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Sample records for natrium-iodid-symporter nis bedeutung

  1. Molecular and structural characterisation of the human sodium/iodide symporter (h N.I.S.) C-terminus and the implication of this domain in the transporter regulation; Caracterisation moleculaire et structurale de l'extremite C-Terminale du co-transporteur sodium/iode humain (h N.I.S.): Implication de ce domaine dans la regulation du transporteur

    Energy Technology Data Exchange (ETDEWEB)

    Huc, S

    2007-12-15

    The human natrium iodide symporter (h N.I.S.) is an intrinsic membrane protein expressed in thyroid cells where it allows iodide uptake and accumulation. It is composed of thirteen transmembrane helices and its ninety- three amino acids long cytosolic C-terminus presents many potential post-translational regulatory sites. A first part of the PhD work has been dedicated to the expression in a bacterial system and to the purification of the cytosolic C-terminal fragment. Biochemical and structural characterisation have revealed that this C-terminus is very flexible but prone to dimerization. The fragment has also been used as a bait to test the interactions with PDZ domain proteins spotted on a membrane. Several proteins interacting with the (natrium/iodide symporter) N.I.S. C-terminus have thus been identified and the study of their implication in the protein regulation has been initiated. A second part of the work has underlined the existence of a N.I.S. fragment co-purified with the entire protein. This fragment has been found in cells in culture stably expressing N.I.S. and also in human thyroid extracts and in rodent thyroid cells. We observed that this fragment is spontaneously associated with the entire protein. It is composed of the last 131 amino acid of the protein and so comprises the last transmembrane domain and the C-terminal extremity. The expression of a truncated form of h N.I.S., lacking the last 131 amino acids, shows that this protein is not correctly addressed to the cell membrane and cells expressing this mutated symporter cannot accumulate iodide. However, our results show that the co-expression of the two N.I.S. parts, the truncated form lacking the last 131 amino acid, and the complementary C-terminal fragment, leads to cells presenting 10 % of the activity of cells expressing the whole N.I.S.. (author)

  2. Molecular and structural characterisation of the human sodium/iodide symporter (h N.I.S.) C-terminus and the implication of this domain in the transporter regulation

    International Nuclear Information System (INIS)

    Huc, S.

    2007-12-01

    The human natrium iodide symporter (h N.I.S.) is an intrinsic membrane protein expressed in thyroid cells where it allows iodide uptake and accumulation. It is composed of thirteen transmembrane helices and its ninety- three amino acids long cytosolic C-terminus presents many potential post-translational regulatory sites. A first part of the PhD work has been dedicated to the expression in a bacterial system and to the purification of the cytosolic C-terminal fragment. Biochemical and structural characterisation have revealed that this C-terminus is very flexible but prone to dimerization. The fragment has also been used as a bait to test the interactions with PDZ domain proteins spotted on a membrane. Several proteins interacting with the (natrium/iodide symporter) N.I.S. C-terminus have thus been identified and the study of their implication in the protein regulation has been initiated. A second part of the work has underlined the existence of a N.I.S. fragment co-purified with the entire protein. This fragment has been found in cells in culture stably expressing N.I.S. and also in human thyroid extracts and in rodent thyroid cells. We observed that this fragment is spontaneously associated with the entire protein. It is composed of the last 131 amino acid of the protein and so comprises the last transmembrane domain and the C-terminal extremity. The expression of a truncated form of h N.I.S., lacking the last 131 amino acids, shows that this protein is not correctly addressed to the cell membrane and cells expressing this mutated symporter cannot accumulate iodide. However, our results show that the co-expression of the two N.I.S. parts, the truncated form lacking the last 131 amino acid, and the complementary C-terminal fragment, leads to cells presenting 10 % of the activity of cells expressing the whole N.I.S.. (author)

  3. Bedeutung von Umwelt- und Organismusfaktoren bei Autoaggressionen

    OpenAIRE

    Rohmann, Ulrich H.; Elbing, Ulrich; Hartmann, Hellmut

    1988-01-01

    In der vorliegenden Arbeit werden übergeordnete Hypothesen zu autoaggressiven Verhaltensweisen formuliert, wobei prozeßhafte Abläufe von umweltbezogenen und organischen Variablen angenommen werden. Eine solche dynamische Beziehung hat ihre Bedeutung sowohl für verursachende als auch aufrechterhaltende Faktoren. In einer Querschnittuntersuchung lassen sich Korrelationen von Tageszeit- und Tätigkeitscharakteristiken (umweltbezogene Variablen) zur Autoaggressionshäufigkeit und Pulsfrequenz (Orga...

  4. FOUNDING OF THE DISTRICT HOSPITAL IN NIS

    Directory of Open Access Journals (Sweden)

    Misa Zivic

    2007-01-01

    Full Text Available After the liberation of Nis from the Turks which took place on January 11th, 1878, there were two military hospitals: one was next to The Skull Tower and the other on the road to Leskovac and there was Islahana the civil institution which was not the forerunner of the district hospital in Nis. At first, they founded the military hospital in Nis in 1878 and then they founded The District Hospital on July 17th in 1881. The first director of the District hospital was Anton Zajicek. He is also the first graduated medical doctor in Nis. The District Hospital was situated on the left bank of the Nisava river in a private house.

  5. Training builds organizations in NIS.

    Science.gov (United States)

    1995-01-01

    The Centre for Development and Population Activities (CEDPA) has been using workshops to train nongovernmental organization (NGOs) managers in the Newly Independent States (NIS) of the former Soviet Union over the past year (1994). 7 were held in Ukraine and Moldova (with support from the Counterpart Foundation under an agreement with the US Agency for International Development), that covered skills for effective training and project proposal writing. The managers represented a variety of fields: environment, health, family planning, social services, consumer affairs, youth needs, women's programs, disabilities, education, and culture. Ralph Stone is CEDPA training director. Adrienne Allison, vice president of CEDPA, is a member of the Volunteer Executive Service Team (VEST), which conducts study tours to the area. A collaborative effort of the US government and the US private sector, VEST supports the development of the independent, civil, and services sectors of the new countries. In Washington, CEDPA conducted workshops on women's reproductive health (February and March) and on business policy and regulation (November and December) for Russians involved in family planning and small business development respectively. These were organized in conjunction with the University of California at Riverside and the Academy for Educational Development.

  6. [Genetic aspects in congenital hypothyrodism].

    Science.gov (United States)

    Perone, Denise; Teixeira, Silvânia S; Clara, Sueli A; Santos, Daniela C dos; Nogueira, Célia R

    2004-02-01

    Congenital hypothyroidism (CH) affects between 1:3,000 and 1:4,000 newborns. Many genes are essential for normal development of the hypothalamus-pituitary-thyroid axis and hormone production, and are associated with CH. About 85% of primary hypothyroidism is called thyroid digenesis and evidence suggests that mutations in transcription factors (TTF2, TTF1, and PAX-8) and TSH receptor gene could be responsible for the disease. Genetic defects of hormone synthesis could be caused by mutations in the following genes: NIS (natrium-iodide symporter), pendrine, thyreoglobulin (TG), peroxidase (TPO). Recently, mutations in the THOX-2 gene have also been related to organification defects. Central hypothyroidism affects about 1:20,000 newborns and has been associated with mutations in pituitary transcriptional factors (POUIF1, PROP1, LHX3, and HESX1). The syndrome of resistance to thyroid hormone is rare, implies a hypothyroidism state for some tissues and is frequently associated with dominant autosomal mutations in the beta-receptor (TRss).

  7. Die Bedeutung des Knochenstoffwechsel-Biomarker in der Osteologie 2012

    Directory of Open Access Journals (Sweden)

    Obermayer-Pietsch B

    2012-01-01

    Full Text Available In den vergangenen Jahren wurden zahlreiche Moleküle aus unterschiedlichen Knochenstoffwechselwegen – so genannte „Knochenbiomarker“ – identifiziert. Sowohl Serum und Plasma als auch Harnanalysen werden für klinische Messungen des Knochenstoffwechsels herangezogen, wobei die Genauigkeit und Nutzerfreundlichkeit Blutproben deutlich bevorzugt. Die systemische Messbarkeit dieser Labormarker außerhalb des Knochens dient dabei als Basis für einen aktuellen „Schnappschuss“ des Knochenstoffwechsels. Die Bedeutung der Knochenbiomarker 2012 liegt in der zunehmend ganzheitlichen Betrachtung von Knochenerkrankungen, wobei einzelne morphologische Messungen wie die Dual-Energie- Röntgenabsorptiometrie (DXA nicht mehr als einzige Methode zur Knochenbeurteilung herangezogen werden. Eine internationale Standardisierung der wichtigsten Knochenmarker zur besseren Vergleichbarkeit ist bereits im Laufen. Eine vereinfachte technische Umsetzung soll in den nächsten Jahren auch weniger spezialisierte Labors und Point-of-Care-Tests einschließen, wobei neue Erkenntnisse aus der Präanalytik von Bedeutung sind. Ob sich Knochenbiomarker in Zukunft weiter durchsetzen werden, hängt allerdings nicht nur von wissenschaftlichen und medizintechnischen, sondern auch von ökonomischen und demographischen Umständen ab.

  8. Die Bedeutung des Knochenstoffwechsel-Biomarker in der Osteologie 2012

    Directory of Open Access Journals (Sweden)

    Obermayer-Pietsch B

    2013-01-01

    Full Text Available In den vergangenen Jahren wurden zahlreiche Moleküle aus unterschiedlichen Knochenstoffwechselwegen – so genannte „Knochenbiomarker“ – identifiziert. Sowohl Serum und Plasma als auch Harnanalysen werden für klinische Messungen des Knochenstoffwechsels herangezogen, wobei die Genauigkeit und Nutzerfreundlichkeit Blutproben deutlich bevorzugt. Die systemische Messbarkeit dieser Labormarker außerhalb des Knochens dient dabei als Basis für einen aktuellen „Schnappschuss“ des Knochenstoffwechsels. Die Bedeutung der Knochenbiomarker 2012 liegt in der zunehmend ganzheitlichen Betrachtung von Knochenerkrankungen, wobei einzelne morphologische Messungen wie die Dual-Energie- Röntgenabsorptiometrie (DXA nicht mehr als einzige Methode zur Knochenbeurteilung herangezogen werden. Eine internationale Standardisierung der wichtigsten Knochenmarker zur besseren Vergleichbarkeit ist bereits im Laufen. Eine vereinfachte technische Umsetzung soll in den nächsten Jahren auch weniger spezialisierte Labors und Point-of-Care-Tests einschließen, wobei neue Erkenntnisse aus der Präanalytik von Bedeutung sind. Ob sich Knochenbiomarker in Zukunft weiter durchsetzen werden, hängt allerdings nicht nur von wissenschaftlichen und medizintechnischen, sondern auch von ökonomischen und demographischen Umständen ab.

  9. HCUP National (Nationwide) Inpatient Sample (NIS) - Restricted Access File

    Data.gov (United States)

    U.S. Department of Health & Human Services — The NIS is the largest publicly available all-payer inpatient care database in the United States. It contains data from approximately 8 million hospital stays each...

  10. SMOKING HABITS OF NIS PRESCHOOL CHILDREN'S PARENTS

    Directory of Open Access Journals (Sweden)

    Miodrag Vucic

    2007-10-01

    Full Text Available The greatest threat for the public health in Serbia is definitively smoking. 1,3 billion of people in the world are smokers and 4,9 million of death at the global level are direct consequences of smoking. If this smoking rhythm continues until 2020. the number of deaths caused by smoking will have been doubled. There are 4000 identified substances in the tobacco smoke, 50 of which have been proven to be carcinogenic. Nowdays, 14000 to 15000 young people in the developed countries and 68000-84000 in the underdeveloped contries begin to smoke. 700 millions of children, the half of the whole children population, are exposed to the passive smoking.The prevalence of smoking in Serbia, although reduced by 6,9% compared to 2000 is still very high and makes 33,6% of the whole population (38,1% of men and 29,9% of women.The aim of this study was to investigate the smoking habits of preschool children's parents, motivated by the fact that the children of that age are highly sensitive and susceptible to the toxic influence of tobacco smoke, but also to check the necessity for an aggressive public health programme implementation in the aimed populations.This research, as a cross-sectional stady, is carried out among preschool children's parents, children being 4 to 6 years old that attend nursery schools in Nis.The prevalence of smoking in preschool children's parents is extremely high, and makes 46% (45,1% of men and 46,9% of women. Having taken into consideration the parental role in upbringing and education of children, as well as the influence of passive smoking, the main conclusion is that the children's health is seriously endangered. Education, making new and maintaining already existing programmes and legal obligations considering smoking are significant steps for reducing smoking and promoting health.

  11. Principles of classification of NIS reserves ampersand resources

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    The newly independent states of the former Soviet Union (NIS) control large resources of uranium. These resources have been the subject of substantial debate within several forums of the Western uranium industry because of confusion surrounding the degree of correlation between the Soviet and various Western classification systems. As illustrated in this article, although developed independently of Western systems, the classification system used by the NIS is very definitive and provides a sound basis for resource reporting. In 1981 a new open-quotes System of Classification of Reserves and Resources of Mineral Depositsclose quotes was adopted. This classification system, which is still used today in the newly independent states of the former Soviet Union (NIS), subdivides mineral deposits into seven categories in three major groups, based on the level of exploration performed: (1) Explored Reserves (A, B, C 1 ); (2) Evaluated Reserves (C 2 ); and (3) Predicted Resources (P 1 , P 2 , P 3 )

  12. The distribution of work performed on a NIS junction

    DEFF Research Database (Denmark)

    Santos, Jaime Eduardo Vieira da Silva Moutinho; Ribeiro, Pedro; Kirchner, Stefan

    2016-01-01

    We propose an experimental setup to measure the work performed in a normal-metal/insulator/superconducting (NIS) junction, subjected to a voltage change and in contact with a thermal bath. We compute the performed work and argue that the associated heat release can be measured experimentally. Our...... results are based on an equivalence between the dynamics of the NIS junction and that of an assembly of two-level systems subjected to a circularly polarised field, for which we can determine the work-characteristic function exactly. The average work dissipated by the NIS junction, as well as its...... fluctuations, are determined. From the work characteristic function, we also compute the work probability-distribution and show that it does not have a Gaussian character. Our results allow for a direct experimental test of the Crooks–Tasaki fluctuation relation....

  13. The distribution of work performed on a NIS junction

    International Nuclear Information System (INIS)

    Santos, Jaime E; Ribeiro, Pedro; Kirchner, Stefan

    2016-01-01

    We propose an experimental setup to measure the work performed in a normal-metal/insulator/superconducting (NIS) junction, subjected to a voltage change and in contact with a thermal bath. We compute the performed work and argue that the associated heat release can be measured experimentally. Our results are based on an equivalence between the dynamics of the NIS junction and that of an assembly of two-level systems subjected to a circularly polarised field, for which we can determine the work-characteristic function exactly. The average work dissipated by the NIS junction, as well as its fluctuations, are determined. From the work characteristic function, we also compute the work probability-distribution and show that it does not have a Gaussian character. Our results allow for a direct experimental test of the Crooks–Tasaki fluctuation relation. (paper)

  14. DEVELOPMENT OF A SCREENING APPROACH TO DETECT THYROID DISRUPTING CHEMICALS THAT INHIBIT THE HUMAN SODIUM IODIDE SYMPORTER (NIS)

    Data.gov (United States)

    U.S. Environmental Protection Agency — Data pertaining to a NIS-expressing cell line, hNIS-HEK293T-EPA, and its screening capabilities for determining inhibitors of NIS-mediated iodide uptake. This...

  15. The presence of modifiable residues in the core peptide part of precursor nisin is not crucial for precursor nisin interactions with NisB- and NisC.

    Directory of Open Access Journals (Sweden)

    Rustem Khusainov

    Full Text Available Precursor nisin is a model posttranslationally modified precursor lantibiotic that can be structurally divided into a leader peptide sequence and a modifiable core peptide part. The nisin core peptide clearly plays an important role in the precursor nisin-nisin modification enzymes interactions, since it has previously been shown that the construct containing only the nisin leader sequence is not sufficient to pull-down the nisin modification enzymes NisB and NisC. Serines and threonines in the core peptide part are the residues that NisB specifically dehydrates, and cysteines are the residues that NisC stereospecifically couples to the dehydrated amino acids. Here, we demonstrate that increasing the number of negatively charged residues in the core peptide part of precursor nisin, which are absent in wild-type nisin, does not abolish binding of precursor nisin to the modification enzymes NisB and NisC, but dramatically decreases the antimicrobial potency of these nisin mutants. An unnatural precursor nisin variant lacking all serines and threonines in the core peptide part and an unnatural precursor nisin variant lacking all cysteines in the core peptide part still bind the nisin modification enzymes NisB and NisC, suggesting that these residues are not essential for direct interactions with the nisin modification enzymes NisB and NisC. These results are important for lantibiotic engineering studies.

  16. Nursing Information System (NIS): A Tool for Qualitative Nursing ...

    African Journals Online (AJOL)

    Increasing health care cost, nurse shortages, high patient acuity and the need for more accuracy in care create the need for an effective Nursing Information System. This paper therefore highlights the relevance of NIS in enhancing professional growth and efficiency in nursing practice. It also opens up the anticipated ...

  17. Dėl žem. jeĩnis

    Directory of Open Access Journals (Sweden)

    Zigmas Zinkevičius

    2011-05-01

    Full Text Available CONCERNING SAMOGITIAN jeĩnis SummaryThe pronoun jeĩnis, -ė ʽhe, she’, noticed by V. Grinaveckis in a Samogitian dialect of Lithu­anian, is treated as an emphatic pronoun by the author of this paper. The pronoun originated on the basis of the epenthetic forms Acc. Sg. fem. jeĩnę and Instr. Sg. fem. jéine, used side by side with the regular dialect jeñję, jénje (= Standard Lith. Ją̃ją, ją́ja. The Nom. Sg. fem. jeĩnė (next to jeĩnę : jéine appeared according to the pattern kárvė : karvę : kárve; the Nom. Sg. masc. jeĩnis arose (next to jeĩnė according to the pattern medìnis : medìnė.

  18. Cloning of nis gene and Nisin purification from Lactococcus lactis ...

    African Journals Online (AJOL)

    The purified nisin by chloroform extraction was analyzed on 20% SDS-PAGE and gave sharp band at ~ 3.4 kDa. The 3 dimension structure of the purified Nisin was studied by CPHModels as pdb with chimera program. Keywords: Lactococcus lactis, nis cloning, 16S rRNA, chloroform extraction and SDS-PAGE

  19. Specificity and Application of the Lantibiotic Protease NisP

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    Manuel Montalbán-López

    2018-02-01

    Full Text Available Lantibiotics are ribosomally produced and posttranslationally modified peptides containing several lanthionine residues. They exhibit substantial antimicrobial activity against Gram-positive bacteria, including relevant pathogens. The production of the model lantibiotic nisin minimally requires the expression of the modification and export machinery. The last step during nisin maturation is the cleavage of the leader peptide. This liberates the active compound and is catalyzed by the cell wall-anchored protease NisP. Here, we report the production and purification of a soluble variant of NisP. This has enabled us to study its specificity and test its suitability for biotechnological applications. The ability of soluble NisP to cleave leaders from various substrates was tested with two sets of nisin variants. The first set was designed to investigate the influence of amino acid variations in the leader peptide or variations around the cleavage site. The second set was designed to study the influence of the lanthionine ring topology on the proteolytic efficiency. We show that the substrate promiscuity is higher than has previously been suggested. Our results demonstrate the importance of the arginine residue at the end of the leader peptide and the importance of lanthionine rings in the substrate for specific cleavage. Collectively, these data indicate that NisP is a suitable protease for the activation of diverse heterologously expressed lantibiotics, which is required to release active antimicrobial compounds.

  20. hNIS-IRES-eGFP Dual Reporter Gene Imaging

    Directory of Open Access Journals (Sweden)

    Jiantu Che

    2005-04-01

    Full Text Available The human and rodent sodium iodide symporters (NIS have recently been cloned and are being investigated as potential therapeutic and reporter genes. We have extended this effort by constructing an internal ribosomal entry site (IRES-linked human NIS (hNIS-enhanced green fluorescent protein (eGFP hybrid reporter gene for both nuclear and optical imaging. A self-inactivating retroviral vector, termed pQCNIG, containing hNIS-IRES-eGFP dual reporter gene, driven by a constitutive CMV promoter, was constructed and used to generate RG2-pQCNIG cells and RG2-pQCNIG tumors. 131I-iodide and 99mTcO4-pertechnetate accumulation studies plus fluorescence microscopy and intensity assays were performed in vitro, and gamma camera imaging studies in RG2-pQCNIG and RG2 tumor-bearing athymic rats were performed. RG2-pQCNIG cells expressed high levels of hNIS protein and showed high intensity of eGFP fluorescence compared with RG2 wild-type cells. RG2-pQCNIG cells accumulated Na131I and 99mTcO4– to a 50:1 and a 170:1 tissue/medium ratio at 10 min, compared with 0.8:1.2 tissue/medium ratio in wild-type RG2 cells. A significant correlation between radiotracer accumulation and eGFP fluorescence intensity was demonstrated. RG2-pQCNIG and RG2 tumors were readily differentiated by in vivo gamma camera imaging; radiotracer uptake increased in RG2-pQCNIG but declined in RG2 tumors over the 50-min imaging period. Stomach and thyroid were the major organs of radionuclide accumulation. The IRES-linked hNIS-eGFP dual reporter gene is functional and stable in transduced RG2-pQCNIG cells. Optical and nuclear imaging of tumors produced from these cell lines provides the opportunity to monitor tumor growth and response to therapy. These studies indicate the potential for a wider application of hNIS reporter imaging and translation into patient studies using radioisotopes that are currently available for human use for both SPECT and PET imaging.

  1. deNIS IIplus - computer-assisted crisis management system

    International Nuclear Information System (INIS)

    Corr, B.

    2007-01-01

    The management of catastrophes, as natural disasters or manmade disasters, will only be effective and successful if all relevant information is available in time for decision-makers. During previous large-scale disasters it became evident that information needed for the disaster management was only partially available and that there were fundamental deficits in regard to the flow of information between federal states (''Laender'') as well as communication problems between disaster response teams in the effected regions. On this account in summer 2001 the Federal Ministry of the Interior has decided to develop the ''German Emergency Preparedness Information System (deNIS)''. The aim of the enhanced version deNIS II plus is to built up a network for the civil and disaster response and to assist as an information and communication system for decision-makers of the Federal Government and the Laender Governments to better co-ordination relief and rescue teams in the event of a natural disaster or technical accident. Correspondingly the primary task of deNIS is to support the decision-making of disaster management authorities. (orig.)

  2. Preparation of a recombinant adenoviral encoding human NIS gene and its specific expression in cardiomyocytes

    International Nuclear Information System (INIS)

    Wang Lihua; Zhang Miao; Guo Rui; Shi Shuo; Li Biao

    2012-01-01

    Objective: To construct a recombinant adenovirus vector containing the human NIS gene with the myosin light chain-2(MLC-2v) gene as the promoter and evaluate its specific expression and feasibility as a reporter gene in cardiomyocytes. Methods: MLC-2v promoter and NIS were subcloned into an adenovirus shuttle vector, and forwarded by homologous recombination in the bacteria BJ5183 containing AdEasy-1 plasmid. Positive recombinant adenovirus vector was selected, packaged and amplified in the HEK293 cells to obtain recombinant adenovirus Ad-MLC-NIS. Ad-cytomegalovirus (CMV)-NIS with cytomegalovirus as the promoter, Ad-MLC without NIS and Ad-NIS without promoter were constructed as the controls. Cardiomyocytes and non-cardiomyocytes were then infected by the adenovirus. The protein expression was tested by Western blot analysis. The function and features of NIS protein were evaluated by dynamic iodide uptake and NaClO 4 iodine uptake inhibition test in vitro. The viability and proliferation of cardiomyocytes after adenovirus transfection and radioiodine incubation were checked by trypan blue staining. Results: Recombinant NIS adenovirus was successfully constructed. Western blot analysis showed that the NIS protein was highly expressed in cardiomyocytes transfected with Ad-MLC-NIS, and all cells transfected with Ad-CMV-NIS. However, in non-cardiomyocytes transfected with Ad-MLC-NIS, little NIS protein was detected. Dynamic iodine uptake tests showed that the peaks of iodide uptake of the three different cell lines (H9C2, A549, U87 cell) transfected with Ad-MLC-NIS were 5844.0, 833.6 and 846.0 counts · min -1 , respectively. The iodide uptake function of H9C2 was inhibited by NaClO 4 . There was almost no change in cell viability and proliferation when the MOI was 100. Conclusions: Ad-MLC-NIS allows myocardial specific expression of an external gene, and the cardiomyocytes with NIS expression are capable of iodine uptake. Further research of NIS as a reporter gene in

  3. Sodium iodide symporter (NIS) in extrathyroidal malignancies: focus on breast and urological cancer

    International Nuclear Information System (INIS)

    Micali, Salvatore; Bulotta, Stefania; Puppin, Cinzia; Territo, Angelo; Navarra, Michele; Bianchi, Giampaolo; Damante, Giuseppe; Filetti, Sebastiano; Russo, Diego

    2014-01-01

    Expression and function of sodium iodide symporter (NIS) is requisite for efficient iodide transport in thyrocytes, and its presence in cancer cells allows the use of radioiodine as a diagnostic and therapeutic tool in thyroid neoplasia. Discovery of NIS expression in extrathyroidal tissues, including transformed cells, has opened a novel field of research regarding NIS-expressing extrathyroidal neoplasia. Indeed, expression of NIS may be used as a biomarker for diagnostic, prognostic, and therapeutic purposes. Moreover, stimulation of endogenous NIS expression may permit the radioiodine treatment of extrathyroidal lesions by concentrating this radioisotope. This review describes recent findings in NIS research in extrathyroidal malignancies, focusing on breast and urological cancer, emphasizing the most relevant developments that may have clinical impact. Given the recent progress in the study of NIS regulation as molecular basis for new therapeutic approaches in extrathyroidal cancers, particular attention is given to studies regarding the relationship between NIS and clinical-pathological aspects of the tumors and the regulation of NIS expression in the experimental models

  4. IAEA co-ordinated technical support programme to the NIS

    International Nuclear Information System (INIS)

    Olsen, R.; Murakami, K.; Blacker, C.; Sharma, S.K.

    1999-01-01

    With most Newly Independent States (NIS) of the former Soviet Union becoming parties to the Non-Proliferation Treaty as Non-Nuclear Weapon States, there has been an acute need in these states for considerable assistance for the establishment of the necessary structure and resources to ensure that their commitments to non-proliferation are fully implemented in a timely manner. A number of IAEA Member States have offered and are now providing assistance to the NIS on a bilateral level to set up an appropriate State System of Accounting and Control (SSAC) which includes Import/Export Control and Physical Protection of Nuclear Material in each state. The IAEA and these Member States established the Co-ordinated Technical Support Programme (CTSP) to ensure that the support given to the NIS was done in a co-ordinated and transparent manner and to avoid duplication of effort. The IAEA has played a coordinating role for the past 5 years by helping to identify detailed needs in individual States, by providing a platform for Member States to identify areas where they could provide the optimum support, and in developing and preparing the Co-ordinated Technical Support Plans. The IAEA organises annual meetings in Vienna attended by all donor and recipient countries to review the focus and implementation status of the co-ordinated technical support activities. A position statement is made by each donor and recipient country, and views and experiences are exchanged. The contents of the CTSPs and the role of the Agency in monitoring the progress of the individual tasks are reviewed in this paper. A summary comparing the implementation status of the Programme by each country is presented. (author)

  5. Prognostische Bedeutung der physikalischen Streßechokardiographie bei 3329 ambulanten Patienten (5jährige Langzeitstudie)

    OpenAIRE

    Leischik R; Dworrak B; Gülker H; Littwitz H

    2005-01-01

    Hintergrund und Fragestellung: Die Risikoeinschätzung ambulanter Patienten mit thorakaler Schmerzsymptomatik ist ein wichtiges klinisches Problem. Über die prognostische Bedeutung der physikalischen Streßechokardiographie (SE) bei diesem Patientenkollektiv wurde bis jetzt nicht berichtet. Patienten und Methoden: Um die prognostische Bedeutung der physikalischen Streßechokardiographie bei rein ambulanten Patienten zu untersuchen, wurden 3329 Patienten bezüglich des Auftretens schwerer Erei...

  6. The sodium iodide symporter (NIS) and potential regulators in normal, benign and malignant human breast tissue.

    LENUS (Irish Health Repository)

    Ryan, James

    2011-01-01

    The presence, relevance and regulation of the Sodium Iodide Symporter (NIS) in human mammary tissue remains poorly understood. This study aimed to quantify relative expression of NIS and putative regulators in human breast tissue, with relationships observed further investigated in vitro.

  7. The iodide sym-porter (NIS): new perspectives in nuclear oncology

    International Nuclear Information System (INIS)

    Pourcher, Th.; Lindenthal, S.; Basquin, C.; Ferhat, O.; Marsault, R.; Carrier, P.; Koulibaly, M.; Bussiere, F.; Darcourt, J.

    2005-01-01

    The sodium iodide sym-porter (NIS) is the plasma membrane protein that mediates uptake of iodide in the thyroid and other organs such as the stomach and the salivary gland. The cloning of its cDNA allows the targeting of NIS expression into any cell using gene therapy. This enables iodide uptake and thus NIS can be used as reporter imaging for live animals. More intriguingly, this new technique has potential using radio-iodide therapy to selectively destroy tumour cells. These two approaches employ common techniques in nuclear medicine. Many experiments on cultured cells and on animals have been carried out; they established clearly the advantages of this genetically targeted radiotherapy. Recent studies employing this therapy on multiple myeloma cell lines implanted in mice or on hepato-carcinoma-bearing rats, resulted in important tumour remission. However, additional studies on NIS regulation and the use of alternative radioisotopes transported by NIS are required to further develop this promising approach. (author)

  8. O ténis e a moda

    OpenAIRE

    Morais-Alexandre, Paulo

    2010-01-01

    Interagindo com a evolução do vestuário, o desporto em geral e o ténis em particular têm influenciado ao longo dos tempos a Moda, sendo o contrário também verdadeiro. Assim, muitos dos trajes adaptados à prática desportiva vão passando para o traje quotidiano, da mesma forma que algumas das inovações da Moda são incorporadas no vestuário usado para praticar desporto, ao nível da forma, mas também das cores, padrões, ornamentos, etc., sendo ainda possível verificar neste âmbito a influência do...

  9. Identification of essential amino acid residues in the nisin dehydratase NisB

    Directory of Open Access Journals (Sweden)

    Rustem eKhusainov

    2015-02-01

    Full Text Available Nisin is a posttranslationally-modified antimicrobial peptide that has the ability to induce its own biosynthesis. Serines and threonines in the modifiable core peptide part of precursor nisin are dehydrated to dehydroalanines and dehydrobutyrines by the dehydratase NisB, and subsequently cysteines are coupled to the dehydroamino acids by the cyclase NisC. In this study, we applied extensive site-directed mutagenesis, together with direct binding studies, to investigate the molecular mechanism of the dehydratase NisB. We use a natural nisin-producing strain as a host to probe mutant-NisB functionality. Importantly, we are able to differentiate between intracellular and secreted fully dehydrated precursor nisin, enabling investigation of the NisB properties needed for the release of dehydrated precursor nisin to its devoted secretion system NisT. We report that single amino acid substitutions of conserved residues, i.e. R83A, R83M and R87A result in incomplete dehydration of precursor nisin and prevention of secretion. Single point NisB mutants Y80F and H961A, result in a complete lack of dehydration of precursor nisin, but do not abrogate precursor nisin binding. The data indicate that residues Y80 and H961 are directly involved in catalysis, fitting well with their position in the recently published 3D-structure of NisB. We confirm, by in vivo studies, results that were previously obtained from in vitro experiments and NisB structure elucidation and show that previous findings translate well to effects seen in the original production host.

  10. The construction and identification of hypoxia-regulated recombinant plasmid with reporter gene hNIS

    International Nuclear Information System (INIS)

    Hu Qunchao; Wu Jinchang; Zhou Jundong; Gu Ke

    2011-01-01

    Objective: To construct pShuttle-5 × HRE-CMV-NIS recombinant plasmid regulated by hypoxia-responsive element, which can possibly by used to detect the expression of hypoxia induced factor-α (HIF-1α) gene under hypoxia condition. Methods: Artificially synthesize the nucleotide sequences of five copies of hypoxia response elements (HREs) were cloned into pGL3-promoter vector to construct pGL3-promoter-5 × HRE vector. Human sodium/iodide symporter (hNIS) gene cDNA was amplified from human genome by RT-PCR, and subcloned into pGL3-promoter-5 × HRE vector then was sequenced. After treated with CoCl 2 as hypoxia mimic, HEK293 cells were transfected with recombinant plasmid with hNIS gene, while cells treated with DMSO as the control. Meanwhile, pcDNA3.1-HIF-1α and recombinant hNIS gene vectors were transfected into HEK293 cells at the ratio of 3 to 1, while co-transfection with pcDNA3.1 and pShuttle-NIS vectors cells were taken as the control. NIS mRNA expression was analyzed by qRT-PCR while function of NIS protein was tested by 99m TcO 4 - -uptake. Results: The sequence data of hNIS gene in recombinant plasmid were in accordance with those reported in the literatures. Compared with control groups, HEK293 cells co-transfected with both pShuttle-5 × HRE-CMV-NIS and HIF-1α gene vectors and CoCl 2 -treated after pShuttle-NIS transfecting presented higher mRNA expressions of NIS and 99m TcO 4 - uptake (P<0.01). Conclusion: HIF-1α can be bound to and activate pShuttle-5 × HRE-CMV-NIS in cells to accumulate radioactive nuclide 99m TcO 4 - and this technique is potential for detection of expression and activity of HIF-1α, the indicator of cell hypoxia. (authors)

  11. Comparison of human sodium iodide symporter (hNIS) gene expression between lentiviral and adenoviral vectors in rat mesenchymal stem cell

    International Nuclear Information System (INIS)

    Park, So Yeon; Lee, Won Woo; Kim, Sung Jin; Lee, Heui Ran; Kim, Hyun Joo; Chung, June Key; Kim, Sang Eun

    2007-01-01

    Quantitative comparison of transgene expression within stem cells between lentivirus and adenovirus-mediated delivery systems has not been done. Here, we evaluated the human sodium iodide symporter (hNIS) gene expression in rat mesenchymal stem cell (rMSC) transduced by lentivirus or adenovirus, and compared the hNIS expression quantitatively between the two delivery systems. Lentiviral-mediated stably hNIS expressing rMSC (lenti-hNIS-rMSC) was constructed by cloning the hNIS gene into pLenti6/UbC/V5-DEST (Invitrogen) to obtain pLenti-hNIS, transducing rMSC with the pLenti-hNIS, and selecting with blasticidin for 3 weeks. Recombinant adenovirus expressing hNIS gene (Rad-hNIS) was produced by homologous recombination and Rad-hNIS transduced rMSC (adeno-hNIS-rMSC) was evaluated for the hNIS expression 48 hours post infection at MOI 1, 5, 20, 50, and 100. The hNIS expression in lenti-hNIS-rMSC or adeno-hNIS-rMSC was assessed by immunocytochemistry, western blot, and I-125 uptake. Immunocytochemistry using mono-clonal anti-hNIS antibody revealed that intensity of hNIS immunoreactivity in lenti-hNIS-rMSC was greater than that in adeno-hNIS-rMSC at MOl 20 but lower than that at MOl 50. Western blot analysis also showed that lenti-hNIS-rMSC was intermediate between adeno-hNIS-rMSCs at MOl 20 and 50 in hNIS expression. However in vitro I-125 uptake test demonstrated that iodide uptake in lenti-hNIS-rMSC (297046659 picomole/106 cells) was greater than that in adeno-hNIS-rMSC at MOI 100 (61682134 picomole/106 cells). These results suggest that lentivirus mediated hNIS expression is greater in terms of hNIS function but lower in terms of hNIS protein amount than adenovirus mediated hNIS expression 48 hours post infection. Stem cell tracking using hNIS as a reporter gene should be conducted in consideration of relative viral efficiency of transgene expression

  12. Zur Beteiligung und Bedeutung von Großeltern in strittigen Sorgerechtsverfahren

    OpenAIRE

    Speidel, Leonie

    2009-01-01

    Die Beteiligung und Bedeutung von Großeltern in strittigen Sorgerechtsverfahren wurde anhand von 28 kinder- und jugendpsychiatrischen Gutachten über 36 Kinder analysiert. Die Beteiligung der Großeltern an familiären Interaktionen sowie ihre vielfältigen Rollen und Funktionen in der Familie nehmen nach der Trennung zu. Ihre Bedeutsamkeit steigt vor allem für ihre Enkel an. Vor der Separation unterstützen die Großeltern die Eltern in finanziellen Bereichen, im Haushalt und stundenweise i...

  13. SANITARY ASPECT OF NUTRITION CONTROL IN PUBLIC KITCHEN IN NIS

    Directory of Open Access Journals (Sweden)

    Suzana Milutinovic

    2006-07-01

    Full Text Available The aim of the paper was to evaluate sanitary condition of food preparation and distribution in the "Public kitchen" in Nis, as well as the meals’ quality in order to assess the health risks. The local inspection of the objects and microbiological analysis of swaps were done according to standard methods. Energetical values and biochemical structure of the meals were assessed by bromatological methods and energetical density was calculated. The study was being conducted from 2002 – 2005. The results show that sanitary conditions in the object were not adequate, because of a high percentage of incorrect samples (13.4% from the total number of samples. Energetical values of meals were usually adequate (1157 – 1564 kcal, 4837 – 6581 kJ, but constantly decreased. The chemical structure of the meals was adequate too, meaning that meals were very well- planed. The energetic density of meals was high (1,18 – 1,42 kcal/g. Our conclusion is that there are no alternatives to continuous health care education of the medical stuff and regular sanitary hygienic control, all with the aim to accomplish complete social function of the public kitchen and to protect the health of its consumers.

  14. Magnetic field measurement in the analyzing magnet of NIS spectrometer

    Science.gov (United States)

    Avramenko, S. A.; Afanas'ev, S. V.; Voloshina, I. G.; Dolgii, S. A.; Yusupov, A. Yu.; Kalmykov, A. V.; Makoveev, V. K.; Nikolaevskii, G. P.; Ostrovskii, I. V.; Perepelkin, E. E.; Peresedov, V. F.; Plyashkevich, S. N.; Rossiiskaya, N. S.; Salmin, R. A.; Spodarets, V. K.; Strokovskii, E. A.; Yudin, I. P.

    2006-12-01

    The main goals of the Nucleon Intrinsic Strangeness experiment (NIS) are the search for the effects of hidden polarized strangeness in the nucleon and the exploration and study of exotic baryons (pentaquarks) in NN reactions. The setup is located in the Laboratory of High Energies at the Joint Institute for Nuclear Research in channel 4V of the Nuclotron extracted beam with the energy between 1 and 4 GeV. The 1SP-40-4V electromagnet of the spectrometer has the external dimensions 3.20 × 3.26 × 4.48 m and the aperture 2.74 × 0.68 m. The magnetic field measurement was performed using the three-component Hall magnetometer in the computer-controlled automated mode. The volume of measurements was 1.03 × 0.60 × 3.92 m. The description of the measuring equipment and measurement procedure is given. The results of the measurements are used for the Monte Carlo computer modeling of the experiment. These results will be used in the analysis of physical data after their acquisition.

  15. The potential of 211Astatine for NIS-mediated radionuclide therapy in prostate cancer

    International Nuclear Information System (INIS)

    Willhauck, Michael J.; Sharif Samani, Bibi-Rana; Goeke, Burkhard; Wolf, Ingo; Senekowitsch-Schmidtke, Reingard; Stark, Hans-Juergen; Meyer, Geerd J.; Knapp, Wolfram H.; Morris, John C.; Spitzweg, Christine

    2008-01-01

    We reported recently the induction of selective iodide uptake in prostate cancer cells (LNCaP) by prostate-specific antigen (PSA) promoter-directed sodium iodide symporter (NIS) expression that allowed a significant therapeutic effect of 131 I. In the current study, we studied the potential of the high-energy alpha-emitter 211 At, also transported by NIS, as an alternative radionuclide after NIS gene transfer in tumors with limited therapeutic efficacy of 131 I due to rapid iodide efflux. We investigated uptake and therapeutic efficacy of 211 At in LNCaP cells stably expressing NIS under the control of the PSA promoter (NP-1) in vitro and in vivo. NP-1 cells concentrated 211 At in a perchlorate-sensitive manner, which allowed a dramatic therapeutic effect in vitro. After intrapertoneal injection of 211 At (1 MBq), NP-1 tumors accumulated approximately 16% ID/g 211 At (effective half-life 4.6 h), which resulted in a tumor-absorbed dose of 1,580 ± 345 mGy/MBq and a significant tumor volume reduction of up to 82 ± 19%, while control tumors continued their growth exponentially. A significant therapeutic effect of 211 At has been demonstrated in prostate cancer after PSA promoter-directed NIS gene transfer in vitro and in vivo suggesting a potential role for 211 At as an attractive alternative radioisotope for NIS-targeted radionuclide therapy, in particular in smaller tumors with limited radionuclide retention time. (orig.)

  16. Recovery of NIS expression in thyroid cancer cells by overexpression of Pax8 gene

    International Nuclear Information System (INIS)

    Presta, Ivan; Filetti, Sebastiano; Russo, Diego; Arturi, Franco; Ferretti, Elisabetta; Mattei, Tiziana; Scarpelli, Daniela; Tosi, Emanuele; Scipioni, Angela; Celano, Marilena; Gulino, Alberto

    2005-01-01

    Recovery of iodide uptake in thyroid cancer cells by means of obtaining the functional expression of the sodium/iodide symporter (NIS) represents an innovative strategy for the treatment of poorly differentiated thyroid cancer. However, the NIS gene expression alone is not always sufficient to restore radioiodine concentration ability in these tumour cells. In this study, the anaplastic thyroid carcinoma ARO cells were stably transfected with a Pax8 gene expression vector. A quantitative RT-PCR was performed to assess the thyroid specific gene expression in selected clones. The presence of NIS protein was detected by Western blot and localized by immunofluorescence. A iodide uptake assay was also performed to verify the functional effect of NIS induction and differentiation switch. The clones overexpressing Pax8 showed the re-activation of several thyroid specific genes including NIS, Pendrin, Thyroglobulin, TPO and TTF1. In ARO-Pax8 clones NIS protein was also localized both in cell cytoplasm and membrane. Thus, the ability to uptake the radioiodine was partially restored, associated to a high rate of efflux. In addition, ARO cells expressing Pax8 presented a lower rate of cell growth. These finding demonstrate that induction of Pax8 expression may determine a re-differentiation of thyroid cancer cells, including a partial recovery of iodide uptake, fundamental requisite for a radioiodine-based therapeutic approach for thyroid tumours

  17. Human sodium iodide symporter (hNIS) in fibroadenoma breast--a immunohistochemical study.

    Science.gov (United States)

    Rai, Ruchi; Shrivastava, Ashutosh; Tandon, Ashwani; Godbole, Madan M; Kumar, Sandeep; Das, Vinita; Dwivedi, Varsha; Pal, Lily

    2011-02-01

    Human sodium iodide symporter (hNIS), responsible for the active transport of iodine is an integral plasma membrane glycoprotein present in the thyroid cells and extrathyroid tissues like breast and salivary glands. If its functional form is unequivocally shown in benign or malignant breast tissues, then it may serve as a basis for diagnosis and treatment using radioactive iodine. With an aim to analyze the hNIS expression in a distinct benign breast condition of fibroadenoma, biopsy proven fibroadenoma tissues, normal non-lactating breast tissue and biopsy proven infiltrating duct carcinoma tissues were examined for hNIS expression using immunohistochemistry. Out of 20 biopsy proven fibroadenoma tissues, 19 (95%) showed positivity for hNIS protein and only one was negative. Of these 10% were mildly positive, 50% cases were moderately positive and 35% showed intense positivity. None of the control tissue obtained from reduction mammoplasty specimens or normal breast tissues samples (5 cms away from the tumor) were positive, hNIS was also intensely positive in 9 out of 10 (90%) infiltrating duct carcinoma tissues and moderately positive in one case. These preliminary results show that hNIS was present in high frequency as demonstrated by immunohistochemistry in fibroadenoma breast.

  18. The effect of 17-AAG on iodine uptake kinetics of NIS-transfected anaplastic thyroid cancer

    International Nuclear Information System (INIS)

    Wang Renfei; Tan Jian; Li Wei; Meng Zhaowei; Zheng Wei

    2012-01-01

    Objective: To investigate the effect of 17-allylamino-17-demethoxy geldanamycin (17-AAG) on iodine uptake kinetics of NIS-transfected anaplastic thyroid cancer (ATC) cells. Methods: Lipofection was used to transfect the recombinant plasmid, namely pcDNA3.1-NIS, into FRO cells (ATC cell line). A stable cell line NIS-FRO was obtained by G418 resistance selection. 125 I was added into the medium, and influx and efflux experiments were performed. Different time-radioactivity curves were drawn, and further analysis was performed between the non-transfected cells (the control group) and NIS-FRO cells treated with 1 μmol/L 17-AAG for 24 h. Student's t-test was used to analyze the data. Results: The iodine uptake ability of the NIS-FRO cells was significantly higher than that of the FRO cells (about 10.68 times, t=45.329, P<0.001). However, 125 I out-flowed rapidly when removed from the medium, and the retention rate of 125 I in the NIS-FRO cells was only 10.5% of the initial amount after 30 rin. After treatment with 1 μmol/L 17-AAG for 24 h, the 125 I uptake ability of NIS-FRO cells further increased. During the 20-60 min incubation with 125 I, the iodine uptake ability of 17-AAG treated NIS-FRO cells increased significantly with radioactive counts of 31771.8- 54815.5 per minute,which was much higher than that of the control group (24020.3-41293.8 per minute; t=3.096, 4.275, 3.055, 4.292 and 5.496, respectively, all P<0.05). The iodine uptake ability increased about 24.8%-35.5%. Furthermore, 5-30 min after removing the medium, the retention rates of 125 I in the 17-AAG treated NIS-FRO cells were significantly increased compared with those of the control group (32.7%-85.2% vs 10.5%-56.8%; t=22.801, 13.096, 19.631, 38.205, 43.519, 29.322, respectively, all P<0.01), and 125 I efflux was reduced. After 30 min, 125 I retention rate of the treatment group was 32.7%, which was 3.1 times higher than that of the control group. Conclusion: The iodine uptake ability can be

  19. Nuclear legislation in central and eastern europe and the NIS

    International Nuclear Information System (INIS)

    2003-01-01

    This study presents the current state of legislation and regulations governing the peaceful uses of nuclear energy in the central and eastern European countries (CEEC) and the New Independent States (NIS). It also contains information on the national bodies responsible for the regulation and control of nuclear energy. The nuclear energy sector has not escaped from the changes that have affected the political, economic and social climates over the past fifteen years. Under the former socialist regime, activities in this field came within the sole remit of the State administration. In the legal area, it had not been deemed necessary in most of these countries to enact laws guaranteeing democratic control of electronuclear programmes and establishing a clear distinction between activities promoting this source of energy and regulatory control, while ensuring that safety imperatives take priority over all other considerations. With the arrival of new political forces came the will to remedy this situation promptly by creating new regulatory structures and drafting legislative texts based on those used in western countries. This evolution was all the more necessary given that, at the same time, the new policy of accountability had revealed safety defects in numerous nuclear installations in these countries, thus rendering international assistance indispensable. From the legal point of view, the outcome of these years of effort is remarkably positive: almost all countries of Eastern Europe pursuing electronuclear programmes have established institutions capable of exercising efficient control over nuclear power plants and other installations. Accession to the international conventions which form the backbone of nuclear law has become widespread. Modern legislation is henceforth in place in almost all of these states. (author)

  20. Microwave-assisted synthesis of NiS2 nanostructures for supercapacitors and cocatalytic enhancing photocatalytic H2 production

    Science.gov (United States)

    Pang, Huan; Wei, Chengzhen; Li, Xuexue; Li, Guochang; Ma, Yahui; Li, Sujuan; Chen, Jing; Zhang, Jiangshan

    2014-01-01

    Uniform NiS2 nanocubes are successfully synthesized with a microwave-assisted method. Interestingly, NiS2 nanocubes, nanospheres and nanoparticles are obtained by controlling microwave reaction time. NiS2 nanomaterials are primarily applied to supercapacitors and cocatalytic enhancing photocatalytic H2 production. Different morphologies of NiS2 nanostructures show different electrochemical and cocatalytic enhancing H2 production activities. Benefited novel nanostructures, NiS2 nanocube electrodes show a large specific capacitance (695 F g-1 at 1.25 A g-1) and excellent cycling performance (the retention 93.4% of initial specific capacitance after 3000 cycles). More importantly, NiS2 nanospheres show highly cocatalytic enhancing photocatalytic for H2 evolution, in which the photocatalytic H2 production is up to 3400 μmol during 12 hours under irradiation of visible light (λ>420 nm) with an average H2 production rate of 283 μmol h-1.

  1. [Baltisches Welterlebnis. Die kulturgeschichtliche Bedeutung von Alexander, Eduard und Hermann Graf Keyserling. Beiträge eines internationalen Symposium in Tartu vom 19. bis 21. September 2003

    Index Scriptorium Estoniae

    Garleff, Michael, 1940-

    2011-01-01

    Baltisches Welterlebnis. Die kulturgeschichtliche Bedeutung von Alexander, Eduard und Hermann Graf Keyserling. Beiträge eines internationalen Symposium in Tartu vom 19. bis 21. September 2003. Heidelberg : Universitätsverlag Winter, 2007

  2. An extremely high dietary iodide supply forestalls severe hypothyroidism in Na+/I- symporter (NIS) knockout mice.

    Science.gov (United States)

    Ferrandino, Giuseppe; Kaspari, Rachel R; Reyna-Neyra, Andrea; Boutagy, Nabil E; Sinusas, Albert J; Carrasco, Nancy

    2017-07-13

    The sodium/iodide symporter (NIS) mediates active iodide (I - ) accumulation in the thyroid, the first step in thyroid hormone (TH) biosynthesis. Mutations in the SLC5A5 gene encoding NIS that result in a non-functional protein lead to congenital hypothyroidism due to I - transport defect (ITD). ITD is a rare autosomal disorder that, if not treated promptly in infancy, can cause mental retardation, as the TH decrease results in improper development of the nervous system. However, in some patients, hypothyroidism has been ameliorated by unusually large amounts of dietary I - . Here we report the first NIS knockout (KO) mouse model, obtained by targeting exons 6 and 7 of the Slc5a5 gene. In NIS KO mice, in the thyroid, stomach, and salivary gland, NIS is absent, and hence there is no active accumulation of the NIS substrate pertechnetate ( 99m TcO 4 - ). NIS KO mice showed undetectable serum T 4 and very low serum T 3 levels when fed a diet supplying the minimum I - requirement for rodents. These hypothyroid mice displayed oxidative stress in the thyroid, but not in the brown adipose tissue or liver. Feeding the mice a high-I - diet partially rescued TH biosynthesis, demonstrating that, at high I - concentrations, I - enters the thyroid through routes other than NIS.

  3. Study of rNIS as a reporter gene monitoring rBMSC transplanted to rat myocardium

    International Nuclear Information System (INIS)

    Hu Shou; Lan Xiaoli; Cao Wei; Cao Guoxiang; Zhang Guopeng; Zhang Binqing; Wu Tao; Chang Wei; Zhang Yongxue

    2010-01-01

    Objective: To investigate the feasibility of rat sodium/iodide symporter (rNIS) as a reporter gene monitoring rat bone marrow mesenchymal cells (rBMSC) transplanted to rat myocardium in vivo. Methods: Recombinated adenovirus vector was constructed by rNIS/enhanced green fluorescence protein (EGFP) (Ad-rNIS/EGFP). rBMSC transfected by Ad-rNIS/EGFP were studied using fluorescence microscope. Fifteen rats were transplanted with rBMSC and randomly divided into three groups: rNIS group (with rNIS transfection), blocked group (with rNIS transfection) by oral intake of perchloric sodium before planar imaging (GE Millennium MPR SPECT), and control group (without rNIS transfection). All rats underwent 99 Tc m -pertechnetate planar imaging. The biological distribution of 99 Tc m -pertechnetate was studied. The expressions of rNIS gene and protein in myocardium were measured by real time polymerase chain reaction (PCR) and western blot, respectively. The expressions of CD 29 , CD 44 , CD 90 , CD 11 b, CD 34 and CD 45 were measured by immunohistochemistry. Results: rBMSC transfected by Ad-rNIS/EGFP showed EGFP expression under fluorescence microscope. The transplanted rat myocardium could be visualized on 99 Tc m -pertechnetate planar imaging in rNIS group. The relative uptake ratio (R heart /R hmb , RUR) was 6.7 ±0.4. RUR in control group (3.0 ±0.2) was lower than that in rNIS group (t =2.78, P=0.03). The percentage injection dose per gram of tissue (% ID/g) of the transplanted myocardium was 60.2 ± 20.8 in rNIS group, which was higher than that (2.5 ± 0.4) % ID/g of control group ( t = 7.13, P 29 , CD 44 and CD 90 were positive, CD 45 and CD 45 negative CD 11 b mildly positive in the myocardium transplanted with infective rBMSC. Conclusion: rNIS can efficiently monitor rBMSC transplanted to rat myocardium. (authors)

  4. Identification of essential amino acid residues in the nisin dehydratase NisB

    NARCIS (Netherlands)

    Khusainov, Rustem; van Heel, Auke J.; Lubelski, Jacek; Moll, Gert N.; Kuipers, Oscar P.

    2015-01-01

    Nisin is a posttranslationally-modified antimicrobial peptide that has the ability to induce its own biosynthesis. Serines and threonines in the modifiable core peptide part of precursor nisin are dehydrated to dehydroalanines and dehydrobutyrines by the dehydratase NisB, and subsequently cysteines

  5. Use of the Lactococcal nisA Promoter To Regulate Gene Expression in Gram-Positive Bacteria : Comparison of Induction Level and Promoter Strength

    NARCIS (Netherlands)

    Eichenbaum, Zehava; Federle, Michael J.; Marra, Diana; Vos, Willem M. de; Kuipers, Oscar P.; Kleerebezem, Michiel; Scott, June R.

    1998-01-01

    We characterized the regulated activity of the lactococcal nisA promoter in strains of the gram-positive species Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus pneumoniae, Enterococcus faecalis, and Bacillus subtilis. nisA promoter activity was dependent on the proteins NisR and

  6. 99Tcm pertechnetate uptake by hepatoma cells induced by tissue specific hNIS gene expression

    International Nuclear Information System (INIS)

    Chen Libo; Luo Quanyong; Yu Yongli; Yuan Zhibin; Lu Hankui; Zhu Ruisen; Guo Lihe

    2007-01-01

    Objective: Human sodium/iodide symporter (hNIS) gene could be used both as an ideal reporter gene and promising therapeutic gene. Rather than radioiodine, 99 Tc m pertechnetate has been proven to be a better radiopharmaceutical for tracing and imaging purposes. Herein, the authors investigated the feasibility of monitoring hNIS gene expression in hepatoma cells using 99 Tc m pertechnetate as a tracer. Methods: Hepatoma cells MH3924A were stably transfected with recombinant retroviral vector in which hNIS cDNA was driven by murine albumin enhancer/promoter (mAlb) and coupled to hygromycin resistance gene. The uptake and efflux of 99 Tc m pertechnetate by transfected hepatoma cells were tested with 99 Tc m pertechnetate (74 kBq) solution adulterated into the culture media and counted after media suspension discharge at different intervals. In further tests, 50 μmol/L NaClO 4 and 500 μmol/L Ouabain were added into the media for 99 Tc m inhibition tests. For in vive studies, five ACI rats bearing NIS transfected hepatoma xenografts were injected with 99 Tc m pertechnetate (15.8 MBq) and followed by dynamic acquisition (0.57 1, 2 and 4 h) with small gamma camera to semi-quantitatively analyze the radioactivity distribution. Results: In vitro tests, the peak uptake of 99 Tc m pertechnetate by cultured transfected MH3924A cells was up to 254 folds higher than that by the wild type cells. 99 Tc m uptake by transfected cells were significantly inhibited by NaClO 4 down to 2.44% (P 99 Tc m pertechnetate out of cultured transfected cells became rapid immediately after renewal of culture media (half life 99 Tc m accumulations by hNIS transfected tumor xenografts were obvious in early phases of the acquisition with peak uptake at 12 min and gradually declining later on. Conclusions: hNIS transfected hepatoma cells can avidly uptake 99 Tc m pertechnetate both in vitro and in vive. It is feasible to utilize 99 Tc m pertechnetate for monitoring and even quantitatively analyzing

  7. Towards a biochemical and structural characterisation of the sodium-iodide sym-porter (Nis)

    International Nuclear Information System (INIS)

    Darrouzet, E.; Marcellin, D.; Huc, S.; Quemeneur, E.; Pourcher, T.

    2006-01-01

    Iodide is essential for thyroid hormone biosynthesis in mammals, and therefore for the control of cell metabolism and the development of the central nervous system in the foetus and newborns, but is relatively scarce element in the environment. To ensure its accumulation, the thyroid gland has evolved a remarkably efficient system, the sodium-iodide sym-porter (NIS), that was first characterized at the molecular level 10 years ago (1). NIS is an intrinsic protein mainly located in the basolateral membrane of thyroid follicular cells where it actively transports iodide ions using the sodium gradient as a driving force (2,3). In addition, this transporter has been found in lactating mammary gland, stomach, and salivary glands, and its mRNA was detected in brain, ovaries, testis. To date, the physiological role of NIS in these organs is not yet identified (3,4).The capacity of NIS to mediate the accumulation of radioactive iodide has been exploited for many years in the diagnosis of thyroid cancer as well as for the detection and radiotherapy of derived metastases. Moreover, the presence of NIS in some breast tumours and the possibility to express it by targeted gene therapy in tumour cells where it is not naturally present could also widen its medical application (4-7). In case of accidental contamination, NIS would also be responsible for accumulation of radioisotopes in the thyroid and for their transfer to the milk and the newborn, eventually causing thyroid cancers. This has motivated our research program in the perspective of designing novel specific therapeutics. During the last decade, the gene encoding the thyroid NIS has been identified and sequenced in various species including rat, mouse and human (1, 8). It was also demonstrated that the protein expression and activity are highly regulated both at the transcriptional and post-translational levels (3). A preliminary topological mode could be drawn from the protein sequence. It proposes a general

  8. Au-controlled enhancement of photoluminescence of NiS nanostructures synthesized via a microwave-assisted hydrothermal technique

    International Nuclear Information System (INIS)

    Linganiso, Ella Cebisa; Mwakikunga, Bonex Wakufwa; Mhlanga, Sabelo Dalton; Coville, Neil John

    2014-01-01

    Nickel sulphide (NiS) nanostructures decorated with gold (Au) nanoparticles (NPs) were synthesized via a microwave-assisted hydrothermal technique. Binary phase NiS (α and β) crystalline nanostructures, bare, and decorated with Au NPs were obtained and confirmed by X-ray diffraction (XRD) studies. TEM analysis revealed that the NiS nanostructures were of various shapes. A quantum confinement effect was confirmed by the blue shift PL emissions and high optical energy band gap observed for the as-synthesized sample. A threefold light emission enhancement due to Au NP coatings was obtained when Au metal NP decoration concentrations was varied from 1% to 10%. These enhancements were attributed to the surface plasmon resonance (SPR) excitation of the surface decorated metal NPs which results in an increased rate of spontaneous emission. The PL enhancement factor was observed to vary at different NiS emissions as well as with the size of the Au NPs. The effect of metal NP decoration on the PL emission of NiS is to the best of our knowledge, presented for the first time. - Highlights: • Binary phase NiS decorated with gold nanoparticles. • Quantum confinement effect confirmed by PL analysis. • PL enhancement depending more on particle size distribution. • Effect of gold on NiS PL is to the best of our knowledge reported for the first time

  9. The Main Directions of the Structural Defragmentation of the State Development Strategy of the NIS of Ukraine

    Directory of Open Access Journals (Sweden)

    Melnyk Alexander G.

    2018-03-01

    Full Text Available The article considers the scientific-methodical approach to bridging of gaps on the main directions, in systems of mechanisms and instruments of the State strategy for development of the National Innovation Strategy (NIS, caused by breaks in the system of interactions by elements of its organizational, technological, and institutional structure. This situation in the innovation system is defined as fragmentation of the basic structures of the NIS, which is interrelated by fragmentation of multi-level development strategies for development of the NIS. The most fragmented directions of the State strategy for development of the NIS of Ukraine are defined, among which the system of transfer of technologies and absence of corresponding strategic priorities, technological modernization of industry, integration of the research sphere into the world innovation space, creation of the high-tech sector of NIS. The main directions of structural defragmentation of the State Strategy for Development of the NIS are proposed: organization of innovation process, formation of development institutions, clustering of scientific and production sectors of the NIS, formation of environment to achieve technological leadership.

  10. "Tabula Sinvs Venetici" von W. Barents und ihre Geschichtilische und Geographische Bedeutung

    Directory of Open Access Journals (Sweden)

    Mithad Kozličić

    1999-06-01

    Full Text Available In der wissenschaftlichen Literatur sind zwei Varianten der Seekarte der Adria vom niederländischen Seefahrer und Polarforscher Willem Barents (1550-1597 bekannt. Die erste, in diesem Aufsatz als K-1 bezeichnete Karte, wurde in Amsterdam 1595 hergestellt und gedruckt. Sie hatte anfänglich eine praktisch-navigatorische Funktion. Die zweite, K-2, ins Jahr 1595 datierte (1637-1662 Karte, wurde als geostrategische Karte der Adria und der südlichen Teile Europas ausgenützt. An den adriatischen Nordküsten, besonders in ihrem Hinterland, geschahen mit dem Durchbruch der Türken seit der Hälfte des 16. Jahrhunderts wichtige militärische und politische Änderungen. In den “Atlanten” des Niederländers Jan (Johann; Joannes Janssonius (1588-1664 fehlte gerade solch eine Karte, die auch mehrmals in Amsterdam gedruckt wurde, aber zwischen 1637 und 1662. Die K-1 von Barents, deren Druckplatte Janssonius zur Verfügung hatte, konnte diese Funktion befriedigen. Deswegen machte Janssonius nur die nötigen dem darstellenden Standard der ersten Hälfte des 17. Jahrhunderts entsprechenden Änderungen, und als solche wurde sie gedruckt. Die K-2 verlor ihre ursprüngliche praktisch-navigatorische Funktion und wurde eine Karte von geostrategischer Bedeutung. Mit diesen Grundfragen befaßt sich dieser Aufsatz.

  11. Comparison of Human Sodium/Iodide Symporter (hNIS) Gene Expressions between Lentiviral and Adenoviral Vectors in Rat Mesenchymal Stem Cells

    Energy Technology Data Exchange (ETDEWEB)

    Park, So Yeon; Lee, Won Woo; Kim, Hyun Joo; Chung, June Key; Kim, Sang Eun [Seoul National University College of Medicine, Seoul (Korea, Republic of); Kim, Sung Jin; Lee, Heui Ran [Medical Research Center, Seoul National University, Seoul (Korea, Republic of)

    2008-10-15

    Quantitative comparison of transgene expression within stem cells between lentivirus and adenovirusmediated delivery systems has not been reported. Here, we evaluated the human sodium iodide symporter (hNIS) gene expression in rat mesenchymal stem cell (rMSC) transduced by lentivirus or adenovirus, and compared the hNIS expression quantitatively between the two delivery systems. Lentiviral-mediated hNIS expressing rMSC (lenti-hNIS-rMSC) was constructed by cloning hNIS gene into pLenti6/UbC/V5-DEST (Invitrogen) to obtain pLenti-hNIS, transducing rMSC with the pLenti-hNIS, and selecting with blasticidin for 3 weeks. Recombinant adenovirus expressing hNIS gene (Rad-hNIS) was produced by homologous recombination and transduction efficiency of Rad-hNIS into rMSC evaluated by Rad-GFP was 19.1{+-}4.7%, 54.0{+-}6.4%, 85.7{+-}8.7%, and 98.4{+-}1.3% at MOI 1, 5, 20, and 100, respectively. The hNIS expressions in lenti-hNIS-rMSC or adeno-hNIS-rMSC were assessed by immunocytochemistry, western blot, and I-125 uptake. Immunocytochemistry and western blot analyses revealed that hNIS expressions in lenti-hNIS-rMSC were greater than those in adeno-hNIS-rMSC at MOI 20 but lower than at MOI 50. However in vitro I-125 uptake test demonstrated that iodide uptake in lenti-hNIS-rMSC (29,704{+-}6,659 picomole/10{sup 6} cells) was greater than that in adeno-hNIS-rMSC at MOI 100 (6,168{+-}2,134 picomole/10{sup 6} cells). Despite lower amount of expressed protein, hNIS function in rMSC was greater by lentivirus than by adenovirus mediated expression. Stem cell tracking using hNIS as a reporter gene should be conducted in consideration of relative vector efficiency for transgene expression.

  12. Comparison of Human Sodium/Iodide Symporter (hNIS) Gene Expressions between Lentiviral and Adenoviral Vectors in Rat Mesenchymal Stem Cells

    International Nuclear Information System (INIS)

    Park, So Yeon; Lee, Won Woo; Kim, Hyun Joo; Chung, June Key; Kim, Sang Eun; Kim, Sung Jin; Lee, Heui Ran

    2008-01-01

    Quantitative comparison of transgene expression within stem cells between lentivirus and adenovirusmediated delivery systems has not been reported. Here, we evaluated the human sodium iodide symporter (hNIS) gene expression in rat mesenchymal stem cell (rMSC) transduced by lentivirus or adenovirus, and compared the hNIS expression quantitatively between the two delivery systems. Lentiviral-mediated hNIS expressing rMSC (lenti-hNIS-rMSC) was constructed by cloning hNIS gene into pLenti6/UbC/V5-DEST (Invitrogen) to obtain pLenti-hNIS, transducing rMSC with the pLenti-hNIS, and selecting with blasticidin for 3 weeks. Recombinant adenovirus expressing hNIS gene (Rad-hNIS) was produced by homologous recombination and transduction efficiency of Rad-hNIS into rMSC evaluated by Rad-GFP was 19.1±4.7%, 54.0±6.4%, 85.7±8.7%, and 98.4±1.3% at MOI 1, 5, 20, and 100, respectively. The hNIS expressions in lenti-hNIS-rMSC or adeno-hNIS-rMSC were assessed by immunocytochemistry, western blot, and I-125 uptake. Immunocytochemistry and western blot analyses revealed that hNIS expressions in lenti-hNIS-rMSC were greater than those in adeno-hNIS-rMSC at MOI 20 but lower than at MOI 50. However in vitro I-125 uptake test demonstrated that iodide uptake in lenti-hNIS-rMSC (29,704±6,659 picomole/10 6 cells) was greater than that in adeno-hNIS-rMSC at MOI 100 (6,168±2,134 picomole/10 6 cells). Despite lower amount of expressed protein, hNIS function in rMSC was greater by lentivirus than by adenovirus mediated expression. Stem cell tracking using hNIS as a reporter gene should be conducted in consideration of relative vector efficiency for transgene expression

  13. Comparison of NIS and NHIS/NIPRCS vaccination coverage estimates. National Immunization Survey. National Health Interview Survey/National Immunization Provider Record Check Study.

    Science.gov (United States)

    Bartlett, D L; Ezzati-Rice, T M; Stokley, S; Zhao, Z

    2001-05-01

    The National Immunization Survey (NIS) and the National Health Interview Survey (NHIS) produce national coverage estimates for children aged 19 months to 35 months. The NIS is a cost-effective, random-digit-dialing telephone survey that produces national and state-level vaccination coverage estimates. The National Immunization Provider Record Check Study (NIPRCS) is conducted in conjunction with the annual NHIS, which is a face-to-face household survey. As the NIS is a telephone survey, potential coverage bias exists as the survey excludes children living in nontelephone households. To assess the validity of estimates of vaccine coverage from the NIS, we compared 1995 and 1996 NIS national estimates with results from the NHIS/NIPRCS for the same years. Both the NIS and the NHIS/NIPRCS produce similar results. The NHIS/NIPRCS supports the findings of the NIS.

  14. MPC&A training needs of the NIS/Baltics States.

    Energy Technology Data Exchange (ETDEWEB)

    Beck, David Franklin; Stoy-McLeod, Carol L.

    2006-07-01

    This report serves to document contract deliverables considered to be of continuing interest associated with two workshops conducted as part of an initial assessment of Material Protection, Control, and Accounting (MPC&A) training needs of the Newly Independent and Baltic States (NIS/Baltics). These workshops were held in Kiev, Ukraine, ca. 2003-2004, with the assistance of personnel from the George Kuzmycz Training Center (GKTC) of the Kiev Institute of Nuclear Research (KINR). Because of the dominant role Ukraine plays in the region in terms of the nuclear industry, one workshop focused exclusively on Ukrainian training needs, with participants attending from twelve Ukrainian organizations (plus U.S. DOE/NNSA representatives). The second workshop included participation by a further ten countries from the NIS/Baltics region. In addition, the training needs data developed during the workshop were supplemented by the outcomes of surveys and studies conducted by the GKTC.

  15. SPECT Imaging for in vivo tracking of NIS containing stem cells

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Zhenghong

    2013-04-02

    Na+/I- symporter (NIS) gene as a reporter gene (imagene) for non-invasive imaging of infused stem cells distribution and persistence in vivo on small animal models. NIS is an intrinsic membrane glycoprotein that mediates active iodide (I-) uptake into normal thyroid follicular cells and other cells. The advantages of using NIS for non-invasive and repeated scintigraphic imaging in this application are: a) NIS is not a foreign gene and thus eliminate the immunoresponse problem; b) radiotracer or substrate for NIS is simply radioiodide (I-125, I- 123, I-124, and I-124) or [Tc-99m]-pertechnetate, no radiosynthesis is needed. It has been shown that NIS gene transfer can induce radioactive iodide uptake in a variety of cells and that xenografts expressing exogenous NIS could be imaged by non-invasive scintigraphic imaging. The specific aims are: 1.Determine the feasibility, stability and physiological effects of human NIS gene expression on human HSCs and MSCs in vitro. 2.Determine the engraftment of human HSC and MSC co-infused in NOD-SCID mice. 3.Transduce both a drug resistance gene and an imagene into bone marrow stem cells, and follow the dynamics of engraftment after selection in real time.

  16. 'NiNis': Youth in Argentina who Neither Work nor Study. A Social Integration Deficit

    Directory of Open Access Journals (Sweden)

    Lidia de la Torre

    2017-01-01

    Full Text Available This study aims to assess the extent to which vulnerability in household material living conditions affects the institutional integration of young people of Argentina. We worked with a random sample of 4,855 youth aged between 18 and 25. It was observed that 66% of those who neither study nor work live in households having a low or very low socioeconomic status, with 4 out of 10 of these youth residing in shantytowns or slums and with half of them failing to complete high school. Harsh environments create a vicious circle of persistent passivity and isolation. However, the comparison between the NiNis and the working segment allowed us to conclude that similar household levels of socio-economic vulnerability are not necessarily sufficient to explain the situation of social disaffiliation found in these youth NiNis.

  17. Discovery of aryl-tri-fluoroborates as potent sodium/iodide sym-porter (NIS) inhibitors

    International Nuclear Information System (INIS)

    Lecat-Guillet, N.; Ambroise, Y.

    2008-01-01

    The structure-based design of sodium/iodide sym-porter (NIS) inhibitors identified new active compounds. The organo-tri-fluoroborate shown was found to inhibit iodide uptake with an IC50 value of 0.4 μM on rat-derived thyroid cells. The biological activity is rationalized by the presence of the BF3 - ion as a minimal binding motif for substrate recognition at the iodide binding site. (authors)

  18. Discovery of aryl-tri-fluoroborates as potent sodium/iodide sym-porter (NIS) inhibitors

    Energy Technology Data Exchange (ETDEWEB)

    Lecat-Guillet, N.; Ambroise, Y. [CEA, DSV, Dept Bioorgan Chem and Isotop Labelling, Inst Biol and Technol, iBiTecS, F-91191 Gif Sur Yvette (France)

    2008-07-01

    The structure-based design of sodium/iodide sym-porter (NIS) inhibitors identified new active compounds. The organo-tri-fluoroborate shown was found to inhibit iodide uptake with an IC50 value of 0.4 {mu}M on rat-derived thyroid cells. The biological activity is rationalized by the presence of the BF3{sup -} ion as a minimal binding motif for substrate recognition at the iodide binding site. (authors)

  19. Facile synthesis of NiS anchored carbon nanofibers for high-performance supercapacitors

    Science.gov (United States)

    Xu, Jinling; Zhang, Li; Xu, Guancheng; Sun, Zhipeng; Zhang, Chi; Ma, Xin; Qi, Chunling; Zhang, Lu; Jia, Dianzeng

    2018-03-01

    Transition metal sulfide compounds with carbon materials are promising for high-performance supercapacitors. Carbon nanofibers (CNFs) wrapped with NiS nanoparticles were herein obtained through electrospinning and calcination. NiS nanoparticles in composite nanofibers are covered by a layer of graphitic carbon, which not only increase the conductivity but also provide active regions for nanoparticle growth to prevent aggregation. The CNFs-NiS electrode has high specific capacity of 177.1 mAh g-1 at 1 A g-1 (0.41 mAh cm-2 at a current density of 2.3 mA cm-2) and long-term cycling stability, with 88.7% capacitance retention after 5000 cycles. The excellent electrochemical activity may be attributed to the accessible specific surface, unique porous structure of CNFs and high specific capacitance of NiS. In addition, the asymmetric supercapacitor has an enhanced volumetric energy density of 13.32 mWh cm-3 at a volumetric power density of 180 mW cm-3 and high cycling stability, with 89.5% capacitance retention after 5000 cycles. It also successfully lights up a light-emitting diode. The CNFs-NiS composite has significant potential applications in supercapacitor.

  20. Microwave-assisted synthesis of NiS2 nanostructures for supercapacitors and cocatalytic enhancing photocatalytic H2 production

    Science.gov (United States)

    Pang, Huan; Wei, Chengzhen; Li, Xuexue; Li, Guochang; Ma, Yahui; Li, Sujuan; Chen, Jing; Zhang, Jiangshan

    2014-01-01

    Uniform NiS2 nanocubes are successfully synthesized with a microwave-assisted method. Interestingly, NiS2 nanocubes, nanospheres and nanoparticles are obtained by controlling microwave reaction time. NiS2 nanomaterials are primarily applied to supercapacitors and cocatalytic enhancing photocatalytic H2 production. Different morphologies of NiS2 nanostructures show different electrochemical and cocatalytic enhancing H2 production activities. Benefited novel nanostructures, NiS2 nanocube electrodes show a large specific capacitance (695 F g−1 at 1.25 A g−1) and excellent cycling performance (the retention 93.4% of initial specific capacitance after 3000 cycles). More importantly, NiS2 nanospheres show highly cocatalytic enhancing photocatalytic for H2 evolution, in which the photocatalytic H2 production is up to 3400 μmol during 12 hours under irradiation of visible light (λ>420 nm) with an average H2 production rate of 283 μmol h−1. PMID:24389929

  1. Feasibility of a novel positive feedback effect of 131I-promoted Bac-Egr1-hNIS expression in malignant glioma via baculovirus

    International Nuclear Information System (INIS)

    Guo Rui; Tian Lipeng; Han Bing; Xu Haoping; Zhang Miao; Li Biao

    2011-01-01

    Purpose: As intracellular iodine is released rapidly, increased expression of sodium/iodide symporter (NIS) is required for effective radioiodine treatment of tumor. As Egr1 promoter is activated by 131 I and may promote human NIS (hNIS) expression, hNIS also induces 131 I uptake and activates Egr1, so the existence of a positive feedback effect of 131 I-promoted Egr1-hNIS expression is possible. Our purpose was to investigate the possible existence of this positive feedback effect through a series of in vitro pioneer studies. Method: Recombinant baculovirus (Bac-Egr1-hNIS) encoding the hNIS gene under the control of a radiation-inducible Egrl promoter was constructed. To test 131 I-promoted hNIS expression, human malignant glioma U87 cells were transfected with Bac-Egr1-hNIS, stimulated with or without 131 I; the expression of hNIS protein was detected by immunofluorescence and flow cytometry test. In addition, the uptake and efflux of 131 I were determined after the incubation of Bac-Egr1-hNIS-transfected U87 cells with or without 131 I. Results: Immunocytochemical staining and flow cytometry test showed a higher hNIS protein expression in Bac-Egr1-hNIS-transfected U87 cells with 131 I stimulation than in cells without stimulation. Bac-Egr1-hNIS-transfected U87 cells accumulated up to about 4.05 times of 131 I after 131 I stimulation. The amount of 131 I uptake in both groups showed a baculovirus dose-dependent manner. However, rapid efflux of radioactivity was observed in both groups, with 50% lost during the first 2 min after the 131 I-containing medium had been replaced by a nonradioactive medium. Conclusion: Our results indicated that an improved transgene expression of 131 I-stimulated hNIS in U87 cells using a baculovirus vector containing the Egr1 promoter is possible, and the increased expression of hNIS is responsible for a higher 131 I uptake. It might provide a reference for the existence of a positive feedback effect in 131 I-promoted Bac-Egr1-hNIS

  2. Expression of the Na+/l- symporter (NIS is markedly decreased or absent in gastric cancer and intestinal metaplastic mucosa of Barrett esophagus

    Directory of Open Access Journals (Sweden)

    Wapnir Irene L

    2007-01-01

    Full Text Available Abstract Background The sodium/iodide symporter (NIS is a plasma membrane glycoprotein that mediates iodide (I- transport in the thyroid, lactating breast, salivary glands, and stomach. Whereas NIS expression and regulation have been extensively investigated in healthy and neoplastic thyroid and breast tissues, little is known about NIS expression and function along the healthy and diseased gastrointestinal tract. Methods Thus, we investigated NIS expression by immunohistochemical analysis in 155 gastrointestinal tissue samples and by immunoblot analysis in 17 gastric tumors from 83 patients. Results Regarding the healthy Gl tract, we observed NIS expression exclusively in the basolateral region of the gastric mucin-producing epithelial cells. In gastritis, positive NIS staining was observed in these cells both in the presence and absence of Helicobacter pylori. Significantly, NIS expression was absent in gastric cancer, independently of its histological type. Only focal faint NIS expression was detected in the direct vicinity of gastric tumors, i.e., in the histologically intact mucosa, the expression becoming gradually stronger and linear farther away from the tumor. Barrett mucosa with junctional and fundic-type columnar metaplasia displayed positive NIS staining, whereas Barrett mucosa with intestinal metaplasia was negative. NIS staining was also absent in intestinalized gastric polyps. Conclusion That NIS expression is markedly decreased or absent in case of intestinalization or malignant transformation of the gastric mucosa suggests that NIS may prove to be a significant tumor marker in the diagnosis and prognosis of gastric malignancies and also precancerous lesions such as Barrett mucosa, thus extending the medical significance of NIS beyond thyroid disease.

  3. Electrochemically induced transformation of NiS nanoparticles into Ni(OH)2 in KOH aqueous solution toward electrochemical capacitors

    International Nuclear Information System (INIS)

    Hou Linrui; Yuan Changzhou; Li Diankai; Yang Long; Shen Laifa; Zhang Fang; Zhang Xiaogang

    2011-01-01

    Highlights: → NiS is synthesized by means of the H 2 O/CS 2 interface under hydrothermal treatment. → NiS itself owns poor electrochemical capacitance in 2 M KOH solution. → NiS is electrochemically induced and transformed into electroactive Ni(OH) 2 . → Ni(OH) 2 is responsible for good energy storage of the NiS in the KOH solution. → The new formed Ni(OH) 2 delivers large energy density at high rates. - Abstract: Nickel sulfide nanoparticles (NPs) are first synthesized by virtue of a unique H 2 O/CS 2 interface under mild hydrothermal treatment. Electrochemical data reveals that the as-synthesized NiS NPs themselves own poor supercapacitive behavior at initial cyclic voltammetry (CV) cycles in 2 M KOH solution, while a specific capacitance of 893 F g -1 can be surprisingly obtained at a current density of 5 A g -1 just after continuous 320 CV cycles. X-ray diffraction and Fourier transform infrared techniques demonstrate that what is really responsible for the good electrochemical capacitance in the KOH aqueous solution is the new electrochemically formed Ni(OH) 2 phase, rather than NiS NPs themselves. The Ni(OH) 2 is slowly formed during the continuous CV cycling process, in which the electrochemically induced phase transformation from NiS to Ni(OH) 2 phase takes place. Furthermore, the new Ni(OH) 2 phase demonstrates the great ability of delivering large specific capacitance at high rates.

  4. Determination of major sodium iodide symporter (NIS) inhibitors in drinking waters using ion chromatography with conductivity detector.

    Science.gov (United States)

    Cengiz, Mehmet Fatih; Bilgin, Ayse Kevser

    2016-02-20

    Goiter is an important health problem all over the world and iodine deficiency is its most common cause. Perchlorate, thiocyanate and nitrate (called as major NIS inhibitors) are known to competitively inhibit iodide uptake by the thyroid gland and thus, human exposure to major NIS inhibitors is a public health concern. In this study, an ion chromatographic method for the determination of most common NIS inhibitor ions in drinking waters was developed and validated. This is the first study where an analytical method is used for the determination of major NIS inhibitors in drinking water by an ion chromatography system in a single run. Chromatographic separations were achieved with an anion-exchange column and separated ions were identified by a conductivity detector. The method was found to be selective, linear, precise accurate and true for all of interested ions. The limits of the detections (LOD) were estimated at 0.003, 0.004 and 0.025mgL(-1) for perchlorate, thiocyanate and nitrate, respectively. Possible interference ions in drinking waters were examined for the best separation of NIS inhibitors. The excellent method validation data and proficiency test result (Z-score for nitrate: -0.1) of the FAPAS(®) suggested that the developed method could be applied for determination of NIS inhibitor residues in drinking waters. To evaluate the usefulness of the method, 75 drinking water samples from Antalya/Turkey were analyzed for NIS inhibitors. Perchlorate concentrations in the samples ranged from not detected (less than LOD) to 0.07±0.02mgL(-1) and the range of nitrate concentrations were found to be 3.60±0.01mgL(-1) and 47.42±0.40mgL(-1). No thiocyanate residues were detected in tested drinking water samples. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. Significance of mercury in environmental health - an overview; Bedeutung von Quecksilber in der Umweltmedizin - eine Uebersicht

    Energy Technology Data Exchange (ETDEWEB)

    Schweinsberg, F. [Chemisches Labor, Institut fuer Allgemeine Hygiene und Umwelthygiene, Tuebingen (Germany)

    2002-07-01

    werden tubulaere Nekrosen gesehen. Bei Patienten mit schwerer Nierenfunktionsstoerung sollte auf Amalgamfuellungen verzichtet werden. Durch Amalgamfuellungen koennen in seltenen Faellen allergische Reaktionen (Spaettyp-IV) und intraorale lichenoide Reaktionen (oraler Lichen ruber planus) ausgeloest werden. Der Nachweis subklinischer Effekte durch Amalgamfuellungen und deren gesundheitliche Bedeutung sind noch immer Gegenstand kontroverser Diskussionen. Die Zuordnung unspezifischer Symptome zu einer Quecksilberbelastung aus Amalgamfuellungen ist wissenschaftlich nicht fundiert moeglich. Eine chronische Erkrankung des Nervensystems durch organisches Quecksilber fuehrt zu Paraesthesie, Ataxie, Dysarthrie, Einschraenkung des Sehfeldes und zu Hoerverlusten. Die Belastung mit Quecksilber waehrend der Schwangerschaft, speziell aus Fischkonsum, ist besonders kritisch zu bewerten. Die gesundheitliche Bewertung von Quecksilberbelastungen erfolgt durch Ableitung von Human-Biomonitoring-Werten (HBM): Bei langzeitiger Exposition mit anorganischem Quecksilber ist ab dem HBM-II-Wert fuer Quecksilber im Urin von 25 {mu}g/l eine gesundheitliche Beeintraechtigung moeglich. Der entsprechende HBM-II-Wert fuer organisches Quecksilber im Blut liegt bei 15{mu}g/l, das entspricht einem Quecksilbergehalt in den Haaren von ca. 5 mg/kg. (orig.)

  6. Materijalna motivacija kao nosilac uspešne reorganizacije kompanije NIS (Material Motivation as the Holder of a Successful Reorganization on the Example of Company Nis

    Directory of Open Access Journals (Sweden)

    Radmila Stojanović

    2015-04-01

    Full Text Available For successful organization people are the primary development resource. Motivation and satisfaction of employees become the basis of modern organizations. Motivated employees today represent a strategic resource which gain a competitive advantage for the organization. If someone wants to motivate others, must first be able to motivate yourself. That means that if in organization exists motivated staff, there must be a motivated manager who will be able to launch employees. The aim of this paper is to emphasizes the importance of material motivation for successful business of a large company that had in the past significant organizational change. Through unstructured interviews were collected data on which was investigated the hypothesis that the material motivation of the most important holder for successful reorganization on the example of leading Serbian company for exploration, production and refining of oil and gas NIS. From the above it can be concluded that high-quality human resources management involves proper motivation system, that has been based on material incentives. In this paper, attention will be focused on monetary motivation and how a well-established system of material incentives can lead to the great success of the company that had a significant reorganization in the past. It will be shown in detail the system of material incentives and the positive results which obtained by this system, when it comes to the business of the company, which today is the most desirable employer in Serbia and the region. The paper should emphasize the benefits of a fair system of motivation which brings to an organization, but also to encourage further thinking to improve this aspect of motivation, which is a prerequisite for successful business and the basis for all other activities in the HRM. The analysis results indeed show that a system of material incentives in NIS is the holder of a successful reorganization, and the proof is the business

  7. Direct evidence of spin frustration in the fcc antiferromagnet NiS sub 2

    CERN Document Server

    Matsuura, M; Endoh, Y; Hirota, K; Yamada, K

    2002-01-01

    NiS sub 2 is a well-known Mott insulator with anomalous antiferromagnetic long-range order of coexistent type I (Q sub M =(1,0,0), T sub N sub 1 =40 K) and type II (Q sub M =(1/2,1/2,1/2), T sub N sub 2 =30 K). Extensive neutron-scattering measurements reveal that magnetism in NiS sub 2 is governed by geometrical spin frustration, resulting in magnetic diffuse scattering extending along the fcc zone boundary. Although the diffuse scattering exists at temperatures as high as 250 K (6T sub N sub 1), it disappears rapidly below T sub N sub 2 , associated with minor crystal distortion. We observed a clear energy gap in addition to the low-energy spin-wave excitation at significantly below 30 K, and obtain evidence that degeneracy due to the coexistence of the two types of antiferromagnetism is relieved in the ground state via the reduction in symmetry due to distortion. (orig.)

  8. A rapid NiS bead technique for measurements of picogram concentrations of platinum group elements (PGEs) following neutron activation

    International Nuclear Information System (INIS)

    Das, A.; Shukla, A.D.

    1999-01-01

    To measure picogram amounts of PGEs in terrestrial and extraterrestrial samples we have modified the NiS fire assay technique in conjunction with neutron activation analysis. Os, Ir and Ru are almost quantitatively concentrated in the NiS bead. The method should be applicable to other elements (Pt, Pd, and Rh) but these could not be analyzed because of the short half life of their daughter isotopes. The results also show that the chalcophhile elements like Ag also can be quantitatively estimated using this method. (author)

  9. Size-dependent and intra-band photoluminescence of NiS2 nano-alloys synthesized by microwave assisted hydrothermal technique

    CSIR Research Space (South Africa)

    Linganiso, C

    2013-03-01

    Full Text Available Synthesis of nickel disulfide (NiS2) nano-alloys capped and uncapped with hexadecylamine (HDA) was carried out. A cubic phase NiS2 formation was confirmed by X-ray diffraction (XRD) analysis. An average crystallite size of 35 nm was obtained...

  10. The acceleration intermediate phase (NiS and Ni3S2) evolution by nanocrystallization in Li/NiS2 thermal batteries with high specific capacity

    Science.gov (United States)

    Jin, Chuanyu; Zhou, Lingping; Fu, Licai; Zhu, Jiajun; Li, Deyi; Yang, Wulin

    2017-06-01

    The intermediate phase of NiS2 is thought to be a bottleneck currently to improve the overall performance of Li/NiS2 thermal batteries because of its low conductivity and close formation enthalpy between NiS2 and the intermediate phase (NiS, Ni3S2, etc). For improving the discharge performances of Li/NiS2 thermal batteries, the nano NiS2 with an average size of 85 ± 5 nm is designated as a cathode material. The electrochemical measurements show that the specific capacity of nano NiS2 cathode is higher than micro NiS2. The nano NiS2 cathode exhibits excellent electrochemical performances with high specific capacities of 794 and 654 mAh g-1 at current density of 0.1 and 0.5 A cm-2 under a cut-off voltage of 0.5 V, respectively. These results show that the rapid intermediate phase evolution from the nanocrystallization can obviously enhance use efficiency of NiS2 and improve discharge performances of thermal batteries.

  11. Imaging of adenovirus-mediated expression of human sodium iodide symporter (hNIS) by 99mTcO4 scan in mice

    International Nuclear Information System (INIS)

    Lee, Won Woo; Moon, D. H.; Park, S. Y.; Jin, J.; Kim, S. J.; Lee, H.

    2002-01-01

    We have evaluated the feasibility of human sodium iodide symporter (hNIS) as a reporter gene by 99m TcO 4 scan in vivo. Recombinant adenovirus encoding hNIS (Rad-hNIS) gene was introduced to FRO cell. hNIS expression was assessed by western blot and 99m TcO 4 uptake in vitro. 99m TcO 4 scan were obtained in BALB/c mice 48 hrs post injection of Tris buffer, Rad-hNIS (1x10 9 or 2x10 8 pfu), or Rad-LacZ (1x10 9 pfu) via the tail vein (n=5-7 for each group). Biodistribution study and RT-PCR were performed. A series of 99m TcO 4 scans were obtained in 2 mice until 21 days post Rad-hNIS injection. FRO readily expressed hNIS protein and incorporated significantly higher level of 99m TcO 4 in vitro. With 99m TcO 4 scan, prominent hepatic uptake was observed only in the mice with 1x10 9 pfu of Rad-hNIS. Liver/lung ratio was increased in this group from 15 (5.7±2.5) till 60 min(6.7±3.6) (p 99m TcO 4 uptake (22.7±11.2 %ID/g) and hNIS mRNA expression were exclusively noticed in livers of this group. The persistent hepatic uptake was observed for up one week. NaClO 4 inhibited the hepatic uptake of 99m TcO 4 . hNIS holds a promising potential as an effective reporter gene for noninvasive/repeated imaging in combination with 99m TcO 4

  12. Au-controlled enhancement of photoluminescence of NiS nanostructures synthesized via a microwave-assisted hydrothermal technique

    CSIR Research Space (South Africa)

    Linganiso, EC

    2014-11-01

    Full Text Available and confirmed by X-ray diffraction (XRD) studies. TEM analysis revealed that the NiS nanostructures were of various shapes. A quantum confinement effect was confirmed by the blue shift PL emissions and high optical energy band gap observed for the as...

  13. Metallic behavior of NiS thin film under the structural, optical, electrical and ab initio investigation frameworks

    Energy Technology Data Exchange (ETDEWEB)

    Boughalmi, R. [Unité de physique des dispositifs à semi-conducteurs, Faculté des sciences de Tunis, Tunis El Manar University, 2092 Tunis (Tunisia); Rahmani, R. [Laboratoire de Physique des Couches Minces et Matériaux pour l' Electronique (LPC2ME). Département de physique, Faculté des Sciences, Université d' Oran Es-Sénia, Oran (Algeria); Département de physique, Université des Sciences et de la Technologie d' Oran- Mohamed-Boudiaf, Oran (Algeria); Boukhachem, A., E-mail: abdelwaheb.boukhachem@laposte.net [Unité de physique des dispositifs à semi-conducteurs, Faculté des sciences de Tunis, Tunis El Manar University, 2092 Tunis (Tunisia); Amrani, B.; Driss-Khodja, K. [Laboratoire de Physique des Couches Minces et Matériaux pour l' Electronique (LPC2ME). Département de physique, Faculté des Sciences, Université d' Oran Es-Sénia, Oran (Algeria); Amlouk, M. [Unité de physique des dispositifs à semi-conducteurs, Faculté des sciences de Tunis, Tunis El Manar University, 2092 Tunis (Tunisia)

    2015-08-01

    Nickel sulfide (NiS) thin films were deposited on the glass substrates by spray pyrolysis at 250 °C using an aqueous solution which contains nickel chloride hexahydrate and thiourea as precursors. X-ray diffraction analysis confirms that the hexagonal structure is being part of P6{sub 3}/mmc space group of the deposited films with (100) preferred orientation and lattice parameters a = 3.441 Å and c = 5.320 Å. The optical properties, investigated through transmittance and reflectance measurements reveal that the direct band gap energy (Eg) is around 0.55 eV. The electrical study shows a metallic behavior of the current II-VI binary compound. This behavior regarding NiS II-VI binary sulfide was confirmed by numerical studies based on the density functional theory (DFT) were adopted. The ground state quantities, such as lattice parameter, bulk modulus and its pressure derivative as well as the elastic constants were obtained. The values are consistent with the stability of hexagonal structure. The band structure and the states densities of such material were studied. The results show that there is an agreement between experimental and simulation. - Highlights: • NiS thin films are synthesized by Spray pyrolysis. • NiS is a low band gap compound. • These films have interesting electrical properties showing a metallic behavior. • Computational study confirms the electrical measurements.

  14. Rhenium-188 as an alternative to Iodine-131 for treatment of breast tumors expressing the sodium/iodide symporter (NIS)

    International Nuclear Information System (INIS)

    Dadachova, E.; Bouzahzah, B.; Zuckier, L.S.; Pestell, R.G.

    2002-01-01

    The sodium-iodide symporter (NIS), which transports iodine into the cell, is expressed in thyroid tissue and was recently found to be expressed in approximately 80% of human breast cancers but not in healthy breast tissue. These findings raised the possibility that therapeutics targeting uptake by NIS may be used for breast cancer treatment. To increase the efficacy of such therapy it would be ideal to identify a radioactive therapy with enhanced local emission. The feasibility of using the powerful beta-emitting radiometal 188 Re in the form of 188 Re-perrhenate was therefore compared with 131 I for treatment of NIS-expressing mammary tumors. In the current studies, using a xenografted breast cancer model induced by the ErbB2 oncogene in nude mice, 188 Re-perrhenate exhibited NIS-dependent uptake into the mammary tumor. Dosimetry calculations in the mammary tumor demonstrate that 188 Re-perrhenate is able to deliver a dose 4.5 times higher than 131 I suggesting it may provide enhanced therapeutic efficacy

  15. [Tooth pathology analysis of osteological material from the Medieval locality of Saint Pantelejmon church in Nis].

    Science.gov (United States)

    Mitić, Nadica; Mitić, Aleksandar; Crnoglavac, Vesna; Vlak, Dejana; Nikolić, Marija

    2008-01-01

    Medieval necropolis at the porch of St. Panteleimon church in Nis, from 12th century represents a typical Serbian necropolis, which has its analogies in several areas in Serbia. Preservation of the skeletal remains belongs to category of good and medium preservation. The aim of the work was to study the skeletal remains for the prevalence of tooth caries, localization of caries lesions, presence of abrasion, supragingival tartar and resorption of alveolar bone as the indicator of periodontal disease. The analyses included 42 skeletal remains. The anthropological analyses involved paleopathological findings on 954 teeth of 22 men and 20 women. The pathological changes of teeth were determined by inspection, dental probe, dental mirror and x-ray examination. Epidemiological research was done using average caries index. The antropological tooth pathology research of osteological material from the medieval localization of St. Pantaleimon Church in Nis showed the presence of caries in 7.86% cases, 9.93% women and 6.07% men. In 76% caries were localized on the approximal surfaces of teeth. Abrasion of the second and third degree was registered on the side and front teeth with transformation of contact points into contact surfaces and the creation of approximal, interstitial, scolded surfaces. A large quantity of supragingival tartar was found in all individuals aged over 25 years. Expressed alveolar bone resorption is the indicator of generalized periodontal disease. The prevalence of caries in the studied medieval population from the 12th century was sporadic, with localization on secondary predilection places. The abrasion of the second and third degree was present, and the resorption of the alveolar bone was registered in all the examined skeletal remains, which was the indicator of spread periodontal disease in this period.

  16. Establishment of a hepatocellular carcinoma cell line expressing dual reporter genes: sodium iodide symporter (NIS) and enhanced green fluorescence protein (EGFP)

    International Nuclear Information System (INIS)

    Kwak, Won Jung; Koo, Bon Chul; Kwon, Mo Sun

    2007-01-01

    Dual reporter gene imaging has several advantages for more sophisticated molecular imaging studies such as gene therapy monitoring. Herein, we have constructed hepatoma cell line expressing dual reporter genes of sodium iodide symporter (NIS) and enhanced green fluorescence protein (EGFP), and the functionalities of the genes were evaluated in vivo by nuclear and optical imaging. A pRetro-PN vector was constructed after separating NIS gene from pcDNA-NIS. RSV-EGFP-WPRE fragment separated from pLNRGW was cloned into pRetro-PN vector. The final vector expressing dual reporter genes was named pRetro-PNRGW. A human hepatoma (HepG2) cells were transfected by the retrovirus containing NIS and EGFP gene (HepG2-NE). Expression of NIS gene was confirmed by RT-PCR, radioiodine uptake and efflux studies. Expression of EGFP was confirmed by RT-PCR and fluorescence microscope. The HepG2 and HepG2-NE cells were implanted in shoulder and hindlimb of nude mice, then fluorescence image, gamma camera image and I-124 microPET image were undertaken. The HepG2-NE cell was successfully constructed. RT-PCR showed NIS and EGFP mRNA expression. About 50% of cells showed fluorescence. The iodine uptake of NIS-expressed cells was about 9 times higher than control. In efflux study, T 1/2 of HepG2-NE cells was 9 min. HepG2-NE xenograft showed high signal-to-background fluorescent spots and higher iodine-uptake compared to those of HepG2 xenograft. A hepatoma cell line expressing NIS and EGFP dual reporter genes was successfully constructed and could be used as a potential either by therapeutic gene or imaging reporter gene

  17. Consistency of the national realization of dew-point temperature using NIS standard humidity generators

    Directory of Open Access Journals (Sweden)

    El-Galil Doaa Abd

    2017-01-01

    Full Text Available A comparison of two standard humidity generators (two-temperature (2-T and one-temperature (1-T generators that are developed by the National Institute for Standards (NIS has been performed using a transfer standard chilled-mirror hygrometer and measurement procedures to realize dew-point temperature Td in the range from −50 °C to 0 °C. The main objective of this comparison was to compare the realizations of dew-point temperature and to establish the level of consistency between the two generators. For a level of consistency between two measurements, it is expressed by the difference between the measured values, m1 − m2, and the expanded pair uncertainty of this difference Up [1]. The comparison measurements revealed dew-point temperature differences of 0.02 °C and 0.07 °C with expanded pair uncertainties of ±0.09 °C and ±0.15 °C.

  18. Power of tests for comparing trend curves with application to national immunization survey (NIS).

    Science.gov (United States)

    Zhao, Zhen

    2011-02-28

    To develop statistical tests for comparing trend curves of study outcomes between two socio-demographic strata across consecutive time points, and compare statistical power of the proposed tests under different trend curves data, three statistical tests were proposed. For large sample size with independent normal assumption among strata and across consecutive time points, the Z and Chi-square test statistics were developed, which are functions of outcome estimates and the standard errors at each of the study time points for the two strata. For small sample size with independent normal assumption, the F-test statistic was generated, which is a function of sample size of the two strata and estimated parameters across study period. If two trend curves are approximately parallel, the power of Z-test is consistently higher than that of both Chi-square and F-test. If two trend curves cross at low interaction, the power of Z-test is higher than or equal to the power of both Chi-square and F-test; however, at high interaction, the powers of Chi-square and F-test are higher than that of Z-test. The measurement of interaction of two trend curves was defined. These tests were applied to the comparison of trend curves of vaccination coverage estimates of standard vaccine series with National Immunization Survey (NIS) 2000-2007 data. Copyright © 2011 John Wiley & Sons, Ltd.

  19. Formation of Multiple-Phase Catalysts for the Hydrogen Storage of Mg Nanoparticles by Adding Flowerlike NiS.

    Science.gov (United States)

    Xie, Xiubo; Ma, Xiujuan; Liu, Peng; Shang, Jiaxiang; Li, Xingguo; Liu, Tong

    2017-02-22

    In order to enhance the hydrogen storage properties of Mg, flowerlike NiS particles have been successfully prepared by solvothermal reaction method, and are subsequently ball milled with Mg nanoparticles (NPs) to fabricate Mg-5 wt % NiS nanocomposite. The nanocomposite displays Mg/NiS core/shell structure. The NiS shell decomposes into Ni, MgS and Mg 2 Ni multiple-phases, decorating on the surface of the Mg NPs after the first hydrogen absorption and desorption cycle at 673 K. The Mg-MgS-Mg 2 Ni-Ni nanocomposite shows enhanced hydrogenation and dehydrogenation rates: it can quickly uptake 3.5 wt % H 2 within 10 min at 423 K and release 3.1 wt % H 2 within 10 min at 573 K. The apparent hydrogen absorption and desorption activation energies are decreased to 45.45 and 64.71 kJ mol -1 . The enhanced sorption kinetics of the nanocomposite is attributed to the synergistic catalytic effects of the in situ formed MgS, Ni and Mg 2 Ni multiple-phase catalysts during the hydrogenation/dehydrogenation process, the porthole effects for the volume expansion and microstrain of the phase transformation of Mg 2 Ni and Mg 2 NiH 4 and the reduced hydrogen diffusion distance caused by nanosized Mg. This novel method of in situ producing multiple-phase catalysts gives a new horizon for designing high performance hydrogen storage material.

  20. Growth, nisA Gene Expression, and In Situ Activity of Novel Lactococcus lactis subsp. cremoris Costarter Culture in Commercial Hard Cheese Production.

    Science.gov (United States)

    Noutsopoulos, Dimitrios; Kakouri, Athanasia; Kartezini, Eleftheria; Pappas, Dimitrios; Hatziloukas, Efstathios; Samelis, John

    2017-12-01

    This study evaluated in situ expression of the nisA gene by an indigenous, nisin A-producing (NisA+) Lactococcus lactis subsp. cremoris raw milk genotype, represented by strain M78, in traditional Greek Graviera cheeses under real factory-scale manufacturing and ripening conditions. Cheeses were produced with added a mixed thermophilic and mesophilic commercial starter culture (CSC) or with the CSC plus strain M78 (CSC+M78). Cheeses were sampled after curd cooking (day 0), fermentation of the unsalted molds for 24 h (day 1), brining (day 7), and ripening of the brined molds (14 to 15 kg each) for 30 days in a fully controlled industrial room (16.5°C; 91% relative humidity; day 37). Total RNA was directly extracted from the cheese samples, and the expression of nisA gene was evaluated by real-time reverse transcription PCR (qRT-PCR). Agar overlay and well diffusion bioassays were correspondingly used for in situ detection of the M78 NisA+ colonies in the cheese agar plates and antilisterial activity in whole-cheese slurry samples, respectively. Agar overlay assays showed good growth (>8 log CFU/g of cheese) of the NisA+ strain M78 in coculture with the CSC and vice versa. The nisA expression was detected in CSC+M78 cheese samples only, with its expression levels being the highest (16-fold increase compared with those of the control gene) on day 1, followed by significant reduction on day 7 and almost negligible expression on day 37. Based on the results, certain intrinsic and mainly implicit hurdle factors appeared to reduce growth prevalence rates and decrease nisA gene expression, as well as the nisin A-mediated antilisterial activities of the NisA+ strain M78 postfermentation. To our knowledge, this is the first report on quantitative expression of the nisA gene in a Greek cooked hard cheese during commercial manufacturing and ripening conditions by using a novel, rarely isolated, indigenous NisA+ L. lactis subsp. cremoris genotype as costarter culture.

  1. Imaging of adenovirus-mediated expression of human sodium iodide symporter (hNIS) by {sup 99m}TcO{sub 4} scan in mice

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Won Woo; Moon, D. H.; Park, S. Y.; Jin, J.; Kim, S. J.; Lee, H. [Ulsan University College of Medicine, Seoul (Korea, Republic of)

    2002-07-01

    We have evaluated the feasibility of human sodium iodide symporter (hNIS) as a reporter gene by {sup 99m}TcO{sub 4} scan in vivo. Recombinant adenovirus encoding hNIS (Rad-hNIS) gene was introduced to FRO cell. hNIS expression was assessed by western blot and {sup 99m}TcO{sub 4} uptake in vitro. {sup 99m}TcO{sub 4} scan were obtained in BALB/c mice 48 hrs post injection of Tris buffer, Rad-hNIS (1x10{sup 9} or 2x10{sup 8} pfu), or Rad-LacZ (1x10{sup 9} pfu) via the tail vein (n=5-7 for each group). Biodistribution study and RT-PCR were performed. A series of {sup 99m}TcO{sub 4} scans were obtained in 2 mice until 21 days post Rad-hNIS injection. FRO readily expressed hNIS protein and incorporated significantly higher level of {sup 99m}TcO{sub 4} in vitro. With {sup 99m}TcO{sub 4} scan, prominent hepatic uptake was observed only in the mice with 1x10{sup 9} pfu of Rad-hNIS. Liver/lung ratio was increased in this group from 15 (5.7{+-}2.5) till 60 min(6.7{+-}3.6) (p<0.01). Significantly increased {sup 99m}TcO{sub 4} uptake (22.7{+-}11.2 %ID/g) and hNIS mRNA expression were exclusively noticed in livers of this group. The persistent hepatic uptake was observed for up one week. NaClO{sub 4} inhibited the hepatic uptake of {sup 99m}TcO{sub 4}. hNIS holds a promising potential as an effective reporter gene for noninvasive/repeated imaging in combination with {sup 99m}TcO{sub 4}.

  2. Emotion und pädagogische Professionalität : Die Bedeutung des Umgangs mit Gefühlen für sozialpädagogische Berufe

    OpenAIRE

    Daßler, Henning

    1999-01-01

    Der Pädagogik im allgemeinen und der Sozialpädagogik im besonderen fällt es schwer, Kriterien und Möglichkeiten ihrer eigenen Professionalität zu definieren. Eine wesentliche Ursache dafür liegt in der Schwierigkeit, die emotionale Dimension des beruflichen Handelns in ihrer Bedeutung zu erkennen und in einer angemessenen Weise wissenschaftlich zu erschließen. Die ungenügende Beachtung von Emotion läßt sich in drei Bereichen aufzeigen: In der Analyse der gesellschaftlichen Veränderungen, die ...

  3. Correlates of HPV vaccine initiation and provider recommendation among male adolescents, 2014 NIS-Teen.

    Science.gov (United States)

    Landis, Kathryn; Bednarczyk, Robert A; Gaydos, Laura M

    2018-05-08

    Vaccination is a safe and effective way to prevent Human Papillomavirus (HPV) infection and related cancers; however, HPV vaccine uptake remains low in the US. After the 2011 Advisory Committee on Immunization Practices (ACIP) recommendation for routine HPV vaccination of adolescent males, several studies have examined predictors for initiating the vaccine series in this population of interest, particularly with regard to provider recommendations. This study examined racial and ethnic differences for HPV vaccine initiation and provider recommendation in male adolescents. Based on prior HPV vaccine uptake estimates and healthcare utilization data, we hypothesized that minority adolescents would be more likely to initiate HPV vaccines, but less likely to receive a provider recommendation compared to white counterparts. We analyzed the 2014 National Immunization Survey-Teen (NIS-Teen), which included 10,753 male adolescents with provider-verified vaccination data in 50 US states, using multivariate logistic regression models to evaluate racial/ethnic differences in HPV vaccine initiation and provider recommendation. The odds of HPV vaccine initiation were 76 percent higher for Hispanic adolescents and 43 percent higher for non-Hispanic Other or Multiple race adolescents compared to white adolescents. Approximately half of parents reported receiving a provider recommendation for vaccination, with no significant difference in the odds of receiving a provider recommendation across racial/ethnic groups. Despite similar frequency of recommendations across racial and ethnic groups, male adolescents who are racial/ethnic minorities are more likely to initiate vaccination. Future research should focus on developing tailored interventions to increase HPV vaccine receipt among males of all racial/ethnic groups. Copyright © 2018 Elsevier Ltd. All rights reserved.

  4. Incidence and significance of small focal liver lesions on MRI; Haeufigkeit und Bedeutung von kleinen fokalen Leberlaesionen in der MRT

    Energy Technology Data Exchange (ETDEWEB)

    Kreft, B.; Pauleit, D.; Bachmann, R.; Conrad, R.; Kraemer, A.; Schild, H.H. [Bonn Univ. (Germany). Radiologische Klinik

    2001-05-01

    Analysis of the frequency and significance of small focal liver lesions ({<=} 2 cm) detected on MRI in the presence or absence of a history of malignancy. Methods: 628 MRI examinations of the liver performed during 1994 - 1996 were evaluated. The inclusion criterion into the study was the detection of a focal liver lesion with a size {<=} 2 cm. The frequency, the size, the diagnostic proof, and the differential diagnosis of the focal liver lesions were analysed with regard to the patients history of a known malignant tumor. Results: Overall, 179 of the 628 patients (28.5%) had focal liver lesions {<=} 2 cm (n = 338). 58.9% of the lesions could be classified based upon follow-up studies by ultrasound, CT or MRI, or by biopsy. The remaining 41.1% of the lesions could not be classified due to the absence of follow-up examinations. 57.3% of all proven lesions were benign and 42.7% were malignant. A history of a malignant tumor was present in 76.7% of all patients with small liver lesions; however, lesions were benign in these patients in 50.6% of the cases. In patients with no known history of a malignancy, 75% of the lesions were benign and 25% were malignant. However, these malignant lesions were in 10/11 cases hepatocellular carcinomas in patients with liver cirrhosis. (orig.) [German] Analyse der Haeufigkeit und der Bedeutung von kleinen Leberlaesionen ({<=} 2 cm) in der MRT in Abhaengigkeit einer vorbestehenden Tumoranamnese. Methode: Es wurden insgesamt 628 MRT-Untersuchungen der Leber aus dem Zeitraum von 1994-1996 ausgewertet. Einschlusskriterium in die Studie war der Nachweis von Leberlaesionen mit einer Groe paragraph e {<=} 2 cm, wobei die Haeufigkeit, die Groe paragraph enverteilung, die Diagnosesicherung und die Differenzialdiagnose in Abhaengigkeit von der Anamnese einer Tumorerkrankung untersucht wurden. Ergebnisse: Insgesamt wiesen 179 der 628 Patienten (28,5%) fokale Leberlaesionen {<=} 2 cm (n = 338) auf. 58,9% der Laesionen konnten aufgrund von

  5. The brown coal open mining. Significance, planning, operation, technology, environment; Der Braunkohlentagebau. Bedeutung, Planung, Betrieb, Technik, Umwelt

    Energy Technology Data Exchange (ETDEWEB)

    Niemann-Delius, Christian [RWTH Aachen (Germany). Inst. fuer Rohstoffgewinnung ueber Tage und Bohrtechnik; Drebenstedt, Carsten [TU Freiberg (Germany). Inst. Bergbau und Spezialtiefbau; Muellensiefen, Klaus (eds.) [RWE Power AG, Bergheim-Niederaussem (Germany). Sparte Tagebau; Stoll, Rolf Dieter

    2009-07-01

    The book under consideration deals with the general complex of the production of brown coal in the open mining considering the actual state of the art in theory and practice. A current monograph of this kind does not exist at present. Therefore, the publishers have the goal, to work on and arrange a general survey of the topic in particular in the background of a clearly greater importance of the lignite mining in the federal Republic of Germany. The technical book generally is addressed to persons who want to get a comprehensive overview according to the sector of raw material extraction and energy industry. The emphasis of the view is on the large producing districts in the Federal Republic of Germany: Lausitz, Central Germany and Rhineland. With few examples, the authors also report on other interesting aspects of production techniques outside of the Federal Republic of Germany. The topics reach from the development of deposits over the planning preparation of the brown coal production including the legal fundaments, the operation and the technology up to the aspects of the resettlement and recultivation as well as environmental protection. [German] ''Der Braunkohlentagebau'' behandelt den Gesamtkomplex der Gewinnung von Braunkohle im Tagebau zum heutigen Stand in Theorie und Praxis. Eine aktuelle Monographie dieser Art gibt es derzeit nicht. Daher haben sich die Herausgeber das Ziel gesetzt, die erforderliche Gesamtschau des Themas zu bearbeiten und zusammenzustellen und dies insbesondere vor dem Hintergrund einer deutlich groesseren Bedeutung des Braunkohlenbergbaus im vereinigten Deutschland. Das vorliegende Fachbuch richtet sich ganz allgemein an Personen, die sich einen umfassenden Ueberblick ueber diesen Sektor der Rohstoffgewinnung und der Energiewirtschaft verschaffen wollen. Im Besonderen soll es Mitarbeitern, die bereits in den entsprechenden Unternehmen, in der Zulieferindustrie oder bei Genehmigungsbehoerden taetig sind, dienen

  6. Implementation of multiple intelligences theory in the English language course syllabus at the University of Nis Medical School.

    Science.gov (United States)

    Bakić-Mirić, Natasa

    2010-01-01

    Theory of multiple intelligences (MI) is considered an innovation in learning the English language because it helps students develop all eight intelligences that, on the other hand, represent ways people understand the world around them, solve problems and learn. They are: verbal/linguistic, logical/mathematical, visual/spatial, bodily/kinaesthetic, musical/rhythmic, interpersonal, intrapersonal and naturalist. Also, by focusing on the problem-solving activities, teachers, by implementing theory of multiple intelligences, encourage students not only to build their existing language knowledge but also learn new content and skills. The objective of this study has been to determine the importance of implementation of the theory of multiple intelligences in the English language course syllabus at the University of Nis Medical School. Ways in which the theory of multiple intelligences has been implemented in the English language course syllabus particularly in one lecture for junior year students of pharmacy in the University of Nis Medical School. The English language final exam results from February 2009 when compared with the final exam results from June 2007 prior to the implementation of MI theory showed the following: out of 80 junior year students of pharmacy, 40 obtained grade 10 (outstanding), 16 obtained grade 9 (excellent), 11 obtained grade 8 (very good), 4 obtained grade 7 (good) and 9 obtained grade 6 (pass). No student failed. The implementation of the theory of multiple intelligences in the English language course syllabus at the University of Nis Medical School has had a positive impact on learning the English language and has increased students' interest in language learning. Genarally speaking, this theory offers better understanding of students' intelligence and greater appreciation of their strengths. It provides numerous opportunities for students to use and develop all eight intelligences not just the few they excel in prior to enrolling in a

  7. The assessment of different models to predict solar module temperature, output power and efficiency for Nis, Serbia

    International Nuclear Information System (INIS)

    Pantic, Lana S.; Pavlović, Tomislav M.; Milosavljević, Dragana D.; Radonjic, Ivana S.; Radovic, Miodrag K.; Sazhko, Galina

    2016-01-01

    Five different models for calculating solar module temperature, output power and efficiency for sunny days with different solar radiation intensities and ambient temperatures are assessed in this paper. Thereafter, modeled values are compared to the experimentally obtained values for the horizontal solar module in Nis, Serbia. The criterion for determining the best model was based on the statistical analysis and the agreement between the calculated and the experimental values. The calculated values of solar module temperature are in good agreement with the experimentally obtained ones, with some variations over and under the measured values. The best agreement between calculated and experimentally obtained values was for summer months with high solar radiation intensity. The nonlinear model for calculating the output power is much better than the linear model and at the same time predicts better the total electrical energy generated by the solar module during the day. The nonlinear model for calculating the solar module efficiency predicts the efficiency higher than the STC (Standard Test Conditions) value of solar module efficiency for all conditions, while the linear model predicts the solar module efficiency very well. This paper provides a simple and efficient guideline to estimate relevant parameters of a monocrystalline silicon solar module under the moderate-continental climate conditions. - Highlights: • Linear model for solar module temperature gives accurate predictions for August. • The nonlinear model better predicts the solar module power than the linear model. • For calculating solar module power for Nis we propose the nonlinear model. • For calculating solar model efficiency for Nis we propose adoption of linear model. • The adopted models can be used for calculations throughout the year.

  8. Comparison of NiS2 and α-NiS hollow spheres for supercapacitors, non-enzymatic glucose sensors and water treatment.

    Science.gov (United States)

    Wei, Chengzhen; Cheng, Cheng; Cheng, Yanyan; Wang, Yan; Xu, Yazhou; Du, Weimin; Pang, Huan

    2015-10-21

    NiS2 hollow spheres are successfully prepared by a one-step template free method. Meanwhile, α-NiS hollow spheres can also be synthesized via the calcination of the pre-obtained NiS2 hollow spheres at 400 °C for 1 h in air. The electrochemical performances of the as-prepared NiS2 and α-NiS hollow sphere products are evaluated. When used for supercapacitors, compared with NiS2 hollow spheres, the α-NiS hollow sphere electrode shows a large specific capacitance of 717.3 F g(-1) at 0.6 A g(-1) and a good cycle life. Furthermore, NiS2 and α-NiS hollow spheres are successfully applied to fabricate non-enzymatic glucose sensors. In particular, the α-NiS hollow spheres exhibit good catalytic activity for the oxidation of glucose, a fast amperometric response time of less than 5 s, and the detection limit is estimated to be 0.08 μM. More importantly, compared with other normally co-existing interfering species, such as ascorbic acid, uric acid and dopamine, the electrode modified with α-NiS hollow spheres shows good selectivity. Moreover, the α-NiS hollow spheres also present good capacity to remove Congo red organic pollutants from wastewater by their surface adsorption ability.

  9. L-cysteine-assisted synthesis of hierarchical NiS2 hollow spheres supported carbon nitride as photocatalysts with enhanced lifetime

    Science.gov (United States)

    Zhu, Chengzhang; Jiang, Zhifeng; Chen, Linlin; Qian, Kun; Xie, Jimin

    2017-03-01

    Novel hierarchical NiS2 hollow spheres modified by graphite-like carbon nitride were prepared using a facile L-cysteine-assisted solvothermal route. The NiS2/g-C3N4 composites exhibited excellent photocatalytic efficiency in rhodamine B, methyl orange and ciprofloxacin degradation as compared to single g-C3N4 and NiS2, which could be due to the synergistic effects of the unique hollow sphere-like structure, strong visible-light absorption and increased separation rate of the photoinduced electron-hole pairs at the intimate interface of heterojunctions. A suitable combination of g-C3N4 with NiS2 showed the best photocatalytic performance. In addition, an electron spin resonance and trapping experiment demonstrated that the photogenerated hydroxyl radicals and superoxide radicals were the two main photoactive species in photocatalysis. A possible photocatalytic mechanism of NiS2/g-C3N4 composites under visible light irradiation is also proposed. The strategy presented here can be extended to a general strategy for constructing 3D/2D heterostructured photocatalysts for broad applications in photocatalysis.

  10. Enhanced iodide sequestration by 3-biphenyl-5,6-dihydroimidazo 2,1-b thiazole in sodium/iodide sym-porter (NIS)-expressing cells

    International Nuclear Information System (INIS)

    Lecat-Guillet, N.; Ambroise, Y.

    2008-01-01

    The ability of the sodium/iodide sym-porter (NIS) to take up iodide has long provided the basis for cyto-reductive gene therapy and cancer treatment with radio-iodide. One of the major limitations of this approach is that radio-iodide retention in NIS-expressing cells is not sufficient for their destruction. We identified and characterized a small organic molecule capable of increasing iodide retention in HEK293 cells permanently transfected with human NIS cDNA (hNIS-HEK293) and in the rat thyroid-derived cell line FRTL-5. In the presence of 3-biphenyl-4'-yl-5,6-dihydroimidazo[2,1-b)thiazole (ISA1), the transmembrane iodide concentration gradient was increased up to 4.5-fold. Our experiments indicate that the imidazo-thiazole derivative acts either by inhibiting anion efflux mechanisms, or by promoting the relocation of iodide into subcellular compartments. This new compound is not only an attractive chemical tool to investigate the mechanisms of iodide flux at the cellular level, but also opens promising perspectives in the treatment of cancer after NIS gene transfer. (authors)

  11. Size-dependent and intra-band photoluminescence of NiS2 nano-alloys synthesized by microwave assisted hydrothermal technique

    International Nuclear Information System (INIS)

    Linganiso, Ella Cebisa; Mhlanga, Sabelo Dalton; Coville, Neil John; Mwakikunga, Bonex Wakufwa

    2013-01-01

    Graphical abstract: Unexpected ultra-violet (UV) emission as well as near infra-red (IR) emissions were attributed to intra-band energy state transitions that occur as a result of the porous structure of the material. Enhanced UV and near IR PL emissions due to the smaller crystallite size of the capped NiS 2 nanostructures was also observed. Band energy and local density of states calculation for NiS 2 were used to support the experimentally observed luminescence results. The luminescence features at wavelengths of 400 nm (3.10 eV), 428 nm (2.90 eV), 447 nm (2.77 eV) and 464 nm (2.67) can be attributed to some of those electrons de-exciting from S (3p) levels down to the Ni (3d) (blue to UV emission) whereas those features at wavelengths of 710 nm (1.75 eV), 751 nm (1.65 eV), 754 nm (1.64 eV) [NiS 2 /HDA-capped NiS 2 ] and 784 nm (1.58 eV) respectively seem to result from de-excitations between either Ni(3d) or S (3s, 3p) levels and Ni–S hybridization levels (red to near IR emission). Highlights: ► Rapid solid state alloying of Ni and S from their liquid state precursor by microwaves. ► New photoluminescence data of NiS 2 system. ► Unexpected luminescence in the UV–Visible and near IR ranges for such a metal matrix alloy. ► Explanation of NiS 2 photoluminescence from ab initio calculations by electronic energy band structure and density of states. -- Abstract: Synthesis of nickel disulfide (NiS 2 ) nano-alloys capped and uncapped with hexadecylamine (HDA) was carried out. A cubic phase NiS 2 formation was confirmed by X-ray diffraction (XRD) analysis. An average crystallite size of 35 nm was obtained for the uncapped nanostructures and 9 nm was obtained for the capped nanostructures estimated using the Scherrer equation. Unexpected ultra-violet (UV) emission as well as near infrared (IR) emissions were attributed to intra-band energy state transitions that occur as a result of the porous structure of the material. Enhanced UV and near IR PL emissions

  12. Feasibility of dual reporter gene in rat myoblast cell line using human sodium iodide symporter (hNIS) and enhanced green fluorescent protein (EGFP) gene

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yong Jin; Lee, You La; Ahn, Sohn Joo; Choi, Chang Ik; Lee, Sang Woo; Ahn, Byeong Cheol; Lee, Jae Tae [School of Medicine, Kyungpook National University, Daegu (Korea, Republic of)

    2007-07-01

    To develop a non-invasive combined imaging method of gamma camera and optical imaging to assess rat myoblast cell line, H9c2, we constructed retrovirus containing hNIS and EGFP gene, and transfected to rat myoblast cell and monitored hNIS and EGFP expression. Rat myoblast cell line, H9C2, was transfected with hNIS and EGFP gene using retrovirus (H9C2-NG). The expression of hNIS and EGFP gene was determined by RT-PCR and fluorescence microscopy, respectively. The uptake and efflux of I-125 were measured in the transfected and wild type cell lines. Each cell line was injected to 4 flank sites (H9c2: 1X107 or 2X107, H9C2-NG: 1X107 or 2X107) in nude mouse. Scintigraphic image was performed at 3h, 1 day after H9C2 and H9C2-NG cell inoculation. We performed gamma camera and animal PET imaging to evaluate NIS expression. Also, GFP image obtained using optical imaging system. The expression of hNIS and EGFP gene was confirmed by RT-PCR. In iodide uptake, H9C2-NG cells accumulated 274.52.2 pmol/ mg protein at 30 min. But wild type cell line did not uptake iodide. In fluorescent microscopy, H9C2-NG cells were highly fluorescent than that of H9C2 cells. In iodide efflux study, 50% of radioactivity flowed out during the first 10min. Scintigraphy showed increased uptake of Tc-99m in H9c2-NG than in H9C2 for 1 day. Also, H9C2-NG cells showed high signal-to-background fluorescent spots in animal body. In this study, NIS and EGFP reporter gene were successfully transfected by a retrovirus in myoblast cell line, and the transfected cell can be easily visualized in vivo. These results suggest that NIS and EGFP gene has an excellent feasibility as a reporter gene, and it can be used to monitor cell trafficking for monitoring.

  13. FMEA Performed on the SPINLINE3 Operational System Software as part of the TIHANGE 1 NIS Refurbishment Safety Case

    International Nuclear Information System (INIS)

    Ristord, L.; Esmenjaud, C.

    2002-01-01

    This paper introduces the SPINLINE3 technology and TIHANGE 1 the NIS project. It then focuses on the specificity of FMEA performed on software. It points out the benefits of this analysis and also some of the limitations and possible developments. It also gives characteristics that, if present in the software, help the analysis and the defenses. It takes as an example the analysis performed on the Operational System Software of the Schneider Electric safety digital generic platform SPINLINE3. The New TIHANGE 1 Nuclear Instrumentation System successfully started operation on the beginning of Marsh 2001 after the plant outage, as planned at the beginning of the project. The choice of a software-based technology has raised the issue of the risk of CCF due to the same software being used in redundant independent units. Implementing functional diversity or equipment diversity has been considered but found either not practicable or of little value within this context. The safety characteristics of the SPINLINE3 solution and the stringent and proven safety software development process applied by the Nuclear department of the Schneider Electric company have made acceptable the principle of a design based on redundant identical processing units for this project. In addition, because of the possible consequences in case of the NIS not performing its protection function on demand, the licensing authority has required an FMEA oriented toward the SCCF risk as part of the safety case. This FMEA has been performed on : - the NIS architecture, - the SPINLINE3 Operational System Software, - the three Tihange 1 application software (i.e. source, intermediate and power range). The process used and the results have been elaborated by Schneider Electric and reviewed by the customer and the licensing authority all along the project development until final acceptance. Issues have been raised and answers and/or complementary analyses provided, some of them making direct references to the

  14. In situ synthesis of oriented NiS nanotube arrays on FTO as high-performance counter electrode for dye-sensitized solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Li, Yan, E-mail: liyan-nwnu@163.com [Key Laboratory of Atomic and Molecular Physics & Functional Materials of Gansu Province, College of Physics and Electronic Engineering, Northwest Normal University, Lanzhou, 730070 (China); Chang, Yin [Key Laboratory of Atomic and Molecular Physics & Functional Materials of Gansu Province, College of Physics and Electronic Engineering, Northwest Normal University, Lanzhou, 730070 (China); Zhao, Yun [Laboratory of Clean Energy Chemistry and Materials, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000 (China); Wang, Jian; Wang, Cheng-wei [Key Laboratory of Atomic and Molecular Physics & Functional Materials of Gansu Province, College of Physics and Electronic Engineering, Northwest Normal University, Lanzhou, 730070 (China)

    2016-09-15

    Oriented nickel sulfide (NiS) nanotube arrays were successfully in-situ fabricated on conductive glass substrate and used directly as counter electrode for dye-sensitized solar cells without any post-processing. Compared with Pt counter electrode, for the beneficial effect of electronic transport along the axial direction through the arrays to the substrate, oriented NiS nanotube arrays exhibit both higher electrocatalytic activity for I{sub 3}{sup −} reduction and better electrochemical stability, resulting in a significantly improved power conversion efficiency of 9.8%. Such in-situ grown oriented sulfide semiconductor nanotube arrays is expected to lead a new class structure of composites for highly efficient cathode materials. - Highlights: • In-situ synthesis strategy was proposed to construct oriented NiS nanotube arrays. • Such oriented tube nanostructure benefits the electronic transport along the axial direction of the arrays. • As CE of DSSCs, NiS nanotube arrays exhibit both higher efficiency (9.8%) and electrochemical stability than Pt.

  15. Report on the degradation of the environment at the site of NIS Novi Sad oil refinery and remediation measures

    International Nuclear Information System (INIS)

    Pavlovic, P.; Pavlovic, M.; Ivankovic, M.; Sokolovic, S.

    2002-01-01

    Before the NATO bombing, Refinery had available 149 tanks for the storage of crude oil, intermediate and final products, additives etc. All tanks are placed within the impermeable embankments of concrete or soil and connected to the storm and oil sewerage systems which enables the monitoring and control of of oil leakage and storm waste. During the NATO bombing practically all processing units were either destroyed or damaged. The summary of damages inflicted to the processing units is given. During the NATO bombing campaign over 51% of the available storage capacity was destroyed and over 34% of it was severely damaged. A summary of available, destroyed and damaged tank capacities in the NIS Novi Sad Oil Refinery is given. (author)

  16. Inhibition of miR-146b expression increases radioiodine-sensitivity in poorly differential thyroid carcinoma via positively regulating NIS expression

    Energy Technology Data Exchange (ETDEWEB)

    Li, Luchuan; Lv, Bin; Chen, Bo [Department of General Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012 (China); Guan, Ming [Department of General Surgery, Qihe People' s Hospital, Qihe, Shandong 251100 (China); Sun, Yongfeng [Department of General Surgery, Licheng District People' s Hospital, Jinan, Shandong 250115 (China); Li, Haipeng [Department of General Surgery, Caoxian People' s Hospital, Caoxian, Shandong 274400 (China); Zhang, Binbin; Ding, Changyuan; He, Shan [Department of General Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012 (China); Zeng, Qingdong, E-mail: qingdz0201@163.com [Department of General Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012 (China)

    2015-07-10

    Dedifferentiated thyroid carcinoma (DTC) with the loss of radioiodine uptake (RAIU) is often observed in clinical practice under radioiodine therapy, indicating the challenge for poor prognosis. MicroRNA (miRNA) has emerged as a promising therapeutic target in many diseases; yet, the role of miRNAs in RAIU has not been generally investigated. Based on recent studies about miRNA expression in papillary or follicular thyroid carcinomas, the expression profiles of several thyroid relative miRNAs were investigated in one DTC cell line, derived from normal DTC cells by radioiodine treatment. The top candidate miR-146b, with the most significant overexpression profiles in dedifferentiated cells, was picked up. Further research found that miR-146b could be negatively regulated by histone deacetylase 3 (HDAC3) in normal cells, indicating the correlation between miR-146b and Na{sup +}/I{sup −} symporter (NIS)-mediated RAIU. Fortunately, it was confirmed that miR-146b could regulate NIS expression/activity; what is more important, miR-146b interference would contribute to the recovery of radioiodine-sensitivity in dedifferentiated cells via positively regulating NIS. In the present study, it was concluded that NIS-mediated RAIU could be modulated by miR-146b; accordingly, miR-146b might serve as one of targets to enhance efficacy of radioactive therapy against poorly differential thyroid carcinoma (PDTC). - Highlights: • Significant upregulated miR-146b was picked up from thyroid relative miRNAs in DTC. • MiR-146b was negatively regulated by HDAC3 in normal thyroid carcinoma cells. • NIS activity and expression could be regulated by miR-146b in thyroid carcinoma. • MiR-146b inhibition could recover the decreased radioiodine-sensitivity of DTC cells.

  17. In situ preparation of NiS2/CoS2 composite electrocatalytic materials on conductive glass substrates with electronic modulation for high-performance counter electrodes of dye-sensitized solar cells

    Science.gov (United States)

    Li, Faxin; Wang, Jiali; Zheng, Li; Zhao, Yaqiang; Huang, Niu; Sun, Panpan; Fang, Liang; Wang, Lei; Sun, Xiaohua

    2018-04-01

    The electrocatalytic composite materials of honeycomb structure NiS2 nanosheets loaded with metallic CoS2 nanoparticles are in situ prepared on F doped SnO2 conductive glass (FTO) substrates used as counter electrodes of DSSCs through chemical bath deposition (CBD) and sulfidizing process. Single crystalline NiS2 honeycomb structure array lay a foundation for the large surface area of NiS2/CoS2 composite CEs. The formed NiS2/CoS2 nanointerface modulates electronic structure of composite CEs from the synergetic interactions between CoS2 nanoparticles and NiS2 nanosheets, which dramatically improves the electrocatalytic activity of NiS2/CoS2 composite CEs; Metallic CoS2 nanoparticles covering NiS2 nanosheets electrodes adjusts the electrodes' structure and then reduces the series resistance (Rs) and the Nernst diffusion resistance (Zw) of counter electrodes. The improvement of these areas greatly enhances the electrocatalytic performance of CEs and the short circuit current density (Jsc) and Fill factor (FF) of DSSCs. Impressively, the DSSC based on NiS2/CoS2-0.1 CE shows the best photovoltaic performance with photovoltaic conversion efficiency of 8.22%, which is 24.36% higher than that (6.61%) of the DSSC with Pt CE. And the NiS2/CoS2-0.1 CE also displays a good stability in the iodine based electrolyte. This work indicates that rational construction of composite electrocatalytic materials paves an avenue for high-performance counter electrodes of DSSCs.

  18. [Tooth macromorphological and ultrastructural analysis of osteological material from the medieval locality of St. Panteleimon Church in Nis].

    Science.gov (United States)

    Mitić, Nadica; Mitić, Aleksandar; Mitić, Vladimir; Savić, Vojin; Nikolić, Marija

    2010-01-01

    Analysis of macromorphological and ultrastructural tooth characteristics of osteological material from the medieval site of St. Pantaleimon Church in Nis provides us with insight on the life, nutrition and habits of medieval population, as well as the structure and composition of their teeth. The aim of this research, based on the tooth inspection of skeletal remains from the medieval site of St. Pantaleimon Church in Nis, was to analyze macromorphological characteristics, ultrastructure of the dental tissue of maxillary and mandibular molars, canines and incisors, as well as their chemical composition. Macromorphological and ultrastructural analysis of the dental tissue of osteological material dating from the 12th century included 1312 teeth with advanced abrasion. Macromorphological changes were detected by using a dental mirror, probe and radiography. After irrigation, the teeth were prepared using the standard procedure and analyzed by scanning electronic microscopy (JEOL-JSM-5300). Chemical analysis was done by expanded downscaling (EDS) method for Mg, P, Ca. The analysis detected second degree abrasions of all teeth in individuals aged 20-25 years. Third and fourth degree abrasions of teeth were detected in individuals aged over 40 years. Ultrastructural analysis showed a complete obliteration of dentin tubules and pulp of the lower incisors, the apposition of intratubular dentin inside the tubules, as well as extensive deformity and loss of dentin structure on molars with preserved pulp volume and nerve fiber calcification. The calcification of nerve fibers showed that the formation of intratubular dentin was proportional with the biological potential of pulp and the degree of abrasion, and inversely proportional with the size of dentin surface. Chemical analysis showed that in the analyzed teeth Ca composition was slightly lower than that in the control group, P composition was almost identical, while Mg composition was multiply increased in comparison to

  19. Non-verbal Communication in a Neonatal Intensive Care Unit: A Video Audit Using Non-verbal Immediacy Scale (NIS-O).

    Science.gov (United States)

    Nimbalkar, Somashekhar Marutirao; Raval, Himalaya; Bansal, Satvik Chaitanya; Pandya, Utkarsh; Pathak, Ajay

    2018-05-03

    Effective communication with parents is a very important skill for pediatricians especially in a neonatal setup. The authors analyzed non-verbal communication of medical caregivers during counseling sessions. Recorded videos of counseling sessions from the months of March-April 2016 were audited. Counseling episodes were scored using Non-verbal Immediacy Scale Observer Report (NIS-O). A total of 150 videos of counseling sessions were audited. The mean (SD) total score on (NIS-O) was 78.96(7.07). Female counseled sessions had significantly higher proportion of low scores (p communication skills in a neonatal unit. This study lays down a template on which other Neonatal intensive care units (NICUs) can carry out gap defining audits.

  20. Phase I Trial of Intratumoral Administration of NIS-Expressing Strain of Measles Virus in Unresectable or Recurrent Malignant Peripheral Nerve Sheath Tumor

    Science.gov (United States)

    2017-10-01

    AWARD NUMBER: W81XWH-15-1-0115 TITLE: Phase I Trial of Intratumoral Administration of NIS-Expressing Strain of Measles Virus in Unresectable or...Fort Detrick, Maryland 21702-5012 DISTRIBUTION STATEMENT: Approved for Public Release; Distribution Unlimited REPORT DOCUMENTATION PAGE Form...Approved OMB No. 0704-0188 Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time

  1. Die Arbeitswelt des Epigraphikers. Historische Hilfswissenschaft und ihre Bedeutung für Geschichte und Wissenschaft – ein römischer Erfahrungsbericht

    Directory of Open Access Journals (Sweden)

    Paul Sebastian Moos

    2012-05-01

    Full Text Available The column „Blick in die Historikerwerkstatt“ (A Glance into the Historian’s Workshop brings us on a journey to Germany’s oldest historical institute abroad, the German Historical Institute (DHI, in Rome, Italy. Since the institute was founded in 1888, historians have been actively at work, researching the history and development of German-Italian relations. Dr. Eberhard J. Nikitsch with the support of his student assistant Paul Sebastian Moos carries out intercultural research, working especially with epigraphic sources. In their report „Die Arbeitswelt des Epigraphikers. Historische Hilfswissenschaft und ihre Bedeutung für Geschichte und Wissenschaft – ein römischer Erfahrungsbericht“ (The Working World of the Epigrapher. The Historical Auxiliary Sciences and Their Significance for Historical and Academic Studies – a Roman Experience Report, the two historians outline their work, describe the various steps an epigrapher goes through, and locate their auxiliary science within modern historical and cultural studies. This report not only underlines the tremendous significance that is assigned to the study of inscriptions, but also provides the reader with an informative overview of the working environment of an epigrapher at the German Historical Institute in Rome.

  2. A two-step hydrothermal synthesis approach to synthesize NiCo2S4/NiS hollow nanospheres for high-performance asymmetric supercapacitors

    Science.gov (United States)

    Xu, Rui; Lin, Jianming; Wu, Jihuai; Huang, Miaoliang; Fan, Leqing; He, Xin; Wang, Yiting; Xu, Zedong

    2017-11-01

    In this work, a high-performance asymmetric supercapacitor device based on NiCo2S4/NiS hollow nanospheres as the positive electrode and the porous activated carbon as the negative electrode was successfully fabricated via a facile two-step hydrothermal synthesis approach. This NiCo2S4/NiS//activated carbon asymmetric supercapacitor achieved a high energy density of 43.7 Wh kg-1 at a power density of 160 W kg-1, an encouraging specific capacitance of 123 F g-1 at a current density of 1 mA cm-2, as well as a long-term performance with capacitance degradation of 5.2% after 3000 consecutive cycles at 1 mA cm-2. Moreover, the NiCo2S4/NiS electrode also demonstrated an excellent specific capacitance (1947.5 F g-1 at 3 mA cm-2) and an outstanding cycling stability (retaining 90.3% after 1000 cycles). The remarkable electrochemical performances may be attributed to the effect of NiS doping on NiCo2S4 which could enlarge the surface area and increase the surface roughness.

  3. Geothermal energy use in terms of a more balanced & sustainable urban-rural development of Southeast Serbia, with focus on Nis region

    Directory of Open Access Journals (Sweden)

    Jovanović Aleksandar

    2017-01-01

    Full Text Available The surrounding of Nis has been known for various geothermal manifestations (see Figure 3 and 4. The city itself has direct use of Nis Spa, where a couple of sites have been used for balneology and where heating systems have been installed. However, other local resources in Nis surrounding are little known. Also, Sokobanja has a long history of thermal waters 'use throughout its rich history, from the Antiquity throughout the middle ages and Turkish rule. This is also present in towns of Bela Palanka and Svrljig in South-East Serbian region surrounding Nis. These resources can be used for supplying the cities and villages with heat in the future. More importantly, communities in local towns in the region can be supported by more proficient use of geothermal potentials, as this idea supports the alleviated concentration of inhabitants in the region. It supports local renewable energy sources and a greater ration between potentials and actual use of geothermal sources, which tends to be very low in Serbian cities and rural places. In this paper, these resources are going to be presented, for the community in Serbia to have an insight and to be reminded of its potentials and significance for regional development and local resource utilization. Built heritage and urban-architectural wholes in some of these towns and in the villages, are neglected and geothermal resources in their vicinity underused. A more organized use of geothermal potentials can lead to their regenerations. It can support the idea of a more balanced rural-urban development of the region of Nis. However, geothermal energy can also be beneficial for future regional energy planning and cooperation between towns and villages in South-Eastern Serbian regions like Nis region. And this can be an important strategy in regional planning and energy planning for the future, once the economic crisis would stop to prevail in Serbia. The authors of this paper point out to the long

  4. Observation of the structural, optical and magnetic properties during the transformation from hexagonal NiS nano-compounds to cubic NiO nanostructures due to thermal oxidation

    Energy Technology Data Exchange (ETDEWEB)

    Linganiso, E.C., E-mail: elinganiso@csir.co.za [National Centre for Nano-Structured Materials, Council for Scientific and Industrial Research, P.O. Box 395, Pretoria 0001 (South Africa); DST/NRF Centre of Excellence in Strong Materials, Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, Johannesburg, Wits 2050 (South Africa); Mwakikunga, B.W., E-mail: bmwakikunga@csir.co.za [National Centre for Nano-Structured Materials, Council for Scientific and Industrial Research, P.O. Box 395, Pretoria 0001 (South Africa); Coville, N.J. [DST/NRF Centre of Excellence in Strong Materials, Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, Johannesburg, Wits 2050 (South Africa); Mhlanga, S.D. [Department of Applied Chemistry, University of Johannesburg, PO Box 17011, Doornfontein, 2028 Johannesburg (South Africa)

    2015-04-25

    Graphical abstract: The transition temperature of 350 °C for the formation of c-NiO from h-NiS oxidation was obtained from structural and optical property studies and by calculating the number of spins obtained from the EPR data. Vibrating sample magnetometry (VSM) shows that this pure NiS has both ferromagnetic ordering and paramagnetic domains. Further, the transition temperature of −9 °C of the pure α-NiS nano-alloys was confirmed by performing electrical measurements on the as-synthesized material. - Highlights: • Single hexagonal phase NiS obtained by microwave assisted hydrothermal synthesis. • NiS nanoalloys show both ferromagnetic and paramagnetic domains by VSM. • Structural evolution of annealed NiS and temperature dependent NiS oxidation presented. • Phase transition from NiS to NiO studied and correlated to the EPR spin population data and crystallite size. • Ferromagnetic and paramagnetic ordering observed for the raw NiS nanostructures. - Abstract: Single phase α-NiS nano-compounds with uniformly distributed hierarchical networks were synthesized by a microwave-assisted hydrothermal technique. The materials were evaluated for thermal stability under an oxidative environment and at temperatures between 150 °C and 600 °C. NiS materials showed stability at 300 °C and NiO formation was observed from 350 °C to 600 °C. The annealing effect on the crystalline size and IR absorption of the annealed samples is reported by XRD and FTIR studied. The EPR properties of the annealed materials were studied and compared to the oxidized materials. The transition temperature of 350 °C for the formation of NiO from NiS oxidation was confirmed by calculating the number of spins obtained from the EPR data. Vibrating sample magnetometry (VSM) shows that this pure NiS has both ferromagnetic ordering and paramagnetic domains. Further, the transition temperature of −9 °C of the pure α-NiS nano-compounds was confirmed by performing electrical

  5. Time and environmental science. Pt. 2. Time and fundamental concepts; Die Bedeutung der Zeit. T. 2. Die Umweltwissenschaften im Kontext von Zeit: Begriffe unter dem Aspekt der Zeit

    Energy Technology Data Exchange (ETDEWEB)

    Kuemmerer, K. [Inst. fuer Umweltmedizin und Krankenhaushygiene, Freiburg (Germany); Held, M. [Evangelische Akademie, Tutzing (Germany)

    1997-06-01

    Forschungsergebnisse von grundlegender Bedeutung sind wie z.B. Persistenz von Schadstoffen, Irreversibilitaet von Veraenderungen, Schaden und Schaedigung und auch Elastizitaet oder Resilience von Oekosystemen. Insbesondere Zeitskalen und Rhythmen sowie deren Vielfalt sind dafuer von Bedeutung. Hinsichtlich ihrer Persistenz besonders kritische Stoffe zeichnen sich dadurch aus, dass ihre Reaktivitaet zwar so gering ist, dass sie fuer die Anwendung stabil genug sind, die Reaktivitaet aber noch in gewissem Mass vorhanden ist und sie eine nicht zu hohe Transportrate besitzen. Persistenz ist somit ein vom Kontext abhaengiges Kriterium. Ob Aenderungen als reversibel oder irreversibel einzustufen sind, ist von den betrachteten Zeitraeumen und jeweiligen Systemen, deren Beschreibung und den hierfuer ausgewaehlten Parametern abhaengig. Voraussetzungen fuer den Fortbestand eines Systems zu schaffen, bedeutet u.a. die systemeigene Entwicklungsgeschwindigkeit und die Verschraenktheit unterschiedlicher Zeitskalen zu beachten. Wenn Stoerungen, die zu schnellen Aenderungen und somit zu kritischen Fluktuationen fuehren, vermieden werden, koennen sich oekologische Systeme entsprechend ihrer eigenen Dynamik weiterentwickeln. Die Dauer von Stoerungen sollte moeglichst kurz sein, um anthropogene, im Vergleich zur systemeigenen Zeitskala schnelle Veraenderungen von Oekosystemen zu minimieren. (orig.)

  6. The Water Reuse project: Sustainable waste water re-use technologies for irrigated land in NIS and southern European states; project overview and results.

    Science.gov (United States)

    van den Elsen, E.; Doerr, S.; Ritsema, C. J.

    2009-04-01

    In irrigated areas in the New Independent States (NIS) and southern European States, inefficient use of conventional water resources occurs through incomplete wetting of soils, which causes accelerated runoff and preferential flow, and also through excessive evaporation associated with unhindered capillary rise. Furthermore, a largely unexploited potential exists to save conventional irrigation water by supplementation with organic-rich waste water, which, if used appropriately, can also lead to improvements to soil physical properties and soil nutrient and organic matter content. This project aims to (a) reduce irrigation water losses by developing, evaluating and promoting techniques that improve the wetting properties of soils, and (b) investigate the use of organic-rich waste water as a non-conventional water resource in irrigation and, in addition, as a tool in improving soil physical properties and soil nutrient and organic matter content. Key activities include (i) identifying, for the NIS and southern European partner countries, the soil type/land use combinations, for which the above approaches are expected to be most effective and their implementation most feasible, using physical and socio-economic research methods, and (ii) examining the water saving potential, physical, biological and chemical effects on soils of the above approaches, and also their impact on performance. Expected outputs include techniques for sustainable improvements in soil wettability management as a novel approach in water saving, detailed evaluation of the prospects and effects of using supplemental organic-rich waste waters in irrigation, an advanced process-based numerical hydrological model, fully adapted to quantify and upscale resulting water savings and nutrient and potential contaminant fluxes for irrigated areas, and identification of suitable areas in the NIS and Mediterranean (in soil, land use, legislative and socio-economic terms) for implementation.

  7. Experimental study of the function of the sodium/iodide symporter (nis) in the nude mice bearing breast cancer

    International Nuclear Information System (INIS)

    Fan Wei; Wang Guohui; Zhang Weiguang; Dai Junjin; Yang Xiaochun

    2004-01-01

    Objective: To investigate the function of the sodium / iodide symporter (NIS) and the feasibility of treating breast cancer by studying the distribution and imaging of the nude mice bearing breast cancer. Methods: The animal model of MCF-7/ER(+)-bearing and MCF-7/ER(-)-bearing human breast cancer nude mice were prepared before experiments. The mice were intraperitoneally injected with 131I when tumor grown to 0.8-1 cm . The distribution of 131I in different tissues was detected at different time ( 6, 12, and 24h ). The percentage of the injected dose per gram of tissue (%D/g) and the ratio of Tumor/Non-tumor were calculated. Meanwhile, the nude mice were imaged at different time. Results: The 131I in tumor tissue in the MCF-7/ER(+)group was higher than that of MCF- 7/ER(-) group at 6h after injection, and the %ID/g were 6.13% and 2.37% respectively. The %lD/g at 12 h of two groups were 9.31 and 3.12, and were 11.21 and 3.47 at 24 h. There was a distinguish difference between them (p<0.05). At 12 h, the values of T/NT of blood, heart, lung, intestine and muscle were 2.39,3.06,3.94, 7.69 and 7.60 and were 5.15, 5.47, 5.29, 11.44 and 10.99 at 24 h. The values of T/NT of MCF-7/ER(-) group were much lower than those of MCF-7/ER(+) group. The imaging results showed that there was much radioactivity in tumor tissue in the MCF-7/ER(+) group at 12 h . The control groups has no obvious radioactivity in the tumor tissue all the time. Conclusion: Sodium/iodide symporter expressed in the estrogen-receptor-positive breast cancer tissue could transformed actively 131I into tumor tissue, which suggests 1311 therapy might become a promising way to treat breast cancer. (authors)

  8. Review: Mäder, Maya (2017: Selbsterfahrung in der Psychotherapie (Self experience in Psychotherapy, Die Bedeutung für den Kompetenzerwerb in der Aus- und Weiterbildung zum transaktionalytischen Psychotherapeuten (The significance for getting competence in training of transactional psychotherapy Münster: Waxmann

    Directory of Open Access Journals (Sweden)

    Günther Mohr

    2017-07-01

    Full Text Available Review: Mäder, Maya (2017: Selbsterfahrung in der Psychotherapie (Self experience in Psychotherapy, Die Bedeutung für den Kompetenzerwerb in der Aus- und Weiterbildung zum transaktionalytischen Psychotherapeuten (The significance for getting competence in training of transactional psychotherapy Münster: Waxmann   Citation - APA format: Mohr, G. (2017. Review: Mäder, Maya (2017: Selbsterfahrung in der Psychotherapie (Self experience in Psychotherapy, Die Bedeutung für den Kompetenzerwerb in der Aus- und Weiterbildung zum transaktionalytischen Psychotherapeuten (The significance for getting competence in training of transactional psychotherapy Münster: Waxmann. International Journal of Transactional Analysis Research & Practice, 8(2, 49-50.

  9. “GUERRA DE OLHARES”: EMULAÇÃO E AGUDEZA EM VÊNUS E ADÔNIS (1593, DE WILLIAM SHAKESPEARE

    Directory of Open Access Journals (Sweden)

    Lavinia Silvares

    2013-12-01

    Full Text Available Neste artigo, proponho investigar alguns aspectos da relação entre a emulação dos antigos e a produção da agudeza em Vênus e Adônis, de Shakespeare, publicado pela primeira vez em 1593, em Londres. Nesse poema narrativo, a emulação de uma passagem das Metamorfoses de Ovídio é explícita e marca o lugar de autoridade a partir do qual diversas técnicas retórico-poéticas de amplificação do tópico inventivo e elocutivo serão empregadas para efetuar a agudeza do poema. Assim, proponho discutir como se legitimam as novidades de matéria e estilo poético em Vênus e Adônis ao mesmo tempo em que se preservam, retoricamente, as relações de pertencimento à autoridade antiga imitada. Para esse propósito, refiro-me a um texto preceptivo da época, o Discurso comparativo, de Francis Meres, para discutir como se realiza a operação de associação dos “novos” poetas a autoridades antigas.

  10. Main results of ten years co-operation with Nis in the field of physical protection of nuclear materials and nuclear facilities

    International Nuclear Information System (INIS)

    Salewski, P.; Gutschmidt, W.

    2001-01-01

    The Federal Republic of Germany (FRG), the Russian Federation (RF) and the New Independent States (NIS) have been working closely together since 1992 in the field of physical protection. The success of this co-operative work is based on mutually beneficial agreements between corresponding FRG and RF ministries. The main working points of these agreements were a) a mutual exchange of information and experience, and b) assistance in developing licensing and regulatory procedures and guidelines, and c) physical upgrades to Russian nuclear facilities. The first two points have been established by holding seminars, workshops and by on-site instruction. Upgrades of RF nuclear installations, financed by the FRG were performed at: the Bochvar Institute in Moscow, the Kurchatov Institute in Moscow and the Mayak reactor plant in Chelyabinsk. This paper will outline the progress made to date and the GRS procedure for achieving successful co-operation with its RF and NIS counterparts. The major results of ten years cooperation will be shown. The following document describes the experiences gained during the evaluation of security reports by GRS as an external expert organisation in contract with the Supervisory Authorities. (authors)

  11. Begriffsverwirrung? Interpretation Analyse Bedeutung Applikation

    Directory of Open Access Journals (Sweden)

    Mayr, Jeremia Josef M.

    2017-11-01

    Full Text Available Empirical research on the reception of biblical texts confronts scientific exegesis with valid and challenging requests and demands. The hermeneutic question of the compatibility of interpretations resulting out of different contexts (e.g. scientific exegesis and ordinary readers‘ exegesis plays an important role. Taking these requests seriously by coherently restructuring fundamental and central aspects of the theory of scientific interpretation, the present article attempts to offer a stimulating approach for further investigation.

  12. Combination therapy and evaluation of therapeutic effect in hepatocellular carcinoma cell using triple reporter genes; containing for NIS, HSV1-sr39tk and GFP

    Energy Technology Data Exchange (ETDEWEB)

    Lee, You La; Lee, Yong Jin; Ahn, Sohn Joo; Ahn, Byeong Cheol; Lee, Sang Woo; Yoo, Jeong Soo; Lee, Jae Tae [Kyungpook National University, Daegu (Korea, Republic of)

    2007-07-01

    To identify therapeutic effect after combine Sodium Iodine Symporter (NIS) and Mutant Herpes-simplex virus type 1 sr39tk (HSV1-sr39tk) expression in hepatocellular carcinoma cell, we transfected triple gene and investigated the properties of these gene ability in hepatocellular carcinoma cell line. After making vector with gene encoding a fusion protein comprised of HSV1-sr39tk and green florescence protein (GFP), to make triple reporter genes NIS gene was further fused to the vector using IRES vector. The vector expressing triple reporter gene was transfected to the Huh-7 cell line using liposome. Functions of hNIS and HSV1-sr39tk expression were confirmed by radio iodine uptake with and without perchlorate and [3H]-penciclovir (3-H PCV) uptake, respectively. To evaluate therapeutic effect in vitro, GCV and I-131 was treated in Huh-7/NTG cell and dual therapy performed. An animal imaging acquired using Optix and microPET in vivo. I-125 uptake was increased up to 100-fold compare to that of non-transfected cells. The transfected cell accumulated H-3 PCV up to 53 times higher at 2 hour than that of non-transfected cells. With fluorescence microscopy, green fluorescence was detected in the transfected cell. In cytotoxic studies, the cell viability of Huh-7/NTG cell was decreased to 41 % of control cell at 10ug/ml GCV concentrations. The survival rate of the Huh-7/NTG cell treated with I-131 decreased up to 16%. In I-131 and GCV dual therapy, Huh-7/NTG cell survival rate decreased up to 4%. In animal studies, Huh-7/NTG tumors showed higher uptake of 18F-FHBG and I-124 than Huh-7 tumors. GFP signal is also higher in Huh-7/NTG tumor than control. We successfully constructed a vector with delivery two therapeutic genes and one reporter gene and transfected the vector to a Huh-7 cell. The hepatocellular carcinoma cell transfected with the vector can be treated with GCV and I-131. The effect of dual gene therapy could be easily assessed by the optical reporter gene imaging.

  13. Treatment with rhenium-188-perrhenate and iodine-131 of NIS-expressing mammary cancer in a mouse model remarkably inhibited tumor growth

    Energy Technology Data Exchange (ETDEWEB)

    Dadachova, Ekaterina [Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461 (United States)]. E-mail: edadacho@aecom.yu.edu; Nguyen, Andrew [Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461 (United States); Lin, Elaine Y. [Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461 (United States); Gnatovskiy, Leo [Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461 (United States); Lu, Ping [Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461 (United States); Pollard, Jeffrey W. [Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461 (United States)

    2005-10-01

    Introduction: Novel therapeutic modalities are needed for breast cancer patients in whom standard treatments are not effective. Mammary gland sodium/iodide symporter has been identified as a molecular target in breast cancers in humans and in some transgenic mouse models. We report the results of a therapy study with {sup 131}I{sup -} and {sup 188}ReO{sub 4} {sup -} of breast cancer in polyoma middle T oncoprotein (PyMT) transgenic mice endogenously expressing the Na{sup +}/I{sup -} symporter (NIS). Methods: PyMT mice (12-13 weeks old) with one palpable tumor of 0.5-0.8 cm in diameter were used. For the therapy studies, PyMT mice were (1) treated with two intraperitoneal injections of 1.5 mCi of {sup 188}ReO{sub 4} {sup -} 1 week apart, (2) pretreated for 1 week with 5 {mu}g of triiodothyronine (T3) followed by two intraperitoneal injections of 1.5 mCi of {sup 131}I{sup -} 1 week apart or (3) left untreated. The tumor and normal organ uptakes were assessed by scintigraphic imaging. The thyroid function of treated and control animals was evaluated at the completion of the study by measuring the T3/thyroxine (T4) ratio in their blood. Results: There was significant uptake of {sup 131}I{sup -} and {sup 188}ReO{sub 4} {sup -} in the primary palpable tumors as well as in nonpalpable tumors, stomachs and thyroids. The tumor uptake after the second injection was 10 times lower in comparison with the first injection. Tumor growth was significantly inhibited in both the {sup 131}I{sup -} and {sup 188}ReO{sub 4} {sup -} groups in comparison with the control group, and tumors in the {sup 188}ReO{sub 4} {sup -} group increased in size significantly less than in the {sup 131}I{sup -} group. The T3/T4 ratios were calculated to be 27 and 25 for the control group and the {sup 188}ReO{sub 4} {sup -} group, respectively; for {sup 131}I{sup -}, both the T3 and T4 levels were below detection limit, demonstrating much less effect on the thyroids of treatment with {sup 188}ReO{sub 4

  14. Treatment with rhenium-188-perrhenate and iodine-131 of NIS-expressing mammary cancer in a mouse model remarkably inhibited tumor growth

    International Nuclear Information System (INIS)

    Dadachova, Ekaterina; Nguyen, Andrew; Lin, Elaine Y.; Gnatovskiy, Leo; Lu, Ping; Pollard, Jeffrey W.

    2005-01-01

    Introduction: Novel therapeutic modalities are needed for breast cancer patients in whom standard treatments are not effective. Mammary gland sodium/iodide symporter has been identified as a molecular target in breast cancers in humans and in some transgenic mouse models. We report the results of a therapy study with 131 I - and 188 ReO 4 - of breast cancer in polyoma middle T oncoprotein (PyMT) transgenic mice endogenously expressing the Na + /I - symporter (NIS). Methods: PyMT mice (12-13 weeks old) with one palpable tumor of 0.5-0.8 cm in diameter were used. For the therapy studies, PyMT mice were (1) treated with two intraperitoneal injections of 1.5 mCi of 188 ReO 4 - 1 week apart, (2) pretreated for 1 week with 5 μg of triiodothyronine (T3) followed by two intraperitoneal injections of 1.5 mCi of 131 I - 1 week apart or (3) left untreated. The tumor and normal organ uptakes were assessed by scintigraphic imaging. The thyroid function of treated and control animals was evaluated at the completion of the study by measuring the T3/thyroxine (T4) ratio in their blood. Results: There was significant uptake of 131 I - and 188 ReO 4 - in the primary palpable tumors as well as in nonpalpable tumors, stomachs and thyroids. The tumor uptake after the second injection was 10 times lower in comparison with the first injection. Tumor growth was significantly inhibited in both the 131 I - and 188 ReO 4 - groups in comparison with the control group, and tumors in the 188 ReO 4 - group increased in size significantly less than in the 131 I - group. The T3/T4 ratios were calculated to be 27 and 25 for the control group and the 188 ReO 4 - group, respectively; for 131 I - , both the T3 and T4 levels were below detection limit, demonstrating much less effect on the thyroids of treatment with 188 ReO 4 - than with 131 I - . Conclusions: These results prove that NIS expression in breast tumors in animal models allows specific, efficient and safe treatment with a variety of

  15. Juan del Encina (1469-1529 und die Bedeutung des Humanismus für die spanische Musik am Ende des 15. Jahrhunderts

    Directory of Open Access Journals (Sweden)

    Zywietz, Michael

    2002-12-01

    Full Text Available In recent decades studies on humanism have stressed the significance of the humanist movement in Spain during the 15th and 16th centuries and thus countered the dictum of "cultural belatedness" or the absence of a Spanish Renaissance. According to education and activity Encina must be called a humanist; moreover he personifies an ideal by combining the functions of poet and composer. In the Cancionero Musical de Palacio Encina is clearly the dominating composer. Since the cultivation of music at the court of the catholic kings in the second half of the 15th century was comparable to that at other European courts, it is surprising that Spanish composers took up the international style, dominated by franco-flemish composers, only in a very limited way, but established a separate national tradition in the field of secular vocal music. The striking simplicity of Spanish secular polyphony has often been interpreted as a deficiency and the lack of ability to adapt the compositional techniques of franco-flemish composers, who were taken as stylistic model; whereas the Spanish music historiography of the 19th and early 20th century emphasizing national aspects endeavored to show equivalents —nonexistent in such a way— to developments in Burgundy and Italy. Taking Encinas "Levanta Pascual" as example, the response to a concrete historical event (the fall of Grenada 1492 characteristic of a specific humanist conception will be illustrated.

    [de] In den jüngst vergangenen Jahrzehnten hat dir Humanismus-Forschung die Bedeutung von der humanistischen Bewegung in Spanien im 15. und 16. Jahrhundert hervorgehoben und ist so dem Diktum der „kulturellen Verspätung" und dem Fehlen einer Renaissance in Spanien entgegengetreten. Nach Ausbildung und Tätigkeit ist Encina als Humanist zu bezeichnen, zudem verkorpert er das Idealbild der Personalunion von Dichter und Komponist. Im

  16. Mechanisms and rates of proton transfer to coordinated carboxydithioates: studies on [Ni(S2CR){PhP(CH2CH2PPh2)2}](+) (R = Me, Et, Bu(n) or Ph).

    Science.gov (United States)

    Alwaaly, Ahmed; Clegg, William; Henderson, Richard A; Probert, Michael R; Waddell, Paul G

    2015-02-21

    The complexes [Ni(S2CR)(triphos)]BPh4 (R = Me, Et, Bu(n) or Ph; triphos = PhP{CH2CH2PPh2}2) have been prepared and characterised. X-ray crystallography (for R = Et, Ph, C6H4Me-4, C6H4OMe-4 and C6H4Cl-4) shows that the geometry of the five-coordinate nickel in the cation is best described as distorted trigonal bipyramidal, containing a bidentate carboxydithioate ligand with the two sulfur atoms spanning axial and equatorial sites, the other axial site being occupied by the central phosphorus of triphos. The reactions of [Ni(S2CR)(triphos)](+) with mixtures of HCl and Cl(-) in MeCN to form equilibrium solutions containing [Ni(SH(S)CR)(triphos)](2+) have been studied using stopped-flow spectrophotometry. The kinetics show that proton transfer is slower than the diffusion-controlled limit and involves at least two coupled equilibria. The first step involves the rapid association between [Ni(S2CR)(triphos)](+) and HCl to form the hydrogen-bonded precursor, {[Ni(S2CR)(triphos)](+)HCl} (K) and this is followed by the intramolecular proton transfer (k) to produce [Ni(SH(S)CR)(triphos)](2+). In the reaction of [Ni(S2CMe)(triphos)](+) the rate law is consistent with the carboxydithioate ligand undergoing chelate ring-opening after protonation. It seems likely that chelate ring-opening occurs for all [Ni(S2CR)(triphos)](+), but only with [Ni(S2CMe)(triphos)](+) is the protonation step sufficiently fast that chelate ring-opening is rate-limiting. With all other systems, proton transfer is rate-limiting. DFT calculations indicate that protonation can occur at either sulfur atom, but only protonation at the equatorial sulfur results in chelate ring-opening. The ways in which protonation of either sulfur atom complicates the analyses and interpretation of the kinetics are discussed.

  17. EPIDEMIOLOGICAL - DEMOGRAPHIC CHARACTERISTIC OF SUICIDE ATTEMPTS IN ADOLESCENS TREATED AT THE INSTITUTE FOR MENTAL HEALTH IN NIS IN PERIOD OF 1999-2003

    Directory of Open Access Journals (Sweden)

    Ljubomir Milosavljevic

    2004-07-01

    Full Text Available The topic of this work is an epidemiological research of the suicide attempts of adolescents treated at the Institute for Mental Health Nis. The investigation comprises the period from 1999 up to 2003 year. The number of adolescents suicide attempts is increasing, and it is the highest one in 2003 year. Suicide attempt is most frequent with elderly female adolescents aged 17. A suicide attempt is preceded with manifestation in a form of mood disturbance in the scope of reactive situations. A dysfunctional family is the suicidal adolescent’s framework within which he moves while as, a means for the attempt, benzodiazepin’s group of medicaments is chosen by him.

  18. Water transport by Na+-coupled cotransporters of glucose (SGLT1) and of iodide (NIS). The dependence of substrate size studied at high resolution

    DEFF Research Database (Denmark)

    Zeuthen, Thomas; Belhage, Bo; Zeuthen, Emil

    2005-01-01

    and osmosis at the membrane with diffusion in the cytoplasm. The combination of high resolution measurements and precise modelling showed that water transport across the membrane can be explained by cotransport of water in the membrane proteins and that intracellular unstirred layers effects are minute.......The relation between substrate and water transport was studied in Na+-coupled cotransporters of glucose (SGLT1) and of iodide (NIS) expressed in Xenopus oocytes. The water transport was monitored from changes in oocyte volume at a resolution of 20 pl, more than one order of magnitude better than...... previous investigations. The rate of cotransport was monitored as the clamp current obtained from two-electrode voltage clamp. The high resolution data demonstrated a fixed ratio between the turn-over of the cotransporter and the rate of water transport. This applied to experiments in which the rate...

  19. NiS and MoS2 nanosheet co-modified graphitic C3N4 ternary heterostructure for high efficient visible light photodegradation of antibiotic.

    Science.gov (United States)

    Lu, Xuejun; Wang, Yu; Zhang, Xinyi; Xu, Guangqing; Wang, Dongmei; Lv, Jun; Zheng, Zhixiang; Wu, Yucheng

    2018-01-05

    The development of efficient solar driven catalytic system for the degradation of antibiotics has become increasingly important in environmental protection and remediation. Non-noble-metal NiS and MoS 2 nanosheet co-modified graphitic C 3 N 4 ternary heterostructure has been synthesized via a facile combination of hydrothermal and ultrasound method, and the ternary heterostructure has been utilized for photocatalytic degradation of antibiotic agents. The antibiotics of ciprofloxacin (CIP) and tetracycline hydrochloride (TC) were photodegraded by the hybrid under the visible light. The optimal photodegradation rate of the ternary heterostructure reaches about 96% after 2h irradiation, which is 2.1 times higher than that of pure g-C 3 N 4 for TC degradation. The photocatalytic degradation rates of the ternary heterostructure for both CIP and TC obey the pseudo-first-order kinetic model. The enhanced visible light adsorption and charge separation efficiency contribute to the photocatalytic performance of the ternary heterostructure. This work provides new insights and pathways by which efficient degradation of antibiotics can be achieved and will stimulate further studies in this important field. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. Allotment plan as a condition for sustainable development on the example of detailed regulation 'Stanko Vlasotinčanin' in Nis

    Directory of Open Access Journals (Sweden)

    Obradović Tanja

    2012-01-01

    Full Text Available In order to protect the environment and creation the conditions for a good and healthy life, the construction of buildings should be sustainable. It is essential that the entire process that includes planning, design and realization, be consistent with bioclimatic principles. Allotment plan should be an integral part of the planning process because it is an instrument to control the use of construction land and prevention the negative consequences that are created by uncontrolled action of the market. This paper analyzes the detailed regulation plan, 'Stanko Vlasotinčanin' in Nis with emphasis on the lack of plan allotment and (non application of bioclimatic principles in the planning. Performs a comparison with the detailed planning before 2003, ie. before the Law on planning and construction. Analyses the legislation relating to land use. Recommendations for amending the same, and the introduction of urban consolidation as a possible model of land development and implementation of spatial planning. It is concluded that it is necessary to undertake a number of different measures that are primarily related to the amendment and enforcement of legislation, the introduction of assessment of market value of land and the involvement and the willingness of experts and institutions for their implementation.

  1. Ganoderma-Like MoS2 /NiS2 with Single Platinum Atoms Doping as an Efficient and Stable Hydrogen Evolution Reaction Catalyst.

    Science.gov (United States)

    Guan, Yongxin; Feng, Yangyang; Wan, Jing; Yang, Xiaohui; Fang, Ling; Gu, Xiao; Liu, Ruirui; Huang, Zhengyong; Li, Jian; Luo, Jun; Li, Changming; Wang, Yu

    2018-05-27

    Herein, a unique ganoderma-like MoS 2 /NiS 2 hetero-nanostructure with isolated Pt atoms anchored is reported. This novel ganoderma-like heterostructure can not only efficiently disperse and confine the few-layer MoS 2 nanosheets to fully expose the edge sites of MoS 2 , and provide more opportunity to capture the Pt atoms, but also tune the electronic structure to modify the catalytic activity. Because of the favorable dispersibility and exposed large specific surface area, single Pt atoms can be easily anchored on MoS 2 nanosheets with ultrahigh loading of 1.8 at% (the highest is 1.3 at% to date). Owing to the ganoderma-like structure and platinum atoms doping, this catalyst shows Pt-like catalytic activity for the hydrogen evolution reaction with an ultralow overpotential of 34 mV and excellent durability of only 2% increase in overpotential for 72 h under the constant current density of 10 mA cm -2 . © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. The Role of Amateur Football in Circular Migration Systems in South Africa Zur Bedeutung des Amateurfußballs für zirkuläre Migrationssysteme in Südafrika

    Directory of Open Access Journals (Sweden)

    Malte Steinbrink

    2010-01-01

    Full Text Available This article explores the significance of amateur football for the changing patterns of circular migration in post-Apartheid South Africa. Even after the end of Apartheid, the abolishment of the migrant labour system has not brought a decline of circular migration. The state-institutionalised system has merely been replaced by an informal system of translocal livelihood organisation. The new system fundamentally relies on social networks and complex rural-urban linkages. Mobile ways of life have evolved that can be classified as neither rural nor urban. Looking into these informal linkages can contribute to explaining the persistence of spatial and social disparities in “New South Africa”. This paper centres on an empirical, bi-local case study that traces the genesis of the socio-spatial linkages between a village in former Transkei and an informal settlement in Cape Town. The focus is on the relevance of football for the emergence and stabilisation of translocal network structures. Der vorliegende Beitrag untersucht die Bedeutung des Amateurfußballs für zirkuläre Migrationsmuster im heutigen Südafrika. Der Umfang zirkulärer Migration hat nach dem Ende der Apartheid und der Abschaffung des Wanderarbeitssystems nicht abgenommen, vielmehr wurde das institutionalisierte staatliche System durch ein informelles System translokaler Strategien zur Existenzsicherung ersetzt. Dieses neue System basiert auf sozialen Netzwerken und komplexen Land-Stadt-Verbindungen; die so entstandene mobile Lebensweise kann weder als urban noch als ländlich charakterisiert werden. Eine Untersuchung dieser informellen Verbindungen kann dazu beitragen, die Fortdauer räumlicher und sozialer Ungleichheiten im “Neuen Südafrika” zu erklären. Im Zentrum des Beitrags steht eine bilokale Fallstudie, in der der Autor die Spuren sozialräumlicher Verbindungen zwischen einem Dorf in der früheren Transkei und einer informellen Siedlung in Kapstadt zur

  3. Public relations in risk communication: risk pr. The importance of public relations for risk communication; Public Relations in der Risikokommunikation: Risiko-PR. Die Bedeutung von Public Relations fuer die Risikokommunikation

    Energy Technology Data Exchange (ETDEWEB)

    Lehmann, K.

    2001-07-01

    Risks have become a central problem of our time, as is reflected in concepts like 'society at risk' and 'anti-technological attitude', in group protest against risks and against those who cause them, and last but not least in the critical attitude of the media. Against this background, organisations must needs enter the public discussion and be able to communicate professionally and convincingly in order to ensure their own success and further existence. The book describes the basic problems of risk research and risk communications and discusses inhowfar, and how, public relations strategies and instruments can help here. [German] Risiken werden verstaerkt zum Problem unserer Zeit. Das belegen nicht nur Begriffe wie 'Risikogesellschaft' und 'Technikfeindlichkeit', die in letzter Zeit an Bedeutung gewonnen haben, sondern auch und vor allem nachhaltige Proteste von engagierten Gruppierungen gegen Risiken und deren Verursacher oder auch die kritische Berichterstattung der Medien. Vor diesem Hintergrund ist es fuer Organisationen erforderlich, in die oeffentliche Auseinandersetzung um Risiken einzusteigen und hier professionell und ueberzeugend zu kommunizieren, um den Organisationserfolg und Organisationsbestand zu sichern. Die vorliegende Arbeit beschreibt die Grundprobleme der Risikoforschung und Risikokommunikation und diskutiert, ob und inwieweit Public Relations bei der Loesung dieser Probleme helfen koennen, da insbesondere Public Relations gezielt Strategien und Instrumente nutzen, um beispielsweise den Wissensstand der Oeffentlichkeit zu verbessern und den Dialog mit relevanten Teiloeffentlichkeiten zu foerdern. (orig.)

  4. Farmācijas doktors profesors Jānis Maizīte - viens no farmācijas muzeja veidotājiem

    Directory of Open Access Journals (Sweden)

    Inta Vegnere

    2010-12-01

    Full Text Available Pagājušajā gadā vienam no pirmās Latvijas brīvvalsts laika ievērojamākajiem farmaceitiem profesoram Jānim Maizītem apritēja 125 gadi. Profesors allaž atradies tālaika farmaceitu sabiedriskās dzīves centrā, līdzcilvēki viņu dēvējuši par Latvijas farmaceitu dvēseli. Jānis Maizīte dzimis 1883. gada 10. maijā Liepas pagasta Leču mājās kalēja ģimenē. Izglītību ieguvis Liepas pagastskolā, pēc tam mācījies privātā vidusskolā Valmierā. 1898. gadā kā eksterns nokārtojis eksāmenu Rīgas Nikolaja ģimnāzijā. Vēlēdamies iepazīties ar farmāciju, Jānis Maizīte no 1898. līdz 1901. gadam strādājis par aptiekāra mācekli Vjazmas aptiekā. 1901. gadā Tērbatas Universitātē kā eksterns nokārtojis aptiekāra palīga eksāmenu. Pēc tam līdz 1904. gadam strādājis dažādās Krievijas aptiekās (Strahovā, Astrahaņā. 1904. gadā J. Maizīte iestājies Tērbatas Universitātes Medicīnas fakultātes Farmācijas nodaļā, kuru beidzis 1908. gadā, iegūstot provizora specialitāti. Pēc tam turpat iecelts par jaunāko laborantu (asistentu, bet 1914. gadā – par vecāko asistentu. 1909. gadā. J. Maizīte nokārtojis mutiskus un rakstiskus eksāmenus farmācijas maģistra grāda iegūšanai un profesora I. Kondakova vadībā uzsācis darbu pie maģistra disertācijas "Par pinēna halogēnhidrātiem un to pārvēršanos ciklēna un santēna tipu ogļūdeņražos". Bet sākoties I Pasaules karam, Jāni Maizīti iesauca aktīvajā karadienestā par rezerves farmaceitu, tāpēc viņš šo darbu nepaguva aizstāvēt. Tikai 1924. gadā darbu par maģistra disertācijas tēmu viņš publicēja kopā ar savu skolotāju.

  5. Βιβλιοκρισία του: W. HÖRANDNER – A. RHOBY (επιμ., Die kulturhistorische Bedeutung byzantinischer Epigramme. Akten des Internationalen Workshop (Wien, 1.-2. Dezember 2006

    Directory of Open Access Journals (Sweden)

    Ιωάννης ΒΑΣΣΗΣ

    2010-05-01

    Full Text Available βιβλιοκρισία του WOLFRAM HÖRANDNER – ANDREAS RHOBY (επιμ., Die kulturhistorische Bedeutung byzantinischer Epigramme. Akten des internationalen Workshop (Wien, 1.–2. Dezember 2006, [Österreichische Akademie der Wissenschaften. Philosophisch-historische Klasse. Denkschriften, 371. Band / Veröffentlichungen zur Byzanzforschung XIV], Wien 2008, σελ. 128 + 66 πίν.(ISBN 978-3-7001-6495-1

  6. Oral vaccine of Lactococcus lactis harbouring pandemic H1N1 2009 haemagglutinin1 and nisP anchor fusion protein elevates anti-HA1 sIgA levels in mice.

    Science.gov (United States)

    Joan, Stella Siaw Xiu; Pui-Fong, Jee; Song, Adelene Ai-Lian; Chang, Li-Yen; Yusoff, Khatijah; AbuBakar, Sazaly; Rahim, Raha Abdul

    2016-05-01

    An oral lactococcal-based vaccine which haboured the haemagglutinin1 (HA1) antigen fused to nisP anchor protein for the purpose of surface displaying the HA1 antigen was developed against H1N1 virus. Recombinant L. lactis strains expressed HA1-nisP fusion proteins when induced with nisin, as confirmed through western blotting. However, immunofluorescense did not detect any surface-displayed proteins, suggesting that the protein was either unsuccessfully translocated or improperly displayed. Despite this, oral administration of recombinant L. lactis strains to BALB/c mice revealed that significant levels of anti-HA1 sIgA antibodies were detected in mice fecal suspension samples of mice group NZ9000 (pNZ:HN) when compared to the negative control NZ9000 (pNZ8048) group. Specific anti-HA1 sIgA antibodies were locally produced and live recombinant lactococcal vaccine was able to elicit humoral response of BALB/c mice despite unsuccessful surface display of the HA1 epitope.

  7. What really separates us? Survey of attitudes of young people in the cities of Kikinda (Vojvodina, Nis, Bor (South and East Serbia, and Pristina, Pec, Prizren (Kosovo

    Directory of Open Access Journals (Sweden)

    Bašić Goran

    2014-01-01

    Full Text Available The results of the survey point to a high level of agreement among youth aged between 15 and 25 years of age, high school and college students, employed and unemployed youth, men and women in the cities of Pec, Pristina, Prizren in Kosovo, and Bor, Kikinda, and Nis in Serbia, on whether the question of mutual cooperation is burdened by prejudice and events from the past, and that the possibility and the quality of cooperation is influenced by the attitudes the receive in their primary social groups such as families and peers, and also by the attitudes they receive through education and media. At the same time, the possibilities to influence the social and political change aren’t big, and the youth have no desire to take the concrete civic or political initiatives. A certain perspective in cooperation the youth see in the European constellation and the good quality education. However, youth on both sides are not open to more intensive mutual meetings - the majority would not either host peers from the other communities gladly, nor they would respond to their invitation of hosting. They are not interested in cultural values of one another, but they do think respect of human rights should be guaranteed and they are ready for toleration of differences. The necessity of youth cooperation is important for overcoming the problems that citizens of Kosovo and Serbia are facing when it comes to exercising numerous rights, which from the perspective of individual freedoms collide with the concept of state reasons and "higher" interests. The regional stability depends on overcoming the issues that governments in Serbia and Kosovo have concerning Kosovo’s status, and also from setting a network of individual and group relations among the citizens. Youth should be the carriers of social and cultural changes. In the stated attitudes there is no direct objection to such processes, but fear of changes is clearly expressed because indirectly it can be

  8. Die ambivalente Bedeutung des Urheberrechts für die Gestaltung des Internets als „Klangraum“. Eine kritische Betrachtung der urheberrechtsbezogenen Aneignung von Online-Angeboten am Beispiel Musik

    Directory of Open Access Journals (Sweden)

    Thomas Rakebrand

    2015-03-01

    Full Text Available Musik ist ein zentraler Gegenstand, mit denen sich Jugendliche und junge Erwachsene bei ihrer Identitätsbildung gezielt auseinandersetzen. Das Internet bietet ihnen dazu geeignete Strukturen, um über die Rezeption ihrer präferierten Musikinhalte hinaus kommunikativ, distributiv und produktiv-gestalterisch aktiv zu werden und sich dabei ihre Musik zu eigen zu machen. Mehr noch können die Subjekte den "Klangraum" Internet nach ihrer eigenen Facon kreieren und ihren identitätsrelevanten Sozialraum in die digitale Sphäre hinein erweitern. Doch der Aneignung von Online-Räumen sind auch Grenzen gesetzt. Insbesondere beim Thema Musik ist neben der technischen und strukturellen Rahmung der jeweiligen Online-Offerten das Urheberrecht bedeutend. Vor allem die Musikindustrie versucht seit geraumer Zeit die Interaktivität im Web 2.0 zu beschränken, respektive den Schöpfungsakt von MusikerInnen zu schützen. Es stellt sich jedoch die Frage, inwieweit dadurch auch die kreative Aneignung medialer Räume gehemmt wird. Anhand ausgewählter Untersuchungsergebnisse wird in diesem Beitrag aufgezeigt, dass die urheberrechtlichen Bestimmungen für die Gestaltung des "Klangraums" Internet eine ambivalente Bedeutung haben. Music plays a central role in young people’s identity formation. On the Internet, they find the appropriate structures to access their preferred music content as well as to communicate, distribute and productively manufacture this music to make it their own. Furthermore, the subjects of this study are able to transfer the Internet into a "sound space" of their exact preferences. By doing so, they extend their social space, which is important for their identity, into the digital area. However, the appropriation of online space is limited. Especially music does not only depend on technical und structural requirements of the online services, but also on copyright. The music industry has long tried to restrict the interactivity in Web 2

  9. [Jānis Keruss, Ineta Lipša, Inese Runce, Kaspars Zellis. Latvijas Universitātes Vēstures un filozofijas fakultātes vēsture padomju laikā: personības, struktūras, idejas (1944-1991)] / Kristine Wohlfart

    Index Scriptorium Estoniae

    Wohlfart, Kristine, 1968-

    2012-01-01

    Arvustus: Keruss, Jānis, Lipša, Ineta, Runce, Inese, Zellis, Kaspars. Latvijas Universitātes Vēstures un filozofijas fakultātes vēsture padomju laikā: personības, struktūras, idejas (1944-1991). (Riga. LU Akadēmiskais apgāds, 2010)

  10. Die Bedeutung von Lawinenabgangen fur die Schmetterlingspopulationen

    Czech Academy of Sciences Publication Activity Database

    Černý, K.; Cudlín, Pavel; Matějka, K.

    2006-01-01

    Roč. 86, - (2006), s. 5-36 ISSN 0379-0231 R&D Projects: GA MŠk OC E27.001 Institutional research plan: CEZ:AV0Z60870520 Keywords : avalanche, Lepidoptera, butterflies Subject RIV: EH - Ecology, Behaviour

  11. Freges Unterscheidung Von Sinn Und Bedeutung

    Directory of Open Access Journals (Sweden)

    Wolfgang Spohn

    2012-01-01

    Full Text Available El objetivo de este artículo es ofrecer una introducción a la filosofía del lenguaje. Esto se hará de acuerdo con la siguiente pregunta: ¿Cuál es el significado de los nombres? Así que no tengo planes para hacer frente a todas las áreas de filosofía del lenguaje, sino que deseo impartir conoci- mientos básicos, especialmente, en la distinción de Frege entre sentido y referencia. La motivación de este enfoque se funda en la consideración de que sólo un ejemplo de la teoría de los nombres puede ser el principal problema y la pregunta clave de la filosofía del lenguaje. Por lo tanto, concentrarme en este tema ofrece un recorrido teórico de carácter intro - ductorio. Por otra parte, hay pocos análisis sistemáticos de introducción sobre el desarrollo de la teoría de los nombres de los inicios de la moderna filosofía del lenguaje a los enfoques modernos y contemporáneos, falencia que este trabajo trata de responder.

  12. Grundlage und Bedeutung der operativen Endometriosetherapie

    Directory of Open Access Journals (Sweden)

    Schweppe KW

    2009-01-01

    Full Text Available Die Endometriose wird invasiv durch Laparoskopie und bioptische Sicherung diagnostiziert, sodass es nahe liegt, dass sich die chirurgische Therapie in gleicher Narkose anschließt. Unterschiedliche Wachstumsformen der Endometriose einerseits (kleinherdig-peritoneal, zystisch-ovariell oder tief infiltrierend und unterschiedliche Therapieziele andererseits (Schmerzfreiheit, Tumorbeseitigung, Schwangerschaft erfordern einen individuellen Behandlungsplan, der auch das Alter der Patientin mitberücksichtigt. Medikamentöse Therapieoptionen spielen additiv zum primär operativen Vorgehen eine Rolle, wobei oft symptomatische Maßnahmen bei dieser chronischen, rezidivierenden Krankheit ausreichen. Endoskopische Operationstechniken sind heute Standard. Unterschiede in Erfolgs- und Rezidivraten sind bisher für die verschiedenen Techniken nicht durch randomisierte Studien belegt.

  13. Die Bedeutung von Interleukon-1 beo der Entstehung der Knochenerosion

    Directory of Open Access Journals (Sweden)

    Graninger W

    2002-01-01

    Full Text Available Die chronische Polyarthritis ist eine immunmediierte entzündliche Erkrankung, die morphologisch durch eine Zerstörung der Gelenksstrukturen und des subchondralen Knochens charakterisiert ist. Obwohl schon in frühen Krankheitsstadien eine gelenksnahe Osteoporose im Nativröntgen sichtbar wird, ist die Richtigkeit der Diagnose radiologisch erst durch den Nachweis jener typischen Knochenzerstörung zu beweisen, die als Usur oder Erosion bezeichnet wird. An der Grenze zwischen dem entzündlichen Zellinfiltrat, das als Pannus makroskopisch und histologisch imponiert, und dem Gelenksknorpel (cartilage-pannus junction kommt es unter dem Einfluß aktivierter Synoviafibroblasten und ihrer Sekretionsprodukte zum Knorpelzelluntergang und zur Zerstörung der Knorpelmatrix. Gleichzeitig kommt es zur Aktivierung von Osteoklasten, die schließlich in der Entstehung der gelenksnahen Erosion und der subchondralen Knochenzysten resultiert.

  14. Die Bedeutung von Governance für das Steuerrecht

    Directory of Open Access Journals (Sweden)

    Tina Ehrke-Rabel

    2014-05-01

    Full Text Available ENGLISH: All over the world States struggle with guaranteeing effective taxation at a level playing field. The biggest tax gaps are not due to „simple“ tax fraud, but to tax evasion which in a globalized and „dematerialized“ world of economic activities taking place in the cloud is hardly detected by tax administrations. This lack of efficiency in the enforcement of tax law is not only based on the lack of State ́s resources but also on the fact that the instruments of enforcement have been adapted little to the changements in the way economic activities are effectuated. Concepts of good governance could offer new ideas for improving the enforcement rules. DEUTSCH: Eine gleichmäßige Besteuerung sicherzustellen fällt den Staaten heutzutage nicht leicht. Die größten Steuerausfälle werden nach überwiegender Auffassung nicht mehr durch einfache Steuerhinterziehungen, sondern durch Steuerumgehungen bewirkt, die in einer globalisierten und „entmaterialisierten“ (weil in der „Cloud“ stattfindenden Wirtschaftswelt vielfach vom Staat unentdeckt möglich sind. Die Vollzugsineffizienz liegt nicht nur an knappen staatlichen Ressourcen zur Sicherstellung der Kontrolle, sondern auch am Vollzugsinstrumentarium, das den geänderten Verhältnissen wirtschaftlicher Aktivitäten wenig angepasst wurde. Governance-Aspekte könnten Lösungsansätze bieten.

  15. Evaluation and development of soil values for the pathway 'soil to plant'. Significance of mercury evaporation for the burden of plants; Ueberpruefung und Fortentwicklung der Bodenwerte fuer den Boden-Pflanze-Pfad. Teilbericht 2: Evaporation von Quecksilber aus kontaminierten Boeden und deren Bedeutung fuer die Hg-Aufnahme von Kulturpflanzen

    Energy Technology Data Exchange (ETDEWEB)

    Schlueter, K; Gaeth, S

    2001-10-01

    - und Massnahmenwerten bezueglich des Einwirkungspfades Boden/Pflanze die Bedeutung der Quecksilber-Evaporation im Hinblick auf die Hg-Kontamination von Nahrungs- bzw. Futtermittelpflanzen untersucht. Zu diesem Zweck wurde ein Gefaessversuch mit drei verschiedenen Boeden und unterschiedlicher Hg-Vorbelastung (Hintergrundbelastung, geogen und anthropogen belastet) und zwei verschiedenen Pflanzenarten (Petersilie und Spinat) im Labor unter definierten Randbedingungen in geschlossenen Lysimetern durchgefuehrt. Eine wurzelbuertige Hg-Aufnahme wurde dahingehend minimiert, indem die Pflanzen in handelsueblicher Kulturerde mit geringer Hg-Konzentration isoliert wuchsen und nur der umgebende Boden Hg evaporierte. Die Hg-Konzentrationen der Pflanzen betrugen auf der unbelasteten Variante (0,1 mg Hg/kg TS Boden) 0,15 (Spinat) mg/kg TS. Bei dem anthropogen belasteten Boden (111 mg Hg/kg TS Boden) wurden Werte von 2,0 und 2,6 mg/kg TS in der Pflanze gemessen. Eine vergleichbare Groessenordnung wurde auf der geogen belasteten Variante (34 mg Hg/kg TS Boden) mit 2,1 mg/kg TS (Spinat) und 0,44 mg/kg TS (Petersilie) erreicht. Versuche mit radioaktivem {sup 203}Hg zeigten, dass Teile des evaporierten Hg-Tracers in der Blattmasse, im Stengel und selbst in der Wurzel nachgewiesen werden konnte, was auf eine Translokation innerhalb der Pflanzen vom Blatt zur Wurzel schliessen laesst. Fuer den Vergleich der Untersuchungsergebnisse mit bestehenden Literaturdaten wurde im Rahmen einer Literaturstudie der aktuelle Kenntnisstand zur Hg-Evaporation des Bodens und zur Hg-Aufnahme von Pflanzen zusammengetragen. Der Vergleich zeigt, dass die gefundenen Hg-Konzentrationen mit Ergebnissen anderer Autoren im Einklang stehen. (orig.)

  16. Evaluation and development of soil values for the pathway 'soil to plant'. Significance of mercury evaporation for the burden of plants; Ueberpruefung und Fortentwicklung der Bodenwerte fuer den Boden-Pflanze-Pfad. Teilbericht 2: Evaporation von Quecksilber aus kontaminierten Boeden und deren Bedeutung fuer die Hg-Aufnahme von Kulturpflanzen

    Energy Technology Data Exchange (ETDEWEB)

    Schlueter, K.; Gaeth, S.

    2001-10-01

    Ableitung von Pruef- und Massnahmenwerten bezueglich des Einwirkungspfades Boden/Pflanze die Bedeutung der Quecksilber-Evaporation im Hinblick auf die Hg-Kontamination von Nahrungs- bzw. Futtermittelpflanzen untersucht. Zu diesem Zweck wurde ein Gefaessversuch mit drei verschiedenen Boeden und unterschiedlicher Hg-Vorbelastung (Hintergrundbelastung, geogen und anthropogen belastet) und zwei verschiedenen Pflanzenarten (Petersilie und Spinat) im Labor unter definierten Randbedingungen in geschlossenen Lysimetern durchgefuehrt. Eine wurzelbuertige Hg-Aufnahme wurde dahingehend minimiert, indem die Pflanzen in handelsueblicher Kulturerde mit geringer Hg-Konzentration isoliert wuchsen und nur der umgebende Boden Hg evaporierte. Die Hg-Konzentrationen der Pflanzen betrugen auf der unbelasteten Variante (0,1 mg Hg/kg TS Boden) 0,15 (Spinat) mg/kg TS. Bei dem anthropogen belasteten Boden (111 mg Hg/kg TS Boden) wurden Werte von 2,0 und 2,6 mg/kg TS in der Pflanze gemessen. Eine vergleichbare Groessenordnung wurde auf der geogen belasteten Variante (34 mg Hg/kg TS Boden) mit 2,1 mg/kg TS (Spinat) und 0,44 mg/kg TS (Petersilie) erreicht. Versuche mit radioaktivem {sup 203}Hg zeigten, dass Teile des evaporierten Hg-Tracers in der Blattmasse, im Stengel und selbst in der Wurzel nachgewiesen werden konnte, was auf eine Translokation innerhalb der Pflanzen vom Blatt zur Wurzel schliessen laesst. Fuer den Vergleich der Untersuchungsergebnisse mit bestehenden Literaturdaten wurde im Rahmen einer Literaturstudie der aktuelle Kenntnisstand zur Hg-Evaporation des Bodens und zur Hg-Aufnahme von Pflanzen zusammengetragen. Der Vergleich zeigt, dass die gefundenen Hg-Konzentrationen mit Ergebnissen anderer Autoren im Einklang stehen. (orig.)

  17. Challenges/issues of NIS used in particle accelerator facilities

    Science.gov (United States)

    Faircloth, Dan

    2013-09-01

    High current, high duty cycle negative ion sources are an essential component of many high power particle accelerators. This talk gives an overview of the state-of-the-art sources used around the world. Volume, surface and charge exchange negative ion production processes are detailed. Cesiated magnetron and Penning surface plasma sources are discussed along with surface converter sources. Multicusp volume sources with filament and LaB6 cathodes are described before moving onto RF inductively coupled volume sources with internal and external antennas. The major challenges facing accelerator facilities are detailed. Beam current, source lifetime and reliability are the most pressing. The pros and cons of each source technology is discussed along with their development programs. The uncertainties and unknowns common to these sources are discussed. The dynamics of cesium surface coverage and the causes of source variability are still unknown. Minimizing beam emittance is essential to maximizing the transport of high current beams; space charge effects are very important. The basic physics of negative ion production is still not well understood, theoretical and experimental programs continue to improve this, but there are still many mysteries to be solved.

  18. Cloning of nis gene and Nisin purification from Lactococcus lactis ...

    African Journals Online (AJOL)

    user

    2014-12-31

    Dec 31, 2014 ... dimension structure of the purified Nisin was studied by CPHModels as pdb with chimera program. Key words: ..... tionists the classification of microorganisms, and makes ... towards lipid membrane (Breukink and Kruijff, 1999;.

  19. NIS tunnel junction as an x-ray photon sensor

    Science.gov (United States)

    Azgui, Fatma; Mears, Carl A.; Labov, Simon E.; Frank, Matthias A.; Sadoulet, Bernard; Brunet, E.; Hiller, Lawrence J.; Lindeman, Mark A.; Netel, Harrie

    1995-09-01

    This work presents the first results of our development of normal-insulating-superconducting tunnel junctions used as energy dispersive detectors for low energy particles. The device described here is a Ag/Al(subscript 2)O(subscript 3)/Al tunnel junction of area 1.5 multiplied by 10(superscript 4) micrometer squared with thicknesses of 200 nm for the normal Ag strip and 100 nm for the superconducting Al film. Two different high-speed SQUID systems manufactured by quantum magnetics and HYPRES, respectively, were used for the readout of this device. At 80 mK bath temperature we obtained an energy resolution DeltaE(subscript FWHM) equals 250 eV for 5.89 keV x rays absorbed directly in the normal metal. This energy resolution appears to be limited in large part by the observed strong position dependence of the device response.

  20. Network and Information Sciences (NIS) International Technology Alliance (ITA)

    Science.gov (United States)

    2016-05-01

    proposals were then assessed and a set of projects selected to create a Biennial Program Plan ( BPP ), which was then implemented and continuously...process of developing a BPP that exhibited an interdisciplinary, cross-sector culture and programme of sufficient mass. Military relevance was...to demonstrate how they had been successful in delivering the required impact in previous BPP cycles. Proposed projects were selected using these

  1. Nuclear legislation in Central and Eastern Europe and the NIS

    CERN Document Server

    2000-01-01

    This publication examines the legislation and regulations governing the peaceful uses of nuclear energy in eastern European countries. It covers 11 countries from Central and Eastern Europe and 11 countries from the New Independent States. The chapters follow a systematic format making it easier for the reader to carry out research and compare information. This study will be updated regularly. Albania Kazakhstan Armenia Latvia Belarus Lithuania Bosnia and Herzegovina Poland Bulgaria Republic of Moldova Croatia Romania Czech Republic Russian Federation Estonia Slovak Republic Former Yugoslav Re

  2. Verbitterte Frauen bewegen verletzte Männer. Wie aus Verben mit physischer Bedeutung Verben mit psychischer (Neben-)Bedeutung werden / Anni Silk

    Index Scriptorium Estoniae

    Silk, Anni

    2008-01-01

    Võrdlevalt analüüsitakse Lakoff/Johnsoni kognitivistliku metafooriteooria alusel selliseid eesti ja saksa verbe, mille esialgne tähendus seostub füüsilise maailmaga, kuid mida ülekantud tähenduses kasutatakse emotsiooniverbina

  3. Importance of diffusion imaging in liver metastases; Bedeutung der Diffusionsbildgebung bei Lebermetastasen

    Energy Technology Data Exchange (ETDEWEB)

    Riffel, P.; Schoenberg, S.O.; Krammer, J. [Medizinische Fakultaet Mannheim der Universitaet Heidelberg, Institut fuer Klinische Radiologie und Nuklearmedizin, Universitaetsmedizin Mannheim, Mannheim (Germany)

    2017-05-15

    Detection and characterization of focal liver lesions. Due to its excellent soft tissue contrast, the availability of liver-specific contrast agents and the possibility of functional imaging, magnetic resonance imaging (MRI) is the method of choice for the evaluation of focal liver lesions. Diffusion-weighted imaging (DWI) enables generation of functional information about the microstructure of a tissue besides morphological information. In the detection of focal liver lesions DWI shows a better detection rate compared to T2w sequences and a slightly poorer detection rate compared to dynamic T1w sequences. In principle, using DWI it is possible to distinguish malignant from benign liver lesions and also to detect a therapy response at an early stage. For both detection and characterization of focal liver lesions, DWI represents a promising alternative to the morphological sequences; however, a more detailed characterization with the use of further sequences should be carried out particularly for the characterization of solid benign lesions. For the assessment and prognosis of therapy response, DWI offers advantages compared to morphological sequences. For the detection of focal liver lesions DWI is in principle sufficient. After visual detection of a solid liver lesion a more detailed characterization should be carried out using further sequences (in particular dynamic T1w sequences). The DWI procedure should be used for the assessment and prognosis of a therapy response. (orig.) [German] Detektion und Charakterisierung fokaler Leberlaesionen. Die MRT ist aufgrund des exzellenten Weichteilkontrasts, der Verfuegbarkeit leberspezifischer Kontrastmittel und der Moeglichkeit funktioneller Bildgebung die Methode der Wahl zur Abklaerung fokaler Leberlaesionen. Die diffusionsgewichtete Bildgebung (''diffusion-weighted imaging'', DWI) ermoeglicht es, neben den rein morphologischen auch funktionelle Informationen ueber die Mikrostruktur eines Gewebes zu generieren. Bei der Detektion fokaler Leberlaesionen zeigt die DWI eine bessere Detektionsrate im Vergleich zu T2w-Sequenzen und eine etwas schlechtere Detektionsrate im Vergleich zu dynamischen T1w-Sequenzen. Prinzipiell ist es mit der DWI moeglich, maligne Leberlaesionen von benignen zu unterscheiden sowie ein Therapieansprechen fruehzeitig zu detektieren. Sowohl fuer die Detektion als auch fuer die Charakterisierung fokaler Leberlaesionen stellt die DWI eine vielversprechende Alternative zu den morphologischen Sequenzen dar. Insbesondere fuer die Charakterisierung solider benigner Laesionen sollte jedoch deren naehere Charakterisierung unter Zuhilfenahme weiterer Sequenzen erfolgen. Fuer die Beurteilung und die Prognose eines Therapieansprechens bietet die DWI Vorteile im Vergleich zu den rein morphologischen Sequenzen. Zur reinen Detektion fokaler Leberlaesionen ist die DWI prinzipiell ausreichend. Nach visueller Detektion einer soliden Leberlaesion sollte deren naehere Charakterisierung unter Zuhilfenahme weiterer Sequenzen (insbesondere dynamischer T1w-Sequenzen) erfolgen. Fuer die Beurteilung und die Prognose eines Therapieansprechens sollte die DWI herangezogen werden. (orig.)

  4. Zur Bedeutung von Michel Foucault für die heutige Psychiatrie

    NARCIS (Netherlands)

    Vandermeersch, P.M.G.P.

    1997-01-01

    M. Foucault´s book on the history of madness has mostly been received as an anti-psychiatric critique of the great confinement. Thus, the original meaning of the book has been discarded: a critique of the psychiatric practice from the point a view of history of science and philosophy of culture.

  5. Wirbelsäulenchirurgische Verfahren und Bedeutung bei osteoporotischen Wirbelkörperfrakturen

    Directory of Open Access Journals (Sweden)

    Teuscher R

    2013-01-01

    Full Text Available Osteoporotische Wirbelbrüche sind häufig. Der Großteil ist gutartig mit einem selbstlimitierenden Verlauf. Allerdings sehen wir in der Wirbelsäulenchirurgie zunehmend auch die Problemfälle: persistierende Instabilität/ Pseudarthrose nach einer Fraktur, der langsam progressive Verlust der Haltung/Wirbelsäulenbalance als Folge mehrerer Wirbelbrüche und schließlich neurologische Komplikationen in Verbindung mit einer osteoporotischen Fraktur. Die Injektion von Knochenzement zur Stabilisierung von Wirbelfrakturen ist effizient und hat sich bewährt. Damit erreicht man eine Stabilisierung des Wirbels und eine sehr wirksame Schmerzkontrolle. Zusätzlich (und häufig zu wenig beachtet können damit ein weiteres Einsintern des Knochens verhindert und Folgekomplikationen so vermieden werden. Wo diese einfache minimalinvasive Technik nicht mehr genügt, sind offene Verfahren notwendig. Auch dabei wird eine kombinierte Technik angewendet: Die Stabilisierung erfolgt nach den gängigen wirbelsäulenchirurgischen Prinzipien, zur Verankerung der Implantate im osteoporotischen Knochen wird ebenfalls Knochenzement verwendet.

  6. Die Bedeutung der aktuellen Nierentumorklassifikation für Diagnostik und Therapie

    Directory of Open Access Journals (Sweden)

    Moch H

    2008-01-01

    Full Text Available In den letzten Jahren erweiterte sich das Verständnis zur Histogenese von Nierentumoren durch neue molekulare Erkenntnisse erheblich. Damit wurde es möglich, eine Klassifikation der Nierentumoren auf der Basis von molekularen Veränderungen vorzunehmen. Daneben wurden neue Tumortypen identifiziert, deren Kenntnis erheblichen Einfluss auf die Auswahl der Behandlungsstrategien haben kann. Bei zystischen Nierentumoren gibt es zum Beispiel neben Tumoren mit sehr guter Prognose auch hochmaligne Tumoren. Die charakteristischen molekularen Veränderungen sind einerseits für die Klassifikation der verschiedenen Nierentumoren relevant, andererseits können sie auch innerhalb der klarzelligen Nierenzellkarzinome ein potenzielles Ansprechen auf neue Medikamente vorhersagen. Die Kenntnis der molekularen Zielstrukturen bei Nierenkarzinomen ist die Grundlage für neue Therapien, die gegen spezifische Strukturen gerichtet sind. HIF- α-responsive Gene, z. B. VEGF, PDGF, TGFα, EGFR und Ca IX spielen dabei eine zentrale Rolle beim klarzelligen Nierenkarzinom.

  7. Swimming pool hydraulics and their significance for public pools. Bedeutung der Beckenhydraulik in oeffentlichen Schwimmbaedern

    Energy Technology Data Exchange (ETDEWEB)

    Gansloser, G

    1989-11-01

    The term of swimming pool hydraulics means the process of letting in and drawing off water to and from the pool while ensuring that no inadmissible water-borne contaminant concentrations will occur anywhere within the pool. Measurements were performed on a pool to study the significance of correct pool hydraulics. The author points out that a wrong water recirculation design will bring to nought the effects of an elaborate water treatment system; by contrast, poor pool water quality can be greatly improved by redesigning the pool water hydraulics approach. In principle, systems with with water inlet at one side and water outlet at the far side will fall short of hygienic requirements. (BWI).

  8. Die Bedeutung der Sukzession in den Schlagfluren für die Waldentwicklung des Jeschkenkammes (Tschechien)

    Czech Academy of Sciences Publication Activity Database

    Petřík, Petr

    2014-01-01

    Roč. 2014, č. 9 (2014), s. 69-79 ISSN 1618-1735 R&D Projects: GA ČR(CZ) GA14-22658S Institutional support: RVO:67985939 Keywords : clearing communities * dynamics * monitoring Subject RIV: EF - Botanics

  9. Die Bedeutung der Koedukation fur die Genese der Studienfachwahl = The Impact of Coeducation on Vocational Choice.

    Science.gov (United States)

    Giesen, Heinz; And Others

    1992-01-01

    Presents study results of the impact of coeducational and gender segregated instruction on German students' vocational choice. Reports that students in coeducational settings tend to conform with gender typical roles in choice of majors, interests, grades, and self-assessment. Concludes that female students attending girls' schools more often go…

  10. SPECT in psychiatry; Die Bedeutung der Hirn-SPECT in der Psychiatrie

    Energy Technology Data Exchange (ETDEWEB)

    Kasper, S [Universitaetsklinik fuer Psychiatrie, Wien (Austria); Gruenwald, F [Bonn Univ. (Germany). Klinik fuer Nuklearmedizin; Danos, P [Psychiatrische Universitaetsklinik, Bonn (Germany); Walter, H [Universitaetsklinik fuer Psychiatrie, Wien (Austria); Klemm, E [Bonn Univ. (Germany). Klinik fuer Nuklearmedizin; Bruecke, T [Universitaetsklinik fuer Neurologie, Wien (Austria); Podreka, I [Universitaetsklinik fuer Neurologie, Wien (Austria); Biersack, H J [Bonn Univ. (Germany). Klinik fuer Nuklearmedizin

    1994-10-01

    In the last fifteen years different attempts have been undertaken to understand the biological basis of major psychiatric disorders. One important tool to determine patterns of brain dysfunction is single emission computed tomography (SPECT). Whereas SPECT investigations are already a valuable diagnostic instrument for the diagnosis of dementia of the Alzheimer Type (DAT) there have not been consistent findings that can be referred to as specific for any other particular psychiatric diagnostic entity. Nevertheless, SPECT studies have been able to demonstrate evidence of brain dysfunction in patients with schizophrenia, depression, anxiety disorders, and substance abuse in which other methods showed no clear abnormality of brain function. Our manuscript reviews the data which are currently available in the literature and stresses the need for further studies, especially for prediction and monitoring psychiatric treatment modalities. (orig.) [Deutsch] In den vergangenen 15 Jahren wurde durch verschiedene methodologische Ansaetze versucht, die biologischen Ursachen psychiatrischer Erkrankungen naeher zu erforschen. Als eine bedeutende Methode hat sich dabei die Single-Photonen-Emissions-Computertomographie (SPECT) herausgestellt. Waehrend die SPECT-Untersuchungen bereits Eingang in die Routinediagnostik bei Demenzen vom Alzheimer-Typ gefunden haben, konnten fuer weitere psychiatrische Erkrankungen noch keine eindeutigen Befunde etabliert werden. Mit der SPECT-Methode ist es jedoch gelungen, funktionelle Veraenderungen des Gehirns von psychiatrischen Erkrankungen darzustellen, wie z.B. Schizophrenie, Depression, Angsterkrankungen bzw. Substanzmissbrauch. In Forschungsprotokollen wird durch die SPECT-Methode versucht, abzuklaeren, inwieweit es moeglich ist, innerhalb der Erkrankungsentitaeten psychiatrischer Erkrankungen oder auch diese uebergreifend eine Subklassifizierung zu finden und evtl. Gehirnsysteme ausfindig zu machen, die mit einer spezifischen Psychopathologie verbunden sind. In dem vorliegenden Manuskript wird die Datenlage zu den SPECT-Veraenderungen bei psychiatrischen Krankheiten zusammengestellt und betont, dass weitere Studien, insbesondere zur Praediktion und Verlaufsbeurteilung psychiatrischer Erkrankungen, notwendig sind. (orig.)

  11. Identifikationsmerkmal Automobil bzw. Identifikation und Nutzen. Die theoretisch-emotionale Bedeutung des Autos

    Directory of Open Access Journals (Sweden)

    Pelters, Sarah

    2009-06-01

    Full Text Available The time when a car was used for the purpose of transportation only has probably never been. After its invention when such a machine was still hard to handle the thoughts about cars quickly moved from dangerous devils that should never be used to objects of freedom, safety and speed. They expressed wealth, status and independence and people started not only to want a car but soon enough also to differentiate between brands, models and styling. Now the question is not only how the car influenced modern life but also what the car - including its meaning and general understanding which it developed over the past - made of people. How much does a person identify with the own car, which is far more than just property?

  12. The importance of secondary radiation at radiation protection clothing; Die Bedeutung der Sekundaerstrahlung bei Strahlenschutzkleidung

    Energy Technology Data Exchange (ETDEWEB)

    Eder, Heinrich

    2017-07-01

    For a long time, the protective material lead was seen as ''gold standard'' for the shielding of photon radiation (X-ray and γ-rays). At long sight, however, lead should be eliminated from medical products. When irradiated, substitutes of lead can produce much more secondary radiation. Moreover, the radiobiological impact of the low energetic secondary radiation has to be rated higher than that of primary radiation. With the introduction of the new measuring standard IEC 6133-1 secondary radiation now is considered when evaluating attenuation properties of protective clothing.

  13. Empathische Wahrnehmung des kulturell Fremden: neun Konstruktionsmuster und deren Bedeutung für interkulturelle Bildungsprozesse

    OpenAIRE

    Riegger, Manfred

    2013-01-01

    Konstruktionsprozesse beruhen grundsätzlich auf vier Faktoren: erstens die standortge-bundene Zuschreibung des Subjekts (eigen / fremd), zweitens die korrespondierenden Emotionen (sowohl positive wie Neugier, Faszination usw. als auch Angst, Hass usw.), drittens die sinnliche Wahrnehmung von Phänomenen, welche den Subjekten präsentiert werden und viertens die subjektiven Konstruktionen in Form von neun Konstruktionsmustern, welche eine spezifische Mischung von eigen und fremd mit unterschiedl...

  14. Gesichtslose Cliquen? : Die Bedeutung von Interaktionsform, Geschlecht und Motivation in Onlinespielen

    OpenAIRE

    Meißner, Malte

    2009-01-01

    In der vorliegenden Studie werden drei Arten von Onlinespielen anhand ihrer Interaktionsformen unterschieden: MMORPGs, E-Sports und Browserspiele. Hierzu wurden Datensätze von 4330 Spielern erhoben. Acht Faktoren konnten ermittelt werden, die für Onlinespieler im Spiel und im Umgang miteinander bedeutsam sind: Wettkampf, Freundschaft, Isolation, Glamour, Gewalterleben, Gemeinschaft, Anregung und Privatheit. Einige dieser Faktoren scheinen Einfluss darauf zu nehmen, wie lange Onlin...

  15. Significance and basic patterns of risk communication; Bedeutung und Grundzuege der Risikokommunikation

    Energy Technology Data Exchange (ETDEWEB)

    Obermeier, O.P. [Gerling Akademie fuer Risikoforschung AG, Muenchen (Germany)]|[Gerling Akademie fuer Risikoforschung AG, Zurich (Switzerland)]|[Augsburg Univ. (Germany)

    1996-11-01

    The philosophically coloured paper on the aspects of risk communication patterns in society shows that debates about risks are governed by a number of stereotype characters representing the individualist and manager type, bureaucracy and law-and-order type, ego-centered embarrassment activist, and fundamentalist. Every risk-relevant group in the study tries to push forward its own interests. Risk communication is understood as a process of social dealing. (HP) [Deutsch] Die nahezu philosophischen Ueberlegungen zum Thema Risiko belegen, dass alle Risikodiskussionen von den Besitzindividualisten, Buerokraten, Betroffenheitsaktivisten und Fundamentalisten dominiert werden. Jede risikorelevante Gruppierung versucht ihre Gruppenegoismen durchzusetzen. Risikokommunikation wird als Prozess des sozialen Aushandelns aufgefasst. (HP)

  16. Ist die Gesangskomplexita¨t der Amsel in einem intrasexuellen Kontext von Bedeutung?

    DEFF Research Database (Denmark)

    Hesler, Nana; Sacher, T.; Coppack, T.

    Vogelgesang wird fu¨r ein sexuell selektiertes Merkmal gehalten, das sowohl im inter- als auch im intrasexuellen Kontext eine Rolle spielt. Dabei nimmt man an, dass der Grad der Gesangskomplexita¨t ein ehrliches Signal fu¨r die Qualita¨t des Sa¨ngers darstellt. Bei Arten, die u¨ber ein gewisses...... Repertoire verschiedener Gesangsmuster verfu¨gen (z.B. verschiedener Strophentypen), stellt die Repertoiregro¨ße ein mo¨gliches Maß der Gesangskomplexita¨t dar. Die Amsel Turdus merula verfu¨gt u¨ber ein großes gesangliches Repertoire mit komplexem Aufbau ohne festgelegte Strophentypen. Dieses Repertoire...

  17. Konzept Gender Thesaurus. Zur Bedeutung einer gemeinsamen Dokumentationssprache für Forschung und Informationseinrichtungen

    Directory of Open Access Journals (Sweden)

    Jasmin Schenk

    2016-09-01

    Full Text Available Angesichts aktueller und voraussichtlich in naher Zukunft startender Infrastrukturprojekte der Frauen/Gender-Informationseinrichtungen einerseits und der Gender Studies andererseits, soll im Folgenden auf den Sinn und die Notwendigkeit einer gemeinsamen gendersensiblen Dokumentationssprache hingewiesen werden. Dieser Beitrag entstand im Rahmen des Masterstudiums der Bibliotheks- und Informationswissenschaften (MALIS an der Technischen Hochschule Köln und verfolgt das Ziel, Vorschläge für die Erarbeitung eines Gender Thesaurus zu entwickeln.

  18. “sacherklärungen” in biblischen texten – vorkommen und bedeutung ...

    African Journals Online (AJOL)

    Konzepten von Andrea Frank (University of South Africa, Pretoria 2008), auf die .... water', or better 'many waters', there, for in this locality there are seven springs .... der Begegnung Jesu mit einer samaritanischen Frau am Brunnen in Sychar.

  19. "Krokodile hoffen nicht. Menschen hoffen.". Bedeutung und Wert des Hoffens in der menschlichen Lebensform

    OpenAIRE

    Schmitz, Barbara

    2017-01-01

    Hope is a neglected topic in philosophy. This article tries to show that hope belongs to the human form of life. We start with Wittgenstein's remark that human beings hope, while crocodiles cannot and explore the nature of hoping via three different routes: Firstly, we discuss the question whether hope is an emotion or a more or less rational attitude. Secondly, we put forward five characteristics of hope: the possibility of that which is hoped for, the temporality of the object of hope, the ...

  20. Importance of hydropower for the global power generation; Bedeutung der Wasserkraft fuer die weltweite Stromerzeugung

    Energy Technology Data Exchange (ETDEWEB)

    Schiffer, Hans-Wilhelm [World Energy Council, London (United Kingdom). World Energy Resources; RWE AG, Essen (Germany)

    2015-10-15

    The renewable energy sources have in the last ten years - not only in Germany, but also worldwide - can post disproportionately strong growth rates. This is especially true in the electricity production. Especially the new renewable energies have a stable, strong growth and gain as compared to the conventional generation ever more ground. Nevertheless, hydropower remains by far the most important source of renewable energy in electricity generation. An analysis shows that hydropower can make significant contributions to sustainable and climate-friendly energy supply by 2050, if it is possible to raise their still unused potential. [German] Die erneuerbaren Energien haben in den letzten zehn Jahren - nicht nur in Deutschland, sondern auch weltweit - ueberproportional starke Zuwachsraten verbuchen koennen. Dies gilt insbesondere in der Stromerzeugung. Gerade die neuen erneuerbaren Energien weisen ein bestaendiges, starkes Wachstum auf und gewinnen so gegenueber der konventionellen Erzeugung immer weiter an Boden. Trotzdem ist die Wasserkraft unveraendert die mit Abstand bedeutendste erneuerbare Energiequelle in der Stromerzeugung. Eine Analyse zeigt, dass die Wasserkraft bis 2050 signifikante Beitraege zu einer nachhaltigen und klimaschonenden Energieversorgung leisten kann, wenn es gelingt, ihre noch ungenutzen Potenziale zu heben.

  1. Processes, spheres of use and importance of sewage sludge disintegration; Verfahren, Einsatzgebiete und Bedeutung der Klaerschlammdesintegration

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, J. [Technische Univ. Braunschweig (Germany). Inst. fuer Siedlungswasserwirtschaft; Technische Univ. Braunschweig (Germany). Inst. fuer Mechanische Verfahrenstechnik

    1999-07-01

    The paper gives an overview of results attained by means of mechanical sludge disintegration methods and compares them with thermal and ozone treatment. The objective is to describe in scientific as well as application-oriented terms the opportunities held and limits to this process step of sludge treatment. (orig.) [German] Im Rahmen des Beitrags wird eine Uebersicht ueber die mit mechanischen Verfahren der Schlammdesintegration erreichten Ergebnisse und ein Vergleich mit der Waerme- und der Ozonbehandlung gegeben. Ziel des Beitrages ist es, die Moeglichkeiten und Grenzen dieses Prozessschrittes der Schlammbehandlung aus wissenschaftlicher wie aus anwendungsorientierter Sicht darzustellen. (orig.)

  2. Die Bedeutung des Themas „Bahn“ für eine ökologische Nachhaltigskeitsbildung

    Directory of Open Access Journals (Sweden)

    Tim Engartner

    2009-08-01

    Full Text Available Die seit mehr als einem Jahrzehnt geführte Debatte über die Zukunft der Deutschen Bahn AG zeigt, dass das Themenfeld „Bahn“ zahlreiche Anknüpfungspunkte bietet, um verschiedene ökonomische Fragestellungen zu beleuchten – gerade auch im Kontext der ökologischen Nachhaltigkeitsbildung. Mit einer didaktisch und methodisch durchdachten Annäherung an das Themenfeld „Bahn“ kann dem gut begründeten, aber häufig unzureichend umgesetzten Postulat, Wissenschafts- und Schülerorientierung miteinander zu verbinden, Rechnung getragen werden. Denn die immense Bandbreite an Zugangs-, Erklärungs- und Interpretationsebenen erlaubt es nicht nur, das Umweltbewusstsein von Schüler(innen zu schärfen. Werden Anleitungen zum Fahrscheinkauf erstellt, Statistiken zu Verkehrsmarktanteilen ausgewertet und Schaubilder zu externen Verkehrskosten erörtert, können Kinder und Jugendliche auch motiviert werden, die Bahn als Transportmittel ihrer Wahl zu entdecken und somit einen nachhaltigen Beitrag zum Umwelt- und Klimaschutz zu leisten.More than a decade of debate about the future of Germany’s state-run rail company, Deutsche Bahn AG, has shown that the subject of “the railways” provides ample opportunity to discuss a whole range of economic issues, especially in the context of ecological sustainability. The desirable but often inadequately implemented goal of making science accessible to school students can be achieved through a didactically and methodologically well-planned approach, heightening students’ environmental awareness through the immense spectrum of perspectives, explanations and interpretations. And if instructions for buying tickets are prepared, statistics on transport market share analysed and graphics on the external costs of transport explored, children and young people can also be motivated to discover the railways as their preferred means of transport – a lasting contribution to environmental and climate protection.

  3. Relevance of HVDC for electrical power supply; Bedeutung der HGUein der Energieversorgung

    Energy Technology Data Exchange (ETDEWEB)

    Gambach, Herbert; Dorn, Joerg [Siemens AG, Erlangen (Germany). Power Transmission Solutions

    2012-07-01

    The finite availability of fossil energy, the turning away of many countries from nuclear power generation and the need for a limitation of CO{sub 2} emissions influence the future generation and transmission of electrical power in a significant way. In the long term these requirements can be met only by renewable energy sources, for instance solar power and wind. Another aspect is that power generation facilities are in many cases far-off from the load centers. This enforces reliable transmission systems with low losses over long distances. The high voltage direct current (HVDC) transmission complies with these demands in a beneficial way. This paper gives a short overview of the state-of-the-art and describes current developments. (orig.)

  4. Die Bedeutung internationaler Erfahrungen für den Karriereerfolg von Führungskräften

    OpenAIRE

    Biemann, Torsten

    2009-01-01

    Die langfristigen Auswirkungen internationaler Einsätze von Führungskräften auf deren Karrieren sind bislang kaum empirisch untersucht worden und die wenigen vorliegenden Ergebnisse sind widersprüchlich. Ziel dieser Studie ist deshalb die empirische Untersuchung der Auswirkungen internationaler Erfahrungen auf den Karriereerfolg von Führungskräften anhand eines Vergleichs von Führungskräften mit und ohne internationale Erfahrungen. Es zeigt sich, dass internationale Erfahrungen zu einem höher...

  5. Die Tischglocke Rudolfs II: über ihren Urheber und ihre Bedeutung

    Czech Academy of Sciences Publication Activity Database

    Bukovinská, Beket; Purš, Ivo

    -, č. 10 (2010), s. 89-104 ISSN 1213-5372 Institutional research plan: CEZ:AV0Z80330511 Keywords : Rudolphinian art * Rudolf II * magic * hermetic philosophy Subject RIV: AL - Art, Architecture, Cultural Heritage

  6. Nuclear medicine. Clinical value of the medicine methods. Nuklearmedizin. Klinische Bedeutung nuklearmedizinischer Diagnostik und Therapie

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, H A.E. [Evangelisches Krankenhaus Bethesda Gemeinnuetzige G.m.b.H., Duisburg (Germany, F.R.). Nuklearmedizinische Klinik und Poliklinik; Ortiz Berrocal, J [Universidad Autonoma de Madrid (Spain). Dept. of Nuclear Medicine; eds.

    1979-01-01

    This proceedings volume of the 16th International Annual Meeting of the Gesellschaft fuer Nuklearmedizin, which took place in Madrid on October 24-27, 1978, contains 183 compacts on the following subjects: Metrology and data processing, cyclotron products and radiopharmaceuticals, nuclear medicine as compared with computerized tomography and sonography, radioimmunoassay, haematology, thyreology, osteology, pulmonology, cardiology, angiology, nephrology, gastroenterology and hepatology, oncology, nuclear therapy methods and some free lectures and thus give a good picture of the state of the art in nuclear medicine at the time.

  7. Environmental biotechnology for the eco-efficient decontamination of petroleum hydrocarbon polluted sites in the NIS

    International Nuclear Information System (INIS)

    Kerstin, S.; Andreas, P. L.; Hildegard, A.

    2005-01-01

    Full text : Pollution of soil and ground water with petroleum hydrocarbons is a major environmental problem in many oil producing regions of the New Independent States. Decontamination of these areas using conventional technologies based on physical, chemical and / or thermal pollutant removal would require major financial resources and represent a great economical burden for these regions. Thus, contaminated land management (CLM) has to focus on efficient yet low-cost strategies yielding the optimum ecological outcome. Approaching such eco-efficient, i.e ecologically sound and economically feasible solutions includes the consideration of technical, scientific and socio-economic aspects. A comprehensive risk assessment states the basis for these CLM strategies, which considers both technical (e.g. soil type, groundwater characteristics) and regional aspects (e.g. demographic and socio-economic details). This requires a holistic understanding of these capacious problems and its communication to and the involvement of the stakeholders. Such eco-efficient technologies that are suitable for the clean-up of soils and aquifers polluted with organic chemicals (e.g. crude oil and its derivatives) are offered by environmental biotechnology. Decontamination techniques such as bioremediation, based on the engineered promotion of the soil's intrinsic microbiological capability to recover from environmental stresses, are fit to re-establish acceptable environmental conditions on a reasonable time-scale while requiring comparably little resources. Bioremediation techniques may be applied after excavation of the polluted soil (ex situ) or on the site as is, leaving contaminated material in place (in situ). Surface, ex situ, treatment (biopiles, landfarming) facilitates the homogenous addition of additives such as surfactants, nutrients or pollutant degrading microorganisms. By contrast, in situ technologies (e.g. bioventing, biosparging) are, as they do not require soil excavation, more cost-efficient. In addition, these state the only alternative in case the soil is not to be removed, or for sites covered with buildings. Thus, bioremediation strategies are offered for and can be implemented on a wide range of boundary conditions. Considering the comparably low remediation costs, the sustainability, ecoefficiency and public acceptance of biotechnological processes, these techniques represent a highly efficient toolbox for the reduction of risk posed by polluted sites. Other than in Europe, where two decades of experience exists, the implementation of CLM strategies is limited in the New Independent States. In Azerbaijan, laboratory facilities and expert know how in oil chemistry and exploration is available, but environmental aspects have long been underestimated. Moreover, the integration of socio-economic aspects into CLM strategies has not gone very far neither in these countries nor in Europe

  8. Fourth National Incidende Study of Child Abuse and Neglect (NIS-4)

    Data.gov (United States)

    U.S. Department of Health & Human Services — NIS–4 data were collected to provide updated estimates of the incidence of child abuse and neglect in the United States and measure changes in incidence from the...

  9. A Case Study of the NATO Identification System (NIS) Codevelopment Program

    Science.gov (United States)

    1988-09-01

    the otherhand are unrelated to the military equipment being purchased. These offsets include foreign investment, technology transfer, and countertrade ...manufacturer and a foreign entity. 6. Countertrade - a transaction that specifies the exchange of selected goods and services for another of equivalent...arrangements. In fact, U.S. agencies are permitted to provide advisory and marketing intelligence services to U.S. exporters involved in countertrade

  10. Deliverable D8.4 - Report on Collaboration with Standardization Bodies, NIS and Other External Groups

    OpenAIRE

    Papastergiou, Spyros; Karantjias, Thanos; Chatzikou, Menia; Vidali, Peggy; Douligeris, Christos; Stavrakakis, Ioannis; Kalogeraki, Eleni-Maria; Zacharias, Marios; Purcarea, Razvan; Cocor, Gabriel; Schauer, Stefan; König, Sandra; Mouratidis, Haris; Pavlidis, Michalis; Polatidis, Nikolaos

    2018-01-01

    Despite the importance of Critical Information Infrastructures (CIIs) and dynamic ICT‐based maritime supply chains (SCs) for port operations, state‐of‐the‐art Risk Management (RM) methodologies for maritime environments pay limited attention to cyber‐security and do not adequately address security processes for international SCs. Motivated by these limitations, MITIGATE will introduce, integrate, validate and commercialize a novel RM system, which will empower stakeholders’ collaboration for ...

  11. NIS method for uncertainty estimation of airborne sound insulation measurement in field

    Directory of Open Access Journals (Sweden)

    El-Basheer Tarek M.

    2017-01-01

    Full Text Available In structures, airborne sound insulation is utilized to characterize the acoustic nature of barriers between rooms. However, the assessment of sound insulation index is once in a while troublesome or indeed, even questionable, both in field and laboratory measurements, notwithstanding the way that there are some unified measurement methodology indicated in the ISO 140 series standards. There are issues with the reproducibility and repeatability of the measurement results. A few troubles might be brought on by non-diffuse acoustic fields, non-uniform reverberation time, or blunders of the reverberation time measurements. Some minor issues are additionally postured by flanking transmission. In this paper, investigation of the uncertainties of the above specified measurement parts and their impact on the consolidated uncertainty in 1/3-octave frequency band. The total measurement uncertainty model contributes several different partial uncertainties, which are evaluated by the method of type A or type B. Also, the determination of the sound reduction index decided by ISO 140-4 has been performed.

  12. NIS occurrence - Non-native species impacts on threatened and endangered salmonids

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The objectives of this project: a) Identify the distribution of non-natives in the Columbia River Basin b) Highlight the impacts of non-natives on salmonids c)...

  13. Rahvuslik - kohustuslik publikupüünis / Anneli Aasmäe

    Index Scriptorium Estoniae

    Aasmäe, Anneli, 1973-

    2001-01-01

    Muusikalidest Eesti lavadel - 23. veebr. esietendub Pärnu Endlas "Hea lugu", 11. märtsil Vanemuises "Verevennad", 16. märtsil Tallinna Linnahallis "No, No, Nanette" ja 2. nov Tallinna Linnahallis "Hüljatud"

  14. Test program for NIS calibration to reactor thermal output in HTTR

    International Nuclear Information System (INIS)

    Nakagawa, Shigeaki; Shinozaki, Masayuki; Tachibana, Yukio; Kunitomi, Kazuhiko

    2000-03-01

    Rise-to-power test program for reactor thermal output measurement has been established to calibrate a neutron instrumentation system taking account of the characteristics of the High Temperature Engineering Test Reactor (HTTR). An error of reactor thermal output measurement was evaluated taking account of a configuration of instrumentation system. And the expected dispersion of measurement in the full power operation was evaluated from non-nuclear heat-up of primary coolant up to 213degC. From the evaluation, it was found that an error of reactor thermal output measurement would be less than ±2.0% at the rated power. This report presents the detailed program of rise-to-power test for reactor thermal output measurement and discusses its measurement error. (author)

  15. Integrity of the core mitochondrial RNA-binding complex 1/nis vital for trypanosome RNA editing

    Czech Academy of Sciences Publication Activity Database

    Huang, Zhenqiu; Faktorová, Drahomíra; Křížová, A.; Kafková, L.; Read, L. K.; Lukeš, Julius; Hashimi, Hassan

    2015-01-01

    Roč. 21, č. 12 (2015), s. 2088-2102 ISSN 1355-8382 R&D Projects: GA ČR GA15-21974S EU Projects: European Commission(XE) 289007 Institutional support: RVO:60077344 Keywords : RNA editing * mitochondrion * trypanosome Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 4.344, year: 2015

  16. MV-NIS or Investigator's Choice Chemotherapy in Treating Patients With Ovarian, Fallopian, or Peritoneal Cancer

    Science.gov (United States)

    2018-04-27

    Fallopian Tube Transitional Cell Carcinoma; Malignant Ovarian Clear Cell Tumor; Malignant Ovarian Endometrioid Tumor; Malignant Ovarian Serous Tumor; Ovarian Seromucinous Carcinoma; Ovarian Transitional Cell Carcinoma; Primary Peritoneal Serous Adenocarcinoma; Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma; Undifferentiated Fallopian Tube Carcinoma; Undifferentiated Ovarian Carcinoma

  17. NisC Binds the FxLx Motif of the Nisin Leader Peptide

    NARCIS (Netherlands)

    Abts, Andre; Montalban-Lopez, Manuel; Kuipers, Oscar P.; Smits, Sander H.; Schmitt, Lutz

    2013-01-01

    Nisin is a model system for lantibiotics, a class of peptides displaying antimicrobial activity against various Gram-positive bacteria. After ribosomal synthesis, the precursor peptide is modified in two steps, of which the last one involves consecutive cyclization reactions mediated by the cyclase

  18. An assessment of environmental damage caused by NATO bombing of NIS Jugopetrol facilities

    International Nuclear Information System (INIS)

    Milosevic, D.; Radu, A.; Novakovic, J.

    2002-01-01

    This paper present our investigation of the effects of NATO bombing of the Jugopetrol facilities in Serbia during the Spring of 1999. Concentrations of hazardous material in air, water and soil have been measured and compared to the situation before the bombing. Only partial results are presented in this paper. High concentrations of hydrocarbons were detected in the air immediately after the bombing and the destruction of installations, due to burning and evaporation of oil derivatives. A great amount of spilled mineral oils has been detected in water and soil near the destroyed installations. We have detected a noticeable increase in pollution after the NATO bombing. In addition to above mentioned pollution, the destruction of large parts of waste treatment system within the Jugopetrol's installations caused severe environmental problems. The recovery of the destroyed installation and waste treatment systems require considerable amount of money and time, and cannot be accomplished without the help of foreign investment. (author)

  19. SUSCEPTIBILITY OF RESPIRATORY ISOLATES OF STREPTOCOCCUS PNEUMONIAE ISOLATED FROM CHILDREN HOSPITALIZED IN THE CLINICAL CENTER NIS.

    Science.gov (United States)

    Dinić, Marina M; Mladenović Antić, Snezana; Kocić, Branislava; Stanković Dordević, Dobrila; Vrbić, Miodrag; Bogdanović, Milena

    2016-01-01

    Streptococcus pneumoniae is one of the most common causes of respiratory infections. The aim was to study the susceptibility to antimicrobial agents of respiratory isolates ofStreptococcus pneumoniae obtained from hospitalized children. A total of 190 respiratory pneumococcal isolates obtained from children aged from 0 to 14 years were isolated and identified by using standard microbiological methods. Susceptibility to oxacillin, erythromycin, clindamycin, tetracycline, cotrimoxazole, ofloxacin and rifampicin was tested by disc diffusion method. Minimal inhibitory concentrations for amoxicillin and ceftriaxone were determined by means of E test. The macrolide-resistant phenotype was detected by double disc diffusion test. All tested isolates were susceptible to amoxicillin and ceftriaxone. The minimal amoxicillin concentration inhibiting the growth of 50% of isolates and of 90% of isolates was 0.50 microg/ml and 1.0 microg/ml, respectively and the minimal ceftriaxone concentration inhibiting the growth of 50% of isolates and of 90% of isolates was 0.25 microg/ml and 0.50 microg/ml, respectively. Susceptibility to erythromycin and clindamycin was observed in 21.6% and 29.47% of isolates, respectively. The resistence to macrolides-M phenotype was detected in 10.07% of isolates and constitutive macrolide-lincosamide-streptogramin phenotype (constitutive MLS phenotype) was found in 89.93% of isolates. All tested isolates were susceptible to ofloxacin and rifampicin. Amoxicillin could be the therapy of choice in pediatric practice. The macrolides should not be recommended for the empirical therapy of pneumococcal respiratory tract infection in our local area.

  20. U.S. Nuclear Regulatory Commission nuclear safety assistance to the CEE and NIS countries

    International Nuclear Information System (INIS)

    Blaha, J.

    2001-01-01

    NRC participates in bilateral and multilateral efforts to strengthen the regulatory authorities of countries in which Soviet design NPPs are operated. Countries involved are the New Independent States of the Soviet Union (Armenia, Kazakhstan, Russia and Ukraine) and of Central and Eastern Europe (Bulgaria, Czech Republic, Hungary, Lithuania and Slovak Republic). NRC's goal is to see that its counterparts receive the basic tools, knowledge and understanding needed to exercise effective regulatory oversight, consistent with internationally accepted norms and standards. The bilateral assistance started in 1991. $44 mill. are provided to the countries. The multilateral activities NRC participates in include: H-7 Nuclear Safety Working Group, EBRD - Administered Nuclear Safety Account and Chernobyl Sarcophagus Fund and IAEA

  1. EXPERIENCE WITH ROBOTIC LUMЕNIS CO LASER IN ENDOSCOPIC LARYNGEAL SURGERY

    Directory of Open Access Journals (Sweden)

    E. N. Novozhilova

    2014-01-01

    Full Text Available  2 The paper describes the first experience in using robotic CO laser at the Department of Head and Neck Tumors, Moscow City Cancer Hospital Sixty-Two. With advances in endoscopic techniques and anesthesiology, there have been new possibilities of usingdirect (rigid larygoscopy in conjunction with laser systems.The Lumеnis laser assembly consists of three interconnected components: a videocamera, an operating microscope, and directly CO laser. It includes a computer system that sets a program to perform an operation.The heart of the laser system is a scanning Digital Acu Blade micromanipulator. This unique assembly makes itpossible to control the area and depth of incision, to cut intricate shapes in relation to the surface anatomy, and to precisely control ablation and hemostasis. The effect of tissue carbonization during surgery is minimal at the expense of the physical characteristics and different modes of radiation. It is noted that this system allows organ-sparing treatment in cancer patients and their prompt rehabilitation after surgical interventions.

  2. Pendrin and NIS antibodies are absent in healthy individuals and are rare in autoimmune thyroid disease

    DEFF Research Database (Denmark)

    Brix, Thomas H; Hegedüs, Laszlo; Weetman, Anthony P

    2014-01-01

    prevalence than the controls: NISAb: 17% vs 0% (P Graves' disease (GD) and 14% (5/37) of patients with Hashimoto's thyroiditis (HT) had NISAb, (P ...OBJECTIVE: Antibodies against thyroglobulin, thyroid peroxidase and the TSH receptor are accepted as pathophysiological and diagnostic biomarkers in autoimmune thyroid disease (AITD). In contrast, the prevalence, aetiology and clinical relevance of autoantibodies against the human sodium...

  3. Shared Investment by NIS and National Labs Develops Cutting-Edge Safeguards Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Anheier, Norman C.; Williams, Laura S.

    2012-04-01

    This article, regarding a new technology for detecting undeclared enrichment at gas centrifuge enrichment plants, was written for the DOE/NNSA NA-24 Highlights, a newsletter intended for public release.

  4. Zur Bedeutung von Totholz aus arachnologischer Sicht. Auswertung von Eklektorfängen aus einem niedersächsischen Naturwald

    Directory of Open Access Journals (Sweden)

    Muster, Christoph

    1998-07-01

    Full Text Available The communities of bark-dwelling spiders and false scorpions on standing trunks of living and dead oaks (Quercus robur of various stages were studied in an ancient woodland in the lowland of NW-Germany. The investigations were carried out from march to october 1996 by use of 28 emergencs traps. For comparative purpose one stem-eclector was used. All traps were installed at a height of 2 meters. The appropriateness of these methods for collecting spiders is discussed. A total of 1828 spiders (41 species and 57 false scorpions (1 species were encountered. Abundance gradients are analysed with regard to bark-structure, insolation and age of dead wood. Three species are first recorded in the NW-German Plan: Dipoena torva, Haplodrassus cognatus and Synema globosum. Hitherto the predominant spieders Thyreosthenius parasiticus and Haplodrassus cognatus have not been found on bark abundantly. Thus, the structure of the bark-dwelling fauna varies considerably with region, biotope structure and historical aspects. The occurence of Dendrochernes cymeus, which in Britain is associtated with ancient woodlands, indicates that this species could be restricted to such woodlands in Northern Germany, too.

  5. Significance of international hydropower storages for the German energy turnaround; Bedeutung der internationalen Wasserkraftspeicherung fuer die deutsche Energiewende

    Energy Technology Data Exchange (ETDEWEB)

    Hobohm, Jens; Ess, Florian [Prognos AG, Berlin (Germany)

    2013-01-15

    Prediction is very difficult, especially if it's about the future. This witticism, which has been alternatively ascribed to Mark Twain, Karl Valentin, Niels Bohr and Winston Churchill, could hardly be truer than when applied to the wind and sun, especially in the case of long-term forecasts. Wind power and photovoltaic plant capacities are what needs to grow most if renewable energies really are to cover 80% of Germany's energy supply by the year 2050. Other renewable energy resources do not have the potential to contribute substantially to achieving the goals proclaimed by the German federal government. Some 64% of electricity production and 70% of installed power capacity will be coming from the wind and sun in the year 2050, according to recent calculations. A study prepared by Prognos AG on behalf of the German National Committee of the World Energy Council has investigated the question as to what extent international hydropower storages are capable of taking up surplus electricity and holding it available as a power reserve.

  6. Hepatologie Neuere Forschungsergebnisse in ihrer Bedeutung für das Verständnis von Leberkrankheiten

    Science.gov (United States)

    Gerok, W.; Blum, H. E.; Offensperger, W.; Offensperger, S.; Andus, T.; Groß, V.; Heinrich, P. C.

    1991-06-01

    By two exemplary clinical situations — acute viral hepatitis, acute-phase reaction of the liver — the significance of basic research for the understanding of clinical phenomena and for the development of new diagnostic and therapeutic procedures is demonstrated. The very different phenomena following infection with the hepatitis-B-virus can be explained by the variation in the interactions of virus and liver cell, by the immune reaction of the host, and by mutants of the virus. The reaction of the liver to an extrahepatic infection is mediated by interleukin-6, and characterized by an alteration in protein metabolism. The synthesis of acute-phase proteins is increased. The proteins confine the local injury and establish the homeostasis of the organism.

  7. Evaluation and importance of the environmental concern within the environmental medicine; Erfassung und Bedeutung der Umweltbesorgnis in der Umweltmedizin

    Energy Technology Data Exchange (ETDEWEB)

    Rethage, T.

    2007-07-01

    The book discusses the importance of environmental concerns and annoyance in connection with health-related parameters, such as discomfort, health-related life quality and sleep quality. The evaluation methods and materials (definition of evaluated collectives) are described. The discussion covers the characterization of environmental concerns, their multi-dimensionality and the concerns in case of specific exposures (smells, noise, electromagnetic fields, environment medical ambulance).

  8. The macro economic relevance of renewable energy sources for Switzerland; Volkswirtschaftliche Bedeutung erneuerbarer Energien fuer die Schweiz

    Energy Technology Data Exchange (ETDEWEB)

    Nathani, C.; Schmid, C.; Rieser, A.; Ruetter, H. [Ruetter und Partner, Rueschlikon (Switzerland); Bernath, K.; Felten, N. von [Ernst Basler und Partner, Zollikon (Switzerland); Walz, R.; Marscheider-Weidemann, F. [Fraunhofer Institut fuer System- und Innovationsforschung, Karlsruhe (Germany)

    2013-01-15

    This study analyses the economic relevance of renewable energy in Switzerland. In 2010 the enterprises in the renewable energy sector generated a gross value added of 4.8 bn CHF (equalling 0.9% of Swiss GDP). Employment in this sector approximated 22,800 fulltime jobs (0.6% of total Swiss employment). Including supply chain companies, 1.5% of Swiss GDP and 1.2% of total employment can be related to the use of renewable energy. Exports of renewable energy related goods and services equalled 3.2 bn CHF. Since 2000 the Swiss renewable energy sector has experienced an above-average annual growth of more than 4%. Its potential development until the year 2020 was studied with two scenarios. In the policy scenario, that assumes additional policy measures for renewable energy promotion, direct value added of the renewable energy sector would amount to 6.4 bn CHF (+33%), direct employment would increase to 29,200 fulltime jobs (+28%, gross effects resp.). In the more conservative baseline scenario, growth would be much weaker, but still slightly stronger than anticipated for the average economy. (authors)

  9. Verletzungsschwere und -lokalisationen polytraumatisierter Kinder im Vergleich zu Erwachsenen und deren Bedeutung für das Schockraummanagement

    DEFF Research Database (Denmark)

    Zwingmann, J; Schmal, H; Südkamp, N P

    2008-01-01

    PURPOSE: The treatment of paediatric polytrauma patients in the emergency room is not common. The knowledge of specific injuries in consideration of the age-specific characteristics is of particular importance for precise diagnostics and therapy. The goal of this study is the aquisition of the fr......PURPOSE: The treatment of paediatric polytrauma patients in the emergency room is not common. The knowledge of specific injuries in consideration of the age-specific characteristics is of particular importance for precise diagnostics and therapy. The goal of this study is the aquisition...... of the frequency, the localisation and the severity of paediatric polytrauma (age: 0-16 years) in comparison with adults. PATIENTS AND METHODS: In the period 7 / 01 to 5 / 04 the localisation and injury severity of 23 paediatric polytrauma patients (age: 2-16 years) were compared retrospectivly with those of 324...

  10. The strategic role of district heating in renewable energy use; Die strategische Bedeutung der Nahwaerme zur Nutzung erneuerbarer Energien

    Energy Technology Data Exchange (ETDEWEB)

    Nast, M. [Deutsches Zentrum fuer Luft- und Raumfahrt e.V. (DLR), Stuttgart (Germany). Abt. Systemanalyse und Technikbewertung; Boehnisch, H. [Zentrum fuer Sonnenenergie- und Wasserstoff-Forschung Baden-Wuerttemberg (ZSW), Stuttgart (Germany)

    1998-02-01

    District heating allows the utilization of biomass in low emission heating plants, the exploitation of solar energy and the seasonal storage of heat. If a sustainable energy supply system is to be created, district heating must not only be the system of choice for new housing districts but must also be retrofitted in existing settlements. The detailed analysis of a rural community shows that large segments of existing buildings can be connected to district heating systems even in regions with predominantly single dwellings and rural housing densities. The conditions necessary for establishing district heating systems are discussed. (orig.) [Deutsch] Nahwaermesysteme ermoeglichen, fossile und biogene Brennstoffe einzusetzen und lassen sich an saisonale Waermespeicher anschliessen. Zum Aufbau einer nachhaltigen Energieversorgung ist Nahwaerme nicht nur in Neubaugebieten notwendig sondern muss auch in den schon laenger genutzten Gebaeudebestand integriert werden. Das Beispiel einer umfassend analysierten Landgemeinde zeigt, dass ein grosser Teil des bestehenden Gebaeudebestandes an Waermenetze angeschlossen werden kann, selbst bei vorherrschender Bebauung mit Einfamilienhaeusern und laendlichen Gebaeudedichten. Die notwendigen Rahmenbedingungen fuer den Aufbau einer Nahwaermeversorgung werden erlaeutert. (orig.)

  11. Significance and occurrence of gas hydrates in offshore areas; Bedeutung und Vorkommen von Gashydraten im Offshore-Bereich

    Energy Technology Data Exchange (ETDEWEB)

    Wehner, H.; Faber, E. [Bundesanstalt fuer Geowissenschaften und Rohstoffe, Hannover (Germany)

    1997-12-31

    The present contribution describes the boundary and stability conditions under which gas hydrates are able to exist. It also discusses the occurrence and genesis of gas hydrates and their role as an energy raw material of the future. Furthermore, it deals with the possibility of gas hydrates being the cause of submarine slumps and with their influence on the climate. (MSK) [Deutsch] Die Rand-und Stabilitaetsbedingungen unter denen die Gashydrate existent sein koennen werden beschrieben. Ebenso wird das Vorkommen von Gashydraten, ihre Genese und ihre Rolle als Energierohstoff der Zukunft diskutiert. Darueberhinaus werden die Gashydrate als moegliche Ursache fuer untermeerische Rutschungen und ihr Einfluss auf Klimaaenderungen erlaeutert.

  12. Man and room climate. The importance of thermal comfort; Der Mensch und das Raumklima. Zur Bedeutung der thermischen Behaglichkeit

    Energy Technology Data Exchange (ETDEWEB)

    Hoefte, Klaus [Uponor Academy, Ochtrup (Germany)

    2009-07-01

    Room climate has become increasingly important during the past few decades as humans spend about 90 percent of their time inside rooms. Influencing factors are acoustics, lighting, air quality and thermal room climate. The contribution focuses on thermal room climate and room air quality which are the most important of these factors. (orig.)

  13. Die Bedeutung von Infinitiv und Konjunktiv als Modi der Nicht-Mitteilung (unter besonderer Berücksichtigung des Italienischen

    Directory of Open Access Journals (Sweden)

    Pichler, Claudia

    Full Text Available The infinitive (also referred to as "Nennform" is positioned both formally and functionally between noun and verb. This so-called "intermediate status" and the pragmatic-communicative characteristics/functions resulting from it are described on the basis of a selection of Old Italian language samples. The study therefore examines the correlation between morphosyntactic and informational structure and focuses in particular on the morphosyntactic codification of thematic elements of expression. An accordance can be ascertained regarding the pragmatic-communicative characteristics/functions of the infinitive ( i.e. infinitive constructions of the type: definite article + infinitive + subject and the (thematic subjunctive.

  14. Die Bedeutung von Musiker- und Komponistenbriefe für die regionale und europäische Kulturgeschichte

    Directory of Open Access Journals (Sweden)

    Buschmeier Gabriele

    2002-01-01

    Full Text Available (nemački Die Entwicklung der Musikkultur insbesondere in Mittel- und Osteuropa ist von einem äußerst regen Austausch und lebendigen Beziehungen gekennzeichnet. Die Dokumente dieser Beziehungen sind zum Teil die erhaltene Briefe. Für den Musikwissenschaftler sind dabei alle Arten von Briefen sowohl privaten als auch geschäftlichen Charakters, von Interesse und zwar nicht nur Briefe von den sogenannten "Heroen" der Musikgeschichte, sondern insbesondere auch von nur lokal bekannten Musikern oder Menschen, die sich mit Musik beschäftigen.

  15. Die Bedeutung von Fetuin-A für Proliferation und Fibrogenese im Knockout-Modell

    OpenAIRE

    Stojanov, Sabrina

    2009-01-01

    The human cirrhosis of the liver is a progressive illness with serious clinical results, like portal hypertension and terminal functional loss of the organ. At the end stands the liver transplant or the exitus letalis, not to forget the strongly raised prevalence for the hepatocellular carcinoma. For these reasons it is essential to develop new therapy concepts with views of forecast improvement or even healing. With a knockout model of the mouse we examined the effect of fetuin-A for physiol...

  16. Freundschaftsbeziehungen in Zeiten sozialer Onlinenetzwerke – Die Bedeutung von Freundschaft für das Selbstkonzept Jugendlicher

    OpenAIRE

    Krafzick, Svenja; Schmidt, Esther

    2017-01-01

    Freundschaften sind und bleiben wichtig für die Persönlichkeitsentwicklung im Jugendalter, weil sie entscheidende soziale Ressourcen für das Leben darstellen. Durch soziale Medien entstehen neue Möglichkeiten aber auch Herausforderungen für die Freundschaftspflege. In der vorliegenden empirischen Arbeit werden mittels einer qualitativen Befragung von Jugend-lichen (n = 59) vier Freundschaftstypen identifiziert – die/der Traditionelle, die/der Modern-Traditionelle, die/der Onliner/in und die/d...

  17. Zur Bedeutung der Pharmakogenetik in der Veterinärmedizin am Beispiel des MDR1-Gendefektes beim Hund

    OpenAIRE

    Geyer, Joachim

    2014-01-01

    Die Pharmakogenetik untersucht, inwieweit Variationen in Genen, welche die pharmakokinetischen und pharmakodynamischen Prozesse eines Arzneistoffes kontrollieren für die interindividuellen Unterschiede in der Arzneistoffwirkung oder dem vermehrten Auftreten unerwünschter Arzneistoffwirkungen verantwortlich sind. Die pharmakogenetische Forschung hat in der Humanmedizin in den vergangenen 10-20 Jahren große Fortschritte erzielt, wobei die auf eine personalisierte Medizin ausgerichtete Berücksic...

  18. Hydrologische Vernetzung und ihre Bedeutung für diffuse Nährstoffeinträge im Hotzenwald/Südschwarzwald

    OpenAIRE

    Schneider, Philipp

    2007-01-01

    In order to meet the goals of the Water Framework Directive (WFD) – namely the sustainable improvement of water quality – it is necessary to reduce diffuse nutrient inputs. Diffuse nutrient inputs – primarily of phosphorus (P) and nitrogen (N) – are of public interest due to their negative ecological effects on surface water quality. Lakes, especially their trophic status, are natural indicators reflecting anthropogenic impacts on aquatic systems in that they integrate nutri...

  19. The importance of risk models for management of pulmonary nodules; Die Bedeutung von Risikomodellen fuer das Management pulmonaler Rundherde

    Energy Technology Data Exchange (ETDEWEB)

    Prosch, H.; Baltzer, P. [Medizinische Universitaet Wien, Allgemeines Krankenhaus, Universitaetsklinik fuer Radiologie und Nuklearmedizin, Wien (Austria)

    2014-05-15

    Pulmonary nodules are a frequent finding in computed tomography (CT) investigations. Further diagnostic work-up of detected nodules mainly depends on the so-called pre-test probability, i.e. the probability that the nodule is malignant or benign. The pre-test probability can be calculated by combining all relevant information, such as the age and the sex of the patient, the smoking history, and history of previous malignancies, as well as the size and CT morphology of the nodule. If additional investigations are performed to further investigate the nodules, all results must be interpreted taking into account the pre-test probability and the test performance of the investigation in order to estimate the post-test probability. In cases with a low pre-test probability, a negative result from an exact test can exclude malignancies but a positive test cannot prove malignancy in such a setting. In cases with a high pre-test probability, a positive test result can be considered as proof of malignancy but a negative test result does not exclude malignancy. (orig.) [German] Pulmonale Rundherde sind ein haeufiger Befund bei CT-Untersuchungen des Thorax. Die weiterfuehrende Abklaerung der gefunden Rundherde haengt im Wesentlichen von der so genannten Vortestwahrscheinlichkeit ab, der Wahrscheinlichkeit ob der Rundherd maligne ist oder nicht. Diese Vortestwahrscheinlichkeit laesst sich durch die Kombination aller relevanten Vorinformationen wie Alter und Geschlecht des Patienten, Raucheranamnese, Tumoranamnese, Groesse und CT-Morphologie des Rundherdes genau berechnen oder intuitiv abschaetzen. Werden weiterfuehrende Untersuchungen zur Abklaerung des Rundherdes durchgefuehrt, ist das Ergebnis dieser Untersuchung, die Nachtestwahrscheinlichkeit fuer das Vorliegen von Malignitaet, in Abhaengigkeit von der Vortestwahrscheinlichkeit und der Testguete der Untersuchung zu interpretieren. Waehrend ein genauer Test im Falle niedriger Vortestwahrscheinlichkeiten Malignitaet mit Sicherheit ausschliessen kann, ist ein positives Testergebnis in einem solchen Setting niemals als 100 %ig sicher einzustufen. Umgekehrt verhaelt es sich im Falle sehr hoher Vortestwahrscheinlichkeiten: hier kann eine positive Diagnose als sicher angenommen, der Ausschluss der Erkrankung jedoch nur als unsicher eingestuft werden. (orig.)

  20. The value of MRI in the diagnosis of cerebral infection. Die Bedeutung der Kernspintomographie in der Diagnostik zerebraler Infektionen

    Energy Technology Data Exchange (ETDEWEB)

    Glathe, S.; Heindel, W.; Steinbrich, W. (Koeln Univ. (Germany, F.R.). Inst. fuer Radiologische Diagnostik)

    1989-09-01

    Amongst 1.345 MR examinations of the skull 49 patients were suspected of a cerebral infection. With a knowledge of the clinical situation, the abnormal findings were classified according to their localization, number, extent and distribution. The final diagnoses included meningitis, meningo-encephalitis, and abscesses of varying etiology. CT was carried out in 29 patients; it was found that MRI was more sensitive and able to show the lesion at an earlier stage (sensitivity 90% compared with 66%). Observations of proton density and relaxation time combined with morphological criteria and clinical history reduced differential diagnoses. On the other hand, the changes due to intracranial infections lead to an inflammatory reaction that may be similar to the findings in degenerative or even tumorous cerebral lesions. This explains why twelve patients with abnormal MRI findings were erroneously diagnosed as having cerebral infections. (orig.).

  1. Caritas in Veritate – die Bedeutung von Liebe und Wahrheit für eine gute Gesellschaft

    Directory of Open Access Journals (Sweden)

    Józef Młyński

    2014-04-01

    Full Text Available Love and truth are the two attributes of a well-functioning society. Unfortunately, these two basic values are often being devalued in the modern world. The reason for this is the lack of a sense of justice. Especially because in the social and cultural context the truth is often relativized. In this context it is worth analysing the Pope Benedict XVI’s encyclical Caritas in Veritate , in which one should pay attention to a construction of the society in which today’s human person lives. Love and truth are the two attributes of a good society in with each human is equipped. From the very beginning, the human person is called to be directed by love and truth. He or she is called to this truth by his or her Christian life and ontic dimension of his or her nature. Society without love and truth will be threatened with agony, because it will not only stop developing but also its wrongly understood economical status will become a road to nowhere. That is why we should definitely accept the thesis that homo economicus must convert into homo religiosus in the name of love and truth, so that society will be good. Let love in truth leads to a good society, which the whole world is for us.

  2. Combined Natural Gas and Solar Technologies for Heating and Cooling in the City of NIS in Serbia

    Science.gov (United States)

    Stefanović, Velimir P.; Bojić, Milorad Lj.

    2010-06-01

    The use of conventional systems for heat and electricity production in Niš and Serbia means a constant waste of energy, and money. This problem is present in both industrial and public sector. Using conventional systems, means not only low-energy efficient systems, and technologies, but also using very "dirty" technologies, which cause heavy environment pollution. The lack of electricity in our country, and region is also present. The gas pipeline in Niš was finished not long ago, and second gas pipeline is about to be made in the next couple of years. This opens a door for implementing new technologies and the use of new methods for production of heat and electricity, while preserving our environment. This paper reports discussion of this technology with management of public institutions, which use both heat and electricity.

  3. Temporal Trends in Percutaneous Coronary Intervention Associated Acute Cerebrovascular Accident (From the 1998–2008 Nationwide Inpatient Sample [NIS] Database)

    Science.gov (United States)

    Shivaraju, Anupama; Yu, Changhong; Kattan, Michael W.; Xie, Hui; Shroff, Adhir R.; Vidovich, Mladen I.

    2014-01-01

    Acute cerebrovascular accident (CVA) after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) and coronary artery disease (CAD) is associated with high morbidity and mortality. Nationwide Inpatient Sample from 1998 to 2008 was utilized to identify 1,552,602 PCIs performed for ACS and CAD. We assessed temporal trends in the incidence, predictors and prognostic impact of CVA in a broad range of patients undergoing PCI. The overall incidence of CVA was 0.56% (95% confidence interval (CI), 0.55%–0.57%). The incidence of CVA remained unchanged over the study period (adjusted p for trend = 0.2271). The overall mortality in the CVA group was 10.76% (95% CI, 10.1%–11.4%). The adjusted odds ratio (OR) of CVA for in-hospital mortality was 7.74 (95% CI, 7.00–8.57; p<0.0001); this remained high but decreased over the study period (adjusted p for trend <0.0001). Independent predictors of CVA included older age (OR, 1.03, 95% CI, 1.02–1.03; p<0.0001), disorder of lipid metabolism (OR, 1.31, 95% CI, 1.24–1.38; p<0.001), history of tobacco use (OR, 1.21, 95% CI, 1.10–1.34; p=0.0002), coronary atherosclerosis (OR 1.56, 95% CI, 1.43–1.71; p<0.0001), and IABP use (OR 1.39, 95% CI, 1.09–1.77; p=0.0073). A nomogram for predicting the probability of CVA achieved a concordance index of 0.73 and was well calibrated. In conclusion, the incidence of CVA associated with PCI has remained unchanged from 1998–2008 in face of improved equipment, techniques and adjunctive pharmacology. The risk of CVA associated in-hospital mortality is high; however, this risk has declined over the study period. PMID:24952927

  4. COPING WITH AND MANAGING STRESS STYLES OF FRESHMEN PHYSICAL EDUCATION STUDENTS AT THE PE FACULTY IN NIS

    Directory of Open Access Journals (Sweden)

    Danica Pirsl

    2005-05-01

    Full Text Available Stress is frequently viewed as an enemy. This is a misconception. Stress is often neither positive nor negative. Selye referred to stress judged as "good" as eustress. Distress, on the other hand, is stress that results in negative responses. Unchecked negative stress can interfere with the physiological and psychological functioning of the body and may ultimately result in disease or disability. A stressor is any physical, psychological or environmental event, or condition that initiates the stress. The body responds with the same threestage process. This series of changes is known as the general adaptation syndrome (GAS. The three phases are alarm, resistance, and exhaustion. It is interesting to note that PE students form their own stress copying styles in the mental, emotional and physical areas. Results are enhanced activities, sense of control and high energy level. Both male and female students show similar patterns of behaviour in stressful situations but female students show more interest in sporting activities when in stress-related situation

  5. Trends in records and contribution of non-indigenous species (NIS) to biotic communities in Danish marine waters

    DEFF Research Database (Denmark)

    Stæhr, Peter Anton; Jakobsen, Hans Henrik; Hansen, Jørgen L.S.

    The report investigates trends in the temporal and spatial changes of non-indigenous marine species in the Danish part of the OSPAR and HELCOM regions. The assessment is based on a quantitative analysis of data available in national monitoring databases and covers the period 1989 to 2014 and othe...

  6. „lauter Erfahrungs-Sachen“ – Gerhard Tersteegens Lied „Gott ist gegenwärtig“ – Bedeutung und Rezeption

    Directory of Open Access Journals (Sweden)

    Ruth Nientiedt

    2013-05-01

    Full Text Available Hymnology and hymnal studies are working interdisciplinary: History, linguistics, literary science and theology, especially the liturgical perspective, are being brought together and can provide valuable insight to social history and the history of mentality. Unfortunately this potential is rarely seen or acted upon. This paper on Tersteegens song Gott ist gegenwärtig gives an example of the possibilities of hymnology and hymnal studies. It also evinces Tersteegens interdenominational importance as a mystic. In the course of this enquiry terms like ‘pietism’ and ‘mysticism’ are outlined and set into the context of the Enlightment and the history of hymnals. Following this line of thought, it is to be ascertained how suitable the categories ‘pietist’ and ‘mystic’ are to describe Tersteegen and how important singing was to him personally. In the final analysis possible interpretations of Tersteegens song Gott ist gegenwärtig are brought to attention and the reception of his work in several hymn books is illustrated. The history of reception draws from the stock of the hymnal archive of the IAK Gesangbuchforschung.

  7. Radiography of the equine thorax and its differential diagnosis relevance; Die differenzialdiagnostische Bedeutung der röntgenologischen Thoraxuntersuchung beim Pferd

    Energy Technology Data Exchange (ETDEWEB)

    Klein, H. J. [Klinik fuer Pferde, Tieraerztliche Hochschule Hannover (Germany); Offeney, F.

    1990-07-01

    Commonly chronic obstructive pulmonary disease (COPD) is the cause of dyspnoe or loss of performance in the horse. Tracheobronchoscopy, cytology of tracheobronchial aspirates, interpleural pressure measurement, and arterial blood gas analysis improved diagnosis of equine respiratory disorders. Yet some intrathoraeie diseases, especially chronic pneumonia, are differential diagnosis problems. Radiography of the thorax improves the diagnosis of pneumonia and some other intrathoraeie diseases. The technique of the radiography of the thorax is described and radiographic findings in 166 horses suffering from respiratory diseases are evaluated. Theses horses showed pathologic radiographic findings caused by COPD (n =61), pneumonia (67), pleuritis (12), exercise-induced pulmonary haemorrhage (8), aspiration pneumonia (7), hydrothorax (6), pneumothorax (2), lung abseess (1); mediastinal tumor (1), and diaphragmatie hernia (1) [German] Die chronisch obstruktive Bronchitis (COB) ist die häufigste Ursache von Atembeschwerden oder Leistungsmangel beim Pferd. Tracheobronchoskopie, Tracheobronchialsekretzytologie, interpleurale Druckmessung und arterielle Blutgasanalyse verbesserten die Diagnostik respiratorischer Erkrankungen. Dennoch bestehen Probleme hinsichtlich der Differentialdiagnose zur COB, und zwar insbesondere bei chronischen Pneumonien. Die röntgenologische Thoraxuntersuchung verbessert die Diagnose von Pneumonien und einigen anderen intrathorakalen Erkrankungen. Die Technik der röntgenologischen Thoraxuntersuchung wird beschrieben, und die Befunde von 166 Pferden mit Erkrankungen der Atemorgane werden ausgewertet. Diese Pferde zeigten pathologische Röntgenbefunde als Folge einer COB (n =61), einer Pneumonie (67), einer Pleuritis (12), eines belastungsinduzierten Lungenblutens (8), einer Aspirationspneumonie (7), eines Hydrothorax (6), eines Pneumothorax (2), eines Lungenabszesses (1), eines mediastinalen Tumors (1) und einer Zwerchfellhernie (1)

  8. The new radiation protection law 2018 and its significance for radiography; Das neue Strahlenschutzrecht 2018 und seine Bedeutung fuer die Radiographie

    Energy Technology Data Exchange (ETDEWEB)

    Kaps, Charlotte; Soelter, Barbara; Steege, Andreas [Deutsche Gesellschaft fuer Zerstoerungsfreie Pruefung e.V., Berlin (Germany)

    2017-08-01

    The European Directive 2013/59 / Euratom (Euratom Directive) requires the Federal Government, pursuant to Article 106 of this Directive, to transpose the content of the directive into national law by 6 February 2018. The aim of the Federal Ministry for the Environment, Nature Conservation, Construction and Reactor Safety (BMUB) is, in addition to the implementation of the directive, to simultaneously make use of the possibility to modernize, improve and make more effective the radiation protection law. Directive 2013/59 / EURATOM will be incorporated into German law by the new Radiological Protection Act (StrlSchG) and other regulations on the level of an ordinance. The Radiological Protection Act, the Radiation Protection Ordinance and the X-ray Ordinance will be replaced by the StrlSchG. It is interesting to see the year 2017 under the point of view that the regulations at the level of regulation need to be elaborated. In particular, since the separation in radiation protection and X-ray regulation is not continued. Users could also experience this time pressure in 2018 when, in addition to the Radiation Protection Act, a large number of ordinances become legally binding. [German] Durch die europaeische Richtlinie 2013/59/EURATOM (Euratom-Richtlinie) ist die Bundesregierung gemaess Artikel 106 dieser Richtlinie verpflichtet, die inhaltlichen Vorgaben bis 6. Februar 2018 in nationales Recht umzusetzen. Das Ziel des Bundesministeriums fuer Umwelt, Naturschutz, Bau und Reaktorsicherheit (BMUB) ist es, neben der Umsetzung der Richtlinie, gleichzeitig die Moeglichkeit zu nutzen, das Strahlenschutzrecht zu modernisieren, praxistauglich zu verbessern und vollzugsfreundlicher zu gestalten. Die Richtlinie 2013/59/EURATOM wird durch das neue Strahlenschutzgesetz (StrlSchG) und weiteren Regelungen auf Verordnungsebene in das deutsche Recht eingehen. Das Strahlenschutzvorsorgegesetz, die Strahlenschutzverordnung und die Roentgenverordnung werden vom StrlSchG abgeloest werden. Interessant wird das Jahr 2017 unter dem Blickwinkel, dass die Regelungen auf Verordnungsebene erst noch erarbeitet werden muessen. Insbesondere, da die Trennung in Strahlenschutz- und Roentgenverordnung nicht fortgefuehrt wird. Auch die Anwender koennten diesen zeitlichen Druck 2018 zu spueren bekommen, wenn neben dem Strahlenschutzgesetz, noch eine Vielzahl an Verordnungen rechtskraeftig werden.

  9. The significance of microRNAs or the cellular response in endothelium cells; Die Bedeutung von microRNAs fuer die zellulaere Strahlenantwort in Endothelzellen

    Energy Technology Data Exchange (ETDEWEB)

    Moertl, Simone; Heider, Theresa [Helmholtz Center Muenchen, Neuherberg (Germany). Arbeitsgruppe Clinical Radiation Biology

    2016-08-01

    Ionizing radiation causes a variety of cell damages. Several cell constituents like DNA, mitochondria, proteins or membranes are affected. Cells have developed numerous and cross-linked radiation response processes for counteraction. In case of failure of the repair mechanism cell proliferation or cell death are the consequences. Many proteins in these processes are controlled by microRNAs (miRNAs). The accurate knowledge of miRNA functions is therefore importance not only for radiation protection but also the therapeutic use of ionizing radiations.

  10. On the significance of natural gas with regard to tomorrow's customer target group; Zur Bedeutung von Erdgas in der Kundenzielgruppe von morgen

    Energy Technology Data Exchange (ETDEWEB)

    Halstrup, Dominik [Hochschule Osnabrueck (Germany). Professur fuer BWL und Strategisches Management; Groeblinghoff, Sebastian [EVU, Essen (Germany); Walsh, Gianfranco [Koblenz Univ. (Germany). Inst. fuer Management

    2011-10-15

    Competition between the energy carriers in Germany's heating market has become harsher over the past years and is expected to grow still further. Successful customer acquisition and long-term customer retention will become increasingly important for natural gas supply companies. For this reason decision makers at public utilities that have a significant share of natural gas in their sales portfolio should have the foresight to ask themselves what sentiment tomorrow's home and house owners will have towards natural gas as an energy product as well as towards their company.

  11. Die regionalökonomische Bedeutung der Wissenschaft für das Ruhrgebiet. Hochschulen und außeruniversitäre Forschungseinrichtungen als Motor der regionalen Entwicklung

    Science.gov (United States)

    Kriegesmann, Bernd; Böttcher, Matthias; Lippmann, Torben

    2016-09-01

    The Ruhr area has advanced to the largest university region in Germany - often unnoticed within and outside. At the same time scientific institutions have become a major economic factor. Because of the higher and extra-university research institutions about 2.5 billion euros are effective as a demand potential in the region. 1.7 billion euros of this amount are directly associated with investments and operating expenditures of the scientific institutions as well as consumptions of employees and students. Additional 770 million euros result in revenues of many branches such as trade, housing, gastronomy sector, handcraft industry etc. It should not be underestimated that higher and extra-university research institutions generate with their research activities particular funding from the European Union or the rest of Germany for benefit of the region. Each euro spent by the state government for basic funding creates 39 cents third-party funding. These regional-economic effects result in noticeable employment impacts within the region. Around 25,000 people are directly employed in higher and extra-university research institutes or student unions (Studierendenwerke), about 22,000 jobs in other economic sectors are ensured or created by the induced demand. Science has thus become an important economic factor and represents an essential counterbalance to employment decline in shrinking industries of the region. The specific inclusion of science in a regional development strategy and targeted relining with appropriate measures to strengthen the science creates therefore an effective starting point for the design of structural change.

  12. Natural radionuclides in urine and feces samples and their importance for incorporation monitoring; Natuerliche Radionuklide in Urin- und Stuhlproben und deren Bedeutung in der Inkorporationsueberwachung

    Energy Technology Data Exchange (ETDEWEB)

    Froning, Martina; Burow, Mechthild; Droop, Philipp; Laumen-Sentis, Sandra; Zoriy, Myroslav [Forschungszentrum Juelich GmbH (Germany)

    2017-08-01

    Incorporation monitoring is performed for personnel dealing with open radioactive materials if incorporation cannot be excluded. Besides occupational exposure everybody is exposed to natural radioactivity. For the interpretation of occupational incorporation or in case of a radiation accident it is necessary to know the diet related share of natural radioactivity.

  13. Neue molekulare Mechanismen zellulärer Interaktionen an der Gefäßwand und ihre Bedeutung für die Pathogenese der Atherosklerose

    OpenAIRE

    Borst, Oliver Alexander

    2010-01-01

    Hintergrund: EMMPRIN (Extracellular matrix metalloproteinase Inducer) ist ein immunglobulinähnliches Glykoprotein, das auf verschiedenen Zellen exprimiert wird. Erstmals beschrieben wurde EMMPRIN auf Tumorzellen. Zwischenzeitlich ist bekannt, dass EMMPRIN auch auf verschiedenen weiteren Zellen (z.B. auf Fibroblasten, Monozyten oder glatten Muskelzellen) exprimiert wird. Erst vor kurzem konnte eine aktivierungsabhängige Expression von EMMPRIN nun auch auf Thrombozyten nachgewiesen w...

  14. Clinical importance and significance of early evaluation of therapy response in lung cancer; Klinische Notwendigkeit und Bedeutung der Frueherfassung der Therapie-Response beim Bronchialkarzinom

    Energy Technology Data Exchange (ETDEWEB)

    Griesinger, F. [Universitaetsklinik Goettingen (Germany). Abt. Haematologie und Onkologie; Baum, R.P. [Zentralklinik Bad Berka (Germany). Klinik fuer Nuklearmedizin/PET-Zentrum

    2001-04-01

    In solid tumors, especially in non-small cell lung cancer (NSCLC), the TNM staging is the only well defined pretherapeutic risk factor. TNM-staging has a significant impact on prognosis and survival and is used to determine therapeutic stratification. Although numerous molecular and immunologic pretherapeutic risk factors have been described in NSCLC, none of them has been translated into therapeutic stratification. Therefore, the identification of posttherapeutic risk factors in NSCLC is essential. Locally advanced NSCLC are currently treated with preoperative (neoadjuvant) induction regimens. It has been shown that systemic tumor control and long-term disease free survival is correlated with histologic tumor regression. First results are presented in this paper that PET may be highly predictive for histologic tumor regression and long term outcome in NSCLC stage III. These results may establish PET as the first noninvasive posttherapeutic risk factor in locally advanced NSCLC. (orig.) [German] Bei soliden Tumoren, insbesondere beim nichtkleinzelligen Bronchialkarzinom (NSCLC), sind praetherapeutische Risikofaktoren im Westlichen durch das Tumorstadium (TNM-Klassifikation) definiert. Diese Tumorstadien haben eine erhebliche prognostische Relevanz und sind entscheidend fuer die Therapiestratifikation. Obwohl eine Reihe praetherapeutischer molekularer und immunologischer Risikofaktoren beim NSCLC beschrieben wurden, hat keiner von ihnen Eingang in die prospektive Risikostratifikation oder Therapieplanung gefunden. Daher ist die Identifikation posttherapeutischer Risikofaktoren zur Therapiestratifikation des NSCLC essenziell wichtig. Ein innovativer Therapieansatz bei lokal fortgeschrittenen NSCLC ist die neoadjuvante (praeoperative) Induktionstherapie. Hier konnte gezeigt werden, dass die systemische Tumorkontrolle und das Langzeitueberleben mit dem histologischen Ansprechen korrelierte. Erste Untersuchungen zeigen jetzt, dass die FDG-PET vermutlich einen hohen praediktiven Wert in der Vorhersage der Tumorregression und damit fuer die Langzeitprognose hat, wodurch sich die Perspektive eroeffnet, PET als neue, nichtinvasive posttherapeutische Untersuchung zur Risikostratifikation beim lokal fortgeschrittenen nichtkleinzelligen Bronchialkarzinom zu etablieren. (orig.)

  15. Die Bedeutung Subjektiver Elternschaftskonzepte fur Erziehungsverhalten und elterliche Partnerschaft. Ein Uberblick uber neuere Forschungsergebnisse (The Significance of Subjective Concepts of Parenthood for Educational Behavior and Parental Partnership).

    Science.gov (United States)

    Kalicki, Bernhard

    2003-01-01

    Outlines the subjective concept of parenthood as the personal interpretation of parental responsibility, distinguishing it from related theoretical concepts. Discusses, against the background of theoretical models and empirical findings, the relationship of the parenthood concept with the parents' actual educational behavior. Suggests ways to…

  16. Was ein Wort bedeutet, kann ein Satz nicht sagen: Zur Bedeutung der Terminologiearbeit für die Technische Kommunikation und das Fachtextübersetzen

    Directory of Open Access Journals (Sweden)

    Klaus-Dirk Schmitz

    2010-05-01

    Full Text Available Einleitung: Dieser Beitrag geht von einem Zitat des österreichisch-britischen Philosophen Ludwig Wittgenstein aus und bezeiht sich auf seine Aussagen über Wörter und Sätze. Zielsetzung: Analyse und Diskussion der Relevanz von WittgensteinsAussage für die Terminologiearbeit in der Technischen Kommunikation und beim Fachübersetzen. Methode: Kritische Analyse und Betrachtung. Ergebnis: Neben den terminologischen Grundbegriffen Begriff, Benennung und Gegenstand werden vor allem die Definition als Begriffsbeschreibung sowie die Kriterien zur Bildung von Benennungen untersucht. Schlussfolgerung: Das Zitat von Wittgenstein lässt viele Interpretationen zu. Für die Technische Kommunikation und das Fachübersetzen muss aber die Definition (Satz den Begriff hinter der Benennung (Wort erklären. Idealerweise ist aber die Benennung so transparent, dass dadurch schon die Begriffsklärung erfolgt.

  17. Die Bedeutung des Habitus-Konzepts für die Erforschung soziokultureller Unterschiede im Bereich der Medienpädagogik

    Directory of Open Access Journals (Sweden)

    Ralf Biermann

    2009-08-01

    Full Text Available In diesem Artikel geht es um die nähere Betrachtung, welche grundlegenden Schnittstellen sich zwischen medienpädagogischen Ansätzen und der Habitus- Theorie von Pierre Bourdieu ergeben. Basierend auf diesen Überlegungen werden Aspekte ausgearbeitet, die in medienpädagogischer Forschung und Praxis zur Beachtung soziokultureller Unterschiede Berücksichtigung finden können.

  18. Parameters of leisure mobility of elder people: The importance of settlement structures and automobile availability; Bestimmungsgroessen der Freizeitmobilitaet aelterer Menschen: Die Bedeutung von Siedlungsstrukturen und Pkw-Verfuegbarkeit

    Energy Technology Data Exchange (ETDEWEB)

    Scheiner, J. [Dortmund Univ. (Germany). Fakultaet Raumplanung, Verkehrswesen und Verkehrsplanung

    2005-07-01

    According to gerontological mobility research, car availability as well as appropriate settlement structures at the neighbourhood level are both playing a prominent role in the maintenance of mobility of elderly people. However, car availability is strongly connected to other individual attributes like age, health and gender. The paper investigates whether car availability and spatial context have an impact on leisure mobility of elderly people when socio-demographic and health factors are being controlled for. The paper is based on a standardised cross-sectional survey among n=4,500 residents of three different study areas in Germany. Leisure mobility was investigated with respect to out-of-home activity frequency, activity diversity, travel distance, existence of unfulfilled activity wishes, and leisure satisfaction. According to the results, leisure mobility is strongly associated with health, social networks, and socio-demographic characteristics. Only two mobility measures are positively associated with the availability of a private car. The spatial context does not have a significant influence on any mobility indicator. The results support the thesis that car availability is not a cause for mobility, but rather a result of a specific life situation, which is associated with a specific type of mobility. (orig.)

  19. Transport of sediments in Himalaya-Karakorum and its influence on hydropower plants; Sedimenttransportprozesse im Himalaya-Karakorum und ihre Bedeutung fuer Wasserkraftanlagen

    Energy Technology Data Exchange (ETDEWEB)

    Palt, S.M.

    2001-07-01

    In the present study the sediment transport processes in alpine mountain areas and their impact on hydropower development projects are investigated. The aim of the present work is to contribute to the understanding of the transport process system, which is characterized by high magnitude-low frequency - events, to ensure an appropriate layout of high head hydropower projects in mountain regions. The sediment transport in large areas in the macro scale is triggered by natural hazards, such as earthquakes, rock slides, earth movements, debris flows, glacial lake outbursts and floods. The basic principle of complex transport processes in this scale is described and explained on the example of the Himalaya-Karakorum-region. The sediment transport process in the smaller scale, so called meso scale, is investigated by means of extensive field measurements at river reaches of 16 different mountain rivers of a 80000 km{sup 2} large project area. The measurements include topographic survey works and measurements of discharge, bed load and suspended load. Since the conditions of mountain rivers in terms of size of bed material as well as available flow velocities can be considered as extreme, an appropriate bed load sampler named B-69 was developed, constructed and used in the field. Moreover the hydraulic as well as the sedimentological efficiency of the sampler was tested in the laboratory tests. Due to the nice performance of the bed load sampler B-69 at high flow velocities it might be useful for flood conditions in gravel-bed rivers in other parts of the world as well. Based on the results of the study the parameter of the river slope can be considered as the most important one for the characteristics of the morphology, the flow conditions, the bed stability as well as the bed load transport in steep mountain rivers. With increasing slope morphological structures in the longitudinal direction will develop from flat bed conditions. The so called step-pool-systems consist of a cascade of staircase local falls. Their distance in-between the falls as well as their height difference at the steps is strongly depending on the river slope. (orig.) [German] Die vorliegende Arbeit beschaeftigt sich mit den Sedimenttransportprozessen in alpinen Gebirgsregionen und deren Auswirkungen auf Wasserkraftanlagen. Ziel der Arbeit ist es, zum Verstaendnis des natuerlichen Sedimenttransportes mit der fuer Gebirgsregionen typischen Charakteristik von 'High Magnitude-Low Frequency - Prozessen' beizutragen, um eine den Transportverhaeltnissen geeignete Auslegung von geplanten Wasserkraftanlagen zu finden. Am Beispiel der Gebirgsregion des Himalaya-Karakorums werden die komplexen Transportvorgaenge im grossraeumigen Raum des Makromassstabes erlaeutert. Dabei wird auf die Massentransporte eingegangen, die durch Naturgefahren wie Erdbeben, Felsgleitungen, Erdrutsche, Muren, Gletscherbrueche und Hochwaesser ausgeloest werden. Der Schwerpunkt der Arbeit liegt in der Durchfuehrung von umfangreichen Naturmessungen im untergeordneten Raum des Mesomassstabes im Bereich von einzelnen Flussabschnitten. Die Naturmessungen umfassen morphologische und topographische Aufnahmen, Abfliessmessungen, Geschiebe- sowie Schwebstoffmessungen an 16 Gebirgsfluessen eines insgesamt 80000 km{sup 2} grossen Projektgebietes im Himalaya-Karakorum. Aufgrund der extremen Verhaeltnisse der Gebirgsfluesse der Region hinsichtlich vorhandener Korngroesse des Bettmaterials sowie die Groessenordnung der Fliessgeschwindigkeiten wurde fuer die Untersuchungen eigens der mobile Geschiebesammler B-69 entwickelt, gebaut und auf seine hydraulische und sedimentologische Effizienz hin geprueft. Der Einsatz des B-69 hat sich im Feld bewaehrt und ist fuer weitere Anwendungen bei Hochwasserereignissen in kiesfuehrenden Fluessen geeignet. Als massgebender Parameter zur Beschreibung der Morphologie, der Stroemung, der Sohlenstabilitaet und des Geschiebetransportes von Gebirgsfluessen im Mesomassstab konnte das Gefaelle I festgestellt werden. Das Gefaelle ist bestimmend fuer die Ausbildung der morphologischen Strukturen im Laengsprofil, die sich mit zunehmendem Gefaelle von der ebenen Sohle (I<1%) als eine Sequenz von lokalen Abstuerzen, auch als Step-Pool-Systeme bezeichnet, ausbildet. Je steiler die Neigung des Gerinnes desto geringer wird der Abstand der Step-Pools in Laengsrichtung und desto groesser wird der Hoehenunterschied an der einzelnen Struktur. (orig.)

  20. Significance of CT analysis of regional lymph node metastases in colorectal cancer; Bedeutung der CT fuer die Beurteilung regionaerer Lymphknotenmetastasen bei kolorektalen Karzinomen

    Energy Technology Data Exchange (ETDEWEB)

    Gomille, T.; Christ, F. [Duesseldorf Univ. (Germany). Abt. fuer Radiologie und Nuklearmedizin; Aleksic, M.; Ulrich, B. [Krankenhaus Gerresheim (Germany). Chirurgische Klinik

    1998-12-01

    Purpose: For preoperative staging of colorectal cancer a CT scan is frequently performed. This report examines the sensitivity of CT for regional lymph node metastasis of colorectal cancer using different criteria. Materials and methods: Preoperative CT scans of 153 patients with colorectal cancer were analyzed using different criteria for N1. The results were then compared to the postoperative histological findings. Results: For N1=lymph nodes (LN)>1 cm the sensitivity was 47%. For N1=LN>1 cm or an increased number of LN<1 cm the sensitivity was 71%. In patients with a primary tumor seen on CT, sensitivity rose to 87%. Discussion: Evidence of regional nodal metastatic disease is only relevant for rectal cancer, colon polyps, and for locally excised tumors when considering present surgical concepts for the treatment of colorectal cancer. In these cases CT analysis using the broadened criteria for N1 proposes a valuable argument regarding possible preoperative radiotherapy or an operative revision. (orig.) [Deutsch] Die Sensitivitaet fuer den Nachweis regionaerer Lymphknotenmetastasen kolorektaler Karzinome wurde unter Anwendung verschiedener Kriterien fuer das N1-Stadium an Patienten mit histologisch gesichertem Lymphknotenbefund untersucht. Fuer das Kriterium N1=Lymphknoten (LK)>1 cm betrug die Sensitivitaet 47%. Fuer N1=LK>1 cm/vermehrte Anzahl LK<1 cm war sie 71%, bei erkennbarem Primaertumor sogar 87%. Unter Beruecksichtigung der derzeit geltenden operativen Therapiekonzepte ist der Nachweis von regionaeren Lymphknotenmetastasen nur bei Rektumkarzinom bzw. fuer Kolonpolypen oder fuer lokal exzidierte Karzinome fuer das therapeutische Vorgehen relevant. In diesen Faellen leistet die CT mit den erweiterten Kriterien fuer ein N1-Stadium trotz hoeherer falsch-positiver Raten eine wertvolle Hilfestellung fuer die Entscheidung ueber eine neoadjuvante Bestrahlung oder eine Nachresektion. (orig.)

  1. Clinical value of the esophageal scintigraphy in multi-swallow technique comparing to esophageal manometry; Bedeutung der parametrisierten Oesophagusszintigraphie in Mehrfachschlucktechnik im Vergleich zur Oesophagusmanometrie

    Energy Technology Data Exchange (ETDEWEB)

    Eising, E.G. [Klinik und Poliklinik fuer Nuklearmedizin, Univ. Essen (Germany); Holtmann, G. [Abt. fuer Gastroenterologie, Medizinische Klinik, Univ. Essen (Germany); Reiners, C. [Klinik und Poliklinik fuer Nuklearmedizin, Univ. Essen (Germany)

    1996-06-01

    Diagnosis of esophageal motility disorders is difficult due to the large physiologic variability of bolus transport. With the help of a parametric multiple swallow technique (introduced by Tatsch), using `condensed images` of each single sallow action before creating a `mean image` of six swallows, this problem can be solved. For testing this relatively new method, 12 patients underwent 16 pairs of parametric esophagel scintigraphy and esophageal manometry. This collective of patients consisted of 4 with achalasia and secondary hypomobility of the tubular esophagus, 7 with unspecific esophageal dysfunction confirmed by manometry and 1 with clinical dysphagia and normal status in manometry. Fourteen of 15 pathological manometric findings could be confirmed with parametric scintigraphy. Esophageal monometry was false negative in one case and esophageal scintigraphy in another one case. The calculated emptying rates 10 and 12 s after beginning of swallowing are (mean{+-}SD) 56{+-}34% and 60{+-}34% respectively for solid meal and 54{+-}25% 57{+-}22% respectively for liquid meal. Of 60 emptying rates, 48 are in the pathologic range of less than 80%. As expected, no significant difference was found between emptying rates after 10 and 12 s (two-tailed matched pairs t-test, 5% significance level). In conclusion, parametric esophageal multiple swallow scintigraphy has been proven to be a non-invasive and sensitive tool for pre- and posttherapeutic care of patients with esophageal motility disorders. It should be mentioned that esophageal scintigraphy can give additional information in some cases of normal esophageal manometry. (orig.) [Deutsch] Die parametrisierte Oesophagusszintigraphie in Mehrfachschlucktechnik nach Tatsch (unter Verwendung sog. kondensierter Einzelschluckbilder und einem daraus errechneten Summationsbild) laesst eine sichere Erfassung pathologischer oesophagealer Motilitaetsstoerungen trotz der hohen physiologischen Variabilitaet des Schluckaktes erhoffen. Zur Ueberpruefung dieser relativ neuen Methode wurden die Befunde der invasiven, jedoch gut standardisierten Oesophagusmanometrie mit dieser Form der Oesophagusszintigraphie verglichen. Untersucht wurden 12 Patienten 16mal mittels Manometrie und Szintigraphie (davon 4 Patienten mit Achalasie und sekundaerer Hypomotilitaet im turbulaeren Oesophagus, 7 Patienten mit unspezifischen, monometrisch nachgewiesenen Motilitaetsstoerungen und 1 Patient mit Dysphagie und unauffaelliger Manometrie). 14 der 15 manometrisch pathologischen Untersuchungen konnten szintigraphisch bestaetigt werden. Falsch negativ fielen die Manometrie und die Szintigraphie in jeweils einem Fall aus. Die ermittelten prozentualen Werte fuer die szintigraphischen Entleerungssraten nach 10 bzw. 12 s (jeweils Mittelw. {+-}Standardabw.) betrugen fuer feste Kost 56{+-}34 bzw. 60{+-}34 Prozent und fuer fluessige Kost 54{+-}25 bzw. 57{+-}22 Prozent. 48 der 60 szintigraphisch gemessenen Entleerungsraten erschienen mit unter 80% pathologisch. Erwartungsgemaess ergab sich kein signifikanter Unterschied zwischen den szintigraphischen 10 s- und 12 s-Entleerungsraten (t-Test fuer gepaarte Stichproben, 5%-Signifkanzniveau, zweiseitige Testung). Zusammenfassend erscheint das vorgestellt szintigraphische Verfahren nicht invasiv und sensitiv zur Erfassung und posttherapeutischen Verlaufskontrolle oesophagealer Motilitaetsstoerungen und kann im Einzelfall sogar ueber die manometrischen Ergebnisse hinausgehende Informationen liefern. (orig.)

  2. Implications of the Pressurized Equipment Directive of the EC for the German gas trade and industry; Die Bedeutung der EG-Druckgeraeterichtlinie fuer das deutsche Gasfach

    Energy Technology Data Exchange (ETDEWEB)

    Jannemann, T.B. [DVGW Deutsche Vereinigung des Gas- und Wasserfaches e.V., Bonn (Germany)

    2003-06-01

    The standards and requirements to be met by the equipment, components and materials manufactured and used in Germany are specified in the DVGW code, of which some parts and content will need amending and adjustment to the EC Pressurized Equipment Directive. The aim of this harmonization is to remove technical barriers to trade within the European Union. (orig./CB) [German] Die konkreten Anforderungen an Geraete, Bauteile und Materialien sind im DVGW-Regelwerk festgeschrieben. Im Rahmen der Realisierung des EU-Binnenmarktes wird das DVGW-Regelwerk teilweise europaeisch harmonisiert. Ziel ist die Beseitigung technischer Handelshemmnisse unter gleichzeitiger Beruecksichtigung des europaeisch relevanten Schutzniveaus. (orig.)

  3. Criminal implication of sponsoring in medicine: legal ramifactions and recommendations; Strafrechtliche Bedeutung des Sponsorings in der Medizin: Gesetzliche Rahmenbedingungen und Handlungsempfehlungen

    Energy Technology Data Exchange (ETDEWEB)

    Mahnken, A.H.; Guenther, R.W. [Klinik fuer Radiologische Diagnostik, Universitaetsklinikum Aachen (Germany); Theilmann, M. [Rechtsanwalt Martin Theilmann, Osnabrueck (Germany); Bolenz, M. [Fakultaet Wirtschafts- und Sozialwissenschaften, Fachhochschule Osnabrueck (Germany)

    2005-08-01

    As a consequence of the so-called ''Heart-Valve-Affair'' in 1994, the German public became aware of the potential criminal significance of industrial sponsoring and third-party financial support in medicine. Since 1997, when the German Anti-Corruption Law came into effect, the penal regulations regarding bribery and benefits for public officers were tightened. Due to the lack of explicit and generally accepted guidelines in combination with regional differences of jurisdiction, there is a lingering uncertainty regarding the criminal aspects of third-party funding and industrial sponsoring. The aim of this review is to summarize the penal and professional implications of third-party funding and sponsoring in medicine including recent aspects of jurisdiction. The currently available recommendations on this issue are introduced. (orig.)

  4. Prothèses péniennes : taille du pénis implanté et dimensions de la virilité

    OpenAIRE

    Kempeneers, Philippe; Andrianne, Robert; Mormont, Christian; Jeanmart, Fabian; Blochousse, Laurence

    2001-01-01

    The implantation of a penile prosthesis frequently results in a reduction of the erectile length compared with natural erections. Some patients complain about this fact and their satisfaction at prosthesis assisted sexuality is significantly diminished. Obviously, the degree of complaint is not proportional to the objective degree of penile reduction. For an objective reality to lead to complaints, subjective criteria of appreciation have to intervene. A survey questionnaire completed ...

  5. Impact of Gender-Specific Human Papillomavirus Vaccine Recommendations on Uptake of Other Adolescent Vaccines: Analysis of the NIS-Teen (2008-2012).

    Science.gov (United States)

    Bednarczyk, Robert A; Orenstein, Walter A; Omer, Saad B

    In the United States, human papillomavirus vaccination was routinely recommended for adolescent females in 2006 and provisionally recommended for adolescent males in 2009. We evaluated the hypothesis that gender-specific human papillomavirus vaccination recommendations would impact gender-specific uptake of other vaccines using National Immunization Survey-Teen public use data sets (2008-2012). Female adolescents had higher coverage than males of at least 1 other adolescent vaccine in 2008 (3.0% higher) and 2009 (4.3% higher). Gender differences abated in 2010, 2011, and 2012 (0.2%, 0.9%, and 0.4%, respectively). To evaluate unintended consequences of gender-based recommendations, countries with female-only human papillomavirus vaccination recommendations should evaluate gender-specific uptake of other adolescent vaccines.

  6. Plasma Levels of Advanced Glycation Endproducts N-is an element of-(carboxymethyl)lysine, N-is an element of-(carboxyethyl)lysine, and Pentosidine Are not Independently Associated With Cardiovascular Disease in Individuals With or Without Type 2 Diabetes: The Hoorn and CODAM Studies

    NARCIS (Netherlands)

    Hanssen, N.M.J.; Engelen, L.; Ferreira, I.; Scheijen, J.L.J.M.; Huijberts, M.S.; van Greevenbroek, M.M.J.; van der Kallen, C.J.H.; Dekker, J.M.; Nijpels, G.; Stehouwer, C.D.A.; Schalkwijk, C.G.

    2013-01-01

    Objective: Experimental and histological data suggest a role for advanced glycation end products (AGEs) in cardiovascular disease (CVD), particularly in type 2 diabetes (T2DM). However, the epidemiological evidence of an adverse association between AGEs and CVD remains inconclusive. We therefore

  7. Prognostische Bedeutung der Expression der P2RY8-CRLF2-Fusions-assoziierten Gene LRRC32, BMP6 und VPREB1 für die Akute Lymphoblastische Leukämie im Kindes- und Jugendalter

    OpenAIRE

    Buchmann, Swantje

    2017-01-01

    Die Optimierung der Therapie der kindlichen ALL kann möglicherweise durch die Identifikation neuer molekularer Marker geschehen, die diejenigen Patienten schon zum Diagnosezeitpunkt oder während der initialen Therapie als Hochrisikopatienten charakterisieren, die noch nicht als solche gelten, aber mit einer hohen Wahrscheinlichkeit ein Rezidiv erleiden werden. Im Rahmen der ALL BFM 2000-Studie konnte gezeigt werden, dass in einer Subgruppe der pB-ALL die Existenz der P2RY8-CRLF2-Fusion mit...

  8. S3 Guideline. Diagnosis and treatment of colorectal carcinoma. Relevance for radiologic imaging and interventions; Aktualisierte S3-Leitlinie zur Diagnostik und Therapie des kolorektalen Karzinoms. Bedeutung fuer die radiologische Diagnostik und Intervention

    Energy Technology Data Exchange (ETDEWEB)

    Vogl, T.J.; Fischer, S. [Universitaetsklinikum Frankfurt (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie; Schmiegel, W.; Pox, C. [Bochum Univ. (Germany). Medizinische Universitaetsklinik; Pereira, P.L. [SLK Kliniken, Heilbronn (Germany). Klinik fuer Radiologie, Minimal-Invasive Therapien und Nuklearmedizin; Brambs, H.J. [Universitaetsklinikum Ulm (Germany). Klinik fuer Diagnostische und Interventionelle Radiologie; Lux, P. [Universitaetsklinikum Erlangen (Germany). Chirurgische Klinik

    2013-08-15

    The new German S3 guideline 'Colorectal Carcinoma' was created as part of the German Guideline Program in Oncology of the Association of the Scientific Medical Societies in Germany, the German Cancer Society and the German Cancer Aid under the auspices of the German Society for Digestive and Metabolic Diseases and replaces the guideline from 2008. With its evidence-based treatment recommendations, the guideline contains numerous updates and detailed definitions regarding the diagnosis and treatment of colon and rectal cancer. In particular, consensus-based recommendations regarding early detection, preoperative diagnostic method selection, and the use of interventional radiological treatment methods are detailed. The guideline also includes quality indicators so that standardized quality assurance methods can be used to optimize patient-related processes. The present article discusses the significance of the current recommendations for radiological diagnosis and treatment and is intended to enhance the quality of patient information and care by increasing distribution. (orig.)

  9. Präzisionsmessungen an Myondriftkammern für den CMS-Detektor und die Bedeutung des Myonsystems für die Higgs-Suche am LHC

    CERN Document Server

    Hermann, Sven

    2004-01-01

    This thesis deals with preparations for the experiment CMS (Compact Muon Solenoid) of the LHC (Large Hadron Collider) planned at CERN in Geneva (Switzerland). The construction of the muon system, especially of the drift chambers in the barrel detector constructed with participation of the Aachen group, is explained. In the first part of the thesis the results from a Monte-Carlo-study for a decay channel interesting for the search for the Higgs boson at CMS is presented. In this channel the Higgs finally decays into four muons. The second part describes the running production of the drift chambers as well as results of tests developed and implemented for purposes of quality control. The LHC will accelerate protons to a center of mass energy of 14 TeV, aspiring to a luminosity of L = 10^34 cm^-2s^-1, allowing for the production of a sufficient number of such processes as rare as the production of Higgs bosons, which were predicted, but not yet proven. The Higgs bosons, created mainly by gluon gluon fusion in pr...

  10. Chimäre Mensch?: die Bedeutung der menschlichen Natur in Zeiten der Xenotransplantation = Chimeric human?: the importance of human nature in times of xenotransplantation = Quimera humana?: importância da natureza humana em tempos de xenotransplantes

    Directory of Open Access Journals (Sweden)

    Vieth, Andreas

    2013-01-01

    Full Text Available O artigo reexamina a questão dos xenotransplantes (transplantes de órgãos entre diferentes espécies, tecendo várias observações sobre as práticas de xenotransplantes com o intuito de determinar com precisão o que se entende por “xenotransplante” (XTP e de esclarecer em que medida um transplante de animais no organismo humano pode ser denominado uma “quimera”. Em seguida, os aspectos problemáticos do XTP, desde uma perspectiva ética, embora não sejam abordados no artigo, são nomeados em sua relevância teórica para o conceito de justificação, num sentido ético-normativo. Esclarecimentos conceituais e terminológicos preliminares são oferecidos pelos Autores a fim de deixar claro o que se entende, afinal, por “natureza”, tanto num sentido restrito quanto em sua relevância para as discussões éticas. O atual debate em torno de questões normativas e naturalistas da natureza e da ética é revisado em vários aspectos, culminando numa alternativa sistemática a ser desenvolvida e proposta

  11. Chimäre Mensch?: die Bedeutung der menschlichen Natur in Zeiten der Xenotransplantation = Chimeric human?: the importance of human nature in times of xenotransplantation = Quimera humana?: importância da natureza humana em tempos de xenotransplantes

    OpenAIRE

    Vieth, Andreas; Quante, Michael

    2013-01-01

    O artigo reexamina a questão dos xenotransplantes (transplantes de órgãos entre diferentes espécies), tecendo várias observações sobre as práticas de xenotransplantes com o intuito de determinar com precisão o que se entende por xenotransplante (XTP) e de esclarecer em que medida um transplante de animais no organismo humano pode ser denominado uma quimera. Em seguida, os aspectos problemáticos do XTP, desde uma perspectiva ética, embora não sejam abordados no artigo, são nomeados em sua rele...

  12. State of the art and perspectives of the cultivation of energy crops in Hesse. Significance, procedure of cultivation, sustainability; Stand und Perspektiven des Energiepflanzenanbaus in Hessen. Bedeutung, Anbauverfahren, Nachhaltigkeit

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-15

    In line with the further increase in the use of renewable energy sources, the expansion of biomass utilization in Hesse increasingly becomes important. In light of the increasing criticism of the cultivation of energy crops, it is important to learn about the situation in the Federal State Hessen (Federal Republic of Germany). Under this aspect, the booklet under consideration contributes to proper information and creating acceptance in the current discussion on the development of bioenergy in Hessen. In particular, the brochure reports on the following topics: (1) What is the advantage of the bioenergy in Hessen?; (2) Scope of the cultivation of energy crops in the Hessian agriculture?; (3) Economic aspects of the cultivation of energy crops for biogas plants; (4) Cultivation of oil crops for the production of biodiesel oil and vegetable oil; (5) Cultivation of cereals and sugar beet for bioethanol production; (6) One-year-old energy crops; (7) Perennial energy crops; (8) Aspects of sustainability in the cultivation of energy crops; (9) Areas of conflict in the cultivation of energy crops.

  13. The central importance of the EU emission trading scheme for achievement of the German climate protection target of 40% until 2020; Die zentrale Bedeutung des EU-Emissionshandels zur Erreichung des deutschen Klimaziels in Hoehe von 40 % bis 2020

    Energy Technology Data Exchange (ETDEWEB)

    Hermann, Hauke; Cludius, Johanna

    2014-02-15

    Both Germany and the European Union have set themselves targets for the reduction of greenhouse gas (GHG) emissions. The EU was the forerunner in 2008 when it adopted the Climate and Energy package and set a target of reducing GHG emissions by 20 % by 2020 compared to 1990. Two years later, Germany adopted a range of national GHG targets in the context of the German government's Energy Concept. This includes a 40% emissions reduction target to be met by 2020. One of the main instruments for achieving GHG emissions reduction targets is the EU Emissions Trading Scheme (EU ETS), which covers all large industrial and combustion installations in Europe. According to the agreement made in 2008 (Climate and Energy Package), the effort to achieve the EU's 20 % reduction target by 2020 was split between the ETS sector (2/3 of the reduction effort, representing a 21 % reduction in GHG emissions for installations covered under the ETS compared to 2005) and the non-ETS sector (1/3 of the reduction effort, representing a 10 % reduction compared to 2005). Logically, GHG emissions reductions occurring in German ETS installations count both towards the EU and the national target. This research project has been commissioned to analyse whether the ETS in its cur-rent design can contribute its fair share in efforts to meet the national emissions reduc-tion target. This question is particularly relevant in light of the following considerations: - The new German Coalition Agreement, signed in December 2013, reiterated the national target of a 40 % reduction of GHG emissions by 2020 compared to 1990 levels. - At the same time, the new Coalition Agreement stated that changes to the ETS are only to be considered if the EU GHG emissions reduction target will not be met. - There is a surplus of CO2 allowances on the ETS market, which undermines the credibility of the instrument as well as the integrity of the emissions reduction tar-gets (both European and national). At the same time, the ETS has faced structurally low allowance prices from 2012 on-wards because of a massive supply of EU emission allowances (EUA) and external emission reduction credits, which exceeds the demand significantly. The surplus amounted to 1.8 billion EUAs at the end of the second trading period (2008-2012), will reach approx. 2 billion EUAs in 2013 and remain at up to 2 billion EUAs until the end of the third trading period (2013-2020). This structural surplus has significant implications for the fulfilment of European and national targets. The present research project concludes that the current design of the ETS is not ambitious enough to meet the national 40% target. Germany will also not be able to reach this target if the structural reform of the ETS is not improved considerably. Without this revision, there is a gap of 10.7 % to meeting the target based on 1990 levels, meaning that Germany would achieve an emissions reduction target of 29.3% instead of 40% in 2020. A combination of three factors is responsible for this gap: - surplus allowances being carried over from the second trading period (6.2 % compared to 1990); - a relatively unambitious reduction factor throughout the third trading phase compared to what should be achieved in the ETS sectors under the 40% national target (3 % compared to 1990); - a lack of ambition in the sectors not covered by the EU ETS compared to what should be achieved in the non-ETS sectors under the 40% national target (1.5 % compared to 1990). To meet the 40 % target in Germany, structural measures for reforming the EU ETS are necessary before 2020. Between 1.8 and 2.3 billion EU emission allowances (EUAs) have to be taken off the market in the long term (long-term set-aside) to remove current surpluses (1.8 billion EUAs) and to compensate for the expected imports of external emission reduction credits (0.5 billion CERs and ERUs) allowed to enter the market before 2020. Furthermore, the linear reduction factor needs to be tightened from the current 1.74 % to 2.9 % from 2014 onwards. The structural reform of the EU ETS that has been proposed by the EU Commission (creating a ''market stability reserve'' and increasing the linear reduction factor to 2.2 %, both only starting in 2021) is not sufficient for the national 40 % target to be met. There-fore, it is of crucial importance for the German government, if it takes its national com-mitments seriously, to call for a more ambitious reform of the EU ETS which results in larger emission reductions before 2020. In principle a solution on EU level is preferable to ensure the coherency and credibility of EU climate policy. Nevertheless, Germany should begin a discussion on national level about complementary measures (e.g. regulatory law) so that the national targets can still be met if it is not possible to realize an ambitious reform of the EU ETS on EU level.

  14. Casino Capitalism and Its Legitimacy Impact on the Politico-administrative State in Macau Der Kasino-Kapitalismus in Macau und seine Bedeutung für die Legitimität des politisch-administrativen Systems

    Directory of Open Access Journals (Sweden)

    Sonny Lo

    2009-04-01

    Full Text Available Casino capitalism has its dialectical tendencies in Macau. On the one hand, it stimulates economic growth, provides employment, and strengthens the post-colonial state in Macau during the period of economic boom. On the other hand, casino capitalism can widen the income gap between the rich and the poor, generate addictive gambling, and de-legitimize the post-colonial state in Macau during the global and regional economic downturn. The weaknesses of the politico-administrative state in Macau, including the absence of institutional checks and balances, the frail civil society and the relatively docile mass media, have magnified the negative impacts of casino capitalism on Macau. In response to the negative ramifications, the Macau government has taken measures to be more interventionist, to enhance social welfare, and to prepare contingency plans that would tackle the sudden bankruptcy of any casinos. The central government in Beijing also displays contradictory considerations when it deals with Macau’s casino development, supporting the casino industry while simultaneously encouraging the Macau government to diversify its economy. Overall, casino capitalism not only has contradictory impacts on the Macau city-state but also reveals the inherent contradictions of Beijing’s policy toward the territory’s over-dependence on the casino economy. Der Kasino-Kapitalismus ruft in Macao widersprüchliche TEndenzen hervor: Einerseits stimuliert er das wirtschaftliche Wachstum und stärkt den post-kolonialen Staat in wirtschaftlichen Boomphasen, andererseits kann er aber auch dazu beitragen, dass sich die Einkommensunterschiede zwischen ärmeren und wohlhabenderen Schichten verstärken und damit in Krisenphasen zur Deligitimierung des postkolonialen Staates beitragen.

  15. Radioimmunoassay of serum myoglobin and its signifance for diagnosis and therapy of musculoskeletal diseases. Der radioimmunologische Myoglobinnachweis im Serum und seine Bedeutung bei der Diagnostik und Therapie von Skelettmuskelerkrankungen

    Energy Technology Data Exchange (ETDEWEB)

    Kiessling, W.R.

    1982-01-01

    A commercial test kit for radioimmunologic proof of myoglobin in serum was tested with regard to its specificty, sensitivity, precision, reproducibility, recovery and use in the diagnosis and therapy of musculoskeletal diseases. In the serum of 164 healthy control persons (age: 2-79 years) the individual myoglobin concentrations ranged from 4 to 60 ng/ml. Among 300 patients with muscular diseases extreme myoglobinaemia in acute rhabdomyolysis, polymyositis and dermatomyositis and different progressive muscular dystrophies could be detected. Slightly increased myoglobin concentrations could be proved in a number of patient with amyotrophic lateral sklerosis, neural muscular atrophy and in all cases of spinal muscular atrophy of the Kugelberg-Welander type. Confirmed DMD patients exhibited in about 80% of the cases hypermyoglobinaemia, and about 11% of 43 possible DMD patients showed an increase in myoglobin. Taking acute rhabdomyolysis and myositis as an example, it was found that myoglobin correlates well with the clinical course of these diseases and permits safe inferences as to the efficiency of the therapy chosen.

  16. Image fusion of MRI and fMRI with intraoperative MRI data: methods and clinical relevance for neurosurgical interventions; Fusion von MRT-, fMRT- und intraoperativen MRT-Daten. Methode und klinische Bedeutung am Beispiel neurochirurgischer Interventionen

    Energy Technology Data Exchange (ETDEWEB)

    Moche, M.; Busse, H.; Dannenberg, C.; Schulz, T.; Schmidt, F.; Kahn, T. [Universitaetsklinikum Leipzig (Germany). Klinik und Poliklinik fuer Diagnostische Radiologie; Schmitgen, A. [GMD Forschungszentrum Informationstechnik GmbH-FIT, Sankt Augustin (Germany); Trantakis, C.; Winkler, D. [Klinik und Poliklinik fuer Neurochirurgie, Universitaetsklinikum Leipzig (Germany)

    2001-11-01

    The aim of this work was to realize and clinically evaluate an image fusion platform for the integration of preoperative MRI and fMRI data into the intraoperative images of an interventional MRI system with a focus on neurosurgical procedures. A vertically open 0.5 T MRI scanner was equipped with a dedicated navigation system enabling the registration of additional imaging modalities (MRI, fMRI, CT) with the intraoperatively acquired data sets. These merged image data served as the basis for interventional planning and multimodal navigation. So far, the system has been used in 70 neurosurgical interventions (13 of which involved image data fusion - requiring 15 minutes extra time). The augmented navigation system is characterized by a higher frame rate and a higher image quality as compared to the system-integrated navigation based on continuously acquired (near) real time images. Patient movement and tissue shifts can be immediately detected by monitoring the morphological differences between both navigation scenes. The multimodal image fusion allowed a refined navigation planning especially for the resection of deeply seated brain lesions or pathologies close to eloquent areas. Augmented intraoperative orientation and instrument guidance improve the safety and accuracy of neurosurgical interventions. (orig.) [German] Ziel dieser Arbeit waren die Realisierung und klinische Bewertung einer Bildfusion praeoperativer MRT- und fMRT-Bilder mit intraoperativen Datensaetzen eines interventionellen MRT-Systems am Beispiel neurochirurgischer Eingriffe. Ein vertikal offenes 0,5-T-MRT-System wurde mit einem erweiterten Navigationssystem ausgestattet, welches eine Integration zusaetzlicher Bildinformationen (Hochfeld-MRT, fMRT, CT) in die intraoperativ akquirierten Datensaetze erlaubt. Diese fusionierten Bilddaten wurden zur Interventionsplanung und multimodalen Navigation verwendet. Bisher wurde das System bei insgesamt 70 neurochirurgischen Eingriffen eingesetzt, davon 13 mit Bilddatenfusion (rund 15-minuetiger Zusatzaufwand). Das erweiterte Navigationssystem zeichnet sich im Vergleich zur systemeigenen Navigation auf der Basis kontinuierlich akquirierbarer Real-time-Bilder durch eine schnellere Bildwiederholung und eine hoehere Bildqualitaet aus. Der Vergleich beider Navigationsbilder erlaubt das fruehzeitige Erkennen von Patienten-bzw. Gewebeverlagerungen. Die multimodale Bildfusion erlaubte eine differenziertere Navigationsplanung, insbesondere bei der Resektion tief liegender Hirntumoren oder bei Laesionen in enger Nachbarschaft zu eloquenten Arealen. Die erweiterte intraoperative Orientierung bzw. Instrumentenfuehrung erhoeht die Sicherheit und Genauigkeit neurochirurgischer Interventionen. (orig.)

  17. Review: Nicola Döring (2003. Sozialpsychologie des Internet. Die Bedeutung des Internet für Kommunikationsprozesse, Identitäten, soziale Beziehungen und Gruppen [Social Psychology of the Internet. The Importance of the Internet for Communication Processe

    Directory of Open Access Journals (Sweden)

    Gerald Kral

    2004-01-01

    Full Text Available This book is the second, completely revised and extended edition of the first publication from 1999 that soon became one of the most important publications about Internet research in the German-speaking world. The new edition takes into account new research findings and updates the book to the present state of research. It begins with the history and the development of the Internet, describes the various applications and services available over the Internet, presents theories of computer-mediated communication, and outlines methods and results of online-research into the impact of the Internet on identity and social relationships to individual users and groups of users. All relevant issues of this field of research are presented. The goal of the book is more a broad overview of current research, rather than extensively detailed information. The book represents a not-to-be-neglected guide for all scientists dealing with psychological aspects of Internet research. URN: urn:nbn:de:0114-fqs0401349

  18. Review: Petra Fosen-Schlichtinger (2002. Über die gesellschaftspolitische Bedeutung von Pränataldiagnostik und künstlicher Befruchtung [The Social and Political Importance of Prenatal Diagnoses and in vitro Fertilization}

    Directory of Open Access Journals (Sweden)

    Torsten Junge

    2005-01-01

    Full Text Available This volume deals with reproductive medicine, offspring and the social perception of disability. The family and its offspring have become, in modern times, a project for individual life-planning. A child promises a certain social status, particularly if s/he conforms to society's ideal of a competitive child. Due to its peculiarity, the "special" (namely disabled, child poses various barriers and challenges for the parents and the environment. The social climate, therefore, does not sufficiently expose the possibility of disability in offspring. Developing medical technologies, through prenatal medicine or artificial insemination, provide ways for individuals to actively participate in the shaping of one's offspring and to turn "off" disability. The book aims (1 to outline the historical, political and cultural contexts of pregnancy, birth and offspring in modern society by means of socio-philosophical, modern theoretical and psychoanalytical arguments, and (2 to make the analysis of the current circumstances productive. The theoretical argument is complemented by the description of medical technical procedures, their risks and potential. The practical side is strengthened by interviews with clinicians from the reproductive medicine sector. The plethora of the study's various elements is not classifiable at first sight and a stronger and more concise list of contents would have been desirable. Despite this small weakness, the volume provides an informative overview about the role and meaning of procedures in reproductive medicine within specific social contexts. URN: urn:nbn:de:0114-fqs050175

  19. The significance of diagnostic MRI for visualisation of trauma-induced cervical nerve root avulsion. Case report; Die Bedeutung der MRT-Diagnostik zur Darstellung traumatisch bedingter zervikaler Wurzelausrisse. Kasuistik

    Energy Technology Data Exchange (ETDEWEB)

    Muth, C P [Carl-Thiem-Klinikum, Cottbus (Germany). Inst. fuer Radiologie; Biemelt, F [Carl-Thiem-Klinikum, Cottbus (Germany). Inst. fuer Radiologie; Kamenz, M [Carl-Thiem-Klinikum, Cottbus (Germany). Inst. fuer Radiologie

    1996-11-01

    The article is intended to show the value of MRI for diagnostic visualisation and evaluation of posttraumatic nerve root avulsion as a brachial plexus injury. (orig./MG) [Deutsch] Das Ziel der Arbeit besteht in der Darstellung des Wertes der MRT-Diagnostik bei der Abklaerung traumatischer Wurzelausrisse im Bereich des Plexus brachialis. (orig./MG)

  20. Internet-Pranger auf Verdacht: Zur Bedeutung der Unschuldsvermutung für die Information der Öffentlichkeit über lebensmittelrechtliche Verstöße nach § 40 Abs. 1a Nr. 2 LFGB / Christoph Dannecker

    Index Scriptorium Estoniae

    Dannecker, Christoph

    2013-01-01

    Avalikkuse teavitamisest toiduainetega seotud seaduserikkumistest toiduaineteseaduse (Lebensmittel-, Bedarfsgegenstände- und Futtermittelgesetzbuch) § 40 lõige 1a tähenduses, mis sätestab, et avalikkust teavitab pädev asutus

  1. Role of storage technologies to integrate high shares of renewable electricity generation into the electricity system of Germany. Simulation and optimization; Rolle und Bedeutung der Stromspeicher bei hohen Anteilen erneuerbarer Energien in Deutschland. Speichersimulation und Betriebsoptimierung

    Energy Technology Data Exchange (ETDEWEB)

    Hartmann, Niklas

    2013-06-13

    The share of renewable electricity generation of gross electricity consumption in Germany increased from 6.8 % to about 20 % during the years of 2000 and 2011. This share will increase even more in the future. The greater part of the renewable electricity generation is characterized by significant fluctuations, which can only be planned to a limited extent. Hence, the electricity system in Germany faces the challenge to integrate an increasing amount of fluctuating renewable electricity generation. Additionally the system stability needs to be ensured, despite a decreasing capacity in conventional power plants. One option to support the integration of large amounts of renewable electricity generation and to enhance system stability is the deployment of storage technologies. The aim of this research was to analyze the role of storage technologies to integrate high shares of renewable electricity generation into the electricity system of Germany. To achieve this aim, adiabatic compressed air energy storage, diabatic compressed air energy storage and mobile battery storage systems were simulated and compared with a pumped hydro storage as the reference storage system. Key characteristics of these storage systems were modeled within a fundamental stochastic unit commitment model of the German power markets (Joint-Market-Model) in order to analyze the effect of the implementation of these storage systems on the overall cost of the electricity system. Additionally, the operation of the storages in an electricity system with high shares of renewable energy was evaluated. The results show that the integration of large shares of renewable electricity generation into the grid can only be achieved with a substantial implementation of storage systems. To integrate 50 % of renewable energy, a storage power of 27 GW and storage capacity of 245 GWh is needed. For a renewable energy share of 80 %, a storage power of 78 GW and a storage capacity of 6.3 TWh are necessary. A 100 % renewable energy share requires a storage power of 139 GW and a storage capacity of 83 TWh. This also requires a significant capital expenditure. One option to reduce the overall system costs without compromising the system stability is to allow ''curtailment'' of wind and solar power. Curtailment is hereby only used, if it leads to lower operating costs of the system. For 50 % share of renewable energy the storage power can be reduced from 27 GW to almost 11 GW at constant storage capacity. The required storage capacity is reduced from 6.3 TWh to 5.4 TWh and the storage power from 78 GW to 66 GW for a share of 80 % of renewable energy. For a share of 100 % of renewable energy, the requirement of storage capacity is reduced from 83 TWh to 57 TWh and of storage power from 139 GW to 106 GW. In all assessments, where curtailment is allowed, the system costs are reduced. With this procedure only a minor share of renewable electricity generation (<1 %) is hereby not integrated into the grid. Furthermore, in this research the effects of different charging strategies of electric vehicles are analyzed. An uncontrolled charging, where the electric vehicles are charged at the instant they are connected to the grid is compared with a controlled charging (Vehicle-to-grid, V2G), where the time of charging can be delayed due to economic reasons until the starting time of the next trip. However, the controlled charging strategy of electric vehicles was found to have very little positive effect on the system costs. In a year with low wind and solar supply (reduced wind and solar supply by 15 %), the system stability is not given for a share of renewable electricity generation of 80 % and 100 %. To ensure the system stability for very high shares of renewable electricity generation, the power plant portfolio needs to be determined based on a load curve with yearly low wind and solar supply.

  2. Wissenschaftliche Netzwerke und klassifikatorische Bedeutung im Psychiatrischen Handbuch (Traité de Psychiatrie der Medizinisch-Chirurgischen Enzyklopädie (1947-1977 am Beispiel des Begriffes der Psychose

    Directory of Open Access Journals (Sweden)

    Emmanuel Delille

    2009-12-01

    Full Text Available Der deutsche Ausdruck ‘Psychose’ (Carl Friedrich Canstatt, 1841 ist der wissenschaftliche Begriff, der sich zur Bezeichnung von bestimmten Geisteskrankheiten durchgesetzt hat. Als Ausgangsperspektive für die Untersuchung dient dabei die Geschichte der wissenschaftlichen Soziabilitäten. Der Zeitraum (1947-1977 wurde entsprechend der Tätigkeit des französischen Psychiaters Henri Ey im Rahmen der Gruppe „l’Evolution Psychiatrique“ (die Psychiatrische Entwicklung abgesteckt. Ich untersuche in ...

  3. Gaby Temme, Christine Künzel (Hg.: Hat Strafrecht ein Geschlecht? Zur Deutung und Bedeutung der Kategorie Geschlecht in strafrechtlichen Diskursen vom 18. Jahrhundert bis heute. Bielefeld: transcript Verlag 2010.

    Directory of Open Access Journals (Sweden)

    Monika Frommel

    2011-03-01

    Full Text Available Das moderne Strafrecht sollte informelle Geschlechternormen neutralisieren. Dies gelingt auch, kann aber bei der Strafzumessung unterlaufen werden. Wie der vorliegende Band in historisch ausgerichteten Einzelstudien zeigt, war das Strafrecht nie so objektivierend, wie es die Reformen seit den 1970er Jahren anstreben. Am Beispiel der Kindsmörderin wird nachgewiesen, dass der Verstoß gegen Geschlechtertugenden auch heute noch jederzeit mit harten Strafen sanktioniert werden kann.Modern criminal law should neutralize informal gender norms. This is by and large successful; however, it can be circumvented in the assessment of penalty. As shown by the historically orientated individual articles of this anthology, criminal law has never been as objectifying as the reforms since the 1970s are aspiring. Using the example of the female infanticide, the anthology proves that the violation of gender virtues can at all times still be sanctioned with severe penalties.

  4. Bioaccumulation of heavy metals in the zebra mussel Dreissena polymorpha in the rivers Danube and Drau and its role as a bioindicator organism; Schwermetallbelastung von Dreissena polymorpha in Donau und Drau und ihre Bedeutung als Bioindikator

    Energy Technology Data Exchange (ETDEWEB)

    Luschuetzky, E.F. [Univ. Wien, Inst. fuer Zoologie, Abt. fuer Ultrastrukturforschung und Elektronenmikroskopie, Wien (Austria)

    2005-07-01

    Goal and scope. This study was undertaken to investigate the differences in heavy metal burden between the organisms and environmental compartments and to evaluate the role of Dreissena polymorpha as a bioindicator organism. Methods. The concentrations of zinc, copper, cadmium and lead in whole soft body and selected tissues of D. polymorpha at two river habitats in Austria were examined using atomic absorption spectroscopy (AAS). Concentrations in organisms were compared to those in sediment and water. Results and conclusion. Zebra mussels of the river Drau showed generally higher heavy metal concentrations as compared to mussels of the river Danube and contained elevated zinc and cadmium levels as compared to metal concentrations found in soft tissues of zebra mussels from uncontaminated sites in Germany and The Netherlands. The essential metals zinc and copper were mainly accumulated in gills, foot and byssal gland tissue of the mussel, in contrast to the non-essential metals cadmium and lead which were found predominantly in the midgut gland. The heavy metal concentrations in both, sediments and mussel tissue, were higher than in water samples. There was no correlation between the concentrations in water and in the organisms except for zinc. In contrast, correlations were found between concentrations in sediments and mussel soft tissue. Recommendation and perspective. Further investigations should include the examination of sediments and consider the mechanism of food uptake to assess the role of D. polymorpha as a bioindicator organism. (orig.)

  5. The influence of Brachyura on oil polluted subtropical intertidal shores - an example from the Arabian Gulf; Die Bedeutung von Krabben (Brachyura) bei der Regeneration von kohlenwasserstoffkontaminierten subtropischen Flachkuesten am Beispiel des Arabisch Persischen Golfs

    Energy Technology Data Exchange (ETDEWEB)

    Barth, H.J. [Geographisches Inst., Univ. Heidelberg (Germany)

    2006-11-15

    Objectives. The second Gulf War (1991) led to the largest oil spill in human history. Over 770 km of coastline from southern Kuwait to Abu Ali Island (Saudi Arabia) were smothered with oil and tar, erasing most of the local plant and animal communities. This long term study was designed to reveal the processes of natural regeneration within the salt marsh ecosystems as well as the processes counter productive to regeneration. Methods. Field data were collected along permanent transect lines during annual visits from 1994 to 2004. Soil analysis included grain size, carbonate, pH and total hydrocarbon (Soxhlet extraction). Heavy metals were determined by Inductively Coupled Plasma Atomic Emission Spectroscopy. Hydrocarbons were analysed by High Performance Liquid Chromatography. Results. The dominant processes of regeneration are characterized by four types of indicators. These are (1) the composition of hydrocarbon compounds remaining in the soil, (2) the hardness of the soil surface, (3) the abundance of laminated cyanobacterial mats, and (4) the abundance and diversity of macrofauna. Cyanobacteria turned out to conserve the oil within the soil where they built laminated mats sealing the surface and thus, preventing oxygen from penetrating the substrate. On the other hand, crustaceans were the first macrofauna returning to contaminated soils. Following bioturbation by the crustaceans significantly accelerates the biodegradation of the hydrocarbons. Since the occurrence of the crabs (mainly Cleistotoma dotilliforme) is primarily restricted to tidal channels the density of the channel network between the affected salt marshes determines the time which is needed for regeneration. (orig.)

  6. The practical importance of the Energy Charta Agreement - a EU charta for the German power industry?; Die praktische Bedeutung des Energiechartavertrages - eine EG-feste ''Grundrechtscharta'' fuer die deutsche Energiewirtschaft?

    Energy Technology Data Exchange (ETDEWEB)

    Happ, R. [Luther Rechtsanwaltsgesellschaft, Hamburg (Germany)

    2007-01-15

    In the last weeks of 2006, the EU repeatedly demanded of Russia to ratify the ECT (Energy Charta Agreemen) in order to ensure reliable supply of Russian natural gas and petroleum to the European countries. But this is not the only function of the Energy Charta Agreement; basically, it is a charta that defines the basic rights of the power industry, so that all state interventions can be weighed against an independent legal basis. As the European Communities are parties to the contract, EU actions and decisions can be checked as well, and compensation claims can be brought to an international court. The contribution shows how the Energy Charta Agreement can help to provide better legal and investment safety. (orig.)

  7. Certifying green electricity in the EC single market. Presentation of different models and their importance for the freedom of movement of goods; Gruenstromzertifikate im EG-Binnenmarkt. Eine Darstellung verschiedener Modelle und ihrer Bedeutung fuer die Warenverkehrsfreiheit

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, Thorsten; Bitsch, Christian [Wuerzburg Univ. (Germany). Forschungsstelle Umweltenergierecht

    2008-11-15

    With the guideline 2001/77/EG, certificates of origin were introduced in the European Community in order to prove the production of a certain quantity of electricity from renewable energies. These certificates of origin are designated as green electricity certificates and are established as economic goods. In the political debate according to the development of the European legislation, these plans are criticised. Different alternative models were developed. Actually the introduction of two different certificate types is discussed. Under this aspect, the authors of the contribution under consideration report on the different models. The task of the green electricity certificates in the European single market and the consequences for the present discussion are described.

  8. The importance of further education. In times of demographical change using the example of energy industry; Die Bedeutung der Weiterbildung in Zeiten des demografischen Wandels am Beispiel der Energiewirtschaft

    Energy Technology Data Exchange (ETDEWEB)

    Schmitz, Marcus [IGS Organisationsberatung GmbH, Koeln (Germany)

    2010-07-01

    The demographical development in Germany has an impact on the economy. Especially the qualified manpower supply will change not only in our country, but also in all other Western industrial nations. Companies would be well advised, if they previously anticipated the consequences they will face, to check and adjust their human resource strategies, if necessary. The target is to have specialists and executive staff available, according to quantitative as well as qualitative needs. Further education plays a decisive role to meet a shortage of human resources. (orig.)

  9. Dental CT in the planning of surgery. Role in the oromaxillofacial area from the dentist's point of view; Dental-CT zur Planung chirurgischer Eingriffe. Bedeutung im oro-maxillofazialen Bereich aus zahnaerztlicher Sicht

    Energy Technology Data Exchange (ETDEWEB)

    Solar, P. [Universitaetsklinik fuer Zahn-, Mund- und Kieferheilkunde Wien (Austria). Abt. fuer Orale Chirurgie; Gahleitner, A. [Universitaetsklinik fuer Radiodiagnostik Wien (Austria). Abt. fuer Osteologie

    1999-12-01

    Dental computer assisted tomography (Dental CT) represents a valuable addition to the diagnostic spectrum for planning oral and maxillofacial surgery. High resolution CT and specially designed computer software allow representation of the jaws in different planes that are easy to match. They further allow the display of very small structures relevant to oral surgical interventions and reveal their spatial relationship in three dimensions. Thus, communication between dentists and radiologists may be intensified and supported by usage of modern telecommunication systems. Dental CT is indicated, when clinical and conventional radiological techniques will not allow exact interpretation of the situation. It is modern oral implantology that primarily benefits from computer software enabling the assessment of surgical sites in the presurgical phase. Such planning was not yet possible using two dimensional radiographic techniques. The dental-implantological part expects from radiography sharply defined contours of the external bony contours and the mandibular canal, exactly defined relation between slices and planes, no distortion in the orthoradial planes, tools for reliable measurements of distances, angles and volumes, possibility to transmit pictures electronically or on hardcopy without loss of quality. (orig.) [German] Dentale Computertomographie (Dental-CT) stellt neben Orthopantomographie, intraoralem Zahnfilm und Fernroentgen eine wertvolle Erweiterung des diagnostischen Spektrums zur Planung chirurgischer Eingriffe im oro-maxillofazialen Bereich dar. Durch die Moeglichkeiten von hochaufloesendem CT und der Entwicklung von Software zur Darstellung des Kiefers in raeumlich leicht zuordenbaren Schichtebenen, lassen sich auch kleinste, zahnaerztlich-chirurgisch relevante Strukturen und ihre Lagebeziehung zueinander in allen drei Ebenen darstellen. Dadurch kann es zur intensiveren Kommunikation zwischen Zahnarzt und Radiologen kommen, was durch die Inanspruchnahme moderner Telekommunikationssysteme auch erleichtert wird. Dental-CT hat primaer dort ihre Aufgabe, wo klinische und konventionell radiologische Verfahren keine exakte Beurteilbarkeit der Situation ermoeglichen. Vor allem in der modernen Implantologie ergeben sich durch den Einsatz spezieller Computerprogramme Moeglichkeiten der Operationsplanung, welche mit zweidimensionalen Roentgenverfahren nicht moeglich sind. Die Anforderungen von zahnaerzlich-implantologischer Seite an das Roentgen sind: Klare Darstellung der aeusseren Knochenkonturen und des Mandibularkanals, eindeutige raeumliche Zuordnung der einzelnen Schnittbilder zueinander, Verzerrungsfreiheit in den orthoradialen Ebenen (Schnittebenen tatsaechlich im rechten Winkel auf die aeusseren Tangenten), Vermessbarkeit und Ausgabenmoeglichkeit auf einem Bildtraeger ohne Qualitaetsverlust. (orig.)

  10. Thermal construction unit activation with supply air gains significance. Ceilings cooling - supply air heating - more than 50 % energy conservation; Thermische Bauteilaktivierung mit Zuluft gewinnt an Bedeutung. Decke kuehlen - Zuluft erwaermen - mehr als 50% Energie einsparen

    Energy Technology Data Exchange (ETDEWEB)

    Schmid, Wolfgang

    2009-05-15

    In the year 2001, in Stuttgart (Federal Republic of Germany) the first office building was established which uses a thermal construction unit activation with air as cooling agent. Today, the system ''Concret-cool'' already is installed in more than 40 buildings. Computations show that due to the room heating by means of internally finned ventilation pipes embedded in concrete more than 50 % less energy in comparison to comparable systems can be used. In his Green Building project ''Skyline Tower'' in Munich (Federal Republic of Germany), also star architect Helmut Jahn uses the know-how of the manufacturer of ventilation systems from Stuttgart. As one of the first multi-storied buildings in Munich, ''Skyline Tower'' with its 23 floors was prized with the pre-certificate of the German quality seal ''sustainable building ''in gold.

  11. The internet has to become more important for the trademark communication of energy supply companies; Die Bedeutung des Internet fuer die Markenkommunikation der EVU. Potenzial wird nur unzureichend genutzt

    Energy Technology Data Exchange (ETDEWEB)

    Grassmann, B. [Marketing und Vertrieb, T-Online International AG, Darmstadt (Germany)

    2003-03-24

    As a precondition for future multi utility offers, energy supply companies are nowadays focusing on customer orientation and the extension of trademarks. Within the next three years, the acquisition of new clients (who intend to change the energy supplier) will be the central issue. Thus, there are great challenges ahead. The internet offers an unrecognized potential for communication so far, but only 0.3 per cent of the overall advertising expenses are invested in online communication. (orig.) [German] Die Energieversorgungsunternehmen konzentrieren sich heute auf Kundenorientierung und Markenausbau als Voraussetzung fuer kuenftige Multi-Utility-Angebote. In drei Jahren wird die Akquisition neuer Wechselkunden das zentrale Thema sein. Die Herausforderungen sind also gross. Das Internet bietet bislang verkannte Kommunikationspotenziale, aber nur 0,3% der Gesamtwerbeausgaben werden in Online-Kommunikation investiert. (orig.)

  12. Ultrasound-guided image fusion with computed tomography and magnetic resonance imaging. Clinical utility for imaging and interventional diagnostics of hepatic lesions; Ultraschallgestuetzte Bildfusion mittels CT und MRT. Klinische Bedeutung fuer die bildgebende und interventionelle Diagnostik von Leberlaesionen

    Energy Technology Data Exchange (ETDEWEB)

    Clevert, D.A.; Helck, A.; Paprottka, P.M.; Trumm, C.; Reiser, M.F. [Klinikum der Ludwig-Maximilians-Universitaet, Campus Grosshadern, Institut fuer Klinische Radiologie, Muenchen (Germany); Zengel, P. [Klinikum der Ludwig-Maximilians-Universitaet, Campus Grosshadern, Klinik fuer Hals-, Nasen- und Ohrenheilkunde, Muenchen (Germany)

    2012-01-15

    Abdominal ultrasound is often the first-line imaging modality for assessing focal liver lesions. Due to various new ultrasound techniques, such as image fusion, global positioning system (GPS) tracking and needle tracking guided biopsy, abdominal ultrasound now has great potential regarding detection, characterization and treatment of focal liver lesions. Furthermore, these new techniques will help to improve the clinical management of patients before and during interventional procedures. This article presents the principle and clinical impact of recently developed techniques in the field of ultrasound, e.g. image fusion, GPS tracking and needle tracking guided biopsy and discusses the results based on a feasibility study on 20 patients with focal hepatic lesions. (orig.) [German] Bei der Bildfusion von Ultraschall mit anderen schnittbildgebenden Verfahren (CT, MRT) handelt es sich um ein relativ neuartiges Verfahren, welches unter Studienbedingungen jedoch bereits erfolgreich eingesetzt wurde. In der folgenden Machbarkeitsstudie soll der Nutzen weiterfuehrender Anwendungen der sonographischen Bildfusion, dem so genannten Global-Positioning-System- (GPS-) und Needle-Tracking, untersucht werden. Dabei handelt es sich um Instrumente, die insbesondere die Diagnostik und das Staging (GPS-Tracking) bzw. die bioptische Abklaerung (Needle-Tracking) von Patienten mit fokalen Leberlaesionen erleichtern. In diesem Artikel werden das Prinzip und die Anwendungsmoeglichkeiten dieser neuen Techniken anhand konkreter Beispiele in einem Kollektiv von 20 Patienten mit fokalen Leberlaesionen vorgestellt und erlaeutert. (orig.)

  13. Nutrition impact symptoms in advanced cancer patients: frequency and specific interventions, a case?control study

    OpenAIRE

    Omlin, Aurelius; Blum, David; Wierecky, Jan; Haile, Sarah R.; Ottery, Faith D.; Strasser, Florian

    2013-01-01

    Background Involuntary weight loss (IWL) is frequent in advanced cancer patients causing compromised anticancer treatment outcomes and function. Cancer cachexia is influenced by nutrition impact symptoms (NIS). The aim of this study was to explore the frequency of NIS in advanced patients and to assess specific interventions guided by a 12-item NIS checklist. Methods Consecutive patients from an outpatient nutrition-fatigue clinic completed the NIS checklist. The NIS checklist was developed b...

  14. Composantes psychologiques des plaintes relatives à la taille du pénis après implantation d'une prothèse pénienne

    OpenAIRE

    Kempeneers, Philippe; Andrianne, Robert; Mormont, Christian; Jeanmart, F.

    2004-01-01

    A survey questionnaire completed by 39 users of penile prosthesis shows that complaints related to the size of the implanted penis involve a decrease in satisfaction towards the prosthetic device. However, a reduced penile size is not necessary considered as a problem by all patients. Beyond functional considerations, the disappointment concerning the length of the penis is mostly related to the representation of a virility debased by the notions of artifice and assistance which are ass...

  15. AVALIAÇÃO DOS GÂNGLIOS REGIONAIS NO CARCINOMA EPIDERMÓIDE DO PÊNIS (CEP ATRAVÉS DE UM ÍNDICE DE RISCO

    Directory of Open Access Journals (Sweden)

    Cologna A. J.

    2001-01-01

    Full Text Available O objetivo desse estudo foi investigar a validade de um índice de risco (IR no prognóstico de metástases ganglionares no carcinoma epidermóide do pênis (CEP. Foram analisados 53 pacientes com CEP atendidos no Hospital das Clínicas da FMRP-USP, de janeiro de 1978 a dezembro de 1995. A idade variou de 32 a 97 anos. Os tumores foram graduados de acordo com a classificação de Broders e estadiados retrospectivamente (TNM 1999. O IR foi determinado pela soma de TeG (IR = T+G. A linfadenectomia inguinal bilateral (LD foi indicada naqueles que apresentaram gânglios suspeitos após a antibioticoterapia ou que vieram apresentar alterações durante o período de observação. Faleceram 17 pacientes; A LD foi realizada em 14 pacientes e os 39 restantes permaneceram em observação clínica, sendo que em 8 deles foi feito LD após tempo mediano de 9 meses. Dos pacientes com índice de risco 2 e 3 92% e 80% respectivamente não apresentavam metastase ganglionar, ao passo que a totalidade daqueles com IR=6 tinha gânglios comprometidos. A associação dos grupos 2 e 3, comparada ao conjunto 4, 5 e 6, mostrou percentual maior de comprometimento nestes últimos (p = 0,0046. Dos 36 pacientes inicialmente No, 27 apresentavam IR 2 ou 3, dos quais 5 evoluíram para N+ (19%; os 9 restantes eram IR > 4 e 3 também evoluíram para N+ (33%. Apesar da diferença, não houve significância estatística entre eles (p = 0,3837. Embora tenha ocorrido maior comprometimento naqueles com IR > 4, o índice de risco não foi capaz de identificar previamente pacientes que evoluíram para N+.

  16. Infrastructure design & road safety : OECD Workshop B3 (Infrastructure design and road safety) for CEE's and NIS held on 15th-18th November 1994, Prague (Czech Republic). Part 2: Lectures.

    NARCIS (Netherlands)

    2012-01-01

    The workshop 'Infrastructure design and road safety ' was one of the initiatives which the OECO Steering Committee for Road Transport Research developed with the aim of exchanging information in the road transport sector, in order to respond to the urgent needs expressed by Central and Eastern

  17. Genetically Targeted Radiotherapy Utilizing the Human Sodium Iodide Symporter in Human Breast Carcinoma Cells

    National Research Council Canada - National Science Library

    Krager, Kimberly; Domann, Frederick E

    2006-01-01

    .... Clones were grown and are currently being screen for radioactive accumulation. The stable NIS-expressing cells will then be utilized in determining the level of NIS expression necessary to elicit a bystander effect...

  18. Role of commercial harbours and recreational marinas in the spread of non-indigenous fouling species.

    Science.gov (United States)

    Ferrario, Jasmine; Caronni, Sarah; Occhipinti-Ambrogi, Anna; Marchini, Agnese

    2017-09-01

    The role of commercial harbours as sink and source habitats for non-indigenous species (NIS) and the role of recreational boating for their secondary spread were investigated by analysing the fouling community of five Italian harbours and five marinas in the western Mediterranean Sea. It was first hypothesised that NIS assemblages in the recreational marinas were subsets of those occurring in commercial harbours. However, the data did not consistently support this hypothesis: the NIS pools of some marinas significantly diverged from harbours even belonging to the same coastal stretches, including NIS occurring only in marinas. This study confirms harbours as hotspots for marine NIS, but also reveals that numbers of NIS in some marinas is higher than expected, suggesting that recreational vessels effectively facilitate NIS spread. It is recommended that this vector of NIS introduction is taken into account in the future planning of sustainable development of maritime tourism in Europe.

  19. Andragogy as a didactic perspective in the attitudes of nurse instructors in Finland.

    Science.gov (United States)

    Janhonen, S

    1991-08-01

    In this article the didactic perspectives of nurse instructors (NIs) is examined with the help of andragogy defined by the concepts of self-directed learning, learning as a process and lifelong learning. The results of a pilot study of ongoing research on the educational perspective of NIs, are used as examples to discuss how far NIs have accepted the features of andragogy as their didactic perspective both in their public stance and in their actions as described by NIs themselves.

  20. Nutrition impact symptoms in advanced cancer patients: frequency and specific interventions, a case-control study.

    Science.gov (United States)

    Omlin, Aurelius; Blum, David; Wierecky, Jan; Haile, Sarah R; Ottery, Faith D; Strasser, Florian

    2013-03-01

    Involuntary weight loss (IWL) is frequent in advanced cancer patients causing compromised anticancer treatment outcomes and function. Cancer cachexia is influenced by nutrition impact symptoms (NIS). The aim of this study was to explore the frequency of NIS in advanced patients and to assess specific interventions guided by a 12-item NIS checklist. Consecutive patients from an outpatient nutrition-fatigue clinic completed the NIS checklist. The NIS checklist was developed based on literature review and multiprofessional clinical expert consensus. Chart review was performed to detect defined NIS typical interventions. Oncology outpatients not seen in the nutrition-fatigue clinic were matched for age, sex, and tumor to serve as controls. In 52 nutrition-fatigue clinic patients, a mixed cancer population [IWL in 2 months 5.96 % (mean)], the five most frequent NIS were taste and smell alterations 27 %, constipation 19 %, abdominal pain 14 %, dysphagia 12 %, and epigastric pain 10 %. A statistically significant difference for NIS typical interventions in patients with taste and smell alterations (p = 0.04), constipation (p = 0.01), pain (p = 0.0001), and fatigue (p = 0.0004) were found compared to the control population [mixed cancer, 3.53 % IWL in 2 months (mean)]. NIS are common in advanced cancer patients. The NIS checklist can guide therapeutic nutrition-targeted interventions. The awareness for NIS will likely evoke more research in assessment, impact, and treatment.

  1. Experiment study with baculovirus-mediated transfer of the thyroid sodium/iodide symporter gene into thyroid cancer for a targeted radiotherapy

    International Nuclear Information System (INIS)

    Zhang Yifan; Li Biao; Zhao Long; You Bei; Yin Guizhi; Zhu Chengmo

    2004-01-01

    Objective: To explore the feasibility of thyroid cancers for radiotherapy by using baculoviral vector to deliver the NIS gene into the tumor cells. Method: Constructed a recombinant baculovirus encoding the human NIS gene under the control of the cytomegalovirus promoter. Using a mouse monoclonal antibody and a FITC-labeled antimouse antibody to confirm expression of the NIS protein of infected tumor cells by immunofluorescence. In vitro iodide uptake experiments were carded out on BacNIS-infected tumor cells to further characterize the BacNIS virus, and cell killing with 131I and clonogenic assay were performed on BacNIS-infected cell to observe the selective killing effect of 1311 on NIS-expressing cells. Results: Infection of thyroidcancer cells (FTC-133, W3) with BacNIS resulted in perchlorate-sensitive 125I uptake by these cells to a higher level than that in noninfected cells. But 1251 uptake of 8505C is very low. Demonstrating that the BacNIS vector can function in tumor cells. In addition, AdNIS-infected tumor cells were selectively killed by exposure to 1311, as revealed by clonogenicassays, higher than that in nontreated tumors. Conclusions: AdNIS is very efficient in triggering iodide uptake by infected tumor cell, outlining the potential of this novel cancer gene therapy approach for a targeted radiotherapy. (authors)

  2. Optimising measles virus-guided radiovirotherapy with external beam radiotherapy and specific checkpoint kinase 1 inhibition

    International Nuclear Information System (INIS)

    Touchefeu, Yann; Khan, Aadil A.; Borst, Gerben; Zaidi, Shane H.; McLaughlin, Martin; Roulstone, Victoria; Mansfield, David; Kyula, Joan; Pencavel, Tim; Karapanagiotou, Eleni M.; Clayton, Jamie; Federspiel, Mark J.; Russell, Steve J.; Garrett, Michelle; Collins, Ian; Harrington, Kevin J.

    2013-01-01

    Background and purpose: We previously reported a therapeutic strategy comprising replication-defective NIS-expressing adenovirus combined with radioiodide, external beam radiotherapy (EBRT) and DNA repair inhibition. We have now evaluated NIS-expressing oncolytic measles virus (MV-NIS) combined with NIS-guided radioiodide, EBRT and specific checkpoint kinase 1 (Chk1) inhibition in head and neck and colorectal models. Materials and methods: Anti-proliferative/cytotoxic effects of individual agents and their combinations were measured by MTS, clonogenic and Western analysis. Viral gene expression was measured by radioisotope uptake and replication by one-step growth curves. Potential synergistic interactions were tested in vitro by Bliss independence analysis and in in vivo therapeutic studies. Results: EBRT and MV-NIS were synergistic in vitro. Furthermore, EBRT increased NIS expression in infected cells. SAR-020106 was synergistic with EBRT, but also with MV-NIS in HN5 cells. MV-NIS mediated 131 I-induced cytotoxicity in HN5 and HCT116 cells and, in the latter, this was enhanced by SAR-020106. In vivo studies confirmed that MV-NIS, EBRT and Chk1 inhibition were effective in HCT116 xenografts. The quadruplet regimen of MV-NIS, virally-directed 131 I, EBRT and SAR-020106 had significant anti-tumour activity in HCT116 xenografts. Conclusion: This study strongly supports translational and clinical research on MV-NIS combined with radiation therapy and radiosensitising agents

  3. Functional activity of human sodium/iodide symporter in tumor cell lines

    International Nuclear Information System (INIS)

    Petrich, T.; Knapp, W.H.; Poetter, E.

    2003-01-01

    Aim: The sodium/iodide symporter (NIS) actively transports iodide into thyrocytes. Thus, NIS represents a key protein for diagnosis and radioiodine therapy of differentiated thyroid cancer. Additionally, in the future the NIS gene may be used for cancer gene therapy of non-thyroid-derived malignancies. In this study we evaluated the functionality of NIS with respect to iodide uptake in a panel of tumor cell lines and compared this to gene transfer efficiency. Methods: A human NIS-containing expression vector and reporter-gene vectors encoding and beta;-Galactosidase- or EGFP were used for transient transfection of 13 tumor cell lines. Following transfection measurements of NIS-mediated radioiodide uptake using Na 125 I and of transfection efficiency were performed. The latter included β;-Galactosidase activity measurements using a commercial kit and observation by fluorescence microscopy for EGFP expression. Results: In contrast to respective parental cells, most NIS-transfected cell lines displayed high, perchlorate-sensitive radioiodide uptake. Differences in radioiodide uptake between cell lines apparently corresponded to transfection efficiencies, as judged from reporter-gene assays. Conclusion: With respect to iodide uptake we provide evidence that NIS is functional in different cellular context. As iodide uptake capacity appears to be well correlated to gene transfer efficiency, cell type-specific actions on NIS (e. g. post-translational modification such as glycosylation) are not inhibitory to NIS function. Our data support the promising role of NIS in cancer gene therapy strategies. (orig.)

  4. National Innovation System And Culture A Cross-Country Analysis

    Directory of Open Access Journals (Sweden)

    Joseph Gogodze

    2015-08-01

    Full Text Available This study assesses the relationship between Hofstedes cultural dimensions and the constituents of a National Innovation System NIS. We consider an NIS as a special kind of intangible latent asset and identify its two constituents input and output capital. These are extracted through a modern NIS measurement model based on the Global Innovation Index. Using structural equation models we show that power distance and uncertainty avoidance and long-term orientation and indulgence vs. restraint act through the latent constructs PDUA and LTIV respectively. Moreover individualism IDV and NIS constituents are directly and negatively affected by PDUA. IDV and LTIV directly and positively affect the NIS constituents. Further the results show that masculinity vs. femininity significantly and negatively affects the NIS input constituent and significantly affects the NIS output constituent but its impact is negative for high-income countries and positive for non-high income countries.

  5. Nuclear-plus-interference-scattering effect on the energy deposition of multi-MeV protons in a dense Be plasma.

    Science.gov (United States)

    Wang, Zhigang; Fu, Zhenguo; He, Bin; Hu, Zehua; Zhang, Ping

    2016-09-01

    The nuclear plus interference scattering (NIS) effect on the stopping power of hot dense beryllium (Be) plasma for multi-MeV protons is theoretically investigated by using the generalized Brown-Preston-Singleton (BPS) model, in which a NIS term is taken into account. The analytical formula of the NIS term is detailedly derived. By using this formula, the density and temperature dependence of the NIS effect is numerically studied, and the results show that the NIS effect becomes more and more important with increasing the plasma temperature or density. Different from the cases of protons traveling through the deuterium-tritium plasmas, for a Be plasma, a prominent oscillation valley structure is observed in the NIS term when the proton's energy is close to E_{p}=7MeV. Furthermore, the penetration distance is remarkably reduced when the NIS term is considered.

  6. The role of geodata and geotools in sustainable energy planning. The Interreg project 'North Sea Sustainable Energy Planning'; Die Bedeutung von Geodaten und Geowerkzeugen fuer eine nachhaltige Energieplanung. Das Interreg-Projekt 'North Sea Sustainable Energy Planning'

    Energy Technology Data Exchange (ETDEWEB)

    Knies, Juergen [Jade Hochschule Wilhelmshaven/Oldenburg/Elsfleth, Oldenburg (DE). Inst. fuer Angewandte Photogrammetrie und Geoinformatik (IAPG)

    2012-07-01

    The Interreg IVB project 'North Sea Sustainable Energy Planning' is to promote the development of models for regional development in consideration of renewable energy sources and the implementation of measures for higher energy efficiency in consideration of regional and international boundary conditions. Geodata and geotools provide a basis for sustainable energy planning. The Institute of Applied Photogrammetry and Geoinformatics of Jade Hochschule University developed concepts and geotools to support decision-makers in this task. The concepts and tools are presented in this paper.

  7. Significance of the agreement and results of the Bonn and Marrakesh Conventions with respect to long-term reduction of greenhouse gases. An analysis of supply-side and demand-side aspects; Bedeutung des Bonner Beschlusses und der Ergebnisse aus Marrakesch fuer die langfristige Senkung der Treibhausgasemissionen. Eine Analyse der Angebots- und Nachfrageseite

    Energy Technology Data Exchange (ETDEWEB)

    Wartmann, S.C.; Cremer, C.; Betz, R. [Fraunhofer Institut Systemtechnik und Innovationsforschung, Karlsruhe (Germany)

    2001-07-01

    The article examines in great detail the Bonn resolution and the results of the Marrakesh Convention of the Parties to the UNFCCC with respect to the achievable contributions to a global reduction of greenhouse emissions. The analysis looks at the most important action plans and the relevant mechanisms agreed upon and derives global demand-side and national supply-side estimates and develops relevant projections of lasting greenhouse gas reductions, also indicating further required measures. (orig./CB) [German] Es wird untersucht, inwiefern die Regelungen des Bonner Beschlusses und der Konferenz in Marrakesch tatsaechlich auf das urspruengliche Ziel der Klimarahmenkonvention, langfristige Treibhausgasminderungen, abzielen. Zunaechst werden die wichtigsten Ergebnisse dieser Konferenzen erlaeutert. Anschliessend kann die internationale Nachfrage bzw. das entsprechende Angebot an Emissionsminderungen in Bezug auf Treibhausgasminderungen abgeschaetzt werden. Es ergibt sich ein Ueberblick, ob und in welchem Masse eigene Anstrengungen der verpflichteten Staaten noch notwendig sind. (orig./CB)

  8. Importance and use of an environment management system implementation and innovative optimization approach es using the example of the RAG Deutsche Steinkohle AG; Bedeutung und Nutzung der Implementierung eines Umweltmanagementsystems und innovative Ansaetze zur Optimierung am Beispiel der RAG Deutsche Steinkohle AG

    Energy Technology Data Exchange (ETDEWEB)

    Polysos, Julia

    2014-07-01

    Environmental protection is an important business objective in RAG Deutsche Steinkohle AG (DSK). The management of the company intends the company wide certification according DIN ISO 14001. The law concerning the hard coal financing includes a continuous and socially compatible staff reduction. The company is aimed to manage the hard coal phase-out process considering a sustainable handling of the long-term contamination including public acceptance. The optimization potential includes the implementation and continuation of an area-wide environment management system, the realization of the commissioning management and the environmental evaluation.

  9. Der Aufbau mentaler Modelle durch bildliche Darstellungen: Eine experimentalle Studie uber die Bedeutung der Merkmalsdimensionen Elaboriertheit und Strukturierheit im Sachunterricht der Grundschule (The Development of Mental Processes through Graphic Representation with Diverging Degrees of Elaboration and Structurization: An Experimental Study Carried Out in Elementary Science Instruction in Primary School).

    Science.gov (United States)

    Martschinke, Sabine

    1996-01-01

    Examines types of graphical representation as to their suitability for knowledge acquisition in primary grades. Uses the concept of mental models to clarify the relationship between external presentation and internal representation of knowledge. Finds that students who learned with highly elaborated and highly structured pictures displayed the…

  10. (Environmental) Panel measures in European law. Importance of the judgement Rs C-176/03 of the European Court, comission/council; (Umwelt-)Strafrechtliche Massnahmen im Europarecht. Bedeutung des EuGH-Urteils Rs C-176/03, Kommission/Rat

    Energy Technology Data Exchange (ETDEWEB)

    Foerster, M.

    2007-07-01

    The problem of international criminality strengthened by the progressive European integration. In particular, this is applied to the environmental criminality, since damages of the environment are not bound to the borders of individual states. Due to the appearing liberty rights, defaults on European level were introduced, whose conversion and penetration ensure effective further effective protection of the right property for the environment. The European Commission raised a complaint against the conversion of the skeleton resolution because of the interference of the union-legal measure into community-legal authority. The Court of Justice of the European Community explained this skeleton resolution as authority adverse. The European Court of Justice assumes community-legal authority authorizes in principle to supranational criminal measures. The practical conditions for it are put out in the contribution under consideration. Finally, the new guideline suggestion KOM(2007) 521 is based on these conditions.

  11. Environmental knowledge. Empirical contributions according to the significance of scientific knowledge in the scope of envionmental education exemplified at BIODIESEL as a fuel; Umweltwissen und oekologisches Handeln. Empirische Beitraege zur Bedeutung naturwissenschaftlicher Bildung im Rahmen der Umwelterziehung am Beispiel der Verwendung von BIODIESEL als Treibstoff fuer moderne Dieselkraftfahrzeuge

    Energy Technology Data Exchange (ETDEWEB)

    Hantke, Guenter

    2006-09-15

    The world-wide heating up of the atmosphere as well as the increasing violence and frequency of extreme weather events mainly are due to the emission of carbon dioxide. The emission of carbon dioxide is based on the power production by combustion of fossil sources of energy. The motor traffic causes a substantial portion of these emissions. Under this aspect, the author of the contribution under consideration examines, to what extent young people are sensitized to the relation between power generation by burning fossil sources of energy and the global climatic change and to ecological acting. In the context of the environment project 'Biodiesel as a pollution-free alternative to mineral diesel oil', 55 young people were informed about these relations and interviewed afterwards. After this project, a fifth of the young people transferred to economical diesel engined vehicles. A third of the young person wants to drive with biodiesel based on economic considerations. Young peoples only have a small amount of knowledge on these relations. Only those young people, who drive with biodiesel, are informed better significantly.

  12. Being in the Internet - more than just being ''cool''? e-business and its strategic importance in the utility and energy services industry; Praesenz im Internet - mehr als eine Imagefrage? Die strategische Bedeutung des e-business fuer die Versorgungs- und Energiewirtschaft

    Energy Technology Data Exchange (ETDEWEB)

    Greisinger, T.W. [IBM Global Utility and Energy Services Industry, Oak Brook, IL (United States); Moehl, W. [IBM Deutschland, Mainz (Germany). Vertriebsbereich Versorgungsunternehmen

    2000-04-03

    The Internet and related technologies belong into the daily life of supply and energy industry especially in the business to business sector. But the installation of a colourful homepage is not enough if one wants to remain competitive in the deregulated markets. The strategic implementation of e-business not only in relation to customers but also to optimisation of internal processes is a major success factor. The present article sheds light into these aspects and shows which enterprises especially in the USA have made e-business become a reality. (orig.) [German] Das Internet und verwandte Technologien gehoeren auch in der Versorgungs- und Energiewirtschaft laengst zum Alltag, vor allem im Geschaeftskundenbereich. Mit der Einrichtung einer bunten Homepage ist aber es laengst nicht mehr getan, will man in den deregulierten Maerkten wettbewerbsfaehig bleiben. Der strategische Einsatz von e-business zur Verbesserung von Kundenbeziehungen, aber auch zur Optimierung interner Prozesse ist vielmehr ein entscheidender Erfolgsfaktor geworden. Die Verfasser erlaeutern diese Gesichtspunkte und zeigen auf, welche Unternehmen vor allem in den USA bereits e-business zur Realitaet gemacht haben. (orig.)

  13. Reintroducing regulation? Consequences of the European directives for electricity trade (1228/2003) and gas trade (1775/2005) for the European internal power market; Verordnete Regulierung? Die Bedeutung der Stromhandelsverordnung / Verordnung (EG) Nr. 1228/2003 - und der Gashandelsverordnung - Verordnung (EG) Nr. 1775/2005 - fuer den europaeischen Energiebinnenmarkt

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, J.

    2007-07-01

    On 23 June 2003, the European Parliament and Council issued the directive on grid access for transfrontier electricity trading (EltHVO). It is part of a bundle of directives comprising also directives on electricity and natural gas trading (EltRL and GasRL). This marks the third and final state of unbundling of the European internal power market. In December 2003, the European Commission also announced the issuing of a directive on access to natural gas pipelines (GasHVO) which was issued on 28 September 2005 and came into force on 1 July 2006. While the European Parliament views the legislation as a key project for standardizing the European internal market, others see a danger of centralisation and standardisation of concrete regulation decisions. The publication investigates the consequences of the EltHVO and GAsHVO for the internal power market, especially with a view to the possible danger of centralisation. (orig.)

  14. Prognostic significance of gastrointestinal symptoms and diagnosis in relation to the acute radiation syndrome. A retrospective analysis based on the data base SEARCH; Prognostische Bedeutung von gastrointestinalen Symptomen und Befunden in Zusammenhang mit dem aktuen Strahlensyndrom. Eine retrospektive Datenanalyse anhand der Datenbank SEARCH

    Energy Technology Data Exchange (ETDEWEB)

    Hoebbel, Mathias Niklaus Johannes

    2016-11-17

    The following thesis explores the prognostic significance of gastrointestinal symptoms and diagnoses in relation to acute radiation syndrome. This is a retrospective analysis based on the SEARCH (System of Evaluation and Archiving of Radiation Accidents based on Case Histories) database, which was created by a team of researchers in Ulm in 1998. The SEARCH database compiled health status data of individuals involved in a total of 78 ionized radiation accidents between 1945 and 2003. In the past changes in bloodbuilding systems were considered the defining factor in determining a prognosis regarding survival times. Treatment decisions were made in line with these findings, including stem-cell transplants. In recent history, especially after the nuclear disaster in Chernobyl in 1986, the focus shifted onto other organ systems. As a result it has been proven that significant cutaneous damages present an important influence on survival regardless of haematopoiesis. Several researchers have looked at changes in the gastrointestinal tract and possible correlations with radiation induced multiple organ failure. In this paper, all of the data recorded in SEARCH in regards to gastrointestinal symptoms have been analyzed. These include symptoms such as nausea, vomiting and changes in bowel movement as well as their onset and severity. Radiation-induced oral mucositis was also further investigated. Despite the occasional gaps in data in SEARCH, results from the analysis proved that the occurrence of certain symptoms, their severity and their onset were directly correlated to life expectancy, regardless of the dose estimation, and the pending blood test results. An immediate triage of these patients by skilled medical professionals is imperative to accurate categorization.

  15. Transfer of the sodium/iodide symporter gene into gliomas for radioiodine therapy in vitro

    International Nuclear Information System (INIS)

    Tan Jian; Li Wei; Liu Xiaohua; Xiao Qian; Jia Qiang; Li Ning

    2008-01-01

    Objective: The most frequent brain tumors are the gliomas. Glioblastomas are largely incurable secondary, to their rapid, aggressive and diffusely infiltrative growth pattern and hypervascularity. This study aimed at investigating the possibility of transecting human sodium/iodide symporter (hNIS) gene into human glioma cell lines to facilitate radioactive iodide treatment in vitro. Methods: Transecting hNIS gene into human glioma cell lines U251 was performed by recombinant expression plasmids with lipofectamine 2000-plasmid complexes. The hNIS gene cell lines with stable expression (hNIS-U251) were selected through G418 antibiotic constraint. The hNIS-U251 gene cell lines were then evaluated for their biologic functions, including 125 I uptake assay, 125 I influx-course, 125 I-efflux-course, 131 I inhibitory effect on cellular proliferation by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyhe-trazolium bromide (MTT) assay and flow cytometer. Results: We were successful in transecting hNIS gene into human glioma cell lines by recombinant expression plasmids, and were able to obtain hNIS gene cell lines (hNIS-U251) with stable expression. The hNIS-U251 cell lines could intake and bind radioactive iodide by hNIS gene. The uptakes of 125 I were 117 fold higher in hNIS-U251 cell lines than U251 cell lines [(50 469.88 ± 997.29), (432.92 ± 89.28) counts·min -1 , respectively]. And the proliferation index of hNIS-U251 cell lines was lower than U251 cell lines after incubating with 131 I. Conclusion: The hNIS gene with stable gene expression (hNIS- U251) cell lines could be labeled by 131 I with a high efficiency, thereby may function effectively in the treatment of glioma-related brain tumors. (authors)

  16. Radioiodine uptake of undifferentiated thyroid cancer cells by adenovirus-mediated Na+/ I- symporter gene transfer

    Energy Technology Data Exchange (ETDEWEB)

    So, Y.; Lee, Y. J.; Shin, J. H.; Oh, H. J.; Chung, J. K.; Lee, M. C.; Cho, B. Y. [College of Medicine, Univ. of Seoul National, Seoul (Korea, Republic of); Lee, K. H. [Samsung Medical Center, Seoul (Korea, Republic of)

    2003-07-01

    To increase radioiodine uptake on undifferentiated thyroid cancer cell (ARO cells) by adenovirus-mediated human Na+/I- symporter (hNIS) gene transfer. Recombinant adenovirus Ad-hNIS was manufactured successfully. After transfecting Ad-hNIS on ARO cells, in vitro I-125 uptake and efflux studies were performed. For in vivo studies, 1.510'8 p.f.u. (50 1) of Ad-hNIS was injected into xenograft ARO tumors on the R thigh of BALB/c nu/nu mice (n=12), and same amount of normal saline was injected into xenograft ARO tumors on the L thigh. Two, 3, 4 and 6 days after intratumoral injection of Ad-hNIS, I-131 images (3 mice per day) were taken and xenograft tumors on both thighs were all excised. Total RNA was extracted from each tumor tissue and RT-PCR was performed to confirm the hNIS expression of Ad-hNIS injected xenograft ARO tumors. I-125 uptake of Ad-hNIS transfected ARO cells was increased up to 233 folds at 120 minutes in vitro. I-125 efflux study revealed rapid washout of I-125 from Ad-hNIS transfected ARO cells. On dynamic image, I-131 uptake of Ad-hNIS injected ARO tumor was continuously increased until 60 minutes. Mean count ratios of xenograft ARO tumors (R/L) of 60 minutes I-131 images at 2, 3, 4 and 6 days after Ad-hNIS injection were 2.85, 2.54, 2.31, and 2.18, each. On RT-PCR, hNIS expression of Ad-hNIS transfected ARO xenograft tumors was confirmed. Radioiodine uptake was successfully increased in ARO cells by adenovirus-mediated hNIs gene transfer both in vitro and in vivo.

  17. Internal radiotherapy of liver cancer with rat hepato-carcinoma-intestine-pancreas gene as a liver tumor-specific promoter

    Energy Technology Data Exchange (ETDEWEB)

    Herve, J.; Cunha, A. Sa; Liu, B.; Valogne, Y.; Longuet, M.; Bregerie, O.; Guettier, C.; Samuel, D.; Brechot, C.; Faivre, J. [Hop Paul Brousse, INSERM, Hepatobiliary Ctr, U785, F-94800 Villejuif (France); Herve, J.; Cunha, A. Sa; Liu, B.; Valogne, Y.; Longuet, M.; Bregerie, O.; Guettier, C.; Samuel, D.; Brechot, C.; Faivre, J. [Univ Paris Sud, Fac Med, F-94800 Villejuif (France); Boisgard, R.; Tavitian, B. [INSERM, U803, F-91400 Orsay (France); Boisgard, R.; Tavitian, B. [CEA, Serv Hosp Frederic Joliot, Lab Imagerie Mol Expt, F-91400 Orsay (France); Roux, J.; Cales, P. [Univ Angers, UPRES EA 3859, Lab Hemodynam Interact Fibrose et Invas Tumorale H, Angers (France); Clerc, J. [Hop Cochin, AP HP, Dept Nucl Med, F-75014 Paris (France)

    2008-07-01

    The hepato-carcinoma-intestine-pancreas (HIP) gene, also called pancreatitis-associated protein-1 (PAP1) or Reg III {alpha}, is activated in most human hepatocellular carcinomas (HCCs) but not in normal liver, which suggests that HIP regulatory sequence could be used as efficient liver tumor-specific promoters to express a therapeutic polynucleotide in liver cancer. The sodium iodide sym-porter (NIS), which has recognized therapeutic and reporter gene properties, is appropriate to evaluate the transcriptional strength and specificity of the HIP promoter in HCC. For this purpose, we constructed a recombinant rat HIP-NIS adeno-viral vector (AdrHIP-NIS), and evaluated its performance as a mediator of selective radio-iodide uptake in tumor hepatocytes. Western blot, immunofluorescence, and iodide uptake assays were performed in AdrHIP-NIS-infected primary hepatocytes and transformed hepatic and non-hepatic cells. Nuclear imaging, tissue counting and immuno-histo-chemistry were performed in normal and HCC-bearing Wistar rats infected with AdrHIP-NIS intra-tumorally or via the hepatic artery. In AdrHIP-NIS-infected transformed hepatic cells, functional NIS was strongly expressed, as in cells infected with a cytomegalovirus-NIS vector. No NIS expression was found in AdrHIP-NIS-infected normal hepatocytes or transformed non-hepatic cells. In rats bearing multi-nodular HCC, AdrHIP-NIS triggered functional NIS expression that was preferential in tumor hepatocytes. Administration of 18 mCi of {sup 131}I resulted in the destruction of AdrHIP-NIS-injected nodules. This study has identified the rHIP regulatory sequence as a potent liver tumor-specific promoter for the transfer of therapeutic genes, and AdrHIP-NIS-mediated. {sup 131}I therapy as a valuable option for the treatment of multi-nodular HCC. (authors)

  18. Internal radiotherapy of liver cancer with rat hepato-carcinoma-intestine-pancreas gene as a liver tumor-specific promoter

    International Nuclear Information System (INIS)

    Herve, J.; Cunha, A. Sa; Liu, B.; Valogne, Y.; Longuet, M.; Bregerie, O.; Guettier, C.; Samuel, D.; Brechot, C.; Faivre, J.; Herve, J.; Cunha, A. Sa; Liu, B.; Valogne, Y.; Longuet, M.; Bregerie, O.; Guettier, C.; Samuel, D.; Brechot, C.; Faivre, J.; Boisgard, R.; Tavitian, B.; Boisgard, R.; Tavitian, B.; Roux, J.; Cales, P.; Clerc, J.

    2008-01-01

    The hepato-carcinoma-intestine-pancreas (HIP) gene, also called pancreatitis-associated protein-1 (PAP1) or Reg III α, is activated in most human hepatocellular carcinomas (HCCs) but not in normal liver, which suggests that HIP regulatory sequence could be used as efficient liver tumor-specific promoters to express a therapeutic polynucleotide in liver cancer. The sodium iodide sym-porter (NIS), which has recognized therapeutic and reporter gene properties, is appropriate to evaluate the transcriptional strength and specificity of the HIP promoter in HCC. For this purpose, we constructed a recombinant rat HIP-NIS adeno-viral vector (AdrHIP-NIS), and evaluated its performance as a mediator of selective radio-iodide uptake in tumor hepatocytes. Western blot, immunofluorescence, and iodide uptake assays were performed in AdrHIP-NIS-infected primary hepatocytes and transformed hepatic and non-hepatic cells. Nuclear imaging, tissue counting and immuno-histo-chemistry were performed in normal and HCC-bearing Wistar rats infected with AdrHIP-NIS intra-tumorally or via the hepatic artery. In AdrHIP-NIS-infected transformed hepatic cells, functional NIS was strongly expressed, as in cells infected with a cytomegalovirus-NIS vector. No NIS expression was found in AdrHIP-NIS-infected normal hepatocytes or transformed non-hepatic cells. In rats bearing multi-nodular HCC, AdrHIP-NIS triggered functional NIS expression that was preferential in tumor hepatocytes. Administration of 18 mCi of 131 I resulted in the destruction of AdrHIP-NIS-injected nodules. This study has identified the rHIP regulatory sequence as a potent liver tumor-specific promoter for the transfer of therapeutic genes, and AdrHIP-NIS-mediated. 131 I therapy as a valuable option for the treatment of multi-nodular HCC. (authors)

  19. The sodium iodide symporter: its implications for imaging and therapy

    International Nuclear Information System (INIS)

    Spitzweg, C.

    2007-01-01

    The sodium iodide symporter (NIS) is an intrinsic plasma membrane glycoprotein that mediates the active transport of iodide in the thyroid gland and a number of extrathyroidal tissues, in particular lactating mammary gland. In addition to its key function in thyroid physiology, NIS-mediated iodide accumulation allows diagnostic thyroid scintigraphy as well as therapeutic radioiodine application in benign and malignant thyroid disease. NIS therefore represents one of the oldest targets for molecular imaging and therapy. Based on the effective administration of radioiodine that has been used for over 60 years in the management of follicular cell-derived thyroid cancer, cloning and characterization of the NIS gene has paved the way for the development of a novel cytoreductive gene therapy strategy based on targeted NIS expression in thyroidal and nonthyroidal cancer cells followed by therapeutic application of 131 I or alternative radionuclides, including 188 Re and 211 At. In addition, the possibility of direct and non-invasive imaging of functional NIS expression by 123 I- and 99m Tc-scintigraphy or 124 I-PET-imaging allows the application of NIS as a novel reporter gene. In conclusion, the dual role of NIS as diagnostic and therapeutic gene and the detection of extra-thyroidal endogenous NIS expression in breast cancer open promising perspectives in nuclear medicine and molecular oncology for diagnostic and therapeutic application of NIS outside the thyroid gland. (orig.)

  20. Expression of sodium/iodide symporter transgene in neural stem cells

    International Nuclear Information System (INIS)

    Kim, Yun Hui; Lee, Dong Soo; Kang, Joo Hyun; Lee, Yong Jin; Chung, June Key; Lee, Myung Chul

    2004-01-01

    The ability to noninvasively track the migration of neural progenitor cells would have significant clinical and research implications. We generated stably transfected F3 human neural progenitor cells with human sodium/iodide symporter (hNIS) for noninvasively tracking F3. In this study, the expression patterns of hNIS gene in F3-NIS were examined according to the cultured time and the epigenetic modulation. F3 human neural stem cells had been obtained from Dr. Seung U. Kim (Ajou University, Suwon, Korea). hNIS and hygromycin resistance gene were linked with IRES (internal Ribosome Entry Site) under control of CMV promoter. This construct was transfected to F3 with Liposome. To investigate the restoration of hNIS gene expression in F3-NIS, cells were treated with demethylating agent (5-Azacytidine) and Histone deacetylase inhibitor (Trichostatin A: TSA). The expression of hNIS was measured by I-125 uptake assay and RT-PCR analysis. The iodide uptake of the F3-NIS was higher 12.86 times than F3 cell line. According to the cell passage number, hNIS expression in F3-NIS gradually diminished. After treatment of 5-Azacytidine and TSA with serial doses (up to 20μM, up to 62.5nM, respectively) for 24 hours, I-125 uptake and mRNA of hNIS in F3-NIS were increased. These results suggest that hNIS transfected F3 might undergo a change in its biological characters by cell passage. Therefore, the gene expression of exogenous gene transferred human stem cell might be affected to the epigenetic modulation such as promoter methylation and Histone deacetylation and to the cell culture conditions

  1. Mechanisms and Functions within a National Innovation System

    Directory of Open Access Journals (Sweden)

    Joseph Gogodze

    2016-12-01

    Full Text Available In modern society, the competitive success of countries is increasingly dependent on the effective management of their national innovation system (NIS. Therefore, understanding the mechanisms behind NISs has become essential. After reviewing the current understanding of the NIS concept and the existing measurement models, this study proposes to consider the NIS as an intangible (underlying asset of a specific kind and identifies its seven fundamental components, which are extracted with a new measurement model, the Global Innovation Index (GII. This study employs the Structural Equation Modeling (SEM techniques to analyze the relationships among the components of an NIS. Our results support the existence of a causal link between the constituents of an NIS and provide several perspectives regarding NIS management opportunities. In particular, we find that the efficient management of institutional capital is a key determinant of innovation success for non-high-income countries.

  2. Small-molecule inhibitors of sodium iodide sym-porter function

    International Nuclear Information System (INIS)

    Lecat-Guillet, N.; Merer, G.; Lopez, R.; Rousseau, B.; Ambroise, Y.; Pourcher, T.

    2008-01-01

    The Na + /l - sym-porter (NIS) mediates iodide uptake into thyroid follicular cells. Although NIS has been cloned and thoroughly studied at the molecular level, the biochemical processes involved in post-translational regulation of NIS are still unknown. The purpose of this study was to identify and characterize inhibitors of NIS function. These small organic molecules represent a starting point in the identification of pharmacological tools for the characterization of NIS trafficking and activation mechanisms. screening of a collection of 17020 drug-like compounds revealed new chemical inhibitors with potencies down to 40 nM. Fluorescence measurement of membrane potential indicates that these inhibitors do not act by disrupting the sodium gradient. They allow immediate and total iodide discharge from preloaded cells in accord with a specific modification of NIS activity, probably through distinct mechanisms. (authors)

  3. Small-molecule inhibitors of sodium iodide sym-porter function

    Energy Technology Data Exchange (ETDEWEB)

    Lecat-Guillet, N.; Merer, G.; Lopez, R.; Rousseau, B.; Ambroise, Y. [CEA, DSV, Dept Bioorgan Chem et Isotop Labelling, Inst Biol et Biotechnol iBiTecS, F-91191 Gif Sur Yvette (France); Pourcher, T. [Univ Nice Sophia Antipolis, Dept Biochem et Nucl Toxicol, F-06107 Nice (France)

    2008-07-01

    The Na{sup +}/l{sup -} sym-porter (NIS) mediates iodide uptake into thyroid follicular cells. Although NIS has been cloned and thoroughly studied at the molecular level, the biochemical processes involved in post-translational regulation of NIS are still unknown. The purpose of this study was to identify and characterize inhibitors of NIS function. These small organic molecules represent a starting point in the identification of pharmacological tools for the characterization of NIS trafficking and activation mechanisms. screening of a collection of 17020 drug-like compounds revealed new chemical inhibitors with potencies down to 40 nM. Fluorescence measurement of membrane potential indicates that these inhibitors do not act by disrupting the sodium gradient. They allow immediate and total iodide discharge from preloaded cells in accord with a specific modification of NIS activity, probably through distinct mechanisms. (authors)

  4. Rezension: Ada Lovelace. Die Pionierin der Computertechnik und ihre Nachfolgerinnen von Sybille Krämer (Hg.)

    OpenAIRE

    Bettina Schabschneider

    2015-01-01

    Ein aktueller von Sybille Krämer herausgegebener Sammelband beleuchtet die Bedeutung der Computertechnik-Pionierin Ada Lovelace. Bettina Schabschneider hat den Band einer detaillierten Lektüre unterzogen und für die MEDIENIMPULSE rezensiert …

  5. Nuclear material accounting and control: Co-ordinating assistance to newly independent States

    International Nuclear Information System (INIS)

    Thorstensen, S.

    1995-01-01

    This article outlines work under way among the IAEA, its Member States, and the Newly Independent States (NIS) relating to the establishment and development in the NIS of State Systems of Accounting and Control (SSACs) of nuclear material. It describes IAEA activities in the NIS, including fact-finding missions at technical visits, the successful attempts to find donor States providing voluntary funding and expertise, and the co-ordination of technical support between the IAEA and the donor States. 3 tabs

  6. Evaluation of transcriptional activity of the oestrogen receptor with sodium iodide symporter as an imaging reporter gene.

    Science.gov (United States)

    Kang, Joo Hyun; Chung, June-Key; Lee, Yong Jin; Kim, Kwang Il; Jeong, Jae Min; Lee, Dong Soo; Lee, Myung Chul

    2006-10-01

    Oestrogen receptors are ligand-dependent transcription factors whose activity is modulated either by oestrogens or by an alternative signalling pathway. Oestrogen receptors interact via a specific DNA-binding domain, the oestrogen responsive element (ERE), in the promoter region of sensitive genes. This binding leads to an initiation of gene expression and hormonal effects. To determine the transcriptional activity of the oestrogen receptor, we developed a molecular imaging system using sodium iodide symporter (NIS) as a reporter gene. The NIS reporter gene was placed under the control of an artificial ERE derived from pERE-TA-SEAP and named as pERE-NIS. pERE-NIS was transferred to MCF-7, human breast cancer cells, which highly expressed oestrogen receptor-alpha with lipofectamine. Stably expressing cells were generated by selection with G418 for 14 days. After treatment of 17beta-oestradiol and tamoxifen with serial doses, the (125)I uptake was measured for the determination of NIS expression. The inhibition of NIS activity was performed with 50 micromol x l(-1) potassium perchlorate. The MCF7/pERE-NIS treated with 17beta-oestradiol accumulated (125)I up to 70-80% higher than did non-treated cells. NIS expression was increased according to increasing doses of 17beta-oestradiol. MCF7/pERE-NIS treated with tamoxifen also accumulated (125)I up to 50% higher than did non-treated cells. Potassium perchlorate completely inhibited (125)I uptake. When MDA-MB231 cells, the oestrogen receptor-negative breast cancer cells, were transfected with pERE-NIS, (125)I uptake of MDA-MB-231/pERE-NIS did not increase. This pERE-NIS reporter system is sufficiently sensitive for monitoring transcriptional activity of the oestrogen receptor. Therefore, cis-enhancer reporter systems with ERE will be applicable to the development of a novel selective oestrogen receptor modulator with low toxicity and high efficacy.

  7. CD31-Expression am Primärtumor und Nachweis hämatogen disseminierter Tumorzellen im Knochenmark von Brustkrebspatientinnen

    OpenAIRE

    Eisenmann, Petra

    2005-01-01

    Der Nachweis von disseminierten Tumorzellen im Knochenmark von Patientinnen mit primärem Mammakarzinom ist ein wichtiger prognostischer Parameter. In der vorliegenden Arbeit wurde der Nachweis von CD31 am Primärtumor Mammakarzinom mit dem Auftreten von Mikrometastasen im Knochenmark korreliert. Ferner wurde die prognostische Bedeutung von disseminierten Tumorzellen im Knochenmark und die prognostische Bedeutung von CD31 evaluiert. Bei 50 Patientinnen des Gesamtkollektivs von 195 (25,6%) wu...

  8. Produktherkunft und Preis als Einflussfaktoren auf die Kaufentscheidung

    OpenAIRE

    Leitow, Detmar

    2005-01-01

    Vor dem Hintergrund gesättigter und informationsüberlasteter Märkte wird die Bedeutung der regionalen Herkunft von Lebensmitteln für das Konsumentenverhalten diskutiert. Obwohl diesem Produktattribut in wissenschaftlichen Befragungen eine marketingrelevante Bedeutung bescheinigt wird, spiegelt sich die geäußerte Präferenz und Mehrpreisbereitschaft aus Sicht des Einzelhandels häufig nicht im Kaufverhalten wider. Dies deutet auf eine Diskrepanz zwischen der Einstellung und dem Verhalten hin. Zi...

  9. National systems of innovation: determinants and industrial policy measures, empirical evidence for OECD; Sistemas nacionales de innovacion: determinantes y acciones de politica industrial. Evidencia empirica para la OCDE

    Energy Technology Data Exchange (ETDEWEB)

    Hervas, J. L.; Rojas, R.; Sempere, F.; Albors, J.

    2012-11-01

    The paper presents an attempt to tackle the main gaps in the national innovation systems (NIS) literature: the problem specifying the boundaries of the NIS and the lack of connection between theory and empirics. For this purpose, the paper uses 55 countries as sample and constructs an NIS index based on a factor analysis of 28 variables. Empirical evidence shows that a firm's strategies, technology infrastructure, government governance, education and linkages are the main components of the NIS. The implications are important for policy-makers and the academia. (Author) 49 refs.

  10. Dicty_cDB: CFI277 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available nslated Amino Acid sequence (All Frames) Frame A: ---xxxxxxxxxxxxxnxxxxxxkgxxxxxkxxxxkxyxxxxqxkx*cnxknrixtfn...NKTPVKPKLGEYG QKSIKTK Frame C: ---xxxxxxxxxxxxqxxxxxxxrxxxxxkxlxxqxixxxsxxqtxmq*xk*nxhfqslq ingsspxq*nis*vsa

  11. Alpha-lipoic acid induces sodium iodide symporter expression in TPC-1 thyroid cancer cell line

    International Nuclear Information System (INIS)

    Choi, Hyun-Jeung; Kim, Tae Yong; Ruiz-Llorente, Sergio; Jeon, Min Ji; Han, Ji Min; Kim, Won Gu; Shong, Young Kee; Kim, Won Bae

    2012-01-01

    Introduction: Patients with metastatic thyroid cancers that do not uptake iodine need effective therapeutic option. Differentiation-inducing agents have been tried to restore functional expression of sodium iodide symporter (NIS) without success. Our objective was to assess the effect of alpha-lipoic acid (ALA), known as potential antioxidant, on expression of sodium iodide symporter in thyroid cancer cells. Methods: Human thyroid cancer-derived cell lines, TPC-1, were treated with ALA, and changes in NIS mRNA and protein expression were measured. ALA's effect on NIS gene promoter was evaluated, and functional NIS expression was assessed by iodide uptake assay. Results: Treatment with ALA increased NIS mRNA expression up to ten folds of control dose-dependently after 24 h of exposure. ALA increased NIS promoter activity, and increased iodide uptake by 1.6 fold. ALA induced expression of NIS protein, but had no significant effect on the plasma membrane trafficking. ALA increased phosphorylation of CREB and nuclear translocation of pCREB, and co-treatment of ALA and trichostatin A increased iodide uptake by three folds in TPC-1 cells. Conclusions: ALA is a potential agent to increase NIS transcription in TPC-1. It could be used as an adjunctive agent to increase efficacy of radioiodine therapy if combined with a strategy to increase NIS protein trafficking to cell membrane.

  12. Dicty_cDB: Contig-U08241-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available XIXXXXXXKXXXXXXKXXXXNXXXXFXXXNXDAIXKIEXPLSIP SNQWFFSXPIKHIMSFSPTYGTPSKIIDSPSKLLNTPKKKQQDKTNKTNKTPVKPKLGEY GQKSIKTK Frame B: xxxxxxxxx...xxxxxxxqxxxxxxxrxxxxxkxlxxqxixxxsxxqtxmq*xk*nxhfqsl qingsspxq*nis*vsaqxmvhhrklsihqv...nc*thqkrnnktkqtrptkhqsnqnwvnm dkka*kq Frame C: xxxxxxxxxxxxxxxxnxxxxxxkgxxxxxkxxxxkxyxxxx

  13. National innovation system in less successful developing countries

    DEFF Research Database (Denmark)

    Intarakumnerd, Patarapong; Chairatana, Pun-arj; Tangchitpiboon, Tipawan

    2002-01-01

    This paper, using Thailand as a case study, aims at understanding the national innovation system (NIS) in developing countries which are less successful in technological catching-up. In contrast to developed countries, the development level of Thailand’s NIS does not link to its economic structural...... development level. As Thailand moves from agricultural to an increasingly industrial economy, its NIS remains weak and fragmented. The mismatch between the two affected Thailand’s competitiveness and partially contributed to the recent economic crisis. Studies of NIS in countries like Thailand should focus...

  14. Surface-enhanced Raman scattering biosensor for DNA detection on nanoparticle island substrates

    DEFF Research Database (Denmark)

    Yuan, Scott Wu; Ho, Ho Pui; Lee, Rebecca K.Y.

    2009-01-01

    We present a study on the surface-enhanced Raman scattering (SERS) properties of Ag nanoparticle island substrates (NIS) and their applications for target oligonucleotide (OND) detection. It has been found that the surface nanostructure of NIS samples can be controlled with a good degree of repro......We present a study on the surface-enhanced Raman scattering (SERS) properties of Ag nanoparticle island substrates (NIS) and their applications for target oligonucleotide (OND) detection. It has been found that the surface nanostructure of NIS samples can be controlled with a good degree...

  15. Infrastructure design & road safety : OECD Workshop B3 (Infrastructure design and road safety) for CEE's and NIS held on 15th-18th November 1994, Prague (Czech Republic). Part 1: Summaries, conclusions and recommendations, and statements from Central and Eastern European countries.

    NARCIS (Netherlands)

    2012-01-01

    The workshop 'Infrastructure design and road safety ' was one of the initiatives which the OECO Steering Committee for Road Transport Research developed with the aim of exchanging information in the road transport sector, in order to respond to the urgent needs expressed by Central and Eastern

  16. A massive update of non-indigenous species records in Mediterranean marinas.

    Science.gov (United States)

    Ulman, Aylin; Ferrario, Jasmine; Occhpinti-Ambrogi, Anna; Arvanitidis, Christos; Bandi, Ada; Bertolino, Marco; Bogi, Cesare; Chatzigeorgiou, Giorgos; Çiçek, Burak Ali; Deidun, Alan; Ramos-Esplá, Alfonso; Koçak, Cengiz; Lorenti, Maurizio; Martinez-Laiz, Gemma; Merlo, Guenda; Princisgh, Elisa; Scribano, Giovanni; Marchini, Agnese

    2017-01-01

    The Mediterranean Sea is home to over 2/3 of the world's charter boat traffic and hosts an estimated 1.5 million recreational boats. Studies elsewhere have demonstrated marinas as important hubs for the stepping-stone transfer of non-indigenous species (NIS), but these unique anthropogenic, and typically artificial habitats have largely gone overlooked in the Mediterranean as sources of NIS hot-spots. From April 2015 to November 2016, 34 marinas were sampled across the following Mediterranean countries: Spain, France, Italy, Malta, Greece, Turkey and Cyprus to investigate the NIS presence and richness in the specialized hard substrate material of these marina habitats. All macroinvertebrate taxa were collected and identified. Additionally, fouling samples were collected from approximately 600 boat-hulls from 25 of these marinas to determine if boats host diverse NIS not present in the marina. Here, we present data revealing that Mediterranean marinas indeed act as major hubs for the transfer of marine NIS, and we also provide evidence that recreational boats act as effective vectors of spread. From this wide-ranging geographical study, we report here numerous new NIS records at the basin, subregional, country and locality level. At the basin level, we report three NIS new to the Mediterranean Sea ( Achelia sawayai sensu lato , Aorides longimerus , Cymodoce aff. fuscina ), and the re-appearance of two NIS previously known but currently considered extinct in the Mediterranean ( Bemlos leptocheirus, Saccostrea glomerata ). We also compellingly update the distributions of many NIS in the Mediterranean Sea showing some recent spreading; we provide details for 11 new subregional records for NIS ( Watersipora arcuata , Hydroides brachyacantha sensu lato and Saccostrea glomerata now present in the Western Mediterranean; Symplegma brakenhielmi , Stenothoe georgiana , Spirobranchus tertaceros sensu lato , Dendostrea folium sensu lato and Parasmittina egyptiaca now present in

  17. PI3K activation is associated with intracellular sodium/iodide symporter protein expression in breast cancer

    International Nuclear Information System (INIS)

    Knostman, Katherine AB; McCubrey, James A; Morrison, Carl D; Zhang, Zhaoxia; Capen, Charles C; Jhiang, Sissy M

    2007-01-01

    The sodium/iodide symporter (NIS) is a membrane glycoprotein mediating active iodide uptake in the thyroid gland and is the molecular basis for radioiodide imaging and therapeutic ablation of thyroid carcinomas. NIS is expressed in the lactating mammary gland and in many human breast tumors, raising interest in similar use for diagnosis and treatment. However, few human breast tumors have clinically evident iodide uptake ability. We previously identified PI3K signaling as important in NIS upregulation in transgenic mouse models of breast cancer, and the PI3K pathway is commonly activated in human breast cancer. NIS expression, subcellular localization, and function were analyzed in MCF-7 human breast cancer cells and MCF-7 cells stably or transiently expressing PI3K p110alpha subunit using Western blot of whole cell lysate, cell surface biotinylation Western blot and immunofluorescence, and radioiodide uptake assay, respectively. NIS localization was determined in a human breast cancer tissue microarray using immunohistochemical staining (IHC) and was correlated with pre-existing pAkt IHC data. Statistical analysis consisted of Student's t-test (in vitro studies) or Fisher's Exact Test (in vivo correlational studies). In this study, we demonstrate that PI3K activation in MCF-7 human mammary carcinoma cells leads to expression of underglycosylated NIS lacking cell surface trafficking necessary for iodide uptake ability. PI3K activation also appears to interfere with cell surface trafficking of exogenous NIS as well as all-trans retinoic acid-induced endogenous NIS. A correlation between NIS expression and upregulation of PI3K signaling was found in a human breast cancer tissue microarray. Thus, the PI3K pathway likely plays a major role in the discordance between NIS expression and iodide uptake in breast cancer patients. Further study is warranted to realize the application of NIS-mediated radioiodide ablation in breast cancer

  18. 1,25-(OH)2-vitamin D3 enhances the cytotoxic effect of radioiodine therapy in prostate cancer cells expressing the sodium iodide symporter

    International Nuclear Information System (INIS)

    Spitzweg, Christine; Hirschmann, Martin; Unterholzner, Stefanie; Cengic, Neziha; Eckel, Petra; Sharif-Samani, Bibi-Rana; Willhauck, Michael J.; Goeke, Burkhard; Morris, John C.

    2005-01-01

    Full text: We reported recently the induction of androgen-dependent iodide uptake activity in human prostate cancer cells (LNCaP) utilizing a prostate-specific antigen (PSA)-promoter directed expression of the sodium iodide symporter (NIS) gene. This offers the potential to treat prostate cancer with radioiodine. In the current study we examined the regulation of PSA-promoter directed NIS expression and therapeutic effectiveness of 131 I in LNCaP cells by 1,25-(OH)2-Vitamin D3 (Vit D3). For this purpose, NIS mRNA and protein expression levels in the NIS-transfected LNCaP cell line NP-1 were examined by Northern and Western blot analysis following incubation with Vit D3 (10 -9 M - 10 -5 M) in the presence of mibolerone (10 -9 M). In addition, NIS functional activity was measured by iodide uptake assay, and in vitro cytotoxicity of 131 I was examined by in vitro clonogenic assay. Following incubation with Vit D3, NIS mRNA levels in NP-1 cells were stimulated 1.2-fold, whereas NIS protein levels increased 1.65-fold and iodide accumulation was stimulated 1.4-fold in a concentration-dependent manner. Further, the selective killing effect of 131 I in NP-1 cells was significantly increased from 55% in NP-1 cells incubated with mibolerone alone to 86 % in NP-1 cells treated with Vit D3 (10 -5 M) in the presence of mibolerone. In the absence of androgen, with or without Vit D3 no functional NIS expression was detected. Conclusion: Treatment with Vit D3 increases androgen-induced NIS expression levels and selective killing effect of 131 I in prostate cancer cells stably expressing NIS under the control of the PSA promoter. Vit D3 may therefore be used to enhance the therapeutic response to radioiodine in prostate cancer cells following PSA-promoter directed NIS gene delivery. (author)

  19. International arrivals: widespread bioinvasions in European Seas.

    Science.gov (United States)

    Galil, B S; Marchini, A; Occhipinti-Ambrogi, A; Minchin, D; Narščius, A; Ojaveer, H; Olenin, S

    2014-04-01

    The European Union lacks a comprehensive framework to address the threats posed by the introduction and spread of marine non-indigenous species (NIS). Current efforts are fragmented and suffer substantial gaps in coverage. In this paper we identify and discuss issues relating to the assessment of spatial and temporal patterns of introductions in European Seas (ES), based on a scientifically validated information system of aquatic non-indigenous and cryptogenic species, AquaNIS. While recognizing the limitations of the existing data, we extract information that can be used to assess the relative risk of introductions for different taxonomic groups, geographic regions and likely vectors. The dataset comprises 879 multicellular NIS. We applied a country-based approach to assess patterns of NIS richness in ES, and identify the principal introduction routes and vectors, the most widespread NIS and their spatial and temporal spread patterns. Between 1970 and 2013, the number of recorded NIS has grown by 86, 173 and 204% in the Baltic, Western European margin and the Mediterranean, respectively; 52 of the 879 NIS were recorded in 10 or more countries, and 25 NIS first recorded in European seas since 1990 have since been reported in five or more countries. Our results highlight the ever-rising role of shipping (commercial and recreational) as a vector for the widespread and recently spread NIS. The Suez Canal, a corridor unique to the Mediterranean, is responsible for the increased introduction of new thermophilic NIS into this warming sea. The 2020 goal of the EU Biodiversity Strategy concerning marine Invasive Alien Species may not be fully attainable. The setting of a new target date should be accompanied by scientifically robust, sensible and pragmatic plans to minimize introductions of marine NIS and to study those present.

  20. Information Quality of a Nursing Information System depends on the nurses: A combined quantitative and qualitative evaluation

    NARCIS (Netherlands)

    Michel-Verkerke, M.B.

    2012-01-01

    Purpose Providing access to patient information is the key factor in nurses’ adoption of a Nursing Information System (NIS). In this study the requirements for information quality and the perceived quality of information are investigated. A teaching hospital in the Netherlands has developed a NIS as

  1. Utilizing Graphics Processing Units for Network Anomaly Detection

    Science.gov (United States)

    2012-09-13

    pages 1266–1271, 2003. [Nis12a] Ste↵en Nissen. Fann datatypes - activation function enum, 2012. http://leenissen.dk/fann/html/files/fann data-h.html# fann...activationfunc enum. Last accessed: 7 Aug 2012. [Nis12b] Ste↵en Nissen. Fann datatypes - train enum, 2012. http://leenissen.dk/fann/html/files/fann

  2. Time-course investigation of infection with a low virulent Pasteurella multocida strain in normal and immune-suppressed 12-week-old free-range chickens

    DEFF Research Database (Denmark)

    Mbuthia, P.G.; Njagi, L.W.; Nyaga, P.N.

    2011-01-01

    Twelve-week-old indigenous chickens, either immune-suppressed using dexamethasone (IS) or non-immune-suppressed (NIS), were challenged with a low virulent strain, Pasteurella multocida strain NCTC 10322(T), and developed clinical signs and pathological lesions typical of chronic fowl cholera. NIS...

  3. A Model of the Costs of Community and Nosocomial Pediatric Respiratory Syncytial Virus Infections in Canadian Hospitals

    Directory of Open Access Journals (Sweden)

    Philip Jacobs

    2013-01-01

    Full Text Available BACKGROUND: Approximately one in 10 hospitalized patients will acquire a nosocomial infection (NI after admission to hospital, of which 71% are due to respiratory viruses, including the respiratory syncytial virus (RSV. NIs are concerning and lead to prolonged hospitalizations. The economics of NIs are typically described in generalized terms and specific cost data are lacking.

  4. Attitudinal and behavioral differences between cigarette users who do and do not identify as "smokers".

    Science.gov (United States)

    Berg, Michael B; Lin, Linda; White, Madeleine; Alfonso-Barry, Jacqueline

    2017-01-01

    The current research aimed to understand differences in smoking-related identity among college students and to illustrate the distinct characteristics of nonidentified smokers (NIS). Students from 2 colleges in Massachusetts (N = 538; April 2016). Respondents reported by online survey whether or not they had smoked a cigarette in the past 30 days and if they self-identified as smokers. Nonsmokers (NIS) and identified smokers (IS) were then compared on their smoking attitudes and behavior. NIS made up 12.5% of the sample and 64% of all tobacco users. NIS perceived themselves as less addicted and were more confident in their ability to quit smoking. They also were less likely to smoke alone, buy their own cigarettes, or have friends who smoked. College health officials can best motivate NIS to quit smoking by focusing on peer norms and the potential of long-term addiction.

  5. Dynamic iodide trapping by tumor cells expressing the thyroidal sodium iodide symporter

    International Nuclear Information System (INIS)

    Dingli, David; Bergert, Elizabeth R.; Bajzer, Zeljko; O'Connor, Michael K.; Russell, Stephen J.; Morris, John C.

    2004-01-01

    The thyroidal sodium iodide symporter (NIS) in combination with various radioactive isotopes has shown promise as a therapeutic gene in various tumor models. Therapy depends on adequate retention of the isotope in the tumor. We hypothesized that in the absence of iodide organification, isotope trapping is a dynamic process either due to slow efflux or re-uptake of the isotope by cells expressing NIS. Iodide efflux is slower in ARH-77 and K-562 cells expressing NIS compared to a thyroid cell line. Isotope retention half times varied linearly with the number of cells expressing NIS. With sufficient NIS expression, iodide efflux is a zero-order process. Efflux kinetics in the presence or absence of perchlorate also supports the hypothesis that iodide re-uptake occurs and contributes to the retention of the isotope in tumor cells. Iodide organification was insignificant. In vivo studies in tumors composed of mixed cell populations confirmed these observations

  6. Clinical value of sodium iodide symporter

    International Nuclear Information System (INIS)

    Li Qian

    2003-01-01

    The sodium iodide symptorter (NIS) is a membrane glycoprotein that mediates iodide uptake in the thyroid gland and several extrathyroidal tissues. In addition to thyroid tissues, the expression of NIS is found in stomach, prostate, placenta and so on. Radioiodine-concentrating activity in thyroid tissues has allowed the use of radioiodine as a diagnostic and therapeutic agent for patients with thyroid disorders. However, some extrathyroid tissues also take up radioiodine, contributing to unwanted side effects of radioiodine therapy. Now that the molecule of NIS has been cloned and characterized, it may be possible to develop novel strategies to differentially modulate NIS expression and activity, enhancing it in target tissues and impeding it in others. It is also important to explore the use of NIS as an imaging reporter gene to monitor the expression profile of the transgene in transgenic mouse animal models and in patients undergoing gene therapy clinical trials

  7. Shaping a holistic national innovation system. Riigi tervikliku innovatsioonisüsteemi kujundamine

    Directory of Open Access Journals (Sweden)

    Janno Reiljan

    2016-08-01

    Full Text Available For the sustainable economic development of a state the functioning national innovation system (NIS is needed. NIS covers different government policies (for instance, education policy, R&D policy innovation support to business sector, intellectual property protection, public procurement policy, etc.. All these policies have to be integrated in a holistic system through innovation policy enabling the functioning different policies in mutual relationships smoothly and effectively for sustainable economic development. The goal of this article is to highlight the role of innovation policy in shaping a holistic NIS. The first part of the article deals with the need for public sector intervention in innovation processes and problems resulting from it. In the second part a holistic NIS model that reflects the role of innovation policy is developed and presented. The third part deals with the structure of innovation policy based on a holistic NIS model

  8. Linking loss of sodium-iodide symporter expression to DNA damage

    International Nuclear Information System (INIS)

    Lyckesvärd, Madeleine Nordén; Kapoor, Nirmal; Ingeson-Carlsson, Camilla; Carlsson, Therese; Karlsson, Jan-Olof; Postgård, Per; Himmelman, Jakob; Forssell-Aronsson, Eva; Hammarsten, Ola; Nilsson, Mikael

    2016-01-01

    Radiotherapy of thyroid cancer with I-131 is abrogated by inherent loss of radioiodine uptake due to loss of sodium iodide symporter (NIS) expression in poorly differentiated tumor cells. It is also known that ionizing radiation per se down-regulates NIS (the stunning effect), but the mechanism is unknown. Here we investigated whether loss of NIS-mediated iodide transport may be elicited by DNA damage. Calicheamicin, a fungal toxin that specifically cleaves double-stranded DNA, induced a full scale DNA damage response mediated by the ataxia-telangiectasia mutated (ATM) kinase in quiescent normal thyrocytes. At sublethal concentrations (<1 nM) calicheamicin blocked NIS mRNA expression and transepithelial iodide transport as stimulated by thyrotropin; loss of function occurred at a much faster rate than after I-131 irradiation. KU-55933, a selective ATM kinase inhibitor, partly rescued NIS expression and iodide transport in DNA-damaged cells. Prolonged ATM inhibition in healthy cells also repressed NIS-mediated iodide transport. ATM-dependent loss of iodide transport was counteracted by IGF-1. Together, these findings indicate that NIS, the major iodide transporter of the thyroid gland, is susceptible to DNA damage involving ATM-mediated mechanisms. This uncovers novel means of poor radioiodine uptake in thyroid cells subjected to extrinsic or intrinsic genotoxic stress. - Highlights: • DNA damage inhibits polarized iodide transport in normal thyroid cells. • Down-regulation of NIS expression is mediated by activation of the ATM kinase. • Long-term ATM inhibition also represses NIS-mediated iodide transport. • IGF-1 rescues NIS expression and iodide transport in DNA-damaged cells.

  9. Linking loss of sodium-iodide symporter expression to DNA damage

    Energy Technology Data Exchange (ETDEWEB)

    Lyckesvärd, Madeleine Nordén [Sahlgrenska Cancer Center, University of Gothenburg, Göteborg (Sweden); Department of Medical Chemistry and Cell Biology, University of Gothenburg, Göteborg (Sweden); Kapoor, Nirmal [Department of Medical Chemistry and Cell Biology, University of Gothenburg, Göteborg (Sweden); Ingeson-Carlsson, Camilla; Carlsson, Therese [Sahlgrenska Cancer Center, University of Gothenburg, Göteborg (Sweden); Department of Medical Chemistry and Cell Biology, University of Gothenburg, Göteborg (Sweden); Karlsson, Jan-Olof [Department of Medical Chemistry and Cell Biology, University of Gothenburg, Göteborg (Sweden); Postgård, Per; Himmelman, Jakob; Forssell-Aronsson, Eva [Department of Radiation Physics, University of Gothenburg, Göteborg (Sweden); Hammarsten, Ola [Department of Clinical Chemistry, University of Gothenburg, Göteborg (Sweden); Nilsson, Mikael, E-mail: mikael.nilsson@gu.se [Sahlgrenska Cancer Center, University of Gothenburg, Göteborg (Sweden); Department of Medical Chemistry and Cell Biology, University of Gothenburg, Göteborg (Sweden)

    2016-05-15

    Radiotherapy of thyroid cancer with I-131 is abrogated by inherent loss of radioiodine uptake due to loss of sodium iodide symporter (NIS) expression in poorly differentiated tumor cells. It is also known that ionizing radiation per se down-regulates NIS (the stunning effect), but the mechanism is unknown. Here we investigated whether loss of NIS-mediated iodide transport may be elicited by DNA damage. Calicheamicin, a fungal toxin that specifically cleaves double-stranded DNA, induced a full scale DNA damage response mediated by the ataxia-telangiectasia mutated (ATM) kinase in quiescent normal thyrocytes. At sublethal concentrations (<1 nM) calicheamicin blocked NIS mRNA expression and transepithelial iodide transport as stimulated by thyrotropin; loss of function occurred at a much faster rate than after I-131 irradiation. KU-55933, a selective ATM kinase inhibitor, partly rescued NIS expression and iodide transport in DNA-damaged cells. Prolonged ATM inhibition in healthy cells also repressed NIS-mediated iodide transport. ATM-dependent loss of iodide transport was counteracted by IGF-1. Together, these findings indicate that NIS, the major iodide transporter of the thyroid gland, is susceptible to DNA damage involving ATM-mediated mechanisms. This uncovers novel means of poor radioiodine uptake in thyroid cells subjected to extrinsic or intrinsic genotoxic stress. - Highlights: • DNA damage inhibits polarized iodide transport in normal thyroid cells. • Down-regulation of NIS expression is mediated by activation of the ATM kinase. • Long-term ATM inhibition also represses NIS-mediated iodide transport. • IGF-1 rescues NIS expression and iodide transport in DNA-damaged cells.

  10. Imaging of human sodium-iodide symporter gene expression mediated by recombinant adenovirus in skeletal muscle of living rats

    International Nuclear Information System (INIS)

    Yang, Hyun Suk; Park, Seong-Wook; Lee, Heuiran; Kim, Sung Jin; Lee, Won Woo; Yang, You-Jung; Moon, Dae Hyuk

    2004-01-01

    We evaluated the feasibility of non-invasive imaging of recombinant adenovirus-mediated human sodium-iodide symporter (hNIS) gene expression by 99m TcO 4 - scintigraphy in skeletal muscle of rats. Replication-defective recombinant adenovirus encoding hNIS gene [Rad-CMV-hNIS 5 x 10 7 , 2 x 10 8 or 1 x 10 9 plaque forming units (pfu)] or β-galactosidase gene (Rad-CMV-LacZ 1 x 10 9 pfu) was injected into the right biceps femoris muscle of rats (n=5-6 for each group). Three days after gene transfer, scintigraphy was performed using a gamma camera 30 min after injection of 99m TcO 4 - (1.85 MBq). An additional two rats injected with 1 x 10 9 pfu of Rad-CMV-hNIS underwent 99m TcO 4 - scintigraphy with sodium perchlorate. After the imaging studies, rats were sacrificed for assessment of the biodistribution of 99m TcO 4 - and measurement of hNIS mRNA expression. In all the rats injected with 1 x 10 9 pfu of Rad-CMV-hNIS, hNIS expression was successfully imaged by 99m TcO 4 - scintigraphy, while rats injected with Rad-CMV-LacZ or lower doses of Rad-CMV-hNIS failed to show uptake. The biodistribution studies indicated that a significantly different amount of 99m TcO 4 - was retained in the liver (p 9 pfu of Rad-CMV-hNIS. The muscular hNIS mRNA level quantified by real-time reverse transcription-polymerase chain reaction was significantly higher in rats injected with 1 x 10 9 pfu of Rad-CMV-hNIS (p 9 pfu of Rad-CMV-hNIS were specifically inhibited by sodium perchlorate. This study illustrated that 99m TcO 4 - scintigraphy can monitor Rad-CMV-hNIS-mediated gene expression in skeletal muscle of rats, non-invasively and quantitatively. (orig.)

  11. Sodium iodide symporter: Its role in nuclear oncology

    International Nuclear Information System (INIS)

    Chung, June-Key

    2004-01-01

    Full text: Thyroid iodide uptake is basic to the clinical applications of radioiodine in diagnosis and therapy. Iodide uptake occurs across the membrane of thyroid follicular cells via an active transporter process mediated by the sodium/iodide symporter (NIS). The recent cloning of the gene encoding NIS enabled better characterization of the molecular mechanisms underlying the iodide transport, thus opening the way to clarify and expand its role in medicine. NIS contains 13 transmembrane segments, and its gene encodes a glycoprotein of 643 amino acids. Decreased NIS expression levels account for the reduced iodide uptake in thyroid carcinomas. We found that thyroid cancer patients with positive immunostaining for NIS responded to I-131 therapy better than did the patients with negative immunostaining. Thus, NIS gene can be used for radionuclide gene therapy. Targeted expression of functional NIS in cancer cells would enable these cells to concentrate iodide from plasma and would, therefore, offer the possibility of radioiodine therapy. We and others have shown that gene transfer of NIS into a variety of cell types confers increased radioiodine uptake up to several hundred-fold that of controls. There is great interest in exploring the possibility of NIS gene transfer to facilitate radioiodine therapy for non-thyroidal human cancers including hepatoma, prostate, breast, colon cancers as well as thyroid cancer. Recently, several approaches such as, targeted gene transfer, thyroid peroxidase gene co-transfection, retinoic acid treatment and Re-188 therapy instead of I-131, have been tried to improve this novel gene therapy. Imaging reporter gene is useful in non-invasively determining the location, duration and magnitude of transgene expression in living animal. Conventionally, HSV-tk and dopaminergic receptor (D2R) genes have been presented as possible imaging reporter genes. We proved that NIS could serve as an alternative imaging reporter gene. NIS has many

  12. Imaging of human sodium-iodide symporter gene expression mediated by recombinant adenovirus in skeletal muscle of living rats

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Hyun Suk; Park, Seong-Wook [Department of Internal Medicine (Cardiology), Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, 138-736, Seoul (Korea); Lee, Heuiran; Kim, Sung Jin [Department of Microbiology, University of Ulsan College of Medicine, Seoul (Korea); Lee, Won Woo [Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam (Korea); Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea); Yang, You-Jung; Moon, Dae Hyuk [Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea)

    2004-09-01

    We evaluated the feasibility of non-invasive imaging of recombinant adenovirus-mediated human sodium-iodide symporter (hNIS) gene expression by {sup 99m}TcO{sub 4}{sup -} scintigraphy in skeletal muscle of rats. Replication-defective recombinant adenovirus encoding hNIS gene [Rad-CMV-hNIS 5 x 10{sup 7}, 2 x 10{sup 8} or 1 x 10{sup 9} plaque forming units (pfu)] or {beta}-galactosidase gene (Rad-CMV-LacZ 1 x 10{sup 9} pfu) was injected into the right biceps femoris muscle of rats (n=5-6 for each group). Three days after gene transfer, scintigraphy was performed using a gamma camera 30 min after injection of {sup 99m}TcO{sub 4}{sup -} (1.85 MBq). An additional two rats injected with 1 x 10{sup 9} pfu of Rad-CMV-hNIS underwent {sup 99m}TcO{sub 4}{sup -} scintigraphy with sodium perchlorate. After the imaging studies, rats were sacrificed for assessment of the biodistribution of {sup 99m}TcO{sub 4}{sup -} and measurement of hNIS mRNA expression. In all the rats injected with 1 x 10{sup 9} pfu of Rad-CMV-hNIS, hNIS expression was successfully imaged by {sup 99m}TcO{sub 4}{sup -} scintigraphy, while rats injected with Rad-CMV-LacZ or lower doses of Rad-CMV-hNIS failed to show uptake. The biodistribution studies indicated that a significantly different amount of {sup 99m}TcO{sub 4}{sup -} was retained in the liver (p<0.001) and the right muscle (p<0.05), with the highest uptake in rats injected with 1 x 10{sup 9} pfu of Rad-CMV-hNIS. The muscular hNIS mRNA level quantified by real-time reverse transcription-polymerase chain reaction was significantly higher in rats injected with 1 x 10{sup 9} pfu of Rad-CMV-hNIS (p<0.05), with a positive correlation with the imaging counts (r=0.810, p<0.05) and the biodistribution (r=0.847, p<0.001). Hot spots in rats injected with 1 x 10{sup 9} pfu of Rad-CMV-hNIS were specifically inhibited by sodium perchlorate. This study illustrated that {sup 99m}TcO{sub 4}{sup -} scintigraphy can monitor Rad-CMV-hNIS-mediated gene expression in

  13. Evaluation of Lentiviral-Mediated Expression of Sodium Iodide Symporter in Anaplastic Thyroid Cancer and the Efficacy of In Vivo Imaging and Therapy

    Directory of Open Access Journals (Sweden)

    Chien-Chih Ke

    2011-01-01

    Full Text Available Anaplastic thyroid carcinoma (ATC is one of the most deadly cancers. With intensive multimodalities of treatment, the survival remains low. ATC is not sensitive to 131I therapy due to loss of sodium iodide symporter (NIS gene expression. We have previously generated a stable human NIS-expressing ATC cell line, ARO, and the ability of iodide accumulation was restored. To make NIS-mediated gene therapy more applicable, this study aimed to establish a lentiviral system for transferring hNIS gene to cells and to evaluate the efficacy of in vitro and in vivo radioiodide accumulation for imaging and therapy. Lentivirus containing hNIS cDNA were produced to transduce ARO cells which do not concentrate iodide. Gene expression, cell function, radioiodide imaging and treatment were evaluated in vitro and in vivo. Results showed that the transduced cells were restored to express hNIS and accumulated higher amount of radioiodide than parental cells. Therapeutic dose of 131I effectively inhibited the tumor growth derived from transduced cells as compared to saline-treated mice. Our results suggest that the lentiviral system efficiently transferred and expressed hNIS gene in ATC cells. The transduced cells showed a promising result of tumor imaging and therapy.

  14. Nonintersecting string model and graphical approach: equivalence with a Potts model

    International Nuclear Information System (INIS)

    Perk, J.H.H.; Wu, F.Y.

    1986-01-01

    Using a graphical method the authors establish the exact equivalence of the partition function of a q-state nonintersecting string (NIS) model on an arbitrary planar, even-valenced lattice with that of a q 2 -state Potts model on a relaxed lattice. The NIS model considered in this paper is one in which the vertex weights are expressible as sums of those of basic vertex types, and the resulting Potts model generally has multispin interactions. For the square and Kagome lattices this leads to the equivalence of a staggered NIS model with Potts models with anisotropic pair interactions, indicating that these NIS models have a first-order transition for q greater than 2. For the triangular lattice the NIS model turns out to be the five-vertex model of Wu and Lin and it relates to a Potts model with two- and three-site interactions. The most general model the authors discuss is an oriented NIS model which contains the six-vertex model and the NIS models of Stroganov and Schultz as special cases

  15. Nosocomial infections among acute leukemia patients in China: An economic burden analysis.

    Science.gov (United States)

    Wu, Xiaohui; Yan, Tianyuan; Liu, Yunhong; Wang, Jingna; Li, Yingxia; Wang, Shuhui

    2016-10-01

    The economic burden associated nosocomial infections (NIs) in patients with acute leukemia (AL) in China was unclear. A prospective study was conducted to quantify the medical cost burden of NIs among AL patients. Nine hundred ninety-four patients diagnosed with AL between January 2011 and December 2013 were included. Relevant necessary information was extracted from the hospital information system and hospital infection surveillance system. The primary outcome was incidence of NIs and the secondary was economic burden results, including extra medical costs and prolonged length of stay (LOS). We estimated the total incremental cost of NIs by comparing all-cause health care costs in patients with versus without infections. Prolonged duration of stay was compared in patients with different infections. Of 994 patients with AL, 277 (27.9%) experienced NIs. NI was associated with a total incremental cost of $3,092 per patient ($5,227 vs $2,135; P economic burden on patients with AL. The study highlights the influence of NIs on LOS and health care costs and appeal to the establishment of prophylactic measures for NIs to reduce the unnecessary waste of medical resources in the long run. Copyright © 2016 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

  16. The effect of tanespimycin (17-AAG) on radioiodine accumulation in sodium iodide symporter expressing cells

    International Nuclear Information System (INIS)

    Yu, Kyoung Hyun; Youn, Hyewon; Song, Myung Geun; Lee, Dong Soo; Chung, June Key

    2012-01-01

    The heat shock protein 90 inhibitor, tanespimycin, is an anticancer agent known to increase iodine accumulation in normal and cancerous thyroid cells. Iodine accumulation is regulated by membrane proteins such as sodium iodide sym porter (NIS) and pendrin (PDS), and thus we attempted to characterize the effects of tanespimycin on those genes. Cells were incubated with tanespimycin in order to evaluate 125 I accumulation and efflux ability. Radioiodine uptake and efflux were measured by a gamma counter and normalized by protein amount. RT PCR were performed to measure the level of gene expression. After tanespimycin treatment, 125 uptake was in creased by ∼2.5 fold in FRTL 5, hNIS ARO. and hNIS MDA MB 231 cells, but no changes were detected in the hNIS HeLa cells. Tanespimycin significantly reduced the radioiodine efflux rate only in the FRTL 5 cell. in the FRTL 5 and hNIS ARO cells, PDS mRNA levels were markedly reduced; the only other observed alteration in the levels of NIS mRNA after tanespimtycin treatment was an observed increase in the h hNIS ARO cells. These results indicate that cellular responses against tanespimycin treatment differed between the normal rat thyroid cells and human cancer cells, and the reduction in the 125I efflux rate by tanespimycin in the normal rat thyroid cells might be attributable to reduced PDS gene expression

  17. Characterization of nanostructured photosensitive (NiS)x(CdS)(1-x) composite thin films grown by successive ionic layer adsorption and reaction (SILAR) route

    International Nuclear Information System (INIS)

    Ubale, A.U.; Bargal, A.N.

    2011-01-01

    Highlights: → Thin films of (NiS) x (CdS) (1-x) with variable composition (x = 1 to 0) were deposited onto glass substrates by the successive ionic layer adsorption and reaction (SILAR) method. → The structural, surface morphological and electrical characterizations of the as deposited and annealed films were studied. → The bandgap and activation energy of annealed (NiS) x (CdS) (1-x) film decrease with improvement in photosensitive nature. -- Abstract: Recently ternary semiconductor nanostructured composite materials have attracted the interest of researchers because of their photovoltaic applications. Thin films of (NiS) x (CdS) (1-x) with variable composition (x = 1-0) had been deposited onto glass substrates by the successive ionic layer adsorption and reaction (SILAR) method. As grown and annealed films were characterised by X-ray diffraction, scanning electron microscopy and EDAX to investigate structural and morphological properties. The (NiS) x (CdS) (1-x) films were polycrystalline in nature having mixed phase of rhombohedral and hexagonal crystal structure due to NiS and CdS respectively. The optical and electrical properties of (NiS) x (CdS) (1-x) thin films were studied to determine compsition dependent bandgap, activation energy and photconductivity. The bandgap and activation energy of annealed (NiS) x (CdS) (1-x) film decrease with improvement in photosensitive nature.

  18. Synthesis and Spectral Studies of Ni(II Dithiocarbamate Complexes and Their Use as Precursors for Nickel Sulphides Nanocrystals

    Directory of Open Access Journals (Sweden)

    Azile Nqombolo

    2016-01-01

    Full Text Available Ni(II dithiocarbamate complexes have been synthesized and characterized by UV-Vis, FTIR, and NMR spectroscopic techniques. Electronic spectra measurements indicate that the complexes are four-coordinate square planar geometry while the FTIR confirmed that the dithiocarbamates act as bidentate chelating ligands. The compounds were used as single source precursors and thermolysed at 220°C to prepare HDA-capped NiS nanocrystals which were characterized by absorption and photoluminescence (PL spectra measurements, powder X-ray diffraction (PXRD, transmission electron microscopy (TEM, scanning electron microscopy (SEM, and energy dispersive spectroscopy (EDS. Absorption spectra studies showed that the synthesized NiS nanoparticles are blue-shifted relative to the bulk material and PL studies showed emission maxima that are red-shifted compared to the absorption band edges. The XRD patterns of the as-prepared NiS nanoparticles revealed cubic crystalline phases. TEM images showed spherical and close-to-spherical nanocrystals with the size in the range 12–38 nm for NiS1, 8–11 nm for NiS2, and 9–16 nm for NiS3. SEM images showed homogeneous surface morphology and EDS confirmed the presence of Ni and S and the formation of NiS nanoparticles.

  19. In vitro radionuclide therapy and in vivo scintigraphic imaging of alpha fetoprotein producing hepatocellular carcinoma by targeted sodium iodide symporter gene expression

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kwang Il; Lee, Yong Jin; Lee, Tae Sup; Song, Inho; Cheon, Gi Jeong; Lim, Sang Moo; Kang, Joo Hyun [Korea Institute of Radiological and Medical and Medical Sciences, Seoul (Korea, Republic of); Chung, June Key [Seoul National Univ. College of Medicine, Seoul (Korea, Republic of)

    2012-03-15

    This study aimed to develop a gene expression targeting method for specific imaging and therapy of alpha fetoprotein (AFP) producing hepatocellular carcinoma (HCC) cells, using an adenovirus vector containing the human sodium/iodide symporter (hNIS) gene driven by an AFP enhancer/promoter. The recombinant adenovirus vector, AdAFPhNIS (containing the hNIS gene driven by human AFP enhancer/promoter) was prepared. After in vitro infection by the adenovirus, hNIS gene expression in AFP producing cells and in AFP nonproducing cells was investigated using {sup 125}I uptake assay and semi quantitative reverse transcription polymerase chain reaction (RT-PCR). The killing effect of {sup 131}I vitro clonogenic assay. In addition, tumor bearing mice were intravenously injected with the adenovirus, and scintigraphic images were obtained. The expression of hNIS was efficiently demonstrated by {sup 125}I uptake assay in AFP producing cells, but not in AFP nonproducing cells. AFP producing HCC targeted gene expression was confirmed at the mRNA level. Furthermore, in vitro clonogenic assay showed that hNIS gene expression induced by AdAFPhNIS infection in AFP producing cells caused more sensitivity to {sup 131}I than that in AFP nonproducing cells. Injected intravenously in HuH-7 tumor xenografts mice by adenovirus, the functional hNIS gene expression was confirmed in tumor by in vivo scintigraphic imaging. An AFP producing HCC was targeted with an adenovirus vector containing the hNIS gene using the AFP enhancer/promoter in vitro and in vivo. These findings demonstrate that AFP producing HCC specific molecular imaging and radionuclide gene therapy are feasible using this recombinant adenovirus vector system.

  20. In vitro radionuclide therapy and in vivo scintigraphic imaging of alpha fetoprotein producing hepatocellular carcinoma by targeted sodium iodide symporter gene expression

    International Nuclear Information System (INIS)

    Kim, Kwang Il; Lee, Yong Jin; Lee, Tae Sup; Song, Inho; Cheon, Gi Jeong; Lim, Sang Moo; Kang, Joo Hyun; Chung, June Key

    2012-01-01

    This study aimed to develop a gene expression targeting method for specific imaging and therapy of alpha fetoprotein (AFP) producing hepatocellular carcinoma (HCC) cells, using an adenovirus vector containing the human sodium/iodide symporter (hNIS) gene driven by an AFP enhancer/promoter. The recombinant adenovirus vector, AdAFPhNIS (containing the hNIS gene driven by human AFP enhancer/promoter) was prepared. After in vitro infection by the adenovirus, hNIS gene expression in AFP producing cells and in AFP nonproducing cells was investigated using 125 I uptake assay and semi quantitative reverse transcription polymerase chain reaction (RT-PCR). The killing effect of 131 I vitro clonogenic assay. In addition, tumor bearing mice were intravenously injected with the adenovirus, and scintigraphic images were obtained. The expression of hNIS was efficiently demonstrated by 125 I uptake assay in AFP producing cells, but not in AFP nonproducing cells. AFP producing HCC targeted gene expression was confirmed at the mRNA level. Furthermore, in vitro clonogenic assay showed that hNIS gene expression induced by AdAFPhNIS infection in AFP producing cells caused more sensitivity to 131 I than that in AFP nonproducing cells. Injected intravenously in HuH-7 tumor xenografts mice by adenovirus, the functional hNIS gene expression was confirmed in tumor by in vivo scintigraphic imaging. An AFP producing HCC was targeted with an adenovirus vector containing the hNIS gene using the AFP enhancer/promoter in vitro and in vivo. These findings demonstrate that AFP producing HCC specific molecular imaging and radionuclide gene therapy are feasible using this recombinant adenovirus vector system

  1. Comparison of expressed human and mouse sodium/iodide sym-porters reveals differences in transport properties and subcellular localization

    Energy Technology Data Exchange (ETDEWEB)

    Dayem, M.; Basquin, C.; Navarro, V.; Carrier, P.; Marsault, R.; Lindenthal, S.; Pourcher, T. [Univ Nice Sophia Antipolis, Sch Med, CEA, DSV, iBEB, SBTN, TIRO, F-06107 Nice (France); Chang, P. [CNRS, UPMC Biol Dev, UMR 7009, F-06230 Villefranche Sur Mer (France); Huc, S.; Darrouzet, E. [CEA Valrho, DSV, iBEB, SBTN, F-30207 Bagnols Sur Ceze (France)

    2008-07-01

    The active transport of iodide from the blood stream into thyroid follicular cells is mediated by the Na{sup +}/I{sup -} sym-porter (NIS). We studied mouse NIS (mNIS) and found that it catalyzes iodide transport into transfected cells more efficiently than human NIS (hNIS). To further characterize this difference,we compared {sup 125}I, uptake in the transiently transfected human embryonic kidney (HEK) 293 cells. We found that the Vmax for mNIS was four times higher than that for hNIS, and that the iodide transport constant (Km) was 2-5-fold lower for hNIS than mNIS. We also performed immuno-cyto-localization studies and observed that the subcellular distribution of the two ortho-logs differed. While the mouse protein was predominantly found at the plasma membrane, its human ortho-log was intracellular in {approx} 40% of the expressing cells. Using cell surface protein-labeling assays, we found that the plasma membrane localization frequency of the mouse protein was only 2-5-fold higher than that of the human protein, and therefore cannot alone account for,x values. We reasoned that the difference in the obtained Vmax the observed difference could also be caused by a higher turnover number for iodide transport in the mouse protein. We then expressed and analyzed chimeric proteins. The data obtained with these constructs suggest that the iodide recognition site could be located in the region extending from the N-terminus to transmembrane domain 8, and that the region between transmembrane domain 5 and the C-terminus could play a role in the subcellular localization of the protein. (authors)

  2. Treatment of medulloblastoma using an oncolytic measles virus encoding the thyroidal sodium iodide symporter shows enhanced efficacy with radioiodine

    International Nuclear Information System (INIS)

    Hutzen, Brian; Pierson, Christopher R; Russell, Stephen J; Galanis, Evanthia; Raffel, Corey; Studebaker, Adam W

    2012-01-01

    Medulloblastoma is the most common malignant brain tumor of childhood. Although the clinical outcome for medulloblastoma patients has improved significantly, children afflicted with the disease frequently suffer from debilitating side effects related to the aggressive nature of currently available therapy. Alternative means for treating medulloblastoma are desperately needed. We have previously shown that oncolytic measles virus (MV) can selectively target and destroy medulloblastoma tumor cells in localized and disseminated models of the disease. MV-NIS, an oncolytic measles virus that encodes the human thyroidal sodium iodide symporter (NIS), has the potential to deliver targeted radiotherapy to the tumor site and promote a localized bystander effect above and beyond that achieved by MV alone. We evaluated the efficacy of MV-NIS against medulloblastoma cells in vitro and examined their ability to incorporate radioiodine at various timepoints, finding peak uptake at 48 hours post infection. The effects of MV-NIS were also evaluated in mouse xenograft models of localized and disseminated medulloblastoma. Athymic nude mice were injected with D283med-Luc medulloblastoma cells in the caudate putamen (localized disease) or right lateral ventricle (disseminated disease) and subsequently treated with MV-NIS. Subsets of these mice were given a dose of 131 I at 24, 48 or 72 hours later. MV-NIS treatment, both by itself and in combination with 131 I, elicited tumor stabilization and regression in the treated mice and significantly extended their survival times. Mice given 131 I were found to concentrate radioiodine at the site of their tumor implantations. In addition, mice with localized tumors that were given 131 I either 24 or 48 hours after MV-NIS treatment exhibited a significant survival advantage over mice given MV-NIS alone. These data suggest MV-NIS plus radioiodine may be a potentially useful therapy for the treatment of medulloblastoma

  3. Assessment of the Na/I symporter as a reporter gene to visualize oncolytic adenovirus propagation in peritoneal tumours

    International Nuclear Information System (INIS)

    Merron, Andrew; McNeish, Iain A.; Baril, Patrick; Tran, Lucile; Vassaux, Georges; Martin-Duque, Pilar; Vieja, Antonio de la; Briat, Arnaud; Harrington, Kevin J.

    2010-01-01

    In vivo imaging of the spread of oncolytic viruses using the Na/I symporter (NIS) has been proposed. Here, we assessed whether the presence of NIS in the viral genome affects the therapeutic efficacy of the oncolytic adenovirus dl922-947 following intraperitoneal administration, in a mouse model of peritoneal ovarian carcinoma. We generated AdAM7, a dl922-947 oncolytic adenovirus encoding the NIS coding sequence. Iodide uptake, NIS expression, infectivity and cell-killing activity of AdAM7, as well as that of relevant controls, were determined in vitro. In vivo, the propagation of this virus in the peritoneal cavity of tumour-bearing mice was determined using SPECT/CT imaging and its therapeutic efficacy was evaluated. In vitro infection of ovarian carcinoma IGROV-1 cells with ADAM7 led to functional expression of NIS. However, the insertion of NIS into the viral genome resulted in a loss of efficacy of the virus in terms of replication and cytotoxicity. In vivo, on SPECT/CT imaging AdAM7 was only detectable in the peritoneal cavity of animals bearing peritoneal ovarian tumours for up to 5 days after intraperitoneal administration. Therapeutic experiments in vivo demonstrated that AdAM7 is as potent as its NIS-negative counterpart. This study demonstrated that despite the detrimental effect observed in vitro, insertion of the reporter gene NIS in an oncolytic adenovirus did not affect its therapeutic efficacy in vivo. We conclude that NIS is a highly relevant reporter gene to monitor the fate of oncolytic adenovectors in live subjects. (orig.)

  4. Assessment of the Na/I symporter as a reporter gene to visualize oncolytic adenovirus propagation in peritoneal tumours

    Energy Technology Data Exchange (ETDEWEB)

    Merron, Andrew; McNeish, Iain A. [Queen Mary' s School of Medicine and Dentistry, Centre for Molecular Oncology, Institute of Cancer, London (United Kingdom); Baril, Patrick; Tran, Lucile; Vassaux, Georges [CHU Hotel Dieu, INSERM, Nantes (France); CHU de Nantes, Institut des Maladies de l' Appareil Digestif, Nantes (France); Martin-Duque, Pilar [Instituto Aragones de Ciencias de la Salud, Zaragoza (Spain); Vieja, Antonio de la [Instituto de Investigaciones Biomedicas, Madrid (Spain); Briat, Arnaud [INSERM U877, Grenoble (France); Harrington, Kevin J. [Chester Beatty Laboratories, Institute of Cancer Research, London (United Kingdom)

    2010-07-15

    In vivo imaging of the spread of oncolytic viruses using the Na/I symporter (NIS) has been proposed. Here, we assessed whether the presence of NIS in the viral genome affects the therapeutic efficacy of the oncolytic adenovirus dl922-947 following intraperitoneal administration, in a mouse model of peritoneal ovarian carcinoma. We generated AdAM7, a dl922-947 oncolytic adenovirus encoding the NIS coding sequence. Iodide uptake, NIS expression, infectivity and cell-killing activity of AdAM7, as well as that of relevant controls, were determined in vitro. In vivo, the propagation of this virus in the peritoneal cavity of tumour-bearing mice was determined using SPECT/CT imaging and its therapeutic efficacy was evaluated. In vitro infection of ovarian carcinoma IGROV-1 cells with ADAM7 led to functional expression of NIS. However, the insertion of NIS into the viral genome resulted in a loss of efficacy of the virus in terms of replication and cytotoxicity. In vivo, on SPECT/CT imaging AdAM7 was only detectable in the peritoneal cavity of animals bearing peritoneal ovarian tumours for up to 5 days after intraperitoneal administration. Therapeutic experiments in vivo demonstrated that AdAM7 is as potent as its NIS-negative counterpart. This study demonstrated that despite the detrimental effect observed in vitro, insertion of the reporter gene NIS in an oncolytic adenovirus did not affect its therapeutic efficacy in vivo. We conclude that NIS is a highly relevant reporter gene to monitor the fate of oncolytic adenovectors in live subjects. (orig.)

  5. Comparison of expressed human and mouse sodium/iodide sym-porters reveals differences in transport properties and subcellular localization

    International Nuclear Information System (INIS)

    Dayem, M.; Basquin, C.; Navarro, V.; Carrier, P.; Marsault, R.; Lindenthal, S.; Pourcher, T.; Chang, P.; Huc, S.; Darrouzet, E.

    2008-01-01

    The active transport of iodide from the blood stream into thyroid follicular cells is mediated by the Na + /I - sym-porter (NIS). We studied mouse NIS (mNIS) and found that it catalyzes iodide transport into transfected cells more efficiently than human NIS (hNIS). To further characterize this difference,we compared 125 I, uptake in the transiently transfected human embryonic kidney (HEK) 293 cells. We found that the Vmax for mNIS was four times higher than that for hNIS, and that the iodide transport constant (Km) was 2-5-fold lower for hNIS than mNIS. We also performed immuno-cyto-localization studies and observed that the subcellular distribution of the two ortho-logs differed. While the mouse protein was predominantly found at the plasma membrane, its human ortho-log was intracellular in ∼ 40% of the expressing cells. Using cell surface protein-labeling assays, we found that the plasma membrane localization frequency of the mouse protein was only 2-5-fold higher than that of the human protein, and therefore cannot alone account for,x values. We reasoned that the difference in the obtained Vmax the observed difference could also be caused by a higher turnover number for iodide transport in the mouse protein. We then expressed and analyzed chimeric proteins. The data obtained with these constructs suggest that the iodide recognition site could be located in the region extending from the N-terminus to transmembrane domain 8, and that the region between transmembrane domain 5 and the C-terminus could play a role in the subcellular localization of the protein. (authors)

  6. Treatment of medulloblastoma using an oncolytic measles virus encoding the thyroidal sodium iodide symporter shows enhanced efficacy with radioiodine

    Directory of Open Access Journals (Sweden)

    Hutzen Brian

    2012-11-01

    Full Text Available Abstract Background Medulloblastoma is the most common malignant brain tumor of childhood. Although the clinical outcome for medulloblastoma patients has improved significantly, children afflicted with the disease frequently suffer from debilitating side effects related to the aggressive nature of currently available therapy. Alternative means for treating medulloblastoma are desperately needed. We have previously shown that oncolytic measles virus (MV can selectively target and destroy medulloblastoma tumor cells in localized and disseminated models of the disease. MV-NIS, an oncolytic measles virus that encodes the human thyroidal sodium iodide symporter (NIS, has the potential to deliver targeted radiotherapy to the tumor site and promote a localized bystander effect above and beyond that achieved by MV alone. Methods We evaluated the efficacy of MV-NIS against medulloblastoma cells in vitro and examined their ability to incorporate radioiodine at various timepoints, finding peak uptake at 48 hours post infection. The effects of MV-NIS were also evaluated in mouse xenograft models of localized and disseminated medulloblastoma. Athymic nude mice were injected with D283med-Luc medulloblastoma cells in the caudate putamen (localized disease or right lateral ventricle (disseminated disease and subsequently treated with MV-NIS. Subsets of these mice were given a dose of 131I at 24, 48 or 72 hours later. Results MV-NIS treatment, both by itself and in combination with 131I, elicited tumor stabilization and regression in the treated mice and significantly extended their survival times. Mice given 131I were found to concentrate radioiodine at the site of their tumor implantations. In addition, mice with localized tumors that were given 131I either 24 or 48 hours after MV-NIS treatment exhibited a significant survival advantage over mice given MV-NIS alone. Conclusions These data suggest MV-NIS plus radioiodine may be a potentially useful therapy for

  7. Evaluating nonindigenous species management in a Bayesian networks derived relative risk framework for Padilla Bay, WA, USA.

    Science.gov (United States)

    Herring, Carlie E; Stinson, Jonah; Landis, Wayne G

    2015-10-01

    Many coastal regions are encountering issues with the spread of nonindigenous species (NIS). In this study, we conducted a regional risk assessment using a Bayesian network relative risk model (BN-RRM) to analyze multiple vectors of NIS introductions to Padilla Bay, Washington, a National Estuarine Research Reserve. We had 3 objectives in this study. The 1st objective was to determine whether the BN-RRM could be used to calculate risk from NIS introductions for Padilla Bay. Our 2nd objective was to determine which regions and endpoints were at greatest risk from NIS introductions. Our 3rd objective was to incorporate a management option into the model and predict endpoint risk if it were to be implemented. Eradication can occur at different stages of NIS invasions, such as the elimination of these species before being introduced to the habitat or removal of the species after settlement. We incorporated the ballast water treatment management scenario into the model, observed the risk to the endpoints, and compared this risk with the initial risk estimates. The model results indicated that the southern portion of the bay was at greatest risk because of NIS. Changes in community composition, Dungeness crab, and eelgrass were the endpoints most at risk from NIS introductions. The currents node, which controls the exposure of NIS to the bay from the surrounding marine environment, was the parameter that had the greatest influence on risk. The ballast water management scenario displayed an approximate 1% reduction in risk in this Padilla Bay case study. The models we developed provide an adaptable template for decision makers interested in managing NIS in other coastal regions and large bodies of water. © 2015 SETAC.

  8. Functional magnetic resonance imaging of the kidneys; Funktionelle Magnetresonanztomographie der Nieren

    Energy Technology Data Exchange (ETDEWEB)

    Lanzman, R.S.; Wittsack, H.J. [Universitaetsklinik Duesseldorf, Institut fuer Diagnostische und Interventionelle Radiologie, Duesseldorf (Germany); Notohamiprodjo, M. [Universitaetsklinik Tuebingen, Abteilung fuer Diagnostische und Interventionelle Radiologie, Tuebingen (Germany)

    2015-12-15

    Interest in functional renal magnetic resonance imaging (MRI) has significantly increased in recent years. This review article provides an overview of the most important functional imaging techniques and their potential clinical applications for assessment of native and transplanted kidneys, with special emphasis on the clarification of renal tumors. (orig.) [German] Die funktionelle MRT der Nieren hat in den letzten Jahren zunehmend an Bedeutung gewonnen. In diesem Uebersichtsartikel werden die wichtigsten funktionellen Untersuchungstechniken vorgestellt und deren potenzielle klinische Bedeutung zur Evaluation von Nieren und Transplantatnieren hervorgehoben, wobei ein besonderes Augenmerk auf die Abklaerung von Nierentumoren gelegt wird. (orig.)

  9. Bewertung von Fahrzeuggeräuschen

    Science.gov (United States)

    Genuit, Klaus; Schulte-Fortkamp, Brigitte; Fiebig, André; Haverkamp, Michael

    Bei der Wahrnehmung und Beurteilung eines Automobils sind unzählige Merkmale und Eigenschaften von Bedeutung. Dabei können Merkmale objektiv-technisch beschrieben werden, wie Angaben zur Motorisierung, Höchstgeschwindigkeit, Drehmoment, zulässige Zuladung, Verbrauch usw. Daneben sind weitere Eigenschaften von Bedeutung, die sich einer einfachen objektiv-technischen Beschreibung entziehen. Hier sind Begriffe zu nennen, wie Sicherheit, allgemeine Qualitätsanmutung, Design, Ergonomie, Komfort, Haptik, Fahrdynamik, Zuverlässigkeit, die deutlich schwieriger objektiv erfassbar und beschreibbar sind (Abb. 4.1).

  10. Fachsprachensemantik. Grundlagen ihrer (kognitionslinguistischen) Beschreibung

    DEFF Research Database (Denmark)

    Engberg, Jan

    2002-01-01

    Vertikalitätsannahme von Wichter (z.B. Wichter 1994) und die Annahme der Gradualität von Fachlichkeit von Kalverkämper (1991). Diese Grundlagen bedeuten, dass davon ausgegangen wird, dass die Bedeutung von Fachwörtern, die bei Fachleuten zugeschrieben werden, sich in vielen Fällen lediglich graduell von Bedeutungen...... unterscheiden, die bei Nicht-Fachleuten existieren. Gleichzeitig bedeuten die Annahmen, dass von einer graduierten Geltung unterschiedlicher Bedeutungsregeln auszugehen ist, die bei der Konstruktion von Bedeutung in aktueller Kommunikation eingesetzt werden. Objekt des Modells sind damit individuelle...

  11. Sprechkompetenz im DaF-Unterricht an Slowenischen Gymnasien: von der Theorie zur Praxis

    Directory of Open Access Journals (Sweden)

    Andreja Retelj

    2016-12-01

    Full Text Available Es liegt auf der Hand, dass Fremdsprachenkenntnisse aufgrund der wachsenden Globalisierung stets an Bedeutung gewinnen. Über eine hochentwickelte Fremdsprachenkompetenz zu verfügen, ist in der heutigen Gesellschaft fast zur Selbstverständlichkeit geworden. Durch die wachsenden wirtschaftlichen Kontakte gewinnt vor allem die mündliche Kommunikation immer mehr an Bedeutung und die Erwartungen an Fremdsprachenlernende, in verschiedenen Sprachsituationen mündlich schnell und angemessen kommunizieren zu können, nehmen aus diesem Grund ständig zu.

  12. Sterol regulatory element-binding proteins are regulators of the sodium/iodide symporter in mammary epithelial cells.

    Science.gov (United States)

    Wen, G; Pachner, L I; Gessner, D K; Eder, K; Ringseis, R

    2016-11-01

    The sodium/iodide symporter (NIS), which is essential for iodide concentration in the thyroid, is reported to be transcriptionally regulated by sterol regulatory element-binding proteins (SREBP) in rat FRTL-5 thyrocytes. The SREBP are strongly activated after parturition and throughout lactation in the mammary gland of cattle and are important for mammary epithelial cell synthesis of milk lipids. In this study, we tested the hypothesis that the NIS gene is regulated also by SREBP in mammary epithelial cells, in which NIS is functionally expressed during lactation. Regulation of NIS expression and iodide uptake was investigated by means of inhibition, silencing, and overexpression of SREBP and by reporter gene and DNA-binding assays. As a mammary epithelial cell model, the human MCF-7 cell line, a breast adenocarcinoma cell line, which shows inducible expression of NIS by all-trans retinoic acid (ATRA), and unlike bovine mammary epithelial cells, is widely used to investigate the regulation of mammary gland NIS and NIS-specific iodide uptake, was used. Inhibition of SREBP maturation by treatment with 25-hydroxycholesterol (5 µM) for 48h reduced ATRA (1 µM)-induced mRNA concentration of NIS and iodide uptake in MCF-7 cells by approximately 20%. Knockdown of SREBP-1c and SREBP-2 by RNA interference decreased the mRNA and protein concentration of NIS by 30 to 50% 48h after initiating knockdown, whereas overexpression of nuclear SREBP (nSREBP)-1c and nSREBP-2 increased the expression of NIS in MCF-7 cells by 45 to 60%, respectively, 48h after initiating overexpression. Reporter gene experiments with varying length of NIS promoter reporter constructs revealed that the NIS 5'-flanking region is activated by nSREBP-1c and nSREBP-2 approximately 1.5- and 4.5-fold, respectively, and activation involves a SREBP-binding motif (SRE) at -38 relative to the transcription start site of the NIS gene. Gel shift assays using oligonucleotides spanning either the wild-type or the

  13. 89 - 92 Abdullahi

    African Journals Online (AJOL)

    DR. AMINU

    2012-12-02

    Dec 2, 2012 ... 1Department of Applied Biology and 2Department of Plant Science, Bayero ... odour and turbidity, while low pH causes corrosion of .... STDS = Standards, NIS = Nigerian Industrial Standard, WHO = World Health Organization.

  14. Uued tulijad tutvustavad end diplomilavastustega / Ülle Jantson

    Index Scriptorium Estoniae

    Jantson, Ülle

    2007-01-01

    Janusz Glowacki "Fortinbras jõi end täis" Viljandi Kultuuriakadeemia teatrikunsti eriala 6. lennu esituses (lavastaja Kalju Komissarov ja Sven Heiberg) ja Anton Tshehhovi "Kolm õde" Endla küünis (lavastaja-koreograaf Oleg Titov)

  15. NNSA Staff Member Receives NNSA Recognition

    Energy Technology Data Exchange (ETDEWEB)

    Specht, Elaine S.

    2013-04-01

    This article is intended for publication in the NNSA Nonproliferation and International Security (NIS) Highlights, a quarterly newsletter available in print and e-form. It will be published on the NNSA website and is intended for public release.

  16. DIPHTHERIA SEROPREVALENCE IN CHILDREN LIVING IN THE ...

    African Journals Online (AJOL)

    hi-tech

    2003-12-01

    Dec 1, 2003 ... At that time, the elimination of ... Independent States (NIS) of former Soviet Union draw attention to our lack ... consent was obtained from all parents of the children and a pediatrician ..... age-wise changes in immunity. Scand.

  17. Interaction of measles virus vectors with Auger electron emitting radioisotopes

    International Nuclear Information System (INIS)

    Dingli, David; Peng, K.-W.; Harvey, Mary E.; Vongpunsawad, Sompong; Bergert, Elizabeth R.; Kyle, Robert A.; Cattaneo, Roberto; Morris, John C.; Russell, Stephen J.

    2005-01-01

    A recombinant measles virus (MV) expressing the sodium iodide symporter (NIS) is being considered for therapy of advanced multiple myeloma. Auger electrons selectively damage cells in which the isotope decays. We hypothesized that the Auger electron emitting isotope 125 I can be used to control viral proliferation. MV was engineered to express both carcinoembryonic antigen and NIS (MV-NICE). Cells were infected with MV-NICE and exposed to 125 I with appropriate controls. MV-NICE replication in vitro is inhibited by the selective uptake of 125 I by cells expressing NIS. Auger electron damage is partly mediated by free radicals and abrogated by glutathione. In myeloma xenografts, control of MV-NICE with 125 I was not possible under the conditions of the experiment. MV-NICE does not replicate faster in the presence of radiation. Auger electron emitting isotopes effectively stop propagation of MV vectors expressing NIS in vitro. Additional work is necessary to translate these observations in vivo

  18. 2012 National Immunization Survey Data

    Science.gov (United States)

    ... Tweet Share Compartir This website is archived for historical purposes and is no longer being maintained or ... 12, 2013: Content on this page kept for historical reasons. National Immunization Survey (NIS) – Children (19-35 ...

  19. Modernisation strategy for National Irrigation Systems in the Philippines

    NARCIS (Netherlands)

    Delos Reyes, Mona Liza Fortunado

    2017-01-01

    The performance of publicly funded canal irrigation systems or more commonly called national irrigation systems (NIS) in the Philippines remained below expectations despite considerable system rehabilitation and improvement efforts. The continued suboptimal performances were attributed to

  20. Nutrition, Physical Activity, and Obesity - National Immunization Survey (Breastfeeding)

    Data.gov (United States)

    U.S. Department of Health & Human Services — This dataset includes breastfeeding data from the National Immunization Survey (NIS). This data is used for DNPAO's Data, Trends, and Maps database, which provides...

  1. Nutrition impact symptoms, handgrip strength and nutritional risk in hospitalized patients with gastroenterological and liver diseases

    DEFF Research Database (Denmark)

    Wilkens Knudsen, Anne; Naver, Astrid; Bisgaard, Karen

    2015-01-01

    OBJECTIVE: Malnutrition is common among patients with diseases of the liver and gastrointestinal tract. Nutritional intake may be negatively affected by nutrition impact symptoms (NIS). Therefore, the aims were to assess: 1) the prevalence of NIS in this group of patients and 2) the relationship...... between NIS and nutritional status as well as nutritional risk. MATERIAL AND METHODS: We performed a cross-sectional study among patients with liver disease, inflammatory bowel disease, cancer or pancreatitis. Nutritional risk was assessed by the NRS-2002. Nutritional status was assessed by body mass......). The prevalence of low HGS was 38%, and the prevalence of those at nutritional risk was 58%. The number of NIS reported by 50% of the patients were 4 or more in the ESQ and 5 or more in the DRAQ. Patients who were both at nutritional risk and had a low HGS more frequently reported difficulties swallowing, poor...

  2. The U.S. Intelligence Community's Five Year Strategic Human Capital Plan

    National Research Council Canada - National Science Library

    2006-01-01

    .... The National Intelligence Strategy (NIS) requires a 5-year human capital strategy that will build an agile, "all source" workforce by projecting and planning for mission critical human resource requirements...

  3. SILAR deposition of nickel sulfide counter electrode for application in quantum dot sensitized solar cell

    Science.gov (United States)

    Singh, Navjot; Siwatch, Poonam; Arora, Anmol; Sharma, Jadab; Tripathi, S. K.

    2018-05-01

    Quantum Dot Sensitized Solar Cells are a likely replacement for Silicon-based solar cells. Counter electrodes are a fundamental aspect of QDSSC's performance. NiS being a less expensive material is a decent choice for the purpose. In this paper, we have discussed the synthesis of NiS by Successive Ionic Layer Adsorption Reaction. Optical, Crystallographic and Electrical studies have been presented. Electrical studies of the device with NiS counter electrode is compared with characteristics of the device with CNTs as the counter electrode. SILAR method is easy and less time to consume than chemical bath deposition or any other method. Results show the success of NiS synthesized by SILAR method as the counter electrode.

  4. V zamke otkrõlas võstavka fotografi prirodõ Finljandii

    Index Scriptorium Estoniae

    2008-01-01

    Soome loodusfotode näitus "Frozen Horizon" Narva linnuses. Oma töid näitavad Oulu läänis tegutsevad loodusfotograafid Kalervo Ojutkangas, Jorma Luhta, Hannu Hautala, Tauno Kohonen ja Hannu Huttu. Fotograafidest

  5. Sodium Iodide Symporter Gene Transfer for Imaging and Ablation of Prostate Cancer

    National Research Council Canada - National Science Library

    Jhiang, Sissy M

    2005-01-01

    .... The specific aims of this project are to: (1) confirm metastatic progression to distant lymph nodes and lungs following subcutaneous inoculation of rats with MATLyLu prostatic adenocarcinoma cells expressing hNIS; (2...

  6. sugar cane juice as a retarding admixture in concrete production

    African Journals Online (AJOL)

    PROF. BARTH EKWEME

    features of this conglomerate material depend on the properties of ... when the temperature of cement mortar with a water/cement ... following mechanisms. 1) Adsorption ... poisoning their growth, which is essential .... Copper (mg/kg). NIS 235.

  7. A study on national innovation system for the improvement of nuclear R and D performance

    Energy Technology Data Exchange (ETDEWEB)

    Yun, S. W.; Oh, K. B.; Kim, H. J.; Cheong, H. S.; Cheong, I.; Lee, J. H.; Won, B. C.; Cheong, C. E.; Lee, K. H.; Choi, H. M

    2006-01-15

    Review basic concept and analytical method concerned with technological innovation and NIS : concept and defition of technological innovation and NIS, background and evolution of the NIS theory, basic elements of NIS and their relationship. Identification on scientific-technological characteristics of the nuclear R and D and technological innovation : special aspect of the nuclear R and D and technological innovation, difficulty(or complexity) of the nuclear R and D and technological, innovation. Defining organizational-institutional elements of nuclear R and D and innovation allowing for nuclear scientific-technological peculiarity. Developing the model of national nuclear innovation system for analysis of the national R and D performance. Developing the analytical model including performance measure and procedure for national nuclear innovation system led mainly by national Rand D in Korea. Discussion about the national innovation system with other OECD/NEA member countries.

  8. A study on national innovation system for the improvement of nuclear R and D performance

    International Nuclear Information System (INIS)

    Yun, S. W.; Oh, K. B.; Kim, H. J.; Cheong, H. S.; Cheong, I.; Lee, J. H.; Won, B. C.; Cheong, C. E.; Lee, K. H.; Choi, H. M.

    2006-01-01

    Review basic concept and analytical method concerned with technological innovation and NIS : concept and defition of technological innovation and NIS, background and evolution of the NIS theory, basic elements of NIS and their relationship. Identification on scientific-technological characteristics of the nuclear R and D and technological innovation : special aspect of the nuclear R and D and technological innovation, difficulty(or complexity) of the nuclear R and D and technological, innovation. Defining organizational-institutional elements of nuclear R and D and innovation allowing for nuclear scientific-technological peculiarity. Developing the model of national nuclear innovation system for analysis of the national R and D performance. Developing the analytical model including performance measure and procedure for national nuclear innovation system led mainly by national Rand D in Korea. Discussion about the national innovation system with other OECD/NEA member countries

  9. Healthcare Cost and Utilization Project (HCUP) - National Inpatient Sample

    Data.gov (United States)

    U.S. Department of Health & Human Services — 2001 forward. The National (Nationwide) Inpatient Sample (NIS) is part of a family of databases and software tools developed for the Healthcare Cost and Utilization...

  10. Helsingi Teatriakadeemia tantsukompanii TADaC Eestis 2009 / Evelin Lagle

    Index Scriptorium Estoniae

    Lagle, Evelin, 1986-

    2009-01-01

    Tantsulavastustest: Harri Kuorelahti "Rough Plan" ja Ari Tehnula "Distances - Practices of Kinetic Empathy" 3. mail Pärnu Endla Küünis, 5. mail Tallinnas Kumu auditooriumis ning 7. mail Tartu Sadamateatris

  11. African Journal of Biotechnology - Vol 13, No 53 (2014)

    African Journals Online (AJOL)

    Cloning of nis gene and Nisin purification from Lactococcus lactis subsp. lactis Fc2 · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. DE El-hadedy, EW El-gammal ...

  12. Assessment of Nonindigenous Species on Coral Reefs in the Hawaiian Islands, with Emphasis on Introduced Invertebrates, November 2, 2002 - November 5, 2003 (NODC Accession 0001419)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Coral reefs on the islands of Kauai, Molokai, Maui, Hawaii and Oahu were surveyed for the presence and impact of marine nonindigenous and cryptogenic species (NIS)...

  13. Radiostatine and radioiodine uptake characterization in sodium iodine symporter-expressing cell lines

    International Nuclear Information System (INIS)

    Petrich, T.; Helmeke, H.J.; Meyer, G.J.; Knapp, W.H.; Poetter, E.

    2002-01-01

    Full text: The sodium iodide symporter (NIS) has been recognized as an attractive target for cancer gene therapy. Here we investigated NIS-mediated transport of the high LET α-emitter astatine, 211 At, in comparison to radioiodine. A constitutive expression vector harbouring the human NIS cDNA was used in combination with reporter gene vectors for transient transfection of 13 different human cancer cell lines. Radioiodine uptake was measured as well as transfection efficiencies. Six stable NIS-expressing cell lines (3 derived from thyroid carcinomas, 2 colon carcinoma, 1 glioblastoma) were generated by antibiotic selection. NIS expression was monitored by immunohistochemistry and RT-PCR. Subsequently the radioastatine and radioiodine uptake characteristics of genetically modified cells were studied in comparison to the respective control cells. After xenotransplantation in nude mice in vivo tumor imaging by scintigraphy and biodistribution studies following organ removal were performed. Transient transfection of NIS cDNA led to high specific sodium perchlorate-sensitive radioiodine uptake in NIS-expressing cells that roughly correlates to transfection efficiencies. Similarly, stable NIS-expressing cell lines were able to concentrate high levels of radioiodine and in addition showed comparable transport capacity for radioastatine. Accumulation of 211 At was inhibited by sodium perchlorate like iodide uptake and displayed dependency an extracellular Na + - and I - -ions as well. Compared to wash-out experiments in cell culture the effective half life of radioiodine and radioastatine in vivo was significantly prolonged. Preliminary dose calculations by MIRD concepts indicated higher tumor radiation doses for 211 At compared to 131 I. Tumor cells of different origins transfected with the NIS-expression vector specifically and significantly take-up radioiodine and radioastatine in vitro and in vivo. The data provide direct evidence that the NIS efficiently transports

  14. Towards a National Innovation System in México Based on Knowledge

    OpenAIRE

    Helios Feria, Victor; Hidalgo Nuchera, Antonio

    2008-01-01

    In the last years, the research in diverse disciplines has increased the importance of innovation studies at the national level. In this sense, this paper proposes the development of National Innovation Systems (NIS) and its application to the economy in Mexico. Considering the characteristics and limitations of the study region, the mentioned proposal of NIS it is necessary to integrate the study of Knowledge-Based Economies (KBE) approach to study of the different approaches developed about...

  15. Comparison of Modeling Grassland Degradation with and without Considering Localized Spatial Associations in Vegetation Changing Patterns

    Directory of Open Access Journals (Sweden)

    Yuwei Wang

    2018-01-01

    Full Text Available Grassland ecosystems worldwide are confronted with degradation. It is of great importance to understand long-term trajectory patterns of grassland vegetation by advanced analytical models. This study proposes a new approach called a binary logistic regression model with neighborhood interactions, or BLR-NIs, which is based on binary logistic regression (BLR, but fully considers the spatio-temporally localized spatial associations or characterization of neighborhood interactions (NIs in the patterns of grassland vegetation. The BLR-NIs model was applied to a modeled vegetation degradation of grasslands in the Xilin river basin, Inner Mongolia, China. Residual trend analysis on the normalized difference vegetation index (RESTREND-NDVI, which excluded the climatic impact on vegetation dynamics, was adopted as a preprocessing step to derive three human-induced trajectory patterns (vegetation degradation, vegetation recovery, and no significant change in vegetation during two consecutive periods, T1 (2000–2008 and T2 (2007–2015. Human activities, including livestock grazing intensity and transportation accessibility measured by road network density, were included as explanatory variables for vegetation degradation, which was defined for locations if vegetation recovery or no significant change in vegetation in T1 and vegetation degradation in T2 were observed. Our work compared the results of BLR-NIs and the traditional BLR model that did not consider NIs. The study showed that: (1 both grazing intensity and road density had a positive correlation to vegetation degradation based on the traditional BLR model; (2 only road density was found to positively correlate to vegetation degradation by the BLR-NIs model; NIs appeared to be critical factors to predict vegetation degradation; and (3 including NIs in the BLR model improved the model performance substantially. The study provided evidence for the importance of including localized spatial

  16. National Variation in Urethroplasty Cost and Predictors of Extreme Cost: A Cost Analysis with Policy Implications

    OpenAIRE

    Harris, Catherine R.; Osterberg, E. Charles; Sanford, Thomas; Alwaal, Amjad; Gaither, Thomas W.; McAninch, Jack W.; McCulloch, Charles E.; Breyer, Benjamin N.

    2016-01-01

    To determine which factors are associated with higher costs of urethroplasty procedure and whether these factors have been increasing over time. Identification of determinants of extreme costs may help reduce cost while maintaining quality.We conducted a retrospective analysis using the 2001-2010 Healthcare Cost and Utilization Project-Nationwide Inpatient Sample (HCUP-NIS). The HCUP-NIS captures hospital charges which we converted to cost using the HCUP cost-to-charge ratio. Log cost linear ...

  17. Electronic structure of some 3D transition-metal pyrites

    NARCIS (Netherlands)

    Folkerts, W.; Sawatzky, G.A.; Haas, C.; Groot, R.A. de; Hillebrecht, F.U.

    1987-01-01

    Bremsstrahlung Isochromat spectra of FeS2, NiS2, NiS1.2Se0.8 and NiSe2 are reported. These are the first direct experimental evidence for a sharp antibonding p-like state above the Fermi level. A comparison is made with experimental results in the literature. For FeS2, band-structure calculations

  18. Side Effects of Nitrification Inhibitors on Non Target Microbial Processes in Soils

    OpenAIRE

    Johannes Carl Gottlieb Ottow; Gero Benckiser; Ferisman Tindaon

    2011-01-01

    Agricultural chemicals have been used extensively in modern agriculture and toxicological studies suggest a great potential for inducing undesirable effects on non target organisms. A model experiment was conducted in order to determine side effects of three nitrification inhibitors (NIs, 3,4dimethylpyrazolephosphate = DMPP, 4-Chlormethylpyrazole phosphate = ClMPP and dicyandiamide = DCD) on non target microbial processes in soils. Side effects and dose response curve of three NIs were quanti...

  19. Comparing differential tolerance of native and non-indigenous marine species to metal pollution using novel assay techniques

    International Nuclear Information System (INIS)

    Piola, Richard F.; Johnston, Emma L.

    2009-01-01

    Recent research suggests anthropogenic disturbance may disproportionately advantage non-indigenous species (NIS), aiding their establishment within impacted environments. This study used novel laboratory- and field-based toxicity testing to determine whether non-indigenous and native bryozoans (common within marine epibenthic communities worldwide) displayed differential tolerance to the common marine pollutant copper (Cu). In laboratory assays on adult colonies, NIS showed remarkable tolerance to Cu, with strong post-exposure recovery and growth. In contrast, native species displayed negative growth and reduced feeding efficiency across most exposure levels. Field transplant experiments supported laboratory findings, with NIS growing faster under Cu conditions. In field-based larval assays, NIS showed strong recruitment and growth in the presence of Cu relative to the native species. We suggest that strong selective pressures exerted by the toxic antifouling paints used on transport vectors (vessels), combined with metal contamination in estuarine environments, may result in metal tolerant NIS advantaged by anthropogenically modified selection regimes. - Greater tolerance to pollutants in marine NIS may increase the risk of invasion in port and harbours worldwide by providing a competitive advantage over native taxa.

  20. Marine bioinvasions: Differences in tropical copepod communities between inside and outside a port

    Science.gov (United States)

    Soares, Marcelo de Oliveira; Campos, Carolina Coelho; Santos, Nívia Maria Oliveira; Barroso, Hortência de Sousa; Mota, Erika Maria Targino; Menezes, Maria Ozilea Bezerra de; Rossi, Sergio; Garcia, Tatiane Martins

    2018-04-01

    The difficulty of detecting non-indigenous species (NIS) in marine environments is an "invisible problem" in areas where plankton monitoring does not occur. In this study, we investigated the dominance of the NIS Temora turbinata and copepod community structure in two tropical marine habitats: inside an offshore port, which had turbid and calm waters, and outside the port, which was more hydrodynamic. Our study area was on the northeast coast of Brazil. We found 17 taxa of Copepoda, which were dominated by T. turbinata and the congener, T. stylifera. The high average density of the NIS (21.03 ind./m3) was in stark contrast with that of the native copepods (0.01-3.27 ind./m3). The NIS density was negatively correlated with the species richness and evenness of the native community, was significantly higher inside the port than outside, and was positively correlated with phytoplankton density. A multivariate analysis revealed that there was a significant difference in copepod community structure between inside and outside the port; outside the port, the community was more diverse, and the native T. stylifera was more abundant. We found that tropical copepod communities inside an offshore port have low diversity, and probably have little biotic resistance against NIS invasions. Our results, combined with those previously obtained, highlight the need to study the spatial distributions of NIS and native species in pelagic environments.

  1. East is east and West is west? Management of marine bioinvasions in the Mediterranean Sea

    Science.gov (United States)

    Galil, Bella S.; Marchini, Agnese; Occhipinti-Ambrogi, Anna

    2018-02-01

    At 726 the number of recorded multicellular non indigenous species (NIS) in the Mediterranean Sea is far higher than in other European Seas. Of these, 614 have established populations in the sea. 384 are considered Erythraean NIS, the balance are mostly ship and culture-introductions. In order to effectively implement EU Regulation on the prevention and management of the introduction and spread of invasive NIS and the Marine Strategy Framework Directive in the Mediterranean Sea it is crucial that this priority pathway is appropriately managed. Three potential impediments - incomplete and inaccurate data; unknown impacts; policy mismatch - hinder implementation. Current geographical, taxonomical and impact data gaps will be reduced only by instituting harmonized standards and methodologies for monitoring NIS populations in all countries bordering the Mediterranean Sea, prioritizing bridgehead sites and dispersal hubs. The option of implementing European environmental policies concerning marine NIS in member states alone may seem expedient, but piecemeal protection is futile. Since only 9 of the 23 states bordering the Mediterranean are EU member states, the crucial element for an effective strategy for slowing the influx of NIS is policy coordination with the Regional Sea Convention (Barcelona Convention) to ensure consistency in legal rules, standards and institutional structures to address all major vectors/pathways.

  2. Low Iodine in the Follicular Lumen Caused by Cytoplasm Mis-localization of Sodium Iodide Symporter may Induce Nodular Goiter.

    Science.gov (United States)

    Huang, Huibin; Shi, Yaxiong; Liang, Bo; Cai, Huiyao; Cai, Qingyan

    2017-10-01

    Iodine is a key ingredient in the synthesis of thyroid hormones and also a major factor in the regulation of thyroid function. A local reduction of iodine content in follicular lumen leads to overexpression of local thyroid-stimulating hormone receptor (TSHr), which in turn excessively stimulates the regional thyroid tissue, and result in the formation of nodular goiter. In this study, we investigated the relationship between iodine content and sodium iodide symporter (NIS) expression by using the clinical specimens from patients with nodular goiter and explored the pathogenesis triggered by iodine deficiency in nodular goiter. In total, 28 patients were clinically histopathologically confirmed to have nodular goiter and the corresponding adjacent normal thyroid specimens were harvested simultaneously. Western blot and immunohistochemistry were performed to assay NIS expression and localization in thyrocytes of both nodular goiter and adjacent normal thyroid tissues. NIS expression mediated by iodine in follicular lumen was confirmed by follicular model in vitro. Meanwhile, radioscan with iodine-131were conducted on both nodular goiter and adjacent normal thyroid. Our data showed that NIS expression in nodular goiter was significantly higher than that in adjacent normal tissues, which was associated with low iodine in the follicular lumen. Abnormal localization of NIS and lower amount of radioactive iodine-131 were also found in nodular goiter. Our data implied that low iodine in the follicular lumen caused by cytoplasm mis-localization of NIS may induce nodular goiter.

  3. Reliable disposal without thermal treatment of sewage sludge? An association`s views; Entsorgungssicherheit ohne thermische Klaerschlammbehandlung? Aus der Sicht eines Verbandes

    Energy Technology Data Exchange (ETDEWEB)

    Melsa, A.K. [Niersverband, Viersen (Germany)

    1998-05-01

    Will the present disposal pathways still be valid in the future? Do we need alternative strategies for ensuring reliable disposal? Efficient strategies for the future should be investigated as early as possible. (orig.) [Deutsch] Behalten bisher beschrittene Entsorgungswege auch in Zukunft ihre Bedeutung? Muessen Entsorgungsalternativen zur Gewaehrleistung einer hohen Entsorgungssicherheit gewaehrleistet werden? Es gilt, sich fruehzeitig um zukunftsfaehige Strategien zu bemuehen. (orig.)

  4. Vorläufige Mitteilung über die Beschaffenheit der Ovarialtasche von Chrysochloris, Galeopithecus und Tupaja

    NARCIS (Netherlands)

    Lange, de Daniel

    1922-01-01

    Im Jahre 1917 ist in den Anatomischen Heften die bekannte und schöne Arbeit Sobotta’s erschienen über das Vorkommen und die Bedeutung der Ovarialtasche bei den Säugetieren ¹). Das Hauptergebniss dieser Arbeit ist, dass bei alien Säugetieren (vielleicht mit Ausnahne der Primaten und des Menschen) die

  5. Die Erfindung des Manuskripts

    DEFF Research Database (Denmark)

    Benne, Christian

    Die Entstehung der literarischen Moderne ging seit dem 18. Jahrhundert damit einher, dass die Anzahl literarischer Manuskripte ebenso wuchs wie deren Bedeutung. Der Buchdruck hatte die Handschrift keineswegs überflüssig gemacht, sondern provozierte im Gegenteil einen neuen, am Autographen...

  6. Gar nicht so negativ : Die funktionale Rolle von Ärger in sozialer Interaktion

    NARCIS (Netherlands)

    Sasse, Julia; Spears, Russell; Gordijn, Ernestine H.

    2016-01-01

    Ärger wird traditionell als negative Emotion klassifiziert. Die Effekte, die Ärger in sozialer Interaktion erzielen kann, können aber durchaus positive sein – es kommt ganz auf die Umstände an. Grundlegend für das Verständnis der Bedeutung von Ärger aber auch anderen Emotionen in sozialer

  7. Rezension: Ada Lovelace. Die Pionierin der Computertechnik und ihre Nachfolgerinnen von Sybille Krämer (Hg.

    Directory of Open Access Journals (Sweden)

    Bettina Schabschneider

    2015-12-01

    Full Text Available Ein aktueller von Sybille Krämer herausgegebener Sammelband beleuchtet die Bedeutung der Computertechnik-Pionierin Ada Lovelace. Bettina Schabschneider hat den Band einer detaillierten Lektüre unterzogen und für die MEDIENIMPULSE rezensiert …

  8. Review Essay: Spiegelneuronen in der sozialwissenschaftlichen Diskussion

    OpenAIRE

    Pätzold, Henning

    2010-01-01

    Seit ihrer Entdeckung Mitte der 1990er Jahre sind Spiegelneuronen kontinuierlicher Gegenstand neuro- wie sozialwissenschaftlicher Debatten. Das besondere Interesse von Wissenschaftler/innen außerhalb der biologischen Disziplinen beruht auch darauf, dass Spiegelneuronen nicht nur allgemeine erkenntnistheoretische Bedeutung haben, sondern auch im Zusammenhang mit fundamentalen sozialen Erkenntnis- und Empfindungsformen wie Empathie eine wichtige Rolle zu spielen scheinen. Mit dem Buch von Nadia...

  9. Die Suche nach den Gottesteilchen

    CERN Multimedia

    2007-01-01

    2008 wird der größte jemals gebaute Teilchenbeschleuniger in Betrieb genommen Anlässlich des Mathematik-Jahres 2008 hat der Experimentalphysiker der Universität Hamburg und der designierte Generaldirektor des europäischen Zentrums für Teilchenphysik CERN in Genf, Rolf-Dieter Heuer, die Bedeutung des Dialogs zwischen Naturwissenschaftlern und Philosophen hervorgehoben.

  10. Unbehaglich

    Directory of Open Access Journals (Sweden)

    Diemut Majer

    2012-01-01

    Full Text Available Rezension von: Gaby Temme und Christine Künzel (Hg., Hat Strafrecht ein Geschlecht? Zur Deutung und Bedeutung der Kategorie Geschlecht in strafrechtlichen Diskursen vom 18. Jahrhundert bis heute, Bielefeld: Transcript 2010, 275 S., ISBN 978-3-8376-1384-1

  11. A massive update of non-indigenous species records in Mediterranean marinas

    Directory of Open Access Journals (Sweden)

    Aylin Ulman

    2017-10-01

    Full Text Available The Mediterranean Sea is home to over 2/3 of the world’s charter boat traffic and hosts an estimated 1.5 million recreational boats. Studies elsewhere have demonstrated marinas as important hubs for the stepping-stone transfer of non-indigenous species (NIS, but these unique anthropogenic, and typically artificial habitats have largely gone overlooked in the Mediterranean as sources of NIS hot-spots. From April 2015 to November 2016, 34 marinas were sampled across the following Mediterranean countries: Spain, France, Italy, Malta, Greece, Turkey and Cyprus to investigate the NIS presence and richness in the specialized hard substrate material of these marina habitats. All macroinvertebrate taxa were collected and identified. Additionally, fouling samples were collected from approximately 600 boat-hulls from 25 of these marinas to determine if boats host diverse NIS not present in the marina. Here, we present data revealing that Mediterranean marinas indeed act as major hubs for the transfer of marine NIS, and we also provide evidence that recreational boats act as effective vectors of spread. From this wide-ranging geographical study, we report here numerous new NIS records at the basin, subregional, country and locality level. At the basin level, we report three NIS new to the Mediterranean Sea (Achelia sawayai sensu lato, Aorides longimerus, Cymodoce aff. fuscina, and the re-appearance of two NIS previously known but currently considered extinct in the Mediterranean (Bemlos leptocheirus, Saccostrea glomerata. We also compellingly update the distributions of many NIS in the Mediterranean Sea showing some recent spreading; we provide details for 11 new subregional records for NIS (Watersipora arcuata, Hydroides brachyacantha sensu lato and Saccostrea glomerata now present in the Western Mediterranean; Symplegma brakenhielmi, Stenothoe georgiana, Spirobranchus tertaceros sensu lato, Dendostrea folium sensu lato and Parasmittina egyptiaca now

  12. Atsevišķu latviešu un lietuviešu valodas adjektīvu semantiskā diferenciācija: latv. šķīsts, liet. skýstas; latv. skaists, liet. skaistùs; latv. tikls, liet. tiklùs

    Directory of Open Access Journals (Sweden)

    Anta Trumpa

    2011-11-01

    Full Text Available Die semantische differenziation von manchen adjektiven der lettischen und litauischen sprache: lett. šķīsts, lit. skýstas; lett, skaists, lit. skaistùs; lett, tikls, lit. tiklùsZusammenfassungDiesen Wortpaaren von semantisch unterschiedlichen Adjektiven der lettischen und litauischen Spra­che (lett. šķīsts ‘tugendhaft, unschuldig, keusch’ : lit. skýstas ‘flüssig; nicht ernst gemeint, unreif’; lett. skaists ‘schön’ : lit. skaistùs ‘grell, klar, rosig; ehrlich, keusch’; lett. tikls ‘tugendhaft, keusch’ : lit. tiklùs ‘treu, leichtgläubig; ehrlich, anständig’ kann man zu Bezeichnungen der Eigenschaften der Sit­tlichkeit zählen, weil mindestens ein Wort im Paar (lett. šķīsts, lett. tikls, lit. tiklùs und lit. skaistùs eine mit Sittlichkeit verbündete Eigenschaft charakterisiert.Die Aufgabe dieses Artikels ist mit der Analyse von diesen Wortpaaren zu konstatieren, welche Sprache die ältere Bedeutung beibehaltet hat, ungefähre Ursachen der Bedeutungsveränderung festzu­stellen und zu bestimmen, ob sie für ganze Gruppe charakteristisch sind.Lit. skýstas hat die ältere Bedeutung ‘flüssig’ beibehaltet. Im Lettischen war anfänglich zwei Be­deutungen: ‘flüssig’ (in Mundarten und ‘rein, sauber’. Die erste Bedeutung ist noch in unseren Zeiten nur als die Erscheinung der Mundarten erhalten worden, aber in der Schriftsprache ist vielleicht wegen des Einflusses der religiösen Texten die Bedeutungsverengung ‘sauber, rein’ → ‘rein von Sünden, tu­gendhaft, keusch’ geschehen.Mehrdeutiges lit. skaistùs hat vermutlich auch die ältere Bedeutung ‘klar, hell’ beibehaltet, aber die Bedeutung ‘tugendhaft, keusch’ hat sich voraussichtlich als übertragene Bedeutung von der Bedeutung ‘rein, hell’ entwickelt und heute ist sie nicht besonders oft verwendet. Im Lettischen ist die Bedeutungs­veränderung ‘hell’ → ‘schön’ geschehen und ist vermutlich die

  13. Genetically targeted radiotherapy using the sodium-iodide symporter for treatment of head and neck cancer

    International Nuclear Information System (INIS)

    Gaut, A.W.; Niu, G.; Graham, M.M.; Domann, F.E.; Krager, K.J.

    2003-01-01

    Attempts at using gene therapy for cancer treatment have achieved limited success. Traditional in vivo gene therapy techniques are limited by relatively inefficient gene transfer, with only a small fraction of tumor cells transfected with the gene of interest. Gene therapy strategies yielding substantial bystander cytotoxicity are preferable and could yield significant clinical effect despite a lack of gene transfer to the entire tumor. We report the successful use of such a strategy in head and neck squamous cell carcinoma (HNSCC) cell lines. The sodium iodide symporter (NIS) gene, expressed primarily in the thyroid, is responsible for physiologic iodide accumulation. Expression of NIS in non-thyroid cell lines has been shown to confer iodide-concentrating ability. Using a recombinant adenovirus-NIS construct (Ad-NIS) delivered to HNSCC cell lines, we demonstrate radioiodide accumulation 15- to 30-fold higher than that of cell lines transduced with a control (Ad-Bgl II) adenovirus. Consistent with NIS-mediated uptake, this accumulation is inhibited by treatment with perchlorate. Using a clonogenic cell survival assay, we demonstrate a statistically significant, dose-dependent decrease in cell survival after delivery of Ad-NIS followed by administration of varying doses of I-131. Compared to a control, Ad-Bgl II-treated group, absolute survival was reduced by 80% at the highest dose of I-131 in Ad-NIS-treated cells. We also demonstrate the ability of NIS gene transfer followed by systemic administration of I-131 to dramatically attenuate tumor formation in nude mice. Three weeks after subcutaneous injection of tumor cells, tumors treated with Ad-NIS had decreased in size by 0.7±0.1 mm, whereas control tumors treated with Ad-Bgl II had increased in size by 7.4±1.7 mm. The relative accessibility of head and neck cancers make them attractive targets for gene therapy. Our data demonstrate the feasibility of genetically targeted radiotherapy using the NIS gene as a

  14. Nosocomial infections at Clinical Centre in Kragujevac: Prevalence study

    Directory of Open Access Journals (Sweden)

    Ilić Milena

    2010-01-01

    Full Text Available Introduction Nosocomial infections (NIs are a serious health problem in hospitals worldwide and are followed by a series of consequences, medical, judicial, ethical and economic. Objective The main aim of this study was to assess the magnitude of NIs at the Clinical Centre in Kragujevac. Methods A prevalence study of nosocomial infections was conducted from 16th till 20th May, 2005, within Second National Prevalence Study of Niš in the Republic of Serbia. Results The study included 866 patients. 40 patients had a NI, thus the prevalence of patients with NIs and prevalence of NIs was the same, 4.6%. Among NIs, the most frequent were urinary infections (45.0% followed by surgical-site infections (17.5%, skin and soft tissue infections (15% and pneumonia (12.5%. The rate of NIs was highest at departments of orthopaedics and traumatological surgery (12.0%, followed by intensive care units (8.0%. Overall, 67.5% (27/40 NIs were culture-proved; the leading pathogens were Escherichia coli (40.0%, followed by gram-negative bacteria (Pseudomonas species, Proteus mirabilis, Enterobacteriaceae with equal frequency of 8.0%. Nosocomial infections were significantly more frequent in patients aged ≥65 years (p<0.05, with longer hospitalization ≥8 days (p<0.00, in intensive care patients (p<0.05, patients with an intravenous catheter (p<0.00, urinary catheter (p<0.00, and those under antibiotic therapy (p<0.00. Conclusion This study showed that the prevalence of nosocomial infections in our hospital is similar to the prevalence in the developed countries. The study of prevalence provides a prompt insight into basic epidemiological and ethiological characteristics of nosocomial infections, hence identification of hospital priorities and the need to undertake appropriate prevention measures. .

  15. Feasibility of baculovirus-mediated reporter gene delivery for efficient monitoring of islet transplantation in vivo

    International Nuclear Information System (INIS)

    Liu, Shuai; Pan, Yu; Lv, Jing; Wu, Haifei; Tian, Jingyan; Zhang, Yifan

    2014-01-01

    Objective: The objective of this study was to explore the feasibility of baculovirus vector-mediated sodium iodide symporter (NIS) gene delivery to monitor islet transplantation. Methods: Baculovirus vectors expressing green fluorescent protein (GFP) or NIS (Bac-GFP and Bac-NIS) were established using the Bac-to-Bac baculovirus expression system. The GFP expression of Bac-GFP-infected rat islets was observed in vitro by fluorescence microscopy. Iodine uptake and inhibition of iodine uptake by NaClO 4 in Bac-NIS-infected islets were dynamically monitored in vitro. Bac-GFP- or Bac-NIS-infected islets were implanted into the left axillary cavity of NOD-SCID mice, and fluorescence imaging and 125 I NanoSPECT/CT imaging were subsequently performed in vivo. Results: Bac-GFP efficiently infected rat islets (over 95% infected at MOI = 40), and the expression of GFP lasted approximately two weeks. NaClO 4 could inhibit iodine uptake by Bac-NIS-infected islets. In vivo imaging revealed that the fluorescence intensity of the transplant sites in Bac-GFP-infected groups was significantly higher than in the non-infected group. Grafts could be clearly observed by 125 I NanoSPECT/CT imaging for up to 8 h. Conclusion: Baculovirus vectors are powerful vehicles for studying rat islets in gene delivery. It is feasible to use a baculovirus vector to delivery an NIS gene for non-invasive monitoring transplanted islets in vivo by the expression of the target gene

  16. Comparison of Na{sup +}/I{sup -} symporter expression rate in malignant and benign thyroid diseases: immunohistochemical study

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Do Young; Jeong, Young Jin; Lee, Kyung Eun; Park, Heon Soo; Yoo, Young Hyun; Roh, Mee Sook [Donga University College of Medicine, Busan (Korea, Republic of)

    2006-02-15

    Previous studies have not showed consistent results for the level of expression of sodium/iodide symporter (NIS) in thyroid diseases, especially malignant tumor. We undertook this study to evaluate the distribution of NIS expression in malignant thyroid diseases and compare with that in benign thyoid disease. Total patients were 119 cases (Men 15, 48{+-}13 yrs). Total number of samples were 205 pieces. In malignant thyroid disease, there were 153 samples: 90 in papillary carcinoma, 4 in follicular carcinoma, 2 in medullary carcinoma and 57 in metastatic lymph node. In benign thyroid disease, there were 52 samples: 36 in goiter/cyst, 11 in thyroiditis and 5 in follicular adenoma. Using immunohistochemical methods, we probed 205 samples with monoclonal anti-NIS Ab. Grading of staining was scored as 0 (negative or absent), 1 (weakly positive), 2 (moderately positive) or 3 (strongly positive). Expression rate (ER) of NIS positivity in individual disease entity was expressed as percentage of total number divided by number in 2 plus 3 grade. ERs of malignant thyroid diseases were 63% in papillary carcinoma, 81% in metastatic lymph node, 71% in follicular carcinoma and 100% in medullary carcinoma. ERs of benign thyroid disease were 53% in goiter/cyst, 64% in thyroiditis and 40% in follicular adenoma. ER of benign thyroid deceases was higher than benign thyroid diseases (71% vs 54%). Grading of NIS expression in papillary carcinoma or goiter/cyst was heterogeneously distributed in considerable cases. Normal tissue also showed heterogeneous distribution or NIS expression, which was not correlated with that of primary lesion. In papillary thyroid carcinoma, distribution of NIS expression was heterogeneous and increased, and not different compared with that of benign thyroid disease.

  17. Comparison of Na+/I- symporter expression rate in malignant and benign thyroid diseases: immunohistochemical study

    International Nuclear Information System (INIS)

    Kang, Do Young; Jeong, Young Jin; Lee, Kyung Eun; Park, Heon Soo; Yoo, Young Hyun; Roh, Mee Sook

    2006-01-01

    Previous studies have not showed consistent results for the level of expression of sodium/iodide symporter (NIS) in thyroid diseases, especially malignant tumor. We undertook this study to evaluate the distribution of NIS expression in malignant thyroid diseases and compare with that in benign thyoid disease. Total patients were 119 cases (Men 15, 48±13 yrs). Total number of samples were 205 pieces. In malignant thyroid disease, there were 153 samples: 90 in papillary carcinoma, 4 in follicular carcinoma, 2 in medullary carcinoma and 57 in metastatic lymph node. In benign thyroid disease, there were 52 samples: 36 in goiter/cyst, 11 in thyroiditis and 5 in follicular adenoma. Using immunohistochemical methods, we probed 205 samples with monoclonal anti-NIS Ab. Grading of staining was scored as 0 (negative or absent), 1 (weakly positive), 2 (moderately positive) or 3 (strongly positive). Expression rate (ER) of NIS positivity in individual disease entity was expressed as percentage of total number divided by number in 2 plus 3 grade. ERs of malignant thyroid diseases were 63% in papillary carcinoma, 81% in metastatic lymph node, 71% in follicular carcinoma and 100% in medullary carcinoma. ERs of benign thyroid disease were 53% in goiter/cyst, 64% in thyroiditis and 40% in follicular adenoma. ER of benign thyroid deceases was higher than benign thyroid diseases (71% vs 54%). Grading of NIS expression in papillary carcinoma or goiter/cyst was heterogeneously distributed in considerable cases. Normal tissue also showed heterogeneous distribution or NIS expression, which was not correlated with that of primary lesion. In papillary thyroid carcinoma, distribution of NIS expression was heterogeneous and increased, and not different compared with that of benign thyroid disease

  18. Effect of Co-overexpression of Nisin Key Genes on Nisin Production Improvement in Lactococcus lactis LS01.

    Science.gov (United States)

    Ni, Zhi-Jian; Zhang, Xiao-Yuan; Liu, Fei; Wang, Miao; Hao, Rong-Hua; Ling, Pei-Xue; Zhu, Xi-Qiang

    2017-06-01

    Nisin is a small antimicrobial peptide produced by several subset strains of Lactococcus lactis. To improve nisin yield in the producer L. lactis LS01, we proposed a successive fusion of nisA with nisRK and nisFEG into a single shuttle expression vector pMG36e under the control of the native strong constitutive promoter p32. Subsequently, the recombinant vectors were transplanted into the producer cell through electroporation. Nisin productivity was determined through sodium dodecyl sulfate-polyacrylamide gel electrophoresis and bioactivity assays. Expression of nisin peptide was detected by agar diffusion bioassay, and the transcriptional levels of the target genes involved in nisin biosynthesis were investigated via semi-quantitative reverse transcription PCR expression analysis using 16S ribosomal RNA (rRNA) as an internal control. Results suggested that the introduction of empty plasmid did not affect nisin production of L. lactis LS01, whereas by our rational construction and screening, the engineered strain co-overexpressing nisA, nisRK, and nisFEG achieved a maximum increment in bioactive nisin production with a yield of 2470 IU/ml in shake flasks and 4857 IU/ml in 1.0-l fermenters, which increased by approximately 66.3 and 52.6% (P < 0.05), respectively, compared with that of the original strain under the given fermentation conditions. Meanwhile, the transcriptional analysis revealed that the expression of most of these multicopy genes except nisE at transcriptional level were upregulated in the two recombinant strains (LS01/pAR and LS01/pARF), possibly contributing to the improved nisin production. Therefore, this study would provide a potential strategy to improve the economic benefits of nisin manufacture for large-scale industrial production.

  19. One year study of bacterial and fungal nosocomial infections among patients in pediatric intensive care unit (PICU) in Alexandria.

    Science.gov (United States)

    El-Nawawy, Ahmed Ahmed; Abd El-Fattah, Mohamed Mohamed; Metwally, Hala Abd El-Raouf; Barakat, Shahira Salah El Din; Hassan, Ihab Abdel Rehim

    2006-06-01

    A 1-year prospective and observational study included all admissions (n=216) until 48 h after discharge to Alexandria PICU between first of May 2003 and end of April 2004. Cultures for bacteria and fungi and antibiotic sensitivity tests (19 antibiotic using Bauer-Kirby disc diffusion method) were obtained (blood, stool, urine and cerebrospinal fluid, if needed) and repeated on suspicion of NIs. All cannulae, endotracheal tube (ET) aspirates and tips, nasogastric tubes and different catheters were cultured. All PICU health care workers (HCWs) were subjected to throat and under-finger nails cultures as well as inanimate objects, both on bimonthly basis. The referral place (ward or emergency), PRISM III score, length of stay (LOS) and fate were recorded. Amongst those patients whose age ranged from 1 to 23 months, 23 per cent had NIs with infection rates of 40/1000 days. Significantly high rates of mortality, LOS and PRISM III score were encountered among patients with NIs (52 per cent vs 30 per cent; 9.4+/-4.8 vs 5.4+/-2.2 days; 14.4+/-7 vs 11.8+/-6 respectively). The descending order of frequency of NIs was blood stream infection (BSI) (47 per cent), urinary tract infection (UTI) (28 per cent), ventilator-associated pneumonia (VAP) (16 per cent) and meningitis (9 per cent). Gr-ve bacilli accounted for 76.7 per cent; Gr+ve cocci 13.3 per cent (with satisfactory sensitivity to cefepime, imipenem and meropenem) and Candida albicans 10 per cent of all NIs. The rate of NIs/1000 device days were: 18.7 per cent for BSI, 10.9 per cent for VAP and 25.5 per cent for UTI. Vulnerable age groups were >6 m for VAP and predictors of NI acquisition (odd ratio and 95 per cent confidence interval: 1.537, 1.423-1.659; 1.073, 1.041-1.105 and 0.269, 0.178-0.406 respectively). Bimonthly cultures for HCWs isolated coagulase-ve Staphylococci, while inanimate objects isolated diphtheroids and Candida albicans. NIs rate was high (23 per cent) mainly due to severity of condition on admission

  20. Should Israel screen all mothers-to-be to prevent early-onset of neonatal group B streptococcal disease? A cost-utility analysis

    Directory of Open Access Journals (Sweden)

    Ginsberg Gary M

    2013-02-01

    Full Text Available Abstract Background In Israel, an average of 37 children are born each year with sepsis and another four with meningitis as a result of Group B Streptococcal (GBS disease. Israel currently only screens mothers with defined risk factors (around 15% of all pregnancies in order to identify candidates for Intrapartum Antiobiotic Prophyhlaxis (IAP of GBS. This paper presents a cost-utility analysis of implementing an alternative strategy, which would expand the current protocol to one aiming to screen all pregnant women at 35–37 weeks gestation based on taking a vaginal culture for GBS. Methods A spreadsheet model was built incorporating technical, epidemiological, health service costs, demographic and economic data based primarily on Israeli sources. Results The intervention of universal screening (compared with the current scenario would increase screening costs from 580,000 NIS to 3,278,000 million NIS. In addition, the intervention would also increase penicillin costs from 39,000 NIS to 221,000 NIS. Current culture screening of approximately 15% of mothers-to-be with high risk factors resulted in 42 GBS births in 2008-9 (0.253/1000 births. Expanding culture screening to 85% of mothers-to-be, will decrease the number of GBS births to 17.3 (0.104/1000 births. The initial 2.9 million NIS incremental intervention costs are offset by decreased treatment costs of 1.9 million NIS and work productivity gains of 811,000 NIS as a result of a decrease in neurological sequelae from GBS caused meningitis. Thus the resultant net cost of the intervention is only around 134,000 NIS. Culture based screening will reduce the burden of disease by 12.6 discounted Quality Adjusted Life Years (QALYS, giving a very cost effective baseline incremental cost per QALY (cf. risk factor screening of 10,641 NIS per QALY. The data was very sensitive to rates of anaphylactic shock and changes in the percentage of meningitis cases that had associated long term

  1. Should Israel screen all mothers-to-be to prevent early-onset of neonatal group B streptococcal disease? A cost-utility analysis.

    Science.gov (United States)

    Ginsberg, Gary M; Eidelman, Arthur I; Shinwell, Eric; Anis, Emilia; Peyser, Reuven; Lotan, Yoram

    2013-02-20

    In Israel, an average of 37 children are born each year with sepsis and another four with meningitis as a result of Group B Streptococcal (GBS) disease. Israel currently only screens mothers with defined risk factors (around 15% of all pregnancies) in order to identify candidates for Intrapartum Antiobiotic Prophyhlaxis (IAP) of GBS. This paper presents a cost-utility analysis of implementing an alternative strategy, which would expand the current protocol to one aiming to screen all pregnant women at 35-37 weeks gestation based on taking a vaginal culture for GBS. A spreadsheet model was built incorporating technical, epidemiological, health service costs, demographic and economic data based primarily on Israeli sources. The intervention of universal screening (compared with the current scenario) would increase screening costs from 580,000 NIS to 3,278,000 million NIS. In addition, the intervention would also increase penicillin costs from 39,000 NIS to 221,000 NIS. Current culture screening of approximately 15% of mothers-to-be with high risk factors resulted in 42 GBS births in 2008-9 (0.253/1000 births). Expanding culture screening to 85% of mothers-to-be, will decrease the number of GBS births to 17.3 (0.104/1000 births). The initial 2.9 million NIS incremental intervention costs are offset by decreased treatment costs of 1.9 million NIS and work productivity gains of 811,000 NIS as a result of a decrease in neurological sequelae from GBS caused meningitis. Thus the resultant net cost of the intervention is only around 134,000 NIS. Culture based screening will reduce the burden of disease by 12.6 discounted Quality Adjusted Life Years (QALYS), giving a very cost effective baseline incremental cost per QALY (cf. risk factor screening) of 10,641 NIS per QALY. The data was very sensitive to rates of anaphylactic shock and changes in the percentage of meningitis cases that had associated long term-sequelae. It is recommended that Israel adopt universal culture

  2. The feasibility of using a baculovirus vector to deliver the sodium-iodide symporter gene as a reporter

    Energy Technology Data Exchange (ETDEWEB)

    Zhou Xiang; Li Biao; Wang Jun; Yin Hongyan [Department of Nuclear Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025 (China); Zhang Yifan [Department of Nuclear Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025 (China)], E-mail: zhangyifan1992@yahoo.com.cn

    2010-04-15

    Purpose: To evaluate the efficiency of baculovirus vectors in transducing FTC-133 cells and to examine the feasibility of using baculovirus vectors for the delivery of the sodium-iodide symporter (NIS) gene as a reporter through co-transduction to monitor the expression of the target gene. Method: Two recombinant baculoviruses were constructed to express NIS and green fluorescent protein (GFP) respectively. FTC-133, 8050C, SW1116, A549 cells, were infected with Bac-GFP. The infection efficiency of Bac-GFP and the intensity of fluorescence, in either the presence or absence of sodium butyrate, were monitored by flow cytometry. The iodine uptake by FTC-133 cells infected with Bac-NIS was measured using a {gamma} counter. FTC-133 cells were infected with a mixture of equal amounts of Bac-NIS and Bac-GFP at different setting of multiplicity of infection (MOI). The changes of GFP fluorescence intensity and iodine uptake were monitored 24 h after infection in the coinfected cells. Results: We have successfully constructed recombinant baculoviruses carrying NIS and GFP under the control of the cytomegalovirus IE-1 promoter. We found that transduced efficiency of baculovirus in 8505C, SW1116, A549 cells are low in absence of sodium butyrate. Yet Bac-GFP infects FTC-133 cells at a high efficiency, 77.67%, 85.57% and 93.23% with MOI of 100, 200 and 400, respectively. The fluorescence intensity of the Bac-GFP infected tumor cells correlated positively with the MOI of the virus. Sodium butyrate induction increased both the infection efficiency and the fluorescence intensity, but increase of infection efficiency was insignificant in FTC-133 cells. Reporter gene (GFP) expression in FTC-133 is stable within 7 days after infection. The radioactivity incorporated by the tumor cells infected with Bac-NIS correlated positively with the MOI of Bac-NIS as well. In tumor cells co-infected with Bac-NIS and Bac-GFP, the amount of radioactivity incorporated significantly correlated with

  3. Reducing the cesarean delivery rates for breech presentations: administration of spinal anesthesia facilitates manipulation to cephalic presentation, but is it cost saving?

    Science.gov (United States)

    2014-01-01

    Background External cephalic version (ECV) is infrequently performed and 98% of breech presenting fetuses are delivered surgically. Neuraxial analgesia can increase the success rate of ECV significantly, potentially reducing cesarean delivery rates for breech presentation. The current study aims to determine whether the additional cost to the hospital of spinal anesthesia for ECV is offset by cost savings generated by reduced cesarean delivery. Methods In our tertiary hospital, three variables manpower, disposables, and fixed costs were calculated for ECV, ECV plus anesthetic doses of spinal block, vaginal delivery and cesarean delivery. Total procedure costs were compared for possible delivery pathways. Manpower data were obtained from management payroll, fixed costs by calculating cost/lifetime usage rate and disposables were micro-costed in 2008, expressed in 2013 NIS. Results Cesarean delivery is the most expensive option, 11670.54 NIS and vaginal delivery following successful ECV under spinal block costs 5497.2 NIS. ECV alone costs 960.21 NIS, ECV plus spinal anesthesia costs 1386.97 NIS. The highest individual cost items for vaginal, cesarean delivery and ECV were for manpower. Expensive fixed costs for cesarean delivery included operating room trays and postnatal hospitalization (minimum 3 days). ECV with spinal block is cheaper due to lower expected cesarean delivery rate and its lower associated costs. Conclusions The additional cost of the spinal anesthesia is offset by increased success rates for the ECV procedure resulting in reduction in the cesarean delivery rate. PMID:24564984

  4. Concentrations of neonicotinoid insecticides in honey, pollen and honey bees (Apis mellifera L.) in central Saskatchewan, Canada.

    Science.gov (United States)

    Codling, Garry; Al Naggar, Yahya; Giesy, John P; Robertson, Albert J

    2016-02-01

    Neonicotinoid insecticides (NIs) and their transformation products were detected in honey, pollen and honey bees, (Apis mellifera) from hives located within 30 km of the City of Saskatoon, Saskatchewan, Canada. Clothianidin and thiamethoxam were the most frequently detected NIs, found in 68 and 75% of honey samples at mean concentrations of 8.2 and 17.2 ng g(-1) wet mass, (wm), respectively. Clothianidin was also found in >50% of samples of bees and pollen. Concentrations of clothianidin in bees exceed the LD50 in 2 of 28 samples, while for other NIs concentrations were typically 10-100-fold less than the oral LD50. Imidaclorpid was detected in ∼30% of samples of honey, but only 5% of pollen and concentrations were NIs. Results of an assessment of the potential dietary uptake of NIs from honey and pollen by bees over winter, during which worker bees live longer than in summer, suggested that, in some hives, consumption of honey and pollen during over-wintering might have adverse effects on bees. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. Comparison of the Effects of Phenylhydrazine Hydrochloride and Dicyandiamide on Ammonia-Oxidizing Bacteria and Archaea in Andosols

    Directory of Open Access Journals (Sweden)

    Wenjie Yang

    2017-11-01

    Full Text Available Dicyandiamide, a routinely used commercial nitrification inhibitor (NI, inhibits ammonia oxidation catalyzed by ammonia monooxygenase (AMO. Phenylhydrazine hydrochloride has shown considerable potential for the development of next-generation NIs targeting hydroxylamine dehydrogenase (HAO. The effects of the AMO inhibitor and the HAO inhibitor on ammonia-oxidizing bacteria (AOB and ammonia-oxidizing archaea (AOA present in agricultural soils have not been compared thus far. In the present study, the effects of the two inhibitors on soil nitrification and the abundance of AOA and AOB as well as their community structure were investigated in a soil microcosm using quantitative polymerase chain reaction and pyrosequencing. The net nitrification rates and the growth of AOA and AOB in this soil microcosm were inhibited by both NIs. Both NIs had limited effect on the community structure of AOB and no effect on that of AOA in this soil microcosm. The effects of phenylhydrazine hydrochloride were similar to those of dicyandiamide. These results indicated that organohydrazine-based NIs have potential for the development of next-generation NIs targeting HAO in the future.

  6. Impacts of aquatic nonindigenous invasive species on the Lake Erie ecosystem

    Science.gov (United States)

    Austen, Madeline J.W.; Ciborowski, Jan J.H.; Corkum, Lynda D.; Johnson, Tim B.; MacIsaac, Hugh J.; Metcalfe-Smith, Janice L.; Schloesser, Donald W.; George, Sandra E.

    2002-01-01

    Lake Erie is particularly vulnerable to the introduction and establishment of aquatic nonindigenous invasive species (NIS) populations. A minimum of 144 aquatic NIS have been recorded in the Lake Erie basin including several species [e.g., Eurasian watermilfoil (Myriophyllum spicatum); zebra mussel (Dreissena polymorpha); quagga mussel (Dreissena bugensis); an amphipod (Echinogammarus ischnus); round goby (Neogobius melanostomus); and sea lamprey (Petromyzon marinus)] that have had discernible impacts on the lake's ecology. NIS pose threats to the Lake Erie ecosystem for a variety of reasons including their ability to proliferate quickly, compete with native species, and transfer contaminants (e.g., PCBs) and disease through the food web. Six of the 14 beneficial use impairments listed in Annex 2 of the Great Lakes Water Quality Agreement are impaired in Lake Erie, in part as a result of the introduction of NIS. The Lake Erie Lakewide Management Plan (LaMP) has adopted an ecosystem approach to restore beneficial use impairments in the lake. Furthermore, a research consortium, known as the Lake Erie Millennium Network, is working alongside the LaMP, to address research problems regarding NIS, the loss of habitat, and the role of contaminants in the Lake Erie ecosystem.

  7. Progress in Gene Therapy for Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Ahmed, Kamran A.; Davis, Brian J. [Department of Radiation Oncology, Mayo Clinic, Rochester, MN (United States); Wilson, Torrence M. [Department of Urology, Mayo Clinic, Rochester, MN (United States); Wiseman, Gregory A. [Division of Nuclear Medicine, Mayo Clinic, Rochester, MN (United States); Federspiel, Mark J. [Department of Molecular Medicine, Mayo Clinic, Rochester, MN (United States); Morris, John C., E-mail: davis.brian@mayo.edu [Division of Endocrinology, Mayo Clinic, Rochester, MN (United States)

    2012-11-19

    Gene therapy has held promise to correct various disease processes. Prostate cancer represents the second leading cause of cancer death in American men. A number of clinical trials involving gene therapy for the treatment of prostate cancer have been reported. The ability to efficiently transduce tumors with effective levels of therapeutic genes has been identified as a fundamental barrier to effective cancer gene therapy. The approach utilizing gene therapy in prostate cancer patients at our institution attempts to address this deficiency. The sodium-iodide symporter (NIS) is responsible for the ability of the thyroid gland to transport and concentrate iodide. The characteristics of the NIS gene suggest that it could represent an ideal therapeutic gene for cancer therapy. Published results from Mayo Clinic researchers have indicated several important successes with the use of the NIS gene and prostate gene therapy. Studies have demonstrated that transfer of the human NIS gene into prostate cancer using adenovirus vectors in vitro and in vivo results in efficient uptake of radioactive iodine and significant tumor growth delay with prolongation of survival. Preclinical successes have culminated in the opening of a phase I trial for patients with advanced prostate disease which is currently accruing patients. Further study will reveal the clinical promise of NIS gene therapy in the treatment of prostate as well as other malignancies.

  8. Progress in Gene Therapy for Prostate Cancer

    International Nuclear Information System (INIS)

    Ahmed, Kamran A.; Davis, Brian J.; Wilson, Torrence M.; Wiseman, Gregory A.; Federspiel, Mark J.; Morris, John C.

    2012-01-01

    Gene therapy has held promise to correct various disease processes. Prostate cancer represents the second leading cause of cancer death in American men. A number of clinical trials involving gene therapy for the treatment of prostate cancer have been reported. The ability to efficiently transduce tumors with effective levels of therapeutic genes has been identified as a fundamental barrier to effective cancer gene therapy. The approach utilizing gene therapy in prostate cancer patients at our institution attempts to address this deficiency. The sodium-iodide symporter (NIS) is responsible for the ability of the thyroid gland to transport and concentrate iodide. The characteristics of the NIS gene suggest that it could represent an ideal therapeutic gene for cancer therapy. Published results from Mayo Clinic researchers have indicated several important successes with the use of the NIS gene and prostate gene therapy. Studies have demonstrated that transfer of the human NIS gene into prostate cancer using adenovirus vectors in vitro and in vivo results in efficient uptake of radioactive iodine and significant tumor growth delay with prolongation of survival. Preclinical successes have culminated in the opening of a phase I trial for patients with advanced prostate disease which is currently accruing patients. Further study will reveal the clinical promise of NIS gene therapy in the treatment of prostate as well as other malignancies.

  9. Decreased solar radiation and increased temperature combine to facilitate fouling by marine non-indigenous species.

    Science.gov (United States)

    Kim, Tae Won; Micheli, Fiorenza

    2013-01-01

    Studies of the effects of climate changes on marine biofouling have mainly focused on the effects of temperature increase, but a decrease in the level of solar radiation could also influence the establishment and persistence of fouling species. To test if decreased solar radiation and/or increased temperature influenced marine fouling communities, solar radiation, and temperature were manipulated by deploying shading devices in the intertidal zone of a central California estuary. Non-indigenous species (NIS) recruiting to artificial substrata had greater coverage under the shading treatments than under transparent plates, indicating that low radiation facilitates recruitment and growth of NIS. In contrast, the coverage of NIS underneath warmer black plates was higher than that on white plates. Furthermore, spatial comparisons of recruitment showed that NIS had a tendency to grow better in the warmer region of the estuary whereas native species showed the opposing trend. The results suggest that both lower radiation and higher temperature may facilitate the spread of marine NIS.

  10. Mammary radioiodine accumulation due to functional sodium iodide symporter expression in a benign fibroadenoma

    International Nuclear Information System (INIS)

    Berger, F.; Unterholzner, S.; Diebold, J.; Knesewitsch, P.; Hahn, K.; Spitzweg, C.

    2006-01-01

    The sodium iodide symporter (NIS) has been characterized to mediate the active transport of iodide not only in the thyroid gland but also in various non-thyroidal tissues, including lactating mammary gland and the majority of breast cancers, thereby offering the possibility of diagnostic and therapeutic radioiodine application in breast cancer. In this report, we present a 57-year-old patient with multifocal papillary thyroid carcinoma, who showed focal radioiodine accumulation in a lesion in the right breast on a posttherapy 131 I scan following radioiodine therapy. CT and MR-mammography showed a focal solid lesion in the right breast suggestive of a fibroadenoma, which was confirmed by histological examination. Immunostaining of paraffin-embedded tumor tissue sections using a human NIS antibody demonstrated NIS-specific immunoreactivity confined to epithelial cells of mammary ducts. In conclusion, in a thyroid cancer patient we identified a benign fibroadenoma of the breast expressing high levels of functionally active NIS protein as underlying cause of focal mammary radioiodine accumulation on a posttherapy 131 I scan. These data show for the first time that functional NIS expression is not restricted to lactating mammary gland and malignant breast tissue, but can also be detected in benign breast lesions, such as fibroadenomata of the breast

  11. Extracellular requirements for the endocytosis of carcinogenic crystalline nickel sulfide particles by facultative phagocytes

    International Nuclear Information System (INIS)

    Heck, J.D.; Costa, M.

    1982-01-01

    Various culture medium components were examined for their effect upon the phagocytosis of carcinogenic crystalline and non-carcinogenic amorphous NiS by cultured fibroblastic cells using both a visual and radioactive assay for phagocytosis. Crystalline 63 NiS was phagocytosed by cells in a simple salts/glucose maintenance medium to an extent similar to that observed in complex culture medium fortified with 10% fetal bovine serum (FBS), suggesting that serum proteins and other components in complex culture medium exert little influence upon the uptake of these heavy metal particles. Phagocytosis of crystalline NiS was shown to be highly dependent upon Ca 2+ since omission of Ca 2+ from the salts/glucose medium substantially reduced phagocytosis, while readdition of Ca 2+ stimulated uptake in a concentration-dependent manner. The uptake of the NiS particles was inhibited by trifluoperazine, a calmodulin antagonist, implicating intracellular Ca 2+ in this phagocytosis process. Since the opposite surface charge of crystalline and amorphous NiS has been related to their different phagocytic uptake by cells whose primary function is not phagocytosis (facultative phagocytes), these results show that the culture medium components do not modify the surface charge of these particles in a way that significantly influences their uptake. (Auth.)

  12. Quantum Noether identities for non-local transformations in higher-order derivatives theories

    International Nuclear Information System (INIS)

    Li, Z.P.; Long, Z.W.

    2003-01-01

    Based on the phase-space generating functional of the Green function for a system with a regular/singular higher-order Lagrangian, the quantum canonical Noether identities (NIs) under a local and non-local transformation in phase space have been deduced, respectively. For a singular higher-order Lagrangian, one must use an effective canonical action I eff P in quantum canonical NIs instead of the classical I P in classical canonical NIs. The quantum NIs under a local and non-local transformation in configuration space for a gauge-invariant system with a higher-order Lagrangian have also been derived. The above results hold true whether or not the Jacobian of the transformation is equal to unity or not. It has been pointed out that in certain cases the quantum NIs may be converted to conservation laws at the quantum level. This algorithm to derive the quantum conservation laws is significantly different from the quantum first Noether theorem. The applications of our formulation to the Yang-Mills fields and non-Abelian Chern-Simons (CS) theories with higher-order derivatives are given, and the conserved quantities at the quantum level for local and non-local transformations are found, respectively. (orig.)

  13. Synthesis and biological evaluation of [18F]tetrafluoroborate: a PET imaging agent for thyroid disease and reporter gene imaging of the sodium/iodide symporter

    International Nuclear Information System (INIS)

    Jauregui-Osoro, Maite; Sunassee, Kavitha; Weeks, Amanda J.; Berry, David J.; Paul, Rowena L.; Cleij, Marcel; O'Doherty, Michael J.; Marsden, Paul K.; Szanda, Istvan; Blower, Philip J.; Banga, Jasvinder Paul; Clarke, Susan E.M.; Ballinger, James R.; Cheng, Sheue-Yann

    2010-01-01

    The human sodium/iodide symporter (hNIS) is a well-established target in thyroid disease and reporter gene imaging using gamma emitters 123 I-iodide, 131 I-iodide and 99m Tc-pertechnetate. However, no PET imaging agent is routinely available. The aim of this study was to prepare and evaluate 18 F-labelled tetrafluoroborate ([ 18 F]TFB) for PET imaging of hNIS. [ 18 F]TFB was prepared by isotopic exchange of BF 4 - with [ 18 F]fluoride in hot hydrochloric acid and purified using an alumina column. Its identity, purity and stability in serum were determined by HPLC, thin-layer chromatography (TLC) and mass spectrometry. Its interaction with NIS was assessed in vitro using FRTL-5 rat thyroid cells, with and without stimulation by thyroid-stimulating hormone (TSH), in the presence and absence of perchlorate. Biodistribution and PET imaging studies were performed using BALB/c mice, with and without perchlorate inhibition. [ 18 F]TFB was readily prepared with specific activity of 10 GBq/mg. It showed rapid accumulation in FRTL-5 cells that was stimulated by TSH and inhibited by perchlorate, and rapid specific accumulation in vivo in thyroid (SUV = 72 after 1 h) and stomach that was inhibited 95% by perchlorate. [ 18 F]TFB is an easily prepared PET imaging agent for rodent NIS and should be evaluated for hNIS PET imaging in humans. (orig.)

  14. Nutritional status and nutritional risk in patients with neuroendocrine tumors

    DEFF Research Database (Denmark)

    Borre, Mette; Dam, Gitte Aarøe; Knudsen, Anne Wilkens

    2018-01-01

    BACKGROUND: Malnutrition is frequent among patients with malignancies and associated with impaired function, reduced quality of life and increased mortality. Few data are available in patients with neuroendocrine tumors (NET) on nutritional status, nutritional risk, and nutrition impact symptoms...... (NIS). We aimed to assess nutritional status (NS) and risk, level of function and associations with NIS in NET patients. METHODS: In a cross-sectional study of NET patients, we measured body mass index (BMI) and handgrip strength (HGS) as markers of NS and muscle function assessed by HGS....... The nutritional risk score (NRS) was determined by NRS-2002. NIS was assessed by the eating symptoms questionnaire (ESQ), and disease-related appetite questionnaire (DRAQ). RESULTS: We included 186 patients (51% women), median age 66 years. We observed low BMI (

  15. Reactor instrumentation experience at IPEN-CNEN/SP

    International Nuclear Information System (INIS)

    Soares, A.J.

    1997-01-01

    The Instituto de Pesquisas Energeticas e Nucleares (IPEN) in Sao Paulo started in 1977 development of nuclear instrumentation. In 1982 two groups were established, one responsible for maintenance of electronic equipment and the other, the Nuclear Instrumentation Section (NIS), for new projects, such as a light water moderated critical facility (IPEN/MB-0). The NIS had the responsibility to execute all necessary activities to develop the ''nonconventional'' instrumentation systems: control, protection and radiation monitoring for the IPEN/MB-01 facility. After the commissioning of the critical facility the NIS group started the development of instrumentation systems for a power reactor. As a first step an overall review of the quality assurance programme was implemented. In parallel the development of self powered detectors was carried out. (author). 7 figs

  16. Restaurierung von Seen und Renaturierung von Seeufern

    Science.gov (United States)

    Grüneberg, Björn; Ostendorp, Wolfgang; Leßmann, Dieter; Wauer, Gerlinde; Nixdorf, Brigitte

    Süßwasserseen haben als ökosysteme und Lebensraum für Pflanzen und Tiere eine herausragende Bedeutung für die Artenvielfalt auf der Erde und prägen als Landschaftselemente unsere natürliche Umwelt. Seen fungieren als natürliche Stoffsenken, vor allem für Kohlenstoff und Nährstoffe, aber auch als Senken für in ihren Einzugsgebieten emittierte gelöste und feste Schadstoffe. Darüber hinaus ist Wasser eine wichtige Naturressource. Süßwasserseen stellen in den meisten Regionen der Erde lebenswichtige Quellen für die Versorgung mit Trinkwasser und tierischem Eiweiß (Fischfang) dar. Sie dienen als Wasserspeicher für die landwirtschaftliche und industrielle Nutzung. Auch für Erholungsaktivitäten des Menschen kommt ihnen eine große Bedeutung zu.

  17. Insertion of the human sodium iodide symporter to facilitate deep tissue imaging does not alter oncolytic or replication capability of a novel vaccinia virus

    Directory of Open Access Journals (Sweden)

    Mittra Arjun

    2011-03-01

    Full Text Available Abstract Introduction Oncolytic viruses show promise for treating cancer. However, to assess therapeutic efficacy and potential toxicity, a noninvasive imaging modality is needed. This study aimed to determine if insertion of the human sodium iodide symporter (hNIS cDNA as a marker for non-invasive imaging of virotherapy alters the replication and oncolytic capability of a novel vaccinia virus, GLV-1h153. Methods GLV-1h153 was modified from parental vaccinia virus GLV-1h68 to carry hNIS via homologous recombination. GLV-1h153 was tested against human pancreatic cancer cell line PANC-1 for replication via viral plaque assays and flow cytometry. Expression and transportation of hNIS in infected cells was evaluated using Westernblot and immunofluorescence. Intracellular uptake of radioiodide was assessed using radiouptake assays. Viral cytotoxicity and tumor regression of treated PANC-1tumor xenografts in nude mice was also determined. Finally, tumor radiouptake in xenografts was assessed via positron emission tomography (PET utilizing carrier-free 124I radiotracer. Results GLV-1h153 infected, replicated within, and killed PANC-1 cells as efficiently as GLV-1h68. GLV-1h153 provided dose-dependent levels of hNIS expression in infected cells. Immunofluorescence detected transport of the protein to the cell membrane prior to cell lysis, enhancing hNIS-specific radiouptake (P In vivo, GLV-1h153 was as safe and effective as GLV-1h68 in regressing pancreatic cancer xenografts (P 124I-PET. Conclusion Insertion of the hNIS gene does not hinder replication or oncolytic capability of GLV-1h153, rendering this novel virus a promising new candidate for the noninvasive imaging and tracking of oncolytic viral therapy.

  18. Monitoring of macrophage accumulation in statin-treated atherosclerotic mouse model using sodium iodide symporter imaging system

    International Nuclear Information System (INIS)

    Yoo, Ran Ji; Kim, Min Hwan; Woo, Sang-Keun; Kim, Kwang Il; Lee, Tae Sup; Choi, Yang-Kyu; Kang, Joo Hyun; Lim, Sang Moo; Lee, Yong Jin

    2017-01-01

    Introduction: Macrophages play a key role in atherosclerotic plaque formation in atherosclerosis, but its detailed understanding has poorly investigated until now. Thus, we sought to demonstrate a noninvasive technique for macrophage tracking to atherosclerotic lesions in apolipoprotein E −/− (ApoE −/− ) mice with an imaging system based on sodium iodide symporter (NIS) gene coupled with 99m Tc-single-photon emission computed tomography (SPECT). Methods and results: Macrophage cells (RAW264.7) were stably transduced with retrovirus expressing NIS gene (RAW-NIS). In RAW-NIS cells, uptake of 125 I was higher than the parental cells. [ 18 F]FDG signals in the aorta at 30 weeks on an ApoE −/− mice with high cholesterol diet were higher (1.7 ± 0.12% injected dose (ID)) than those in control group (0.84 ± 0.06% ID). Through 99m Tc-SPECT/computed tomography (CT), in the RAW-NIS cell injected group, the 99m Tc-pertechnetate uptake in aorta was higher than control groups. However, according to atorvastatin treatment, RAW-NIS cell recruitment reduced to the aorta. Area of 99m Tc-pertechnetate uptake was positively correlated with immunostaining results against macrophage antigen (CD68). Cholesterol and low-density lipoprotein levels of atorvastatin-treated group showed lower than those of atorvastatin-untreated group, but did not reach statistical difference. Conclusions: This novel approach to tracking macrophages to atherosclerotic plaques in vivo can be applied for studies of arterosclerotic vascular disease.

  19. Synthesis, Structure, Characterization, and Decomposition of Nickel Dithiocarbamates: Effect of Precursor Structure and Processing Conditions on Solid-State Products

    Science.gov (United States)

    Hepp, Aloysius F.; Kulis, Michael J.; McNatt, Jeremiah S.; Duffy, Norman V.; Hoops, Michael D.; Gorse, Elizabeth; Fanwick, Philip E.; Masnovi, John; Cowen, Jonathan E.; Dominey, Raymond N.

    2016-01-01

    Single-crystal X-ray structures of four nickel dithiocarbamate complexes, the homoleptic mixed-organic bis-dithiocarbamates Ni[S2CN(isopropyl)(benzyl)]2, Ni[S2CN(ethyl)(n-butyl)]2, and Ni[S2CN(phenyl)(benzyl)]2, as well as the heteroleptic mixed-ligand complex NiCl[P(phenyl)3][(S2CN(phenyl)(benzyl)], were determined. Synthetic, spectroscopic, structural, thermal, and sulfide materials studies are discussed in light of prior literature. The spectroscopic results are routine. A slightly distorted square-planar nickel coordination environment was observed for all four complexes. The organic residues adopt conformations to minimize steric interactions. Steric effects also may determine puckering, if any, about the nickel and nitrogen atoms, both of which are planar or nearly so. A trans-influence affects the Ni-S bond distances. Nitrogen atoms interact with the CS2 carbons with a bond order of about 1.5, and the other substituents on nitrogen display transoid conformations. There are no strong intermolecular interactions, consistent with prior observations of the volatility of nickel dithiocarbamate complexes. Thermogravimetric analysis of the homoleptic species under inert atmosphere is consistent with production of 1:1 nickel sulfide phases. Thermolysis of nickel dithiocarbamates under flowing nitrogen produced hexagonal or -NiS as the major phase; thermolysis under flowing forming gas produced millerite (-NiS) at 300 C, godlevskite (Ni9S8) at 325 and 350 C, and heazlewoodite (Ni3S2) at 400 and 450 C. Failure to exclude oxygen results in production of nickel oxide. Nickel sulfide phases produced seem to be primarily influenced by processing conditions, in agreement with prior literature. Nickel dithiocarbamate complexes demonstrate significant promise to serve as single-source precursors to nickel sulfides, a quite interesting family of materials with numerous potential applications.

  20. Comparative analysis of perioperative complications between a multicenter prospective cervical deformity database and the Nationwide Inpatient Sample database.

    Science.gov (United States)

    Passias, Peter G; Horn, Samantha R; Jalai, Cyrus M; Poorman, Gregory; Bono, Olivia J; Ramchandran, Subaraman; Smith, Justin S; Scheer, Justin K; Sciubba, Daniel M; Hamilton, D Kojo; Mundis, Gregory; Oh, Cheongeun; Klineberg, Eric O; Lafage, Virginie; Shaffrey, Christopher I; Ames, Christopher P

    2017-11-01

    Complication rates for adult cervical deformity are poorly characterized given the complexity and heterogeneity of cases. To compare perioperative complication rates following adult cervical deformity corrective surgery between a prospective multicenter database for patients with cervical deformity (PCD) and the Nationwide Inpatient Sample (NIS). Retrospective review of prospective databases. A total of 11,501 adult patients with cervical deformity (11,379 patients from the NIS and 122 patients from the PCD database). Perioperative medical and surgical complications. The NIS was queried (2001-2013) for cervical deformity discharges for patients ≥18 years undergoing cervical fusions using International Classification of Disease, Ninth Revision (ICD-9) coding. Patients ≥18 years from the PCD database (2013-2015) were selected. Equivalent complications were identified and rates were compared. Bonferroni correction (pdatabases. A total of 11,379 patients from the NIS database and 122 patiens from the PCD database were identified. Patients from the PCD database were older (62.49 vs. 55.15, pdatabase. The PCD database had an increased risk of reporting overall complications than the NIS (odds ratio: 2.81, confidence interval: 1.81-4.38). Only device-related complications were greater in the NIS (7.1% vs. 1.1%, p=.007). Patients from the PCD database displayed higher rates of the following complications: peripheral vascular (0.8% vs. 0.1%, p=.001), gastrointestinal (GI) (2.5% vs. 0.2%, pdatabases (p>.004). Based on surgicalapproach, the PCD reported higher GI and neurologic complication rates for combined anterior-posterior procedures (pdatabase revealed higher overall and individual complication rates and higher data granularity. The nationwide database may underestimate complications of patients with adult cervical deformity (ACD) particularly in regard to perioperative surgical details owing to coding and deformity generalizations. The surgeon-maintained database

  1. Nisin Z Production by Lactococcus lactis subsp. cremoris WA2-67 of Aquatic Origin as a Defense Mechanism to Protect Rainbow Trout (Oncorhynchus mykiss, Walbaum) Against Lactococcus garvieae.

    Science.gov (United States)

    Araújo, Carlos; Muñoz-Atienza, Estefanía; Pérez-Sánchez, Tania; Poeta, Patrícia; Igrejas, Gilberto; Hernández, Pablo E; Herranz, Carmen; Ruiz-Zarzuela, Imanol; Cintas, Luis M

    2015-12-01

    Probiotics represent an alternative to chemotherapy and vaccination to control fish diseases, including lactococcosis caused by Lactococcus garvieae. The aims of this study were (i) to determine the in vitro probiotic properties of three bacteriocinogenic Lactococcus lactis subsp. cremoris of aquatic origin, (ii) to evaluate in vivo the ability of L. cremoris WA2-67 to protect rainbow trout (Oncorhynchus mykiss, Walbaum) against infection by L. garvieae, and (iii) to demonstrate the role of nisin Z (NisZ) production as an anti-infective mechanism. The three L. cremoris strains survived in freshwater at 18 °C for 7 days, withstood exposure to pH 3.0 and 10 % (v/v) rainbow trout bile, and showed different cell surface hydrophobicity (37.93-58.52 %). The wild-type NisZ-producer L. cremoris WA2-67 and its non-bacteriocinogenic mutant L. cremoris WA2-67 ∆nisZ were administered orally (10(6) CFU/g) to rainbow trout for 21 days and, subsequently, fish were challenged with L. garvieae CLG4 by the cohabitation method. The fish fed with the bacteriocinogenic strain L. cremoris WA2-67 reduced significantly (p trout against infection with the invasive pathogen L. garvieae and the relevance of NisZ production as an anti-infective mechanism. This is the first report demonstrating the effective in vivo role of LAB bacteriocin (NisZ) production as a mechanism to protect fish against bacterial infection. Our results suggest that the wild-type NisZ-producer strain L. cremoris WA2-67 could be used in fish farming to prevent lactococcosis in rainbow trout.

  2. A luminescent nisin biosensor

    Science.gov (United States)

    Immonen, Nina; Karp, Matti

    2006-02-01

    Nisin is a lantibiotic, an antibacterial peptide produced by certain Lactococcus lactis strains that kills or inhibits the growth of other bacteria. Nisin is widely used as a food preservative, and its long-time use suggests that it can be generally regarded as safe. We have developed a method for determining the amount of nisin in food samples that is based on luminescent biosensor bacteria. Bacterial luciferase operon luxABCDE was inserted into plasmid pNZ8048, and the construct was transformed by electroporation into Lc. lactis strain NZ9800, whose ability to produce nisin has been erased by deletion of the gene nisA. The operon luxABCDE has been modified to be functional in gram-positive bacteria to confer a bioluminescent phenotype without the requirement of adding an exogenous substrate. In the plasmid pNZ8048, the operon was placed under control of the nisin-inducible nisA promoter. The chromosomal nisRK genes of Lc. lactis NZ9800 allow it to sense nisin in the environment and relay this signal via signal transduction proteins NisK and NisR to initiate transcription from nisA promoter. In the case of our sensor bacteria, this leads to production of luciferase and, thus, luminescence that can be directly measured from living bacteria. Luminescence can be detected as early as within minutes of induction. The nisin assay described here provides a detection limit in the sub-picogram level per ml, and a linear area between 1 - 1000 pg/ml. The sensitivity of this assay exceeds the performance of all previously published methods.

  3. In vitro und in vivo Charakterisierung von Endothelvorläuferzellen

    OpenAIRE

    Frauenschuh, Jörg

    2006-01-01

    Die Bedeutung der klinischen Forschung an Stamm- und Vorläuferzellen besonders im Bereich der Geweberegeneration hat im Laufe der letzten Jahre deutlich zugenommen. Stammzellen aus adulten Organismen werden in endodermale, ectodermale und mesodermale Stammzellen, welche endotheliale Vorläuferzellen bilden, unterschieden. Diese Vorläuferzellen wurden in der vorliegenden Arbeit auf Transkriptions- und Translationsebene charakterisiert. Ihre Funktion bei der Angiogenese, speziell der Tumorangiog...

  4. The impact of drought stress on monoterpene biosynthesis in sage (Salvia officinalis): Dehydrins and monoterpene synthases as molecular markers

    OpenAIRE

    Radwan, Alzahraa Mohamed Ahmed

    2014-01-01

    Die Produktqualität von Arzneipflanzen hängt von der Qualität und Quantität der jeweiligen Naturstoffe ab. Eine gezielte Beeinflussung setzt ein umfassendes Wissen über die Biosynthese und deren Regulation voraus. Dabei kommt den komplexen Wechselwirkungen zwischen Stress- und Sekundärstoffwechsel eine besondere Bedeutung zu. Diese Untersuchung zielte darauf ab, exemplarisch die Auswirkungen von Trockenstress auf die Biosynthese und Akkumulation von Monoterpenen in Salbei zu erfassen. Dabei w...

  5. Rechtsextremismus, Prävention und Geschlecht: Vielfalt_Macht_Pädagogik. 2. korrigierte Auflage, Juli 2014

    OpenAIRE

    Debus, Katharina (Ed.); Laumann, Vivien (Ed.)

    2014-01-01

    "(R)echte Kerle" - "Natürliche Weiblichkeit" - "Volksgemeinschaft"Diese Schlagworte machen deutlich, dass extrem rechte Ideologien und Handlungsweisen stark vergeschlechtlicht sind. Für pädagogische Präventionsarbeit ist dies von Bedeutung, da beispielsweise Hinwendung zu und Distanzierung von rechten Lebenswelten mit geschlechtsbezogenen Versprechungen und Anforderungen zu tun haben können. Ergänzend zu anderen Grundsätzen der Präventionsarbeit ist ein Bewusstsein um die Dimension Geschlecht...

  6. Untersuchungen ausgewählter Nierenkrankheiten beim Frettchen (Mustela putorius f. furo L. 1758)

    OpenAIRE

    Riechert, Maren

    2005-01-01

    Um Häufigkeit, Bedeutung und diätetische Ursachen veränderter Nieren beim Frettchen zu erarbeiten, wurden die Nieren von 63 Heimtieren und 120 Labortieren sonographisch untersucht und Fütterungsanalysen durchgeführt. Anatomische Studien an gesunden Nieren wurden für den Vergleich mit den veränderten Nieren angefertigt. Die Untersuchungen zur Anatomie ergaben für das Frettchen Nieren vom einfachen glatten und einwarzigen Typ. Des Weiteren konnten mithilfe von anatomischen ...

  7. CSR Revisited

    DEFF Research Database (Denmark)

    Vetterlein, Antje

    2017-01-01

    Der Begriff der Verantwortung gewinnt zunehmend an Bedeutung in politischen, rechtlichen und ökonomischen Debatten. Verantwortung in Politik ist dabei kein neues Phänomen (Heidbrink 2010), es ist allerdings durchaus kein unkomplizierter Begriff. Die Komplexität wird noch gesteigert, wenn wir von ...... Papier widmet sich diesen und ähnlichen Fragen am Beispiel unternehmerischer Verantwortung, oder corporate social responsibility (CSR)....

  8. Kombinierte Leber- Dünndarmtransplantation

    OpenAIRE

    Thorwarth, Wolf Michael

    2002-01-01

    Nach Transplantation moduliert die Leber nicht nur die Immunantwort des Empfängers gegenüber ihr selbst, sondern übt auch auf mittransplantierte Organe einen protektiven Effekt aus. Dieses Phänomen wurde in der vorliegenden Arbeit an dem hoch immunogenen Dünndarm untersucht. Diese Studie war dabei nicht nur unter immunologischen Gesichtspunkten von Bedeutung. So stellt die simultane Leber- / Dünndarmtransplantation für Patienten, die an einer Leberzirrhose infolge eines Kurzdarmsyndrom leiden...

  9. Aus der Krise lernen – Wirtschaftlichkeit durch Flexibilität und Wandlungsfähigkeit sichern

    OpenAIRE

    Schmidt, Jan

    2012-01-01

    Flexible und wandelbare Fabrikstrukturen sind von hoher Bedeutung, wenn Produktionsstätten in einem turbulenten Umfeld langfristig wettbewerbsfähig bleiben sollen; darin sind sich Forschung und Praxis einig. Während der jüngsten weltweiten Wirtschaftskrise wurden Experten aus dem Airline-Catering-Umfeld befragt, wie Betriebe dieser Branche auf starke Veränderungen vorbereitet sind. Vorgespräche und Analysen des Autors legten die Vermutung nahe, dass diese Dienstleistungsbranche besonderen...

  10. Professionalisierung und Doping im Sport

    OpenAIRE

    Wüterich, Christoph

    2004-01-01

    Der Beitrag untersucht Zusammenhänge zwischen der zunehmenden Professionalisierung des Sports und dem Anstieg von Dopingvergehen. Er zeigt, dass im historischen Vergleich beide Phänomene nicht neu sind, dass sich die Probleme aufgrund der steigenden Bedeutung des Leistungssports aber zugespitzt haben. Ausgehend von einer juristischen und sozioökonomischen Analyse der Anreize zu Doping werden Lösungsvorschläge entwickelt. The author analyzes the interdependencies between a growing commercia...

  11. Einfluss einer vierstündigen Hypoxieexposition (12,5% O 2) auf die Expression von hypoxie-und stressinduzierbaren Proteinen in Zusammenhang mit Antioxidantien

    OpenAIRE

    Höchst, Katrin

    2009-01-01

    Eine adäquate Sauerstoffversorgung des menschlichen Organismus ist eine essentielle Grundvoraussetzung für die Funktion aller Organe und Körpersysteme. In dieser Arbeit beschäftigen wir uns mit der Auswirkung von Hypoxie auf das Immunsystem, was auch im Sport in Bezug auf Höhentraining von Bedeutung ist. Wir untersuchten den Effekt moderater Hypoxie auf die Regulation von verschiedenen Stressantworten des Immunsystems (oxidativer Burst, Phagozytose, Expression der Hitzschockproteine HSP ...

  12. Identifikationsanalyse : Zur Einführung eines neuen Verstehensansatzes in Psychiatrie, Psychotherapie, Literatur- und Sprachwissenschaft

    OpenAIRE

    Herthneck, Kai-Uwe

    2009-01-01

    Hintergrund: Das primäre Problem der Interpretation kommunikativer Akte wie etwa „Symptom-Geschehen“ - zutreffende Bedeutungs-Attribution - ist spätestens seit I. Kant ein schwieriger Aspekt nicht nur der Arzt-Patient-Beziehung. Im vergangenen Jahrhundert findet sich die diesbezügliche Debatte hauptsächlich im Widerstreit verschiedener Schulrichtungen (Psychoanalyse vs. empirische Kognitionswissenschaften, Hermeneutik vs. Konstruktivismus usw.), deren Ausläufer bis in die Gegenwart reichen. S...

  13. NEN UND ANGLIZISMEN IN DER WERBESPRACHE / REMARKS ON THE FUNCTIONS OF LANGUAGE AND THE ANGLICISMS IN ADVERTISING / REMARCI ASUPRA FUNCŢIILOR LIMBAJULUI ŞI ANGLICISMELOR DIN MESAJUL PUBLICITAR

    Directory of Open Access Journals (Sweden)

    Silvia Boncescu

    2015-12-01

    Full Text Available Folgender Bericht stellt die Beeinflussung der Anglizismen auf die Sprachfunktionen in der Werbung dar. Dazu werden die Anglizismen hinsichtlich ihrer Rolle in der Werbesprache herausgestellt. Die Studie zeigt eine häufige Verwendung von fachsprachlichen und gemeinsprachlichen Anglizismen in dem Nachrichtenmagazin Der Spiegel. Die große Bedeutung der Anglizismen für die kontaktherstellende Funktion der Schlagzeilen in der Werbung ergibt sich aus unseren Beispielen und zeigt das hohe Potenzial, Aufmerksamkeit zu erregen.

  14. Untersuchungen zur Radiotoxizität von Tc-99m-markierten Radiotracern in vitro an FRTL-5- und A431-Zellen

    OpenAIRE

    Maucksch, Ute

    2016-01-01

    Einleitung/ Zielstellung Zusätzlich zur Gammastrahlung emittiert 99mTc ca. 5 niederenergetische Auger-Elektronen mit Reichweiten von wenigen Nanometern im Gewebe. Diese haben für die nuklear-medizinische Diagnostik keine Bedeutung. Es wird jedoch über eine therapeutische Nutzung diskutiert, wofür eine Anreicherung der Auger-Elektronen-Emitter in einem strahlensensitiven Zellkompartiment erforderlich ist. Ziel der Arbeit war es, verschiedene [99mTc]Tc-Radiopharmaka hinsichtlich ihres U...

  15. Der vergeschlechtlichte Staat: zum Verhältnis von Freiheit, Geschlecht und Staat bei Jean-Jacques Rousseau

    OpenAIRE

    Nagy, Nicola

    2017-01-01

    "Im Beitrag werden die strategischen und systematischen Funktionen sowie die Bedeutung der von Jean-Jacques Rousseau beschriebenen Geschlechtscharaktere und der darauf bauenden Ordnung des Geschlechterverhältnisses im Rahmen der konkreten Ausgestaltung und Umsetzung seines Modells des Staates sichtbar gemacht. Bemerkenswert ist die Tatsache, dass die Möglichkeitsbedingungen (Gemeinwohlorientierung) von Rousseaus Republik, mit deren Hilfe die Herstellung und der Erhalt der bürgerlichen Freihei...

  16. Analyse und Bewertung von Naturgefahren als Grundlage für ein nachhaltiges Naturgefahrenmanagement in Gebirgssystemen SO-Kasachstans am Beispiel des Ile-Alatau

    OpenAIRE

    Yegorov, Alexandr

    2007-01-01

    Den Fragen der Erarbeitung des Naturgefahrenmanagements in Gebirgsystemen SO-Kasachstans und in den Ländern des Zentralasiens insgesamt wurde bisher keine gebührende Aufmerksamkeit zuteil. Die Naturkatastrophen der letzten Jahrzehnte sowie die Erfahrung mit Maßnahmen zum Schutz des Ile-Alatau vor Naturgefahren haben gezeigt, dass die Lösung dieser Probleme für die weitere nachhaltige Entwicklung dieser Region von erstrangiger Bedeutung ist. In dieser Arbeit wurde vom Autor umfangreiches Ma...

  17. 3D-Druck von Kunststoff-Medizinprodukten

    OpenAIRE

    Polzin, Christian; Seitz, Hermann

    2012-01-01

    Das Additive Manufacturing gewinnt im Bereich der Medizintechnik zur Herstellung von Prototypen bis hin zu Endprodukten zunehmend an Bedeutung. Ein großes Hemmnis stellen allerdings die relativ hohen Fertigungskosten dar. Hier bietet der verstärkte Einsatz der 3D-Drucktechnologie (3D Printing) ein erhebliches Potential zur Reduktion der Kosten. Aus dieser Motivation heraus wurde ein 3D-Druckverfahren zur Herstellung biokompatibler, sterilisierbarer Kunststoffmodelle entwickelt. Beim 3D-Druck-...

  18. Social Class, Gender and the Pace of Academic Life: What Kind of Solution is Slow?

    OpenAIRE

    Heather Mendick

    2014-01-01

    "Ausgangspunkt meines Beitrages ist die wachsende Geschwindigkeit des akademischen Lebens. Wie auch aus den anderen Beiträgen deutlich wird, die diesem Themenschwerpunkt zugehören, gewinnt die Entschleunigungs-Bewegung, die sich der zeitgenössischen Geschwindigkeitsobsession entgegenstellt, auch in der Universität zunehmend an Bedeutung. Mit meinem Artikel schlage ich vor, innezuhalten und genauer anzusehen, welche Lösung Entschleunigung für die aktuelle Krise erbringt. Rückgreifend auf (auto...

  19. Zur Ätiologie und Bekämpfung der Lumpy Jaw Disease bei Kängurus

    OpenAIRE

    Asperger, Michael

    2004-01-01

    In der vorliegenden Arbeit sollten die in der veterinärmedizinischen Literatur bisher diskutierten Ursachen für LJD bei Makropoden hinsichtlich ihrer tatsächlichen Bedeutung abgeklärt und die Eignung einer formalininaktivierten, bestandsspezifischen Adsorbatvakzine zur Prophylaxe von LJD getestet werden. Da LJD eine parodontale Erkrankung darstellt, wurden auch die für Entstehung einer humanen Parodontitis prädisponierenden Faktoren mit in die Untersuchung einbezogen. Es wurden Tupferproben z...

  20. Nationale und transnationale Vernetzung polnischer Städte und Regionen: Auf dem Weg zu einer nachhaltigen Stadt- und Regionalentwicklung

    OpenAIRE

    Dorsch, Pamela

    2003-01-01

    "Die Studie 'Nationale und transnationale Vernetzung polnischer Städte und Regionen - Bedeutung für eine nachhaltige Stadt- und Regionalentwicklung' liefert einen Überblick über die Einbindung polnischer Kommunen und Wojewodschaften in allgemeine und politikfeldspezifische Netzwerke auf nationaler und transnationaler Ebene. Besondere Berücksichtigung findet hierbei die Vernetzung in Fragen von Nachhaltigkeit und des Umweltschutzes. Einführend zeigt die Studie den Prozess zunehmender Dezentral...

  1. Kurzskala zur Erfassung der Unternehmenskultur

    OpenAIRE

    Jöns, Ingela; Hodapp, Markus; Weiss, Katharina

    2005-01-01

    Die Kulturskala zur Erfassung der Unternehmenskultur (KUK) fokussiert auf die Einstufung der Kultur des eigenen Unternehmens und eines anderen Unternehmens durch die Mitarbeiter, wie dies z.B. im Fall von Fusionen von Bedeutung ist. Ihre vier Dimensionen (Strategie, Struktur, Führung und Zusammenarbeit) werden anhand eines bündigen Inventars von 15 Merkmalen erfasst. In einer Untersuchung bei drei Unternehmen der Chemie- und Energiebranche mit einer Gesamtstichprobe von n = 724 konnte gezeigt...

  2. Význam obecného výrazu ve Fregově pojetí

    Czech Academy of Sciences Publication Activity Database

    Vlasáková, Marta

    2013-01-01

    Roč. 5, č. 1 (2013), s. 41-59 ISSN 1804-0969 R&D Projects: GA ČR(CZ) GA13-21076S Institutional support: RVO:67985955 Keywords : the reference of a general term * Frege's Sinn/Bedeutung * the extensional criterion of identity Subject RIV: AA - Philosophy ; Religion http://filosofiednes.ff.uhk.cz/index.php/hen/article/view/115

  3. Die Geschichte des Marburger Universitätsbundes 1920-1957

    OpenAIRE

    Pawelletz, Jörg

    2009-01-01

    Seit dem Ende des Ersten Weltkrieges gibt es Hochschulfördervereine an deutschen Hochschulen und Universitäten, die sich unter verschiedenen Bezeichnungen ab 1917 bildeten und die bis auf wenige Ausnahmen noch bis heute bestehen. Diese frühen Fördervereine verorten sich im Bereich der privaten Wissenschaftsförderung, welche sich in der zweiten Hälfte des 19. Jahrhunderts ausbildete und zunehmend an Bedeutung gewann. Den Höhepunkt ...

  4. Die Raumdarstellung im erzählenden Werk um 1900

    OpenAIRE

    Lu, Xiaoli

    2011-01-01

    In der Literatur existiert eine eigene Welt, die mit Raum und Zeit verbunden ist. Im 19. Jahrhundert gewinnen beide, Raum und Zeit, an Bedeutung als bewusst eingesetzte Gestaltungselemente. Es bilden sich zwei Grundrichtungen heraus, eine mit dem Erzählgeschehen verknüpfte Semantisierung in der Klassik und in der Romantik und eine betonte Fixierung des Geschehens in der realen Welt durch genaue Zeit- und Ortsangaben im Realismus. Die Semantisierung von Raum und Zeit führt zu einer Bedeutungss...

  5. Der Einfluss von sozialer Ungleichheit und kulturellen Unterschieden auf die Wahrnehmung von finanziellen und Arbeitsplatzrisiken: Überlegungen zur Risikogesellschaft

    OpenAIRE

    Abbott, David; Quilgars, Deborah; Jones, Anwen

    2006-01-01

    Der vorliegende Artikel beruht auf Daten einer Studie, die sich mit der Frage beschäftigt, wie verschiedene soziale und kulturelle Gruppen die Risiken von Einkommens- und Arbeitsplatzverlust wahrnehmen und darauf reagieren. Autoren wie LASH, DOUGLAS und LUPTON betonten die Bedeutung von Gruppenzugehörigkeit und sozialen Kategorien für die Strukturierung der Reaktionsweisen auf verschiedene Risikoarten. Sie sprechen daher lieber von Risikokulturen als von der Risikogesellschaft. Trotzdem erken...

  6. Reaktionen auf das Stigma psychischer Erkrankung : Sozialpsychologische Modelle und empirische Befunde

    OpenAIRE

    Rüsch, N

    2010-01-01

    Zusammenfassung. In der jüngeren Forschung zu Stigma und Diskriminierung gewinnt die Frage an Bedeutung, wie Angehörige einer stigmatisierten Minderheit ihre eigene Stigmatisierung wahrnehmen und auf sie reagieren. Aus der sozialpsychologischen Literatur zu anderen Gruppen, etwa ethnischen Minderheiten, liegen gut belegte Modelle zu diesem Thema vor, die bisher jedoch noch kaum auf Menschen mit psychischen Erkrankungen angewandt wurden. Dazu zählen (1) ein Stress-Coping-Modell von St...

  7. Zur Standardisierung der DSH-Prüfungen: Bestandsaufnahme und Perspektiven des Online-Angebotes

    OpenAIRE

    Schneider, Agnieszka

    2010-01-01

    Das Internet ist im 21. Jahrhundert zum wichtigsten Informations- und Kommunikationsmedium geworden und hat auch in der Hochschullandschaft einen festen Platz eingenommen. Das Lernen mit und auf Internetplattformen hat sich im universitären Bereich stark etabliert. Auch die Bedeutung von Online-Prüfungen ist infolge der unter dem Schlagwort "Bologna-Prozess" bekannten Umstrukturierungen stark angestiegen. Da im Bereich der deutschen Sprachprüfung für den Hochschulzugang (DSH) bisher nur wenig...

  8. Refrigeration compressor for the mobile application; Kaeltemittelverdichter fuer den mobilen Einsatz

    Energy Technology Data Exchange (ETDEWEB)

    Hagenlocher, T. [Bock GmbH und Co. Kaeltemaschinenfabrik, Frickenhausen (Germany)

    2000-06-01

    The mobile use of cooling air conditioning systems is increasingly important. Main component of this system is the refrigeration compressor. The special requirement for the compressor as well for the resulting boundary conditions are discussed. (orig.) [German] Der mobile Einsatz von Kaelte- und Klimaanlagen gewinnt zunehmend an Bedeutung. Wichtigste Komponente dieser Anlage ist der Kaeltemittelverdichter. Die speziellen Anforderungen an den Verdichter sowie an die daraus resultierenden Randbedingungen werden dargestellt. (orig.)

  9. Sozialkapital - ein neues OECD-Programm : Bericht über die Tagung 'Measuring Social Capital' Budapest 21.-23. Mai 2003

    OpenAIRE

    Gehmacher, Ernst

    2003-01-01

    'Der Begriff 'Sozialkapital' bezieht sich auf Formen gesellschaftlichen Zusammenhalts, die politischen, sozialen und wirtschaftlichen Nutzen bringen. Unter dem Eindruck, dass sich traditionelle Normen, Vertrauensverhältnisse und Bindungen auflösen und in Zukunft neue soziale Bindungen Bedeutung gewinnen werden, hat die OECD das Programm 'Measuring Social Capital' organisiert: bis 2004 sollen statistische Indikatoren und Survey-Fragen für vergleichende Studien entwickelt werden. Nach einem Übe...

  10. Der Zusammenhang zwischen sportlicher Aktivität und visuell-räumlichen Fähigkeiten

    OpenAIRE

    Pietsch, Stefanie

    2012-01-01

    Thema dieser Arbeit ist es, den Zusammenhang zwischen motorischen bzw. sportlichen Fähigkeiten und visuell-räumlichen Fähigkeiten zu untersuchen. Speziell wird die Bedeutung der konditionellen und koordinativen Fähigkeiten für die mentale Rotationsleistungsfähigkeit, einer klassischen Aufgabe zur Erfassung des visuell-räumlichen Vorstellungsvermögens, untersucht. Die Beteiligung motorischer Prozesse an der mentalen Rotation sowie die Tatsache, dass die Fähigkeit mental zu rotieren durch kogn...

  11. Cold. A fairytale from Orient: Burj al Arab, the new landmark of Dubai; Kaelte. Ein Maerchen aus tausend + einer Nacht: Burj al Arab, das neue Wahrzeichen Dubais

    Energy Technology Data Exchange (ETDEWEB)

    Eleftheriadis, G.

    2002-10-25

    The air conditioning for this hotel plays an important role. To protect coolant water lines safely from dew water and hold down energy losses as low as possible, an elastomere insulating material has been selected. (orig/GL) [German] Der Klimatisierung des Hotels kam im unwirtlichen Wuestenklima natuerlich eine besondere Bedeutung zu. Um die Kuehlwasserleitungen der Klimaanlage sicher vor Tauwasser zu schuetzen und die Energieverluste so gering wie moeglich zu halten, wurde ein elastomerer Daemmstoff gewaehlt. (orig.)

  12. LEXIKALISCHE MITTEL IN DER HOTELWERBUNG

    OpenAIRE

    Blažević, Nevenka

    2003-01-01

    Werbung ist das wichtigste Marketinginstrument in der Hotellerie. Bei jeder Werbekampagne ist die sprachliche Seite von großer Bedeutung. In diesem Beitrag wird die lexikalische Ebene der Prospekttexte analysiert. Es wird auf allgemeine sprachliche Merkmale dieser Textsorte verwiesen. In Hotelprospekten lassen sich zwei Funktionen erkennen: die Informationsfunktion und die Appellfunktion. Die Appellfunktion wird meistens durch Adjektive ausgedrückt. Bei der Auswahl der lexikalischen Mittel...

  13. Politische Inhalte im Internet: Angebot und Nachfrage politischer Inhalte im World Wide Web am Beispiel von Volksabstimmungen in der Schweiz

    OpenAIRE

    Rademacher, Patrick Horst Josef

    2010-01-01

    Welche Bedeutung kommt dem Internet in der Politikvermittlung zu? Dieser Frage geht Patrick Rademacher nach, indem er untersucht, welche Anbieter politische Inhalte im Internet zur Verfügung stellen, wie sie dabei vorgehen und wie die Struktur der Inhalte beschaffen ist. Darüber hinaus analysiert er, inwiefern die online angebotenen Inhalte auf eine Nachfrage durch die Bürger treffen. Im Untersuchungskontext von Volksabstimmungen in der Schweiz hat der Autor hierfür im Jahr 2008 umfangreiche ...

  14. Modelle und Methoden für die Bestandsauslegung in Heijunka-nivellierten Supply Chains

    OpenAIRE

    Veit, Martin B.

    2010-01-01

    In dieser Arbeit werden analytische Bestandsmodelle für die Heijunka-Nivellierung unter Berücksichtigung schwankender Nachfrage- und Produktionsprozesse entwickelt. Dies ist in der Praxis von größerer Bedeutung, als die bisherigen wissenschaftlichen Modelle mit dem Ziel einer möglichst gleichmäßigen Produktionssequenz. Es werden Fragestellungen beantwortet, die bei der Auslegung der Nivellierung in der Industrie immer wieder auftreten, wie z.B. die Auslegung bei saisonalem Nachfrageve...

  15. Blended Learning in der Musiklehrerbildung. Erfahrungen und Perspektiven am Beispiel eines Praxisprojekts

    OpenAIRE

    Lutz, Julia

    2015-01-01

    In der Lehrerbildung zu Beginn des 21. Jahrhunderts wird einem hohen Bezug zum Berufsfeld Schule, phasenübergreifender Zusammenarbeit und lebenslangem Lernen zunehmend Bedeutung geschenkt. Mehr und mehr kommt in Veröffentlichungen und auf den Internetseiten von Lehrerbildungszentren deutscher Universitäten ein umfassendes Verständnis von Lehrerbildung zum Ausdruck, das alle Phasen der Aus- und Fortbildung von Lehrkräften einschließt: Studium, Vorbereitungsdienst („Referendariat“) und Fortbild...

  16. Theoretical Foundations of Contemporary Qualitative Market Research—An Overview and an Integrative Perspective

    OpenAIRE

    Frank, Dirk; Riedl, Peter

    2004-01-01

    Die ökonomische Bedeutung qualitativer Forschung nahm in den vergangenen Jahrzehnten kontinuierlich zu. Als eine der Hauptströmungen in der "Forschungsindustrie" stellt sie nicht nur ein wertvolles Erhebungs- und Analyseinstrumentarium zur Generierung grundlegender Einsichten in das Erleben und Verhalten von Verbrauchern dar, sondern bildet zugleich einen essentiellen Teil der jährlich generierten Umsätze von Forschungsinstituten. Hieraus folgt, dass es für die Anbieter qualitativer Forschung...

  17. Theoretische Grundlagen qualitativer Marktforschung – ein Überblick und eine integrative Perspektive

    OpenAIRE

    Frank, Dirk; Riedl, Peter

    2004-01-01

    Die ökonomische Bedeutung qualitativer Forschung nahm in den vergangenen Jahrzehnten kontinuierlich zu. Als eine der Hauptströmungen in der "Forschungsindustrie" stellt sie nicht nur ein wertvolles Erhebungs- und Analyseinstrumentarium zur Generierung grundlegender Einsichten in das Erleben und Verhalten von Verbrauchern dar, sondern bildet zugleich einen essentiellen Teil der jährlich generierten Umsätze von Forschungsinstituten. Hieraus folgt, dass es für die Anbieter qualitativer Forschung...

  18. Nachsteuer-optimale Anlage- und Finanzierungskonzepte in der Privaten Finanzplanung

    OpenAIRE

    Mederer, Markus Friedrich

    2008-01-01

    In seiner Dissertation untersucht Herr Mederer zentrale Fragestellungen bei Anlage- und Finanzierungsentscheidungen in der Privaten Finanzplanung im Rahmen einer einheitlichen Nachsteuer-Betrachtung. Dies ist insofern von Bedeutung, da - wie einleitend aufzeigt wird - einerseits kundenseitig eine große Notwendigkeit für die Private Finanzplanung über alle Bevölkerungs- und Einkommensschichten hinweg existiert, nicht zuletzt aufgrund der immer komplexer werdenden steuerlichen Regelungen. Ander...

  19. Internationale Markteintrittsstrategien mittelgroßer Industrieunternehmen (MU) : am Beispiel deutscher Unternehmen in der VR China

    OpenAIRE

    Fu, Guichen

    2005-01-01

    Aufgrund der Globalisierung der Wirtschaft und der zunehmenden Bedeutung des chinesischen Marktes sind immer mehr Unternehmen mit Fragestellungen, welche die Wahl einer optimalen Markteintrittsstrategie für China betreffen, konfrontiert. Mit der vorliegenden Arbeit wurde der Versuch unternommen, auf Basis einer Kombination von Transaktionskostentheorie, Ressourcenansatz und standorttheoretischen Ansätzen ein Erklärungsmodell zur Entscheidungsunterstützung bei der Wahl der Markteintrittsstrate...

  20. Do We Need a New Approach to Library and Information Science?

    OpenAIRE

    Audunson, Ragnar Andreas

    2018-01-01

    Der vorliegende Beitrag analysiert den durch die Digitalisierung bedingten Druck auf das Bibliothekswesen und die Bibliotheks- und Informationswissenschaft sowie auf die zunehmende Bedeutung der Bibliotheken als Begegnungsorte und -arenen für die Öffentlichkeit. Beide Entwicklungstendenzen stellen die Notwendigkeit von Bibliothekaren als Vermittler zwischen Nutzern und Informationsquellen in Frage. Das Navigieren und Suchen nach Informationen in einer digitalen Welt, wenn die Welt selbst eine...

  1. Recycling of plastic materials collected by `Duales System Deutschland (DSD)`; Werkstoffliches Recycling von Kunststoffen aus DSD-Sammlungen

    Energy Technology Data Exchange (ETDEWEB)

    Baumgaertner, D. [Lech-Elektrizitaetswerke AG, Augsburg (Germany); Heinz, H. [Lech-Elektrizitaetswerke AG, Augsburg (Germany); Hiller, W. [Lech-Elektrizitaetswerke AG, Augsburg (Germany)

    1996-01-01

    The article deals with the importance, problems and technology of plastics recycling. It gives an overview of the specific demands of plastics recyclates, the necessary process technology, and the characteristic values of materials. (orig.) [Deutsch] Es wird die Bedeutung, die Problematik und Technik des werkstofflichen Recyclings von Kunststoffen dargestellt. Dabei sind sowohl die spezifischen Anforderungen des Einsatzstoffes als Recyclingmaterial, die notwendige Verfahrenstechnik als auch die werkstofflichen Kennwerte in einer Uebersicht dargestellt. (orig.)

  2. Politische Graffiti als Instrument der Sozialraumforschung in Konfliktregionen - das Beispiel Baskenland

    OpenAIRE

    Stelzel, Katharina

    2014-01-01

    Die zwischen Sozialpädagogik und Kriminologie interdisziplinär angelegte Arbeit beleuchtet im empirischen Verfahren und diesbezüglich erstmals in deutscher Sprache die Charakteristik baskischer politischer Graffiti und ihre Rolle in einer konfliktgeladenen Gesellschaft. In ihrer Ausgangsfrage lotet die vorliegende Arbeit die Bedeutung des Kommunikationsmediums Graffiti als Informationsquelle für die Sozialraumanalyse in Konfliktregionen aus. Als Grundlage für weitere Überlegungen und als V...

  3. Screening und Quantifizierung organischer Spurenstoffe mittels UPLC-HRMS:Entwicklung von Methoden und Anwendung zur Unterscheidung historischer und aktueller Spurenstoffe in einem ehemaligen Rieselfeld

    OpenAIRE

    Wode, Florian

    2014-01-01

    Aufgrund zunehmender Wasserknappheit gewinnt die Nutzung von gereinigtem Abwasser (Klarwasser), bezeichnet als Water Reuse, weltweit an Bedeutung. Neben herkömmlichen chemischen und mikrobiologischen Parametern spielen organische Spurenstoffe zunehmend eine Rolle bei der Beurteilung der Wasserqualität, die über mögliche Nutzungsformen entscheidet. In dieser Arbeit wurde die Spurenstoffbelastung in Grund- und Oberflächenwasser eines ehemaligen Rieselfeldgebietes untersucht, in dem seit 2005 Kl...

  4. Der Wandel der Erwerbsformen und der Beitrag der Hartz-Reformen: Berlin und die Bundesrepublik Deutschland im Vergleich

    OpenAIRE

    Oschmiansky, Heidi

    2007-01-01

    "Seit den 1980er Jahren wird der Wandel der Erwerbsformen in der Bundesrepublik Deutschland immer stärker sichtbar. Während die sozial abgesicherte, abhängige und unbefristete Vollzeiterwerbsform - das sog. 'Normalarbeitsverhältnis' - seither leicht an Bedeutung verloren hat, zeigen sich bei den übrigen Erwerbsformen zum Teil hohe Zuwächse und eine zunehmende Differenzierung. Der vorliegende Beitrag untersucht den Wandel der Erwerbsformen zwischen 1985 und 2005 auf Basis von Mikrozensus-Daten...

  5. Kontexte qualitativer Sozialforschung: Arts-Based Research, Mixed Methods und Emergent Methods

    OpenAIRE

    Schreier, Margrit

    2017-01-01

    In dem vorliegenden Beitrag werden drei Kontexte qualitativer Sozialforschung genauer dargestellt, die in den vergangenen Jahren zunehmend an Bedeutung gewonnen haben: Arts-Based Research, Mixed Methods und Emergent Methods. Es werden verschiedene Ansätze und Varianten von Arts-Informed und Arts-Based Research genauer beschrieben, und es wird argumentiert, dass Arts-Based Research eine eigenständige Forschungstradition darstellt, die der qualitativen Sozialforschung wichtige Impulse geben kan...

  6. Ganzheitlich prozessorientierte Entscheidungsunterstützung am Beispiel der Automobillackierung : Ein Beitrag zum industriellen Stoffstrommanagement

    OpenAIRE

    Rosenau-Tornow, Dirk

    2005-01-01

    Im Rahmen der sich verknappenden Ressourcen, der Anforderungen durch die Umweltgesetzgebung sowie des Gedankens einer nachhaltigen Entwicklung wird es für Unternehmen zunehmend wichtiger, den Aufwand für die Herstellung von Gütern und Dienstleistungen effizienter zu gestalten. Dabei gewinnt eine ganzheitliche Sichtweise unternehmerischer Entscheidung im Sinne von Technik, Ökonomie und Ökologie an Bedeutung, die eine Entkopplung von Wirtschaftswachstum und Ressourcenverbrauch bewirkt. Für betr...

  7. Gewerbsmässigkeit im schweizerischen Luftrecht

    OpenAIRE

    Müller, Roland

    2005-01-01

    Der Begriff der Gewerbsmässigkeit hat im schweizerischen Luftrecht eine grosse Bedeutung. Werden gewerbsmässige Flüge ohne die entsprechenden Bewilligungen und Voraussetzungen durchgeführt, so resultieren gravierende zivilrechtliche, strafrechtliche und administrative Konsequenzen. In den massgebenden internationalen Luftfahrtabkommen findet sich keine Definition der Gewerbsmässigkeit, dies wird den einzelnen Staaten überlassen. Nur in den Joint Aviation Requirements und in der EU-Zollver...

  8. Wie Geschwister sich in ihrer musikalischen Entwicklung beeinflussen. Ergebnisse einer Erhebung mit offenem Fragebogen

    OpenAIRE

    Olbertz, Franziska

    2012-01-01

    Die Rolle der Geschwister in der musikalischen Entwicklung sollte anhand empirischer Daten fassbar gemacht und damit eine Forschungslücke der musikalischen Entwicklungspsychologie geschlossen werden. Dazu wurden in der aktuellen Studie zunächst die Formen der musikalischen Beeinflussung unter Geschwistern qualitativ erhoben und kategorisiert. Einfache quantitative Analysen desselben Materials sollten auch Hypothesen über die Bedeutung einiger Variablen ermöglichen, wie z. B. des Altersabstand...

  9. Polnische qualitative Soziologie: Entwicklung und Hauptthemen

    OpenAIRE

    Konecki, Krzysztof T.; Kacperczyk, Anna M.; Marciniak, Lukasz T.

    2005-01-01

    In dem vorliegenden Beitrag wird die Entwicklung der qualitativen Soziologie in Polen rekonstruiert, indem deren wesentliche intellektuelle Wurzeln und einige Hauptthemen der polnischen Soziologie vorgestellt werden. Romantizismus und die induktive Methode sind essenzielle Elemente für die Entwicklung der Disziplin in Polen gewesen und Charakteristika ihrer Besonderheit. Die Bedeutung von Florian ZNANIECKI für die Entstehung der polnischen qualitativen Soziologie wird gewürdigt. URN: urn:n...

  10. Polish Qualitative Sociology. The General Features and Development

    OpenAIRE

    Konecki, Krzysztof T.; Kacperczyk, Anna M.; Marciniak, Lukasz T.

    2005-01-01

    In dem vorliegenden Beitrag wird die Entwicklung der qualitativen Soziologie in Polen rekonstruiert, indem deren wesentliche intellektuelle Wurzeln und einige Hauptthemen der polnischen Soziologie vorgestellt werden. Romantizismus und die induktive Methode sind essenzielle Elemente für die Entwicklung der Disziplin in Polen gewesen und Charakteristika ihrer Besonderheit. Die Bedeutung von Florian ZNANIECKI für die Entstehung der polnischen qualitativen Soziologie wird gewürdigt. The articl...

  11. Verknüpfung von DQ-Indikatoren mit KPIs und Auswirkungen auf das Return on Investment

    Science.gov (United States)

    Block, Frank

    Häufig ist nicht klar, welche Beziehungen zwischen Datenqualitätsindikatoren (DQI, Definition folgt weiter unten) und Key Performance Indicators (KPI, s. Abschnitt 1.3 für weitere Details) eines Unternehmens oder einer Organisation bestehen. Dies ist insbesondere deshalb von Bedeutung, da die Kenntnis dieser Beziehungen maßgeblich die Ausprägung eines Datenqualitätsprojekts beeinflusst.

  12. Competitive Intelligence : Aufbau einer Informationsbasis und Entscheidungssystematik zur Definition strategischer Zielmärkte

    OpenAIRE

    Maffenbeier, Sina

    2010-01-01

    Im Rahmen der Globalisierung und des daraus resultierenden Wettbewerbs ist es für ein Unternehmen von zentraler Bedeutung, Wissen über die Wettbewerbssituation zu erhalten. Nicht nur zur Erschließung neuer Märkte, sondern auch zur Sicherung der Unternehmensexistenz ist eine Wettbewerbsanalyse unabdingbar. Konkurrenz- bzw. Wettbewerbsforschung wird überwiegend als „Competitive Intelligence“ bezeichnet. In diesem Sinne beschäftigt sich die vorliegende Bachelorarbeit mit einem Bereich von Compet...

  13. Smokers who report smoking but do not consider themselves smokers: a phenomenon in need of further attention.

    Science.gov (United States)

    Leas, Eric C; Zablocki, Rong W; Edland, Steven D; Al-Delaimy, Wael K

    2015-07-01

    Heightened stigma surrounding the action of smoking may decrease the likelihood that individuals who engage in smoking identify with the label 'smoker'. Non-identifying smokers (NIS) may undermine accurate smoking prevalence estimates and can be overlooked by tobacco control efforts. We sought to characterise NIS in a cross-sectional study using a sample representative of the population of adults (>18 years) in California who reported smoking at least 100 cigarettes in their lifetime, smoking at least some days and at least once in the last 30 days (n=1698). Individuals were considered NIS if they met the above criteria and answered 'no' when asked if they 'considered themselves a smoker'. We estimate that 395 928 (SD=54 126) NIS were living in California in 2011 (a prevalence of 12.3% of all smokers in California). The odds of being NIS were higher among non-daily smokers who were previously daily smokers (adjusted OR (AOR)=7.63, 95% CI 2.67 to 21.8) or were never previously daily smokers (AOR=7.14, CI 2.78 to 18.3) compared with daily smokers. The odds of being an NIS were also higher among those who did not believe they were addicted to cigarettes (AOR=3.84, CI 1.68 to 9.22), were older than 65 years (vs less than 45 years) (AOR=3.35, CI 1.16 to 9.75) or were from ethnic minorities including Black and Asian (vs non-Hispanic white) (AOR=3.16, CI 1.19 to 8.49). Smoking surveillance should restructure selection criteria to more accurately account for NIS in areas with high stigma toward smokers. Targeted interventions may be needed for NIS including educating healthcare providers to enquire more deeply into smoking habits. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  14. Materials and process engineering projects for the Sandia National Laboratories/Newly Independent States Industrial Partnering Program. Volume 2

    International Nuclear Information System (INIS)

    Zanner, F.J.; Moffatt, W.C.

    1995-07-01

    In July, 1994, a team of materials specialists from Sandia and US. Industry traveled to Russia and the Ukraine to select and fund projects in materials and process technology in support of the Newly Independent States/Industrial Partnering Program (NIS/IPP). All of the projects are collaborations with scientists and Engineers at NIS Institutes. Each project is scheduled to last one year, and the deliverables are formatted to supply US. Industry with information which will enable rational decisions to be made regarding the commercial value of these technologies. This work is an unedited interim compilation of the deliverables received to date

  15. Materials and process engineering projects for the Sandia National Laboratories/Newly Independent States Industrial Partnering Program. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Zanner, F.J.; Moffatt, W.C.

    1995-07-01

    In July, 1994, a team of materials specialists from Sandia and U S Industry traveled to Russia and the Ukraine to select and fund projects in materials and process technology in support of the Newly Independent States/Industrial Partnering Program (NIS/IPP). All of the projects are collaborations with scientists and Engineers at NIS Institutes. Each project is scheduled to last one year, and the deliverables are formatted to supply US Industry with information which will enable rational decisions to be made regarding the commercial value of these technologies. This work is an unedited interim compilation of the deliverables received to date.

  16. Serial Derotational Casting in Idiopathic and Non-Idiopathic Progressive Early-Onset Scoliosis.

    Science.gov (United States)

    Gussous, Yazeed M; Tarima, Sergey; Zhao, Shi; Khan, Safdar; Caudill, Angela; Sturm, Peter; Hammerberg, Kim W

    2015-05-01

    Serial derotational casting has been used as a definitive treatment or as delaying strategy in progressive idiopathic (IS) and non-idiopathic (NIS) early-onset scoliosis (EOS). Retrospective chart and radiographic review of patients who underwent serial casting for progressive EOS between 2005 and 2012 at a single institution. A total of 74 consecutive patients entered serial cast treatment. Twenty-eight were currently being casted, 30 completed cast treatment and were converted to thoracolumbosacral orthosis (TLSO), 9 were treated surgically, 6 were lost to follow-up, and 1 had no further treatment. The researchers diagnosed IS in 41 patients; 33 had NIS. At presentation the IS group had an average Cobb angle (CA) of 49° and a rib vertebral angle difference (RVAD) of 37°. The NIS group had a CA of 51° (p = .69) and RVAD of 37° (p = .94). In patients currently being casted, 19 IS patients had a decreased CA, from 47° to 27°. The 9 NIS patients had a decreased CA, from 62° to 57° (p = .0002). Cobb angle improvement was significantly better in IS (p = .0005). In the TLSO group the 17 IS patients had a decreased average CA, from 46° to 18°, after serial casting and the 13 NIS patients decreased CA from 42° to 32°. Patients with IS had better improvement in CA than the NIS group (p Casting initiated before age 2 years yielded better curve correction for IS (p casting than NIS patients. Casting in IS patients before age 24 months yielded better curve correction. Patients who required surgery had a higher age and Cobb angle at presentation than those who transitioned to a TLSO. The surgical group was observed for a similar duration of time and there was no significant statistical difference. Although RVAD is a predictor of progression in infantile IS, it did not show a predictive value in the response to casting of either the IS or NIS groups. Copyright © 2015 Scoliosis Research Society. Published by Elsevier Inc. All rights reserved.

  17. A Trial of Nursing Cost Accounting using Nursing Practice Data on a Hospital Information System.

    Science.gov (United States)

    Miyahira, Akiko; Tada, Kazuko; Ishima, Masatoshi; Nagao, Hidenori; Miyamoto, Tadashi; Nakagawa, Yoshiaki; Takemura, Tadamasa

    2015-01-01

    Hospital administration is very important and many hospitals carry out activity-based costing under comprehensive medicine. However, nursing cost is unclear, because nursing practice is expanding both quantitatively and qualitatively and it is difficult to grasp all nursing practices, and nursing cost is calculated in many cases comprehensively. On the other hand, a nursing information system (NIS) is implemented in many hospitals in Japan and we are beginning to get nursing practical data. In this paper, we propose a nursing cost accounting model and we simulate a cost by nursing contribution using NIS data.

  18. Feasibility of sodium/iodide symporter gene as a new imaging reporter gene: comparison with HSV1-tk

    International Nuclear Information System (INIS)

    Shin, Jae Hoon; Chung, June-Key; Lee, Yong Jin; Kim, Kwang Il; Kang, Joo Hyun; Jeong, Jae Min; Lee, Dong Soo; Kim, Chul Woo; Lee, Myung Chul

    2004-01-01

    Positron emission tomography (PET) imaging reporter genes, such as HSV1-tk and D 2 receptor genes, make it possible to visualise gene expression non-invasively and repetitively in vivo. However, these systems require the synthesis of complicated substrates and the availability of expensive PET equipment. Expression of the sodium/iodide symporter (NIS) gene can be easily monitored with radioiodines and technetium-99m using a gamma camera. To evaluate the possibility of using NIS as an imaging reporter gene, we compared its characteristics with those of the conventional HSV1-tk gene. The CM cell line was made by transfecting the HSV1-tk gene into CT-26 (mouse colon carcinoma cell line). The CTN and CMN cell lines were then made by transfecting the NIS gene into CT-26 and CM. We measured the uptake of iodine-125 iodovinyldeoxyuridine ([ 125 I]IVDU) and 125 I to evaluate the expression of the HSV1-tk and NIS genes, respectively. Each cell line was injected into four flank sites in Balb/c mice. The biodistribution study was performed after intravenously injecting [ 125 I]IVDU and 131 I, and 131 I scintigraphy was performed for the evaluation of NIS expression. In vitro studies indicated that CTN and CMN had 40- to 79-fold and 150- to 256-fold higher uptake of 125 I than CT-26 and CM, respectively. Furthermore, CM and CMN showed 57- to 69-fold higher uptake of [ 125 I]IVDU than CT-26 and CTN. NIS gene expression and 125 I accumulation were found to be directly correlated (R 2 =0.923), as were HSV1-tk gene expression and [ 125 I]IVDU accumulation (R 2 =0.956). Calculated signal per unit NIS and HSV1-tk mRNA expression was 23,240±3,755 cpm and 34,039±5,346 cpm, respectively. In vivo study indicated that CTN and CMN had 2.3- and 5.8-fold higher uptake of 131 I than CT-26 and CM, and 1.8- and 3.5-fold higher uptake of [ 125 I]IVDU than CT-26 and CTN. Scintigraphy using 131 I easily visualised CTN and CMN tumours. In conclusion, the NIS gene may be viewed as an imaging

  19. Quantitative assessment of Aluminium cast Alloys` structural parameters to optimize ITS properties

    Directory of Open Access Journals (Sweden)

    L. Kuchariková

    2017-01-01

    Full Text Available The present work deals with evaluation of eutectic Si (its shape, size, and distribution, dendrite cell size and dendrite arm spacing in aluminium cast alloys which were cast into different moulds (sand and metallic. Structural parameters were evaluated using NIS-Elements image analyser software. This software is imaging analysis software for the evaluation, capture, archiving and automated measurement of structural parameters. The control of structural parameters by NIS Elements shows that optimum mechanical properties of aluminium cast alloys strongly depend on the distribution, morphology, size of eute ctic Si and matrix parameters.

  20. Materials and process engineering projects for the Sandia National Laboratories/Newly Independent States Industrial Partnering Program. Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    Zanner, F.J.; Moffatt, W.C.

    1995-07-01

    In July, 1994, a team of materials specialists from Sandia and US. Industry traveled to Russia and the Ukraine to select and fund projects in materials and process technology in support of the Newly Independent States/Industrial Partnering Program (NIS/IPP). All of the projects are collaborations with scientists and Engineers at NIS Institutes. Each project is scheduled to last one year, and the deliverables are formatted to supply US. Industry with information which will enable rational decisions to be made regarding the commercial value of these technologies. This work is an unedited interim compilation of the deliverables received to date.

  1. The Contracting Officer’s Representative.

    Science.gov (United States)

    1983-05-01

    Peters ’ procedure of examining the "totality of circumstances" probably best describes what is going on. -In W. Southard Jones 17 4 no specific...8217 "" ’. ". e-- -. "-" " ’ ., incduae nis duly appointea successor or nis Aut.nor4 zec Representat ve, ’ and :ne ’ogic of C. S eornerZ v. Jr-e c States. 20...38,831. 166. Id. 167. Supra, note 94. 168. Id., at 44,871. 169. Id. 170. Franklin W. Peters and Assocs., IBCA No. 762-1-69, 71-1 BCA 8615 (1971). 171. Id

  2. Gazprom skooris topeltpunktid / Lauri Linnamäe

    Index Scriptorium Estoniae

    Linnamäe, Lauri

    2008-01-01

    Gazprom ja Austria energiakompanii OMV sõlmisid lepingu, mille järgi läheb Venemaast sõltumatu gaasijuhtme lõpp-punktiks kavandatud Nabucco gaasijuhtme Baumgarteni gaasijaotuskeskus Gazpromi kontrolli alla. Gazprom kindlustas samal ajal sõlmitud lepinguga juhipositsiooni ka Serbia riiklikus naftakompaniis NIS

  3. Classification systems in nursing : Formalizing nursing knowledge and implications for nursing information systems

    NARCIS (Netherlands)

    Goossen, WTF; Epping, PJMM; Abraham, IL

    The development of nursing information systems (NIS) is often hampered by the fact that nursing lacks a unified nursing terminology and classification system. Currently there exist various initiatives in this area. We address the question as to how current initiatives in the development of nursing

  4. Preparation of NiS/ZnIn2S4 as a superior photocatalyst for hydrogen evolution under visible light irradiation

    Directory of Open Access Journals (Sweden)

    Liang Wei

    2013-12-01

    Full Text Available In this study, NiS/ZnIn2S4 nanocomposites were successfully prepared via a facile two-step hydrothermal process. The as-prepared samples were characterized by X-ray diffraction (XRD, X-ray photoelectron spectroscopy (XPS, transmission electron microscopy (TEM and high-resolution transmission electron microscopy (HRTEM. Their photocatalytic performance for hydrogen evolution under visible light irradiation was also investigated. It was found that the photocatalytic hydrogen evolution activity over hexagonal ZnIn2S4 can be significantly increased by loading NiS as a co-catalyst. The formation of a good junction between ZnIn2S4 and NiS via the two step hydrothermal processes is beneficial for the directional migration of the photo-excited electrons from ZnIn2S4 to NiS. The highest photocatalytic hydrogen evolution rate (104.7 μmol/h, which is even higher than that over Pt/ZnIn2S4 nanocomposite (77.8 μmol/h, was observed over an optimum NiS loading amount of 0.5 wt %. This work demonstrates a high potential of the developing of environmental friendly, cheap noble-metal-free co-catalyst for semiconductor-based photocatalytic hydrogen evolution.

  5. Neurofibromatosis Associated With Hyper Parathyroidism

    Directory of Open Access Journals (Sweden)

    Agha Hosseini F

    1999-12-01

    Full Text Available A case involving the rare occurance of hyperparathyroidism in association with neurofibromatosis"nis reported."nRadiographic findings revealed multiple radiolucency which diagnosed as giant cell lesions. Also, high levels"nof PTH and alkalan phosphatase were found from repeated measurements of the serum."nNeurofibromatosis associated with hyperparathyroidism diagnosed in this case report.

  6. Psychobiological characteristics of dissociative identity disorder: a symptom provocation study.

    Science.gov (United States)

    Reinders, A A T Simone; Nijenhuis, Ellert R S; Quak, Jacqueline; Korf, Jakob; Haaksma, Jaap; Paans, Anne M J; Willemsen, Antoon T M; den Boer, Johan A

    2006-10-01

    Dissociative identity disorder (DID) patients function as two or more identities or dissociative identity states (DIS), categorized as 'neutral identity states' (NIS) and 'traumatic identity states' (TIS). NIS inhibit access to traumatic memories thereby enabling daily life functioning. TIS have access and responses to these memories. We tested whether these DIS show different psychobiological reactions to trauma-related memory. A symptom provocation paradigm with 11 DID patients was used in a two-by-two factorial design setting. Both NIS and TIS were exposed to a neutral and a trauma-related memory script. Three psychobiological parameters were tested: subjective ratings (emotional and sensori-motor), cardiovascular responses (heart rate, blood pressure, heart rate variability) and regional cerebral blood flow as determined with H(2)(15)O positron emission tomography. Psychobiological differences were found for the different DIS. Subjective and cardiovascular reactions revealed significant main and interactions effects. Regional cerebral blood flow data revealed different neural networks to be associated with different processing of the neutral and trauma-related memory script by NIS and TIS. Patients with DID encompass at least two different DIS. These identities involve different subjective reactions, cardiovascular responses and cerebral activation patterns to a trauma-related memory script.

  7. Pressures and Resistance to the Introduction of Skills in Business Administration and Accounting Education in Spain: A New Institutional Theory Analysis

    Science.gov (United States)

    Gonzalez, Jose Maria Gonzalez; Montano, Jose Arquero; Hassall, Trevor

    2009-01-01

    Teachers, students and professionals have confirmed the need to introduce skills into business administration and accounting education in Spain. However, this change has not taken place at any desirable level. This paper uses the New Institutional Sociology (NIS) to analyse the pressures to introduce the policy that consists of the incorporation…

  8. Institutional overlap as a basis for international business

    NARCIS (Netherlands)

    Maseland, Robbert; Verbeke, Alain; Puck, Jonas; Tulder, Rob

    2017-01-01

    This chapter investigates the theoretical support for the distance metaphor that is widely used to capture the effects of institutional diversity in international business (IB) and management studies. It argues that neither new institutional economics (NIE) nor in neo-institutional sociology (NIS)

  9. Algab "Valgete ööde" festival

    Index Scriptorium Estoniae

    2006-01-01

    18. juunil toimub Endla teatri küünis nüüdistantsule ja -teatrile keskenduva "Valgete ööde" festivali esimene etendus - saab näha tantsutruppi Company B. Valiente. Esitatakse tantsulavastus "Body Business" (koreograafid Marcelino Martin Valiente ja Gunhild Bjornsgaard)

  10. Neonicotinoid insecticides in pollen, honey and adult bees in colonies of the European honey bee (Apis mellifera L.) in Egypt.

    Science.gov (United States)

    Codling, Garry; Naggar, Yahya Al; Giesy, John P; Robertson, Albert J

    2018-03-01

    Honeybee losses have been attributed to multiple stressors and factors including the neonicotinoid insecticides (NIs). Much of the study of hive contamination has been focused upon temperate regions such as Europe, Canada and the United States. This study looks for the first time at honey, pollen and bees collected from across the Nile Delta in Egypt in both the spring and summer planting season of 2013. There is limited information upon the frequency of use of NIs in Egypt but the ratio of positive identification and concentrations of NIs are comparable to other regions. Metabolites of NIs were also monitored but given the low detection frequency, no link between matrices was possible in the study. Using a simple hazard assessment based upon published LD 50 values for individual neonicotinoids upon the foraging and brood workers it was found that there was a potential risk to brood workers if the lowest reported LD 50 was compared to the sum of the maximum NI concentrations. For non-lethal exposure there was significant risk at the worst case to brood bees but actual exposure effects are dependant upon the genetics and conditions of the Egyptian honeybee subspecies that remain to be determined.

  11. Child Protection and Justice Systems Processing of Serious Child Abuse and Neglect Cases

    Science.gov (United States)

    Sedlak, Andrea J.; Schultz, Dana; Wells, Susan J.; Lyons, Peter; Doueck, Howard J.; Gragg, Frances

    2006-01-01

    Objective: The aim of this study was to examine the trajectory of cases through four systems: child protection, law enforcement, the dependency courts, and the criminal courts. Method: This study focused on a county selected from a 41-county telephone survey conducted for the National Incidence Study of Child Abuse and Neglect (NIS-3). For this…

  12. Author Details

    African Journals Online (AJOL)

    Optical characteristics of crystalline antimony sulphide (Sb2S3) thin film. Abstract · Vol 17 (2010) - Articles Study of Optical, Solid State and Structural Properties of Nickel Sulphide (NiS) Thin Films Deposited using Solution Growth Technique. Abstract · Vol 17 (2010) - Articles Determination of the Spatial Variation of the Hole ...

  13. Author Details

    African Journals Online (AJOL)

    Optical characteristics of crystalline antimony sulphide (Sb2S3) thin film. Abstract · Vol 17 (2010) - Articles Study of Optical, Solid State and Structural Properties of Nickel Sulphide (NiS) Thin Films Deposited using Solution Growth Technique. Abstract. ISSN: 1116-4336. AJOL African Journals Online. HOW TO USE AJOL.

  14. SULFIDE MINERALS IN SEDIMENTS

    Science.gov (United States)

    The formation processes of metal sulfides in sediments, especially iron sulfides, have been the subjects of intense scientific research because of linkages to the global biogeochemical cycles of iron, sulfur, carbon, and oxygen. Transition metal sulfides (e.g., NiS, CuS, ZnS, Cd...

  15. High-Throughput Screening and Quantitative Chemical Ranking for Sodium-Iodide Symporter Inhibitors in ToxCast Phase I Chemical Library.

    Science.gov (United States)

    Wang, Jun; Hallinger, Daniel R; Murr, Ashley S; Buckalew, Angela R; Simmons, Steven O; Laws, Susan C; Stoker, Tammy E

    2018-05-01

    Thyroid uptake of iodide via the sodium-iodide symporter (NIS) is the first step in the biosynthesis of thyroid hormones that are critical for health and development in humans and wildlife. Despite having long been a known target of endocrine disrupting chemicals such as perchlorate, information regarding NIS inhibition activity is still unavailable for the vast majority of environmental chemicals. This study applied a previously validated high-throughput approach to screen for NIS inhibitors in the ToxCast phase I library, representing 293 important environmental chemicals. Here 310 blinded samples were screened in a tiered-approach using an initial single-concentration (100 μM) radioactive-iodide uptake (RAIU) assay, followed by 169 samples further evaluated in multi-concentration (0.001 μM-100 μM) testing in parallel RAIU and cell viability assays. A novel chemical ranking system that incorporates multi-concentration RAIU and cytotoxicity responses was also developed as a standardized method for chemical prioritization in current and future screenings. Representative chemical responses and thyroid effects of high-ranking chemicals are further discussed. This study significantly expands current knowledge of NIS inhibition potential in environmental chemicals and provides critical support to U.S. EPA's Endocrine Disruptor Screening Program (EDSP) initiative to expand coverage of thyroid molecular targets, as well as the development of thyroid adverse outcome pathways (AOPs).

  16. Studies on isolation and partial purification of lysozyme from egg ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-01-05

    Jan 5, 2009 ... nine species of lovebirds, and many different colour var- ieties. Their scientific name Agapornis comes from the. Greek Agapa meaning, “Love” and ornis meaning “bird”. This paper describes the isolation, partial purification and determination of molecular weight of lysozyme of Agapor- nis sp. egg white.

  17. Nosocomial Serratia marcescens infections associated with extrinsic contamination of a liquid nonmedicated soap.

    Science.gov (United States)

    Sartor, C; Jacomo, V; Duvivier, C; Tissot-Dupont, H; Sambuc, R; Drancourt, M

    2000-03-01

    To determine the role of nonmedicated soap as a source of Serratia marcescens nosocomial infections (NIs) in hospital units with endemic S marcescens NI and to examine the mechanisms of soap colonization. University-affiliated tertiary-care hospitals. A prospective case-control study and an environmental investigation were performed to assess the relationship between S marcescens NIs in hospital units and S marcescens-contaminated soap. Soap-bottle use and handwashing practices were reviewed. Cultures of healthcare workers' (HCWs) hands were obtained before and after hand washing with soap. 5 of 7 hospital units with S marcescens NIs had soap bottles contaminated with S marcescens, compared to 1 of 14 other units (P=.006). After hand washing with an S marcescens-contaminated soap pump, HCWs' hands were 54 times more likely to be contaminated with S marcescens (Pliquid soap by S marcescens resulted in handborne transmission of S marcescens NIs by HCWs in our setting. This finding led to the application of strict guidelines for nonmedicated soap use and to the reinforcement of alcoholic hand disinfection.

  18. Koondise võistlustegevus / Elo Saue

    Index Scriptorium Estoniae

    Saue, Elo, 1972-

    2014-01-01

    Eesti orienteerumisjooksu koondise liikmete esinemisest Euroopa meistrivõistlustel Portugalis Palmelas 10.-16. aprillini ja Maailma Karika etappidel Kemeris 28. veebruarist 2. märtsini, Hispaanias Murcia-Cehegínis 5. ja 6. aprillil, Norras Kongsbergis 7. ja 8. juunil ning Soomes Imatras 11. ja 12. juunil

  19. When 'national innovation system' meet 'varieties of capitalism' arguments on labour qualifications: On the skill types and scientific knowledge needed for radical and incremental product innovations

    NARCIS (Netherlands)

    Herrmann, A.M.; Peine, A.

    2011-01-01

    The literatures on 'varieties of capitalism' (VoC) and 'national innovation systems' (NIS) propose very similar arguments about how firms require different types of labour qualifications to pursue strategies of radical product innovation (RPI), incremental product innovation (IPI), and product

  20. When ‘national innovation system’ meet ‘varieties of capitalism’ arguments on labour qualifications: On the skill types and scientific knowledge needed for radical and incremental product innovations

    NARCIS (Netherlands)

    Herrmann, A.M.; Peine, A.

    2012-01-01

    The literatures on ‘varieties of capitalism’ (VoC) and ‘national innovation systems’ (NIS) propose very similar arguments about how firms require different types of labour qualifications to pursue strategies of radical product innovation (RPI), incremental product innovation (IPI), and product

  1. NCBI nr-aa BLAST: CBRC-DNOV-01-1927 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-1927 ref|YP_001357187.1| hypothetical protein NIS_1724 [Nitratiruptor ...sp. SB155-2] dbj|BAF70830.1| conserved hypothetical protein [Nitratiruptor sp. SB155-2] YP_001357187.1 2.1 27% ...

  2. NATO and EU Need Not Enlarge Hand in Hand - Estonian President in Riga

    Index Scriptorium Estoniae

    2006-01-01

    Riias NATO tippkohtumise ajal toimunud rahvusvahelisel julgeolekukonverentsil esinenud president Toomas Hendrik Ilves toetas Euroopa Liidu edasist laienemist, kuid möönis ühenduses tekkinud nn. laienemisväsimust. Vabariigi President töövisiidil Läti Vabariiki ja Rootsi Kuningriiki 28.-30.11.2006

  3. New neutron-based isotopic analytical methods; An explorative study of resonance capture and incoherent scattering

    NARCIS (Netherlands)

    Perego, R.C.

    2004-01-01

    Two novel neutron-based analytical techniques have been treated in this thesis, Neutron Resonance Capture Analysis (NRCA), employing a pulsed neutron source, and Neutron Incoherent Scattering (NIS), making use of a cold neutron source. With the NRCA method isotopes are identified by the

  4. Incoherent neutron-scattering determination of hydrogen content : Theory and modeling

    NARCIS (Netherlands)

    Perego, R.C.; Blaauw, M.

    2005-01-01

    Hydrogen concentrations of 0 up to 350?mg/kg in a titanium alloy have been determined at National Institute of Standards and Technology (NIST) with neutron incoherent scattering (NIS) and with cold neutron prompt gamma activation analysis. The latter is a well-established technique, while the former

  5. Atomistic simulation of the structure and elastic properties of pyrite (FeS2) as a function of pressure

    CSIR Research Space (South Africa)

    Sithole, Happy M

    2003-10-01

    Full Text Available metal, NiS2 a paramagnetic Mott–Hubbard insulator, CuS2 a (metallic) superconductor and ZnS2 a diamagnetic insulator. Thus they attract a great deal of interest from both physicists and mineralogists, and of- fer a challenging group of minerals...

  6. Despite reprimand, minister pardons police chief / Ksenia Repson

    Index Scriptorium Estoniae

    Repson, Ksenia

    2005-01-01

    Siseminister Kalle Laanet möönis, et Politseiameti peadirektor Robert Antropov ei ole oma vanemaid politseisõidukiga Saaremaale toimetades reegleid rikkunud ning jättis tema lahkumispalve rahuldamata. Siiski karistas minister politseijuhti pooleaastase lisatasu kaotuse ja puhkuse tühistamisega

  7. Amputation Totale de La Verge: A Propos de Trois Observations

    Directory of Open Access Journals (Sweden)

    Kimassoum Rimtebaye

    2015-03-01

    Conclusion: qu’elle soit d’origine criminelle ou psychogène, l’amputation totale du pénis est rarissime. Les conséquences sont urinaires, sexuelles et psychogènes. La prise en charge doit être multidisciplinaire.

  8. EFFECT OF SUGAR CANE JUICE ON SLUMP VALUES FFECT OF ...

    African Journals Online (AJOL)

    eobe

    different percentages of unfermented sugar cane juice replacing some proportion of water in the concrete mix. .... the fruit market in D/Line area of Port Harcourt. .... [16] Neville A.M. 2006 . Properties of concrete. 4th ed.,. Dorling Kindersley, New Delhi, India. [17] NIS 235 (1987). Nigerian Industrial Standards. Standards for ...

  9. European Non Destructive Examination Forum (ENDEF)

    Energy Technology Data Exchange (ETDEWEB)

    Deffrennes, M [EC, DG XVII, Nuclear Energy, Brussels (Belgium); Engl, G [Siemens AG Energieerzeugung KWU, Erlangen (Germany); Estorff, U von [EC, JRC/IAM, Petten (Netherlands)

    1998-11-01

    ENDEF, an initiative of the European Commission, DG XVII (Energy) was well supported by the European industrial institutions working in assistance with nuclear industrial organisations in the CEEC`s (Central and Eastern European Countries) and NIS`s (New Independent States). This Forum provides effectively a platform for open discussion between representatives of industrial actors active in the NDE (Non Destructive Examination)/ISI (In Service Inspection) field with the purpose to establish a co-operation pattern between qualified representatives of the EU (European Union) industry to offer a better co-ordinated and well defined assistance to the CEEC`s and NIS in the field of NDE/ISI, and to lay the ground for further industrial co-operation. ENDEF developed a strategy to follow for the establishment of co-operation projects. This strategy is now used to understand the extent of past or present assistance projects and to identify the areas where more co-operation is needed. ENDEF encourages the creation in the NIS`s and CEEC`s of similar forums in order to increase the co-operation and co-ordination. ENDEF is also working in perfect agreement with the European Network ENIQ, piloted by the European plant operators. This identity of views lead to the leadership by the ENDEF co-ordinator of the ENIQ Task 3 involving Applications of the European Methodology for ISI qualification in the CEEC`s and NIS`s and presently fully integrated in ENDEF. (orig.)

  10. SAP crm integration testing

    OpenAIRE

    Černiavskaitė, Marija

    2017-01-01

    This Bachelor's thesis presents SAP CRM and integration systems testing analysis: investigation in SAP CRM and SAP PO systems, presentation of relationship between systems, introduction to third-party system (non-SAP) – Network Informational System (NIS) which has integration with SAP, presentation of best CRM testing practises, analysis and recommendation of integration testing. Practical integration testing is done in accordance to recommendations.

  11. U.S. EPA, Pesticide Product Label, RAMROD AND ATRAZINE FLOWABLE HERBICIDE, 09/03/1982

    Science.gov (United States)

    2011-04-14

    ... OF CCrn-"tl. i"''''i.I'I, Push f,b or ~\\iri 'f'::tb Illtnt_ of "gt~r !cr 3\\ '!3St 15 mh"~!J 'At .. ... te Il!td ~r other hertliC'd! ':an: .. !' tv e.!~~ jar mrhd ".itt·, .niS"" ~!lJJt'., ...

  12. Regioselective iodoazidation of alkynes: synthesis of α,α-diazidoketones.

    Science.gov (United States)

    Okamoto, Noriko; Sueda, Takuya; Minami, Hideki; Miwa, Yoshihisa; Yanada, Reiko

    2015-03-06

    Aryl alkyl alkynes reacted with N-iodosuccinimide (NIS) and trimethylsilyl azide (TMSN3), leading to α,α-diazidoketones via the regioselective addition of IN3 to alkynes. Huisgen cyclization of α,α-diazidoketones generated bis-triazole compounds.

  13. PROBLEMS AND PRIORITIES OF DEVELOPMENT OF DOMESTIC NANOINDUSTRY

    Directory of Open Access Journals (Sweden)

    Olga B. Lomakina

    2013-01-01

    Full Text Available Russia has a powerful groundwork in the field of nanotech. All prerequisites  are available in the country necessary to form an uptodate NIS. However the system of implementing innovation processes in the field of nanotechnologies and in the management of this branch of industry remains lowefficient.

  14. FORMATION OF LONG-TERM DEVELOPMENT STRATEGY OF INNOVATION ECONOMY IN RUSSIA

    Directory of Open Access Journals (Sweden)

    O. B. Lomakina

    2014-01-01

    Full Text Available Russiahas a powerful groundwork in the field of nanotech. All prerequisites are available in the country necessary to form an uptodateNIS. However the system of implementing innovation processes in the field of nanotechnologies and in the management of this branch of industry remains low efficient.

  15. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Paola Benzi1 2 Elena Bottizzo1 Chiara Demaria1 Nicoletta Rizzi1. Dipartimento di Chimica Generale ed Organica Applicata and NIS Centre of Excellence, Università degli Studi di Torino, Corso Massimo d'Azeglio 48, 10125 Torino; Istituto Nazionale di Fisica della Materia, Villa Brignole, Corso Perrone 24, 16152 Genova, ...

  16. Distinguishing Computer-Generated Graphics from Natural Images Based on Sensor Pattern Noise and Deep Learning

    Directory of Open Access Journals (Sweden)

    Ye Yao

    2018-04-01

    Full Text Available Computer-generated graphics (CGs are images generated by computer software. The rapid development of computer graphics technologies has made it easier to generate photorealistic computer graphics, and these graphics are quite difficult to distinguish from natural images (NIs with the naked eye. In this paper, we propose a method based on sensor pattern noise (SPN and deep learning to distinguish CGs from NIs. Before being fed into our convolutional neural network (CNN-based model, these images—CGs and NIs—are clipped into image patches. Furthermore, three high-pass filters (HPFs are used to remove low-frequency signals, which represent the image content. These filters are also used to reveal the residual signal as well as SPN introduced by the digital camera device. Different from the traditional methods of distinguishing CGs from NIs, the proposed method utilizes a five-layer CNN to classify the input image patches. Based on the classification results of the image patches, we deploy a majority vote scheme to obtain the classification results for the full-size images. The experiments have demonstrated that (1 the proposed method with three HPFs can achieve better results than that with only one HPF or no HPF and that (2 the proposed method with three HPFs achieves 100% accuracy, although the NIs undergo a JPEG compression with a quality factor of 75.

  17. A catalyst-free synthesis of germanium nanowires obtained by ...

    Indian Academy of Sciences (India)

    2015-08-25

    Aug 25, 2015 ... 1Dipartimento di Chimica and NIS Centre of Excellence, Università degli Studi di Torino, via Pietro Giuria 7, ..... Indeed, a test synthesis replying .... 48 5446. [27] Lu X T, Harris J T, Villareal J E, Chockla A M and Korgel B.

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    Energy Technology Data Exchange (ETDEWEB)

    Brim, Cornelia P.

    2014-10-01

    Because of her training and professional experiences, Rosalyn Leitch, a Security Specialist at Pacific Northwest National Laboratory and former Nonproliferation Graduate Fellow with NIS (2012-2013) was able to transition into temporary assignment as UNVIE Acting Nuclear Security Attaché from November 2013 through February 2014.

  19. Parimad noored lauljad on selgunud. Laval särasid noored lauljad / Ülle Jantson

    Index Scriptorium Estoniae

    Jantson, Ülle

    2007-01-01

    Pärnu linna ja maakonna noorte solistide konkursist "Sügisulg" (produtsendiks Helen Erastus), mille võitjad esindavad Pärnumaad üle-eestilisel laulukonkursil "Laulukarussell 2008". Finaalkontsertidest 10.-19aastastele 23. nov. Pärnu kontserdimajas ja 3-9aastastele 25. nov. Endla teatri Küünis, nimekiri võitjatest

  20. "Sügisulg" toob noored anded suurele lavale / Silja Joon

    Index Scriptorium Estoniae

    Joon, Silja, 1966-

    2007-01-01

    Pärnu linna ja maakonna noorte solistide konkursist "Sügisulg" (produtsendiks Helen Erastus), mille võitjad esindavad Pärnumaad üle-eestilisel laulukonkursil "Laulukarussell 2008" (finaalkontserdid 10.-19aastastele 23. nov. Pärnu kontserdimajas ja 3-9aastastele 25. nov. Endla teatri Küünis, finalistid vt. www.parnukontsert.ee)