a high prostitute. The novel was an scandal and an immediate success. Although the topic and its treatment were odd at the time because the strict moral values which mantained Franco´s regime were ignored, the novel was published with no cuts at all. Censorship was deaf to all the voices that warned of its dangers. This had an explanation: Darío Fernández-Flórez held an important post in the Propaganda National Service. After his dismissal censors were less lenient.Darío Fernández-Flórez inicia en 1944 con Zarabanda una narrativa de erotismo intelectualizado y ambiente amoral que no tuvo ningún eco. Seis años después publicará Lola, espejo oscuro, las memorias de una prostituta de alto copete. La novela suscitó un gran escándalo y su éxito fue inmediato. Aunque el tema y su tratamiento eran inusitados en aquellos momentos porque la obra daba al traste con los estrictos valores morales que sustentaban el régimen franquista, la novela fue publicada sin recortes; la censura hizo oídos sordos a todas las voces que alertaban de su peligro. Este hecho tiene una explicación: Darío Fernández-Flórez ocupaba un cargo importante en el Servicio Nacional de Propaganda. Tras su cese, los censores serán menos benevolentes.

  18. Effects of beclomethasone/formoterol fixed combination on lung hyperinflation and dyspnea in COPD patients

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    Tzani P

    2011-10-01

    Full Text Available Panagiota Tzani1, Ernesto Crisafulli2, Gabriele Nicolini3, Marina Aiello1, Alfredo Chetta1, Enrico Maria Clini2, Dario Olivieri1 1Department of Clinical Sciences, University of Parma, Parma, Italy; 2Department of Oncology Haematology and Pulmonary Diseases, University of Modena and Ospedale Villa Pineta, Pavullo, Modena, Italy; 3Medical Affairs Department, Chiesi Farmaceutici SpA, Parma, Italy Background: Chronic obstructive pulmonary disease (COPD is a common disease characterized by airflow obstruction and lung hyperinflation leading to dyspnea and exercise capacity limitation. Objectives: The present study was designed to evaluate whether an extra-fine combination of beclomethasone and formoterol (BDP/F was effective in reducing air trapping in COPD patients with hyperinflation. Fluticasone salmeterol (FP/S combination treatment was the active control. Methods: COPD patients with forced expiratory volume in one second <65% and plethysmographic functional residual capacity ≥120% of predicted were randomized to a double-blind, double-dummy, 12-week, parallel group, treatment with either BDP/F 400/24 µg/day or FP/S 500/100 µg/day. Lung volumes were measured with full body plethysmography, and dyspnea was measured with transition dyspnea index. Results: Eighteen patients were evaluable for intention to treat. A significant reduction in air trapping and clinically meaningful improvement in transition dyspnea index total score was detected in the BDP/F group but not in the FP/S group. Functional residual capacity, residual volume (RV and total lung capacity significantly improved from baseline in the BDP/F group only. With regard to group comparison, a significantly greater reduction in RV was observed with BDP/F versus FP/S. Conclusion: BDP/F extra-fine combination is effective in reducing air trapping and dyspnea in COPD patients with lung hyperinflation. Keywords: small airways, chronic obstructive pulmonary disease, airflow obstruction 

  19. Plastic matters: an analytical procedure to evaluate the degradability of contemporary works of art.

    Science.gov (United States)

    Lazzari, Massimo; Ledo-Suárez, Ana; López, Thaïs; Scalarone, Dominique; López-Quintela, M Arturo

    2011-03-01

    The most significant results concerning a chemical study to evaluate the degradability of polymeric components in four contemporary works of art, partially or completely realized in plastics, are presented and discussed in this paper. The procedure applied is mainly based on the use of Fourier transform IR and UV-vis spectroscopies and pyrolysis-gas chromatography/mass spectrometry, and consists of the following steps: (1) compositional analysis of the artworks, with particular attention to components which may have a negative effect on the overall ageing; (2) evaluation of the actual state of conservation; (3) investigation of the accelerated ageing of reference polymer samples; and (4) monitoring of the natural ageing of the artworks. On such a basis, the following could be concluded. Stage Evidence by Loris Cecchini is made of poly(ether urethane) elastomer which contains a high amount of phthalates. Their exudation gives a sticky appearance to the artwork and their removal during ageing is the main cause of the loss of flexibility. The latex used by Andrés Pinal for tailoring Traxe de Home is a natural polyisoprene, whose oxidative degradation accounts for the extensive deterioration and yellowing of the artwork. The plaster sculptures of 3D Bodyscans 1:9 by Karin Sander are coated with an aliphatic epoxy resin. Its oxidation with formation of amides is the cause of the surface yellowing. The adhesive used by Dario Villalba for Tierra, Ladrillo y Agua is a commercial poly(vinyl acetate). Simulated photoageing suggests a fast deterioration due to deacetylation and cross-linking, which possibly is the main reason for the actual detachment of debris from the support.

  20. Mithramycin encapsulated in polymeric micelles by microfluidic technology as novel therapeutic protocol for beta-thalassemia

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    Capretto L

    2012-01-01

    Full Text Available Lorenzo Capretto1, Stefania Mazzitelli2, Eleonora Brognara2, Ilaria Lampronti2, Dario Carugo1, Martyn Hill1, Xunli Zhang1, Roberto Gambari2, Claudio Nastruzzi31Engineering Sciences, University of Southampton, Southampton, UK; 2Department of Biochemistry and Molecular Biology, 3Department of Pharmaceutical Sciences, University of Ferrara, Ferrara, ItalyAbstract: This report shows that the DNA-binding drug, mithramycin, can be efficiently encapsulated in polymeric micelles (PM-MTH, based on Pluronic® block copolymers, by a new microfluidic approach. The effect of different production parameters has been investigated for their effect on PM-MTH characteristics. The compared analysis of PM-MTH produced by microfluidic and conventional bulk mixing procedures revealed that microfluidics provides a useful platform for the production of PM-MTH with improved controllability, reproducibility, smaller size, and polydispersity. Finally, an investigation of the effects of PM-MTH, produced by microfluidic and conventional bulk mixing procedures, on the erythroid differentiation of both human erythroleukemia and human erythroid precursor cells is reported. It is demonstrated that PM-MTH exhibited a slightly lower toxicity and more pronounced differentiative activity when compared to the free drug. In addition, PM-MTH were able to upregulate preferentially γ-globin messenger ribonucleic acid production and to increase fetal hemoglobin (HbF accumulation, the percentage of HbF-containing cells, and their HbF content without stimulating α-globin gene expression, which is responsible for the clinical symptoms of ß-thalassemia. These results represent an important first step toward a potential clinical application, since an increase in HbF could alleviate the symptoms underlying ß-thalassemia and sickle cell anemia. In conclusion, this report suggests that PM-MTH produced by microfluidic approach warrants further evaluation as a potential therapeutic protocol

  1. ‘Your Brain on Art’: Emergent cortical dynamics during aesthetic experiences

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    Kimberly eKontson

    2015-11-01

    Full Text Available The brain response to conceptual art was studied with mobile electroencephalography (EEG to examine the neural basis of aesthetic experiences. In contrast to most studies of perceptual phenomena, participants were moving and thinking freely as they viewed the exhibit The Boundary of Life is Quietly Crossed by Dario Robleto at the Menil Collection-Houston. The brain activity of over 400 subjects was recorded using dry-electrode and one reference gel-based EEG systems over a period of 3 months. Here, we report initial findings based on the reference system. EEG segments corresponding to each art piece were grouped into one of three classes (complex, moderate, and baseline based on analysis of a digital image of each piece. Time, frequency, and wavelet features extracted from EEG were used to classify patterns associated with viewing art, and ranked based on their relevance for classification. The maximum classification accuracy was 55% (chance = 33% with delta and gamma features the most relevant for classification. Functional analysis revealed a significant increase in connection strength in localized brain networks while subjects viewed the most aesthetically pleasing art compared to viewing a blank wall. The direction of signal flow showed early recruitment of broad posterior areas followed by focal anterior activation. Significant differences in the strength of connections were also observed across age and gender. This work provides evidence that EEG, deployed on freely behaving subjects, can detect selective signal flow in neural networks, identify significant differences between subject groups, and report with greater-than-chance accuracy the complexity of a subject’s visual percept of aesthetically pleasing art. Our approach, which allows acquisition of neural activity ‘in action and context’, could lead to understanding of how the brain integrates sensory input and its ongoing internal state to produce the phenomenon which we term

  2. Cancer patient-centered home care: a new model for health care in oncology

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    Tralongo P

    2011-09-01

    Full Text Available Paolo Tralongo1, Francesco Ferraù2, Nicolò Borsellino3, Francesco Verderame4, Michele Caruso5, Dario Giuffrida6, Alfredo Butera7, Vittorio Gebbia81Medical Oncology Unit, Azienda Sanitaria Provinciale, Siracusa; 2Medical Oncology Unit, Ospedale San Vincenzo, Taormina; 3Medical Oncology Unit, Ospedale Buccheri La Ferla, Palermo; 4Medical Oncology Unit, Ospedale Giovanni Paolo II, Sciacca; 5Medical Oncology Unit, Istituto Humanitas, Catania; 6Medical Oncology Unit, Istituto Oncologico del Mediterraneo, Catania; 7Medical Oncology Unit, Ospedale San Giovanni di Dio, Agrigento; 8Medical Oncology Unit, Dipartimento Oncologico, La Maddalena, Università degli Studi, Palermo, ItalyAbstract: Patient-centered home care is a new model of assistance, which may be integrated with more traditional hospital-centered care especially in selected groups of informed and trained patients. Patient-centered care is based on patients' needs rather than on prognosis, and takes into account the emotional and psychosocial aspects of the disease. This model may be applied to elderly patients, who present comorbid diseases, but it also fits with the needs of younger fit patients. A specialized multidisciplinary team coordinated by experienced medical oncologists and including pharmacists, psychologists, nurses, and social assistance providers should carry out home care. Other professional figures may be required depending on patients' needs. Every effort should be made to achieve optimal coordination between the health professionals and the reference hospital and to employ shared evidence-based guidelines, which in turn guarantee safety and efficacy. Comprehensive care has to be easily accessible and requires a high level of education and knowledge of the disease for both the patients and their caregivers. Patient-centered home care represents an important tool to improve quality of life and help cancer patients while also being cost effective.Keywords: cancer, home care

  3. Pustular psoriasis: pathophysiology and current treatment perspectives

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    Benjegerdes KE

    2016-09-01

    Full Text Available Katie E Benjegerdes,1 Kimberly Hyde,2 Dario Kivelevitch,3 Bobbak Mansouri1,4 1Texas A&M Health Science Center College of Medicine, Temple, 2Texas A&M Health Science Center College of Medicine, Round Rock, 3Division of Dermatology, Baylor University Medical Center, Dallas, 4Department of Dermatology, Scott and White Hospital, Texas A&M Health Science Center College of Medicine, Temple, TX, USA Abstract: Psoriasis vulgaris is a chronic inflammatory disease that classically affects skin and joints and is associated with numerous comorbidities. There are several clinical subtypes of psoriasis including the uncommon pustular variants, which are subdivided into generalized and localized forms. Generalized forms of pustular psoriasis include acute generalized pustular psoriasis, pustular psoriasis of pregnancy, and infantile and juvenile pustular psoriasis. Localized forms include acrodermatitis continua of Hallopeau and palmoplantar pustular psoriasis. These subtypes vary in their presentations, but all have similar histopathologic characteristics. The immunopathogenesis of each entity remains to be fully elucidated and some debate exists as to whether these inflammatory pustular dermatoses should be classified as entities distinct from psoriasis vulgaris. Due to the rarity of these conditions and the questionable link to the common, plaque-type psoriasis, numerous therapies have shown variable results and most entities remain difficult to treat. With increasing knowledge of the pathogenesis of these variants of pustular psoriasis, the development and use of biologic and other immunomodulatory therapies holds promise for the future of successfully treating pustular variants of psoriasis. Keywords: psoriasis, pustular psoriasis, generalized pustular psoriasis, von Zumbusch, impetigo herpetiformis, acrodermatitis continua of Hallopeau, palmoplantar pustulosis, biologic

  4. Cold plasma treatment in wound care: efficacy and risk assessment

    Science.gov (United States)

    Stoffels, Eva

    2007-10-01

    Cold atmospheric plasma is an ideal medium for non-destructive modification of vulnerable surfaces. One of the most promising medical applications of cold plasma treatment is wound healing. Potential advantages in wound healing have been demonstrated in vitro: the plasma does not necrotize the cells and does not affect the extracellular matrix [1], has clear bactericidal or bacteriostatic effects [2], and stimulates fibroblast cells towards faster attachment and proliferation [3]. However, safety issues, such as the potential cytotoxicity of the plasma must be clarified prior to clinical implementation. This work comprises the recent facts on sub-lethal plasma effects on mammalian cells, as well as studies on apoptosis induction and quantitative assessment of DNA damage. Fibroblast, smooth muscle and endothelial cells were treated using the standard cold plasma needle [1,2]; intra- and extracellular oxidant levels as well as the influence of the plasma on intracellular antioxidant balance were monitored using appropriate fluorescent markers [1]. We have studied long-term cellular damage was monitored using flow cytometry to determine the DNA profiles in treated cells. Dose-response curves were obtained: increased proliferation as well as apoptosis were visualized under different treatment conditions. The results from the in vitro studies are satisfying. [1] I.E. Kieft, ``Plasma needle: exploring biomedical applications of non-thermal plasmas'', PhD Thesis, Eindhoven University of Technology (2005). [2] R.E.J. Sladek, ``Plasma needle: non-thermal atmospheric plasmas in dentistry'' PhD Thesis, Eindhoven University of Technology (2006). [3] I.E. Kieft, D. Darios, A.J.M. Roks, E. Stoffels, IEEE Trans. Plasma Sci. 34(4), 2006, pp. 1331-1336.

  5. 丝带住宅%Ribbon House

    Institute of Scientific and Technical Information of China (English)

    朱利峰

    2011-01-01

    G2 Estudio是两个喜欢探险的合伙人Dario Gallego和Hugo Gallego在2002年创立的建筑设计事务所,他们专注于实验性的提案以及对建筑设计新理念的探索.2008年开始,G2 Estudlo受法属波利尼西亚塔西提岛上两个家庭的委托,在阿根廷南部小镇SanCarlos de Bariloche建造一幢富有探索精神的度假小屋.这里素有“南美小瑞士”的美称,当地的卡特德拉尔滑雪中心是世界十大滑雪胜地之一.每年6月至9月,正当欧亚美处于盛夏之际,这里却大雪纷飞、银装素裹,世界各地的滑雪爱好者都蜂拥而至;每年8月,这里会举行盛大的冰雪节,期间有滑雪比赛、冰球比赛、火炬游行等活动,是赴南美旅行必到的度假胜地.度假屋的委托人没有给项目设定过多的限制,只是提出在功能上要有一个供集中休闲娱乐的宽敞的合成空间,两间主卧室,两间儿童房,以及作为度假屋应具备的所有必要设施.

  6. Your Brain on Art: Emergent Cortical Dynamics During Aesthetic Experiences.

    Science.gov (United States)

    Kontson, Kimberly L; Megjhani, Murad; Brantley, Justin A; Cruz-Garza, Jesus G; Nakagome, Sho; Robleto, Dario; White, Michelle; Civillico, Eugene; Contreras-Vidal, Jose L

    2015-01-01

    The brain response to conceptual art was studied with mobile electroencephalography (EEG) to examine the neural basis of aesthetic experiences. In contrast to most studies of perceptual phenomena, participants were moving and thinking freely as they viewed the exhibit The Boundary of Life is Quietly Crossed by Dario Robleto at the Menil Collection-Houston. The brain activity of over 400 subjects was recorded using dry-electrode and one reference gel-based EEG systems over a period of 3 months. Here, we report initial findings based on the reference system. EEG segments corresponding to each art piece were grouped into one of three classes (complex, moderate, and baseline) based on analysis of a digital image of each piece. Time, frequency, and wavelet features extracted from EEG were used to classify patterns associated with viewing art, and ranked based on their relevance for classification. The maximum classification accuracy was 55% (chance = 33%) with delta and gamma features the most relevant for classification. Functional analysis revealed a significant increase in connection strength in localized brain networks while subjects viewed the most aesthetically pleasing art compared to viewing a blank wall. The direction of signal flow showed early recruitment of broad posterior areas followed by focal anterior activation. Significant differences in the strength of connections were also observed across age and gender. This work provides evidence that EEG, deployed on freely behaving subjects, can detect selective signal flow in neural networks, identify significant differences between subject groups, and report with greater-than-chance accuracy the complexity of a subject's visual percept of aesthetically pleasing art. Our approach, which allows acquisition of neural activity "in action and context," could lead to understanding of how the brain integrates sensory input and its ongoing internal state to produce the phenomenon which we term aesthetic experience.

  7. The Literary Criticism and Memoirs of Juan Ramón Jiménez

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    Allen W. Phillips

    1983-01-01

    Full Text Available Equally as demanding of others as he was of himself, Juan Ramón Jiménez conceived of literary criticism as a serious and exacting task. The critic and the poet, standing side by side, are devoted to complementary activities of mutual enrichment. However fragmentary and partial the critical opinions of Juan Ramón may be (also outspoken and polemical in nature, they are invaluable as a personal historical and aesthetic guide to about fifty or sixty years of Hispanic literary development (1900-1960. Not to take them into account is to fail to recognize a highly important aspect of his total artistic personality. These varied critical texts are a product of a first rate intelligence and the sensibility of a writer of consummate discrimination who was endowed not only with an excellent memory but also a very special talent for appreciating the authentic. Juan Ramón as a critic is quick to praise (San Juan, Bécquer, Dario, Unamuno and Machado and at the same time strong in his censure of certain contemporaries. Several recently collected volumes of miscellaneous critical materials have resolved the bibliographical muddle for the initial study of this fundamental aspect of the poet, but still particularly important are the expressionistic portraits of Españoles de tres mundos , longer tributes to Valle, Ortega and Villaespesa as well as the extensive lectures delivered in his latter years. Examination of these pages gives us an historical and creative overview of the period in which he lived and worked in addition to original considerations about the evolution of Hispanic poetry. Of course, one of the constant focal points of his literary criticism was the modernist epoch of his early days, a movement or attitude which he considered to be a modern twentieth century renaissance. Together with detailed study of these two areas of historical and aesthetic nature, in the ensuing pages some conclusions are pointed out as to the essence of poetry

  8. Self-reported adherence supports patient preference for the single tablet regimen (STR in the current cART era

    Directory of Open Access Journals (Sweden)

    Sterrantino G

    2012-06-01

    Full Text Available Gaetana Sterrantino,1 Lucia Santoro,1 Dario Bartolozzi1,1 Michele Trotta,1 Mauro Zaccarelli21SOD Malattie Infettive, Azienda Ospedaliera Universitaria Careggi, Firenze, 2Istituto Nazionale per le Malattie Infettive "Lazzaro Spallanzani," Roma, ItalyObjective: To analyze self-reported adherence to antiretroviral regimens containing ritonavir-boosted protease inhibitors, nonnucleoside reverse transcriptase inhibitors (NNRTI, raltegravir, and maraviroc.Methods: Overall, 372 consecutive subjects attending a reference center for HIV treatment in Florence, Italy, were enrolled in the study, from December 2010 to January 2012 (mean age 48 years. A self-report questionnaire was filled in. Patients were defined as "nonadherent" if reporting one of the following criteria: <90% of pills taken in the last month, ≥1 missed dose in the last week, spontaneous treatment interruptions reported, or refill problems in the last 3 months. Gender, age, CD4, HIV-RNA, years of therapy, and type of antiretroviral regimen were analyzed with respect to adherence.Results: At the time of the questionnaire, 89.8% of patients had <50 copies/mL HIV-RNA and 14.2% were on their first combined antiretroviral therapy. 57% of patients were prescribed a regimen containing ritonavir boosted protease inhibitors (boosted PI, 41.7% NNRTI, 17.2% raltegravir, and 4.8% maraviroc; 49.5% of the subjects were on bis-in-die regimens, while 50.5% were on OD regimens, with 23.1% of these on the single tablet regimen (STR: tenofovir/emtricitabine/efavirenz. The nonadherence proportion was lower in NNRTI than in boosted-PI treatments (19.4% vs 30.2%, and even lower in STR patients (17.4%. In multivariable logistic regression, patients with the NNRTI regimen (OR: 0.56, 95% CI: 0.34–0.94 and the STR (OR: 0.45, 95% CI: 0.22–0.92 reported lower nonadherence. Efavirenz regimens were also associated with lower nonadherence (OR: 0.42, 95% CI: 0.21–0.83, while atazanavir/ritonavir regimens were

  9. Pressure injuries in elderly with acute myocardial infarction

    Directory of Open Access Journals (Sweden)

    Komici K

    2017-09-01

    Full Text Available Klara Komici,1 Dino F Vitale,2 Dario Leosco,1 Angela Mancini,1 Graziamaria Corbi,3 Leonardo Bencivenga,1 Alessandro Mezzani,4 Bruno Trimarco,5 Carmine Morisco,5 Nicola Ferrara,1,2 Giuseppe Rengo1,2 1Division of Geriatrics, Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy; 2Cardiac Rehabilitation Division, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Telese Terme (BN, Telese Terme, Italy; 3Department of Medicine and Health Sciences, University of Molise Campobasso, Campobasso, Italy; 4Cardiac Rehabilitation Division, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Veruno, Veruno, Italy; 5Division of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy Objectives: To assess pressure injury (PI incidence among patients hospitalized for acute myocardial infarction (AMI in an intensive coronary care unit (ICCU and to detect the impact of specific risk factors on the development of PI in this clinical setting.Patients and methods: Prospective cohort study in ICCU setting. Patients admitted for AMI: patients mean age 67.5±11.5 years (n=165. Norton Scale, Mini Nutritional Assessment (MNA, demographic, clinical and biochemical data collected at the time of ICCU admission have been tested in a logistic model to assess the odds ratios (ORs of PI risk development. The jackknifed area under the receiver operating characteristic curve (AUC and the decision curve analysis have been employed to assess the additive predictive value of a factor.Results: Twenty-seven (16.3% patients developed PIs. An increased PI risk was associated with advanced age (OR =2.5 every 10-year increase; 95% CI =1.1–5.7, while probability of PI development was reduced in patients with higher left ventricular ejection fraction (LVEF (OR =0.4 every 5% increase; 95% CI =0.24–0.66, MNA score (OR =0.65 every unit change; 95% CI =0.44–0.95 and Norton Scale score

  10. The tactical development of Achaemenid cavalry

    Directory of Open Access Journals (Sweden)

    Nefedkin, Alexander K.

    2006-12-01

    Full Text Available

    In the 6th and first half of the 5th century BC, Persian horsemen were armed with bows and javelins, and fought as a light cavalry. In the second half of the 5th century in the western regions of the Persian empire there was an increase in heavily-armoured cavalry, armed with the spears (palta for thrusting and throwing. I propose that this evolution is connected with the long wars against the Greeks and the deterioration of the morale quality of Persian warriors. The attempt of the last Persian king Darius III to re-arm his horsemen with lances to fight the Macedonian Companions did not succeed in saving the Achaemenid empire from collapse.



    En el siglo VI y la primera mitad del siglo V A. C. los caballeros persianos fueron armados con arcos y jabalinas y luchaban como caballeria ligera. En la segunda mitad del siglo V A.C. en las regiones occidentales del Imperio Persa se extienden caballeros de armadura pesada, armados con lanzas (palta, aunque la mayor parte de caballeria estaba formada con armados ligeramente. Segun mi opinion, estos cambios en caballeria persiana eston relacionados con la lenta guerra contra los griegos y tambien con empeoramiento de completacion de caballeria local. El intento de Dario III de rearmar a sus caballeros con las lanzas largas para luchar con exito con caballeria macedonica, fracaso por causa de caida del Imperio Aquemenido.

  11. Effects of balance training using a virtual-reality system in older fallers

    Directory of Open Access Journals (Sweden)

    Duque G

    2013-02-01

    Full Text Available Gustavo Duque,1,2 Derek Boersma,1 Griselda Loza-Diaz,2 Sanobar Hassan,1 Hamlet Suarez,3 Dario Geisinger,3 Pushpa Suriyaarachchi,1 Anita Sharma,1 Oddom Demontiero1,21Falls and Fractures Clinic, Department of Geriatric Medicine, Nepean Hospital, Penrith, NSW, Australia; 2Ageing Bone Research Program, Division of Geriatric Medicine, Sydney Medical School Nepean, The University of Sydney, Penrith, NSW, Australia; 3British Hospital, CLAEH School of Medicine, Montevideo, UruguayAbstract: Poor balance is considered a challenging risk factor for falls in older adults. Therefore, innovative interventions for balance improvement in this population are greatly needed. The aim of this study was to evaluate the effect of a new virtual-reality system (the Balance Rehabilitation Unit [BRU] on balance, falls, and fear of falling in a population of community-dwelling older subjects with a known history of falls. In this study, 60 community-dwelling older subjects were recruited after being diagnosed with poor balance at the Falls and Fractures Clinic, Nepean Hospital (Penrith, NSW, Australia. Subjects were randomly assigned to either the BRU-training or control groups. Both groups received the usual falls prevention care. The BRU-training group attended balance training (two sessions/week for 6 weeks using an established protocol. Change in balance parameters was assessed in the BRU-training group at the end of their 6-week training program. Both groups were assessed 9 months after their initial assessment (month 0. Adherence to the BRU-training program was 97%. Balance parameters were significantly improved in the BRU-training group (P < 0.01. This effect was also associated with a significant reduction in falls and lower levels of fear of falling (P < 0.01. Some components of balance that were improved by BRU training showed a decline after 9 months post-training. In conclusion, BRU training is an effective and well-accepted intervention to improve balance

  12. Construcción de un test de matemática para adolescentes y adultos

    Directory of Open Access Journals (Sweden)

    Nuria Cortada de Kohan

    2007-01-01

    Full Text Available El propósito de este trabajo es presentar un test de matemática construido con una muestra de 564 sujetos, para evaluar los conocimientos matemáticos de jóvenes con estudios se cun - darios completos o que están cursando el primer año de ca rre - ras universitarias. La muestra tiene una edad promedio de 24 años (DE = 8.7 años y está constituida por un 40% de varones y un 60% de mujeres. El instrumento consta de 50 ítem que eva lúan cálculos aritméticos simples, cálculos con decimales, pro porciones, regla de tres simple, algunos problemas algebraicos de pasaje de términos y algunos problemas de tipo geométrico. Todos los ítem son de opción múltiple con cuatro al ter - nativas, de las cuales sólo una es la correcta. La media de los puntajes totales es 25.36 (DE = 8.06. Se realizó un análisis de ítem calculando el porcentaje de respuestas correctas para cada uno de ellos, se analizaron los errores y se calculó para cada ítem su co rrelación con el puntaje total. El resultado del alpha de Cronbach para la confiabilidad total es .936. Para obtener la validez de constructo del test se ha realizado un análisis factorial, en el que sobresale un factor muy claro que satura a una gran cantidad de ítem, en su mayoría de tipo cálculo aritmético, y otros tres factores cuya interpretación es más difícil, que saturan a los ítem en forma mínima. El test mide fundamental

  13. VizieR Online Data Catalog: The Initial Gaia Source List (IGSL) (Smart, 2013)

    Science.gov (United States)

    Smart, R. L.; Nicastro, L.

    2013-11-01

    The IGSL is a compilation catalog produced for the Gaia mission. We have combined data from the following catalogs or datasets to produce a homogenous list of positons, proper motions, photometry in a blue and red band and estimates of the magnitudes in the Gaia G and G_RVS bands. Included Catalogs: Tycho2, LQRF, UCAC4, SDSS-DR9, PPMXL, GSC23, GEPC, OGLE, Sky2000, 2MASS. Note that in compiling the various entries we did not consider the individual flags. Overall, we think this catalog is reliable but there will be errors, mismatches and duplicates. The user should use this catalog with that in mind, it is fine for statistical studies that has some way to remove obviously incorrect entries but it should only be used with care for individual objects. The source catalogs used to produce the IGSL are: * The Gaia Ecliptic Pole Catalog, version 3.0 (GEPC) Altmann & Bastian 2009, "Ecliptic Poles Catalogue Version 1.1" ESA Document GAIA-C3-TN-ARI-MA-002 URL http://www.rssd.esa.int/llink/livelink/open/2885828 * GSC2.3: GSC2 version 2.3, Lasker et al. 2008AJ....136..735L (I/305) * an excerpt of the 4th version of the Gaia Initial QSO Catalog (GIQC) as compiled by the GWP-S-335-13000, formed by Alexandre H. Andrei, Christophe Barache, Dario N. da Silva Neto, Francois Taris, Geraldine Bourda, Jean-Francois Le Campion, Jean Souchay, J.J. Pereira Osorio, Julio I. Bueno de Camargo, Marcelo Assafin, Roberto Vieira Martins, Sebastien Bouquillon, Sebastien Lambert, Sonia Anton, Patrick Charlot * OGLE: Optical Gravitational Lensing Experiment version III (Szymaski et al., 2011, Cat. J/AcA/61/83) * PPMXL: Positions and Proper Motions "Extra Large" Catalog, Roeser et al. (2010, Cat. I/317) * SDSS: Sloan Digital Sky Survey data release 9, Cat. V/139 * UCAC4: Zacharias et al., 2012, Cat. I/322 * Tycho-2, Hoeg et al., 2000, Cat. I/259 (1 data file).

  14. Combined isosorbide dinitrate and ibuprofen as a novel therapy for muscular dystrophies: evidence from Phase I studies in healthy volunteers

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    Cossu MV

    2014-05-01

    Full Text Available Maria Vittoria Cossu,1 Dario Cattaneo,1 Serena Fucile,1 Paolo Pellegrino,1 Sara Baldelli,1 Valeria Cozzi,1 Amedeo Capetti,2 Emilio Clementi1,3 1Unit of Clinical Pharmacology, Consiglio Nazionale delle Ricerche Institute of Neuroscience, Department of Biomedical and Clinical Sciences, University Hospital “Luigi Sacco”, Università di Milano, Milan, Italy; 2Unit of Infectious Diseases, University Hospital “Luigi Sacco”, Milan, Italy; 3Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Lecco, Italy Abstract: We designed two Phase I studies that assessed healthy volunteers in order to evaluate the safety and to optimize the dosing of the combination of the drugs isosorbide dinitrate, a nitric oxide donor, and ibuprofen, a nonsteroidal antiinflammatory drug. We designed these studies with the aim of designing a Phase II trial to evaluate the drugs’ efficacy in patients affected by Duchenne muscular dystrophy. For the first trial, ISOFEN1, a single-dose, randomized-sequence, open-label, active control, three-treatment cross-over study, was aimed at comparing the pharmacokinetics of ibuprofen 200 mg and isosorbide dinitrate 20 mg when given alone and concomitantly. The pharmacokinetics of ibuprofen given alone versus ibuprofen given concomitantly with isosorbide dinitrate were similar, as documented by the lack of statistically significant differences in the main drug’s pharmacokinetic parameters (time to maximal concentration [Tmax], maximal concentration [Cmax], area under the curve [AUC]0–t, and AUC0–∞. Similarly, we found that the coadministration of ibuprofen did not significantly affect the pharmacokinetics of isosorbide dinitrate. No issues of safety were detected. The second trial, ISOFEN2, was a single-site, dose titration study that was designed to select the maximum tolerated dose for isosorbide dinitrate when coadministered with ibuprofen. Eighteen out of the 19 enrolled subjects tolerated the treatment well, and

  15. Impact of therapeutic drug monitoring of antiretroviral drugs in routine clinical management of patients infected with human immunodeficiency virus and related health care costs: a real-life study in a large cohort of patients

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    Perrone V

    2014-07-01

    Full Text Available Valentina Perrone,1 Dario Cattaneo,1 Sonia Radice,1 Diego Sangiorgi,2 Augusto B Federici,3 Maria Rita Gismondo,4 Massimo Medaglia,5 Valeria Micheli,4 Stefania Vimercati,5 Enza Pallone,6 Luca Degli Esposti,2 Emilio Clementi1,71Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, L Sacco University Hospital, University of Milan, Milan, 2CliCon Srl, Health, Economics and Outcomes Research, Ravenna, 3Hematology and Transfusion Medicine, Department of Clinical Sciences and Community Health, 4Clinical Microbiology Virology and Diagnosis of Bioemergency, 5Pharmaceutical Department, 6Quality Clinical Risk and Accreditation Unit, L Sacco University Hospital, Milan, 7Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Lecco, ItalyBackground: Highly active antiretroviral therapy (HAART has reduced morbidity and mortality in patients infected with human immunodeficiency virus (HIV. Studies have documented high interindividual variability in the pharmacokinetics of antiretroviral drugs, which may impair the success of HAART if not managed properly. Therapeutic drug monitoring (TDM is a useful diagnostic tool that helps clinicians to optimize drug doses so that drug concentrations associated with the highest therapeutic efficacy are obtained with a reduced risk of concentration-dependent adverse effects. The aim of this study was to assess whether use of TDM improves clinical outcomes and cost of illness.Methods: A retrospective cohort study was conducted at L Sacco University Hospital in Milan, Italy, in HIV-infected patients aged ≥18 years with at least one prescription of antiretroviral drugs for which TDM was applied. The inclusion period was from January 2010 to December 2011, with a follow-up period of up to 12 months. Laboratory and administrative databases were analyzed and matched with each other.Results: The cohort consisted of 5,347 patients (3,861 males and 1,486 females of mean age 43.9±12.5 years. We found

  16. Diabetes reversal via gene transfer: building on successes in animal models

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    Gerace D

    2015-01-01

    Full Text Available Dario Gerace,1,* Rosetta Martiniello-Wilks,1,2,* Ann M Simpson1 1School of Medical and Molecular Biosciences, Centre for Health Technologies, 2Translational Cancer Research Group, University of Technology Sydney, Sydney, NSW, Australia  *These authors contributed equally to this work Abstract: Type 1 diabetes (T1D is caused by the autoimmune destruction of the insulin-producing pancreatic β-cells. People with T1D manage their hyperglycemia using daily insulin injections; however, this does not prevent the development of long-term diabetic complications such as retinopathy, nephropathy, neuropathy, and various macrovascular disorders. Currently, the only "cure" for T1D is pancreas transplantation or islet-cell transplantation; however, this is hampered by the limited number of donors and the requirement for life-long immunosuppression. As a result, the need for alternative therapies is vital. One of the strategies employed to correct T1D is the use of gene transfer to generate the production of an “artificial” β-cell that is capable of secreting insulin in response to fluctuating glucose concentrations that normally occurs in people without T1D. The treatment of many diseases using cell and gene therapy is generating significant attention in the T1D research community; however, for a cell therapy to enter clinical trials, success and safety must first be shown in an appropriate animal model. Animal models have been used in diabetes research for over a century, have improved our understanding of the pathophysiology of diabetes, and have led to the discovery of useful drugs for the treatment of the disease. Currently, the nonobese diabetic mouse is the animal model of choice for the study of T1D as it most closely reflects disease development in humans. The aim of this review is to evaluate the success of cell and gene therapy to reverse T1D in animal models for future clinical application. Keywords: β-cell transcription factors, animal

  17. Dipeptidyl peptidase-4 inhibitors in type 2 diabetes therapy – focus on alogliptin

    Directory of Open Access Journals (Sweden)

    Capuano A

    2013-09-01

    Full Text Available Annalisa Capuano,1 Liberata Sportiello,1 Maria Ida Maiorino,2 Francesco Rossi,1 Dario Giugliano,2 Katherine Esposito3 1Department of Experimental Medicine, 2Department of Medical, Surgical, Neurological, Metabolic Sciences, and Geriatrics, 3Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, Naples, Italy Abstract: Type 2 diabetes mellitus is a complex and progressive disease that is showing an apparently unstoppable increase worldwide. Although there is general agreement on the first-line use of metformin in most patients with type 2 diabetes, the ideal drug sequence after metformin failure is an area of increasing uncertainty. New treatment strategies target pancreatic islet dysfunction, in particular gut-derived incretin hormones. Inhibition of the enzyme dipeptidyl peptidase-4 (DPP-4 slows degradation of endogenous glucagon-like peptide-1 (GLP-1 and thereby enhances and prolongs the action of the endogenous incretin hormones. The five available DPP-4 inhibitors, also known as 'gliptins' (sitagliptin, vildagliptin, saxagliptin, linagliptin, alogliptin, are small molecules used orally with similar overall clinical efficacy and safety profiles in patients with type 2 diabetes. The main differences between the five gliptins on the market include: potency, target selectivity, oral bioavailability, long or short half-life, high or low binding to plasma proteins, metabolism, presence of active or inactive metabolites, excretion routes, dosage adjustment for renal and liver insufficiency, and potential drug–drug interactions. On average, treatment with gliptins is expected to produce a mean glycated hemoglobin (HbA1c decrease of 0.5%–0.8%, with about 40% of diabetic subjects at target for the HbA1c goal <7%. There are very few studies comparing DPP-4 inhibitors. Alogliptin as monotherapy or added to metformin, pioglitazone, glibenclamide, voglibose, or insulin therapy significantly improves glycemic control

  18. A 500-year overview and analysis of flood changes in Europe: preliminary results

    Science.gov (United States)

    Kiss, Andrea

    2014-05-01

    Long-term flood series can be gained by combining evidence and systematic hydrological observations. Following various already existing local and regional studies, an important aim of the present work is to create a broad European database of long flood chronologies and to use them for detecting changes in flood regimes with respect to common break points. Another aim of the investigations is to reveal the main causes (e.g. atmospheric, human) of these changes and study spatial and temporal variability of floods on a European scale. In the presentation we provide an overview on the current stage of these Europe-wide investigations, including the available source types (i.e. documentary and instrumental), geographical coverage, temporal and spatial distribution of long-term flood series applied in the study. The first research results concerns basic information on magnitude, frequency and seasonality of floods (with special consideration of detectable changes). Full list of authors in alphabetic order: Mariano Barriendos (1), Günter Blöschl (2), Rudolf Brázdil (3), Gerardo Benito (4), Chiara Bertolin (5), Dario Camuffo (5), Gaston Demarée (6), Líbor Elleder (7), Silvi Enzi (8), Rüdiger Glaser (9), Julia Hall (2), Andrea Kiss (2), Oldrich Kotyza (10), Carmen Maria del Llasat (1), Neil MacDonald (11), Rui Perdigao (2), Dag Retsö (12), Lars Roald (13), Josep Luis Ruiz Bellet (1), Johannes Schönbeim (9), Petra Schmocker-Fackel (14), Lothar Schulte (1), Hubert Valasek (15), Oliver Wetter (16) (1) Faculty of Geography and History, University of Barcelona, Spain (2) Institute of Hydrological Engineering and Water Resources Management, TU Wien (3) Institute of Geography, Masaryk University Brno, Czech Republic (4) Laboratory of Hydrology and Geomorphology, Center of Env. Sciences, Madrid, Spain (5) Institute of Atmospheric Sciences and Climate, National Research Council, Rome, Italy (6) Royal Meteorological Institute, Brussels, Belgium (7) Research Group of

  19. IBC's 23rd Antibody Engineering and 10th Antibody Therapeutics Conferences and the Annual Meeting of The Antibody Society: December 2-6, 2012, San Diego, CA.

    Science.gov (United States)

    Marquardt, John; Begent, Richard H J; Chester, Kerry; Huston, James S; Bradbury, Andrew; Scott, Jamie K; Thorpe, Philip E; Veldman, Trudi; Reichert, Janice M; Weiner, Louis M

    2012-01-01

    Now in its 23rd and 10th years, respectively, the Antibody Engineering and Antibody Therapeutics conferences are the Annual Meeting of The Antibody Society. The scientific program covers the full spectrum of challenges in antibody research and development from basic science through clinical development. In this preview of the conferences, the chairs provide their thoughts on sessions that will allow participants to track emerging trends in (1) the development of next-generation immunomodulatory antibodies; (2) the complexity of the environment in which antibodies must function; (3) antibody-targeted central nervous system (CNS) therapies that cross the blood brain barrier; (4) the extension of antibody half-life for improved efficacy and pharmacokinetics (PK)/pharmacodynamics (PD); and (5) the application of next generation DNA sequencing to accelerate antibody research. A pre-conference workshop on Sunday, December 2, 2012 will update participants on recent intellectual property (IP) law changes that affect antibody research, including biosimilar legislation, the America Invents Act and recent court cases. Keynote presentations will be given by Andreas Plückthun (University of Zürich), who will speak on engineering receptor ligands with powerful cellular responses; Gregory Friberg (Amgen Inc.), who will provide clinical updates of bispecific antibodies; James D. Marks (University of California, San Francisco), who will discuss a systems approach to generating tumor targeting antibodies; Dario Neri (Swiss Federal Institute of Technology Zürich), who will speak about delivering immune modulators at the sites of disease; William M. Pardridge (University of California, Los Angeles), who will discuss delivery across the blood-brain barrier; and Peter Senter (Seattle Genetics, Inc.), who will present his vision for the future of antibody-drug conjugates. For more information on these meetings or to register to attend, please visit www

  20. PREFACE: 11th International Conference on Nucleus-Nucleus Collisions (NN2012)

    Science.gov (United States)

    Li, Bao-An; Natowitz, Joseph B.

    2013-03-01

    Nuclear Science and Technologies 6. Nuclear Reactions and Structure of Unstable Nuclei 7. Equation of State of Neutron-Rich Nuclear Matter, Clusters in Nuclei and Nuclear Reactions 8. Fusion and Fission 9. Nuclear Astrophysics 10. New Facilities and Detectors We would like to thank Texas A&M University and Texas A&M University-Commerce for their organizational support and for providing financial support for many students and postdocs and those who had special need. This support helped assure the success of NN2012. Special thanks also go to all members of the International Advisory Committee and the Local Organizing Committee (listed below) for their great work in advising upon, preparing and executing the NN2012 scientific program as well as the social events that all together made the NN2012 an enjoyable experience for both the participants and their companions. NN2012 International Advisory Committee N Auerbach (Israel) J Aysto (Finland) C Beck (France) S Cherubini (Italy) L Ferreira (Portugal) C Gagliardi (USA) S Gales (France) C Gale (Canada) W Gelletly (Great Britain) Paulo R S Gomes (Brazil) W Greiner (Germany) W Henning (USA) D Hinde (Australia) S Hofmann (Germany) M Hussein (Brazil) B Jacak (USA) S Kailas (India) W G Lynch (USA) Z Majka (Poland) L McLerran (USA) V Metag (Germany) K Morita (Japan) B Mueller (USA) D G Mueller (France) T Motobayashi (Japan) W Nazarewicz (USA) Y Oganessian (Russia) J Nolen (USA) E K Rehm (USA) N Rowley (France) B Sherrill (USA) J Schukraft (Switzerland) W Q Shen (China) A Stefanini (Italy) H Stoecker (Germany) A Szanto de Toledo (Brazil) U van Kolck (USA) W von Oertzen (Germany) M Wiescher (USA) N Xu (USA) N V Zamfir (Romania) W L Zhan (China) H Q Zhang (China) NN2012 Local Organizing Committee Marina Barbui Carlos Bertulani Robert Burch Jr Cheri Davis Cody Folden Kris Hagel John Hardy Bao-An Li (Co-Chair and Scientific Secretary) Joseph Natowitz (Co-Chair) Ralf Rapp Livius Trache Sherry Yennello Editors of NN2012 Proceedings Bao

  1. FOREWORD: Foreword

    Science.gov (United States)

    Covello, Aldo; Gargano, Angela

    2011-01-01

    RanaN Lo Iudice A. Porrino INTERNATIONAL ADVISORY COMMITTEE J Äystö (Jyväskylä)D Morrissey (Michigan) A B Balantekin (Wisconsin)W Nazarewicz (Oak Ridge) B R Barrett (Tucson)P von Neumann-Cosel (Darmstadt) P G Bizzeti (Firenze)R Okamoto (Kyushu) Y Blumenfeld (CERN and IPN Orsay)A V Ramayya (Vanderbilt) J Dobaczewski (Warsaw)J Schiffer (Argonne) G Fiorentini (Ferrara)A C Shotter (Edinburgh) B Fornal (Kraków)Ch Stoyanov (Sofia) S Gales (GANIL)I Talmi (Rehovot) F Iachello (Yale)P van Duppen (Leuven) R Jolos (Dubna)A Vitturi (Padova) M Lattuada (Catania) SPONSORS OF THE SEMINAR Dipartimento di Scienze Fisiche, Università di Napoli "Federico II" Istituto Nazionale di Fisica NucleareUniversità di Napoli Federico II

  2. Axially deformed solution of the Skyrme-Hartree-Fock-Bogoliubov equations using the transformed harmonic oscillator basis (II) HFBTHO v2.00d: A new version of the program

    Science.gov (United States)

    Stoitsov, M. V.; Schunck, N.; Kortelainen, M.; Michel, N.; Nam, H.; Olsen, E.; Sarich, J.; Wild, S.

    2013-06-01

    of the transformed harmonic oscillator, which allows for an accurate description of deformation effects and pairing correlations in nuclei arbitrarily close to the particle drip lines. Solution method: The program uses the axial Transformed Harmonic Oscillator (THO) single- particle basis to expand quasi-particle wave functions. It iteratively diagonalizes the Hartree-Fock-Bogoliubov Hamiltonian based on generalized Skyrme-like energy densities and zero-range pairing interactions until a self-consistent solution is found. A previous version of the program was presented in: M.V. Stoitsov, J. Dobaczewski, W. Nazarewicz, P. Ring, Comput. Phys. Commun. 167 (2005) 43-63. Reasons for new version: Version 2.00d of HFBTHO provides a number of new options such as the optional breaking of reflection symmetry, the calculation of axial multipole moments, the finite temperature formalism for the HFB method, optimized multi-constraint calculations, the treatment of odd-even and odd-odd nuclei in the blocking approximation, and the framework for generalized energy density with arbitrary density-dependences. It is also the first version of HFBTHO to contain threading capabilities. Summary of revisions: The modified Broyden method has been implemented, Optional breaking of reflection symmetry has been implemented, The calculation of all axial multipole moments up to λ=8 has been implemented, The finite temperature formalism for the HFB method has been implemented, The linear constraint method based on the approximation of the Random Phase Approximation (RPA) matrix for multi-constraint calculations has been implemented, The blocking of quasi-particles in the Equal Filling Approximation (EFA) has been implemented, The framework for generalized energy density functionals with arbitrary density-dependence has been implemented, Shared memory parallelism via OpenMP pragmas has been implemented. Restrictions: Axial- and time-reversal symmetries are assumed. Unusual features: The user must

  3. PREFACE: IUPAP C20 Conference on Computational Physics (CCP 2011)

    Science.gov (United States)

    Troparevsky, Claudia; Stocks, George Malcolm

    2012-12-01

    . We are grateful to the committees that helped put the conference together, especially the local organizing committee. Particular thanks are also due to a number of ORNL staff who spent long hours with the administrative details. We are pleased to express our thanks to the conference administrator Ann Strange (ORNL/CDP) for her responsive and efficient day-to-day handling of this event, Sherry Samples, Assistant Conference Administrator (ORNL), Angie Beach and the ORNL Conference Office, and Shirley Shugart (ORNL) and Fern Stooksbury (ORNL) who created and maintained the conference website. Editors: G Malcolm Stocks (ORNL) and M Claudia Troparevsky (UT) http://ccp2011.ornl.gov Chair: Dr Malcolm Stocks (ORNL) Vice Chairs: Adriana Moreo (ORNL/UT) James Guberrnatis (LANL) Local Program Committee: Don Batchelor (ORNL) Jack Dongarra (UTK/ORNL) James Hack (ORNL) Robert Harrison (ORNL) Paul Kent (ORNL) Anthony Mezzacappa (ORNL) Adriana Moreo (ORNL) Witold Nazarewicz (UT) Loukas Petridis (ORNL) David Schultz (ORNL) Bill Shelton (ORNL) Claudia Troparevsky (ORNL) Mina Yoon (ORNL) International Advisory Board Members: Joan Adler (Israel Institute of Technology, Israel) Constantia Alexandrou (University of Cyprus, Cyprus) Claudia Ambrosch-Draxl (University of Leoben, Austria) Amanda Barnard (CSIRO, Australia) Peter Borcherds (University of Birmingham, UK) Klaus Cappelle (UFABC, Brazil) Giovanni Ciccotti (Università degli Studi di Roma 'La Sapienza', Italy) Nithaya Chetty (University of Pretoria, South Africa) Charlotte Froese-Fischer (NIST, US) Giulia A. Galli (University of California, Davis, US) Gillian Gehring (University of Sheffield, UK) Guang-Yu Guo (National Taiwan University, Taiwan) Sharon Hammes-Schiffer (Penn State, US) Alex Hansen (Norweigan UST) Duane D. Johnson (University of Illinois at Urbana-Champaign, US) David Landau (University of Georgia, US) Joaquin Marro (University of Granada, Spain) Richard Martin (UIUC, US) Todd Martinez (Stanford University, US) Bill

  4. EXPERIÊNCIA E FORMAÇÃO DOCENTE DE PROFESSORES QUE ENSINAM MATEMÁTICA. EDUCATION AND EXPERIENCE OF MATHEMATICS TEACHERS

    Directory of Open Access Journals (Sweden)

    Oliveira, Cláudio José de

    2012-05-01

    Full Text Available Este texto apresenta e discute os resultados finais de uma pesquisa que estudou a formação docente de egressos dos Cursos de Pedagogia, no período de 1995 até o ano de 2008, em relação aos processos de aprender e ensinar matemática nos Anos Iniciais do Ensino Fundamental (AIEF. A pesquisa também estudou a experiência de formação de estudantes-professoras matriculadas nas disciplinas de Linguagem Matemática na Educação I e II, nas edições de 2009 até 2011. Assim, o objetivo deste texto é discutir alguns efeitos da formação como experiência docente na produção de professores segundo uma lógica da informação, do repassar conteúdo e da formação de sujeitos da opinião. A produção dos dados foi realizada em duas etapas. Na primeira foi realizado um mapeamento dos egressos dos Cursos de Pedagogia que responderam dois questionários com questões objetivas e dissertativas. A tabulação e análise dos dados foram realizadas com as estudantes-professoras durante as disciplinas. Fez parte da segunda etapa um fórum de discussão na modalidade EAD. Na primeira etapa da pesquisa 40 egressos de Pedagogia responderam aos questionários e, na segunda, 30 alunas participaram do fórum de discussão. Os achados da pesquisa foram discutidos problematizando a formação docente como produtora de um professor informado de técnicas, um sujeito que tem pressa, que busca conhecer no tempo que dispõe as novidades apresentadas na e pela instituição formadora. Como resultados sublinhamos a intrínseca relação entre os saberes docentes e as práticas pedagógicas dos professores que ensinam matemática com as propostas dos “cursos de atualização” que lhes são oferecidos, impostos, sem avaliar os resultados destas ações. Na análise dos dados foram considerados os estudos de Maurice Tardif, Dario Fiorentini, Adair Nacarato, Jorge Larrosa, entre outros.This paper presents and discusses the final results of a research that

  5. II Luso-Brazilian Symposium - Hair Care and Health Proceedings

    Directory of Open Access Journals (Sweden)

    Joana Portugal Mota et al.

    2014-12-01

    Full Text Available II Luso-Brazilian Symposium - Hair Care and Health II Simpósio Luso-Brasileiro - Cuidados e Saúde do Cabelo 24 October | 24 Outubro Lisboa - Universidade Lusófona Honor Commitee /Comissão de Honra Magnífico Reitor da Universidade Lusófona, Mário Moutinho Presidente do Conselho de Administração da Universidade Lusófona, Manuel de Almeida Damásio Presidente do Infarmed, Eurico Castro Alves. Bastonário da Ordem dos Farmacêuticos, Carlos Maurício Barbosa Presidente da Associação Industriais Cosmética, Ana Maria Couras. Presidente da SPCC, Luís Monteiro Rodrigues (Presidente do Simpósio Presidente da ABC, João Hansen (Presidente do Simpósio Scientific Commitee /Comissão Científica Alberto Keidi Kurebayashi Catarina Fialho Rosado Celso Martins Júnior Joana Portugal Mota João Hansen Luís Monteiro Rodrigues Maria Lídia Palma Organizing Commitee /Comissão Organizadora SPCC Escola de Ciências e Tecnologias da Saúde (ECTS da U. Lusófona de Humanidades e Tecnologias ALIES – Associação Lusófona para o Desenvolvimento do Ensino e Investigação das Ciências da Saúde CBIOS – Centro de Investigação em Biociências e Tecnologias da Saúde Programa Open Session | Sessão de abertura Bastonário da Ordem dos Farmacêuticos, Carlos Maurício Barbosa Direcção da SPCC, Manuel Fitas Direcção da ABT, Celso Martins Júnior 1st Session | Sessão 1 HOT TOPICS (Tecnologia das Formulações Charmain | Moderador - Joana Portugal Mota Speakers | Prelectores Celso Martins Júnior Michelli Dario Key-note Speakers | Prelectores Bruno A. Bernard Nelson Tavares 2st Session | Sessão 2 HOT TOPICS (Saúde do Cabelo e Imagem Charmain | Moderador - André Rolim Baby Speakers | Prelectores Celso Martins Júnior Roundtable - Debate | Mesa Redonda - Debate Flávio Roques Catarina Rosado Previous speakers | Prelectores anteriores 1st Session | Sessão 1 HOT TOPICS (Formulation Technology | HOT TOPICS (Tecnologia das Formulações Chairman

  6. Palavras do editor

    Directory of Open Access Journals (Sweden)

    Nelkis de la Orden Medina

    2005-06-01

    Full Text Available É com satisfação que apresentamos a edição 5 da Revista Eletrônica de Sistemas de Informação. Os trabalhos apresentados constituem um meio de divulgação das pesquisas e reflexões sobre diferentes temáticas da área de informática. Fazem parte desta edição cinco artigos, abordando assuntos relacionados à multimídia, gestão do conhecimento, gestão de projetos e informática aplicada à medicina. Rogério Kinape e Mardson Amorim nos trazem o artigo “A study of the most important image quality measures” que apresenta uma discussão sobre as medidas de qualidade de imagem quanto ao seu desempenho. Andréa Sabedra Bordin e Renato Balancieri são os autores do trabalho “Proposta de uma Arquitetura de Agentes Móveis para Recuperação de Informação Útil e Distribuída no Processo de Gestão do Conhecimento”, no qual apresentam uma proposta para a utilização de uma arquitetura de agentes móveis no processo de gestão do conhecimento. No artigo “Técnicas de Animação em Ambientes Tridimensionais” os autores Walter Dutra da Silveira Neto e Adrei Krepsky apresentam um estudo dos princípios fundamentais de animação aplicados a um ambiente virtual de animação tridimensional. O artigo “Limitações das Atuais Soluções em Software: Uma Visão para Desenvolvimento de Ferramentas em Gestão de Projetos” dos autores Dani Juliano Czelusniak, Alessandro de Oliveira Binhara, Carlos Eduardo Yamasaki Sato, Dario Eduardo do Amaral Dergint e Luiz Alberto Pilatti apresenta um estudo que visa verificar as atuais limitações dos softwares de auxílio ao gestor de projetos, demonstrando como novas tecnologias de desenvolvimento de software podem contribuir para a construção de ferramentas mais eficazes. O quinto artigo de Osmir Kmeteuk Filho e Carolina Richter Anacleto, “Telemedicina: possibilidades versus realidade” apresenta um estudo das necessidades tecnológicas para a aplicação da telemedicina. Estes artigos

  7. PREFACE: Rutherford Centennial Conference on Nuclear Physics

    Science.gov (United States)

    Freeman, Sean

    2012-09-01

    Dobacewski (Warsaw, Poland) G Dracoulis (ANU, Australia) S J Freedman (LBL, USA) M Hass (Weizmann Institute, Israel) M Huyse (Leuven, Belgium) P Jones (Birmingham, UK) D Khao (Hanoi, Vietnam) R Krücken (Munich, Germany) K Langanke (Darmstadt, Germany) C Lister (Argonne, USA) G A Miller (University of Washington, USA) D Morrissey (MSU, USA) T Motobayashi (RIKEN, Japan) S Nagamiya (J-PARC, Japan) W Nazarewicz (ORNL, USA) S Mullins (iThemba, South Africa) T Nakamura (Tokyo, Japan) P Roussel Chomaz (GANIL, France) R Ribas (Sao Paolo, Brazil) M Vanderhaeghen (Mainz, Germany) U Wiedner (Uppsala, Sweden) F Xu (Peking University, China) Q Zhao (IHEP, Bejing) W Zajc (Columbia, USA)

  8. Correlations between immunogenicity, drug levels, and disease activity in an Italian cohort of rheumatoid arthritis patients treated with tocilizumab

    Directory of Open Access Journals (Sweden)

    Benucci M

    2016-03-01

    Full Text Available Maurizio Benucci,1 Francesca Meacci,2 Valentina Grossi,2 Maria Infantino,2 Mariangela Manfredi,2 Emanuele Bellio,2 Valerio Bellio,2 Francesca Li Gobbi,1 Laura Bazzichi,3 Paolo Moscato,4 Dario Caputo,4 Gianantonio Saviola,5 Rossella Talotta,6 Piercarlo Sarzi-Puttini,6 Fabiola Atzeni71Rheumatology Unit, Ospedale San Giovanni di Dio, Florence, Italy; 2Allergology and Immunology Laboratory, Ospedale San Giovanni di Dio, Florence, Italy; 3Rheumatology Unit, University of Pisa, Pisa, Italy; 4Internal Medicine and Rheumatology Unit, University of Salerno, Salerno, Italy; 5Rheumatology Unit, Salvatore Maugeri Foundation, Mantua, Italy; 6Rheumatology Unit, Ospedale Luigi Sacco, Milan, Italy; 7IRCCS Galeazzi Orthopedic Institute, Milan, ItalyAbstract: The aim of this study was to evaluate the real-life immunogenicity of anti-drug antibodies, drug levels, and disease activity in an Italian cohort of rheumatoid arthritis patients treated with tocilizumab (TCZ. We evaluated 126 TCZ-treated patients with rheumatoid arthritis (16 males and 110 females; mean age 59±12 years, range 26–83; mean disease duration 11±5 years with inadequate 12-week response to any synthetic and biological disease-modifying anti-rheumatic drugs, in a retrospective analysis. One-hundred and seven patients were treated with methotrexate mean dose 12.6±1.3 mg/week in combination with TCZ, 13 received TCZ monotherapy, and six received leflunomide 20 mg/day plus TCZ; all patients were treated with prednisone mean dose 6.4±1.2 mg/day. They had a 28-joint Disease Activity Score (DAS28 of >3.2, an erythrocyte sedimentation rate (ESR of >30 mm/hour, and CRP levels of >1.0 mg/dL. We evaluated at baseline and after 6 months of treatment: DAS28; rheumatoid factor (RF IgM, IgA, and IgG; anti-citrullinated peptide antibody; ESR; CRP; TNF-α; and IL-6. TCZ and anti-TCZ antibodies were detected using LISA-TRACKER Duo TCZ. TCZ levels of <10 µg/mL were considered low and >10 µg/mL high. After

  9. Escola e cotidiano: um estudo das percepções matemáticas da comunidade quilombola Mussuca, em Sergipe

    Directory of Open Access Journals (Sweden)

    Evanilson Tavares de França

    2015-06-01

    Full Text Available Como ensina Ubiratan D’Ambrósio, a disciplina tão valorizada e que, muitas vezes, é colocada no pódio máximo quando se estabelece escalonamento das disciplinas é, em verdade, uma Etnomatemática produzida na Europa mediterrânea com algumas contribuições do povo indiano e da civilização islâmica. A universalização desta Etnomatemática terminou eclipsando as construções matemáticas de outros grupos humanos, inclusive dos quilombolas. Esta postura hegemônica impulsionou o desenvolvimento desta pesquisa no quilombo Mussuca, localizado no município de Laranjeiras (Sergipe – Brasil, no período de maio/2012 a março/2013, objetivando analisar as percepções sobre os saberes matemáticos apresentadas por estudantes do 5º ano do Ensino Fundamental da comunidade quilombola (Mussuca e a relação estabelecida por estes/as estudantes, professoras polivalentes e gestores/as da escola municipal com estes mesmos saberes e com a relação deles com as africanidades. As referências teóricas sustentadoras desta pesquisa estão representadas pela compreensão de: a quilombo, tendo José Maurício Andion Arruti e Eliane Cantarino O’Dwyer como principais interlocutores/as; b panorama da aprendizagem matemática, a partir das reflexões de Veleida Anahi da Silva, Shirley Conceição Silva da Costa, Ubiratan D’Ambrósio, Dario Fiorentini, Sérgio Lorenzato e Antônio Miguel, dentre outros; c Etnomatemática, alicerçada, principalmente, nas construções de Ubiratan D’Ambrósio. As africanidades também constituíram diálogos frequentes, tendo em Maria Batista Lima e Azoilda Loretto Trindade seus principais aportes. O caminho delineado para a construção da pesquisa amparou-se em abordagem qualitativa por tratar o objeto de estudo de maneira globalizada, observando todos os elementos que interferem e que com ele dialogam. Como procedimentos metodológicos, recorreu-se a questionários, entrevistas semiestruturadas, observação n

  10. PREFACE: International Conference on Computing in High Energy and Nuclear Physics (CHEP 2010)

    Science.gov (United States)

    Lin, Simon C.; Shen, Stella; Neufeld, Niko; Gutsche, Oliver; Cattaneo, Marco; Fisk, Ian; Panzer-Steindel, Bernd; Di Meglio, Alberto; Lokajicek, Milos

    2011-12-01

    , as well as two banquets held at the Grand Hotel and Grand Formosa Regent in Taipei. The next CHEP conference will be held in New York, the United States on 21-25 May 2012. We would like to thank the National Science Council of Taiwan, the EU ACEOLE project, commercial sponsors, and the International Advisory Committee and the Programme Committee members for all their support and help. Special thanks to the Programme Committee members for their careful choice of conference contributions and enormous effort in reviewing and editing about 340 post conference proceedings papers. Simon C Lin CHEP 2010 Conference Chair and Proceedings Editor Taipei, Taiwan November 2011 Track Editors/ Programme Committee Chair Simon C Lin, Academia Sinica, Taiwan Online Computing Track Y H Chang, National Central University, Taiwan Harry Cheung, Fermilab, USA Niko Neufeld, CERN, Switzerland Event Processing Track Fabio Cossutti, INFN Trieste, Italy Oliver Gutsche, Fermilab, USA Ryosuke Itoh, KEK, Japan Software Engineering, Data Stores, and Databases Track Marco Cattaneo, CERN, Switzerland Gang Chen, Chinese Academy of Sciences, China Stefan Roiser, CERN, Switzerland Distributed Processing and Analysis Track Kai-Feng Chen, National Taiwan University, Taiwan Ulrik Egede, Imperial College London, UK Ian Fisk, Fermilab, USA Fons Rademakers, CERN, Switzerland Torre Wenaus, BNL, USA Computing Fabrics and Networking Technologies Track Harvey Newman, Caltech, USA Bernd Panzer-Steindel, CERN, Switzerland Antonio Wong, BNL, USA Ian Fisk, Fermilab, USA Niko Neufeld, CERN, Switzerland Grid and Cloud Middleware Track Alberto Di Meglio, CERN, Switzerland Markus Schulz, CERN, Switzerland Collaborative Tools Track Joao Correia Fernandes, CERN, Switzerland Philippe Galvez, Caltech, USA Milos Lokajicek, FZU Prague, Czech Republic International Advisory Committee Chair: Simon C. Lin , Academia Sinica, Taiwan Members: Mohammad Al-Turany , FAIR, Germany Sunanda Banerjee, Fermilab, USA Dario Barberis, CERN

  11. PREFACE: Workshop Photograph and Program

    Science.gov (United States)

    2011-07-01

    : Bonnie Fleming (Yale U.))18:30 Supernovae neutrino detection (20') Ines Gil-Botella (CIEMAT)18:50 Neutrino cross-section in Liquid Argon in the GeV range (15') Flavio Cavanna (U. of L'Aquila)19:05 Analysis of the ArgoNeuT neutrino data (15') Carl Bromberg (Michigan State U.)19:20 Neutrino event reconstruction (15') Gary Barker (U. of Warwick) Tuesday 30 March 2010Ways to improve the Liquid Argon Charge Imaging technology I (Chair: Christos Touramanis (U. of Liverpool))09:00 Liquid Argon LEM TPC (30') Filippo Resnati (ETH Zurich)09:30 Micromegas for charge readout of double phase liquid Argon large TPCs (20') Alain Delbart (Saclay)09:50 Development of Thick-GEMs for GEM-TPC Tracker (20') Fuminori Sakuma (RIKEN)10:10 Optical readout of the ionization (20') Neil Spooner (U. of Sheffield)10:30 Scintillation light readout (20') Kostas Mavrokoridis (U. of Liverpool)10:50-11:10 Coffee break Ways to improve the Liquid Argon Charge Imaging technology II (Chair: Alberto Marchionni (ETH Zurich))11:10 Development of cold electronics (30') Veljko Radeka (BNL)11:40 Development of a frontend ASIC and DAQ system Dario Autiero (IPN Lyon)12:00 CAEN digitizers (20') Carlo Tintori (CAEN)12:20 Recent results from Liquid Argon R&D activity (20') Masashi Tanaka (KEK)12:40 Results from the materials test stand and status of LAPD (20') Brian Rebel (FNAL)13:00 Purging and purification: 6 m3 @CERN (20') Alessandro Curioni (ETH Zurich)13:20-14:30 Lunch break14:30-20:00 Trip to J-PARC to visit T2K Beam Facility and Near Detector20:00-22:00 Workshop dinner at Okura Frontier Hotel Tsukuba Wednesday 31 March 2010Ways to improve the Liquid Argon Charge Imaging technology III (Chair: Takasumi Maruyama (KEK))09:00 ArgonTube and UV laser ionization (25') Biagio Rossi (U. of Bern)09:25 Detector magnetization (15') Andreas Badertscher (ETH Zurich)09:40 HV system (25') Sosuke Horikawa (ETH Zurich) Localization studies (Chair: Takuya Hasegawa (KEK))10:05 Okinoshima site study (20') Masakazu Yoshioka (KEK)10

  12. PREFACE: Loops 11: Non-Perturbative / Background Independent Quantum Gravity

    Science.gov (United States)

    Mena Marugán, Guillermo A.; Barbero G, J. Fernando; Garay, Luis J.; Villaseñor, Eduardo J. S.; Olmedo, Javier

    2012-05-01

    only was it a showroom for the research currently being carried out by many groups throughout the world, but there was also a permanent look towards the future. During these days, the CSIC Campus witnessed many scientific conversations triggered by the interaction amongst the people and groups that participated in LOOPS'11 Madrid and which, in many cases, will crystallise into new results and advances in the field. The conference would not have been possible without the generous help of a number of national and international institutions. The organizers would like to acknowledge the financial support provided by the Spanish Ministry of Science and Innovation (Ministerio de Ciencia e Innovación), the Spanish Research Council, CSIC (Consejo Superior de Investigaciones Cientĺficas), The BBVA Foundation (Fundación BBVA), The CONSOLIDER-CPAN project, the Spanish Society for Gravitation and Relativity (SEGRE), The Universidad Carlos III of Madrid (UC3M), and the European Science Foundation (ESF). The ESF, through the Quantum Gravity and Quantum Geometry network, provided full support for a number of young participants that have contributed to these proceedings: Dario Benedetti (Albert Einstein Institute, Potsdam, Germany), Norbert Bodendorfer (Institute for Theoretical Physics III, FAU Erlangen Nürnberg, Germany), Mariam Bouhmadi López (CENTRA, Centro Multidisciplinar de Astrofĺsica, Lisbon), Timothy Budd (Institute for Theoretical Physics, Utrecht University, The Netherlands), Miguel Campiglia (Institute for Gravitation and the Cosmos, Penn State University, USA), Gianluca Delfino (School of Mathematical Sciences, University of Nottingham, UK), Maite Dupuis (Institute for Theoretical Physics III, FAU Erlangen Nürnberg, Germany), Michał Dziendzikowski (Institute of Theoretical Physics, Warsaw University, Poland), Muxin Han (Centre de Physique Théorique de Luminy, Marseille, France), Philipp Höhn (Institute for Theoretical Physics, Utrecht University, The

  13. PREFACE: First Mediterranean Conference on Classical and Quantum Gravity (MCCQG 2009)

    Science.gov (United States)

    Basilakos, Spyros; Cadoni, Mariano; Cavaglia, Marco; Christodoulakis, Theodosios; Vagenas, Elias C.

    2010-04-01

    Fisica, Universidade de Sao Paulo, Brasil) Antoniadis, Ignatios (CERN, Geneva, Switzerland) Arminjon, Mayeul (CNRS, Section of Theoretical Physics, France) Banados, Max (University of Oxford, UK) Basilakos, Spyros (RCAAM, Academy of Athens, Greece) Bastos, Catarina (IST, Departamento de Física, Portugal) Bertolami, Orfeu (IST, Departamento de Física, Portugal) Bevilaqua, Leandro Ibiapina (Instituto de Fisica, Universidade de Sao Paulo, Brazil) Bezerra De Mello, Eugenio (Dept. de Física, CCEN Universidade Federal da Paraíba, Brazil) Blake, Russ (Readify Pty Ltd, Australia) Bogdanos, Charalampos (LPT-Orsay, France) Burinskii, Alexander (Gravity Research Group NSI, Russian Academy of Sciences, Russia) Cadonati, Laura (University of Massachusetts, Amherst, USA) Cadoni, Mariano (Università di Cagliari, Italy) Capone, Monica (University of Turin, Italy) Cavaglià, Marco (University of Mississippi, USA) Chirco, Goffredo (SISSA-International School for Advanced Studies, Italy) Christodoulakis, Theodosios (University of Athens, Greece) Domingues Zarro, Carlos Augusto ((IST, Departamento de Física, Portugal) Durrer, Ruth (Université de Genève, Département de Physique Théorique, Switzerland) Fagnocchi, Serena (SISSA-International School for Advanced Studies, Italy) Finazzi, Stefano (SISSA-International School for Advanced Studies, Italy) Francia, Dario (University Paris 7 - APC, France) Ghosh, Subir (Indian Statistical Institute, India) Gomberoff, Andres (Universidad Catolica de Chile, Chile) Grumiller, Daniel (Institute for Theoretical Physics Vienna University of Technology, Austria) Herrera-Aguilar, Alfredo (IFM, Universidad Michoacana de San Nicolas de Hidalgo, Mexico) Hsu, Steve (University of Oregon, USA) Ichinose, Shoichi (University of Shizuoka, SFNS, Japan) Kiefer, Claus (Institute for Theoretical Physics, University of Cologne, Germany) Kokkotas, Kostas (Theoretical Astrophysics, Eberhard Karls University of Tuebingen, Germany) Kothawala, Dawood (IUCAA, Pune

  14. PREFACE New developments in nanopore research—from fundamentals to applications New developments in nanopore research—from fundamentals to applications

    Science.gov (United States)

    Albrecht, Tim; Edel, Joshua B.; Winterhalter, Mathias

    2010-11-01

    , Di Cao and Stuart Lindsay Probing DNA with micro- and nanocapillaries and optical tweezers L J Steinbock, O Otto, D R Skarstam, S Jahn, C Chimerel, J L Gornall and U F Keyser Fabrication of nanopores with embedded annular electrodes and transverse carbon nanotube electrodes Zhijun Jiang, Mirna Mihovilovic, Jason Chan and Derek Stein Fabrication and electrical characterization of a pore-cavity-pore device D Pedone, M Langecker, A M Münzer, R Wei, R D Nagel and U Rant Use of tunable nanopore blockade rates to investigate colloidal dispersions G R Willmott, R Vogel, S S C Yu, L G Groenewegen, G S Roberts, D Kozak, W Anderson and M Trau Facilitated translocation of polypeptides through a single nanopore Robert Bikwemu, Aaron J Wolfe, Xiangjun Xing and Liviu Movileanu Mechanistic insight into gramicidin-based detection of protein-ligand interactions via sensitized photoinactivation Tatyana I Rokitskaya, Michael X Macrae, Steven Blake, Natalya S Egorova, Elena A Kotova, Jerry Yang and Yuri N Antonenko Sequence-dependent unfolding kinetics of DNA hairpins studied by nanopore force spectroscopy Stephan Renner, Andrey Bessonov, Ulrich Gerland and Friedrich C Simmel Hydration properties of mechanosensitive channel pores define the energetics of gating A Anishkin, B Akitake, K Kamaraju, C-S Chiang and S Sukharev Dynamic translocation of ligand-complexed DNA through solid-state nanopores with optical tweezers Andy Sischka, Andre Spiering, Maryam Khaksar, Miriam Laxa, Janine König, Karl-Josef Dietz and Dario Anselmetti Force fluctuations assist nanopore unzipping of DNA V Viasnoff, N Chiaruttini, J Muzard and U Bockelmann Control and reversal of the electrophoretic force on DNA in a charged nanopore Binquan Luan and Aleksei Aksimentiev The properties of the outer membrane localized Lipid A transporter LptD Raimund Haarmann, Mohamed Ibrahim, Mara Stevanovic, Rolf Bredemeier and Enrico Schleiff Structural and dynamical properties of the porins OmpF and OmpC: insights from

  15. Sensing at the nanoscale

    Science.gov (United States)

    Demming, Anna; Hierold, Christofer

    2013-11-01

    The merits of nanostructures in sensing may seem obvious, yet playing these attributes to their maximum advantage can be a work of genius. As fast as sensing technology is improving, expectations are growing, with demands for cheaper devices with higher sensitivities and an ever increasing range of functionalities and compatibilities. At the same time tough scientific challenges like low power operation, noise and low selectivity are keeping researchers busy. This special issue on sensing at the nanoscale with guest editor Christofer Hierold from ETH Zurich features some of the latest developments in sensing research pushing at the limits of current capabilities. Cheap and easy fabrication is a top priority. Among the most popular nanomaterials in sensing are ZnO nanowires and in this issue Dario Zappa and colleagues at Brescia University in Italy simplify an already cheap and efficient synthesis method, demonstrating ZnO nanowire fabrication directly onto silicon substrates [1]. Meanwhile Nicolae Barson and colleagues in Germany point out the advantages of flame spray pyrolysis fabrication in a topical review [2] and, maximizing on existing resources, researchers in Denmark and Taiwan report cantilever sensing using a US20 commercial DVD-ROM optical pickup unit as the readout source [3]. The sensor is designed to detect physiological concentrations of soluble urokinase plasminogen activator receptor, a protein associated with inflammation due to HIV, cancer and other infectious diseases. With their extreme properties carbon nanostructures feature prominently in the issue, including the demonstration of a versatile and flexible carbon nanotube strain sensor [4] and a graphene charge sensor with sensitivities of the order of 1.3 × 10-3 e Hz-1/2 [5]. The issue of patterning for sensing devices is also tackled by researchers in the US who demonstrate a novel approach for multicomponent pattering metal/metal oxide nanoparticles on graphene [6]. Changes in electrical

  16. PREFACE: Fourth Meeting on Constrained Dynamics and Quantum Gravity

    Science.gov (United States)

    Cadoni, Mariano; Cavaglia, Marco; Nelson, Jeanette E.

    2006-04-01

    Cagliari, Italy) Roberto De Pietri (Università di Parma, Italy) Giuseppe De Risi (Università di Bari, Italy) Hans-Thomas Elze (Univ. Federal do Rio de Janeiro, Brasil) Alessandro Fabbri (Università di Bologna, Italy) Sergey Fadeev (VNIIMS, Moscow, Russia) Serena Fagnocchi (Università di Bologna, Italy) Sara Farese (Universidad de Valencia, Spain) Alessandra Feo (Università di Parma, Italy) Dario Francia (Università di Roma Tor Vergata, Italy) Francesco Fucito (Università di Roma Tor Vergata, Italy) Dmitri Fursaev (JINR, Dubna, Russia) Daniel Galehouse (University of Akron, Ohio, USA) Remo Garattini (Università di Bergamo, Italy) Florian Girelli (Perimeter Institute, Waterloo, Canada) Luca Griguolo (Università di Parma, Italy) Daniel Grumiller (Universität Leipzig, Germany) Shinichi Horata (Hayama Center of Advanced Research, Japan) Giorgio Immirzi (Università di Perugia, Italy) Roman Jackiw (MIT, Cambridge, USA) Matyas Karadi (DAMTP, University of Cambridge, UK) Mikhail Katanaev (Steklov Mathematical Institute, Moscow, Russia) Claus Kiefer (Universität Koln, Germany) John Klauder (University of Florida, Gainesville, USA) Pavel Klepac (Masaryk University, Brno, Czech Republic) Jen-Chi Lee (National Chiao-Tung University, Taiwan) Carlos Leiva (Universidad de Tarapacá, Arica, Chile) Stefano Liberati (SISSA/ISAS, Trieste, Italy) Jorma Louko (University of Nottingham, UK) Luca Lusanna (INFN, Sezione di Firenze, Italy) Roy Maartens (University of Portsmouth, UK) Fotini Markopoulou (Perimeter Institute, Waterloo, Canada) Annalisa Marzuoli (Università di Pavia, Italy) Evangelos Melas (QMW, University of London, UK) Maurizio Melis (Università di Cagliary, Italy) Vitaly Melnikov (VNIIMS, Moscow, Russia) Guillermo A. Mena Marugan (CSIC, Madrid, Spain) Pietro Menotti (Università di Pisa, Italy) Salvatore Mignemi (Università di Cagliari, Italy) Aleksandar Mikovic (Universidade Lusófona, Lisboa, Portugal) Leonardo Modesto (Université de la Mediterranée, Marseille