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Sample records for natrium-iodid-symporter nis bedeutung

  1. Deteksi Natrium/Iodide Symporter (NIS pada Galur Sel Kanker Payudara SKBR3 dengan Imunositofluoresens

    Directory of Open Access Journals (Sweden)

    Aisyah Elliyanti

    2016-03-01

    Full Text Available SKBR-3 cell line is a breast cancer model for human epidermal growth factor receptor2 (HER2 positive. Only 50% of patients of this type have fully responded to chemotherapy. Natrium iodide symporter expression correlates with the uptake and ability of cells to accumulate radioiodine. The aim of this study was to examine natrium/iodide symporter (NIS expression and its distribution with and without epidermal growth factor (EGF treatment using immunocytofluoresence (ICF. This study was conducted at the Cell Culture Laboratory, Faculty of Medicine, Universitas Padjadjaran from September 2013 to April 2014. SKBR3 cells were cultured until 70% confluent. Cells were then divided into two groups: treatment group and control group. The treatment group was treated with EGF 50 ng/mL. Cells were incubated with primary antibody rabbit polyclonal antibody anti-NIS, and then were followed with secondary-antibody goat polyclonal antibody to rabbit. Data from the observation were then assessed semi-quantitatively. Natrium/iodide symporter was seen to be expressed and distributed in the cytoplasm. Cells induced by EGF showed significant increase in NIS expression in cytoplasm and its distribution in cell membrane. It is concluded that the SKBR3 cells express NIS in cytoplasm and that EGF induction increases NIS expression and distribution in cell membrane. This finding leads to a potential ability of breast cancer cells to uptake and accumulate radioiodine.

  2. Molecular and structural characterisation of the human sodium/iodide symporter (h N.I.S.) C-terminus and the implication of this domain in the transporter regulation; Caracterisation moleculaire et structurale de l'extremite C-Terminale du co-transporteur sodium/iode humain (h N.I.S.): Implication de ce domaine dans la regulation du transporteur

    Energy Technology Data Exchange (ETDEWEB)

    Huc, S

    2007-12-15

    The human natrium iodide symporter (h N.I.S.) is an intrinsic membrane protein expressed in thyroid cells where it allows iodide uptake and accumulation. It is composed of thirteen transmembrane helices and its ninety- three amino acids long cytosolic C-terminus presents many potential post-translational regulatory sites. A first part of the PhD work has been dedicated to the expression in a bacterial system and to the purification of the cytosolic C-terminal fragment. Biochemical and structural characterisation have revealed that this C-terminus is very flexible but prone to dimerization. The fragment has also been used as a bait to test the interactions with PDZ domain proteins spotted on a membrane. Several proteins interacting with the (natrium/iodide symporter) N.I.S. C-terminus have thus been identified and the study of their implication in the protein regulation has been initiated. A second part of the work has underlined the existence of a N.I.S. fragment co-purified with the entire protein. This fragment has been found in cells in culture stably expressing N.I.S. and also in human thyroid extracts and in rodent thyroid cells. We observed that this fragment is spontaneously associated with the entire protein. It is composed of the last 131 amino acid of the protein and so comprises the last transmembrane domain and the C-terminal extremity. The expression of a truncated form of h N.I.S., lacking the last 131 amino acids, shows that this protein is not correctly addressed to the cell membrane and cells expressing this mutated symporter cannot accumulate iodide. However, our results show that the co-expression of the two N.I.S. parts, the truncated form lacking the last 131 amino acid, and the complementary C-terminal fragment, leads to cells presenting 10 % of the activity of cells expressing the whole N.I.S.. (author)

  3. Distinct contributions of the nisin biosynthesis enzymes NisB and NisC and transporter NisT to prenisin production by Lactococcus lactis

    NARCIS (Netherlands)

    van Saparoea, H. Bart van den Berg; Bakkes, Patrick J.; Moll, Gert N.; Driessen, Arnold J. M.

    2008-01-01

    Several Lactococcus lactis strains produce the lantibiotic nisin. The dedicated enzymes NisB and NisC and the transporter NisT modify and secrete the ribosomally synthesized nisin precursor peptide. NisB can function in the absence of the cyclase NisC, yielding the dehydrated prenisin that lacks the

  4. Volkswirtschaftliche Bedeutung der biobasierten Wirtschaft in Deutschland

    OpenAIRE

    Efken, Josef; Banse, Martin; Rothe, Andrea; Dieter, Matthias; Dirksmeyer, Walter; Ebeling, Michael; Fluck, Katrin; Hansen, Heiko; Kreins, Peter; Seintsch, Björn; Schweinle, Jörg; Strohm, Kathrin; Weimar, Holger

    2012-01-01

    Das Thünen-Institut wurde vom Bundesministerium für Ernährung, Landwirtschaft und Verbraucherschutz (BMELV) gebeten, die volkswirtschaftliche Bedeutung der biobasierten Wirtschaft in Deutschland zu kalkulieren. Grundlage bildet die vom Bioökonomierat der Bundesregierung aufgestellte Definition der biobasierten Wirtschaft als alle wirtschaftlichen Sektoren und ihre dazugehörigen Dienstleistungen, die biologische Ressourcen produzieren, be- und verarbeiten oder in irgendeiner Form nutzen. Mithi...

  5. Physics and Applications of NIS Junctions

    Energy Technology Data Exchange (ETDEWEB)

    Ullom, J N

    2001-08-24

    This paper reviews the physics and applications of Normal-Insulator-Superconductor (NIS) tunnel junctions. The current-voltage properties of NIS junctions are diode-like with a strong temperature dependence. Hence, these structures can be used as sensitive thermometers at temperatures well below the energy gap, {Delta}, of the superconducting electrode. For junction voltages comparable to {Delta}/q, current flow removes energy from the normal electrode. This property has been exploited to build refrigerators capable of cooling thin-film circuits from 0.3 K to 0.1 K. Calorimeters and bolometers for the detection of X-rays and millimeter-wave radiation, respectively, have successfully been built from NIS junctions. NIS junctions have also been used to probe the superconducting state. Finally, recent ideas for the use of NIS junctions as simple circuit elements are described.

  6. Molecular imaging using sodium iodide symporter (NIS)

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Je Yoel [School of Dentistry, Kyungpook National Univ., Daegu (Korea, Republic of)

    2004-04-01

    Radioiodide uptake in thyroid follicular epithelial cells, mediated by a plasma membrane transporter, sodium iodide symporter (NIS), provides a first step mechanism for thyroid cancer detection by radioiodide injection and effective radioiodide treatment for patients with invasive, recurrent, and/or metastatic thyroid cancers after total thyroidectomy. NIS gene transfer to tumor cells may significantly and specifically enhance internal radioactive accumulation of tumors following radioiodide administration, and result in better tumor control. NIS gene transfers have been successfully performed in a variety of tumor animal models by either plasmid-mediated transfection or virus (adenovirus or retrovirus)-mediated gene delivery. These animal models include nude mice xenografted with human melanoma, glioma, breast cancer of prostate cancer, rats with subcutaneous thyroid tumor implantation, as well as the rat intracranial glioma model. In these animal models, non-invasive imaging of in vivo tumors by gamma camera scintigraphy after radioiodide or technetium injection has been performed successfully, suggesting that the NIS can serve as an imaging reporter gene for gene therapy trials. In addition, the tumor killing effects of I-131, ReO4-188 and At-211 after NIS gene transfer have been demonstrated in in vitro clonogenic assays and in vivo radioiodide therapy studies, suggesting that NIS gene can also serve as a therapeutic requires a more efficient and specific system of gene delivery with better retention of radioiodide in tumor. Results thus far are, however, promising, and suggest that NIS gene transfer followed by radioiodide treatment will allow non-invasive in vivo imaging to assess the outcome of gene therapy and provide a therapeutic strategy for a variety of human diseases.

  7. Function of Lactococcus lactis Nisin Immunity Genes nisI and nisFEG after Coordinated Expression in the Surrogate Host Bacillus subtilis

    National Research Council Canada - National Science Library

    Torsten Stein; Stefan Heinzmann; Irina Solovieva; Karl-Dieter Entian

    ...) genes nisI , nisF , nisE , and nisG . Different combinations of nisin immunity genes were integrated into the chromosome of a nisin-sensitive Bacillus subtilis host strain under the control of an inducible promoter...

  8. Determining sites of interaction between prenisin and its modification enzymes NisB and NisC

    NARCIS (Netherlands)

    Khusainov, Rustem; Heils, Rene; Lubelski, Jacek; Moll, Gert N.; Kuipers, Oscar P.

    2011-01-01

    Although nisin is a model lantibiotic, our knowledge of the specific interactions of prenisin with its modification enzymes remains fragmentary. Here, we demonstrate that the nisin modification enzymes NisB and NisC can be pulled down in vitro from Lactococcus lactis by an engineered His-tagged pren

  9. Gesund aufwachsen – Welche Bedeutung kommt dem sozialen Status zu?

    OpenAIRE

    Lampert, Thomas; Kuntz, Benjamin

    2015-01-01

    Deutschland gehört zu den reichsten Ländern der Welt und verfügt über ein gut ausgebautes Sozialversicherungssystem. Dennoch wachsen auch hierzulande nicht alle Kinder und Jugendlichen unter den gleichen Lebensbedingungen auf. Die Ausgabe 1/2015 der Reihe GBE kompakt geht der Frage nach, welche Bedeutung dem sozialen Status beim gesunden Aufwachsen zukommt. Die Autoren untersuchen, ob sich soziale Ungleichheit im Gesundheitszustand, dem Gesundheitsverhalten und der Gesundheitsversorgung von K...

  10. HCUP National (Nationwide) Inpatient Sample (NIS) - Restricted Access File

    Data.gov (United States)

    U.S. Department of Health & Human Services — The NIS is the largest publicly available all-payer inpatient care database in the United States. It contains data from approximately 8 million hospital stays each...

  11. Identification of distinct nisin leader peptide regions that determine interactions with the modification enzymes NisB and NisC.

    Science.gov (United States)

    Khusainov, Rustem; Moll, Gert N; Kuipers, Oscar P

    2013-01-01

    Nisin is the most prominent and applied bacteriocin that serves as a model for class I lantibiotics. The nisin leader peptide importantly determines interactions between precursor nisin and its modification enzymes NisB and NisC that mature nisin posttranslationally. NisB dehydrates serines and threonines, while NisC catalyzes the subsequent coupling of the formed dehydroamino acids to form lanthionines. Currently, little is known about how the nisin leader interacts with NisB and even less is known about its interactions with NisC. To investigate the nisin leader peptide requirements for functional interaction with the modification enzymes NisB and NisC, we systematically replaced six regions, of 2-4 amino acids each, with all-alanine regions. By performing NisB and NisC co-purification studies with these mutant leader peptides, we demonstrate that the nisin leader regions STKD(-22-19), FNLD(-18-15) and PR(-2-1) importantly contribute to the interactions of precursor nisin with both NisB and NisC, whereas the nisin leader region LVSV(-14-11) additionally contributes to the interaction of precursor nisin with NisC.

  12. Identification of distinct nisin leader peptide regions that determine interactions with the modification enzymes NisB and NisC

    NARCIS (Netherlands)

    Khusainov, Rustem; Moll, Gert N.; Kuipers, Oscar P.

    2013-01-01

    Nisin is the most prominent and applied bacteriocin that serves as a model for class I lantibiotics. The nisin leader peptide importantly determines interactions between precursor nisin and its modification enzymes NisB and NisC that mature nisin posttranslationally. NisB dehydrates serines and thre

  13. Identification of distinct nisin leader peptide regions that determine interactions with the modification enzymes NisB and NisC

    NARCIS (Netherlands)

    Khusainov, Rustem; Moll, Gert N.; Kuipers, Oscar P.

    2013-01-01

    Nisin is the most prominent and applied bacteriocin that serves as a model for class I lantibiotics. The nisin leader peptide importantly determines interactions between precursor nisin and its modification enzymes NisB and NisC that mature nisin posttranslationally. NisB dehydrates serines and thre

  14. Function of Lactococcus lactis nisin immunity genes nisI and nisFEG after coordinated expression in the surrogate host Bacillus subtilis.

    Science.gov (United States)

    Stein, Torsten; Heinzmann, Stefan; Solovieva, Irina; Entian, Karl-Dieter

    2003-01-03

    Nisin-producing Lactococcus lactis strains show a high degree of resistance to the action of nisin, which is based upon expression of the self-protection (immunity) genes nisI, nisF, nisE, and nisG. Different combinations of nisin immunity genes were integrated into the chromosome of a nisin-sensitive Bacillus subtilis host strain under the control of an inducible promoter. For the recipient strain, the highest level of acquired nisin tolerance was achieved after coordinated expression of all four nisin immunity genes. But either the lipoprotein NisI or the ABC transporter-homologous system NisFEG, respectively, were also able to protect the Bacillus host cells. The acquired immunity was specific to nisin and provided no tolerance to subtilin, a closely related lantibiotic. Quantitative in vivo peptide release assays demonstrated that NisFEG diminished the quantity of cell-associated nisin, providing evidence that one role of NisFEG is to transport nisin from the membrane into the extracellular space. NisI solubilized from B. subtilis membrane vesicles and recombinant hexahistidine-tagged NisI from Escherichia coli interacted specifically with nisin and not with subtilin. This suggests a function of NisI as a nisin-intercepting protein.

  15. The distribution of work performed on a NIS junction

    DEFF Research Database (Denmark)

    Santos, Jaime Eduardo Vieira da Silva Moutinho; Ribeiro, Pedro; Kirchner, Stefan

    2016-01-01

    results are based on an equivalence between the dynamics of the NIS junction and that of an assembly of two-level systems subjected to a circularly polarised field, for which we can determine the work-characteristic function exactly. The average work dissipated by the NIS junction, as well as its...... fluctuations, are determined. From the work characteristic function, we also compute the work probability-distribution and show that it does not have a Gaussian character. Our results allow for a direct experimental test of the Crooks–Tasaki fluctuation relation.......We propose an experimental setup to measure the work performed in a normal-metal/insulator/superconducting (NIS) junction, subjected to a voltage change and in contact with a thermal bath. We compute the performed work and argue that the associated heat release can be measured experimentally. Our...

  16. Validation of NIS 500 MPa hydraulic pressure measurement

    Directory of Open Access Journals (Sweden)

    Eltawil Alaaeldin A.

    2017-01-01

    Full Text Available 500 MPa pressure is considered as the common maximum pressure in most of the National Metrology Institutes worldwide; however, validation of the uncertainty in that range required a lot of work. NIS when recognized on, 2008 guaranteed big uncertainty value above 200 MPa due to the absence of international comparison at that time. This paper summarizes the results of a validation of 500 MPa range of hydraulic gauge pressure measurements carried out at NIS. The study covers the calibration through direct comparison and through using of a pressure sensor. The paper summarized the technical work carried out at the results of measurements and the effect of these results on NIS Calibration Measurements Capability. The validation also includes the comparison between the obtained results and pervious calibration of the same piston-cylinder assembly that calibrated against the NIST primary standard.

  17. DEVELOPMENT OF A SCREENING APPROACH TO DETECT THYROID DISRUPTING CHEMICALS THAT INHIBIT THE HUMAN SODIUM IODIDE SYMPORTER (NIS)

    Data.gov (United States)

    U.S. Environmental Protection Agency — Data pertaining to a NIS-expressing cell line, hNIS-HEK293T-EPA, and its screening capabilities for determining inhibitors of NIS-mediated iodide uptake. This...

  18. The presence of modifiable residues in the core peptide part of precursor nisin is not crucial for precursor nisin interactions with NisB- and NisC.

    Directory of Open Access Journals (Sweden)

    Rustem Khusainov

    Full Text Available Precursor nisin is a model posttranslationally modified precursor lantibiotic that can be structurally divided into a leader peptide sequence and a modifiable core peptide part. The nisin core peptide clearly plays an important role in the precursor nisin-nisin modification enzymes interactions, since it has previously been shown that the construct containing only the nisin leader sequence is not sufficient to pull-down the nisin modification enzymes NisB and NisC. Serines and threonines in the core peptide part are the residues that NisB specifically dehydrates, and cysteines are the residues that NisC stereospecifically couples to the dehydrated amino acids. Here, we demonstrate that increasing the number of negatively charged residues in the core peptide part of precursor nisin, which are absent in wild-type nisin, does not abolish binding of precursor nisin to the modification enzymes NisB and NisC, but dramatically decreases the antimicrobial potency of these nisin mutants. An unnatural precursor nisin variant lacking all serines and threonines in the core peptide part and an unnatural precursor nisin variant lacking all cysteines in the core peptide part still bind the nisin modification enzymes NisB and NisC, suggesting that these residues are not essential for direct interactions with the nisin modification enzymes NisB and NisC. These results are important for lantibiotic engineering studies.

  19. hNIS-IRES-eGFP Dual Reporter Gene Imaging

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    Jiantu Che

    2005-04-01

    Full Text Available The human and rodent sodium iodide symporters (NIS have recently been cloned and are being investigated as potential therapeutic and reporter genes. We have extended this effort by constructing an internal ribosomal entry site (IRES-linked human NIS (hNIS-enhanced green fluorescent protein (eGFP hybrid reporter gene for both nuclear and optical imaging. A self-inactivating retroviral vector, termed pQCNIG, containing hNIS-IRES-eGFP dual reporter gene, driven by a constitutive CMV promoter, was constructed and used to generate RG2-pQCNIG cells and RG2-pQCNIG tumors. 131I-iodide and 99mTcO4-pertechnetate accumulation studies plus fluorescence microscopy and intensity assays were performed in vitro, and gamma camera imaging studies in RG2-pQCNIG and RG2 tumor-bearing athymic rats were performed. RG2-pQCNIG cells expressed high levels of hNIS protein and showed high intensity of eGFP fluorescence compared with RG2 wild-type cells. RG2-pQCNIG cells accumulated Na131I and 99mTcO4– to a 50:1 and a 170:1 tissue/medium ratio at 10 min, compared with 0.8:1.2 tissue/medium ratio in wild-type RG2 cells. A significant correlation between radiotracer accumulation and eGFP fluorescence intensity was demonstrated. RG2-pQCNIG and RG2 tumors were readily differentiated by in vivo gamma camera imaging; radiotracer uptake increased in RG2-pQCNIG but declined in RG2 tumors over the 50-min imaging period. Stomach and thyroid were the major organs of radionuclide accumulation. The IRES-linked hNIS-eGFP dual reporter gene is functional and stable in transduced RG2-pQCNIG cells. Optical and nuclear imaging of tumors produced from these cell lines provides the opportunity to monitor tumor growth and response to therapy. These studies indicate the potential for a wider application of hNIS reporter imaging and translation into patient studies using radioisotopes that are currently available for human use for both SPECT and PET imaging.

  20. Glycosylation of Sodium/Iodide Symporter (NIS) Regulates Its Membrane Translocation and Radioiodine Uptake

    OpenAIRE

    Taemoon Chung; Hyewon Youn; Chan Joo Yeom; Keon Wook Kang; June-Key Chung

    2015-01-01

    Purpose Human sodium/iodide symporter (hNIS) protein is a membrane glycoprotein that transports iodide ions into thyroid cells. The function of this membrane protein is closely regulated by post-translational glycosylation. In this study, we measured glycosylation-mediated changes in subcellular location of hNIS and its function of iodine uptake. Methods HeLa cells were stably transfected with hNIS/tdTomato fusion gene in order to monitor the expression of hNIS. Cellular localization of hNIS ...

  1. Microarray analysis of genes associated with cell surface NIS protein levels in breast cancer

    Directory of Open Access Journals (Sweden)

    Richardson Andrea L

    2011-10-01

    Full Text Available Abstract Background Na+/I- symporter (NIS-mediated iodide uptake allows radioiodine therapy for thyroid cancer. NIS is also expressed in breast tumors, raising potential for radionuclide therapy of breast cancer. However, NIS expression in most breast cancers is low and may not be sufficient for radionuclide therapy. We aimed to identify biomarkers associated with NIS expression such that mechanisms underlying NIS modulation in human breast tumors may be elucidated. Methods Published oligonucleotide microarray data within the National Center for Biotechnology Information Gene Expression Omnibus database were analyzed to identify gene expression tightly correlated with NIS mRNA level among human breast tumors. NIS immunostaining was performed in a tissue microarray composed of 28 human breast tumors which had corresponding oligonucleotide microarray data available for each tumor such that gene expression associated with cell surface NIS protein level could be identified. Results and Discussion NIS mRNA levels do not vary among breast tumors or when compared to normal breast tissues when detected by Affymetrix oligonucleotide microarray platforms. Cell surface NIS protein levels are much more variable than their corresponding NIS mRNA levels. Despite a limited number of breast tumors examined, our analysis identified cysteinyl-tRNA synthetase as a biomarker that is highly associated with cell surface NIS protein levels in the ER-positive breast cancer subtype. Conclusions Further investigation on genes associated with cell surface NIS protein levels within each breast cancer molecular subtype may lead to novel targets for selectively increasing NIS expression/function in a subset of breast cancers patients.

  2. The Sodium Iodide Symporter (NIS) and Potential Regulators in Normal, Benign and Malignant Human Breast Tissue

    OpenAIRE

    James Ryan; Curran, Catherine E.; Emer Hennessy; John Newell; Morris, John C.; Kerin, Michael J.; Dwyer, Roisin M

    2011-01-01

    INTRODUCTION: The presence, relevance and regulation of the Sodium Iodide Symporter (NIS) in human mammary tissue remains poorly understood. This study aimed to quantify relative expression of NIS and putative regulators in human breast tissue, with relationships observed further investigated in vitro. METHODS: Human breast tissue specimens (malignant n = 75, normal n = 15, fibroadenoma n = 10) were analysed by RQ-PCR targeting NIS, receptors for retinoic acid (RARα, RARβ), oestrogen (ERα), t...

  3. The sodium iodide symporter (NIS and potential regulators in normal, benign and malignant human breast tissue.

    Directory of Open Access Journals (Sweden)

    James Ryan

    Full Text Available INTRODUCTION: The presence, relevance and regulation of the Sodium Iodide Symporter (NIS in human mammary tissue remains poorly understood. This study aimed to quantify relative expression of NIS and putative regulators in human breast tissue, with relationships observed further investigated in vitro. METHODS: Human breast tissue specimens (malignant n = 75, normal n = 15, fibroadenoma n = 10 were analysed by RQ-PCR targeting NIS, receptors for retinoic acid (RARα, RARβ, oestrogen (ERα, thyroid hormones (THRα, THRβ, and also phosphoinositide-3-kinase (PI3K. Breast cancer cells were treated with Retinoic acid (ATRA, Estradiol and Thyroxine individually and in combination followed by analysis of changes in NIS expression. RESULTS: The lowest levels of NIS were detected in normal tissue (Mean(SEM 0.70(0.12 Log(10 Relative Quantity (RQ with significantly higher levels observed in fibroadenoma (1.69(0.21 Log(10RQ, p<0.005 and malignant breast tissue (1.18(0.07 Log(10RQ, p<0.05. Significant positive correlations were observed between human NIS and ERα (r = 0.22, p<0.05 and RARα (r = 0.29, p<0.005, with the strongest relationship observed between NIS and RARβ (r = 0.38, p<0.0001. An inverse relationship between NIS and PI3K expression was also observed (r =  0.21, p<0.05. In vitro, ATRA, Estradiol and Thyroxine individually stimulated significant increases in NIS expression (range 6-16 fold, while ATRA and Thyroxine combined caused the greatest increase (range 16-26 fold. CONCLUSION: Although NIS expression is significantly higher in malignant compared to normal breast tissue, the highest level was detected in fibroadenoma. The data presented supports a role for retinoic acid and estradiol in mammary NIS regulation in vivo, and also highlights potential thyroidal regulation of mammary NIS mediated by thyroid hormones.

  4. The sodium iodide symporter (NIS) and potential regulators in normal, benign and malignant human breast tissue.

    LENUS (Irish Health Repository)

    Ryan, James

    2011-01-01

    The presence, relevance and regulation of the Sodium Iodide Symporter (NIS) in human mammary tissue remains poorly understood. This study aimed to quantify relative expression of NIS and putative regulators in human breast tissue, with relationships observed further investigated in vitro.

  5. Expression of the human sodium/iodide symporter (hNIS) in xenotransplanted human thyroid carcinoma

    NARCIS (Netherlands)

    Smit, J.W.A.; Schröder - van der Elst, J.P.; Karperien, M.; Que, I.; Romijn, J.A.; Heide, van der D.

    2001-01-01

    The uptake of iodide in thyroid epithelial cells is mediated by the sodium/iodide symporter (NIS). The uptake of iodide is of vital importance for thyroid physiology and is a prerequisite for radioiodine therapy in thyroid cancer. Loss of iodide uptake due to diminished expression of the human NIS (

  6. The sodium iodide symporter (NIS) and potential regulators in normal, benign and malignant human breast tissue.

    Science.gov (United States)

    Ryan, James; Curran, Catherine E; Hennessy, Emer; Newell, John; Morris, John C; Kerin, Michael J; Dwyer, Roisin M

    2011-01-19

    The presence, relevance and regulation of the Sodium Iodide Symporter (NIS) in human mammary tissue remains poorly understood. This study aimed to quantify relative expression of NIS and putative regulators in human breast tissue, with relationships observed further investigated in vitro. Human breast tissue specimens (malignant n = 75, normal n = 15, fibroadenoma n = 10) were analysed by RQ-PCR targeting NIS, receptors for retinoic acid (RARα, RARβ), oestrogen (ERα), thyroid hormones (THRα, THRβ), and also phosphoinositide-3-kinase (PI3K). Breast cancer cells were treated with Retinoic acid (ATRA), Estradiol and Thyroxine individually and in combination followed by analysis of changes in NIS expression. The lowest levels of NIS were detected in normal tissue (Mean(SEM) 0.70(0.12) Log(10) Relative Quantity (RQ)) with significantly higher levels observed in fibroadenoma (1.69(0.21) Log(10)RQ, phuman NIS and ERα (r = 0.22, pfibroadenoma. The data presented supports a role for retinoic acid and estradiol in mammary NIS regulation in vivo, and also highlights potential thyroidal regulation of mammary NIS mediated by thyroid hormones.

  7. Structure of the nisin leader peptidase NisP revealing a C-terminal autocleavage activity.

    Science.gov (United States)

    Xu, Yueyang; Li, Xin; Li, Ruiqing; Li, Shanshan; Ni, Hongqian; Wang, Hui; Xu, Haijin; Zhou, Weihong; Saris, Per E J; Yang, Wen; Qiao, Mingqiang; Rao, Zihe

    2014-06-01

    Nisin is a widely used antibacterial lantibiotic polypeptide produced by Lactococcus lactis. NisP belongs to the subtilase family and functions in the last step of nisin maturation as the leader-peptide peptidase. Deletion of the nisP gene in LAC71 results in the production of a non-active precursor peptide with the leader peptide unremoved. Here, the 1.1 Å resolution crystal structure of NisP is reported. The structure shows similarity to other subtilases, which can bind varying numbers of Ca atoms. However, no calcium was found in this NisP structure, and the predicted calcium-chelating residues were placed so as to not allow NisP to bind a calcium ion in this conformation. Interestingly, a short peptide corresponding to its own 635-647 sequence was found to bind to the active site of NisP. Biochemical assays and native mass-spectrometric analysis confirmed that NisP possesses an auto-cleavage site between residues Arg647 and Ser648. Further, it was shown that NisP mutated at the auto-cleavage site (R647P/S648P) had full catalytic activity for nisin leader-peptide cleavage, although the C-terminal region of NisP was no longer cleaved. Expressing this mutant in L. lactis LAC71 did not affect the production of nisin but did decrease the proliferation rate of the bacteria, suggesting the biological significance of the C-terminal auto-cleavage of NisP.

  8. Air quality monitoring in NIS (SERBIA) and health impact assessment.

    Science.gov (United States)

    Nikic, Dragana; Bogdanovic, Dragan; Nikolic, Maja; Stankovic, Aleksandra; Zivkovic, Nenad; Djordjevic, Amelija

    2009-11-01

    The aim of this study is to indicate the significance of air quality monitoring and to determine the air quality fields for the assessment of air pollution health effects, with special attention to risk population. Radial basis function network was used for air quality index mapping. Between 1991 and 2005, on the territory of Nis, several epidemiological studies were performed on risk groups (pre-school children, school children, pregnant women and persons older than 65). The total number of subjects was 5837. The exposed group comprised individuals living in the areas with unhealthy AQI, while the control group comprised individuals living in city areas with good or moderate AQI. It was determined that even relatively low levels of air pollution had impact on respiratory system and the occurrence of anaemia, allergy and skin symptoms.

  9. Biologie des Geruchs: Die Bedeutung von Pheromonen für Verhalten und Reproduktion

    Directory of Open Access Journals (Sweden)

    Atzmüller M

    2000-01-01

    Full Text Available Dieser Artikel geht der Frage nach dem Vorkommen und der Wirkung von Pheromonen beim Menschen nach. Es wird der Status quo der Geruchsforschung aufgezeigt und ein Überblick über die Voraussetzungen der Geruchskommunikation geboten. Über Beispiele aus dem Tierreich wird zu ihrem Vorkommen und ihrer Bedeutung beim Menschen geführt. So hat sich in den letzten Jahren gezeigt, daß besonders die Geruchsstoffe aus dem Schweiß das Potential besitzen, menschliches Verhalten nachweislich zu beeinflussen. Darüber hinaus zeigt sich, daß auch die menschliche Reproduktion dem Einfluß von Pheromonen zu unterliegen scheint. Die Bedeutung der Geruchskommunikation beim Menschen wird größtenteils noch immer unterschätzt, obwohl sie durchaus das Potential für zukünftigen medizinischen Einsatz zu bergen scheint.

  10. On the similarity of the bonding in NiS and NiO

    Science.gov (United States)

    Bauschlicher, C. W., Jr.

    1985-01-01

    The bonding in NiS is found to be quite similar to that in NiO, having an ionic contribution arising from the donation of the Ni 4s electron to the S atom and a covalent component arising from bonds between the Ni 3d and the S 3p. The one-electron d bonds are found to be of equal strength for NiO and NiS, but the two-electron d bonds are weaker for NiS.

  11. Baculovirus vector-mediated transfer of NIS gene into colon tumor cells for radionuclide therapy

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    AIM:To investigate the feasibility of radionuclide therapy of colon tumor cells by baculovirus vector-mediated transfer of the sodium/iodide symporter(NIS) gene.METHODS:A recombinant baculovirus plasmid carrying the NIS gene was constructed,and the viruses(BacNIS) were prepared using the Bac-to-Bac system.The infection efficiency in the colon cancer cell line SW1116 of a green fluorescent protein(GFP) expressing baculovirus(Bac-GFP) at different multiplicities of infection(MOI) with various concentrations o...

  12. Die Bedeutung von "Familie": Erzählungen aus drei Generationen

    OpenAIRE

    Mora Salas, Leonor

    2008-01-01

    Gegenstand meines Beitrages ist die Frage, wie Familien Sinn und Bedeutung des Begriffes "Familie" konstruieren. Die hier vorgestellte Theorie geht auf die Analyse von vier früheren qualitativen Untersuchungen zurück, in denen individuelle Interviews mit Mitgliedern von insgesamt 14 Familien unterschiedlicher sozioökonomischer Herkunft in Caracas, Venezuela, durchgeführt wurden. In jedem einzelnen Fall wurden Mitglieder aus drei unterschiedlichen Generationen interviewt, in deren Erzählungen ...

  13. Untersuchung der Apoptose in kardialen und kardiovaskulären Erkrankungen: Bedeutung von Stickstoffmonoxid

    OpenAIRE

    Weiland, Ulrike

    2005-01-01

    Die Bedeutung der Apoptose und die zugrundeliegenden Mechanismen in verschiedenen pathophysiologischen Zuständen des Herzens sind noch weitgehend ungeklärt und es bleibt zu zeigen, daß die Apoptose-Signaltransduktion ähnlich reguliert wird, wie aus in vitro-Versuchen bekannt ist. Deshalb wurde die Apoptose in verschiedenen Tiermodellen kardialer Erkrankungen untersucht werden, um Hinweise auf die zugrundeliegende Signal-transduktion, durch Analyse der Proteine Bcl-2 und Bax, der fina...

  14. Bedeutung des Gemüsebaus für die Landwirtschaft von Wielkopolska

    Directory of Open Access Journals (Sweden)

    Karolina Jąder

    2009-01-01

    Full Text Available In dem Artikel wurde die Bedeutung des Gemüsebaus für die Landwirtschaft der Region Wielkopolska präsentiert. Diese Bedeutung wurde mit Hilfe von einigen Kriterien bestimmt. Es wurden dargestellt: der Anteil der Gemüsefläche an der gesamten landwirtschaftlichen Nutzfläche von Wielkopolska und der Gemüseanteil in der Brutto- und Warenproduktion der regionalen Landwirtschaft und der Pflanzenabteilung. Der Anteil der Freilandgemüsefläche an der landwirtschaftlichen Nutzfläche lag bei 1,36 bis 1,56 Prozent und der Anteil der Gewächshausgemüsefläche an der landwirtschaftlichen Nutzfläche oszillierte von 0,017 bis 0,050 Prozent. Die Gemüseproduktion lag bei 4,67 Prozent der Bruttoproduktion der Landwirtschaft von Wielkopolska, und der Anteil der Gemüseproduktion an der Warenproduktion der Landwirtschaft war in der Zeit auf einem ähnlichen Niveau – 4,66 Prozent. In der Pflanzenabteilung war die Bedeutung des Gemüsebaus noch größer als in der ganzen Landwirtschaft. Der Anteil von Gemüse an der Warenproduktion der Pflanzenabteilung lag durchschnittlich in den untersuchten Jahren bei 28, 54 Prozent.

  15. Use of the Lactococcal nisA Promoter To Regulate Gene Expression in Gram-Positive Bacteria : Comparison of Induction Level and Promoter Strength

    NARCIS (Netherlands)

    Eichenbaum, Zehava; Federle, Michael J.; Marra, Diana; Vos, Willem M. de; Kuipers, Oscar P.; Kleerebezem, Michiel; Scott, June R.

    1998-01-01

    We characterized the regulated activity of the lactococcal nisA promoter in strains of the gram-positive species Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus pneumoniae, Enterococcus faecalis, and Bacillus subtilis. nisA promoter activity was dependent on the proteins NisR and Nis

  16. Hexagonal NiS nanobelts as advanced cathode materials for rechargeable Al-ion batteries.

    Science.gov (United States)

    Yu, Zhijing; Kang, Zepeng; Hu, Zongqian; Lu, Jianhong; Zhou, Zhigang; Jiao, Shuqiang

    2016-08-16

    Hexagonal NiS nanobelts served as novel cathode materials for rechargeable Al-ion batteries based on an AlCl3/[EMIm]Cl ionic liquid electrolyte system. The nano-banded structure of the materials can facilitate the electrolyte immersion and enhance Al(3+) diffusion. The hexagonal NiS nanobelt based cathodes exhibit high storage capacity, good cyclability and low overpotential.

  17. The Solution Structure of the Lantibiotic Immunity Protein NisI and Its Interactions with Nisin.

    Science.gov (United States)

    Hacker, Carolin; Christ, Nina A; Duchardt-Ferner, Elke; Korn, Sophie; Göbl, Christoph; Berninger, Lucija; Düsterhus, Stefanie; Hellmich, Ute A; Madl, Tobias; Kötter, Peter; Entian, Karl-Dieter; Wöhnert, Jens

    2015-11-27

    Many Gram-positive bacteria produce lantibiotics, genetically encoded and posttranslationally modified peptide antibiotics, which inhibit the growth of other Gram-positive bacteria. To protect themselves against their own lantibiotics these bacteria express a variety of immunity proteins including the LanI lipoproteins. The structural and mechanistic basis for LanI-mediated lantibiotic immunity is not yet understood. Lactococcus lactis produces the lantibiotic nisin, which is widely used as a food preservative. Its LanI protein NisI provides immunity against nisin but not against structurally very similar lantibiotics from other species such as subtilin from Bacillus subtilis. To understand the structural basis for LanI-mediated immunity and their specificity we investigated the structure of NisI. We found that NisI is a two-domain protein. Surprisingly, each of the two NisI domains has the same structure as the LanI protein from B. subtilis, SpaI, despite the lack of significant sequence homology. The two NisI domains and SpaI differ strongly in their surface properties and function. Additionally, SpaI-mediated lantibiotic immunity depends on the presence of a basic unstructured N-terminal region that tethers SpaI to the membrane. Such a region is absent from NisI. Instead, the N-terminal domain of NisI interacts with membranes but not with nisin. In contrast, the C-terminal domain specifically binds nisin and modulates the membrane affinity of the N-terminal domain. Thus, our results reveal an unexpected structural relationship between NisI and SpaI and shed light on the structural basis for LanI mediated lantibiotic immunity.

  18. Lantibiotic immunity: inhibition of nisin mediated pore formation by NisI.

    Directory of Open Access Journals (Sweden)

    Zainab AlKhatib

    Full Text Available Nisin, a 3.4 kDa antimicrobial peptide produced by some Lactococcus lactis strains is the most prominent member of the lantibiotic family. Nisin can inhibit cell growth and penetrates the target Gram-positive bacterial membrane by binding to Lipid II, an essential cell wall synthesis precursor. The assembled nisin-Lipid II complex forms pores in the target membrane. To gain immunity against its own-produced nisin, Lactococcus lactis is expressing two immunity protein systems, NisI and NisFEG. Here, we show that the NisI expressing strain displays an IC50 of 73 ± 10 nM, an 8-10-fold increase when compared to the non-expressing sensitive strain. When the nisin concentration is raised above 70 nM, the cells expressing full-length NisI stop growing rather than being killed. NisI is inhibiting nisin mediated pore formation, even at nisin concentrations up to 1 µM. This effect is induced by the C-terminus of NisI that protects Lipid II. Its deletion showed pore formation again. The expression of NisI in combination with externally added nisin mediates an elongation of the chain length of the Lactococcus lactis cocci. While the sensitive strain cell-chains consist mainly of two cells, the NisI expressing cells display a length of up to 20 cells. Both results shed light on the immunity of lantibiotic producer strains, and their survival in high levels of their own lantibiotic in the habitat.

  19. Lantibiotic immunity: inhibition of nisin mediated pore formation by NisI.

    Science.gov (United States)

    AlKhatib, Zainab; Lagedroste, Marcel; Fey, Iris; Kleinschrodt, Diana; Abts, André; Smits, Sander H J

    2014-01-01

    Nisin, a 3.4 kDa antimicrobial peptide produced by some Lactococcus lactis strains is the most prominent member of the lantibiotic family. Nisin can inhibit cell growth and penetrates the target Gram-positive bacterial membrane by binding to Lipid II, an essential cell wall synthesis precursor. The assembled nisin-Lipid II complex forms pores in the target membrane. To gain immunity against its own-produced nisin, Lactococcus lactis is expressing two immunity protein systems, NisI and NisFEG. Here, we show that the NisI expressing strain displays an IC50 of 73 ± 10 nM, an 8-10-fold increase when compared to the non-expressing sensitive strain. When the nisin concentration is raised above 70 nM, the cells expressing full-length NisI stop growing rather than being killed. NisI is inhibiting nisin mediated pore formation, even at nisin concentrations up to 1 µM. This effect is induced by the C-terminus of NisI that protects Lipid II. Its deletion showed pore formation again. The expression of NisI in combination with externally added nisin mediates an elongation of the chain length of the Lactococcus lactis cocci. While the sensitive strain cell-chains consist mainly of two cells, the NisI expressing cells display a length of up to 20 cells. Both results shed light on the immunity of lantibiotic producer strains, and their survival in high levels of their own lantibiotic in the habitat.

  20. [Comparative analysis of activity of different promoters for NIS gene expression in melanoma cells].

    Science.gov (United States)

    Kuz'mich, A I; Kopantsev, E P; Vinogradova, T V; Sverdlov, E D

    2014-01-01

    Development of targeted drug delivery system is key problem of cancer gene therapy. To ensure specific delivery of these therapeutic compounds to the tumor it is preferable for therapeutic gene expression to occur predominantly in cancer cells. Therefore, when testing drug in vivo, it is necessary to study distribution of therapeutic gene expression products in different tissues of the organism. Sodium iodide symporter (NIS) is attractive reporter because its tissue level is easily quantitatively detected by noninvasive imaging methods. Different promoters are used to direct expression of therapeutic genes in tumor cells: strong nonspecific, moderate tissue-specific and tumor-specific. Tumor-specific promoters function in wide range of tumor cells, however they are relatively weak. Relationship between promoter and sodium iodide symporter activity is unclear to date. In this report we examined activity of different promoters in two melanoma cell lines, functional activity of NIS driven by these promoters, also we compared promoter strength and NIS activity. We demonstrated that in spite of strong differences in promoter activity functional activity of NIS directed by these promoters varies weakly. Relatively weak melanoma-specific promoter directs high NIS activity in melanoma cell, however weaker cancer-specific promoters drive high NIS activity only in certain melanoma cell line.

  1. Human sodium iodide symporter (hNIS) in fibroadenoma breast--a immunohistochemical study.

    Science.gov (United States)

    Rai, Ruchi; Shrivastava, Ashutosh; Tandon, Ashwani; Godbole, Madan M; Kumar, Sandeep; Das, Vinita; Dwivedi, Varsha; Pal, Lily

    2011-02-01

    Human sodium iodide symporter (hNIS), responsible for the active transport of iodine is an integral plasma membrane glycoprotein present in the thyroid cells and extrathyroid tissues like breast and salivary glands. If its functional form is unequivocally shown in benign or malignant breast tissues, then it may serve as a basis for diagnosis and treatment using radioactive iodine. With an aim to analyze the hNIS expression in a distinct benign breast condition of fibroadenoma, biopsy proven fibroadenoma tissues, normal non-lactating breast tissue and biopsy proven infiltrating duct carcinoma tissues were examined for hNIS expression using immunohistochemistry. Out of 20 biopsy proven fibroadenoma tissues, 19 (95%) showed positivity for hNIS protein and only one was negative. Of these 10% were mildly positive, 50% cases were moderately positive and 35% showed intense positivity. None of the control tissue obtained from reduction mammoplasty specimens or normal breast tissues samples (5 cms away from the tumor) were positive, hNIS was also intensely positive in 9 out of 10 (90%) infiltrating duct carcinoma tissues and moderately positive in one case. These preliminary results show that hNIS was present in high frequency as demonstrated by immunohistochemistry in fibroadenoma breast.

  2. The potential of {sup 211}Astatine for NIS-mediated radionuclide therapy in prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Willhauck, Michael J.; Sharif Samani, Bibi-Rana; Goeke, Burkhard [Ludwig-Maximilians-University, Department of Internal Medicine II, Munich (Germany); Wolf, Ingo; Senekowitsch-Schmidtke, Reingard [Technische Universitaet Muenchen, Department of Nuclear Medicine, Munich (Germany); Stark, Hans-Juergen [German Cancer Research Center, Department of Carcinogenesis of the Skin, Heidelberg (Germany); Meyer, Geerd J.; Knapp, Wolfram H. [Medizinische Hochschule Hannover, Department of Nuclear Medicine, Hannover (Germany); Morris, John C. [Mayo Clinic College of Medicine, Division of Endocrinology, Rochester, MN (United States); Spitzweg, Christine [Ludwig-Maximilians-University, Department of Internal Medicine II, Munich (Germany); Klinikum Grosshadern, Medizinische Klinik II, Munich (Germany)

    2008-07-15

    We reported recently the induction of selective iodide uptake in prostate cancer cells (LNCaP) by prostate-specific antigen (PSA) promoter-directed sodium iodide symporter (NIS) expression that allowed a significant therapeutic effect of {sup 131}I. In the current study, we studied the potential of the high-energy alpha-emitter {sup 211}At, also transported by NIS, as an alternative radionuclide after NIS gene transfer in tumors with limited therapeutic efficacy of {sup 131}I due to rapid iodide efflux. We investigated uptake and therapeutic efficacy of {sup 211}At in LNCaP cells stably expressing NIS under the control of the PSA promoter (NP-1) in vitro and in vivo. NP-1 cells concentrated {sup 211}At in a perchlorate-sensitive manner, which allowed a dramatic therapeutic effect in vitro. After intrapertoneal injection of {sup 211}At (1 MBq), NP-1 tumors accumulated approximately 16% ID/g {sup 211}At (effective half-life 4.6 h), which resulted in a tumor-absorbed dose of 1,580 {+-} 345 mGy/MBq and a significant tumor volume reduction of up to 82 {+-} 19%, while control tumors continued their growth exponentially. A significant therapeutic effect of {sup 211}At has been demonstrated in prostate cancer after PSA promoter-directed NIS gene transfer in vitro and in vivo suggesting a potential role for {sup 211}At as an attractive alternative radioisotope for NIS-targeted radionuclide therapy, in particular in smaller tumors with limited radionuclide retention time. (orig.)

  3. Reconsidering the magnetic structure in NiS2-xSex

    Science.gov (United States)

    Yano, Shinichiro; Louca, Despina; Chatterjee, Utpal; Chung, Duck Young; Bugaris, Daniel E.; Kanatzidis, Mercouri; Neuefeind, Joerg C.; Feygenson, Mikhail

    2014-03-01

    The Mott metal-insulator transition (MIT) has been at the forefront of condensed matter research for decades. A Mott insulator is associated with antiferromagnetism (AFM) as well as an energy gap. The AFM order parameter can be directly traced by neutron scattering measurements. We focused on the study of MIT on the NiS2-2xSex system. With increase in x where x corresponds to the atomic volume of S that is replaced by Se, the system undergoes an AFM insulator to an AFM metalic transition at x = 0 . 43 at T = 0 . Although NiS2-2xSex has been previously studied, the magnetic structure is not well understood. We measured the powder neutron diffraction for 4 compositions, x = 0, 0.4, 0.6, and 0.8, as a function of temperature. At T = 2K, we observed a clear composition dependence of the magnetic structure. While NiS2 (x = 0) has two magnetic propagation vectors, M1 = (000) and M2 = (0.5 0.5 0.5), NiS1.6Se0.4 and NiS1.4Se0.6 have only one magnetic phase, M1. However, the M1 structure vanishes by NiS1.2Se0.8. While the two magnetic phases have been previously reported, we determined the magnetic structures by using representation analysis.the magnetic structure and physical properties of this system will be discussed.

  4. Au-controlled enhancement of photoluminescence of NiS nanostructures synthesized via a microwave-assisted hydrothermal technique

    CSIR Research Space (South Africa)

    Linganiso, EC

    2014-11-01

    Full Text Available Nickel sulphide (NiS) nanostructures decorated with gold (Au) nanoparticles (NPs) were synthesized via a microwave-assisted hydrothermal technique. Binary phase NiS (a and ß) crystalline nanostructures, bare, and decorated with Au NPs were obtained...

  5. Towards a biochemical and structural characterisation of the sodium-iodide sym-porter (Nis)

    Energy Technology Data Exchange (ETDEWEB)

    Darrouzet, E.; Marcellin, D.; Huc, S.; Quemeneur, E. [CEA Centre de Marcoule (SBTN), 30 - Bagnols-sur-Ceze (France); Pourcher, T. [Nice Univ., TIRO CEA, Sophia Antipolis, 06 - Nice (France)

    2006-07-01

    Iodide is essential for thyroid hormone biosynthesis in mammals, and therefore for the control of cell metabolism and the development of the central nervous system in the foetus and newborns, but is relatively scarce element in the environment. To ensure its accumulation, the thyroid gland has evolved a remarkably efficient system, the sodium-iodide sym-porter (NIS), that was first characterized at the molecular level 10 years ago (1). NIS is an intrinsic protein mainly located in the basolateral membrane of thyroid follicular cells where it actively transports iodide ions using the sodium gradient as a driving force (2,3). In addition, this transporter has been found in lactating mammary gland, stomach, and salivary glands, and its mRNA was detected in brain, ovaries, testis. To date, the physiological role of NIS in these organs is not yet identified (3,4).The capacity of NIS to mediate the accumulation of radioactive iodide has been exploited for many years in the diagnosis of thyroid cancer as well as for the detection and radiotherapy of derived metastases. Moreover, the presence of NIS in some breast tumours and the possibility to express it by targeted gene therapy in tumour cells where it is not naturally present could also widen its medical application (4-7). In case of accidental contamination, NIS would also be responsible for accumulation of radioisotopes in the thyroid and for their transfer to the milk and the newborn, eventually causing thyroid cancers. This has motivated our research program in the perspective of designing novel specific therapeutics. During the last decade, the gene encoding the thyroid NIS has been identified and sequenced in various species including rat, mouse and human (1, 8). It was also demonstrated that the protein expression and activity are highly regulated both at the transcriptional and post-translational levels (3). A preliminary topological mode could be drawn from the protein sequence. It proposes a general

  6. Au-controlled enhancement of photoluminescence of NiS nanostructures synthesized via a microwave-assisted hydrothermal technique

    Energy Technology Data Exchange (ETDEWEB)

    Linganiso, Ella Cebisa [DST/CSIR Nanotech Innovation Centre, National Centre for Nano-structured Materials, Council for Scientific and Industrial Research, PO Box 395, Pretoria 0001 (South Africa); Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, Wits, 2050 Johannesburg (South Africa); Mwakikunga, Bonex Wakufwa, E-mail: bmwakikunga@csir.co.za [DST/CSIR Nanotech Innovation Centre, National Centre for Nano-structured Materials, Council for Scientific and Industrial Research, PO Box 395, Pretoria 0001 (South Africa); Department of Physics and Biochemical Sciences, The Polytechnic of the University of Malawi, Private Bag 303, Chichiri, Blantyre 0003 (Malawi); Mhlanga, Sabelo Dalton [Department of Applied Chemistry, University of Johannesburg, PO Box 17011, Doornfontein, 2028 Johannesburg (South Africa); Coville, Neil John [Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, Wits, 2050 Johannesburg (South Africa); DST/NRF Centre of Excellence in Strong Materials, University of the Witwatersrand, Private Bag 3, Wits, 2050 Johannesburg (South Africa)

    2014-11-15

    Nickel sulphide (NiS) nanostructures decorated with gold (Au) nanoparticles (NPs) were synthesized via a microwave-assisted hydrothermal technique. Binary phase NiS (α and β) crystalline nanostructures, bare, and decorated with Au NPs were obtained and confirmed by X-ray diffraction (XRD) studies. TEM analysis revealed that the NiS nanostructures were of various shapes. A quantum confinement effect was confirmed by the blue shift PL emissions and high optical energy band gap observed for the as-synthesized sample. A threefold light emission enhancement due to Au NP coatings was obtained when Au metal NP decoration concentrations was varied from 1% to 10%. These enhancements were attributed to the surface plasmon resonance (SPR) excitation of the surface decorated metal NPs which results in an increased rate of spontaneous emission. The PL enhancement factor was observed to vary at different NiS emissions as well as with the size of the Au NPs. The effect of metal NP decoration on the PL emission of NiS is to the best of our knowledge, presented for the first time. - Highlights: • Binary phase NiS decorated with gold nanoparticles. • Quantum confinement effect confirmed by PL analysis. • PL enhancement depending more on particle size distribution. • Effect of gold on NiS PL is to the best of our knowledge reported for the first time.

  7. [Baltisches Welterlebnis. Die kulturgeschichtliche Bedeutung von Alexander, Eduard und Hermann Graf Keyserling. Beiträge eines internationalen Symposium in Tartu vom 19. bis 21. September 2003

    Index Scriptorium Estoniae

    Garleff, Michael, 1940-

    2011-01-01

    Baltisches Welterlebnis. Die kulturgeschichtliche Bedeutung von Alexander, Eduard und Hermann Graf Keyserling. Beiträge eines internationalen Symposium in Tartu vom 19. bis 21. September 2003. Heidelberg : Universitätsverlag Winter, 2007

  8. Navigating the maze of requirements for obtaining approval of non-interventional studies (NIS) in the European Union.

    Science.gov (United States)

    Ramirez, Isabelle

    2015-01-01

    The purpose of this article is to give an overview of the complexities and unexpected regulatory requirements for obtaining approval of multinational and multicentre non-interventional studies (NIS) in the European Union (EU). The websites of national competent authorities (CAs), ethics committees (ECs) and data protection (DP) authorities were consulted to find regulations and guidance information related to the authorisation of NIS in various member states of the EU. Many additional hurdles, neither disclosed nor clear in the various regulations/guidances for NIS, were identified. Although approval from the CA is not needed for NIS, in many countries request of CA opinion is nevertheless recommended, prior to submission to the EC, to obtain confirmation that the planned NIS does not fall in the interventional trial category. Clinical trial insurance was required in some countries. In countries like Belgium and Italy, the multicentre NIS required the approval from a central EC and local ECs as a single central EC opinion was not considered sufficient. The EC document requirements for submission and the fees were extremely variable among all member states. Additional approvals from data protection authorities and insurance companies were required in some countries. The process of obtaining approval for multicentre and multinational NIS is time consuming due to lack of transparency and the different regulatory requirements among member states. The EU pharmacovigilance legislation and clinical trial regulation No 536/2014 is a step forward in providing a regulatory framework for PASS (post-authorisation safety studies) and low intervention clinical trials, but since regulation No 536/2014 excludes NIS, it will be difficult to enforce harmonization of requirements for approval of NIS among member states.

  9. MPC&A training needs of the NIS/Baltics States.

    Energy Technology Data Exchange (ETDEWEB)

    Beck, David Franklin; Stoy-McLeod, Carol L.

    2006-07-01

    This report serves to document contract deliverables considered to be of continuing interest associated with two workshops conducted as part of an initial assessment of Material Protection, Control, and Accounting (MPC&A) training needs of the Newly Independent and Baltic States (NIS/Baltics). These workshops were held in Kiev, Ukraine, ca. 2003-2004, with the assistance of personnel from the George Kuzmycz Training Center (GKTC) of the Kiev Institute of Nuclear Research (KINR). Because of the dominant role Ukraine plays in the region in terms of the nuclear industry, one workshop focused exclusively on Ukrainian training needs, with participants attending from twelve Ukrainian organizations (plus U.S. DOE/NNSA representatives). The second workshop included participation by a further ten countries from the NIS/Baltics region. In addition, the training needs data developed during the workshop were supplemented by the outcomes of surveys and studies conducted by the GKTC.

  10. SPECT Imaging for in vivo tracking of NIS containing stem cells

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Zhenghong

    2013-04-02

    Na+/I- symporter (NIS) gene as a reporter gene (imagene) for non-invasive imaging of infused stem cells distribution and persistence in vivo on small animal models. NIS is an intrinsic membrane glycoprotein that mediates active iodide (I-) uptake into normal thyroid follicular cells and other cells. The advantages of using NIS for non-invasive and repeated scintigraphic imaging in this application are: a) NIS is not a foreign gene and thus eliminate the immunoresponse problem; b) radiotracer or substrate for NIS is simply radioiodide (I-125, I- 123, I-124, and I-124) or [Tc-99m]-pertechnetate, no radiosynthesis is needed. It has been shown that NIS gene transfer can induce radioactive iodide uptake in a variety of cells and that xenografts expressing exogenous NIS could be imaged by non-invasive scintigraphic imaging. The specific aims are: 1.Determine the feasibility, stability and physiological effects of human NIS gene expression on human HSCs and MSCs in vitro. 2.Determine the engraftment of human HSC and MSC co-infused in NOD-SCID mice. 3.Transduce both a drug resistance gene and an imagene into bone marrow stem cells, and follow the dynamics of engraftment after selection in real time.

  11. A Robust Cooling Platform for NIS Junction Refrigeration and sub-Kelvin Cryogenic Systems

    Science.gov (United States)

    Wilson, B.; Atlas, M.; Lowell, P.; Moyerman, S.; Stebor, N.; Ullom, J.; Keating, B.

    2014-08-01

    Recent advances in Normal metal-insulator-superconductor (NIS) tunnel junctions (Clark et al. Appl Phys Lett 86: 173508, 2005, Appl Phys Lett 84: 4, 2004) have proven these devices to be a viable technology for sub-Kelvin refrigeration. NIS junction coolers, coupled to a separate cold stage, provide a flexible platform for cooling a wide range of user-supplied payloads. Recently, a stage was cooled from 290 to 256 mK (Lowell et al. Appl Phys Lett 102: 082601 2013), but further mechanical and electrical improvements are necessary for the stage to reach its full potential. We have designed and built a new Kevlar suspended cooling platform for NIS junction refrigeration that is both lightweight and well thermally isolated; the calculated parasitic loading is pW from 300 to 100 mK. The platform is structurally rigid with a measured deflection of 25 m under a 2.5 kg load and has an integrated mechanical heat switch driven by a superconducting stepper motor with thermal conductivity G W/K at 300 mK. An integrated radiation shield limits thermal loading and a modular platform accommodates enough junctions to provide nanowatts of continuous cooling power. The compact stage size of 7.6 cm 8.6 cm 4.8 cm and overall radiation shield size of 8.9 cm 10.0 cm 7.0 cm along with minimal electrical power requirements allow easy integration into a range of cryostats. We present the design, construction, and performance of this cooling platform as well as projections for coupling to arrays of NIS junctions and other future applications.

  12. Feasibility of a novel positive feedback effect of {sup 131}I-promoted Bac-Egr1-hNIS expression in malignant glioma via baculovirus

    Energy Technology Data Exchange (ETDEWEB)

    Guo Rui [Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025 (China); Tian Lipeng [Department of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025 (China); Han Bing [Department of Endocrine, The 9th Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025 (China); Xu Haoping; Zhang Miao [Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025 (China); Li Biao, E-mail: lb10363@rjh.com.c [Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025 (China)

    2011-05-15

    Purpose: As intracellular iodine is released rapidly, increased expression of sodium/iodide symporter (NIS) is required for effective radioiodine treatment of tumor. As Egr1 promoter is activated by {sup 131}I and may promote human NIS (hNIS) expression, hNIS also induces {sup 131}I uptake and activates Egr1, so the existence of a positive feedback effect of {sup 131}I-promoted Egr1-hNIS expression is possible. Our purpose was to investigate the possible existence of this positive feedback effect through a series of in vitro pioneer studies. Method: Recombinant baculovirus (Bac-Egr1-hNIS) encoding the hNIS gene under the control of a radiation-inducible Egrl promoter was constructed. To test {sup 131}I-promoted hNIS expression, human malignant glioma U87 cells were transfected with Bac-Egr1-hNIS, stimulated with or without {sup 131}I; the expression of hNIS protein was detected by immunofluorescence and flow cytometry test. In addition, the uptake and efflux of {sup 131}I were determined after the incubation of Bac-Egr1-hNIS-transfected U87 cells with or without {sup 131}I. Results: Immunocytochemical staining and flow cytometry test showed a higher hNIS protein expression in Bac-Egr1-hNIS-transfected U87 cells with {sup 131}I stimulation than in cells without stimulation. Bac-Egr1-hNIS-transfected U87 cells accumulated up to about 4.05 times of {sup 131}I after {sup 131}I stimulation. The amount of {sup 131}I uptake in both groups showed a baculovirus dose-dependent manner. However, rapid efflux of radioactivity was observed in both groups, with 50% lost during the first 2 min after the {sup 131}I-containing medium had been replaced by a nonradioactive medium. Conclusion: Our results indicated that an improved transgene expression of {sup 131}I-stimulated hNIS in U87 cells using a baculovirus vector containing the Egr1 promoter is possible, and the increased expression of hNIS is responsible for a higher {sup 131}I uptake. It might provide a reference for the

  13. The relevance of the historical dimension of hydropower; Zur Bedeutung der historischen Dimension der Wasserkraft

    Energy Technology Data Exchange (ETDEWEB)

    Aicher, J.

    2000-04-01

    Hydropower has played an important role throughout the past two millennia. It is therefore conceivable that this potential source of energy could again come much more to the forefront today. This is illustrated by examples of the successful reactivation of old hydropower facilities. Furthermore, the paper points out the significance of hydropower for craft and trade during the Middle Ages, for the monastic culture and existing landscape features and for the industrialization that took place in Southern Germany during the 19{sup th} century. Finally, the early days of electricity generation using hydropower are recalled. (orig.) [German] Der Verfasser macht deutlich, dass vielfache historische Quellen auf eine kuenftig moegliche, wesentlich staerkere Nutzung der Wasserkraft hindeuten. Beispielhaft berichtet er von messbaren Erfolgen bei der Wieder-Aktivierung alter Wasserkraftanlagen. Ausserdem wird die Bedeutung der Wasserkraft fuer das Gewerbe im Mittelalter, fuer erhaltene Klosterkultur und Landschaft sowie auf die Industrialisierung mit Wasserkraft im Sueddeutschland des 19. Jahrhunderts hingewiesen. Zum Schluss erinnert der Autor an die Anfaenge der Stromversorgung mit Wasserkraft. (orig.)

  14. Determination of major sodium iodide symporter (NIS) inhibitors in drinking waters using ion chromatography with conductivity detector.

    Science.gov (United States)

    Cengiz, Mehmet Fatih; Bilgin, Ayse Kevser

    2016-02-20

    Goiter is an important health problem all over the world and iodine deficiency is its most common cause. Perchlorate, thiocyanate and nitrate (called as major NIS inhibitors) are known to competitively inhibit iodide uptake by the thyroid gland and thus, human exposure to major NIS inhibitors is a public health concern. In this study, an ion chromatographic method for the determination of most common NIS inhibitor ions in drinking waters was developed and validated. This is the first study where an analytical method is used for the determination of major NIS inhibitors in drinking water by an ion chromatography system in a single run. Chromatographic separations were achieved with an anion-exchange column and separated ions were identified by a conductivity detector. The method was found to be selective, linear, precise accurate and true for all of interested ions. The limits of the detections (LOD) were estimated at 0.003, 0.004 and 0.025mgL(-1) for perchlorate, thiocyanate and nitrate, respectively. Possible interference ions in drinking waters were examined for the best separation of NIS inhibitors. The excellent method validation data and proficiency test result (Z-score for nitrate: -0.1) of the FAPAS(®) suggested that the developed method could be applied for determination of NIS inhibitor residues in drinking waters. To evaluate the usefulness of the method, 75 drinking water samples from Antalya/Turkey were analyzed for NIS inhibitors. Perchlorate concentrations in the samples ranged from not detected (less than LOD) to 0.07±0.02mgL(-1) and the range of nitrate concentrations were found to be 3.60±0.01mgL(-1) and 47.42±0.40mgL(-1). No thiocyanate residues were detected in tested drinking water samples.

  15. "Bomb explosion on the Nis express" - lessons from a major incident, Kosovo 16 Feb 2001.

    Science.gov (United States)

    Vassallo, D J; Graham, P J K; Gupta, G; Alempijevic, Dj

    2005-03-01

    On Friday 16 February 2001, terrorists detonated a bomb under a civilian coach travelling from Nis in Serbia to Gracanica in Kosovo. 10 people were killed at the scene. 13 casualties were treated in the British KFOR hospital (Reynolds Hospital) in Pristina. Another 8 casualties were evacuated to the American KFOR hospital at Camp Bondsteel. The incident provided a unique opportunity for co-operation between British, American, Russian, German and French KFOR hospitals, as well as with Serbian clinicians and forensic pathologists. This article analyses the medical management of this major incident, identifies the lessons to be learned from it, and also provides enough detail for teaching scenarios.

  16. Reduced graphene oxide-induced recrystallization of NiS nanorods to nanosheets and the improved Na-storage properties.

    Science.gov (United States)

    Pan, Qin; Xie, Jian; Zhu, Tiejun; Cao, Gaoshao; Zhao, Xinbing; Zhang, Shichao

    2014-04-07

    Preparation of two-dimensional (2D) graphene-like materials is currently an emerging field in materials science since the discovery of single-atom-thick graphene prepared by mechanical cleavage. In this work, we proposed a new method to prepare 2D NiS, where reduced graphene oxide (rGO) was found to induce the recrystallization of NiS from nanorods to nanosheets in a hydrothermal process. The process and mechanism of recrystallization have been clarified by various characterization techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDS) mapping, and X-ray photoelectron spectroscopy (XPS). The characterization of ex situ NiS/rGO products by SEM and EDS mapping indicates that the recrystallization of NiS from nanorods to nanosheets is realized actually through an exfoliation process, while the characterization of in situ NiS/rGO products by SEM, TEM, and EDS mapping reveals the exfoliation process. The XPS result demonstrates that hydrothermally assisted chemical bonding occurs between NiS and rGO, which induces the exfoliation of NiS nanorods into nanosheets. The obtained NiS/rGO composite shows promising Na-storage properties.

  17. Increase of Fungal Pathogenicity and Role of Plant Glutamine in Nitrogen-Induced Susceptibility (NIS) To Rice Blast

    Science.gov (United States)

    Huang, Huichuan; Nguyen Thi Thu, Thuy; He, Xiahong; Gravot, Antoine; Bernillon, Stéphane; Ballini, Elsa; Morel, Jean-Benoit

    2017-01-01

    Highlight  Modifications in glutamine synthetase OsGS1-2 expression and fungal pathogenicity underlie nitrogen-induced susceptibility to rice blast. Understanding why nitrogen fertilization increase the impact of many plant diseases is of major importance. The interaction between Magnaporthe oryzae and rice was used as a model for analyzing the molecular mechanisms underlying Nitrogen-Induced Susceptibility (NIS). We show that our experimental system in which nitrogen supply strongly affects rice blast susceptibility only slightly affects plant growth. In order to get insights into the mechanisms of NIS, we conducted a dual RNA-seq experiment on rice infected tissues under two nitrogen fertilization regimes. On the one hand, we show that enhanced susceptibility was visible despite an over-induction of defense gene expression by infection under high nitrogen regime. On the other hand, the fungus expressed to high levels effectors and pathogenicity-related genes in plants under high nitrogen regime. We propose that in plants supplied with elevated nitrogen fertilization, the observed enhanced induction of plant defense is over-passed by an increase in the expression of the fungal pathogenicity program, thus leading to enhanced susceptibility. Moreover, some rice genes implicated in nitrogen recycling were highly induced during NIS. We further demonstrate that the OsGS1-2 glutamine synthetase gene enhances plant resistance to M. oryzae and abolishes NIS and pinpoint glutamine as a potential key nutrient during NIS. PMID:28293247

  18. Increased expression of AP2 and Sp1 transcription factors in human thyroid tumors: a role in NIS expression regulation?

    Directory of Open Access Journals (Sweden)

    Schlumberger Martin

    2002-12-01

    Full Text Available Abstract Background Sodium/iodide symporter (NIS is a key protein in iodide transport by thyroid cells and this activity is a prerequisite for effective radioiodide treatment of thyroid cancer. In the majority of thyroid cancers, however, iodide uptake is reduced, probably as a result of decreased NIS protein expression. Methods To identify the mechanisms that negatively affect NIS expression in thyroid tumors, we performed electrophoresis mobility shift assays and immunoblot analysis of nuclear protein extracts from normal and tumoral thyroid tissues from 14 unrelated patients. Results Two proteins closely related to the transcription factors AP2 and Sp1 were identified in the nuclear extracts. Expression of both AP2 and Sp1 in nuclear extracts from thyroid tumors was significantly higher than that observed in corresponding normal tissues. Conclusion These observations raise the possibility that NIS expression, and subsequently iodide transport, are reduced in thyroid tumors at least in part owing to alterations in the binding activity of AP2 and Sp1 transcription factors to NIS promoter.

  19. Iodide transporter NIS regulates cancer cell motility and invasiveness by interacting with the Rho guanine nucleotide exchange factor LARG.

    Science.gov (United States)

    Lacoste, Claire; Hervé, Julie; Bou Nader, Myriam; Dos Santos, Alexandre; Moniaux, Nicolas; Valogne, Yannick; Montjean, Rodrick; Dorseuil, Olivier; Samuel, Didier; Cassio, Doris; Portulano, Carla; Carrasco, Nancy; Bréchot, Christian; Faivre, Jamila

    2012-11-01

    A number of solute carrier (SLC) proteins are subject to changes in expression and activity during carcinogenesis. Whether these changes play a role in carcinogenesis is unclear, except for some nutrients and ion carriers whose deregulation ensures the necessary reprogramming of energy metabolism in cancer cells. In this study, we investigated the functional role in tumor progression of the sodium/iodide symporter (NIS; aka SLC5A5), which is upregulated and mislocalized in many human carcinomas. Notably, we found that NIS enhanced cell migration and invasion without ion transport being involved. These functions were mediated by NIS binding to leukemia-associated RhoA guanine exchange factor, a Rho guanine exchange factor that activates the small GTPase RhoA. Sequestering NIS in intracellular organelles or impairing its targeting to the cell surface (as observed in many cancers) led to a further increase in cell motility and invasiveness. In sum, our results established NIS as a carrier protein that interacts with a major cell signaling hub to facilitate tumor cell locomotion and invasion.

  20. Wie entsteht Bedeutung in der präverbalen Entwicklungsphase des Kleinkindes? Analyse kognitions- und neurowissenschaftlicher Erkenntnisse zur Bildung einer Theorie der Bedeutungsentwicklung

    OpenAIRE

    Damen, Sonja

    2013-01-01

    Die Arbeit stellt heraus, dass Bedeutung der „biologische“ Wert (Damasio 2011) allen Lebens ist. Ohne Interpretation der umgebenden Umwelt ist kein Lebewesen lebensfähig. In der präverbalen Entwicklung des Kindes schlägt das „emotionale Signalisieren“ (Greenspan/Shanker 2007) die Brücke zum „kulturellen Wert“, ohne den keine Entwicklung stattfinden würde. Bedeutung entsteht demnach nur in der sozialen Bezogenheit, in der dem Kind die emotionale Kontextgebundenheit Handlungsbedeutungen eröffne...

  1. Materijalna motivacija kao nosilac uspešne reorganizacije kompanije NIS (Material Motivation as the Holder of a Successful Reorganization on the Example of Company Nis

    Directory of Open Access Journals (Sweden)

    Radmila Stojanović

    2015-04-01

    Full Text Available For successful organization people are the primary development resource. Motivation and satisfaction of employees become the basis of modern organizations. Motivated employees today represent a strategic resource which gain a competitive advantage for the organization. If someone wants to motivate others, must first be able to motivate yourself. That means that if in organization exists motivated staff, there must be a motivated manager who will be able to launch employees. The aim of this paper is to emphasizes the importance of material motivation for successful business of a large company that had in the past significant organizational change. Through unstructured interviews were collected data on which was investigated the hypothesis that the material motivation of the most important holder for successful reorganization on the example of leading Serbian company for exploration, production and refining of oil and gas NIS. From the above it can be concluded that high-quality human resources management involves proper motivation system, that has been based on material incentives. In this paper, attention will be focused on monetary motivation and how a well-established system of material incentives can lead to the great success of the company that had a significant reorganization in the past. It will be shown in detail the system of material incentives and the positive results which obtained by this system, when it comes to the business of the company, which today is the most desirable employer in Serbia and the region. The paper should emphasize the benefits of a fair system of motivation which brings to an organization, but also to encourage further thinking to improve this aspect of motivation, which is a prerequisite for successful business and the basis for all other activities in the HRM. The analysis results indeed show that a system of material incentives in NIS is the holder of a successful reorganization, and the proof is the business

  2. Dielectric relaxation studies on two-dimensional nanocomposites of NiS and Na-4 mica

    Science.gov (United States)

    Bose, A.; Mandal, A.; Mitra, S.; De, S. K.; Banerjee, S.; Chakravorty, D.

    2013-10-01

    Na-4 mica template has been used to grow NiS nanosheets within the nanochannels with thickness 0.6 nm. DC and ac electrical properties of the nanocomposite in a pellet-form have been measured over temperature range 313-473 K at frequencies from 102 to 106 Hz. The dc resistivity variation as a function of temperature has been explained as arising due to a parallel combination of NiS nanosheets and Na-4 mica grains. The activation energies of conduction have been found to be 0.23 and 0.45 eV in temperature ranges 323-363 K and 363-424 K, respectively. The frequency exponent s obtained from ac data has a value 0.7 which signifies a three-dimensional movement of the charge carriers involved. The dielectric modulus has been analyzed by two phase laminar conductor model proposed by Isard. The activation energies of dc resistivity and relaxation time are in reasonable agreement with each other in the different temperature ranges measured.

  3. A charge self-consistent LDA+DMFT study of the spectral properties of hexagonal NiS

    Science.gov (United States)

    Panda, S. K.; Thunström, P.; Di Marco, I.; Schött, J.; Delin, A.; Dasgupta, I.; Eriksson, O.; Sarma, D. D.

    2014-09-01

    The electronic structure and spectral properties of hexagonal NiS have been studied in the high temperature paramagnetic phase and low temperature antiferromagnetic phase. The calculations have been performed using charge self-consistent density-functional theory in local density approximation combined with dynamical mean-field theory (LDA+DMFT). The photoemission spectra (PES) and optical properties have been computed and compared with the experimental data. Our results show that the dynamical correlation effects are important to understand the spectral and optical properties of NiS. These effects have been analyzed in detail by means of the computed real and imaginary part of the self-energy.

  4. The E-NIS instrument on-board the ESA Euclid Dark Energy Mission: a general view after positive conclusion of the assesment phase

    NARCIS (Netherlands)

    Valenziano, L.; Zerbi, F.M.; Cimatti, A.; Bianco, A.; Bonoli, C.; Bortoletto, F.; Bulgarelli, A.; Butler, R.C.; Content, R.; Corcione, L.; Rosa, A.de; Franzetti, P.; Garilli, B.; Gianotti, F.; Giro, E.; Grange, R.; Leutenegger, P.; Ligori, S.; Martin, L.; Mandolesi, N.; Morgante, G.; Nicastro, L.; Riva, M.; Robberto, M.; Sharples, R.; Spanó, P.; Talbot, G.; Trifoglio, M.; Wink, R.; Zamkotsian, F.

    2010-01-01

    The Euclid Near-Infrared Spectrometer (E-NIS) Instrument was conceived as the spectroscopic probe on-board the ESA Dark Energy Mission Euclid. Together with the Euclid Imaging Channel (EIC) in its Visible (VIS) and Near Infrared (NIP) declinations, NIS formed part of the Euclid Mission Concept

  5. The acceleration intermediate phase (NiS and Ni3S2) evolution by nanocrystallization in Li/NiS2 thermal batteries with high specific capacity

    Science.gov (United States)

    Jin, Chuanyu; Zhou, Lingping; Fu, Licai; Zhu, Jiajun; Li, Deyi; Yang, Wulin

    2017-06-01

    The intermediate phase of NiS2 is thought to be a bottleneck currently to improve the overall performance of Li/NiS2 thermal batteries because of its low conductivity and close formation enthalpy between NiS2 and the intermediate phase (NiS, Ni3S2, etc). For improving the discharge performances of Li/NiS2 thermal batteries, the nano NiS2 with an average size of 85 ± 5 nm is designated as a cathode material. The electrochemical measurements show that the specific capacity of nano NiS2 cathode is higher than micro NiS2. The nano NiS2 cathode exhibits excellent electrochemical performances with high specific capacities of 794 and 654 mAh g-1 at current density of 0.1 and 0.5 A cm-2 under a cut-off voltage of 0.5 V, respectively. These results show that the rapid intermediate phase evolution from the nanocrystallization can obviously enhance use efficiency of NiS2 and improve discharge performances of thermal batteries.

  6. The E-NIS instrument on-board the ESA Euclid Dark Energy Mission: a general view after positive conclusion of the assesment phase

    NARCIS (Netherlands)

    Valenziano, L.; Zerbi, F.M.; Cimatti, A.; Bianco, A.; Bonoli, C.; Bortoletto, F.; Bulgarelli, A.; Butler, R.C.; Content, R.; Corcione, L.; Rosa, A.de; Franzetti, P.; Garilli, B.; Gianotti, F.; Giro, E.; Grange, R.; Leutenegger, P.; Ligori, S.; Martin, L.; Mandolesi, N.; Morgante, G.; Nicastro, L.; Riva, M.; Robberto, M.; Sharples, R.; Spanó, P.; Talbot, G.; Trifoglio, M.; Wink, R.; Zamkotsian, F.

    2010-01-01

    The Euclid Near-Infrared Spectrometer (E-NIS) Instrument was conceived as the spectroscopic probe on-board the ESA Dark Energy Mission Euclid. Together with the Euclid Imaging Channel (EIC) in its Visible (VIS) and Near Infrared (NIP) declinations, NIS formed part of the Euclid Mission Concept deriv

  7. In vivo monitoring of transfected DNA, gene expression kinetics, and cellular immune responses in mice immunized with a human NIS gene-expressing plasmid.

    Science.gov (United States)

    Son, Hye-Youn; Jeon, Yong-Hyun; Chung, June-Key; Kim, Chul-Woo

    2016-12-01

    In assessing the effectiveness of DNA vaccines, it is important to monitor: (1) the kinetics of target gene expression in vivo; and (2) the movement of cells that become transfected with the plasmid DNA used in the immunization of a subject. In this study, we used, as a visual imaging marker, expression of the transfected human sodium/iodide symporter (hNIS) gene, which enhances intracellular radio-pertechnetate (TcO4-) accumulation. After intradermal (i.d.) and systemic injection of mice with pcDNA-hNIS and radioactive Technetium-99m (Tc-99m), respectively, whole-body images were obtained by nuclear scintigraphy. The migration of mice cells transfected with the hNIS gene was monitored over a 2-week period by gamma-radioactivity counting of isolated cell populations and was demonstrated in peripheral lymphoid tissues, especially in the draining lymph nodes (dLNs). Beginning at 24 h after DNA inoculation and continuing for the 2-week monitoring period, hNIS-expressing cells were observed specifically in the T-cell-rich zones of the paracortical area of the dLNs. Over the same time period, high levels of INF-γ-secreting CD8 T-cells were found in the dLNs of the pcDNA-hNIS immunized mice. Tumor growth was also significantly retarded in the mice that received hNIS DNA immunization followed by inoculation with CT26 colorectal adenocarcinoma cells that had been transfected with the rat NIS gene (rNIS), which is 93% homologous to the hNIS gene. In conclusion, mouse cells transfected with hNIS DNA after i.d. immunization were found to traffic to the dLNs, and hNIS gene expression in these cells continued for at least 2 weeks post immunization. Furthermore, sequential presentation of NIS DNA to T-cells by migratory antigen presenting cells could induce NIS DNA-specific Th1 immune responses and thus retard the growth of NIS-expressing tumors.

  8. Characterization of the Lactococcus lactis Nisin A Operon Genes nisP, Encoding a Subtilisin-Like Serine Protease Involved in Precursor Processing, and nisR, Encoding a Regulatory Protein Involved in Nisin Biosynthesis

    NARCIS (Netherlands)

    Polman, Joyce; Beerthuyzen, Marke M.; Siezen, Roland J.; Kuipers, Oscar P.; Vos, Willem M. de

    1993-01-01

    Biosynthesis of the lantibiotic peptide nisin by Lactococcus lactis NIZO R5 relies on the presence of the conjugative transposon Tn5276 in the chromosome. A 12-kb DNA fragment of Tn5276 including the nisA gene and about 10 kb of downstream DNA was cloned in L. lactis, resulting in the production of

  9. Nisin A前体基因nisA的过量表达对Nisin A产量的影响%Effect of overexpressing Nisin A structural gene nisA on Nisin A production

    Institute of Scientific and Technical Information of China (English)

    樊苗苗; 邱一敏; 刘晨; 冀志霞; 马昕; 虞沂; 陈守文

    2012-01-01

    Nisin是一种广泛应用于食品工业的抗菌素.通过基因工程手段分别构建了NisinA前体结构基因nisA的穿梭表达载体pMG36ek-nisA和整合型载体pDG780-nisA,并转入Nisin A产生菌乳酸乳球菌Lactococcus lactis ATCC 11454中,得到两株基因工程菌FMM1和FMM2.对比工程菌和原始产生菌的生长状态及Nisin A产量,结果表明FMM1的生长速度、生物量以及发酵液的酸碱度没有显著变化,而NisinA产量提高了31%;相反,FMM2的生物量较原始菌株显著降低,但Nisin A产量也有一定程度的提高.通过RT-PCR检测工程菌与原始产生菌Nisin A生物合成基因簇中11个基因的转录水平,结果显示FMM1和FMM2的11个基因的转录水平均有提高,其中FMM1提高更为显著.因此推测,nisA是NisinA高产的关键因素之一,其游离型过量表达能显著提高Nisin A的产量.该研究为采用基因工程手段提高Nisin A的产量提供了新的思路,并对NisinA的大规模工业生产有指导意义,同时,也为其他抗菌肽产生菌的基因工程改造提供了参考.%Nisin is an antimicrobial peptide widely used in food industry. In this study, Nisin A production in Lactococcus lactis ATCC 11454 was improved by overexpression of Nisin A structural gene nisA through introducing a shuttle expression vector pMG36ek-nisA and an integrated vector pDG780-nisA into the host strain. The differences of growth profiles and Nisin A production level between the two obtained genetic engineering strains FMM1/FMM2 and the parent strain were investigated. Our results show that while the growth profile (the growth rate, biomass and pH) of FMM1 was similar to the parent strain, its Nisin A production increased 31%. In contrast, the biomass of FMM2 was notably lower than the parent strain, while its yield of Nisin A enhanced slightly. The transcription level of genes involved in Nisin A biosynthesis in both engineering strains was further detected by RT-PCR. We found that all

  10. Raman spectroscopy of NiSe2 and NiS2-xSex (0

    Science.gov (United States)

    de las Heras, C.; Agulló-Rueda, F.

    2000-06-01

    The Raman spectra of NiS2-xSex (0NiSe2. The NiSe2 spectrum is qualitatively similar to the spectrum of NiS2, but all frequencies are shifted to lower energies. The shift has been analysed in terms of the increment of the anion mass and the lattice expansion. Peaks in the Raman spectrum of the NiS2-xSex alloy can be assigned to stretching and rotational modes of the S-S, Se-Se and S-Se pairs. The stretching vibration of the S-Se pairs shifts almost linearly from 400 cm-1 for NiS2 to 330 cm-1 for NiSe2. There is an accidental degeneracy between the S-S stretching and Se-Se libration frequencies. The relative Raman intensities fit well with a random occupation of the anion sites by S and Se atoms, and different scattering cross sections.

  11. [Stradiņš, Jānis. Zinātnes un augstskolu sākonte Latvija] / Raimo Pullat

    Index Scriptorium Estoniae

    Pullat, Raimo, 1935-

    2011-01-01

    Arvustus:Stradiņš, Jānis. Zinātnes un augstskolu sākonte Latvija. (Rīga, 2009). J. Stradiņši monograafia on ulatuslik ja sisukas kokkuvõte Läti kultuuri ja teaduse ajaloost kuni 19. sajandi lõppkümnenditeni

  12. Metallic behavior of NiS thin film under the structural, optical, electrical and ab initio investigation frameworks

    Energy Technology Data Exchange (ETDEWEB)

    Boughalmi, R. [Unité de physique des dispositifs à semi-conducteurs, Faculté des sciences de Tunis, Tunis El Manar University, 2092 Tunis (Tunisia); Rahmani, R. [Laboratoire de Physique des Couches Minces et Matériaux pour l' Electronique (LPC2ME). Département de physique, Faculté des Sciences, Université d' Oran Es-Sénia, Oran (Algeria); Département de physique, Université des Sciences et de la Technologie d' Oran- Mohamed-Boudiaf, Oran (Algeria); Boukhachem, A., E-mail: abdelwaheb.boukhachem@laposte.net [Unité de physique des dispositifs à semi-conducteurs, Faculté des sciences de Tunis, Tunis El Manar University, 2092 Tunis (Tunisia); Amrani, B.; Driss-Khodja, K. [Laboratoire de Physique des Couches Minces et Matériaux pour l' Electronique (LPC2ME). Département de physique, Faculté des Sciences, Université d' Oran Es-Sénia, Oran (Algeria); Amlouk, M. [Unité de physique des dispositifs à semi-conducteurs, Faculté des sciences de Tunis, Tunis El Manar University, 2092 Tunis (Tunisia)

    2015-08-01

    Nickel sulfide (NiS) thin films were deposited on the glass substrates by spray pyrolysis at 250 °C using an aqueous solution which contains nickel chloride hexahydrate and thiourea as precursors. X-ray diffraction analysis confirms that the hexagonal structure is being part of P6{sub 3}/mmc space group of the deposited films with (100) preferred orientation and lattice parameters a = 3.441 Å and c = 5.320 Å. The optical properties, investigated through transmittance and reflectance measurements reveal that the direct band gap energy (Eg) is around 0.55 eV. The electrical study shows a metallic behavior of the current II-VI binary compound. This behavior regarding NiS II-VI binary sulfide was confirmed by numerical studies based on the density functional theory (DFT) were adopted. The ground state quantities, such as lattice parameter, bulk modulus and its pressure derivative as well as the elastic constants were obtained. The values are consistent with the stability of hexagonal structure. The band structure and the states densities of such material were studied. The results show that there is an agreement between experimental and simulation. - Highlights: • NiS thin films are synthesized by Spray pyrolysis. • NiS is a low band gap compound. • These films have interesting electrical properties showing a metallic behavior. • Computational study confirms the electrical measurements.

  13. A Comparative Analysis Among the SRS M&M, NIS, and KID Databases for the Adolescent Idiopathic Scoliosis.

    Science.gov (United States)

    Lee, Nathan J; Guzman, Javier Z; Kim, Jun; Skovrlj, Branko; Martin, Christopher T; Pugely, Andrew J; Gao, Yubo; Caridi, John M; Mendoza-Lattes, Sergio; Cho, Samuel K

    2016-11-01

    Retrospective cohort analysis. A growing number of publications have utilized the Scoliosis Research Society (SRS) Morbidity and Mortality (M&M) database, but none have compared it to other large databases. The objective of this study was to compare SRS complications with those in administrative databases. The Nationwide Inpatient Sample (NIS) and Kid's Inpatient Database (KID) captured a greater number of overall complications while the SRS M&M data provided a greater incidence of spine-related complications following adolescent idiopathic scoliosis (AIS) surgery. Chi-square was used to obtain statistical significance, with p databases were analyzed for AIS patients who underwent fusion. Comparable variables were queried in all three databases, including patient demographics, surgical variables, and complications. Patients undergoing AIS in the SRS database were slightly older (SRS 14.4 years vs. NIS 13.8 years, p database. The SRS database reported fewer overall complications (SRS 3.9% vs. NIS 7.3%, p databases. In contrast, SRS reported higher spine-specific complication rates. Mortality rates were similar between SRS versus NIS (p = .280) and SRS versus KID (p = .08) databases. There are similarities and differences between the three databases. These discrepancies are likely due to the varying data-gathering methods each organization uses to collect their morbidity data. Level IV. Copyright © 2016 Scoliosis Research Society. Published by Elsevier Inc. All rights reserved.

  14. Anomalous Line Shifts From Local Intensity Gradients on the Soho/cds NIS Detector

    Science.gov (United States)

    Haugan, S. V. H.

    1999-04-01

    Line shifts for some emission lines on the SOHO/CDS NIS detector appear to be strongly correlated with local intensity gradients along the slit in a way that seems impossible to explain with a physical solar model. Line widths also show a correlation with local intensity gradients. The most plausible instrumental explanation seems to be an elliptical, tilted point-spread function inducing the line shifts. A toy model demonstrating the essentials of the observed behaviour is presented. The effective point-spread function of the instrument appears to modify the line shape into something other than a Gaussian, leaving highly structured residuals after line fitting, including `ghost' images in some pixel planes. The cause of these effects is yet unknown, but they should warrant experiments on the engineering model to reproduce the observed effects, shedding light on the nature of the aberrations.

  15. A novel hNIS/tdTomato fusion reporter for visualizing the relationship between the cellular localization of sodium iodide symporter and its iodine uptake function under heat shock treatment.

    Science.gov (United States)

    Yeom, Chan Joo; Chung, Taemoon; Youn, Hyewon; Kang, Keon Wook; Lee, Dong Soo; Chung, June-Key

    2015-01-01

    The function of membrane-localized sodium iodide symporter (NIS) determines the efficacy of radioiodine therapy in thyroid cancer. Here, we describe a dual mode reporter fused with human NIS (hNIS) and a red fluorescent protein named tandem dimeric Tomato (tdTomato) for the in vitro and in vivo imaging of hNIS protein expression, localization, and iodide uptake function. Human cervical epithelial adenocarcinoma cell line (HeLa)-hNIS/tdTomato cells were established by transducing a fusion gene expressing hNIS/tdTomato under the control of a cytomegalovirus promoter. Fluorescence imaging, confocal microscopy, and an 125I uptake assay were performed to validate the integrity of the fusion protein. Actinomycin D and cycloheximide were used to block newly synthesized hNIS proteins. In vivo images were acquired using a gamma camera and a Maestro fluorescence imaging device. The fluorescence intensity of membrane-localized hNIS and 125I uptake both were increased after heat shock. Scintigraphy and fluorescence imaging indicated specific accumulation of the hNIS/tdTomato fusion protein in xenografted tumors, supporting the utility of this system for in vivo monitoring of hNIS expression and activity. We developed a novel hNIS/tdTomato dual mode reporter that enables visualization of the expression, localization, and iodine uptake function of hNIS in vitro and in vivo.

  16. Significance of mercury in environmental health - an overview; Bedeutung von Quecksilber in der Umweltmedizin - eine Uebersicht

    Energy Technology Data Exchange (ETDEWEB)

    Schweinsberg, F. [Chemisches Labor, Institut fuer Allgemeine Hygiene und Umwelthygiene, Tuebingen (Germany)

    2002-07-01

    werden tubulaere Nekrosen gesehen. Bei Patienten mit schwerer Nierenfunktionsstoerung sollte auf Amalgamfuellungen verzichtet werden. Durch Amalgamfuellungen koennen in seltenen Faellen allergische Reaktionen (Spaettyp-IV) und intraorale lichenoide Reaktionen (oraler Lichen ruber planus) ausgeloest werden. Der Nachweis subklinischer Effekte durch Amalgamfuellungen und deren gesundheitliche Bedeutung sind noch immer Gegenstand kontroverser Diskussionen. Die Zuordnung unspezifischer Symptome zu einer Quecksilberbelastung aus Amalgamfuellungen ist wissenschaftlich nicht fundiert moeglich. Eine chronische Erkrankung des Nervensystems durch organisches Quecksilber fuehrt zu Paraesthesie, Ataxie, Dysarthrie, Einschraenkung des Sehfeldes und zu Hoerverlusten. Die Belastung mit Quecksilber waehrend der Schwangerschaft, speziell aus Fischkonsum, ist besonders kritisch zu bewerten. Die gesundheitliche Bewertung von Quecksilberbelastungen erfolgt durch Ableitung von Human-Biomonitoring-Werten (HBM): Bei langzeitiger Exposition mit anorganischem Quecksilber ist ab dem HBM-II-Wert fuer Quecksilber im Urin von 25 {mu}g/l eine gesundheitliche Beeintraechtigung moeglich. Der entsprechende HBM-II-Wert fuer organisches Quecksilber im Blut liegt bei 15{mu}g/l, das entspricht einem Quecksilbergehalt in den Haaren von ca. 5 mg/kg. (orig.)

  17. Studierende, Google, die Welt der Bibliotheken und deren kulturelle Bedeutung. Ein Essay zu einem Aufsatz von Amy Bruckman

    Directory of Open Access Journals (Sweden)

    Thomas Hapke

    2006-04-01

    Full Text Available Amy S. Bruckman skizziert in ihrem Artikel „Student research and the internet“ die Welt der Information für Studierende und weist auf die Notwendigkeit einer ernsthaften Reflexion über Information sowie die erkenntnistheoretische Problematik der Bewertung und Gültigkeit von Wissen und damit über die soziale Konstruktion von Wissen und Wissenschaft hin. Informationskompetenz umfasst – mehr als Recherchekompetenz – vor allem Kreativität, den eigenen Informationsprozess bewusst und bedarfsgerecht zu gestalten. In einem Exkurs werden Aktivitäten der Suchmaschine Google hinsichtlich ihrer Bedeutung für den Informationsprozess beleuchtet und der bleibende kulturelle Einfluss von Bibliotheken betont. Über Informationskompetenz hinaus sollten wissenschaftstheoretische und wissenschaftsgeschichtliche Aspekte von Wissenschaft aber auch Methoden und Techniken wissenschaftlichen Arbeitens verpflichtender Teil jedes Studiums sein. Ein Teil, der durchaus auch zur Informationskompetenz-Förderung durch Bibliotheken gehören kann.

  18. Sequence-defined cMET/HGFR-targeted Polymers as Gene Delivery Vehicles for the Theranostic Sodium Iodide Symporter (NIS) Gene.

    Science.gov (United States)

    Urnauer, Sarah; Morys, Stephan; Krhac Levacic, Ana; Müller, Andrea M; Schug, Christina; Schmohl, Kathrin A; Schwenk, Nathalie; Zach, Christian; Carlsen, Janette; Bartenstein, Peter; Wagner, Ernst; Spitzweg, Christine

    2016-08-01

    The sodium iodide symporter (NIS) as well-characterized theranostic gene represents an outstanding tool to target different cancer types allowing noninvasive imaging of functional NIS expression and therapeutic radioiodide application. Based on its overexpression on the surface of most cancer types, the cMET/hepatocyte growth factor receptor serves as ideal target for tumor-selective gene delivery. Sequence-defined polymers as nonviral gene delivery vehicles comprising polyethylene glycol (PEG) and cationic (oligoethanoamino) amide cores coupled with a cMET-binding peptide (cMBP2) were complexed with NIS-DNA and tested for receptor-specificity, transduction efficiency, and therapeutic efficacy in hepatocellular cancer cells HuH7. In vitro iodide uptake studies demonstrated high transduction efficiency and cMET-specificity of NIS-encoding polyplexes (cMBP2-PEG-Stp/NIS) compared to polyplexes without targeting ligand (Ala-PEG-Stp/NIS) and without coding DNA (cMBP2-PEG-Stp/Antisense-NIS). Tumor recruitment and vector biodistribution were investigated in vivo in a subcutaneous xenograft mouse model showing high tumor-selective iodide accumulation in cMBP2-PEG-Stp/NIS-treated mice (6.6 ± 1.6% ID/g (123)I, biological half-life 3 hours) by (123)I-scintigraphy. Therapy studies with three cycles of polyplexes and (131)I application resulted in significant delay in tumor growth and prolonged survival. These data demonstrate the enormous potential of cMET-targeted sequence-defined polymers combined with the unique theranostic function of NIS allowing for optimized transfection efficiency while eliminating toxicity.

  19. What really separates us? Survey of attitudes of young people in the cities of Kikinda (Vojvodina), Nis, Bor (South and East Serbia), and Pristina, Pec, Prizren (Kosovo)

    National Research Council Canada - National Science Library

    Basic, Goran

    2014-01-01

    ... in the cities of Pec, Pristina, Prizren in Kosovo, and Bor, Kikinda, and Nis in Serbia, on whether the question of mutual cooperation is burdened by prejudice and events from the past, and that the...

  20. Protein defence systems against the lantibiotic nisin: Function of the immunity protein NisI and the resistance protein NSR

    Directory of Open Access Journals (Sweden)

    Sakshi eKhosa

    2016-04-01

    Full Text Available Lantibiotics are potential alternatives to antibiotics because of their broad-range killing spectrum. The producer strain is immune against its own synthesized lantibiotic via the expression of two proteins LanI and LanFEG. Recently, gene operons are found in mainly human pathogenic strains, which confer resistance against lantibiotics. Of all the lantibiotics discovered till date, nisin produced by some L. lactis strains is the most prominent member. Nisin has multiple mode of actions of which binding to the cell wall precursor lipid II and subsequent insertion into the bacterial membrane to form pores are the most effective. The nisin producing strains express the lipoprotein NisI to prevent a suicidal effect. NisI binds nisin, inducing a reversible cell clustering to prevent nisin from reaching the membrane. Importantly NisI does not modify nisin and releases it as soon as the concentration in the media drops below a certain level. The human pathogen S. agalactiae is naturally resistant against nisin by expressing a resistance protein called SaNSR, which is a nisin degrading enzyme. By cleaving off the last six amino acids of nisin, its effectiveness is 100-fold reduced. This cleavage reaction appears to be specific for nisin since SaNSR recognizes the C-terminal located lanthionine rings. Recently, the structures of both NisI and SaNSR were determined by NMR and X-ray crystallography, respectively. Furthermore, for both proteins the binding site for nisin was determined. Within this review, the structures of both proteins and their different defence mechanisms are described.

  1. Protein Defense Systems against the Lantibiotic Nisin: Function of the Immunity Protein NisI and the Resistance Protein NSR

    Science.gov (United States)

    Khosa, Sakshi; Lagedroste, Marcel; Smits, Sander H. J.

    2016-01-01

    Lantibiotics are potential alternatives to antibiotics because of their broad-range killing spectrum. The producer strain is immune against its own synthesized lantibiotic via the expression of two proteins LanI and LanFEG. Recently, gene operons are found in mainly human pathogenic strains, which confer resistance against lantibiotics. Of all the lantibiotics discovered till date, nisin produced by some Lactococcus lactis strains is the most prominent member. Nisin has multiple mode of actions of which binding to the cell wall precursor lipid II and subsequent insertion into the bacterial membrane to form pores are the most effective. The nisin producing strains express the lipoprotein NisI to prevent a suicidal effect. NisI binds nisin, inducing a reversible cell clustering to prevent nisin from reaching the membrane. Importantly NisI does not modify nisin and releases it as soon as the concentration in the media drops below a certain level. The human pathogen Streptococcus agalactiae is naturally resistant against nisin by expressing a resistance protein called SaNSR, which is a nisin degrading enzyme. By cleaving off the last six amino acids of nisin, its effectiveness is 100-fold reduced. This cleavage reaction appears to be specific for nisin since SaNSR recognizes the C-terminal located lanthionine rings. Recently, the structures of both NisI and SaNSR were determined by NMR and X-ray crystallography, respectively. Furthermore, for both proteins the binding site for nisin was determined. Within this review, the structures of both proteins and their different defense mechanisms are described. PMID:27148193

  2. Formation of Multiple-Phase Catalysts for the Hydrogen Storage of Mg Nanoparticles by Adding Flowerlike NiS.

    Science.gov (United States)

    Xie, Xiubo; Ma, Xiujuan; Liu, Peng; Shang, Jiaxiang; Li, Xingguo; Liu, Tong

    2017-02-22

    In order to enhance the hydrogen storage properties of Mg, flowerlike NiS particles have been successfully prepared by solvothermal reaction method, and are subsequently ball milled with Mg nanoparticles (NPs) to fabricate Mg-5 wt % NiS nanocomposite. The nanocomposite displays Mg/NiS core/shell structure. The NiS shell decomposes into Ni, MgS and Mg2Ni multiple-phases, decorating on the surface of the Mg NPs after the first hydrogen absorption and desorption cycle at 673 K. The Mg-MgS-Mg2Ni-Ni nanocomposite shows enhanced hydrogenation and dehydrogenation rates: it can quickly uptake 3.5 wt % H2 within 10 min at 423 K and release 3.1 wt % H2 within 10 min at 573 K. The apparent hydrogen absorption and desorption activation energies are decreased to 45.45 and 64.71 kJ mol(-1). The enhanced sorption kinetics of the nanocomposite is attributed to the synergistic catalytic effects of the in situ formed MgS, Ni and Mg2Ni multiple-phase catalysts during the hydrogenation/dehydrogenation process, the porthole effects for the volume expansion and microstrain of the phase transformation of Mg2Ni and Mg2NiH4 and the reduced hydrogen diffusion distance caused by nanosized Mg. This novel method of in situ producing multiple-phase catalysts gives a new horizon for designing high performance hydrogen storage material.

  3. A food-grade cloning vector for lactic acid bacteria based on the nisin immunity gene nisI.

    Science.gov (United States)

    Takala, T M; Saris, P E J

    2002-08-01

    A new food-grade cloning vector for lactic acid bacteria was constructed using the nisin immunity gene nisI as a selection marker. The food-grade plasmid, pLEB 590, was constructed entirely of lactococcal DNA: the pSH 71 replicon, the nisI gene, and the constitutive promoter P45 for nisI expression. Electroporation into Lactococcus lactis MG 1614 with 60 international units (IU) nisin/ml selection yielded approximately 10(5) transformants/ micro g DNA. MG 1614 carrying pLEB 590 was shown to be able to grow in medium containing a maximum of 250 IU nisin/ml. Plasmid pLEB 590 was successfully transformed into an industrial L. lactis cheese starter carrying multiple cryptic plasmids. Suitability for molecular cloning was confirmed by cloning and expressing the proline iminopeptidase gene pepI from Lactobacillus helveticus in L. lactis and Lb. plantarum. These results show that the food-grade expression system reported in this paper has potential for expression of foreign genes in lactic acid bacteria in order to construct improved starter bacteria for food applications.

  4. Mammals of the World: MaNIS as an example of data integration in a distributed network environment

    Directory of Open Access Journals (Sweden)

    Barbara R Stein

    2004-01-01

    Full Text Available Natural history collections are the authoritative source of knowledge about the identity, evolutionary relationships, and attributes of species with which we share this planet. As such, collections of research specimens play a central and critical role in the conservation and sustainable use of biodiversity. The potential contribution of specimen data to systematic, genomic, and ecological analyses is enormous, and will be orders of magnitude greater when information is made easily accessible via distributed networks compared with stand-alone database systems in use up to the present. The Mammal Networked Information System (MaNIS is a distributed database network that permits participating institutions to provide web-based global access to their collections data for research, education and informed decision-making. The simplicity of the network’s design ensures that any institution wishing to join MaNIS may do so at relatively little cost and with relatively little technical expertise. Although development of MaNIS and its underlying architecture relied on a number of key programming tasks and innovations, much of what the project can offer at this pivotal juncture is insight into its approach and a template by which other disciplines can engage in a similar process with equal success.

  5. Constructing Multifunctional Metallic Ni Interface Layers in the g-C3N4 Nanosheets/Amorphous NiS Heterojunctions for Efficient Photocatalytic H2 Generation.

    Science.gov (United States)

    Wen, Jiuqing; Xie, Jun; Zhang, Hongdan; Zhang, Aiping; Liu, Yingju; Chen, Xiaobo; Li, Xin

    2017-04-26

    The construction of exceptionally robust and high-quality semiconductor-cocatalyst heterojunctions remains a grand challenge toward highly efficient and durable solar-to-fuel conversion. Herein, novel graphitic carbon nitride (g-C3N4) nanosheets decorated with multifunctional metallic Ni interface layers and amorphous NiS cocatalysts were fabricated via a facile three-step process: the loading of Ni(OH)2 nanosheets, high-temperature H2 reduction, and further deposition of amorphous NiS nanosheets. The results demonstrated that both robust metallic Ni interface layers and amorphous NiS can be utilized as electron cocatalysts to markedly boost the visible-light H2 evolution over g-C3N4 semiconductor. The optimized g-C3N4-based photocatalyst containing 0.5 wt % Ni and 1.0 wt % NiS presented the highest hydrogen evolution of 515 μmol g(-1) h(-1), which was about 2.8 and 4.6 times as much as those obtained on binary g-C3N4-1.0%NiS and g-C3N4-0.5%Ni, respectively. Apparently, the metallic Ni interface layers play multifunctional roles in enhancing the visible-light H2 evolution, which could first collect the photogenerated electrons from g-C3N4, and then accelerate the surface H2-evolution reaction kinetics over amorphous NiS cocatalysts. More interestingly, the synergetic effects of metallic Ni and amorphous NiS dual-layer electron cocatalysts could also improve the TEOA-oxidation capacity through upshifting the VB levels of g-C3N4. Comparatively speaking, the multifunctional metallic Ni layers are dominantly favorable for separating and transferring photoexcited charge carriers from g-C3N4 to amorphous NiS cocatalysts owing to the formation of Schottky junctions, whereas the amorphous NiS nanosheets are mainly advantageous for decreasing the thermodynamic overpotentials for surface H2-evolution reactions. It is hoped that the implantation of multifunctional metallic interface layers can provide a versatile approach to enhance the photocatalytic H2 generation over

  6. Controllable Preparation of Square Nickel Chalcogenide (NiS and NiSe2) Nanoplates for Superior Li/Na Ion Storage Properties.

    Science.gov (United States)

    Fan, Haosen; Yu, Hong; Wu, Xinglong; Zhang, Yu; Luo, Zhongzhen; Wang, Huanwen; Guo, Yuanyuan; Madhavi, Srinivasan; Yan, Qingyu

    2016-09-28

    A facile and bottom-up approach has been presented to prepare 2D Ni-MOFs based on cyanide-bridged hybrid coordination polymers. After thermally induced sulfurization and selenization processes, Ni-MOFs were successfully converted into NiS and NiSe2 nanoplates with carbon coating due to the decomposition of its organic parts. When evaluated as anodes of Li-ion batteries (LIBs) and Na-ion batteries (NIBs), NiS and NiSe2 nanoplates show high specific capacities, excellent rate capabilities, and stable cycling stability. The NiS plates show good Li storage properties, while NiSe2 plates show good Na storage properties as anode materials. The study of the diffusivity of Li(+) in NiS and Na(+) in NiSe2 shows consistent results with their Li/Na storage properties. The 2D MOFs-derived NiS and NiSe2 nanoplates reported in this work explore a new approach for the large-scale synthesis of 2D metal sulfides or selenides with potential applications for advanced energy storage.

  7. Enhanced iodide sequestration by 3-biphenyl-5,6-dihydroimidazo 2,1-b thiazole in sodium/iodide sym-porter (NIS)-expressing cells

    Energy Technology Data Exchange (ETDEWEB)

    Lecat-Guillet, N.; Ambroise, Y. [CEA, DSV, Dept Bioorgan Chem andt IsotopLabelling, Inst Biol and Technol, iBiTecS, F-91191 Gif Sur Yvette (France)

    2008-07-01

    The ability of the sodium/iodide sym-porter (NIS) to take up iodide has long provided the basis for cyto-reductive gene therapy and cancer treatment with radio-iodide. One of the major limitations of this approach is that radio-iodide retention in NIS-expressing cells is not sufficient for their destruction. We identified and characterized a small organic molecule capable of increasing iodide retention in HEK293 cells permanently transfected with human NIS cDNA (hNIS-HEK293) and in the rat thyroid-derived cell line FRTL-5. In the presence of 3-biphenyl-4'-yl-5,6-dihydroimidazo[2,1-b)thiazole (ISA1), the transmembrane iodide concentration gradient was increased up to 4.5-fold. Our experiments indicate that the imidazo-thiazole derivative acts either by inhibiting anion efflux mechanisms, or by promoting the relocation of iodide into subcellular compartments. This new compound is not only an attractive chemical tool to investigate the mechanisms of iodide flux at the cellular level, but also opens promising perspectives in the treatment of cancer after NIS gene transfer. (authors)

  8. The C-terminus of nisin is important for the ABC transporter NisFEG to confer immunity in Lactococcus lactis.

    Science.gov (United States)

    AlKhatib, Zainab; Lagedroste, Marcel; Zaschke, Julia; Wagner, Manuel; Abts, André; Fey, Iris; Kleinschrodt, Diana; Smits, Sander H J

    2014-10-01

    The lantibiotic nisin is a small 3.4 kDa antimicrobial peptide, which acts against Gram-positive bacteria in the nmol/L range. Nisin is produced and secreted by several Lactococcus lactis strains to ensure advantages against other bacteria in their habitat. Nisin contains five specific lanthionine rings of which the first two are important for Lipid II binding and the last two are crucial for the pore formation in the membrane. To gain immunity against nisin, the producing strain is expressing an ABC transporter called NisFEG, which expels nisin from the membrane. As a result six to eightfold more nisin is needed to affect the cells. The hydrolysis of ATP by NisFEG is required for this immunity as shown by a mutant, where the ATP hydrolysis is disrupted (NisFH181A EG). Furthermore, NisFEG recognizes the C-terminus of nisin, since deletion of the last six amino acids as well as of the last ring lowered the fold of immunity displayed by NisFEG.

  9. L-cysteine-assisted synthesis of hierarchical NiS2 hollow spheres supported carbon nitride as photocatalysts with enhanced lifetime

    Science.gov (United States)

    Zhu, Chengzhang; Jiang, Zhifeng; Chen, Linlin; Qian, Kun; Xie, Jimin

    2017-03-01

    Novel hierarchical NiS2 hollow spheres modified by graphite-like carbon nitride were prepared using a facile L-cysteine-assisted solvothermal route. The NiS2/g-C3N4 composites exhibited excellent photocatalytic efficiency in rhodamine B, methyl orange and ciprofloxacin degradation as compared to single g-C3N4 and NiS2, which could be due to the synergistic effects of the unique hollow sphere-like structure, strong visible-light absorption and increased separation rate of the photoinduced electron–hole pairs at the intimate interface of heterojunctions. A suitable combination of g-C3N4 with NiS2 showed the best photocatalytic performance. In addition, an electron spin resonance and trapping experiment demonstrated that the photogenerated hydroxyl radicals and superoxide radicals were the two main photoactive species in photocatalysis. A possible photocatalytic mechanism of NiS2/g-C3N4 composites under visible light irradiation is also proposed. The strategy presented here can be extended to a general strategy for constructing 3D/2D heterostructured photocatalysts for broad applications in photocatalysis.

  10. Two-phase synthesis of olive-like NiS particles and chain-like Bi2S3 nanowires

    Directory of Open Access Journals (Sweden)

    Yuan Yawen

    2015-03-01

    Full Text Available Highly dispersed olive-like NiS particles were synthesized in a liquid-liquid biphasic system at room temperature, where nickel xanthate in organic solvents (toluene and benzene and sodium sulfide in water solution were used as nickel and sulfide sources, respectively. NiS particles were formed at the stabilized phase interface. The structures, chemical composition and optical characteristics of the products were investigated by transmission electron microscopy, scanning electron microscopy, X-ray photoelectron spectroscopy and ultraviolet-visible spectroscopy. The organic solvents obviously influenced the morphology of the NiS particles. The olive-like NiS with smooth surface and sharp ends was obtained at benzene/water interface, while spindle-like NiS particles with rough surface and circle ends were formed when using toluene as a solvent. Analogously, chainlike Bi2S3 nanowires were produced at chloroform/water interface. The effect of the experiment parameters including reaction time, solvent and concentration of reactants on the size and morphology of the products was discussed in detail and a possible formation mechanism was suggested.

  11. Synthesis of cellulose triacetate from cotton cellulose by using NIS as a catalyst under mild reaction conditions.

    Science.gov (United States)

    El Nemr, Ahmed; Ragab, Safaa; El Sikaily, Amany; Khaled, Azza

    2015-10-05

    This research discusses the acetylation of cotton cellulose with acetic anhydride without solvents. The acetylation was done in the presence of different amounts of N-Iodosuccinimide (NIS) as a catalyst; this took place under mild reaction conditions. The extent of acetylation was measured by the weight percent gain (WPG) that varied from 24.71 to 71.83%. Cotton cellulose acetates, with the degree of substitution (DS) that ranged from 0.89 to 2.84, were prepared in one step. The cellulose triacetate, with a degree of substitution (DS) 2.84, was obtained. The WPG and DS were easily controlled by changing the reaction duration (1-5h), and the concentration of the catalyst (0.05 g, 0.075 g and 0.10 g for 1g of cellulose) in 25 ml of acetic anhydride. NIS was recognized as a novel and more successful catalyst for the acetylation of hydroxyl groups in cotton cellulose. Formation of the acetates and the calculation of the degree of substitution were performed by FT-IR, Raman, and (1)H NMR.

  12. Atomic layer deposition of NiS and its application as cathode material in dye sensitized solar cell

    Energy Technology Data Exchange (ETDEWEB)

    Mahuli, Neha [Center for Research in Nanotechnology and Sciences, Indian Institute of Technology Bombay, Powai, Mumbai 400076 (India); Sarkar, Shaibal K., E-mail: shaibal.sarkar@iitb.ac.in [Department of Energy Science and Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076 (India)

    2016-01-15

    Nickel sulfide (NiS) is grown by atomic layer deposition (ALD) using sequential exposures of bis(2,2,6,6-tetramethylheptane-3,5-dionate)nickel(II) [Ni(thd){sub 2}] and hydrogen sulfide (H{sub 2}S) at 175 °C. Complementary combinations of in situ and ex situ characterization techniques are used to understand the deposition chemistry and the nature of film growth. The saturated growth rate of ca. 0.21 Å per ALD cycle is obtained, which is constant within the ALD temperature window (175–250 °C). As deposited films on glass substrates are found polycrystalline without any preferred orientation. Electrical transport measurement reveals degenerative/semimetallic characteristics with a carrier concentration of ca. 9 × 10{sup 22} cm{sup −3} at room temperature. The ALD grown NiS thin film demonstrates high catalytic activity for the reduction of I{sup −}/I{sub 3}{sup −} electrolyte that opens its usage as cost-effective counter electrode in dye sensitized solar cells, replacing Pt.

  13. Changes in gastric sodium-iodide symporter (NIS) activity are associated with differences in thyroid gland sensitivity to perchlorate during metamorphosis.

    Science.gov (United States)

    Carr, James A; Murali, Sharanya; Hu, Fang; Goleman, Wanda L; Carr, Deborah L; Smith, Ernest E; Wages, Mike

    2015-08-01

    We investigated stage-dependent changes in sensitivity of the thyroid gland to perchlorate during development of African clawed frog tadpoles (Xenopus laevis) in relation to non-thyroidal iodide transporting tissues. Perchlorate-induced increases in thyroid follicle cell size and colloid depletion were blunted when exposures began at Nieuwkoop-Faber (NF) stage 55 compared to when exposures began at NF stages 49 or 1-10. To determine if the development of other iodide transporting tissues may contribute to this difference we first examined which tissues expressed transcripts for the sodium dependent iodide symporter (NIS). RT-PCR analysis revealed that NIS was expressed in stomach and small intestine in addition to the thyroid gland of X. laevis tadpoles. NIS mRNA was not detected in lung, kidney, skin, gill, muscle, heart or liver. Perchlorate sensitive (125)I uptake was found in stomach, lung, kidney, gill, and small intestine but not muscle, liver, or heart. Perchlorate-sensitive (125)I uptake by stomach was 6-10 times greater than in any other non-thyroidal tissue in tadpoles. While NF stage 49 tadpoles exhibited perchlorate-sensitive uptake in stomach it was roughly 4-fold less than that observed in NF stage 55 tadpoles. Although abundance of NIS gene transcripts was greater in stomachs from NF stage 55 compared to NF stage 49 tadpoles this difference was not statistically significant. We conclude that gastric iodide uptake increases between NF stages 49 and 55, possibly due to post-translational changes in NIS glycosylation or trafficking within gastric mucosal cells. These developmental changes in gastric NIS gene expression may affect iodide availability to the thyroid gland.

  14. Size-dependent and intra-band photoluminescence of NiS2 nano-alloys synthesized by microwave assisted hydrothermal technique

    CSIR Research Space (South Africa)

    Linganiso, C

    2013-03-01

    Full Text Available Journal of Alloys and Compounds March 2013/ Vol 552, pp 345-350 Size-dependent and intra-band photoluminescence of NiS2 nano- alloys synthesized by microwave assisted hydrothermal technique Ella Cebisa Linganiso a,b, Sabelo Dalton Mhlanga b...

  15. The pan-DAC inhibitor LBH589 is a multi-functional agent in breast cancer cells: cytotoxic drug and inducer of sodium-iodide symporter (NIS).

    Science.gov (United States)

    Fortunati, N; Catalano, M G; Marano, F; Mugoni, V; Pugliese, M; Bosco, O; Mainini, F; Boccuzzi, G

    2010-12-01

    New drugs with anti-tumor activity, also able to modify the expression of selected molecules, are under evaluation in breast cancer which is becoming resistant to conventional treatment, or in metastatic disease. The sodium-iodide symporter (NIS), which mediates iodide uptake into thyroid cells, and is the molecular basis of radioiodine imaging and therapy in thyroid cancer, is also expressed in a large portion of breast tumors. Since NIS expression in breast cancer is not sufficient for a significant iodide uptake, drugs able to induce its expression and correct function are under evaluation. In the present study, we report for the first time that the pan-deacetylase (DAC) inhibitor LBH589 (panobinostat) significantly induced NIS, both as mRNA and as protein, through the increase of NIS promoter activity, with the final consequence of obtaining a significant up-take of iodide in MCF7, T47D, and MDA-MB231 breast cancer cells. Moreover, we observed that LBH589 causes a significant reduction in cell viability of estrogen-sensitive and -insensitive breast cancer cells within nanomolar range. The anti-tumor effect of LBH589 is sustained by apoptosis induction and cell cycle arrest in G(2)/M. In conclusion, our data suggest that LBH589 might be a powerful tool in the management of breast cancer due to its multiple effects and support a potential application of LBH589 in the diagnosis and treatment of this disease.

  16. Inhibition of miR-146b expression increases radioiodine-sensitivity in poorly differential thyroid carcinoma via positively regulating NIS expression

    Energy Technology Data Exchange (ETDEWEB)

    Li, Luchuan; Lv, Bin; Chen, Bo [Department of General Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012 (China); Guan, Ming [Department of General Surgery, Qihe People' s Hospital, Qihe, Shandong 251100 (China); Sun, Yongfeng [Department of General Surgery, Licheng District People' s Hospital, Jinan, Shandong 250115 (China); Li, Haipeng [Department of General Surgery, Caoxian People' s Hospital, Caoxian, Shandong 274400 (China); Zhang, Binbin; Ding, Changyuan; He, Shan [Department of General Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012 (China); Zeng, Qingdong, E-mail: qingdz0201@163.com [Department of General Surgery, Shandong University Qilu Hospital, Jinan, Shandong 250012 (China)

    2015-07-10

    Dedifferentiated thyroid carcinoma (DTC) with the loss of radioiodine uptake (RAIU) is often observed in clinical practice under radioiodine therapy, indicating the challenge for poor prognosis. MicroRNA (miRNA) has emerged as a promising therapeutic target in many diseases; yet, the role of miRNAs in RAIU has not been generally investigated. Based on recent studies about miRNA expression in papillary or follicular thyroid carcinomas, the expression profiles of several thyroid relative miRNAs were investigated in one DTC cell line, derived from normal DTC cells by radioiodine treatment. The top candidate miR-146b, with the most significant overexpression profiles in dedifferentiated cells, was picked up. Further research found that miR-146b could be negatively regulated by histone deacetylase 3 (HDAC3) in normal cells, indicating the correlation between miR-146b and Na{sup +}/I{sup −} symporter (NIS)-mediated RAIU. Fortunately, it was confirmed that miR-146b could regulate NIS expression/activity; what is more important, miR-146b interference would contribute to the recovery of radioiodine-sensitivity in dedifferentiated cells via positively regulating NIS. In the present study, it was concluded that NIS-mediated RAIU could be modulated by miR-146b; accordingly, miR-146b might serve as one of targets to enhance efficacy of radioactive therapy against poorly differential thyroid carcinoma (PDTC). - Highlights: • Significant upregulated miR-146b was picked up from thyroid relative miRNAs in DTC. • MiR-146b was negatively regulated by HDAC3 in normal thyroid carcinoma cells. • NIS activity and expression could be regulated by miR-146b in thyroid carcinoma. • MiR-146b inhibition could recover the decreased radioiodine-sensitivity of DTC cells.

  17. 重组质粒pMG36e-nisI-gfp在乳酸菌中的应用%Application of Recombined Plasmid pMG36e-nisI-gfp in Lactic Acid Bacteria

    Institute of Scientific and Technical Information of China (English)

    代伟丽; 王艳萍; 王菁蕊; 白小佳

    2012-01-01

    本研究将带有nisI和gfp(绿色荧光蛋白)基因的乳酸菌表达栽体pMG36e-nisI-gfp转化至乳酸菌中,观察其在宿主内的稳定性.对重组菌进行了菌体形态、传代培养、质粒验证等研究,考察了该质粒的稳定性.结果显示:重组菌在不含抗生素的培养基中连续传代20代后,质粒丢失率低;菌体大小和形态基本不变;质粒经HindⅢ酶切后大小不变;GFP在第0、5、10、15和20代宿主菌中都可以表达,表达量没有明显差别,在SDS-PAGE中的带型一致;初步的动物实验验证了该质粒作为遗传标记的应用效果.说明该质粒在宿主菌中具有良好的稳定性.%A constitutive expression vector for lactic acid bacteria,named pMG36e-rnisl-gfp,was constructed first,using nisl as the selection marker and GFP as the reporter protein. In this work, the expression vector was electroporated into some LABs and its plasmid stability was evaluated. The results showed that the loss rate of the plasmid strains harboring pMG36e-nisl-gfp was still low even after 20 generations during the subculture in a liquid culture medium without antibiotics. The size and shape of the recombined strain did not change before and after subculture. The expression of GFP in the 0th, 5th, 10th, 15th and 20th generations showed no significant difference. The effect of pMG36e-isl-gfp as a reporter protein was proved in animal experiments. It was concluded that the plasmid pMG36e-nisl-gfp had good stability.

  18. [Tooth macromorphological and ultrastructural analysis of osteological material from the medieval locality of St. Panteleimon Church in Nis].

    Science.gov (United States)

    Mitić, Nadica; Mitić, Aleksandar; Mitić, Vladimir; Savić, Vojin; Nikolić, Marija

    2010-01-01

    Analysis of macromorphological and ultrastructural tooth characteristics of osteological material from the medieval site of St. Pantaleimon Church in Nis provides us with insight on the life, nutrition and habits of medieval population, as well as the structure and composition of their teeth. The aim of this research, based on the tooth inspection of skeletal remains from the medieval site of St. Pantaleimon Church in Nis, was to analyze macromorphological characteristics, ultrastructure of the dental tissue of maxillary and mandibular molars, canines and incisors, as well as their chemical composition. Macromorphological and ultrastructural analysis of the dental tissue of osteological material dating from the 12th century included 1312 teeth with advanced abrasion. Macromorphological changes were detected by using a dental mirror, probe and radiography. After irrigation, the teeth were prepared using the standard procedure and analyzed by scanning electronic microscopy (JEOL-JSM-5300). Chemical analysis was done by expanded downscaling (EDS) method for Mg, P, Ca. The analysis detected second degree abrasions of all teeth in individuals aged 20-25 years. Third and fourth degree abrasions of teeth were detected in individuals aged over 40 years. Ultrastructural analysis showed a complete obliteration of dentin tubules and pulp of the lower incisors, the apposition of intratubular dentin inside the tubules, as well as extensive deformity and loss of dentin structure on molars with preserved pulp volume and nerve fiber calcification. The calcification of nerve fibers showed that the formation of intratubular dentin was proportional with the biological potential of pulp and the degree of abrasion, and inversely proportional with the size of dentin surface. Chemical analysis showed that in the analyzed teeth Ca composition was slightly lower than that in the control group, P composition was almost identical, while Mg composition was multiply increased in comparison to

  19. Phase I Trial of Intratumoral Administration of NIS Expressing Strain of Measles Virus in Unresectable or Recurrent Malignant Peripheral Nerve Sheath Tumor

    Science.gov (United States)

    2016-10-01

    or Recurrent Malignant Peripheral Nerve Sheath Tumor PRINCIPAL INVESTIGATOR: Dusica Babovic-Vuksanovic, MD CONTRACTING ORGANIZATION: Mayo Clinic...20164. TITLE AND SUBTITLE Recurrent Malignant Peripheral Nerve Sheath Tumor 5a. CONTRACT NUMBER Phase I Trial of Intratumoral Administration of NIS...Expressing Strain of Measles Virus in Unresectable or Recurrent Malignant Peripheral Nerve Sheath Tumor 5b. GRANT NUMBER W81XWH-15-1-0115 5c. PROGRAM

  20. Large Fermi Surface of Heavy Electrons at the Border of Mott Insulating State in NiS2

    Science.gov (United States)

    Friedemann, S.; Chang, H.; Gamża, M. B.; Reiss, P.; Chen, X.; Alireza, P.; Coniglio, W. A.; Graf, D.; Tozer, S.; Grosche, F. M.

    2016-01-01

    One early triumph of quantum physics is the explanation why some materials are metallic whereas others are insulating. While a treatment based on single electron states is correct for most materials this approach can fail spectacularly, when the electrostatic repulsion between electrons causes strong correlations. Not only can these favor new and subtle forms of matter, such as magnetism or superconductivity, they can even cause the electrons in a half-filled energy band to lock into position, producing a correlated, or Mott insulator. The transition into the Mott insulating state raises important fundamental questions. Foremost among these is the fate of the electronic Fermi surface and the associated charge carrier mass, as the Mott transition is approached. We report the first direct observation of the Fermi surface on the metallic side of a Mott insulating transition by high pressure quantum oscillatory measurements in NiS2. Our results point at a large Fermi surface consistent with Luttinger’s theorem and a strongly enhanced quasiparticle effective mass. These two findings are in line with central tenets of the Brinkman-Rice picture of the correlated metal near the Mott insulating state and rule out alternative scenarios in which the carrier concentration vanishes continuously at the metal-insulator transition. PMID:27174799

  1. Large Fermi Surface of Heavy Electrons at the Border of Mott Insulating State in NiS2.

    Science.gov (United States)

    Friedemann, S; Chang, H; Gamża, M B; Reiss, P; Chen, X; Alireza, P; Coniglio, W A; Graf, D; Tozer, S; Grosche, F M

    2016-05-12

    One early triumph of quantum physics is the explanation why some materials are metallic whereas others are insulating. While a treatment based on single electron states is correct for most materials this approach can fail spectacularly, when the electrostatic repulsion between electrons causes strong correlations. Not only can these favor new and subtle forms of matter, such as magnetism or superconductivity, they can even cause the electrons in a half-filled energy band to lock into position, producing a correlated, or Mott insulator. The transition into the Mott insulating state raises important fundamental questions. Foremost among these is the fate of the electronic Fermi surface and the associated charge carrier mass, as the Mott transition is approached. We report the first direct observation of the Fermi surface on the metallic side of a Mott insulating transition by high pressure quantum oscillatory measurements in NiS2. Our results point at a large Fermi surface consistent with Luttinger's theorem and a strongly enhanced quasiparticle effective mass. These two findings are in line with central tenets of the Brinkman-Rice picture of the correlated metal near the Mott insulating state and rule out alternative scenarios in which the carrier concentration vanishes continuously at the metal-insulator transition.

  2. Enhancement of photocatalytic H2 evolution over TiO2 nano-sheet films by surface loading NiS nanoparticles

    Science.gov (United States)

    Liu, Yaopeng; Tang, Chunni

    2016-05-01

    NiS/TiO2 nano-sheet films (NiS/TiO2 NSFs) photocatalysts were prepared by loading NiS nanoparticles as noble metal-free cocatalysts on the surface of TiO2 films through a solvothermal method. The prepared samples were characterized by XRD, SEM, EDS, UV-Vis absorption spectra and XPS analysis. The photocatalytic H2 evolution and photoluminescence spectroscopy (PL) experiments indicated that the NiS cocatalysts could efficiently promote the separation of photogenerated charge carriers in TiO2 and consequently enhance the H2 evolution activity. The hydrogen yield obtained from the optimal sample reached 4.31 μmol cm-2 at 3.0 h and the corresponding energy efficiency was about 0.26%, which was 21 times higher than that of pure TiO2 NSF. A possible photocatalytic mechanism of NiS cocatalyst on the improvement of the photocatalytic performance of TiO2 NSF was also proposed.

  3. In Situ Fabrication of CoS and NiS Nanomaterials Anchored on Reduced Graphene Oxide for Reversible Lithium Storage.

    Science.gov (United States)

    Tan, Yingbin; Liang, Ming; Lou, Peili; Cui, Zhonghui; Guo, Xiangxin; Sun, Weiwei; Yu, Xuebin

    2016-06-15

    CoS and NiS nanomaterials anchored on reduced graphene oxide (rGO) sheets, synthesized via combination of hydrothermal with sulfidation process, are studied as high-capacity anode materials for the reversible lithium storage. The obtained CoS nanofibers and NiS nanoparticles are uniformly dispersed on rGO sheets without aggregation, forming the sheet-on-sheet composite structure. Such nanoarchitecture can not only facilitate ion/electron transport along the interfaces, but also effectively prevent metal-sulfide nanomaterials aggregation during the lithium reactions. Both the rGO-supported CoS nanofibers (NFs) and NiS nanoparticles (NPs) show superior lithium storage performance. In particular, the CoS NFs-rGO electrodes deliver the discharge capacity as high as 939 mA h g(-1) after the 100th cycle at 100 mA g(-1) with Coulombic efficiency above 98%. This strategy for construction of such composite structure can also synthesize other metal-sulfide-rGO nanomaterials for high-capacity lithium-ion batteries.

  4. 乳链菌肽自身免疫基因nisI的表达对乳链菌肽产量的影响%Enhanced nisin production by overexpression of nisin immunity gene nisI in the nisin-producing strain

    Institute of Scientific and Technical Information of China (English)

    胡红梅; 蒋立科; 林宇恒; 还连栋; 钟瑾

    2010-01-01

    [目的]通过基因工程手段增加乳链菌肽(nisin)自身免疫基因nisI在nisin产生菌Lactococcus lactis NZ9800/pHJ201中的表达水平,增强该菌对nisin的抗性,从而达到提高nisin产量的目的.[方法]将带有强组成型启动子P59的免疫基因nisI克隆到nisin表达质粒pHJ201上,将重组质粒引入L.lactus NZ9800中,使nisI基因过量表达,得到重组菌株L.lactis NZ9800/pHMI,并比较该重组菌株与对照菌株L.lactis NZ9800/pHJ201的生长曲线、对nisin的抗性水平、抑菌活性及nisin产量的差异.[结果]nisI的表达对重组菌的生长速度没有明显的影响,却能促使重组菌株对nisin的抗性水平提高25%、在发酵6h和8h时,nisin的产量分别提高32%和25%.[结论]增加乳链菌肽自身免疫基因nisI的表达可以提高产生菌对nisin的抗性,从而提高乳链菌肽产量.

  5. Observation of the structural, optical and magnetic properties during the transformation from hexagonal NiS nano-compounds to cubic NiO nanostructures due to thermal oxidation

    Energy Technology Data Exchange (ETDEWEB)

    Linganiso, E.C., E-mail: elinganiso@csir.co.za [National Centre for Nano-Structured Materials, Council for Scientific and Industrial Research, P.O. Box 395, Pretoria 0001 (South Africa); DST/NRF Centre of Excellence in Strong Materials, Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, Johannesburg, Wits 2050 (South Africa); Mwakikunga, B.W., E-mail: bmwakikunga@csir.co.za [National Centre for Nano-Structured Materials, Council for Scientific and Industrial Research, P.O. Box 395, Pretoria 0001 (South Africa); Coville, N.J. [DST/NRF Centre of Excellence in Strong Materials, Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, Johannesburg, Wits 2050 (South Africa); Mhlanga, S.D. [Department of Applied Chemistry, University of Johannesburg, PO Box 17011, Doornfontein, 2028 Johannesburg (South Africa)

    2015-04-25

    Graphical abstract: The transition temperature of 350 °C for the formation of c-NiO from h-NiS oxidation was obtained from structural and optical property studies and by calculating the number of spins obtained from the EPR data. Vibrating sample magnetometry (VSM) shows that this pure NiS has both ferromagnetic ordering and paramagnetic domains. Further, the transition temperature of −9 °C of the pure α-NiS nano-alloys was confirmed by performing electrical measurements on the as-synthesized material. - Highlights: • Single hexagonal phase NiS obtained by microwave assisted hydrothermal synthesis. • NiS nanoalloys show both ferromagnetic and paramagnetic domains by VSM. • Structural evolution of annealed NiS and temperature dependent NiS oxidation presented. • Phase transition from NiS to NiO studied and correlated to the EPR spin population data and crystallite size. • Ferromagnetic and paramagnetic ordering observed for the raw NiS nanostructures. - Abstract: Single phase α-NiS nano-compounds with uniformly distributed hierarchical networks were synthesized by a microwave-assisted hydrothermal technique. The materials were evaluated for thermal stability under an oxidative environment and at temperatures between 150 °C and 600 °C. NiS materials showed stability at 300 °C and NiO formation was observed from 350 °C to 600 °C. The annealing effect on the crystalline size and IR absorption of the annealed samples is reported by XRD and FTIR studied. The EPR properties of the annealed materials were studied and compared to the oxidized materials. The transition temperature of 350 °C for the formation of NiO from NiS oxidation was confirmed by calculating the number of spins obtained from the EPR data. Vibrating sample magnetometry (VSM) shows that this pure NiS has both ferromagnetic ordering and paramagnetic domains. Further, the transition temperature of −9 °C of the pure α-NiS nano-compounds was confirmed by performing electrical

  6. New adiabatic calorimeter for realization the triple point of water in metallic-sealed cell at NIS-Egypt

    Directory of Open Access Journals (Sweden)

    El Matarawy Ahmed Ali

    2016-01-01

    Full Text Available The thermal metrology laboratory, at the National Institute for Standards (NIS-Egypt, has been working during the last three years on the development of metallic-sealed cells for the realization of the triple point of water (TPW, 273.16 K [H. Preston-Thomas, Metrologia 27, 3 (1990]. A metallic-sealed cell has been already developed and characterized in the past [A. El Matarawy, M.G. Ahmed, Int. J. Metrol. Qual. Eng. 5, 401 (2014, M.G. Ahmed, A. El Matarawy, H.M. Abo Dorra, J. Phys. Sci. Appl. 1 (2015]. The classical large triple point of water cell and metallic-sealed cell showed a discrepancy of 0.7 mK [A. El Matarawy, M.G. Ahmed, Int. J. Metrol. Qual. Eng. 5, 401 (2014]. The main target of this work is to get the lowest possible uncertainty in calibrating Capsule Standard Platinum Resistance Thermometers (CSPRTs under adiabatic conditions. The full system is composed of a metallic-sealed cell and an improved adiabatic calorimeter to increase as much as possible the thermal resistance between the cell and the inner adiabatic shield of the calorimeter. It gives also a reliable calculation of the heat capacity of the cell and the comparison copper block which accommodates several CSPRTs. With this new system the reproducibility of metallic-sealed cell was found to be 0.7 mK as described below. reproducibility of metallic-sealed cells is found to be less than 0.7 mK.

  7. Die Arbeitswelt des Epigraphikers. Historische Hilfswissenschaft und ihre Bedeutung für Geschichte und Wissenschaft – ein römischer Erfahrungsbericht

    Directory of Open Access Journals (Sweden)

    Paul Sebastian Moos

    2012-05-01

    Full Text Available The column „Blick in die Historikerwerkstatt“ (A Glance into the Historian’s Workshop brings us on a journey to Germany’s oldest historical institute abroad, the German Historical Institute (DHI, in Rome, Italy. Since the institute was founded in 1888, historians have been actively at work, researching the history and development of German-Italian relations. Dr. Eberhard J. Nikitsch with the support of his student assistant Paul Sebastian Moos carries out intercultural research, working especially with epigraphic sources. In their report „Die Arbeitswelt des Epigraphikers. Historische Hilfswissenschaft und ihre Bedeutung für Geschichte und Wissenschaft – ein römischer Erfahrungsbericht“ (The Working World of the Epigrapher. The Historical Auxiliary Sciences and Their Significance for Historical and Academic Studies – a Roman Experience Report, the two historians outline their work, describe the various steps an epigrapher goes through, and locate their auxiliary science within modern historical and cultural studies. This report not only underlines the tremendous significance that is assigned to the study of inscriptions, but also provides the reader with an informative overview of the working environment of an epigrapher at the German Historical Institute in Rome.

  8. The Water Reuse project: Sustainable waste water re-use technologies for irrigated land in NIS and southern European states; project overview and results.

    Science.gov (United States)

    van den Elsen, E.; Doerr, S.; Ritsema, C. J.

    2009-04-01

    In irrigated areas in the New Independent States (NIS) and southern European States, inefficient use of conventional water resources occurs through incomplete wetting of soils, which causes accelerated runoff and preferential flow, and also through excessive evaporation associated with unhindered capillary rise. Furthermore, a largely unexploited potential exists to save conventional irrigation water by supplementation with organic-rich waste water, which, if used appropriately, can also lead to improvements to soil physical properties and soil nutrient and organic matter content. This project aims to (a) reduce irrigation water losses by developing, evaluating and promoting techniques that improve the wetting properties of soils, and (b) investigate the use of organic-rich waste water as a non-conventional water resource in irrigation and, in addition, as a tool in improving soil physical properties and soil nutrient and organic matter content. Key activities include (i) identifying, for the NIS and southern European partner countries, the soil type/land use combinations, for which the above approaches are expected to be most effective and their implementation most feasible, using physical and socio-economic research methods, and (ii) examining the water saving potential, physical, biological and chemical effects on soils of the above approaches, and also their impact on performance. Expected outputs include techniques for sustainable improvements in soil wettability management as a novel approach in water saving, detailed evaluation of the prospects and effects of using supplemental organic-rich waste waters in irrigation, an advanced process-based numerical hydrological model, fully adapted to quantify and upscale resulting water savings and nutrient and potential contaminant fluxes for irrigated areas, and identification of suitable areas in the NIS and Mediterranean (in soil, land use, legislative and socio-economic terms) for implementation.

  9. Composition and temperature dependent electronic structures of NiS2 -xSex alloys: First-principles dynamical mean-field theory approach

    Science.gov (United States)

    Moon, Chang-Youn; Kang, Hanhim; Jang, Bo Gyu; Shim, Ji Hoon

    2015-12-01

    We investigate the evolution of the electronic structure of NiS2 -xSex alloys with varying temperature and composition x by using the combined approach of density-functional theory and dynamical mean-field theory. Adopting realistic alloy structures containing S and Se dimers, we map their electronic correlation strength on the phase diagram and observe the metal-insulator transition (MIT) at the composition x =0.5 , which is consistent with the experimental measurements. The temperature dependence of the local magnetic susceptibility is found to show a typical Curie-Weiss-like behavior in the insulating phase while it shows a constant Pauli-like behavior in the metallic phase. A comparison of the electronic structures for NiS2 and NiSe2 in different lattice structures suggests that the MIT in this alloy system can be classified as of bandwidth-control type, where the change in the hybridization strength between Ni d and chalcogen p orbitals is the most important parameter.

  10. Prevalence and clinical significance of incidental cardiac findings in non-ECG-gated chest CT scans; Praevalenz und klinische Bedeutung inzidenteller Herzbefunde im nicht EKG-getriggerten Thorax-CT

    Energy Technology Data Exchange (ETDEWEB)

    Quentin, M.; Kroepil, P.; Lanzman, R.S.; Blondin, D.; Miese, F.; Scherer, A. [Heinrich-Heine-Universitaet Duesseldorf, Institut fuer Radiologie, Duesseldorf (Germany); Steiner, S. [Klinikum der Heinrich-Heine-Universitaet Duesseldorf, Klinik fuer Kardiologie, Pneumologie und Angiologie, Duesseldorf (Germany); Choy, G.; Abbara, S. [Massachusetts General Hospital, Harvard Medical School, Cardiovascular Imaging Section, Boston (United States)

    2011-01-15

    The purpose of this study was to evaluate the prevalence and clinical significance of incidental cardiac findings in non-ECG-gated chest CT. Non-ECG-gated chest CT examinations of 300 patients were retrospectively analyzed for incidental cardiac findings. Subsequently, these findings were evaluated for their clinical relevance by a cardiologist. A total of 107 out of 300 examined patients had 174 incidental cardiac findings including coronary calcification (90), aortic/mitral valve calcification (42), iatrogenic changes (23), pericardial effusion (6), dilatation of the heart (4), myocardial changes (3), thrombus in the left ventricle (2), constrictive pericarditis (2) and atrial myxoma (1). Of the cardiac findings 51% were described in the written report and in 53 out of the 107 patients the cardiac findings were unknown. Newly detected incidental findings from 8 patients were rated as clinically significant: pericardial effusion (4), constrictive pericarditis (1), thrombus in the left ventricle (1), atrial myxoma (1) and dilatation of the heart (1). Incidental cardiac findings are frequent in non-ECG-gated chest CT and may have a high clinical relevance. (orig.) [German] Ziel dieser Studie war es, die Praevalenz und klinische Bedeutung inzidenteller Herzbefunde im nicht EKG-getriggerten Thorax-CT ohne primaer kardiale Fragestellung zu evaluieren. Dreihundert nicht EKG-getriggerte Thorax-CT-Untersuchungen wurden retrospektiv bzgl. inzidenteller Herzbefunde analysiert. Die klinische Bedeutung wurde von einem Kardiologen bewertet. Von 300 Patienten hatten 107 insgesamt 174 Herzbefunde: Koronarsklerose (90), Aorten-/Mitralklappenverkalkung (42), iatrogene Veraenderungen (23), Perikarderguss (6), Herzvergroesserung (4), Myokardpathologien (3), Perikardverkalkungen (2), Thrombus im linken Ventrikel (2) und Myxom (1). Im radiologischen Bericht wurden 51% aller Herzbefunde beschrieben. Bei 53 der 107 Patienten mit Herzbefund waren diese klinisch nicht bekannt. Als

  11. Bilateral Comparison of 1 V and 10 V Standards between the NIS (Egypt) and the BIPM, August to September 2014 (part of the ongoing BIPM key comparison BIPM.EM-K11.a and b)

    Science.gov (United States)

    Solve, S.; Chayramy, R.; Stock, M.; Abdel Mageed, Hala M.; Aladdin, Omar M.; Raouf, M. Helmy A.

    2015-01-01

    As part of the ongoing BIPM key comparison BIPM.EM-K11.a and b, a comparison of the 1 V and 10 V voltage reference standards of the BIPM and the National Institute for Standards (NIS), Giza, Egypt, was carried out from August to September 2014. Two BIPM Zener diode-based travelling standards (Fluke 732B), BIPMB (ZB) and BIPMC (ZC), were transported as hand luggage on board an airplane to NIS and back to BIPM. At NIS, the reference standard for DC voltage is a Josephson Voltage Standard. The output EMF (Electromotive Force) of each travelling standard was measured by direct comparison with the primary standard. At the BIPM, the travelling standards were calibrated, before and after the measurements at NIS, with the Josephson Voltage Standard. Results of all measurements were corrected for the dependence of the output voltages of the Zener standards on internal temperature and ambient atmospheric pressure. The final result of the comparison is presented as the difference between the values assigned to DC voltage standards by NIS, at the level of 1.018 V and 10 V, at NIS, UNIS, and those assigned by the BIPM, at the BIPM, UBIPM, at the reference date of the 7 September 2014. UNIS - UBIPM = 0.09 µV uc = 0.08 µV, at 1 V UNIS - UBIPM = 0.22 µV uc = 0.14 µV, at 10 V where uc is the combined standard uncertainty associated with the measured difference, including the uncertainty of the representation of the volt at the BIPM and at NIS, based on KJ-90, and the uncertainty related to the comparison. This is a satisfactory result. The comparison result shows that the voltage standards maintained by NIS and the BIPM were equivalent, within their stated standard uncertainties, on the mean date of the comparison. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCEM

  12. Combination therapy and evaluation of therapeutic effect in hepatocellular carcinoma cell using triple reporter genes; containing for NIS, HSV1-sr39tk and GFP

    Energy Technology Data Exchange (ETDEWEB)

    Lee, You La; Lee, Yong Jin; Ahn, Sohn Joo; Ahn, Byeong Cheol; Lee, Sang Woo; Yoo, Jeong Soo; Lee, Jae Tae [Kyungpook National University, Daegu (Korea, Republic of)

    2007-07-01

    To identify therapeutic effect after combine Sodium Iodine Symporter (NIS) and Mutant Herpes-simplex virus type 1 sr39tk (HSV1-sr39tk) expression in hepatocellular carcinoma cell, we transfected triple gene and investigated the properties of these gene ability in hepatocellular carcinoma cell line. After making vector with gene encoding a fusion protein comprised of HSV1-sr39tk and green florescence protein (GFP), to make triple reporter genes NIS gene was further fused to the vector using IRES vector. The vector expressing triple reporter gene was transfected to the Huh-7 cell line using liposome. Functions of hNIS and HSV1-sr39tk expression were confirmed by radio iodine uptake with and without perchlorate and [3H]-penciclovir (3-H PCV) uptake, respectively. To evaluate therapeutic effect in vitro, GCV and I-131 was treated in Huh-7/NTG cell and dual therapy performed. An animal imaging acquired using Optix and microPET in vivo. I-125 uptake was increased up to 100-fold compare to that of non-transfected cells. The transfected cell accumulated H-3 PCV up to 53 times higher at 2 hour than that of non-transfected cells. With fluorescence microscopy, green fluorescence was detected in the transfected cell. In cytotoxic studies, the cell viability of Huh-7/NTG cell was decreased to 41 % of control cell at 10ug/ml GCV concentrations. The survival rate of the Huh-7/NTG cell treated with I-131 decreased up to 16%. In I-131 and GCV dual therapy, Huh-7/NTG cell survival rate decreased up to 4%. In animal studies, Huh-7/NTG tumors showed higher uptake of 18F-FHBG and I-124 than Huh-7 tumors. GFP signal is also higher in Huh-7/NTG tumor than control. We successfully constructed a vector with delivery two therapeutic genes and one reporter gene and transfected the vector to a Huh-7 cell. The hepatocellular carcinoma cell transfected with the vector can be treated with GCV and I-131. The effect of dual gene therapy could be easily assessed by the optical reporter gene imaging.

  13. „Ne, das kann ich besser!“ Umfang und Bedeutung der Contemporary TV Drama Serie The Mentalist für FanfictionautorInnen

    Directory of Open Access Journals (Sweden)

    Julia Elena Goldmann

    2015-07-01

    Full Text Available Einzelgänger und Außenseiter, die sich durch exzessives Konsumverhalten und extensives Trivialwissen um ein populärkulturelles Produkt auszeichnen – auch heute ist das Bild der Fans noch stark von Stereotypen geprägt. Meistens wird Fantum jedoch nicht mit Aktivität oder gar Kreativität gleichgesetzt. Viele Fans sind aber genau das: aktive ProduzentInnen von kulturellem Kapital. Dieser Artikel fokussiert eine derartige Fanaktivität: die Produktion von Fan Fiction. Darunter versteht man Fan-generierte, fiktionale Geschichten, die Charaktere sowie bestimmte Handlungselemente eines bestimmten (populärkulturellen Ausgangsproduktes – hier: die Serie The Mentalist – beinhalten, und heute auf entsprechenden Internetseiten gepostet werden. Dieser Artikel beschäftigt sich mit Bedingungen sowie Motivationen für die Produktion von deutschsprachiger Fan Fiction und der anschließenden Veröffentlichung derselben auf der Seite www.fanfiktion.de. Es wird gezeigt, dass die AutorInnen derartiger Texte, die eine immense Bandbreite aufweisen, sehr organisiert vorgehen. Des Weiteren wird die Bedeutung der Austauschund Review-Möglichkeiten auf den Fan Fiction Websites hervorgehoben, die sehr zentral für die interviewten fünf AutorInnen ist. English Abstract: Loners and outsiders, who can be distinguished through excessive consumption of and the knowledge of trivia around a specific cultural product as well as obsessive consumerism of said product – even today the image of fans is a highly stereotyped one. Usually, the reputation of a dedicated fan is not associated with an active, creative producer of cultural capital. In reality, most of them are though – a fact that can easily be shown by a single Google search. This article focuses one form of such fan-productivity: the creation of fan fiction. Fan fictions are user-generated, fictional stories which feature characters of the preferred, popular cultural fan object – here: the The

  14. EPIDEMIOLOGICAL - DEMOGRAPHIC CHARACTERISTIC OF SUICIDE ATTEMPTS IN ADOLESCENS TREATED AT THE INSTITUTE FOR MENTAL HEALTH IN NIS IN PERIOD OF 1999-2003

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    Ljubomir Milosavljevic

    2004-07-01

    Full Text Available The topic of this work is an epidemiological research of the suicide attempts of adolescents treated at the Institute for Mental Health Nis. The investigation comprises the period from 1999 up to 2003 year. The number of adolescents suicide attempts is increasing, and it is the highest one in 2003 year. Suicide attempt is most frequent with elderly female adolescents aged 17. A suicide attempt is preceded with manifestation in a form of mood disturbance in the scope of reactive situations. A dysfunctional family is the suicidal adolescent’s framework within which he moves while as, a means for the attempt, benzodiazepin’s group of medicaments is chosen by him.

  15. The Department of Baltic Philology (1921–1940 established by Jānis Endzelīns at the University of Latvia

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    Sarma Kļaviņa

    2014-06-01

    Full Text Available The article is devoted to the history of the Department of Baltic Philology of the Faculty of Philology and Philosophy at the University of Latvia. The department was established in the academic year of 1920/1921 by professor Jānis Endzelīns, who also acted as head of the department throughout its existence. Using the documents available at the Latvian State Historical Archives and the Museum of the University of Latvia, as well as published memories, the article provides a characterization of the establishment process of this department as an unprecedented one among the universities around the globe. The article also describes study programmes and their development, students and graduates, academic personnel, international relations of the department and its reputation.

  16. Mechanisms and rates of proton transfer to coordinated carboxydithioates: studies on [Ni(S2CR){PhP(CH2CH2PPh2)2}](+) (R = Me, Et, Bu(n) or Ph).

    Science.gov (United States)

    Alwaaly, Ahmed; Clegg, William; Henderson, Richard A; Probert, Michael R; Waddell, Paul G

    2015-02-21

    The complexes [Ni(S2CR)(triphos)]BPh4 (R = Me, Et, Bu(n) or Ph; triphos = PhP{CH2CH2PPh2}2) have been prepared and characterised. X-ray crystallography (for R = Et, Ph, C6H4Me-4, C6H4OMe-4 and C6H4Cl-4) shows that the geometry of the five-coordinate nickel in the cation is best described as distorted trigonal bipyramidal, containing a bidentate carboxydithioate ligand with the two sulfur atoms spanning axial and equatorial sites, the other axial site being occupied by the central phosphorus of triphos. The reactions of [Ni(S2CR)(triphos)](+) with mixtures of HCl and Cl(-) in MeCN to form equilibrium solutions containing [Ni(SH(S)CR)(triphos)](2+) have been studied using stopped-flow spectrophotometry. The kinetics show that proton transfer is slower than the diffusion-controlled limit and involves at least two coupled equilibria. The first step involves the rapid association between [Ni(S2CR)(triphos)](+) and HCl to form the hydrogen-bonded precursor, {[Ni(S2CR)(triphos)](+)HCl} (K) and this is followed by the intramolecular proton transfer (k) to produce [Ni(SH(S)CR)(triphos)](2+). In the reaction of [Ni(S2CMe)(triphos)](+) the rate law is consistent with the carboxydithioate ligand undergoing chelate ring-opening after protonation. It seems likely that chelate ring-opening occurs for all [Ni(S2CR)(triphos)](+), but only with [Ni(S2CMe)(triphos)](+) is the protonation step sufficiently fast that chelate ring-opening is rate-limiting. With all other systems, proton transfer is rate-limiting. DFT calculations indicate that protonation can occur at either sulfur atom, but only protonation at the equatorial sulfur results in chelate ring-opening. The ways in which protonation of either sulfur atom complicates the analyses and interpretation of the kinetics are discussed.

  17. Stalking: Klinische und forensische Bedeutung

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    Dreßing H

    2008-01-01

    Full Text Available Stalking ist in der Bevölkerung von Industrienationen ein weit verbreitetes Phänomen. Die Lebenszeitprävalenz beträgt über 11 %. Hinter den relativ gleichförmig erscheinenden Stalkingverhaltensweisen lassen sich unterschiedliche Täter-Opfer-Beziehungen und Motivationsstrukturen nachweisen. In der vorliegenden Arbeit werden wesentliche Aspekte der Tätertypologie sowie der psychischen Auswirkungen auf die Opfer diskutiert, sowie sich daraus ableitende und bisher noch kaum wahrgenommene Aufgaben der klinischen und forensischen Psychiatrie benannt. Da die Versorgung der Stalking-Opfer dringend verbessert werden muss, wird exemplarisch das Mannheimer Modellprojekt Stopp Stalking (MMSS vorgestellt.

  18. Juan del Encina (1469-1529 und die Bedeutung des Humanismus für die spanische Musik am Ende des 15. Jahrhunderts

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    Zywietz, Michael

    2002-12-01

    Full Text Available In recent decades studies on humanism have stressed the significance of the humanist movement in Spain during the 15th and 16th centuries and thus countered the dictum of "cultural belatedness" or the absence of a Spanish Renaissance. According to education and activity Encina must be called a humanist; moreover he personifies an ideal by combining the functions of poet and composer. In the Cancionero Musical de Palacio Encina is clearly the dominating composer. Since the cultivation of music at the court of the catholic kings in the second half of the 15th century was comparable to that at other European courts, it is surprising that Spanish composers took up the international style, dominated by franco-flemish composers, only in a very limited way, but established a separate national tradition in the field of secular vocal music. The striking simplicity of Spanish secular polyphony has often been interpreted as a deficiency and the lack of ability to adapt the compositional techniques of franco-flemish composers, who were taken as stylistic model; whereas the Spanish music historiography of the 19th and early 20th century emphasizing national aspects endeavored to show equivalents —nonexistent in such a way— to developments in Burgundy and Italy. Taking Encinas "Levanta Pascual" as example, the response to a concrete historical event (the fall of Grenada 1492 characteristic of a specific humanist conception will be illustrated.

    [de] In den jüngst vergangenen Jahrzehnten hat dir Humanismus-Forschung die Bedeutung von der humanistischen Bewegung in Spanien im 15. und 16. Jahrhundert hervorgehoben und ist so dem Diktum der „kulturellen Verspätung" und dem Fehlen einer Renaissance in Spanien entgegengetreten. Nach Ausbildung und Tätigkeit ist Encina als Humanist zu bezeichnen, zudem verkorpert er das Idealbild der Personalunion von Dichter und Komponist. Im

  19. Influence of socio-economic crisis on epidemiological characteristic of suicide in the region of Nis (southeastern part of Serbia, Yugoslavia).

    Science.gov (United States)

    Petrovich, B; Tiodorovich, B; Kocich, B; Cvetkovich, M; Blagojevich, L

    2001-01-01

    It is well known that gross social crises greatly influence the change in epidemiological features of suicide. The aim of this study is to determine whether the social-economic crisis in Yugoslavia influenced the change in epidemiological features of suicide in the region of Nis (southeastern Serbia). The material included death certificates for 1987-1999. The rates were calculated per 100,000 inhabitants (1991 Census) and standardization was performed by direct method (Segi's world population was used as standard population). Generally, trends for suicide rates in the region of Nis from 1987 to 1999 have decreasing tendency among both sexes. The average annual suicide rate in the region during the period 1987/1989 (relatively economically and politically stable) was 14.8 among males, and 6.8 among females. In 1999 (maximum influence of socio-economical and political crisis) suicide rate among males was 13.8 and among females it was 3.7. The decrease in suicide rate in females can be observed in all age groups, and in males in the age groups 15-29 and 50-64. During 1999, compared to 1987/1989, the increase in the number of suicides is perceived in the summer months (1999 -41.5%; 95% CI: 30.8-52.2%; 1987/ 1989 -23.8%; 95% CI: 18.9-28.7%), as well as the decrease of suicide on Monday (1987/1989 -21.2%; 95% CI: 16.2-26.1%; 1999 -9.8%; 95% CI: 3.4 16.2%). During 1999 the rate of suicides committed by fire arms increased (from 8.1 to 14.5%), while there was a decrease in poisoning, in both males (from 26.3 to 9.7%; p < 0.05) and females (from 39.1 to 10.0%; p < 0.05). During 1999 significant changes in epidemiological features of suicide were registered, compared to 1987/1989. These changes were probably enhanced by changed socio-economic factors (primarily war action and the bombing of Serbia, as well as the decline of standard of living and other aspects of economic and political crisis), which requires additional, more complete and thorough research.

  20. Earth-abundant NiS co-catalyst modified metal-free mpg-C3N4/CNT nanocomposites for highly efficient visible-light photocatalytic H2 evolution.

    Science.gov (United States)

    Zhong, Yongming; Yuan, Jielin; Wen, Jiuqing; Li, Xin; Xu, Yuehua; Liu, Wei; Zhang, Shengsen; Fang, Yueping

    2015-11-01

    In the present work, the earth-abundant NiS co-catalyst modified mesoporous graphite-like C3N4 (mpg-C3N4)/CNT nanocomposites were prepared via a two-step strategy: the sol-gel method and the direct precipitation process. The mpg-C3N4/CNT/NiS composite photocatalysts were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), UV-vis absorption spectroscopy, photoluminescence spectroscopy (PL), photoelectrochemical (PEC) and electrochemical impedance spectra (EIS) experiments. The photocatalytic H2-production activity over the composite catalysts was also evaluated by using an aqueous solution containing triethanolamine under visible light (λ≥ 420 nm). The results showed that the loading of earth-abundant NiS co-catalysts onto metal-free mpg-C3N4/CNT nanocomposites can remarkably enhance their photocatalytic H2-production activity. The optimal loading amount of NiS on metal-free mpg-C3N4/CNT nanocomposites was about 1 wt%. The as-obtained mpg-C3N4/CNT/1% NiS ternary composite photocatalyst exhibits the best H2-evolution activity with the highest rate of about 521 μmol g(-1) h(-1) under visible light (λ≥ 420 nm), which is almost 148 times that of a pure mpg-C3N4/CNT sample. The enhanced photocatalytic activity can be mainly attributed to the synergistic effect of effectively promoted separation of photo-generated electron-hole pairs and enhanced H2-evolution kinetics. The co-loading of nanocarbon materials and earth-abundant co-catalysts onto metal-free mpg-C3N4 photocatalysts offers great potential for practical applications in photocatalytic H2 evolution under visible light illumination.

  1. Allotment plan as a condition for sustainable development on the example of detailed regulation 'Stanko Vlasotinčanin' in Nis

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    Obradović Tanja

    2012-01-01

    Full Text Available In order to protect the environment and creation the conditions for a good and healthy life, the construction of buildings should be sustainable. It is essential that the entire process that includes planning, design and realization, be consistent with bioclimatic principles. Allotment plan should be an integral part of the planning process because it is an instrument to control the use of construction land and prevention the negative consequences that are created by uncontrolled action of the market. This paper analyzes the detailed regulation plan, 'Stanko Vlasotinčanin' in Nis with emphasis on the lack of plan allotment and (non application of bioclimatic principles in the planning. Performs a comparison with the detailed planning before 2003, ie. before the Law on planning and construction. Analyses the legislation relating to land use. Recommendations for amending the same, and the introduction of urban consolidation as a possible model of land development and implementation of spatial planning. It is concluded that it is necessary to undertake a number of different measures that are primarily related to the amendment and enforcement of legislation, the introduction of assessment of market value of land and the involvement and the willingness of experts and institutions for their implementation.

  2. The persistence of gender and racial disparities in vascular lower extremity amputation: an examination of HCUP-NIS data (2002-2011).

    Science.gov (United States)

    Lefebvre, Kristin M; Chevan, Julia

    2015-02-01

    The purpose of this study was to examine trends in racial and gender disparities in the severity of lower extremity amputation among individuals with peripheral artery disease (PAD) over the period of a decade (2002-2011). This is a longitudinal secondary analysis of data from the Healthcare Utilization Project Nationwide Inpatient Survey (HCUP-NIS) for the years 2002-2011. Level of amputation was determined from ICD-9-CM procedure and coded as either transfemoral (TF) or transtibial (TT). The main predictors were gender and race; covariates including age, race, income, insurance status and presence of vascular disease were incorporated as control variables in regression analysis. A total 121,587 cases of non-traumatic dysvascular amputations were identified. Female gender (odds ratio (OR) 1.35; 95% confidence interval (CI) 1.32, 1.39) and black race (OR 1.17; 95% CI 1.12, 1.23) are both significantly associated with increased odds for receiving TF amputation with no change in these odds over the decade of study. Other covariates with significant associations with TF amputation level include increased age (OR 1.03; 95% CI 0.99, 1.09), low income (OR 1.21; 95% CI 1.15, 1.27), Medicaid insurance (OR 1.36; 95% CI 1.29, 1.44), Medicare insurance (OR 1.27; 95% CI 1.21, 1.32), and cerebrovascular disease (OR 2.12; 95% CI 2.03, 2.23). In conclusion, although overall rates of amputation have decreased, disparities in level of amputation related to female gender and black race have not significantly changed over time. Higher-level amputation has significant consequences from a quality-of-life, medical and economic perspective.

  3. The Role of Amateur Football in Circular Migration Systems in South Africa Zur Bedeutung des Amateurfußballs für zirkuläre Migrationssysteme in Südafrika

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    Malte Steinbrink

    2010-01-01

    Full Text Available This article explores the significance of amateur football for the changing patterns of circular migration in post-Apartheid South Africa. Even after the end of Apartheid, the abolishment of the migrant labour system has not brought a decline of circular migration. The state-institutionalised system has merely been replaced by an informal system of translocal livelihood organisation. The new system fundamentally relies on social networks and complex rural-urban linkages. Mobile ways of life have evolved that can be classified as neither rural nor urban. Looking into these informal linkages can contribute to explaining the persistence of spatial and social disparities in “New South Africa”. This paper centres on an empirical, bi-local case study that traces the genesis of the socio-spatial linkages between a village in former Transkei and an informal settlement in Cape Town. The focus is on the relevance of football for the emergence and stabilisation of translocal network structures. Der vorliegende Beitrag untersucht die Bedeutung des Amateurfußballs für zirkuläre Migrationsmuster im heutigen Südafrika. Der Umfang zirkulärer Migration hat nach dem Ende der Apartheid und der Abschaffung des Wanderarbeitssystems nicht abgenommen, vielmehr wurde das institutionalisierte staatliche System durch ein informelles System translokaler Strategien zur Existenzsicherung ersetzt. Dieses neue System basiert auf sozialen Netzwerken und komplexen Land-Stadt-Verbindungen; die so entstandene mobile Lebensweise kann weder als urban noch als ländlich charakterisiert werden. Eine Untersuchung dieser informellen Verbindungen kann dazu beitragen, die Fortdauer räumlicher und sozialer Ungleichheiten im “Neuen Südafrika” zu erklären. Im Zentrum des Beitrags steht eine bilokale Fallstudie, in der der Autor die Spuren sozialräumlicher Verbindungen zwischen einem Dorf in der früheren Transkei und einer informellen Siedlung in Kapstadt zur

  4. hNIS基因转染介导Hela细胞移植瘤放射性核素显像和治疗的实验研究%The experimental study of radionuclide imaging and treatment of cervical cancer mediated by hNIS gene transfection

    Institute of Scientific and Technical Information of China (English)

    王浩炜; 汤亚莉; 石怡珍; 马孝明; 刘增礼

    2011-01-01

    Objective To explore the feasibility of imaging and treatment of cervical cancer xenograft model using 131I mediated by hNIS gene transfection. Methods The cervical cancer xenograft models were established with Hela-NIS( +) cells and Hela cells, respectively. Five Hela-NIS( +) xenograft models and five Hela xenograft models were dynamically imaged at 0.5, 1, 2, 4, 8, 16 and 20 h postinjection of 131I(7.4 MBq). Five Hela-NIS( +) xenograft models were imaged at 0. 5,1,2,4,8,16, 20 and 25 h postinjection of 99TcmO4-(11.1 MBq). Twenty Hela-NIS( +) cervical cancer xenograft models were randomly divided into four groups: Three 131I treating groups and one control group. The therapeutic effects of 131I at threelevels (74,111,148 MBq) were investigated following intraperitoneal injection. Results Hela-NIS( +)human cervical cancer xenografts were established successfully in nude mice. The Hela-NIS( +) xenografts significantly accumulated radioactivity after intraperitoneal injection of 131I, and the radioactivity was persistently present until 20 h postinjection, but Hela xenografts had no radioactive accumulation. The T/B value of the Hela-NIS( +) xenografts reached 17.34 at 8 h postinjection. The imaging with 99TcmO4- showed that the radioactivity was persistently present in Hela-NIS( +) xenografts for almost 25 h. The Hela-NIS( +)xenografts shrinked after 131I treatment. The inhibition ratios of tumor growth in 111 MBq and 148 MBq groups were both significantly higher than that of 74 MBq group (t: 2.74-5.75, P <0.05). Conclusions Hela-NIS( +) cervical cancer xenografts in nude mice could persistently accumulate 131I and 99TcmO4- and could be treated successfully with 131 I. 131 I treatment mediated by hNIS gene transfection could be a promising cancer treatment method.%目的 利用131I对转染hNIS基因的宫颈癌Hela-NIS(+)细胞移植瘤进行显像及治疗实验研究,评价hNIS基因转染介导131I治疗宫颈癌的可行性.方法 (1)利用Hela-NIS(+)细胞

  5. Public relations in risk communication: risk pr. The importance of public relations for risk communication; Public Relations in der Risikokommunikation: Risiko-PR. Die Bedeutung von Public Relations fuer die Risikokommunikation

    Energy Technology Data Exchange (ETDEWEB)

    Lehmann, K.

    2001-07-01

    Risks have become a central problem of our time, as is reflected in concepts like 'society at risk' and 'anti-technological attitude', in group protest against risks and against those who cause them, and last but not least in the critical attitude of the media. Against this background, organisations must needs enter the public discussion and be able to communicate professionally and convincingly in order to ensure their own success and further existence. The book describes the basic problems of risk research and risk communications and discusses inhowfar, and how, public relations strategies and instruments can help here. [German] Risiken werden verstaerkt zum Problem unserer Zeit. Das belegen nicht nur Begriffe wie 'Risikogesellschaft' und 'Technikfeindlichkeit', die in letzter Zeit an Bedeutung gewonnen haben, sondern auch und vor allem nachhaltige Proteste von engagierten Gruppierungen gegen Risiken und deren Verursacher oder auch die kritische Berichterstattung der Medien. Vor diesem Hintergrund ist es fuer Organisationen erforderlich, in die oeffentliche Auseinandersetzung um Risiken einzusteigen und hier professionell und ueberzeugend zu kommunizieren, um den Organisationserfolg und Organisationsbestand zu sichern. Die vorliegende Arbeit beschreibt die Grundprobleme der Risikoforschung und Risikokommunikation und diskutiert, ob und inwieweit Public Relations bei der Loesung dieser Probleme helfen koennen, da insbesondere Public Relations gezielt Strategien und Instrumente nutzen, um beispielsweise den Wissensstand der Oeffentlichkeit zu verbessern und den Dialog mit relevanten Teiloeffentlichkeiten zu foerdern. (orig.)

  6. What really separates us? Survey of attitudes of young people in the cities of Kikinda (Vojvodina, Nis, Bor (South and East Serbia, and Pristina, Pec, Prizren (Kosovo

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    Bašić Goran

    2014-01-01

    Full Text Available The results of the survey point to a high level of agreement among youth aged between 15 and 25 years of age, high school and college students, employed and unemployed youth, men and women in the cities of Pec, Pristina, Prizren in Kosovo, and Bor, Kikinda, and Nis in Serbia, on whether the question of mutual cooperation is burdened by prejudice and events from the past, and that the possibility and the quality of cooperation is influenced by the attitudes the receive in their primary social groups such as families and peers, and also by the attitudes they receive through education and media. At the same time, the possibilities to influence the social and political change aren’t big, and the youth have no desire to take the concrete civic or political initiatives. A certain perspective in cooperation the youth see in the European constellation and the good quality education. However, youth on both sides are not open to more intensive mutual meetings - the majority would not either host peers from the other communities gladly, nor they would respond to their invitation of hosting. They are not interested in cultural values of one another, but they do think respect of human rights should be guaranteed and they are ready for toleration of differences. The necessity of youth cooperation is important for overcoming the problems that citizens of Kosovo and Serbia are facing when it comes to exercising numerous rights, which from the perspective of individual freedoms collide with the concept of state reasons and "higher" interests. The regional stability depends on overcoming the issues that governments in Serbia and Kosovo have concerning Kosovo’s status, and also from setting a network of individual and group relations among the citizens. Youth should be the carriers of social and cultural changes. In the stated attitudes there is no direct objection to such processes, but fear of changes is clearly expressed because indirectly it can be

  7. {sup 99m}Tc reduces clonogenic survival after intracellular uptake in NIS positive cells in vitro more than {sup 131}I; {sup 99m}Tc reduziert nach intrazellulaerer Aufnahme in NIS-positiven Zellen in vitro das klonogene Ueberleben staerker als {sup 131}I

    Energy Technology Data Exchange (ETDEWEB)

    Wendisch, M.; Freudenberg, R.; Drechsel, J.; Runge, R.; Wunderlich, G.; Kotzerke, Joerg [Universitaetsklinikum Carl Gustav Carus Dresden - Technische Univ. Dresden (Germany). Klinik und Poliklinik fuer Nuklearmedizin

    2010-07-01

    In addition to gamma radiation of 140 keV {sup 99m}Tc emits during the transition to {sup 99}Tc electrons of low energy and tiny path-lengths. These Auger electrons cannot be utilized in diagnostic procedures. However, they were discussed frequently for therapeutic application. Hitherto proof of effect of the Auger electrons from {sup 99m}Tc is missing which is supplied now in an in vitro-system in comparison to beta-emitter {sup 131}I. The thyroid cell line PC CI3 (sodium iodide symporter (NIS)-positive) was incubated with {sup 131}I-sodium iodide ({sup 131}I) or {sup 99m}Tc-pertechnetate ({sup 99m}Tc) in presence or absence of perchlorate. For comparison the amount of radioactivity was adjusted to obtain the same dose from extracellular irradiation for both radionuclides. The colony forming assay detects the clonogenic cell survival as surviving fraction. In addition, intracellular radionuclide uptake was quantified. Dose effect curves were established for {sup 131}I and {sup 99m}Tc for variable extra- and intracellular distribution of the radioactivity. In presence of perchlorate no cellular uptake of radioactivity was detectable. Survival curves were largely comparable confirming the dosimetric calculations. In absence of perchlorate cellular radiotracer uptake varied from 1.39% ({sup 131}I) to 1.90% ({sup 99m}Tc). Effects on survival were twice for the beta-emitter and ten-fold higher for {sup 99m}Tc. Intracellular uptake of {sup 131}I and {sup 99m}Tc increases DNA-damage compared to strict extracellular radiotracer distribution which was demonstrated by means of colony forming assay. Increasing radiotoxicity from intracellular {sup 99m}Tc is explained most likely by increased dose deposition in cellular structures due to Auger- und conversion-electrons of low range and high local energy deposition. (orig.)

  8. BRAF mutation and its influence on function of NIS in differentiated thyroid cancer%BRAF基因突变及其对分化型甲状腺癌钠碘同向转运体功能影响的研究进展

    Institute of Scientific and Technical Information of China (English)

    王莎莎; 林岩松; 梁军; 李方

    2011-01-01

    目的:总结分化型甲状腺癌中鼠类肉瘤滤过性毒菌(V-raf)致癌同源体B1 (BRAF)基因突变与钠碘同向转运体(NIS)国内外研究进展,阐述BRAF和NIS基因结构表达与调控及BRAF基因突变对NIS功能的影响.方法:应用PubMed、Sciencedirect和万方检索系统,以“分化型甲状腺癌、钠碘同向转运体、BRAF、131I”为关键词,检索1998-2010年相关文献95篇.纳入标准:1)NIS结构与功能;2)NIS与分化型甲状腺癌的关系;3)BRAF结构与功能;4)BRAF突变与分化型甲状腺癌的关系;5)BRAF突变与NIS表达在分化型甲状腺癌中的关系.根据纳入标准分析文献23篇.结果:甲状腺癌131I治疗通过NIS介导.NIS的表达可以预测复发DTC131I的聚集和131I疗效评价.BRAF突变在PTC中可作为不良影响因子,影响PTC的发生、侵袭及预后.BRAF基因突变能引起NIS表达下降(20%~80%),病灶摄碘能力降低.NIS的表达水平在含有BRAF V600E突变的PTC中明显降低.结论:BRAF基因突变能引起NIS表达下降,降低病灶碘治疗疗效.因此,BRAF基因突变有望成为预测甲状腺癌放射性碘治疗疗效的指标.%OBJECTIVE:To review the recent advance on NIS and BRAF gene of differentiated thyroid cancer, to clarify the relationship between the two above genes in terms of structure, expression and regulation. METHODS: Keywords such as differentiated thyroid cancer,NIS,BRAF and 131 Ⅰ were used to search the full text database from PubMed, ScienceDi-rect and Wanfang database. Literatures were retrieved from 1998 to 2010,and 23 were finally analyzed according to the inclusion criteria as follows: 1) The structure and function of NIS ; 2) The relationship of NIS and differentiated thyroid cancer;3) The structure and function of BRAF; 4) The relationship of BRAF and differentiated thyroid cancer;5) The relationship of BRAF and NIS in differentiated thyroid cancer. RESULTS:131Ⅰ treatment of thyroid cancer is by NIS. The expression

  9. Βιβλιοκρισία του: W. HÖRANDNER – A. RHOBY (επιμ., Die kulturhistorische Bedeutung byzantinischer Epigramme. Akten des Internationalen Workshop (Wien, 1.-2. Dezember 2006

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    Ιωάννης ΒΑΣΣΗΣ

    2010-05-01

    Full Text Available βιβλιοκρισία του WOLFRAM HÖRANDNER – ANDREAS RHOBY (επιμ., Die kulturhistorische Bedeutung byzantinischer Epigramme. Akten des internationalen Workshop (Wien, 1.–2. Dezember 2006, [Österreichische Akademie der Wissenschaften. Philosophisch-historische Klasse. Denkschriften, 371. Band / Veröffentlichungen zur Byzanzforschung XIV], Wien 2008, σελ. 128 + 66 πίν.(ISBN 978-3-7001-6495-1

  10. [Jānis Keruss, Ineta Lipša, Inese Runce, Kaspars Zellis. Latvijas Universitātes Vēstures un filozofijas fakultātes vēsture padomju laikā: personības, struktūras, idejas (1944-1991)] / Kristine Wohlfart

    Index Scriptorium Estoniae

    Wohlfart, Kristine, 1968-

    2012-01-01

    Arvustus: Keruss, Jānis, Lipša, Ineta, Runce, Inese, Zellis, Kaspars. Latvijas Universitātes Vēstures un filozofijas fakultātes vēsture padomju laikā: personības, struktūras, idejas (1944-1991). (Riga. LU Akadēmiskais apgāds, 2010)

  11. [Jānis Keruss, Ineta Lipša, Inese Runce, Kaspars Zellis. Latvijas Universitātes Vēstures un filozofijas fakultātes vēsture padomju laikā: personības, struktūras, idejas (1944-1991)] / Kristine Wohlfart

    Index Scriptorium Estoniae

    Wohlfart, Kristine, 1968-

    2012-01-01

    Arvustus: Keruss, Jānis, Lipša, Ineta, Runce, Inese, Zellis, Kaspars. Latvijas Universitātes Vēstures un filozofijas fakultātes vēsture padomju laikā: personības, struktūras, idejas (1944-1991). (Riga. LU Akadēmiskais apgāds, 2010)

  12. Toxic chemicals and thyroid function: hard facts and lateral thinking.

    Science.gov (United States)

    Duntas, Leonidas H; Stathatos, Nikos

    2015-12-01

    Increasing quantities of evidence-based data incriminate a large number of environmental pollutants for toxic effects on the thyroid. Among the many chemical contaminants, halogenated organochlorines and pesticides variably affect the hypothalamic-pituitary-thyroid axis and disrupt thyroid function. PCBs and their metabolites and PBDEs bind to thyroid transport proteins, such as transthyretin, displace thyroxine, and disrupt thyroid function. Meanwhile, at the molecular level, PCB congeners may activate phosphorylation of Akt, p-Akt, and forkhead box O3a (FoxO3a) protein resulting in inhibition of the natrium/iodide symporter. Given therefore the growing concern developing around these multiple toxic chemicals today invading numerous environments and their long-term deleterious effects not only on the thyroid but also on general health, we strongly advocate their strict regulation and, moreover, their gradual reduction. A good degree of "lateral thinking", we feel, will lead to a use of chemicals that will enhance life while concurrently carefully protecting the environment.

  13. Die ambivalente Bedeutung des Urheberrechts für die Gestaltung des Internets als „Klangraum“. Eine kritische Betrachtung der urheberrechtsbezogenen Aneignung von Online-Angeboten am Beispiel Musik

    Directory of Open Access Journals (Sweden)

    Thomas Rakebrand

    2015-03-01

    Full Text Available Musik ist ein zentraler Gegenstand, mit denen sich Jugendliche und junge Erwachsene bei ihrer Identitätsbildung gezielt auseinandersetzen. Das Internet bietet ihnen dazu geeignete Strukturen, um über die Rezeption ihrer präferierten Musikinhalte hinaus kommunikativ, distributiv und produktiv-gestalterisch aktiv zu werden und sich dabei ihre Musik zu eigen zu machen. Mehr noch können die Subjekte den "Klangraum" Internet nach ihrer eigenen Facon kreieren und ihren identitätsrelevanten Sozialraum in die digitale Sphäre hinein erweitern. Doch der Aneignung von Online-Räumen sind auch Grenzen gesetzt. Insbesondere beim Thema Musik ist neben der technischen und strukturellen Rahmung der jeweiligen Online-Offerten das Urheberrecht bedeutend. Vor allem die Musikindustrie versucht seit geraumer Zeit die Interaktivität im Web 2.0 zu beschränken, respektive den Schöpfungsakt von MusikerInnen zu schützen. Es stellt sich jedoch die Frage, inwieweit dadurch auch die kreative Aneignung medialer Räume gehemmt wird. Anhand ausgewählter Untersuchungsergebnisse wird in diesem Beitrag aufgezeigt, dass die urheberrechtlichen Bestimmungen für die Gestaltung des "Klangraums" Internet eine ambivalente Bedeutung haben. Music plays a central role in young people’s identity formation. On the Internet, they find the appropriate structures to access their preferred music content as well as to communicate, distribute and productively manufacture this music to make it their own. Furthermore, the subjects of this study are able to transfer the Internet into a "sound space" of their exact preferences. By doing so, they extend their social space, which is important for their identity, into the digital area. However, the appropriation of online space is limited. Especially music does not only depend on technical und structural requirements of the online services, but also on copyright. The music industry has long tried to restrict the interactivity in Web 2

  14. Freges Unterscheidung Von Sinn Und Bedeutung

    Directory of Open Access Journals (Sweden)

    Wolfgang Spohn

    2012-01-01

    Full Text Available El objetivo de este artículo es ofrecer una introducción a la filosofía del lenguaje. Esto se hará de acuerdo con la siguiente pregunta: ¿Cuál es el significado de los nombres? Así que no tengo planes para hacer frente a todas las áreas de filosofía del lenguaje, sino que deseo impartir conoci- mientos básicos, especialmente, en la distinción de Frege entre sentido y referencia. La motivación de este enfoque se funda en la consideración de que sólo un ejemplo de la teoría de los nombres puede ser el principal problema y la pregunta clave de la filosofía del lenguaje. Por lo tanto, concentrarme en este tema ofrece un recorrido teórico de carácter intro - ductorio. Por otra parte, hay pocos análisis sistemáticos de introducción sobre el desarrollo de la teoría de los nombres de los inicios de la moderna filosofía del lenguaje a los enfoques modernos y contemporáneos, falencia que este trabajo trata de responder.

  15. Zinkstoffwechsel - Chemie, Physiologie, Pharmakologie und klinische Bedeutung

    Directory of Open Access Journals (Sweden)

    Zazgornik J

    2008-01-01

    Full Text Available Zink spielt eine wichtige Rolle im intrazellulären Stoffwechsel. Die mit Atomabsorptionsspektrophotometer gemessene Serum-Zinkkonzentration liegt bei 85–130 µg/dl (13–20 µmol/l. Zink ist in vielen Enzymen, welche an der Synthese von Proteinen des Bindegewebes, Nukleinsäuren, Hormonen und anderen beteiligt sind, vorhanden. Bei angeborenem oder erworbenem Zinkmangel kommen entzündliche Hautveränderungen, Durchfälle, Wachstumsstörungen, Hypogonadismus, Anämie sowie Geschmacksstörungen und Appetitlosigkeit vor. In der Zinkmangeltherapie werden vorwiegend Zinksulfat, Zinkchlorid und Zinkoxid verwendet. Eine orale Zinkergänzungsbehandlung verstärkt Heilungsprozesse der Haut, schützt Bindegewebe (Synovia, Knorpel vor Destruktionen und entzündlichen Veränderungen, verbessert sowohl die zelluläre als auch die humorale Abwehr, steigert das Wachstum sowie die sexuelle Reifung und reduziert bei Kleinkindern die Mortalität bei schweren Lungenentzündungen signifikant.

  16. Nisâ Sûresi 65. Âyete Dair Abdülmecîd-i Sîvâsî’nin (971/1049-1563/1639 Bilinmeyen Bir Risalesi

    Directory of Open Access Journals (Sweden)

    mehmet çiçek

    2011-09-01

    Full Text Available Osmanlı dönemi tefsir geleneğine dair yapılan çalışmalar, henüz beklenilen ve hedeflenen noktadan uzak görünmektedir. Bu makale, bir nebze de olsa mevcut duruma işaret etme ve “bilinmeyeni” ortaya çıkarma hedefini gütmektedir.  Abdülmecid-i Sivasi’ye ait Nisa suresi 65. Ayete dair risaleyi ele aldığımız bu makalede eser hakkında bilgi vermeye çalıştık. Değerlendirmelerimizi ise metod ve içerik olmak üzere iki açıdan ele aldık. Risale, söz konusu Nisâ suresi 60 ila 65. ayetlerin münafıklar hakkında indirildiğine dikkat çekmektedir. Ayrıca Zübeyr b. Avvam’ın sebeb-i nüzûlle ilgili rivâyetine bir cevap vermeyi hedeflemiştir, diyebiliriz. Buna ilaveten risalenin Bedir ehlinin üstünlüğüne dair hassasiyeti dikkate aldığı söylenebilir.

  17. Die Vulven der Chordeumatida: Merkmale von Taxonomischer Bedeutung (Diplopoda; Helminthomorpha)

    NARCIS (Netherlands)

    Kurnik, Ingrid; Thaler, Konrad

    1985-01-01

    A first survey covering 18 species from the eastern Alps (7 Craspedosomatidae, 2 Neoatractosomatidae, 4 Attemsiidae, 1 Mastigophorophyllidae, 2 Chordeumatidae, 2 Haaseidae) shows, that identification of chordeumatid females, difficult especially in a diverse fauna from peripheral characters alone,

  18. Die Bedeutung von Governance für das Steuerrecht

    Directory of Open Access Journals (Sweden)

    Tina Ehrke-Rabel

    2014-05-01

    Full Text Available ENGLISH: All over the world States struggle with guaranteeing effective taxation at a level playing field. The biggest tax gaps are not due to „simple“ tax fraud, but to tax evasion which in a globalized and „dematerialized“ world of economic activities taking place in the cloud is hardly detected by tax administrations. This lack of efficiency in the enforcement of tax law is not only based on the lack of State ́s resources but also on the fact that the instruments of enforcement have been adapted little to the changements in the way economic activities are effectuated. Concepts of good governance could offer new ideas for improving the enforcement rules. DEUTSCH: Eine gleichmäßige Besteuerung sicherzustellen fällt den Staaten heutzutage nicht leicht. Die größten Steuerausfälle werden nach überwiegender Auffassung nicht mehr durch einfache Steuerhinterziehungen, sondern durch Steuerumgehungen bewirkt, die in einer globalisierten und „entmaterialisierten“ (weil in der „Cloud“ stattfindenden Wirtschaftswelt vielfach vom Staat unentdeckt möglich sind. Die Vollzugsineffizienz liegt nicht nur an knappen staatlichen Ressourcen zur Sicherstellung der Kontrolle, sondern auch am Vollzugsinstrumentarium, das den geänderten Verhältnissen wirtschaftlicher Aktivitäten wenig angepasst wurde. Governance-Aspekte könnten Lösungsansätze bieten.

  19. Über die Bedeutung von Magnesium bei der Tumorgenese

    Directory of Open Access Journals (Sweden)

    Golf SW

    2001-01-01

    Full Text Available Magnesium (Mg und die Tumorgenese sind in funktioneller wie in struktureller Hinsicht vielseitig miteinander verknüpft. Die Tumorzelle ist befähigt, Mg zu Lasten der Mg-Pools des Organismus in überhöhter Konzentration zu speichern, auch wenn für den Organismus eine negative Mg-Bilanz vorliegt. Durch diese Veränderung der Mg-Verteilung wird die Zelle in die Lage versetzt, den erhöhten Enegiebedarf bei Zellwachstum, z.B. durch eine induzierte Proteinbiosynthese und RNA-/DNA-Biosynthese, sowie gesteigerte Transportvorgänge zu decken. Andererseits verlaufen zahlreiche Vorgänge bei der Protein-, RNA-/DNA-Synthese, bei der Signalentstehung und -Propagation, bei Teilen der Mitose (Umbau der nukleären Struktur, Meta- und Anaphase sowie bei der Metastase in einem akzelerierten Modus kalziumabhängig, was diese Reaktionen stark Mg-abhängig gestaltet. Ca verbleibt nur wenige Sekunden funktional und wird durch Influx in das endoplasmatische Retikulum (ER aus dem Zytosol eliminiert, wodurch die Prozesse gebremst oder sogar unterbrochen werden. Für den Rücktransport von Ca in die intrazellulären Speicher wird Mg benötigt; somit kann Mg auch als Inhibitor dieser Vorgänge betrachtet werden. Auch die biologische Zytostase z. B. durch alpha-Tumornekrosefaktor (alphaTNF verläuft Mg-abhängig, da eine gesteigerte Resistenz der Tumorzelle gegenüber alphaTNF bei Mg-Mangel besteht. In struktureller Hinsicht kommen Mg bedeutende Wirkungen bei der Tumorgenese zu. Klassisch sind die schützenden Effekte von Mg bei der durch kanzerogene Metalle, z.B. Arsen, Beryllium, Chrom, Blei, Quecksilber und Nickel, ausgelösten Tumorgenese. Eine Schutzwirkung tritt vor allem bei einem Ungleichgewicht zwischen dem kanzerogenen Metall und dem Mg-Status des Organismus ein. In analoger Weise sind auch die Stabilität von DNA und RNA sowie Reparaturmechanismen von DNA-Schäden nur in ausreichender Gegenwart von funktionellem Mg optimiert. Hinsichtlich der Immunkompetenz besteht auch Äquivalenz zwischen Mg-Mangel und Immunsuppression, die zu erleichterter Metastasierung führen kann. Bei den Membranparametern Cholesterin, Triglyceride und freie Fettsäuren, die neben einer Membranfunktion auch Signalwirkungen und Transportaufgaben aufweisen, werden durch einen Mg-Mangel sowie nach einer Zelltransformation in überraschender Übereinstimmung zahlreiche vergleichbare Modifikationen in qualitativer und quantitativer Hinsicht ausgelöst.

  20. Bedeutung von Pyritmineralen für die Grundwasserchemie

    Science.gov (United States)

    Wisotzky, Frank

    2015-06-01

    Pyrite formation and its distribution in different rocks in Germany are first reviewed, followed by a description of the pyrite oxidation processes and their effect on groundwater chemistry and on concrete attack, as well as impacts from lignite mining. In the last thematic block, lithotrophic nitrate reduction is presented with an example. This nitrate reduction is of great relevance in many aquifers for decreasing the problem of high nitrate concentrations in the groundwater and in drinking water. Overall the relevance of pyrite formation and pyrite oxidation with oxygen and nitrate is described in this overview article.

  1. Empathie in der Pädagogik : Theorien, Implikationen, Bedeutung, Umsetzung

    OpenAIRE

    Gassner, Burghard

    2006-01-01

    Die Arbeit über das Forschungsthema "Empathie in der Pädagogik" leitet mit folgenden allgemeinen Punkten ein: Stand der Empathieforschung, Definition der Empathie, Abgrenzung der Empathie von ähnlichen emotionalen Erscheinungen, Art der empathischen Prozesse und Auswirkungen einer mangelnden Empathiebereitschaft und Empathiefähigkeit.Mithilfe zweier neuer pragmatischer Kategorien für einen pädagogischen Rahmen wird unterschieden zwischen einer finalen Empathieform(im Mittelpunkt stehen konkre...

  2. Sympathikusaktivierung - Bedeutung für den Diabetiker

    Directory of Open Access Journals (Sweden)

    Wascher TC

    2004-01-01

    Full Text Available Sympathetic activation or, more adequate, autonomic imbalance has been found associated with cardiovascular and total mortality in the general population. It is frequently observed in hypertensive patients. The present mini-review summarizes the evidence that patients with the metabolic syndrome or type-2 diabetes in particular exhibit sympathetic imbalance also in the absence of manifest hypertension. These findings not only suggest that autonomic imbalance is a further feature of the metabolic syndrome but also emphasize the possible benefits of targeted treatment in this cardiovascular high-risk population.

  3. Evaluation and development of soil values for the pathway 'soil to plant'. Significance of mercury evaporation for the burden of plants; Ueberpruefung und Fortentwicklung der Bodenwerte fuer den Boden-Pflanze-Pfad. Teilbericht 2: Evaporation von Quecksilber aus kontaminierten Boeden und deren Bedeutung fuer die Hg-Aufnahme von Kulturpflanzen

    Energy Technology Data Exchange (ETDEWEB)

    Schlueter, K.; Gaeth, S.

    2001-10-01

    Ableitung von Pruef- und Massnahmenwerten bezueglich des Einwirkungspfades Boden/Pflanze die Bedeutung der Quecksilber-Evaporation im Hinblick auf die Hg-Kontamination von Nahrungs- bzw. Futtermittelpflanzen untersucht. Zu diesem Zweck wurde ein Gefaessversuch mit drei verschiedenen Boeden und unterschiedlicher Hg-Vorbelastung (Hintergrundbelastung, geogen und anthropogen belastet) und zwei verschiedenen Pflanzenarten (Petersilie und Spinat) im Labor unter definierten Randbedingungen in geschlossenen Lysimetern durchgefuehrt. Eine wurzelbuertige Hg-Aufnahme wurde dahingehend minimiert, indem die Pflanzen in handelsueblicher Kulturerde mit geringer Hg-Konzentration isoliert wuchsen und nur der umgebende Boden Hg evaporierte. Die Hg-Konzentrationen der Pflanzen betrugen auf der unbelasteten Variante (0,1 mg Hg/kg TS Boden) 0,15 (Spinat) mg/kg TS. Bei dem anthropogen belasteten Boden (111 mg Hg/kg TS Boden) wurden Werte von 2,0 und 2,6 mg/kg TS in der Pflanze gemessen. Eine vergleichbare Groessenordnung wurde auf der geogen belasteten Variante (34 mg Hg/kg TS Boden) mit 2,1 mg/kg TS (Spinat) und 0,44 mg/kg TS (Petersilie) erreicht. Versuche mit radioaktivem {sup 203}Hg zeigten, dass Teile des evaporierten Hg-Tracers in der Blattmasse, im Stengel und selbst in der Wurzel nachgewiesen werden konnte, was auf eine Translokation innerhalb der Pflanzen vom Blatt zur Wurzel schliessen laesst. Fuer den Vergleich der Untersuchungsergebnisse mit bestehenden Literaturdaten wurde im Rahmen einer Literaturstudie der aktuelle Kenntnisstand zur Hg-Evaporation des Bodens und zur Hg-Aufnahme von Pflanzen zusammengetragen. Der Vergleich zeigt, dass die gefundenen Hg-Konzentrationen mit Ergebnissen anderer Autoren im Einklang stehen. (orig.)

  4. Nuclear legislation in Central and Eastern Europe and the NIS

    CERN Document Server

    2000-01-01

    This publication examines the legislation and regulations governing the peaceful uses of nuclear energy in eastern European countries. It covers 11 countries from Central and Eastern Europe and 11 countries from the New Independent States. The chapters follow a systematic format making it easier for the reader to carry out research and compare information. This study will be updated regularly. Albania Kazakhstan Armenia Latvia Belarus Lithuania Bosnia and Herzegovina Poland Bulgaria Republic of Moldova Croatia Romania Czech Republic Russian Federation Estonia Slovak Republic Former Yugoslav Re

  5. Cloning of nis gene and Nisin purification from Lactococcus lactis ...

    African Journals Online (AJOL)

    user

    2014-12-31

    Dec 31, 2014 ... Author(s) agree that this article remains permanently open access under the terms of the ... 2005). Cultivation of pathogenic strains. Listeria monocytogenes, Escherichia coli, Pseudomonas aeruginosa, .... onto the top of separating gel where the comb was inserted. The ..... Wolf CE, Gibbons WR (1995).

  6. The Intercalibration of SOHO EIT, CDS-NIS, and TRACE

    Science.gov (United States)

    Brooks, David H.; Warren, Harry P.

    2006-05-01

    Using coordinated observations of a quiet coronal region, we study the intercalibration of the CDS and EIT instruments on board the Solar and Heliospheric Observatory (SOHO) and the Transition Region and Coronal Explorer (TRACE). We derive the differential emission measure (DEM) distribution from CDS spectral line intensities and convolve it with EIT and TRACE temperature response functions, calculated with the latest atomic data from the CHIANTI database, to predict count rates in their observing channels. We examine different analysis methods and briefly discuss some more advanced aspects of atomic modeling such as the density dependence of the ionization fractions. We investigate the implications for our study using data from the ADAS database. We find that our CDS DEM can predict the TRACE and EIT 171 and 195 Å channel count rates to within 25%. However, the accuracy of the predictions depends on the ionization fractions and elemental abundances used. The TRACE 284 Å and EIT 284 and 304 Å filter predictions do not agree well with the observations, even after taking the contribution from the optically thick He II 304 Å line to the TRACE 284 Å channel into account. The different CDS DEM solutions we derive using different ionization fractions produce fairly similar results: the majority of the CDS line intensities used are reproduced to within 20% with only around one-fifth reproduced to worse than 50%. However, the comparison provides us with further clues with which to explain the discrepancies found for some lines, and highlights the need for accurate equilibrium ionization balance calculations even at low density.

  7. Challenges/issues of NIS used in particle accelerator facilities

    Science.gov (United States)

    Faircloth, Dan

    2013-09-01

    High current, high duty cycle negative ion sources are an essential component of many high power particle accelerators. This talk gives an overview of the state-of-the-art sources used around the world. Volume, surface and charge exchange negative ion production processes are detailed. Cesiated magnetron and Penning surface plasma sources are discussed along with surface converter sources. Multicusp volume sources with filament and LaB6 cathodes are described before moving onto RF inductively coupled volume sources with internal and external antennas. The major challenges facing accelerator facilities are detailed. Beam current, source lifetime and reliability are the most pressing. The pros and cons of each source technology is discussed along with their development programs. The uncertainties and unknowns common to these sources are discussed. The dynamics of cesium surface coverage and the causes of source variability are still unknown. Minimizing beam emittance is essential to maximizing the transport of high current beams; space charge effects are very important. The basic physics of negative ion production is still not well understood, theoretical and experimental programs continue to improve this, but there are still many mysteries to be solved.

  8. Network and Information Sciences (NIS) International Technology Alliance (ITA)

    Science.gov (United States)

    2016-05-01

    networks. It has created new techniques for distributing stream ing and transaction oriented applications, ana lysing their performance, and improving the...phase mobility model, and verified the ana lytical results with a simulation study on a realistic wire less network model. A team from Imperial...LNCS 5444, pp. 437-456, 2009. [17] J. Lobo, J. Ma, A. Russo, Frank Le, "Declarative Distributed Computing", in Lecture Notes in Computer Science

  9. Verbitterte Frauen bewegen verletzte Männer. Wie aus Verben mit physischer Bedeutung Verben mit psychischer (Neben-)Bedeutung werden / Anni Silk

    Index Scriptorium Estoniae

    Silk, Anni

    2008-01-01

    Võrdlevalt analüüsitakse Lakoff/Johnsoni kognitivistliku metafooriteooria alusel selliseid eesti ja saksa verbe, mille esialgne tähendus seostub füüsilise maailmaga, kuid mida ülekantud tähenduses kasutatakse emotsiooniverbina

  10. Verbitterte Frauen bewegen verletzte Männer. Wie aus Verben mit physischer Bedeutung Verben mit psychischer (Neben-)Bedeutung werden / Anni Silk

    Index Scriptorium Estoniae

    Silk, Anni

    2008-01-01

    Võrdlevalt analüüsitakse Lakoff/Johnsoni kognitivistliku metafooriteooria alusel selliseid eesti ja saksa verbe, mille esialgne tähendus seostub füüsilise maailmaga, kuid mida ülekantud tähenduses kasutatakse emotsiooniverbina

  11. Diagnostic value of SPECT in bone scintigraphy; Bedeutung der SPECT bei der Knochenszintigraphie

    Energy Technology Data Exchange (ETDEWEB)

    Gratz, S.; Becker, W. [Goettingen Univ. (Germany). Abt. fuer Nuklearmedizin

    2000-05-01

    Single Photon Emission Computed Tomography (SPECT) reflects the realization of its ability to remove unwanted activity from bone structures with greater contrast. Especially in the spine SPECT improves the diagnostic accuracy compared with planar bone scintigraphy, because smaller structures of single vertebral bodies can be diagnosed with better anatomic resolution due to SPECT with consequently higher sensitivities and specificities. With SPECT, alterations of the lateral part of the vertebral body, pars interacticularis and smaller facet joints can be correctly diagnosed as spondylarthrotic degenerative alterations. In patients with suspected spine malignancies SPECT did not demonstrate to be a reliable instrument for diagnosing malignancy. We recommend to perform SPECT in case of patients with back pain and suspected spine pathologies seen on planar bone scans, since a correct diagnosis of especially benign spondylarthrotic spine lesions is possible with SPECT. With SPECT, a reduction of radiological examinations of 23% should be possible. (orig.) [German] Die Single-Photonenemissionscomputertomographie (SPECT) erlaubt bei der Knochenszintigraphie eine ueberlagerungsfreie Darstellung von Knochenstrukturen mit hoher Kontrastgenauigkeit. Insbesondere bei Wirbelsaeulenerkrankungen ermoeglicht SPECT einen deutlichen diagnostischen Zugewinn gegenueber planaren Aufnahmen, da kleinere Strukturen einzelner Wirbelkoerper aufgrund des hohen anatomischen Aufloesungsvermoegens mit SPECT sehr sensitiv und spezifisch dargestellt werden. Veraenderungen, die sich auf den lateralen Anteil des Wirbelkoerpers, die Pars interarticularis und die kleinen Facettengelenke projizieren, koennen mit SPECT als spondylarthrotisch degenerative Laesionen eingestuft werden. Zwingende SPECT-szintigraphische Kriterien, die eine Laesion als eindeutig maligne nachweisen, gibt es dagegen nicht. Wir denken, dass SPECT bei allen Patienten mit Rueckenschmerzen und planarszintigraphisch suspekten Wirbelsaeulenveraenderungen durchgefuehrt werden sollte, da insbesondere bei benignen spondylarthrotischen Veraenderungen eine Artdiagnose moeglich ist. Dadurch duerfte eine Reduktion radiologischer Untersuchungen von 23% realisierbar sein. (orig.)

  12. Die Bedeutung des instrumentalen Spiels im Höllenakt aus Rameaus Castor et Pollux

    Directory of Open Access Journals (Sweden)

    Büttner, Fred

    2013-12-01

    Full Text Available In modern Music History the continuity of instrumental playing gets increasingly broken up and changes into discontinuity – a process which, in the works of the Viennese Classic, culminates in a compositional mindset that brings the continuous instrumental fl ow and its abrupt break-up to ideal balance. A significant stadium in this development is formed by the music of "Opera buffa" as new genre in the first half of the eighteenth century, as it is represented by Pergolesi’s Serva padrona. On the other hand the French contribution, which makes itself felt with Rameau’s "Tragédies en musique", should not be neglected. A detailed study of the Hell Act from Castor et Pollux shows that also in the works of Rameau instrumental playing, even if it is able to realize, with its at times disquieting motivity, once again the old continuity of instrumental music, gets repeatedly stroken by discontinuity, in which the exciting actions on the stage find their musical expression.[de] In der neueren Musikgeschichte wird das Kontinuum des instrumentalen Spiels zunehmend aufgebrochen und in Diskontinuität verwandelt – ein Vorgang, der mit dem Schaffen der Wiener Klassik in einer kompositorischen Faktur gipfelt, in der die fortlaufende Spielbewegung im Taktsystem und deren abruptes Aufbrechen zu idealem Ausgleich gebracht werden. Eine wesentliche Station auf diesem Entwicklungsgang bildet, wie Thrasybulos Georgiades anschaulich gezeigt hat, die Musik der "Opera buffa" als neuer Gattung in der ersten Hälfte des 18. Jahrhunderts, wie sie namentlich durch Pergolesis Serva padrona vertreten wird. Darüber sollte man jedoch den französischen Anteil nicht vernachlässigen, der sich in Rameaus "Tragédies en musique" eindrucksvoll zu Wort meldet. Eine Betrachtung des Höllenakts aus Castor et Pollux macht deutlich, dass auch bei Rameau das instrumentale Spiel, obwohl es mit seiner zuweilen beunruhigenden Motorik noch einmal das alte Kontinuum der Instrumentalmusik realisieren kann, andererseits immer wieder von einer Diskontinuität erfasst wird, in der sich das aufregende Bühnengeschehen musikalisch niederschlägt. [es] La importancia de la música instrumental en el acto del Infierno de la ópera Cástor y Pólux de Rameau La continuidad de la música instrumental –en la moderna Historia de la Música–, experimenta un creciente proceso de fragmentación que la transforma en discontinuidad. Precisamente, este proceso halla su culminación en la escritura compositiva de las óperas de los clásicos vieneses, en donde el fluir continuo del discurso musical articulado en un sistema de compases bien definido–, alcanza una relación ideal de equilibrio con sus respectivos momentos de pausa o interrupción. Un estadio importante en este desarrollo evolutivo –como ha demostrado Thrasybulos Georgiades– lo representa la música de la ópera bufa, como nuevo género de la primera mitad del siglo XVIII, tal y como se muestra en la Serva padrona de Pergolesi. No se debe desdeñar tampoco la contribución francesa, que emerge con todo su vigor expresivo en las tragédias en música de Rameau. El estudio detallado del Acto del infierno de la ópera Cástor y Pólux evidencia esta misma articulación del discurso instrumental en las obras de Rameau, aun dándose cuenta de que la antigua continuidad de la música instrumental (con su mecánica motora –en ocasiones, incluso inquietante–, se ve, por otro lado, frecuentemente afectada por una cierta discontinuidad, en la que la música refleja la trama de la escena, y construye los momentos de mayor dramatismo.

  13. Vorbereitung auf die Familienbildung mit donogener Insemination - die Bedeutung edukativer Gruppenseminare

    Directory of Open Access Journals (Sweden)

    Thorn P

    2006-01-01

    Full Text Available Der edukative Anteil von Beratung wird häufig vernachlässigt. Dieser Artikel berichtet über einen edukativen Gruppenansatz für die Vorbereitung von Patienten, die eine donogene Insemination in Deutschland beabsichtigen oder bereits in Behandlung sind. Die Struktur, der Ablauf und der Inhalt dieser Gruppenseminare sowie eine Zusammenfassung zweier Studien werden beschrieben. Diese Studien weisen auf, daß der edukative Ansatz und das Gruppensetting empfohlen werden können, um Selbstsicherheit im Umgang mit der donogenen Insemination und der Aufklärung von Kindern und Nahestehenden zu erlangen.

  14. Zur Bedeutung der muskuloskelettalen Belastungen beim endoprothetischen Gelenkersatz der Hüfte

    OpenAIRE

    Markus O Heller

    2011-01-01

    In the context of an ever increasing life expectancy as well as heightened demands of patients with respect to the function of a total hip arthroplasty (THA), it remains unclear whether and to which extent current success rates and high patient satisfaction with the procedure can be maintained in the future. The question being addressed here is how an understanding of the musculoskeletal loading conditions at the hip can help to ensure achieving optimal outcome of total hip arthroplasty under...

  15. Importance of diffusion imaging in liver metastases; Bedeutung der Diffusionsbildgebung bei Lebermetastasen

    Energy Technology Data Exchange (ETDEWEB)

    Riffel, P.; Schoenberg, S.O.; Krammer, J. [Medizinische Fakultaet Mannheim der Universitaet Heidelberg, Institut fuer Klinische Radiologie und Nuklearmedizin, Universitaetsmedizin Mannheim, Mannheim (Germany)

    2017-05-15

    Detection and characterization of focal liver lesions. Due to its excellent soft tissue contrast, the availability of liver-specific contrast agents and the possibility of functional imaging, magnetic resonance imaging (MRI) is the method of choice for the evaluation of focal liver lesions. Diffusion-weighted imaging (DWI) enables generation of functional information about the microstructure of a tissue besides morphological information. In the detection of focal liver lesions DWI shows a better detection rate compared to T2w sequences and a slightly poorer detection rate compared to dynamic T1w sequences. In principle, using DWI it is possible to distinguish malignant from benign liver lesions and also to detect a therapy response at an early stage. For both detection and characterization of focal liver lesions, DWI represents a promising alternative to the morphological sequences; however, a more detailed characterization with the use of further sequences should be carried out particularly for the characterization of solid benign lesions. For the assessment and prognosis of therapy response, DWI offers advantages compared to morphological sequences. For the detection of focal liver lesions DWI is in principle sufficient. After visual detection of a solid liver lesion a more detailed characterization should be carried out using further sequences (in particular dynamic T1w sequences). The DWI procedure should be used for the assessment and prognosis of a therapy response. (orig.) [German] Detektion und Charakterisierung fokaler Leberlaesionen. Die MRT ist aufgrund des exzellenten Weichteilkontrasts, der Verfuegbarkeit leberspezifischer Kontrastmittel und der Moeglichkeit funktioneller Bildgebung die Methode der Wahl zur Abklaerung fokaler Leberlaesionen. Die diffusionsgewichtete Bildgebung (''diffusion-weighted imaging'', DWI) ermoeglicht es, neben den rein morphologischen auch funktionelle Informationen ueber die Mikrostruktur eines Gewebes zu generieren. Bei der Detektion fokaler Leberlaesionen zeigt die DWI eine bessere Detektionsrate im Vergleich zu T2w-Sequenzen und eine etwas schlechtere Detektionsrate im Vergleich zu dynamischen T1w-Sequenzen. Prinzipiell ist es mit der DWI moeglich, maligne Leberlaesionen von benignen zu unterscheiden sowie ein Therapieansprechen fruehzeitig zu detektieren. Sowohl fuer die Detektion als auch fuer die Charakterisierung fokaler Leberlaesionen stellt die DWI eine vielversprechende Alternative zu den morphologischen Sequenzen dar. Insbesondere fuer die Charakterisierung solider benigner Laesionen sollte jedoch deren naehere Charakterisierung unter Zuhilfenahme weiterer Sequenzen erfolgen. Fuer die Beurteilung und die Prognose eines Therapieansprechens bietet die DWI Vorteile im Vergleich zu den rein morphologischen Sequenzen. Zur reinen Detektion fokaler Leberlaesionen ist die DWI prinzipiell ausreichend. Nach visueller Detektion einer soliden Leberlaesion sollte deren naehere Charakterisierung unter Zuhilfenahme weiterer Sequenzen (insbesondere dynamischer T1w-Sequenzen) erfolgen. Fuer die Beurteilung und die Prognose eines Therapieansprechens sollte die DWI herangezogen werden. (orig.)

  16. Zur Bedeutung von Michel Foucault für die heutige Psychiatrie

    NARCIS (Netherlands)

    Vandermeersch, P.M.G.P.

    1997-01-01

    M. Foucault´s book on the history of madness has mostly been received as an anti-psychiatric critique of the great confinement. Thus, the original meaning of the book has been discarded: a critique of the psychiatric practice from the point a view of history of science and philosophy of culture.

  17. Die Bedeutung des "Orbis Sensualium Pictus" fur Schulbucher im Kontext der Geschichte der Schule.

    Science.gov (United States)

    Michel, Gerhard

    1992-01-01

    Investigates the impact of Comenius' textbook "Orbis Sensualium Pictus" on eighteenth-century German textbooks. Examines his textbook theory and the structure and function of the book. Reports influence on the illustration of textbooks, function and structure of an introductory book, the correlation of verbal and real elements, and…

  18. Die Weichholzauen und deren Bedeutung für den Hochwasserschutz im Elbegebiet

    OpenAIRE

    2003-01-01

    Vor dem Hintergrund der Hochwässer des Jahres 2002 werden immer wieder Fragen laut, wie die Weichholzauen bezüglich der hydraulischhydrologischen Wirkungen zu beurteilen sind. Die folgenden Aussagen sollen versuchen, einige dieser Fragestellungen unter Bezugnahme auf die mittlere Elbe zu beantworten. Sicherlich ist es nicht möglich, in diesem Zusammenhang jeden Einzelaspekt ausreichend zu beleuchten, zumal sich auch die Autoren der ausgewerteten Quellen hinsichtlich eindeutiger Aussagen relat...

  19. Europäisches Bewusstsein: Zur Definition Eines Vielschichtigen Begriffes und Seiner Bildungstheoretischen Bedeutung

    Science.gov (United States)

    Jobst, Solvejg

    2005-11-01

    EUROPEAN CONSCIOUSNESS: TOWARDS DEFINING A COMPLEX CONCEPT AND ITS EDUCATIONAL SIGNIFICANCE - The present study aims at a definition of `European consciousness'. In particular, it draws on Henri Tajfel's theory of social identity as well as Roland Wakenhut's and Jutta Gallenmüller's moral determination of national consciousness. European consciousness is then defined as a sense of belonging which, depending on certain identification structures and social perspectives, can take such distinct forms of moral consciousness as `Eurocentrism', `European patriotism', or `reflective European consciousness'. Making reference to Wolfgang Klafki's notion of general education, it is finally argued that the emancipatory contribution of schooling to greater European integration consists in mediating precisely this last way of thinking.

  20. The importance of imaging methods in gallstone disease. Die Bedeutung bildgebender Verfahren beim Gallensteinleiden

    Energy Technology Data Exchange (ETDEWEB)

    Kersjes, W. (Institut fuer Klinische Strahlenkunde, Klinikum der Johannes-Gutenberg-Universitaet Mainz (Germany)); Thelen, M.

    1993-05-01

    The available surgical and non-surgical therapy options for treatment of gallstone disease are presented. Conventional cholecystectomy is regarded as standard therapy of symptomatic cholecystolithiasis. Other modes of therapy may be indicated under certain circumstances, depending on the results of imaging procedures. In this context conventional X-ray examination, oral and intravenous cholecystography, sonography, computed tomography, endoscopic retrograde cholangiography/cholecystography, and magnetic resonance imaging are discussed, and their influence on therapeutic decisions is explained. (orig.)

  1. Früherkennung der Schizophrenie und die Bedeutung für Verlauf und Outcome

    Directory of Open Access Journals (Sweden)

    Maurer K

    2007-01-01

    Full Text Available Sofern wir in der Lage sind, Personen mit einem Schizophrenierisiko früher als üblich zu erkennen, besteht auch die Chance, diese Personen früher zu behandeln. Früherkennung erfordert verschiedene Voraussetzungen, wie z. B. das Wissen um psychotische Erkrankungen in der Bevölkerung sowie niederschwellige Angebote der Frühintervention. Eine weitere Voraussetzung sind reliable und valide Methoden der Früherkennung. Dazu zählen akzeptierte und valide Kriteriensets sowie Früherkennungsinventare. Weitgehend akzeptierte Diagnosekriterien wurden bisher nur für sogenannte "Ultra-High-Risk"-Personen festgelegt. Darüber hinaus existieren mehrere Früherkennungsinstrumente, deren Validierung allerdings noch aussteht. Die mit der Früherkennung und Frühintervention verbundene Erwartung, durch Kürzung der Dauer der unbehandelten Psychose ("Duration of Untreated Psychosis", DUP oder der unbehandelten Erkrankung ("Duration of Untreated Illness", DUI Verlauf und Ausgang günstig zu beeinflussen, folgt aus dem meist bei Erstepisodenstichproben gefundenen negativen Zusammenhang von DUP und Outcome. Der Vorbehalt, dieser Zusammenhang sei durch Konfundierung, z. B. mit prämorbider Anpassung oder einer anderen, nicht direkt therapeutisch beeinflußbaren Variablen zu erklären, konnte durch statistische Kontrolle solcher Variablen weitgehend ausgeräumt werden. Doch der entscheidende Nachweis des Erfolgs der Frühintervention ist nur durch ein experimentelles (oder quasiexperimentelles Untersuchungsdesign zu leisten. Hierfür gibt es erste Hinweise in die erwünschte Richtung, doch sind die Ergebnisse – wegen zu geringer Fallzahlen und zu kurzer Beobachtungszeit – noch nicht ausreichend überzeugend. Erst wenn der experimentelle Nachweis der Wirksamkeit der Frühintervention auf den Krankheitsverlauf erfolgreich ist, läßt sich die weitere Intensivierung und Etablierung der Frühintervention rechtfertigen.

  2. Untersuchungen zur Bedeutung anthelminthischer Behandlungen bei der Auslösung von Symptomen einer larvalen Cyathostominose

    OpenAIRE

    Steinbach, Tanja

    2003-01-01

    Im Rahmen dieser Arbeit wird untersucht, ob bei Pferden durch die Gabe von Anthelminthika Symptome einer larvalen Cyathostominose ausgelöst werden können. Im Zentrum des Interesses stehen dabei die Anthelminthika Moxidectin und Fenbendazol, die aufgrund ihrer larviziden Wirksamkeit als Mittel der ersten Wahl für die kausale Therapie und Metaphylaxe der larvalen Cyathostominose angesehen werden. Der Versuch wird an 24 Ponyfohlen durchgeführt, die in die folgenden Gruppen unterteilt werden...

  3. Die Bedeutung der Umkreisquellen für Alexander von Humboldts südamerikanische Reise

    Directory of Open Access Journals (Sweden)

    Wolfgang Griep

    2005-04-01

    Full Text Available Article in German, Abstracts in English, German and Spanish. Contrary to popular opinion, Alexander von Humboldt had little time to make in-depth preparations and acquire thorough knowledge about his most important destination, the Spanish colonies in Central and South America. So he could study most of the travelogues written by his predecessors only after returning home. Humboldt’s belated study of literary sources, combined with the question how he made use of the huge amount of facts he found during many years’ work and at the same time succeeded in being acknowledged as an outstanding researcher, are of great importance for our understanding the significance of background information in Humboldt’s work. As it seems necessary as well as promising to enquire into Humboldt’s sources in detail, this article presents within the “Humboldt Digital Library” research project a preliminary investigation of the different sources Humboldt used for describing a limited section of his South America journey: the Orinoco river system.

  4. Importance of hydropower for the global power generation; Bedeutung der Wasserkraft fuer die weltweite Stromerzeugung

    Energy Technology Data Exchange (ETDEWEB)

    Schiffer, Hans-Wilhelm [World Energy Council, London (United Kingdom). World Energy Resources; RWE AG, Essen (Germany)

    2015-10-15

    The renewable energy sources have in the last ten years - not only in Germany, but also worldwide - can post disproportionately strong growth rates. This is especially true in the electricity production. Especially the new renewable energies have a stable, strong growth and gain as compared to the conventional generation ever more ground. Nevertheless, hydropower remains by far the most important source of renewable energy in electricity generation. An analysis shows that hydropower can make significant contributions to sustainable and climate-friendly energy supply by 2050, if it is possible to raise their still unused potential. [German] Die erneuerbaren Energien haben in den letzten zehn Jahren - nicht nur in Deutschland, sondern auch weltweit - ueberproportional starke Zuwachsraten verbuchen koennen. Dies gilt insbesondere in der Stromerzeugung. Gerade die neuen erneuerbaren Energien weisen ein bestaendiges, starkes Wachstum auf und gewinnen so gegenueber der konventionellen Erzeugung immer weiter an Boden. Trotzdem ist die Wasserkraft unveraendert die mit Abstand bedeutendste erneuerbare Energiequelle in der Stromerzeugung. Eine Analyse zeigt, dass die Wasserkraft bis 2050 signifikante Beitraege zu einer nachhaltigen und klimaschonenden Energieversorgung leisten kann, wenn es gelingt, ihre noch ungenutzen Potenziale zu heben.

  5. The impact of nuclear imaging on pediatric urology; Die Bedeutung nuklearmedizinischer Untersuchungsverfahren in der Kinderurologie

    Energy Technology Data Exchange (ETDEWEB)

    Zoeller, G. [Urologische Universitaetsklinik, Goettingen (Germany)

    2000-11-01

    Nuclear imaging has a key role in diagnosis and therapy in modern pediatric urology. We discuss the value and limitations of radionuclide studies (diuresis renogramm, DMSA, VCUG, MIBG scintigraphy) with special regard to characteristic pathologic entities in pediatric urology. (orig.) [German] Nuklearmedizinische Untersuchungsverfahren nehmen in der modernen Kinderurologie eine zentrale Stellung in der Diagnostik und Therapieplanung ein. In einer Uebersicht werden die Wertigkeit der verschiedenen Untersuchungsverfahren (Diureserenographie, DMSA, Isotopen-MCU, MIBG-Szintigraphie) bei typischen kinderurologischen Krankheitsbildern dargestellt und ihre Grenzen aufgezeigt. (orig.)

  6. Experimentelle Untersuchungen zur Bedeutung von Wachstums- und Gerinnungsfaktoren bei der Entstehung maligner Ergüsse

    OpenAIRE

    Blume, Lars-Fabian

    2010-01-01

    Etwa 15-20 % aller Tumorpatienten entwickeln im Verlauf ihrer Erkrankung einen pleuralen oder peritonealen Erguss. In Anbetracht der kurzen Überlebenszeit von im Mittel 20 Wochen ist bei der Therapie maligner Ergüsse die Beseitigung der durch den Erguss hervorgerufenen Symptome und Beschwerden das zentrale Ziel. Bisher gibt es keine befriedigende Behandlung maligner Ergüsse, da nur eine begrenzte Patientenzahl körperlich in der Lage ist, sich einem invasivem Eingriff mit abschließender Pleuro...

  7. Die Bedeutung von Krankheitsverarbeitungsprozessen für den Rehabilitationserfolg kardiologischer Patienten

    OpenAIRE

    Dörner, U. (Udo)

    2004-01-01

    Krankheitsverarbeitungsprozessen wird Einfluss auf den Reha-Erfolg, die Lebensqualität und die Überlebenszeit zugeschrieben. 54 kardiologische Rehabilitanden wurden viermal (Ende der Akutbehandlung, Reha-Beginn, Reha-Ende, 6-Monatskatamnese) zu Krankheitsverarbeitung, subjektiven Theorien, sozialer Unterstützung, Lebensqualität und Erwerbsfähigkeit befragt. Vor allem eine depressive Verarbeitung stand mit einer schlechteren Lebensqualität in Beziehung. Medizinische Variablen korrelierten kaum...

  8. Die Bedeutung von qualitativer Marktforschung in der Praxis der betrieblichen Marktforschung

    OpenAIRE

    Kaiser, Werner

    2004-01-01

    Der Autor definiert aus Sicht der betrieblichen Marktforschung qualitative und quantitative Marktforschung nicht als Gegensatz, sondern als geschlossene Einheit zweier sich ergänzender Forschungsbereiche. Seine nicht methoden-, sondern ergebnisorientierte Definition von quantitativer und qualitativer Marktforschung bildet beide als ineinander übergehendes Kontinuum ab. Da betriebliche Marktforschung in einem betriebswirtschaftlich orientierten Umfeld agiert, ist sie im Prinzip eher quantitati...

  9. Ökonomische Grundbildung für Erwachsene – Bedeutung, Forschungsstand, Desiderate

    OpenAIRE

    Weber, Birgit; Eik, Iris van; Maier, Petra

    2013-01-01

    Angesichts der defizitären Forschungslage in den Punkten Unklarheit über notwendiges Wissen und erforderliche Kompetenzen sowie einen geeigneten Bewertungsmaßstab, Relevanz für heterogene Zielgruppen und ihre Erreichbarkeit unter Berücksichtigung der Besonderheiten des Erwachsenenalters, Unübersichtlichkeit der Angebotslandschaft und Eigeninteressen der Anbieterseite bei fehlender Definition von Erfolgskriterien stellen sich mit Blick auf die ökonomische Grundbildung für Erwachsene insbesonde...

  10. Die Bedeutung der aktuellen Nierentumorklassifikation für Diagnostik und Therapie

    Directory of Open Access Journals (Sweden)

    Moch H

    2008-01-01

    Full Text Available In den letzten Jahren erweiterte sich das Verständnis zur Histogenese von Nierentumoren durch neue molekulare Erkenntnisse erheblich. Damit wurde es möglich, eine Klassifikation der Nierentumoren auf der Basis von molekularen Veränderungen vorzunehmen. Daneben wurden neue Tumortypen identifiziert, deren Kenntnis erheblichen Einfluss auf die Auswahl der Behandlungsstrategien haben kann. Bei zystischen Nierentumoren gibt es zum Beispiel neben Tumoren mit sehr guter Prognose auch hochmaligne Tumoren. Die charakteristischen molekularen Veränderungen sind einerseits für die Klassifikation der verschiedenen Nierentumoren relevant, andererseits können sie auch innerhalb der klarzelligen Nierenzellkarzinome ein potenzielles Ansprechen auf neue Medikamente vorhersagen. Die Kenntnis der molekularen Zielstrukturen bei Nierenkarzinomen ist die Grundlage für neue Therapien, die gegen spezifische Strukturen gerichtet sind. HIF- α-responsive Gene, z. B. VEGF, PDGF, TGFα, EGFR und Ca IX spielen dabei eine zentrale Rolle beim klarzelligen Nierenkarzinom.

  11. Wirbelsäulenchirurgische Verfahren und Bedeutung bei osteoporotischen Wirbelkörperfrakturen

    Directory of Open Access Journals (Sweden)

    Teuscher R

    2013-01-01

    Full Text Available Osteoporotische Wirbelbrüche sind häufig. Der Großteil ist gutartig mit einem selbstlimitierenden Verlauf. Allerdings sehen wir in der Wirbelsäulenchirurgie zunehmend auch die Problemfälle: persistierende Instabilität/ Pseudarthrose nach einer Fraktur, der langsam progressive Verlust der Haltung/Wirbelsäulenbalance als Folge mehrerer Wirbelbrüche und schließlich neurologische Komplikationen in Verbindung mit einer osteoporotischen Fraktur. Die Injektion von Knochenzement zur Stabilisierung von Wirbelfrakturen ist effizient und hat sich bewährt. Damit erreicht man eine Stabilisierung des Wirbels und eine sehr wirksame Schmerzkontrolle. Zusätzlich (und häufig zu wenig beachtet können damit ein weiteres Einsintern des Knochens verhindert und Folgekomplikationen so vermieden werden. Wo diese einfache minimalinvasive Technik nicht mehr genügt, sind offene Verfahren notwendig. Auch dabei wird eine kombinierte Technik angewendet: Die Stabilisierung erfolgt nach den gängigen wirbelsäulenchirurgischen Prinzipien, zur Verankerung der Implantate im osteoporotischen Knochen wird ebenfalls Knochenzement verwendet.

  12. The use of hydropower in South Tyrol; Wasserkraftnutzung in Suedtirol. Ausgangsvoraussetzungen, Bedeutung und Akteure

    Energy Technology Data Exchange (ETDEWEB)

    Berger, W. [Orizzonti, Verona (Italy)

    2007-12-03

    The Autonomous Province of Bolzano in the north of Italy is richly endowed with water ressources, which provided an essential basis for industrial development in the last century. Even today electricity production, exceeding consumption figures of the Province, is almost entirely based on hydropower. At the main river Adige and its tributaries there are currently about 850 hydropower plants in operation. Nearly 85% of the installed power are owned by only four electric utilities. The Region Trentino-Alto Adige shows a higher capacity per inhabitant and per surface of electricity generation from hydropower than Austria, internationally renowned for her exploitation of this ressource. (orig.)

  13. Identification of clinically relevant Trichosporon species = Identifizierung von Triochosporon-Arten mit klinischer Bedeutung

    NARCIS (Netherlands)

    Middelhoven, W.J.

    2003-01-01

    A dichotomous identification key to pathogenic species of the basisiomycetous genus Trichosporon Behrend is provided. It is based on growth tests with carbon sources not traditionally used in yeast taxonomy, viz. uric acid, ethylamine, l-4-hydroxyproline, tyramine and L-phenylalanine as sources of c

  14. Zur Bedeutung von Michel Foucault für die heutige Psychiatrie

    NARCIS (Netherlands)

    Vandermeersch, P.M.G.P.

    1997-01-01

    M. Foucault´s book on the history of madness has mostly been received as an anti-psychiatric critique of the great confinement. Thus, the original meaning of the book has been discarded: a critique of the psychiatric practice from the point a view of history of science and philosophy of culture. Thi

  15. Bedeutung von Stress und Depression bei chronisch entzündlichen Darmerkrankungen

    Directory of Open Access Journals (Sweden)

    Moser G

    2005-01-01

    Full Text Available Der Einfluß von psychischem Stress auf den klinischen Verlauf von chronisch entzündlichen Darmerkrankungen wird zunehmend beachtet, obwohl die Rolle einzelner Lebensereignisse als Ursache für eine Krankheitsaktivierung kontrovers gesehen wird. Prospektive Studien zeigten widersprüchliche Ergebnisse bezüglich einschneidender Lebensereignisse, es wurde aber ein Zusammenhang zwischen subjektiv empfundenem chronischem (Alltags-Stress und der Krankheitsaktivierung von Colitis ulcerosa gefunden. Es konnte auch gezeigt werden, daß eine depressive Stimmung einen negativen Effekt auf die Krankheitsaktivität des Morbus Crohn haben kann: Betroffene haben nach einer Akutphase der Erkrankung und nach Erreichen der Remission ein früheres Auftreten einer neuerlichen entzündlichen Krankheitsaktivität, wenn eine depressive Stimmungslage vorliegt. Stress und Depression stellen daher ein Risiko für wiederkehrende oder chronische Krankheitsaktivität der chronisch entzündlichen Darmerkrankungen dar. Dieser Effekt kann über die regulatorische Rückkopplung zwischen ZNS, endokrinem und Immunsystem wirken und zur Beeinträchtigung der intestinalen Barriere führen. Für die klinische Betreuung der PatientInnen muß bedacht werden, daß soziale Unterstützung und eine integrierte psychische Betreuung sich positiv auf das Stressempfinden und eine depressive Stimmung auswirken und daher den Krankheitsverlauf der Betroffenen mit CED verbessern können.

  16. Nutzen-Risiko-Evaluation: Zunehmende Bedeutung für Therapieentscheidungen bei Patienten mit Multipler Sklerose

    Directory of Open Access Journals (Sweden)

    Berger T

    2010-01-01

    Full Text Available Mit der Zulassung von 3 Interferon- β-Präparaten und Glatirameracetat hat Mitte der 1990er-Jahre eine völlig neue Ära in der Therapie der (schubförmigen Multiplen Sklerose (MS begonnen. Nach den ersten Jahren der Anwendung stellte sich die Erkenntnis ein, dass ein Therapiebeginn in der frühen Krankheitsphase, also zu einem Zeitpunkt, in dem die inflammatorische Krankheitsaktivität deutlicher präsent ist, effektiver in Bezug auf die Reduktion der Schubfrequenz und Verzögerung der Krankheitsprogression ist. Folglich wurden die genannten Therapien auch zur Behandlung nach dem Erstschub einer MS zugelassen. Den nächsten Meilenstein zur Therapie der schubförmigen MS setzte Natalizumab, einerseits, weil erstmals ein monoklonaler Antikörper zur MS-Behandlung zugelassen wurde, andererseits, weil Natalizumab praktisch doppelt so effektiv gegenüber den bisherigen Therapien ist. Die aktuellste Entwicklung für die MS-Therapie sind Medikamente mit entweder völlig neuen Wirkmechanismen und/oder oraler Applikation. Fingolimod und Cladribin sind jene, die bereits für eine Zulassung bei der EMA eingereicht sind. Die genannten Entwicklungen sprechen für eine erfolgreiche Translation „from bench to beside“, haben in den entsprechenden Phase-III-Studien eine zunehmende Effektivität in den frühen Krankheitsphasen demonstriert (und als Erfolgslatte etabliert und führ(ten im klinischen Alltag zu einer erheblichen Erweiterung des Therapiespektrums. Gleichzeitig wurde (vor allem im Lichte spezifischerer Wirkmechanismen und höherer Effektivität aber auch das Auftreten spezifischerer (und mitunter lebensbedrohlicher Nebenwirkungen und Risiken aufgezeigt. Die Verschreibung der bestmöglichen Therapie für individuelle Patienten, verbunden mit der „Qual der Wahl“ des „richtigen“ Medikaments zum „richtigen“ Zeitpunkt, erfordert eine zunehmende Auseinandersetzung und Abwägung von Nutzen und Risiko der vorhandenen (und zukünftigen Therapien bei MS. Davon handelt dieser Artikel.

  17. Energy-relevant cost and the deregulated market; Energierelevante Kosten - Bedeutung im liberalisierten Markt

    Energy Technology Data Exchange (ETDEWEB)

    Fuenfgeld, C.

    2001-07-01

    quantification of energy-relevant cost factors means economic assessment of technical processes in in-house energy management. Against the background of rising energy cost and more difficult energy acquisition, it can provide important decision aids. In-house implementation is based on the classic tool of cost calculation and takes into account both the production process and the energy and cost. [German] Die Quantifizierung der energierelevanten Kosten ist die oekonomisch richtige Bewertung der technischen Zusammenhaenge innerhalb der betrieblichen Energiewirtschaft und kann vor dem Hintergrund wieder ansteigender Energiepreise und dem durch die Marktentwicklung angestigenen Aufwand der betrieblichen Energiebeschaffung wichtige Entscheidungshilfen geben. Die betriebliche Umsetzung der Methode erfolgt mit den klassischen Werkzeugen der Kostenrechnung und verbindet den betrieblichen Produktionsfluss mit dem von Energie und Kosten. (orig.)

  18. 125 Jahre Berliner Afrika-Konferenz : Bedeutung für Geschichte und Gegenwart

    OpenAIRE

    Eckert, Andreas

    2009-01-01

    "Die Berliner Afrika-Konferenz vom 15. November 1884 bis zum 26. Februar 1885 im Reichstagspalais in der Wilhelmstraße jährt sich zum 125. Mal. Das öffentliche Echo ist gering; das offizielle Gedenken ist weitgehend ausgefallen. Das Auswärtige Amt sieht von Gedenkveranstaltungen ab. Kritiker wiederholen, dass eine kritische Aufarbeitung des Kolonialismus immer noch ausbleibe. In Afrika ist bis heute die Ansicht verbreitet, dass die Konferenz das 'freie Afrika' zerstört habe, künstliche Grenze...

  19. Thallium - ecological, environmental, medical and industrial significance. Thallium - oekologische, umweltmedizinische und industrielle Bedeutung

    Energy Technology Data Exchange (ETDEWEB)

    Zartner-Nyilas, G.; Valentin, H.; Schaller, K.H.; Schiele, R.

    1983-01-01

    A brief survey on the history, deposits, properties, extraction and industrial importance of thallium is followed by a discussion of its toxicological and biochemical actions and by an explanation of the part played by thallium in the world of work and in environment.

  20. SPECT in psychiatry; Die Bedeutung der Hirn-SPECT in der Psychiatrie

    Energy Technology Data Exchange (ETDEWEB)

    Kasper, S. [Universitaetsklinik fuer Psychiatrie, Wien (Austria); Gruenwald, F. [Bonn Univ. (Germany). Klinik fuer Nuklearmedizin; Danos, P. [Psychiatrische Universitaetsklinik, Bonn (Germany); Walter, H. [Universitaetsklinik fuer Psychiatrie, Wien (Austria); Klemm, E. [Bonn Univ. (Germany). Klinik fuer Nuklearmedizin; Bruecke, T. [Universitaetsklinik fuer Neurologie, Wien (Austria); Podreka, I. [Universitaetsklinik fuer Neurologie, Wien (Austria); Biersack, H.J. [Bonn Univ. (Germany). Klinik fuer Nuklearmedizin

    1994-10-01

    In the last fifteen years different attempts have been undertaken to understand the biological basis of major psychiatric disorders. One important tool to determine patterns of brain dysfunction is single emission computed tomography (SPECT). Whereas SPECT investigations are already a valuable diagnostic instrument for the diagnosis of dementia of the Alzheimer Type (DAT) there have not been consistent findings that can be referred to as specific for any other particular psychiatric diagnostic entity. Nevertheless, SPECT studies have been able to demonstrate evidence of brain dysfunction in patients with schizophrenia, depression, anxiety disorders, and substance abuse in which other methods showed no clear abnormality of brain function. Our manuscript reviews the data which are currently available in the literature and stresses the need for further studies, especially for prediction and monitoring psychiatric treatment modalities. (orig.) [Deutsch] In den vergangenen 15 Jahren wurde durch verschiedene methodologische Ansaetze versucht, die biologischen Ursachen psychiatrischer Erkrankungen naeher zu erforschen. Als eine bedeutende Methode hat sich dabei die Single-Photonen-Emissions-Computertomographie (SPECT) herausgestellt. Waehrend die SPECT-Untersuchungen bereits Eingang in die Routinediagnostik bei Demenzen vom Alzheimer-Typ gefunden haben, konnten fuer weitere psychiatrische Erkrankungen noch keine eindeutigen Befunde etabliert werden. Mit der SPECT-Methode ist es jedoch gelungen, funktionelle Veraenderungen des Gehirns von psychiatrischen Erkrankungen darzustellen, wie z.B. Schizophrenie, Depression, Angsterkrankungen bzw. Substanzmissbrauch. In Forschungsprotokollen wird durch die SPECT-Methode versucht, abzuklaeren, inwieweit es moeglich ist, innerhalb der Erkrankungsentitaeten psychiatrischer Erkrankungen oder auch diese uebergreifend eine Subklassifizierung zu finden und evtl. Gehirnsysteme ausfindig zu machen, die mit einer spezifischen Psychopathologie verbunden sind. In dem vorliegenden Manuskript wird die Datenlage zu den SPECT-Veraenderungen bei psychiatrischen Krankheiten zusammengestellt und betont, dass weitere Studien, insbesondere zur Praediktion und Verlaufsbeurteilung psychiatrischer Erkrankungen, notwendig sind. (orig.)

  1. The role of the power industry in national economy; Bedeutung der Energiewirtschaft fuer die Volkswirtschaft

    Energy Technology Data Exchange (ETDEWEB)

    Albrecht, Jutta; Gronwald, Marc; Karl, Hans-Dieter; Pfeiffer, Johannes; Roepke, Luise; Zimmer, Markus

    2011-07-01

    The study investigated the interdependence between energy supply and economic and industrial development. This is done, on the one hand, on the basis of the effects resulting from the current market structure and the activities of the power industry. On the other hand, the effects of the expected development of the energy sector are gone into, i.e. effects that reflect the adaptation to changing boundary conditions. This includes especially the challenges of climate protection measures, the political decision to enhance competition in the pipeline energy sector, and innovations to secure market positions.

  2. Identifikationsmerkmal Automobil bzw. Identifikation und Nutzen. Die theoretisch-emotionale Bedeutung des Autos

    Directory of Open Access Journals (Sweden)

    Pelters, Sarah

    2009-06-01

    Full Text Available The time when a car was used for the purpose of transportation only has probably never been. After its invention when such a machine was still hard to handle the thoughts about cars quickly moved from dangerous devils that should never be used to objects of freedom, safety and speed. They expressed wealth, status and independence and people started not only to want a car but soon enough also to differentiate between brands, models and styling. Now the question is not only how the car influenced modern life but also what the car - including its meaning and general understanding which it developed over the past - made of people. How much does a person identify with the own car, which is far more than just property?

  3. Die Beziehung zwischen Wissen, Bedeutung, Geist und Information: Der semognostische Ansatz

    Directory of Open Access Journals (Sweden)

    Algirdas Budrevičius

    2006-01-01

    Full Text Available Übersetzung des Aufsatzes "Interrelation of Knowledge, Meaning, Mind, and Information: The Semognostic Approach", erschienen in Informacijos Mokslai 2002, Vol. 21, p. 59-69 Knowledge, mind, and information are studied within a relatively new domain of science known as the cognitive science. Traditional cognitive science describes mind from the point of view of computation. This approach, however, is strongly criticized now. A different approach is considered in this paper. It is not a computational one within the traditional connotation of the term. Explanation starts by bringing forward the fact that the meaning of information is ignored in the traditional idea of computation. In this paper, meaning is taken as one of the two basic ideas to account for the mind. Knowledge is taken as the second elementary idea. Meaning and knowledge are considered as measurable quantitative values in space and time. Both elements are considered as being interrelated, being the two sides of one complex phenomenon of meaning-knowledge. Such approach to meaning, knowledge and intelligence is denoted by a neologism "semognostic" (from Greek "semantic" - "of meaning", and "gnostic" - "of knowledge". The field theory is considered to model semognostic phenomena. Further, it is claimed that various intellectual phenomena may be accounted for using the semognostic approach. The semognostic theory should be considered as a hypothesis that still needs to be proved. Some facts already known in various directions of science related to cognition may be employed for that purpose.

  4. Entwicklungsstufen der miozänen Cricetodontinae (Mammalia, Rodentia) Mittelspaniens und ihre stratigraphische Bedeutung

    NARCIS (Netherlands)

    Freudenthal, M.

    1963-01-01

    During the summer holidays of 1960 to 1963 a great many localities of Miocene and Pliocene mammals were discovered in the Southern part of Zaragoza province (Spain). Remains of both large and small mammals were found, the latter by sieving clays and marls. This small fauna consists mainly of Criceto

  5. Increasing flexibility of assets. Transition to flexible assets; Die steigende Bedeutung der Kraftwerksparkflexibilitaet

    Energy Technology Data Exchange (ETDEWEB)

    Aumueller, Adolf; Moik, Albert [EVN AG, Maria Enzersdorf (Austria); Rall, Hueseyin [STEAG GmbH, Herne (Germany)

    2016-07-01

    For the Energiewende flexibility is the key for the security of supply during the transition to an energy system based on renewables as well as for balancing the volatile generation in a renewable energy system. Storage is an integral module for delivering the flexibility needed by the future power system. Remaining R and D for storages and significant concession and building time for pump storage power plants lead to a time gap until storage is able to bear the brunt of delivering flexibility. The efficient and effective during the transition phase is the use of existing flexible power plants.

  6. Ist die Gesangskomplexita¨t der Amsel in einem intrasexuellen Kontext von Bedeutung?

    DEFF Research Database (Denmark)

    Hesler, Nana; Sacher, T.; Coppack, T.

    Vogelgesang wird fu¨r ein sexuell selektiertes Merkmal gehalten, das sowohl im inter- als auch im intrasexuellen Kontext eine Rolle spielt. Dabei nimmt man an, dass der Grad der Gesangskomplexita¨t ein ehrliches Signal fu¨r die Qualita¨t des Sa¨ngers darstellt. Bei Arten, die u¨ber ein gewisses...... Repertoire verschiedener Gesangsmuster verfu¨gen (z.B. verschiedener Strophentypen), stellt die Repertoiregro¨ße ein mo¨gliches Maß der Gesangskomplexita¨t dar. Die Amsel Turdus merula verfu¨gt u¨ber ein großes gesangliches Repertoire mit komplexem Aufbau ohne festgelegte Strophentypen. Dieses Repertoire...

  7. Zur Bedeutung der Lebensweltorientierung in der Jugendhilfe: Herausforderungen an Pädagogik und Psychologie

    OpenAIRE

    2003-01-01

    Eine Zäsur im Modernisierungsprozess der Jugendhilfe stellen die Strukturmaximen der Hilfen zur Erziehung auf der Rechtsgrundlage des KJHG dar. Zur zentralen Kategorie wird die Lebensweltorientierung. Mit ihr wurde der Suchtmittelkonsum von Jugendlichen zum Thema der öffentlichen Erziehung. In der Suchtprävention steht dabei die Förderung psychosozialer Gesundheit im Vordergrund. Suchtpräventive Konzepte bedürfen dazu einer entwicklungs- und gesundheitspsychologischen Fundierung. Die suchtprä...

  8. Neues in der Varizenchirurgie: Welche Bedeutung hat die Chirurgie in Zeiten von Laser, Schaum und Radiofrequenz

    Directory of Open Access Journals (Sweden)

    Assadian A

    2012-01-01

    Full Text Available Die Therapie der Stammvarikose der Vena saphena magna und parva hat in den vergangenen 10 Jahren einen Innovationsschub erlebt. Mehrere neue – mehrheitlich der Crossektomie und Stripping gegenüber als überlegen dargestellte – ausschließlich endoluminale Therapieoptionen haben den Markt erobert. Die Operation ist sicher nicht mehr für alle Patienten und alle Indikationen die optimale Therapie, die derzeitige Evidenz steht jedoch im krassen Gegensatz zur mehrheitlich aus merkantilen Absichten geführten Diskussion. Aus der derzeitigen Evidenzlage und Erfahrung sind sehr großlumige ( 10 mm, geschlängelte Stammvarizen mit ausgeprägten Seitenästen weiterhin chirurgisch besser versorgt. Auch ist ein BMI 27 als Risikofaktor für Rekanalisation nach endoluminalem Verfahren zu sehen.

  9. The Presence of Modifiable Residues in the Core Peptide Part of Precursor Nisin Is Not Crucial for Precursor Nisin Interactions with NisB- and NisC

    NARCIS (Netherlands)

    Khusainov, Rustem; Kuipers, Oscar P.

    2013-01-01

    Precursor nisin is a model posttranslationally modified precursor lantibiotic that can be structurally divided into a leader peptide sequence and a modifiable core peptide part. The nisin core peptide clearly plays an important role in the precursor nisin - nisin modification enzymes interactions, s

  10. Fourth National Incidende Study of Child Abuse and Neglect (NIS-4)

    Data.gov (United States)

    U.S. Department of Health & Human Services — NIS–4 data were collected to provide updated estimates of the incidence of child abuse and neglect in the United States and measure changes in incidence from the...

  11. Forecasting of outdoor thermal comfort index in urban open spaces: The Nis fortress case study

    Directory of Open Access Journals (Sweden)

    Bogdanović-Protić Ivana S.

    2016-01-01

    Full Text Available Outdoor thermal environment is affected by variables like air temperature, wind velocity, humidity, temperature of the radiant surfaces, and solar radiation, which can be expressed by a single number - the thermal index. Since these variables are subject to annual and diurnal variations, prediction of thermal comfort is of special importance for people to plan their outdoor activities. The purpose of this research was to develop and apply the extreme learning machine for forecasting physiological equivalent temperature values. The results of the extreme learning machine model were compared with genetic programming and artificial neural network. The reliability of the computational models was accessed based on simulation results and using several statistical indicators. According to obtained results, it can be concluded that extreme learning machine can be utilized effectively in short term forecasting of physiological equivalent temperature.

  12. PENGHAMBATAN PEMBENTUKAN HISTAMIN PADA DAGING IKAN TONGKOL (Euthynnus affi nis OLEH QUERCETIN SELAMA PENYIMPANAN

    Directory of Open Access Journals (Sweden)

    Nanda Radithia Prasetiawan

    2014-06-01

    Full Text Available Pengaruh penambahan quercetin terhadap kadar histamin daging ikan tongkol (Euthynnus affi nisselama penyimpanan pada suhu ruang dibahas melalui penelitian ini. Penambahan 0,5; 1,0; dan1,5% quercetin menyebabkan penurunan kadar histamin dan TPC daging ikan tongkol lumat padapenyimpanan jam ke-12, 24, dan 36. Kadar histamin mengalami penurunan yang signifi kan pada jamke-12 dari (74,613±0,513 mg/100 g menjadi (15,805±1,061 mg/100 g, (9,510±0,658 mg/100 g, dan(3,635±0,580 mg/100 g pada perlakuan penambahan 0,5; 1,0; dan 1,5% secara berurutan. Asam aminohistidin daging ikan tongkol dengan perlakuan penambahan quercetin mengalami penurunan yang lebihlambat selama penyimpanan dibandingkan perlakuan tanpa penambahan quercetin (kontrol.Kata kunci: histamin, histidin, ikan tongkol, quercetin, total plate countPENDAHULUANHistamin adalah senyawa amin biologisheterosiklik primer

  13. NIS occurrence - Non-native species impacts on threatened and endangered salmonids

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The objectives of this project: a) Identify the distribution of non-natives in the Columbia River Basin b) Highlight the impacts of non-natives on salmonids c)...

  14. Dynamics behaviour of an elastic non-ideal (NIS) portal frame, including fractional nonlinearities

    Science.gov (United States)

    Balthazar, J. M.; Brasil, R. M. L. F.; Felix, J. L. P.; Tusset, A. M.; Picirillo, V.; Iluik, I.; Rocha, R. T.; Nabarrete, A.; Oliveira, C.

    2016-05-01

    This paper overviews recent developments on some problems related to elastic structures, such as portal frames, taking into account the full interactions of the vibrating systems, with an energy source of limited power supply (small motors, electro-mechanical shakers). We include a discussion on fractional (rational) damping and stiffness effects on the adopted modelling. This was a plenary lecture, delivered in the event titled: Mechanics of Slender Structures, organized in Northampton, England from 21-22, September 2015.

  15. Pendrin and NIS antibodies are absent in healthy individuals and are rare in autoimmune thyroid disease

    DEFF Research Database (Denmark)

    Brix, Thomas H; Hegedüs, Laszlo; Weetman, Anthony P;

    2014-01-01

    prevalence than the controls: NISAb: 17% vs 0% (P Hashimoto's thyroiditis (HT) had NISAb, (P ...OBJECTIVE: Antibodies against thyroglobulin, thyroid peroxidase and the TSH receptor are accepted as pathophysiological and diagnostic biomarkers in autoimmune thyroid disease (AITD). In contrast, the prevalence, aetiology and clinical relevance of autoantibodies against the human sodium...

  16. EXPERIENCE WITH ROBOTIC LUMЕNIS CO LASER IN ENDOSCOPIC LARYNGEAL SURGERY

    Directory of Open Access Journals (Sweden)

    E. N. Novozhilova

    2014-01-01

    Full Text Available  2 The paper describes the first experience in using robotic CO laser at the Department of Head and Neck Tumors, Moscow City Cancer Hospital Sixty-Two. With advances in endoscopic techniques and anesthesiology, there have been new possibilities of usingdirect (rigid larygoscopy in conjunction with laser systems.The Lumеnis laser assembly consists of three interconnected components: a videocamera, an operating microscope, and directly CO laser. It includes a computer system that sets a program to perform an operation.The heart of the laser system is a scanning Digital Acu Blade micromanipulator. This unique assembly makes itpossible to control the area and depth of incision, to cut intricate shapes in relation to the surface anatomy, and to precisely control ablation and hemostasis. The effect of tissue carbonization during surgery is minimal at the expense of the physical characteristics and different modes of radiation. It is noted that this system allows organ-sparing treatment in cancer patients and their prompt rehabilitation after surgical interventions.

  17. Rahvuslik - kohustuslik publikupüünis / Anneli Aasmäe

    Index Scriptorium Estoniae

    Aasmäe, Anneli, 1973-

    2001-01-01

    Muusikalidest Eesti lavadel - 23. veebr. esietendub Pärnu Endlas "Hea lugu", 11. märtsil Vanemuises "Verevennad", 16. märtsil Tallinna Linnahallis "No, No, Nanette" ja 2. nov Tallinna Linnahallis "Hüljatud"

  18. Properties of Nisin Z and Distribution of Its Gene, nisZ, in Lactococcus lactis

    NARCIS (Netherlands)

    Vos, Willem M. de; Mulders, John W.M.; Siezen, Roland J.; Hugenholtz, Jeroen; Kuipers, Oscar P.

    1993-01-01

    Two natural variants of the lantibiotic nisin that are produced by Lactococcus lactis are known. They have a similar structure but differ in a single amino acid residue at position 27: histidine in nisin A and asparagine in nisin Z. The nisin variants were purified to apparent homogeneity, and their

  19. SERATTIA AS THE CAUSE OF AN INTRAHOSPITAL INFECTION AT THE NEUROCHIRURGICAL CLINIC IN NIS

    Directory of Open Access Journals (Sweden)

    Martin Novak

    2001-05-01

    Full Text Available Intrahospital infections represent a serious problem in medicine. Withneurochirurgical patients infections can seriously damage the quality of treatmentwhile in some cases they can threaten patients' lives. Meningitis, brain abscess,osteomyelitis or secondary wound healing are complications caused by infection. Inthe period between October, 28, to December, 24, 1999, at the Neurochirurgicalclinic in Niš there was an intrahospital infection caused by the bacteria Serattia. Thesource of the infection was not discovered. Comprehensive measures wereundertaken for disinfecting the operation block and the intensive treatment unit aswell as a sanitary examination of the staff. In 2000 there was no record of any newčaše of the infection caused by the bacteria.

  20. NisC Binds the FxLx Motif of the Nisin Leader Peptide

    NARCIS (Netherlands)

    Abts, Andre; Montalban-Lopez, Manuel; Kuipers, Oscar P.; Smits, Sander H.; Schmitt, Lutz

    2013-01-01

    Nisin is a model system for lantibiotics, a class of peptides displaying antimicrobial activity against various Gram-positive bacteria. After ribosomal synthesis, the precursor peptide is modified in two steps, of which the last one involves consecutive cyclization reactions mediated by the cyclase

  1. Shared Investment by NIS and National Labs Develops Cutting-Edge Safeguards Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Anheier, Norman C.; Williams, Laura S.

    2012-04-01

    This article, regarding a new technology for detecting undeclared enrichment at gas centrifuge enrichment plants, was written for the DOE/NNSA NA-24 Highlights, a newsletter intended for public release.

  2. Kinderarmut. Über ihre Bedeutung für Bildungsprozesse Heranwachsender und die Grenzen der Pädagogik

    OpenAIRE

    Liesner, Andrea; Wischmann, Anke

    2010-01-01

    Die Verfasserinnen setzen sich mit den Fragen auseinander, was Armut für die von ihr Betroffenen bedeutet, was die Pädagogik zur Verbesserung ihrer Situation beitragen kann und welche Herausforderung Armut für eine erziehungswissenschaftliche Forschung bedeutet, die sich für die heterogenen gesellschaftlichen Bedingungen von Bildung und Erziehung interessiert. Die empirische Basis der Untersuchung bildet Kinderarmut in Hamburg, in einer der reichsten Großstädte Deutschlands. Die Verfasserinne...

  3. Krebstiere (Crustacea) – Biologie, Vorkommen, Haltung und Erkrankungen, sowie ihre Bedeutung als Zootierobjekte und Lebensmittelressourcen : eine Literaturstudie

    OpenAIRE

    Walther, Marc

    2008-01-01

    Crustaceen stellen nicht nur eine biologisch interessante Tiergruppe dar, sondern erlangen aufgrund ihrer Haltung in Zoos und durch ihre Nutzung als wichtige Lebensmittelquelle ein immer größer werdendes Interesse. Gerade in den letzen Jahren gab es eine enorme Informationsflut über Erkrankungen bei Crustaceen. Dies wurde als Anlass genommen, das heutige Wissen in einer Abhandlung zusammenzufassen. Die Literaturstudie wird durch eine systematische zoologische und lebensmitterel...

  4. The macro economic relevance of renewable energy sources for Switzerland; Volkswirtschaftliche Bedeutung erneuerbarer Energien fuer die Schweiz

    Energy Technology Data Exchange (ETDEWEB)

    Nathani, C.; Schmid, C.; Rieser, A.; Ruetter, H. [Ruetter und Partner, Rueschlikon (Switzerland); Bernath, K.; Felten, N. von [Ernst Basler und Partner, Zollikon (Switzerland); Walz, R.; Marscheider-Weidemann, F. [Fraunhofer Institut fuer System- und Innovationsforschung, Karlsruhe (Germany)

    2013-01-15

    This study analyses the economic relevance of renewable energy in Switzerland. In 2010 the enterprises in the renewable energy sector generated a gross value added of 4.8 bn CHF (equalling 0.9% of Swiss GDP). Employment in this sector approximated 22,800 fulltime jobs (0.6% of total Swiss employment). Including supply chain companies, 1.5% of Swiss GDP and 1.2% of total employment can be related to the use of renewable energy. Exports of renewable energy related goods and services equalled 3.2 bn CHF. Since 2000 the Swiss renewable energy sector has experienced an above-average annual growth of more than 4%. Its potential development until the year 2020 was studied with two scenarios. In the policy scenario, that assumes additional policy measures for renewable energy promotion, direct value added of the renewable energy sector would amount to 6.4 bn CHF (+33%), direct employment would increase to 29,200 fulltime jobs (+28%, gross effects resp.). In the more conservative baseline scenario, growth would be much weaker, but still slightly stronger than anticipated for the average economy. (authors)

  5. Regionalökonomische Bedeutung kleiner Wallfahrtsorte - Lokale Wertschöpfung am Beispiel Biberbach (Bayerisch-Schwaben)

    Science.gov (United States)

    Hilpert, Markus; Mahne-Bieder, Johannes; Stifter, Vanessa

    2016-09-01

    Today pilgrimage is experiencing an increasing interest, although motives are notable changing. Sites along pilgrim routes normally profit in an economically way. But until today regional economic effects of even very small pilgrimage sites are underexplored. Therefore economic impulses of the pilgrimage site in Biberbach (Bavaria) were identified using interviews and calculations. According to that the 10,000 visitors per year generate nearly 30,000 € gross turnover and 0.5 jobs. So even small pilgrimage sites can obviously produce a notable increase of local EVA.

  6. Man and room climate. The importance of thermal comfort; Der Mensch und das Raumklima. Zur Bedeutung der thermischen Behaglichkeit

    Energy Technology Data Exchange (ETDEWEB)

    Hoefte, Klaus [Uponor Academy, Ochtrup (Germany)

    2009-07-01

    Room climate has become increasingly important during the past few decades as humans spend about 90 percent of their time inside rooms. Influencing factors are acoustics, lighting, air quality and thermal room climate. The contribution focuses on thermal room climate and room air quality which are the most important of these factors. (orig.)

  7. Fausts Wette und der Prozess der Moderne. Zur historischen und aktuellen Bedeutung der Tragödie Goethes

    Directory of Open Access Journals (Sweden)

    Michael Jaeger

    2006-12-01

    Full Text Available O artigo enfatiza que um elemento central no pacto demoníaco configurado por Goethe em seu Fausto simboliza também a força motriz da Modernidade: a negação ininterrupta do presente. Diferentemente das interpretações tradicionais que vêem Fausto como figura positiva e a sua aspiração como virtude do homem moderno, o autor expõe a dimensão destrutiva da inquietude fáustica, a qual deve ser questionada pelo público contemporâneo. Na perspectiva do autor, os contrapontos efetivos ao ritmo destrutivo da Modernidade seriam, como o próprio Goethe parece sugerir no drama, a atitude religiosa (em sentido amplo, não convencional e a arte de inspiração clássica, que propicia a reflexão e o “deter-se” no instante presente.

  8. The strategic role of district heating in renewable energy use; Die strategische Bedeutung der Nahwaerme zur Nutzung erneuerbarer Energien

    Energy Technology Data Exchange (ETDEWEB)

    Nast, M. [Deutsches Zentrum fuer Luft- und Raumfahrt e.V. (DLR), Stuttgart (Germany). Abt. Systemanalyse und Technikbewertung; Boehnisch, H. [Zentrum fuer Sonnenenergie- und Wasserstoff-Forschung Baden-Wuerttemberg (ZSW), Stuttgart (Germany)

    1998-02-01

    District heating allows the utilization of biomass in low emission heating plants, the exploitation of solar energy and the seasonal storage of heat. If a sustainable energy supply system is to be created, district heating must not only be the system of choice for new housing districts but must also be retrofitted in existing settlements. The detailed analysis of a rural community shows that large segments of existing buildings can be connected to district heating systems even in regions with predominantly single dwellings and rural housing densities. The conditions necessary for establishing district heating systems are discussed. (orig.) [Deutsch] Nahwaermesysteme ermoeglichen, fossile und biogene Brennstoffe einzusetzen und lassen sich an saisonale Waermespeicher anschliessen. Zum Aufbau einer nachhaltigen Energieversorgung ist Nahwaerme nicht nur in Neubaugebieten notwendig sondern muss auch in den schon laenger genutzten Gebaeudebestand integriert werden. Das Beispiel einer umfassend analysierten Landgemeinde zeigt, dass ein grosser Teil des bestehenden Gebaeudebestandes an Waermenetze angeschlossen werden kann, selbst bei vorherrschender Bebauung mit Einfamilienhaeusern und laendlichen Gebaeudedichten. Die notwendigen Rahmenbedingungen fuer den Aufbau einer Nahwaermeversorgung werden erlaeutert. (orig.)

  9. The importance of risk models for management of pulmonary nodules; Die Bedeutung von Risikomodellen fuer das Management pulmonaler Rundherde

    Energy Technology Data Exchange (ETDEWEB)

    Prosch, H.; Baltzer, P. [Medizinische Universitaet Wien, Allgemeines Krankenhaus, Universitaetsklinik fuer Radiologie und Nuklearmedizin, Wien (Austria)

    2014-05-15

    Pulmonary nodules are a frequent finding in computed tomography (CT) investigations. Further diagnostic work-up of detected nodules mainly depends on the so-called pre-test probability, i.e. the probability that the nodule is malignant or benign. The pre-test probability can be calculated by combining all relevant information, such as the age and the sex of the patient, the smoking history, and history of previous malignancies, as well as the size and CT morphology of the nodule. If additional investigations are performed to further investigate the nodules, all results must be interpreted taking into account the pre-test probability and the test performance of the investigation in order to estimate the post-test probability. In cases with a low pre-test probability, a negative result from an exact test can exclude malignancies but a positive test cannot prove malignancy in such a setting. In cases with a high pre-test probability, a positive test result can be considered as proof of malignancy but a negative test result does not exclude malignancy. (orig.) [German] Pulmonale Rundherde sind ein haeufiger Befund bei CT-Untersuchungen des Thorax. Die weiterfuehrende Abklaerung der gefunden Rundherde haengt im Wesentlichen von der so genannten Vortestwahrscheinlichkeit ab, der Wahrscheinlichkeit ob der Rundherd maligne ist oder nicht. Diese Vortestwahrscheinlichkeit laesst sich durch die Kombination aller relevanten Vorinformationen wie Alter und Geschlecht des Patienten, Raucheranamnese, Tumoranamnese, Groesse und CT-Morphologie des Rundherdes genau berechnen oder intuitiv abschaetzen. Werden weiterfuehrende Untersuchungen zur Abklaerung des Rundherdes durchgefuehrt, ist das Ergebnis dieser Untersuchung, die Nachtestwahrscheinlichkeit fuer das Vorliegen von Malignitaet, in Abhaengigkeit von der Vortestwahrscheinlichkeit und der Testguete der Untersuchung zu interpretieren. Waehrend ein genauer Test im Falle niedriger Vortestwahrscheinlichkeiten Malignitaet mit Sicherheit ausschliessen kann, ist ein positives Testergebnis in einem solchen Setting niemals als 100 %ig sicher einzustufen. Umgekehrt verhaelt es sich im Falle sehr hoher Vortestwahrscheinlichkeiten: hier kann eine positive Diagnose als sicher angenommen, der Ausschluss der Erkrankung jedoch nur als unsicher eingestuft werden. (orig.)

  10. Verletzungsschwere und -lokalisationen polytraumatisierter Kinder im Vergleich zu Erwachsenen und deren Bedeutung für das Schockraummanagement

    DEFF Research Database (Denmark)

    Zwingmann, J; Schmal, H; Südkamp, N P

    2008-01-01

    PURPOSE: The treatment of paediatric polytrauma patients in the emergency room is not common. The knowledge of specific injuries in consideration of the age-specific characteristics is of particular importance for precise diagnostics and therapy. The goal of this study is the aquisition of the fr...

  11. Zur Bedeutung der linksventrikulären Hypertrophie bei arterieller Hypertonie im Praxisalltag - Focus auf das LIL-Projekt

    Directory of Open Access Journals (Sweden)

    Eber B

    2008-01-01

    Full Text Available Bei Hypertrophie des Herzens im Rahmen einer essentiellen Hypertonie, häufiger vorkommend bei sekundären Hypertonieformen, nimmt das Risiko für Morbidität und Mortalität signifikant zu. Dies sollte in der Praxis wesentlich mehr Beachtung finden. Eine Regression der linksventrikulären Hypertrophie kann durch alle antihypertensiven Maßnahmen erzielt werden, dadurch wird die Prognose der Hypertoniker verbessert. Die Wahl des richtigen Antihypertensivums und eine eher höhere Dosierung sind weitere entscheidende Kriterien für ein besseres Outcome. Losartan erfüllt diese Anforderungen auch aus ökonomischer Sicht, vor allem in der Tagesdosierung von 100 mg in Kombination mit Hydrochlorothiazid (HCTZ, wie EBM-Trials nachweisen konnten (z. B. LIFE-Studie. In dem österreichweiten LIIFE-IN-LIFE- (LIL- Projekt konnten diese Erkenntnisse erstmals in die Praxis umgesetzt werden, wie erste Analysen ergaben.

  12. Autoimmunität der Schilldrüse und Bedeutung bei Kinderwunsch und in der Schwangerschaft

    Directory of Open Access Journals (Sweden)

    Quadbeck B

    2009-01-01

    Full Text Available Autoimmunthyreopathien können bei Schilddrüsenstoffwechselstörungen (v. a. Hypothyreose Zyklusstörungen (v. a. Oligomenorrhö verursachen und sich somit auf die Fertilität der Frau negativ auswirken. Häufigste Ursache einer erworbenen Hypothyreose bei Frauen im gebärfähigen Alter ist eine atrophisch verlaufende Autoimmunthyreoiditis mit einer Prävalenz von 0,5 % für manifeste und 5 % für milde Hypothyreosen. Risikopatientinnen sollten daher, da der Bedarf an Schilddrüsenhormon in der Schwangerschaft bis zu 50 % steigen kann, erkannt und frühzeitig mit Schilddrüsenhormon behandelt werden. Eine Schilddrüsenüberfunktion wird im gebärfähigen Alter der Frau in bis zu 85 % der Fälle durch eine immunogene Hyperthyreose vom Typ Morbus Basedow verursacht. Die milden Verlaufsformen sind zumeist nicht mit Zyklusstörungen assoziiert. Eine Therapie mit niedrig dosierten antithyreoidalen Medikamenten ist auf alle Fälle erforderlich, ggf. sollte vor einer Schwangerschaft bei bekannter hoher immunologischer Aktivität über eine frühzeitige definitive Therapie (Operation, Radiojodtherapie nachgedacht werden. Eine im ersten Jahr nach der Geburt auftretende Postpartum-Thyreoiditis kommt bei 2–20 % der Schwangeren vor. Bei ca. 10 % der Schwangeren sind bereits in der Frühschwangerschaft TPO-Antikörper messbar. Von diesen entwickelt jede 2. Schwangere eine Postpartum-Thyreoiditis. Diese kann einen unterschiedlichen Verlauf nehmen (monophasisch – zumeist Entwicklung einer Hypothyreose, vollkommen ausheilen oder nach anfänglich hyperthyreoter Phase in eine manifeste Hypothyreose münden (biphasischer Verlauf. Frühschwangerschaft und die Postpartalzeit gelten bei allen Autoimmunthyreopathien als immunologisch empfindliche Phasen, in denen Risikopatientinnen kontrolliert werden sollten.

  13. Was ist das Hidden Web? Die Entstehung, Eigenschaften und gesellschaftliche Bedeutung von anonymer Kommunikation im Hidden Web.

    OpenAIRE

    Papsdorf, Christian

    2016-01-01

    More than two-and-a-half million people currently use the Tor network to communicate anonymously via the Internet and gain access to online media that are not accessible using standard Internet technology. This sphere of communication can be described as the hidden web. In part because this phenomenon is very recent, the subject has scarcely been studied in the social sciences. It is therefore the purpose of this paper to answer four fundamental questions: What is the hidden web? What charact...

  14. Neutralisierende Antikörper gegen Interferon-beta in der Therapie der Multiplen Sklerose: Haben sie eine klinische Bedeutung?

    Directory of Open Access Journals (Sweden)

    Gneiß C

    2003-01-01

    Full Text Available Rekombinantes Interferon-beta (IFN-beta gilt als Therapie der ersten Wahl bei schubförmig verlaufender Multipler Sklerose (MS. Bis zu einem Drittel der Patienten entwickelt im Therapieverlauf neutralisierende Antikörper (NAB gegen IFN-beta. NAB, welche eine Untergruppe aller Antikörper gegen IFN-beta darstellen, reduzieren die biologische Aktivität und in der Folge die Wirksamkeit von IFN-beta, indem sie die Bindung von IFN-beta am Rezeptor blockieren. Zahlreiche Studien belegen, daß die Anwesenheit von NAB zu einem Anstieg der Schubfrequenz und zu einer Zunahme der Läsionslast im Zentralnervensystem führt. Während NAB meist zwischen 6 und 18 Monaten nach Therapiebeginn mit IFN-beta nachweisbar sind, zeigt sich die negative Auswirkung auf den klinischen Effekt erst ab dem zweiten bis dritten Behandlungsjahr. NAB unterliegen einem dynamischen Prozeß; Studien zeigen, daß NAB-positive Patienten im Therapielangzeitverlauf trotz Fortführung der IFN-beta-Therapie wieder in den NAB-negativen Status zurückkehren. Um das Problem der NAB gegen IFN-beta bewältigen zu können, ist ein NAB-Screening ab Therapiebeginn in regelmäßigen Abständen zu empfehlen. So können NAB-positive MS-Patienten zu einem Zeitpunkt erfaßt werden, zu dem der Antikörpertiter noch niedrig ist, und Strategien in Erwägung gezogen werden, welche zur Rückbildung der NAB führen.

  15. Significance of international hydropower storages for the German energy turnaround; Bedeutung der internationalen Wasserkraftspeicherung fuer die deutsche Energiewende

    Energy Technology Data Exchange (ETDEWEB)

    Hobohm, Jens; Ess, Florian [Prognos AG, Berlin (Germany)

    2013-01-15

    Prediction is very difficult, especially if it's about the future. This witticism, which has been alternatively ascribed to Mark Twain, Karl Valentin, Niels Bohr and Winston Churchill, could hardly be truer than when applied to the wind and sun, especially in the case of long-term forecasts. Wind power and photovoltaic plant capacities are what needs to grow most if renewable energies really are to cover 80% of Germany's energy supply by the year 2050. Other renewable energy resources do not have the potential to contribute substantially to achieving the goals proclaimed by the German federal government. Some 64% of electricity production and 70% of installed power capacity will be coming from the wind and sun in the year 2050, according to recent calculations. A study prepared by Prognos AG on behalf of the German National Committee of the World Energy Council has investigated the question as to what extent international hydropower storages are capable of taking up surplus electricity and holding it available as a power reserve.

  16. The value of MRI in the diagnosis of cerebral infection. Die Bedeutung der Kernspintomographie in der Diagnostik zerebraler Infektionen

    Energy Technology Data Exchange (ETDEWEB)

    Glathe, S.; Heindel, W.; Steinbrich, W. (Koeln Univ. (Germany, F.R.). Inst. fuer Radiologische Diagnostik)

    1989-09-01

    Amongst 1.345 MR examinations of the skull 49 patients were suspected of a cerebral infection. With a knowledge of the clinical situation, the abnormal findings were classified according to their localization, number, extent and distribution. The final diagnoses included meningitis, meningo-encephalitis, and abscesses of varying etiology. CT was carried out in 29 patients; it was found that MRI was more sensitive and able to show the lesion at an earlier stage (sensitivity 90% compared with 66%). Observations of proton density and relaxation time combined with morphological criteria and clinical history reduced differential diagnoses. On the other hand, the changes due to intracranial infections lead to an inflammatory reaction that may be similar to the findings in degenerative or even tumorous cerebral lesions. This explains why twelve patients with abnormal MRI findings were erroneously diagnosed as having cerebral infections. (orig.).

  17. Significance and occurrence of gas hydrates in offshore areas; Bedeutung und Vorkommen von Gashydraten im Offshore-Bereich

    Energy Technology Data Exchange (ETDEWEB)

    Wehner, H.; Faber, E. [Bundesanstalt fuer Geowissenschaften und Rohstoffe, Hannover (Germany)

    1997-12-31

    The present contribution describes the boundary and stability conditions under which gas hydrates are able to exist. It also discusses the occurrence and genesis of gas hydrates and their role as an energy raw material of the future. Furthermore, it deals with the possibility of gas hydrates being the cause of submarine slumps and with their influence on the climate. (MSK) [Deutsch] Die Rand-und Stabilitaetsbedingungen unter denen die Gashydrate existent sein koennen werden beschrieben. Ebenso wird das Vorkommen von Gashydraten, ihre Genese und ihre Rolle als Energierohstoff der Zukunft diskutiert. Darueberhinaus werden die Gashydrate als moegliche Ursache fuer untermeerische Rutschungen und ihr Einfluss auf Klimaaenderungen erlaeutert.

  18. Pulmonary embolism. Clinical relevance, requirements for diagnostic and therapeutic strategies; Lungenembolie. Klinische Bedeutung, Anforderung an die Diagnostik und Behandlungsoptionen

    Energy Technology Data Exchange (ETDEWEB)

    Nowak, F.G.; Halbfass, P.; Hoffmann, E. [Herzzentrum Muenchen-Bogenhausen, Staedtisches Klinikum Muenchen GmbH, Klinik fuer Kardiologie und Internistische Intensivmedizin, Muenchen (Germany)

    2007-08-15

    In the population the annual incidence of pulmonary embolism amounts to 1.3-2.8 per 1000 at the age of 65-89 years. Mortality reaches about 17% within the first 3 months. Acute pulmonary embolism is characterized by an increase in pulmonary arterial pressure and an impairment of the pulmonary gas exchange. Elevation of the right cardiac pressure up to right heart decompensation may follow. In addition, hypoxemia, hyperventilation, dead space ventilation, right to left shunting, bronchoconstriction, and vasoconstriction may occur. Clinical examination, ECG, laboratory findings such as elevated D-dimer, blood gas analysis, ultrasound examination of the veins of the lower extremities, and transthoracic echocardiography are acutely available diagnostic methods of an emergency department. In addition, extensive diagnostic procedures like pulmonary scintigraphy and pulmonary angiography may be required. The aim is to get a definite diagnosis as quickly as possible to direct therapy. In acute pulmonary embolism with cardiac shock, monitoring and stabilization of the circulatory function as well as an appropriate anticoagulant therapy are essential. In some cases surgery or a local fibrinolytic intervention is indicated. (orig.) [German] Die Lungenembolie stellt eine potenziell lebensbedrohliche akute Erkrankung dar, deren Prognose durch die fruehzeitige Diagnostik und effektive gerinnungshemmende Therapie bestimmt wird. Die jaehrliche Inzidenz der Lungenembolie liegt zwischen 1,3-2,8/1000 Einwohner im Alter zwischen 65 und 89 Jahren. Die Mortalitaet einer akuten Lungenembolie erreicht etwa 17% innerhalb der ersten 3 Monate. Die akute Lungenembolie ist durch Erhoehung des pulmonalarteriellen Drucks mit Stoerung des Gasaustauschs und Anstieg des Drucks im rechten Herzen bis hin zur Rechtsherzdekompensation gekennzeichnet. Weitere Folgen sind Hypoxaemie, Hyperventilation, Totraumventilation, Rechts-links-Shunt und Broncho- sowie auch Vasokonstriktion. Anamnese und klinische Untersuchung sowie EKG-Diagnostik, Roentgen-Thorax, Laborbestimmung des D-Dimer und Blutgasanalyse sind Bestandteile der Basisdiagnostik und lassen die Diagnose Lungenembolie mit Wahrscheinlichkeit zu. Die transthorakale Echokardiographie erlaubt die prognostisch bedeutsame Beurteilung der rechtsventrikulaeren Belastung, und die Ultraschalluntersuchung der Beine kann die haeufigste Lokalisation des Ursprungs der Thrombembolie nachweisen. Wichtigstes bildgebendes Verfahren zum Nachweis der Lungenembolie ist das Spiral-CT. Aufwaendigere Untersuchungen - wie Perfusions- und Ventilationsszintigraphie bis hin zur invasiven Pulmonalisangiographie - koennen sich anschliessen. Bei massiver Lungenembolie mit kardiogenem Schock stehen intensivmedizinisches Monitoring und kreislaufunterstuetzende Therapie ebenso im Vordergrund wie der Einsatz einer rekanalisierenden Therapie, in der Regel Thrombolyse. In besonders schweren Faellen kann auch ein chirurgisches oder kathetergestuetztes Vorgehen indiziert sein. Der Akuttherapie folgt die Antikoagulation zur Rezidivprophylaxe. (orig.)

  19. Neue Freunde durch neue Medien? Die Bedeutung computervermittelter Kommunikation für männliche Jugendliche

    Directory of Open Access Journals (Sweden)

    Ingo Straub

    2005-10-01

    Full Text Available Betrachtet man einschlägige Untersuchungen zum Mediennutzungsverhalten, zeigt sich, dass in der Regel von männlichen und weiblichen Mediennutzungspraxen gesprochen und damit implizit davon ausgegangen wird, dass es sich bei Männern und Frauen, Jungen und Mädchen um monolithische Blöcke handelt, die in sich weitgehend homogen bestimmte Medien nutzen oder nicht nutzen. Die Gegenüberstellung der beiden Genus-Gruppen ist oftmals mit stereotypen Dichotomisierungen verbunden, die sich beispielsweise in Schlussfolgerungen niederschlagen, dass vor allem Mädchen zu kommunikativen Tätigkeiten wie Chatten und E-Mailen tendieren, während Jungen verstärkt Interesse an Spielen, Programmieren und am Download von Dateien zeigen. Anhand empirischer Analysen soll verdeutlicht werden, dass innerhalb der Gruppe der männlichen Jugendlichen, die sich in jugendkulturellen Szenen bewegen, Differenzierungen feststellbar sind, die in landläufigen Untersuchungen unberücksichtigt bleiben. Der Beitrag konzentriert sich dabei auf diejenigen Textpassagen innerhalb der Gruppendiskussionen, in denen das Thema computervermittelte Kommunikation von den Jugendlichen (meist auf alltagsweltliche Art und Weise behandelt wird.

  20. Bedeutung kleinräumiger Daten für die Evaluation von Bildungsprojekten. Das Beispiel der Junior Uni Wuppertal

    Science.gov (United States)

    Makles, Anna

    2016-12-01

    The Junior University, a University for children and youth in the city of Wuppertal, offers science courses that target children and youth from all socioeconomic backgrounds. The first evaluation study done by the University of Wuppertal in 2013 aimed at examining whether the Junior University has achieved this goal. The main challenge of our analysis was to approximate missing individual information on socioeconomic status by using spatial data. Therefore, we georeferenced address information of the Junior University students and linked those results to different characteristics available for about 2800 city blocks in the city of Wuppertal. We found out that indeed the Junior University succeeds in attracting children and youth from all socioeconomic backgrounds. The results show that many of the students live in poor neighborhoods or in neighborhoods with a high share of immigrants.

  1. Inkarniertes Bewusstsein. Die Bedeutung der Leiblichkeit bei Emmanuel Levinas als Herausforderung für die Theologie

    Directory of Open Access Journals (Sweden)

    Erwin Dirscherl

    2017-01-01

    Full Text Available The article is focused on the question of carnality in the thinking of Emmanuel Levinas and its contribution to theological anthropology. At first, it deals with Levinas’ critique of western philosophy concerning the fact that it neglects carnality as a constitutive dimension of human identity. The identity of a subject is not founded on its thinking outside time and space but on its concrete carnal existence as an “incarnated consciousness”. The next accent of the article is put on the importance of carnal proximity with regard to another man as related to the responsibility for the neighbour. Body becomes a place of human presence and simultaneously a place of transcendence. The conclusion is based on Rahner’s idea about body as a place where God’s Word is present.

  2. Diagnostische Bedeutung von pentavalenter 99m Tc-Dimercaptobern-steinsaure ([V]-DMSA) bei Kopf-Hals-Tumoren

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The purpose of this investigation was to assess the biodistribution of 99m Tc-[V]-DMSA in human being,and its diagnostic value in patients with head and neck tumours.20 patients with histologically confirmed head and neck tumours were examined with planar as well as SPECT scintigraphy. Whole body scintigraphy in different time after injection of 99m Tc-[V]-DM-SA was performed to assess the major sequential organ biodistribution. Our results showed that the blood clearance of 99m Tc-[V]-DMSA was bi-exponential. All organs except kidneys showed a relatively rapid elimination of 99m Tc-[V]-DMSA. The kidneys showed a increasing accumulation in the first 2h, which is probably due to the tubular mabsorption of 99m Tc-[V]-DMSA. In 15 of 20 patients, 19 lesions could be proven by means of planar scintigraphy (corresponding sensitivity of 75%). 29 lesions in 18 patients could however be detected by the application of SPECT (corresponding sensitivity of 90%). Except primary tumours and local lymphadenmetastases in 5 patients distant metastases (3 thorax wall,I liver and I ingvinal/paravesicle) were found. Altogether a sensitivity of 76.9% and a specificity of 71.4% were calculated for the detection of primary tumour. The sensitivity and specificity for the exploration of lymphadenmetastases were 75% and 100%. In conclusion, this study shows that 99m Tc-[V]-DMSA, particularly with SPECT imaging, is useful in localising the primary tumours and lymphadenmetastases as well as distant metastases of head and neck tumours. The possible therapeutic application of 188/186Re-[V]-DMSA is also evaluated.

  3. Characterization and staging of renal tumors: significance of MRI diagnostics; Charakterisierung und Staging von Nierentumoren: Bedeutung der MRT-Diagnostik

    Energy Technology Data Exchange (ETDEWEB)

    Kalinka, A.; Gerlach, A.; Arlart, I.P.; Guenes, N.; Hauser, T.K.; Wuerstlin, S. [Inst. fuer Diagnostische und Interventionelle Radiologie, Katharinenhospital Stuttgart (Germany); Bosse, A. [Inst. fuer Pathologie, Katharinenhospital Stuttgart (Germany)

    2006-03-15

    Purpose: Retrospective evaluation of MRI in the diagnosis of renal masses and determination of the correlation of MRI with histology or follow-up. Materials and methods: 46 consecutive patients (13 female, 33 male, mean age 64.7 yrs) with suspected renal tumors were examined with a 1.5T MR scanner using a standardized protocol (TSE T2fs, 2DGRE T1, dynam. ce3DGRE T1fs, ce2DGRE T1fs, ce3DGRE urogram). Results: 142 renal lesions were found with diameters of <2 cm up to 14 x 18 cm. A primary classification as solid and cystic lesions was performed according to MRI criteria. In 29 cases we found lesions bilaterally, in 17 patients only in one kidney, and in four cases we found multifocal renal tumors unilaterally (n=3) or bilaterally (n=1). In 22 patients with renal tumors, cystic lesions could be seen as well. In 19 cases these were uncomplicated cysts, and in 3 cases these were complicated cysts. 35/43 lesions were histologically proven solid vascularized tumors (29 renal cell carcinomas, 6 urothelial carcinomas), five additional masses with tumor signs in MRI appeared to be progressive during follow-up thus suggesting malignancy, and one case was a multifocal bilateral renal tumor. 3/43 lesions were initially reported as being suspected of malignancy but were proven during follow-up or histologically to be benign. Tumor thrombus was depicted in MRI in the renal vein in 5 cases, stretching into the IVC in 4 cases and proven histologically in 4 and 3 cases, respectively. Of these solid masses, 99 cystic lesions could be differentiated clearly in MRI (88 simple cysts, 11 complicated cysts) that remained unchanged during follow-up (6-65 months) or were proven to be cysts histologically. In 17 cases these cysts were bilateral, in 19 cases unilateral, and 33 kidneys showed multicystic changes. In characterizing renal masses, MRI showed a positive predictive value of 93% for the diagnosis of a malignant tumor. The T-stage of histologically proven renal cell carcinomas using MRI was correct in 89%. (orig.)

  4. Die Bedeutung von Infinitiv und Konjunktiv als Modi der Nicht-Mitteilung (unter besonderer Berücksichtigung des Italienischen

    Directory of Open Access Journals (Sweden)

    Pichler, Claudia

    Full Text Available The infinitive (also referred to as "Nennform" is positioned both formally and functionally between noun and verb. This so-called "intermediate status" and the pragmatic-communicative characteristics/functions resulting from it are described on the basis of a selection of Old Italian language samples. The study therefore examines the correlation between morphosyntactic and informational structure and focuses in particular on the morphosyntactic codification of thematic elements of expression. An accordance can be ascertained regarding the pragmatic-communicative characteristics/functions of the infinitive ( i.e. infinitive constructions of the type: definite article + infinitive + subject and the (thematic subjunctive.

  5. Wanderung der Barbaren? Zur Entstehung und Bedeutung des Epochenbegriffs ‚Völkerwanderung‘ bis ins 19. Jahrhundert

    OpenAIRE

    Steinacher, Roland

    2017-01-01

    Die Spätantike und das frühe Mittelalter hatten keine Vorstellung von einem ‚Wandern der Völker‘, und auch die Epochengrenzen zwischen Altertum und Mittelalter sind eine gelehrte Konstruktion der Frühen Neuzeit. Seit dem frühen 16. Jahrhundert entstanden sowohl das zugrunde liegende Geschichtsbild als auch die Begriffe migratio gentium und später ‚Völkerwanderung‘. Der frühneuzeitliche Völkerwanderungsbegriff hatte wiederum vielerlei Bezüge zur antiken Literatur und deren Vorstellung von W...

  6. Die funktionelle Bedeutung von Projektionszellen des medialen entorhinalen Cortex in der Interaktion zwischen entorhinalem Cortex und Hippocampus

    OpenAIRE

    Gloveli, Tengis

    2000-01-01

    Der entorhinale Cortex (EC) nimmt eine zentrale Stellung im limbischem System ein und ist darüber hinaus eine Verbindungsstelle zwischen Hippocampus und Cortex. Um die Eigenschaften der Projektionszellen im EC genauer zu charakterisieren, führten wir intrazelluläre Ableitungen an den Neuronen der oberflächlichen (Schicht II und III) und der tiefen (Schicht IV-VI) Schichten durch, von denen etwa ein Viertel während der Ableitung mit dem Farbstoff Biozytin gefärbt werden konnten. In Schicht III...

  7. Long-term ambient air pollution exposure and risk of high blood pressure among citizens in Nis, Serbia.

    Science.gov (United States)

    Stanković, Aleksandra; Nikolić, Maja

    2016-01-01

    Epidemiological studies suggest that long-term exposure to air pollution increases the risk for high blood pressure (BP). The aim of our study is to evaluate any effects in BP in citizens exposed to long-term ambient air pollution. The subjects are 1136 citizens, aged 18-70 years, living for more than 5 years in the same home in the areas with a different level of air pollution. The air concentrations of black smoke and sulfur dioxide were determined in the period from 2001 to 2011. We measured systolic and diastolic BP and heart rate. Multivariate methods were used in the analysis. Alcohol consumption had the greatest influence on the incidence of hypertension as a risk factor (RR: 3.461; 95% CI: 1.72-6.93) and age had the least (RR: 1.23; 95% CI: 1.183-1.92). Exposure to air pollution increases risk for developing hypertension 2.5 times (95% CI: 1.46-4.49). Physical activity has proved to be statistically significant protective factor for the development of hypertension. Long-term exposure to low levels of main air pollutants is significantly associated with elevated risk of hypertension.

  8. UM OUTRO OLHAR SOBRE A EFICIÊNCIA DOS MERCADOS: O CASO DAS BOLSAS DE APOSTAS DE TÊNIS

    Directory of Open Access Journals (Sweden)

    Júlio Lobão

    2015-06-01

    Full Text Available In this article, we investigate the efficiency of the top tennis betting market worldwide using an original database from the Betfair betting exchange. Usually, the results show that the prices have made up a good forecast on the outcome of the matches. Nevertheless, there are evidences that the punters react poorly to the information (which is consistent with the conservatism and anchoring biases and that they assign a high gain probability to any players who happens to be dominating the match (consistent with the representativeness bias. Several lucrative betting strategies were found, which puts in check the efficiency of the reviewed betting market.

  9. Temporal Trends in Percutaneous Coronary Intervention Associated Acute Cerebrovascular Accident (From the 1998–2008 Nationwide Inpatient Sample [NIS] Database)

    Science.gov (United States)

    Shivaraju, Anupama; Yu, Changhong; Kattan, Michael W.; Xie, Hui; Shroff, Adhir R.; Vidovich, Mladen I.

    2014-01-01

    Acute cerebrovascular accident (CVA) after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) and coronary artery disease (CAD) is associated with high morbidity and mortality. Nationwide Inpatient Sample from 1998 to 2008 was utilized to identify 1,552,602 PCIs performed for ACS and CAD. We assessed temporal trends in the incidence, predictors and prognostic impact of CVA in a broad range of patients undergoing PCI. The overall incidence of CVA was 0.56% (95% confidence interval (CI), 0.55%–0.57%). The incidence of CVA remained unchanged over the study period (adjusted p for trend = 0.2271). The overall mortality in the CVA group was 10.76% (95% CI, 10.1%–11.4%). The adjusted odds ratio (OR) of CVA for in-hospital mortality was 7.74 (95% CI, 7.00–8.57; pCVA included older age (OR, 1.03, 95% CI, 1.02–1.03; pCVA achieved a concordance index of 0.73 and was well calibrated. In conclusion, the incidence of CVA associated with PCI has remained unchanged from 1998–2008 in face of improved equipment, techniques and adjunctive pharmacology. The risk of CVA associated in-hospital mortality is high; however, this risk has declined over the study period. PMID:24952927

  10. Substrate Recognition and Specificity of the NisB Protein, the Lantibiotic Dehydratase Involved in Nisin Biosynthesis

    NARCIS (Netherlands)

    Mavaro, Antonino; Abts, Andre; Bakkes, Patrick J.; Moll, Gert N.; Driessen, Arnold J. M.; Smits, Sander H. J.; Schmitt, Lutz

    2011-01-01

    Nisin is a posttranslationally modified antimicrobial peptide containing the cyclic thioether amino acids lanthionine and methyllanthionine. Although much is known about its antimicrobial activity and mode of action, knowledge about the nisin modification process is still rather limited. The dehydra

  11. DETECÇÃO E GENOTIPAGEM DE PAPILOMAVÍRUS HUMANO EM TUMORES DE PÊNIS

    OpenAIRE

    Sousa, Antoniella Fernanda Mendanha

    2008-01-01

    O Câncer é uma conseqüência de alterações genéticas ou epigenéticas em uma variedade dos genes que são fundamentais ao processo de crescimento, proliferação, diferenciação e morte programada da célula. Atualmente, essa doença, configura-se um dos principais problemas da saúde mundial, e no Brasil, representa a segunda causa de óbito na população adulta. O câncer de pênis é um tipo raro de neoplasia, que acomete indivíduos de países subdesenvolvidos com baixo nível social e precários hábitos d...

  12. On the significance of natural gas with regard to tomorrow's customer target group; Zur Bedeutung von Erdgas in der Kundenzielgruppe von morgen

    Energy Technology Data Exchange (ETDEWEB)

    Halstrup, Dominik [Hochschule Osnabrueck (Germany). Professur fuer BWL und Strategisches Management; Groeblinghoff, Sebastian [EVU, Essen (Germany); Walsh, Gianfranco [Koblenz Univ. (Germany). Inst. fuer Management

    2011-10-15

    Competition between the energy carriers in Germany's heating market has become harsher over the past years and is expected to grow still further. Successful customer acquisition and long-term customer retention will become increasingly important for natural gas supply companies. For this reason decision makers at public utilities that have a significant share of natural gas in their sales portfolio should have the foresight to ask themselves what sentiment tomorrow's home and house owners will have towards natural gas as an energy product as well as towards their company.

  13. Parameters of leisure mobility of elder people: The importance of settlement structures and automobile availability; Bestimmungsgroessen der Freizeitmobilitaet aelterer Menschen: Die Bedeutung von Siedlungsstrukturen und Pkw-Verfuegbarkeit

    Energy Technology Data Exchange (ETDEWEB)

    Scheiner, J. [Dortmund Univ. (Germany). Fakultaet Raumplanung, Verkehrswesen und Verkehrsplanung

    2005-07-01

    According to gerontological mobility research, car availability as well as appropriate settlement structures at the neighbourhood level are both playing a prominent role in the maintenance of mobility of elderly people. However, car availability is strongly connected to other individual attributes like age, health and gender. The paper investigates whether car availability and spatial context have an impact on leisure mobility of elderly people when socio-demographic and health factors are being controlled for. The paper is based on a standardised cross-sectional survey among n=4,500 residents of three different study areas in Germany. Leisure mobility was investigated with respect to out-of-home activity frequency, activity diversity, travel distance, existence of unfulfilled activity wishes, and leisure satisfaction. According to the results, leisure mobility is strongly associated with health, social networks, and socio-demographic characteristics. Only two mobility measures are positively associated with the availability of a private car. The spatial context does not have a significant influence on any mobility indicator. The results support the thesis that car availability is not a cause for mobility, but rather a result of a specific life situation, which is associated with a specific type of mobility. (orig.)

  14. Die regionalökonomische Bedeutung der Wissenschaft für das Ruhrgebiet - Hochschulen und außeruniversitäre Forschungseinrichtungen als Motor der regionalen Entwicklung

    Science.gov (United States)

    Kriegesmann, Bernd; Böttcher, Matthias; Lippmann, Torben

    2016-08-01

    The Ruhr area has advanced to the largest university region in Germany - often unnoticed within and outside. At the same time scientific institutions have become a major economic factor. Because of the higher and extra-university research institutions about 2.5 billion euros are effective as a demand potential in the region. 1.7 billion euros of this amount are directly associated with investments and operating expenditures of the scientific institutions as well as consumptions of employees and students. Additional 770 million euros result in revenues of many branches such as trade, housing, gastronomy sector, handcraft industry etc. It should not be underestimated that higher and extra-university research institutions generate with their research activities particular funding from the European Union or the rest of Germany for benefit of the region. Each euro spent by the state government for basic funding creates 39 cents third-party funding. These regional-economic effects result in noticeable employment impacts within the region. Around 25,000 people are directly employed in higher and extra-university research institutes or student unions (Studierendenwerke), about 22,000 jobs in other economic sectors are ensured or created by the induced demand. Science has thus become an important economic factor and represents an essential counterbalance to employment decline in shrinking industries of the region. The specific inclusion of science in a regional development strategy and targeted relining with appropriate measures to strengthen the science creates therefore an effective starting point for the design of structural change.

  15. The role of Sesta-Mibi-SPECT in angiographically documented coronary heart disease. Zur Bedeutung der Sesta-Mibi-SPECT bei angiographisch dokumentierter koronarer Herzerkrankung

    Energy Technology Data Exchange (ETDEWEB)

    Vogt, H. (Inst. fuer Nuklearmedizin, 1. Medizinische Klinik, Zentralklinikum Augsburg (Germany)); Graf, G. (Inst. fuer Nuklearmedizin, 1. Medizinische Klinik, Zentralklinikum Augsburg (Germany)); Krawietz, W. (Inst. fuer Nuklearmedizin, 1. Medizinische Klinik, Zentralklinikum Augsburg (Germany)); Bolte, H.D. (Inst. fuer Nuklearmedizin, 1. Medizinische Klinik, Zentralklinikum Augsburg (Germany)); Heidenreich, P. (Inst. fuer Nuklearmedizin, 1. Medizinische Klinik, Zentralklinikum Augsburg (Germany))

    1994-04-01

    131 patients were studied to compare the results of 99mTc-Mibi-SPECT with coronary angiography (CAG). 127 patients remained for final evaluation. A scar was falsely diagnosed in 17. 13 patients had a normal CAG and pathologic Sesta-Mibi-SPECT. 5 of them suffered from cardiomyopathy. 2 patients have had a myocarditis, at 2 others a PTCA was perfomred. 1 patient had a 20% LCA-stenosis and another one a left ventricular hypertrophy. Two times the reason for the pathologic Sesta-Mibi-SPECT could not be found. 1 patient had a normal Sesta-Mibi-SPECT despite of a pathologic CAG, angina pectoris and pathologic ECG. We got congruent results in 113 patients. 7 patients showed a left bundle branch block (LBBB), in 5 of them the Mibi-SPECT corresponded well with the CAG. 2 patients with dilated cardiomyopathy and no CHD showed an exercise induced ischemia in the anteroseptal wall. In patiens with angiographically documented CHD Sesta-Mibi-SPECT gives reliable diagnostic information concerning the myocardial perfusion. (orig./MG)

  16. Die Bedeutung der Chemokinrezeptoren CCR7 und CXCR4 sowie des CCR7-Liganden CCL21 für die Ausbreitung des duktalen Adenokarzinoms des Pankreas

    OpenAIRE

    Frank, Sunna

    2010-01-01

    In dieser Arbeit wurde ein Kollektiv von duktalen Adenokarzinomen des Pankreas hinsichtlich einer Expression der Chemokinrezeptoren CCR7 und CXCR4 sowie des CCR7-Liganden CCL21 untersucht. Es konnte ein Zusammenhang zwischen der lymphatischen Ausbreitung des Karzinoms und der CCR7-Expression sowie ein Zusammenhang zwischen der CXCR4-Expression und hohen klinischen Tumorstadien dargestellt werden. Weiterhin wird die Expression CCL21 in intra- und peritumoralen Lymphgefäßen sowie in entzündeten...

  17. The significance of microRNAs or the cellular response in endothelium cells; Die Bedeutung von microRNAs fuer die zellulaere Strahlenantwort in Endothelzellen

    Energy Technology Data Exchange (ETDEWEB)

    Moertl, Simone; Heider, Theresa [Helmholtz Center Muenchen, Neuherberg (Germany). Arbeitsgruppe Clinical Radiation Biology

    2016-08-01

    Ionizing radiation causes a variety of cell damages. Several cell constituents like DNA, mitochondria, proteins or membranes are affected. Cells have developed numerous and cross-linked radiation response processes for counteraction. In case of failure of the repair mechanism cell proliferation or cell death are the consequences. Many proteins in these processes are controlled by microRNAs (miRNAs). The accurate knowledge of miRNA functions is therefore importance not only for radiation protection but also the therapeutic use of ionizing radiations.

  18. Klimawandel und Gender: Untersuchung der Bedeutung von Geschlecht für die soziale Vulnerabilität in überflutungsgefährdeten Gebieten

    OpenAIRE

    Chavez Rodriguez, Libertad

    2013-01-01

    The dissertation examines the significance of gender and gender relationships in connection with other socio-economic characteristics for the social vulnerability to climate change-related extreme weather events. What options for environmental political action for DRM can be derived from the answers to that question? Empirical research was conducted in two flood prone areas, in the Elbe riverside region of Low Saxony, Germany and in the northern coast of Yucatán, Mexico. The collection of emp...

  19. European Consciousness: Towards Defining a Complex Concept and Its Educational Significance (Europaisches Bewusstsein: Zur Definition Eines Vielschichtigen Begriffes und Seiner Bildungstheoretischen Bedeutung)

    Science.gov (United States)

    Jobst, Solvejg

    2005-01-01

    The present study aims at a definition of "European consciousness". In particular, it draws on Henri Tajfel's theory of social identity as well as Roland Wakenhut's and Jutta Gallenmuller's moral determination of national consciousness. European consciousness is then defined as a sense of belonging which, depending on certain…

  20. Criminal implication of sponsoring in medicine: legal ramifactions and recommendations; Strafrechtliche Bedeutung des Sponsorings in der Medizin: Gesetzliche Rahmenbedingungen und Handlungsempfehlungen

    Energy Technology Data Exchange (ETDEWEB)

    Mahnken, A.H.; Guenther, R.W. [Klinik fuer Radiologische Diagnostik, Universitaetsklinikum Aachen (Germany); Theilmann, M. [Rechtsanwalt Martin Theilmann, Osnabrueck (Germany); Bolenz, M. [Fakultaet Wirtschafts- und Sozialwissenschaften, Fachhochschule Osnabrueck (Germany)

    2005-08-01

    As a consequence of the so-called ''Heart-Valve-Affair'' in 1994, the German public became aware of the potential criminal significance of industrial sponsoring and third-party financial support in medicine. Since 1997, when the German Anti-Corruption Law came into effect, the penal regulations regarding bribery and benefits for public officers were tightened. Due to the lack of explicit and generally accepted guidelines in combination with regional differences of jurisdiction, there is a lingering uncertainty regarding the criminal aspects of third-party funding and industrial sponsoring. The aim of this review is to summarize the penal and professional implications of third-party funding and sponsoring in medicine including recent aspects of jurisdiction. The currently available recommendations on this issue are introduced. (orig.)

  1. THE TURKIC LANGUAGES AND THEIR DEMOGRAPHIC IMPORTANCE DIE TURKSPRACHEN UND IHRE DEMOGRAPHISCHE BEDEUTUNG TÜRK DİLLERİ VE DEMOGRAFİK ÖNEMİ

    Directory of Open Access Journals (Sweden)

    İhsan Yılmaz BAYRAKTARLI

    2012-06-01

    Full Text Available The paper discusses the Turk languages, respectively the Altai languages from the important aspects as classification, transcription as well as distribution and history. The family relationships among the Ural-Altaic are also an important aspect. The classification, distribution and number of speaker of the Uralic is also anchored, intentional and irrespective of the existence of a relationship.Especially the classification of the ur- Altaic and its derivates are treated illustratively. Hereby, perspectives different experts are briefly outlined. These perspectives as well as the illustrations are based on the turkology, respectively on the accepted sources in the field of UralAltaic.The paper comprises new constructive ideas as well as contrastive comparisons. The linguistic records of experts were treated preferential. Despite intented to analyse the development, distribution and classification of the Ural-Altaic language group in general, the Turk languages are favored due to their spread, high number of speaker and their varying transcription. Furthermore, the demographic significance of the turk languages are not fully understood. Turkologists treat this subject justifiably subject-specific and mostly very complicated. Hence, the paper is expected to fill a gap through its different perspective Bu çalışmada Türk Dillerinin, daha doğrusu Altay Dilllerinin tarihi, yayıldığı coğrafya, bu dillerin yazı sistemleri ve sınıflandırılmaları ve bu konuda yapılan tartışmalar bütün yönleri ile incelenmektedir. Aynı zamanda altay ve ural dil gruplarının akrabalığı konu edilmektedir. Burada Ural dil grubu ile Altay dil grubu kökenleri itibari ile sanki ayni bir İlk-Dilden geliyormuş gibi sınıflandırıldı, yayıldığı coğrafya ve bu dilleri konuşanların sayısal dağılımı da aynı şekilde bu çalışmada incelendi. Özellikle İlk-Altayca ve onun türevlerinin sınıflandırılması çizimlerle desteklendi. Çizelgelerin ortaya çıkarılmasında değişik kanatlardan bilim adamlarının fikirleri önemle dikkate alındı. Çizimler olsun diğer değerlendirmeler olsun hepsi Ural-Altay dilleri alanında uzman bilim adamlarının düşüncelerine dayandırıldı. Çalışma bir çok yeni ve yapıcı fikri ortaya koyarken aynı zamanda da konuyla alakalı muhalif fikirlere de yeterince yer vermektedir. Ural ve Altay Dil gruplarının akrabalık konusunda yapılan tartışmaların önemine binaen, lenguistik delillere öncelikle yer verilmiştir. Japonya’dan Orta-Avrupa’ya kadar geniş bir coğrafyaya yayılmış olan bu dillerin önemi yeterince anlaşılmadığı ortadadır. Genelde Türkologların özellikle de batılı Türkologların yapmış olduğu çalışmalar, çoğunlukla uzman ve karmaşık alanlarda kaldığından, bu çalışma daha klasik bir konuyu ve bahsi geçen dil gruplarının demografik yapısını incelemekle önemli bir boşluğu dolduracaktır

  2. Intrazelluläre Lokalisation und synaptische Ausschüttung der Neurotrophine in hippokampalen Neuronen und die Bedeutung von BDNF bei hippokampaler synaptischer Plastizität

    OpenAIRE

    Brigadski, Tanja

    2007-01-01

    Die Mitglieder der Neurotrophin-Familie (NGF, BDNF, NT-3 und NT-4) sind sekretierte Neuropeptide, die eine bedeutende Rolle bei der Entwicklung von Nervenzellen und bei der Modulation der synaptischen Transmission spielen. Wenngleich eine aktivitätsabhängige Sekretion von BDNF bereits gezeigt werden konnte, wurden die subzelluläre Expression und die Ausschüttung der anderen Neurotrophine bislang nur unzureichend charakterisiert. Um die Expression und die Ausschüttung aller Neurotrophine un...

  3. Natural radionuclides in urine and feces samples and their importance for incorporation monitoring; Natuerliche Radionuklide in Urin- und Stuhlproben und deren Bedeutung in der Inkorporationsueberwachung

    Energy Technology Data Exchange (ETDEWEB)

    Froning, Martina; Burow, Mechthild; Droop, Philipp; Laumen-Sentis, Sandra; Zoriy, Myroslav [Forschungszentrum Juelich GmbH (Germany)

    2017-08-01

    Incorporation monitoring is performed for personnel dealing with open radioactive materials if incorporation cannot be excluded. Besides occupational exposure everybody is exposed to natural radioactivity. For the interpretation of occupational incorporation or in case of a radiation accident it is necessary to know the diet related share of natural radioactivity.

  4. Transport of sediments in Himalaya-Karakorum and its influence on hydropower plants; Sedimenttransportprozesse im Himalaya-Karakorum und ihre Bedeutung fuer Wasserkraftanlagen

    Energy Technology Data Exchange (ETDEWEB)

    Palt, S.M.

    2001-07-01

    In the present study the sediment transport processes in alpine mountain areas and their impact on hydropower development projects are investigated. The aim of the present work is to contribute to the understanding of the transport process system, which is characterized by high magnitude-low frequency - events, to ensure an appropriate layout of high head hydropower projects in mountain regions. The sediment transport in large areas in the macro scale is triggered by natural hazards, such as earthquakes, rock slides, earth movements, debris flows, glacial lake outbursts and floods. The basic principle of complex transport processes in this scale is described and explained on the example of the Himalaya-Karakorum-region. The sediment transport process in the smaller scale, so called meso scale, is investigated by means of extensive field measurements at river reaches of 16 different mountain rivers of a 80000 km{sup 2} large project area. The measurements include topographic survey works and measurements of discharge, bed load and suspended load. Since the conditions of mountain rivers in terms of size of bed material as well as available flow velocities can be considered as extreme, an appropriate bed load sampler named B-69 was developed, constructed and used in the field. Moreover the hydraulic as well as the sedimentological efficiency of the sampler was tested in the laboratory tests. Due to the nice performance of the bed load sampler B-69 at high flow velocities it might be useful for flood conditions in gravel-bed rivers in other parts of the world as well. Based on the results of the study the parameter of the river slope can be considered as the most important one for the characteristics of the morphology, the flow conditions, the bed stability as well as the bed load transport in steep mountain rivers. With increasing slope morphological structures in the longitudinal direction will develop from flat bed conditions. The so called step-pool-systems consist of a cascade of staircase local falls. Their distance in-between the falls as well as their height difference at the steps is strongly depending on the river slope. (orig.) [German] Die vorliegende Arbeit beschaeftigt sich mit den Sedimenttransportprozessen in alpinen Gebirgsregionen und deren Auswirkungen auf Wasserkraftanlagen. Ziel der Arbeit ist es, zum Verstaendnis des natuerlichen Sedimenttransportes mit der fuer Gebirgsregionen typischen Charakteristik von 'High Magnitude-Low Frequency - Prozessen' beizutragen, um eine den Transportverhaeltnissen geeignete Auslegung von geplanten Wasserkraftanlagen zu finden. Am Beispiel der Gebirgsregion des Himalaya-Karakorums werden die komplexen Transportvorgaenge im grossraeumigen Raum des Makromassstabes erlaeutert. Dabei wird auf die Massentransporte eingegangen, die durch Naturgefahren wie Erdbeben, Felsgleitungen, Erdrutsche, Muren, Gletscherbrueche und Hochwaesser ausgeloest werden. Der Schwerpunkt der Arbeit liegt in der Durchfuehrung von umfangreichen Naturmessungen im untergeordneten Raum des Mesomassstabes im Bereich von einzelnen Flussabschnitten. Die Naturmessungen umfassen morphologische und topographische Aufnahmen, Abfliessmessungen, Geschiebe- sowie Schwebstoffmessungen an 16 Gebirgsfluessen eines insgesamt 80000 km{sup 2} grossen Projektgebietes im Himalaya-Karakorum. Aufgrund der extremen Verhaeltnisse der Gebirgsfluesse der Region hinsichtlich vorhandener Korngroesse des Bettmaterials sowie die Groessenordnung der Fliessgeschwindigkeiten wurde fuer die Untersuchungen eigens der mobile Geschiebesammler B-69 entwickelt, gebaut und auf seine hydraulische und sedimentologische Effizienz hin geprueft. Der Einsatz des B-69 hat sich im Feld bewaehrt und ist fuer weitere Anwendungen bei Hochwasserereignissen in kiesfuehrenden Fluessen geeignet. Als massgebender Parameter zur Beschreibung der Morphologie, der Stroemung, der Sohlenstabilitaet und des Geschiebetransportes von Gebirgsfluessen im Mesomassstab konnte das Gefaelle I festgestellt werden. Das Gefaelle ist bestimmend fuer die Ausbildung der morphologischen Strukturen im Laengsprofil, die sich mit zunehmendem Gefaelle von der ebenen Sohle (I<1%) als eine Sequenz von lokalen Abstuerzen, auch als Step-Pool-Systeme bezeichnet, ausbildet. Je steiler die Neigung des Gerinnes desto geringer wird der Abstand der Step-Pools in Laengsrichtung und desto groesser wird der Hoehenunterschied an der einzelnen Struktur. (orig.)

  5. ORGANISATION 2020: EMPIRISCHE UNTERSUCHUNG DER HEUTIGEN UND ZUKÜNFTIGEN BEDEUTUNG VON ORGANISATIONSTHEMEN FÜR GARTENBAUUNTERNEHMEN SOWIE DEREN WAHRGENOMMENE KOMPETENZ

    OpenAIRE

    Meyerding, Stephan

    2015-01-01

    Der Strukturwandel, Umweltthemen und die Konzentration der Branche verändern die Wettbewerbslandschaft im deutschen Gartenbau. Im Vordergrund der Organisationsgestaltung stehen daher bei vielen Gartenbauunternehmen Umweltauflagen und –kosten, unternehmensweite Kostensenkung und Restrukturierung. Wie in anderen Bereichen der Unternehmensführung ändern sich auch in der Organisationsgestaltung immer wieder die Schwerpunkte. Die vorliegende Studie hat zum Ziel, Themen zu identifizieren, welche di...

  6. Resonance vibrations of cylinder charge of Diesel engines and their importance for combustion noise. Resonanzschwingungen der Zylinderladung von Dieselmotoren und ihre Bedeutung fuer das Verbrennungsgeraeusch

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, M.H.

    1987-09-10

    Measurements of the pressure distribution in the gas charge of the combustion space were made on Diesel engines, in a combustion chamber and on a test rig. They describe the significance of inherent resonance vibrations of the gas charge for Diesel engine combustion and for engine acoustics. There are reports on the known principal conditions (inherent vibration pressure amplitude, degree of excitation, combination of several part combustion chambers, wavelengths, phase position) and on the digital analysis (computer-aided) of combustion space inherent vibrations. Data are given on part components of engine noise, possible excitation by pressure variations in the cylinder charge, the theory of combustion space resonance vibration, the conversion of gas pressure variations into combustion noise and investigations on the running engine. (HWJ).

  7. Grüne Infrastruktur in den Städten Nordrhein-Westfalens. Bedeutung als Standortfaktor und Einfluss auf das Standortmarketing

    Science.gov (United States)

    Schäffer, Ina

    2016-06-01

    Hardly any other city in North Rhine-Westphalia has such a green image as the city of Münster. It embodies the image of a livable city in Germany. Other North Rhine-Westphalian cities also work on their external perception and are approaching the task of getting a greener image for themselves in many ways. A central question is how it is done precisely and whether urban green infrastructure can be a locational factor to affect location-based marketing. This article deals with the strategies of various cities in North Rhine-Westphalia.

  8. Die zentrale Bedeutung des "Osteoklasten-differenzierenden Faktors" und seines Antagonisten, des "Osteoklasten-inhibierenden Faktors" für das Verständnis der Osteoklastogenese

    Directory of Open Access Journals (Sweden)

    Gruber R

    1999-01-01

    Full Text Available Osteoklasten sind mehrkernige, den Knochen abbauende Riesenzellen, die durch Differenzierung hämatopoetischer Vorläuferzellen der Monozyten/Makrophagenlinie entstehen können. Die Zell-Zell Interaktion zwischen den Osteoklastenvorläufern und der aus Stromalzellen bzw. Osteoblasten gebildeten "Mikroumgebung" ist für die Entstehung der Osteoklasten essentiell. Es wurde daher angenommen, daß die Synthese eines membrangebundenen "Osteoklasten-differenzierenden Faktors" (ODF in den Stromal/Osteoblasten als Antwort auf Hormone und lokale Faktoren ausgelöst wird (s. Abb. 1. Dieses Protein wurde unlängst charakterisiert und als ODF und/oder "Osteoprotegerin Ligand" (OPGL bezeichnet. ODF/OPGL ist ein Mitglied der "Tumor-Nekrose-Faktor" (TNF Ligandenfamilie und ist mit zwei weiteren, die Funktion der dendritischen Zellen verstärkenden Proteinen, genannt RANKL und TRANCE, identisch. Eine organspezifische Expression konnte im trabekulären Knochen, dem Knochenmark, aber auch in der Milz, dem Thymus und der Lunge beobachtet werden. Ein weiteres, erst kürzlich beschriebenes Protein ist "Osteoprotegerin" (OPG, welches auch als "Osteoklastogenese-inhibierender Faktor" (OCIF bezeichnet wird. OPG/OCIF kann die Osteoklastenneubildung durch die direkte, hoch affine Bindung an den ODF/OPGL der Stromal/Osteoblasten unterbinden. Dieses nicht-membrangebundene Mitglied der TNF-Rezeptor Superfamilie wird ubiquitär exprimiert. Eine spezifische Geninaktivierung zeigt im Tiermodell die typischen Merkmale der "Osteoporose", während die erhöhte Expression zu "Osteopetrose" führt. Grundsätzlich betrachtet, erfolgt durch OPG/OCIF eine Blockierung der osteoklastendifferenzierenden Effekte von ODF/OPGL. Es ist daher anzunehmen, daß diesen extrazellulären Faktoren eine Schlüsselfunktion in der Entwicklung von Osteoklasten zukommt.

  9. EC regulations for refrigeration and air conditioning. National and international law; Bedeutung der Europaeischen Richtlinien fuer den Kaelte- und Klimaanlagenbauer. Nationales und Internationales Recht

    Energy Technology Data Exchange (ETDEWEB)

    Hainbach, C. [Institut fuer Kaelte-, Klima-, Energie-Technik GmbH, Essen (Germany)

    2002-10-01

    Producers and importers of technical appliances for the German market are subject to German laws, ordinances and technical rules. However, European law applies as well, which may present difficulties in practice as it will be unclear which standards and technical rules should apply in a given case. [German] Fuer Hersteller und Importeure von technischen Erzeugnissen auf dem deutschen Markt gelten grundsaetzlich die nach deutschem Recht erlassenen Gesetze, Verordnungen und technischen Regeln. Hierbei ist es aber nicht einfach, eine Abgrenzung zu den nach europaeischem Recht (EWG-Vertrag) erlassenen Richtlinien zu finden. Da nach europaeischen Vorschriften im Bereich der Technik noch kein abschliessendes Regelwerk zur Verfuegung steht, ergibt sich somit die Schwierigkeit, welche Normen, Standards und sonstigen technischen Regeln fuer die Beurteilung von technischen Erzeugnissen heranzuziehen sind. (orig.)

  10. Die Bedeutung Subjektiver Elternschaftskonzepte fur Erziehungsverhalten und elterliche Partnerschaft. Ein Uberblick uber neuere Forschungsergebnisse (The Significance of Subjective Concepts of Parenthood for Educational Behavior and Parental Partnership).

    Science.gov (United States)

    Kalicki, Bernhard

    2003-01-01

    Outlines the subjective concept of parenthood as the personal interpretation of parental responsibility, distinguishing it from related theoretical concepts. Discusses, against the background of theoretical models and empirical findings, the relationship of the parenthood concept with the parents' actual educational behavior. Suggests ways to…

  11. S3 guideline. Diagnosis and treatment of gastric carcinoma. Relevance for radiologic imaging; Aktualisierte S3-Leitlinie zur Diagnostik und Therapie des Magenkarzinoms. Bedeutung fuer die Radiologische Diagnostik

    Energy Technology Data Exchange (ETDEWEB)

    Grenacher, L.; Schwarz, M.; Kauczor, H.U. [Universitaetsklinikum Heidelberg (Germany). Abt. Diagnostische und Interventionelle Radiologie; Lordick, F. [Staedtisches Klinikum Braunschweig (Germany). Medizinische Klinik III; Krause, B. [Universitaetsklinikum Rostock (Germany). Klinik und Poliklinik fuer Nuklearmedizin; Roecken, C. [Kiel Univ. (Germany). Inst. fuer Pathologie; Moenig, S. [Universitaetsklinikum Koeln (Germany). Klinik fuer Allgemein-, Viszeral- und Tumorchirurgie; Ebert, M. [Universitaetsklinikum Mannheim (Germany). Medizinische Klinik II; Jenssen, C. [Krankenhaus Maerkisch Oderland, Wriezen (Germany). Innere Medizin; Moehler, M. [Universitaetsmedizin Mainz (Germany). I. Medizinische Klinik und Poliklinik

    2012-08-15

    The new German S3 guideline regarding stomach cancer includes a variety of innovations with respect to the diagnosis and treatment of adenocarcinoma of the stomach and the esophagogastric junction. The guideline has been strongly supported by the 'oncology' guidelines program consisting of the 'Deutsche Krebshilfe' and the German Cancer Society and the AWMF (Dr. M. Follmann). This guideline contains evidence-based treatment recommendations and quality indicators for guideline implementation and evaluation in order to improve broad medical care and to facilitate development and subsequent adjustment. The purpose of this article is to introduce the innovations with regard to radiological diagnosis and to discuss the latest literature on the subject. (orig.)

  12. Welche Bedeutung haben die Neurowissenschaften für die Fremdsprachendidaktik? : eine pro- und retrospektive Studie in Bezug auf Theorie und Praxis

    OpenAIRE

    Teepe, Harald

    2005-01-01

    Today, there is growing demand that education should be integrated with relevant neuroscientific findings to answer questions of upbringing and learning. This approach is considered both forward-looking and necessary internationally. For example, in 2004 the OECD organised conferences under the title “Brain and Learning” in several countries. For quite a time the discipline of foreign language teaching (FLT) is attempting to integrate findings of neuroscience with its own theories and recomme...

  13. In-vitro examinations and patient examinations by MR: Significance of metal implants. In-vitro- und Patientenuntersuchungen mittels MRT: Bedeutung metallischer Implantate

    Energy Technology Data Exchange (ETDEWEB)

    Grebmeier, J.; Roedl, W. (Erlangen-Nuernberg Univ., Erlangen (Germany, F.R.). Zentrum Innere Medizin); Weikl, A. (Erlangen-Nuernberg Univ., Erlangen (Germany, F.R.). Medizinische Klinik 2 mit Poliklinik); Glueckert, K. (Waldkrankenhaus St. Marien, Erlangen (Germany, F.R.). Orthopaedische Klinik mit Poliklinik); Hofmann-Preiss, K. (Erlangen-Nuernberg Univ., Erlangen (Germany, F.R.). Chirurgische Klinik mit Poliklinik); Huk, W.J. (Erlangen-Nuernberg Univ., Erlangen (Germany, F.R.). Kopfklinikum); Wolf, F. (Erlangen-Nuernberg Univ., Erlangen (Germany, F.R.). Inst. und Poliklinik fuer Nuklearmedizin)

    1991-05-01

    This study presents the results of in-vitro and clinical experiences with metallic implants during MRT investigations. In-vitro temperature measurements of various implants showed little temperature rise depending on the shape and the orientation in the static magnetic field (max. 0.3deg C). Ferromagnetic forces could not be detected with these implants. In contrast, severe temperature increase (9.3deg C) was observed with an intratracheal spiral tube. Tubes of this type should not be used in MR imaging to avoid the risk of burning. 105 MR examinations were performed in patients with metallic implants (CNS shunts, aortocoronary bypass grafts, aortic-, mitral-prothesis, orthopedic implants, skin staples, shrapnels). Patients with vascular clips were accepted for MR imaging when the clips were non-ferromagnetic only. No adverse effects were observed in these patients. (orig.).

  14. Stadtgrün statt Stress. Eine epidemiologische Studie zur gesundheitlichen Bedeutung urbaner Ökosystemleistungen am Beispiel der Stadt Bonn

    Science.gov (United States)

    Ptock, Alexandra

    2016-06-01

    The study shows the relation between urban green and (urban) stress within the urban district Bonn, Germany. How do urban ecosystem services influence the subjective well-being? A triangulation of methods (site's inspections, online survey) was applied to collect data on the availability and state of urban green spaces regarding the urban district of Bonn and by whom, why and how often they are visited. Of special interest could be the ecological state of the green space. The ecological state of green spaces in Bonn was assessed and connected to the results of the online survey. Thus, health effective potentials of urban green can be given. Main advantages were proved by an excellent network of green infrastructure as well as big green spaces or rather open catchment areas.

  15. Die regionalökonomische Bedeutung der Wissenschaft für das Ruhrgebiet. Hochschulen und außeruniversitäre Forschungseinrichtungen als Motor der regionalen Entwicklung

    Science.gov (United States)

    Kriegesmann, Bernd; Böttcher, Matthias; Lippmann, Torben

    2016-09-01

    The Ruhr area has advanced to the largest university region in Germany - often unnoticed within and outside. At the same time scientific institutions have become a major economic factor. Because of the higher and extra-university research institutions about 2.5 billion euros are effective as a demand potential in the region. 1.7 billion euros of this amount are directly associated with investments and operating expenditures of the scientific institutions as well as consumptions of employees and students. Additional 770 million euros result in revenues of many branches such as trade, housing, gastronomy sector, handcraft industry etc. It should not be underestimated that higher and extra-university research institutions generate with their research activities particular funding from the European Union or the rest of Germany for benefit of the region. Each euro spent by the state government for basic funding creates 39 cents third-party funding. These regional-economic effects result in noticeable employment impacts within the region. Around 25,000 people are directly employed in higher and extra-university research institutes or student unions (Studierendenwerke), about 22,000 jobs in other economic sectors are ensured or created by the induced demand. Science has thus become an important economic factor and represents an essential counterbalance to employment decline in shrinking industries of the region. The specific inclusion of science in a regional development strategy and targeted relining with appropriate measures to strengthen the science creates therefore an effective starting point for the design of structural change.

  16. The increasing meaning of industrial communication. New chances and challenges for systems and components; Die zunehmende Bedeutung der industriellen Kommunikation. Neue Moeglichkeiten und Herausforderungen fuer Systeme und Komponenten

    Energy Technology Data Exchange (ETDEWEB)

    Kegel, Gunther [Pepperl+Fuchs GmbH, Mannheim (Germany)

    2009-07-01

    In process control, data are exchanged vertically from the fi eld level to the control system and horizontally within the process control levels as well as within neighboring phases of the life cycle. Open, scalable system architectures demand standardized communication structures that have adjusted to the increasing requirements to communication in automation of plants of process industry in the last decades. Technologically related systems and solutions of other application fi elds have influenced especially the communication within process control. In the near future, Ethernet applications and wireless communication of other domains are capable to be applied in process engineering. The paper deals with the history of recent communication standards and topologies and tries to give an outlook on the meaning of new technologies. Emphasis is placed on the physical layer, i.e. the communication structure. (orig.)

  17. Die Suche nach dem Glück in der deutschen Literatur. Zur Bedeutung der blauen Blume in Novalis’ Heinrich von Ofterdingen

    Directory of Open Access Journals (Sweden)

    Simone Malaguti

    2005-12-01

    Full Text Available Assim como Os sofrimentos do jovem Werther e Os anos de aprendizado de Wilhelm Meister de Goethe, o romance Heinrich von Ofterdingen de Novalis é representativo para a literatura alemã. Este romance é também significativo e conhecido pela sua flor azul, um motivo usado por Novalis nesse romance. O artigo analisa a flor azul como um símbolo da busca pela felicidade na literatura alemã. Para tal, os seguintes assuntos são levados em consideração: a conexão entre o homem e a natureza, a cor azul conforme os estudos de Goethe, a flor azul como um motivo da natureza e os sonhos de Heinrich.

  18. The increasing importance of power electronics; Die wachsende Bedeutung der Leistungselektronik. Stromerzeugung, -uebertragung und Stromverteilung sind heute ohne Silizium kaum denkbar

    Energy Technology Data Exchange (ETDEWEB)

    Baumberger, H.; Steimer, P. [ABB Schweiz AG, Turgi (Switzerland)

    2010-07-01

    This article takes a look at the importance today of silicon in power generation, power transmission and power distribution. Also, the importance of this semiconductor as an important component in systems that can increase the efficiency of power use is discussed. Various requirements placed on power electronics are examined, both in the areas of control and protection. The cooling required by such high-power semiconductors and the possibilities of realising it are discussed. Their use in the power generation area, for instance in wind power, photovoltaics and tidal power stations is reviewed, as are applications in pump-storage power stations. Along with power transmission applications, reactive power and energy storage applications are discussed. The article is rounded off with a review of the use of power electronics in consumer and industrial applications such as variable speed drives, mains voltage stabilisation and uninterruptible power supplies.

  19. A rectal balloon catheter as internal immobilization device for conformal radiotherapy of prostate cancer; Die Bedeutung eines Rektumballons als interne Immobilisation bei der konformalen Strahlentherapie des Prostatakarzinoms

    Energy Technology Data Exchange (ETDEWEB)

    Gerstner, N.; Wachter, S.; Dorner, D.; Goldner, G.; Colotto, A.; Poetter, R. [Universitaetsklinik fuer Strahlentherapie und Strahlenbiologie, Wien (Austria)

    1999-05-01

    Background: As known from the literature, prostate motion depends on different bladder and/or rectum fillings. The aim of this study was to analyze the influence of a rectum balloon catheter, used as an internal immobilization device, on prostate and rectum motion during the treatment course. Moreover we have analysed if the balloon enables an increase of the distance between the prostate and the posterior rectum wall. Results: An increase of the distance between the prostate and the posterior rectal wall of 8 mm was observed at the base of the prostate when using the rectum balloon. Moreover prostate motion in the ventrodorsal direction {>=}4 mm (1 SD) was reduced from 6/10 patients (60%) to 1/10 patients (10%) using the rectal balloon. In general, deviations in the latero-lateral and cranio-caudal directions were less (mean {<=} 2 mm, 1 SD), no difference between both examination series (with and without balloon) was observed. Conclusion: Rectal balloon catheter offers a possibility to reduce prostate motion and rectum filling variations during treatment course. In addition it enables an increase in the distance between prostate and posterior rectal wall, which could enable an improved protection of the posterior rectal wall. (orig./AJ) [Deutsch] Hintergrund: Die Lageveraenderung der Prostata, bedingt durch unterschiedliche Harnblasen- und Rektumfuellungen, wurde bereits in einigen Studien untersucht. Ziel dieser Studie war es, zu pruefen, ob durch die Anwendung eines Rektumballonkatheters als interne Immobilisation der Prostata eine Reduktion der Prostataeigenbeweglichkeit moeglich ist. Darueber hinaus wurde untersucht, inwieweit durch den Rektumballon der Abstand zwischen Prostata und Rektumhinterwand vergroessert werden kann. Ergebnisse: Durch die Anwendung des Rektumballons konnte der Abstand zwischen Prostata und Rektumhinterwand an der Prostatabasis im Mittel um 8 mm vergroessert werden. Insgesamt konnte durch den Rektumballon die Prostatabewegung in ventrodorsaler Richtung deutlich reduziert werden. Die Anzahl jener Patienten, bei denen eine ventrodorsale Bewegung der zentralen Prostata im Therapieverlauf {>=}4 mm (1 SD) beobachtet wurde, konnte durch die Anwendung des Rektumballons von 6/10 Patienten (60%) auf 1/10 Patienten (10%) reduziert werden. Die Lageveraenderungen der Prostata in laterolateraler und kraniokaudaler Richtung waren deutlich geringer als jene in ventrodorsaler Richtung (im Mittel {<=} 2 mm, 1 SD) und wurden durch den Rektumballon nicht beeinflusst. Schlussfolgerung: Die Anwendung des Rektumballons ermoeglicht eine Reduktion der Prostataeigenbeweglichkeit in ventrodorsaler Richtung im Sinne einer internen Immobilisation. Zusaetzlich wird eine Vergroesserung des Abstands zwischen Prostata und Rektumhinterwand erreicht, wodurch eine bessere Schonung der Rektumhinterwand moeglich scheint. (orig./AJ)

  20. Probability of involvement of the seminal vesicles in treatment of localized prostate cancer; Wahrscheinlichkeit des Samenblasenbefalls beim lokal begrenzten Prostatakarzinom. Bedeutung fuer die konformale Strahlentherapie

    Energy Technology Data Exchange (ETDEWEB)

    Feldmann, H.J.; Zimmermann, F. [Klinik und Poliklinik fuer Strahlentherapie und Radiologische Onkologie der Technischen Universitaet Muenchen (Germany); Breul, J. [Urologische Klinik der Technischen Universitaet Muenchen (Germany); Wachter, S. [Universitaetsklinik fuer Strahlentherapie, Allgemeines Krankenhaus Wien (Austria); Wiegel, T. [Abteilung fuer Strahlentherapie, Freie Universitaet Berlin (Germany)

    1998-11-01

    Purpose: The development of objective criteria for selecting patients for seminal vesicle irradiation on radical radiotherapy for prostate cancer will be important for successful planning of 3D conformal radiotherpy. Materials and methods: Based on morphometric studies from radical prostatectomy specimens, new imaging modalities with potential in the investigation of patients with gross seminal vesicle involvement and clinical factors with potential in the identification of patients with subclinical disease the development of objective guidelines is possible. Results: Clinical tumor stage as determined by digital rectal examination, diagnostic tumor biopsy (Gleason Score), and pretherapy serum prostate-specific antigen value were significant factors for the probability of involvement of seminal vesicles. Studies show that seminal vesicle involvement is unlikely if the PSA is < 4 ng/ml or 4 to 10 ng/ml and Gleason Score < 7 and stage {<=}T2b. In contrast, involvement of seminal vesicles is highly likely with levels above 20 ng/ml. In patients with PSA levels between 10 and 20 mg/ml and Gleason Score < 7 ultrasonographic findings with regard to tumor volume and localization will be useful to determine the extent of the target volume. For treatment planning a significant reduction in the volumes of irradiation to the rectum and bladder is evident when seminal vesicles were excluded. Conclusion: Prospective use of the objective criteria will be useful in the selection of patients for seminal vesicle involvement and should be an integral part in 3D conformal radiotherapy of prostate cancer. (orig.) [Deutsch] Hintergrund: Im Rahmen der konformalen Therapie des Prostatakarzinoms wird eine Dosiseskalation angestrebt. Damit die Dosisbelastung des Normalgewebes - insbesondere des Rektums - moeglichst gering gehalten werden kann, ist es notwendig, objektive Kriterien zu erarbeiten, wann auf eine Bestrahlung der Samenblasen verzichtet werden kann. Material und Methoden: Im Rahmen einer Literaturuebersicht wird anhand neuer Erkenntnisse ueber die zonale Anatomie der Prostata, verbesserte Moeglichkeiten der Bildgebung sowie der klinischen Risikofaktoren die Wahrscheinlichkeit fuer einen subklinischen Befall der Samenblasen erarbeitet. Ergebnisse: Die Wahrscheinlichkeit des Samenblasenbefalls ist abhaengig von der Lage des Tumors, dem klinischen Stadium, dem Grading bzw. Gleason-Score und dem initialen PSA-Wert. In folgenden Situationen betraegt die Wahrscheinlichkeit des Samenblasenbefalls weniger als 15%: PSA < 4 ng/ml oder PSA 4 bis 10 ng/ml und Gleason-Score < 7 und Stadium {<=}T2b. Bei PSA-Werten zwischen 10 und 20 ng/ml und einem Gleason-Score < 7 koennen in spezialisierten Zentren mittels endosonographischer Bestimmung des Tumorvolumens und der -lokalisation zusaetzlich Patienten mit einer geringen Befallswahrscheinlichkeit identifiziert werden. Schlussfolgerung: Die genannten Kriterien sind ausgesprochen hilfreich fuer die Identifikation von Patienten, bei denen auf eine Mitbestrahlung der Samenblasen verzichtet werden kann. Sie sollten daher integraler Bestandteil bei der konformalen Therapie des Prostatakarzinoms sein. (orig.)

  1. Die Bedeutung von Anerkennungserfahrungen in der Schule für die Ausprägung von Altruismus und Werten der Offenheit

    Directory of Open Access Journals (Sweden)

    Isabella Lussi

    2015-09-01

    Full Text Available Die Werteentwicklung gilt als eine bedeutende Aufgabe im Jugendalter. Die Schule stellt dabei neben der Herkunftsfamilie eine zentrale Sozialisationsinstanz dar. Unklar ist jedoch, welche schulischen Erlebnisse die Entwicklung von Werten beeinflussen. Basierend auf 20 biografisch-narrativen Interviews mit 19- bis 21-jährigen jungen Erwachsenen in der Schweiz verfolgte die hier berichtete Studie das Ziel, schulische Erlebnisse zu eruieren, die für die Entwicklung von Werten bedeutsam sind. Bei der Auswertung der Interviews wurde das narrationsanalytische Verfahren nach SCHÜTZE (1984 mit dem Kodierverfahren der Grounded-Theory-Methodologie nach STRAUSS (1998 [1994] und der qualitativen Typenbildung (KELLE & KLUGE 1999 kombiniert. Die Ergebnisse der Studie zeigen: Anerkennung (im Sinne von HONNETH 1992 stellt eine Kernkategorie in den sehr unterschiedlichen Schüler/innenbiografien dar, und sie ist eng verknüpft mit der Ausprägung individueller Werte von jungen Erwachsenen. Junge Erwachsene, die sich in der Schule geliebt, respektiert und wertgeschätzt fühlten, kombinieren Sicherheits- und Leistungswerte mit Offenheit und Toleranz. Ist die Schulzeit durch einen Mangel an Anerkennung geprägt, werden Sicherheits- und Leistungswerte priorisiert. Dies scheint darin begründet zu sein, dass Anerkennung eine Bedingung für Autonomie darstellt und für die Fähigkeit, vergangenen und aktuellen Erlebnissen Sinn zu verleihen. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1503328

  2. Kulturmorphologische, biochemische und molekularbiologische Untersuchungen zur Differenzierung Koagulase-negativer Staphylokokken, isoliert aus Hälftegemelksproben von Ziegen und deren Bedeutung für die Eutergesundheit

    OpenAIRE

    Ehrenberg, Andrea

    2011-01-01

    Alle laktierenden Ziegen aus 12 hessischen Milchziegen-Betriebe wurden über einen Zeitraum von 2 Jahren beprobt. 83,6 % der 2038 Hälftegemelksproben waren kulturell negativ. 10,7 % der bakteriologisch positiven Proben waren Koagulase-negative Staphylokokken. Zur KNS-Differenzierung wurden Kulturmorphologie, ID32 Staph-Test, in-vitro-Sensitivität gegenüber Antibiotika und die t-DNA-PCR angewandt. Keines dieser Verfahren konnte alleinig zur Identifizierung der KNS-Isolate erfolgreich angewandt ...

  3. Die Bedeutung Subjektiver Elternschaftskonzepte fur Erziehungsverhalten und elterliche Partnerschaft. Ein Uberblick uber neuere Forschungsergebnisse (The Significance of Subjective Concepts of Parenthood for Educational Behavior and Parental Partnership).

    Science.gov (United States)

    Kalicki, Bernhard

    2003-01-01

    Outlines the subjective concept of parenthood as the personal interpretation of parental responsibility, distinguishing it from related theoretical concepts. Discusses, against the background of theoretical models and empirical findings, the relationship of the parenthood concept with the parents' actual educational behavior. Suggests ways to…

  4. Die Bedeutung des Habitus-Konzepts für die Erforschung soziokultureller Unterschiede im Bereich der Medienpädagogik

    Directory of Open Access Journals (Sweden)

    Ralf Biermann

    2009-08-01

    Full Text Available In diesem Artikel geht es um die nähere Betrachtung, welche grundlegenden Schnittstellen sich zwischen medienpädagogischen Ansätzen und der Habitus- Theorie von Pierre Bourdieu ergeben. Basierend auf diesen Überlegungen werden Aspekte ausgearbeitet, die in medienpädagogischer Forschung und Praxis zur Beachtung soziokultureller Unterschiede Berücksichtigung finden können.

  5. The importance of research and development for the sustainable success of global automobile manufactures; Bedeutung von Forschung und Entwicklung fuer den nachhaltigen Erfolg der Automobilindustrie im globalen Wettbewerb

    Energy Technology Data Exchange (ETDEWEB)

    Weber, T. [DaimlerChrysler AG, Konzernforschung und Mercedes Car Group Entwicklung, Stuttgart (Germany)

    2007-07-01

    In recent years the German automotive industry has continually reduced the fuel consumption of new vehicles according their self commitment. The first pledge - to lower consumption by 15 per cent in the period from 1978 to 1985 - was fulfilled, as was the second pledge, to reduce by 2005 the fuel consumption of new vehicles by one quarter as compared to 1990 levels. We feel obliged to even in force our endeavors to reduce the consumption in the following years. The dimension of the challenge we're being confronted with, imperatively forces all the parties to achieve a comparable performance to reduce the CO{sub 2} emission. New materials and manufacturing processes, highly efficient development tools and above all shared know-how in the global knowledge network and in cooperations: this is all opening the door to an exciting future - a future in which we can meet the individual requirements of a mobile humanity with environment-friendly, practically accident-free vehicles and continue to enhance even further the fascination of driving. (orig.)

  6. Water transport by Na+-coupled cotransporters of glucose (SGLT1) and of iodide (NIS). The dependence of substrate size studied at high resolution

    DEFF Research Database (Denmark)

    Zeuthen, Thomas; Belhage, Bo; Zeuthen, Emil

    2005-01-01

    and osmosis at the membrane with diffusion in the cytoplasm. The combination of high resolution measurements and precise modelling showed that water transport across the membrane can be explained by cotransport of water in the membrane proteins and that intracellular unstirred layers effects are minute....

  7. DEVELOPMENT OF AN IN VITRO RADIOACTIVE IODIDE UPTAKE ASSAY (RAIU) WITH HUMAN NIS-EXPRESSING HEK293T-EPA CELL LINE

    Science.gov (United States)

    Many high-throughput screening (HTPS) assays are available in the US EPA ToxCast program for estrogen and androgen pathways; only a limited number of assays exist for thyroid pathways. One potential target of thyroid-disrupting chemicals is the active uptake of iodide into the t...

  8. 二硫化镍空心微球的制备和表征%Synthesis and Characterization of NiS2 Hollow Microspheres

    Institute of Scientific and Technical Information of China (English)

    王敏; 陈友存

    2008-01-01

    以NiCl2·6H2O和Na2S2O3·5H2O为原料,在150 ℃较低温度的水热条件下制备了NiS2空心微球,用XRD和SEM对产物进行了表征,NiS2粉体的X射线衍射的衍射峰均与标准衍射图一致(JCPDS:653 325,立方晶系,a=0.567 8 nm),SEM图表明产物是分散较好的空心微球,微球直径为2 μm,空心球壁厚为100 nm.并讨论了不同反应条件对产物的影响.

  9. DEVELOPMENT OF AN IN VITRO RADIOACTIVE IODIDE UPTAKE ASSAY (RAIU) WITH HUMAN NIS-EXPRESSING HEK293T-EPA CELL LINE

    Science.gov (United States)

    Many high-throughput screening (HTPS) assays are available in the US EPA ToxCast program for estrogen and androgen pathways; only a limited number of assays exist for thyroid pathways. One potential target of thyroid-disrupting chemicals is the active uptake of iodide into the t...

  10. SISTEMA DE PREPARAÇÃO DESPORTIVA NO TÊNIS DE CAMPO PRATICADO POR JOVENS: "ESTRUTURA DO TREINO NO PERÍODO PREPARATÓRIO"

    Directory of Open Access Journals (Sweden)

    M. I. Shmagina

    2008-07-01

    Full Text Available Este estudo teve como objetivo principal, verificas o nível de aptidão física dos desportistas jovens da modalidade de tênis no período preparatório, período este que é de suma importância no desenvolvimento do treinamento de jovens. O trabalho desenvolveu-se em uma pequena cidade próxima de Moscou – Rússia onde se reuniu um grupo de tenistas jovens de nível internacional, na faixa etária de 10 – 13 anos de ambos os sexos, os quais durante o período de preparação, que durou cerca de um mês e meio, mantiveram-se em regime de internato. Inicialmente, os garotos foram submetidos a uma bateria de testes específicos de tênis de campo, reconhecidos pelo Ministério do Desporto da Rússia. Baseando-se nos resultados colhidos foi estruturado todo o processo de preparação no período preparatório, cujo objetivo principal foi o desenvolvimento das qualidades físicas. O período foi dividido em três etapas e em cada etapa os garotos foram reavaliados como o mesmo protocolo de testes. Os resultados obtidos nos permitiram sugerir um modelo de estruturação do processo do treino de tenistas jovens no período preparatório bem como uma bateria de testes que venha diagnosticar as qualidades físicas específicas do tênis de campo praticado por jovens na faixa etária de 10 – 13 anos.

  11. Synthesis, spectral, structural and computational studies on NiS4 and NiS2NP chromophores: Anagostic and C-H⋯π (chelate) interactions in [Ni(dtc)(PPh3)(NCS)] (dtc = N-(2-phenylethyl)-N-(4-methoxybenzyl)- dithiocarbamate and N-(2-phenylethyl)-N-(4-chlorobenzyl)dithiocarbamate)

    Science.gov (United States)

    Sathiyaraj, E.; Selvaganapathi, P.; Thirumaran, S.; Ciattini, Samuele

    2016-09-01

    Bis(N-(2-phenylethyl)-N-substituted benzyldithiocarbamato-S,S‧)nickel(II) (1-6) and (N-(2-phenylethyl)-N-substituted benzyldithiocarbamato-S,S‧)(thiocyanato-N) (triphenylphosphine)nickel(II) (7-12) [substituted benzyl = 2HO-C6H4-CH2- (1,7), 3HO-C6H4-CH2- (2,8), 4HO-C6H4-CH2- (3,9), 4CH3O-C6H4-CH2- (4,10), 4F-C6H4-CH2- (5,11), 4Cl-C6H4-CH2- (6,12)] complexes have been synthesized and characterized by elemental analysis, IR, UV-Vis and NMR (1H and 13C) spectroscopy. In the case of heteroleptic complexes 7-12, the shift in vC-N values to higher wavenumber and the NCS2 carbon signals are shifted to downfield compared to the homoleptic complexes indicating the increasing strength of thioureide vC-N bond due to the presence of π-accepting triphenylphosphine ligand in heteroleptic complexes. Electronic spectral studies on all the complexes (1-12) suggest square planar geometry around the nickel(II). Structures of 10 and 12 have been elucidated by X-ray crystallography. The dithiocarbamate anions in 10 and 12 chelate to the nickel atom. Both the structures reveal C-H⋯Ni intramolecular anagostic interaction. C-H⋯π (chelate) is observed in complexes 10. Supramolecular frame works are stabilised by C-H⋯S, C-H⋯π and C-H⋯Cl non-covalent interaction. The molecular geometry, HOMO-LUMO in the ground state and MEP have been calculated for 10 and 12 using Hartree-Fock (HF) method with LANL2DZ basic set. Molecular electrostatic potential diagram of complexes 10 and 12 support the partial double bond character of C-N (thioureide) bond in dithiocarbamate ligands.

  12. Importance of fracture mechanics for materials development. Safety analysis of steel structures using fracture mechanics methods. Bedeutung der Bruchmechanik fuer die Werkstoffentwicklung. Sicherheitsanalyse von Bauwerken aus Stahl mit Hilfe bruchmechanischer Methoden

    Energy Technology Data Exchange (ETDEWEB)

    Dahl, W. (Technische Hochschule Aachen (Germany, F.R.). Lehrstuhl und Inst. fuer Eisenhuettenkunde)

    1991-01-01

    Following a brief description of the safety analysis procedure, the article deals with the fracture mechanics behaviour of cracked components and material test pieces. A component is assessed by comparing the loads (stress applied, maximum stress intensity, etc.) and the material characteristics (proof stress, fracture toughness, critical J-integral, etc.). Quantifying the toughness of materials is a particularly important aspect. It can be further improved by material development (increased purity, less segregation, finer grain). Generally valid equations cannot be expected but reliable estimates of the relationships are possible. (orig.).

  13. Role of storage technologies to integrate high shares of renewable electricity generation into the electricity system of Germany. Simulation and optimization; Rolle und Bedeutung der Stromspeicher bei hohen Anteilen erneuerbarer Energien in Deutschland. Speichersimulation und Betriebsoptimierung

    Energy Technology Data Exchange (ETDEWEB)

    Hartmann, Niklas

    2013-06-13

    The share of renewable electricity generation of gross electricity consumption in Germany increased from 6.8 % to about 20 % during the years of 2000 and 2011. This share will increase even more in the future. The greater part of the renewable electricity generation is characterized by significant fluctuations, which can only be planned to a limited extent. Hence, the electricity system in Germany faces the challenge to integrate an increasing amount of fluctuating renewable electricity generation. Additionally the system stability needs to be ensured, despite a decreasing capacity in conventional power plants. One option to support the integration of large amounts of renewable electricity generation and to enhance system stability is the deployment of storage technologies. The aim of this research was to analyze the role of storage technologies to integrate high shares of renewable electricity generation into the electricity system of Germany. To achieve this aim, adiabatic compressed air energy storage, diabatic compressed air energy storage and mobile battery storage systems were simulated and compared with a pumped hydro storage as the reference storage system. Key characteristics of these storage systems were modeled within a fundamental stochastic unit commitment model of the German power markets (Joint-Market-Model) in order to analyze the effect of the implementation of these storage systems on the overall cost of the electricity system. Additionally, the operation of the storages in an electricity system with high shares of renewable energy was evaluated. The results show that the integration of large shares of renewable electricity generation into the grid can only be achieved with a substantial implementation of storage systems. To integrate 50 % of renewable energy, a storage power of 27 GW and storage capacity of 245 GWh is needed. For a renewable energy share of 80 %, a storage power of 78 GW and a storage capacity of 6.3 TWh are necessary. A 100 % renewable energy share requires a storage power of 139 GW and a storage capacity of 83 TWh. This also requires a significant capital expenditure. One option to reduce the overall system costs without compromising the system stability is to allow ''curtailment'' of wind and solar power. Curtailment is hereby only used, if it leads to lower operating costs of the system. For 50 % share of renewable energy the storage power can be reduced from 27 GW to almost 11 GW at constant storage capacity. The required storage capacity is reduced from 6.3 TWh to 5.4 TWh and the storage power from 78 GW to 66 GW for a share of 80 % of renewable energy. For a share of 100 % of renewable energy, the requirement of storage capacity is reduced from 83 TWh to 57 TWh and of storage power from 139 GW to 106 GW. In all assessments, where curtailment is allowed, the system costs are reduced. With this procedure only a minor share of renewable electricity generation (<1 %) is hereby not integrated into the grid. Furthermore, in this research the effects of different charging strategies of electric vehicles are analyzed. An uncontrolled charging, where the electric vehicles are charged at the instant they are connected to the grid is compared with a controlled charging (Vehicle-to-grid, V2G), where the time of charging can be delayed due to economic reasons until the starting time of the next trip. However, the controlled charging strategy of electric vehicles was found to have very little positive effect on the system costs. In a year with low wind and solar supply (reduced wind and solar supply by 15 %), the system stability is not given for a share of renewable electricity generation of 80 % and 100 %. To ensure the system stability for very high shares of renewable electricity generation, the power plant portfolio needs to be determined based on a load curve with yearly low wind and solar supply.

  14. Präzisionsmessungen an Myondriftkammern für den CMS-Detektor und die Bedeutung des Myonsystems für die Higgs-Suche am LHC

    CERN Document Server

    Hermann, Sven

    2004-01-01

    This thesis deals with preparations for the experiment CMS (Compact Muon Solenoid) of the LHC (Large Hadron Collider) planned at CERN in Geneva (Switzerland). The construction of the muon system, especially of the drift chambers in the barrel detector constructed with participation of the Aachen group, is explained. In the first part of the thesis the results from a Monte-Carlo-study for a decay channel interesting for the search for the Higgs boson at CMS is presented. In this channel the Higgs finally decays into four muons. The second part describes the running production of the drift chambers as well as results of tests developed and implemented for purposes of quality control. The LHC will accelerate protons to a center of mass energy of 14 TeV, aspiring to a luminosity of L = 10^34 cm^-2s^-1, allowing for the production of a sufficient number of such processes as rare as the production of Higgs bosons, which were predicted, but not yet proven. The Higgs bosons, created mainly by gluon gluon fusion in pr...

  15. Gaby Temme, Christine Künzel (Hg.: Hat Strafrecht ein Geschlecht? Zur Deutung und Bedeutung der Kategorie Geschlecht in strafrechtlichen Diskursen vom 18. Jahrhundert bis heute. Bielefeld: transcript Verlag 2010.

    Directory of Open Access Journals (Sweden)

    Monika Frommel

    2011-03-01

    Full Text Available Das moderne Strafrecht sollte informelle Geschlechternormen neutralisieren. Dies gelingt auch, kann aber bei der Strafzumessung unterlaufen werden. Wie der vorliegende Band in historisch ausgerichteten Einzelstudien zeigt, war das Strafrecht nie so objektivierend, wie es die Reformen seit den 1970er Jahren anstreben. Am Beispiel der Kindsmörderin wird nachgewiesen, dass der Verstoß gegen Geschlechtertugenden auch heute noch jederzeit mit harten Strafen sanktioniert werden kann.Modern criminal law should neutralize informal gender norms. This is by and large successful; however, it can be circumvented in the assessment of penalty. As shown by the historically orientated individual articles of this anthology, criminal law has never been as objectifying as the reforms since the 1970s are aspiring. Using the example of the female infanticide, the anthology proves that the violation of gender virtues can at all times still be sanctioned with severe penalties.

  16. Radioimmunoassay of serum myoglobin and its signifance for diagnosis and therapy of musculoskeletal diseases. Der radioimmunologische Myoglobinnachweis im Serum und seine Bedeutung bei der Diagnostik und Therapie von Skelettmuskelerkrankungen

    Energy Technology Data Exchange (ETDEWEB)

    Kiessling, W.R.

    1982-01-01

    A commercial test kit for radioimmunologic proof of myoglobin in serum was tested with regard to its specificty, sensitivity, precision, reproducibility, recovery and use in the diagnosis and therapy of musculoskeletal diseases. In the serum of 164 healthy control persons (age: 2-79 years) the individual myoglobin concentrations ranged from 4 to 60 ng/ml. Among 300 patients with muscular diseases extreme myoglobinaemia in acute rhabdomyolysis, polymyositis and dermatomyositis and different progressive muscular dystrophies could be detected. Slightly increased myoglobin concentrations could be proved in a number of patient with amyotrophic lateral sklerosis, neural muscular atrophy and in all cases of spinal muscular atrophy of the Kugelberg-Welander type. Confirmed DMD patients exhibited in about 80% of the cases hypermyoglobinaemia, and about 11% of 43 possible DMD patients showed an increase in myoglobin. Taking acute rhabdomyolysis and myositis as an example, it was found that myoglobin correlates well with the clinical course of these diseases and permits safe inferences as to the efficiency of the therapy chosen.

  17. Wissenschaftliche Netzwerke und klassifikatorische Bedeutung im Psychiatrischen Handbuch (Traité de Psychiatrie der Medizinisch-Chirurgischen Enzyklopädie (1947-1977 am Beispiel des Begriffes der Psychose

    Directory of Open Access Journals (Sweden)

    Emmanuel Delille

    2009-12-01

    Full Text Available Der deutsche Ausdruck ‘Psychose’ (Carl Friedrich Canstatt, 1841 ist der wissenschaftliche Begriff, der sich zur Bezeichnung von bestimmten Geisteskrankheiten durchgesetzt hat. Als Ausgangsperspektive für die Untersuchung dient dabei die Geschichte der wissenschaftlichen Soziabilitäten. Der Zeitraum (1947-1977 wurde entsprechend der Tätigkeit des französischen Psychiaters Henri Ey im Rahmen der Gruppe „l’Evolution Psychiatrique“ (die Psychiatrische Entwicklung abgesteckt. Ich untersuche in ...

  18. The central importance of the EU emission trading scheme for achievement of the German climate protection target of 40% until 2020; Die zentrale Bedeutung des EU-Emissionshandels zur Erreichung des deutschen Klimaziels in Hoehe von 40 % bis 2020

    Energy Technology Data Exchange (ETDEWEB)

    Hermann, Hauke; Cludius, Johanna

    2014-02-15

    Both Germany and the European Union have set themselves targets for the reduction of greenhouse gas (GHG) emissions. The EU was the forerunner in 2008 when it adopted the Climate and Energy package and set a target of reducing GHG emissions by 20 % by 2020 compared to 1990. Two years later, Germany adopted a range of national GHG targets in the context of the German government's Energy Concept. This includes a 40% emissions reduction target to be met by 2020. One of the main instruments for achieving GHG emissions reduction targets is the EU Emissions Trading Scheme (EU ETS), which covers all large industrial and combustion installations in Europe. According to the agreement made in 2008 (Climate and Energy Package), the effort to achieve the EU's 20 % reduction target by 2020 was split between the ETS sector (2/3 of the reduction effort, representing a 21 % reduction in GHG emissions for installations covered under the ETS compared to 2005) and the non-ETS sector (1/3 of the reduction effort, representing a 10 % reduction compared to 2005). Logically, GHG emissions reductions occurring in German ETS installations count both towards the EU and the national target. This research project has been commissioned to analyse whether the ETS in its cur-rent design can contribute its fair share in efforts to meet the national emissions reduc-tion target. This question is particularly relevant in light of the following considerations: - The new German Coalition Agreement, signed in December 2013, reiterated the national target of a 40 % reduction of GHG emissions by 2020 compared to 1990 levels. - At the same time, the new Coalition Agreement stated that changes to the ETS are only to be considered if the EU GHG emissions reduction target will not be met. - There is a surplus of CO2 allowances on the ETS market, which undermines the credibility of the instrument as well as the integrity of the emissions reduction tar-gets (both European and national). At the same time, the ETS has faced structurally low allowance prices from 2012 on-wards because of a massive supply of EU emission allowances (EUA) and external emission reduction credits, which exceeds the demand significantly. The surplus amounted to 1.8 billion EUAs at the end of the second trading period (2008-2012), will reach approx. 2 billion EUAs in 2013 and remain at up to 2 billion EUAs until the end of the third trading period (2013-2020). This structural surplus has significant implications for the fulfilment of European and national targets. The present research project concludes that the current design of the ETS is not ambitious enough to meet the national 40% target. Germany will also not be able to reach this target if the structural reform of the ETS is not improved considerably. Without this revision, there is a gap of 10.7 % to meeting the target based on 1990 levels, meaning that Germany would achieve an emissions reduction target of 29.3% instead of 40% in 2020. A combination of three factors is responsible for this gap: - surplus allowances being carried over from the second trading period (6.2 % compared to 1990); - a relatively unambitious reduction factor throughout the third trading phase compared to what should be achieved in the ETS sectors under the 40% national target (3 % compared to 1990); - a lack of ambition in the sectors not covered by the EU ETS compared to what should be achieved in the non-ETS sectors under the 40% national target (1.5 % compared to 1990). To meet the 40 % target in Germany, structural measures for reforming the EU ETS are necessary before 2020. Between 1.8 and 2.3 billion EU emission allowances (EUAs) have to be taken off the market in the long term (long-term set-aside) to remove current surpluses (1.8 billion EUAs) and to compensate for the expected imports of external emission reduction credits (0.5 billion CERs and ERUs) allowed to enter the market before 2020. Furthermore, the linear reduction factor needs to be tightened from the current 1.74 % to 2.9 % from 2014 onwards. The structural reform of the EU ETS that has been proposed by the EU Commission (creating a ''market stability reserve'' and increasing the linear reduction factor to 2.2 %, both only starting in 2021) is not sufficient for the national 40 % target to be met. There-fore, it is of crucial importance for the German government, if it takes its national com-mitments seriously, to call for a more ambitious reform of the EU ETS which results in larger emission reductions before 2020. In principle a solution on EU level is preferable to ensure the coherency and credibility of EU climate policy. Nevertheless, Germany should begin a discussion on national level about complementary measures (e.g. regulatory law) so that the national targets can still be met if it is not possible to realize an ambitious reform of the EU ETS on EU level.

  19. Sozialkapital und die Ko-Produktion von Gesundheit: die Bedeutung des organisationalen Handelns für die Qualität in der gesundheitlichen Versorgung am Beispiel der medizinischen Rehabilitation

    OpenAIRE

    Kockert, Svenja

    2014-01-01

    Die Dissertation dient einer theoretischen Ordnung und empirischen Prüfung von in der Literatur diskutierten Merkmalen und Faktoren leistungsfähiger Einrichtungen der gesundheitlichen Versorgung. Im Mittelpunkt der anwendungsorientierten Grundlagenforschung steht die Annahme, dass soziales Kapital in Organisationen als "Vertrauensressource" fungiert und dadurch der Selbstorganisation und gemeinschaftlichen Handlungen zwischen allen an einem Behandlungsprozess beteiligten Personen (Ko-Produzen...

  20. Bioaccumulation of heavy metals in the zebra mussel Dreissena polymorpha in the rivers Danube and Drau and its role as a bioindicator organism; Schwermetallbelastung von Dreissena polymorpha in Donau und Drau und ihre Bedeutung als Bioindikator

    Energy Technology Data Exchange (ETDEWEB)

    Luschuetzky, E.F. [Univ. Wien, Inst. fuer Zoologie, Abt. fuer Ultrastrukturforschung und Elektronenmikroskopie, Wien (Austria)

    2005-07-01

    Goal and scope. This study was undertaken to investigate the differences in heavy metal burden between the organisms and environmental compartments and to evaluate the role of Dreissena polymorpha as a bioindicator organism. Methods. The concentrations of zinc, copper, cadmium and lead in whole soft body and selected tissues of D. polymorpha at two river habitats in Austria were examined using atomic absorption spectroscopy (AAS). Concentrations in organisms were compared to those in sediment and water. Results and conclusion. Zebra mussels of the river Drau showed generally higher heavy metal concentrations as compared to mussels of the river Danube and contained elevated zinc and cadmium levels as compared to metal concentrations found in soft tissues of zebra mussels from uncontaminated sites in Germany and The Netherlands. The essential metals zinc and copper were mainly accumulated in gills, foot and byssal gland tissue of the mussel, in contrast to the non-essential metals cadmium and lead which were found predominantly in the midgut gland. The heavy metal concentrations in both, sediments and mussel tissue, were higher than in water samples. There was no correlation between the concentrations in water and in the organisms except for zinc. In contrast, correlations were found between concentrations in sediments and mussel soft tissue. Recommendation and perspective. Further investigations should include the examination of sediments and consider the mechanism of food uptake to assess the role of D. polymorpha as a bioindicator organism. (orig.)

  1. The role of nuclear power for economy and environment: an estimation of the cost of phasing out nuclear energy in Germany; Zur Bedeutung der Kernenergie fuer die Volkswirtschaft und die Umwelt - Zur Abschaetzung der Kosten eines Ausstiegs

    Energy Technology Data Exchange (ETDEWEB)

    Pfaffenberger, W. [Oldenburg Univ. (Germany). Inst. fuer Volkswirtschaftslehre (VWL); Gerdey, H.J. [Bremer Energie-Institut, Bremen (Germany)

    1999-02-08

    VDEW has asked Bremer Energie-Institut to evaluate the role of nuclear power in electricity generation in Germany. This article summarises the methods used in this study and presents the results. A scenario of phasing out nuclear energy within 5 years is compared with a scenario on the basis of a life time for nuclear power plants of 40 years (reference). A simulation model of power generation is used to derive the differences between the two scenarios regarding the cost of electricity production and CO{sub 2} emission. Also possible consequences for the employment in the economy are being analysed. The comparison of the two scenarios shows a difference in CO{sub 2} emission of 1.8 bill. t and about 88 bill. DM (current prices) in the next 30 years. (orig.) [Deutsch] Die Vereinigung Deutscher Elektrizitaetswerke - VDE - e.V., hat das Bremer Energie-Institut beauftragt, eine volkswirtschaftliche Bewertung des Beitrags der Kernenergie durchzufuehren. Die Verfasser erlaeutern die Studie und stellen das Ergebnis vor. (orig.)

  2. With regard to the significance of nuclear power for the economy and the environment; Zur Bedeutung der Kernenergie fuer die Volkswirtschaft und die Umwelt. Zur Abschaetzung der Kosten eines Ausstiegs

    Energy Technology Data Exchange (ETDEWEB)

    Gerdey, H.J. [Oldenburg Univ. (Germany). Inst. fuer Volkswirtschaftslehre (VWL); Pfaffenberger, W. [Oldenburg Univ. (Germany). Inst. fuer Volkswirtschaftslehre (VWL)]|[Bremer Energie-Institut, Bremen (Germany)

    1999-03-01

    The authors present an interesting comparative calculation: What (investment) costs, prices, emissions and employment figures are to be expected on the energy sector if the permission to operate nuclear power stations is sustained without time limit (scenario 1), or if all remaining nuclear power stations are shut-down by the year 2004 (scenario 2). These business economists come to the conclusion that in the case of shut-down of operation of nuclear power stations, the price for electric energy will increase on a short-term basis and the investment costs will initially rise significantly, but as from the year 2024 these relationships will reverse - the golden end of the early investments will then pay off. However, the authors estimate that the nominal additional costs for quick shut-down of nuclear power stations will amount to 87.6 billion DM. They estimate a loss of only 23 000 jobs. A problematic aspect of quick shutdown in above all the dramatically greater emission of CO{sub 2}; it will increase by 1850 million tons. According to the opinion of the authors, this figure is unavoidable - without corresponding technical innovation - and also not acceptable within the limits of responsibility. The prognosis is reserved with regard to technical innovation on the sector of fossil fuel power stations, because if nuclear power stations are shut-down quickly there will hardly be enough time for new technical developments. (orig.) [Deutsch] Die Autoren legen eine interessante Vergleichsrechnung vor: Welche (Investitions-)kosten, Preise, Emissionen, und Beschaeftigungszahlen sind im Energiebereich zu erwarten, wenn die Genehmigungsdauer fuer Kernkraftwerke unbefristet bestehen bleibt (Szenario 1) bzw. wenn alle verbleibenden Kraftwerke zum Jahr 2004 abgeschaltet werden (Szenario 2). Die Volkswirtschaftler kommen zu dem Ergebnis, dass bei der Umsetzung des Ausstiegsbeschlusses kurzfristig die Strompreise steigen werden und die Investitionskosten zunaechst deutlich ansteigen; ab dem Jahr 2024 kehrt sich dieses Verhaeltnis aber um - das goldene Ende der vorgezogenen Investitionen schlaegt dann zu Buche. Allerdings veranschlagen die Autoren die nominalen Mehrkosten bei einem schnellen Ausstieg mit 87,6 Mrd. DM. Den Verlust an Arbeitsplaetzen beziffern sie mit 23.000 Beschaeftigten. Problematisch ist bei einem schnellen Ausstieg vor allem der dramatisch hoehere Ausstoss an CO{sub 2}: Er liegt um 1850 Millionen Tonnen hoeher. Nach Ansicht der Autoren ist dieser Wert - ohne entsprechende technische Innovationen - nicht zu vermeiden und auch nicht zu verantworten. In Bezug auf technische Innovationen im Bereich der fossilen Kraftwerke bleibt die Prognose aber zurueckhaltend, da bei einem schnellen Ausstieg aus der Kernenergie kaum Zeit fuer technische Neuentwicklungen bleibe. (orig.)

  3. Solubility of nuclear reaction and corrosion products in the mercury spallation target. Significance for the operation and methods of calculation; Loeslichkeit von Kernreaktions- und Korrosionsprodukten im Quecksilber-Spallationstarget. Bedeutung fuer das Betriebsverhalten und Moeglichkeiten der Kalkulation

    Energy Technology Data Exchange (ETDEWEB)

    Eichler, B.; Dressler, R.

    1999-05-01

    The solubility of the transmutants and construction materials can influence the corrosion of the target vessel and the circuit components. In addition the solubility has an influence on the formation of solid depositions on the surfaces as well as on the segregation of mobile solid particles. As a first step calculations of the partial molar enthalpies of mixing at in infinite dilution were performed using the Miedema-Model. The bonding energies of metallic elements with mercury are present as periodic function in dependence on the atomic number. In a second step an extension was performed with the introduction of the latent enthalpies and entropies of transformation and fusion of the metallic elements. In case of formation of amalgams the integral molar formation enthalpies of the mercury-richest intermetallic compounds were considered. The calculated partial molar enthalpies of solution are discussed in comparison with literature data. For metals which co-exist in pure state with the saturated solution in liquid mercury the solubilities were calculated in the temperature range between 400 - 550 K. (author)

  4. The relevance of cytokines in the radiation-induced lung reaction. Experimental basis and clinical significance; Die Bedeutung von Zytokinen fuer die radiogene Lungenreaktion. Experimentelle Grundlagen und klinische Relevanz

    Energy Technology Data Exchange (ETDEWEB)

    Ruebe, C.E.; Ruebe, C. [Abt. fuer Strahlentherapie, Univ. des Saarlandes, Homburg/Saar (Germany); Rodemann, H.P. [Sektion fuer Strahlenbiologie und Molekulare Umweltforschung, Universitaetsklinik fuer Radioonkologie, Tuebingen (Germany)

    2004-09-01

    Methods: published data on radiation-induced cytokine expression from experimental and clinical studies are reviewed. Results and conclusion: the major pro-inflammatory cytokines in the radiation response of the lung include tumor necrosis factor-{alpha} (TNF-{alpha}), interleukin-1 (IL-1), and interleukin-6 (IL-6). Transforming growth factor-{beta} (TGF-{beta}) appears to be of particular importance in the development of lung fibrosis. First approaches with radioprotective agents and gene therapy to modify radiation-induced cytokine expression have been investigated for prevention of late effects of irradiation lung damage in animal experiments. Preliminary data of clinical studies suggest that elevated plasma TGF-{beta}-levels during radiotherapy may predict the development of symptomatic radiation pneumonitis. The biological impacts of endogenous radiation-induced cytokine production by tumor cells in respect of tumor behavior, potential damage to normal tissue, and clinical status of the host still need to be determined more precisely. (orig.)

  5. Clinical importance of CT-assisted sympathicolysis in primary, focal plantar and palmar hyperhidrosis; Klinische Bedeutung der CT-gestuetzten Sympathikolyse bei der primaeren, fokalen Hyperhidrosis plantaris et palmaris

    Energy Technology Data Exchange (ETDEWEB)

    Scheer, F.; Kamusella, P.; Wissgott, C.; Andresen, R. [Westkuestenklinikum Heide, Akademisches Lehrkrankenhaus der Universitaeten Kiel, Luebeck und Hamburg (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie/Neuroradiologie; Wins, A. [BAD, Zentrum Rostock (Germany); Wiggermann, P. [Universitaetsklinik Regensburg (Germany). Inst. fuer Roentgendiagnostik

    2012-07-15

    Purpose: The objective of this study was to evaluate the benefit of thoracic and lumbar computed tomographic-assisted sympathicolysis (CTSy) in patients with primary, focal hyperhidrosis. Materials and Methods: Thoracic and/or lumbar CTSy was conducted on 101 patients (average age 37.5 {+-} 15.5 years) with primary, focal hyperhidrosis of the hands and/or feet, who experienced persistent symptoms after all conservative treatment options had been exhausted. The patients were divided into groups with palmar, palmoplantar and plantar hyperhidrosis. The patients evaluated the severity of their symptoms prior to the intervention and 2 days, 6 months and 12 months after the intervention using a Dermatology Quality of Life Index (DLQI) and side effects. Results: The performed interventions led to a statistically significant decrease in the preinterventional severity of symptoms after the intervention (2 days), and 6 and 12 months after CTSy in the palmar, palmoplantar and plantar (p < 0.01) group. The technical success rate of CTSy was 100 %. No major complications occurred. Patients reported compensatory perspiration over the course of treatment, neuralgia and paraesthesia as side effects. The differentiated assessment of the strength of perspiration of the hands and feet showed statistically significant differences between the foot and hand region, whereby the decrease in sweat secretion of the feet was more significant and more lasting (p < 0.02). Conclusion: After conservative measures have been exhausted, CT-assisted sympathicolysis represents a therapeutic option with minimal side effects for patients with primary, focal hyperhidrosis. (orig.)

  6. Field strength in MR imaging of multiple sclerosis: A comparison of 0. 5 and 1. 5 T. Bedeutung der Magnetfeldstaerke in der MR-Diagnostik der multiplen Sklerose: Ein Vergleich von 0,5 und 1,5 T

    Energy Technology Data Exchange (ETDEWEB)

    Schima, W. (Universitaetsklinik fuer Radiodiagnostik und MR-Institut der Medizinischen Fakultaet, Vienna (Austria)); Wimberger, D. (Universitaetsklinik fuer Radiodiagnostik und MR-Institut der Medizinischen Fakultaet, Vienna (Austria)); Schneider, B. (Institut fuer Medizinische Statistik, Univ. Vienna (Austria)); Stiglbauer, R. (Universitaetsklinik fuer Radiodiagnostik und MR-Institut der Medizinischen Fakultaet, Vienna (Austria)); Asenbaum, S. (Universitaetsklinik fuer Neurologie, Vienna (Austria)); Imhof, H. (Universitaetsklinik fuer Radiodiagnostik und MR-Institut der Medizinischen Fakultaet, Vienna (Austria))

    1993-04-01

    The value of magnetic resonance (MR) to establish the diagnosis of multiple sclerosis (MS) is well known. This study was undertaken to compare MR imaging of the brain of MS patients at high (1.5 T) and mid (0.5 T) field strength. 25 patients with MS underwent two consecutive MR studies within one hour, each consisting of axial proton density and T[sub 2]-weighted spin-echo images. Lesions in the supratentorial white matter and corpus callosum and those in the brain stem and cerebellum were separately counted. At 1.5 T significantly more lesions were seen than at 0.5 T (p<0.05). Although T[sub 2]-weighted images at 1.5 T added significant information compared to images obtained at 0.5 T, in none of our 25 patients the diagnosis was missed at 0.5 T. However, at 1.5 T dissemination in space was better demonstrated, suggesting MR scanning with high field-units to be favourable in patients with clinically suspected MS. (orig.)

  7. S3 Guideline. Diagnosis and treatment of colorectal carcinoma. Relevance for radiologic imaging and interventions; Aktualisierte S3-Leitlinie zur Diagnostik und Therapie des kolorektalen Karzinoms. Bedeutung fuer die radiologische Diagnostik und Intervention

    Energy Technology Data Exchange (ETDEWEB)

    Vogl, T.J.; Fischer, S. [Universitaetsklinikum Frankfurt (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie; Schmiegel, W.; Pox, C. [Bochum Univ. (Germany). Medizinische Universitaetsklinik; Pereira, P.L. [SLK Kliniken, Heilbronn (Germany). Klinik fuer Radiologie, Minimal-Invasive Therapien und Nuklearmedizin; Brambs, H.J. [Universitaetsklinikum Ulm (Germany). Klinik fuer Diagnostische und Interventionelle Radiologie; Lux, P. [Universitaetsklinikum Erlangen (Germany). Chirurgische Klinik

    2013-08-15

    The new German S3 guideline 'Colorectal Carcinoma' was created as part of the German Guideline Program in Oncology of the Association of the Scientific Medical Societies in Germany, the German Cancer Society and the German Cancer Aid under the auspices of the German Society for Digestive and Metabolic Diseases and replaces the guideline from 2008. With its evidence-based treatment recommendations, the guideline contains numerous updates and detailed definitions regarding the diagnosis and treatment of colon and rectal cancer. In particular, consensus-based recommendations regarding early detection, preoperative diagnostic method selection, and the use of interventional radiological treatment methods are detailed. The guideline also includes quality indicators so that standardized quality assurance methods can be used to optimize patient-related processes. The present article discusses the significance of the current recommendations for radiological diagnosis and treatment and is intended to enhance the quality of patient information and care by increasing distribution. (orig.)

  8. Chimäre Mensch?: die Bedeutung der menschlichen Natur in Zeiten der Xenotransplantation = Chimeric human?: the importance of human nature in times of xenotransplantation = Quimera humana?: importância da natureza humana em tempos de xenotransplantes

    Directory of Open Access Journals (Sweden)

    Vieth, Andreas

    2013-01-01

    Full Text Available O artigo reexamina a questão dos xenotransplantes (transplantes de órgãos entre diferentes espécies, tecendo várias observações sobre as práticas de xenotransplantes com o intuito de determinar com precisão o que se entende por “xenotransplante” (XTP e de esclarecer em que medida um transplante de animais no organismo humano pode ser denominado uma “quimera”. Em seguida, os aspectos problemáticos do XTP, desde uma perspectiva ética, embora não sejam abordados no artigo, são nomeados em sua relevância teórica para o conceito de justificação, num sentido ético-normativo. Esclarecimentos conceituais e terminológicos preliminares são oferecidos pelos Autores a fim de deixar claro o que se entende, afinal, por “natureza”, tanto num sentido restrito quanto em sua relevância para as discussões éticas. O atual debate em torno de questões normativas e naturalistas da natureza e da ética é revisado em vários aspectos, culminando numa alternativa sistemática a ser desenvolvida e proposta

  9. Die Bedeutung von Husserls Logischen Untersuchungen für die Realistische Phänomenologie - Und die Kritik Realistischer Phänomenologen an einigen Husserl’schen Thesen

    Directory of Open Access Journals (Sweden)

    Josef Seifert

    2015-08-01

    Full Text Available Dieser Essay bietet eine kritische Beurteilung der Rolle der Logischen Untersuchungen (LU Husserls als Grundlage für eine phänomenologische und objektivistische Wiederentdeckung und Weiterentwicklung der Philosophie als solcher, und damit für den “phänomenologischen Realismus.” Letzterer versteht den Ruf “Zurück zu den Sachen selbst!” als Ur-Grundsatz der phänomenologischen und jeder authentischen Philosophie als solcher. Husserls Unterscheidungen zwischen notwendigen Wesenssachverhalten, wie daß ein X notwendigerweise y ist, gegenüber subjektiven „Gesetzen des Denkens, daß X notwendigerweise die Eigenschaft y habe” (und allgemein zwischen psychologischen und logischen Gesetzen bilden ein Fundament des philosophischen Objektivismus und Realismus. Sie werden zu Instrumenten von Husserls brillanter Widerlegung jeder Form von psychologistischer und subjektivistischer Interpretation logischer Gesetze und Prinzipien. Dazu kommen seine wichtigen Unterscheidungen zwischen sprachlichem “Ausdruck” und idealer logischer “Bedeutung” sowie der letzteren von den schwankenden Wortbedeutungen, Zeichen, Objekt und Sachverhalt, sowie seine Entdeckung der “reinen Grammatik” und vieles andere mehr. All diese bahnbrechenden Husserl’schen Beiträge in den LU führten in der Münchener-Göttinger Schule zu einer Grundlegung einer objektivistischen Logik und Phänomenologie, welche Deutungen logischer Gesetze wie des Satzes vom Widerspruch, so als wären diese grundlegenden logischen Gesetze nichts als subjektive psychologische Denkgesetze, ad absurdum führt. Die LU verteidigt einen strengen Objektivismus und die Absolutheit der Wahrheit. Das Werk zeigt die Widersinnigkeit der Idee einer “relativen Wahrheit” auf und verteidigt mit Nachdruck die Evidenz der philosophischen Einsicht als “unmittelbarer Erfahrung der Wahrheit”, die jede Form von Skepsis überwindet. Husserls - später aufgegebene - Entdeckung einer Erfahrung, durch die wir in sich selber notwendige apriorische Sachverhalte in einer, für alle denkenden Wesen, inklusive Gottes, gültigen und vor allem in sich wahren kategorialen Anschauung erkennen, bildete einen Durchbruch zu den Dingen an sich. Es ist der Zugang zu den Dingen an sich, den viele Philosophen seit Kant verloren glaubten. Husserl identifiziert diese notwendigen logischen Gesetze, mit denen sich die reine Wissenschaft der Logik beschäftigt, als entscheidende Grundlage allen Denkens und aller Wahrheit. Allein der Zugriff auf zeitlose, ideale Gesetze bietet eine rationale Grundlage, und sichert die Würde der Logik. Trotz dieser gigantischen Errungenschaften fordern eine beträchtliche Anzahl von Irrtümern in den LU und vor allem in späteren Werken Husserls seit 1905 (1913 eine Widerlegung, ohne die die LU ihre Rolle als Grundlage für den phänomenologischen Realismus nicht erfüllen kann. Husserls Einsicht, dass keine Erkenntnis möglich ist, in welcher wir Gegenstände erkennen, ohne daß diese intentionale Gegenstände unserer je eigenen Akte wären, muß von einer anderen widersprüchlichen und falschen Meinung Husserls scharf unterschieden werden. Nach dieser Auffassung könnte das Subjekt von nichts wissen, daß es mehr ist als nur ein rein intentionaler Gegenstand des Bewußtseins, was weder wahr ist noch aus der erwähnten Erkenntnis folgt. Diese Verwirrung ist vielleicht der wesentlichste Grund für Husserls Verlassen des philosophischen Realismus gewesen und ist Gegenstand unserer Kritik. Husserls Behauptung einer wirkursächlichen Determination aller wirklichen Seienden ist ein zweiter Grund für seine transzendentale Wende: Sie führt zu der irrigen Annahme, dass eine reale individuelle Person vollkommen unfähig wäre, ihre eigene kausal determinierte Subjektivität zu transzendieren und jene Wesenheiten und Wahrheiten zu erreichen, die völlig unabhängig vom Subjekt sind. Um daher die von Husserl verteidigte apriorische Erkenntnis zu begründen, müßte man ein transzendentales Ego annehmen. Ein drittes Motiv für Husserls Aufgeben einer realistischen Phänomenologie ist seine Annahme, die Wesensnotwendigkeiten gälten nur für ideale Objekte und Wesenheiten wie Zahlen und geometrische Figuren und nicht für in sich reale Wesen, welche die ausschließliche Domäne der empirischen Wissenschaften wären. Daher würde Realismus Empirismus einschließen, den Husserl zu Recht ablehnt. Der vorliegende Aufsatz argumentiert, daß Husserls Ziel der Erkenntnis notwendiger apriorischer Wahrheiten und eine Überwindung jeder subjektivistischen Erklärung ausschließlich durch Unterscheidungen zwischen drei Arten von Wesenheiten erreicht werden kann: a notwendigen, b morphisch-kontingenten doch sinnvollen, die nur für vielfältiges empirisches Wissen offen sind, und c rein zufällige, die nur durch Beobachtung bloßer Fakten festgestellt, nicht verstanden werden können. Während Husserl auf Grund seiner Unterscheidung zwischen abhängigen und unabhängigen Teilen die Entdeckung des Phänomens der notwendigen Wesenheiten zugeschrieben werden kann, zeigt Husserls Ansicht, daß das Wesensnotwendige durch eine bloße Epoché realer Existenz erreichbar sei, daß er die Unterscheidung notwendiger von anderen Wesenheiten nicht wirklich vollzogen hat. Die Begründung der realistischen Phänomenologie verlangt jedoch auch die radikale Überwindung von Husserls und Heideggers Identifizierung der Wirklichkeit mit der Zeitlichkeit, sowie der These, daß alle zeitlichen Ereignisse rein wirkursächlich durch vorhergehende Ursachen erklärt werden können. Diese Thesen würden den Todesstoß für jede Form des Realismus darstellen. Denn wenn unser Erkennen durch zeitlich vorhergehende Wirkursachen bestimmt wäre, würde dessen Inhalt weder durch deren wirklichen Gegenstand noch durch Wesensgesetze bestimmt werden, die in sich selbst sind, was sie sind. Vielmehr würde alles „Wissen” sozusagen „nur von hinten” und „extrinsisch” durch Kausalketten, die von der materiellen Welt oder einem dem Menschen transzendenten personalen Geist ausgingen, bestimmt werden. Etwa ein logisches Gesetz zu erkennen wäre dann rein von außen kausal bestimmt in einer Weise, die dem Wesen der Erkenntnis völlig widersprechen würde, anstatt vom erkannten Objekt. Folglich würde ein Kriterium der Erkenntnis niemals möglich sein, da Wirkursachen, die vom erkannten Objekt völlig verschieden sind, über den Inhalt des Wissens und Erkennens entscheiden würden. Aus diesem und anderen Gründen gelangte Husserl zur Überzeugung, daß das erkennende Subjekt und kognitive Evidenz nur durch transzendentale Egos, die sich von den individuellen realen Egos als „Stückchen der wirklichen Welt” unterschieden, erklärt werden könnten. Aus dieser Wende des späteren Husserl folgen letzten Endes ein radikaler Immanentismus, Subjektivismus, und am Ende auch Atheismus. Sie alle sind Folgen von Husserls Idee, daß wesensnotwendige Sachverhalte nicht nur selbst ursprünglich ideal und zeitlos sein müssen (was wahr ist, obwohl sie auch in kontingenten und reale Wesen verkörpert sind, sondern daß die Sphäre ihrer Anwendung nur ideale Bedeutungen und andere Gegenstände, die nicht der real existierenden Welt zugehören, sein können. Diese phänomenologisch vollständig unbegründete Verbannung des Reiches der Wirklichkeit in den Bereich der rein empirischen, zeitlich und deterministisch verursachten Welt ist nicht der unbedeutendste der Faktoren, die zu Husserls Ansicht geführt haben, daß das, was real ist, nur von empirischen Wissenschaften untersucht werden könne. Jeder phänomenologische Realismus muß in scharfem Gegensatz zu diesen Ansichten nicht nur die Herrschaft zeitloser Wesensgesetze über die wirkliche Welt, sondern auch anerkennen, daß reale Existenz selber ein wichtiges Objekt der Philosophie ist (nicht nur ideale Wesenheiten. Realistische Phänomenologie hat daher auch den „reinen philosophischen Essenzialismus” einiger objektivistischer Phänomenologen durch eine Reihe von entscheidenden Schritten zu überwinden: a In sich notwendige Wesenheiten und Wesensgesetze gelten für jede mögliche, und daher auch für die real existierende Welt. b Reale Existenz (der Actus Essendi, ist absolut nicht auf Essenz zu reduzieren und gültiger Gegenstand philosophischer Aufklärung. c Die konkrete Existenz meines realen Ich, und daher von wenigstens einem realen Seienden in der Welt finde ich in unzweifelhaftem Wissen im Cogito. d Sinneswahrnehmung und Erfahrungswissen von der realen Welt können rigoros gerechtfertigt werden. e Empathie und andere Formen der Erkenntnis erlauben uns, echtes Wissen über andere Personen zu erlangen. f Wir können die real existierende Welt, die real existierende Seele, die Person und ihre Unsterblichkeit rein philosophisch erkennen. g Das Wissen um das absolut real und unendlich vollkommene Wesen Gottes ist vollkommen rational gerechtfertigt durch die Gottesbeweise, insbesondere durch das ontologische Argument. All dies ist auch für den markanten Personalismus der realistischen Phänomenologie verantwortlich, einen Personalismus, den Husserl in mancher Hinsicht mitbegründet, in anderen jedoch vernachlässigt hat. Verbunden mit dem personalistischen Ansatz der realistischen Phänomenologie ist auch eine Neubegründung der Erkenntnis eines realen und lebendigen Gottes, der alle reine Vollkommenheiten in höchster Fülle besitzt, als gültiger Gegenstand der phänomenologischen Philosophie. Dies ist ebenfalls durch den Edmund Husserl der Logischen Untersuchungen, vor allem aber seitens des späteren Husserl ausgeschlossen. Husserls Identifizierung von wirklich mit zeitlich führt logisch zwingend zum Atheismus oder dem Agnostizismus einiger späterer Phänomenologen. Nur durch eine Überwindung der genannten falschen Annahmen Husserls sind die Bedingungen für einen phänomenologischen Realismus als klassische Philosophie auf der Grundlage der LU gegeben. Dies ermöglicht auch die Philosophie als strenge Wissenschaft, nicht nur der menschlichen Subjektivität, sondern auch des Seins an sich. Realistische Phänomenologie entpuppt sich somit als „Rettung” und Bewahrung der innersten Ziele, die Husserl in den LU formuliert hat. Die Aufgabe einer solchen phänomenologischen Philosophie ist nichts anderes als die Erfüllung des ursprünglichen Husserl'sche Rufes “Zurück zu den Sachen selbst”, die sich jetzt auch als eine Rückkehr zu den “Dingen an sich selbst”, die Husserl von der phänomenologischen Philosophie ausgeschlossen hat, erweist. Somit prägt den phänomenologischen Realismus die Erkenntnis der Transzendenz des Menschen in der Erkenntnis. Kurzum: Phänomenologie muß der Wahrheit treuer sein als Husserl: amicus Husserl – magis amica veritas! Abstract The paper presents a critical assessment of the role of Husserl’s Logical Investigations (LI as groundwork for a phenomenological and objectivist rediscovery and development of philosophy as such and thus for “phenomenological realism.” The latter understands the call “Back to Things themselves!” as the arch-principle of phenomenological and of authentic philosophy as such. Husserl’s distinctions between sign, linguistic “expression”, logical “meaning”, object and state of affairs, necessary essential laws that entail that X necessarily has to be y, and subjective laws of thinking that X has to be y, in LI become tools of Husserl’s brilliant refutation of every form of psychologism. Psychologistic philosophy interprets logical laws and principles, such as the principle of contradiction, as psychological laws. LI defends a strict objectivism and the absoluteness of truth. It shows the nonsensicalness of the idea of a “relative truth”; it defends forcefully the evidence of philosophical insight as “immediate experience of truth” that refutes every form of skepticism. Husserl’s - later abandoned - discovery of an experience through which real and essential being and intrinsically necessary a priori states of affairs are given in categorial intuitions, constituted a breakthrough to the thing in itself, to the noumenon that since Kant had been believed lost. Husserl’s path away from the confusions of purely linguistic laws with logical laws, his distinctions of the ideality of “units of meaning” from their linguistic expression and from the fluctuating word-meanings, as well as his discovery of “pure grammar” added to the very foundation of an objectivist logic and phenomenology. On this basis Husserl identifies those necessary logical laws which the pure science of logic deals with, and which concern an essential foundation of all thinking and all truth. Access to timeless, ideal laws alone provides a rational foundation, and secures the dignity, of logic. In spite of these gigantic achievements, however, a number of errors in LI and later works of Husserl call for a refutation, without which his LI cannot fulfill their role of groundwork for phenomenological realism. Husserl’s insight that no cognition is possible, in which the subject of knowing would not recognize whatever intentional object it comes to know exclusively through his own acts, has to be sharply distinguished from another contradictory and false opinion of Husserl. According to this view the subject could not know of anything that it is more than merely a purely intentional object of consciousness. This confusion may have been the major reason for Husserl’s abandoning philosophical realism and is subject of a refutation in this paper! Husserl’s asserting a (efficient causal determination of all real beings is a second reason for his transcendental turn: it leads to the mistaken assumption that a real and individual personal self is incapable of transcending his own causally determined subjectivity and of reaching essences and truths that are wholly independent from the subject.A third motive that prompted Husserl to abandon objectivist realist phenomenology is his assumption that essential necessities only apply to ideal objects and essences such as mathematical objects and not to real beings that would be the exclusive domain of empirical sciences. Hence realism would amount to empiricism, which Husserl rejects. The present paper argues that Husserl’s goal of discovering and explaining an objective a priori and overcoming every subjectivist explanation of a priori knowledge may solely be achieved through distinctions between three kinds of essences: necessary ones, morphic-contingent ones that are only open to empirical knowledge, and merely accidental ones. While Husserl, through his distinction between dependent and independent parts, can be credited with the discovery of the phenomenon of necessary essences and states of affairs, Husserl’s view that these can be reached by mere epoché has been refuted. The foundation of realist phenomenology, however, also demands the radical overcoming of the identification of reality with temporality found in both Husserl and Heidegger, as well as of the opinion of Husserl that all temporal being is causally determined by preceding causes, which would represent the deathblow for every form of realism. For in the case of its causal determination through temporally preceding (for instance, material causes, knowledge as regards its content would neither be determined by a real object nor by essential laws that exist in themselves. Rather, knowledge would be determined, as it were, “from the backside of things”, through causal chains supposedly belonging to the material world or to a real personal mind extrinsic to human acts. The act of knowing would then, however, be causally determined from the outside of its rational contact to its objects and therefore in a way that would completely contradict the essence of cognition. Consequently, a criterion of evident knowledge would never be possible, since efficient causes which are completely independent of the known object would decide over the content of knowing. For this reason, Husserl came to hold that the knowing subject and cognitive evidence can only be explained by a transcendental subject distinct from the individual real ego. Husserl’s later immanentism, subjectivism, and in the end also atheism follow from Husserl’s idea that essentially necessary states of affairs not only themselves have to be originally ideal and timeless (even though they are also embodied in contingent real beings, we must add, but can only refer to ideal meanings as the sphere of their application. This complete, and phenomenologically unfounded, banishing of the realm of the real into the realm of the empirical, temporal, and deterministically caused is not the least of the factors that led to Husserl’s opinion that that which is real can only be investigated by empirical sciences. Any phenomenological realism must overcome this view and recognize that also real existence is an important object of philosophy. Realist phenomenology has also overcome the “pure essentialism” of some objectivist phenomenologists through a series of decisive steps: a The recognition that the laws of absolutely necessary essences apply to every possible, but also to the real world. b Real existence, the actus essendi, is absolutely irreducible to essence. c The concrete existence of the real I, and hence of one real being in the world, is given in indubitable knowledge. d Sense perception as experiential knowledge of the real world can be rigorously justified. e Empathy and other forms of grasping allow us firm knowledge of existing other persons. f The knowledge of the real soul, of the person and her immortality, entail knowledge of the really existing world. g The knowledge of the absolutely real and infinitely perfect being, of God, is fully justified rationally, in particular through the ontological argument. All of this is connected to the distinct personalism of realist phenomenology, a personalism that Husserl in some respects co-founded, which, however, is decidedly neglected by him in many other ways. Linked to the personalistic approach of realist phenomenology is also a revolutionary new introduction of the real and living God who embodies all pure perfections as a valid object of phenomenological philosophy. This is likewise excluded by the Edmund Husserl of the Logical Investigations. Husserl’s identification of real with temporal being logically leads to the atheism and/or agnosticism of some later phenomenologists. Only when all these false presuppositions of Husserl have been overcome, are the conditions given for establishing phenomenological realism as classical philosophy on the foundation of LI. This allows also philosophy as a strict science not only of human subjectivity but also of being in itself. Realist phenomenology thus emerges as the “redemption” of the innermost goals that concerned Husserl in LI. The task of such a phenomenological philosophy is none other than the original Husserlian “Back to Things Themselves”, which now becomes a return to “Things in Themselves” that Husserl excluded from phenomenological philosophy, denying the fundamental datum of the transcendence of man in knowledge. In a word: phenomenology must be more faithful to truth than to Husserl: amicus Husserl – magis amica veritas!

  10. Fusion of CT and PET data: method and clinical relevance for planning laser-induced thermotherapy of liver metastases; Fusion von CT- und PET-Daten: Methode und klinische Bedeutung am Beispiel der Planung der laserinduzierten Thermotherapie von Lebermetastasen

    Energy Technology Data Exchange (ETDEWEB)

    Hosten, N.; Kreissig, R.; Puls, R.; Amthauer, H.; Beier, J.; Rohlfing, T.; Stroszczynski, C.; Herbel, A.; Lemke, A.J.; Felix, R. [Humboldt-Universitaet, Berlin (Germany). Strahlenklinik und Poliklinik

    2000-07-01

    Aim: Cathether-placement in liver metastases is difficult when the lesions are not visible on plain images. We evaluated the use of image fusion using CT and PET data, providing information on anatomy and liver lesions, respectively. Methods: Plain CT of the liver and whole body FDG-PET were performed in 28 patients with colorectal carcinoma in preparation for laser-induced thermotherapy. Fusions of image data and 2D-visualisation were performed and evaluated with regard to quality of the registration, number of detected lesions and influence of the procedure on laser-induced thermotherapy. Image fusion was performed using an algorithm which was developed by our group. Results: 84 focal liver lesions were visible on CT, 107 on PET images. This means that CT guided catheter placement would have to be performed 'blindly' in 23 lesions. In 6 patients previously unknown extra-hepatic tumor deposits were seen on PET images (local recurrence, 2 extrahepatic metastases, 2 second primaries). Conclusion: Hot spots from metastases, which are difficult to locate on PET images alone, may be identified on images generated by fusion of CT and PET data. These images facilitate an interventional approach to liver lesions which are not visible on plain CT. As PET allows for whole body screening, it helps identifying patients who would not profit from laser-induced thermotherapy. (orig.) [German] Ziel: Bei der CT-gesteuerten Punktion von Leberherden ist der fehlende Laesionsnachweis in der nativen CT oft hinderlich. Es wurde untersucht, ob die Bildfusion PET + CT weiterhilft. Methoden: Native Leber-CT und Ganzkoerper-FDG-PET wurden bei 28 Patienten mit kolorektalen Karzinomen durchgefuehrt, die zur LITT bei Lebermetastasen zugewiesen wurden. Die Datensaetze wurden fusioniert und hinsichtlich Qualitaet der Registrierung, Anzahl nachgewiesener Laesionen und Einfluss der fusionierten Bilder auf die Therapie ausgewertet. Ein selbstentwickelter Algorithmus wurde fuer die Fusion eingesetzt. Ergebnisse: Die native CT liess 84 Laesionen erkennen, die PET 107. Bei 1/3 der Patienten musste der Thermokatheter vor Beginn der Lasertherapie im MRT replaziert werden. Darueber hinaus zeigte die PET bei sechs Patienten nicht bekannte extrahepatische Tumormanifestationen (ein Lokalrezidiv, drei extrahepatische Metastasen, zwei Zweitkarzinome). Schlussfolgerung: Die Bildfusion erlaubt eine eindeutige anatomische Zuordnung der durch Lebermetastasen verursachten PET-Mehranreicherungen. Die fusionierten Bilder koennen die Punktion von Leberherden erleichtern, die in der nativen CT nicht sichtbar sind. Darueber hinaus hilft die fusionierte Ganzkoerper-PET solche fokalen Therapien zu vermeiden, die wegen extrahepatischer Manifestationen nicht indiziert sind. (orig.)

  11. Casino Capitalism and Its Legitimacy Impact on the Politico-administrative State in Macau Der Kasino-Kapitalismus in Macau und seine Bedeutung für die Legitimität des politisch-administrativen Systems

    Directory of Open Access Journals (Sweden)

    Sonny Lo

    2009-04-01

    Full Text Available Casino capitalism has its dialectical tendencies in Macau. On the one hand, it stimulates economic growth, provides employment, and strengthens the post-colonial state in Macau during the period of economic boom. On the other hand, casino capitalism can widen the income gap between the rich and the poor, generate addictive gambling, and de-legitimize the post-colonial state in Macau during the global and regional economic downturn. The weaknesses of the politico-administrative state in Macau, including the absence of institutional checks and balances, the frail civil society and the relatively docile mass media, have magnified the negative impacts of casino capitalism on Macau. In response to the negative ramifications, the Macau government has taken measures to be more interventionist, to enhance social welfare, and to prepare contingency plans that would tackle the sudden bankruptcy of any casinos. The central government in Beijing also displays contradictory considerations when it deals with Macau’s casino development, supporting the casino industry while simultaneously encouraging the Macau government to diversify its economy. Overall, casino capitalism not only has contradictory impacts on the Macau city-state but also reveals the inherent contradictions of Beijing’s policy toward the territory’s over-dependence on the casino economy. Der Kasino-Kapitalismus ruft in Macao widersprüchliche TEndenzen hervor: Einerseits stimuliert er das wirtschaftliche Wachstum und stärkt den post-kolonialen Staat in wirtschaftlichen Boomphasen, andererseits kann er aber auch dazu beitragen, dass sich die Einkommensunterschiede zwischen ärmeren und wohlhabenderen Schichten verstärken und damit in Krisenphasen zur Deligitimierung des postkolonialen Staates beitragen.

  12. Functional Analysis of Promoters in the Nisin Gene Cluster of Lactococcus lactis

    NARCIS (Netherlands)

    Ruyter, Pascalle G.G.A. de; Kuipers, Oscar P.; Beerthuyzen, Marke M.; Alen-Boerrigter, Ingrid van; Vos, Willem M. de

    1996-01-01

    The promoters in the nisin gene cluster nisABTCIPRKFEG of Lactococcus lactis were characterized by primer extension and transcriptional fusions to the Escherichia coli promoterless β-glucuronidase gene (gusA). Three promoters preceding the nisA, nisR, and nisF genes, which all give rise to gusA expr

  13. Autoregulation of Nisin Biosynthesis in Lactococcus lactis by Signal Transduction

    NARCIS (Netherlands)

    Kuipers, Oscar P.; Beerthuyzen, Marke M.; Ruyter, Pascalle G.G.A. de; Luesink, Evert J.; Vos, Willem M. de

    1995-01-01

    The post-translationally modified, antimicrobial peptide nisin is secreted by strains of Lactococcus lactis that contain the chromosomally located nisin biosynthetic gene cluster nisABTCIPRKFEG. When a 4-base pair deletion is introduced into the structural nisA gene (ΔnisA), transcription of ΔnisA

  14. Nosocomial Infections among Pediatric Patients with Neoplastic Diseases

    OpenAIRE

    Peninnah Oberdorfer; Natthida Pongwilairat; Washington, Charles H

    2009-01-01

    Background. Pediatric patients with neoplastic diseases are more likely to develop nosocomial infections (NIs). NIs may prolong their hospital stay, and increase morbidity and mortality. Objectives. The objectives of this study were to determine: (1) the incidence of NIs, (2) sites of NIs, (3) causal organisms, and (4) outcomes of NIs among pediatric patients with neoplastic diseases. Methods. This study was a prospective cohort study of pediatric patients with neoplastic diseases who were ad...

  15. AVALIAÇÃO DOS GÂNGLIOS REGIONAIS NO CARCINOMA EPIDERMÓIDE DO PÊNIS (CEP ATRAVÉS DE UM ÍNDICE DE RISCO

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    Cologna A. J.

    2001-01-01

    Full Text Available O objetivo desse estudo foi investigar a validade de um índice de risco (IR no prognóstico de metástases ganglionares no carcinoma epidermóide do pênis (CEP. Foram analisados 53 pacientes com CEP atendidos no Hospital das Clínicas da FMRP-USP, de janeiro de 1978 a dezembro de 1995. A idade variou de 32 a 97 anos. Os tumores foram graduados de acordo com a classificação de Broders e estadiados retrospectivamente (TNM 1999. O IR foi determinado pela soma de TeG (IR = T+G. A linfadenectomia inguinal bilateral (LD foi indicada naqueles que apresentaram gânglios suspeitos após a antibioticoterapia ou que vieram apresentar alterações durante o período de observação. Faleceram 17 pacientes; A LD foi realizada em 14 pacientes e os 39 restantes permaneceram em observação clínica, sendo que em 8 deles foi feito LD após tempo mediano de 9 meses. Dos pacientes com índice de risco 2 e 3 92% e 80% respectivamente não apresentavam metastase ganglionar, ao passo que a totalidade daqueles com IR=6 tinha gânglios comprometidos. A associação dos grupos 2 e 3, comparada ao conjunto 4, 5 e 6, mostrou percentual maior de comprometimento nestes últimos (p = 0,0046. Dos 36 pacientes inicialmente No, 27 apresentavam IR 2 ou 3, dos quais 5 evoluíram para N+ (19%; os 9 restantes eram IR > 4 e 3 também evoluíram para N+ (33%. Apesar da diferença, não houve significância estatística entre eles (p = 0,3837. Embora tenha ocorrido maior comprometimento naqueles com IR > 4, o índice de risco não foi capaz de identificar previamente pacientes que evoluíram para N+.

  16. MODIFICAÇÃO DA TÉCNICA DE ADERÊNCIA CIRÚRGICA DO PÊNIS À PAREDE ABDOMINAL VENTRAL E AVALIAÇÃO DO PÓS-OPERATÓRIO

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    Rogério Elias Rabelo

    2006-10-01

    Full Text Available Modificou-se a técnica de aderência cirúrgica do pênis à parede abdominal ventral a fim de se obter rufiões bovinos. Reduzindo o espaço morto com pontos de Wolf, a técnica resultou em compressão, estenose e ruptura parcial da uretra. As principais complicações observadas foram deiscência parcial e total da ferida cirúrgica, necrose tecidual, abcessos subcutâneos, presença de secreção purulenta, além de fibrose tecidual. Na tentativa de isolar e identificar os possíveis agentes microbianos envolvidos no processo colheram-se, por meio de zaragatoas embebidas em água peptonada a 0,1%, amostras das secreções purulentas, que fluíam das feridas. Isolaram-se e identificaramse os microrganismos Proteus mirabilis e Escherichia coli. O mesmo procedimento foi adotado no ambiente onde os animais foram operados e no local onde permaneceram após o ato cirúrgico, isolando-se e identificando-se o Bacillus spp, o Pseudomonas spp, o Escherichia coli e o Enterobacter spp. Não houve crescimento bacteriano nos fios de sutura pertencentes ao mesmo lote dos utilizados na cirurgia, descartando-se a hipótese de contaminação das feridas pelo uso de material ou instrumental cirúrgico mal esterilizado. As complicações observadas no pós-operatório foram atribuídas à ação irritativa da urina que, pela ruptura da uretra, acumulou-se e infiltrou-se nos tecidos subcutâneos em cicatrização, e à contaminação exógena. PALAVRAS-CHAVE: Rufiões bovinos, pós-operatório.

  17. 电沉积Ni-S、Ni-P-S合金析氢阴极的研究%Study on Electrodeposited Ni-S and Ni-P-S Alloy Cathodes for Hydrogen Evolution

    Institute of Scientific and Technical Information of China (English)

    马强; 巴俊洲; 蒋亚雄; 李军; 吴文宏

    2008-01-01

    在电沉积法制备Ni-S合金电极的基础上,向镀液中添加次亚磷酸钠制备了Ni-P-S合金电极.电化学测试结果表明,Ni-P-S和Ni-S合金电极的催化性能都要好于其它电极,Ni-P-S合金电极的性能随着次亚磷酸钠质量浓度的升高而降低.计算了电极的电极反应动力学参数(包括Tafel斜率b、交换电流密度ρ0和过电位η),解释了Ni-P-S合金电极和Ni-S合金电极在不同电流密度区活性不同的原因.恒电流电解表明,Ni-P-S合金电极具有较高的稳定性.电极的微现形貌用SEM进行表征,成份用能谱进行分析,通过X射线衍射分析电极的晶型结构.

  18. Nosocomial Infections among Pediatric Patients with Neoplastic Diseases

    Directory of Open Access Journals (Sweden)

    Peninnah Oberdorfer

    2009-01-01

    Full Text Available Background. Pediatric patients with neoplastic diseases are more likely to develop nosocomial infections (NIs. NIs may prolong their hospital stay, and increase morbidity and mortality. Objectives. The objectives of this study were to determine: (1 the incidence of NIs, (2 sites of NIs, (3 causal organisms, and (4 outcomes of NIs among pediatric patients with neoplastic diseases. Methods. This study was a prospective cohort study of pediatric patients with neoplastic diseases who were admitted to the Chiang Mai University Hospital, Thailand. Results. A total of 707 pediatric patients with neoplastic diseases were admitted. Forty-six episodes of NIs in 30 patients were reported (6.5 NIs/100 admission episodes and 7 NIs/1000 days of hospitalization. Patients with acute lymphoblastic leukemia had the highest number of NIs (41.3%. The most common causal organisms were gram-negative bacteria (47.1%. Patients who had undergone invasive procedures were more likely to develop NIs than those who had not (P<.05. The mortality rate of patients with NIs was 19.6%. Conclusion. Pediatric patients with neoplastic diseases are more likely to develop NIs after having undergone invasive procedures. Pediatricians should be aware of this and strictly follow infection control guidelines in order to reduce morbidity and mortality rates related to NIs.

  19. Nosocomial Infections among Pediatric Patients with Neoplastic Diseases.

    Science.gov (United States)

    Oberdorfer, Peninnah; Pongwilairat, Natthida; Washington, Charles H

    2009-01-01

    Background. Pediatric patients with neoplastic diseases are more likely to develop nosocomial infections (NIs). NIs may prolong their hospital stay, and increase morbidity and mortality. Objectives. The objectives of this study were to determine: (1) the incidence of NIs, (2) sites of NIs, (3) causal organisms, and (4) outcomes of NIs among pediatric patients with neoplastic diseases. Methods. This study was a prospective cohort study of pediatric patients with neoplastic diseases who were admitted to the Chiang Mai University Hospital, Thailand. Results. A total of 707 pediatric patients with neoplastic diseases were admitted. Forty-six episodes of NIs in 30 patients were reported (6.5 NIs/100 admission episodes and 7 NIs/1000 days of hospitalization). Patients with acute lymphoblastic leukemia had the highest number of NIs (41.3%). The most common causal organisms were gram-negative bacteria (47.1%). Patients who had undergone invasive procedures were more likely to develop NIs than those who had not (P < .05). The mortality rate of patients with NIs was 19.6%. Conclusion. Pediatric patients with neoplastic diseases are more likely to develop NIs after having undergone invasive procedures. Pediatricians should be aware of this and strictly follow infection control guidelines in order to reduce morbidity and mortality rates related to NIs.

  20. Role of commercial harbours and recreational marinas in the spread of non-indigenous fouling species.

    Science.gov (United States)

    Ferrario, Jasmine; Caronni, Sarah; Occhipinti-Ambrogi, Anna; Marchini, Agnese

    2017-09-01

    The role of commercial harbours as sink and source habitats for non-indigenous species (NIS) and the role of recreational boating for their secondary spread were investigated by analysing the fouling community of five Italian harbours and five marinas in the western Mediterranean Sea. It was first hypothesised that NIS assemblages in the recreational marinas were subsets of those occurring in commercial harbours. However, the data did not consistently support this hypothesis: the NIS pools of some marinas significantly diverged from harbours even belonging to the same coastal stretches, including NIS occurring only in marinas. This study confirms harbours as hotspots for marine NIS, but also reveals that numbers of NIS in some marinas is higher than expected, suggesting that recreational vessels effectively facilitate NIS spread. It is recommended that this vector of NIS introduction is taken into account in the future planning of sustainable development of maritime tourism in Europe.

  1. Psychobiological characteristics of dissociative identity disorder : A symptom provocation study

    NARCIS (Netherlands)

    Reinders, A. A. T. Simone; Nijenhuis, Ellert R. S.; Quak, Jacqueline; Korf, Jakob; Haaksma, Jaap; Paans, Anne M. J.; Willemsen, Antoon T. M.; den Boer, Johan A.

    2006-01-01

    Background: Dissociative identity disorder (DID) patients function as two or more identities or dissociative identity states (DIS), categorized as 'neutral identity states' (NIS) and 'traumatic identity states' (TIS). NIS inhibit access to traumatic memories thereby enabling daily life functioning.

  2. Psychobiological characteristics of dissociative identity disorder : A symptom provocation study

    NARCIS (Netherlands)

    Reinders, A. A. T. Simone; Nijenhuis, Ellert R. S.; Quak, Jacqueline; Korf, Jakob; Haaksma, Jaap; Paans, Anne M. J.; Willemsen, Antoon T. M.; den Boer, Johan A.

    2006-01-01

    Background: Dissociative identity disorder (DID) patients function as two or more identities or dissociative identity states (DIS), categorized as 'neutral identity states' (NIS) and 'traumatic identity states' (TIS). NIS inhibit access to traumatic memories thereby enabling daily life functioning.

  3. Active nature of primary amines during thermal decomposition of nickel dithiocarbamates to nickel sulfide nanoparticles

    NARCIS (Netherlands)

    Hollingsworth, Nathan; Roffey, , Anna; Islam, Husn-Ubayda; Mercy, Maxime; Roldan, Alberto; Bras, Wim; Wolthers, Mariëtte; Catlow, C. Richard A.; Sankar, Gopinathan; Hogarth, Graeme; de Leeuw, Nora H.

    2014-01-01

    Although [Ni(S2CNBu2i)(2)] is stable at high temperatures in a range of solvents, solvothermal decomposition occurs at 145 degrees C in oleylamine to give pure NiS nanoparticles, while in n-hexylamine at 120 degrees C a mixture of Ni3S4 (polydymite) and NiS results. A combined experimental and theor

  4. Dietary I(-) absorption: expression and regulation of the Na(+)/I(-) symporter in the intestine.

    Science.gov (United States)

    Nicola, Juan Pablo; Carrasco, Nancy; Masini-Repiso, Ana María

    2015-01-01

    Thyroid hormones are critical for the normal development, growth, and functional maturation of several tissues, including the central nervous system. Iodine is an essential constituent of the thyroid hormones, the only iodine-containing molecules in vertebrates. Dietary iodide (I(-)) absorption in the gastrointestinal tract is the first step in I(-) metabolism, as the diet is the only source of I(-) for land-dwelling vertebrates. The Na(+)/I(-) symporter (NIS), an integral plasma membrane glycoprotein located in the brush border of enterocytes, constitutes a central component of the I(-) absorption system in the small intestine. In this chapter, we review the most recent research on structure/function relations in NIS and the protein's I(-) transport mechanism and stoichiometry, with a special focus on the tissue distribution and hormonal regulation of NIS, as well as the role of NIS in mediating I(-) homeostasis. We further discuss recent findings concerning the autoregulatory effect of I(-) on I(-) metabolism in enterocytes: high intracellular I(-) concentrations in enterocytes decrease NIS-mediated uptake of I(-) through a complex array of posttranscriptional mechanisms, e.g., downregulation of NIS expression at the plasma membrane, increased NIS protein degradation, and reduction of NIS mRNA stability leading to decreased NIS mRNA levels. Since the molecular identification of NIS, great progress has been made not only in understanding the role of NIS in I(-) homeostasis but also in developing protocols for NIS-mediated imaging and treatment of various diseases.

  5. Nisin生物合成相关基因分析%Anylysis of the Genes Related to Nisin's Synthesization

    Institute of Scientific and Technical Information of China (English)

    姜延龙; 霍贵成

    2005-01-01

    Nisin是乳酸乳球菌某些菌株产生的一种对细菌芽孢和多种革兰氏阳性菌有较好杀伤作用的小肽,广泛用干食品加工、医疗保健等诸多领域.合成Nisin的基因位于染色体上一可接合型蔗糖转座子,由三个启动子nisA、nisR、nisF控制的nisA/ZBTCIPRKFEG构成,其中nisA因具有更强的启动强度,且表达诱导物和宿主菌均为食品级,方便、经济、安全,应用最为广泛.其他基因分别在Nisin合成、调控过程中起不同作用:自身保护性基因ninI、nisF、nisE、nisG的表达,使菌体获得对Nisin较好的耐受性;NisB和NisC与翻译后修饰有关;NisT可促进乳链菌肽前体转移至胞外;NisP则与nisin前体信号肽的切除有关.

  6. Effects of gene disruptions in the nisin gene cluster of Lactococcus lactis on nisin production and producer immunity

    NARCIS (Netherlands)

    Ra, Runar; Beerthuyzen, Marke M.; Vos, Willem M. de; Saris, Per E.J.; Kuipers, Oscar P.

    1999-01-01

    The lantibiotic nisin is produced by several strains of Lactococcus lactis subsp. lactis. The chromosomally located gene cluster nisABTCIPRKFEG is required for biosynthesis, development of immunity, and regulation of gene expression. In-frame deletions in the nisB and nisT genes, and disruption of

  7. Žodžio trum̃pas keleto tarminių sinonimų etimologija

    Directory of Open Access Journals (Sweden)

    Vincas Urbutis

    2001-01-01

    äsentanten der unerweiterten *bhei- Wurzel gehalten werden, vgl. lett. bdît „schieben, rücken, schiebend stoßen; stopfen" : bît „schieben". Auf diese Weise sind lit. dial. bìznas, bìzdras und bìskas wie auch ihr Synonym bìgas wahrscheinlich auf die gleiche Wur­zel zurückzuführen. Die angeführte Erklärung der Benennungen für „kurz" mit bizd- ist al­lerdings anfechtbar, denn das bizd- könnte eventuell auch zu der Familie von lit. bezdė́ti (= lett. bezdêt „furzen" gehören.3. Lit. dial, gruzìnis, -ė „kurz" hat z aus ž (zBedeutung „kahl, kurzhaarig, kurz geschnitten, gestutzt" gebraucht wird.

  8. Study on the Iodine 125 Uptake of H460 Lung Cancer Cell Line by Co-transfection with the Human Sodium/Iodide Symporter and the Human Thyroperoxidase

    Directory of Open Access Journals (Sweden)

    Wei LI

    2010-06-01

    Full Text Available Background and objective Lung cancer harms people’s health or even lives severely. Especially, the therapy of non-small cell lung cancer (NSCLC has not been obviously improved for many years. The aim of this study is to transfer the human sodium/iodide symporter (hNIS and the human thyroperoxidase (hTPO genes into H460 lung cancer cell line, and to study the uptake ability of iodide after co-transfected hTPO and hNIS gene in cell lines. Methods Through cloning, recombination, packaging and amplifying, the recombinant adenosine virus (AdTPO was constructed. Then the protein expression of AdTPO was tested by Western blot. After transfected hNIS gene into human lung cancer cell line H460 through liposome, stably expressing hNIS gene cell lines (hNIS-H460 selected by G418 antibiotics was determined as hNIS-H460 group. Using AdTPO, hTPO gene was transducted into hNIS-H460, as AdTPO-hNIS-H460 group. H460 cell without hNIS gene was applied as control group (H460. Then, we investigated the 125I uptake assay of the above cells. Results We were successful in co-transfecting hNIS and hTPO gene into human lung cell lines H460, and were obtained hNIS and hTPO gene lung cancer cell lines (hNIS-H460 and AdTPO-hNIS-H460. In AdTPO-hNIS-H460, hNIS-H460 and H460, the uptake ability of 125I was (59 637.67±1 281.13, (48 622.17±2 242.28 and (1 440.17±372.86 counts•min-1. The uptake ability of 125I was 41 fold higher in AdTPO-hNIS-H460 than in blank control H460 (P<0.01, and 34 fold higher in hNIS-460 than in blank control H460 (P<0.01, and 1.2 fold higher in AdTPO-hNIS-H460 than in hNIS-H460 (P<0.01. Conclusion The uptake ability of 125I could increase by co-transfected hNIS and hTPO genes into human lung cancer cell lines H460.

  9. Nuclear-plus-interference-scattering effect on the energy deposition of multi-MeV protons in a dense Be plasma

    Science.gov (United States)

    Wang, Zhigang; Fu, Zhenguo; He, Bin; Hu, Zehua; Zhang, Ping

    2016-09-01

    The nuclear plus interference scattering (NIS) effect on the stopping power of hot dense beryllium (Be) plasma for multi-MeV protons is theoretically investigated by using the generalized Brown-Preston-Singleton (BPS) model, in which a NIS term is taken into account. The analytical formula of the NIS term is detailedly derived. By using this formula, the density and temperature dependence of the NIS effect is numerically studied, and the results show that the NIS effect becomes more and more important with increasing the plasma temperature or density. Different from the cases of protons traveling through the deuterium-tritium plasmas, for a Be plasma, a prominent oscillation valley structure is observed in the NIS term when the proton's energy is close to Ep=7 MeV . Furthermore, the penetration distance is remarkably reduced when the NIS term is considered.

  10. National Innovation System And Culture A Cross-Country Analysis

    Directory of Open Access Journals (Sweden)

    Joseph Gogodze

    2015-08-01

    Full Text Available This study assesses the relationship between Hofstedes cultural dimensions and the constituents of a National Innovation System NIS. We consider an NIS as a special kind of intangible latent asset and identify its two constituents input and output capital. These are extracted through a modern NIS measurement model based on the Global Innovation Index. Using structural equation models we show that power distance and uncertainty avoidance and long-term orientation and indulgence vs. restraint act through the latent constructs PDUA and LTIV respectively. Moreover individualism IDV and NIS constituents are directly and negatively affected by PDUA. IDV and LTIV directly and positively affect the NIS constituents. Further the results show that masculinity vs. femininity significantly and negatively affects the NIS input constituent and significantly affects the NIS output constituent but its impact is negative for high-income countries and positive for non-high income countries.

  11. Nuclear-plus-interference-scattering effect on the energy deposition of multi-MeV protons in a dense Be plasma.

    Science.gov (United States)

    Wang, Zhigang; Fu, Zhenguo; He, Bin; Hu, Zehua; Zhang, Ping

    2016-09-01

    The nuclear plus interference scattering (NIS) effect on the stopping power of hot dense beryllium (Be) plasma for multi-MeV protons is theoretically investigated by using the generalized Brown-Preston-Singleton (BPS) model, in which a NIS term is taken into account. The analytical formula of the NIS term is detailedly derived. By using this formula, the density and temperature dependence of the NIS effect is numerically studied, and the results show that the NIS effect becomes more and more important with increasing the plasma temperature or density. Different from the cases of protons traveling through the deuterium-tritium plasmas, for a Be plasma, a prominent oscillation valley structure is observed in the NIS term when the proton's energy is close to E_{p}=7MeV. Furthermore, the penetration distance is remarkably reduced when the NIS term is considered.

  12. Internal radiotherapy of liver cancer with rat hepato-carcinoma-intestine-pancreas gene as a liver tumor-specific promoter

    Energy Technology Data Exchange (ETDEWEB)

    Herve, J.; Cunha, A. Sa; Liu, B.; Valogne, Y.; Longuet, M.; Bregerie, O.; Guettier, C.; Samuel, D.; Brechot, C.; Faivre, J. [Hop Paul Brousse, INSERM, Hepatobiliary Ctr, U785, F-94800 Villejuif (France); Herve, J.; Cunha, A. Sa; Liu, B.; Valogne, Y.; Longuet, M.; Bregerie, O.; Guettier, C.; Samuel, D.; Brechot, C.; Faivre, J. [Univ Paris Sud, Fac Med, F-94800 Villejuif (France); Boisgard, R.; Tavitian, B. [INSERM, U803, F-91400 Orsay (France); Boisgard, R.; Tavitian, B. [CEA, Serv Hosp Frederic Joliot, Lab Imagerie Mol Expt, F-91400 Orsay (France); Roux, J.; Cales, P. [Univ Angers, UPRES EA 3859, Lab Hemodynam Interact Fibrose et Invas Tumorale H, Angers (France); Clerc, J. [Hop Cochin, AP HP, Dept Nucl Med, F-75014 Paris (France)

    2008-07-01

    The hepato-carcinoma-intestine-pancreas (HIP) gene, also called pancreatitis-associated protein-1 (PAP1) or Reg III {alpha}, is activated in most human hepatocellular carcinomas (HCCs) but not in normal liver, which suggests that HIP regulatory sequence could be used as efficient liver tumor-specific promoters to express a therapeutic polynucleotide in liver cancer. The sodium iodide sym-porter (NIS), which has recognized therapeutic and reporter gene properties, is appropriate to evaluate the transcriptional strength and specificity of the HIP promoter in HCC. For this purpose, we constructed a recombinant rat HIP-NIS adeno-viral vector (AdrHIP-NIS), and evaluated its performance as a mediator of selective radio-iodide uptake in tumor hepatocytes. Western blot, immunofluorescence, and iodide uptake assays were performed in AdrHIP-NIS-infected primary hepatocytes and transformed hepatic and non-hepatic cells. Nuclear imaging, tissue counting and immuno-histo-chemistry were performed in normal and HCC-bearing Wistar rats infected with AdrHIP-NIS intra-tumorally or via the hepatic artery. In AdrHIP-NIS-infected transformed hepatic cells, functional NIS was strongly expressed, as in cells infected with a cytomegalovirus-NIS vector. No NIS expression was found in AdrHIP-NIS-infected normal hepatocytes or transformed non-hepatic cells. In rats bearing multi-nodular HCC, AdrHIP-NIS triggered functional NIS expression that was preferential in tumor hepatocytes. Administration of 18 mCi of {sup 131}I resulted in the destruction of AdrHIP-NIS-injected nodules. This study has identified the rHIP regulatory sequence as a potent liver tumor-specific promoter for the transfer of therapeutic genes, and AdrHIP-NIS-mediated. {sup 131}I therapy as a valuable option for the treatment of multi-nodular HCC. (authors)

  13. Temporal variation of the anthropogenic CO{sub 2} and CH{sub 4} contribution in Germany and its role in the global atmospheric carbon cycle; Zeitliche Entwicklung des anthropogenen CO{sub 2}- und CH{sub 4}-Anteils in Deutschland und dessen Bedeutung fuer den globalen atmosphaerischen Kohlenstoffkreislauf

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, M.; Cuntz, M.; Kromer, B.; Levin, I.

    1999-12-01

    The scope of this project is to balance the regional anthropogenic greenhouse gas emissions based on atmospheric measurements. CO{sub 2}, CH{sub 4}, N{sub 2}O, and {sup 222}Rn concentrations were measured continuously over several years at the stations Schauinsland and Heidelberg (Southwest Germany) as well as Neuglobsow and Zingst (Northeast Germany). {sup 222}Rn was used as an atmospheric transport tracer to derive emission rates from concentration changes. Within the uncertainty of our estimate the four selected sites in Germany with different sources characteristics (industrialized vs. agricultural) reflect almost uniform CH{sub 4} flux densities of (0.23{+-}0.07) g CH{sub 4} km{sup -2} s{sup -1}, most likely a result of a rather homogeneous distribution of the diary cows in the responsible catchment area. To obtain a regional budget of N{sub 2}O emissions for Heidelberg, local spots sources (clinics) could be eliminated successfully from the data. The N{sub 2}O flux densities exhibit a strong decrease by 50% from 1996/1997 to 1998. This depletion corresponds to a dramatic reduction of N{sub 2}O emissions in our catchment area from the adipic acid production of the BASF AG at the end of 1997. Concentration and isotopic measurements of CO{sub 2} were combined with the radon tracer method to evaluate quantitatively the fossil fuel CO{sub 2} emissions in Heidelberg and Schauinsland. {delta}{sup 14}C measurements yield a fossil CO{sub 2} flux density of (502{+-}23) t C km{sup -2} a{sup -1} for Heidelberg and (274{+-}8) t C km{sup -2}a{sup -1} for Schauinsland for the period of 1982 to 1998. No significant trend was recorded during this period. However, a significant decrease of the {delta}{sup 13}C signature of fossil CO{sub 2} from (-28{+-}0.6) permille to (-38.5{+-}1) permille from 1982/83 to 1995-1998 clearly indicates changes of the fossil fuel source mix (i.e. gas, oil, and coal). (orig.) [German] Das vorliegende Projekt beschaeftigt sich mit der regionalen Bilanzierung von anthropogenenen Treibhausgasemissionen aus atmosphaerischen Messungen. An den Stationen Schauinsland und Heidelberg (Suedwestdeutschland) sowie Neuglobsow und Zingst (Nordostdeutschland) wurden die CO{sub 2}-, CH{sub 4}-, N{sub 2}O- und {sup 222}Rn-Mischungsverhaeltnisse ueber mehrere Jahre gemessen. Unter Verwendung von {sup 222}Rn als Transporttracer konnten die CH{sub 4}- und N{sub 2}O-Emissionen bilanziert werden. Innerhalb der Unsicherheiten dieser Abschaetzung sind die mittleren CH{sub 4}-Quelldichten fuer die Einzungsgebiete der vier Stationen mit (0.23{+-}0.07)g CH{sub 4} km{sup -2} s{sup -1} identisch, was auf die relativ homogene Bestandsdichte von Milchkuehen, die mit fast 60% zu den CH{sub 4}-Emissionen der jeweiligen Regionen beitragen, zurueckgefuehrt wird. Bei der Auswertung der N{sub 2}O-Datensaetze in Heidelberg konnten die Einfluesse lokaler Punktquellen (Kliniken) eliminiert werden, und es wurde eine 50 prozentige Abnahme der N{sub 2}O-Quelldichte von 1996/97 auf 1998 nachgewiesen. Diese faellt zeitlich zusammen mit einer dramatischen Reduktion der N{sub 2}O-Emissionen aus der Adipinsaeureproduktion der BASF AG Ende 1997. Eine quantitative Auswertung der CO{sub 2}-Emissionen in Heidelberg und am Schauinsland konnte durch eine Analyse der CO{sub 2}-Konzentrations- und Isotopenmessreihen unter Verwendung der Radon-Tracer-Methode erreicht werden. Die aus den atmosphaerischen {delta}{sup 14}C-Messungen fuer die Jahre 1982 bis 1998 bestimmte fossile CO{sub 2}-Quelldichte betraegt in Heidelberg im Mittel (502{+-}23) t C km{sup -2} a{sup -1} und fuer Schauinsland (274{+-}8) t C km{sup -2} a{sup -1}, sie zeigt fuer diesen Zeitraum keinen Trend. Dagegen ist die Aenderung der Zusammensetzung der eingesetzten fossilen Energietraeger (Gas, Erdoel und Kohle) in Heidelberg deutlich an der {delta}{sup 13}C-Signatur des fossilen CO{sub 2}-Anteils von (-28.6{+-}0.6) permille fuer 1982/83 auf (-38.5{+-}1) permille fuer 1995 bis 1998 zu erkennen. (orig.)

  14. Effect of arbuscular mycorrhizal fungi (AMF) on heavy metal tolerance of alfalfa (Medicago sativa L.) and oat (Avena sativa L.) on a sewage-sludge treated soil; Bedeutung der arbuskulaeren Mykorrhiza (AM) fuer die Schwermetalltoleranz von Luzerne (Medicago sativa L.) und Hafer (Avena sativa L.) auf einem klaerschlammgeduengten Boden

    Energy Technology Data Exchange (ETDEWEB)

    Ricken, B. [Institut fuer Pflanzenernaehrung, Giessen Univ. (Germany); Hoefner, W. [Institut fuer Pflanzenernaehrung, Giessen Univ. (Germany)

    1996-10-01

    In pot experiments with a sewage sludge treated soil, the influence of two arbuscular mycorrhizal fungi (AMF) isolates of Glomus sp. (T6 and D13) on plant growth and on the uptake of heavy metals by alfalfa (Medicago sativa L.) and oat (Avena sativa L.) was investigated. Alfalfa showed an increase of biomass with mycorrhizal infection only to a small extent. In oat AMF inoculation increased the growth of both root and shoot by up to 70% and 55% respectively. Mycorrhization raised the P-content and -uptake in alfalfa, but not in oat, in both roots and shoots. Mycorrhizal alfalfa showed lower Zn-, Cd- and Ni-contents and uptake in roots and shoots. The root length was significantly decreased in mycorrhizal alfalfa plants (up to 38%). The translocation of heavy metals into the shoot of mycorrhizal alfalfa was slightly increased. Mycorrhizal infection of oat led to higher concentrations of Zn, Cd and Ni in the root but to less Zn in the shoot. The translocation of heavy metals to the oat shoot was clearely decreased by mycorrhizal colonisation. This may be based on the ability of fungal tissues to complex heavy metals at the cell walls, thus excluding metals from the shoot. This conclusion is supported by the enhanced root length (up to 78%) of mycorrhizal oat plants in this experiment. The mycorrhizal infection seemed to protect plants against heavy metal pollution in soils. It was obvious that different host plants reacted in different ways. (orig.) [Deutsch] In Gefaessversuchen mit einem klaerschlammgeduengten Boden wurde der Einfluss der arbuskulaeren Mykorrhiza (AM)-Pilzisolate von Glomus sp. (T6 und D13) auf Pflanzenwachstum und Schwermetall (SM)-aufnahme von Luzerne (Medicago sativa L.) und Hafer (Avena sativa L.) untersucht. Das Wachstum von Luzerne wurde durch eine Mykorrhizierung nicht signifikant beeinflusst. Bei Hafer foerderte eine AM-Inokulation mit T6 das Wachstum von Wurzel und Spross bis zu 70% bzw. 55%, zur Reife aber ergab sich gleicher Sprossertrag. Die P-Gehalte in Wurzel und Spross von Luzerne wurden durch die AM gesteigert. Mykorrhizierte Luzerne zeigte sowohl in Wurzel als auch Spross zumeist geringere Zn-, Cd- und Ni-Gehalte auf Aufnahmen als die Kontrolle. Dabei wurde die Verlagerung der SM in den Spross bei mykorrhizierten Pflanzen gefoerdert. Die Wurzellaenge der Luzerne war infolge einer Mykorrhizierung zum Zeitpunkt der 1. Ernte geringfuegig erhoeht, zur 2. Ernte hingegen signifikant reduziert (bis 38%). Bei Hafer bewirkte die Mykorrhiza eine bis zu 78% erhoehte Wurzellaenge und gesteigerte Zn-, Ni- und Cd-Gehalte und Aufnahmen in Wurzel und teilweise auch im Spross. Die Verlagerung der SM in den Spross mykorrbizierter Pflanzen wurde aber gehemmt. Dies laesst eine Bindung der SM in den AM-Strukturen in der Wurzel vermuten. Die Ergebnisse deuten auf eine Filterfunktion der Mykorrhiza gegenueber SM im Boden hin, die bei den verschiedenen Pflanzenarten auf unterschiedlichen Mechanismen zu beruhen scheint. (orig.)

  15. Prognostic significance of gastrointestinal symptoms and diagnosis in relation to the acute radiation syndrome. A retrospective analysis based on the data base SEARCH; Prognostische Bedeutung von gastrointestinalen Symptomen und Befunden in Zusammenhang mit dem aktuen Strahlensyndrom. Eine retrospektive Datenanalyse anhand der Datenbank SEARCH

    Energy Technology Data Exchange (ETDEWEB)

    Hoebbel, Mathias Niklaus Johannes

    2016-11-17

    The following thesis explores the prognostic significance of gastrointestinal symptoms and diagnoses in relation to acute radiation syndrome. This is a retrospective analysis based on the SEARCH (System of Evaluation and Archiving of Radiation Accidents based on Case Histories) database, which was created by a team of researchers in Ulm in 1998. The SEARCH database compiled health status data of individuals involved in a total of 78 ionized radiation accidents between 1945 and 2003. In the past changes in bloodbuilding systems were considered the defining factor in determining a prognosis regarding survival times. Treatment decisions were made in line with these findings, including stem-cell transplants. In recent history, especially after the nuclear disaster in Chernobyl in 1986, the focus shifted onto other organ systems. As a result it has been proven that significant cutaneous damages present an important influence on survival regardless of haematopoiesis. Several researchers have looked at changes in the gastrointestinal tract and possible correlations with radiation induced multiple organ failure. In this paper, all of the data recorded in SEARCH in regards to gastrointestinal symptoms have been analyzed. These include symptoms such as nausea, vomiting and changes in bowel movement as well as their onset and severity. Radiation-induced oral mucositis was also further investigated. Despite the occasional gaps in data in SEARCH, results from the analysis proved that the occurrence of certain symptoms, their severity and their onset were directly correlated to life expectancy, regardless of the dose estimation, and the pending blood test results. An immediate triage of these patients by skilled medical professionals is imperative to accurate categorization.

  16. (Environmental) Panel measures in European law. Importance of the judgement Rs C-176/03 of the European Court, comission/council; (Umwelt-)Strafrechtliche Massnahmen im Europarecht. Bedeutung des EuGH-Urteils Rs C-176/03, Kommission/Rat

    Energy Technology Data Exchange (ETDEWEB)

    Foerster, M.

    2007-07-01

    The problem of international criminality strengthened by the progressive European integration. In particular, this is applied to the environmental criminality, since damages of the environment are not bound to the borders of individual states. Due to the appearing liberty rights, defaults on European level were introduced, whose conversion and penetration ensure effective further effective protection of the right property for the environment. The European Commission raised a complaint against the conversion of the skeleton resolution because of the interference of the union-legal measure into community-legal authority. The Court of Justice of the European Community explained this skeleton resolution as authority adverse. The European Court of Justice assumes community-legal authority authorizes in principle to supranational criminal measures. The practical conditions for it are put out in the contribution under consideration. Finally, the new guideline suggestion KOM(2007) 521 is based on these conditions.

  17. Environmental knowledge. Empirical contributions according to the significance of scientific knowledge in the scope of envionmental education exemplified at BIODIESEL as a fuel; Umweltwissen und oekologisches Handeln. Empirische Beitraege zur Bedeutung naturwissenschaftlicher Bildung im Rahmen der Umwelterziehung am Beispiel der Verwendung von BIODIESEL als Treibstoff fuer moderne Dieselkraftfahrzeuge

    Energy Technology Data Exchange (ETDEWEB)

    Hantke, Guenter

    2006-09-15

    The world-wide heating up of the atmosphere as well as the increasing violence and frequency of extreme weather events mainly are due to the emission of carbon dioxide. The emission of carbon dioxide is based on the power production by combustion of fossil sources of energy. The motor traffic causes a substantial portion of these emissions. Under this aspect, the author of the contribution under consideration examines, to what extent young people are sensitized to the relation between power generation by burning fossil sources of energy and the global climatic change and to ecological acting. In the context of the environment project 'Biodiesel as a pollution-free alternative to mineral diesel oil', 55 young people were informed about these relations and interviewed afterwards. After this project, a fifth of the young people transferred to economical diesel engined vehicles. A third of the young person wants to drive with biodiesel based on economic considerations. Young peoples only have a small amount of knowledge on these relations. Only those young people, who drive with biodiesel, are informed better significantly.

  18. The German law ''KonTraG'' is not sufficient for the energy trading. The importance of the so-called soft factors in successful risk management; Das KonTraG genuegt nicht im Energiehandel. Die Bedeutung der weichen Faktoren im erfolgreichen Risikomanagement

    Energy Technology Data Exchange (ETDEWEB)

    Jaden, E.

    2000-03-20

    The following article deals with the wholescale trading of energy. The energy market in Central Europe is under development with respect to liquidity, transparency, variety of products and standardisation of contracts. It is true that especially the big energy providers have prepared the organisations by way of significant input of own and consulting capacities to match the new German legal requirements for a sufficient risk management, but the long term success of trading in volatile markets will mainly depend on the so-called soft factors such as strategy, attitude in leadership and communication, personnel policy and most important of all the way how to manage price risk positions day by day. These soft factors can very hardly be implemented and controlled by any law, consulting or auditing. (orig.) [German] Der Verfasser eroertert den Engergie-Grosshandel. Hier ist der Markt zur Zeit in Mitteleuropa in Bezug auf Liquiditaet, Transparenz, Produktvielfalt und Standardisierung in der Entwicklungsphase. Zwar haben sich insbesondere die grossen Energiegesellschaften mit viel Eigen- und Beratungsaufwand auf die Erfuellung der neuen gesetzlichen Risikomanagement-Anforderungen vorbereitet, aber beim Handel in volatilen Maerkten sind besonders die durch Gesetz, Beratung und Wirtschaftspruefung schwer in den Griff zu bekommenden so genannten weichen Faktoren wie Strategie, Fuehrungs- und Kommunikationsverhalten, Personalpolitik und als wichtigstes das Preisrisiko-Steuerungsverhalten fuer den langfristigen Erfolg massgebend. (orig.)

  19. 欧洲移民问题及移民政策趋势分析--兼论德国在欧洲移民政策形成中的重要作用%Europ(a)isehe Einwanderungsfrage und Analyse der Tendenzen in der Einwanderungspolitik. Mit Exkurs über Bedeutung der Bundesregierung in der Entstehung der europ(a)isehen Einwanderungspolitik

    Institute of Scientific and Technical Information of China (English)

    陈南雁

    2006-01-01

    二战后西欧各国基于各自独特的历史、现实情况和各自不同的利益诉求,移民政策经历了从宽松到严紧,再到宽严结合的过程.欧洲层面上的移民政策则受国家主权和超国家因素这对矛盾的影响,经历了一个从成员国各自为政到相互协调,再到进一步一体化的过程.其间欧盟国家中一些有影响力的大国如德国,对欧洲移民政策的形成起了至关重要的作用.

  20. The green power privilege of paragraph 39 EEg 2012. On the significance of sales companies within a concern and proofs of origin according to paragraph 55 EEG 2012; Das Gruenstromprivileg des paragraph 39 EEG 2012. Zur Bedeutung von Vertriebsgesellschaften innerhalb eines Konzerns und den Herkunftsnachweisen nach paragraph 55 EEG 2012

    Energy Technology Data Exchange (ETDEWEB)

    Moench, Christoph [Frankfurt Univ., Frankfurt am Main (Germany). Bau-, Planungs- und Umweltrecht; Gleiss Lutz Rechtsanwaelte, Berlin (Germany); Ruttloff, Marc [Frankfurt Univ., Frankfurt am Main (Germany). Bau-, Planungs- und Umweltrecht

    2012-04-15

    The Act on Granting Priority to Renewable Energy regulates in detail the conditions of the remuneration claims of the operators of facilities that only use renewable energy sources or mine gas, to the operators. paragraph 39 sect. 1 EEG 2012 provides exemption clauses in the form of so-called green power privilege, a synonym for green power privilege. This green power privilege enables design possibilities for a sale of electricity from renewable energy sources within the given regulatory framework. This is especially true in the power marketing by a related company of a concern. This is one main theme of the contribution under consideration. Furthermore, the authors report on the proofs of origin according to paragraph 55 EEG 2012, the demands on the power according to paragraph 39 sect. 1 EEG 2012 as well as on the conversion of gray power to green power.

  1. Tumour biological prognosis factors in advanced-stage uterus cervical carcinoma treated primarily by radiation therapy. A study on the significance of tumour oxygenation, tumour vascularisatio, anaemia and tumour proteins for the clinical treatment outcome; Tumorbiologische Prognosefaktoren beim fortgeschrittenen, primaer strahlentherapeutisch behandelten Uteruszervixkarzinom. Eine Untersuchung zur Bedeutung von Tumoroxygenierung, Tumorvaskularisation, Anaemie und Tumorproteinen fuer das klinische Behandlungsergebnis

    Energy Technology Data Exchange (ETDEWEB)

    Haensgen, G.

    2002-07-01

    The goal of the present study was to evaluate tumour biological prognosis factors that might give an indication of a patient's probable radiation sensitivity and hence of the probable clinical outcome. The ultimate goal was to reveal relationships between special tumour biological circumstances and clinical results that would permit a definition of risk factors, thus facilitating an individualised, i.e. optimised treatment.

  2. Inhalt und Rechtspolitische Bedeutung der “Einleitung” des ABGB im Kontext der Kodifikationsgesetzgebng des Frühen 19º Jahrhunderts / Content and Legal-political Significance of “Introduction” of the German Civil Code in Context of Legislative Consolidation in Early Nineteenth Centur

    Directory of Open Access Journals (Sweden)

    Thomas Simon

    2013-07-01

    Full Text Available Wirft man einen Blick auf den Beginn des österreichischen ABGB, dann findet sich dort zunächst eine sog. „Einleitung“. Die „Einleitungen“ der naturrechtlichen Kodifikationen, insbesondere die Interpretationsvorschriften, sind Ausdruck eines justizpolitischen Konflikts, der vor allem seit der zweiten Hälfte des 18. Jh.s rasch an Schärfe zunahm und dann das Verhältnis zwischen monarchischem Gesetzgeber und Justiz bis in die zweite Hälfte des 19. Jh.s bestimmt hat. Hinter der Umstellung auf ein kodifiziertes Recht seit dem ausgehenden 18. Jh. stand dann der Anspruch des Staates, hinfort selbst das Recht hervorzubringen. Der Justiz wurde dabei die Rolle einer bloß „rechtsanwendenden“ Instanz zugewiesen. In dem Aufsatz wird gezeigt, welche Konflikte zwischen Politik und Justiz daraus entstanden und wie der Staat die Justiz zu disziplinieren suchte. Abstract: If one looks at the beginning of the Austrian ABGB, one finds a so-called “Einleitung”, ie. introduction, first. Those introductions are the expression of a conflict about judicial policy starting to gain momentum in the second half of the 18th century and dominating relations between the monarchic legislator and the judiciary until the second half of the 19th century. Beneath the change towards a codified law since the late 18th century is the demand of the state to from now on create the law on its own. The judiciary was allocated the mere role of a purely norm-applying instance. In this article, it is shown which conflicts between politics and judiciary resulted from this view and how the state tried to discipline the judiciary.

  3. The role of geodata and geotools in sustainable energy planning. The Interreg project 'North Sea Sustainable Energy Planning'; Die Bedeutung von Geodaten und Geowerkzeugen fuer eine nachhaltige Energieplanung. Das Interreg-Projekt 'North Sea Sustainable Energy Planning'

    Energy Technology Data Exchange (ETDEWEB)

    Knies, Juergen [Jade Hochschule Wilhelmshaven/Oldenburg/Elsfleth, Oldenburg (DE). Inst. fuer Angewandte Photogrammetrie und Geoinformatik (IAPG)

    2012-07-01

    The Interreg IVB project 'North Sea Sustainable Energy Planning' is to promote the development of models for regional development in consideration of renewable energy sources and the implementation of measures for higher energy efficiency in consideration of regional and international boundary conditions. Geodata and geotools provide a basis for sustainable energy planning. The Institute of Applied Photogrammetry and Geoinformatics of Jade Hochschule University developed concepts and geotools to support decision-makers in this task. The concepts and tools are presented in this paper.

  4. Der Aufbau mentaler Modelle durch bildliche Darstellungen: Eine experimentalle Studie uber die Bedeutung der Merkmalsdimensionen Elaboriertheit und Strukturierheit im Sachunterricht der Grundschule (The Development of Mental Processes through Graphic Representation with Diverging Degrees of Elaboration and Structurization: An Experimental Study Carried Out in Elementary Science Instruction in Primary School).

    Science.gov (United States)

    Martschinke, Sabine

    1996-01-01

    Examines types of graphical representation as to their suitability for knowledge acquisition in primary grades. Uses the concept of mental models to clarify the relationship between external presentation and internal representation of knowledge. Finds that students who learned with highly elaborated and highly structured pictures displayed the…

  5. Importance and use of an environment management system implementation and innovative optimization approach es using the example of the RAG Deutsche Steinkohle AG; Bedeutung und Nutzung der Implementierung eines Umweltmanagementsystems und innovative Ansaetze zur Optimierung am Beispiel der RAG Deutsche Steinkohle AG

    Energy Technology Data Exchange (ETDEWEB)

    Polysos, Julia

    2014-07-01

    Environmental protection is an important business objective in RAG Deutsche Steinkohle AG (DSK). The management of the company intends the company wide certification according DIN ISO 14001. The law concerning the hard coal financing includes a continuous and socially compatible staff reduction. The company is aimed to manage the hard coal phase-out process considering a sustainable handling of the long-term contamination including public acceptance. The optimization potential includes the implementation and continuation of an area-wide environment management system, the realization of the commissioning management and the environmental evaluation.

  6. MRI of testicular disease. A comparison between Gd-DTPA enhanced scans and unenhanced T[sub 2]-weighted sequences. MR-Tomographie bei Hodenprozessen. Bedeutung Gd-DTPA-verstaerkter Sequenzen im Vergleich mit nativen T[sub 2]-gewichteten Sequenzen

    Energy Technology Data Exchange (ETDEWEB)

    Just, M.; Grebe, P.; Kreitner, K.F.; Thelen, M. (Klinikum der Johannes-Gutenberg-Universitaet Mainz, Radiologische Klinik mit Poliklinik (Germany)); Melchior, S.; Buerger, R.A.; Hohenfellner, R. (Klinikum der Johannes-Gutenberg-Universitaet Mainz, Urologische Klinik und Poliklinik (Germany))

    1992-06-01

    The value of T[sub 1]-weighted sequences after intravenous administration of Gd-DTPA and of T[sub 2]-weighted sequences was compared in 43 patients suspected of having scrotal abnormalities. T[sub 2]-weighted sequences gave better demonstration of the tunica albuginea and better contrast between tumor and parenchyma. The two techniques were equally sensitive for demonstrating testicular tumors but orchitis was better demonstrated on the contrast enhanced sequences. Motion artifacts were less marked in the T[sub 1]-weighted sequences with contrast enhancement. In selected cases, contrast enhancement may be a valuable addition to native protocols. Our experience has indicated that MRI provides specific findings in cases of orchitis which are clinically atypical; this facilitates the decision to conservative treatment and prevents unnecessary exploration of the testes. (orig.).

  7. Selection of optimum blowers is higly important for energy conservation in ventilation and air conditioning engineering: High-performance radial blowers without a housing; Auswahl des optimalen Ventilators fuer Energieeinsparung in der Luft- und Klimatechnik von grosser Bedeutung: Hochleistungs-Radialventilatoren ohne Gehaeuse

    Energy Technology Data Exchange (ETDEWEB)

    Lexis, J. [Ingenieurbuero Beratung und Planung Luft- und Klimatechnik, Feucht bei Nuernberg (Germany)

    1998-12-01

    There isn`t another component in ventilation and air-conditioning whose choice can result in as much energy conservation as the choice of the optimum blower. Awareness of this fact is increasing. (orig.) [Deutsch] Mit keiner anderen Komponente in der Luft- und Klimatechnik kann so viel Energie gespart werden wie mit der Auswahl des optimalen Ventilators. Deshalb wird der Auswahl des Ventilators immer mehr Aufmerksamkeit geschenkt. (orig.)

  8. Sand-lime bricks in commercial and industrial buildings: Optimum sound and heat insulation. Increasing requirements on sound and heat insulation in commercial and industrial buildings; Kalksandstein im Gewerbe- und Industriebau: optimaler Schallschutz und hoher Waermeschutz. Schallschutz- und waermetechnische Gesichtspunkte gewinnen im Gewerbe- und Industriebau immer mehr an Bedeutung

    Energy Technology Data Exchange (ETDEWEB)

    Niebuhr, B.

    1998-01-01

    The contribution shows how sound and heat insulation can be optimized, using real buildings constructed of sand-lime bricks as examples. (GL) [Deutsch] Wie zukunftsbewusst denkende und handelnde Unternehmer optimalen Schall- und Waermeschutz unter einen Hut bringen koennen, wird an konkreten Baukonstruktionen mit dem Wandbaustoff Kalksandstein praxisgerecht verdeutlicht. (GL)

  9. BREF Information Sheet on ''Waste Treatment''. Significance of European plant standards for mechanical biological waste treatment plants; BREF-Merkblatt ''Abfallbehandlung''. Bedeutung europaeischer Anlagenstandards fuer die mechanisch-biologische Abfallbehandlung

    Energy Technology Data Exchange (ETDEWEB)

    Kalmbach, S. [Umweltbundesamt Dessau (Germany)

    2006-07-01

    The IVU Directive of the European Union of 1996 requires that all environmentally relevant industrial plants, this including waste disposal plants, must be equipped with the ''best available techniques'' (BAT). By 30 October 2007 at the latest this is also to apply for all existing plants. The pan-European exchange of information on best available techniques will be facilitated by Best Available Technique Reference (BREF) Notes as provided by the Sevilla Process. The present paper explains the significance of these documents for the member states and their use in Germany. It gives an overview of BREF work already completed or in progress. The author describes the ''Sevilla Process'' and the most important harmonisation outcomes for the BREF Note on ''Waste Treatment'', which comprises chemical and physical treatment, mechanical biological treatment, preparation of refuse-derived fuels, slag processing, solvent recycling, and used oil recycling. He concludes with an outlook on the implementation of the BREF Notes.

  10. Zur Verwendung und Bedeutung des litauischen Partizips der Notwendigkeit imVergleich zum Deutschen. Apie lietuvių kalbos reikiamybės dalyvio vartojimą ir reikšmę gretinant su vokiečių kalba

    Directory of Open Access Journals (Sweden)

    Vaiva Žeimantienė

    2008-01-01

    Full Text Available Reikiamybės dalyviui lietuvių kalbos gramatikose skiriama nedaug dėmesio. Paprastai jis trumpai paminimas skyriuje greta neveikiamosios rūšies dalyvių ir pažymima, kad jis retai tevartojamas.Aprašinėjant vokiečių kalbos konstrukcijos sein+zu-Infinitiv lietuviškus ekvivalentus buvo nus­tatyta, kad greta kitų šios vokiečių kalbos konstrukcijos atitikmenų lietuvių kalboje neretai buvo pastebimos ir konstrukcijos su reikiamybės dalyviu. Galima daryti prielaidą, kad lietuvių kalboje reikiamybės dalyvis kaip ekvivalentas vartotinas tuomet, kai sunku vienareikšmiškai nustatyti, ar vokiečių kalbos konstrukcija sein+zu-Infinitiv pavartota būtinybės, ar galimybės reikšme.Straipsnyje trumpai apžvelgiamas reikiamybės dalyvių vartojimas ir jų reikšmė. Tyrimas remiasi kalbotyros tekstų pavyzdžiais.

  11. Malignoma versus infectious spondylodiscitis in a case of progressive paraplegia: the value of an emergency MRI of the spine for the differential diagnosis; Malignom versus bakterielle Spondylodiszitis: Bedeutung der spinalen MRT fuer die Differentialdiagnose in der Notfallsituation. Beschreibung einer akuten Querschnittssymptomatik

    Energy Technology Data Exchange (ETDEWEB)

    Bremer, M.; Karstens, J.H. [Medizinische Hochschule Hannover (Germany). Abt. fuer Strahlentherapie und Spezielle Onkologie; Herzog, T. [Medizinische Hochschule Hannover (Germany). Abt. fuer Neuroradiologie

    1997-12-01

    Patient and Method: A case of an elderly diabetic patient with acute onset of a progressive neurologic deficit is reported. No malignancy was known so far. The CT of the spine showed a destruction of the 7th and 8th toracic vertebral body with compression of the spinal cord. The patient was referred to the radiotherapist for radiation of a presumed malignant spinal process. Result: For differential diagnosis a magnetic resonance imaging (MRI) of the spine was performed and could lead to the correct diagnosis of an infectious spondylodiscitis. Conclusion: The MRI of the spine has a potential role for correct differentiation between benign and malignant spinal lesions and may thereby assist the radiotherapist in the dicision making in an emergency situation. (orig./MG) [Deutsch] Patient und Methode: Vorgestellt wird eine 70jaehrige Patientin mit akut aufgetretener, progredienter Paraparese beider Beine. Anamnestisch fand sich neben einem Diabetes und einer Osteoporose kein Hinweis auf eine Tumorerkrankung. Aufgrund der im spinalen CT imponierenden ossaeren Destruktion des siebten und achten Brustwirbelkoerpers mit Einengung des Spinalkanals erfolgte unter der Annahme eines Malignoms die Vorstellung beim Strahlentherapeuten. Ergebnis: Erst die vom Radioonkologen im Notfalldienst veranlasste spinale Kernspintomographie (MRT) konnte ein Malignom ausschliessen und ergab die Diagnose einer infektioesen Spondylodiszitis. Schlussfolgerungen: Die spinale MRT kann in einer Situation mit aktuer Querschnittssymptomatik unklarer Aetiologie die entscheidenden differentialdiagnostischen Hinweise liefern und damit im Notfalldienst zur Absicherung einer Bestrahlungsindikation beitragen. (orig./MG)

  12. Der Aufbau mentaler Modelle durch bildliche Darstellungen: Eine experimentalle Studie uber die Bedeutung der Merkmalsdimensionen Elaboriertheit und Strukturierheit im Sachunterricht der Grundschule (The Development of Mental Processes through Graphic Representation with Diverging Degrees of Elaboration and Structurization: An Experimental Study Carried Out in Elementary Science Instruction in Primary School).

    Science.gov (United States)

    Martschinke, Sabine

    1996-01-01

    Examines types of graphical representation as to their suitability for knowledge acquisition in primary grades. Uses the concept of mental models to clarify the relationship between external presentation and internal representation of knowledge. Finds that students who learned with highly elaborated and highly structured pictures displayed the…

  13. Trypsinization severely perturbs radioiodide transport via membrane Na/I symporter proteolysis: implications for reporter gene imaging

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Kyung-Ho [Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710 (Korea, Republic of)], E-mail: jkhope.jung@sbri.co.kr; Paik, Jin-Young [Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710 (Korea, Republic of); Lee, You La; Lee, Yong Jin; Lee, Jaetae [Department of Nuclear Medicine and Pharmacology, School of Medicine, Kyungpook National University, Daegu 702-701 (Korea, Republic of); Lee, Kyung-Han [Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710 (Korea, Republic of)], E-mail: khnm.lee@samsung.com

    2009-11-15

    Introduction: Cell preparation procedures injurious to Na/I symporters (NIS) could deter their usefulness for reporter gene assays and in vivo cell imaging. In this study, we investigated the effects of cell collection by trypsinization on radioiodide transport and in vivo cell imaging results. Methods: The influence of trypsinization procedures on {sup 125}I transport was evaluated using Huh-7/NIS hepatoma cells. The effects of graded concentrations of trypsin and EDTA were assessed on Huh-7/NIS and A431/NIS lung cancer cells. Trypsin-induced NIS proteolysis was investigated by immunoblots of plasma membrane prepared from adenovirus-infected mouse liver tissue. {sup 99m}Tc-O{sub 4}{sup -} scintigraphy was performed in Balb/C nude mice at 1 and 4 h following administration of Huh-7/NIS cells collected with and without trypsin. Results: {sup 125}I Transport ability of Huh-7/NIS cells was severely impaired within minutes of standard trypsinization and further deteriorated up to 24 h after termination of treatment. This perturbation was caused by trypsin, which dose- and time-dependently induced substantial reductions of {sup 125}I uptake in Huh-7/NIS and A431/NIS cells. Immunoblot analysis revealed significant dose- and time-dependent losses of membrane NIS protein by trypsin. NIS proteolysis was completely blocked by soybean trypsin inhibitor, and partial protection was offered by the substrates iodide and perchlorate. On {sup 99m}Tc-O{sub 4}{sup -} scintigraphy of mice, cells prepared by trypsinization were poorly visualized, whereas those collected with a nonenzymatic method showed significantly better uptake and contrast. Conclusion: Trypsinization leads to serious perturbations in iodide accumulating capacity through tryptic degradation of membrane NIS protein. Hence, NIS-based reporter assays and in vivo cell imaging studies may benefit from better-optimized cell cultivation and harvesting procedures.

  14. Genres, généricité et processus de création littéraire dans un journal arabe du début du xxe siècle : al‑Šabāb de Maḥmūd Bayram al‑Tūnisī Literary Creation and Genres in an Arab Periodical at the Beginning of the 20th Century: Al‑Shabab of Mahmûd Bayram al‑Tûnisī על יצירתן של סוגות ספרותיות בכתב עת ערבי בראשית המאה העשרים: אל-שבאב בעריכת מחמוד בייראם אל-טוניסי

    Directory of Open Access Journals (Sweden)

    Ophélie Arroues

    2012-11-01

    Full Text Available Maḥmūd Bayram al‑Tūnisῑ (1893-1961, auteur d’origine tunisienne né en Égypte, fut l’un des acteurs marquants de la Nahḍa journalistique. Il contribua par ses nombreuses publications dans la presse égyptienne et tunisienne au développement de la littérature dialectale et participa au double mouvement d’iḥyā’ et d’iqtibās par la réappropriation de la maqāma et l’écriture de nouvelles. Cet auteur a fondé, rédigé et publié presque à lui seul le journal satirique illustré al‑Šabāb (« La Jeunesse », octobre 1936-mars 1937 lors de son second exil en Tunisie (1932-1937. À partir de textes plus spécifiquement littéraires qui y furent publiés, nous étudierons l’influence du médium sur l’élection de certains genres comme la maqāma et la « littérature d’utopie ». En nous appuyant sur une analyse des dynamiques d’intertextualité et de contamination générique dans le corpus, nous montrerons comment se construisent de nouvelles formes de discours. Nous verrons également comment l’imbrication des écritures journalistique et littéraire fonde un lien étroit entre genres – anciens ou modernes – et spécificités d’une littérature sociale et engagée et, enfin, comment la démarche satirique du journal se reflète dans la réappropriation parodique à des fins critiques de la tradition littéraire.Maḥmūd Bayram al‑Tūnisῑ (1893-1961, an Egyptian born author of Tunisian origin, was one of the prominent actors of the journalistic Nahḍa. He greatly contributed to the development of dialectal literature through his publications in the Egyptian and Tunisian press and he participated in the double movement of ’iḥyā’ and ’iqtibā’ by re-appropriating the maqāma genre and by the writing of short stories. During his second exile in Tunisia (1932-1937, Bayram founded, wrote and published the illustrated, satirical newspaper al‑Šabāb (The Youth, 1936-1937 almost by himself. Based on a selection of published literary texts, we will study the influence of the medium on the choice of certain genres like the maqāma and the “littérature d’utopie”. Thanks to an analysis of the intertextual and transgeneric dynamics in the corpus, we will demonstrate how new forms of discourse are built. We will also see that the interweaving of journalistic and literary writing creates a close bond between genres (old and modern and the specifics of a social and engaged literature. Finally, we will show how the satiric approach of the newspaper is reflected in the parodistic re-appropriation in order to bring criticism to the literary tradition.

  15. Hierarchical NiCo2O4@nickel-sulfide nanoplate arrays for high-performance supercapacitors

    Science.gov (United States)

    Chu, Qingxin; Wang, Wei; Wang, Xiaofeng; Yang, Bin; Liu, Xiaoyang; Chen, Jiuhua

    2015-02-01

    Electrodeposition of nickel sulfide (Ni-S) on NiCo2O4 (NiCo2O4@Ni-S) nanoplate arrays produces a new hierarchical core-shell functional-material. Weak crystalline Ni-S nanosheets have been uniformly coated on the NiCo2O4 nanoplate array obtained by hydrothermal growth. When tested as an electrode for supercapacitors, the NiCo2O4@Ni-S nanoplate arrays have been found to exhibit a significantly improved areal capacitance of 1.85 F cm-2 at a current density of 8 mA cm-2, good rate capability and cycling stability. In addition, the capacitance fading of the NiCo2O4@Ni-S arrays are attributed to the surface coarsening of the Ni-S nanosheets.

  16. Long-term coexistence of non-indigenous species in aquaculture facilities.

    Science.gov (United States)

    Rius, Marc; Heasman, Kevin G; McQuaid, Christopher D

    2011-11-01

    Non-indigenous species (NIS) are a growing problem globally and, in the sea, aquaculture activities are critical vectors for their introduction. Aquaculture introduces NIS, intentionally or unintentionally, and can provide substratum for the establishment of other NIS. Little is known about the co-occurrence of NIS over long periods and we document the coexistence over decades of a farmed NIS (a mussel) with an accidently introduced species (an ascidian). Both are widespread and cause serious fouling problems worldwide. We found partial habitat segregation across depth and the position of rafts within the studied farm, which suggests competitive exclusion of the mussel in dark, sheltered areas and physiological exclusion of the ascidian elsewhere. Both species exhibit massive self-recruitment, with negative effects on the industry, but critically the introduction of NIS through aquaculture facilities also has strong detrimental effects on the natural environment.

  17. Nosocomial infections in the Intesive care unit, University hospital for infectious and tropical diseases, Belgrade, Serbia

    OpenAIRE

    Milošević Ivana; Korać Miloš; Stevanović Goran; Jevtović Đorđe; Milošević Branko; Jovanović Milica; Dulović Olga; Pavlović Milorad

    2014-01-01

    Bacground/Aim. Nosocomial infections (NIs) are an important cause of morbidity, mortality and prolonged hospitalizations. Fifty percent of NIs have been reported in Intensive Care Units. The aim of this study was to determine the frequency and type of NIs among critically ill patients treated in the University Hospital for Infectious and Tropical Diseases, Clinical Centre of Serbia, as well as risk factors for acquiring them. Methods. This prospective cohor...

  18. Costs and benefits to European shipping of ballast-water and hull-fouling treatment: Impacts of native and non-indigenous species

    OpenAIRE

    Fernandes, Jose A.; Santos, Lionel; Vance, Thomas; Fileman, Tim; Smith, David Stanley; Smith, David; Bishop, John D. D.; Viard, Frédérique; Queirós, Ana M.; Merino, Gorka; Buisman, Erik; Austen, Melanie C.

    2016-01-01

    International audience; Maritime transport and shipping are impacted negatively by biofouling, which can result in increased fuel consumption. Thus, costs for fouling reduction can be considered an investment to reduce fuel consumption. Anti-fouling measures also reduce the rate of introduction of non-indigenous species (NIS). Further mitigation measures to reduce the transport of NIS within ballast water and sediments impose additional costs. The estimated operational cost of NIS mitigation ...

  19. National innovation system in less successful developing countries

    DEFF Research Database (Denmark)

    Intarakumnerd, Patarapong; Chairatana, Pun-arj; Tangchitpiboon, Tipawan

    2002-01-01

    This paper, using Thailand as a case study, aims at understanding the national innovation system (NIS) in developing countries which are less successful in technological catching-up. In contrast to developed countries, the development level of Thailand’s NIS does not link to its economic structur...... on factors contributing to the long-running perpetuation of weak and fragmented NIS. © 2002 Elsevier Science B.V. All rights reserved....

  20. Media and Education: Mythologies Old and New

    Directory of Open Access Journals (Sweden)

    Norm Friesen

    2013-03-01

    Full Text Available Norm Friesen untersucht in seinem Beitrag die unterschiedlichen Konzeptualisierungen von Sprechen und Schreiben im rationalistischen und romantischen Paradigma der Spracherfassung und zeigt auf, welche Bedeutung diese Normsetzungen angesichts der Generation von Digital Natives haben.

  1. Dicty_cDB: CFI277 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available nslated Amino Acid sequence (All Frames) Frame A: ---xxxxxxxxxxxxxnxxxxxxkgxxxxxkxxxxkxyxxxxqxkx*cnxknrixtfn...NKTPVKPKLGEYG QKSIKTK Frame C: ---xxxxxxxxxxxxqxxxxxxxrxxxxxkxlxxqxixxxsxxqtxmq*xk*nxhfqslq ingsspxq*nis*vsa

  2. National systems of innovation: determinants and industrial policy measures, empirical evidence for OECD; Sistemas nacionales de innovacion: determinantes y acciones de politica industrial. Evidencia empirica para la OCDE

    Energy Technology Data Exchange (ETDEWEB)

    Hervas, J. L.; Rojas, R.; Sempere, F.; Albors, J.

    2012-11-01

    The paper presents an attempt to tackle the main gaps in the national innovation systems (NIS) literature: the problem specifying the boundaries of the NIS and the lack of connection between theory and empirics. For this purpose, the paper uses 55 countries as sample and constructs an NIS index based on a factor analysis of 28 variables. Empirical evidence shows that a firm's strategies, technology infrastructure, government governance, education and linkages are the main components of the NIS. The implications are important for policy-makers and the academia. (Author) 49 refs.

  3. Adenovirus-mediated and tumor-specific transgene expression of the sodium-iodide symporter from the human telomerase reverse transcriptase promoter enhances killing of lung cancer cell line in vitro

    Institute of Scientific and Technical Information of China (English)

    SHI Yi-zhen; ZHANG Jun; LIU Zeng-li; DU Shou-ying; SHEN Yong-mei

    2010-01-01

    Background The sodium-iodide symporter (NIS) protein can mediate the active radioiodine uptake.The human telomerase reverse transcriptase (hTERT) promoter is known to be selectively reactivated in majority of tumors and hence could be used for tumor targeting.We constructed a recombinant adenovirus containing the human sodium iodide symporter (hNIS) gene directed by the hTERT promoter, characterized the ability of infected cells in uptaking iodide, and explored the therapeutic efficacy of 131I in a lung cancer cell line in vitro.Methods The hTERT promoter was amplified by PCR from DNA isolated from log-phase HepG2 cells, subcloned into lineralized FL*-hNIS/pcDNA3, and then the hTERT-hNIS sequence was subcloned into the shuttle plasmid pAdTrack.The recombinant adenovirus Ad-hTERT-hNIS was constructed by AdEasy system.A positive control adenovirusAd-CMV-hNIS and a negative control adenovirus Ad-CMV were created similarly.A549 cells were transduced with recombinant adenoviruses.125I uptake studies and sodium perchlorate suppression studies were used to confirm hNIS expression and function.Toxic effects of 131I on tumor cells were studied by in vitro clonogenic assay.Results We first successfully constructed an adenovirus mediated transgene expression system of the hNIS under the control of hTERT promoter.When infected with recombinant adenovirus constructs expressing hNIS directed by hTERTand CMV-promoters (Ad-hTERT-hNIS and Ad-CMV-hNIS, respectively), the lung cancer cell line A549 had increased ability to uptake radioiodide up to 23- and 30- fold compared to the control parental cells, respectively.The radioiodide uptake ability of both the Ad-CMV-hNIS and Ad-hTERT-hNIS transduced cell lines were repressed 11-fold by sodium perchlorate (NaCIO4).The subsequent in vitro clonogenic assay of the infected A549 cell line was further repressed to 23% (Ad-CMV-hNIS) and 30% (Ad-hTERT-hNIS) of the control group after receiving radioiodide for 7 hours (P <0.001).Conclusion

  4. Filmrezeptionen und Wertorientierungen Jugendlicher : thematischer Bericht zur Studie: Kunstrezeption und Wertorientierungen Jugendlicher

    OpenAIRE

    Wiedemann, Dieter

    1980-01-01

    Der vorliegende Bericht des Zentralinstitutes für Jugendforschung stellt wesentliche Ergebnisse zur Bedeutung der Freizeittätigkeit Spielfilmrezeption für junge Werktätige und Studenten der DDR dar. Er ist Teil der Studie "Kunstrezeption und Wertorientierungen Jugendlicher". Folgende Themenkomplexe werden untersucht: (1) Zur Bedeutung des Kinobesuchs im Rahmen ausgewählter Freizeittätigkeiten Jugendlicher: Beliebtheit und Häufigkeit von Kinobesuchen; (2) zur Nutzung und Bewertung ausgewählter...

  5. 综合干预对突发性感音神经性聋患者焦虑抑郁情绪及生活质量的影响%The effect of comprehe nis ve intervention on anxiety, depression and quality of life of patients with sudden sensorineural hearing loss

    Institute of Scientific and Technical Information of China (English)

    孙丽; 任秀平; 林乃芬; 杜云

    2015-01-01

    目的:通过对突发性感音神经性聋患者进行综合干预,分析其对焦虑、抑郁情绪及生活质量(QOL)的影响。方法将90例突发性感音神经性聋患者随机分为干预组(45例)和对照组(45例),均接受正规的突发性感音神经性聋常规治疗。对照组按照突发性感音神经性聋护理常规进行护理和健康指导;干预组在此基础上增加认知、行为、家庭社会支持等综合干预。采用Zung焦虑自评量表( SAS )、抑郁自评量表( SDS )和生活质量指数评定量表( QOL)分别于入院3天内及出院前对两组患者进行评估。结果入院3天内两组患者SAS、SDS及QOL评分比较差异均无统计学意义( P>0.05);出院前干预组SAS评分(42.58±8.06)分,较对照组评分(54.28±11.06)分显著下降,差异有统计学意义(t=-4.26,P<0.01),SDS评分(44.13±6.75)也较对照组(52.25±11.26)下降,差异有统计学意义(t=-3.74,P<0.01);生活质量干预组各维度评分显著高于对照组,差异均有统计学意义( P<0.01)。结论护士可根据SAS、SDS对突发性感音神经性聋患者进行评定,实施综合干预,从而可显著改善患者的焦虑、抑郁情绪状态,促进患者康复,全面提高患者的生活质量。%Objective To analyze the effect of comprehensive intervention on anxiety, depression and quality of life of patients with sudden sensorineural hearing loss.Methods A total of 90 cases of sudden sensorineural hearing loss patients were randomly divided into intervention group ( n=45 ) and control group ( n=45 ) .All the patients were given the standard conventional sudden sensorineural hearing loss treatments.The patients of control group were given the regular deafness nursing and health direction, while beyond that the patients of intervention group were given the com-bined comprehensive intervention treatment of cognition, behaving and family social support, etc..Zung Self-rating Anxiety Scale ( SAS) , Self-rating Depression Scale ( SDS) and Quality of Life Index ( QOL) were taken to evaluate the psychological state of patients respectively within 3 days after the admission to hospital and before their discharge from the hospital.Results The comparison and differences of the SAS, SDS and QOL data of the two groups conducted within 3 days after their admission were not statistically significant ( P>0.05 ) .The SAS score of intervention group (42.58±8.06) was decreased obviously compared with that of control group (54.28 ±11.06) before their discharge from hospital ( t=-4.26 , P<0.01 ) .The SDS score of intervention group ( 44.13 ±6.75 ) was also decreased com-pared with that of control group (52.25±11.26), (t=-3.74, P<0.01) .The scores based on different dimensions of QOL of intervention group were obviously higher than those of control group ( P<0.01 ) .Conclusions SAS and SDS could be used by the nursing staff to evaluate the patients with sudden sensorineural hearing loss.And comprehen-sive interventions could be carried out to improve the psychological state of the patients'depression and anxiety, and to promote their rehabilitation and to enhance the overall quality of life of the patients.

  6. Dawr al-Ḥarakāt al-Nisā’īyah fī I’ādat Taskhīl Qānūn al-Mujtama’ al-Islāmī bi Indūnīsīyā

    Directory of Open Access Journals (Sweden)

    Khoiruddin Nasution

    2014-03-01

    Full Text Available This article deals with the role of the Indonesian women's movement in the reformation of Indonesian Islamic marriage law. The author took an historical approach in conducting the research; hence the main sources are the books and articles that contain the historical record of the events concerned. The study shows that the role of the Indonesian Women's Movement is very significant in the reform of Indonesian marriage law. The birth of the Indonesian feminist movement is said to date back to the 1900's, since it was intimately allied to the national awakening. Raden Ajeng Kartini, who lived from 1879 to 1904, was the first woman to privately demand the emancipation of women. However she was principally concerned with improving women's participation by means of education, such as learning household duties, dress-making classes, course of child welfare, and the like. Rohana Kudus in Minangkabau, West Sumatra, was the first woman who privately and directly criticized the bad effects of child marriage, polygamy and one side divorce.Copyright (c 2014 by SDI. All right reserved.DOI: 10.15408/sdi.v8i2.691

  7. Molecular In Vivo Imaging Using a Noninvasive Cardiac-Specific MLC-2v Promoter Driven Dual-Gene Recombinant Lentivirus Monitoring System.

    Directory of Open Access Journals (Sweden)

    Miao Zhang

    Full Text Available Our study aimed to demonstrate the feasibility of using the sodium/iodide symporter (NIS to monitor vascular endothelial growth factor (VEGF165 expression in vivo.We constructed a recombinant lentivirus plasmid with the MLC-2v promoter driving the sodium/iodide symporter (NIS reporter gene linked to the VEGF165 gene. Expression of NIS and VEGF gene were identified by Western blot. On days 2 and 54, 99mTc-MIBI imaging was used to evaluate changes in myocardial ischemia. Noninvasive 125I micro-SPECT/CT imaging was used to assess the expression of NIS reporter gene dynamically over the next 2 months.Western blot analysis showed that both NIS and VEGF165 were highly expressed in rat cardiomyoblast H9C2 cells transduced with Lenti-MLC-2v-NIS--VEGF165. 125I micro-SPECT/CT reporter imaging showed higher uptake in mouse myocardium transduced with Lenti-MLC-2v-VEGF165-IRES-NIS. NIS expression peaked on day 1 after transduction followed by a progressive decline to negligible levels by day 21. On day 1, mean 125I activity value in group 1 was higher than that in group 2 (P 0.05. In group 1 (test group, 99mTc-MIBI SPECT/CT revealed improvements in perfusion and wall thickening in the apical anterior wall. Mean IOD values of NIS and CD34 were significantly higher in group 1 than group 3 (P<0.05. Our study proved mean I-125 uptake was significantly correlated with mean IOD value of NIS and CD34 (P<0.05.This study demonstrates the feasibility of using the NIS gene to monitor VEGF165 expression in a mouse myocardial ischemia model.

  8. Information Quality of a Nursing Information System depends on the nurses: A combined quantitative and qualitative evaluation

    NARCIS (Netherlands)

    Michel-Verkerke, M.B.

    2012-01-01

    Purpose Providing access to patient information is the key factor in nurses’ adoption of a Nursing Information System (NIS). In this study the requirements for information quality and the perceived quality of information are investigated. A teaching hospital in the Netherlands has developed a NIS as

  9. Surface-enhanced Raman scattering biosensor for DNA detection on nanoparticle island substrates

    DEFF Research Database (Denmark)

    Yuan, Scott Wu; Ho, Ho Pui; Lee, Rebecca K.Y.

    2009-01-01

    We present a study on the surface-enhanced Raman scattering (SERS) properties of Ag nanoparticle island substrates (NIS) and their applications for target oligonucleotide (OND) detection. It has been found that the surface nanostructure of NIS samples can be controlled with a good degree of repro...

  10. Nutrition impact symptoms, handgrip strength and nutritional risk in hospitalized patients with gastroenterological and liver diseases

    DEFF Research Database (Denmark)

    Wilkens Knudsen, Anne; Naver, Astrid; Bisgaard, Karen;

    2015-01-01

    OBJECTIVE: Malnutrition is common among patients with diseases of the liver and gastrointestinal tract. Nutritional intake may be negatively affected by nutrition impact symptoms (NIS). Therefore, the aims were to assess: 1) the prevalence of NIS in this group of patients and 2) the relationship ...

  11. Iodide kinetics and experimental I-131 therapy in a xenotransplanted human sodium-iodide symporter-transfected human follicular thyroid carcinoma cell line

    NARCIS (Netherlands)

    Smit, J.W.A.; Elst, van der J.P.; Karperien, M.; Que, I.; Stokkel, M.; Heide, van der D.; Romijn, J.A.

    2002-01-01

    Uptake of iodide is a prerequisite for radioiodide therapy in thyroid cancer. However, loss of iodide uptake is frequently observed in metastasized thyroid cancer, which may be explained by diminished expression of the human sodium-iodide symporter (hNIS). We studied whether transfection of hNIS int

  12. In vivo molecular imaging and radionuclide (131I therapy of human nasopharyngeal carcinoma cells transfected with a lentivirus expressing sodium iodide symporter.

    Directory of Open Access Journals (Sweden)

    Shuo Shi

    Full Text Available Despite recent improvements in the survival rates for nasopharyngeal carcinoma (NPC, novel treatment strategies are required to improve distant metastasis-free survival. The sodium iodine symporter (NIS gene has been applied for in vivo imaging and cancer therapy. In this study, we examined the potential of NIS gene therapy as a therapeutic approach in NPC by performing non-invasive imaging using 125I and 131I therapy in vivo.We constructed a lentiviral vector expressing NIS and enhanced green fluorescent protein (EGFP under the control of the human elongation factor-1α (EF1α promoter, and stably transfected the vector into CNE-2Z NPC cells to create CNE-2Z-NIS cells. CNE-2Z and CNE-2Z-NIS tumor xenografts were established in nude mice; 125I uptake, accumulation and efflux were measured using micro-SPECT/CT imaging; the therapeutic effects of treatment with 131I were assessed over 25 days by measuring tumor volume and immunohistochemical staining of the excised tumors.qPCR, immunofluorescence and Western blotting confirmed that CNE-2Z-NIS cells expressed high levels of NIS mRNA and protein. CNE-2Z-NIS cells and xenografts took up and accumulated significantly more 125I than CNE-2Z cells and xenografts. In vitro, 131I significantly reduced the clonogenic survival of CNE-2Z-NIS cells. In vivo, 131I effectively inhibited the growth of CNE-2Z-NIS xenografts. At the end of 131I therapy, CNE-2Z-NIS xenograft tumor cells expressed higher levels of NIS and caspase-3 and lower levels of Ki-67.Lentiviruses effectively delivered and mediated long-lasting expression of NIS in CNE-2Z cells which enabled uptake and accumulation of radioisotopes and provided a significant therapeutic effect in an in vivo model of NPC. NIS-mediated radioiodine treatment merits further investigation as a potentially effective, low toxicity therapeutic strategy for NPC.

  13. Quantitative immunohistochemical analysis reveals association between sodium iodide symporter and estrogen receptor expression in breast cancer.

    Directory of Open Access Journals (Sweden)

    Sushmita Chatterjee

    Full Text Available BACKGROUND: Human sodium iodide symporter (hNIS gene over-expression is under active consideration worldwide as an alternative target molecule for breast cancer (BC diagnosis and targeted radio-iodine treatment. However, the field demands better stratified analysis of endogenous hNIS expression across major BC subtypes. Therefore, we have analyzed subtype-specific variation of hNIS overexpression in breast tumor tissue samples by immunohistochemistry (IHC and also report the development of a homogeneous, quantitative analysis method of digital IHC images. METHODS: hNIS expression was analyzed from 108 BC tissue samples by IHC. Sub-cellular localization of hNIS protein was analyzed by dual immunofluorescence (IF staining method using hNIS and HER2 antibodies. An ImageJ based two-step digital analysis method was developed and applied for the bias-free analysis of the images. RESULTS: Staining of the tumor samples show 70% cases are hNIS positive indicating high incidence of hNIS positive cases in BC. More importantly, a subtype specific analysis done for the first time shows that hNIS expression is overly dominated in estrogen receptor (ER positive cases than the receptor negative cases. Further, 56% of the ER+ve, PgR+ve, HER2-ve and 36% of ER+ve, PgR+ve, HER2+ve cases show highest intensity staining equivalent to the thyroid tissue. A significant positive correlation is also observed between hNIS and estrogen receptor expression (p = 0.0033, CI = 95% suggesting hNIS mediated targeted radio-iodine therapy procedures may benefit both ER+ve, PgR+ve, HER2-ve as well as HER2+ve cases. Further, in a few cases, hNIS and HER2 protein localization is demonstrated by overlapping membrane co-expression. ImageJ based image analysis method shows over 70% match with manual pathological scoring method. CONCLUSION: The study indicates a positive link between hNIS and ER expression in BC. The quantitative IHC image analysis method reported here will

  14. Increases in doxorubicin sensitivity and radioiodide uptake by transfecting shMDR and sodium/iodide symporter gene in cancer cells expressing multidrug resistance

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Sohn Joo; Lee, Yong Jin; Lee, You La; Choi, Chang Ik; Lee, Sang Woo; Yoo, Jeong Soo; Ahn, Byeong Cheol; Lee, In Kyu; Lee, Jae Tae [Kyungpook National University, Daegu (Korea, Republic of)

    2007-06-15

    Multidrug resistance (MDR) of the cancer cells related to mdr1 gene expression can be effectively treated by selective short hairpin RNA for mdr1 gene (shMDR). Sodium/iodide symporter (NIS) gene is well known to have both reporter and therapeutic gene characteristics. We have co-transfected both shMDR and NIS gene into colon cancer cells (HCT15 cell) expressing MDR and Tc-99m sestamibi and I-125 uptake were measured. In addition, cytotoxic effects of doxorubicin and I-131 therapy were also assessed after transfection. At first, shMDR was transfected with liposome reagent into human embryonic kidney cells (HEK293) and HCT cells. shMDR transfection was confirmed by RT-PCR and western blot analysis. Adenovirus expressing NIS (Ad-NIS) gene and shMDR (Ad-shMDR) were co-transfected with Ad-NIS into HCT15 cells. Forty-eight hours after infection, inhibition of P-gycoprotein (Pgp) function by shMDR was analyzed by a change of Tc-99m sestamibi uptake and doxorubicin cytotoxicity, and functional activity of induced NIS gene expression was assessed with I-125 uptake assay. In HEK293 cells transfected with shMDR, mdr1 mRNA and Pgp protein expressions were down regulated. HCT15 cells infected with 20 MOI of Ad-NIS was higher NIS protein expression than control cells. After transfection of 300 MOI of Ad-shMDR either with or without 10 MOI of Ad-NIS, uptake of Tc-99m sestamibi increased up to 1.5-fold than control cells. HCT15 cells infected with 10 MOI of Ad-NIS showed approximately 25-fold higher I-125 uptake than control cells. Cotransfection of Ad-shMDR and Ad-NIS resulted in enhanced cytotoxic by doxorubicin in HCT15 cells. I-131 treatment on HCT15 cells infected with 20 MOI of Ad-NIS revealed increased cytotoxic effect. Suppression of mdr1 gene expression, retention of Tc-99m sestamibi, enhanced doxorubicin cytotoxicity and increases in I-125 uptake were achieved in MDR expressing cancer cell by co-transfection of shMDR and NIS gene. Dual therapy with doxorubicin and

  15. Surface-enhanced Raman scattering biosensor for DNA detection on nanoparticle island substrates

    DEFF Research Database (Denmark)

    Yuan, Scott Wu; Ho, Ho Pui; Lee, Rebecca K.Y.

    2009-01-01

    We present a study on the surface-enhanced Raman scattering (SERS) properties of Ag nanoparticle island substrates (NIS) and their applications for target oligonucleotide (OND) detection. It has been found that the surface nanostructure of NIS samples can be controlled with a good degree....... Detection of target OND was performed with a sandwich format in which the target OND was hybridized both to a capture OND immobilized on the NIS substrate, and a detection OND conjugated with a Raman-active dye for SERS signal generation.We compare the detection performance of two strategies based...... of reproducibility, and a high SERS enhancement can be achieved when the peak extinction wavelength of NIS is tuned to a spectral window (∼60 nm) between the excitation wavelength and the scattered Raman wavelength. The highest SERS enhancement was obtained from the NIS substrates with a nominal thickness of 50Å...

  16. Effects of different nonionic surfactants on in vitro fermentation characteristics of cereal straws.

    Science.gov (United States)

    Cong, Z H; Tang, S X; Tan, Z L; Sun, Z H; Zhou, C S; Han, X F; Wang, M; Ren, G P

    2009-03-01

    The effects of 3 nonionic surfactants (NIS), including alkyl polyglucoside (APG), sorbitan trioleate (Span85), and polyoxyethylene sorbitan monostearate (Tween80), on in vitro fermentation characteristics of maize stover, rice straw, and wheat straw were examined using an in vitro gas production technique. Four levels each of APG, Span85, and Tween80 [0, 0.02, 0.05, and 0.1% (vol/vol) of incubation solution] were tested in a 4 x 4 x 4 factorial arrangement. The NIS generally increased the in vitro maximal gas production (A), but decreased the lag time of cereal straws. The effects of NIS on the rate of gas production (B) were related to the surfactant type and fermented substrate. The NIS generally increased IVDMD and in vitro OM disappearance (IVOMD) of cereal straws, but responses were dose dependent. The NIS increased total VFA concentration of in vitro fermentation supernatant for maize stover and wheat straw, but decreased total VFA concentration for rice straw. The effects of NIS on the molar proportions of acetate, propionate, and butyrate were dependent on the dose and type of NIS and on fermented substrate. Several interactive effects were noted between or among 3 surfactants (APG, Span85, and Tween80) on in vitro gas production variables, IVD-MD, IVOMD, and VFA for each straw; the optimal combinations of 2 or 3 types of NIS were determined according to the responses of IVDMD and IVOMD to NIS addition. The results of this study suggest that NIS may improve in vitro fermentation of low quality roughages and have potential application as feed additives in ruminant production.

  17. Conserved charged amino acid residues in the extracellular region of sodium/iodide symporter are critical for iodide transport activity

    Directory of Open Access Journals (Sweden)

    Liang Ji-An

    2010-11-01

    Full Text Available Abstract Background Sodium/iodide symporter (NIS mediates the active transport and accumulation of iodide from the blood into the thyroid gland. His-226 located in the extracellular region of NIS has been demonstrated to be critical for iodide transport in our previous study. The conserved charged amino acid residues in the extracellular region of NIS were therefore characterized in this study. Methods Fourteen charged residues (Arg-9, Glu-79, Arg-82, Lys-86, Asp-163, His-226, Arg-228, Asp-233, Asp-237, Arg-239, Arg-241, Asp-311, Asp-322, and Asp-331 were replaced by alanine. Iodide uptake abilities of mutants were evaluated by steady-state and kinetic analysis. The three-dimensional comparative protein structure of NIS was further modeled using sodium/glucose transporter as the reference protein. Results All the NIS mutants were expressed normally in the cells and targeted correctly to the plasma membrane. However, these mutants, except R9A, displayed severe defects on the iodide uptake. Further kinetic analysis revealed that mutations at conserved positively charged amino acid residues in the extracellular region of NIS led to decrease NIS-mediated iodide uptake activity by reducing the maximal rate of iodide transport, while mutations at conserved negatively charged residues led to decrease iodide transport by increasing dissociation between NIS mutants and iodide. Conclusions This is the first report characterizing thoroughly the functional significance of conserved charged amino acid residues in the extracellular region of NIS. Our data suggested that conserved charged amino acid residues, except Arg-9, in the extracellular region of NIS were critical for iodide transport.

  18. Imaging of human sodium-iodide symporter gene expression mediated by recombinant adenovirus in skeletal muscle of living rats

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Hyun Suk; Park, Seong-Wook [Department of Internal Medicine (Cardiology), Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, 138-736, Seoul (Korea); Lee, Heuiran; Kim, Sung Jin [Department of Microbiology, University of Ulsan College of Medicine, Seoul (Korea); Lee, Won Woo [Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam (Korea); Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea); Yang, You-Jung; Moon, Dae Hyuk [Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea)

    2004-09-01

    We evaluated the feasibility of non-invasive imaging of recombinant adenovirus-mediated human sodium-iodide symporter (hNIS) gene expression by {sup 99m}TcO{sub 4}{sup -} scintigraphy in skeletal muscle of rats. Replication-defective recombinant adenovirus encoding hNIS gene [Rad-CMV-hNIS 5 x 10{sup 7}, 2 x 10{sup 8} or 1 x 10{sup 9} plaque forming units (pfu)] or {beta}-galactosidase gene (Rad-CMV-LacZ 1 x 10{sup 9} pfu) was injected into the right biceps femoris muscle of rats (n=5-6 for each group). Three days after gene transfer, scintigraphy was performed using a gamma camera 30 min after injection of {sup 99m}TcO{sub 4}{sup -} (1.85 MBq). An additional two rats injected with 1 x 10{sup 9} pfu of Rad-CMV-hNIS underwent {sup 99m}TcO{sub 4}{sup -} scintigraphy with sodium perchlorate. After the imaging studies, rats were sacrificed for assessment of the biodistribution of {sup 99m}TcO{sub 4}{sup -} and measurement of hNIS mRNA expression. In all the rats injected with 1 x 10{sup 9} pfu of Rad-CMV-hNIS, hNIS expression was successfully imaged by {sup 99m}TcO{sub 4}{sup -} scintigraphy, while rats injected with Rad-CMV-LacZ or lower doses of Rad-CMV-hNIS failed to show uptake. The biodistribution studies indicated that a significantly different amount of {sup 99m}TcO{sub 4}{sup -} was retained in the liver (p<0.001) and the right muscle (p<0.05), with the highest uptake in rats injected with 1 x 10{sup 9} pfu of Rad-CMV-hNIS. The muscular hNIS mRNA level quantified by real-time reverse transcription-polymerase chain reaction was significantly higher in rats injected with 1 x 10{sup 9} pfu of Rad-CMV-hNIS (p<0.05), with a positive correlation with the imaging counts (r=0.810, p<0.05) and the biodistribution (r=0.847, p<0.001). Hot spots in rats injected with 1 x 10{sup 9} pfu of Rad-CMV-hNIS were specifically inhibited by sodium perchlorate. This study illustrated that {sup 99m}TcO{sub 4}{sup -} scintigraphy can monitor Rad-CMV-hNIS-mediated gene expression in

  19. Highly effective nickel sulfide counter electrode catalyst prepared by optimal hydrothermal treatment for quantum dot-sensitized solar cells

    Science.gov (United States)

    Gopi, Chandu V. V. M.; Srinivasa Rao, S.; Kim, Soo-Kyoung; Punnoose, Dinah; Kim, Hee-Je

    2015-02-01

    Nickel sulfide (NiS) thin film has been deposited on a fluorine-doped tin oxide substrate by a hydrothermal method using 3-mercaptopropionic acid and used as an efficient counter electrode (CE) for polysulfide redox reactions in quantum dot-sensitized solar cells (QDSSCs). NiS has low toxicity and environmental compatibility. In the present study, the size of the NiS nanoparticle increases with the hydrothermal deposition time. The performance of the QDSSCs is examined in detail using polysulfide electrolyte with the NiS CE. A TiO2/CdS/CdSe/ZnS-based QDSSC using the NiS CE shows enhanced photovoltaic performance with a power conversion efficiency (PCE) of 3.03%, which is superior to that of a cell with Pt CE (PCE 2.20%) under one sun illumination (AM 1.5, 100 mW cm-2). The improved photovoltaic performance of the NiS-based QDSSC may be attributed to a low charge transfer resistance (5.08 Ω) for the reduction of polysulfide on the CE, indicating greater electrocatalytic activity of the NiS. Electrochemical impedance spectroscopy, cyclic voltammetry, and Tafel-polarization measurements were used to investigate the electrocatalytic activity of the NiS and Pt CEs.

  20. Potentiation of lymphocyte proliferative responses by nickel sulfide

    Science.gov (United States)

    Jaramillo, A.; Sonnenfeld, G.

    1992-01-01

    Crystalline nickel sulfide (NiS) induced a spleen cell proliferation that resembles a mixed lymphocyte reaction (MLR). It depended on cell-cell interaction, induced high levels of interleukin-1 (IL-1) and interleukin-2 (IL-2) and the responding cell subpopulation was composed of CD4+ T lymphocytes. Furthermore, the proliferation was inhibited in a dose-dependent manner by magnesium. Crystalline NiS also increased significantly the spleen cell proliferative response to concanavalin A (Con A) and lipopolysaccharide (LPS) with magnesium potentiating the combined effects of crystalline NiS and mitogens. Interestingly, crystalline NiS did not show any effect on the induction of IL-2 by Con A. The results described herein suggest that crystalline NiS can potentiate both antigenic (MLR) and mitogenic (Con A and LPS) proliferative responses in vitro. Crystalline NiS appears to potentiate these responses by acting in the form of ionic nickel on several intracellular targets for which magnesium ions have different noncompetitive interactions. The effects of magnesium on the potentiating action of crystalline NiS are different depending upon the type of primary stimulatory signal for proliferation (mitogenic or antigenic).

  1. The effect of tanespimycin (17-AAG) on radioiodine accumulation in sodium iodide symporter expressing cells

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Kyoung Hyun; Youn, Hyewon; Song, Myung Geun; Lee, Dong Soo; Chung, June Key [Seoul National Univ. College of Medicine, Seoul (Korea, Republic of)

    2012-12-15

    The heat shock protein 90 inhibitor, tanespimycin, is an anticancer agent known to increase iodine accumulation in normal and cancerous thyroid cells. Iodine accumulation is regulated by membrane proteins such as sodium iodide sym porter (NIS) and pendrin (PDS), and thus we attempted to characterize the effects of tanespimycin on those genes. Cells were incubated with tanespimycin in order to evaluate {sup 125}I accumulation and efflux ability. Radioiodine uptake and efflux were measured by a gamma counter and normalized by protein amount. RT PCR were performed to measure the level of gene expression. After tanespimycin treatment, {sup 125}uptake was in creased by {approx}2.5 fold in FRTL 5, hNIS ARO. and hNIS MDA MB 231 cells, but no changes were detected in the hNIS HeLa cells. Tanespimycin significantly reduced the radioiodine efflux rate only in the FRTL 5 cell. in the FRTL 5 and hNIS ARO cells, PDS mRNA levels were markedly reduced; the only other observed alteration in the levels of NIS mRNA after tanespimtycin treatment was an observed increase in the h hNIS ARO cells. These results indicate that cellular responses against tanespimycin treatment differed between the normal rat thyroid cells and human cancer cells, and the reduction in the {sup 125I} efflux rate by tanespimycin in the normal rat thyroid cells might be attributable to reduced PDS gene expression.

  2. 乳链菌肽Nisin的生物合成及表达调控机制%Biosynthesis and regulation of Nisin

    Institute of Scientific and Technical Information of China (English)

    肖长清; 周洁

    2010-01-01

    乳链菌肽Nisin是乳酸乳球菌(Lactococcus Lactis)产生的一种多肽类抗菌物质,是一种由34个氨基酸组成的羊毛硫细菌素.与Nisin合成有关的基因有11个,构成一个基因簇nisA(Z)BTCIPRKFEG.这些相关基因组成三个操纵子进行转录,分别是nisA(Z)BTCIP、nisRK和nisFEG.Nisin通过NisRK双组分调节系统诱导自身合成,而NisI和NisFEG赋予了Nisin产生茵对Nisin的免疫性.对于Nisin的生物合成机制人们展开了非常广泛的研究.本文对Nisin的结构、Nisin合成相关的基因簇、Nisin的生物合成及表达调控机制以及Nisin产生菌对Nisin的免疫性进行了综述.

  3. Economic and environmental impacts of harmful non-indigenous species in southeast Asia.

    Directory of Open Access Journals (Sweden)

    Le T P Nghiem

    Full Text Available Harmful non-indigenous species (NIS impose great economic and environmental impacts globally, but little is known about their impacts in Southeast Asia. Lack of knowledge of the magnitude of the problem hinders the allocation of appropriate resources for NIS prevention and management. We used benefit-cost analysis embedded in a Monte-Carlo simulation model and analysed economic and environmental impacts of NIS in the region to estimate the total burden of NIS in Southeast Asia. The total annual loss caused by NIS to agriculture, human health and the environment in Southeast Asia is estimated to be US$33.5 billion (5(th and 95(th percentile US$25.8-39.8 billion. Losses and costs to the agricultural sector are estimated to be nearly 90% of the total (US$23.4-33.9 billion, while the annual costs associated with human health and the environment are US$1.85 billion (US$1.4-2.5 billion and US$2.1 billion (US$0.9-3.3 billion, respectively, although these estimates are based on conservative assumptions. We demonstrate that the economic and environmental impacts of NIS in low and middle-income regions can be considerable and that further measures, such as the adoption of regional risk assessment protocols to inform decisions on prevention and control of NIS in Southeast Asia, could be beneficial.

  4. Economic and environmental impacts of harmful non-indigenous species in southeast Asia.

    Science.gov (United States)

    Nghiem, Le T P; Soliman, Tarek; Yeo, Darren C J; Tan, Hugh T W; Evans, Theodore A; Mumford, John D; Keller, Reuben P; Baker, Richard H A; Corlett, Richard T; Carrasco, Luis R

    2013-01-01

    Harmful non-indigenous species (NIS) impose great economic and environmental impacts globally, but little is known about their impacts in Southeast Asia. Lack of knowledge of the magnitude of the problem hinders the allocation of appropriate resources for NIS prevention and management. We used benefit-cost analysis embedded in a Monte-Carlo simulation model and analysed economic and environmental impacts of NIS in the region to estimate the total burden of NIS in Southeast Asia. The total annual loss caused by NIS to agriculture, human health and the environment in Southeast Asia is estimated to be US$33.5 billion (5(th) and 95(th) percentile US$25.8-39.8 billion). Losses and costs to the agricultural sector are estimated to be nearly 90% of the total (US$23.4-33.9 billion), while the annual costs associated with human health and the environment are US$1.85 billion (US$1.4-2.5 billion) and US$2.1 billion (US$0.9-3.3 billion), respectively, although these estimates are based on conservative assumptions. We demonstrate that the economic and environmental impacts of NIS in low and middle-income regions can be considerable and that further measures, such as the adoption of regional risk assessment protocols to inform decisions on prevention and control of NIS in Southeast Asia, could be beneficial.

  5. Comparison of expressed human and mouse sodium/iodide sym-porters reveals differences in transport properties and subcellular localization

    Energy Technology Data Exchange (ETDEWEB)

    Dayem, M.; Basquin, C.; Navarro, V.; Carrier, P.; Marsault, R.; Lindenthal, S.; Pourcher, T. [Univ Nice Sophia Antipolis, Sch Med, CEA, DSV, iBEB, SBTN, TIRO, F-06107 Nice (France); Chang, P. [CNRS, UPMC Biol Dev, UMR 7009, F-06230 Villefranche Sur Mer (France); Huc, S.; Darrouzet, E. [CEA Valrho, DSV, iBEB, SBTN, F-30207 Bagnols Sur Ceze (France)

    2008-07-01

    The active transport of iodide from the blood stream into thyroid follicular cells is mediated by the Na{sup +}/I{sup -} sym-porter (NIS). We studied mouse NIS (mNIS) and found that it catalyzes iodide transport into transfected cells more efficiently than human NIS (hNIS). To further characterize this difference,we compared {sup 125}I, uptake in the transiently transfected human embryonic kidney (HEK) 293 cells. We found that the Vmax for mNIS was four times higher than that for hNIS, and that the iodide transport constant (Km) was 2-5-fold lower for hNIS than mNIS. We also performed immuno-cyto-localization studies and observed that the subcellular distribution of the two ortho-logs differed. While the mouse protein was predominantly found at the plasma membrane, its human ortho-log was intracellular in {approx} 40% of the expressing cells. Using cell surface protein-labeling assays, we found that the plasma membrane localization frequency of the mouse protein was only 2-5-fold higher than that of the human protein, and therefore cannot alone account for,x values. We reasoned that the difference in the obtained Vmax the observed difference could also be caused by a higher turnover number for iodide transport in the mouse protein. We then expressed and analyzed chimeric proteins. The data obtained with these constructs suggest that the iodide recognition site could be located in the region extending from the N-terminus to transmembrane domain 8, and that the region between transmembrane domain 5 and the C-terminus could play a role in the subcellular localization of the protein. (authors)

  6. Importance of geographic origin for invasion success: A case study of the North and Baltic Seas versus the Great Lakes-St. Lawrence River region.

    Science.gov (United States)

    Casties, Isabel; Seebens, Hanno; Briski, Elizabeta

    2016-11-01

    Recently, several studies indicated that species from the Ponto-Caspian region may be evolutionarily predisposed to become nonindigenous species (NIS); however, origin of NIS established in different regions has rarely been compared to confirm these statements. More importantly, if species from certain area/s are proven to be better colonizers, management strategies to control transport vectors coming from those areas must be more stringent, as prevention of new introductions is a cheaper and more effective strategy than eradication or control of established NIS populations. To determine whether species evolved in certain areas have inherent advantages over other species in colonizing new habitats, we explored NIS established in the North and Baltic Seas and Great Lakes-St. Lawrence River regions-two areas intensively studied in concern to NIS, highly invaded by Ponto-Caspian species and with different salinity patterns (marine vs. freshwater). We compared observed numbers of NIS in these two regions to expected numbers of NIS from major donor regions. The expected numbers were calculated based on the available species pool from donor regions, frequency of shipping transit, and an environmental match between donor and recipient regions. A total of 281 NIS established in the North and Baltic Seas and 188 in the Great Lakes-St. Lawrence River. Ponto-Caspian taxa colonized both types of habitats, saltwater areas of the North and Baltic Seas and freshwater of the Great Lakes-St. Lawrence River, in much higher numbers than expected. Propagule pressure (i.e., number of introduced individuals or introduction effort) is of great importance for establishment success of NIS; however in our study, either shipping vector or environmental match between regions did not clarify the high numbers of Ponto-Caspian taxa in our study areas. Although we cannot exclude the influence of other transport vectors, our findings suggest that the origin of the species plays an important role

  7. Telomerase reverse transcriptase promoter-driven expression of iodine pump genes for targeted radioiodine therapy of malignant glioma cells

    Institute of Scientific and Technical Information of China (English)

    Jian Tan; Wei Li; Peng Wang

    2011-01-01

    Radioiodine is a routine therapy for differentiated thyroid cancers. Non-thyroid cancers can intake radioiodine after transfection of the human sodium iodide symporter (hNIS) gene. The human telomerase reverse transcriptase (hTERT) promoter, an excellent tumor-specific promoter, has potential value for targeted gene therapy of glioma. We used the hTERT promoter to drive the expression of the hNIS and human thyroid peroxidase (hTPO) gene as a primary step for testing the effects of radioiodine therapy on malignant glioma. The U87 and U251 cells were co-transfected with two adenoviral vectors, in which the hNIS gene had been coupled to the hTERT promoter and the hTPO gene had been coupled to the CMV promoter, respectively. Then, we performed Western blot, 135l intake and efflux assays, and clonogenic assay with cancer cells. We also did 99mTc tumor imaging of nude mice models. After co-transfection with Ad-hTERT-hNIS and Ad-CMV-hTPO, glioma cells showed the 125l intake almost 1.5 times higher than cells transfected with Ad-hTERT-hNIS alone. Western blots revealed bands of approximately 70 kDa and 110 kDa, consistent with the hNIS and hTPO proteins. In clonogenic assay, approximately 90% of co transfected cells were killed, compared to 50% of control cells after incubated with 37 MBq of 131I. These results demonstrated that radioiodine therapy was effective in treating malignant glioma cell lines following induction of tumor-specific iodide intake by the hTERT promoter-directed hNIS expression in vitro. Co transfected hNIS and hTPO genes can result in increased intake and longer retention of radioiodine. Nude mice harboring xenografts transfected with Ad-hTERT-NIS can take 99mTc scans.

  8. Assessment of the Na/I symporter as a reporter gene to visualize oncolytic adenovirus propagation in peritoneal tumours

    Energy Technology Data Exchange (ETDEWEB)

    Merron, Andrew; McNeish, Iain A. [Queen Mary' s School of Medicine and Dentistry, Centre for Molecular Oncology, Institute of Cancer, London (United Kingdom); Baril, Patrick; Tran, Lucile; Vassaux, Georges [CHU Hotel Dieu, INSERM, Nantes (France); CHU de Nantes, Institut des Maladies de l' Appareil Digestif, Nantes (France); Martin-Duque, Pilar [Instituto Aragones de Ciencias de la Salud, Zaragoza (Spain); Vieja, Antonio de la [Instituto de Investigaciones Biomedicas, Madrid (Spain); Briat, Arnaud [INSERM U877, Grenoble (France); Harrington, Kevin J. [Chester Beatty Laboratories, Institute of Cancer Research, London (United Kingdom)

    2010-07-15

    In vivo imaging of the spread of oncolytic viruses using the Na/I symporter (NIS) has been proposed. Here, we assessed whether the presence of NIS in the viral genome affects the therapeutic efficacy of the oncolytic adenovirus dl922-947 following intraperitoneal administration, in a mouse model of peritoneal ovarian carcinoma. We generated AdAM7, a dl922-947 oncolytic adenovirus encoding the NIS coding sequence. Iodide uptake, NIS expression, infectivity and cell-killing activity of AdAM7, as well as that of relevant controls, were determined in vitro. In vivo, the propagation of this virus in the peritoneal cavity of tumour-bearing mice was determined using SPECT/CT imaging and its therapeutic efficacy was evaluated. In vitro infection of ovarian carcinoma IGROV-1 cells with ADAM7 led to functional expression of NIS. However, the insertion of NIS into the viral genome resulted in a loss of efficacy of the virus in terms of replication and cytotoxicity. In vivo, on SPECT/CT imaging AdAM7 was only detectable in the peritoneal cavity of animals bearing peritoneal ovarian tumours for up to 5 days after intraperitoneal administration. Therapeutic experiments in vivo demonstrated that AdAM7 is as potent as its NIS-negative counterpart. This study demonstrated that despite the detrimental effect observed in vitro, insertion of the reporter gene NIS in an oncolytic adenovirus did not affect its therapeutic efficacy in vivo. We conclude that NIS is a highly relevant reporter gene to monitor the fate of oncolytic adenovectors in live subjects. (orig.)

  9. Treatment of medulloblastoma using an oncolytic measles virus encoding the thyroidal sodium iodide symporter shows enhanced efficacy with radioiodine

    Directory of Open Access Journals (Sweden)

    Hutzen Brian

    2012-11-01

    Full Text Available Abstract Background Medulloblastoma is the most common malignant brain tumor of childhood. Although the clinical outcome for medulloblastoma patients has improved significantly, children afflicted with the disease frequently suffer from debilitating side effects related to the aggressive nature of currently available therapy. Alternative means for treating medulloblastoma are desperately needed. We have previously shown that oncolytic measles virus (MV can selectively target and destroy medulloblastoma tumor cells in localized and disseminated models of the disease. MV-NIS, an oncolytic measles virus that encodes the human thyroidal sodium iodide symporter (NIS, has the potential to deliver targeted radiotherapy to the tumor site and promote a localized bystander effect above and beyond that achieved by MV alone. Methods We evaluated the efficacy of MV-NIS against medulloblastoma cells in vitro and examined their ability to incorporate radioiodine at various timepoints, finding peak uptake at 48 hours post infection. The effects of MV-NIS were also evaluated in mouse xenograft models of localized and disseminated medulloblastoma. Athymic nude mice were injected with D283med-Luc medulloblastoma cells in the caudate putamen (localized disease or right lateral ventricle (disseminated disease and subsequently treated with MV-NIS. Subsets of these mice were given a dose of 131I at 24, 48 or 72 hours later. Results MV-NIS treatment, both by itself and in combination with 131I, elicited tumor stabilization and regression in the treated mice and significantly extended their survival times. Mice given 131I were found to concentrate radioiodine at the site of their tumor implantations. In addition, mice with localized tumors that were given 131I either 24 or 48 hours after MV-NIS treatment exhibited a significant survival advantage over mice given MV-NIS alone. Conclusions These data suggest MV-NIS plus radioiodine may be a potentially useful therapy for

  10. Evaluating nonindigenous species management in a Bayesian networks derived relative risk framework for Padilla Bay, WA, USA.

    Science.gov (United States)

    Herring, Carlie E; Stinson, Jonah; Landis, Wayne G

    2015-10-01

    Many coastal regions are encountering issues with the spread of nonindigenous species (NIS). In this study, we conducted a regional risk assessment using a Bayesian network relative risk model (BN-RRM) to analyze multiple vectors of NIS introductions to Padilla Bay, Washington, a National Estuarine Research Reserve. We had 3 objectives in this study. The 1st objective was to determine whether the BN-RRM could be used to calculate risk from NIS introductions for Padilla Bay. Our 2nd objective was to determine which regions and endpoints were at greatest risk from NIS introductions. Our 3rd objective was to incorporate a management option into the model and predict endpoint risk if it were to be implemented. Eradication can occur at different stages of NIS invasions, such as the elimination of these species before being introduced to the habitat or removal of the species after settlement. We incorporated the ballast water treatment management scenario into the model, observed the risk to the endpoints, and compared this risk with the initial risk estimates. The model results indicated that the southern portion of the bay was at greatest risk because of NIS. Changes in community composition, Dungeness crab, and eelgrass were the endpoints most at risk from NIS introductions. The currents node, which controls the exposure of NIS to the bay from the surrounding marine environment, was the parameter that had the greatest influence on risk. The ballast water management scenario displayed an approximate 1% reduction in risk in this Padilla Bay case study. The models we developed provide an adaptable template for decision makers interested in managing NIS in other coastal regions and large bodies of water.

  11. Onkologie und Nervensystem

    Directory of Open Access Journals (Sweden)

    Grisold W

    2009-01-01

    Full Text Available Die Zusammenhänge zwischen dem Nervensystem und onkologischen Erkrankungen beschränken sich nicht nur auf primäre Hirntumoren, sondern gewinnen bei zahlreichen Tumorerkrankungen, einerseits aufgrund der verbesserten Überlebenszeit, andererseits aufgrund von therapiebedingter Neurotoxizität, an Bedeutung. Es handelt sich um direkte Tumoreinwirkungen wie Metastasen oder meningeale Ausbreitungen, Auswirkung der Therapie im Sinne von Neurotoxizität, metabolischen Phänomenen, Infektionen und paraneoplastische Syndrome. Besondere Bedeutung verdient die Kontrolle von symptomatischen Anfällen und die Behandlung von Schmerzen bei onkologischen Patienten. Supportive und palliative Maßnahmen gewinnen zwar zunehmend an Bedeutung, sind aber in der Neurologie noch weitgehend in Entwicklung. Vertieftes Wissen über neurologische Störungen bei onkologischen Patienten im Sinne einer neuroonkologischen Qualifikation ist anzustreben.

  12. Al-Tafkīr ḥaul Makānah al-Mar’ah bi Indūnīsiyā baḥth fī Mawqif al-Islām min al-Ḥarkāt al-Nisā’īyah fī al-Qarnayn al-Tāsi’ ‘Ashr wa al-‘Ishrīn al-Milādiyīn

    Directory of Open Access Journals (Sweden)

    Junaidah Munawwaroh

    2014-03-01

    Full Text Available the discourse concerning feminism in Indonesian Muslim society is relatively recent. The emergence of such a movement only goes back to the early twentieth century, when R.A Kartini, a daughter of Jepara Resident, struggled for an equal position for man and women in public life. it seems that the movement has tried to respon a particular challenge faced by most women in the Dutch-East Indies who have been discriminated againts and denied access to education. as the movement speards, the discourse on gender rises to become an important issue among muslims in Indonesia, particularly in academic sphere. It grows rapidly with more extensive and subtantial topics of discussion.Copyright (c 2014 by SDI. All right reserved.DOI: 10.15408/sdi.v6i1.748

  13. Functional magnetic resonance imaging of the kidneys; Funktionelle Magnetresonanztomographie der Nieren

    Energy Technology Data Exchange (ETDEWEB)

    Lanzman, R.S.; Wittsack, H.J. [Universitaetsklinik Duesseldorf, Institut fuer Diagnostische und Interventionelle Radiologie, Duesseldorf (Germany); Notohamiprodjo, M. [Universitaetsklinik Tuebingen, Abteilung fuer Diagnostische und Interventionelle Radiologie, Tuebingen (Germany)

    2015-12-15

    Interest in functional renal magnetic resonance imaging (MRI) has significantly increased in recent years. This review article provides an overview of the most important functional imaging techniques and their potential clinical applications for assessment of native and transplanted kidneys, with special emphasis on the clarification of renal tumors. (orig.) [German] Die funktionelle MRT der Nieren hat in den letzten Jahren zunehmend an Bedeutung gewonnen. In diesem Uebersichtsartikel werden die wichtigsten funktionellen Untersuchungstechniken vorgestellt und deren potenzielle klinische Bedeutung zur Evaluation von Nieren und Transplantatnieren hervorgehoben, wobei ein besonderes Augenmerk auf die Abklaerung von Nierentumoren gelegt wird. (orig.)

  14. Differentialdiagnose des Ulcus cruris

    Directory of Open Access Journals (Sweden)

    Binder B

    2010-01-01

    Full Text Available Das Ulcus cruris ist eine Erkrankung vor allem des höheren Lebensalters. Ungefähr 1 % der Bevölkerung leidet an einer chronischen Wunde. An die 90 % der Ulzera sind vaskulärer Genese, doch gibt es vielfältige weitere Ursachen. Die Kenntnis der relevanten Differentialdiagnosen ist insbesondere bei therapierefraktären Verläufen von Bedeutung. Dazu gehören Neuropathien, myeloproliferative Erkrankungen, Infektionen, Medikamente oder Hauttumore. Für eine erfolgreiche Behandlung des Ulcus cruris ist die Identifikation der Genese von entscheidender Bedeutung, um eine kausale, interdisziplinäre Therapie zu ermöglichen.

  15. Sprechkompetenz im DaF-Unterricht an Slowenischen Gymnasien: von der Theorie zur Praxis

    Directory of Open Access Journals (Sweden)

    Andreja Retelj

    2016-12-01

    Full Text Available Es liegt auf der Hand, dass Fremdsprachenkenntnisse aufgrund der wachsenden Globalisierung stets an Bedeutung gewinnen. Über eine hochentwickelte Fremdsprachenkompetenz zu verfügen, ist in der heutigen Gesellschaft fast zur Selbstverständlichkeit geworden. Durch die wachsenden wirtschaftlichen Kontakte gewinnt vor allem die mündliche Kommunikation immer mehr an Bedeutung und die Erwartungen an Fremdsprachenlernende, in verschiedenen Sprachsituationen mündlich schnell und angemessen kommunizieren zu können, nehmen aus diesem Grund ständig zu.

  16. Graffiti als ,doing Illegalityʼ. Perspektiven einer Cultural Criminology

    Directory of Open Access Journals (Sweden)

    Sascha Schierz

    2014-10-01

    Full Text Available Auseinandersetzungen mit dem Thema Graffiti in der Stadt lassen sich seit einigen Jahren gehäuft in unterschiedlichen Diskurssträngen der Kriminologie oder aber Kriminalprävention auffinden. Sie gelten weitestgehend als Symbole für Kriminalität und werden mit Furcht assoziiert. Gleichzeitig wird ihnen in künstlerischen Events verstärkt die Bedeutung einer neuen Kunstform im öffentlichen Raum angetragen. Der Artikel untersucht im Sinne einer Cultural Criminology die Praktiken und Diskurse, die illegalen Graffiti in der Stadt eine Bedeutung zuweisen, wie die Praxis der Writer, sich zwischen diesen Bedeutungsräumen zu verorten.

  17. Kunst als kontemplativer Raum. Das künstlerische Werk der Anni Albers

    OpenAIRE

    Ardjah, Melanie

    2011-01-01

    Die Künstlerin Anni Albers wird in der Forschung im allgemeinen dem Bereich der Textilkunst zugeordnet, obwohl ihr künstlerisches Schaffen weit darüber hinaus von Bedeutung ist. Findet sie in der Literatur Erwähnung, dann im Kontext des Bauhauses und der dort ansässigen Webereiwerkstatt. Erst durch ihre Emigration in die USA konnte dort eine Rezeption ihres Werkes einsetzen, die Anni Albers in einen komplexeren Zusammenhang stellt. Ihre künstlerische Position umfassend in seiner Bedeutung dar...

  18. A study on national innovation system for the improvement of nuclear R and D performance

    Energy Technology Data Exchange (ETDEWEB)

    Yun, S. W.; Oh, K. B.; Kim, H. J.; Cheong, H. S.; Cheong, I.; Lee, J. H.; Won, B. C.; Cheong, C. E.; Lee, K. H.; Choi, H. M

    2006-01-15

    Review basic concept and analytical method concerned with technological innovation and NIS : concept and defition of technological innovation and NIS, background and evolution of the NIS theory, basic elements of NIS and their relationship. Identification on scientific-technological characteristics of the nuclear R and D and technological innovation : special aspect of the nuclear R and D and technological innovation, difficulty(or complexity) of the nuclear R and D and technological, innovation. Defining organizational-institutional elements of nuclear R and D and innovation allowing for nuclear scientific-technological peculiarity. Developing the model of national nuclear innovation system for analysis of the national R and D performance. Developing the analytical model including performance measure and procedure for national nuclear innovation system led mainly by national Rand D in Korea. Discussion about the national innovation system with other OECD/NEA member countries.

  19. Uued tulijad tutvustavad end diplomilavastustega / Ülle Jantson

    Index Scriptorium Estoniae

    Jantson, Ülle

    2007-01-01

    Janusz Glowacki "Fortinbras jõi end täis" Viljandi Kultuuriakadeemia teatrikunsti eriala 6. lennu esituses (lavastaja Kalju Komissarov ja Sven Heiberg) ja Anton Tshehhovi "Kolm õde" Endla küünis (lavastaja-koreograaf Oleg Titov)

  20. NNSA Staff Member Receives NNSA Recognition

    Energy Technology Data Exchange (ETDEWEB)

    Specht, Elaine S.

    2013-04-01

    This article is intended for publication in the NNSA Nonproliferation and International Security (NIS) Highlights, a quarterly newsletter available in print and e-form. It will be published on the NNSA website and is intended for public release.

  1. Preparation and characterization of chemically deposited nickel sulphide film and its application as a potential counter electrode

    Science.gov (United States)

    Ray, Jaymin; Patel, Mitesh; Ghediya, Prashant; Chaudhuri, Tapas K.

    2016-07-01

    Nickel sulphide (NiS) film has emerged as a counter electrode in many applications, such as thin film batteries, dye sensitized solar cells, and supercapacitors. In this regard, we report the direct liquid coating of pure hexagonal NiS films on glass using a precursor solution of nickel-thiourea complex. A uniform and void free film is observed using scanning electron microscopy. The room temperature electrical conductivity of ˜5 × 103 S cm-1 and the positive thermoelectric power (+6 μV K-1) specify p-type conduction. The temperature variation conductivity in the range 77-300 K depicts the transition of NiS films from conducting to semi-conducting behaviour at certain transition temperatures. Preliminary results from a cyclic voltammetry study shows the feasibility of NiS films as counter electrodes.

  2. Modular RADAR: An Immune System Inspired Search and Response Strategy for Distributed Systems

    CERN Document Server

    Banerjee, Soumya

    2010-01-01

    The Natural Immune System (NIS) is a distributed system that solves challenging search and response problems while operating under constraints imposed by physical space and resource availability. Remarkably, NIS search and response times do not scale appreciably with the physical size of the animal in which its search is conducted. Many distributed systems are engineered to solve analogous problems, and the NIS demonstrates how such engineered systems can achieve desirable scalability. We hypothesize that the architecture of the NIS, composed of a hierarchical decentralized detection network of lymph nodes (LN) facilitates efficient search and response. A sub-modular architecture in which LN numbers and size both scale with organism size is shown to efficiently balance tradeoffs between local antigen detection and global antibody production, leading to nearly scale-invariant detection and response. We characterize the tradeoffs as balancing local and global communication and show that similar tradeoffs exist ...

  3. "Hingede öö" ja sartre'ilik vabadus : Me ei ole valinud surelikkust, aga meist sõltub, kas see täidab meid õhina või masendusega, kannusatb või halvab / Valle-Sten Maiste

    Index Scriptorium Estoniae

    Maiste, Valle-Sten, 1972-

    2009-01-01

    Karl Ristikivi romaani "Hingede öö" ja Hermann Hesse romaani "Stepihunt" põhjal valminud lavastusest Endla teatris, lavastaja ja dramatiseerija Margus Kasterpalu. Esietendus 14. märts 2009 Endla Küünis

  4. Healthcare Cost and Utilization Project (HCUP) - National Inpatient Sample

    Data.gov (United States)

    U.S. Department of Health & Human Services — 2001 to 2013. The National (Nationwide) Inpatient Sample (NIS) is part of a family of databases and software tools developed for the Healthcare Cost and Utilization...

  5. V zamke otkrõlas võstavka fotografi prirodõ Finljandii

    Index Scriptorium Estoniae

    2008-01-01

    Soome loodusfotode näitus "Frozen Horizon" Narva linnuses. Oma töid näitavad Oulu läänis tegutsevad loodusfotograafid Kalervo Ojutkangas, Jorma Luhta, Hannu Hautala, Tauno Kohonen ja Hannu Huttu. Fotograafidest

  6. Juhmuse ja julmuse vahel / Pille-Riin Purje

    Index Scriptorium Estoniae

    Purje, Pille-Riin, 1963-

    1997-01-01

    'Inimpüünis' (koosneb kahest lühinäidendist, Slawomir Mrozheki 'Karol', lavastanud Andres Kask ja Minoru Betsuyaku 'Väljakäik', lavastanud Janek Sarapson) - TPÜ diplomandide lavaprojekt Assauwe tornis

  7. Helsingi Teatriakadeemia tantsukompanii TADaC Eestis 2009 / Evelin Lagle

    Index Scriptorium Estoniae

    Lagle, Evelin, 1986-

    2009-01-01

    Tantsulavastustest: Harri Kuorelahti "Rough Plan" ja Ari Tehnula "Distances - Practices of Kinetic Empathy" 3. mail Pärnu Endla Küünis, 5. mail Tallinnas Kumu auditooriumis ning 7. mail Tartu Sadamateatris

  8. "Hingede öö" ja sartre'ilik vabadus : Me ei ole valinud surelikkust, aga meist sõltub, kas see täidab meid õhina või masendusega, kannusatb või halvab / Valle-Sten Maiste

    Index Scriptorium Estoniae

    Maiste, Valle-Sten, 1972-

    2009-01-01

    Karl Ristikivi romaani "Hingede öö" ja Hermann Hesse romaani "Stepihunt" põhjal valminud lavastusest Endla teatris, lavastaja ja dramatiseerija Margus Kasterpalu. Esietendus 14. märts 2009 Endla Küünis

  9. Assessment of Nonindigenous Species on Coral Reefs in the Hawaiian Islands, with Emphasis on Introduced Invertebrates, November 2, 2002 - November 5, 2003 (NODC Accession 0001419)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Coral reefs on the islands of Kauai, Molokai, Maui, Hawaii and Oahu were surveyed for the presence and impact of marine nonindigenous and cryptogenic species (NIS)...

  10. Nonindigenous near-coastal and estuarine species in the North Pacific: Similarities and disparities in species invasion patterns

    Science.gov (United States)

    Nonindigenous species (NIS) are a pervasive problem throughout the world. To help address this threat, the EPA and USGS developed a hierarchical database known as the Pacific Coast Ecological Information System (PCEIS) that synthesizes existing biogeographic, life history, and i...

  11. Healthcare Cost and Utilization Project (HCUP) - National Inpatient Sample

    Data.gov (United States)

    U.S. Department of Health & Human Services — 2001 forward. The National (Nationwide) Inpatient Sample (NIS) is part of a family of databases and software tools developed for the Healthcare Cost and Utilization...

  12. V zamke otkrõlas võstavka fotografi prirodõ Finljandii

    Index Scriptorium Estoniae

    2008-01-01

    Soome loodusfotode näitus "Frozen Horizon" Narva linnuses. Oma töid näitavad Oulu läänis tegutsevad loodusfotograafid Kalervo Ojutkangas, Jorma Luhta, Hannu Hautala, Tauno Kohonen ja Hannu Huttu. Fotograafidest

  13. Ükskõik kus - see tähendab siin / Ille Rohtlaan

    Index Scriptorium Estoniae

    Rohtlaan, Ille

    2009-01-01

    Karl Ristikivi romaani"Hingede öö" lavastus Endla teatri Küünis, milles on Herman Hesse "Stepihundi" tugevaid mõjutusi, lavastaja ja dramatiseerija Margus Kasterpalu, kunstnik Aime Unt. Esietendus 14. märtsil

  14. Ükskõik kus - see tähendab siin / Ille Rohtlaan

    Index Scriptorium Estoniae

    Rohtlaan, Ille

    2009-01-01

    Karl Ristikivi romaani"Hingede öö" lavastus Endla teatri Küünis, milles on Herman Hesse "Stepihundi" tugevaid mõjutusi, lavastaja ja dramatiseerija Margus Kasterpalu, kunstnik Aime Unt. Esietendus 14. märtsil

  15. Helsingi Teatriakadeemia tantsukompanii TADaC Eestis 2009 / Evelin Lagle

    Index Scriptorium Estoniae

    Lagle, Evelin, 1986-

    2009-01-01

    Tantsulavastustest: Harri Kuorelahti "Rough Plan" ja Ari Tehnula "Distances - Practices of Kinetic Empathy" 3. mail Pärnu Endla Küünis, 5. mail Tallinnas Kumu auditooriumis ning 7. mail Tartu Sadamateatris

  16. Site-selective detection of vibrational modes of an iron atom in a trinuclear complex

    Energy Technology Data Exchange (ETDEWEB)

    Faus, Isabelle, E-mail: faus@rhrk.uni-kl.de; Rackwitz, Sergej; Wolny, Juliusz A. [University of Kaiserslautern, Department of Physics (Germany); Banerjee, Atanu; Kelm, Harald; Krüger, Hans-Jörg [University of Kaiserslautern, Department of Chemistry (Germany); Schlage, Kai; Wille, Hans-Christian [DESY, PETRA III, P01 (Germany); Schünemann, Volker [University of Kaiserslautern, Department of Physics (Germany)

    2016-12-15

    Nuclear inelastic scattering (NIS) experiments on the trinuclear complex [{sup 57}Fe{L-N_4(CH_2Fc)_2} (CH{sub 3}CN){sub 2}](ClO{sub 4}){sub 2} have been performed. The octahedral iron ion in the complex was labelled with {sup 57}Fe and thereby exclusively the vibrational modes of this iron ion have been detected with NIS. The analysis of nuclear forward scattering (NFS) data yields a ferrous low-spin state for the {sup 57}Fe labelled iron ion. The simulation of the partial density of states (pDOS) for the octahedral low-spin iron(II) ion of the complex by density functional theory (DFT) calculations is in excellent agreement with the experimental pDOS of the complex determined from the NIS data obtained at 80 K. Thereby it was possible to assign almost each of the experimentally observed NIS bands to the corresponding molecular vibrational modes.

  17. Uued tulijad tutvustavad end diplomilavastustega / Ülle Jantson

    Index Scriptorium Estoniae

    Jantson, Ülle

    2007-01-01

    Janusz Glowacki "Fortinbras jõi end täis" Viljandi Kultuuriakadeemia teatrikunsti eriala 6. lennu esituses (lavastaja Kalju Komissarov ja Sven Heiberg) ja Anton Tshehhovi "Kolm õde" Endla küünis (lavastaja-koreograaf Oleg Titov)

  18. Radioiodine Therapy of Liver Cancer Cell Following Tissue Specific Sodium Iodide Symporter Gene Transfer and Assessment of Therapeutic Efficacy with Optical Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Byoung Kuk; Lee, You La; Lee, Yong Jin [School of Medicine, Kyungpook National University, Daegu (Korea, Republic of)] (and others)

    2008-10-15

    Cancer specific killing can be achieved by therapeutic gene activated by cancer specific promotor. Expression of sodium iodide symporter (NIS) gene causes transportation and concentration of iodide into the cell, therefore radioiodine treatment after NIS gene transfer to cancer cell could be a form of radionuclide gene therapy. luciferase (Luc) gene transfected cancer cell can be monitored by in vivo optical imaging after D-luciferin injection. Aims of the study are to make vector with both therapeutic NIS gene driven by AFP promoter and reporter Luc gene driven by CMV promoter, to perform hepatocellular carcinoma specific radiodiodine gene therapy by the vector, and assessment of the therapy effect by optical imaging using luciferase expression. A Vector with AFP promoter driven NIS gene and CMV promoter driven Luc gene (AFP-NIS-CMV-Luc) was constructed. Liver cancer cell (HepG2, Huh-7) and non liver cancer cell (HCT-15) were transfected with the vector using liposome. Expression of the NIS gene at mRNA level was elucidated by RT-PCR. Radioiodide uptake, perchlorate blockade, and washout tests were performed and bioluminescence also measured by luminometer in these cells. In vitro clonogenic assay with I-131 was performed. In vivo nuclear imaging was obtained with gamma camera after I-131 intraperitoneal injection. A Vector with AFP-NIS-CMV-Luc was constructed and successfully transfected into HepG2, Huh-7 and HCT-15 cells. HepG2 and Huh-7 cells with AFP-NIS-CMV-Luc gene showed higher iodide uptake than non transfected cells and the higher iodide uptake was totally blocked by addition of perchlorate. HCT-15 cell did not showed any change of iodide uptake by the gene transfection. Transfected cells had higher light output than control cells. In vitro clonogenic assay, transfected HepG2 and Huh-7 cells showed lower colony count than non transfected HepG2 and Huh-7 cells, but transfected HCT-15 cell did not showed any difference than non transfected HCT-15 cell

  19. Factors affecting the efficiency of the BRICSs' national innovation systems: A comparative study based on DEA and Panel Data Analysis

    OpenAIRE

    Cai, Yuezhou

    2011-01-01

    Efficiency scores of the National Innovation System (NIS) for 22 countries, including the BRICS, G7, are calculated with the Data Envelopment Analysis (DEA). Relevant factors that may affect the innovation system efficiency are summarized based on the NIS Approach and the New Growth Theory. Empirical study is further made with the Panel Data Analysis (PDA) and the Principal Component Analysis. The results of efficiency calculation and empirical test show that: (1) The BRICS differ greatly in ...

  20. A Novel Ideal Radionuclide Imaging System for Non-invasively Cell Monitoring built on Baculovirus Backbone by Introducing Sleeping Beauty Transposon.

    Science.gov (United States)

    Lv, Jing; Pan, Yu; Ju, Huijun; Zhou, Jinxin; Cheng, Dengfeng; Shi, Hongcheng; Zhang, Yifan

    2017-03-06

    Sleeping Beauty (SB) transposon is an attractive tool in stable transgene integration both in vitro and in vivo; and we introduced SB transposon into recombinant sodium-iodide symporter baculovirus system (Bac-NIS system) to facilitate long-term expression of recombinant sodium-iodide symporter. In our study, two hybrid baculovirus systems (Bac-eGFP-SB-NeoR and Bac-NIS-SB-NeoR) were successfully constructed and used to infect U87 glioma cells. After G418 selection screening, the Bac-eGFP-SB-NeoR-U87 cells remained eGFP positive, at the 18(th) and 196(th) day post transfection (96.03 ± 0.21% and 97.43 ± 0.81%), while eGFP positive population declined significantly at 18 days in cells transfected with unmodified baculovirus construct. NIS gene expression by Bac-NIS-SB-NeoR-U87 cells was also maintained for 28 weeks as determined by radioiodine uptake assay, reverse transcription-polymerase chain reaction (RT-PCR) and Western Blot (WB) assay. When transplanted in mice, Bac-NIS-SB-NeoR-U87 cells also expressed NIS gene stably as monitored by SPECT imaging for 43 days until the tumor-bearing mice were sacrificed. Herein, we showed that incorporation of SB in Bac-NIS system (hybrid Bac-NIS-SB-NeoR) can achieve a long-term transgene expression and can improve radionuclide imaging in cell tracking and monitoring in vivo.

  1. The Time Lags Effects of Innovation Input on Output in National Innovation Systems: The Case of China

    OpenAIRE

    Dan Wang; Xinli Zhao; Zhenshan Zhang

    2016-01-01

    This paper investigates the time lags effects of innovation input on output in the national innovation systems (NIS). Firstly, we analyze the intrinsic properties of China’s NIS based on the conceptual framework and the causal loop diagram. Secondly, we construct a time lags distribution calculation model and employ the main innovation input indicators to measure the specific characteristics of time lags effects of innovation input on output for China in the period 2000–2012. The results indi...

  2. Proceedings of the Annual Precise Time and Time Interval (PTTI) applications and Planning Meeting (21st), Held in Redondo Beach, California on November 28-30, 1989

    Science.gov (United States)

    1989-01-01

    International Time Scale Algorithm Symposium, 12-13 September, 1988, Turin , Italy, pp. 345-357. [7] Percival, D. B., "Use of robust statistical techniques in...David Howe, Bob Temple , Michael Driscoll, Andrea DeMarchi, and David Allan. We also thank the Calibration Coordination Group of JCTG/CMT-JLC for support...to relate NIS frequency standard to UTC. Traceable frequency calibrations to NIS of standard clocks kept in other Egyptian scientific organizations

  3. Expression Patterns of Glucose Transporter-1 Gene and Thyroid Specific Genes in Human Papillary Thyroid Carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sungeun; Chung, Junekey; Min Haesook and others

    2014-06-15

    The expression of glucose transporter-1 (Glut-1) gene and those of major thyroid-specific genes were examined in papillary carcinoma tissues, and the expressions of these genes were compared with cancer differentiation grades. Twenty-four human papillary carcinoma tissues were included in this study. The expressions of Glut-1- and thyroid-specific genes [sodium/iodide symporter (NIS), thyroid peroxidase, thyroglobulin, TSH receptor and pendrin] were analyzed by RT-PCR. Expression levels were expressed as ratios versus the expression of beta-actin. Pathologic differentiation of papillary carcinoma was classified into a relatively well-differentiated group (n=13) and relatively less differentiated group (n=11). Glut-1 gene expression was significantly higher in the less differentiated group (0.66±0.04) than in the well-differentiated group (0.59±0.07). The expression levels of the NIS, PD and TG genes were significantly higher in the well-differentiated group (NIS: 0.67±0.20, PD: 0.65±0.21, TG: 0.74±0.16) than in the less differentiated group (NIS: 0.36±0.05, PD: 0.49±0.08, TG: 0.60±0.11), respectively. A significant negative correlation was found between Glut-1 and NIS expression, and positive correlations were found between NIS and TG, and between NIS and PD. The NIS, PD and TG genes were highly expressed in well-differentiated thyroid carcinomas, whereas the Glut-1 gene was highly expressed in less differentiated thyroid carcinomas. These findings provide a molecular rationale for the management of papillary carcinoma, especially in the selection of FDG PET or radioiodine whole-body scan and I-131-based therapy.

  4. Progress in study of basic science and clinical implication of thyroid autoantibodies%甲状腺自身抗体的基础和临床进展

    Institute of Scientific and Technical Information of China (English)

    刘超; 杨昱; 陈立立

    2010-01-01

    @@ 迄今已知的人类甲状腺自身抗原有促甲状腺激素受体(TSHR)、甲状腺球蛋白(TG)、甲状腺过氧化物酶(TPO)和钠.碘转运体(NIS)4种,与其相对应的抗体分别为TSHR抗体(TRAbs)、TGAb、TPOAb和anti-NIS.

  5. Proceedings from the Pacific Islands Region Threatened, Endangered, and At-Risk Species Workshop held 6-8 Jun 2006 in Honolulu, Hawaii

    Science.gov (United States)

    2006-06-01

    for NIS introduction Management of invasive vertebrates, especially rodents and ungulates Management of NIS algae and seaweed General approaches for... seaweeds , which are devastating native corals and other sea life. Hawaii was one of the first states to adopt and implement the 2003 Aquatic Invasive...economic impacts. According to Dr. Eldredge, the most important vector for introducing these species is through the aquaculture industry. In addition to

  6. Characterization of Infectivity-Enhanced Conditionally Replicating Adenovectors for Prostate Cancer Radiovirotherapy

    OpenAIRE

    Oneal, Michael J.; Trujillo, Miguel A; Davydova, Julia; McDonough, Samantha; Yamamoto, Masato; Morris, John C.

    2012-01-01

    Prostate cancer (PCa) is the second most commonly diagnosed and sixth leading cause of cancer death in American men and one for which no curative therapy exists after metastasis. To meet this need for novel therapies, our laboratory has previously generated conditionally replicating adenovirus (CRAd) vectors expressing the sodium iodide symporter (hNIS). This virus transduced PCa cells and induced functional NIS expression, allowing for noninvasive tumor imaging and combination therapy with r...

  7. Sodium Iodide Symporter for Nuclear Molecular Imaging and Gene Therapy: From Bedside to Bench and Back

    Directory of Open Access Journals (Sweden)

    Byeong-Cheol Ahn

    2012-01-01

    Full Text Available Molecular imaging, defined as the visual representation, characterization and quantification of biological processes at the cellular and subcellular levels within intact living organisms, can be obtained by various imaging technologies, including nuclear imaging methods. Imaging of normal thyroid tissue and differentiated thyroid cancer, and treatment of thyroid cancer with radioiodine rely on the expression of the sodium iodide symporter (NIS in these cells. NIS is an intrinsic membrane protein with 13 transmembrane domains and it takes up iodide into the cytosol from the extracellular fluid. By transferring NIS function to various cells via gene transfer, the cells can be visualized with gamma or positron emitting radioisotopes such as Tc-99m, I-123, I-131, I-124 and F-18 tetrafluoroborate, which are accumulated by NIS. They can also be treated with beta- or alpha-emitting radionuclides, such as I-131, Re-186, Re-188 and At-211, which are also accumulated by NIS. This article demonstrates the diagnostic and therapeutic applications of NIS as a radionuclide-based reporter gene for trafficking cells and a therapeutic gene for treating cancers.

  8. Impact of nosocomial infections surveillance on nosocomial infection rates: A systematic review.

    Science.gov (United States)

    Li, Ye; Gong, Zhenyu; Lu, Ye; Hu, Guoqing; Cai, Ran; Chen, Zhiping

    2017-06-01

    According to previously studies, nosocomial infections (NIs) surveillance could effectively reduce infection rates. As NIs surveillance systems have been implemented in some hospitals for several years, their impact on NIs need to be explored. Therefore, the purpose of this review is to evaluate the tendency of NI rates during the surveillance period and the impact of surveillance on NI rates. A systematic literature search of the PubMed database to identify papers that evaluated effect of surveillance on NIs, all kinds of NIs occurred during hospitalization or discharged were included. Exclude articles investigated the surveillance combined with other infection control measures. Twenty-five articles were included. NI rates had different levels of reduction during surveillance period, the reduction were not limited by state, department, surveillance system, and NI type. Continuous surveillance had a positive impact on NI, OR/RR were ranged from 0.43 to 0.95. Participation in NI surveillance is associated with reducing infection rates, though RCTs need to further prove the effective role of surveillance. Hospitals may consider to perform NIs surveillance systems according to its own conditions. Copyright © 2017. Published by Elsevier Ltd.

  9. Flower-like nickel cobalt sulfide microspheres modified with nickel sulfide as Pt-free counter electrode for dye-sensitized solar cells

    Science.gov (United States)

    Huo, Jinghao; Wu, Jihuai; Zheng, Min; Tu, Yongguang; Lan, Zhang

    2016-02-01

    The nickel cobalt sulfide/nickel sulfide (NiCo2S4/NiS) microspheres which exhibit flower-like morphologies are synthesized by a two-step hydrothermal method. Then the NiCo2S4/NiS microspheres are deposited on a fluorine doped SnO2 substrate by spin-casting the isopropyl alcohol solution of as-prepared microspheres. The cyclic voltammetry, electrochemical impedance spectroscopy and Tafel tests are employed to measure the electrochemical performance of NiCo2S4/NiS counter electrode. The NiCo2S4 and NiS all are used to improve the conductivity and electrocatalytic ability of the films, and the NiS can also increase the specific surface area of microspheres. The dye-sensitized solar cells (DSSCs) with the NiCo2S4/NiS counter electrode exhibite a power conversion efficiency of 8.8%, which is higher than that of DSSC with Pt counter electrode (8.1%) under the light intensity of 100 mW cm-2 (AM 1.5 G).

  10. Solar power supply to the public grid; Die Einspeisung von Solarstrom ins Netz

    Energy Technology Data Exchange (ETDEWEB)

    Seltmann, T.

    1998-03-01

    Current inverters for grid-connected solar power systems are gaining increasing importance. An outline of grid supply concepts and markets shows a wide variety. (orig.) [Deutsch] Wechselrichter fuer netzgekoppelte Solarstromanlagen gewinnen an Bedeutung. Ein aktueller Ueberblick ueber die Konzepte der Netzeinspeisung und den Markt zeigt eine erstaunlich grosse Vielfalt. (orig.)

  11. Das Ich und der Andere in der psychologischen Technikforschung

    DEFF Research Database (Denmark)

    Schraube, Ernst

    2012-01-01

    subjektiven Dimension menschlicher Lebenspraxis in der heutigen Psychologie beschrieben und gezeigt, warum die damit einhergehende Forschung die Bedeutung der Technik für die Lebensführung der Menschen nur unzureichend untersuchen kann. Daraufhin wird begründet, warum ein präzisiertes konzeptuelles...

  12. Die Suche nach den Gottesteilchen

    CERN Multimedia

    2007-01-01

    2008 wird der größte jemals gebaute Teilchenbeschleuniger in Betrieb genommen Anlässlich des Mathematik-Jahres 2008 hat der Experimentalphysiker der Universität Hamburg und der designierte Generaldirektor des europäischen Zentrums für Teilchenphysik CERN in Genf, Rolf-Dieter Heuer, die Bedeutung des Dialogs zwischen Naturwissenschaftlern und Philosophen hervorgehoben.

  13. Review Essay: Spiegelneuronen in der sozialwissenschaftlichen Diskussion

    OpenAIRE

    Pätzold, Henning

    2010-01-01

    Seit ihrer Entdeckung Mitte der 1990er Jahre sind Spiegelneuronen kontinuierlicher Gegenstand neuro- wie sozialwissenschaftlicher Debatten. Das besondere Interesse von Wissenschaftler/innen außerhalb der biologischen Disziplinen beruht auch darauf, dass Spiegelneuronen nicht nur allgemeine erkenntnistheoretische Bedeutung haben, sondern auch im Zusammenhang mit fundamentalen sozialen Erkenntnis- und Empfindungsformen wie Empathie eine wichtige Rolle zu spielen scheinen. Mit dem Buch von Nadia...

  14. Das Internet in der Biologielehrerausbildung - ein Zwischenbericht

    OpenAIRE

    Bauer, A; Graf, D.

    2003-01-01

    Auch in der universitären Lehre nimmt die Bedeutung des Internet ständig zu. Im Beitrag werden verschiedene Möglichkeiten beschrieben, wie das world wide web schon heute in der Biologielehrerausbildung eingesetzt wird. Vorgestellt werden internetunterstützte Lehre und verschiedene Formen der internetgestützten Lehre, wie Teleteaching, Expertensysteme, virtuelle Seminare und WBT.

  15. Der Zusammenhang zwischen medialem Multitasking, Aufmerksamkeitsfähigkeit und Hyperaktivität bei Jugendlichen

    NARCIS (Netherlands)

    Baumgartner, S.E.; Weeda, W.D.; Huizinga, M.; Kleinen von Königslöw, K.; Förster, K.

    2014-01-01

    Mediales Multitasking ist eine immer häufiger vorkommende Form der Mediennutzung, besonders bei Jugendlichen. Die wachsende Bedeutung dieser Form der Mediennutzung hat zu Bedenken über mögliche Auswirkungen geführt. So wird zum Beispiel angenommen, dass durch die ständige Stimulation mit verschieden

  16. Vorläufige Mitteilung über die Beschaffenheit der Ovarialtasche von Chrysochloris, Galeopithecus und Tupaja

    NARCIS (Netherlands)

    Lange, de Daniel

    1922-01-01

    Im Jahre 1917 ist in den Anatomischen Heften die bekannte und schöne Arbeit Sobotta’s erschienen über das Vorkommen und die Bedeutung der Ovarialtasche bei den Säugetieren ¹). Das Hauptergebniss dieser Arbeit ist, dass bei alien Säugetieren (vielleicht mit Ausnahne der Primaten und des Menschen) die

  17. Macht und Architektur

    DEFF Research Database (Denmark)

    Nagbøl, Søren Peter

    2015-01-01

    für die Lebensbedingungen der Menschen annehmen kann. Die Interpretation kann sowohl an Erlebnissen wie auch an sozialregulativen Strukturen ansetzen. Es geht uns um die Darstellung einer Praxis, in der die Bedeutung von Gebäuden sich nicht darin erschöpft, Menschen als Dach über dem Kopf zu dienen...

  18. Vorläufige Mitteilung über die Beschaffenheit der Ovarialtasche von Chrysochloris, Galeopithecus und Tupaja

    NARCIS (Netherlands)

    Lange, de Daniel

    1922-01-01

    Im Jahre 1917 ist in den Anatomischen Heften die bekannte und schöne Arbeit Sobotta’s erschienen über das Vorkommen und die Bedeutung der Ovarialtasche bei den Säugetieren ¹). Das Hauptergebniss dieser Arbeit ist, dass bei alien Säugetieren (vielleicht mit Ausnahne der Primaten und des Menschen) die

  19. Was ver-spricht der Cyborg?

    OpenAIRE

    Spreen, Dierk

    1997-01-01

    Der Artikel befasst sich kritisch mit der Technisierung des menschlichen Körpers und Bedeutung von Cyborg-Diskursen ('cybernetic organism'). Ausgemessen wird die Metaphorik des Cyborgs und die Ambivalenz der Technisierung des Menschen im Hinblick auf Selbstvorstellungen und Subjekt-Bilder. Dabei wird gezeigt, dass die Cyborgisierung inzwischen keine Zukunftsidee mehr ist, sondern Realität.

  20. Rezension: Ada Lovelace. Die Pionierin der Computertechnik und ihre Nachfolgerinnen von Sybille Krämer (Hg.

    Directory of Open Access Journals (Sweden)

    Bettina Schabschneider

    2015-12-01

    Full Text Available Ein aktueller von Sybille Krämer herausgegebener Sammelband beleuchtet die Bedeutung der Computertechnik-Pionierin Ada Lovelace. Bettina Schabschneider hat den Band einer detaillierten Lektüre unterzogen und für die MEDIENIMPULSE rezensiert …

  1. Zur Texturentwicklung von gewalzten Seltenen-Erden-haltigen Magnesium-Knetlegierungen

    OpenAIRE

    Hantzsche, Kerstin

    2014-01-01

    Einem breiten industriellen Einsatz von Magnesium-Knetlegierungen, insbesondere von Magnesium-Blechen, stehen deren eingeschränkte Umformbarkeit bei geringen Temperaturen und eine Anisotropie der mechanischen Eigenschaften entgegen. Bisherige Untersuchungen, die Umformbarkeit der Bleche durch Prozess- und Legierungsmodifikationen zu verbessern, zeigten, dass der Blechtextur dabei eine herausragende Bedeutung zukommt. Insbesondere bei Mg-Zn-Legierungen mit Seltenen Erden (SE) konnte eine Textu...

  2. Atsevišķu latviešu un lietuviešu valodas adjektīvu semantiskā diferenciācija: latv. šķīsts, liet. skýstas; latv. skaists, liet. skaistùs; latv. tikls, liet. tiklùs

    Directory of Open Access Journals (Sweden)

    Anta Trumpa

    2011-11-01

    Full Text Available Die semantische differenziation von manchen adjektiven der lettischen und litauischen sprache: lett. šķīsts, lit. skýstas; lett, skaists, lit. skaistùs; lett, tikls, lit. tiklùsZusammenfassungDiesen Wortpaaren von semantisch unterschiedlichen Adjektiven der lettischen und litauischen Spra­che (lett. šķīsts ‘tugendhaft, unschuldig, keusch’ : lit. skýstas ‘flüssig; nicht ernst gemeint, unreif’; lett. skaists ‘schön’ : lit. skaistùs ‘grell, klar, rosig; ehrlich, keusch’; lett. tikls ‘tugendhaft, keusch’ : lit. tiklùs ‘treu, leichtgläubig; ehrlich, anständig’ kann man zu Bezeichnungen der Eigenschaften der Sit­tlichkeit zählen, weil mindestens ein Wort im Paar (lett. šķīsts, lett. tikls, lit. tiklùs und lit. skaistùs eine mit Sittlichkeit verbündete Eigenschaft charakterisiert.Die Aufgabe dieses Artikels ist mit der Analyse von diesen Wortpaaren zu konstatieren, welche Sprache die ältere Bedeutung beibehaltet hat, ungefähre Ursachen der Bedeutungsveränderung festzu­stellen und zu bestimmen, ob sie für ganze Gruppe charakteristisch sind.Lit. skýstas hat die ältere Bedeutung ‘flüssig’ beibehaltet. Im Lettischen war anfänglich zwei Be­deutungen: ‘flüssig’ (in Mundarten und ‘rein, sauber’. Die erste Bedeutung ist noch in unseren Zeiten nur als die Erscheinung der Mundarten erhalten worden, aber in der Schriftsprache ist vielleicht wegen des Einflusses der religiösen Texten die Bedeutungsverengung ‘sauber, rein’ → ‘rein von Sünden, tu­gendhaft, keusch’ geschehen.Mehrdeutiges lit. skaistùs hat vermutlich auch die ältere Bedeutung ‘klar, hell’ beibehaltet, aber die Bedeutung ‘tugendhaft, keusch’ hat sich voraussichtlich als übertragene Bedeutung von der Bedeutung ‘rein, hell’ entwickelt und heute ist sie nicht besonders oft verwendet. Im Lettischen ist die Bedeutungs­veränderung ‘hell’ → ‘schön’ geschehen und ist vermutlich die

  3. Environment and cancer as seen by the population of Austria; Umwelt und Krebs aus der Sicht der oesterreichischen Bevoelkerung

    Energy Technology Data Exchange (ETDEWEB)

    Wallner, P.; Haidinger, G. [Vienna Univ. (Austria). Inst. fuer Krebsforschung

    1999-04-01

    The public perception of the importance of environmental factors for carcinogenesis was investigated in a representative sample of Austrians (n=2073) who in 1995 were {>=} 15 years of age. Results show that about 60% of the respondents attribute great importance to environmental pollution as a cause for cancer development. Only smoking ranks higher. Approximately 56% of the respondents rate toxic agents in the workplace to be of great importance. In the case of pesticide residues this is true for 50% and in the case of passive smoking for 44%. High voltage power lines, `earth rays` and `water veins` are rated to be of great importance by about 25% of the respondents. The ratings of women and men do not differ except for the last two esoteric factors, with women giving more importance to them. The survey shows that the role of environmental factors in cancer development is overestimated. A better information of the public about the various cancer risks seems to be necessary. It should be based on the recommendations concerning risk communication, risk didactics and risk comparisons. (orig.) [Deutsch] Mit der vorliegenden Untersuchung sollte erhoben werden, welche Bedeutung aus Sicht der oesterreichischen Bevoelkerung Umweltfaktoren bei der Krebsentstehung zukommt. Im Rahmen der Oesterreichischen Krebsumfrage 1995 wurde eine repraesentative Stichprobe der Bevoelkerung {>=} 15 Jahre (n=2073) befragt. Rund 60% der Respondenten messen der Umweltverschmutzung grosse Bedeutung fuer die Krebsentstehung zu, sie wird damit nach dem Rauchen als wichtigster Faktor angesehen. Die Schadstoffbelastung am Arbeitsplatz hat fuer 56% der Befragten grosse Bedeutung, Pestizide in Lebensmitteln fuer 50% und Passivrauchen fuer 44%. Jeweils ungefaehr 25% der Respondenten messen Hochspannungsleitungen, Erdstrahlen und Wasseradern grosse Wichtigkeit zu. Lediglich Erdstrahlen und Wasseradern haben fuer Frauen groessere Bedeutung als fuer Maenner. Die Ergebnisse der Befragung zeigen, dass

  4. Effect of Co-overexpression of Nisin Key Genes on Nisin Production Improvement in Lactococcus lactis LS01.

    Science.gov (United States)

    Ni, Zhi-Jian; Zhang, Xiao-Yuan; Liu, Fei; Wang, Miao; Hao, Rong-Hua; Ling, Pei-Xue; Zhu, Xi-Qiang

    2017-06-01

    Nisin is a small antimicrobial peptide produced by several subset strains of Lactococcus lactis. To improve nisin yield in the producer L. lactis LS01, we proposed a successive fusion of nisA with nisRK and nisFEG into a single shuttle expression vector pMG36e under the control of the native strong constitutive promoter p32. Subsequently, the recombinant vectors were transplanted into the producer cell through electroporation. Nisin productivity was determined through sodium dodecyl sulfate-polyacrylamide gel electrophoresis and bioactivity assays. Expression of nisin peptide was detected by agar diffusion bioassay, and the transcriptional levels of the target genes involved in nisin biosynthesis were investigated via semi-quantitative reverse transcription PCR expression analysis using 16S ribosomal RNA (rRNA) as an internal control. Results suggested that the introduction of empty plasmid did not affect nisin production of L. lactis LS01, whereas by our rational construction and screening, the engineered strain co-overexpressing nisA, nisRK, and nisFEG achieved a maximum increment in bioactive nisin production with a yield of 2470 IU/ml in shake flasks and 4857 IU/ml in 1.0-l fermenters, which increased by approximately 66.3 and 52.6% (P nisE at transcriptional level were upregulated in the two recombinant strains (LS01/pAR and LS01/pARF), possibly contributing to the improved nisin production. Therefore, this study would provide a potential strategy to improve the economic benefits of nisin manufacture for large-scale industrial production.

  5. GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo.

    Science.gov (United States)

    Barton, Kenneth N; Tyson, Donald; Stricker, Hans; Lew, Young S; Heisey, Gregory; Koul, Sweaty; de la Zerda, Alberto; Yin, Fang-Fang; Yan, Hui; Nagaraja, Tavarekere N; Randall, Kelly Ann; Jin, Guk Kim; Fenstermacher, Joseph D; Jhiang, Sissy; Ho Kim, Jae; Freytag, Svend O; Brown, Stephen L

    2003-09-01

    With the goal of optimizing adenovirus-mediated suicide gene therapy for prostate cancer, we have developed a method based on the human sodium iodide symporter (hNIS) that allows for noninvasive monitoring of adenoviral vectors and quantification of gene expression magnitude and volume within the prostate. A replication-competent adenovirus (Ad5-yCD/mutTK(SR39)rep-hNIS) coexpressing a therapeutic yeast cytosine deaminase (yCD)/mutant herpes simplex virus thymidine kinase (mutTK(SR39)) fusion gene and the hNIS gene was developed. Ad5-yCD/mutTK(SR39)rep-hNIS and a replication-defective hNIS adenovirus (rAd-CMV-FLhNIS) were injected into contralateral lobes of the dog prostate and hNIS activity was monitored in live animals following administration of Na(99m)TcO(4) using gamma camera scintigraphy. Despite the close proximity of the urinary bladder, (99m)TcO(4)(-) uptake was readily detected in the prostate using viral dose levels (10(10) to 10(12) viral particles) that have been safely administered to humans. Due to its rapid clearance and short physical half-life (6 h), it was possible to obtain daily measurements of (99m)TcO(4)(-) uptake in vivo, allowing for dynamic monitoring of reporter gene expression within the prostate as well as biodistribution throughout the body. High-resolution autoradiography of prostate sections coupled with 3D reconstruction of gene expression demonstrated that the magnitude and volume of gene expression could be quantified with submillimeter resolution. Implementation of the GENIS (gene expression of Na/I symporter) technology in the clinic will facilitate optimization of future human gene therapy trials.

  6. Endothelial progenitor cells (EPCs as gene carrier system for rat model of human glioma.

    Directory of Open Access Journals (Sweden)

    Nadimpalli Ravi S Varma

    Full Text Available BACKGROUND: Due to their unique property to migrate to pathological lesions, stem cells are used as a delivery vehicle for therapeutic genes to tumors, especially for glioma. It is critically important to track the movement, localization, engraftment efficiency and functional capability or expression of transgenes of selected cell populations following transplantation. The purposes of this study were to investigate whether 1 intravenously administered, genetically transformed cord blood derived EPCs can carry human sodium iodide symporter (hNIS to the sites of tumors in rat orthotopic model of human glioma and express transgene products, and 2 whether accumulation of these administered EPCs can be tracked by different in vivo imaging modalities. METHODS AND RESULTS: Collected EPCs were cultured and transduced to carry hNIS. Cellular viability, differential capacity and Tc-99m uptake were determined. Five to ten million EPCs were intravenously administered and Tc-99-SPECT images were acquired on day 8, to determine the accumulation of EPCs and expression of transgenes (increase activity of Tc-99m in the tumors. Immunohistochemistry was performed to determine endothelial cell markers and hNIS positive cells in the tumors. Transduced EPCs were also magnetically labeled and accumulation of cells was confirmed by MRI and histochemistry. SPECT analysis showed increased activity of Tc-99m in the tumors that received transduced EPCs, indicative of the expression of transgene (hNIS. Activity of Tc-99m in the tumors was also dependent on the number of administered transduced EPCs. MRI showed the accumulation of magnetically labeled EPCs. Immunohistochemical analysis showed iron and hNIS positive and, human CD31 and vWF positive cells in the tumors. CONCLUSION: EPC was able to carry and express hNIS in glioma following IV administration. SPECT detected migration of EPCs and expression of the hNIS gene. EPCs can be used as gene carrier/delivery system for

  7. Nosocomial infections at Clinical Centre in Kragujevac: Prevalence study

    Directory of Open Access Journals (Sweden)

    Ilić Milena

    2010-01-01

    Full Text Available Introduction Nosocomial infections (NIs are a serious health problem in hospitals worldwide and are followed by a series of consequences, medical, judicial, ethical and economic. Objective The main aim of this study was to assess the magnitude of NIs at the Clinical Centre in Kragujevac. Methods A prevalence study of nosocomial infections was conducted from 16th till 20th May, 2005, within Second National Prevalence Study of Niš in the Republic of Serbia. Results The study included 866 patients. 40 patients had a NI, thus the prevalence of patients with NIs and prevalence of NIs was the same, 4.6%. Among NIs, the most frequent were urinary infections (45.0% followed by surgical-site infections (17.5%, skin and soft tissue infections (15% and pneumonia (12.5%. The rate of NIs was highest at departments of orthopaedics and traumatological surgery (12.0%, followed by intensive care units (8.0%. Overall, 67.5% (27/40 NIs were culture-proved; the leading pathogens were Escherichia coli (40.0%, followed by gram-negative bacteria (Pseudomonas species, Proteus mirabilis, Enterobacteriaceae with equal frequency of 8.0%. Nosocomial infections were significantly more frequent in patients aged ≥65 years (p<0.05, with longer hospitalization ≥8 days (p<0.00, in intensive care patients (p<0.05, patients with an intravenous catheter (p<0.00, urinary catheter (p<0.00, and those under antibiotic therapy (p<0.00. Conclusion This study showed that the prevalence of nosocomial infections in our hospital is similar to the prevalence in the developed countries. The study of prevalence provides a prompt insight into basic epidemiological and ethiological characteristics of nosocomial infections, hence identification of hospital priorities and the need to undertake appropriate prevention measures. .

  8. Comparison of Na{sup +}/I{sup -} symporter expression rate in malignant and benign thyroid diseases: immunohistochemical study

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Do Young; Jeong, Young Jin; Lee, Kyung Eun; Park, Heon Soo; Yoo, Young Hyun; Roh, Mee Sook [Donga University College of Medicine, Busan (Korea, Republic of)

    2006-02-15

    Previous studies have not showed consistent results for the level of expression of sodium/iodide symporter (NIS) in thyroid diseases, especially malignant tumor. We undertook this study to evaluate the distribution of NIS expression in malignant thyroid diseases and compare with that in benign thyoid disease. Total patients were 119 cases (Men 15, 48{+-}13 yrs). Total number of samples were 205 pieces. In malignant thyroid disease, there were 153 samples: 90 in papillary carcinoma, 4 in follicular carcinoma, 2 in medullary carcinoma and 57 in metastatic lymph node. In benign thyroid disease, there were 52 samples: 36 in goiter/cyst, 11 in thyroiditis and 5 in follicular adenoma. Using immunohistochemical methods, we probed 205 samples with monoclonal anti-NIS Ab. Grading of staining was scored as 0 (negative or absent), 1 (weakly positive), 2 (moderately positive) or 3 (strongly positive). Expression rate (ER) of NIS positivity in individual disease entity was expressed as percentage of total number divided by number in 2 plus 3 grade. ERs of malignant thyroid diseases were 63% in papillary carcinoma, 81% in metastatic lymph node, 71% in follicular carcinoma and 100% in medullary carcinoma. ERs of benign thyroid disease were 53% in goiter/cyst, 64% in thyroiditis and 40% in follicular adenoma. ER of benign thyroid deceases was higher than benign thyroid diseases (71% vs 54%). Grading of NIS expression in papillary carcinoma or goiter/cyst was heterogeneously distributed in considerable cases. Normal tissue also showed heterogeneous distribution or NIS expression, which was not correlated with that of primary lesion. In papillary thyroid carcinoma, distribution of NIS expression was heterogeneous and increased, and not different compared with that of benign thyroid disease.

  9. DNA Methylation in Thyroid Tumorigenesis

    Energy Technology Data Exchange (ETDEWEB)

    Stephen, Josena K., E-mail: jstephe2@hfhs.org [Department of Otolaryngology/Head and Neck Surgery, Henry Ford Hospital, Detroit, MI 48202 (United States); Chitale, Dhananjay [Department of Pathology, Henry Ford Hospital, Detroit, MI 48202 (United States); Narra, Vinod [Essex Surgical Associates, PC, Beverly, MA 01915 (United States); Chen, Kang Mei; Sawhney, Raja; Worsham, Maria J. [Department of Otolaryngology/Head and Neck Surgery, Henry Ford Hospital, Detroit, MI 48202 (United States)

    2011-03-29

    Thyroid cancer is the most common endocrine cancer with 1,690 deaths each year. There are four main types of which the papillary and follicular types together account for >90% followed by medullary cancers with 3% to 5% and anaplastic carcinomas making up <3%. Epigenetic events of DNA hypermethylation are emerging as promising molecular targets for cancer detection. Our immediate and long term goal is to identify DNA methylation markers for early detection of thyroid cancer. This pilot study comprised of 21 patients to include 11 papillary thyroid cancers (PTC), 2 follicular thyroid cancers (FTC), 5 normal thyroid cases, and 3 hyperthyroid cases. Aberrant promoter methylation was examined in 24 tumor suppressor genes using the methylation specific multiplex ligation-dependent probe amplification (MS-MLPA) assay and in the NIS gene using methylation-specific PCR (MSP). The frequently methylated genes were CASP8 (17/21), RASSF1 (16/21) and NIS (9/21). In the normal samples, CASP8, RASSF1 and NIS were methylated in 5/5, 4/5 and 1/5 respectively. In the hyperthyroid samples, CASP8, RASSF1 and NIS were methylated in 3/3, 2/3 and 1/3 respectively. In the thyroid cancers, CASP8, RASSF1, and NIS were methylated in 9/13, 10/13, and 7/13 respectively. CASP8, RASSF1 and NIS were also methylated in concurrently present normal thyroid tissue in 3/11, 4/11 and 3/11 matched thyroid cancer cases (matched for presence of both normal thyroid tissue and thyroid cancer), respectively. Our data suggests that aberrant methylation of CASP8, RASSF1, and NIS maybe an early change in thyroid tumorigenesis regardless of cell type.

  10. Quality assurance measures in non-interventional studies: Results of a survey among the members of the Association of Research-Based Pharmaceutical Companies

    Directory of Open Access Journals (Sweden)

    Ruppert, Thorsten

    2008-11-01

    Full Text Available Research into the therapeutic efficacy of a preparation, its safety and tolerability in the human body, as well as its development into a medicinal product is governed by strict legal provisions and regulations such as those stipulated in the German Drug Law (AMG and the German Ordinance for Good Clinical Practice in Trials on Medicinal Products for Human Use (GCP-V. In the post-marketing setting, when drugs are tested under routine conditions and in large numbers of patients, non-interventional studies (NIS, which include Anwendungsbeobachtungen (AWB as the most common form in Germany, have shown to be effective instruments for assessing the safety of a medicinal product and for confirming the results obtained in clinical trials regarding the efficacy of the drug. NIS/AWB studies are not subject to the same strict regulations that govern the development of a medicinal product; in fact they follow recommendations such as those issued by the Federal Higher Authorities and the Expert Committee on Good Epidemiological Practice. Further provisions on NIS/AWB are laid down in the “Codex of the Voluntary Self-regulation for the Pharmaceutical Industry” and the “Common point of view of the Associations of the Pharmaceutical Industry on the assessment of criminality in the collaboration between industry, medical institutions and their staff”. In early 2007, the German Association of Research-Based Pharmaceutical Companies (VFA consolidated the essential elements of these recommendations, supplemented them by new provisions and published the resulting document as „VFA Recommendations for the Improvement of Quality and Transparency of Non-interventional Studies“. Among other initiatives, these recommendations stipulate specific measures for quality assurance in NIS, approximating NIS standards to those applicable to clinical trials. At the same time NIS are being subjected to transparency criteria with regard to the planning, conduct and

  11. Quantum Noether identities for non-local transformations in higher-order derivatives theories

    CERN Document Server

    Li, Z P

    2003-01-01

    Based on the phase-space generating functional of the Green function for a system with a regular/singular higher-order Lagrangian, the quantum canonical Noether identities (NIs) under a local and non-local transformation in phase space have been deduced, respectively. For a singular higher-order Lagrangian, one must use an effective canonical action I sub e sub f sub f sup P in quantum canonical NIs instead of the classical I sup P in classical canonical NIs. The quantum NIs under a local and non-local transformation in configuration space for a gauge-invariant system with a higher-order Lagrangian have also been derived. The above results hold true whether or not the Jacobian of the transformation is equal to unity or not. It has been pointed out that in certain cases the quantum NIs may be converted to conservation laws at the quantum level. This algorithm to derive the quantum conservation laws is significantly different from the quantum first Noether theorem. The applications of our formulation to the Yan...

  12. Nosocomial infections and fever of unknown origin in pediatric hematology/oncology unit: a retrospective annual study.

    Science.gov (United States)

    Al-Tonbary, Youssef A; Soliman, Othman E; Sarhan, Mohammed M; Hegazi, Moustafa A; El-Ashry, Rasha A; El-Sharkawy, Ashraf A; Salama, Osama S; Yahya, Raida

    2011-02-01

    pediatric hematology/oncology patients are faced with an increased risk of nosocomial infections (NIs) that vary in different populations and different institutions with considerable morbidity and mortality. This study was undertaken to assess the frequency and patterns of NIs in 1564 pediatric patients and to determine the prevalence of causative organisms and their antimicrobial sensitivity. a retrospective analysis was made in the patients admitted between January 2007 and January 2008 to the pediatric hematoloy/oncology unit of Mansoura University, Egypt. The 1564 patients showed 2084 admissions and 27 092 inpatient days. The Centers for Disease Control and Prevention criteria were used as a standard definition for NI. the overall rate of NIs in all patients and neutropenic patients was 8.6 and 25.3 per 1000 patient-days respectively. The frequent sites of NIs were blood stream (42.7%), the respiratory system (25.3%), the urinary system (22.2%) and the central nervous system (9.8%), whereas nosocomial fever of unknown origin constituted 52.9% of cases. The incidence of NIs was significantly higher during neutropenic days (Pfever of unknown origin are the most common nosocomial infections in pediatric hematology/oncology patients with a higher risk during neutropenic days. Isolated organisms are multi-drug resistant, predominantly Gram-positive pathogens with a high incidence of methicillin-resistant S. aureus, extended spectrum beta lactamase and vancomycin resistant enterococci organisms.

  13. Determining the Independent Risk Factors and Mortality Rate of Nosocomial Infections in Pediatric Patients.

    Science.gov (United States)

    Aktar, Fesih; Tekin, Recep; Güneş, Ali; Ülgen, Cevat; Tan, İlhan; Ertuğrul, Sabahattin; Köşker, Muhammet; Balık, Hasan; Karabel, Duran; Yolbaş, Ilyas

    2016-01-01

    The objective of this study was to determine the rate, independent risk factors, and outcomes of healthcare-associated infections in pediatric patients. This study was performed between 2011 and 2014 in pediatric clinic and intensive care unit. 86 patients and 86 control subjects were included in the study. Of 86 patients with nosocomial infections (NIs), there were 100 NIs episodes and 90 culture growths. The median age was 32.0 months. The median duration of hospital stay of the patients was 30.0 days. The most frequent pathogens were Coagulase-negative Staphylococcus, Acinetobacter spp., Klebsiella spp., and Candida spp. Unconsciousness, prolonged hospitalization, transfusion, mechanical ventilation, use of central venous catheter, enteral feeding via a nasogastric tube, urinary catheter, and receiving carbapenems and glycopeptides were found to be significantly higher in NIs patients. Multivariate logistic regression analysis showed prolonged hospitalization, neutropenia, and use of central venous catheter and carbapenems as the independent risk factors for NIs. In the univariate analysis, unconsciousness, mechanical ventilation, enteral feeding, use of enteral feeding via a nasogastric tube, H2 receptor blockers, and port and urinary catheter were significantly associated with mortality. In the multiple logistic regression analysis, only mechanical ventilation was found as an independent predictor of mortality in patients with NIs.

  14. Hypoxia-targeted 131I therapy of hepatocellular cancer after systemic mesenchymal stem cell-mediated sodium iodide symporter gene delivery.

    Science.gov (United States)

    Müller, Andrea M; Schmohl, Kathrin A; Knoop, Kerstin; Schug, Christina; Urnauer, Sarah; Hagenhoff, Anna; Clevert, Dirk-André; Ingrisch, Michael; Niess, Hanno; Carlsen, Janette; Zach, Christian; Wagner, Ernst; Bartenstein, Peter; Nelson, Peter J; Spitzweg, Christine

    2016-08-23

    Adoptively transferred mesenchymal stem cells (MSCs) home to solid tumors. Biologic features within the tumor environment can be used to selectively activate transgenes in engineered MSCs after tumor invasion. One of the characteristic features of solid tumors is hypoxia. We evaluated a hypoxia-based imaging and therapy strategy to target expression of the sodium iodide symporter (NIS) gene to experimental hepatocellular carcinoma (HCC) delivered by MSCs.MSCs engineered to express transgenes driven by a hypoxia-responsive promoter showed robust transgene induction under hypoxia as demonstrated by mCherry expression in tumor cell spheroid models, or radioiodide uptake using NIS. Subcutaneous and orthotopic HCC xenograft mouse models revealed significant levels of perchlorate-sensitive NIS-mediated tumoral radioiodide accumulation by tumor-recruited MSCs using 123I-scintigraphy or 124I-positron emission tomography. Functional NIS expression was further confirmed by ex vivo 123I-biodistribution analysis. Administration of a therapeutic dose of 131I in mice treated with NIS-transfected MSCs resulted in delayed tumor growth and reduced tumor perfusion, as shown by contrast-enhanced sonography, and significantly prolonged survival of mice bearing orthotopic HCC tumors. Interestingly, radioiodide uptake into subcutaneous tumors was not sufficient to induce therapeutic effects. Our results demonstrate the potential of using tumor hypoxia-based approaches to drive radioiodide therapy in non-thyroidal tumors.

  15. Determining the Independent Risk Factors and Mortality Rate of Nosocomial Infections in Pediatric Patients

    Directory of Open Access Journals (Sweden)

    Fesih Aktar

    2016-01-01

    Full Text Available The objective of this study was to determine the rate, independent risk factors, and outcomes of healthcare-associated infections in pediatric patients. This study was performed between 2011 and 2014 in pediatric clinic and intensive care unit. 86 patients and 86 control subjects were included in the study. Of 86 patients with nosocomial infections (NIs, there were 100 NIs episodes and 90 culture growths. The median age was 32.0 months. The median duration of hospital stay of the patients was 30.0 days. The most frequent pathogens were Coagulase-negative Staphylococcus, Acinetobacter spp., Klebsiella spp., and Candida spp. Unconsciousness, prolonged hospitalization, transfusion, mechanical ventilation, use of central venous catheter, enteral feeding via a nasogastric tube, urinary catheter, and receiving carbapenems and glycopeptides were found to be significantly higher in NIs patients. Multivariate logistic regression analysis showed prolonged hospitalization, neutropenia, and use of central venous catheter and carbapenems as the independent risk factors for NIs. In the univariate analysis, unconsciousness, mechanical ventilation, enteral feeding, use of enteral feeding via a nasogastric tube, H2 receptor blockers, and port and urinary catheter were significantly associated with mortality. In the multiple logistic regression analysis, only mechanical ventilation was found as an independent predictor of mortality in patients with NIs.

  16. Nitrification inhibitors can increase post-harvest nitrous oxide emissions in an intensive vegetable production system

    Science.gov (United States)

    Scheer, Clemens; Rowlings, David; Firrell, Mary; Deuter, Peter; Morris, Stephen; Riches, David; Porter, Ian; Grace, Peter

    2017-01-01

    To investigate the effect of nitrification inhibitors (NIs) 3,4-dimethylpyrazole phosphate (DMPP) and 3-methylpyrazole 1,2,4-triazole (3MP + TZ), on N2O emissions and yield from a typical vegetable rotation in sub-tropical Australia we monitored soil N2O fluxes continuously over an entire year using an automated greenhouse gas measurement system. The temporal variation of N2O fluxes showed only low emissions over the vegetable cropping phases, but significantly higher emissions were observed post-harvest accounting for 50–70% of the annual emissions. NIs reduced N2O emissions by 20–60% over the vegetable cropping phases; however, this mitigation was offset by elevated N2O emissions from the NIs treatments over the post-harvest fallow period. Annual N2O emissions from the conventional fertiliser, the DMPP treatment, and the 3MP + TZ treatment were 1.3, 1.1 and 1.6 (sem = 0.2) kg-N ha−1 year−1, respectively. This study highlights that the use of NIs in vegetable systems can lead to elevated N2O emissions by storing N in the soil profile that is available to soil microbes during the decomposition of the vegetable residues. Hence the use of NIs in vegetable systems has to be treated carefully and fertiliser rates need to be adjusted to avoid an oversupply of N during the post-harvest phase. PMID:28266551

  17. 人钠/碘同向转运体基因转染胶质瘤细胞介导放射性碘治疗的研究%Transfer of the sodium/iodide symporter gene into gliomas for radioiodine therapy in vitro

    Institute of Scientific and Technical Information of China (English)

    谭建; 李玮; 刘晓华; 肖茜; 贾强; 李宁

    2008-01-01

    Objective The most frequent brain tumors are the gliomas.Glioblastomas arc largely incurable secondary to their rapid,aggressive and diffusely infiltrative growth pattern and hypervascularity.This study,aimed at investigating the possibility of transecting human sodium/iodide symporter(hNIS)gene into human glioma cell lines to facilitate radioactive iodide treatment in vitro.Methods Transecting hNIS gene into human glioma cell lines U251 was performed by recombinant expression plasmids with lipofectamine 2000-plasmid complexes.The hNIS gene cell lines with stable expression(hNIS-U251)were selected through G418 antibiotic constraint.The hNIS-U251 gene cell lines were then evaluated for their biologic functions,including 125I uptake assay.125 I influx-course.125I-efflux-course.131I inhibitory effect on cellular proliferation by 3-(4,5-dimethylthiazol-2-y1)-2,5-diphenylte-trazolium bromide(MTT)assay and flow cytometer.Results We were successful in transecting hNIS gene into human glioma cell lines by recombinant expression plasmids.and were able to obtain hNIS gene cell lines(hNIS-U251)with stable expression.The hNIS-U251 cell lines could intake and bind radioactive iodide by hNIS gene.The uptakes of125 Iwere 117 fold higher in hNIS-U251 cell lines than U251 cell lines[(50 469.88±997.29),(432.92±89.28)counts·min-1,respectively ].And the proliferation index of hNIS-U251 cell lines was lower than U251 cell lines after incubating with 131I.Conclusion The hNIS gene with stable gene expression (hNIS-U251)cell lines could be labeled by 131I with a high efficiency,thereby may function effectively in the treatment of glioma-related brain tumors.%目的 在体外细胞实验中证明转染人钠/碘同向转运体(hNIS)基因介导放射性碘治疗胶质瘤是有效的.方法 以脂质体转染法、用重组质粒将hNIS基因转染至人胶质瘤细胞株U251中.经过G418硫酸盐筛选获得稳定表达hNIS的细胞株(hNIS-U251),然后进行体外摄125I

  18. Investigation of genes involved in nisin production in Enterococcus spp. strains isolated from raw goat milk.

    Science.gov (United States)

    Perin, Luana Martins; Todorov, Svetoslav Dimitrov; Nero, Luís Augusto

    2016-09-01

    Different strains of Lactococcus lactis are capable of producing the bacteriocin nisin. However, genetic transfer mechanisms allow the natural occurrence of genes involved in nisin production in members of other bacterial genera, such as Enterococcus spp. In a previous study, nisA was identified in eight enterococci capable of producing antimicrobial substances. The aim of this study was to verify the presence of genes involved in nisin production in Enterococcus spp. strains, as well as nisin expression. The nisA genes from eight Enterococcus spp. strains were sequenced and the translated amino acid sequences were compared to nisin amino-acid sequences previously described in databases. Although containing nisin structural and maturation related genes, the enterococci strains tested in the present study did not present the immunity related genes (nisFEG and nisI). The translated sequences of nisA showed some point mutations, identical to those presented by Lactococcus strains isolated from goat milk. All enterococci were inhibited by nisin, indicating the absence of immunity and thus that nisin cannot be expressed. This study demonstrated for the first time the natural occurrence of nisin structural genes in Enterococcus strains and highlights the importance of providing evidence of a link between the presence of bacteriocin genes and their expression.

  19. Role of electronic correlation in high-low temperature phase transition of hexagonal nickel sulfide: a comparative density functional theory study with and without correction for on-site Coulomb interaction.

    Science.gov (United States)

    Zhang, Wei-Bing; Li, Jie; Tang, Bi-Yu

    2013-06-28

    The structural, electronic, magnetic, and elastic properties of hexagonal nickel sulfide (NiS) have been investigated comparatively by Density Functional theory (DFT) and DFT plus correction for on-site Coulomb interaction (DFT+U), in which two different exchange correlation functionals local density approximations (LDA) and general gradient approximations (GGA) in the form of Perdew-Burke-Ernzerhof (PBE) are used. Our results indicate LDA and PBE methods predict hexagonal NiS to be a paramagnetic metal whereas LDA(PBE)+U calculations with reasonable on-site Coulomb interaction energy give the antiferromagnetic insulating state of low temperature hexagonal NiS successfully. Meanwhile, compared with LDA(PBE) results, LDA(PBE)+U methods give larger lattice parameters, crystal volume, and shear constant c44, consistent with the experimental picture during high-low temperature phase transition of hexagonal NiS, in which an increase of the shear constant c44 and lattice parameters were found in the low-temperature antiferromagnetic phase. The present DFT and DFT+U calculations provide a reasonable description for the properties of high temperature and low temperature hexagonal NiS respectively, which indicates that electronic correlation is responsible for this high-low temperature phase transition.

  20. Nitrification inhibitors can increase post-harvest nitrous oxide emissions in an intensive vegetable production system.

    Science.gov (United States)

    Scheer, Clemens; Rowlings, David; Firrell, Mary; Deuter, Peter; Morris, Stephen; Riches, David; Porter, Ian; Grace, Peter

    2017-03-07

    To investigate the effect of nitrification inhibitors (NIs) 3,4-dimethylpyrazole phosphate (DMPP) and 3-methylpyrazole 1,2,4-triazole (3MP + TZ), on N2O emissions and yield from a typical vegetable rotation in sub-tropical Australia we monitored soil N2O fluxes continuously over an entire year using an automated greenhouse gas measurement system. The temporal variation of N2O fluxes showed only low emissions over the vegetable cropping phases, but significantly higher emissions were observed post-harvest accounting for 50-70% of the annual emissions. NIs reduced N2O emissions by 20-60% over the vegetable cropping phases; however, this mitigation was offset by elevated N2O emissions from the NIs treatments over the post-harvest fallow period. Annual N2O emissions from the conventional fertiliser, the DMPP treatment, and the 3MP + TZ treatment were 1.3, 1.1 and 1.6 (sem = 0.2) kg-N ha(-1) year(-1), respectively. This study highlights that the use of NIs in vegetable systems can lead to elevated N2O emissions by storing N in the soil profile that is available to soil microbes during the decomposition of the vegetable residues. Hence the use of NIs in vegetable systems has to be treated carefully and fertiliser rates need to be adjusted to avoid an oversupply of N during the post-harvest phase.

  1. Mammary radioiodine accumulation due to functional sodium iodide symporter expression in a benign fibroadenoma.

    Science.gov (United States)

    Berger, F; Unterholzner, S; Diebold, J; Knesewitsch, P; Hahn, K; Spitzweg, C

    2006-11-03

    The sodium iodide symporter (NIS) has been characterized to mediate the active transport of iodide not only in the thyroid gland but also in various non-thyroidal tissues, including lactating mammary gland and the majority of breast cancers, thereby offering the possibility of diagnostic and therapeutic radioiodine application in breast cancer. In this report, we present a 57-year-old patient with multifocal papillary thyroid carcinoma, who showed focal radioiodine accumulation in a lesion in the right breast on a posttherapy (131)I scan following radioiodine therapy. CT and MR-mammography showed a focal solid lesion in the right breast suggestive of a fibroadenoma, which was confirmed by histological examination. Immunostaining of paraffin-embedded tumor tissue sections using a human NIS antibody demonstrated NIS-specific immunoreactivity confined to epithelial cells of mammary ducts. In conclusion, in a thyroid cancer patient we identified a benign fibroadenoma of the breast expressing high levels of functionally active NIS protein as underlying cause of focal mammary radioiodine accumulation on a posttherapy (131)I scan. These data show for the first time that functional NIS expression is not restricted to lactating mammary gland and malignant breast tissue, but can also be detected in benign breast lesions, such as fibroadenomata of the breast.

  2. Nosocomial Infections and Epidemiology of Antibiotic Resistance in Teaching Hospitals in South East of Iran.

    Science.gov (United States)

    Rajabi, Mahboobeh; Abdar, Mohammad Esmaeili; Rafiei, Hossein; Aflatoonia, Mohammad Reza; Abdar, Zahra Esmaeili

    2015-06-25

    Antibiotic resistance as one of the most serious health threats worldwide leading to a high rate of morbidity and mortality. The aim of present study was to examine the prevalence of nosocomial infections (NIs) and pattern of antibiotic resistance in teaching hospitals in Iran. This cross-sectional descriptive study was conducted in a period of one year in three teaching hospitals and all patients with suspected NIs symptoms were chooses. Among these patients who showed antibiotic resistance were included in the study. The samples for clinical test in laboratory were obtained with using standard methods and aseptic technique by trained personnel. Antibiotic susceptibility testing was performed by Kirby-Bauer's disk diffusion method on Muller-Hinton agar (Hi Media, Mumbai, India) in accordance with the standards of the Clinical Laboratory Standards Institute. During one year study, 561 patients with nosocomial infections were recognized and among them 340 patients (60.6%) showed some level of antibiotic resistance. The most common cause of NIs in present study was Acinetobacter and the most type of infection was respiratory system infections (52.7%). The highest resistance rate was against Ciprofloxacin (61.8%) followed by Imipenem (50.3%). Rate of NIs and antibiotics resistance is high in Iranian hospital. So Iranian health ministry should provide guideline and suitable programs for prevention of NIs and antibiotic therapy in hospitals.

  3. Nitrification inhibitors can increase post-harvest nitrous oxide emissions in an intensive vegetable production system

    Science.gov (United States)

    Scheer, Clemens; Rowlings, David; Firrell, Mary; Deuter, Peter; Morris, Stephen; Riches, David; Porter, Ian; Grace, Peter

    2017-03-01

    To investigate the effect of nitrification inhibitors (NIs) 3,4-dimethylpyrazole phosphate (DMPP) and 3-methylpyrazole 1,2,4-triazole (3MP + TZ), on N2O emissions and yield from a typical vegetable rotation in sub-tropical Australia we monitored soil N2O fluxes continuously over an entire year using an automated greenhouse gas measurement system. The temporal variation of N2O fluxes showed only low emissions over the vegetable cropping phases, but significantly higher emissions were observed post-harvest accounting for 50-70% of the annual emissions. NIs reduced N2O emissions by 20-60% over the vegetable cropping phases; however, this mitigation was offset by elevated N2O emissions from the NIs treatments over the post-harvest fallow period. Annual N2O emissions from the conventional fertiliser, the DMPP treatment, and the 3MP + TZ treatment were 1.3, 1.1 and 1.6 (sem = 0.2) kg-N ha-1 year-1, respectively. This study highlights that the use of NIs in vegetable systems can lead to elevated N2O emissions by storing N in the soil profile that is available to soil microbes during the decomposition of the vegetable residues. Hence the use of NIs in vegetable systems has to be treated carefully and fertiliser rates need to be adjusted to avoid an oversupply of N during the post-harvest phase.

  4. Locally placed nanoscale gold islands film within a TiO2 photoanode for enhanced plasmon light absorption in dye sensitized solar cells

    Science.gov (United States)

    Kim, Taeheon; Kumaresan, Yogeenth; Cho, Sung Jun; Lee, Chang-Lyoul; Lee, Heon; Jung, Gun Young

    2016-12-01

    As metal nanostructures demonstrated extraordinary plasmon resonance, their optical characteristics have widely been investigated in photo-electronic applications. However, there has been no clear demonstration on the location effect of plasmonic metal layer within the photoanode on both optical characteristics and photovoltaic performances. In this research, the gold (Au) nano-islands (NIs) film was embedded at different positions within the TiO2 nanoparticulate photoanode in dye-sensitized solar cells (DSSC) to check the effect of plasmon resonance location on the device performance; at the top, in the middle, at the bottom of the TiO2 photoanode, and also at all the three positions. The Au NIs were fabricated by annealing a Au thin film at 550 °C. The DSSC having the Au NIs-embedded TiO2 photoanode exhibited an increase in short circuit currents (Jsc) and power conversion efficiency (PCE) owing to the plasmon resonance absorption. Thus, the PCE was increased from 5.92% (reference: only TiO2 photoanode) to 6.52% when the Au NIs film was solely positioned at the bottom, in the middle or at the top of TiO2 film. When the Au NIs films were placed at all the three positions, the Jsc was increased by 16% compared to the reference cell, and consequently the PCE was further increased to 7.01%.

  5. Republic of Moldova: between the Eropean Union and Commonwealth of Independent States

    Directory of Open Access Journals (Sweden)

    Yuri Josanu

    2012-08-01

    Full Text Available Moldova is the second smallest and the most densely populated of the NIS. It began the arduous task of building a democratic nation and market-based economy as it faced ethnic conflicts and the social hardships accompanying economic and political transformation. The country has pushed ahead with economic policy reform as a model of change among NIS countries. Moldova is also considered one of the top NIS performers in democratic development. Internal political tensions over the pace of reforms have delayed progress in land privatization and fiscal improvement. Underlying all of these issues is the festering problem of Transdniester where ethnic Russians, bolstered by the presence of Russian troops, thus denying Moldova control over significant industrial assets.

  6. Time-course investigation of infection with a low virulent Pasteurella multocida strain in normal and immune-suppressed 12-week-old free-range chickens

    DEFF Research Database (Denmark)

    Mbuthia, P.G.; Njagi, L.W.; Nyaga, P.N.;

    2011-01-01

    Twelve-week-old indigenous chickens, either immune-suppressed using dexamethasone (IS) or non-immune-suppressed (NIS), were challenged with a low virulent strain, Pasteurella multocida strain NCTC 10322(T), and developed clinical signs and pathological lesions typical of chronic fowl cholera. NIS...... birds demonstrated much more severe signs of fowl cholera than IS birds. With few exceptions, signs recorded in IS and NIS birds were of the same types, but significantly milder in the IS birds, indicating that immune suppression does not change the course of infection but rather the severity of signs...... in fowl cholera. P. multocida signals by fluorescent in situ hybridization (FISH) were observed between 1 h and 14 days in the lungs, trachea, air sacs, liver, spleen, bursa of Fabricius and caecal tonsils, while signals from other organs mostly were observed after 24 h. More organs had FISH signals...

  7. Is the National Institute of Silicosis under threat. Peligra el Instituto Nacional de Silicosis

    Energy Technology Data Exchange (ETDEWEB)

    Barral, J.J. (Instituto Nacional de Silicosis (Spain))

    1991-01-01

    The NIS (National Institute of Silicosis) was founded in Asturias some 20 years ago. Since then, approximately 80,000 workers have benefitted from its services. The Institute has deservedly acquired a reputation for the treatment and prevention of pneumoconiosis. However, a growing number of voices are expressing doubt over the future existence of the centre, following its integration into the hospital complex. The unions announce that the NIS must be protected at all costs, while those engaged in this field of industrial health are quick to affirm that the service is being run down without a viable alternative being planned. But is the NIS really under threat For the moment the Institute is being used as a National Reference Centre and it is currently up to the Administration of Mines whether to re-open the establishment or to run it down. 10 figs.

  8. Nickel Sulfide/Graphene/Carbon Nanotube Composites as Electrode Material for the Supercapacitor Application in the Sea Flashing Signal System

    Institute of Scientific and Technical Information of China (English)

    Hailong Chen; Ji Li; Conglai Long; Tong Wei; Guoqing Ning; Jun Yan; Zhuangjun Fan

    2014-01-01

    This work presents NiS/graphene/carbon nanotube (NiS/GNS/CNT) composites as electrode material for the supercapacitor application in sea flashing signal systems. NiS nanosheets were closely anchored on the conductive GNS-CNT networks. As a result, the NiS/GNS/CNT electrode showed a high specific capacitance of 2 377 F·g-1 at 2 mV·s-1 and good cycling stability compared with the pure NiS (1 599 F·g-1 ). The enhanced electrochemical performances are attributed to the synergetic effect between the conductive carbon and the pseudo-capacitive NiS. The high performance supercapacitor may provide application in the sea flashing signal system.

  9. Early detection of eukaryotic communities from marine biofilm using high-throughput sequencing: an assessment of different sampling devices.

    Science.gov (United States)

    Pochon, Xavier; Zaiko, Anastasija; Hopkins, Grant A; Banks, Jonathan C; Wood, Susanna A

    2015-01-01

    Marine biofilms are precursors for colonization by larger fouling organisms, including non-indigenous species (NIS). In this study, high-throughput sequencing (HTS) of 18S rRNA metabarcodes was used to investigate four sampling methods (modified syringe, sterilized sponge, underwater tape and sterilized swab) for characterizing eukaryotic communities in marine biofilms. Perspex™ plates were sampled in and out of water. DNA collected with tape did not amplify. Otherwise, there were no statistical differences in communities among the remaining three sampling devices or between the two environments. Sterilized sponges are recommended for ease of use underwater. In-depth HTS analysis identified diverse eukaryotic communities, dominated by Metazoa and Chromoalveolata. Among the latter, diatoms (Bacillariophyceae) were particularly abundant (33% of reads assigned to Chromalveolata). The NIS Ciona savignyi was detected in all samples. The application of HTS in marine biofilm surveillance could facilitate early detection of NIS, improving the probability of successful eradication.

  10. Ecological risk assessment conceptual model formulation for nonindigenous species.

    Science.gov (United States)

    Landis, Wayne G

    2004-08-01

    This article addresses the application of ecological risk assessment at the regional scale to the prediction of impacts due to invasive or nonindigenous species (NIS). The first section describes risk assessment, the decision-making process, and introduces regional risk assessment. A general conceptual model for the risk assessment of NIS is then presented based upon the regional risk assessment approach. Two diverse examples of the application of this approach are presented. The first example is based upon the dynamics of introduced plasmids into bacteria populations. The second example is the application risk assessment approach to the invasion of a coastal marine site of Cherry Point, Washington, USA by the European green crab. The lessons learned from the two examples demonstrate that assessment of the risks of invasion of NIS will have to incorporate not only the characteristics of the invasive species, but also the other stresses and impacts affecting the region of interest.

  11. Concentrations of neonicotinoid insecticides in honey, pollen and honey bees (Apis mellifera L.) in central Saskatchewan, Canada.

    Science.gov (United States)

    Codling, Garry; Al Naggar, Yahya; Giesy, John P; Robertson, Albert J

    2016-02-01

    Neonicotinoid insecticides (NIs) and their transformation products were detected in honey, pollen and honey bees, (Apis mellifera) from hives located within 30 km of the City of Saskatoon, Saskatchewan, Canada. Clothianidin and thiamethoxam were the most frequently detected NIs, found in 68 and 75% of honey samples at mean concentrations of 8.2 and 17.2 ng g(-1) wet mass, (wm), respectively. Clothianidin was also found in >50% of samples of bees and pollen. Concentrations of clothianidin in bees exceed the LD50 in 2 of 28 samples, while for other NIs concentrations were typically 10-100-fold less than the oral LD50. Imidaclorpid was detected in ∼30% of samples of honey, but only 5% of pollen and concentrations were honey and pollen by bees over winter, during which worker bees live longer than in summer, suggested that, in some hives, consumption of honey and pollen during over-wintering might have adverse effects on bees.

  12. Attitudes toward Physician-Nurse Collaboration in Pediatric Workers and Undergraduate Medical/Nursing Students

    Directory of Open Access Journals (Sweden)

    Yong Wang

    2015-01-01

    Full Text Available The purpose of this study was to compare the attitudes of pediatric workers and undergraduate medical/nursing students toward collaboration. Attitude toward collaboration was measured using an adaptation of the Jefferson Scale of Attitude toward Physician-Nurse Collaboration. The 656 questionnaires were gathered from pediatrician, pediatric interns, and medical students (PIS and pediatric nurses, nursing interns, and nursing students (NIS. Results showed a statistically significant difference in the total mean scores in attitudes towards collaboration with NIS scoring higher. Among the participants of PIS, the pediatricians obtained the highest mean scores, while, among the participants of NIS, the pediatric nurses got higher mean scores than nursing interns. It is desirable that medical and nurse schools should include interprofessional education in their curriculum to increase the understanding of the complementary roles of physicians and nurses and to encourage establishment of an interdependent relationship between them.

  13. Effect of Cytokine on the Expression of Sodium Iodide Symporter Gene in Breast Cancer Cell

    Institute of Scientific and Technical Information of China (English)

    JIAYue; LIUChao; TANGWei; LIUCui-ping; QINYou-wen; YUANQing-xing; LIQian; MAOXiao-dong; DIFu-song

    2004-01-01

    To investigate the effect of cytokines (TNF-α, IFN-γ and IL-6) on the expression of sodi-um-iodide symporter(NIS) gene in breast cancer cell (MCF-7). Methods:The breast cancer cell was cultureds with negative control culture or cultures with different concentrations of cytokines for 72 h. NIS germ mRNA in breast cancer cells cultured was determined by reverse transcriptase-polymerase chain reaction(RT-PCR). Results:Expression of sodium-iodide symporter mRNA can be found decreasing along with increasing the concentration of cytokine dose-depen-dently. Conchzs/on ~ Cytokine may play a role in iodide-uptake modulating in breast cancer cells by their effect on NIS germ expression.

  14. Insertion of the human sodium iodide symporter to facilitate deep tissue imaging does not alter oncolytic or replication capability of a novel vaccinia virus

    Directory of Open Access Journals (Sweden)

    Mittra Arjun

    2011-03-01

    Full Text Available Abstract Introduction Oncolytic viruses show promise for treating cancer. However, to assess therapeutic efficacy and potential toxicity, a noninvasive imaging modality is needed. This study aimed to determine if insertion of the human sodium iodide symporter (hNIS cDNA as a marker for non-invasive imaging of virotherapy alters the replication and oncolytic capability of a novel vaccinia virus, GLV-1h153. Methods GLV-1h153 was modified from parental vaccinia virus GLV-1h68 to carry hNIS via homologous recombination. GLV-1h153 was tested against human pancreatic cancer cell line PANC-1 for replication via viral plaque assays and flow cytometry. Expression and transportation of hNIS in infected cells was evaluated using Westernblot and immunofluorescence. Intracellular uptake of radioiodide was assessed using radiouptake assays. Viral cytotoxicity and tumor regression of treated PANC-1tumor xenografts in nude mice was also determined. Finally, tumor radiouptake in xenografts was assessed via positron emission tomography (PET utilizing carrier-free 124I radiotracer. Results GLV-1h153 infected, replicated within, and killed PANC-1 cells as efficiently as GLV-1h68. GLV-1h153 provided dose-dependent levels of hNIS expression in infected cells. Immunofluorescence detected transport of the protein to the cell membrane prior to cell lysis, enhancing hNIS-specific radiouptake (P In vivo, GLV-1h153 was as safe and effective as GLV-1h68 in regressing pancreatic cancer xenografts (P 124I-PET. Conclusion Insertion of the hNIS gene does not hinder replication or oncolytic capability of GLV-1h153, rendering this novel virus a promising new candidate for the noninvasive imaging and tracking of oncolytic viral therapy.

  15. Comparative analysis of perioperative complications between a multicenter prospective cervical deformity database and the Nationwide Inpatient Sample database.

    Science.gov (United States)

    Passias, Peter G; Horn, Samantha R; Jalai, Cyrus M; Poorman, Gregory; Bono, Olivia J; Ramchandran, Subaraman; Smith, Justin S; Scheer, Justin K; Sciubba, Daniel M; Hamilton, D Kojo; Mundis, Gregory; Oh, Cheongeun; Klineberg, Eric O; Lafage, Virginie; Shaffrey, Christopher I; Ames, Christopher P

    2017-05-17

    Complication rates for adult cervical deformity are poorly characterized given the complexity and heterogeneity of cases. To compare perioperative complication rates following adult cervical deformity corrective surgery between a prospective multicenter database for patients with cervical deformity (PCD) and the Nationwide Inpatient Sample (NIS). Retrospective review of prospective databases. A total of 11,501 adult patients with cervical deformity (11,379 patients from the NIS and 122 patients from the PCD database). Perioperative medical and surgical complications. The NIS was queried (2001-2013) for cervical deformity discharges for patients ≥18 years undergoing cervical fusions using International Classification of Disease, Ninth Revision (ICD-9) coding. Patients ≥18 years from the PCD database (2013-2015) were selected. Equivalent complications were identified and rates were compared. Bonferroni correction (pdatabases. A total of 11,379 patients from the NIS database and 122 patiens from the PCD database were identified. Patients from the PCD database were older (62.49 vs. 55.15, pdatabase. The PCD database had an increased risk of reporting overall complications than the NIS (odds ratio: 2.81, confidence interval: 1.81-4.38). Only device-related complications were greater in the NIS (7.1% vs. 1.1%, p=.007). Patients from the PCD database displayed higher rates of the following complications: peripheral vascular (0.8% vs. 0.1%, p=.001), gastrointestinal (GI) (2.5% vs. 0.2%, pdatabases (p>.004). Based on surgical approach, the PCD reported higher GI and neurologic complication rates for combined anterior-posterior procedures (pdatabase revealed higher overall and individual complication rates and higher data granularity. The nationwide database may underestimate complications of patients with adult cervical deformity (ACD) particularly in regard to perioperative surgical details owing to coding and deformity generalizations. The surgeon-maintained database

  16. A luminescent nisin biosensor

    Science.gov (United States)

    Immonen, Nina; Karp, Matti

    2006-02-01

    Nisin is a lantibiotic, an antibacterial peptide produced by certain Lactococcus lactis strains that kills or inhibits the growth of other bacteria. Nisin is widely used as a food preservative, and its long-time use suggests that it can be generally regarded as safe. We have developed a method for determining the amount of nisin in food samples that is based on luminescent biosensor bacteria. Bacterial luciferase operon luxABCDE was inserted into plasmid pNZ8048, and the construct was transformed by electroporation into Lc. lactis strain NZ9800, whose ability to produce nisin has been erased by deletion of the gene nisA. The operon luxABCDE has been modified to be functional in gram-positive bacteria to confer a bioluminescent phenotype without the requirement of adding an exogenous substrate. In the plasmid pNZ8048, the operon was placed under control of the nisin-inducible nisA promoter. The chromosomal nisRK genes of Lc. lactis NZ9800 allow it to sense nisin in the environment and relay this signal via signal transduction proteins NisK and NisR to initiate transcription from nisA promoter. In the case of our sensor bacteria, this leads to production of luciferase and, thus, luminescence that can be directly measured from living bacteria. Luminescence can be detected as early as within minutes of induction. The nisin assay described here provides a detection limit in the sub-picogram level per ml, and a linear area between 1 - 1000 pg/ml. The sensitivity of this assay exceeds the performance of all previously published methods.

  17. Nisin Z Production by Lactococcus lactis subsp. cremoris WA2-67 of Aquatic Origin as a Defense Mechanism to Protect Rainbow Trout (Oncorhynchus mykiss, Walbaum) Against Lactococcus garvieae.

    Science.gov (United States)

    Araújo, Carlos; Muñoz-Atienza, Estefanía; Pérez-Sánchez, Tania; Poeta, Patrícia; Igrejas, Gilberto; Hernández, Pablo E; Herranz, Carmen; Ruiz-Zarzuela, Imanol; Cintas, Luis M

    2015-12-01

    Probiotics represent an alternative to chemotherapy and vaccination to control fish diseases, including lactococcosis caused by Lactococcus garvieae. The aims of this study were (i) to determine the in vitro probiotic properties of three bacteriocinogenic Lactococcus lactis subsp. cremoris of aquatic origin, (ii) to evaluate in vivo the ability of L. cremoris WA2-67 to protect rainbow trout (Oncorhynchus mykiss, Walbaum) against infection by L. garvieae, and (iii) to demonstrate the role of nisin Z (NisZ) production as an anti-infective mechanism. The three L. cremoris strains survived in freshwater at 18 °C for 7 days, withstood exposure to pH 3.0 and 10 % (v/v) rainbow trout bile, and showed different cell surface hydrophobicity (37.93-58.52 %). The wild-type NisZ-producer L. cremoris WA2-67 and its non-bacteriocinogenic mutant L. cremoris WA2-67 ∆nisZ were administered orally (10(6) CFU/g) to rainbow trout for 21 days and, subsequently, fish were challenged with L. garvieae CLG4 by the cohabitation method. The fish fed with the bacteriocinogenic strain L. cremoris WA2-67 reduced significantly (p < 0.01) the mortality (20 %) compared to the fish treated with its non-bacteriocinogenic knockout isogenic mutant (50 %) and the control (72.5 %). We demonstrated the effectiveness of L. cremoris WA2-67 to protect rainbow trout against infection with the invasive pathogen L. garvieae and the relevance of NisZ production as an anti-infective mechanism. This is the first report demonstrating the effective in vivo role of LAB bacteriocin (NisZ) production as a mechanism to protect fish against bacterial infection. Our results suggest that the wild-type NisZ-producer strain L. cremoris WA2-67 could be used in fish farming to prevent lactococcosis in rainbow trout.

  18. Factors influencing densities of non-indigenous species in the ballast water of ships arriving at ports in Puget Sound, Washington, United States

    Science.gov (United States)

    Cordell, J.R.; Lawrence, D.J.; Ferm, N.C.; Tear, L.M.; Smith, S.S.; Herwig, R.P.

    2009-01-01

    Oceanographic characteristics and the presence of international shipping in Puget Sound, Washington, USA contribute to its vulnerability to non-indigenous species (NIS) invasions. To evaluate NIS arriving in ballast water, zooplankton was sampled in 380 ballast tanks of ships after they entered Puget Sound. Taxa were classified into a higher risk group of coastal organisms (including known NIS), and a lower risk group of largely oceanic species. Most ships reported conducting mid-ocean ballast water exchange (BWE). However, despite state regulations requiring BWE, and apparent compliance by ship operators, most sampled tanks from both transpacific and coastal routes had coastal zooplankton densities exceeding internationally proposed discharge standards. BWE efficiency models and controlled before-and-after BWE experiments indicate that BWE consistently removes most coastal zooplankton. However, this study found that although the empty-refill method of BWE significantly reduced coastal plankton compared with un-exchanged tanks, the flow-through method did not, and in either case remaining coastal plankton densities presented appreciable risks of introducing NIS. Densities of high risk taxa were consistently and significantly higher from US domestic trips dominated by tank ships carrying ballast water from California, and lower in samples from trans-Pacific trips dominated by container ships and bulk carriers with ballast from Asia. These findings are probably a result of the dense and diverse NIS assemblages present in California and other US west coast estuaries and the comparatively short transit times between them and Puget Sound. While it appears that BWE can effectively replace NIS with less risky ocean species, new reporting, verification, and operational procedures may be necessary to enhance BWE efficacy. In the long-term, the introduction of ballast water treatment technologies may be required to significantly reduce the discharge of risky organisms from

  19. The electrosmog phenomenon. Effects of low-frequency EM fields on human health; Das Phaenomen `Elektrosmog`. Wirkung niederfrequenter EM-Felder auf den Menschen

    Energy Technology Data Exchange (ETDEWEB)

    Schierz, C. [Inst fuer Hygiene und Arbeitsphysiologie, ETH-Zentrum, Zuerich (Switzerland); Krueger, H. [Inst fuer Hygiene und Arbeitsphysiologie, ETH-Zentrum, Zuerich (Switzerland)

    1996-12-13

    In spite of the close link between electricity and quality of life, there have been misgivings during the past few years concerning the potential harmful effects of electromagnetic fields. From the scientific point of view, there are four different categories of problems: 1. The daily exposure level; 2. Biological effects of electromagnetic fields; 3. Public opinion and acceptance; 4. Establishment of limiting values on the basis of scientific findings. (orig.) [Deutsch] Trotz der engen Verbindung von Lebensqualitaet und elektrischer Energie breitet sich in den letzten Jahren ein Gefuehl der Betroffenheit ueber vorhandene oder moegliche Schaedigungen durch elektromagnetische Felder aus. Aus wissenschaftlicher Sicht stellen sich vier Problemfelder: Wie hoch ist die taegliche Exposition? Was ist ueber biologische Wirkungen elektromagnetischer Felder bekannt? Welche Bedeutung hat eine Attributierung fuer die Bewertung in der Oeffentlichkeit? Welche Bedeutung kommt der Erforschung der biologischen Wirkung elektromagnetischer Felder bei der Festlegung von Grenzwerten zu? (orig.)

  20. Materials and process engineering projects for the Sandia National Laboratories/Newly Independent States Industrial Partnering Program. Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    Zanner, F.J.; Moffatt, W.C.

    1995-07-01

    In July, 1994, a team of materials specialists from Sandia and US. Industry traveled to Russia and the Ukraine to select and fund projects in materials and process technology in support of the Newly Independent States/Industrial Partnering Program (NIS/IPP). All of the projects are collaborations with scientists and Engineers at NIS Institutes. Each project is scheduled to last one year, and the deliverables are formatted to supply US. Industry with information which will enable rational decisions to be made regarding the commercial value of these technologies. This work is an unedited interim compilation of the deliverables received to date.

  1. A Trial of Nursing Cost Accounting using Nursing Practice Data on a Hospital Information System.

    Science.gov (United States)

    Miyahira, Akiko; Tada, Kazuko; Ishima, Masatoshi; Nagao, Hidenori; Miyamoto, Tadashi; Nakagawa, Yoshiaki; Takemura, Tadamasa

    2015-01-01

    Hospital administration is very important and many hospitals carry out activity-based costing under comprehensive medicine. However, nursing cost is unclear, because nursing practice is expanding both quantitatively and qualitatively and it is difficult to grasp all nursing practices, and nursing cost is calculated in many cases comprehensively. On the other hand, a nursing information system (NIS) is implemented in many hospitals in Japan and we are beginning to get nursing practical data. In this paper, we propose a nursing cost accounting model and we simulate a cost by nursing contribution using NIS data.

  2. Design of Fault Tolerant Network Interfaces for NoCs

    DEFF Research Database (Denmark)

    Fiorin, Leandro; Micconi, Laura; Sami, Mariagiovanna

    2011-01-01

    Networks-on-Chip (NoCs) appeared as a strategy to deal with the communication requirements of complex IP-based System-on-Chips. As the complexity of designs increases and the technology scales down into the deep-submicron domain, the probability of malfunctions and failures in the NoC components...... increases. This paper focuses on the study and evaluation of techniques for increasing reliability and resilience of Network Interfaces (NIs). NIs act as interfaces between IP cores and the communication infrastructure; a faulty behavior in them could affect therefore the overall system. In this work, we...

  3. National Counterterrorism Center: 2007 Report on Terrorism

    Science.gov (United States)

    2008-04-30

    shooting (for instance, improvised explosive...16,000 Ira q Afg ha nis tan Pa kis tan Ind ia Th ail an d So ma lia Su da n Ch ad Co lom bia Sr i L an ka Ph ilip pin es Alg eri a De mo cra tic R ep...ilip pin es Ga za St rip Afg ha nis tan Co ng o, De mo cra tic R ep ub lic Pa kis tan Ind ia Ch ad Nig eri a Co lom bia Nig er Su da n Ne the

  4. Feasibility of sodium/iodide symporter gene as a new imaging reporter gene: comparison with HSV1-tk

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Jae Hoon; Chung, June-Key; Lee, Yong Jin; Kim, Kwang Il [Department of Nuclear Medicine, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-dong, 110-744, Chongno-gu, Seoul (Korea); Department of Tumor Biology, Cancer Research Institute, Seoul National University College of Medicine, Seoul (Korea); Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University College of Medicine, Seoul (Korea); Kang, Joo Hyun; Jeong, Jae Min; Lee, Dong Soo [Department of Nuclear Medicine, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-dong, 110-744, Chongno-gu, Seoul (Korea); Kim, Chul Woo [Department of Pathology, Cancer Research Institute, Seoul National University College of Medicine, Seoul (Korea); Lee, Myung Chul [Department of Nuclear Medicine, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-dong, 110-744, Chongno-gu, Seoul (Korea)

    2004-03-01

    Positron emission tomography (PET) imaging reporter genes, such as HSV1-tk and D{sub 2} receptor genes, make it possible to visualise gene expression non-invasively and repetitively in vivo. However, these systems require the synthesis of complicated substrates and the availability of expensive PET equipment. Expression of the sodium/iodide symporter (NIS) gene can be easily monitored with radioiodines and technetium-99m using a gamma camera. To evaluate the possibility of using NIS as an imaging reporter gene, we compared its characteristics with those of the conventional HSV1-tk gene. The CM cell line was made by transfecting the HSV1-tk gene into CT-26 (mouse colon carcinoma cell line). The CTN and CMN cell lines were then made by transfecting the NIS gene into CT-26 and CM. We measured the uptake of iodine-125 iodovinyldeoxyuridine ([{sup 125}I]IVDU) and {sup 125}I to evaluate the expression of the HSV1-tk and NIS genes, respectively. Each cell line was injected into four flank sites in Balb/c mice. The biodistribution study was performed after intravenously injecting [{sup 125}I]IVDU and {sup 131}I, and {sup 131}I scintigraphy was performed for the evaluation of NIS expression. In vitro studies indicated that CTN and CMN had 40- to 79-fold and 150- to 256-fold higher uptake of {sup 125}I than CT-26 and CM, respectively. Furthermore, CM and CMN showed 57- to 69-fold higher uptake of [{sup 125}I]IVDU than CT-26 and CTN. NIS gene expression and {sup 125}I accumulation were found to be directly correlated (R{sup 2}=0.923), as were HSV1-tk gene expression and [{sup 125}I]IVDU accumulation (R{sup 2}=0.956). Calculated signal per unit NIS and HSV1-tk mRNA expression was 23,240{+-}3,755 cpm and 34,039{+-}5,346 cpm, respectively. In vivo study indicated that CTN and CMN had 2.3- and 5.8-fold higher uptake of {sup 131}I than CT-26 and CM, and 1.8- and 3.5-fold higher uptake of [{sup 125}I]IVDU than CT-26 and CTN. Scintigraphy using {sup 131}I easily visualised CTN and

  5. Materials and process engineering projects for the Sandia National Laboratories/Newly Independent States Industrial Partnering Program. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Zanner, F.J.; Moffatt, W.C.

    1995-07-01

    In July, 1994, a team of materials specialists from Sandia and U S Industry traveled to Russia and the Ukraine to select and fund projects in materials and process technology in support of the Newly Independent States/Industrial Partnering Program (NIS/IPP). All of the projects are collaborations with scientists and Engineers at NIS Institutes. Each project is scheduled to last one year, and the deliverables are formatted to supply US Industry with information which will enable rational decisions to be made regarding the commercial value of these technologies. This work is an unedited interim compilation of the deliverables received to date.

  6. Data acquisition, event building and signal reconstruction for Compton camera imaging

    OpenAIRE

    Nurdan, Kivanc

    2006-01-01

    Nurdan, Kıvanç Die Compton-Camera ist ein neues Detektorsystem zur bildlichen Darstellung von radioaktiven Markierungssubstanzen im Bereich der Gammastrahlung, das prinzipiell eine besonders gute Ortsauflösung und hohe Empfindlichkeit liefern kann. Die ist von grosser Bedeutung für die moderne bio-medizinische Forschung oder für darauf basierende diagnostische Verfahren. Dafür ist ein neues Konzept einer software-basierten Koinzidenzmessung entwickelt worden, das auf den b...

  7. "Der Islam" in Deutschland. Transformationsprozesse muslimischer Religiosität in der Diaspora

    OpenAIRE

    Noormann, Harry

    2006-01-01

    Der Autor stellt vor dem Hintergrund einer religionswissenschaftlichen Migrationsforschung die historisch gewachsene Bedeutung des Islams in Deutschland dar. Dabei kommen Möglichkeiten und Grenzen von Transkulturalität in den Blick. (DIPF/Orig.) The author presents the historically growing importance of the Islam in Germany with the background of a migration research on religious science. Thereby, chances and limits of transculturality come into focus. (DIPF/Orig.)

  8. Post-Adoption hedonistischer Informationssysteme

    OpenAIRE

    Pannicke, Danny

    2013-01-01

    Die parallele Printausgabe ist im Universitätsverlag der TU Berlin erschienen: ISBN 978-3-7983-2497-8; ISSN 2197-8522 Mit dem zunehmenden Einsatz vernetzter elektronischer Geräte im persönlichen Bereich und im Haushalt wächst in den letzten Jahren die Bedeutung hedonistischer Informationssysteme. Dabei kann grundsätzlich zwischen interaktiven Unterhaltungssystemen und dualen Systemen des Lifestyle Computing unterschieden werden. Aus Sicht der Wirtschaftsinformatik liegen bisher vergleichsw...

  9. Wirtschaftliche Stellung deutscher Unternehmen in Chile: Ergebnisse einer empirischen Analyse

    OpenAIRE

    Kassai, László B.

    2014-01-01

    Die Abschätzung der wirtschaftlichen Bedeutung deutscher Unternehmen in Chile anhand der Auswertung von 14 schriftlichen Interviews mit deutschen Tochtergesellschaften im Jahre 1987 ist der Inhalt dieses Beitrages. Die Einordnung erfolgt vor dem Hintergrund sowohl der wirtschaftlichen Situation der ganzen Region (Lateinamerika) als auch der industriellen Entwicklung in Chile bis 1987. Die Analyse kommt zum Schluß, daß die im Durchschnitt lang ansässigen Unternehmen a) eine rege Innovations...

  10. Augsburger Volkskundliche Nachrichten: 02/2014

    OpenAIRE

    Kronenbitter, Günther

    2014-01-01

    Inhalt: Dr. Phillip, Michael: Humanistische Diätetik im Fürstenspiegel des Konrad Herresbach - Göser, Andrea: Happy Meal?! Die gemeinsame Mahlzeit und ihre soziale Bedeutung - Würtemberger, David: Burger-Boom - Hillesheim, Sebastian: Slow Food: Massenbewegung oder Genießer-Club? - Weise, Stephanie: Containern: Essen aus der Mülltonne. Lässt sich eine Umsetzung des Phänomens auch mit dem Augsburger Müll realisieren? - Ausstellungen - Rezensionen

  11. Der Neokortex der Säugetiere : Evolution und Funktion

    OpenAIRE

    Kern, Alexander

    2012-01-01

    In der Neurobiologie nimmt die Untersuchung der Großhirnrinde (Neokortex) eine gewisse Sonderstellung ein, weil das Verständnis dieser hierarchisch übergeordneten Region für die Analyse bzw. Rekonstruktion der Hirnfunktionen insgesamt von entscheidender Bedeutung ist. Dabei macht Folgendes die bedeutungsvolle Stellung des Neokortex aus: seine späte stammesgeschichtliche und ontogenetische Entwicklung, welche bei mehreren Säugetiergruppen mit einer ungewöhnlichen Massenzunahme und Plastizit...

  12. Analyse und Bewertung von Naturgefahren als Grundlage für ein nachhaltiges Naturgefahrenmanagement in Gebirgssystemen SO-Kasachstans am Beispiel des Ile-Alatau

    OpenAIRE

    2007-01-01

    Den Fragen der Erarbeitung des Naturgefahrenmanagements in Gebirgsystemen SO-Kasachstans und in den Ländern des Zentralasiens insgesamt wurde bisher keine gebührende Aufmerksamkeit zuteil. Die Naturkatastrophen der letzten Jahrzehnte sowie die Erfahrung mit Maßnahmen zum Schutz des Ile-Alatau vor Naturgefahren haben gezeigt, dass die Lösung dieser Probleme für die weitere nachhaltige Entwicklung dieser Region von erstrangiger Bedeutung ist. In dieser Arbeit wurde vom Autor umfangreiches Ma...

  13. Wuchsdepressionen von Gehölzarten im Baumschulbereich

    OpenAIRE

    Spethmann, Wolfgang; Wilstermann, Maike

    2003-01-01

    Im Rahmen des Projektes wurden wissenschaftliche und populäre Veröffentlichungen zum Themenbereich Wachstumsdepressionen, Nachbauprobleme, Bodenmüdigkeit und Allelopathie recherchiert und ausgewertet. Es wurden Praktiker, Berater und Wissenschaftler befragt und die jeweiligen Ergebnisse in 3 Workshops diskutiert. Rosaceae sind von den Nachbauproblemen am stärksten betroffen. Die größte wirtschaftliche Bedeutung haben dabei Rose und Apfel. Mit großer Sicherheit kann ein Zusammenhang zwischen e...

  14. Evolutionäre Strategien und multitome Optimierung

    OpenAIRE

    Rosé, Helge

    1998-01-01

    Für die erfolgreiche Lösung eines Optimierungsproblems ist die Wahl der verwendeten Suchstrategie von entscheidender Bedeutung. Die vorliegende Arbeit untersucht die Kriterien dieser Wahl. Dabei stellen sich drei grundlegende Fragen: Welche Strategien der Optimierung eines gegebenen Problems existieren überhaupt, und was für Eigenschaften besitzen sie? Wodurch wird der Charakter eines Optimierungsproblems bestimmt, und gibt es Klassen ähnlicher Probleme? Besteht eine Verbindung zwischen den E...

  15. Time and space in social theory

    OpenAIRE

    1980-01-01

    Der Verfasser kritisiert zwei zentrale Aspekte des 'orthodoxen Konsenses' in der Soziologie, Funktionalismus und Evolutionstheorien. Er zeigt, daß funktionalistischen Theorien eine falsche Trennung von Statik und Dynamik zugrundeliegt, daß sie die Bedeutung vernunftgesteuerten Handelns vernachlässigen und daß der Begriff 'Systembedürfnisse' keinerlei Erklärungskraft besitzt. Die Kritik der Evolutionstheorien bezieht sich hauptsächlich auf den zentralen Begriff der 'Adaption' an Umweltbedingun...

  16. Anfangen, sich die Welt anders vorzustellen Beginning to Imagine the World Differently

    OpenAIRE

    Sabine Fuchs

    2006-01-01

    Der Sammelband Butler Matters bezeugt Judith Butlers außerordentliche Bedeutung für feministische und queere Studien und Forschung. In elf Beiträgen wird Butlers (frühes) Werk von Gender Trouble und Bodies That Matter über Excitable Speech bis zu The Psychic Life of Power betrachtet und sein weit reichender Einfluss quer durch die wissenschaftlichen Disziplinen nachgewiesen. Dargestellt werden auch die kontroverse Rezeption von Butlers Werk sowie die politischen Wirkungen von Butlers Denken. ...

  17. Farbkodierte objektangepasste Streifenprojektion für die schnelle 2D- und 3D-Qualitätsprüfung

    OpenAIRE

    Haist, Tobias; Tiziani, Hans J.

    2002-01-01

    Die Kontrolle von Werkstücken hinsichtlich ihrer dreidimensionalen Geometrie und ihrer Oberflächencharakteristik ist von entscheidender Bedeutung für die automatisierte industrielle Produktion. Vorgestellt wird ein schnelles und robustes Einzelbildverfahren das es gestattet, gleichzeitig die Topographie zu kontrollieren und ein Videobild des Werkstückes zu generieren. Hierzu wird eine objektangepasste Streifenprojektion mit einer farbkodierten Maske verwendet. Zur Detektion können preiswer...

  18. 3D-Erfassung und Objektrekonstruktion mittels Streifenprojektion

    OpenAIRE

    Gühring, Jens

    2002-01-01

    Die dreidimensionale Digitalisierung von Objekten mit Hilfe von optischen Verfahren hat in den vergangenen Jahren große Bedeutung gewonnen. Infolge der intensiven Forschung ist weltweit eine ganze Reihe von Systemen entwickelt worden, welche in so unterschiedlichen Bereichen wie industrieller Qualitätskontrolelle, Reverse Engineering, virtueller Realität und Medizin eingesetzt werden. Fortschritte in der Sensortechnik und der Verarbeitung der Messdaten haben die Erfassung nahezu beliebig komp...

  19. Hochattraktiv oder nur nicht unattraktiv: Was zählt bei der Partnerwahl?

    OpenAIRE

    Cyrus,Kerstin

    2014-01-01

    Dass der physischen Attraktivität eine hohe Bedeutung beigemessen wird und Menschen viel Zeit und Mühe darin investieren, ihr äußeres Erscheinungsbild aufzuwerten, ist epochen- und kulturübergreifend zu beobachten. Evolutionspsychologische Forschungsarbeiten widmen sich vor allem der Fragestellung, welche Rolle physische Attraktivität im Partnerwahlkontext spielt. Der Versuch der Evolutionspsychologie, Antworten auf die Frage zu finden, was physische Attraktivität ausmacht und welc...

  20. Selbstkonzept und Angst-Leistung-Relation in Eignungsuntersuchungen der Agentur für Arbeit: Eine Studie zum Defizit-Modell der Testangst

    OpenAIRE

    Rohweder, Norbert

    2002-01-01

    Ausgehend vom Defizit-Modell der Testangst, wonach eine negative Angst-Leistung-Relation aus erlebter Inkompetenz während der Testbearbeitung resultiert, wird die Bedeutung des Selbstkonzepts untersucht. Angenommen wird, dass Besorgtheit als maßgebliche Komponente der Testangstreaktion dann prägnanter vorhergesagt werden kann, wenn neben der Testleistung auch das Selbstkonzept der Begabung erhoben wird. Im Rahmen von psychologischen Berufseignungsuntersuchungen wurden im Zusammenhang mit eine...

  1. Internetgestützte Ideenfindungsprozesse mit webSCW

    OpenAIRE

    Krause, Dirk

    2016-01-01

    aus der Einleitung: "Die Bedeutung der Arbeit in Gruppen nimmt wegen der Globalisierung und steigender Aufgabenkomplexität in Wirtschaft und Verwaltung sowie der deshalb erforderlichen problemrelevanten Kooperation der am Lösungsprozess beteiligten Mitarbeiter ständig zu. Außerdem ergeben verteilte Standorte erhöhte Anforderungen an die Kommunikation und Koordination dieser Gruppen. Durch den erreichten hohen Vernetzungsgrad der Arbeitsplätze bieten ander...

  2. Investigations on the significance of the gastrointestinal flora for the immune system of chickens

    OpenAIRE

    Elsayed, Nasser

    2004-01-01

    7. Zusammenfassung Untersuchungen zur Bedeutung der Magen-Darm-Flora auf das Immunsystem von Hühnern Nasser Ali Abou Hashem Elsayed Instiut für Bakteriologie und Mykologie, Veterinärmedizinische Fakultät, Universität Leipzig Leipzig, Juli, 2002 (128 Seiten, 60 Abbildungen, 21 Tabellen und 227 Referenzen) Viele komplexe bakterielle Kontrollmechanismen der Darmmikroflora sind am Ausschluss pathogener Keime beteiligt. Dysregulationen im gastrointestinalen Ökosystem können den schützenden Effekt ...

  3. Die Ferse schmerzt: Behandlung des M. triceps surae bei Patienten mit Fasciitis plantaris : Ein systematisches Literaturreview

    OpenAIRE

    Brunner, Melanie

    2015-01-01

    Darstellung des Themas: Die Dehnung des M. triceps surae bei Patienten mit Fasciitis plantaris wird in der Literatur als begleitende Intervention empfohlen. Dies lässt einen Zusammenhang zwischen den Plantarflexoren und den Fersenschmerzen vermuten, weshalb die Untersuchung von weiteren Behandlungsmethoden am M. triceps surae von Bedeutung ist. Ziel: Das Ziel dieser Arbeit war, eine Aussage über die Effektivität von verschiedenen Behandlungsmethoden des M. triceps surae bei Patienten mit F...

  4. Fluchen und Flamen, um ein Mann zu sein? Die Verknüpfung von Geschlecht und Sprache durch Vorurteile The Manliness of Swearing and Flaming-On The Role of Stereoptypes in Research on Gender and Language

    OpenAIRE

    Nicola Döring

    2001-01-01

    Die hier besprochene Monographie der Linguistin Anja Gottburgsen beschäftigt sich theoretisch und empirisch mit sprachbezogenen Geschlechterstereotypen, also mit unseren Vorstellungen darüber, ob und wie Männer und Frauen jeweils in spezifischer und distinkter Weise sprachlich kommunizieren. Im Theorieteil der Arbeit wird der aktuelle Stand der soziolinguistischen und sozialpsychologischen Diskussion zu Geschlecht, Sprachverhalten und Stereotypisierung kritisch referiert und die Bedeutung von...

  5. Competitive Intelligence : Aufbau einer Informationsbasis und Entscheidungssystematik zur Definition strategischer Zielmärkte

    OpenAIRE

    Maffenbeier, Sina

    2010-01-01

    Im Rahmen der Globalisierung und des daraus resultierenden Wettbewerbs ist es für ein Unternehmen von zentraler Bedeutung, Wissen über die Wettbewerbssituation zu erhalten. Nicht nur zur Erschließung neuer Märkte, sondern auch zur Sicherung der Unternehmensexistenz ist eine Wettbewerbsanalyse unabdingbar. Konkurrenz- bzw. Wettbewerbsforschung wird überwiegend als „Competitive Intelligence“ bezeichnet. In diesem Sinne beschäftigt sich die vorliegende Bachelorarbeit mit einem Bereich von Compet...

  6. El sentido de la familia: una construcción con las tramas de vida de tres generaciones

    OpenAIRE

    Salas, Leonor Mora

    2008-01-01

    Gegenstand meines Beitrages ist die Frage, wie Familien Sinn und Bedeutung des Begriffes "Familie" konstruieren. Die hier vorgestellte Theorie geht auf die Analyse von vier früheren qualitativen Untersuchungen zurück, in denen individuelle Interviews mit Mitgliedern von insgesamt 14 Familien unterschiedlicher sozioökonomischer Herkunft in Caracas, Venezuela, durchgeführt wurden. In jedem einzelnen Fall wurden Mitglieder aus drei unterschiedlichen Generationen interviewt, in deren Erzählungen ...

  7. Impulsbasierte Dynamiksimulation von Mehrkörpersystemen in der virtuellen Realität

    OpenAIRE

    Bender, Jan

    2007-01-01

    Die dynamische Simulation gewinnt im Bereich der virtuellen Realität immer mehr an Bedeutung. Sie ist ein wichtiges Hilfsmittel, um den Grad der Immersion des Benutzers in eine virtuelle Welt zu erhöhen. In diesem Anwendungsbereich ist die Geschwindigkeit des verwendeten Simulationsverfahrens entscheidend. Weitere Anforderungen an das Verfahren sind unter anderem Genauigkeit, Stabilität und eine einfache Implementierung. In dieser Arbeit wird ein neues impulsbasiertes Verfahren für die dynami...

  8. Erster Deutscher IPv6 Gipfel

    OpenAIRE

    Meinel, Christoph; Sack, Harald; Bross, Justus

    2009-01-01

    Inhalt: KOMMUNIQUÉ GRUßWORT PROGRAMM HINTERGRÜNDE UND FAKTEN REFERENTEN: BIOGRAFIE & VOTRAGSZUSAMMENFASSUNG 1.) DER ERSTE DEUTSCHE IPV6 GIPFEL AM HASSO PLATTNER INSTITUT IN POTSDAM - PROF. DR. CHRISTOPH MEINEL - VIVIANE REDING 2.) IPV6, ITS TIME HAS COME - VINTON CERF 3.) DIE BEDEUTUNG VON IPV6 FÜR DIE ÖFFENTLICHE VERWALTUNG IN DEUTSCHLAND - MARTIN SCHALLBRUCH 4.) TOWARDS THE FUTURE OF THE INTERNET - PROF. DR. LUTZ HEUSER 5.) IPV6 STRATEGY & DEPLOYMENT STATUS IN JAPAN - HIROSHI MIYATA 6.) IPV...

  9. Einführung eines neuen perioperativen Verfahrens in der Visceralchirurgie (Fast Track Chirurgie) : eine Untersuchung an 101 konsekutiven Patienten

    OpenAIRE

    Ulrich, Jürgen

    2007-01-01

    Beschleunigte postoperative Rehabilitation gewinnt zunehmend an Bedeutung. Es wurden 101 Patientnen nach elektiven Eingriffen am Magen-Darm-Trakt prospektiv untersucht. Das Konzept umfasste: Erfassung des Ernährungszustandes, Verzicht auf präoperative Darmspülung, Essen bis zum OP-Tag, Trinken klarer Flüssigkeit bis 2 Stunden vor Narkoseeinleitung. Nach Möglichkeit Verzicht auf Drainagen, Magensonden und Dauerkatheter, intra- und postoperative epidurale Anästhesie. Beginn der Ernä...

  10. Review: Thomas Kühn (2004). Berufsbiografie und Familiengründung. Biografiegestaltung junger Erwachsener nach Abschluss der Berufsausbildung

    OpenAIRE

    Große, Stefanie

    2005-01-01

    Thomas KÜHN beschäftigt sich in seinem Buch, das die Veröffentlichung seiner Dissertation darstellt, mit Orientierungen und Handlungsstrategien junger Erwachsener zwischen Berufsbiografie und Familiengründung unter den Bedingungen grundlegender gesamtgesellschaftlicher Veränderungsprozesse. Sein Forschungsinteresse zielt darauf ab, der Bedeutung von Planungsprozessen zur Familiengründung nachzugehen. Er möchte einen Beitrag zum Verständnis zunehmender Kinderlosigkeit und des Phänomens der Sta...

  11. Protektive in vitro Wirkung mitochondrialer Entkoppler auf die Apoptose in Leukämiezellinien

    OpenAIRE

    Pogrebniak, Alexei

    2003-01-01

    Den überwiegend in den Mitochondrien lokalisierten Membranproteinen der Bcl-2-Familie wird eine besonders kritische Bedeutung beim Schutz der Zelle gegen den apoptotischen Zelltod beigemessen. Der genaue Wirkungsmechanismus dieser Proteine ist bis dato unbekannt. Sie sind aber in der Lage, in der mitochondrialen Membran Kanäle zu bilden und dadurch den funktionellen Veränderungen in den Mitochondrien im Verlauf der Apoptose sowie ihrer Schwellung entgegenzuwirken. Eine Störung des mitochondri...

  12. Lernen im Museum: Die Rolle kognitiver Konflikte als Stimuli für Neugier, Elaboration und konzeptuelle Veränderung

    OpenAIRE

    2010-01-01

    Museen und Ausstellungen sind informelle Lernumgebungen, die zunehmend an Bedeutung gewinnen. Untersuchungen zum Lernen im Museum zeigen jedoch, dass die Auseinandersetzung mit den dargestellten Themen und Inhalten häufig oberflächlich stattfindet. Ergebnisse und Befunde aus der Lehr-/Lernforschung belegen, dass kognitive Konflikte eine intensive Auseinandersetzung mit einem Gegenstand auslösen und fördern können. Allerdings wurde bisher nicht untersucht, inwiefern sich dieser Ansatz auch ...

  13. Differentielle Regulation von Schlüsselgenen der gastralen Säuresekretion durch Gastrin, oxidativen Stress und Helicobacter pylori

    OpenAIRE

    Höcker, Michael

    2002-01-01

    Die transkriptionelle Aktivierung des HDC Gens sowie des Chromogranin A Gens in ECL-Zellen der Magenmucosa repräsentiert einen zentralen Mechanismus der Säureregulation durch Gastrin und scheint ausserdem Bedeutung für die Pathogenese der gastroduodenalen Ulkuskrankheit zu haben. Unsere Untersuchungen identifizieren erstmals die molekularen Mechanismen der Gastrin-abhängigen Regulation beider Gene und definieren die beteiligten Transkriptionsfaktoren, regulatorischen DNA-Elemente und intrazel...

  14. Rehabilitation im Alter

    OpenAIRE

    Meinck, Matthias

    2003-01-01

    Internationale kontrollierte Studien haben die Wirksamkeit geriatrischer Rehabilitation grundsätzlich bestätigt. Die Ergebnisse sind jedoch nur eingeschränkt auf Deutschland übertragbar. Geriatrische Rehabilitation gewinnt in Deutschland aufgrund der demographischen Veränderungen an Bedeutung. Der Vorrang ambulanter vor stationärer Leistungserbringung wurde schon vor einigen Jahren gesetzlich verankert. Der Anteil ambulanter Reha-Maßnahmen an den geriatrischen Reha-Leistungen ist jedoch gerin...

  15. Kenneth Gergen: Die "Oldstream"-Psychologie wird verschwinden wie die Dinosaurier!

    OpenAIRE

    Mattes, Peter; Schraube, Ernst

    2004-01-01

    Das Gespräch beleuchtet das Wissenschaftsverständnis des sozialen Konstruktionismus, Theorie – Methodik – Praxis, im Spannungsfeld zur traditionellen Psychologie. Der erste Teil handelt von Orten und Formen sozialkonstruktionistischen Denkens und es werden Grenzen des herkömmlichen psychologischen Wissenschaftsverständnisses erörtert. Danach geht es um die Frage einer spezifisch sozialkonstruktionistischen Methodologie und um die Bedeutung sozialer Beziehungen für ein angemessenes Verständnis...

  16. Entwicklung eines Ansatzes zur proaktiven Identifikation und Bestandsplanung von langsamdrehenden Materialien

    OpenAIRE

    Hoppenheit, Steffi; Günthner, Willibald A.

    2014-01-01

    Dem Bestandsmanagement wird in Unternehmen eine stetig steigende Bedeutung beigemessen. Die Möglichkeit, durch ein effizientes Bestandsmanagement Kosten zu reduzieren, ist für viele Unternehmen im Hinblick auf einen langfristigen Unternehmenserfolg wichtig. Im Fokus des Bestandsmanagements stehen oft schnelldrehende Materialien, die sich durch geringe Reichweiten und hohe Lagerumschläge auszeichnen. Das Potenzial eines systematischen Managements von langsamdrehenden Materialien wurde bisher n...

  17. Physostigmin in der Aufwachphase des Hundes nach zwei l-Methadon-Narkoseprotokollen

    OpenAIRE

    2010-01-01

    Störungen der Aufwachphase sind sowohl in der Human-, als auch Veterinäranästhesiologie von Bedeutung. So kann eine verlängerte, aber auch eine unruhige exzitatorische Aufwachphase zusätzlichen intensivmedizinischen, zeitlichen und finanziellen Aufwand bedeuten. Eine Vielzahl von metabolischen und neuropathologischen, aber auch pharmakologischen Insulten werden insbesondere beim Menschen als Ursachen derartiger Aufwachstörungen beschrieben. Unter anderem scheint auch ein zentra...

  18. A methodical approach for non-destructive estimation of plant pigments by means of remission spectroscopy applied in fruit and vegetable analyses

    OpenAIRE

    Pflanz, Michael

    2014-01-01

    Anbaubegleitende spektral-optische Analysen direkt an der Pflanze haben zunehmend Bedeutung für die gartenbauliche Produktion. Veränderungen individueller Pflanzeninhaltsstoffe können mit Hilfe optischer Sensoren unmittelbar und beliebig oft erfasst werden, wodurch Pflanzenreaktionen auf veränderte Umgebungs- und Kulturbedingungen instrumentell messbar sind. Im Konzept eines Präzisionsgartenbau könnten diese zusätzlichen Informationen adaptiven Kulturmaßnahmen dienen und zur effizienten Nutzu...

  19. Modelle und Methoden für die Bestandsauslegung in Heijunka-nivellierten Supply Chains

    OpenAIRE

    Veit, Martin B.

    2010-01-01

    In dieser Arbeit werden analytische Bestandsmodelle für die Heijunka-Nivellierung unter Berücksichtigung schwankender Nachfrage- und Produktionsprozesse entwickelt. Dies ist in der Praxis von größerer Bedeutung, als die bisherigen wissenschaftlichen Modelle mit dem Ziel einer möglichst gleichmäßigen Produktionssequenz. Es werden Fragestellungen beantwortet, die bei der Auslegung der Nivellierung in der Industrie immer wieder auftreten, wie z.B. die Auslegung bei saisonalem Nachfrageve...

  20. Einfluss der Bitterstoffe des Hopfens auf das Wirtswahlverhalten von Phorodon humuli (Schrank), Homoptera, Aphididae

    OpenAIRE

    Kryvynets, Oleg; Walker, Frank; Zebitz, Claus Paul Walter

    2008-01-01

    Erkenntnisse über das Wirt-Parasit-Verhältnis zwischen Hopfen Humulus lupulus L. und Hopfenblattlaus Phorodon humuli (Schrank) sind von entscheidender Bedeutung für die Selektion blattlausresistenter Sorten. Die Besiedelung des Wirts durch Blattläuse wird durch in den Pflanzen befindliche Substanzen erheblich beeinflusst (Nault & Styer 1972; Leath & al. 1974; Klingauf & al. 1978; Kendall & al. 1980; Singh 1980; Powell & al. 1999; Campo & al. 2003). Die in dieser Hinsicht wichtigsten Bestandte...