WorldWideScience

Sample records for na ich podatnosc

  1. Orientacje socjo-biograficzne młodych Polek na podstawie ich wyborów życiowych dokonanych i deklarowanych

    OpenAIRE

    Czarnota, Wanda

    2014-01-01

    Wanda Czarnota Rozprawa doktorska „Orientacje socjo-biograficzne młodych Polek na podstawie ich wyborów życiowych dokonanych i deklarowanych” Rozprawa składa się z dziewięciu rozdziałów rozmieszczonych w czterech częściach. Część I jest wprowadzeniem do problematyki badań. Rozdział pierwszy dotyczy kategorii „kobieta” – „kobiecość” i zawiera przegląd wybranych fragmentów koncepcji antropologicznych, filozoficznych, psychologicznych i socjologicznych na temat podmiotu „kobieta/kobie...

  2. Patient survey (ICH CAHPS)

    Data.gov (United States)

    U.S. Department of Health & Human Services — In-Center Hemodialysis Facilites Patient evaluations from the In-Center Hemodialysis Consumer Assessment of Healthcare Providers and Systems (ICH-CAHPS) Survey. The...

  3. Redefinícia mólu – pozadie zmien v SI sústave a ich vplyv na vzdelávanie

    Directory of Open Access Journals (Sweden)

    Romana Schubertová

    2015-12-01

    Full Text Available Predkladaný príspevok prepája aktuálnu diskusiu o redefinícii základných jednotiek SI sústavy s vyučovaním chémie. Plánovaná definícia mólu má byť založená na presnom stanovení Avogadrovej konštanty. Problémy, ktoré sú spojené s takýmto definovaním mólu, vychádzajú však aj zo samotnej histórie veličiny látkové množstvo. Jedným zo základných problémov tohto charakteru je, že látkové množstvo je spomedzi základných veličín jedinou diskontinuálnou veličinou, ktorej jednotka mól nebola zavedená na základe vlastností prírody, ale na základe ľudskej dohody. Je teda otázne či je mól zaradený medzi základné jednotky SI sústavy logicky správne. Aj z tohto dôvodu je veličina látkové množstvo zaujímavá taktiež z didaktického hľadiska, ktoré je v príspevku diskutované.

  4. Patient survey (ICH-CAHPS) - State

    Data.gov (United States)

    U.S. Department of Health & Human Services — State averages for ICH-CAHPS Survey measures. The ICH-CAHPS Survey is a national, standardized survey of in-center hemodialysis patients about their experiences with...

  5. Patient survey (ICH-CAHPS) - National

    Data.gov (United States)

    U.S. Department of Health & Human Services — The national average for ICH-CAHPS Survey measures. The ICH-CAHPS Survey is a national, standardized survey of in-center hemodialysis patients about their...

  6. Ich spreche Deutsch: A User's Report

    Science.gov (United States)

    Glassar, Sheila

    1969-01-01

    The textbook under discussion, "Ich spreche Deutsch" by Heinz Griesbach and Dora Schulz (London-Harlow: Longmans-Hueber, 1966), is intended to be a one-year introduction to German, particularly for less academic pupils and students. (FWB)

  7. Ich spreche Deutsch: A User's Report

    Science.gov (United States)

    Glassar, Sheila

    1969-01-01

    The textbook under discussion, "Ich spreche Deutsch" by Heinz Griesbach and Dora Schulz (London-Harlow: Longmans-Hueber, 1966), is intended to be a one-year introduction to German, particularly for less academic pupils and students. (FWB)

  8. Surgical options in ICH including decompressive craniectomy.

    Science.gov (United States)

    Mitchell, Patrick; Gregson, Barbara A; Vindlacheruvu, Raghu R; Mendelow, A David

    2007-10-15

    Intracerebral haemorrhage (ICH) accounts for 15 to 20% of strokes. The condition carries a higher morbidity and mortality than occlusive stroke. Despite considerable research effort, no therapeutic modality either medical or surgical has emerged with clear evidence of benefit other than in rare aneurysmal cases. Intracerebral haemorrhages can be divided into those that arise from pre-existing macroscopic vascular lesions - so called "ictohaemorrhagic lesions", and those that do not; the latter being the commoner. Most of the research that has been done on the benefits of surgery has been in this latter group. Trial data available to date precludes a major benefit from surgical evacuation in a large proportion of cases however there are hypotheses of benefit still under investigation, specifically superficial lobar ICH treated by open surgical evacuation, deeper ICH treated with minimally invasive surgical techniques, and decompressive craniectomy. When an ICH arises from an ictohaemorrhagic lesion, therapy has two goals: to treat the effects of the acute haemorrhage and to prevent a recurrence. Three modalities are available for treating lesions to prevent recurrence: stereotactic radiosurgery, endovascular embolisation, and open surgical resection. As with ICH without an underlying lesion there is no evidence to support surgical removal of the haemorrhage in most cases. An important exception is ICHs arising from intracranial aneurysms where there is good evidence to support evacuation of the haematoma as well as repair of the aneurysm.

  9. THE INFLUENCE OF FLOOR QUALITY ON DAIRY COW BEHAVIOUR AND THEIR BODY CLEANLINESS VPLYV KVALITY PODLAHY NA SPRÁVANIE DOJNÍC A ICH ČISTOTU POVRCHU TELA

    Directory of Open Access Journals (Sweden)

    Emília KUŠNÍROVÁ

    2012-03-01

    Full Text Available The aim of this study was to evaluate the influence of floor quality on the behaviour and cleanliness of the diary cow‘s body. The analysis results show that cows housed in the section with the separated manure solids spent more time lying (41.47% and also laid less in the corridor manure (0.91% than the cows in the section with separated manure solids and the rubber mats where they were laying generally less (35.71%, they spent more time lying in the corridor manure (1.55% and in terms of preference of lying area the cows clearly preferred the separated manure solids (25.8%. Based on observations we can say that cows housed in sections of slurry solid phase were cleaner (average 6.13 points than cows in the section with the rubber and a separated manure (averagely 7.28 points. Nowadays the free housing systems with different types of litter and boxes are frequently used, while the proper littering influences the lying preferences of an animal. In practice, for the dairy cows the deepened lying boxes littered with natural materials such as sawdust, shavings, straw, dried manure and sand boxes or elevated boxes covered with a synthetic material, mattresses or mats are used.Cieľom práce bolo zhodnotiť vplyv kvality podlahy na správanie a čistotu povrchu tela dojníc. Z analýzy výsledkov vyplýva, že dojnice ustajnené v sekcii so separovaným kalom hnojovice venovali ležaniu väčšiu časť (41,47% a ležali aj menej v hnojnej chodbe (0,91% ako dojnice v sekcii so separovaným kalom hnojovice aj gumenými matracmi, kde dojnice celkovo menej ležali (35,71%, viac času ležali v hnojnej chodbe (1,55% a z hľadiska uprednostňovania ležoviska ležali jednoznačne viac na separovanom kale hnojovice (25,8%. Na základe pozorovaní možno povedať, že dojnice ustajnené v sekciách so separovaným kalom hnojovice boli čistejšie (priemerne 6,13 bodov ako dojnice v sekcii so separovaným kalom hnojovice aj gumou (priemerne 7,28 bodov. V s

  10. Enabling ICH Q10 Implementation--Part 1. Striving for Excellence by Embracing ICH Q8 and ICH Q9.

    Science.gov (United States)

    Calnan, Nuala; O'Donnell, Kevin; Greene, Anne

    2013-01-01

    This article is the first in a series of articles that will focus on understanding the implementation essentials necessary to deliver operational excellence through a International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Q10-based pharmaceutical quality system (PQS). The authors examine why, despite the fact that the ICH Q10 guideline has been with us since 2008, the transformation of the traditional Quality Management Systems QMS in use within the pharmaceutical industry is a work in progress for only a few forward-thinking organisations. Unfortunately, this transformation remains a mere aspiration for the majority of organisations. We explore the apparent lack of progress by the pharmaceutical sector in adopting six sigma and related quality management techniques to ensure the availability of high-quality medicines worldwide. The authors propose that the desired progress can be delivered through two key shifts in our current practices; by embodying the principles of operational excellence in every aspect of our business and by learning how to unlock the scientific and tacit knowledge within our organisations. It has been ten years since The Wall Street Journal revealed the pharmaceutical industry's "little secret" comparing the perceived level of manufacturing expertise in the industry as lagging far behind those of potato-chip and laundry-soap makers. Would you consider the quality and manufacturing strategies in place today in your organisation to be more efficient and scientifically based than those of 2003? If so, what evidence exists for you to draw any conclusion regarding enhanced performance? Do your current practices drive innovation and facilitate continual improvement and if so, how? Ultimately, can you confidently affirm that patient-related risks associated with the product(s) manufactured by your organisation have been reduced due to the quality assurance program now applied

  11. CHARAKTERYSTYKA HELIOSTATÓW I ICH ZASTOSOWANIE W HELIOELEKTROWNIACH

    Directory of Open Access Journals (Sweden)

    Paweł WAJSS

    Full Text Available Rozwój energetyki słonecznej związany jest z powstawaniem coraz to nowych konstrukcji maksymalizującej wykorzystanie promieniowania słonecznego. Jednym z kierunków jest wysokotemperaturowa konwersja promieniowania na ciepło. Wtedy, z termodynamicznego punktu widzenia otwierają się nam możliwości np. na generację energii elektrycznej. Konwersja wysokotemperaturowa wymaga jednak koncentracji promieniowania słonecznego. Sposobów koncentracji jest wiele, jednak w artykule skupiono się na koncentracji w układzie pole heliostatów- wieża słoneczna. System taki ma szereg zalet w porównaniu do pojedynczych układów koncentrujących, m.in. możliwe jest budowanie pojedynczej elektrowni. Zasadniczym elementem jest tutaj heliostat. Artykuł definiuje pojęcie heliostatu, przedstawia zasadę jego działania oraz przeznaczenie w helioelektrowniach typu wieżowego. Dokonany został podział urządzeń na podgrupy w zależności od technologii w nich zastosowanych. Zaprezentowane zostały poszczególne elementy budowy heliostatów oraz czynniki, które pośrednio lub bezpośrednio wpływają na ich typ, wielkość oraz cenę. Przedstawiono problematykę rentowności przed jaką stoi dziś rynek helioelektrowni oraz stopień istotności jaki stanowi pole heliostatów dla budżetu całej inwestycji. Wymieniono szczegółowe parametry jakie winny spełniać tego typu urządzenia, z wyodrębnieniem trzech grup: wymagania operacyjne, optyczne oraz wytrzymałościowe. Zaprezentowano szczegółowo trzy przykładowe, znacząco różniące co do zasady działania oraz skali, rozwiązania i sparametryzowano je w formie tabelarycznej.

  12. Idiopathic Chondrolysis of the Hip ( ICH: Report of three Cases

    Directory of Open Access Journals (Sweden)

    C Dechosilpa

    2014-11-01

    Full Text Available Idiopathic Chondrolysis of the Hip (ICH is a rare condition, occurring mostly in black female adolescence. It is characterized by the rapidly progressive destruction of articular cartilage in the hip joint resulting in premature degeneration and subsequent joint arthrosis. We report three cases of ICH: a 13-year old boy presented with left knee pain, an 11-year old girl with right hip pain and a 12-year old girl with right thigh pain. All of them had the same characteristic radiographic findings. The initial treatment was started conservatively. Surgical treatment was performed in one patient in order to confirm diagnosis and correct deformity.

  13. Wie ich mich mit dem äthiopischen Regime anlegte

    DEFF Research Database (Denmark)

    Hagmann, Tobias

    2016-01-01

    Als Forscher und Kritiker der äthiopischen Politik habe ich viel über das Verhältnis gelernt, in dem Wahrheit und Macht, aber auch Moral und persönliche Interessen zueinander stehen. In den Niederungen der Realpolitik wird mit harten Bandagen um die Deutungshoheit gekämpft wird. Auch Wissenschafter...

  14. Parasitism by Ich enhanced susceptibility of tilapia to Flavobacterium columnare

    Science.gov (United States)

    In aquaculture systems, fish are commonly infected by two or more pathogens. Bacterium Flavobacterium columnare and parasite Ichthyophthirius multifiliis (Ich) are two common pathogens of cultured fish and result in heavy economic losses for aquaculture. There is no published information available ...

  15. I-Ching, Chinese Thinking Mode And Chinese Language

    Institute of Scientific and Technical Information of China (English)

    何婧媛

    2013-01-01

      I-Ching regards human-being as an integral part of nature and stresses the relative complimentary of the two opposing principles of nature, Yin and Yang. Therefore, under the influence of I-Ching, the Chinese thinking mode is different from the west-erners’. The Chinese thinking pattern is holistic, dynamic and abstract, but lacking logic and inference. The Chinese tend to express their ideas succinctly in a few simple remarks. Consequently Chinese is a concise and comprehensive language full of hint and ambiguity.

  16. Engineering design and fabrication of ICH antenna on KSTAR

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Y.D.; Hong, B.G.; Hwang, C.K. [Korea Atomic Energy Research Institute, Taejon (Korea)

    1999-08-01

    Engineering design of 6MW ICH(Ion Cyclotron Heating) system for the plasma heating and current drive in KSTAR (Korea Superconducting Tokamak Advanced Research) tokamak is carried out and a proto-type antenna is domestically fabricated. The proto-type antenna is installed on RF test chamber, and its mutual coupling and vacuum impedance will be measured. Furthermore, high voltage and current behavior under no-plasma load conditions will be studied using 100 kW of 30 MHz RF power. A vacuum feedthrough is designed and fabricated using two ceramic cylinder, which has power rating of 1.5 MW and pulse length of 300 sec. Its RF characteristics will be tested using 100 kW RF transmitter. 19 refs., 46 figs., 8 tabs. (Author)

  17. Średnie sezonowe i roczne amplitudy dobowe temperatury powietrza i trendy ich zmian w Arktyce w okresie 1951-1990

    OpenAIRE

    Przybylak, Rajmund

    1996-01-01

    Przeprowadzone w ostatnich kilku latach badania zmienności z roku na rok średnich sezonowych i rocznych dobowych temperatur minimalnych i maksymalnych wykazały ich asymetryczny przebieg (Karl i in. 1991, 1993, 1994). Nad większością badanych obszarów znacznie silniejszy wzrost posiadają temperatury minimalne niż maksymalne. Karl i in. (1993) stwierdzili, że na 50% obszaru półkuli północnej i na 37% obszarów lądowych całej kuli ziemskiej wzrost dobowych temperatur minimalnych jest około 3-krot...

  18. Hydrogen inhalation ameliorated mast cell mediated brain injury after ICH in mice

    Science.gov (United States)

    Manaenko, Anatol; Lekic, Tim; Ma, Qingyi; Zhang, John H.; Tang, Jiping

    2012-01-01

    OBJECTIVE Hydrogen inhalation was neuroprotective in several brain injury models. Its mechanisms are believed to be related to anti-oxidative stress. We investigated the potential neurovascular protective effect of hydrogen inhalation especially effect on mast cell activation in a mouse model of intracerebral hemorrhage (ICH). DESIGN Controlled in vivo laboratory study. SETTING Animal research laboratory SUBJECTS 171, 8 weeks old male CD-1 mice were used. INTERVENTIONS Collagenase-induced ICH model in 8 weeks old, male, CD-1 mice was used. Hydrogen was administrated via spontaneous inhalation. The blood-brain barrier (BBB) permeability and neurological deficits were investigated at 24 and 72 hours after ICH. Mast cell activation was evaluated by Western blot and immuno-staining. The effects of hydrogen inhalation on mast cell activation were confirmed in an autologous blood injection model ICH. MEASURMENT AND MAIN RESULTS At 24 and 72 hours post-ICH, animals showed BBB disruption, brain edema, neurological deficits, accompanied with phosphorylation of Lyn kinase and release of tryptase, indicating mast cell activation. Hydrogen treatment diminished phosphorylation of Lyn kinase and release of tryptase, decreased accumulation and degranulation of mast cells, attenuated BBB disruption and improved neurobehavioral function. CONCLUSION Activation of mast cells following ICH contributed to increase of BBB permeability and brain edema. Hydrogen inhalation preserved BBB disruption by prevention of mast cell activation after ICH. PMID:23388512

  19. Role of PDGF-D and PDGFR-β in neuroinflammation in experimental ICH mice model☆

    Science.gov (United States)

    Yang, Peng; Manaenko, Anatol; Xu, Feng; Miao, Liyan; Wang, Gaiqing; Hu, Xuezhen; Guo, Zhen-Ni; Hu, Qin; Hartman, Richard E.; Pearce, William J.; Obenaus, Andre; Zhang, John H.; Chen, Gang; Tang, Jiping

    2016-01-01

    Objective Inflammation plays a key role in the pathophysiological processes after intracerebral hemorrhage (ICH). Post-ICH macrophages infiltrate the brain and release pro-inflammatory factors (tumor necrosis factor-α), amplifying microglial activation and neutrophil infiltration. Platelet-derived growth factor receptor-β (PDGFR-β) is expressed on macrophages and it's activation induces the recruitment of macrophages. Platelet-derived growth factor-D (PDGF-D) is an agonist with a significantly higher affinity to the PDGFR-β compared to another isoform of the receptor. In this study, we investigated the role of PDGF-D in the pro-inflammatory response after ICH in mice. Methods A blood injection model of ICH was used in eight-week old male CD1 mice (weight 30 g). Some mice received an injection of plasmin or PDGF-D. Gleevec, a PDGFR inhibitor, was administered at 1, 3 or 6 h post-ICH. Plasmin was administered with or without PDGF-D siRNAs mixture or scramble siRNA. A plasmin-antagonist, ε-Aminocaproic acid (EACA), was co-administrated with the blood. The effects of ICH and treatment on the brain injury and post-ICH inflammation were investigated. Results ICH resulted in the overexpression of PDGF-D, associated with the infiltration of macrophages. PDGFR-inhibition decreased ICH-induced brain injury, attenuating macrophage and neutrophil infiltration, reducing microglial activation and TNF-α production. Administration of recombinant PDGF-D induced TNF-α production, and PDGFR-inhibition attenuated it. A plasmin-antagonist suppressed PDGFR-β activation and microglial activation. Plasmin increased PDGF-D expression, and PDGF-D inhibition reduced neutrophil infiltration. Conclusion ICH-induced PDGF-D accumulation contributed to post-ICH inflammation via PDGFR activation and enhanced macrophage infiltration. The inhibition of PDGFR had an anti-inflammatory effect. Plasmin is a possible upstream effector of PDGF-D. The targeting of PDGF-D may provide a novel way to

  20. Evidence that cyclophosphamide can to induce exchanges in the sister chromatids (ICH) through secondary injuries; Evidencia de que la ciclofosfamida puede inducir intercambios en las cromatidas hermanas (ICH) a traves de lesiones secundarias

    Energy Technology Data Exchange (ETDEWEB)

    Morales R, P.; Rodriguez R, R. [Instituto Nacional de Investigaciones nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1997-07-01

    By means of the use of destination protocol of ICH inductive injuries (DLI-ICH), it was studied if interchanges in the sister chromatids (ICH) induced by cyclophosphamide (CP), in the second post-treatment division (ICH-2) are produced by secondary injuries or by fresh injuries. For discard between these possibilities it was administered CP at different periods before of the first post-treatment division, taking as reference the administered time for high dose of bromodeoxyuridine (BrdU ) which was approximately at the beginning of this division. The ICH frequencies that occur in the first, the second and the third synthesis stages (S) were determined. It was observed that when the administered CP was four hours before BrdU , the ICH frequencies of the second and the third S were reduced. The frequency of the first ICH increased lightly in relation to those of the normal protocol (0.5 h before BrdU ) and that the supplying of CP six hours before caused almost a total reduction of ICH of second and third S and an important increment of ICH of first S.This was interpreted as evidence that the ICH-2 are product of secondary injuries. (Author)

  1. Entre mundos, gestos e palavras: memória corporal, literatura e história no Ballet-Drama K'iche'rab'inal Achi

    OpenAIRE

    Antonio Augusto Horta Liza

    2006-01-01

    Esta pesquisa objetiva a realização de um estudo inter e multidisciplinar da obra Rab'inal Achi, considerada, até o presente momento, o principal remanescente da arte dramática mesoamericana. O Rab'inal Achi é reconhecido como patrimônio cultural da Guatemala, destacando-se, sobretudo,na condição de relíquia viva da comunidade K'iche-achi, assentada no município de Rab'inal (Departamento da Baixa Vera Paz). Devido à longevidade e ao valor cultural deste objeto-tema de estudo, fez-se necessári...

  2. Revision of the ICH guideline on detection of toxicity to reproduction for medicinal products: SWOT analysis.

    Science.gov (United States)

    Barrow, Paul

    2016-09-01

    SWOT analysis was used to gain insights and perspectives into the revision of the ICH S5(R2) guideline on detection of toxicity to reproduction for medicinal products. The current ICH guideline was rapidly adopted worldwide and has an excellent safety record for more than 20 years. The revised guideline should aim to further improve reproductive and developmental (DART) safety testing for new drugs. Alternative methods to animal experiments should be used whenever possible. Modern technology should be used to obtain high quality data from fewer animals. Additions to the guideline should include considerations on the following: limit dose setting, maternal toxicity, biopharmaceuticals, vaccines, testing strategies by indication, developmental immunotoxicity, and male-mediated developmental toxicity. Emerging issues, such as epigenetics and the microbiome, will most likely pose challenges to DART testing in the future. It is hoped that the new guideline will be adopted even outside the ICH regions.

  3. Pharmacovigilance-related topics at the level of the International Conference on Harmonisation (ICH).

    Science.gov (United States)

    Bahri, Priya; Tsintis, Panos

    2005-06-01

    Marketing authorisations for medicines need to be based on the universal criteria quality, safety and efficacy, whilst taking into account local public health needs. With view to using resources efficiently and avoiding delay in access to medicines, scientific standards for investigating quality, safety and efficacy should be universal too. A major step to achieve this was taken in 1990 when the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) was established between authorities and industry in the European Union (EU), Japan and the United States. Since then more than 50 ICH Guidelines have been published, out of which six are specific to pharmacovigilance. They refer to management and expedited reporting of individual adverse drug reaction (ADR) cases, including electronic formats, periodic reporting of worldwide data and planning of pharmacovigilance. Their development has to be seen in the context of initiatives taken in the three ICH Regions to strengthen pharmacovigilance. Most recently this involves making use of risk management concepts, reflecting new thinking of proactivity in pharmacovigilance. Moreover, consideration is given to regional and international cooperation beyond the ICH Regions.

  4. Manuscritos freudianos inéditos: das ich und das es

    Directory of Open Access Journals (Sweden)

    Juan Carlos Cosentino

    2013-04-01

    Full Text Available Apresentamos aqui uma leitura crítica e comparada entre o rascunho e a forma final de O ego e o id, no momento em que nasce uma dissimetria entre o inconsciente reprimido e o material inconsciente que permanece não reconhecido. Partimos do capítulo "Os dois tipos de pulsão". O próprio Freud nos lembra que as questões aí levantadas retomam pensamentos iniciados em 1920. A partir da redefinição do Inconsciente e, mais tarde, com a reformulação da ideia de pulsão de morte, tais considerações permanecem mais perto da psicanálise que do texto Além.... Não obstante, o que denomina "nossa especulação" retorna nas conclusões do capítulo IV sobre o pressuposto da pulsão de morte. Com a irrupção do não-ligado, quais são os propósitos da pulsão de morte, em 1923, quando esta tem as mãos livres? Em 1924, constata que não-toda a pulsão está inscrita na representação. Intervém o silêncio da pulsão: essa fronteira, onde o id fala, o id goza e nada sabe.Freudian unpublished manuscripts: das Ich und das Es. This is a critical and comparative reading of the manuscripts of The Ego and the Id. We can read in this work a dissymmetry between the repressed unconscious and the material that remains unknown. We depart from chapter IV, "The two kinds of Drives". As Freud announces, the matters he displays resume thoughts from his writings of 1920. So, starting with the redefinition of Ucs and afterwards, with the reformulation of the idea of Todestrieb, they remain much closer to psychoanalysis than Beyond the pleasure principle. But what he calls, "our speculation" returns in the conclusions of chapter IV about the assumption of the Todestrieb. With the breaking through of the not bound: what are the purposes the Todestrieb serves, when, as he says in 1923, it has its hands free? In 1924 he confirms that not-all the drive is inscribed in the representation. The silence of the drive intervenes: this border, where id speaks, id enjoys

  5. Prediction and prognostication of neurological deterioration in patients with acute ICH

    DEFF Research Database (Denmark)

    Ovesen, Christian; Christensen, Anders Fogh; Havsteen, Inger

    2015-01-01

    OBJECTIVE: Patients with intracerebral haemorrhage (ICH) are at high risk of neurological deterioration (ND). We aimed at establishing predictors of early ND (END) as well as late ND (LND) and at exploring the impact of neurological stability during the first week on long-term prognosis. DESIGN: We...... conducted this study as a retrospective cohort study. ND was evaluated based on the consciousness and severity of neurological symptoms. ND during the first 24 h after admission was defined as early ND and from 24 h to 7 days as LND. Patients were followed up until February 2015. PARTICIPANTS: We included...... 300 patients with acute ICH (≤4.5 h from symptom onset) who were admitted to our institution from March 2009 to January 2015. SETTING: Section of Acute Neurology, Department of Neurology, Bispebjerg Hospital is a specialised referral centre receiving patients with acute stroke from the entire capital...

  6. Prospects for developmental immunotoxicity guidance and an update on ICH S8.

    Science.gov (United States)

    Hastings, Kenneth L

    2005-10-01

    Potential adverse effects of drug exposure on the developing immune system had been a relatively neglected area of toxicology until fairly recently. However, with the recent regulatory emphasis on evaluation of drugs for use in pediatric patients, juvenile animal studies have been considered in much more detail than in the past in order to enable clinical trials. Assessment of immunotoxicity potential in these juvenile animal studies has been a natural consequence of drug development for pediatric patients. Unfortunately, the efforts to evaluate developmental immunotoxicity studies have not kept pace with the writing of an immunotoxicology guidance for the International Conference on Harmonisation of Technical Requirements for Registration of Human Pharmaceuticals (ICH). This document has recently reached Step 4 in the approval process: it is thus likely that juvenile animal studies for immunotoxicity would be recommended based on considerations enumerated in the ICH Safety Number 8 (S8) guidance. Sufficient flexibility exists in this document to cover the issue of developmental immunotoxicity. ICH S8 advocates a weight-of-evidence approach, which should be interpreted to indicate that immunotoxicity testing would be conducted based on identified cause(s) for concern rather than as a routine screening method. The presentation reflecting these issues, as presented to attendees of the Pharmaceutical Education Associates workshop on Innovative Methods and Applications for Risk Assessment in Pharmaceutical Development is summarized herein.

  7. La metropoli dell’agente ich=Spaik: Libidissi di Georg Klein

    Directory of Open Access Journals (Sweden)

    Moira Paleari

    2014-05-01

    Full Text Available My paper focuses on Georg Klein’s Libidissi (1998 as an example of a new spy-story in contemporary German literature. Combining the analysis of the role of the German spy ich=Spaik, the main figure of Klein’s novel, with a mapping of the geographies of the city Libidissi, I will point out to what extent the author poses a challenge to the tradition of the spy-story and in what way he considers Ich=Spaik’s activities, intending them not only as an operation of espionage, but especially as a persistent questioning of a problematic identity, of a figure, who is continuously confronting the image of his native country, his original belonging with the Other. The representation of ich=Spaik’s ‘displaced’ identity and his approach to the landscape, the (invisible town Libidissi, will be debated on two specific aspects: the paradigms of Self vs Other and of center vs periphery.

  8. 中国GMP与欧盟GMP-ICH Q7的比较%Comparison of Chinese GMP and EU ICH Q7

    Institute of Scientific and Technical Information of China (English)

    汪敏

    2008-01-01

    了解中国GMP与国际GMP之间的差异,为法规制定和药品生产企业提供参考.从立法、指南、检查几个方面对欧盟原料药GMP-ICH Q7进行了简要介绍,并与中国GMP展开深入的对比,主要包括GMP起点、人员、厂房和设施、物料管理、验证、文件、生产管理和质量管理.中国GMP在许多重要方面与国际先进水平存在明显差距.我们共同期待我国新版GMP规范的出台.

  9. Shielding optimisation of the ITER ICH&CD antenna for shutdown dose rate

    Energy Technology Data Exchange (ETDEWEB)

    Turner, Andrew, E-mail: andrew.turner@ccfe.ac.uk [CCFE, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Leichtle, Dieter [Fusion for Energy, Josep Pla 2, Torres Diagonal Litoral B3, 08019 Barcelona (Spain); Lamalle, Philippe; Levesy, Bruno [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St., Paul-lez-Durance (France); Meunier, Lionel [Fusion for Energy, Josep Pla 2, Torres Diagonal Litoral B3, 08019 Barcelona (Spain); Polunovskiy, Eduard [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St., Paul-lez-Durance (France); Sartori, Roberta [Fusion for Energy, Josep Pla 2, Torres Diagonal Litoral B3, 08019 Barcelona (Spain); Shannon, Mark [CCFE, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom)

    2015-10-15

    Highlights: • Neutronics analysis on the ITER ICH&CD system conducted to reduce shutdown dose rate. • Several designs for shielding the port plug gaps were modelled. • Shielding significantly reduced interspace dose rate but still exceed project requirements. • Design optimisation of the ICH port is continuing. • Significant contributions from other ports require an integrated modelling approach. - Abstract: The Ion Cyclotron Heating and Current Drive (ICH&CD) system will reside in ITER equatorial port plugs 13 and 15. Shutdown dose rates (SDDR) within the port interspace are required to be less than 100 μSv/h at 10{sup 6} s cooling. A significant contribution to the SDDR results from neutrons streaming down gaps around the port frame, and the mitigation of this streaming is the main subject of these analyses. An updated MCNP model of the antenna was created and integrated into an ITER reference model. Shielding plates were defined in the port gaps, and scoping studies conducted to assess their effectiveness in several configurations, based on which a front dog-leg arrangement was selected for high resolution 3-D activation analysis using MCR2S. It was concluded that the selected configuration reduced the SDDR from ∼500 μSv/h to 220 μSv/h but were still in excess of dose rate requirements. Approximately 30% of this was due to cross-talk from neighbouring ports. In addition, increased dose rates were observed in the port interspace along the lines of sight of the removable vacuum transmission lines. Design optimisation is continuing, however an integrated approach is needed with regard to ITER port plug design and the shielding of surrounding systems.

  10. CIOMS and ICH initiatives in pharmacovigilance and risk management: overview and implications.

    Science.gov (United States)

    Tsintis, Panos; La Mache, Edith

    2004-01-01

    In this article we review the current initiatives by the Council for International Organizations of Medical Sciences (CIOMS) and the International Conference on Harmonisation (ICH) on pharmacovigilance planning that are due for general release during 2004. These initiatives could form the basis for applying concepts of risk management to medicines throughout their life cycle, from preclinical and clinical development to marketed use. The CIOMS VI Working Group (with 28 senior scientists worldwide from drug regulatory authorities and pharmaceutical companies) is currently developing scientific guidance that relates to clinical trials for medicines during development. It recommends a developmental pharmacovigilance concept - a 'living' concept that would start early in drug development supporting the science and ethics of research leading up to licensing (marketing authorisation) and continuing to post-authorisation (postmarketing) pharmacovigilance. This approach is seen as complementary to current ICH initiatives called 'Pharmacovigilance Planning'. ICH will introduce two concepts in pharmacovigilance management of medicinal products: the 'Pharmacovigilance Specification' and the 'Pharmacovigilance Plan'. The 'Pharmacovigilance Specification' will summarise important knowns and unknowns about the medicine. It will include safety risks identified at the licensing stage, potential risks and any key missing information. These elements will be essential to the formulation of pharmacovigilance plans. Dialogue and common understanding between regulators and the pharmaceutical industry will be a key factor for developing pharmacovigilance plans during the life cycle of medicines. Appropriate interaction with health professionals and patients should also be planned for the future as regulatory systems become more transparent. Where no significant issues are apparent at the licensing (marketing authorisation) stage, routine pharmacovigilance practices will be followed

  11. Kein Mensch ist ein Ich-Land [No man is an island]. The metaphorof an island in reflections on friendship

    Directory of Open Access Journals (Sweden)

    Joanna Roszak

    2010-01-01

    Full Text Available In her essay, the author recalls literary contexts (including John Donne, Michel Houellebecq and Ernest Hemingway and philosophical and anthropological contexts (including Aristotle, Thomas Merton, Maurice Blanchot, Jean-Paul Sartre and Gilles Deleuze presenting the poetic “I’s” various ways of approaching friendship. The quotation from a German translation of John Donne’s poem used in the title of the article is in itself a meaningful phonetic wordplay: “Kein Mensch ist ein Ich-Land” (no man is an “I” land, no man is an island. The main part of the essay includes an interpretation of the television series Lost — Joanna Roszak investigates philosophical references in the series and indicates biblical contexts (“Am I my brother’s keeper?”. A very apt comment to many episodes in the series is, according to the author, the formula told by Z. Herbert’s Fortinbras: Ani nam witać się ani żegnać żyjemy na archipelagach/ A ta woda te słowa cóż mogą cóż mogą” [It is not for us to greet each other or bid farewell we live on archipelagos/ and that water these words what can they do what can they do prince]. It is a similar defencelessness in which the main characters of Lost try to struggle the reality, even if they live together, and die all alone. Collective memory has become a safeguard for the community in the world, which is to be destined for homelessness and forlornness. The other person though becomes a reference point — it is him or her that makes it possible to find the way home.

  12. The ICH S5(R2) guideline for the testing of medicinal agents.

    Science.gov (United States)

    Wise, L David

    2013-01-01

    Relying on previous regulatory guidelines from multiple countries, the ICH S5(R2) guideline outlines the preclinical safety studies needed for registration of new medicinal products in the member countries (European Union, Japan, and the United States). The primary purpose of the guideline is to provide a testing strategy to detect and reveal toxicity to the reproductive system including development of the embryo. There are basically three study designs outlined by the guidance, assessment of fertility in adults, pre- and postnatal development of exposed offspring, and morphological evaluation following exposure during major organogenesis. This chapter discusses the major points addressed in the guidance for each study type, and points to additional references that discuss the practical details for conducting such studies.

  13. Duration of Acute and Chronic Toxicity Testing in Animals (ICH S4A and S4B)

    DEFF Research Database (Denmark)

    Spindler, Per; Van Cauteren, Herman

    2013-01-01

    for the ICH S4B guideline regarding the duration of non-rodent repeated dose toxicity studies is explained and lessons learned are discussed. Since the guideline was issued in 1997 changes occurred in e.g. the language of the European legislation, and the requirements for non-clinical studies to support...

  14. The ICH S8 immunotoxicity guidance. Immune function assessment and toxicological pathology: autonomous or synergistic methods to predict immunotoxicity?

    Science.gov (United States)

    Spanhaak, Steven

    2006-07-01

    The new ICH S8 guideline on Immunotoxicology Studies for Human Pharmaceuticals indicates that additional, functional testing of pharmaceuticals is not mandatory to screen for unintended immunotoxicity. The usefulness of conventional parameters like clinical pathology, organ weights and histopathology as measured in Standard Toxicity Studies (STS) to screen for potential unintended immunotoxicity was investigated in an ICH survey. Data of this survey appear to support the notion that properly evaluated STS endpoints would be sufficient for the detection of the majority of unintended immunosuppression by investigational pharmaceutical compounds. Thus the ICH S8 guideline was based on a cause for concern approach using a weight of evidence review of various factors like: findings from STS, pharmacological properties of the drug, intended patient population, structural similarities to known immunomodulators, drug disposition and/or clinical information. Overall the S8 guideline allows for more flexible approaches, and requires a weight of evidence review for which there is no given set of rules. For a proper use this asks for a sensible, realistic and above all a responsible approach both from Industry and Regulators. Some examples regarding the use of clinical pathology parameters like immunoglobulin levels and lymphocyte phenotyping have been included to illustrate this. In conclusion, to detect and evaluate potential immunotoxic effects of human pharmaceuticals the ICH S8 guideline allows for a more flexible, scientifically sound approach. For a proper evaluation of potential immunotoxic effects integration of data from standard toxicological parameters like clinical pathology, histopathology and functional assays are important.

  15. Duration of Acute and Chronic Toxicity Testing in Animals (ICH S4A and S4B)

    DEFF Research Database (Denmark)

    Spindler, Per; Van Cauteren, Herman

    2013-01-01

    To support approval of pharmaceuticals for long term use in humans it is required that product safety is supported by acute and chronic toxicity studies in rodents and non-rodents. The duration of acute toxicity studies (S4A) and chronic rodent studies (S4B) were harmonised between the three ICH ...

  16. Not In-Service Railway Arched Bridges and Their Future/ Nieużytkowane Kolejowe Mosty Sklepione I Ich Przyszłość

    Science.gov (United States)

    Juszczyk, Artur; Dankowski, Marek; Wysokowski, Adam

    2015-06-01

    At the turn of the 19th and 20th century, on the areas of today northern and western Poland, the railway infrastructure was developing rapidly. In the late 80's of the previous century many of the railway lines, together with the whole infrastructure including bridges, were being closed down. The example of such practices can be the brick bridge located near Nojewo, Voivodeship wielkopolskie. This article presents the technical parameters of these bridges and their damages as well as ideas for the future development of the railway facilities. Na przełomie XIX i XX wieku na terenie dzisiejszej Polski zachodniej i północnej bardzo intensywnie rozwijana była infrastruktura kolejowa. W efekcie tych działań powstała sieć dróg żelaznych o dużym zagęszczeniu. Pod koniec lat 80-tych ubiegłego stulecia wiele z tych linii było stopniowo zamykanych. Na skutek tych przemian wiele linii oraz obiektów z nimi związanych, w tym obiekty mostowe, zostały pozostawione niekorzystnemu działaniu czasu. Przykładem takich wyłączonych z eksploatacji obiektów są mosty i wiadukty położone w okolicy miejscowości Nojewo. Wspomniane obiekty inżynierskie to ceglane konstrukcje sklepione znajdujące się w ciągu linii kolejowej nr 368 łączącej Szamotuły i Międzychód. W artykule zaprezentowano problem rewitalizacji nieużytkowanych mostów kolejowych na przykładzie obiektów w miejscowości Nojewo w województwie wielkopolskim. Opisano podstawowe parametry techniczne mostów oraz ich uszkodzenia. Przedstawiono propozycje zagospodarowania obiektów.

  17. 新井白蛾的易学研究--兼谈江户时代的易占%Arai Hakuga’s Study on I-Ching and I-Ching Divination in the Edo Period

    Institute of Scientific and Technical Information of China (English)

    廖娟

    2016-01-01

    In the Edo period (1600-1868) of Japan, the study of I-Ching was developed into a kind of independent knowledge with the prosperity of Neo-Confucianism in that era. Along with intriguing the Japanese intellectuals to developing their philosophical thinking, I-Ching was also introduced into the social life of ordinary people as a book of divination, helping forming the social patterns of Edo Japan. This essay tries to introduce Arai Hakuga’s study, who was mainly an interpreter of I-Ching at that time, and who left many valuable I-Ching study works while was never treated seriously before. He placed emphasis on both theoretical and practical sides of I-Ching study, and especially tried hard to spread the divinatory methods in Japan. The author tries to discuss four main characters of his study: the “ancient I-Ching”, the emphasis on “image”, his divinatory methods and his open mind towards divination, hoping to reveal the divinatory side of I-Ching interpretations in Japan.%日本在进入江户时代以后,讨论《易》的知识较以前更为丰富,逐渐成为一门独立的学问,在触发知识分子思维精神的同时,也以易占的形式,介入民众的具体生活,塑造着近世日本社会形态的另外一面。本文所力图介绍的新井白蛾,有丰富的易学作品传世,也是易学理论与实践两方面皆重的人物,他强调了易在占卜上的实用性。本文以新井白蛾的“古易”、白蛾对“象”的重视、白蛾的易占方法及开放的易占态度四点展开论述,以求窥得日本江户时代易学在占卜活动中的另一个发展侧面。

  18. Influenceri na sociálnych sieťach a ich využitie v marketingu

    OpenAIRE

    Petrovčíková, Lucia

    2017-01-01

    This diploma thesis called "Influencers in Social media and their Use in Marketing" deals with the new current trend in which, instead of well-known celebrities, star just ordinary people. Despite of this, they managed to conquer the masses through social networks thanks to their unique personality and authenticity. The first chapter focuses on online marketing and explains the basic concept of it, its tools and communication mix, along with data on the structure of the Czech Internet populat...

  19. Hematoma shape, hematoma size, Glasgow coma scale score and ICH score: which predicts the 30-day mortality better for intracerebral hematoma?

    Directory of Open Access Journals (Sweden)

    Chih-Wei Wang

    Full Text Available To investigate the performance of hematoma shape, hematoma size, Glasgow coma scale (GCS score, and intracerebral hematoma (ICH score in predicting the 30-day mortality for ICH patients. To examine the influence of the estimation error of hematoma size on the prediction of 30-day mortality.This retrospective study, approved by a local institutional review board with written informed consent waived, recruited 106 patients diagnosed as ICH by non-enhanced computed tomography study. The hemorrhagic shape, hematoma size measured by computer-assisted volumetric analysis (CAVA and estimated by ABC/2 formula, ICH score and GCS score was examined. The predicting performance of 30-day mortality of the aforementioned variables was evaluated. Statistical analysis was performed using Kolmogorov-Smirnov tests, paired t test, nonparametric test, linear regression analysis, and binary logistic regression. The receiver operating characteristics curves were plotted and areas under curve (AUC were calculated for 30-day mortality. A P value less than 0.05 was considered as statistically significant.The overall 30-day mortality rate was 15.1% of ICH patients. The hematoma shape, hematoma size, ICH score, and GCS score all significantly predict the 30-day mortality for ICH patients, with an AUC of 0.692 (P = 0.0018, 0.715 (P = 0.0008 (by ABC/2 to 0.738 (P = 0.0002 (by CAVA, 0.877 (P<0.0001 (by ABC/2 to 0.882 (P<0.0001 (by CAVA, and 0.912 (P<0.0001, respectively.Our study shows that hematoma shape, hematoma size, ICH scores and GCS score all significantly predict the 30-day mortality in an increasing order of AUC. The effect of overestimation of hematoma size by ABC/2 formula in predicting the 30-day mortality could be remedied by using ICH score.

  20. Influence of I-ching (Yijing, or The Book Of Changes) on Chinese medicine, philosophy and science.

    Science.gov (United States)

    Lu, Dominic P

    2013-01-01

    I-Ching or Yi-Jing ([see text] also known as The Book of Changes) is the earliest classic in China. It simply explained the formation of the universe and the relationship of man to the universe. Most, if not all, branches of various knowledge, including traditional Chinese medicine, can be traced back its origin to this Book in which Fu Shi ([see text] 2852 B.C.) theorized how the universe was formed, through his keen observation of environment and orbits of sun, moon and stars. He used symbols to represent his views. The essence of I-Ching is basically the expression and function of Yang symbolized as "--" (from ) and Yin symbolized "- -" (from -->physics of sub-atomic particles, there are some basic theories in common.

  1. Intracerebral hemorrhage (ICH) evaluation with a novel magnetic induction sensor: a preliminary study using the Chinese head model.

    Science.gov (United States)

    Zhang, Ziyi; Liu, Peiguo; Zhou, Dongming; Zhang, Liang; Lei, Hengdong

    2014-01-01

    Biomedical magnetic induction measurement is a promising method for the detection of intracerebral hemorrhage (ICH), especially in China. Aiming at overcoming the problem of low sensitivity, a magnetic induction sensor is chosen to replace the conventional sensors. It uses a two-arm Archimedean spiral coil as the exciter and a circular coil as the receiver. In order to carry out high-fidelity simulations, the Chinese head model with real anatomical structure is introduced into this novel sensor for the first time. Simulations have been carried out upon early stage ICH measurements. By calculating the state sensitivity and time sensitivity of the perturbation phase of two types of sensors using the electromagnetic software, we conclude that the primary signal received can be largely reduced using the novel sensor, which could effectively increase the time and state sensitivity simultaneously.

  2. [Pediatric drug development: ICH harmonized tripartite guideline E11 within the United States of America, the European Union, and Japan].

    Science.gov (United States)

    Pflieger, M; Bertram, D

    2014-10-01

    To address the lack of appropriate pediatric drugs available on the global market, in 2000 the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) issued the ICH E11 guideline regarding the Clinical Investigation of Medicinal Products in the Pediatric Population. This guideline considerably changes the environment of drug development for children. It has been written specifically to harmonize, promote, and facilitate high-quality and ethical clinical research for children within the ICH regions, i.e., the United States of America (USA), the European Union (EU), and Japan. This article details the various regulations applicable in each ICH region following the publication of the guideline. The framework of rewards, incentives, and obligations for pharmaceutical companies established for the development of pediatric drugs are compared. It appears that the USA and the EU have both developed specific regulations for pediatric drug development while Japan has not. However, in Japan, pharmaceutical companies (PCs) are encouraged to develop pediatric drugs voluntarily, and they may be granted additional months of market exclusivity or the postponement of the drug re-examination deadline. In both the USA and the EU, regulations aimed to increase the number of clinical studies conducted in children, in order to ensure that the necessary data are generated, determining the conditions in which a drug may be authorized to treat the pediatric population. PCs are encouraged to develop pediatric assessment, including pediatric clinical trials, which is described in a pediatric plan submitted to the relevant authorities. A system of rewards for PCs submitting an application for marketing authorization containing pediatric use information has been put in place to cover the additional investment for testing drugs in children. Subject to conditions, these rewards consist in a 6-month extension of the patent or

  3. Laktační poradenství v okrese Jindřichův Hradec

    OpenAIRE

    2011-01-01

    The title of thesis is Lactational Consultancy in the district of Jindřichův Hradec and this is also the main topic of the thesis ? the meaning of the term and the general principles of becoming a good consultant in the field of brestfeeding. Lactational consultancy is supported by the lactational league and that is why this organization is mentioned in the thesis; it is an independent and non profit-making organization but it is the most important one in the field of this consultancy. The th...

  4. {beta} -carotene effect the induction of the sister chromatid exchanges (ICH) by gamma radiation in mouse radiosensibilized osseous marrow cells In vivo; Efecto del {beta}- caroteno la induccion de intercambios en las cromatidas hermanas (ICH) por radiacion gamma en celulas radiosensibilizadas de la medula osea de raton In vivo

    Energy Technology Data Exchange (ETDEWEB)

    Morales R, P.; Cruz V, V.L. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico). Dept. de Biologia

    1997-07-01

    The effect of {beta}- carotene over the ICH radioinduction in radiosensibilized with BrdU osseous marrow cells of mouse was determined In vivo. The treatment with 50 {mu}g {beta} carotene per se induces a significant increment in the ICH frequency and the pre or post-treatment with the same dose causes an additive effect in the ICH frequency produced by 0.62 Gy of gamma radiation. This implies that {beta}- carotene does not have radioprotective activity, under conditions which was developed this experiment. (Author)

  5. The clinical epidemiology of spontaneous ICH in a sub-Sahara African country in the CT scan era: a neurosurgical in-hospital cross-sectional survey

    Directory of Open Access Journals (Sweden)

    Amos Olufemi Adeleye

    2015-08-01

    Full Text Available Background There is paucity of data-driven scientific reports from sub-Saharan Africa on the burden of spontaneous intracerebral haemorrhage (sICH. We have maintained a prospective consecutive in-hospital data base of cases of sICH referred for neurosurgical intervention over a 5-year period. Methods This is a cross-sectional descriptive study of the clinical epidemiology and brain-CT characterization of sICH from the data base in this region in the current era. Results There were 63 subjects, 38 (60.3% males, aged 28 to 85 years, mean 55.7 (SD, 12.7, the modal age distribution being the sixth decade. Uncontrolled hypertension was the main predisposition in the study: present, premorbid, in 79% but uncontrolled in 88% of these known cases, and exhibited malignant derangements of blood pressure in more than half. The clinical ictus to in-hospital presentation was delayed, median 72 hours; was in severe clinical state in 70%; 57% was comatose, and was complicated with fever in 57% and respiratory morbidity also in 55.6%. The main clinical symptomatology was hemiparesis, headache, vomiting and aphasia. The sICH was supratentorial on brain CT in 85.7%, ganglionic in 50.8% and thalamic in 58.3% of the latter. The bleed had CT evidence of mass effect and intraventricular extension in more than half. Twenty three patients (36.5% underwent operative interventionsConclusions In this patient population, sICH is mainly ganglionic and thalamic in location with significant rate of associated IVH. In-hospital clinical presentation is delayed and in critical state, and, the bleeding is uncontrolled hypertension related in >95%.

  6. The Rise of Standard I (< Me Ich: A Contribution to the Study of Functional Change in English

    Directory of Open Access Journals (Sweden)

    Wełna Jerzy

    2014-12-01

    Full Text Available In its post-Norman Conquest development the Old English first person personal pronoun ic underwent transformations which, following the loss of the consonant, finally yielded the contemporary capitalised form I, contrasting with other Germanic languages, which retain a velar sound in the corresponding pronoun. The rather complex change of ich to I involves a loss of the final velar/palatal consonant, lengthening of the original short vowel, and capitalisation of the pronoun. It is argued here that the use of the capital letter was a consequence of vowel lengthening subsequent to the loss of the consonant. This seems to be confirmed by the observation that forms retaining a consonant are extremely rarely capitalised. The data adduced in the present paper will help verify as precisely as possible the distribution of the forms of that pronoun in Middle English dialects in order to determine to what extent the changes were functionally interdependent. The evidence comes from the Innsbruck Corpus of Middle English Prose.

  7. Dynamics of electron solvation in I(-)(CH3OH)n clusters (4 ≤ n ≤ 11).

    Science.gov (United States)

    Young, Ryan M; Yandell, Margaret A; Neumark, Daniel M

    2011-03-28

    The dynamics of electron solvation following excitation of the charge-transfer-to-solvent precursor state in iodide-doped methanol clusters, I(-)(CH(3)OH)(n = 4-11), are studied with time-resolved photoelectron imaging. This excitation produces a I···(CH(3)OH)(n)(-) cluster that is unstable with respect to electron autodetachment and whose autodetachment lifetime increases monotonically from ~800 fs to 85 ps as n increases from 4 to 11. The vertical detachment energy (VDE) and width of the excited state feature in the photoelectron spectrum show complex time dependence during the lifetime of this state. The VDE decreases over the first 100-400 fs, then rises exponentially to a maximum with a ~1 ps time constant, and finally decreases by as much as 180 meV with timescales of 3-20 ps. The early dynamics are associated with electron transfer from the iodide to the methanol cluster, while the longer-time changes in VDE are attributed to solvent reordering, possibly in conjunction with ejection of neutral iodine from the cluster. Changes in the observed width of the spectrum largely follow those of the VDEs; the dynamics of both are attributed to the major rearrangement of the solvent cluster during relaxation. The relaxation dynamics are interpreted as a reorientation of at least one methanol molecule and the disruption and formation of the solvent network in order to accommodate the excess charge.

  8. Dynamics of electron solvation in I-(CH3OH)n clusters (4 ≤ n ≤ 11)

    Science.gov (United States)

    Young, Ryan M.; Yandell, Margaret A.; Neumark, Daniel M.

    2011-03-01

    The dynamics of electron solvation following excitation of the charge-transfer-to-solvent precursor state in iodide-doped methanol clusters, I-(CH3OH)n=4-11, are studied with time-resolved photoelectron imaging. This excitation produces a I…(CH3OH)n- cluster that is unstable with respect to electron autodetachment and whose autodetachment lifetime increases monotonically from ˜800 fs to 85 ps as n increases from 4 to 11. The vertical detachment energy (VDE) and width of the excited state feature in the photoelectron spectrum show complex time dependence during the lifetime of this state. The VDE decreases over the first 100-400 fs, then rises exponentially to a maximum with a ˜1 ps time constant, and finally decreases by as much as 180 meV with timescales of 3-20 ps. The early dynamics are associated with electron transfer from the iodide to the methanol cluster, while the longer-time changes in VDE are attributed to solvent reordering, possibly in conjunction with ejection of neutral iodine from the cluster. Changes in the observed width of the spectrum largely follow those of the VDEs; the dynamics of both are attributed to the major rearrangement of the solvent cluster during relaxation. The relaxation dynamics are interpreted as a reorientation of at least one methanol molecule and the disruption and formation of the solvent network in order to accommodate the excess charge.

  9. Competitive dynamic I-Ching decision system%动态竞争易经决策系统

    Institute of Scientific and Technical Information of China (English)

    裴文; 林贵湖; 谭百玲

    2013-01-01

    建构动态竞争易经决策系统competitive dynamic I-Ching decision system,CDIDS,结合东西方系统思维为基础.本研究主探讨动态竞争的竞争者图像,以市场共同性及资源相似性为基础,整合竞争重要相似性易经决策的衡量方法,来计算竞争者间的竞争重要性认定相似度值.依据CDIDS衡量模式,以台湾进口汽车公司做实证分析,研究结果可以测量出不同竞争者的相对应象限位置,并可以辨识竞争者的竞争策略重要相关性;并且依据本研究CDIDS的系统,给予焦点厂商策略建议.

  10. High heat flux testing of ITER ICH&CD antenna beryllium faraday screen bars mock-ups

    Energy Technology Data Exchange (ETDEWEB)

    Courtois, X., E-mail: xavier.courtois@cea.fr [CEA, IRFM, F-13108 Saint-Paul-Lez-Durance (France); Meunier, L. [Fusion for Energy, 08019 Barcelona (Spain); Kuznetsov, V. [Efremov Institute, FSUE NIIEFA, St. Petersburg, 196641 (Russian Federation); Beaumont, B.; Lamalle, P. [ITER Organization, Route de Vinon sur Verdon, CS 90 046, 13067 St Paul Lez Durance (France); Conchon, D. [ATMOSTAT Co, F-94815 Villejuif (France); Languille, P. [CEA, IRFM, F-13108 Saint-Paul-Lez-Durance (France)

    2016-11-01

    Highlights: • ITER ICH&CD antenna beryllium faraday screen bars mock-ups were manufactured. • The mock-ups are submitted to high heat loads to test their heat exhaust capabilities. • The mock-ups withstand without damage the design limit load. • Lifetime is gradually reduced when the heat load is augmented beyond the design limit. • Thermal and mechanical behavior are reproducible, and coherent with the calculation. - Abstract: The Faraday Screen (FS) is the plasma facing component of ITER ion cyclotron heating antennas shielding. The requirement for the high heat exhaust, and the limitation of the temperatures to minimize strain and thus offer sufficient resistance to fatigue, imply the need for high conductivity materials and a high cooling flow rate. The FS bars are constructed by a hipping process involving beryllium tiles, a pure copper layer, a copper chrome zirconium alloy for the cooling channel and a stainless steel backing strip. Two FS bars small scale mock-ups were manufactured and tested under high heat flux. They endured 15,000 heating cycles without degradation under nominal heat flux, and revealed growing flaws when the heat flux was progressively augmented beyond. In this case, the ultrasonic test confirms a strong delamination of the Be tiles.

  11. I-.(CH3I)2 photoexcitation: The influence of dipole bound states on detachment and fragmentation

    Science.gov (United States)

    Van Duzor, Matthew; Mbaiwa, Foster; Lasinski, Joshua; Holtgrewe, Nicholas; Mabbs, Richard

    2011-06-01

    We present the results of a photoelectron imaging study of the I-.(CH3I)2 cluster anion over excitation wavelengths 355-260 nm. The resulting spectra and photoelectron angular distributions (PADs) suggest extensive electron-molecule interaction following photoexcitation. Fragmentation channels are observed subsequent to excitation between 355 and 330 nm. The origin of these features, which begin 200 meV and peak 70 meV below the X band direct detachment threshold, is described in terms of a predissociative dipole bound state. The nature of the fragments detected and the energetics of the channel opening argue strongly in favor of an asymmetric, head to tail cluster anion geometry posited by Dessent et al. [Acc. Chem. Res. 31, 527 (1998)], 10.1021/ar950061f. Above the direct detachment threshold, PADs display evidence of phenomena akin to electron-molecule scattering. The fragment anions disappear above the X band threshold but reappear some distance below the second (A) direct detachment band. At these energies there is also rapid variation of the X band PAD, an observation attributed to autodetachment via spin-orbit relaxation of the iodine core of the cluster.

  12. Marketingová situační analýza BK Lions Jindřichův Hradec

    OpenAIRE

    Hron, Patrik

    2014-01-01

    The aim of this bachelor thesis is to carry out an analysis of each part of marketing mix and the environment in which the BK Lions Jindřichův Hradec basketball club is situated. Suitable and applicable recommendations are suggested to make the marketing mix more effective based on analysis of marketing situation. The first part is focused on describing the marketing mix and marketing situational analysis at a theoretical level. The practical part describes particular marketing tools which ar...

  13. Im Dienste des Ich

    OpenAIRE

    Krüger, Steffen; Röske, Thomas

    2013-01-01

    Der Band mit Aufsätzen von deutschen, französischen und amerikanischen Wissenschaftlern würdigt den facettenreichen Forscher Ernst Kris (Wien 1900–1957 New York) aus den Blickwinkeln verschiedener Disziplinen. Tatsächlich muss man, um sein Schaffen zu umreißen, drei Berufsbezeichnungen bemühen: Kunsthistoriker, Psychoanalytiker und Kommunikationsforscher. Mit 22 Jahren hatte Kris sein Kunstgeschichtsstudium an der Wiener Universität mit einer Promotionsschrift zum Naturabgussverfahren in...

  14. Peniaze ako zdroj šťastia v našich životoch? (Is Money a Source of Happiness in our lives?

    Directory of Open Access Journals (Sweden)

    Otakar Horák

    2013-06-01

    Full Text Available This paper begins by referring to the research which distinguishes two different aspects of subjective well-being, namely 1. experiences of happiness – measured by frequency and intensity of joy, stress, anger, worry and sadness we experience at a certain moment and 2. life satisfaction. Survey shows that beyond an annual household income of $75 000 there is no increase in the experiences of happiness. The paper then refers to the psychological mechanisms and factors – namely hedonic adaptation, social comparison and stress as a result of a raise – that lower the capacity of money to buy us the experiences of happiness. Not only we get quickly used to the things we buy, money also puts us into stressful situations and makes us build barriers between people. The paper then specifies strategies of economic decision-making that contribute to the maximization of happiness, such as purchase of the experiences instead of the things, interrupted and postponed consumption, or prosocial spending. The research indicates that prosocial spending has higher causal impact on promoting happiness than personal spending. As a matter of fact, this phenomenon is not culturally limited to the West. Concluding assertion – expressed only in the form of hypothesis – says that prosocial spending which is a form of prosocial behavior strengthens – through production of happiness – mutual relations in the society (cooperation.

  15. Zmiany w funkcjonowaniu serwisu społecznościowego Facebook i ich wpływ na jego użyteczność marketingową

    OpenAIRE

    Roge, Michał

    2013-01-01

    The purpose of this study was to investigate the last changes in social media marketing. In particular, the aim was to examine and describe how and why changes, especially in Facebook EdgeRank algorithm, influences marketing activities. Author analyzed changes in Facebook platform which was held in 2012. The information which was gathered could have practical significance. The existing knowledge needs to be brought into the industrial purchasing perspective in the social media ...

  16. A comparative study of ICH validated novel spectrophotometric techniques for resolving completely overlapping spectra of quaternary mixtures

    Science.gov (United States)

    Ali, Nouruddin W.; Abdelwahab, Nada S.; Abdelkawy, M.; Emam, Aml A.

    2016-02-01

    A pharmaceutically marketed mixture of Yohimbine, Alpha-tocopheryl acetate, Niacin, and Caffeine co-formulated as a promising therapy for erectile dysfunction. Simultaneous determination of the aforementioned pharmaceutical formulation without prior separation steps was applied using mean centering of ratio spectra and triple divisor spectrophotometric methods. Mean centering of ratio spectra method depended on using the mean centered ratio spectra in three successive steps which eliminated the derivative steps and so the signal to noise ratio was improved. The absorption spectra of the prepared solutions were measured in the wavelength range of 215-300 nm in the concentration ranges of 1-15, 3-15, 1-20, and 3-15 μg mL- 1 for Yohimbine, Alpha-tocopheryl acetate, Niacin, and Caffeine, respectively. The amplitudes of the mean centered third ratio spectra were measured at 250 nm and 268 nm for Yohimbine and Alpha-tocopheryl acetate, respectively and at peak to peak 272-273 and 262-263 nm for Niacin and Caffeine, respectively. In triple divisor method each drug in the quaternary mixture was determined by dividing the spectrum of the quaternary mixture by a standard spectrum of a mixture containing equal concentrations of the other three drugs. First derivative of these ratio spectra was obtained where determination could be achieved without any interference from the other three drugs. Amplitudes of 1-15, 3-15, 1-15, and 3-15 μg mL- 1 were used for selective determination of Yohimbine, Alpha-tocopheryl acetate, Niacin, and Caffeine, respectively. Laboratory prepared mixtures were analyzed by the developed novel methods to investigate their selectivity also, Super Act® capsules were successfully analyzed to ensure absence of interference from additives. The developed methods were validated according to the ICH guidelines. The proposed methods were statistically compared with each other and with the reported methods; using student t-test, F-test, and one way ANOVA

  17. Evaluación citotóxica y de exposición a drogas psicoactivas, mediante las pruebas de índice proliferativo (IP y de intercambios entre cromátides hermanas (ICH's, en individuos del suroccidente colombiano

    Directory of Open Access Journals (Sweden)

    Carvajal S

    2001-06-01

    Full Text Available De 65.888 jóvenes del Cauca, 4.349 (6,6% consumen marihuana, 2.043 (3,1% consumen cocaína, 725 (1,1% consumen bazuco y 791 (1,2% consumen éxtasis. Fue necesario, por lo tanto, realizar un monitoreo genético de la población, mediante el logro de los siguientes objetivos:
    1. Identificar el efecto Citotóxico de las drogas psicoactivas determinando el IP en linfocitos de adictos y no adictos.
    2. Evaluar la exposición del material genético de los adictos y no adictos, cuantificando los ICHs en linfocitos.

  18. A multi-site comparison of in vivo safety pharmacology studies conducted to support ICH S7A & B regulatory submissions.

    Science.gov (United States)

    Ewart, Lorna; Milne, Aileen; Adkins, Debbie; Benjamin, Amanda; Bialecki, Russell; Chen, Yafei; Ericsson, Ann-Christin; Gardner, Stacey; Grant, Claire; Lengel, David; Lindgren, Silvana; Lowing, Sarah; Marks, Louise; Moors, Jackie; Oldman, Karen; Pietras, Mark; Prior, Helen; Punton, James; Redfern, Will S; Salmond, Ross; Skinner, Matt; Some, Margareta; Stanton, Andrea; Swedberg, Michael; Finch, John; Valentin, Jean-Pierre

    2013-01-01

    Parts A and B of the ICH S7 guidelines on safety pharmacology describe the in vivo studies that must be conducted prior to first time in man administration of any new pharmaceutical. ICH S7A requires a consideration of the sensitivity and reproducibility of the test systems used. This could encompass maintaining a dataset of historical pre-dose values, power analyses, as well as a demonstration of acceptable model sensitivity and robust pharmacological validation. During the process of outsourcing safety pharmacology studies to Charles River Laboratories, AstraZeneca set out to ensure that models were performed identically in each facility and saw this as an opportunity to review the inter-laboratory variability of these essential models. The five in vivo studies outsourced were the conscious dog telemetry model for cardiovascular assessment, the rat whole body plethysmography model for respiratory assessment, the rat modified Irwin screen for central nervous system assessment, the rat charcoal meal study for gastrointestinal assessment and the rat metabolic cage study for assessment of renal function. Each study was validated with known reference compounds and data were compared across facilities. Statistical power was also calculated for each model. The results obtained indicated that each of the studies could be performed with comparable statistical power and could achieve a similar outcome, independent of facility. The consistency of results obtained from these models across multiple facilities was high thus providing confidence that the models can be run in different facilities and maintain compliance with ICH S7A and B. Copyright © 2013 Elsevier Inc. All rights reserved.

  19. Patient Experience Assessment is a Requisite for Quality Evaluation: A Discussion of the In-Center Hemodialysis Consumer Assessment of Health Care Providers and Systems (ICH CAHPS) Survey.

    Science.gov (United States)

    Cavanaugh, Kerri L

    2016-01-01

    Patient experience surveys provide a critical and unique perspective on the quality of patient-centered healthcare delivery. These surveys provide a mechanism to systematically express patients' voice on topics valued by patients to make decisions about choices in care. They also provide an assessment to healthcare organizations about their service that cannot be obtained from any other source. Regulatory agencies have mandated the assessment of patients' experience as part of healthcare value based purchasing programs and weighted the results to account for up to 30% of the total scoring. This is a testimony to the accepted importance of this metric as a fundamental assessment of quality. After more than a decade of rigorous research, there is a significant body of growing evidence supporting specifically the validity and use of the Consumer Assessment of Healthcare Providers and Systems (CAHPS) surveys, including a version specific to in-center hemodialysis (ICH CAHPS). This review will focus on the ICH CAHPS survey including a review of its development, content, administration, and also a discussion of common criticisms. Although it is suggested that the survey assesses activities and experiences that are not modifiable by the healthcare organization (or the dialysis facility in our case) emerging evidence suggests otherwise. Dialysis providers have an exclusive opportunity to lead the advancement of understanding the implications and serviceability of the evaluation of the patient experience in health care. © 2016 Wiley Periodicals, Inc.

  20. Regulatory incentives to ensure better medicines for older people: From ICH E7 to the EMA reflection paper on quality aspects.

    Science.gov (United States)

    van Riet-Nales, Diana A; Hussain, Nasir; Sundberg, Katarina A E; Eggenschwyler, Doris; Ferris, Cristina; Robert, Jean-Louis; Cerreta, Francesca

    2016-10-30

    Ageing comes with an increased propensity in the alteration of human organ and body functions, which can e.g. result in multi-morbidity, frailty, polypharmacy, altered medication safety and/or efficacy, and problems with the practical use of medicines in a real world setting. Such problems may e.g. involve difficulties opening containers, swallowing large tablets, breaking tablets by hand, or correctly understanding the user instruction. This review aims to summarize the European regulatory activities towards better medicines for older people, with a main focus on formulation development and the overall drug product design. It addresses the ICH E7 guideline "Studies in support of special populations, geriatrics", the ICH Q8 guideline "Pharmaceutical development", the EMA good practice guide on "Risk minimisation and prevention of medication errors" and the forthcoming EMA CHMP QWP reflection paper on the "Quality aspects (pharmaceutical development) of medicines for older people". In addition, three key aspects to the practical use of medicines by older people are discussed in a wider context: multi-particulates including small tablets (also referred to as mini-tablets), ease of opening and storage conditions. Furthermore, attention is paid to work in progress e.g. incentives by the European national drug regulatory authorities, and patient centric drug product development.

  1. International Conference on Harmonisation; Guidance on Q4B Evaluation and Recommendation of Pharmacopoeial Texts for Use in the ICH Regions; Annex on Residue on Ignition/Sulphated Ash General Chapter; Availability. Notice.

    Science.gov (United States)

    2008-02-21

    The Food and Drug Administration (FDA) is announcing the availability of a guidance entitled "Q4B Evaluation and Recommendation of Pharmacopoeial Texts for Use in the ICH Regions; Annex 1: Residue on Ignition/Sulphated Ash General Chapter.'' The guidance was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). The guidance provides the results of the ICH Q4B evaluation of the Residue on Ignition/Sulphated Ash General Chapter harmonized text from each of the three pharmacopeias (United States, European, and Japanese) represented by the Pharmacopoeial Discussion Group (PDG). The guidance conveys recognition of the three pharmacopeial methods by the three ICH regulatory regions and provides specific information regarding the recognition. The guidance is intended to recognize the interchangeability among these texts from the local regional pharmacopeias, thus avoiding redundant testing in favor of a common testing strategy in each regulatory region. Elsewhere in this issue of the Federal Register, FDA is announcing the availability of a guidance on the Q4B process entitled "Q4B Evaluation and Recommendation of Pharmacopoeial Texts for Use in the ICH Regions."

  2. Zadania działów zasobów ludzkich i ich ocena – model empiryczny

    NARCIS (Netherlands)

    Brandl, J.; Fink, M.; Kraus, G.S.

    2008-01-01

    W niniejszym artykule autorzy przed­staw­iają oparty na empirii model depar­ta­mentu zarządza­nia zasobami ludzkimi (ZZL), który wyjaś­nia dzi­ała­nia i kry­te­ria oceny dzi­ałów ZL z per­spek­tywy menedżerów. Model stwor­zony został w opar­ciu o eksplo­racyjne bada­nia aus­tri­ac­kich menedżerów. D

  3. ‘Wo soll ich hinfliehen vor diesem Mensch?’: Een luisteroefening in Ludwig Hofacker (1797−1828

    Directory of Open Access Journals (Sweden)

    Johan Kommers

    2013-11-01

    Full Text Available De aanwezigheid van de levende God in preken kunnen wij niet terzijde stellen of verontachtzamen. Waar dit wel gebeurt, daar wordt verkondiging een voordracht, zonder de volmacht. Orthodoxie komt in ademnood wanneer exegese en dogmatiek opgaan in een aantal meningen en waarbij het getuigenis van de Bijbel op de achtergrond komt. Ludwig Hofacker (1798–18281 was een prediker die in bijbelonderzoek en prediking zijn oor te luisteren legde aan de Bron. Het Woord van God was voor hem hét homiletisch magazijn. Dat nu nog steeds, in de 21e eeuw, zijn preken gelezen worden, geeft aan dat zijn erfenis een opmerkelijke is. Hij pakte het probleem van de geestelijke dorheid op in een tijd gekenmerkt door het opkomend klimaat van het humanistisch rationalisme. Hofackers prediking geeft weer waar het werkelijk om gaat: Christus alleen. Deze preken laten ook de prediker zelf zien. Zijn stem roept op wat de Reformatie zo na aan het hart lag, en de cadenzen van het sola gratia, sola Scriptura, en het sola fide zijn in elke preek te horen. Het religieuze eigene van Hofacker sluit grote missionaire bewogenheid in.In sermons we cannot disregard the presence of the living God, otherwise preaching will become a performance, without divine authority. Orthodoxy will be gasping for breath when exegesis and dogmatic theology are wholly absorbed in a number of opinions, causing biblical testimony to recede into the background. Ludwig Hofacker (1798–1828, was a preacher who in Bible study and preaching put his ears to the Fountain. The Word of God was his sole homiletic storehouse. Today, in our 21st century, his sermons are still being read. This indicates that he left us a remarkable body of work. He tackled the problem of spiritual dearth in a time of emerging humanistic rationalism. Hofacker’s preaching reflected his core belief: Christ only. His sermons also reflect the preacher himself. His voice clearly recalls what was held so dear in the Reformation, and

  4. Study and ICH validation of a reverse-phase liquid chromatographic method for the quantification of the intact monoclonal antibody cetuximab

    Directory of Open Access Journals (Sweden)

    Antonio Martínez-Ortega

    2016-04-01

    Full Text Available Cetuximab (CTX is a potent chimeric mouse/human monoclonal antibody (mAb approved worldwide for treatment of metastatic colorectal cancer. Among the various biological and physical analyses performed for full study on this biopharmaceutic, the determination of the concentration preparations throughout manufacturing and subsequent handling in hospital is particularly relevant. In the present work, the study and validation of a method for quantifying intact CTX by reverse-phase high-performance liquid chromatography with diode array detection ((RPHPLC/DAD is presented. With that end, we checked the performance of a chromatographic method for quantifying CTX and conducted a study to validate the method as stability-indicating in accordance with the International Conference on Harmonization guidelines (ICH for biotechnological drugs; therefore, we evaluated linearity, accuracy, precision, detection and quantification limits, robustness and system suitability. The specificity of the method and the robustness of the mAb formulation against external stress factors were estimated by comprehensive chromatographic analysis by subjecting CTX to several informative stress conditions. As demonstrated, the method is rapid, accurate, and reproducible for CTX quantification. It was also successfully used to quantify CTX in a long-term stability study performed under hospital conditions.

  5. ICH GUIDANCE IN PRACTICE: DEVELOPMENT OF A VALIDATED STABILITY-INDICATING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ASSAY METHOD FOR FEBUXOSTAT AND DEGRADATION KINETIC STUDY IN ACID HYDROLYTIC CONDITION

    Directory of Open Access Journals (Sweden)

    Megha V. Sheth* and Jigar J. Pandya

    2013-02-01

    Full Text Available The degradation behavior of Febuxostat was investigated under different stress degradation (hydrolytic, oxidative, photolytic and thermal conditions recommended by International Conference on Harmonization (ICH using HPLC and LCMS. Febuxostat was found to degrade significantly in acidic and alkaline conditions as well as in neutral hydrolysis. The drug was stable to dry heat, photolytic degradation and under oxidative condition. Resolution of drug and the degradation products formed under different stress studies were successfully achieved on a C-18 column utilizing Methanol- water (with 0.02%v/v TFA in the ratio of 95:5 and at the detection wavelength of 315 nm. The method was validated with respect to linearity, precision, accuracy, selectivity and specificity. The degradation kinetic of Febuxostat in acidic condition at different temperature was studied. The reaction order for Febuxostat in aqueous solvent system followed pseudo first order degradation kinetic. The catalytic rate constant and half-life at particular condition were determined. The Arrhenius plot showed the temperature dependence of Febuxostat.

  6. Study and ICH validation of a reverse-phase liquid chromatographic method for the quantification of the intact monoclonal antibody cetuximab$

    Institute of Scientific and Technical Information of China (English)

    Antonio Martínez-Ortega; Agustín Herrera; Antonio Salmerón-García; José Cabeza; Luis Cuadros-Rodríguez; Natalia Navas

    2016-01-01

    Cetuximab (CTX) is a potent chimeric mouse/human monoclonal antibody (mAb) approved worldwide for treatment of metastatic colorectal cancer. Among the various biological and physical analyses per-formed for full study on this biopharmaceutic, the determination of the concentration preparations throughout manufacturing and subsequent handling in hospital is particularly relevant. In the present work, the study and validation of a method for quantifying intact CTX by reverse-phase high-perfor-mance liquid chromatography with diode array detection ((RP)HPLC/DAD) is presented. With that end, we checked the performance of a chromatographic method for quantifying CTX and conducted a study to validate the method as stability-indicating in accordance with the International Conference on Harmo-nization guidelines (ICH) for biotechnological drugs; therefore, we evaluated linearity, accuracy, preci-sion, detection and quantification limits, robustness and system suitability. The specificity of the method and the robustness of the mAb formulation against external stress factors were estimated by compre-hensive chromatographic analysis by subjecting CTX to several informative stress conditions. As de-monstrated, the method is rapid, accurate, and reproducible for CTX quantification. It was also suc-cessfully used to quantify CTX in a long-term stability study performed under hospital conditions.

  7. Long term stability of rh-Cu/Zn-superoxide dismutase (SOD)-liposomes prepared by the cross-flow injection technique following International Conference on Harmonisation (ICH)-guidelines.

    Science.gov (United States)

    Vorauer-Uhl, Karola; Wagner, Andreas; Katinger, Hermann

    2002-07-01

    The current market position of liposomes as drug carriers is still being discussed with regard to large scale production, product characterisation and the stability of the dispersions. In this study, long term stability of liposomal suspensions with encapsulated rh-Cu/Zn-superoxide dismutase was tested according to the International Conference on Harmonisation (ICH) recommendations. The guidelines of the ICH provide general requirements for stability testing for registration and export in particular. The Institute of Applied Microbiology has examined a process to produce large amounts of pharmaceutical-grade liposomes for the treatment of inflammatory diseases by topical application. For the evaluation of its long-term storage stability, liposomal stability and protein stability were tested under appropriate conditions. Therefore, size alterations of the vesicles, protein release and protein activity were evaluated. During the observation period, neither significant alterations of the liposomes nor any protein degradation could be detected. In the light of these findings our liposomal formulations seem to provide chemical, physical and biological stability according to the definitions of the ICH. Appropriate lipid compounds and environmental factors, in combination with an optimised process and adequate storage conditions, facilitate the production of liposome dispersions suitable as drug carriers on the market.

  8. Development and validation of stability indicating method for determination of sertraline following ICH guidlines and its determination in pharmaceuticals and biological fluids

    Directory of Open Access Journals (Sweden)

    El-Enany Nahed M

    2011-10-01

    Full Text Available Abstract Background Sertraline is a well known antidepressant drug which belongs to a class called selective serotonin reuptake inhibitor. Most published methods do not enable studying the stability of this drug in different stress conditions. Results Two new methods were developed for the determination of sertraline (SER. Both methods are based on coupling with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl in borate buffer of pH 7.8 and measuring the reaction product spectrophotometrically at 395 nm (Method I or spectrofluorimetrically at 530 nm upon excitation at 480 nm (Method II. The response-concentration plots were rectilinear over the range 2-24 μg/mL and 0.25-5 μg/mL for methods I and II respectively with LOD of 0.18 μg/mL and 0.07 μg/mL, and LOQ of 0.56 μg/mL and 0.21 μg/mL for methods I and II, respectively. Conclusion Both methods were applied to the analysis of commercial tablets and the results were in good agreement with those obtained using a reference method. The fluorimetric method was further applied to the in vivo determination of SER in human plasma. A proposal of the reaction pathway was presented. The spectrophotometric method was extended to stability study of SER. The drug was exposed to alkaline, acidic, oxidative and photolytic degradation according to ICH guidelines. Moreover, the method was utilized to investigate the kinetics of oxidative degradation of the drug. The apparent first order rate constant and t1/2 of the degradation reaction were determined.

  9. Motywy wędrówki dusz i dybuka w kulturze żydowskiej i ich współczesna realizacja w twórczości Jony Wolach

    Directory of Open Access Journals (Sweden)

    Anna Piątek

    2016-06-01

    Full Text Available Motifs of transmigration of souls and dybbuk in Jewish culture and their contemporary implementation in the works by Yona Wollach This article describes two concepts important for Jewish mysticism – dybbuk and the transmigration of soul, and goes on to present their contemporary usage in the works by Yona Wollach. The concept of the transmigration of souls (in Hebrew: gilgul neshamot describes a situation whereby the soul of a dead person returns to the this world and occupies a new body. In the case of the dybbuk (in Hebrew: dibuk, on the other hand, the body of a living person, who has his or her own soul, is possessed by the spirit of a dead person. The concepts of reincarnation and dybbuk played an important role not only in religious tradition but also in folklore and popular and high culture. Both became the focus of a number of artworks. The article presents fragments of the poems of the Israeli poet Yona Wollach (1944–1985, in which she describes psychological states similar to transmigration of souls and being captured by a dybbuk. The article aims to show that these poetic images are in close connection with Wollach`s concept of the human psyche.   Motywy wędrówki dusz i dybuka w kulturze żydowskiej i ich współczesna realizacja w twórczości Jony Wolach Artykuł przybliża dwa ważne pojęcia mistyki żydowskiej – dybuka i wędrówki dusz, a następnie ukazuje współczesne nawiązanie do nich w twórczości Jony Wolach. Pod pojęciem wędrówki dusz (hebr. gilgul neszamot rozumie się sytuację, w której dusza zmarłego wraca do świata doczesnego i zamieszkuje w nowym ciele. Natomiast w przypadku dybuka (hebr. dibuk dochodzi do zawładnięcia ciałem żywego człowieka, posiadającego już jedną duszę, przez ducha zmarłej wcześniej osoby. Pojęcia wędrówki dusz i dybuka odgrywały istotną rolę nie tylko w tradycji religijnej, ale i w folklorze oraz kulturze popularnej i wysokiej, stając się tematem wielu dzie

  10. The activity of radiocaesium in sediments around off Fukushima after the accident of TEPCO's Fukushima Dai-ich Nuclear Power Station.

    Science.gov (United States)

    Fukuda, Miho; Aono, Tatsuo; Yoshida, Satoshi; Naganuma, Sho; Kubo, Atsushi; Ito, Yukari; Ishimaru, Takashi; Kanda, Jota

    2014-05-01

    The 2011 off the Pacific coast of Tohoku Earthquake and tsunami on March 11, 2011 have led to the accident of TEPCO's Fukushima Dai-ich Nuclear Power Station (FNPS) and large amount of radioactive material were discharged by the hydrogen explosion and leaked from FNPS to the ocean. About three years have passed after the accident, radiocaesium in seawater off Fukushima except for part of area is gradually decreasing to the level before the accident. However, because the decrease of radiocaesium in marine sediment is more slowly than that in seawater, it is worried to influence on marine biota dwelled around the seabed over the long term. The aim of this study was to elucidate the variation and behavior of radiocaesium (134Cs and 137Cs) activities in the marine environment. Sediment and seawater samples were collected from three sites in 5 km-20 km area from FNPS (NP2 site ; 37° 25 N, 141°06 E, water depth 30 m, AN6 site ; 37° 33 N, 141°07 E, water depth 30 m, and M01 site ; 37° 33 N, 141°20 E, water depth 60 m) in May and October 2013 during some cruise of Umitaka-maru and Shinyo-maru (Tokyo University of Marine and Technology) .Vertical changes of 134Cs concentration (Bq/kg-dry) in sediment ranged 17-28, 8.2-53, and 4.2-11 at NP2, AN6 and M01 sites as of May 2013, respectively. At NP2 site, 134Cs inventory (Bq/m2) in seawater in October was about four times higher than that of 134Cs inventory in May. At NP2 and M01 sites in May, 134Cs concentration was higher in the shallow layer (0 cm-1 cm). On the contrary, at AN6 site in May and NP2 site in October, 134Cs concentration was higher in the middle layer (4 cm-5 cm). Trend of organic content at all stations were consistent with that of vertical change of 134Cs concentration. These results suggest that highest radiocaesium layer in the shallow as well as in the middle depth was caused by increase of river input and resedimentation.

  11. Występowanie, swoistość i krzyżowa reaktywność przeciwciał antybakteryjnych (Yersinia spp., Salmonella Enteritidis, Chlamydia trachomatis, Borrelia burgdorferi oraz ich znaczenie w diagnostyce niesklasyfikowanych zapaleń stawów

    Directory of Open Access Journals (Sweden)

    Jakub Ząbek

    2011-02-01

    Full Text Available Diagnostyka serologiczna niesklasyfikowanych zapaleń stawówo podejrzewanej etiologii infekcyjnej jest często uważana za podstawowąz uwagi na opóźnione objawy kliniczne w stosunku dowystąpienia infekcji. W prezentowanej pracy przedstawiono wynikibadań przeprowadzonych na 4830 surowicach pacjentów (w tymok. 53% dzieci i młodzieży, hospitalizowanych w 2009 r. w 4 od -działach klinicznych Instytutu Reumatologii w Warszawie.W badaniach zastosowano metodę immunoenzymatyczną (ELISA,a w przypadku konieczności potwierdzenia obecności przeciwciałdla Y. enterocolitica (u dzieci i B. burgdorferi – metodę immunoblotting(Western-blotting.Analizując uzyskane wyniki, stwierdzono podwyższony poziomprzeciwciał dla Yersinia spp. – w 35,3% surowic, dla S. Enteritidis –w 13%, Ch. trachomatis – w 10,6%, B. burgdorferi – w 14,7% (tab. I.Przeanalizowano występowanie przeciwciał poszczególnych klasw aspekcie ich przydatności diagnostycznej w określaniu infekcji.Szczególną uwagę zwracano na częste współwystępowanie w tejsamej surowicy przeciwciał dla kilku drobnoustrojów (w tychsamych klasach – w 56,8%, w różnych klasach – 20,7% (tab. III, IV.Potwierdzono obecność swoistych przeciwciał klasy IgA dla Yersiniaspp. w 60,8%, a klasy IgG – w 86,7%. Podobne badania nadswoistością przeciwciał dla B. burgdorferi wykazały ich potwierdzalnośćw 82,2% dla klasy IgG oraz w 45,9% dla klasy IgM (tab. II.Dodatkowo dokonano szczegółowej analizy częstości występowania przeciwciał dla swoistych antygenów Y. enterocolitica i B. burgdorferi(ryc. 1, 2.Diagnostyka serologiczna niesklasyfikowanych zapaleń stawówo podejrzewanej etiologii bakteryjnej: Yersinia spp., S. Enteritidis,Ch. trachomatis, B. burgdorferi, jest przydatna z racji opóźnionychobjawów klinicznych, jednakże obarczona wieloma trudnościamiinterpretacyjnymi, wynikającymi z:• częstego wykrywania przeciwciał w jednej klasie, zwłaszcza IgG,które nie

  12. SERWIS SPOŁECZNOŚCIOWY JAKO NARZĘDZIE DIALOGU Z WYBORCAMI. PROFILE POLSKICH PARTII POLITYCZNYCH NA FACEBOOKU

    Directory of Open Access Journals (Sweden)

    Kinga Karasek-Kędzior

    2015-02-01

    Full Text Available Przedmiotem tekstu jest sposób wykorzystywania Facebooka przez polskie partie polityczne i ich wyborców. W analizie – która objęła profile ośmiu partii, zarówno parlamentarnych, jak i pozaparlamentarnych – wzięto pod uwagę aktywność partii oraz użytkowników ich profili w umieszczaniu materiałów na profilach poszczególnych ugrupowań. Wyniki dowiodły, że zarówno politycy, jak i ich wyborcy traktują Facebooka przede wszystkim jako miejsce dystrybucji informacji. Treści o charakterze mobilizującym do aktywności czy mających na celu budowę tożsamości grupowej jest o wiele mniej. Jednocześnie trzeba podkreślić, że nie ma bezpośredniego związku między rolą odgrywaną przez partię na scenie politycznej a intensywnością korzystania przez nią z możliwości stwarzanych przez serwisy społecznościowe. Ugrupowania najlepiej wykorzystujące potencjał internetu to partie stosunkowo młode i walczące dopiero o silną pozycję polityczną.

  13. Siła nowoczesnych narzędzi internetowych i ich wkład w rozwój e-biznesu

    OpenAIRE

    2015-01-01

    W obecnych warunkach intensywnego rozwoju nowoczesnych technologii funkcjonowanie przedsiębiorstw zyskało nowe cechy i możliwości. Technologie obliczeniowe i elektronicznej wymiany informacji wielorako wpływają na sposoby działania firm. Z jednej strony stanowią narzędzia pomocne do usprawniania pracy przedsiębiorstw, z drugiej zaś mogą być podstawą do tworzenia nowych przedsięwzięć biznesowych. Wnioski zawarte w monografii ukazują konieczność pogłębiania wiedzy na temat zastosowania ...

  14. Implantação do Guia ICH Q8(R2): o processo de desenvolvimento farmacêutico sob uma abordagem científica e de gerenciamento de risco de qualidade

    OpenAIRE

    Fagundes, Renata Oliveira

    2012-01-01

    Esta dissertação avalia o impacto da aplicação do princípio de Quality by Design(QbD) apresentado no Guia ICH Q8(R2) Desenvolvimento Farmacêutico sobre a qualidade do processo de desenvolvimento e de produção de novos medicamentos de Farmanguinhos.O objetivo do desenvolvimento farmacêutico é projetar um produto de qualidade cujo processo de fabricação permita, de forma consistente, alcançar o desempenho pretendido com reprodutibilidade e confiabilidade. As informações e os conhecimentos adq...

  15. MĚSTSKÝ DŮM NA NÁBŘEŽÍ V PŘEROVĚ

    OpenAIRE

    Fedorková, Zuzana

    2010-01-01

    Na parcele sa nachádzajú 2 objemy budov, bytový a administratívny, ktoré sú vzájomne prepojené 1NP s parterom. Tento priestor sa otvára z južnej strany nábrežiu s kaviarenskou terasou a vťahuje okoloidúcich dovnútra. Z východnej strany sa priestor otvára na východ do ulice Malá dlážka a poskytuje pokoj v korunách stromov. Objekty a ich fasády vzájomne komunikujú, verejný priestor je jedným prepájajúcim kolobehom rôznych fáz nášho každodenného rytmu. On the land estate are situated 2 volume...

  16. Termiczne pory roku na Pomorzu Zachodnim w Stacji Geoekologicznej Zintegrowanego Monitoringu Środowiska Przyrodniczego w Storkowie w latach 1987-2007

    OpenAIRE

    Franków, Karolina

    2008-01-01

    W pracy analizowano występowania termicznych pór roku na Pomorzu Zachodnim w Stacji Geoekologicznej ZMOEP w Storkowie. Interpretacji i opisu wyników dokonano na podstawie pomiarów średnich dobowych temperatur powietrza w latach 1987–2007. Zastosowano podział roku na sześć termicznych pór według MERECKIEGO, ROMERA i in. (1949), uwzglêdniając następujące progi termiczne: 0,0°C, 5,0°C, 15°C. Szczególną uwagę zwrócono na skrajne daty ich występowania oraz czas trwania. Uzyskane ...

  17. Obecność w powietrzu atmosferycznym grzybów z gatunku Fusarium culmorum i ich oporność na antymikotyki – hipotetyczne zagrożenie dla zdrowia ludzi

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    Katarzyna Wolny-Koładka

    2016-03-01

    Full Text Available Introduction. In the atmospheric air, fungal spores of the genus Fusarium are present which may be resistant to antifungal drugs used in medicine. The aim of this study was to determine the sensitivity to selected antimycotics, and to identify the MIC (minimum inhibitory concentration for strains belonging to the species F. culmorum. Material and methods. Fungal strains were isolated from atmospheric air sampling in the vicinity of fields where winter wheat was cultivated. Evaluation of susceptibility to antifungal drugs was carried out using E-test strips. Results. All isolates were characterized by resistance to ketoconazole, itraconazole and fluconazole. MIC for amphotericin B was 0.023 µg · cm–3, for voriconazole 0.016 µg·cm–3, for posaconazole 0.006 µg·cm–3 and for caspofungin 0.25 µg·cm–3. Among the isolates tested, 8 were resistant to voriconazole, 3 resistant to posaconazole and 10 resistant to amphotericin B. Conclusions. The examined strains presented different sensitivity to antifungal drugs. The strongest fungicidal activity was found in the case of: posaconazole, voriconazole and amphotericin B. In the atmospheric air there may exist strains of F. culmorum which have natural resistance to some antimycotics.

  18. FEEDING OF GENETICALLY MODIFIED CROPS AND THEIR EFFECT ON THE FATTENING, CARCASS AND QUALITATIVE INDICATORS OF PIGS SKRMOVANIE GENETICKY MODIFIKOVANCH PLODN A ICH VPLYV NA VKRMOV, JATOCN A KVALITATVNE PARAMETRE OPANCH

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    JURAJ MLYNEK

    2013-03-01

    Full Text Available In the experiment we judged the influence of genetically modified plants on the fattening-, carcass-, and pig quality parameters. We have recorded better fattening parameters in the group fed with the GM crops. We recorded statistically provable differences in the number of the test fattening days (30 100 kg, in the lifelong average daily gains, in the test fodder consumption (30 100 kg. We have recorded better carcass indicators in the group fed without the GM plants, which was statistically confirmed in the valuable meaty parts as well as thigh portions. There were no statistically provable differences found out in the meat quality indicators between the groups.

  19. NA44 experiment

    CERN Document Server

    1990-01-01

    General view of NA44 experiment. NA44 is one of the seven experiments (NA44, NA45, NA49, NA50, NA52, WA97/NA57 and WA98) involved in CERN'S Heavy Ion programme which provided evidence for the existence of a new state of matter in which quarks, instead of being bound up into more complex particles such as protons and neutrons, are liberated and roam freely. Theory predicts that this state must have existed at about 10 microseconds after the Big Bang, before the formation of matter as we know it today.

  20. Wybrane problemy wyceny składnikówaktywów i ich ujęcie w sprawozdaniachfinansowych banków

    Directory of Open Access Journals (Sweden)

    Joanna Wielgórska-Leszczyńska

    2010-05-01

    Full Text Available Rachunkowość udostępnia szczegółową i wszechstronną informację o działalności banku. Dla odbiorców najważniejsze są dane o należnościach i depozytach, gdyż to one decydują o kondycji finansowej i płynności banku. Z analizy sprawozdań finan-sowych dwunastu banków, których akcje są notowane na Giełdzie Papierów Warto-ściowych w Warszawie, wynika że nie zawsze są ujawniane wystarczające dane o polityce rachunkowości i zbyt mało miejsca poświęca się należnościom od klien-tów, które stanowią od 30% do 86,8% aktywów. Także nie wskazuje się na fakt, że tylko od 5% do 13,4% aktywów jest finansowanych kapitałami własnymi. Badanie pokazało rozbieżności między bankami w zakresie ujawniania informacji, zastoso-wanych metod wyceny, prezentacji danych w raportach finansowych pod względem ilości i jakości. W najbliższych latach rachunkowość w bankach będzie zmieniała się i rozwijała wraz ze zmianami, jakie są wprowadzane w systemie bankowym. Rozwój ten powinien też iść w kierunku lepszej prezentacji tych składników, które mają zasadniczy wpływ na kondycję i bezpieczeństwo banku. Udostępniane dane powinny być wiarygodne, porównywalne i aktualne oraz podane w sposób syntetyczny (skoncentrowany.

  1. „Skrwawione ziemie” Timothy Snydera. Krytyczne uwagi na temat konstrukcji krajobrazu historycznego

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    Jürgen Zarusky

    2012-12-01

    Full Text Available Timothy Snyder’s "Bloodlands". Critical comments on the construction of historical landscape Jürgen Zarusky's text is an extensive deconstruction of Timothy Snyder's narration presented in Bloodlands. The narration is based on the assumption, that both regimes – Nazi and Soviet – and their extermination practicies were similar. In Bloodlands Stalin's crimes are presented as a form of ethnic extermination. Thus Snyder suggested ideological kinship between both dictators without analysing specific ideologies. Although the author specifies the differences between these two ideologies he does not ask about their significance to the enemy image and extermination practicies. Snyder's narration concentrates excessively on Poland – as the core of “bloodlands”. In the closing chapter of the book Poles are depicted as the actual martyrs of “bloodlands” in Poland, as well as on the territory of the Soviet Union. Yet up to this day there are ethinc gorups – like Sinti and Romany -  who have to fight for the recognition of their tragic experiences as the victims of crimes commited by German authorities. The author also does not mention about the victims of the agressive wars against the Soviet Union. Thus the point of Bloodlands is not to present all the victims of totalitarianism and the war, all the victims from “bloodlands”, but to present only the victims selected by the author.   „Skrwawione ziemie” Timothy Snydera. Krytyczne uwagi na temat konstrukcji krajobrazu historycznego Tekst Jürgen Zarusky'ego to obszerna dekonstrukcja narracji Timothy Snydera zaprezentowanej w książce Skrwawione ziemie. Zasadza się ona na założeniu, że oba reżimy - niemiecki i radziecki - oraz ich praktyki eksterminacyjne były bardzo do siebie zbliżone. W książce przedstawiono stalinowskie zbrodnie masowe jako formę etnicznej eksterminacji. W ten sposób Snyder zasugerował ideologiczne pokrewieństwo między obu dyktatorami, nie

  2. Angelite: Paziteli na vhoda

    Directory of Open Access Journals (Sweden)

    Gerov Georgi

    2009-01-01

    Full Text Available (bugarski Statijata prosledjava ikonografskata evoljucija na izobraženijata na arhangelite Mihail i Gavriil, pomesteni pri vhoda na pravoslavnija hram. Povraten moment v neja e 13 vek. Togava arhangel Mihail započva da se izobrazjava kato voin. S tova apotropejnite mu funkcii namirat adekvaten vizualen izraz. K'm kraja na stoletieto arhangel Gavriil započva da se izobrazjava kato pisar - ikonografija, kojato šče b'de dorazvita i utv'rdena prez 14 vek. Prez postvizantijskata epoha v obraza na Mihail se pojavjavat elementi, koito akcentirat v'rhu roljata mu na psihopomp.

  3. The Application of Modern Techniques and Measurement Devices for Identification of Copper Ore Types and Their Properties / Wykorzystanie nowoczesnych technik i urządzeń pomiarowych do identyfikacji typów rud miedzi i ich właściwości

    Science.gov (United States)

    Krawczykowska, Aldona; Trybalski, Kazimierz; Krawczykowski, Damian

    2013-06-01

    minerałów miedzionośnych oraz rodzajem ich skupień i wpryśnięć. Niezwykle istotne jest właściwe rozpoznanie rudy pod względem petrograficzno-mineralogicznym. Znajomość właściwości przerabianej rudy pozwala na pełniejsze jej wykorzystanie poprzez właściwe prowadzenie i sterowanie procesami, dobór ich parametrów takich m.in. jak: czas mielenia, parametry klasyfikacji, rodzaj odczynników flotacyjnych, czas flotacji. W artykule przedstawiono wyniki przeprowadzonych analiz mikroskopowych, analizy obrazów zdjęć skaningowych oraz procedury wykorzystania otrzymanych informacji do identyfikacji typów rud (zastosowanie sieci neuronowych do rozpoznawania składów litologicznych). W badaniach wykorzystano rudę miedzi, pochodzącą z jednego z zakładów górniczych KGHM Polska Miedź S.A. Pobrane próbki rudy reprezentowały każdy z trzech typów litologicznych występujących w krajowych złożach: węglanową, łupkową oraz piaskowcową. Przeprowadzono ilościową analizę mineralogiczno-petrograficzną przy pomocy mikroskopu optycznego w świetle odbitym, a wyniki przedstawiono w tabelach 1 i 2. Wyniki te określają ilościowo stopień uwolnienia i zrosty dla jednego rodzaju minerału. Pokazano także przykładowe zdjęcia mikroskopowe zgładów poszczególnych typów litologicznych rud oraz próbek proszkowych tych typów (rys. 1 i 2). W kolejnym etapie badań wykorzystano skaningowy mikroskop elektronowy. Zdjęcia morfologii próbek uzyskane z mikroskopu elektronowego (obrazy SEM) były przedmiotem komputerowej analizy obrazu, umożliwiającej mikrostrukturalną klasyfikację ilościową typów rud. Analizowano wszystkie próbki poszczególnych typów litologicznych rudy miedzi: węglanowej, łupkowej i piaskowcowej oraz mieszanki tych typów w trzech klasach ziarnowych: 0÷45 μm, 45÷71 μm i 71÷100 μm. Celem przekształceń wykorzystanych w procedurze komputerowej analizy obrazu jest otrzymanie poprawnie posegmentowanego obrazu binarnego, kt

  4. Selected Properties of Flotation Tailings Wastes Deposited in the Gilów and Żelazny Most Waste Reservoirs Regarding Their Potential Environmental Management / Wybrane Właściwości Odpadów Poflotacyjnych Zdeponowanych W Zbiornikach Gilów I Żelazny Most W Aspekcie Możliwości Ich Zagospodarowania Przyrodniczego

    Science.gov (United States)

    Baran, Agnieszka; Śliwka, Małgorzata; Lis, Marcin

    2013-09-01

    Wastes originating from copper mining, particularly generated during the ore enrichment process constitute a considerable percentage of industrial wastes in Poland, which theoretically are supposed to provide a raw material base but remain wholly unmanaged. Wastes from copper flotation are deposited on the waste dumps which pose a significant eco-toxicological hazard. The paper discussed the results of analysis of selected post-floatation waste properties deposited in the Żelazny Most and Gilów reservoirs from the perspective of their environmental management. Odpady pochodzące z górnictwa miedzi, szczególnie powstające w procesie wzbogacania rudy, stanowią znaczny odsetek odpadów przemysłowych w naszym kraju, które teoretycznie zasilić mają bazę surowcową i w całości pozostają niezagospodarowane. Odpady z procesu flotacji miedzi są deponowane na składowiskach i stanowią zagrożeniem ekologicznym i ekotoksykologicznym dla środowiska przyrodniczego i człowieka. Niekorzystne oddziaływanie składowisk odpadów poflotacyjnych na środowisko to przede wszystkim deformacje terenu, zanieczyszczenia gleb zanieczyszczeń roślinności metalami ciężkimi, oraz zanieczyszczenie wód powierzchniowych i podziemnych. W artykule zostały omówione niektóre właściwości fizykochemiczne oraz ekotoksykologiczne odpadów poflotacyjnych deponowanych w zbiornikach Żelazny Most i Gilów pod kątem ich biologicznego zagospodarowania. Próbki pobranych osadów, po odpowiednim przygotowaniu, poddano ocenie wybranych parametrów fizycznych, analizie chemicznej oraz serii testów ekotoksykologicznych. Właściwości ekotoksykologiczne osadów oceniono przy użyciu baterii biotestów składającej się z dwóch biotestów pracujących na pięciu organizmach (tab. 1). W teście Phytotoxkit do pomiaru toksyczności osadu wykorzystano trzy rośliny: Sorghum saccharatum, Lepidium sativum i Sinapis alba. Mierzonym parametrem było zahamowanie kiełkowania nasion oraz d

  5. Efektite na prostaciklin vo tretmanot na dijabeticnata nefropatija kaj staorci

    Directory of Open Access Journals (Sweden)

    Jasmina Trojacanec

    2006-06-01

    Full Text Available Mikrovaskularnite komplikacii, a pred se dijabeticnata nefropatija, se edni od najteskite komplikacii na dijabetot, od koi vo golema mera zavisi i prognozata na dijabetot kaj ovie pacienti. Etiopatogenezata na ovaa komplikacija e multifaktorijalna i za sega se uste ne kompletno rasvetlena, a vklucuva morfoloski, patolosko-anatomski i biohemiski metabolni narusuvanja. Se smeta deka narusuvanjeto na modularnata funkcija na endoteliumot moze da bide kriticen i inicijalen faktor vo razvojot na dijabeticnite vaskularni komplikacii. Vrz osnova na farmakodinamskite efekti koi sto gi poseduva prostaciklinot (PGI2 i negovite analozi, se smeta deka istite moze da bidat korisni vo tretmanot na dijabeti~nata nefropatija. Osnovna cel na ovaa studija be{e da se procenat efektite na prostaciklin (PGI2 vo tretmanot na dijabeticnata nefropatija, eksperimentalno predizvikana so streptozocin. Kaj normotenzivni staorci od sojot Wistar, eksperimentalno bese induciran najprvin dijabet so ednokratna i.p. administracija na streptozocin (STZ, a kako komplikacija na dijabetot i jasni znaci i simptomi na dijabeticna nefropatija (proteinurija, zgolemeno serumsko nivo na urea i kreatinin, poliurija, zgolemena aktivnost na NAG vo mockata. Tretman so prostaciklin (p.o. vo doza od 0.1 mg/kg /t.t./den, vo tekot na 4 nedeli, dovede do signifikantno namaluvanje na simptomite i znacite na bubreznite ostetuvanja, vo odnos na grupata zivotni koi ne primaa prostaciklin. Vrz osnova na dobienite rezultati moze da se zakluci deka prostaciklinot moze da ima znacajna uloga vo tretmanot na dijabeticnata nefropatija, eksperimentalno inducirana so streptozocin.

  6. A serendipidade na medicina e na anestesiologia

    OpenAIRE

    Vale,Nilton Bezerra do; Delfino,José; Vale,Lúcio Flávio Bezerra do

    2005-01-01

    JUSTIFICATIVA E OBJETIVOS: Neste trabalho foram examinados mais de uma centena dos mais felizes acoplamentos de uma mente brilhante com a sorte benfazeja (serendipidade), através da releitura das mais relevantes histórias sobre invenções e descobertas relacionadas à ciência (n = 46), à Medicina (n = 46) e à Anestesiologia (n = 16). CONTEÚDO: Conceito de serendipidade; exemplos célebres de serendipidade em Ciência e Tecnologia; serendipidade na pesquisa e prática médicas; serendipidade na Anes...

  7. Medyczny aspekt legalizacji miękkich narkotyków – zagrożenie czy szansa na skuteczne leczenie?

    OpenAIRE

    Habib, Amalia

    2016-01-01

    Obecnie temat medycznego zastosowania marihuany poruszany jest publicznie częściej niż w ubiegłych latach. Najnowsze badania kliniczne potwierdzają leczniczy aspekt jej działania na organizm człowieka w walce z różnymi chorobami, które dotąd nie były możliwe do wyleczenia lub choćby do zmniejszenia ich wyniszczających skutków. Na świecie kolejne kraje dopuszczają obrót konopiami, albo całkowicie, albo jako quasi-legalizację. Polski system prawny nie dopuszcza obecnie wariantu l...

  8. International Conference on Harmonisation; Electronic Transmission of Postmarket Individual Case Safety Reports for Drugs and Biologics, Excluding Vaccines; Availability of Food and Drug Administration Regional Implementation Specifications for ICH E2B(R3) Reporting to the Food and Drug Administration Adverse Event Reporting System. Notice of Availability.

    Science.gov (United States)

    2016-06-23

    The Food and Drug Administration (FDA) is announcing the availability of its FDA Adverse Event Reporting System (FAERS) Regional Implementation Specifications for the International Conference on Harmonisation (ICH) E2B(R3) Specification. FDA is making this technical specifications document available to assist interested parties in electronically submitting individual case safety reports (ICSRs) (and ICSR attachments) to the Center for Drug Evaluation and Research (CDER) and the Center for Biologics Evaluation and Research (CBER). This document, entitled "FDA Regional Implementation Specifications for ICH E2B(R3) Implementation: Postmarket Submission of Individual Case Safety Reports (ICSRs) for Drugs and Biologics, Excluding Vaccines" supplements the "E2B(R3) Electronic Transmission of Individual Case Safety Reports (ICSRs) Implementation Guide--Data Elements and Message Specification" final guidance for industry and describes FDA's technical approach for receiving ICSRs, for incorporating regionally controlled terminology, and for adding region-specific data elements when reporting to FAERS.

  9. Bolonja na hrvatski način

    OpenAIRE

    Krstović, Jasna

    2009-01-01

    Iako je osnovna značajka obrazovnog sustava Republike Hrvatske horizontalna i okomita protočnost, ova se značajka još uvijek ne odnosi na obrazovanje odgajatelja. No u posljednje vrijeme događaju se pomaci i kvalitativne promjene koje su zahvatile i sustav obrazovanja hrvatskih odgajatelja.

  10. Ich spreche anders, aber das ist auch deutsch: línguas em conflito em uma escola rural localizada em zona de imigração no sul do Brasil Ich spreche anders, aber das ist auch deutsch: languages in conflict in a rural school located in an immigration area in the south of Brazil

    Directory of Open Access Journals (Sweden)

    Maristela Pereira Fritzen

    2008-12-01

    Full Text Available O bilingüismo/multilingüismo como fenômeno social ainda é pouco reconhecido no cenário brasileiro, apesar de o tema ter conquistado espaço na academia. Em termos gerais, considera-se o Brasil um país monolíngüe, onde se fala apenas o português brasileiro. Há, no entanto, vários contextos de línguas minoritárias (grupos indígenas, grupos de imigrantes, zonas de fronteira, comunidades de surdos em que o uso de várias línguas é a regra. Nesses contextos sociolingüisticamente complexos há relações assimétricas e de conflito entre a língua hegemônica e as línguas minoritárias, em geral estigmatizadas. O presente estudo, parte dos resultados de uma pesquisa etnográfica, focaliza o conflito lingüístico presente em uma escola rural localizada numa comunidade bilíngüe/multilíngüe em zona de imigração alemã no sul do país, onde, ainda hoje, as crianças aprendem em casa a língua de herança, empregada em âmbito familiar e social. Com suporte teórico predominantemente vindo do bilingüismo visto de uma perspectiva social e dos Estudos Culturais, o objetivo principal deste artigo é problematizar a situação de contato/conflito lingüístico existente na região alvo da pesquisa e sua interface com questões de identidades construídas nos discursos hegemônicos. Além disso, discute-se como esses conflitos emergem nas relações interacionais entre os professores e entre alunos e professores, dentro da instituição escolar. Os registros sugerem que o bilingüismo da comunidade penetra na escola e que os conflitos lingüísticos e identitários ganham ainda mais força nas interações sociais entre os sujeitos que ali convivem.Bilingualism/multilingualism as a social phenomenon is still little recognized in the Brazilian scenario, despite it has gotten space in the academy. Usually, Brazil is seen as a monolingual country, where the Brazilian Portuguese is the only language spoken. There are, however, contexts of

  11. Ich bin ein Unternehmer / Lasse Lehis

    Index Scriptorium Estoniae

    Lehis, Lasse, 1972-

    2006-01-01

    FIE-de sotsiaalmaksu tõstmisest. Lisatud MTA pressiteated: Pau, Aivar. FIE-d on tööjõustruktuuris madalaima taseme sotsiaalmaksu tasujad. Plakk, Liis. Maksuhaldur juhib tähelepanu riskidele tööandja survel FIE-ks astumisel. Lisatud ka ETTK pressiteated: Kriis, Tarmo. Tööandjate keskliit toetab maksuameti seisukohta FIE-de osas. Kriis, Tarmo. Tööandjate keskliit: maksumaksjate liit kaitseb maksudest kõrvale hoidmist. Kriis, Tarmo. Tööandjate keskliit kiidab sotsiaalmaksu miinimummäära kiiret tõstmist. Lisatud BNS uudis: Maksumaksjad on sotsmaksu miinimummäära kiire tõstmise vastu. Lisatud ka EML kiri Riigikogu rahanduskomisjonile: Varend, Õnneli. Ettepanekud sotsiaalmaksuseaduse muutmise seaduse eelnõu kohta. Lisatud: Seaduseelnõu Riigikogus : sõnavõtud sotsiaalmaksuseaduse muutmise seaduse eelnõu 1032 teisel lugemisel Riigikogus

  12. I-Ching of acid rain

    Energy Technology Data Exchange (ETDEWEB)

    Huber, P.

    The yin/yang of I Chin philosophy can describe the acid/alkali balance and the development of acid rain concerns. The author describes the science of sulfur; the chemistry, transport, and ecological impacts as it moves from coal mine to ocean. He then addresses the regulatory options for reducing sulfur emissions or mitigating their environmental impacts at various stages of the coal-sulfur cycle. He sees no fair conclusion because the scientific community is still unwilling to reach a consensus on the widespread ecological risks and because cost-benefit balancing is neither neutral nor objective. If we conclude that a new regulatory initiative is in order, we should recognize that there are better and worse ways of implementing it. Long-term solutions lie in the aggressive promotion of cleaner coal and noncoal technologies. 3 references, 4 figures.

  13. Ich bin ein Unternehmer / Lasse Lehis

    Index Scriptorium Estoniae

    Lehis, Lasse, 1972-

    2006-01-01

    FIE-de sotsiaalmaksu tõstmisest. Lisatud MTA pressiteated: Pau, Aivar. FIE-d on tööjõustruktuuris madalaima taseme sotsiaalmaksu tasujad. Plakk, Liis. Maksuhaldur juhib tähelepanu riskidele tööandja survel FIE-ks astumisel. Lisatud ka ETTK pressiteated: Kriis, Tarmo. Tööandjate keskliit toetab maksuameti seisukohta FIE-de osas. Kriis, Tarmo. Tööandjate keskliit: maksumaksjate liit kaitseb maksudest kõrvale hoidmist. Kriis, Tarmo. Tööandjate keskliit kiidab sotsiaalmaksu miinimummäära kiiret tõstmist. Lisatud BNS uudis: Maksumaksjad on sotsmaksu miinimummäära kiire tõstmise vastu. Lisatud ka EML kiri Riigikogu rahanduskomisjonile: Varend, Õnneli. Ettepanekud sotsiaalmaksuseaduse muutmise seaduse eelnõu kohta. Lisatud: Seaduseelnõu Riigikogus : sõnavõtud sotsiaalmaksuseaduse muutmise seaduse eelnõu 1032 teisel lugemisel Riigikogus

  14. Uczelnia na zagranicznym rynku edukacyjnym – strategia internacjonalizacji szkoły wyższej

    Directory of Open Access Journals (Sweden)

    Andrzej Szromnik

    2014-03-01

    Full Text Available Cel: Wyjaśnienie założeń i warunków realizacyjnych internacjonalizacji uczelni jako strategicznego kierunku jej rozwoju, a ponadto przedstawienie uniwersalnych scenariuszy strategicznych ekspansji uniwersytetu za granicą oraz determinantów sukcesu. Metodologia: Artykuł ma charakter koncepcyjny i opiera się na diagnozie oraz analizie na rynku usług edukacji uniwersyteckiej w Polsce. W wyniku studiów literatury specjalistycznej wyodrębniono główne zjawiska warunkujące funkcjonowanie i kierunki zmian szkolnictwa wyższego stanowiące ogólne tło rozważań i projektów szczegółowych. Wnioski: Autor wskazuje strategie uwarunkowania i procedury decyzyjne ekspansji uniwersytetu na zagraniczne rynki edukacji na poziomie wyższym. Akcentuje główne szanse i zagrożenia z tytułu działalności uczelni za granicą. Propozycje mają nie tylko charakter poznawczy, ale także mogą być podstawą ich aplikacji w realiach polskich uczelni. Oryginalność: Działalność uczelni zagranicznych na rodzimym rynku edukacyjnym jest zjawiskiem występujących w wielu krajach. W artykule zaproponowano koncepcję strategii internacjonalizacji uniwersytetu w jej wariancie ogólnym wraz ze szczegółową procedurą analityczno-decyzyjną. W piśmiennictwie fachowym ten aspekt rozwoju uczelni nie został rozwinięty zgodnie z założeniami marketingu międzynarodowego.

  15. At NA2

    CERN Multimedia

    1977-01-01

    One of the NA2 calorimeter sections is moved in. The NA2 calorimeter was divided in two halves, to the left and the right of the beam, each half consisting of sheets of passive high Z material interleaved with blades of plastic scintillators. The photo shows on the right, the upstream 'electron' module with eleven lead plates for a total radiation length of 20.

  16. Dependability issues in designing warehouse facilities and their functional areas / Zagadnienia niezawodności w projektowaniu magazynów i ich obszarów funkcjonalnych magazynów

    Directory of Open Access Journals (Sweden)

    Lewczuk Konrad

    2016-10-01

    Full Text Available Niezawodność obiektu magazynowego wynika z niezawodności jego obszarów funkcjonalnych i wpływa na niezawodność całego łańcucha dostaw. Aspekty niezawodnościowe pracy magazynu powinny być uwzględniane na etapie projektu, jednakże jest to trudne ze względu na złożoność tych systemów oraz zmienność struktury jakościowej i ilościowej strumieni materiałów na wejściach. Aktualnie stosowane procedury projektowania obiektów magazynowych uwzględniają klasyczne miary niezawodności jako kryterium oceny rozwiązania jedynie w dużym uproszczeniu. W artykule podjęto próbę usystematyzowania podstawowych zagadnień badawczych związanych z niezawodnością magazynów będących elementami łańcuchów dostaw, a jednocześnie obiektami technicznymi. Na tej podstawie możliwe będzie wyspecyfikowanie miar niezawodności możliwych do określenia w oparciu o typowe parametry obiektu magazynowego. Pozwoli to na uogólnienie modelu do oceny niezawodności procesu magazynowego.

  17. ETAŽNA LASTNINA S POUDARKOM NA ZVEtL

    OpenAIRE

    Cvetko, Tadej

    2014-01-01

    Etažna lastnina je lastnina posameznega dela zgradbe in solastnina na skupnih delih, ki služijo vsem ali nekaterim posameznim delom zgradbe. Etažna lastnino na območju Republike Slovenije je uvedel Zakon o lastnini na delih stavbe kot odgovor na potrebo po hitri nacionalizaciji stanovanj in odrazu doslednega uvajanja osnovne ideje takratnega socialističnega duha t.j. družbene lastnine. Slovenija kot mlada demokratična država je ob tranziciji iz socialističnega v demokratični sistem poskušala ...

  18. NAKUPOVANJE NA SPLETU

    OpenAIRE

    Visenjak, Monika

    2013-01-01

    Nakupovanje na spletu je prihodnost poslovanja. Za podjetja pomeni manjše stroške, lažje prilagajanje tržnim pogojem. Hitreje lahko razvijajo odnose in analizirajo uporabnike, saj jim je dan dostop o nakupnih podatkih uporabnika. Za potrošnike je nakupovanje na spletu možnost hitrega, preprostega in učinkovitega nakupovanja od doma ali pisarne. Pomembno je, da se seznanijo z vsemi informacijami in pogoji spletnih trgovin, saj se lahko le tako izognejo nezadovoljstvu ob nakupu v spletni trgovi...

  19. Riso na epilepsia

    Directory of Open Access Journals (Sweden)

    Edymar Jardim

    1967-06-01

    Full Text Available São estudados três casos de síndrome convulsiva temporal, com manifestações concomitantes de riso na sua fase inicial. As características principais foram a imotivação e á incoercibilidade do riso. Esses sintomas desapareceram com o uso de anticonvulsivantes.

  20. The NA48 experiment

    CERN Multimedia

    1995-01-01

    The NA48 experiment is designed to study the Charge-Parity (CP) violation. CP violation is observed in certain very rare decays. Its study is important in understanding Nature's preference of matter over antimatter, which resulted in asymmetry soon after the Big Bang, creating a matter-dominated Universe.

  1. Biotecnologia na agricultura

    Directory of Open Access Journals (Sweden)

    Helaine Carrer

    2010-01-01

    Full Text Available A expectativa de o crescimento populacional atingir 9 bilhões de habitantes em 2050 em adição às questões da sustentabilidade e do aquecimento global nos desafiam a aumentar a oferta de alimentos. Uma metodologia alternativa que contribua para a redução do impacto desse cenário envolve a biotecnologia, que, nas últimas décadas, trouxe marcantes oportunidades tecnológicas na agricultura, resultando em relevante desenvolvimento na obtenção de novas variedades de plantas, na melhoria da qualidade de diversos alimentos e atualmente também na bioenergia. As técnicas biotecnológicas envolvendo os marcadores moleculares, a genômica e a transformação genética estão transformando a agricultura e são discutidas neste artigo.The expected population growth to reach 9 billion by 2050 in addition to issues of sustainability and global warming challenges us to increase the supply of food. An alternative approach to help reducing the impact of this scenario involves biotechnology which in recent decades has brought remarkable technological opportunities in the agriculture that resulted in relevant development in obtaining new plant varieties, improved quality of different foods, and now also in bioenergy. The biotechnology techniques involving molecular markers, genomics and genetic transformation are transforming agriculture and will be discussed in this article.

  2. TECHNICAL ANALYSIS BY THE JAPANESE CANDLES METHOD ON THE EXAMPLE OF AGRICULTURAL MARKETS ANALIZA TECHNICZNA METODA SWIEC JAPONSKICH NA PRZYKLADZIE RYNK ROLNYCH

    Directory of Open Access Journals (Sweden)

    ANNA JAKUBCZAK

    2013-03-01

    Full Text Available The key goal of work was to study of basic information possibilities of the Japanese Candles method and to present its usefulness to make decisions on agricultural markets. The method is a result of the evolution of methods of technical analysis, which lasted for centuries. The usefulness of this method to make decisions is high, but significantly affect have the ability to interpret the observed signals and taking into account the specificities of agricultural markets.Celem opracowania bylo zbadanie podstawowych mozliwosci informacyjnych metody swiec japonskich oraz przedstawienie jej przydatnosci do podejmowania decyzji na rynkach rolnych. Zaprezentowano zwiezla ewolucje metod analizy technicznej oraz scharakteryzowano podstawowe narzedzia metody swiec japonskich, takie jak objecie bessy i hossy, pojedyncze swiece i ich formacje dajace sygnal do wycofania z rynku, doji , luki oraz formacje kontynuacji trendu.

  3. Strategie przedsiębiorstwa prasowego w XXI wieku (internalizacja oraz obecność na rynku nowych technologii

    Directory of Open Access Journals (Sweden)

    Anita Uchańska

    2011-05-01

    Full Text Available Specyfika mediów polega na tym, że z jednej strony odgrywają szczególną rolę w systemie społecznym i politycznym, kształtując opinie społeczeństwa i biorąc udział w dyskusji na istotne tematy, z drugiej strony funkcjonują na zasadzie rynkowej. Z ekonomicznego punktu widzenia przedsiębiorstwa działające w branży medialnej prowadzą działalność gospodarczą nastawioną na zysk. Ich zadanie nie polega więc tylko na dostarczeniu społeczeństwu informacji i rozrywki, ale także na sprostaniu ostrej konkurencji na rynku. Przedsiębiorstwa medialne funkcjonują zatem na dwóch rynkach, będących podstawowymi źródłami ich przychodów – pierwszym z nich jest rynek odbiorców, czyli czytelników, słuchaczy, widzów, użytkowników Internetu czy nowych mediów, z drugiej zaś rynek reklamowy. Efektem ich działalności są dualne produkty medialne, przeznaczone dla odbiorców (treść oraz dla reklamodawców (powierzchnia reklamowa. Szczególnym typem przedsiębiorstwa medialnego jest wydawnictwo prasowe, które ze względu na obecną trudną sytuację na rynku prasy musi znaleźć właściwą formę działalności, aby odpowiedzieć na wyzwanie także ze strony Internetu oraz coraz bardziej popularnych nowych mediów. Dotychczasowy model działalności przedsiębiorstwa prasowego polegał przede wszystkim na wydawaniu prasy drukowanej, a jego rozwój obejmował poszerzanie portfolio o nowe tytuły i unowocześnianie procesów biznesowych oraz rozbudowę zaplecza produkcyjnego, a także inwestowanie w inne media (przy uwzględnieniu ograniczeń wynikających z przepisów prawa. Dodatkową możliwością była ekspansja zagraniczna, w postaci sprzedaży licencji, tworzenia wspólnych przedsięwzięć z lokalnym wydawcą lub zakładanie własnych spółek na obcych rynkach. Internacjonalizacja oraz koncentracja wertykalna i horyzontalna przyczyniły się do powstania konglomeratów medialnych, o dużym znaczeniu mi

  4. O JORNALISTA NA PESQUISA E NA ARTE

    Directory of Open Access Journals (Sweden)

    Beatriz Marocco

    2013-06-01

    Full Text Available O jornalista tem sido objeto das artes e das ciências. Nesta incisão no tema do painel “Configurações e perspectivas da pesquisa em jornalismo no Brasil em diálogo com os estudos latinoamericanos em jornalismo”, realizado no Encontro Nacional da Sociedade Brasileira de Pesquisadores em Jornalismo/SBPJor (Curitiba, 10/11/2012, reconheci que o âmbito acadêmico projeta dois tipos de ação: em rede de pesquisadores de diferentes países e regiões do mundo, com participação de países da América Latina, na pesquisa colaborativa e em projetos de investigação com outras bases de colaboração. Ambas as modalidades dialogam com a produção do cinema e da literatura – que visibiliza a grande potência do profissional para tramas e tensões. 

  5. Importance of automatic threshold for image segmentation for accurate measurement of fine roots of woody plants / Význam automatického prahovania na obrazovú segmentáciu pre presné merania jemných koreňov drevín

    Directory of Open Access Journals (Sweden)

    Surový Peter

    2014-12-01

    Full Text Available Jemné korene sú považované za kľúčové orgány zabezpečujúce prežitie rastliny, jej rast a produkciu. Merania jemných koreňov sú ľahko a pohodlne vykonávateľné pomocou digitálneho obrazu. Popisné veličiny ako plocha koreňov, ich povrch, celková dĺžka či hrúbková štruktúra sa dajú získať z digitálneho obrazu. Analýza digitálneho obrazu pozostáva z niekoľkých krokov, z ktorých každý predstavuje potenciálny zdroj chyby merania. V tomto článku sa zameriavame na automatickú segmentáciu prahovaním a jej vplyv na veličiny získavané z digitálnych skenov jemných koreňov korkového duba (Quercus suber L.. Porovnávame 16 rôznych prahovacích metód a ich správnosť v porovnaní s binárnymi obrazmi vytvorenými ľudským hodnotiteľom. Zistili sme, že niektoré prahovacie metódy dávajú lepšie výsledky ako ostatné v odhade plochy koreňov, ale pred odhad dĺžky koreňov je poradie metód podľa ich správnosti len mierne odlišné

  6. The Impact of Propeller on Aerodynamics of Aircraft / Wpływ Śmigła Na Aerodynamikę Samolotu

    Directory of Open Access Journals (Sweden)

    Zalewski Wiesław

    2015-09-01

    Full Text Available W pracy przedstawiono analizę numeryczną wpływu pracujących śmigieł na aerodynamikę samolotu na przykładzie dwusilnikowego, bezzałogowego samolotu o napędzie elektrycznym. Analiza koncentrowała się głównie na symulacji wzajemnego oddziaływania układu skrzydło-śmigło samolotu. Badano i porównywano trzy konfiguracje: samolot bez śmigieł, samolot ze śmigłami pchającymi i samolot ze śmigłami ciągnącym. Dla każdej konfiguracji wyznaczono rozkłady współczynników aerodynamicznych wzdłuż rozpiętości skrzydła oraz ich globalne wartości dla całego samolotu. Obliczenia wykonano za pomocą programu Fluent z implementacja modelu śmigła opartą na Teorii Elementu Łopaty.

  7. Vaginose Bacteriana na Colpocitologia

    OpenAIRE

    Consolaro,Márcia Edilaine Lopes; Suzuki, Linda Emiko

    2008-01-01

    A flora vaginal representa um ecossistema dinâmico influenciado por fatores diversos, existindo mecanismos desconhecidos que alteram esta flora, desencadeando distúrbios como vaginoses bacterianas. Este trabalho teve como objetivo avaliar a incidência de vaginoses bacterianas detectadas por colpocitologia na população atendida pelo Setor de Citologia Clínica do Laboratório de Ensino e Pesquisa em Análises Clínicas (LEPAC) da Univers...

  8. Preparing for NA4

    CERN Multimedia

    1977-01-01

    Here, in one of the EF workshop, Albert Duchêne works on a pretty piece of mechanics. A few others await to be attended on the left. There are indications that the pipes were meant to house the carbon target (subdivided in eight sections) to be installed inside the toroid magnet of the NA4 experiment. The external strips were designed to possibly correct the magnetic field (???).

  9. Ústav geotechniky SAV na prelome tisícroèí

    Directory of Open Access Journals (Sweden)

    Krúpa Víazoslav

    2002-03-01

    Full Text Available Ústav geotechniky SAV vznikol na základe uznesenia Predsedníctva SAV zo dòa 10.11.1956, s úèinnosou od 1.1.1957. Jeho pôvodný názov bol Laboratórium baníctva SAV v Bratislave. Laboratórium, ktoré predsta-vovalo budúci základ ústavu, bolo v tom istom roku preložené do Košíc. Spoèiatku pôsobilo v priestoroch Baníckej fakulty VŠT a od r. 1961 v novopostavenej budove na Watsonovej ulici. Tu sídli dodnes, aj keï poèas 45 tich rokov sa na jej vstupe menili názvy: Ústav baníctva SAV (1960, Ústav vlastností hornín SAV (1967, Banícky ústav SAV (1975 a Ústav geotechniky SAV (1994. Od 1.1.1993 funguje ústav ako organizácia s príspevkovou formou hospodárenia.Poèas èinnosti ústavu tu pôsobili také významné osobnosti slovenskej vedy, ako napr. akademik Tibor Kolbenheyer, prof. Dr.hc.Dr.Ing. František Špaldon, DrSc., èlen korešpondent SAV, prof. Ing. ¼udovít Kovaniè, DrSc., prof. RNDr. Klára Tkáèová, DrSc., prof. Ing. Félix Sekula, DrSc., RNDr. Jozef Kupka, DrSc., prof. Gejza Dunay, DrSc., prof. Ing. Baltazár Frankoviè, DrSc., plk. prof. Ing. TobiᚠLazar, DrSc., doc. MUDr. Bernard Gomboš, CSc., Ing. Vincent Mihalík, CSc. a ïalší.Ústav geotechniky SAV v Košiciach je pod¾a Zriaïovacej listiny (è. 196/0214/95 zo dòa 23.3.1995, doplnenej dòa 6.5.1997 zameraný na „základný výskum v oblasti kontinuálneho porušovania horninového masívu a skúmanie stability podzemných diel a objektov, transportu energie a hmoty v procese dezintegrácie horniny; základný výskum zákonitostí tvorby tuhých disperzií a modifikácie ich vlastností fyzikálnymi, mechanickými, chemickými a biotechnologickými postupmi; kvalitatívne a kvantitatívne hodnotenie interakcie fáz pri tvorbe disperzných sústav a pri ich šírení v pracovnom a životnom prostredí. Ústav sa cie¾ovo orientuje na využitie teoretických poznatkov z uvedených oblastí, na rozpracovanie špièkových technológií v

  10. A epilepsia na neurocisticercose

    Directory of Open Access Journals (Sweden)

    Luís Marques-Assis

    1972-12-01

    Full Text Available Foram estudados 131 casos de epilepsia com etiologia cisticercótica comprovada. A idade variou de 2 a 68 anos; 75 pacientes eram de sexo masculino e 56 de sexo feminino; 117 eram brancos, 10 pardos, três pretos e um amarelo. A idade de início da doença predominou na primeira década. O estudo foi feito em relação ao tipo de epilepsia, ao tempo decorrido após a primeira crise, à freqüência das crises e ao eletrencefalograma relativamente às epilepsias em geral. Investigação foi feita também em relação à cefaléia, aos achados neurológicos, liquóricos, radiológicos simples e contrastados e anátomo-patológicos. A análise dos resultados permitiu aos autores as seguintes conclusões: 1 No grupo de neurocisticercose o início da doença predominou na primeira e a partir da quarta década em relação às epilepsias em geral. 2 Dentre as manifestações clínicas predominaram as formas convulsivas da doença (61%, sendo as crises bravas-jacksonianas as menos freqüentes (4%; quando comparadas com as epilepsias em geral, verifica-se incidência menor das convulsões generalizadas na neurocisticercose. 3 Quanto ao tempo de doença, verifica-se predomínio das formas de duração mais curta (um ano ou menos na neurocisticercose. 4 A severidade da epilepsia, traduzida pela freqüência das crises, foi menor no grupo com neurocisticercose. 5 Excluídos os casos com anormalidades eletrencefalográficas contínuas, foram encontrados maiores índices percentuais de EEG normal na neurocisticercose que nas epilepsias em geral. 6 A cefaléia estava presente em 68% dos casos, assumindo caráter paroxístico na maior parte (78%; em 67% dos casos com cefaléia paroxística não havia concomitantemente sinais de hipertensão intracraniana; nos casos com cefaléia contínua, em apenas dois (13% esses sinais não estavam presentes. 7 Na maior parte dos casos (62% as manifestações epilépticas se apresentaram isoladamente, sem sinais neurol

  11. Założenia rekreacji terapeutycznej i jej rola na podstawie badań przeprowadzonych w wakacyjnym ośrodku rekreacyjnym Barretstown dla dzieci cierpiących na choroby przewlekłe i zagrażające życiu

    Directory of Open Access Journals (Sweden)

    Joanna Kondracka

    2013-03-01

    Full Text Available Wraz z postępem medycyny maleje liczba dzieci umierających na poważne choroby somatyczne, takie jak nowotwory, białaczka, choroby układu odpornościowego. Jednocześnie wzrasta liczba dzieci, które latami żyją z poważną, prze‑ wlekłą chorobą i na co dzień borykają się ze skutkami ubocznymi długoterminowego leczenia, niemożnością uczest‑ nictwa w normalnych aktywnościach swych rówieśników, ze swoją odmiennością i stałym poczuciem zagrożenia. Do takich właśnie dzieci adresowane są organizowane w USA i w krajach Europy Zachodniej obozy terapeutyczne. Barretstown w Irlandii jest jednym z tego typu ośrodków, gdzie pomaga się dzieciom przy użyciu rekreacji terapeu‑ tycznej (therapeutic recreation, TR. Jest to metoda oparta na procesie przemiany, możliwej, gdy dziecko poczuje się wyjątkowe i niepowtarzalne, bezpieczne i szczęśliwe. U podłoża teoretycznego TR leży wiara w zdolność jednostki do wzbogacenia i zdefiniowania siebie na nowo w oparciu o cztery etapy towarzyszące działaniom: wyzwanie, suk‑ ces, refleksja, odkrycie. Według profesora Petera Kearneya, pediatry z Uniwersytetu w Cork w Irlandii, przemiana, jakiej mogą doświadczać uczestnicy obozów w Barretstown, przypomina proces przejścia znany w literaturze tema‑ tu jako rite of passage. W Barretstown przeprowadzonych zostało kilka badań mających na celu ustalenie skuteczno‑ ści i wpływu TR na poprawę stanu dzieci. Ich rezultaty przedstawia poniższe opracowanie. Istnieje wyraźna potrze‑ ba kontynuacji badań oraz studiów poszczególnych przypadków. Jednocześnie dotychczasowe wyniki i obserwacje psychologów potwierdzają istotną rolę TR we wspieraniu oraz leczeniu dzieci dotkniętych przez poważne chronicz‑ ne choroby somatyczne oraz ich rodzin.

  12. Dyskusja wokół celu sprawozdawczości finansowej opartej na MSSF

    Directory of Open Access Journals (Sweden)

    Edyta Łazarowicz

    2016-07-01

    Full Text Available Celem artykułu jest analiza i ocena propozycji zmian odnośnie do celu sprawozdawczości finansowej opartej na Międzynarodowych Standardach Sprawozdawczości Finansowej (MSSF przedstawionych w komentarzach do projektu Założeń koncepcyjnych sprawozdawczości finansowej (2015. Większość respondentów uważa, że w celu sprawozdawczości finansowej należy zwiększyć znaczenie dostarczania informacji o wypełnieniu funkcji powierniczej przez kierownictwo (stewardship. Ponadto proponują oni przedstawienie definicji stewardship w Założeniach koncepcyjnych oraz wskazanie konsekwencji zmiany celu sprawozdawczości finansowej dla przyszłego tworzenia standardów i dla sporządzania sprawozdań finansowych. Z analizy komentarzy i przeglądu literatury wynika, że cel sprawozdawczości finansowej powinien być zmieniony. Sprawą dyskusyjną pozostaje jednak, czy stewardship powinien być odrębnym celem. Niestety, jest za mało badań dotyczących relacji pomiędzy stewardship i użytecznością decyzyjną. Ich wyniki mogłyby wskazać twórcom standardów rachunkowości potencjalne kompromisy i konflikty między nimi.

  13. na Perua

    Directory of Open Access Journals (Sweden)

    Jorge Carvalho

    1989-01-01

    Full Text Available Antes de se caracterizar como tentativa de ensaio ou de análise a qualquer coisa, o presente artigo tem, antes de mais nada, a pretensão de se constituir uma provocação ao debate acerca da questão do esporte na escola. A provocação parte basicamente do relato da minha experiência pessoal como Secretário da Educação do Município de Aracaju, cargo que exerci no período de 1º de janeiro de 1986 a 27 de janeiro de 1987.

  14. Fractais na arquitectura

    OpenAIRE

    2009-01-01

    Uma forma de inovar na simplicidade, em Arquitectura, é usar a geometria dos fractais. Uma técnica simples de iterativamente chegar a formas fantásticas e muito agradáveis de integrar no desenho de uma obra de arte: sejam edifícios, pontes, jardins, e outros. Vamos abordar o conceito essencial da geometria dos fractais e analisar exemplos da sua aplicação em edifícios e cidades. Para isso faz-se uma introdução ao tema pelos primórdios da geometria fractal referindo exemplos como o Co...

  15. A escola na internet

    OpenAIRE

    Albino, Ayrán Lavra

    2003-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção. O presente trabalho pretendeu analisar o uso do suporte tecnológico do ensino a distância (computador e internet) como elemento complementar do ensino presencial. Procurou-se demonstrar, na fundamentação teórica, que as tendências pedagógicas contemporâneas e as características da tecnologia digital viabilizam esta possibilidade. Operacionalizou-se essa ...

  16. Fractais na arquitectura

    OpenAIRE

    Ganhão, Susana Maria Gouveia Rosado

    2009-01-01

    Uma forma de inovar na simplicidade, em Arquitectura, é usar a geometria dos fractais. Uma técnica simples de iterativamente chegar a formas fantásticas e muito agradáveis de integrar no desenho de uma obra de arte: sejam edifícios, pontes, jardins, e outros. Vamos abordar o conceito essencial da geometria dos fractais e analisar exemplos da sua aplicação em edifícios e cidades. Para isso faz-se uma introdução ao tema pelos primórdios da geometria fractal referindo exemplos como o Co...

  17. Report from NA49

    CERN Document Server

    Gazdzicki, M; Anticic, T; Baatar, B; Barna, D; Bartke, Jerzy; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Brun, R; Buncic, P; Cerny, V; Christakoglou, P; Chvala, O; Cramer, J G; Csató, P; Darmenov, N; Dimitrov, A; Dinkelaker, P; Eckardt, V; Farantatos, G; Filip, P; Flierl, D; Fodor, Z; Foka, P Y; Freund, P; Friese, V; Gál, J; Georgopoulos, G; Gladysz-Dziadus, E; Grebieszkow, K; Hegyi, S; Höhne, C; Kadija, K; Karev, A; Kliemant, M; Kniege9, S; Kolesnikov, V I; Kollegger, T; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; Van Leeuwen, M; Lévai, Peter; Litov, L; Lungwitz, B; Makariev, M; Malakhov, A I; Markert, C; Mateev, M; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Mitrovski, M; Molnár, J; Mrówczynski, S; Pálla, G; Panagiotou, A D; Panayotov, D; Petridis, A; Pikna, M; Pinsky, L; Pühlhofer, F; Reid, J G; Renfordt, R E; Richard, A; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Sann, H; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Stefanek, G; Stock, R; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Trainor, T A; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wetzler, A; Wlodarczyk, Z; Yoo, I K; Zaranek, J; Zimányi, J

    2004-01-01

    The most recent data of NA49 on hadron production in nuclear collisions at CERN SPS energies are presented. Anomalies in the energy dependence of pion and kaon production in central Pb+Pb collisions are observed. They suggest that the onset of deconfinement is located at about 30 AGeV. Large multiplicity and transverse momentum fluctuations are measured for collisions of intermediate mass systems at 158 AGeV. The need for a new experimental programme at the CERN SPS is underlined.

  18. Comprometimento pulmonar na leptospirose

    Directory of Open Access Journals (Sweden)

    Jorge Eduardo Manhães de Carvalho

    1992-03-01

    Full Text Available Em 23 pacientes com leptospirose apresentando comprometimento pulmonar, internados no Hospital Universitário Antônio Pedro da XJFF, Niterói, hemoptise e hemoptóicos foram observados em 21,7% e 30,4%, respectivajnente. Gasometria arterial revelou hipoxemia e hipocapnia na maioria dos casos. Radiografia de tórax em 15 pacientes mostrou comprometimento alveolar em 60%, comprometimento intersticial-reticular em 6%, padrão misto (alveolar e intersticial em20%e ausência de alterações radiológicas em 14%. A necrópsiade 13 pacientes mostrou edema, congestão e hemorragia nos pulmões em 100% dos casos. A hemorragia foi focal em 46% e difusa em 54% dos casos. Houve formação de membrana hialina em 30% e trombos de fibrina em 46% dos pulmões estudados, o que estabelece o diagnóstico da coagulação intravascular disseminada e a ocorrência da síndrome de angústia respiratória na leptospirose.

  19. Laser na medicina: avanços na Oftalmologia

    OpenAIRE

    João Alberto Holanda de Freitas

    2007-01-01

    Entre os grandes avanços tecnológicos dos últimos anos, o laser sem dúvida ocupa lugar de destaque. Desde a construção do primeiro aparelho a laser em 1959, novas aplicações surgem continuadamente. O laser está presente de maneira marcante na pesquisa básica, na indústria e na medicina.

  20. Na Cauda do Cometa

    Science.gov (United States)

    Voelzke, M. R.

    2009-01-01

    Quando viam um cometa, os antigos gregos imaginavam uma estrela com uma vasta cabeleira. Não à toa, a palavra deriva do termo koma, que significa cabelo. Constituídos por fragmentos de gelo e gases, os cometas possuem um núcleo sólido, que pode ter vários quilômetros de diâmetro, e uma cauda que sempre aponta na direção contrária ao Sol, devido aos ventos solares. Graças à aparência de pontos luminosos em movimento (ao contrário de outros astros, que parecem estáticos), esses corpos celestes foram interpretados por diferentes povos com muito misticismo, inspirando mitos tanto de boas-novas como de maus presságios. Conheça algumas dessas histórias:

  1. O real na psicose

    Directory of Open Access Journals (Sweden)

    Maurício Castejón Herrmann

    2004-06-01

    Full Text Available Este artigo discute a noção de real na psicose, a partir das formulações de Lacan sobre o tema, presentes no Seminário 3 - As Psicoses, no Seminário 20 - Mais, Ainda e no texto Televisão. Considerando-se que a concepção de real tem uma indicação clínica, a hipótese que se formula é a de que a noção de real trabalhada no Seminário 20, Mais, Ainda representa uma continuidade da concepção de real desenvolvida no Seminário 3, As Psicoses

  2. NA48 prototype calorimeter

    CERN Document Server

    1990-01-01

    This is a calorimeter, a detector which measures the energy of particles. When in use, it is filled with liquid krypton at -152°C. Electrons and photons passing through interact with the krypton, creating a shower of charged particles which are collected on the copper ribbons. The ribbons are aligned to an accuracy of a tenth of a millimetre. The folding at each end allows them to be kept absolutely flat. Each shower of particles also creates a signal in scintillating material embedded in the support disks. These flashes of light are transmitted to electronics by the optical fibres along the side of the detector. They give the time at which the interaction occurred. The photo shows the calorimeter at NA48, a CERN experiment which is trying to understand the lack of anti-matter in the Universe today.

  3. Leadeship: na effective relationship

    OpenAIRE

    Sergio Roberto Guimarães Pantoja

    2005-01-01

    Resumo: O presente trabalho tem por objetivo analisar a eficácia da liderança em três instituições de ensino superior em São Luís -MA, sendo a instituição A (particular), a B (pública federal) e a C (pública estadual). Adotou-se os estilos de liderança: democrático, autocrático e liberal, baseando-se na Teoria dos Estilos de Kurt Lewin e seus colaboradores e nas qualidades de liderança (objetividade, compreensão dos outros, flexibilidade, comunicação e autoridade), definidas por Uris A.(196...

  4. Raytracing na GPU

    OpenAIRE

    Straňák, Marek

    2011-01-01

    Raytracing je základnou technikou pro vizualizaci trojrozměrných objektů. Cílem práce je demonstrovat možnost implementace sledovaní paprsků pomocí grafického akcelerátoru.  Popíšem základní algoritmus a jeho modifikovanou verzi, která byla implementována pomocí jazyka CUDA C. Výsledný raytracer je optimalizovaný pro dynamické scény. Pro tento účel byla použita akcelerační struktura KD strom, hierarchické obalové tělesa a přenos dat pomocí PBO. Pro realističtější výstupy byla také implementov...

  5. Comprometimento pulmonar na leptospirose

    Directory of Open Access Journals (Sweden)

    Jorge Eduardo Manhães de Carvalho

    1992-03-01

    Full Text Available Em 23 pacientes com leptospirose apresentando comprometimento pulmonar, internados no Hospital Universitário Antônio Pedro da XJFF, Niterói, hemoptise e hemoptóicos foram observados em 21,7% e 30,4%, respectivajnente. Gasometria arterial revelou hipoxemia e hipocapnia na maioria dos casos. Radiografia de tórax em 15 pacientes mostrou comprometimento alveolar em 60%, comprometimento intersticial-reticular em 6%, padrão misto (alveolar e intersticial em20%e ausência de alterações radiológicas em 14%. A necrópsiade 13 pacientes mostrou edema, congestão e hemorragia nos pulmões em 100% dos casos. A hemorragia foi focal em 46% e difusa em 54% dos casos. Houve formação de membrana hialina em 30% e trombos de fibrina em 46% dos pulmões estudados, o que estabelece o diagnóstico da coagulação intravascular disseminada e a ocorrência da síndrome de angústia respiratória na leptospirose.Tostudy thepulmonary complications in leptospirosis case records of 23 such patients admitted at the Hospital Universitário Antônio Pedro, Universidade Federal Fluminense, Niterói, Brasil, were reviewed. Hemoptysis were seen in 21.7% and sputal blood in 30.4% of patients. Arterial gasometry detected hypoxemia and hypocapnia in most cases. Thoracic radiology showed an alveolar pattern in 60% of the patients, alveolo-interstitial in 20%, interstitial in 6%, and in 14% the lungs were considered to be normal Necropsy of 13 cases showed edema, congestion and hemorrhage in the lungs in all cases. Hyaline membrane was found in 30% and fibrin thrombi in 46% of these cases, resulting in a diagnosis of adult respiratory distress syndrome and acute disseminated intravascular coagulation (consumption coagulopathy in leptospirosis.

  6. A ENGENHARIA NA ESCOLA

    Directory of Open Access Journals (Sweden)

    Valéria Pelizzer Casara

    2015-04-01

    Full Text Available Este projeto teve por objetivo principal mostrar às jovens do ensino médio, como as áreas de exatas e de engenharia podem estar inseridas em situações rotineiras por elas vivenciadas e incentivá-las para ingressarem nessas áreas. O projeto foi executado na escola de ensino Médio Nelson Horostecki na cidade de Chapecó, Santa Catarina. Mostrou-se de forma simples que as áreas de exatas e de engenharia têm aplicações práticas nas nossas vidas. No desenvolvimento do projeto, realizaram-se oficinas na escola cujo tema principal abordado foi o processo de fabricação do chocolate, visto que o mesmo é um produto muito apreciado pelas adolescentes. Dentro dessa temática, foram trabalhadas as questões que envolvem conhecimentos das áreas de exatas e de engenharia, mais especificamente a Engenharia Ambiental. O projeto auxiliou na formação cidadã e também na escolha profissional das meninas. Muitas das alunas participantes nunca haviam tido contato direto com alunos graduandos de cursos na área das exatas. Mais ainda, este projeto oportunizou a aproximação da universidade com a comunidade externa. Palavras-chave: Extensão Universitária, Ciências Exatas e Engenharia, Chocolate, Oficinas.   Engineering in the school Abstract: The main objective of this project was to show high school female students how the exact sciences and engineering can be included in their routine situations encouraging them to entering in these areas. The project was carried out at the Nelson Horostecki High School in Chapecó, Santa Catarina State, Brazil. It was showed in a simple manner how exact sciences and engineering have practical applications in our lives. Workshops were conducted in the school during the execution of the project in which the main subject was the chocolate manufacturing process, since chocolate is a product greatly appreciated by the young female people. Within this matter, the activities were performed using the knowledge of

  7. Rezension von: Thomas Martinec, Claudia Nitschke (Hg.: Familie und Identität in der deutschen Literatur. Frankfurt am Main u.a.: Peter Lang Verlag 2009. — Ariane Eichenberg: Familie – Ich – Nation. Göttingen: V&R unipress 2009.

    Directory of Open Access Journals (Sweden)

    Christine Kanz

    2010-06-01

    Full Text Available Die Themen Generation und Familie gehören zu den wichtigsten Sujets literarischer Texte, insbesondere wenn diese die Herausbildung oder die Zerstörung von Identität problematisieren. Ein neuer, von Claudia Nitschke und Thomas Martinec herausgegebener Tagungsband ist der literatur- und kulturwissenschaftlichen Auseinandersetzung mit diesen Themen gewidmet. Sechs Jahrzehnte nach dem Ende des Zweiten Weltkrieges hat vor allem das Genre des Generationenromans Hochkonjunktur, insbesondere Texte der dritten Generation zum Umgang der Großeltern-Generation mit dem Nationalsozialismus. Den Verfasser/-innen dieses neuen, in sich heterogenen Genres wird in der Studie von Ariane Eichenberg allerdings keine allzu große Wirkmächtigkeit bescheinigt. Im Gegenteil nährten die modischen Texte mit den Funden aus der Vergangenheit vor allem das Ich der Erzähler/-innen, deren eigene Gefühle und Selbstvergewisserung in einer von Unsicherheiten geprägten Gegenwart.

  8. Żony XIX-wiecznych zesłańców jako organizatorki życia rodzinnego na Syberii/ Wives of 19 th century deportees as organisers of family life in Siberia

    Directory of Open Access Journals (Sweden)

    BARBARA J Ę DRYCHOWSKA

    2014-01-01

    Full Text Available XIX-wieczne zesłania na Syberię należały do jednych z bardziej bolesnych doświadczeń Polaków tamtej epoki i wpisały się na stałe w polską historię. Za sprawą przede wszystkim literatury romantycznej, a potem także malarstwa, życie zauralskich wygnańców przez długi czas ukazywano jedynie w kontekście martyrologicznym. Dopiero polscy sybiracy, powracający po wielu latach do kraju, sami zaczęli zmieniać ten obraz. W publikowanych jeszcze w XIX wieku ich świadectwach (pamiętnikach,wspomnieniach, dziennikach, listach, znaleźć można interesujące opisy nie tylko codziennych zmagań z trudną rzeczywistością zsyłki, ale również funkcjonowania w wymiarze wspólnoty zesłaczej oraz rodzinnej. Ponieważ prawo rosyjskie zezwalało, aby skazanym na Syberię towarzyszły żony, niektóre z nich dobrowolnie podążały na kattorgę lub osiedlenie wraz z mężem. Większość z nich decydowała się na zabranie ze sobą dzieci. Z chwilą znalezienia się za Uralem podlegały one takim samym rygorom,jak skazani – mogły powrócić do kraju jedynie po odbyciu przez małżonka kary zesałnia lub kiedy on zmarł. Troszczyły się, aby życie rodzinne na wygnaniu niewiele odbiegło od tego na wolności: prowadziły gospodarstwo, wychowywały dzieci, zajmowały się ich kształceniem osobiście lub organizowały tzw. komplety. Przygotowywaływ swoich domach święta kościelne i obchody świąt narodowych, koncerty i teatrzyki dziecięce. Ich rezygnacja z wygodnego życia w kraju i decyzja o syberyjskiej tułaczcu boku męża wpisywały się w romantyczny wizerunek polskiej kobiety–patriotki, ale jednoczenie były wyrazem miłości i poświęcenia na rzecz rodziny.

  9. ICH 患者血清和血肿液中 IL-4、IL-6、IL-8、IL-10的变化研究%Hematoma fluid and serum of patients with acute cerebral hemorrhage about IL-4, IL-6, IL-8, and IL-10 Changes

    Institute of Scientific and Technical Information of China (English)

    赵金安; 白西民

    2016-01-01

    目的:观察急性脑出血(ICH)患者血清和血肿液中 IL-4、IL-6、IL-8、IL-10的变化。方法:选取80例在我院治疗的基底节区脑出血患者,按照发病时间将患者分为5组(发病时间≤6h、6h <发病时间≤12h、12h <发病时间≤24h、24h <发病时间≤72h、3d <发病时间≤7d),检测各组血清和血肿液中 IL-4、IL-6、IL-8、IL-10的含量以及出血量和水肿量;另选取21例健康体检者,检测其血清 IL-4、IL-6、IL-8、IL-10的含量作对照。结果:IL-4、IL-6、IL-8、IL-10在患者静脉血、血肿液中的浓度均显著高于正常对照组,而患者静脉血与血肿液中 IL-4、IL-6、IL-8、IL-10浓度比较,差异无统计学意义。基底节区脑出血患者发病时间≤6h 与正常对照组比较,除 IL-10浓度升高不明显外,IL-4、IL-6、IL-8浓度均明显升高;24h <发病时间≤72h 时,IL-4、IL-6、IL-8浓度与其他各时段比较,以及3d <发病时间≤7d时,IL-10浓度与其他各时段比较,差异均具有统计学意义。各时段出血量和水肿量比较,差异均无统计学意义,出血量和水肿量均在发病时间≤6h至12h <发病时间≤24h 逐渐增大,12h <发病时间≤24h 达到峰值。结论:ICH 患者静脉血、血肿液中 IL-4、IL-6、IL-8浓度可以作为早期检测(≤6h)ICH 的指标,并可通过不同炎症因子的含量变化判断 ICH 患者发病时间,且患者发病一周内周围脑组织出血量和水肿量变化不大。%Objective To observe the changes of IL-4, IL-6, IL-8, IL-10 in serum and hematoma of ICH. Methods 80 cases ICH patients were divided into five groups(<6h, 6-12h, 12-24h, 24-72h, 3-7d). The control group were 21 healthy persons serum. The content of IL-4, IL-6, IL-8, IL-10 in different time were compared and the amount of bleeding and edema. Results IL-4, IL-6, IL-8, IL-10 in patients with venous hematoma fluid concentrations were

  10. Valores na escola

    Directory of Open Access Journals (Sweden)

    Menin Maria Suzana De Stefano

    2002-01-01

    Full Text Available Neste texto pretende-se discorrer sobre valores morais na escola e suas implicações para a formação de professores. Para tanto discutir-se-á, em primeiro lugar, e brevemente, o que são valores morais, ou éticos, e como a escola pode situar-se em relação a eles. Em seguida, serão relatadas algumas observações a respeito de valores de professores e práticas daí decorrentes. São comentados resultados de pesquisa que ilustram a transmissão de valores de forma doutrinal e a educação moral e cívica tal como realizada na ditadura militar, e, por outro lado, a posição relativista e/ou de laissez-faire que certas escolas podem adotar, metodologicamente, sobre a educação em valores. Finalmente, defender-se-á a idéia de que é necessária uma discussão sobre valores pelos diversos membros da escola e uma opção por uma metodologia para ensiná-los, seja os professores, em sua formação inicial e continuada, seja os alunos. A teoria de desenvolvimento moral de Jean Piaget será apresentada como uma referência possível para a educação em valores. Exemplos de situações escolares de conflito de valores entre direção, pais e alunos são discutidas para ilustrar como uma escola pode adotar um procedimento democrático de educação em valores, que se apresenta como um terceiro caminho possível de educação moral nas escolas, além das posições doutrinárias ou relativistas.

  11. Przebieg i znaczenie zajęć arteterapeutycznych dla dziewcząt cierpiących na jadłowstręt psychiczny, hospitalizowanych na oddziale psychiatrii dziecięcej. Doniesienie wstępne

    Directory of Open Access Journals (Sweden)

    Joanna Kondracka

    2014-06-01

    Full Text Available Celem niniejszej pracy była obserwacja i ewaluacja dotychczasowego przebiegu badania nad rolą warsztatów arteterapeutycznych w procesie zdrowienia nastoletnich pacjentek cierpiących na jadłowstręt psychiczny. Od grudnia 2011 roku autorka pracy, psycholog z tytułem plastyka ceramika, prowadzi warsztaty arteterapii na oddziale psychiatrii wieku rozwojowego. Do czerwca 2013 roku w zajęciach wzięło udział 27 pacjentek, spośród których 15 spełniło kryteria włączające do badania. Dziewczęta są badane po przyjęciu na oddział oraz 6 miesięcy po zakończeniu leczenia za pomocą następujących narzędzi: EAT-26 (Eating Attitudes Test, EDI (Eating Disorder Inventory, YSR (Youth Self-Report – jedno z narzędzi z grupy Child Behavior Checklist – oraz KBPK (Kwestionariusz do Badania Poczucia Kontroli. Dodatkowo po ukończeniu cyklu warsztatów arteterapeutycznych pacjentki są proszone o wypełnienie ankiet ewaluacyjnych. Ich dotychczasowe wyniki przedstawiono w załączeniu. Obserwacje zdobyte przez autorkę w przebiegu prowadzenia zajęć arteterapeutycznych oraz wnioski wypływające z ankiet ewaluacyjnych wskazują na zapotrzebowanie na tego typu formę terapii wśród osób hospitalizowanych z powodu jadłowstrętu psychicznego. Na obecnym etapie badań trudno wykazać pozytywny wpływ arteterapii na proces zdrowienia pacjentek. Autorka ma nadzieję, że analiza wyników uzyskanych od ostatecznej liczby badanych umożliwi rzetelną ocenę skuteczności arteterapii w leczeniu jadłowstrętu psychicznego.

  12. Rozw\\'oj bibliotek cyfrowych i repozytori\\'ow elektronicznych na Dolnym Slasku w latach 2004-2008 / Development of Digital Libraries and Electronic Repositories in Lower Silesia in Years 2004-2008

    CERN Document Server

    Moskwa, Krzysztof

    2010-01-01

    In following elaboration were presented digital libraries and electronic repositories operating in Lower Silesia region (of Poland) in years 2004-2008. General description of character and size of their collections was presented, as well as standards and methods of digital collections management and juridical aspects of this management. Potential of usage of digital collections in regional scientific researches was described. ----- W referacie przedstawiono biblioteki cyfrowe i repozytoria elektroniczne funkcjonujace na Dolnym Slasku w latach 2004-2008. Scharakteryzowano og\\'olnie ich zawarto\\'s\\'c i wielko\\'s\\'c, zaprezentowano standardy i systemy zarzadzania kolekcjami cyfrowymi oraz om\\'owiono uwarunkowania prawne towarzyszace zarzadzaniu zasobami cyfrowymi. Wskazano mo\\.zliwo\\'sci wykorzystania kolekcji cyfrowych w badaniach naukowych realizowanych w regionie.

  13. A CORPOREIDADE NA ESCOLA

    Directory of Open Access Journals (Sweden)

    Márcio Xavier Bonorino Figueiredo

    2008-07-01

    Full Text Available Com este estudo, visa-se a investigar como a escola tem construído um corporeidade para a submissão dos estudantes ao sistema de dominação vigente. Propõe-se, também, a descobrir a corporeidade expressa nas brincadeiras, jogos e desenhos das crianças. Realizaram-se observações do espaço escolar de uma sala de aula durante um ano letivo, bem como duas entrevistas com cada uma das crianças de uma turma de 1ª série do 1º grau, em uma escola pública de periferia. Constatou-se que a escola, através de uma série de normas, explícitas ou implícitas, vai construindo uma corporeidade baseada no individualismo, na massificação e nos privilégios de uma minoria. A análise das brincadeiras, jogos e desenhos infantis revelou que estes veiculam valores contrários àqueles impostos pela escola. Em vista disso, elaborou-se uma proposta incipiente de trabalho corporal que tenha nas brincadeiras, jogos e desenhos das crianças o seu ponto de partida para uma práxis transformadora.

  14. O SUBLIME NA MODERNIDADE

    Directory of Open Access Journals (Sweden)

    Martha de Almeida

    2009-03-01

    Full Text Available A obra Uma investigação filosófica sobre a origem de nossas idéias do sublime e dobelo, do sensualista inglês Edmund Burke (1757, data as origens do sublime na Modernidade. Nosublime ocorre é um prazer ligado à dor, um "horror delicioso" que sentimos quando acreditamosque estamos em perigo sem que isso esteja ocorrendo realmente. Em O mundo como Vontade erepresentação Schopenhauer assume as influências que sofreu de Kant no que diz respeito à suainterpretação sobre o belo e o sublime, porém difere dele quanto à natureza dessa impressão. ParaSchopenhauer a experiência estética pressupõe a dissolução da subjetividade num movimento decontemplação das idéias livre do querer imposto pela vontade individual. As idéias deSchopenhauer influenciaram a estética do Nietzsche de O nascimento da tragédia.

  15. A aposta na filosofia

    Directory of Open Access Journals (Sweden)

    Márcio Suzuki

    2011-12-01

    Full Text Available Para Hume, filosofar é uma atividade semelhante às demais ocupações humanas. A decisão que leva à atividade filosófica é menos resultado de uma argumentação teórica do que fruto de um cálculo prático, que é entendido como uma caça ou um jogo. O objetivo deste trabalho será o de mostrar que no jogo filosófico perde quem joga sério demais. A aposta na filosofia tem que passar pelo bom humor e pela diversão: uma resposta a Pascal?For Hume, philosophy is in itself neither more nor less important than other human activities. On the contrary, it can be explained from its resemblance with game and hunting. If one chooses to dedicate himself to philosophy, his decision is not the consequence of logical reasoning, but depends on practical evaluation, which has something to do with gambling. The following text tries to show that in philosophy, like in other games, the loser will be the one who plays too earnestly. The philosophical game requires good humour and some relaxation: Is this a good answer to Pascal's pari?

  16. Bioindication on the basis of benthic diatoms: Advantages and disadvantages of the Polish phytobenthos lake assessment method (IOJ – the Diatom Index for Lakes / Bioindykacja na podstawie okrzemek bentosowych: Mocne i słabe strony polskiej metody oceny jezior na podstawie fitobentosu (IOJ – Indeks Okrzemkowy Jezior

    Directory of Open Access Journals (Sweden)

    Bielczyńska Aleksandra

    2015-12-01

    Full Text Available Wrażliwość okrzemek na presje antropogeniczne (np. eutrofizację lub zakwaszenie wód skutkuje ich szerokim zastosowaniem w bioindykacji. W wielu krajach na świecie podjęto się opracowania lub stosowania opracowanych już indeksów biotycznych opartych na okrzemkach fitobentosowych, służących ocenie stanu wód. Od 2000 roku w krajach członkowskich Unii Europejskiej odbywa się to w ramach wdrażania Ramowej Dyrektywy Wodnej. Wyniki uzyskane przy użyciu polskiej metody oceny jezior na podstawie okrzemek epifitycznych (IOJ - Indeks Okrzemkowy Jezior, znacznie odbiegają od wyników jakie dają pozostałe metody oceny stanu ekologicznego. W niniejszym artykule podjęto się prześledzenia literatury naukowej dotyczącej fitobentosu w bioindykacji w celu zidentyfikowania silnych i słabych stron polskiej metody IOJ oraz wskazania potencjalnych kierunków udoskonalenia metody. Prześledzono literaturę dokumentującą zmienność fitobentosu związaną z jego siedliskiem, zmienność przestrzenną w skali jeziora oraz zmienność w sezonie wegetacyjnym. Przytoczone piśmiennictwo wskazuje na to, że doprecyzowanie wytycznych do procedury poboru prób oraz zwiększenie liczby stanowisk badawczych mogłoby zwiększyć funkcjonalność polskiej metody oceny jezior. Zasugerowano również, że warto podjąć się przetestowania wpływu zmienności sezonowej zespołu fitobentosu na jego wartość bioindykacyjną.

  17. Aktywność słowotwórcza a zjawisko zapożyczeń na przykładzie czasowników dwuaspektowych (w ujęciu polsko-słowackim

    Directory of Open Access Journals (Sweden)

    Halina Mieczkowska

    2015-12-01

    Full Text Available Word formation activity and the phenomenon of loanwords as exemplified by dual aspect verbs (in Polish-Slovakian interlinguality The conducted analysis of dual aspect verbs (based on selected linguistic material and contrasting them with the state observed a quarter or half century ago do not show interdependencies between the existence of the group of genetically foreign dual aspect verbs – which are very limited and virtually relic in Polish but definitely more frequent in Slovakian – and a strong trend for word borrowing. On the contrary, the observed linguistic increase in prefixed oppositional units of perfective aspect indicates that more significant impact on their development and functioning is exerted by the established word formation technique as well as the lexical and grammatical structure of the native language.   Aktywność słowotwórcza a zjawisko zapożyczeń na przykładzie czasowników dwuaspektowych (w ujęciu polsko-słowackim Przeprowadzona analiza czasowników dwuaspektowych (w oparciu o wybrany materiał językowy i ich konfrontacja ze stanem sprzed ćwierć-, a nawet półwiecza nie wykazują wzajemnych zależności pomiędzy funkcjonowaniem w języku – nielicznej, prawie reliktowej w polszczyźnie i zdecydowanie liczniejszej w języku słowackim – grupy genetycznie obcych czasowników dwuaspektowych a silnym nurtem zapożyczeń. Wręcz przeciwnie – obserwowany przyrost językowy prefiksalnych członów opozycyjnych o wartości aspektu dokonanego wskazuje, że większy wpływ na ich rozwój i funkcjonowanie wywierają utarta technika słowotwórcza i struktura leksykalno-gramatyczna języka rodzimego.

  18. Ulogata na endoetelin-1 vo razvojot na dijabeticna nefropatija inducirana so streptozocin

    Directory of Open Access Journals (Sweden)

    Jasmina Trojacanec

    2006-06-01

    Full Text Available Dijabeticnata nefropatija pretstavuva edna od hronicnite mikrovaskularni komplikacii na dijabetot, so multifaktorijalna i ne do kraj rasvetlena etiopatogeneza. So ogled na toa sto kaj pacientite so dijabet, osobeno kaj onie so dijabeticna nefropatija, se najdeni zgolemeni vrednosti na endotelin-1, se pretpostavuva deka istiot moze da ima znacajna uloga vo razvojot na dijabeticnata nefropatija. Osnovna cel na nasata studija bese da se detektiraat promenite vo plazmatskoto nivo na endotelin-1 po eksperimentalno induciran dijabet, i dijabeticna nefropatija kaj staorci so streptozocin. So ogled na dobro poznatite efekti na AKE-inhibitorite, vo ovaa studija go ispituvavme i vlijanieto na enalapril (AKE inhibitor na plazmatskite koncentracii na endotelin-1, kako i negovite efekti vo tretmanot na dijabeti~na nefropatija. Ednokratnata i.p. administracija na streptozocin (STZ predizvika signifikantno zgolemuvanje na plazmatskite koncentracii na endotelin-1, proprateni so jasno izrazeni simptomi i znaci na dijabeticna nefropatija (mikroalbuminurija, zgolemeni urinarni vrednosti na N-acetyl-fl-D-glucosamidase, zgolemeni serumski koncentracii na urea, poliurija. Cetiri nedelniot tretman so enalapril dovede do signifikantno namaluvanje na plazmatskite koncentracii na endotelin-1 i do podobruvanje na simtomite i znacite na dijabeticnata nefropatija. Dobienite rezultati potvrduvaat deka endotelin-1 moze da ima znacajna uloga vo razvojot i progresijata na dijabeticnata nefropatija, a AKE inhibitorite, odnosno enalapril, mozat da ja ublazat i usporat progresijata na dijabeticnata nefropatija

  19. Dificuldades da aprendizagem na leitura

    OpenAIRE

    Nascimento, Solange Oliveira; Trugillo, Edneuza Alves

    2011-01-01

    Este presente artigo propôs verificar os fatores que influenciam no desenvolvimento da aprendizagem na leitura dos alunos da 4º ano no Ensino Fundamental na Escola Municipal Armando Dias no município de Sinop/MT, cujo tema é dificuldade da aprendizagem na leitura. O objetivo do trabalho foi investigar as relações interpessoais em sala de aula e de que forma a professora introduz a leitura nos conteúdos dados aos alunos. Como fundamentação teórica, recorremos a vários autores, entre eles: Enri...

  20. SPOLNO NADLEGOVANJE NA DELOVNEM MESTU

    OpenAIRE

    Rubič, Gašper

    2016-01-01

    V diplomskem delu smo v uvodu predstavili problem spolnega nadlegovanja na delovnem mestu in predstavili podjetje TEKSTIL d.d. V nadaljevanju smo z anketo raziskali, ali problem spolnega nadlegovanja na delovnem mestu v obravnavanem podjetju obstaja in če, kako se nanj odziva okolje. V teoretičnem delu smo nadaljevali in predstavili definicijo spolnega nadlegovanja, ki je kakršna koli oblika nezaželenega verbalnega in neverbalnega ali fizičnega ravnanja spolne narave z učinkom ali nameno...

  1. Studies on NaXe Clusters

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The chemical shift of 23Na in excimer NaXe was measured by using nuclear magnetic resonance (NMR) spectra, which is in good agreement with the theoretical value obtained by ab initio calculations. The bond length, dissociation energy, dipole of NaXe and Mulliken charges at Na and Xe in NaXe were calculated, respectively. The spectra of ultraviolet (UV) fluorescence and surface-enhanced Raman scattering of NaXe were also measured.

  2. Wpływ języka polskiego na leksykę medyczną w gwarze staroobrzędowców regionu suwalsko-augustowskiego

    Directory of Open Access Journals (Sweden)

    Magdalena Katarzyna Grupa

    2016-12-01

    Full Text Available The Influence of Polish Language on Medical Terminology in the Old Believers’ Dialect in Suwałki-Augustów Region The Old Believers in Poland are a bilingual community. They use two languages: Russian dialect and Polish language. Polish influence on the Old Believers’ dialect increased after two World Wars, when they became separated from their co-religionists in other countries and had more often contacts with Polish neighbours. Their language situation may be characterized as diglossia – they choose one of their languages depending on the domain of life and other social conditions. The medical terminology is a specific part of the Old Believers’ dialect. There are a lot of borrowings from Polish language caused by the need of protection of health and life in Poland, where the Old Believers met first of all with Polish health care system. The article is an attempt to characterize the influence of Polish language in the lexis describing medicine and health care.   Wpływ języka polskiego na leksykę medyczną w gwarze staroobrzędowców regionu suwalsko-augustowskiego Staroobrzędowcy w Polsce są społecznością dwujęzyczną. Posługują się rosyjską gwarą oraz językiem polskim. Częstsze kontakty z Polakami po I i II wojnie światowej oraz izolacja od współwyznawców w innych krajach poskutkowały modyfikacjami języka. Ich sytuację językową określa się jako dyglosję – zjawisko polegające na używaniu dwu (lub więcej języków naprzemiennie, zależnie od sytuacji komunikacyjnej. Terminologia medyczna jest specyficzną częścią systemu leksykalnego polskich starowierców. Cechuje ją znaczna liczba zapożyczeń z polszczyzny w stosunku do leksyki rosyjskiego języka ogólnego i rodzimej gwary rosyjskiej. Znajduje to uzasadnienie w konieczności przyswojenia sobie terminów związanych z lecznictwem w ich polskim brzmieniu, dzięki czemu możliwe jest korzystanie z opieki zdrowotnej w Polsce. W artykule zosta

  3. WPŁYW SENSORA Z WŁÓKIEN WĘGLOWYCH DO POMIARU ODKSZTAŁCEŃ NA NOŚNOŚĆ BELEK ŻELBETOWYCH

    Directory of Open Access Journals (Sweden)

    Rafał KRZYWOŃ

    2016-07-01

    Full Text Available Przyklejane do konstrukcji kompozyty zbrojone włóknem węglowym zdobywają coraz większą popularność w zastosowaniach budowlanych, jednakże, z uwagi na kruche właściwości ich użytkowanie jest obarczone znacznie większym ryzykiem niż w przypadku tradycyjnych stali. Diagnostyka wzmocnionych elementów tylko przez obserwację ich zarysowań czy ugięć może być niewystarczająca, potrzebne są dodatkowe systemy monitorujące. W referacie przedstawiono opracowaną przez autorów inteligentną tkaninę, w której wiązki włókien węglowych łączą rolę rozciąganego zbrojenia i miernika odkształceń. Zasada jej pracy jest inspirowana budową klasycznego tensometru elektrooporowego, którego włókna przewodzące prowadzone są wężykowo. Rolę przewodnika pełni wiązka włókien węglowych, która jest izolowana w matrycy z włókien szklanych lub akrylowych. Opisane w referacie wybrane wyniki badań laboratoryjnych są bardzo obiecujące zarówno w zakresie jakości pomiaru odkształceń, jak i efektywności wzmocnienia. Obecnie dopracowywane są: dokładność kontroli grubości wiązki włókien, która wpływa na całkowitą oporność, czy też wpływ wilgoci na zmiany oporności.

  4. Na via do Behemoth

    Directory of Open Access Journals (Sweden)

    Gérard Rabinovitch

    2008-06-01

    Full Text Available O momento nazista permanece um enigma impensado de que a cultura contemporânea continua cativa. O autor levanta a hipótese de que a persistência desse enigma e seus estragos duráveis se devem à insistência dos pensamentos político, sociológico e filosófico em construírem o nazismo à luz da metáfora hobbesiana do Leviatã. Propõe retomar a questão do nazismo sob a perspectiva do Behemoth, antônimo do Leviatã. Para tanto, sugere a necessidade de retornar a Freud e à psicanálise, balizas de um possível novo pensamento do político que escrutine a destrutividade nazista. Propõe ainda sondar as homologias entre nazismo, corjas e máfias, com base na figura da " heroicização da violência" que lhes seria comum. E avança um modelo " econômico" : a quimera, suscetível de capturar o caráter heterotópico e heterocrônico de sua construção criminosa.The paths of Behemoth. The Nazi moment remains as the thoughtless enigma of which contemporary culture is still captive. The author raises the hypothesis where the persistency of this enigma and its durable damages are due to the insistence of the political, social and philosophical thoughts in building the Nazism at the view of the Hobbesian metaphor of Leviathan. It is here proposed to resume the Nazism matter under Behemoth's perspective, antonym to Leviathan. For such, it is suggested a necessity to look back at Freud and the psychoanalysis, structured by a possible new political thought which scrutinizes the destructivity of the Nazism. It is also here proposed to gaze at the homologies between Nazism, mafias and gangs, with a base in the figure of " violence as a heroically act" that are their common ground. The author also advances an economical model: the chimera susceptible to capture the heterotopic and heterochronic character of its criminal construction.

  5. Results from NA61/SHINE

    Directory of Open Access Journals (Sweden)

    Unger M.

    2013-06-01

    Full Text Available In this paper we summarize recent results from NA61/SHINE relevant for heavy ion physics, neutrino oscillations and the interpretation of air showers induced by ultra-high energy cosmic rays.

  6. Risbjerg: Historisk stemmeskred med NA

    DEFF Research Database (Denmark)

    Thomsen, Søren Risbjerg

    2007-01-01

    ANALYSE: NA flytter 12,3 pct. af stemmerne i majs meningsmålinger - historisk mange vælgere på en måned, skriver professor Risbjerg. Udgivelsesdato: 3. juni 2007......ANALYSE: NA flytter 12,3 pct. af stemmerne i majs meningsmålinger - historisk mange vælgere på en måned, skriver professor Risbjerg. Udgivelsesdato: 3. juni 2007...

  7. Na+ recirculation and isosmotic transport.

    Science.gov (United States)

    Larsen, E H; Møbjerg, N

    2006-01-01

    The Na(+) recirculation theory for solute-coupled fluid absorption is an expansion of the local osmosis concept introduced by Curran and analyzed by Diamond & Bossert. Based on studies on small intestine the theory assumes that the observed recirculation of Na(+) serves regulation of the osmolarity of the absorbate. Mathematical modeling reproducing bioelectric and hydrosmotic properties of small intestine and proximal tubule, respectively, predicts a significant range of observations such as isosmotic transport, hyposmotic transport, solvent drag, anomalous solvent drag, the residual hydraulic permeability in proximal tubule of AQP1 (-/-) mice, and the inverse relationship between hydraulic permeability and the concentration difference needed to reverse transepithelial water flow. The model reproduces the volume responses of cells and lateral intercellular space (lis) following replacement of luminal NaCl by sucrose as well as the linear dependence of volume absorption on luminal NaCl concentration. Analysis of solvent drag on Na(+) in tight junctions provides explanation for the surprisingly high metabolic efficiency of Na(+) reabsorption. The model predicts and explains low metabolic efficiency in diluted external baths. Hyperosmolarity of lis is governed by the hydraulic permeability of the apical plasma membrane and tight junction with 6-7 mOsm in small intestine and < or = 1 mOsm in proximal tubule. Truly isosmotic transport demands a Na(+) recirculation of 50-70% in small intestine but might be barely measurable in proximal tubule. The model fails to reproduce a certain type of observations: The reduced volume absorption at transepithelial osmotic equilibrium in AQP1 knockout mice, and the stimulated water absorption by gallbladder in diluted external solutions. Thus, it indicates cellular regulation of apical Na(+) uptake, which is not included in the mathematical treatment.

  8. Pomiar wytrzymałości na zginanie jako metoda oceny jakości spoiwa na przykładzie mas ze szkłem wodnym

    Directory of Open Access Journals (Sweden)

    M. Stachowicz

    2012-12-01

    Full Text Available W pracy podjęto próbę określenia możliwości zastosowania parametru wytrzymałości na zginanie utwardzonych mas jako kryteriumoceny jakości użytego do ich sporządzenia spoiwa. W tym celu zaprezentowano wyniki badań wpływu wybranych czterech metodutwardzania spoiwa uwodnionego krzemianu sodu. Wybrane ekologiczne, nieorganiczne spoiwo stosowane jest do wytwarzania zarównoform, jak i rdzeni odlewniczych. Oceny skuteczności metod utwardzania spoiwa dokonano odnosząc otrzymane wartości wytrzymałościna zginanie do ilości użytego do sporządzenia masy formierskiej szkła wodnego. W badaniach zastosowano pięć gatunków uwodnionegokrzemianu sodu i wybrane cztery metody jego utwardzania. Stwierdzono, że możliwym jest wykorzystywanie opracowanej oceny jakości spoiw, w szczególności stosowanych do wykonywania rdzeni odlewniczych według zaproponowanego trzyklasowego podziału.

  9. Transpondo muros: Escritas da violência na República Democrática Alemã

    Directory of Open Access Journals (Sweden)

    Elcio Loureiro Cornelsen

    2009-06-01

    Full Text Available O objetivo do presente artigo é esboçar, a partir da interpretação das obras “Zeit-Zeugen”. Inhaftiert in Berlin-Hohenschönhausen (1996, organizada por Gabriele Camphausen, Folterzelle 36 Berlin-Pankow. Erlebnisbericht einer Stasihaft (1993, de Timo Zilli, Ein guter Kampf. Fakten, Daten, Erinnerungen 1945-1954 (1998 do político Ewald Ernst, Die Stasi war mein Eckermann: oder mein Leben mit der Wanze (1991, do escritor Erich Loest, e Geboren am 13. August. Der Sozialismus und ich (2004, do jornalista Jens Bisky, um breve estudo sobre as diversas formas e fases da violência enquanto instrumento de poder, praticada pelo Estado do SED na República Democrática Alemã nos 40 anos de sua existência, e discutir especialmente alguns aspectos teóricos sobre o conceito de “literatura de testemunho”. Os cinco relatos analisados, de caráter memorialista e autobiográfico, se pautam por um tom decididamente crítico frente aos desmandos num Estado totalitário. “Transpor muros” nos 20 anos após a Queda do Muro de Berlim, desse ponto de vista, implica um olhar memorialista de denúncia contra o esquecimento frente a um passado traumático.

  10. Dificuldades da aprendizagem na leitura

    Directory of Open Access Journals (Sweden)

    Solange Oliveira Nascimento

    2011-07-01

    Full Text Available Este presente artigo propôs verificar os fatores que influenciam no desenvolvimento da aprendizagem na leitura dos alunos da 4º ano no Ensino Fundamental na Escola Municipal Armando Dias no município de Sinop/MT, cujo tema é dificuldade da aprendizagem na leitura. O objetivo do trabalho foi investigar as relações interpessoais em sala de aula e de que forma a professora introduz a leitura nos conteúdos dados aos alunos. Como fundamentação teórica, recorremos a vários autores, entre eles: Enrique Cártula Fita, Elisabete da Assunção Jóse, Jésus Alonso Tapia, Maria Tereza Coelho e Ruth Caribe da Rocha Drouet. A metodologia usada consistiu na pesquisa qualitativa, no estudo de caso e questionário com perguntas abertas e fechadas aplicadas à professora e três alunos que estão com dificuldades na leitura. Através dos relatos dos sujeitos realizamos um estudo analítico confrontando os dados da pesquisa com os autores principais que fundamentam a mesma. O presente trabalho pretende contribuir e mostrar ao professor em sala de aula a importância de incentivar os alunos a aprenderem a ler com prazer motivando-os a despertar o interesse e gosto pela leitura. Os resultados da investigação revelam que a professora pesquisada está ciente de seu papel e procura meios para enfrentar os problemas existentes em sala de aula, em especial às dificuldades da aprendizagem na leitura e os alunos percebem a importância da leitura e tem vontade em avançar nesse aprendizado.Palavras-chave: educação; dificuldades na aprendizagem. professor; aluno; sala de aula.

  11. Na Deposition on MnO(100)

    Science.gov (United States)

    Feng, Xu; Cox, David F.

    2016-03-01

    Na deposition on the MnO(100) surface was investigated by temperature programmed desorption (TPD), X-ray photoelectron spectroscopy (XPS) and low energy electron diffraction (LEED). Na TPD and XPS results indicate that adsorbed Na interacts strongly with the MnO substrate to form an irreversibly-adsorbed, oxidic Na compound on the surface for coverages up to 1 monolayer (ML). This strongly-bound Na diffuses into the MnO subsurface and bulk at elevated temperatures above 500 K. For Na coverages above 1 ML, metallic Na is present and desorbs from the surface below 500 K. The deposition of Na on MnO(100) follows a Stranski-Krastanov (SK) growth mode, with the formation of metallic Na islands following completion of the first Na monolayer. After Na deposition, the surface exhibits a diffuse (1 × 1) LEED pattern, suggesting the formation of disordered Na overlayers. After heating to 1000 K, the surface presents a (2 × 2) LEED pattern indicating that a surface reconstruction is induced by the diffusion of Na into the near surface region. CO2 can be used as a probe molecule in TPD to distinguish between metallic Na islands and oxidic Na in the first ML, and to indicate when Na that is still observable by XPS goes subsurface.

  12. Jezična analiza lista Naš glas

    OpenAIRE

    2015-01-01

    U radu se analizira jezik Našega glasa (list „Riviere“ – radne organizacije za ugostiteljstvo, turizam, trgovinu i proizvodnju) koji je izlazio u Poreču od 1969. do 1982. godine. Nakon kratkoga osvrta na strukturu, sadržaj i ulogu toga lista te njegov značaj za stanovništvo lokalne zajednice, slijedi prikaz jezičnih zbivanja u vrijeme njegova izlaženja. U žarištu su istraživanja pravopisne, morfološke, sintaktičke, tvorbene, leksičke i stilske karakteristike lista. Rezultati istraživanja poka...

  13. All new for NA62

    CERN Multimedia

    Antonella Del Rosso

    2012-01-01

    This week sees the start of the first run of the new NA62 experiment. This will be a unique opportunity for the collaboration to test its new beam, new detectors and new data acquisition system before the physics run in 2014. Speaking to the Bulletin, the NA62 technical coordinator Ferdinand Hahn shares the many challenges that the various teams faced to be on time for beam. Ready, steady, start!   A Large Angle Veto detector (white) in place in the NA62 decay volume (blue). With components from almost all the detectors in place downstream of the decay point of the mother particles – the kaons – and of the KTAG detector that tags the kaons before they decay, NA62 is ready for its first technical run. This unique run will test all the equipment as well as the trigger and the data acquisition systems. “This year, we will have about five weeks of beam from the SPS before the long shutdown of all the CERN machines,” says Ferdinand Hahn, NA62 Technical Co-...

  14. Corpo e sexualidade na gravidez

    Directory of Open Access Journals (Sweden)

    Natalúcia Matos Araújo

    2012-06-01

    Full Text Available Estudo etnográfico que teve como objetivo compreender como as gestantes vivenciam os processos fisiológicos do seu corpo durante a gestação e a sua repercussão na sexualidade. A pesquisa envolveu sete mulheres residentes em bairro popular de São Paulo. Na coleta de dados, utilizou-se observação participante e entrevista com questões norteadoras. Os dados foram apresentados na forma de narrativa e posteriormente organizados nas categorias: Percebendo as transformações corporais; Convivendo com as mudanças no corpo; Sentimentos e sensações na vida sexual durante a gestação e imaginando o corpo e a sexualidade após a gestação. As mulheres referiram-se às transformações do corpo como desconfortos e expressaram a preocupação de que fossem definitivas. Expressaram o desejo de que, após o parto, o corpo volte a ser como era e que volte a sentir desejo sexual. O reconhecimento destes fatos constitui-se numa ferramenta primordial na adequação das práticas profissionais.

  15. Kawachin na ri kitzij-kipixab' Qanan Qatat--Florezcan las palabras de los hombres de maiz (The Blossoming of Our Ancestors' Words). [CD-ROM].

    Science.gov (United States)

    Academy for Educational Development, Washington, DC.

    This CD-ROM is part of an interactive and dynamic multimedia package of information and games for learning K'iche' and Ixil. This CD-ROM contains selected radio programs for preschool students, scripted from the four storybooks created by Project "Enlace Quiche." It includes stories in K'iche', Ixil, and Spanish. (VWL)

  16. Kawachin na ri kitzij-kipixab' Qanan Qatat--Florezcan las palabras de los hombres de maiz (The Blossoming of Our Ancestors' Words). [CD-ROM].

    Science.gov (United States)

    Academy for Educational Development, Washington, DC.

    This CD-ROM is part of an interactive and dynamic multimedia package of information and games for learning K'iche' and Ixil. This CD-ROM contains selected radio programs for preschool students, scripted from the four storybooks created by Project "Enlace Quiche." It includes stories in K'iche', Ixil, and Spanish. (VWL)

  17. gigapanorama of NA 62 cavern

    CERN Multimedia

    Brice, Maximilien

    2015-01-01

    The image shows the new rare Kaon decay experiment at CERN, called NA62. The NA62 experiment is 270 metres long and includes a 120-metre-long vacuum tank, shown here, housing several of the particle detectors. (Note: the experiment axis is a straight line, the curving of the tank is an optical effect of the photo.) Kaons are particles that decay into lighter elementary particles. The kaon decay processes are mostly well known, except for some very rare decay modes. For example, NA62 is investigating a rare decay predicted by the Standard Model in which a kaon decays into one pion and two neutrinos. This process occurs only once every 10 billion decays. The understanding of such ultra-rare decays are of great importance because they test the Standard Model in energy ranges not accessible by direct measurements. They are therefore complementary to the measurements at the LHC. ultra high definition on demand (photolab@cern.ch).

  18. Alcool e drogas na esquizofrenia

    OpenAIRE

    Marilia Montoya Boscolo

    2000-01-01

    Resumo: O objetivo deste trabalho é estudar o fenômeno do uso de álcool e drogas ilícitas (maconha e cocaína) na esquizoftenia. Trata-se de estudo comparativo, casocontrole, de dois grupos de esquizoftênicos pareados para sexo e idade, que preencheram os critérios diagnósticos do DSMIV para esquizoftenia. O grupo caso é definido por esquizofrênicos que têm história de ter feito uso de álcool, pelo menos no último mês e/ ou história de ter feito uso de drogas (maconha e cocaína), pelo menos al...

  19. Criatividade na Gestalt–terapia

    Directory of Open Access Journals (Sweden)

    Patrícia Albuquerque Lima

    2009-04-01

    Full Text Available Como se conceitua criatividade na teoria da Gestalt–terapia? Qual o papel e a função da criatividade nesta abordagem? O que se considera como um comportamento criativo no senso comum é tão diferente do que compreendemos, na abordagem gestáltica, como criatividade? Estas são algumas das perguntas sobre as quais buscaremos transcorrer ao longo deste artigo. Partimos de simples perguntas, pois talvez um bom recurso para se “tratar” da criatividade seja a curiosidade. Para isto, iremos apresentar a contribuição de alguns autores que discorreram sobre o tema da criatividade em suas obras, iniciando por Kurt Goldstein e sua Teoria Organísmica, que consideramos o principal substrato teórico para se pensar a criatividade na Gestalt–terapia.

  20. The NA48 trigger supervisor

    CERN Document Server

    Arcidiacono, R; Berotto, F; Bertolino, F; Govi, G; Menichetti, E; Sozzi, M

    2000-01-01

    The NA48 experiment aims to measure direct CP violation in the K/sub L//sup 0/ decays system with an accuracy of 2*10/sup -4/. High performances are required to the trigger and acquisition systems. This paper describes the NA48 Trigger Supervisor, a 40 MHz pipelined hardware system which correlates and processes trigger informations from local trigger sources, searching for interesting patterns. The trigger packet include a timestamp information used by the readout systems to retrieve detector data. The design architecture and functionality during 98 data taking are described. (5 refs).

  1. Criatividade na Gestalt–terapia

    OpenAIRE

    Patrícia Albuquerque Lima

    2009-01-01

    Como se conceitua criatividade na teoria da Gestalt–terapia? Qual o papel e a função da criatividade nesta abordagem? O que se considera como um comportamento criativo no senso comum é tão diferente do que compreendemos, na abordagem gestáltica, como criatividade? Estas são algumas das perguntas sobre as quais buscaremos transcorrer ao longo deste artigo. Partimos de simples perguntas, pois talvez um bom recurso para se “tratar” da criatividade seja a curiosidade. Para isto, iremos apresentar...

  2. Výzkumy vlivu některých typů technologií na vědomosti a dovednosti žáků v matematice

    Directory of Open Access Journals (Sweden)

    Jarmila Robová

    2013-10-01

    Full Text Available Článek je věnován přehledu a analýze našich i zahraničních výzkumů, které se zabývají vlivem technologií na vědomosti a dovednosti žáků v matematice v období od devadesátých let dvacátého století až po současnost. Postupně jsou prezentovány a rozebírány metody i výsledky experimentů zaměřených na používání některých typů technologií, a to grafických kalkulátorů, programů dynamické geometrie a webových výukových zdrojů. Pozornost je věnována zejména relevantním výzkumům, které zkoumaly začlenění uvedených technologií do vyučování matematice na úrovni střední školy. Závěrem jsou shrnuty hlavní přínosy a rizika integrace těchto technologií a uvedeny současné trendy jejich integrace.

  3. Determination of the (Na+) Sternheimer antishielding factor by 23Na NMR spectroscopy on sodium oxide chloride, Na3OCl.

    Science.gov (United States)

    Klösters, G; Jansen, M

    2000-07-01

    The (Na+) Sternheimer antishielding factor gammainifinity (Na+) was determined by 23Na NMR spectroscopy on sodium oxide-chloride, Na3OCl. The quadrupolar coupling constant of the sodium ion in Na3OCI was determined to QCC = 11.34 MHz, which presents the largest coupling constant of a sodium nucleus observed so far. Applying a simple point charge model, the largest principal value of the electric field gradient at the sodium site was calculated to V(zz) = -6.76762 x 10(20) V/m2. From these values we calculated the (Na+) Sternheimer antishielding factor to gammainifinity (Na+)= -5.36. In sodium oxide, Na2O, we observed an isotropic chemical shift of deltaCS = 55.1 ppm, referenced to 1 M aqueous NaCI (delta = 0 ppm).

  4. NA60 frees the quarks

    CERN Multimedia

    2003-01-01

    Fitted with new state-of-the-art silicon detectors, NA60 is prepared to study the phase transition from confined hadronic matter to a deconfined (free) quark-gluon plasma, a state of matter which probably existed an instant after the Big Bang.

  5. NA62: Hidden Sector Physics

    CERN Document Server

    Cesarotti, Carissa Joyce

    2016-01-01

    Modern experimental physics is often probing for new physics by either finding deviations from predictions on extremely precise measurements, or by looking for a new signal that cannot be explained with existing models. The NA62 experiment at CERN does the former by measuring the ultra-rare decay $K^+ \\rightarrow \\pi^+ \

  6. Li Na Aces French Open

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Chinese tennis player becomes the first Asian to win a Grand Slam singles title Chinese tennis player Li Na beat defending champion Francesca Schiavone from Italy,6-4,7-6,on the clay court at Roland Garros,winning the 2011 French Open Tennis Tournament on June 4.She made history by becoming the first Chinese to win a grand slam singles title.

  7. Astrocytes generate Na+-mediated metabolic waves.

    Science.gov (United States)

    Bernardinelli, Yann; Magistretti, Pierre J; Chatton, Jean-Yves

    2004-10-12

    Glutamate-evoked Na+ increase in astrocytes has been identified as a signal coupling synaptic activity to glucose consumption. Astrocytes participate in multicellular signaling by transmitting intercellular Ca2+ waves. Here we show that intercellular Na+ waves are also evoked by activation of single cultured cortical mouse astrocytes in parallel with Ca2+ waves; however, there are spatial and temporal differences. Indeed, maneuvers that inhibit Ca2+ waves also inhibit Na+ waves; however, inhibition of the Na+/glutamate cotransporters or enzymatic degradation of extracellular glutamate selectively inhibit the Na+ wave. Thus, glutamate released by a Ca2+ wave-dependent mechanism is taken up by the Na+/glutamate cotransporters, resulting in a regenerative propagation of cytosolic Na+ increases. The Na+ wave gives rise to a spatially correlated increase in glucose uptake, which is prevented by glutamate transporter inhibition. Therefore, astrocytes appear to function as a network for concerted neurometabolic coupling through the generation of intercellular Na+ and metabolic waves.

  8. Europlanet NA2 Science Networking

    Science.gov (United States)

    Harri, Ari-Matti; Szego, Karoly; Genzer, Maria; Schmidt, Walter; Krupp, Norbert; Lammer, Helmut; Kallio, Esa; Haukka, Harri

    2013-04-01

    Europlanet RI / NA2 Science Networking [1] focused on determining the major goals of current and future European planetary science, relating them to the Research Infrastructure that the Europlanet RI project [2] developed, and placing them in a more global context. NA2 also enhanced the ability of European planetary scientists to participate on the global scene with their own agenda-setting projects and ideas. The Networking Activity NA2 included five working groups, aimed at identifying key science issues and producing reference books on major science themes that will bridge the gap between the results of present and past missions and the scientific preparation of the future ones. Within the Europlanet RI project (2009-2012) the NA2 and NA2-WGs organized thematic workshops, an expert exchange program and training groups to improve the scientific impact of this Infrastructure. The principal tasks addressed by NA2 were: • Science activities in support to the optimal use of data from past and present space missions, involving the broad planetary science community beyond the "space club" • Science activities in support to the preparation of future planetary missions: Earth-based preparatory observations, laboratory studies, R&D on advanced instrumentation and exploration technologies for the future, theory and modeling etc. • Develop scientific activities, joint publications, dedicated meetings, tools and services, education activities, engaging the public and industries • Update science themes and addressing the two main scientific objectives • Prepare and support workshops of the International Space Science Institute (ISSI) in Bern and • Support Trans National Activities (TNAs), Joined Research Activities (JRAs) and the Integrated and Distributed Information Service (IDIS) of the Europlanet project These tasks were achieved by WG workshops organized by the NA2 working groups, by ISSI workshops and by an Expert Exchange Program. There were 17 official WG

  9. Verdade na Cena, Verdade na Vida: Boal e Stanislavski

    Directory of Open Access Journals (Sweden)

    Antonia

    2015-04-01

    Full Text Available À luz do conceito de verdade cênica, o presente artigo discute a influência do método Stanislavski nos primeiros experimentos no seio do Teatro Arena de São Paulo e também aponta rastros do mestre russo nos princípios da Poética do Oprimido de Augusto Boal. O objetivo primordial consiste em incentivar a construção de espetáculos-fórum, partindo de um trabalho com rigor físico e detalhamento psicológico stanislavskianos. Trabalho este, que pode ser desenvolvido na lógica interna do processo, na fase que precede a todo produto de criação, antes da intervenção do espectador e no âmbito de montagens profissionais de teatro-fórum, em projetos mais duradouros.

  10. Model improwizacji polifonicznej na tle popularnych metod improwizacji w muzyce rozrywkowej

    Directory of Open Access Journals (Sweden)

    Adam Fulara

    2012-12-01

    Full Text Available Artykuł składa się z dwóch części. Pierwsza z nich, bardziej ogólna, zawiera opis zjawisk związanych z improwizacją, zwłaszcza gitarową, z wyszczególnieniem problemów wykonawczych stojących przed improwizatorem. Dwa punkty widzenia zostały przedstawione: pierwszy, szczegółowy, opisuje po kolei elementy muzyki i ich znaczenie w procesie improwizacji, drugi bardziej ogólny mówi o zjawiskach, których nie da się opisać, ani analizować w prosty sposób, bądź są inne w przypadku każdego utworu. Należy do nich interakcja pomiędzy członkami zespołu, wyrażanie emocji poprzez muzykę i problematykę poszukiwań własnego głosu w sztuce. Ta część zawiera jeszcze opis trzech zupełnie różnych podejść do improwizacji na gitarze. Pierwsza to wykorzystanie centrum tonalnego (wzbogaconego napięciami dominantowymi, druga metoda polega na połączeniu harmonii utworu ze stosowanymi skalami (stosowana w muzyce fusion, trzecia polega na ścisłym wykorzystaniu dźwięków akordowych w improwizacji bez stosowania skal (charakterystyczna dla muzyki bebop. Druga część tekstu zawiera opis szczególnego rodzaju improwizacji polifonicznej z wykorzystaniem tappingu oburęcznego na gitarze. Model ten stoi w opozycji do trzech wcześniej przedstawionych sposobów rozumienia improwizacji gitarowej. System opiera się zarówno na metodach stosowanych w polifonii renesansu i baroku (m. in. melodia wiodąca Cantus Firmus, reguły kontrapunktu, jak i na założeniach jednogłosowej improwizacji bebopowej (wykorzystanie dźwięków wiodących, rozwiązania charakterystyczne dla czterodźwięków naturalnych. Opis ten nawiązuje do pierwszej części artykułu, grupując zagadnienia wokół poszczególnych elementów dzieła muzycznego. Ta część zawiera uwagi i spostrzeżenia zebrane w ciągu ośmiu lat poszukiwań własnej drogi muzycznej autora.

  11. Experimental Study on Steel Tank Model Using Shaking Table/ Badania Eksperymentalne Modelu Zbiornika Stalowego Na Stole Sejsmicznym

    Directory of Open Access Journals (Sweden)

    Burkacki Daniel

    2014-09-01

    Full Text Available Stalowe zbiorniki walcowe są bardzo popularnymi konstrukcjami używanymi do magazynowania produktów przemysłu chemicznego i naftowego. Ich bezpieczeństwo i niezawodność są kluczowe, ponieważ każde uszkodzenie może nieść za sobą bardzo poważne konsekwencje. Trzęsienia ziemi są najbardziej niebezpiecznymi, a zarazem najbardziej nieprzewidywalnymi obciążeniami dynamicznymi, które mogą oddziaływać na tego typu konstrukcje. Z drugiej strony ruchy podłoża związane ze wstrząsami górniczymi są uważane za mniej groźne z powodu osiągania niższych poziomów wartości przyspieszeń. Celem niniejszego artykułu jest przedstawienie wyników badań eksperymentalnych, które przeprowadzono na wykonanym w skali modelu rzeczywistego zbiornika zlokalizowanego na terenie Polski. Badania wykonano przy użyciu stołu sejsmicznego. Zakres badań obejmował testy harmoniczne właściwości dynamicznych oraz zachowanie się stalowego zbiornika walcowego podczas trzęsień ziemi oraz wstrząsów górniczych dla różnych poziomów wypełnienia cieczą. Wyniki badań pokazują, że produkt magazynowany może mieć znaczący wpływ na wartości parametrów dynamicznych oraz potwierdzają, iż poziom wypełnienia cieczą jest istotny w analizie konstrukcji. Porównanie odpowiedzi podczas trzęsień ziemi oraz wstrząsów górniczych wskazuje, iż to drugie wymuszenie może być w niektórych przypadkach bardziej niekorzystne.

  12. NA

    OpenAIRE

    1994-01-01

    Significant research in high performance analog-to-digital converters (ADCs) has been directed at retaining part of the high-speed flash ADC architecture, while reducing the total number of comparators in the circuit. The symmetrical number system (SNS) can be used to preprocess the analog input signal, reducing the number of comparators and thus reducing the chip area and power consumption of the ADC. This thesis examines a Very Large Scale Integrated (VLSI) design for a folding circuit for ...

  13. Kolesarske poti in prostorski razvoj na Ptuju

    OpenAIRE

    Novak, Matjaž

    2017-01-01

    Diplomska naloga Kolesarske poti in prostorski razvoj na Ptuju govori o kolesarjenju kot alternativi osebnemu avtomobilu za dnevne vožnje na delo, v šolo ali po opravkih. Predstavljene so prednosti in slabosti kolesarjenja ter primerjava med kolesom in osebnim avtomobilom, predvsem na kratkih razdaljah, kjer lahko kolo več kot uspešno nadomesti uporabo osebnega avtomobila. V diplomski nalogi je prav tako podrobno predstavljena kolesarska infrastruktura ter pravilno načrtovanje gradnje kolesar...

  14. Hrvatska milja na starim kartama

    Directory of Open Access Journals (Sweden)

    Marina Viličić

    2016-06-01

    Full Text Available Karta Stjepana Glavača iz 1673. godine vrijedan je i jedinstven primjerak hrvatske kartografske baštine. Na njoj je ucrtana hrvatska milja kojoj nema traga na kartama izrađenima prije Glavačeve karte. Više autora spominje vrijednost duljine hrvatske milje, ali nisu suglasni s iznosom njezine vrijednosti. Za potrebe ovoga rada, pored kopije Glavačeve karte pribavljene su i istražene kopije karata Janeza Vajkarda Valvasora iz 1689., Giacoma Cantellija da Vignole iz 1690., Antuna Belavića iz 1739. i karta Kraljevinâ Dalmacije, Hrvatske i Slavonije… iz 1746. na kojima je, pored ostalih milja, ucrtana i hrvatska milja. S pomoću tih ucrtanih milja izračunan je odnos između hrvatske i njemačke milje, zatim talijanske i hrvatske milje te potom francuske i hrvatske milje. Pored tih odnosa, dan je i pregled odnosa hrvatske milje i nekih drugih milja. Utvrđeno je da je duljina hrvatske milje jednaka 1/10 duljine ekvatorskog stupnja. Duljina hrvatske milje za Zemljin radijus R = 6371 km iznosi 11 120 m, odnosno približno 11 km.

  15. Corpo e velhice na contemporaneidade

    Directory of Open Access Journals (Sweden)

    Gabriela Felten da Maia

    2014-04-01

    Full Text Available A inegável atenção dada ao corpo na sociedade inspirou a construção deste trabalho, visto que os imperativos atuais são a beleza, a forma e o vigor. A velhice e a inexorabilidade da morte apresentam-se para este ideal como incômodos que devem ser afastados através de diversos hábitos "saudáveis" e “rejuvenescedores”, como a ginástica, os cosméticos, as vitaminas, procedimentos estético-cirúrgicos, entre outros. O modo de “ser velho”, então, passa a ser configurado não mais por estereótipos negativos, mas a partir de um ethos em que os idosos são apresentados como saudáveis, joviais, engajados, produtivos e autoconfiantes. São corpos que ultrapassam as marcas do tempo, atléticos, firmes e lisos. Logo, aqueles que não aderem a este ethos podem tornar-se desviantes, estranhos, velhos, ultrapassados e precisam, portanto, serem descartados ou escamoteados. Tendo em vista estas questões, o presente trabalho propõe-se a discutir sobre o tema velhice, corpo e sociedade, na tentativa de problematizar sobre os atuais modos de subjetivação e o envelhecimento na contemporaneidade.

  16. 叶芝《基督重临》中“大记忆”蕴含的《易经》辩证哲学%Analysis of“Spiritus mundi”in Yeats’s The Second Coming from perspective of I-Ching philosophy

    Institute of Scientific and Technical Information of China (English)

    陈恺熙

    2016-01-01

    叶芝的作品充满了多种宗教信义,“大记忆”就是其中之一。“大记忆”是叶芝在对东西方种种秘术亲身实践的基础上创立的与宗教息息相关的术语。叶芝的神秘宗教信义与《易经》的辩证哲学有着相通之处,二者均体现了人在社会变迁中思想精神的发展。从《易经》阴阳辩证哲学观点视角对叶芝《基督重临》( The Second Coming)的“大记忆”进行分析,探讨“大记忆”的成因及其蕴含的普世精神,并论证二者所蕴涵世界精神的互补与共存。%William Butler Yeats is one of the most famous poets in the twentieth century. His works containing a great deal of religious beliefs have been largely prevalent."Spiritus mundi" is one of his religious beliefs that had been founded based on his personal experiences of east and west occultism. I-Ching,one of Chinese classical philos-ophy,has similarity toYeats’religious beliefs. They both present dialectical relationship and development of objec-tive things. The paper tries to analyze Spiritus mundi in The Second Coming from the perspective of Occultism,ai-ming at probing the genesis and containing world spirit of"Spiritus mundi"as well as the similarity between Yeats’ religious beliefs and philosophy of I-Ching.

  17. Homocisteína Homocysteine

    Directory of Open Access Journals (Sweden)

    Lindalva Batista Neves

    2004-10-01

    Full Text Available A homocisteína, formada a partir da metionina hepática, é metabolizada nas vias de desmetilação e de transulfuração, sendo que seus valores plasmáticos e urinários refletem a síntese celular. Sua determinação, realizada em jejum e após sobrecarga de metionina, caracteriza as diferenças dessas vias metabólicas, principalmente quando de natureza genética. A hiper-homocisteinemia tem sido associada a maior risco de eventos aterotrombóticos, e a literatura sugere associação causal, independente de outros fatores de risco para doença arterial. Diminuição da homocisteína plasmática para valores normais é seguida de redução significante na incidência de doença aterotrombótica. A relação entre homocisteína e o fígado vem adquirindo importância nos dias atuais, uma vez que alterações das lipoproteínas e da depuração de metionina são comuns em pacientes com doença hepática crônica (hepatocelular e canalicular. O tratamento da hiper-homocisteinemia fundamenta-se na suplementação alimentar e medicamentosa de ácido fólico e vitaminas B6 e B12.Homocysteine, formed from hepatic methionine, is metabolized through the pathways of demethylation and transsulfuration. Its plasmatic and urinary values reflect the cell synthesis. Its determination after fasting and increased infusion of methionine shows the differences of these two metabolic pathways, mainly when it is related to genetic diseases. Hyperhomocysteinemia has been associated with a higher risk of vascular thrombotic events. Several authors suggest a causal relationship between these events independently of other risk factors for vascular diseases. Decrease in plasmatic homocysteine to normal levels is followed by a significant reduction on the incidence of vascular thrombotic events. The correlation between the liver and homocysteine is becoming more important because of the recent findings that alterations of lipoproteins and methionine clearance are

  18. Utjecaj načina zrenja na udjel vode u bezmasnoj tvari i na udjel masti u siru Trapistu

    OpenAIRE

    Kirin, Slavko

    2001-01-01

    U radu je istraživan utjecaj načina zrenja na udjel vode u bezmasnoj tvari i na udjel masti u siru Trapistu. U sadašnjoj proizvodnji (Lura, Tvornica Bjelovar), sir Trapist zrije na prirodan način s oblikovanjem kore, te vakuumski upakiran u termoskupljajuče plastične vrećice, čime se dobije sir bez kore. Utvrđeno je da spomenuti načini zrenja uvjetuju signifikantne razlike u udjelu vode u bezmasnoj tvari sira. On je 5,34 % viši kod sira Trapista u vrećici u odnosu na sir Trapist s korom. Udje...

  19. Das Ich und der Andere in der psychologischen Technikforschung

    DEFF Research Database (Denmark)

    Schraube, Ernst

    2012-01-01

    subjektiven Dimension menschlicher Lebenspraxis in der heutigen Psychologie beschrieben und gezeigt, warum die damit einhergehende Forschung die Bedeutung der Technik für die Lebensführung der Menschen nur unzureichend untersuchen kann. Daraufhin wird begründet, warum ein präzisiertes konzeptuelles...

  20. Ich glaube nicht an übersinnliche Kraft hinter Naturgesetzen

    CERN Document Server

    2005-01-01

    The European Organisation for Nuclear Research CERN in Geneva is the leader in research sector of the elementary particles. And a sud-tyrolean has an essential interest in it. Südtirol Online speaks with this physicist about Universe, the smallest components in nature, and about the question: "What is behind?"

  1. Wilhelm Reich, das Schreiben, meine Neurose und ich

    Directory of Open Access Journals (Sweden)

    Jan Decker

    2011-05-01

    Full Text Available Der Prosaiker, Dramatiker und Hörspielautor Jan Decker reflektiert in diesem Essay über Bedingungen und Widerstände des literarischen Schreibens. Dabei geht es weniger um poetologische Verfahren als vielmehr um ein Hinterfragen der Bedingungen und Dispositionen, die einen Menschen dazu verleiten, einen literarischen Text dort entstehen zu lassen, wo sich ein Selbstempfinden und die Welt berühren. Ein Bogen wird gespannt, der über die Erotik und Körperlichkeit des Schreibakts hinweg letztlich dazu führt, die »Ursprungsneurose« als das zu pflegende Enigma des Autors zu erkennen.

  2. Wissensmanagementsysteme in Schulen oder: wie bringe ich Ordnung ins Chaos?

    Directory of Open Access Journals (Sweden)

    Andreas Breiter

    2002-11-01

    Full Text Available Die zunehmende Ausstattung von Schulen mit digitalen Medien wird zu einer Herausforderung für die Organisationsentwicklung. Digitale Materialien der Lehrkräfte sowie Schülerarbeiten in digitalisierter Form wachsen tagtäglich an. Bisher fehlen geeignete organisatorische und technische Möglichkeiten zur Archivierung, Verteilung und Nutzung. In Unternehmen hat sich mit dem Begriff Wissensmanagement ein organsatorisches Konzept etabliert, das die Nutzung der Ressource Wissen optimieren will. Um diese Prozesse zu unterstützen, wurden und werden informations- und kommunikationstechnische Werkzeuge entwickelt, deren Übertragung auf den Schulbereich aufgrund dessen organisatorischer Komplexität aber scheitern muss. In diesem Beitrag werden diese Besonderheiten herausgestellt und die Erfahrungen mit der Entwicklung eines webbasierten Wissensmanagementsystems in Zusammenarbeit mit Schulen skizziert.

  3. Religie świata i ich stanowisko wobec eutanazji

    OpenAIRE

    Skura-Madziała, Anna

    2009-01-01

    The attitude towards death and dying reflects the society’s view on a human being as a subject. Due to the progress in medical science a growing interest has been observed in the problem of death, including the right to dignified dying. One of the issues connected with the phenomenon of dying is the problem of euthanasia seen as one’s right to decide on one’s own death in extreme cases. The question of the legality of euthanasia is becoming a subject of consideration more and more ...

  4. Guidelines from the International Conference on Harmonisation (ICH).

    Science.gov (United States)

    Branch, Sarah K

    2005-08-10

    This article describes the development of international guidance on registration of technical dossiers supporting applications to market medicinal products. Aspects of guidance of particular relevance to the use of NMR spectroscopy in drug development and control are discussed.

  5. Na+,K+-ATPase Na+ affinity in rat skeletal muscle fiber types

    DEFF Research Database (Denmark)

    Kristensen, Michael; Juel, Carsten

    2010-01-01

    Previous studies in expression systems have found different ion activation of the Na(+)/K(+)-ATPase isozymes, which suggest that different muscles have different ion affinities. The rate of ATP hydrolysis was used to quantify Na(+),K(+)-ATPase activity, and the Na(+) affinity of Na(+),K(+)-ATPase...

  6. A Perspectiva de estudos sobre os sujeitos na Arquivologia, na Biblioteconomia e na Museologia

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Ávila Araújo

    2015-01-01

    Full Text Available Arquivologia, Biblioteconomia e Museologia se constituíram, como disciplinas científicas, no final do século XIX, a partir da consolidação de um modelo custodial patrimonialista e, depois, com sua superação a partir de duas perspectivas: uma funcionalista e outra crítica. Posteriormente, uma outra tradição de pesquisa se desenvolveu: estudos realizados a partir do ponto de vista dos sujeitos (usuários, públicos que se relacionam com as instituições arquivo, biblioteca, museu, e que experimentam seus espaços e se apropriam dos conteúdos de seus acervos. O objetivo deste texto é analisar o desenvolvimento desta perspectiva na Arquivologia, na Biblioteconomia e na Museologia, bem como defender a importância de um diálogo maior entre os achados de pesquisa realizados neste âmbito em cada uma das três áreas analisadas.

  7. NaCl Potentiates Human Fibrocyte Differentiation

    OpenAIRE

    Nehemiah Cox; Darrell Pilling; Gomer, Richard H.

    2012-01-01

    Excessive NaCl intake is associated with a variety of fibrosing diseases such as renal and cardiac fibrosis. This association has been attributed to increased blood pressure as the result of high NaCl intake. However, studies in patients with high NaCl intake and fibrosis reveal a connection between NaCl intake and fibrosis that is independent of blood pressure. We find that increasing the extracellular concentration of NaCl to levels that may occur in human blood after high-salt intake can p...

  8. The hydrogen storage properties of Na decorated small boron cluster B6Na8

    Science.gov (United States)

    Tang, Chunmei; Wang, Zhiguo; Zhang, Xue; Wen, Ninghua

    2016-09-01

    The binding energy of the Na atoms to the hollow sites of the B6 cage is larger than the experimental cohesive energy of bulk Na, so the clustering of Na atoms can be avoided. The polarization interaction dominates the adsorption of H2 by the B6Na8 cluster. The Na-coated B6Na8sbnd B8sbnd B6Na8 complex with the dispersive Na atoms and four H2 molecules adsorbed per Na can serve as better building blocks of polymers than the (B6Na8)2 dimer. These findings suggest a new route to design cluster-assembled hydrogen storage materials based on sp2-terminated boron chains.

  9. Conversion and Distribution of Lead and Tin in NaOH-NaNO3 Fusion Process

    Science.gov (United States)

    Liu, Jingxin; Guo, Xueyi

    2017-04-01

    Oxidizing alkali fusion process has been studied to extract amphoteric metals. Transformation and distribution behaviors of typical amphoteric metals Pb and Sn in the NaOH-NaNO3 fusion process are systemically studied by theoretical analysis and experimental verification done in this work. Functions of NaOH and NaNO3 in the fusion process were also investigated. The results show the fused products, Na2PbO3 and Na2SnO3, are captured in the flux, and Na2PbO4 is speculated to reduce to Pb(II) in the following leaching process. By measuring solubility data of NaOH-Na2SnO3-PbO-H2O system, a strategy of crystallization is proposed to separate Sn with Pb in concentrated alkaline solution, and slice Na2Sn(OH)6 is obtained as a product.

  10. Silicene for Na-ion battery applications

    KAUST Repository

    Zhu, Jiajie

    2016-08-19

    Na-ion batteries are promising candidates to replace Li-ion batteries in large scale applications because of the advantages in natural abundance and cost of Na. Silicene has potential as the anode in Li-ion batteries but so far has not received attention with respect to Na-ion batteries. In this context, freestanding silicene, a graphene-silicene-graphene heterostructure, and a graphene-silicene superlattice are investigated for possible application in Na-ion batteries, using first-principles calculations. The calculated Na capacities of 954mAh/g for freestanding silicene and 730mAh/g for the graphenesilicene superlattice (10% biaxial tensile strain) are highly competitive and potentials of >0.3 V against the Na/Na potential exceed the corresponding value of graphite. In addition, the diffusion barriers are predicted to be <0.3 eV.

  11. Silicene for Na-ion battery applications

    Science.gov (United States)

    Zhu, Jiajie; Schwingenschlögl, Udo

    2016-09-01

    Na-ion batteries are promising candidates to replace Li-ion batteries in large scale applications because of the advantages in natural abundance and cost of Na. Silicene has potential as the anode in Li-ion batteries but so far has not received attention with respect to Na-ion batteries. In this context, freestanding silicene, a graphene-silicene-graphene heterostructure, and a graphene-silicene superlattice are investigated for possible application in Na-ion batteries, using first-principles calculations. The calculated Na capacities of 954 mAh/g for freestanding silicene and 730 mAh/g for the graphene-silicene superlattice (10% biaxial tensile strain) are highly competitive and potentials of \\gt 0.3 {{V}} against the Na{}+/Na potential exceed the corresponding value of graphite. In addition, the diffusion barriers are predicted to be \\lt 0.3 {eV}.

  12. Experimental Testing of Innovative Cold-Formed "GEB" Section / Badania Eksperymentalne Innowacyjnego Kształtownika Giętego Na Zimno Typu "Geb"

    Science.gov (United States)

    Łukowicz, Agnieszka; Urbańska-Galewska, Elżbieta; Gordziej-Zagórowska, Małgorzata

    2015-03-01

    One of the major advantages of light gauge steel structures made of cold-formed steel sections is their low weight so the production of typical single-storey steel structures of this kind of profiles is still rising. The well known profiles, e.o. Z-sections, C-sections and the so called hat-sections studied and described in the literature, are used mainly as purlins or truss components. A new profile GEB was patented for the use for primary load-bearing member in fabricated steel frames. According to the code [1] every novel cross section should be tested to assign the deformation shape and bearing capacity. The paper deals with the numerical and experimental research of bearing capacity of cold formed GEB profiles. The deformation shape and limit load was obtained from bending tests. The GEB cross section bearing capacity was also determined according to codes [1, 2]. Jedną z najważniejszych zalet lekkich konstrukcji metalowych, wytwarzanych z kształtowników giętych na zimno, jest ich mała masa, dlatego też, producenci coraz częściej wykorzystują możliwości profili giętych do wytwarzania typowych konstrukcji halowych w budownictwie systemowym. Proces gięcia na zimno, pozwala na formowanie różnego rodzaju przekrojów poprzecznych, które mogą być wykorzystywane jako elementy konstrukcji. Typowe kształty elementów. tzn. Z, C oraz tzw. przekroje kapeluszowe, które zostały przebadane i opisane w literaturze, wykorzystuje się głównie jako płatwie lub części składowe wiązarów kratowych. Nowo opatentowany przekrój typu GEB ma być wykorzystany jako element nośny konstrukcji ramowych. W związku z tym innowacyjny kształt oraz parametry geometryczne przekroju takiego kształtownika, związane z możliwością jego wyprodukowania oraz z warunkami nośności, stateczności oraz sztywności, muszą być optymalne. Według normy PN-EN 1993-1-3, każdy nowo uformowany przekrój powinien być przebadany pod kątem nośności elementu i formy

  13. Docência na universidade: professores inovadores na USP

    Directory of Open Access Journals (Sweden)

    Chamlian Helena Coharik

    2003-01-01

    Full Text Available O artigo trata de pesquisa realizada com um grupo de professores inovadores da Universidade de São Paulo tendo como objetivo procurar subsídios para a formação do professor universitário. Esses docentes foram entrevistados, solicitando que detalhassem melhor suas experiências inovadoras; explicassem as razões pelas quais haviam introduzido modificações em sua forma de trabalho; explicitassem as relações entre sua atividade de docência e de pesquisa, expressassem o papel que atribuíam ao ensino na universidade, bem como a forma pela qual sua trajetória acadêmica havia se cumprido até então. A diversidade de experiências relatadas e, ao mesmo tempo, a convergência de visões a respeito de suas funções de ensino e de pesquisa na universidade permitem-nos afirmar que, mais do que uma formação pedagógica específica, a sensibilização para as dificuldades do ensino e a valorização institucional dessa atividade consistiriam em grande avanço para a formação do professor.

  14. Pneumonia bacteriana adquirida na comunidade

    OpenAIRE

    Machado, Lais Del Prá Netto

    2015-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2015. A pneumonia pode ser causada por diversos microrganismos e classificada de forma abrangente, havendo poucos e frágeis estudos clínicos e epidemiológicos sobre pneumonias adquiridas na comunidade (PACs). Os patógenos mais frequentes nas PACs são Streptococcus pneumoniae e Haemophilus influenzae (em pneumonias típicas) e Mycoplasma pneumoni...

  15. New results from NA49

    CERN Document Server

    Afanasiev, S V; Bächler, J; Barna, D; Barnby, L S; Bartke, Jerzy; Barton, R A; Behler, M; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Blyth, C O; Boimska, B; Botje, M; Bracinik, J; Brady, F P; Bramm, R; Brun, R; Buncic, P; Carr, L; Cebra, D; Cerny, V; Cooper, G E; Cramer, J G; Csató, P; Dinkelaker, P; Eckardt, V; Eckhardt, F; Ferenc, D; Filip, P; Fischer, H G; Foder, Z; Foka, P Y; Freund, P; Friese, V; Gál, J; Ganz, R E; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Harris, J W; Hegyi, S; Höhne, C; Igo, G; Jacobs, P; Jones, P G; Kadija, K; Kolesnikov, V I; Kollegger, T; Kowalski, M; Kraus, I; Kreps, M; Lasiuk, B; Van Leeuwen, M; Lévai, Peter; Malakhov, A I; Margetis, S; Markert, C; Mayes, B W; Melkumov, G L; Mischke, A; Molnár, J; Nelson, J M; Odyniec, Grazyna Janina; Oldenburg, M; Pálla, G; Panagiotou, A D; Perl, K; Petridis, A; Pikna, M; Pinsky, L; Poskanzer, A M; Prindle, D J; Pühlhofer, F; Putschke, J; Reid, J G; Renfordt, A; Retyk, W; Ritter, H G; Röhrich, D; Roland, C; Roland, G; Rybicki, A; Sammer, T; Sann, H; Schäfer, E; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Snellings, R; Squier, G T A; Stock, Reinhard; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Toy, M; Trainor, T A; Trentalange, S; Ullrich, T S; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Voloshin, S A; Vranic, D; Wang, F; Weerasundara, D D; Wenig, S; Wetzler, A; Whitten, C; Xu, N; Yates, T A; Koo, I K; Zaranek, J; Zimányi, J

    2002-01-01

    Recent results of the NA49 experiment are presented. These cover first results on pion and kaon production, HBT, and charge fluctuations from Pb+Pb reactions at 40 AGeV and their comparison to 158 AGeV beam energy. Furthermore a study on baryon number transfer in p+p, centrality selected p+Pb and Pb+Pb collisions at 158 AGeV and new results on the system size dependence of kaon yields, including C+C and Si+Si data, are presented. Additionally, a first result on Lambda Lambda correlations is shown. (11 refs).

  16. The NA52 strangelet search

    CERN Document Server

    Weber, M; Baglin, C; Beck, H P; Borer, K; Bussière, A; Elsener, K; Gorodetzky, P; Guillaud, J P; Kabana, S; Klingenberg, R; Lehmann, G; Lindén, T; Lohmann, K D; Mommsen, R K; Moser, U; Pretzl, Klaus P; Schacher, J; Spiwoks, R; Tuominiemi, Jorma

    2001-01-01

    The NA52 experiment searches for long-lived charged strangelets in 158 a GeV c/sup -1/ Pb+Pb collisions at CERN SPS. The experiment is able to identify single particles coming from the collisions at p/sub t/=0. We collected 10/sup 13/ Pb+Pb interactions looking for negatively charged strangelets and 3*10/sup 11/ Pb+Pb interactions for positively charged ones. No evidence for the production of strangelets has been observed. We present here resulting experimental differential and total upper production limits. (8 refs).

  17. Types of Moulding and Methods of Eliminating Dry Rot in Historic Buildings: Example of Sobiescy Palace in Lublin (Based on Study by Mirosław Zaród)/ Zagrzybienia I Metody Odgrzybiania Obiektów Zabytkowych Na Przykładzie Pałacu Sobieskich W Lublinie (Na Podstawie Opracowania Dokonanego Przez M. Zaróda)

    Science.gov (United States)

    Wrana, Jan; Jarocka-Mikrut, Aleksandra

    2015-06-01

    By presenting Sobiescy Palace in Lublin as well as results of mycological research conducted in the said premises, the authors describe hazards and dangers arising from damp present in historic buildings for a long time. Results of mycological research quoted in this article indicate that differences in levels of damp depend on the cardinal direction a specific wall faces. The authors also pay attention to reasons for which the described premises suffer from damp and provide programmes of treatment and prevention. Furthermore, the article gives the reader a detailed insight into multiple opportunities for improving technical conditions of historic buildings and, at the same time, raising their functional standards. However, one must not forget to treat such premises with proper respect. W artykule przedstawiono zagrożenia tkwiące w długotrwałym narażeniu zabudowań historycznych na wilgoć na podstawie Pałacu Sobieskich w Lublinie oraz ekspertyzy mykologicznej. Zwrócono uwagę na różnice w wilgotności ścian oraz zależności wynikające z orientacji budowli względem stron świata. Opisano przyczyny występowania wilgoci w opisywanym założeniu jak również wskazano możliwości ich przeciwdziałaniu. Poprzez przedstawienie możliwych do zastosowania metod ochrony przed wspomnianymi czynnikami dowiedziono, iż możliwości poprawy stanu technicznego, a tym samym standardów funkcjonalnych obiektów zabytkowych jest wiele przy czym należy zachować szczególny szacunek do substancji zabytkowej

  18. Identidades Homossexuais na Territorialidade Tradicionalista

    Directory of Open Access Journals (Sweden)

    Edipo Djavan dos Reis Göergen

    2015-12-01

    Full Text Available Este artigo apresenta o debate teórico que sustenta a pesquisa de mestrado desenvolvida pelo autor. Tendo por base suas vivências em contextos de tradicionalismo gaúcho, o autor deste trabalho tem percebido a grande quantidade de homossexuais, ou indivíduos que se auto-denominam não-heterossexuais, integrando as atividades artísticas do Movimento Tradicionalista Gaúcho, ou a territorialidade tradicionalista. Interessado em investigar tal fenômeno, o autor tem desenvolvido o projeto de pesquisa “Os Espaços Paradoxais de Relações Homoeróticas na Territorialidade Tradicionalista”, sob orientação do prof. Dr. Benhur Pinós da Costa, no Programa de Pós-Graduação em Geografia (UFSM. Para que essa pesquisa seja realizada, levam-se em conta as relações de gênero e de sexualidade que estão envolvidas no tema. Dessa forma, por ainda se tratarem de temáticas tidas como insignificantes na sociedade em geral e marginalizadas no campo científico, para que o presente trabalho fosse empreendido, buscou-se amparo teórico nas geografias feministas e queer, segmentos contemporâneos da ciência geográfica.

  19. Identidades Homossexuais na Territorialidade Tradicionalista

    Directory of Open Access Journals (Sweden)

    Edipo Djavan dos Reis Göergen

    2015-12-01

    Full Text Available Este artigo apresenta o debate teórico que sustenta a pesquisa de mestrado desenvolvida pelo autor. Tendo por base suas vivências em contextos de tradicionalismo gaúcho, o autor deste trabalho tem percebido a grande quantidade de homossexuais, ou indivíduos que se auto-denominam não-heterossexuais, integrando as atividades artísticas do Movimento Tradicionalista Gaúcho, ou a territorialidade tradicionalista. Interessado em investigar tal fenômeno, o autor tem desenvolvido o projeto de pesquisa “Os Espaços Paradoxais de Relações Homoeróticas na Territorialidade Tradicionalista”, sob orientação do prof. Dr. Benhur Pinós da Costa, no Programa de Pós-Graduação em Geografia (UFSM. Para que essa pesquisa seja realizada, levam-se em conta as relações de gênero e de sexualidade que estão envolvidas no tema. Dessa forma, por ainda se tratarem de temáticas tidas como insignificantes na sociedade em geral e marginalizadas no campo científico, para que o presente trabalho fosse empreendido, buscou-se amparo teórico nas geografias feministas e queer, segmentos contemporâneos da ciência geográfica.

  20. NaCl potentiates human fibrocyte differentiation.

    Science.gov (United States)

    Cox, Nehemiah; Pilling, Darrell; Gomer, Richard H

    2012-01-01

    Excessive NaCl intake is associated with a variety of fibrosing diseases such as renal and cardiac fibrosis. This association has been attributed to increased blood pressure as the result of high NaCl intake. However, studies in patients with high NaCl intake and fibrosis reveal a connection between NaCl intake and fibrosis that is independent of blood pressure. We find that increasing the extracellular concentration of NaCl to levels that may occur in human blood after high-salt intake can potentiate, in serum-free culture conditions, the differentiation of freshly-isolated human monocytes into fibroblast-like cells called fibrocytes. NaCl affects the monocytes directly during their adhesion. Potassium chloride and sodium nitrate also potentiate fibrocyte differentiation. The plasma protein Serum Amyloid P (SAP) inhibits fibrocyte differentiation. High levels of extracellular NaCl change the SAP Hill coefficient from 1.7 to 0.8, and cause a four-fold increase in the concentration of SAP needed to inhibit fibrocyte differentiation by 95%. Together, our data suggest that NaCl potentiates fibrocyte differentiation. NaCl-increased fibrocyte differentiation may thus contribute to NaCl-increased renal and cardiac fibrosis.

  1. NaCl potentiates human fibrocyte differentiation.

    Directory of Open Access Journals (Sweden)

    Nehemiah Cox

    Full Text Available Excessive NaCl intake is associated with a variety of fibrosing diseases such as renal and cardiac fibrosis. This association has been attributed to increased blood pressure as the result of high NaCl intake. However, studies in patients with high NaCl intake and fibrosis reveal a connection between NaCl intake and fibrosis that is independent of blood pressure. We find that increasing the extracellular concentration of NaCl to levels that may occur in human blood after high-salt intake can potentiate, in serum-free culture conditions, the differentiation of freshly-isolated human monocytes into fibroblast-like cells called fibrocytes. NaCl affects the monocytes directly during their adhesion. Potassium chloride and sodium nitrate also potentiate fibrocyte differentiation. The plasma protein Serum Amyloid P (SAP inhibits fibrocyte differentiation. High levels of extracellular NaCl change the SAP Hill coefficient from 1.7 to 0.8, and cause a four-fold increase in the concentration of SAP needed to inhibit fibrocyte differentiation by 95%. Together, our data suggest that NaCl potentiates fibrocyte differentiation. NaCl-increased fibrocyte differentiation may thus contribute to NaCl-increased renal and cardiac fibrosis.

  2. Micotoxinas e Micotoxicoses na Avicultura

    Directory of Open Access Journals (Sweden)

    Santurio JM

    2000-01-01

    Full Text Available Esta revisão tem como objetivo principal mostrar, baseado em dezenas de pesquisas realizadas, os efeitos tóxicos das micotoxinas aflatoxinas, tricotecenos, zealenona e fumonisinas sobre o desempenho das aves. O descobrimento das propriedades hepatotóxicas e hepatocarcinogênicas de algumas linhagens de Aspergillus flavus e A. parasiticus em perus, na Inglaterra, no início da década de 1960, seguida pela elucidação da estrutura de seus metabólitos tóxicos, as aflatoxinas, deu novo enfoque e prioridade para a pesquisa sobre micotoxinas. Análises de aflatoxinas realizadas no Laboratório de Análises Micotoxicológicas (LAMIC da Universidade Fedaral de Santa Maria, entre os anos de 1986 e janeiro de 2000, em 15.600 amostras de alimentos destinados principalmente ao consumo animal, demonstram que no milho analisado, 41,9% das amostras estavam contaminadas por aflatoxinas. Em surtos de aflatoxicose no campo, uma das características mais marcantes é a má absorção que se manifesta como partículas de ração mal digeridas na excreta das aves. Também observa-se, em frangos e poedeiras que recebem AFL, extrema palidez das mucosas e pernas. Dietas deficientes em riboflavina ou colecalciferol (vit. D tornaram frangos sensíveis, nos índices de desenvolvimento corporal, a concentrações muito baixas de AFL. O efeito aflatoxina nos frangos é maior na fase inicial de crescimento, ou seja, quando as aves ingeriram aflatoxina nos primeiros 21 dias de vida, e quanto maior o nível de stress do lote, menor a quantidade de AFL para afetar negativamente seu desempenho, seja na produção de carne ou de ovos. As principais micotoxinas do grupo dos tricotecenos são: toxina T-2; deoxynivalenol (DON; diacetoxyscirpenol (DAS, todas produzidas através de diversas espécies de fungos do gênero Fusarium. Além dos tricotecenos, o fusarium também pode produzir zearalenona e fumonisinas. Dessas fusarium-toxinas, somente toxina T-2 gera patologias s

  3. Fotografia na Imprensa: conflitos na câmara escura

    Directory of Open Access Journals (Sweden)

    José Lúcio da Silva Menezes

    2014-07-01

    Full Text Available Este artigo recupera o teor ideológico do discurso que a Revista Veja elaborou sobre a classe trabalhadora que emergiu no cenário brasileiro, no final da década de 1970. O destaque dado aos trabalhadores como temática central resgatada, deve-se aos movimentos grevistas por eles encetados, após anos de ocultamento de sua resistência sob a repressão da ditadura civil-militar (1964-1985. Com a rebeldia operária, as matérias a respeito deste grupo, na Revista,foram se tornando mais constantes e visíveis, pois já não era mais possível, para a Revista Veja, ignorar a existência da classe operária que, com a força insurgente das greves, ocupava as ruas do Brasil.

  4. Miedź i ołów - zanieczyszczenia historyczne na Rynku Głównym w Krakowie

    Directory of Open Access Journals (Sweden)

    A. Garbacz-Klempka

    2012-12-01

    Full Text Available Zanieczyszczenie środowiska pierwiastkami metalicznymi związane jest z historyczną aktywnością człowieka, szczególnie tą o charakterzeprodukcyjnym, ale ma także genezę w handlu, przetwórstwie i wykorzystywaniu w codziennym życiu przedmiotów metalowych. W czasie badań archeologicznych, prowadzonych w latach 2005 - 2010 w obrębie Rynku Głównego w Krakowie, pozyskano liczne zabytki metalowe, świadczące o obecności surowców metali, głównie miedzi i ołowiu. Równocześnie zarejestrowano szereg zjawisk, potwierdzających obecność w gruncie obszarów o ponadnormatywnej koncentracji pierwiastków metalicznych. Najwyższe kumulacje miedzi i ołowiu obecne są w warstwach gruntu w rejonach związanych z funkcjonowaniem w średniowieczu urzędu Wielkiej Wagi. Zastosowano zarówno metody makro- i mikroskopowych obserwacji artefaktów, badania ich składu chemicznego metodami spektroskopii fluorescencji rentgenowskiej (XRF i fluorescencyjnej analizy rentgenowskiej w mikroobszarach (SEM EDS, jak i oznaczanie zawartości metali wyekstrahowanych z próbek gruntów za pomocą absorpcyjnej spektroskopii atomowej (AAS. Efekty przeprowadzonych badań z zakresu metaloznawstwa i geochemii przyniosły potwierdzenie faktu historycznej obróbki metali na Rynku Głównym w Krakowie, która stanowi główną przyczynę tak znacznego skażenia wielu komponentów środowiska ówczesnego miasta.

  5. Relative contributions of Na+/H+ exchange and Na+/HCO3- cotransport to ischemic Na-i(+) overload in isolated rat hearts

    NARCIS (Netherlands)

    Ten Hove, M; Nederhoff, MGJ; Van Echteld, CJA

    2005-01-01

    The Na+/H+ exchanger (NHE) and/or the Na+/HCO3- cotransporter (NBC) were blocked during ischemia in isolated rat hearts. Intracellular Na+ concentration ([Na+](i)), intracellular pH (pH(i)), and energy-related phosphates were measured by using simultaneous Na-23 and P-31 NMR spectroscopy. Hearts wer

  6. SISTEMI IPTV NA IP MULTIMEDIJSKEM PODSISTEMU

    OpenAIRE

    2013-01-01

    Diplomsko delo obravnava arhitekture sistemov IPTV na IP multimedijskem podsistemu ter pripadajoče storitve in funkcije IPTV na IP multimedijskem podsistemu. Predstavljene arhitekture prinašajo veliko novih funkcionalnosti, ki so podrobneje predstavljene po posameznih enotah. V nalogi je tudi podrobneje opisana arhitektura IP multimedijskega podsistema z ravninami in protokoli. Naloga se zaključuje s storitvami na takšnih arhitekturah.

  7. PREZENTACIJA RAZVALIN GRADU NA PIRAMIDI V MARIBORU

    OpenAIRE

    Šegula Seršen, Pina

    2014-01-01

    Diplomsko delo podaja predlog za ohranitev ostalin razvalin gradu na Piramidi v Mariboru. V njem načrtujemo ureditev arheološkega območja Piramida ter problematiko prezentiranja izkopanin v povezavi z umestitvijo novih kulturnih in izobraževalnih funkcij. Diplomsko delo je sestavljeno iz analitičnega in projektnega dela. V prvem delu so raziskani arhitekturni, zgodovinski in kulturnovarstveni aspekti, na podlagi katerih je razvit idejni projekt, opisan v drugem delu naloge.

  8. Dzieło sztuki na granicy przeszłości i przyszłości. Historia i patriotyzm w sztuce nieprofesjonalnej

    Directory of Open Access Journals (Sweden)

    Aleksandra Weronika Jarysz

    2016-01-01

    Full Text Available A work of art – a link between the present and the past. History and patriotism in non-professional art In her article, the author discusses art of non-professional artists who shape the national identity in an original way. In the former professional art, the works which illustrated and uplifted history were very popular. This phenomenon is still present among folk, naive, intuitive artists, generally speaking – non-professionals. The work of their hands and imagination is a tool serving the purpose of national values and ideas, and is sometimes the basis for broader considerations on the human condition. They balance between historical facts and ahistorical generalities. The martyrdom of the Polish nation with emphasis on the events of WWII has been inspiring artists, stimulating their imagination and artistic creation. Therefore numerous ‘monuments of patriotic art’ can be found in the wood sculpture, ceramics, painting, and glass painting works from the art collection of the Toruń Maria Znamierowska-Prüfferowa Ethnographic Museum.   Dzieło sztuki na granicy przeszłości i przyszłości. Historia i patriotyzm w sztuce nieprofesjonalnej W swoim artykule autorka prezentuje sztukę twórców nieprofesjonalnych, którzy w sposób oryginalny kształtują tożsamość narodową. W dawnej sztuce profesjonalnej dzieła, które ilustrowały i uwznioślały historię były bardzo popularne. To zjawisko jest nadal aktualne wśród twórców ludowych, naiwnych, intuicyjnych, ogólnie nazywając – nieprofesjonalnych. Dzieło ich rąk i wyobraźni jest narzędziem w służbie wartości i idei narodowych, a niekiedy stanowi podstawę do szerszych rozważań nad kondycją człowieka. Balansują oni między konkretem historycznym a ahistoryczną ogólnością. Martyrologia narodu polskiego z naciskiem na wydarzenia II wojny światowej inspirowała i inspiruje twórców, pobudza ich wyobraźnię i zmusza do twórczej kreacji. Stąd też zar

  9. O consumo na vida digital

    Directory of Open Access Journals (Sweden)

    Iuri Yudi Furukita Baptista

    2016-02-01

    Full Text Available O modelo de consumo não possui as mesmas características sempre: suas relações, motivações, formatos, espaços, interesses e atividades são construções sociais que se modificam atreladas ao cenário econômico, político e tecnológico. O presente trabalho repassa o surgimento da sociedade do consumidor para então conjecturar sobre as propriedades distintivas do consumo na vida digital. O que se defende ao final é que o consumidor já não se restringe ao papel de consumir.

  10. Fabrication of implanted $^{22}$Na targets

    CERN Multimedia

    2002-01-01

    A knowledge of the $^{22}$Na(p,$\\gamma$)$^{23}$ Mg reaction rate is of significant astrophysical interest. In order to complete previous studies of this reaction, radioactive $^{22}$Na targets of high purity are required. We ask for support to fabricate these targets via the implantation technique at ISOLDE GPS (off—line mode) using $^{22}$Na nuclides in an Al matrix produced in Nov. 1990 at the PSI (Zürich). The $^{22}$Na nuclides are released and ionized in a surface ionisation source, mass-analyzed at ISOLDE GPS, and implanted in a Ni-Ta backing and a C—foil in a special implantation setup.

  11. NA-NET numerical analysis net

    Energy Technology Data Exchange (ETDEWEB)

    Dongarra, J. (Tennessee Univ., Knoxville, TN (United States). Dept. of Computer Science Oak Ridge National Lab., TN (United States)); Rosener, B. (Tennessee Univ., Knoxville, TN (United States). Dept. of Computer Science)

    1991-12-01

    This report describes a facility called NA-NET created to allow numerical analysts (na) an easy method of communicating with one another. The main advantage of the NA-NET is uniformity of addressing. All mail is addressed to the Internet host na-net.ornl.gov'' at Oak Ridge National Laboratory. Hence, members of the NA-NET do not need to remember complicated addresses or even where a member is currently located. As long as moving members change their e-mail address in the NA-NET everything works smoothly. The NA-NET system is currently located at Oak Ridge National Laboratory. It is running on the same machine that serves netlib. Netlib is a separate facility that distributes mathematical software via electronic mail. For more information on netlib consult, or send the one-line message send index'' to netlib{at}ornl.gov. The following report describes the current NA-NET system from both a user's perspective and from an implementation perspective. Currently, there are over 2100 members in the NA-NET. An average of 110 mail messages pass through this facility daily.

  12. NA-NET numerical analysis net

    Energy Technology Data Exchange (ETDEWEB)

    Dongarra, J. [Tennessee Univ., Knoxville, TN (United States). Dept. of Computer Science]|[Oak Ridge National Lab., TN (United States); Rosener, B. [Tennessee Univ., Knoxville, TN (United States). Dept. of Computer Science

    1991-12-01

    This report describes a facility called NA-NET created to allow numerical analysts (na) an easy method of communicating with one another. The main advantage of the NA-NET is uniformity of addressing. All mail is addressed to the Internet host ``na-net.ornl.gov`` at Oak Ridge National Laboratory. Hence, members of the NA-NET do not need to remember complicated addresses or even where a member is currently located. As long as moving members change their e-mail address in the NA-NET everything works smoothly. The NA-NET system is currently located at Oak Ridge National Laboratory. It is running on the same machine that serves netlib. Netlib is a separate facility that distributes mathematical software via electronic mail. For more information on netlib consult, or send the one-line message ``send index`` to netlib{at}ornl.gov. The following report describes the current NA-NET system from both a user`s perspective and from an implementation perspective. Currently, there are over 2100 members in the NA-NET. An average of 110 mail messages pass through this facility daily.

  13. IZGRADNJA MIKRO HIDROELEKTRARNE NA SKRBINSKEM POTOKU

    OpenAIRE

    Brezočnik, Simon

    2012-01-01

    Namen diplomske naloge je izgradnja mikro hidroelektrarne na Skrbinskem potoku. Predstavljene so splošne komponente potrebne za proizvajanje električne energije na manjšem vodotoku ˝Skrbinski˝ potok z možnostjo agregata do moči 36 kVA. Tema diplomske naloge je zanimiva, saj je nekoč visokogorska kmetija že imela manjšo postrojenje za samooskrbo domačije z električno energijo v mlinu na potoku Žavc in na potoku Radoljna, kjer je proizvajala električno energijo za potrebe žage torej za razrez ...

  14. A Biotecnologia na esfera pública

    OpenAIRE

    2007-01-01

    Este trabalho foca o envolvimento de cidadãos ligados à agricultura, à I&D agronómica e ao meio rural em assuntos de inovação na agricultura,tomando como caso de estudo ‘a biotecnologia na agricultura’ designada por agrobiotecnologia ou biotecnologia verde, na qual se incluem os organismos geneticamente modificados (‘OGM’) ou transgénicos. O seu uso na agricultura tem gerado desacordo entre os seus adeptos e os seus opositores, incluindo-se nestes dois grupos diversos actores. Pelo facto d...

  15. STRES NA DELOVNEM MESTU X BANKE

    OpenAIRE

    Trtnik, Matjaž

    2010-01-01

    POVZETEK Namen tega diplomskega dela je predstaviti dejstva o prisotnosti stresa na delovnem mestu v X banki, ki sem jih pridobil s pomočjo raziskave v konkretni organizaciji. Cilj dela je zajeti različna poglavja in področja izbrane teme, jih preučiti in oceniti obstoječe stanje v podjetju, ter na podlagi zbranih podatkov podati predloge za izboljšave. Diplomsko delo sestavlja osem poglavij, kot celoto pa bi ga lahko razdelil na tri dele: V prvem, teoretičnem delu, bom za boljše r...

  16. NaHCO3 and NaC1 tolerance in chronic renal failure.

    Science.gov (United States)

    Husted, F C; Nolph, K D; Maher, J F

    1975-08-01

    In patients with chronic renal failure, NaHCO3 therapy may correct or prevent acidemia. It has been proposed that the NaHCO3 required will not result in clinically significant Na retention comparable to that from similar increases in NaC1 intake. In each of ten patients with chronic renal failure, creatinine clearance (Ccr) range 2.5-16.8 ml/min, on an estimated 10-meq Na and C1 diet, electrolyte excretion was compared on NaHCO3 vs NaC1 supplements of 200 meq/day. Periods of NaHCO3 and NaC1 (in alternate order for successive patients) lasted 4 days, separated by reequilibration to base-line weight. Mean +/- SEM excretion (ex) of Na, C1, and HCO3 and deltaCcr and deltaweight (day 4-1) are compared below for the 4th day of NaC1 vs. NaHCO3 intake. Mean Ccr +/-SEM on day 4 of NaC1 and NaHCO3 were 10.8 +/-1.6 and 9.0 +/-1.4 ml/min, respectively (P less than 0.02). Mean systolic blood pressure (but not diastolic) increased significantly on NaC1 (P less than 0.05). No significant blood pressure changes were seen on NaHCO3. Net positive HCO3 balance occurred on NaHCO3 as indicated above and reflected a rise in mean serum HCO3 from 19 to 30 meq/liter (day 1 vs. 4) (P less than 0.01). Mechanisms for the greater excretion of Na on NaHCO3 may relate to C1 wasting as noted above on low C1 intake and limited HCO3 reabsorptive capacity. Thus, Na excretion by day 4 was greater on NaHCO3 than on NaHCO3 did Na excretion near intake (210 meq/day).

  17. Dysertacje poświęcone tematyce polskiej, powstałe na Wydziale Filozoficznym Uniwersytetu Wiedeńskiego w latach 1872-1937

    Directory of Open Access Journals (Sweden)

    Aleksandra Wiśniewska

    2010-01-01

    Full Text Available Przedmiot niniejszego artykułu stanowią dysertacje poświęcone Polsce, jej historii i kulturze, powstające na Wydziale Filozoficznym Uniwersytetu Wiedeńskiego w ramach dyscyplin humanistycznych w okresie 1872-1937. Dotychczasowe publikacje na ten temat dotyczą przede wszystkim Polaków zdobywających stopnie naukowe w Wiedniu, brakuje jednak kompletnej informacji bibliograficznej w tym zakresie. W niniejszym opracowaniu za punkt wyjścia przyjęto kryterium przedmiotowe, pragnąc zebrać dysertacje poświęcone tematyce polskiej, niezależnie od pochodzenia ich autora. Na podstawie spisów dysertacji z tego okresu znaleziono 143 prace, w tym najwięcej z historii (95, ponadto ze slawistyki, z geografii, germanistyki, muzykologii, historii sztuki, filozofii oraz antropologii i etnologii. Większości z przytoczonych prac (z pojedynczymi wyjątkami nie uwzględnia jak dotąd retrospektywna Bibliografia polska 1901-1939, ani też Bibliografia polska XIX stulecia Karola Estreichera. Na podstawie mało dotychczas przebadanego źródła wiedzy, jakim są własnoręczne curriculum vitae doktorantów, przechowywane wraz z recenzjami rozpraw w wiedeńskim archiwum, przeanalizowano pochodzenie, drogę życiową i przebieg kariery naukowej niektórych mniej znanych autorów rozpraw. Artykuł prezentuje też wybrane sylwetki wiedeńskich profesorów, pod których kierunkiem powstawały prace poświęcone polskiej tematyce. Całość uzupełnia szczegółowy spis 143 dysertacji, w układzie chronologicznym z podziałem na poszczególne dyscypliny, ze wskazaniem możliwości dotarcia do prac obecnych w zbiorach wiedeńskiej Biblioteki Uniwersyteckiej.

  18. Odpowiedź na pytanie

    Directory of Open Access Journals (Sweden)

    Michel Foucault

    2016-12-01

    Full Text Available Prezentowany artykuł Michela Foucaulta został opublikowany w 1963 roku. Foucault rozwija w nim koncepcję archeologii wiedzy – metody analizy historycznych dyskursów, którą zaprezentuje w sześć lat później w książce o tym właśnie tytule. Artykuł powstał na kanwie pytania wybranego przez autora spośród zadanych mu przez redakcję „Esprit”, które dotyczyło możliwości pojęciowego opracowania przymusu systemu dyskursywnego przy jednoczesnym zaakcentowaniu nieciągłości w jego obrębie a tym samym możliwości twórczego działania w historii ducha. A także, czy tak sformułowana aporia zakładałaby z konieczności zgodę na przymus systemu lub afirmację siły zdolnej do przekształcenia go za pomocą zewnętrznej przemocy? Tekst jest wprawką do sformułowania dojrzałej teorii dyskursu, rodzajem autoanalizy, która pozwala Foucaultowi powiązać własną metodę historyczną z „progresywistyczną polityką” myśli i rozwiązać w ten sposób dylemat pełnej determinacji i wolnego sprawstwa obecny w rozważaniach wielu strukturalistów.

  19. Interaction between Na+/K+-pump and Na+/Ca2+-exchanger modulates intercellular communication

    DEFF Research Database (Denmark)

    Matchkov, Vladimir; Gustafsson, Helena; Rahman, Awahan;

    2007-01-01

    of Na(+)/K(+)-pump activity by removal of extracellular potassium ([K(+)](o)) also uncoupled cells, but only after inhibition of K(ATP) channels. Inhibition of the Na(+)/Ca(2+)-exchange activity by SEA0400 or by a reduction of the equilibrium potential (making it more negative) also uncoupled the cells....... Depletion of intracellular Na(+) and clamping of [Ca(2+)](i) at low concentrations prevented the uncoupling. The experiments suggest that the Na(+)/K(+)-pump may affect gap junction conductivity via localized changes in [Ca(2+)](i) through modulation of Na(+)/Ca(2+)-exchanger activity.......Ouabain, a specific inhibitor of the Na(+)/K(+)-pump, has previously been shown to interfere with intercellular communication. Here we test the hypothesis that the communication between vascular smooth muscle cells is regulated through an interaction between the Na(+)/K(+)-pump and the Na(+)/Ca(2...

  20. Factors affecting heavy metals accumulation in potato tubers / Czynniki wpływające na akumulację metali ciężkich w bulwach ziemniaka

    Directory of Open Access Journals (Sweden)

    Musilova Janette

    2015-09-01

    Full Text Available Badano wpływ wybranych czynników agrochemicznych na akumulację metali ciężkich w bulwach ziemniaka. Gleby uprawne mogą być zanieczyszczone metalami ciężkimi. Pierwiastki, które występują w glebach w formach biodostępnych (mobilnych mogą zostać włączone do obiegu biologicznego, mając tym samym negatywny wpływ na jakość plonów i zdrowie konsumentów/ człowieka. W badanych glebach oznaczono całkowitą zawartość: Zn, Cu, Ni, Pb, Cd oraz udział tych pierwiastków w formach mobilnych. Spośród badanych pierwiastków najbardziej mobilnym metalem był ołów, którego zakres zawartości w formach mobilnych wynosił: 0,100-0,295 mg∙kg-1, przekraczając dopuszczalne wartości dla tego pierwiastka. Zawartość ołowiu w ziemniakach wynosiła: 0.244-0.855 mg∙kg-1 FM. Analiza statystyczna wykazała istotną korelację pomiędzy zawartością pierwiastków w formach mobilnych i ich zawartością w ziemniakach oraz między odczynem badanych gleb, a całkowitą zawartością ołowiu w ziemniakach. Nie zaobserwowano istotnej statystycznie korelacji pomiędzy zawartością próchnicy w glebach a zawartością ołowiu w ziemniakach

  1. Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease

    DEFF Research Database (Denmark)

    Toustrup-Jensen, Mads Schak; Einholm, Anja P.; Schack, Vivien;

    2014-01-01

    The neurological disorders familial hemiplegic migraine type 2 (FHM2), alternating hemiplegia of childhood (AHC), and rapid-onset dystonia parkinsonism (RDP) are caused by mutations of Na+,K+-ATPase α2- and α3-isoforms, expressed in glial and neuronal cells, respectively. Although these disorders...... are distinct, they overlap in phenotypical presentation. Two Na+,K+-ATPase mutations, extending the C-terminus by either 28 residues ("+28" mutation) or an extra tyrosine ("+Y"), are associated with FHM2 and RDP, respectively. We describe here functional consequences of these and other neurological disease......, addressing the question to what extent they cause a change of the intracellular Na+ and K+ concentrations ([Na+]i and [K+]i) in COS cells. C-terminal extension mutants generally showed dramatically reduced Na+ affinity without disturbance of K+ binding, as did other RDP mutants. No phosphorylation from ATP...

  2. Kinetin Reversal of NaCl Effects

    Science.gov (United States)

    Katz, Adriana; Dehan, Klara; Itai, Chanan

    1978-01-01

    Leaf discs of Nicotiana rustica L. were floated on NaCl in the presence of kinetin or abscisic acid. On the 5th day 14CO2 fixation, [3H]leucine incorporation, stomatal conductance, and chlorophyll content were determined. Kinetin either partially or completely reversed the inhibitory effects of NaCl while ABA had no effect. PMID:16660618

  3. Inelastic processes in Na+-Ne, Na+-Ar, Ne+-Na, and Ar+-Na collisions in the energy range 0.5-14 keV

    Science.gov (United States)

    Lomsadze, R. A.; Gochitashvili, M. R.; Kezerashvili, R. Ya.

    2015-12-01

    Absolute cross sections for charge-exchange, ionization, and excitation in Na+-Ne and Na+-Ar collisions were measured in the ion energy range 0.5 -10 keV using a refined version of a capacitor method and collision and optical spectroscopy methods simultaneously in the same experimental setup. Ionization cross sections for Ne+-Na and Ar+-Na collisions are measured at energies of 2 -14 keV using a crossed-beam spectroscopy method. The experimental data and the schematic correlation diagrams are used to analyze and determine the mechanisms for these processes. For the charge-exchange process in Na+-Ar collisions two nonadiabatic regions are revealed and mechanisms responsible for these regions are explained. Structural peculiarity on the excitation function for the resonance lines of argon atoms in Na+-Ar collisions are observed and the possible mechanisms of this phenomenon are explored. The measured ionization cross sections for Na+-Ne and Ne+-Na collisions in conjunction with the Landau-Zener formula are used to determine the coupling matrix element and transition probability in a region of pseudocrossing of the potential curves.

  4. Bullying na Escola: um sofrimento

    Directory of Open Access Journals (Sweden)

    Marlene Silva Sardinha Gurpilhares

    2014-07-01

    Full Text Available O bullying é uma forma de violência presente nas escolas e o termo é utilizado para caracterizar todas as formas de agressões repetitivas psicológicas e físicas, direta ou indiretamente. Esta violência causa sofrimentos, intimidação e medo, sempre numa relação de poder entre pares. Esta pesquisa trata de um estudo do bullying escolar: o que é, como surgiu, como identificá-lo e sua caracterização, conseqüências, causas, o papel da escola, de professores e pais e uma proposta prática que pode ser adotada para sua prevenção e contenção. O objetivo é organizar materiais para leitura dos atores educacionais para uma possível reflexão, através de pesquisas bibliográficas. Esta violência é grave e deveria ser tratada como saúde pública, devido às conseqüências que traz, como queda na aprendizagem, na autoestima e em casos mais graves, até o suicido e outras tragédias. A escola necessita atentar para esse tipo de violência, revendo suas ações em todos os momentos, tendo um olhar integral e diferenciado em relação aos alunos. É fundamental que o bullying não seja tratado como brincadeira de criança e para ser identificado e combatido é necessária uma ação entre a família e todos da escola, que pode ser desenvolvida através de projetos que ajudem a apontar caminhos para a solução do problema. Tais ações devem ser pautadas por constantes debates e reflexões, nas quais o aluno se torne o protagonista. Não existem fórmulas prontas, pois a intervenção deve ser feita através da realidade de cada escola.

  5. Razvitak naselja na kvarnerskim otocima - primjer Dobrinja

    Directory of Open Access Journals (Sweden)

    Marijan Bradanović

    2012-12-01

    Full Text Available Na dosad slabo poznatom i sa stajališta povijesti umjetnosti još posve neobrađenom primjeru Dobrinja na otoku Krku, raspravlja se o razvitku naselja na kvarnerskim otocima. Uz isticanje štetnosti dosad prevladavajućih uopćavanja, karakteristični položaj i razvitak Dobrinja tumače se u širem, komparativnom kontekstu. Analiziraju se prostiranje i obilježja pojedinih dijelova ovog naselja, a naglasak je na vremenu kasnog srednjeg i ranijeg novog vijeka. Tada je najuži dio povijesnog središta Dobrinja poprimio čvrstu, na tlorisnoj osnovi i danas, usprkos opsežnim pregradnjama i arhitektonskim preinakama, jasno uočljivu, urbanu fizionomiju.

  6. Negative electrodes for Na-ion batteries.

    Science.gov (United States)

    Dahbi, Mouad; Yabuuchi, Naoaki; Kubota, Kei; Tokiwa, Kazuyasu; Komaba, Shinichi

    2014-08-07

    Research interest in Na-ion batteries has increased rapidly because of the environmental friendliness of sodium compared to lithium. Throughout this Perspective paper, we report and review recent scientific advances in the field of negative electrode materials used for Na-ion batteries. This paper sheds light on negative electrode materials for Na-ion batteries: carbonaceous materials, oxides/phosphates (as sodium insertion materials), sodium alloy/compounds and so on. These electrode materials have different reaction mechanisms for electrochemical sodiation/desodiation processes. Moreover, not only sodiation-active materials but also binders, current collectors, electrolytes and electrode/electrolyte interphase and its stabilization are essential for long cycle life Na-ion batteries. This paper also addresses the prospect of Na-ion batteries as low-cost and long-life batteries with relatively high-energy density as their potential competitive edge over the commercialized Li-ion batteries.

  7. Anodic Synthesis and Characterization of Na-Pb-O, Na-Pb-Bi-O Crystals

    Institute of Scientific and Technical Information of China (English)

    Li Mei QIU; Fen LIU; Liang Zhong ZHAO

    2005-01-01

    Crystals of Na-Pb-O and Na-Pb-Bi-O were electrosynthesized on the anode from molten salts. The resulting crystals have a hexagonal structure, in which the base ions (Pb and Bi) are in high oxidation states. By using KOH/NaOH (atomic ratio K:Na=1:1) mixture as a flux,incorporation of K ions into the lattice is inhibited while incorporation of Bi ions is enhanced. The magnetic measurement shows that the Na-Pb-Bi-O crystals are dominated by diamagnetism.

  8. Barroco: A tempestade na Biblioteca

    Directory of Open Access Journals (Sweden)

    Diego Cervelin

    2008-12-01

    Full Text Available Desde que Heinrich Wölfflin, nos últimos vinte anos do século XIX, se interessou por trazer à tona as formas arquitetônicas do século XVII conferindo-lhes caráter autônomo de estilo histórico determinável, não é nenhuma novidade que os estudos sobre o barroco pudessem polarizar – quase sempre em um tom colérico – os pesquisadores da arte e da cultura. Em terras do Brasil, não chega a ser de todo descabido recordar a severíssima crítica operada por Sérgio Buarque de Holanda em Raízes do Brasil. O livro, que pretende detectar a avalanche de equívocos que teria povoado o passado nacional com as vistas voltadas para a concretização de um projeto de emancipação e progresso na linha da história brasileira, apresenta em seu quarto capítulo uma impugnação explícita ao passado colonial.

  9. Barroco: A tempestade na Biblioteca

    Directory of Open Access Journals (Sweden)

    Diego Cervelin

    2008-10-01

    Full Text Available http://dx.doi.org/10.5007/1984-784x.2008v8n12p167 Desde que Heinrich Wölfflin, nos últimos vinte anos do século XIX, se interessou por trazer à tona as formas arquitetônicas do século XVII conferindo-lhes caráter autônomo de estilo histórico determinável, não é nenhuma novidade que os estudos sobre o barroco pudessem polarizar – quase sempre em um tom colérico – os pesquisadores da arte e da cultura. Em terras do Brasil, não chega a ser de todo descabido recordar a severíssima crítica operada por Sérgio Buarque de Holanda em Raízes do Brasil. O livro, que pretende detectar a avalanche de equívocos que teria povoado o passado nacional com as vistas voltadas para a concretização de um projeto de emancipação e progresso na linha da história brasileira, apresenta em seu quarto capítulo uma impugnação explícita ao passado colonial.

  10. Terapia de linguagem na afasia

    Directory of Open Access Journals (Sweden)

    Mauro Spinelli

    1977-12-01

    Full Text Available A terapia da linguagem na afasia foi estudada em 15 pacientes, 8 do sexo masculino e 7 do sexo feminino; a idade variou de menos de 10 anos a mais de 50 anos; em 11 casos a afasia era sequela de acidente vascular cerebral e, em 4, de traumatismo crânio-encefálico. Quanto ao tipo de afasia, 5 pacientes apresentavam déficits predominantemente de expressão e 10 apresentavam déficits receptivos e expressivos em graus equiparáveis. Em 6 casos a terapia foi iniciada dentro dos 3 primeiros meses de instalação do quadro; nos restantes foi iniciada mais tardiamente. Dos 15 pacientes, 11 apresentaram evolução satisfatória, a qual não depndeu do grau de afasia, do tipo de afasia, da idade do paciente, do tipo de patologia e do intervalo entre a instalação do quadro afásico e o início da terapia. A terapia da linguagem no paciente afásico é efetiva, o prognóstico não pode ser feito a priori. Somente a evolução do caso com sua retestagem criteriosa poderá dar dados realmente úteis para se falar em evolução.

  11. Breakup studies with {sup 23}Na

    Energy Technology Data Exchange (ETDEWEB)

    Jarvis, N.S.; Watson, D.L.; Gyapong, G.J.; Jones, C.D. [University of York, York YO1 5DD (United Kingdom); Bennett, S.J.; Freer, M.; Fulton, B.R.; Karban, O.; Murgatroyd, J.T.; Tungate, G. [University of Birmingham, Birmingham, B15 2TT (United Kingdom); Rae, W.D.M.; Smith, A.E. [University of Oxford, Oxford, OX1 3RA (United Kingdom)

    1995-05-01

    The breakup of {sup 23}Na nuclei into {sup 11}B+{sup 12}C and of {sup 24}Mg nuclei into {sup 12}C+{sup 12}C has been studied using the reactions {sup 12}C({sup 23}Na,{sup 11}B{sup 12}C){sup 12}C and {sup 12}C({sup 23}Na,{sup 12}C{sup 12}C){sup 11}B. Clear evidence was found for the breakup of the {sup 23}Na and {sup 24}Mg nuclei into the ground states of both fragments. The yieldrotect from the {sup 12}C({sup 23}Na,{sup 11}B{sub g.s.}{sup 12}C{sub g.s.}){sup 12}C{sub g.s.} reaction was concentrated in the region of excitationrotect energy in {sup 23}Na between 24 and 28 MeV and fragmented among a number of states. Therotect {sup 12}C({sup 23}Na,{sup 12}C{sub g.s.} {sup 12}C{sub g.s.)}{sup 11}B{sub g.s.} reaction was found to proceed chiefly via broad states at 22.1 and 23.9 MeV in {sup 24}Mg.

  12. Gasotransmitters: novel regulators of epithelial na(+) transport?

    Science.gov (United States)

    Althaus, Mike

    2012-01-01

    The vectorial transport of Na(+) across epithelia is crucial for the maintenance of Na(+) and water homeostasis in organs such as the kidneys, lung, or intestine. Dysregulated Na(+) transport processes are associated with various human diseases such as hypertension, the salt-wasting syndrome pseudohypoaldosteronism type 1, pulmonary edema, cystic fibrosis, or intestinal disorders, which indicate that a precise regulation of epithelial Na(+) transport is essential. Novel regulatory signaling molecules are gasotransmitters. There are currently three known gasotransmitters: nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H(2)S). These molecules are endogenously produced in mammalian cells by specific enzymes and have been shown to regulate various physiological processes. There is a growing body of evidence which indicates that gasotransmitters may also regulate Na(+) transport across epithelia. This review will summarize the available data concerning NO, CO, and H(2)S dependent regulation of epithelial Na(+) transport processes and will discuss whether or not these mediators can be considered as true physiological regulators of epithelial Na(+) transport biology.

  13. Gasotransmitters: Novel regulators of epithelial Na+ transport?

    Directory of Open Access Journals (Sweden)

    Mike eAlthaus

    2012-04-01

    Full Text Available The vectorial transport of Na+ across epithelia is crucial for the maintenance of Na+ and water homeostasis in organs such as the kidneys, lung or intestine. Dysregulated Na+ transport processes are associated with various human diseases such as hypertension, the salt-wasting syndrome pseudohypoaldosteronism type 1, pulmonary edema, cystic fibrosis or intestinal disorders, which indicate that a precise regulation of epithelial Na+ transport is essential. Novel regulatory signaling molecules are gasotransmitters. There are currently three known gasotransmitters: nitric oxide (NO, carbon monoxide (CO and hydrogen sulfide (H2S. These molecules are endogenously produced in mammalian cells by specific enzymes and have been shown to regulate various physiological processes. There is a growing body of evidence, which indicates that gasotransmitters may also regulate Na+ transport across epithelia. This review will summarize the available data concerning NO, CO and H2S dependent regulation of epithelial Na+ transport processes and will discuss whether or not these mediators can be considered as true physiological regulators of epithelial Na+ transport biology.

  14. Aspectos clínicos e evolutivos da hidrocefalia na neurocisticercose Clinical and evolutive aspects of hydrocephalus in neurocysticercosis

    Directory of Open Access Journals (Sweden)

    Svetlana Agapejev

    2007-09-01

    Full Text Available Com o propósito de analisar os aspectos clínicos da hidrocefalia (HDC na neurocisticercose (NCC, realizou-se o estudo retrospectivo de 47 prontuários de pacientes com HDC e NCC. Verificou-se que 70,2% eram homens, entre 21 e 50 anos. A hipertensão intracraniana (HIC ocorreu em todos os pacientes, cefaléia (CEF em 89,4%, meningoencefalite (ME em 80,8% e distúrbios psíquicos (PSI em 74,5%. A síndrome liquórica da NCC foi detectada em 65,9% pacientes. Além da HDC, as tomografias computadorizadas de crânio (TC mostraram lesões císticas e edema cerebral difuso em 59,6% cada, calcificações em 55,3%. Dos 41 pacientes (87,2% com derivação ventriculoperitoneal (DVP, em 22 (53,7% deles foram necessárias uma a sete revisões/paciente (média=3. A evolução foi satisfatória em 51,1% e fatal em 31,9%. Conclui-se que a hidrocefalia é mais comum no sexo masculino em idade produtiva, tendo a HIC, CEF, MN e PSI como manifestações freqüentes e que, a necessidade de revisões de DVP, piora o prognóstico.With the purpose to verify clinical aspects of hydrocephalus (HC in patients with neurocysticercosis (NCC, a retrospective study of 47 patients was performed. The majority of patients (70.2% were men aging 21-50 years. Intracranial hypertension (ICH occurred in all patients, headache (HA in 42 (89.4%, meningoencephalitis (ME in 38 (80.8% and psychiatric disorders (PD in 34 (72.3%. The cerebrospinal fluid syndrome of NCC was detected in 31 patients (65.9%. In addition to HC, computed tomography (CT scans showed cystic lesions in 28 (59.6% patients, diffuse brain edema also in 28 (59.6%, and calcifications in 26 (55.3%. Shunts were inserted in 41 (87.2% patients and 22 (53.7% of them were submitted to 1-7 surgical revision/patient (mean=3 that were higher (mean=4 in those who died than in survivors (mean=2. Evolution was satisfactory in 24 (51.1% patients and fatal in 15 (31.9%. It is possible to conclude that, in patients with NCC, HC occurs

  15. Uwagi teoretyczne na temat zmiany kodu w monologach starowierców mieszkających w Polsce

    Directory of Open Access Journals (Sweden)

    Michał Głuszkowski

    2015-12-01

    Full Text Available Theoretical remarks on code-switching in monologues of the Old Believers living in Poland The Old Believers living in Poland are a bilingual community. Although they managed to maintain their religion, culture and language through ages, their language situation as well as the structure of the dialect have been undergoing severe changes. In spite of Polish loan translations and borrowings present in the Russian dialect, the Old Believers tend to switch the code between sentences and inside of them. The article is an approach to find an appropriate theoretical approach to characterize the phenomenon of code switching and code mixing in monologues, i.e. these cases of switching which are caused neither by the change of interlocutor nor by the change of communicative situation.   Uwagi teoretyczne na temat zmiany kodu w monologach starowierców mieszkających w Polsce Mieszkający w Polsce staroobrzędowcy są społecznością dwujęzyczną. Choć na przestrzeni kilku stuleci udało im się zachować swoją religię, kulturę i język, ich sytuacja językowa oraz struktura dialektu wciąż podlegają poważnym zmianom. Oprócz zapożyczeń i kalk z języka polskiego przejawem tych zmian jest tendencja do przełączania kodów pomiędzy zdaniami i wewnątrz nich. Artykuł stanowi próbę znalezienia podejścia teoretycznego, które byłoby odpowiednie do opisu zjawisk przełączania i mieszania kodów w monologach, czyli tych przypadków zmiany języka wypowiedzi, które nie są spowodowane zmianą rozmówcy ani sytuacji komunikacyjnej.

  16. NMR studies on Na+ transport in Synechococcus PCC 6311

    Science.gov (United States)

    Nitschmann, W. H.; Packer, L.

    1992-01-01

    The freshwater cyanobacterium Synechococcus PCC 6311 is able to adapt to grow after sudden exposure to salt (NaCl) stress. We have investigated the mechanism of Na+ transport in these cells during adaptation to high salinity. Na+ influx under dark aerobic conditions occurred independently of delta pH or delta psi across the cytoplasmic membrane, ATPase activity, and respiratory electron transport. These findings are consistent with the existence of Na+/monovalent anion cotransport or simultaneous Na+/H+ +anion/OH- exchange. Na+ influx was dependent on Cl-, Br-, NO3-, or NO2-. No Na+ uptake occurred after addition of NaI, NaHCO3, or Na2SO4. Na+ extrusion was absolutely dependent on delta pH and on an ATPase activity and/or on respiratory electron transport. This indicates that Na+ extrusion via Na+/H+ exchange is driven by primary H+ pumps in the cytoplasmic membrane. Cells grown for 4 days in 0.5 m NaCl medium, "salt-grown cells," differ from control cells by a lower maximum velocity of Na+ influx and by lower steady-state ratios of [Na+]in/[Na+]out. These results indicate that cells grown in high-salt medium increase their capacity to extrude Na+. During salt adaptation Na+ extrusion driven by respiratory electron transport increased from about 15 to 50%.

  17. PLESNO USTVARJANJE NA PODLAGI LITERARNEGA BESEDILA

    OpenAIRE

    Krajnc, Jožica; Zaponšek, Mojca

    2009-01-01

    Diplomsko delo z naslovom Plesno ustvarjanje na podlagi literarnega besedila je zapisano v okviru plesnega ustvarjanja otrok ob slikanici Bravo, putka!. V teoretičnem delu je obravnavan ples v povezavi z njegovim izražanjem in vzgojo. Ob tem je posebej izpostavljena estetika v plesu, sodobni ples ter balet. Poudarek je tudi na improviziranju in oblikovanju ter na dihanju in ritmu. Ob tem sta izpostavljena glasba in književnost kot pomembna motivacijska dejavnika. Teoretični del je nadgrajen s...

  18. Nalaz tombusvirusa na vrsti Erigeron canadensis L.

    OpenAIRE

    Jeknić, Zoran; Erić, Živojin; Grbelja, Julijana

    1988-01-01

    Iz listova zaraženih primjeraka korovne biljke Erigeron canadensis L. koji su rasli na nekoliko lokaliteta u Sarajevu izoliran je virus iz skupine tombusvirusi. Identifikacija virusa izvršena je na osnovi reakcije pokusnih biljaka, analize ultratankih presjeka kroz zaraženo tkivo, morfologije i veličine virusnih čestica, te na osnovi seroloških reakcija metodom dvostruke imunodifuzije u agarskom gelu i čvrsto fazne imunoelektronske mikroskopije (SPIEM). U serološkim pokusima upotrijebljen je ...

  19. Kornati na starim geografskim i pomorskim kartama

    OpenAIRE

    Faričić, Josip; Simičić, Zdenko

    2005-01-01

    U radu se na temelju analize kartografskih izvora analizira historijsko-geografski razvitak Kornatskih otoka, koji čine najbrojniju skupinu među hrvatskim otocima. Stare se karte koriste ponajprije kao sredstvo geografskih istraživanja, koje u nužnoj korelaciji s istovremenim povijesnim pisanim izvorima te modernim topografskim i pomorskim kartama čine osnovu za oblikovanje istraživačke platforme na kojoj se mogu graditi relevantni znanstveni rezultati. Na temelju starih karata moguće je, uz ...

  20. EKSPERIMENTALNA ANALIZA VIBRACIJ NA PRALNI GRUPI

    OpenAIRE

    Kozel, Rok

    2012-01-01

    Diplomsko delo se ukvarja z vibracijami pralnega stroja. Eksperimentalno analizo smo opravili na laboratorijskem preizkuševališču, kjer je pralna grupa obešena na namenskem ogrodju. Na pralni grupi sta nameščena pospeškomera ADXL345, ki sta s serijsko SPI komunikacijo povezana z NI PXI-7841R karto. NI PXI-7841R karta je v ohišju NI PXI 1003 in je povezana z računalnikom. Pralna grupa je opremljena tudi z BLAC motorjem, s katerim operira razvojna plošča NEXYS 2. Vse skupaj nadziramo preko raču...

  1. PERUBAHAN KEKERASAN DENTIN PADA SALURAN AKAR SETELAH APLIKASI NaOCl 3%, KOMBINASI NaOCl 3% - EDTA 17%, DAN NaOCl 3% - KLORHEKSIDIN 2%

    OpenAIRE

    ALFINA, RISCA

    2014-01-01

    2014 PERUBAHAN KEKERASAN DENTIN PADA SALURAN AKAR SETELAH APLIKASI NaOCl 3%, KOMBINASI NaOCl 3% - EDTA 17%, DAN NaOCl 3% - KLORHEKSIDIN 2% Risca Alfina Fakultas Kedokteran Gigi Universitas Hasanuddin ABSTRAK Latar Belakang: Beberapa larutan irigasi yang biasa digunakan saat pembersihan dan preparasi saluran akar yaitu sodium hypochlorite (NaOCl), klorheksidin, dan ethylenediaminetetraacetic acid (EDTA). Larutan irigasi tersebut berinteraks...

  2. Chemical thermodynamics of metallic alloy formation. Final report. [Na-K; Mg-Cd; NaCl-NaBr

    Energy Technology Data Exchange (ETDEWEB)

    Wallace, W.E.

    1951-12-01

    Methods and apparatus required in determining the heats of formation at 25/sup 0/C of sodium-potassium alloys, magnesium-cadmium alloys and sodium chloride-sodium bromide ionic solid solutions have been developed. Method for determining free energies of formation of magnesium-cadmium alloys at elevated temperatures has been developed. Apparatus for determining the specific heats of magnesium-cadmium alloys at low temperatures has been prepared. The heat of reaction of pure potassium with water was determined. Provisional values for the heats of formation of four sodium-potassium alloys were obtained. A density-composition curve for magnesium-cadmium alloys was constructed. Heats of formation of nine NaCl-NaBr solid solutions were measured and the data used to calculate thermodynamically the phase diagram describing the mutual solid solubility of the two salts. Lattice spacings of NaCl-NaBr solid solutions were determined by x-ray diffraction techniques and the results compared with Vegnard's Rule and the additivity rule for molar volumes. A theoretical study based upon the Born-Mayer model for ionic solids was made to attempt to account for the variation with composition of the energy and lattice spacings of the alkali halide solid solutions. Comparison of results for the NaCl-NaBr system with those obtained in a similar study of Fontell indicated some discrepancies which were removed by a retreatment of Fontell's data.

  3. Perfil nutricional na artrite reumatoide

    Directory of Open Access Journals (Sweden)

    Rachel Simone Maccarini Zarpellon

    2014-01-01

    Full Text Available Objetivo: Estudar o perfil nutricional de pacientes com artrite reumatoide (AR. Métodos: Estudo transversal observacional de 102 pacientes com AR. Os pacientes foram estudados para dados clínicos, demográficos, sorológicos, atividade de doença e perfil nutricional. Neste último incluiu-se a medida do índice de massa corporal (IMC, relação quadril/cintura, pregas cutâneas bicipitais (PCB e sua adequação; prega cutânea tricipital (PCT e sua adequação e circunferência muscular do braço (CMB e sua adequação. Estudos de associação foram feitos usando os testes de Fisher e qui-quadrado para dados nominais e teste t não pareado e Mann Whitney para dados numéricos. Para cálculo de correlação usou-se o teste de Spearman. Resultado: Na amostra existiam 14/102 homens e 88/102 mulheres com idade média de 52,1 ± 11,5 anos e duração média de doença de 10,6 ± 7,4 anos. A relação cintura/quadril média era de 0,92 ± 0,07. De acordo com IMC, 30,3% tinham peso normal e 65,5% tinham peso acima do normal. De acordo com PCB, 74,5% eram normais e 25,5% tinham depleção; de acordo com a PCT, 83,3% eram normais e 16,7% tinham depleção. Associação de variáveis nutricionais com gênero, fator reumatoide, nódulos e atividade da doença não mostraram diferenças (p = NS exceto, por uma relação cintura/quadril menor em indivíduos com nódulos (p = 0,02 e uma correlação modesta da PCT com a duração de doença (p = 0,02; R = 0,22; 95% IC = 0,01-0,40. Conclusão: Existe uma alta prevalência de sobrepeso e obesidade em artrite reumatoide e uma pequena frequência de depleção muscular.

  4. NaCl (mM)

    African Journals Online (AJOL)

    Yomi

    2012-04-03

    Apr 3, 2012 ... MDA was determined for aerial parts following a published procedure .... MDA, a generic biomarker for membrane damage. (Elkahoui et al. ..... acid and essential oil composition of sage (Salvia officinalis L,) leaves under NaCl ...

  5. Aerobe zuivering van vergiste varkensdrijfmest na aanzuren

    NARCIS (Netherlands)

    Goossens, W.

    1988-01-01

    Onderzoeksverslag betreffende een vorm van nazuivering, bedoeld om de vluchtige componenten (vetzuren), die na vergisting nog aanwezig zijn, te oxideren. De mest wordt belucht onder toevoeging van zwavelzuur. Het zure milieu voorkomt ammoniakemissie tijdens het beluchten. Bovendien zullen in volgend

  6. Erythrocyte 22Na+ influx in hypertension

    Energy Technology Data Exchange (ETDEWEB)

    Shalev, O.; Eaton, J.W.; Ben-Ishay, D.

    1984-01-01

    We assessed 22Na+ uptake by erythrocytes (RBC) from 38 individuals with essential hypertension and 37 healthy controls. All subjects were male, white, non-obese and with normal renal function, obviating sex, race, hormonal, ponderal and renal factors known to influence RBC Na+ handling. The mean +/- sem 22Na+ uptake of the patients was 284 +/- 16 mumole/liter RBC/hour while that of normal controls was 249 +/- 11 mumole/liter RBC/hour; although the difference reached borderline significance, individual values showed considerable overlap. Consequently, in our population, RBC 22Na+ uptake is not a reliable marker for essential hypertension. We believe that previous studies should be reassessed with regard to patients' characteristics and future studies employ rigorous criteria in selection of subjects.

  7. Waardevolle lessen na overstromingen in Thailand

    NARCIS (Netherlands)

    Jonkman, S.N.; Van der Meer, M.T.; Hardeman, B.

    2012-01-01

    Een verkenningsmissie na de overstromingen in Thailand in 2011 heeft meer inzicht gegeven in het functioneren van het waterkeringssysteem tijdens de ramp. Dijken bleken kwetsbaar door overloop, evenals de aansluitingen tussen dijken en constructies.

  8. Painful Na-channelopathies: an expanding universe.

    Science.gov (United States)

    Waxman, Stephen G

    2013-07-01

    The universe of painful Na-channelopathies--human disorders caused by mutations in voltage-gated sodium channels--has recently expanded in three dimensions. We now know that mutations of sodium channels cause not only rare genetic 'model disorders' such as inherited erythromelalgia and channelopathy-associated insensitivity to pain but also common painful neuropathies. We have learned that mutations of NaV1.8, as well as mutations of NaV1.7, can cause painful Na-channelopathies. Moreover, recent studies combining atomic level structural models and pharmacogenomics suggest that the goal of genomically guided pain therapy may not be unrealistic. Copyright © 2013 Elsevier Ltd. All rights reserved.

  9. Hydrogen-fluorine exchange in NaBH4-NaBF4.

    Science.gov (United States)

    Rude, L H; Filsø, U; D'Anna, V; Spyratou, A; Richter, B; Hino, S; Zavorotynska, O; Baricco, M; Sørby, M H; Hauback, B C; Hagemann, H; Besenbacher, F; Skibsted, J; Jensen, T R

    2013-11-07

    Hydrogen-fluorine exchange in the NaBH4-NaBF4 system is investigated using a range of experimental methods combined with DFT calculations and a possible mechanism for the reactions is proposed. Fluorine substitution is observed using in situ synchrotron radiation powder X-ray diffraction (SR-PXD) as a new Rock salt type compound with idealized composition NaBF2H2 in the temperature range T = 200 to 215 °C. Combined use of solid-state (19)F MAS NMR, FT-IR and DFT calculations supports the formation of a BF2H2(-) complex ion, reproducing the observation of a (19)F chemical shift at -144.2 ppm, which is different from that of NaBF4 at -159.2 ppm, along with the new absorption bands observed in the IR spectra. After further heating, the fluorine substituted compound becomes X-ray amorphous and decomposes to NaF at ~310 °C. This work shows that fluorine-substituted borohydrides tend to decompose to more stable compounds, e.g. NaF and BF3 or amorphous products such as closo-boranes, e.g. Na2B12H12. The NaBH4-NaBF4 composite decomposes at lower temperatures (300 °C) compared to NaBH4 (476 °C), as observed by thermogravimetric analysis. NaBH4-NaBF4 (1:0.5) preserves 30% of the hydrogen storage capacity after three hydrogen release and uptake cycles compared to 8% for NaBH4 as measured using Sievert's method under identical conditions, but more than 50% using prolonged hydrogen absorption time. The reversible hydrogen storage capacity tends to decrease possibly due to the formation of NaF and Na2B12H12. On the other hand, the additive sodium fluoride appears to facilitate hydrogen uptake, prevent foaming, phase segregation and loss of material from the sample container for samples of NaBH4-NaF.

  10. Positron-impact ionization of Na

    Energy Technology Data Exchange (ETDEWEB)

    Mukherjee, K.K. (Jawahar Navodaya Vidyalaya, Ramchandraghat, West Tripura 799207, Tripura (India)); Singh, N.R. (Thambal Marik College, Oinam, Bishanpur, Manipur (India)); Choudhury, K.B. (Department of Physics, Jadavpur University, Calcutta 700032, West Bengal (India)); Mazumdar, P.S. (Department of Physics, Manipur University, Canchipur, Imphal 795003, Manipur (India))

    1992-07-01

    In this paper we present the total cross sections for the positron-impact ionization of Na in the range 8--30 eV of the energy of the incident positron. Calculations are done by using a distorted-wave approximation incorporating the effects of screening and distortion. The present results are compared with the experimental results for the electron-impact ionization of Na.

  11. IZDELAVA IN VODENJE AVTONOMNEGA VOZILA NA GOSENICAH

    OpenAIRE

    Obal, Aleš

    2012-01-01

    V Diplomskem delu je opisan postopek izdelave kontrolno nadzornega sistema za vodenje robota po prostoru. Ključni deli tega sistema so senzorji za merjenje orientacije in pozicije vozila na mikrokrmilniškem sistemu. Vozilu smo dodali komunikacijo z osebnim računalnikom za oddaljen nadzor in na koncu povzeli še program, ki smo ga napisali v mikroC programskem okolju.

  12. Assessment of Impact of the Rheological Parameters Change on Sensitivity of the Asphalt Strain Based on the Test Results / Ocena Wpływu Zmiany Parametrów Reologicznych Na Wrażliwość Deformacji Mieszanek Mineralno - Asfaltowych Na Podstawie Wyników Badań

    Science.gov (United States)

    Kurpiel, Artur; Wysokowski, Adam

    2015-03-01

    określić parametry oparte o różne teorie pełzania a szczególnie cenne parametry reologiczne w oparciu o wybrane modele lepkosprężyste [1]. Parametry z modeli lepkosprężystych są miarodajnymi wskaźnikami obrazującymi odporność mieszanek na deformacje. Można za ich pomocą prognozować głębokości koleiny w przyjętym modelu reologicznym [1]. W niniejszym artykule przedstawiono jaki wpływ na głębokość koleiny mają różne wartości parametrów reologicznych z analizowanego modelu lepkosprężystego oraz wpływ parametrów na kształt i przebieg krzywej pełzania. Przedstawione w artykule mieszanki mineralno - asfaltowe charakteryzują się zmiennymi parametrami reologicznymi, zatem trudno jest określić, który parametr decyduje o wielkości odkształcenia danej mieszanki. Mając na uwadze powyższe, w artykule podjęto próbę analizy zmiany wartości odkształcenia mieszanki mineralno - asfaltowej przy zmianie jednego oraz dwóch parametrów w danym modelu reologicznym - w tym przypadku - Bürgersa.

  13. Elastic Coulomb breakup of $^{34}$Na

    CERN Document Server

    Singh, G; Chatterjee, R

    2016-01-01

    Purpose : The aim of this paper is to study the elastic Coulomb breakup of $^{34}$Na on $^{208}$Pb to give us a core of $^{33}$Na with a neutron and in the process we try and investigate the one neutron separation energy and the ground state configuration of $^{34}$Na. Method : A fully quantum mechanical Coulomb breakup theory within the architecture of post-form finite range distorted wave Born approximation extended to include the effects of deformation is used to research the elastic Coulomb breakup of $^{34}$Na on $^{208}$Pb at 100 MeV/u. The triple differential cross-section calculated for the breakup is integrated over the desired components to find the total cross-section, momentum and angular distributions as well as the average momenta, along with the energy-angular distributions. Results : The total one neutron removal cross-section is calculated to test the possible ground state configurations of $^{34}$Na. The average momentum results along with energy-angular calculations indicate $^{34}$Na to ha...

  14. Efeitos imediatos da MWM na dor, amplitude de movimento e funcionalidade, na osteoartrite da anca.

    OpenAIRE

    Beselga, Carlos

    2014-01-01

    Introdução: A mobilização com movimento (MWM), segundo o Conceito Mulligan tem apresentado bons resultados na melhoria da dor, amplitude de movimento e funcionalidade em diversas disfunções. No entanto, existem poucos estudos sobre a articulação da anca e, até este momento, não foi avaliada a sua efetividade em indivíduos com osteoartrite da anca. Objectivo(s): Avaliar os efeitos imediatos da técnica de MWM na dor, na amplitude de movimento e na função física em indivíduos com ...

  15. Glutamate Water Gates in the Ion Binding Pocket of Na+ Bound Na+, K+-ATPase

    Science.gov (United States)

    Han, Minwoo; Kopec, Wojciech; Solov’yov, Ilia A.; Khandelia, Himanshu

    2017-01-01

    The dynamically changing protonation states of the six acidic amino acid residues in the ion binding pocket of the Na+, K+ -ATPase (NKA) during the ion transport cycle are proposed to drive ion binding, release and possibly determine Na+ or K+ selectivity. We use molecular dynamics (MD) and density functional theory (DFT) simulations to determine the protonation scheme of the Na+ bound conformation of NKA. MD simulations of all possible protonation schemes show that the bound Na+ ions are most stably bound when three or four protons reside in the binding sites, and that Glu954 in site III is always protonated. Glutamic acid residues in the three binding sites act as water gates, and their deprotonation triggers water entry to the binding sites. From DFT calculations of Na+ binding energies, we conclude that three protons in the binding site are needed to effectively bind Na+ from water and four are needed to release them in the next step. Protonation of Asp926 in site III will induce Na+ release, and Glu327, Glu954 and Glu779 are all likely to be protonated in the Na+ bound occluded conformation. Our data provides key insights into the role of protons in the Na+ binding and release mechanism of NKA. PMID:28084301

  16. Sementes geneticamente modificadas: seguranca e racionalidade na adocao de transgenicos no Brasil e na Argentina

    National Research Council Canada - National Science Library

    Fuck, Marcos Paulo; Bonacelli, Maria Beatriz

    2009-01-01

    Esse artigo analisa as principais questoes relacionadas ao processo de introducao de sementes geneticamente modificadas no Brasil e na Argentina, com especial atencao as variedades de soja transgenica...

  17. Elastic Coulomb breakup of 34Na

    Science.gov (United States)

    Singh, G.; Shubhchintak, Chatterjee, R.

    2016-08-01

    Background: 34Na is conjectured to play an important role in the production of seed nuclei in the alternate r -process paths involving light neutron rich nuclei very near the β -stability line, and as such, it is important to know its ground state properties and structure to calculate rates of the reactions it might be involved in, in the stellar plasma. Found in the region of `island of inversion', its ground state might not be in agreement with normal shell model predictions. Purpose: The aim of this paper is to study the elastic Coulomb breakup of 34Na on 208Pb to give us a core of 33Na with a neutron and in the process we try and investigate the one neutron separation energy and the ground state configuration of 34Na. Method: A fully quantum mechanical Coulomb breakup theory within the architecture of post-form finite range distorted wave Born approximation extended to include the effects of deformation is used to research the elastic Coulomb breakup of 34Na on 208Pb at 100 MeV/u. The triple differential cross section calculated for the breakup is integrated over the desired components to find the total cross-section, momentum, and angular distributions as well as the average momenta, along with the energy-angular distributions. Results: The total one neutron removal cross section is calculated to test the possible ground state configurations of 34Na. The average momentum results along with energy-angular calculations indicate 34Na to have a halo structure. The parallel momentum distributions with narrow full widths at half-maxima signify the same. Conclusion: We have attempted to analyze the possible ground state configurations of 34Na and in congruity with the patterns in the `island of inversion' conclude that even without deformation, 34Na should be a neutron halo with a predominant contribution to its ground state most probably coming from 33Na(3 /2+)⊗ 2 p3 /2ν configuration. We also surmise that it would certainly be useful and rewarding to test our

  18. Działania krymskotatarskiego ruchu narodowowyzwoleńczego w warunkach aneksji Krymu (na przykładzie blokady półwyspu

    Directory of Open Access Journals (Sweden)

    Oksana Voytyuk

    2016-08-01

    Full Text Available The actions of Crimean Tatars national liberation movement under сonditions of annexation of the Crimea (example of Crimea blockade In 2015, due to the rapidly changing political and economic situation in the world, the issue of annexation of the Crimea gave way to such news as the political situation in Syria, and Russia's participation in hostilities in this country, the imposition of sanctions on Russia and their impact on the Russian economy, falling oil prices and its effects, the situation with refugees in the European Union. To draw attention to the problem of the annexation of the Crimea and Crimean Tatars Mejlis and its chairman Refat Chubarov and political leader of the Crimean Tatars Mustafa Dzhemilev initiated a peace action of blockade of Crimea. Blockade had two stages – transporto and food blockade and energy blockade. The action ended with the start of 2016 year. Regardless that Crimean Tatars failed to achieve the main goal - to release all political prisoners, blockade showed how high there is peninsula’s dependence from Ukraine's economy.   Działania krymskotatarskiego ruchu narodowowyzwoleńczego w warunkach aneksji Krymu (na przykładzie blokady półwyspu W 2015 roku, w związku z dynamicznie zmieniającą się sytuacją polityczną i gospodarczą na świecie, kwestia aneksji Krymu ustąpiła miejsca takim wiadomościom jak sytuacja w Syrii i udział Rosji w działaniach wojennych na terenie tego kraju, nałożenie sankcji na Rosję oraz ich wpływ na rosyjską gospodarkę, spadek cen ropy naftowej i jego skutki, sytuacja z uchodźcami w Unii Europejskiej. Celem zwrócenia uwagi na aneksję Krymu i problem Tatarów Krymskich, Medżlis z siedzibą w Kijowie przewodniczącym Refatem Czubarowym i politycznym przywódcą Tatarów Krymskich Mustafą Dżemilewym inicjowali bezterminową pokojową akcję blokady Krymu. Blokada miała dwa etapy – transportowo-towarowy i energetyczny. Akcja zakończyła się wraz z rozpocz

  19. Quasi-solid state rechargeable Na-CO2 batteries with reduced graphene oxide Na anodes.

    Science.gov (United States)

    Hu, Xiaofei; Li, Zifan; Zhao, Yaran; Sun, Jianchao; Zhao, Qing; Wang, Jianbin; Tao, Zhanliang; Chen, Jun

    2017-02-01

    Na-CO2 batteries using earth-abundant Na and greenhouse gas CO2 are promising tools for mobile and stationary energy storage, but they still pose safety risks from leakage of liquid electrolyte and instability of the Na metal anode. These issues result in extremely harsh operating conditions of Na-CO2 batteries and increase the difficulty of scaling up this technology. We report the development of quasi-solid state Na-CO2 batteries with high safety using composite polymer electrolyte (CPE) and reduced graphene oxide (rGO) Na anodes. The CPE of PVDF-HFP [poly(vinylidene fluoride-co-hexafluoropropylene)]-4% SiO2/NaClO4-TEGDME (tetraethylene glycol dimethyl ether) has high ion conductivity (1.0 mS cm(-1)), robust toughness, a nonflammable matrix, and strong electrolyte-locking ability. In addition, the rGO-Na anode presents fast and nondendritic Na(+) plating/stripping (5.7 to 16.5 mA cm(-2)). The improved kinetics and safety enable the constructed rGO-Na/CPE/CO2 batteries to successfully cycle in wide CO2 partial pressure window (5 to 100%, simulated car exhaust) and especially to run for 400 cycles at 500 mA g(-1) with a fixed capacity of 1000 mA·hour g(-1) in pure CO2. Furthermore, we scaled up the reversible capacity to 1.1 A·hour in pouch-type batteries (20 × 20 cm, 10 g, 232 Wh kg(-1)). This study makes quasi-solid state Na-CO2 batteries an attractive prospect.

  20. Quasi–solid state rechargeable Na-CO2 batteries with reduced graphene oxide Na anodes

    Science.gov (United States)

    Hu, Xiaofei; Li, Zifan; Zhao, Yaran; Sun, Jianchao; Zhao, Qing; Wang, Jianbin; Tao, Zhanliang; Chen, Jun

    2017-01-01

    Na-CO2 batteries using earth-abundant Na and greenhouse gas CO2 are promising tools for mobile and stationary energy storage, but they still pose safety risks from leakage of liquid electrolyte and instability of the Na metal anode. These issues result in extremely harsh operating conditions of Na-CO2 batteries and increase the difficulty of scaling up this technology. We report the development of quasi–solid state Na-CO2 batteries with high safety using composite polymer electrolyte (CPE) and reduced graphene oxide (rGO) Na anodes. The CPE of PVDF-HFP [poly(vinylidene fluoride-co-hexafluoropropylene)]–4% SiO2/NaClO4–TEGDME (tetraethylene glycol dimethyl ether) has high ion conductivity (1.0 mS cm−1), robust toughness, a nonflammable matrix, and strong electrolyte-locking ability. In addition, the rGO-Na anode presents fast and nondendritic Na+ plating/stripping (5.7 to 16.5 mA cm−2). The improved kinetics and safety enable the constructed rGO-Na/CPE/CO2 batteries to successfully cycle in wide CO2 partial pressure window (5 to 100%, simulated car exhaust) and especially to run for 400 cycles at 500 mA g−1 with a fixed capacity of 1000 mA·hour g−1 in pure CO2. Furthermore, we scaled up the reversible capacity to 1.1 A·hour in pouch-type batteries (20 × 20 cm, 10 g, 232 Wh kg−1). This study makes quasi–solid state Na-CO2 batteries an attractive prospect. PMID:28164158

  1. O Passeio Público do Rio de Janeiro na Literatura, na Pintura e na Fotografia do Século XIX

    Directory of Open Access Journals (Sweden)

    Solange de Aragão

    2012-06-01

    Full Text Available Este artigo tem como objetivo geral e mais amplo chamar a atenção dos pesquisadores para a importância da literatura, da pintura e da fotografia como fontes documentais para a construção da História do Paisagismo no Brasil por meio de um estudo de caso muito particular: o Passeio Público do Rio de Janeiro no século XIX. São objetivos específicos apresentar e analisar o modo como esse espaço livre público aparece na literatura, na pintura e na fotografia desse período, considerando suas transformações paisagísticas.

  2. DOKUMENTACJA SZCZEGÓŁOWA ZABYTKÓW STAROŻYTNYCH NA PRZYKŁADZIE OCENY STANU TECHNICZNEGO RZYMSKICH ZABUDOWAŃ W ALEKSANDRII

    Directory of Open Access Journals (Sweden)

    Wojciech TERLIKOWSKI

    Full Text Available Artykuł ukazuje specyfikę oraz wymagania dotyczące szczegółowej dokumentacji badań starożytnych zabytków architektonicznych będących częścią stanowisk archeologicznych. Dokładna i usystematyzowana dokumentacja jest cennym źródłem informacji dla przyszłych badaczy danej budowli. Metody przygotowania dokumentacji rozwijały się na przestrzeni lat: od metody klasycznej - ręczne sporządzania rzutów, przekrojów oraz rysunków szczegółowych, przez wykorzystanie fotogrametrii, a obecnie skaning laserowy. Zastosowanie tej ostatniej metody zostało przedstawione w poniższej pracy w oparciu o dokumentację rzymskich zabudowań w Aleksandrii. Konstrukcje te, to zespół korytarzy tworzących ortogonalną siatkę. Korytarze przekryte są sklepieniem beczkowym, które w miejscu ich krzyżowania tworzy sklepienie krzyżowe. Głównym materiałem konstrukcyjnym są ciosy wapienne. Stan zachowania konstrukcji jest zróżnicowany, niektóre fragmenty sklepień są zrujnowane, uszkodzone lub popękane. Diagnostyka tego typu konstrukcji wymaga wykonania dokładnej inwentaryzacji, do której wykorzystano skaning laserowy. W początkowej fazie prac zajęto się analizą chmury punktów uzyskanej w wyniku skanowania obiektu z kilku stanowisk. Dane poddano obróbce w celu wydzielenia niezbędnych przekrojów i rzutów konstrukcji. Uzyskane obrazy posłużyły jako baza do odwzorowania pierwotnego kształtu konstrukcji korytarzowych, a szczególnie jej najbardziej uszkodzonej części sklepienia krzyżowego. Umożliwiły one również określenie grubości konstrukcji, jak również spoczywającej na niej warstwie drobnych kamieni na zaprawie, a ostatecznie wykonanie modelu numerycznego w programie Abaqus, który będzie podstawą do dalszej analizy.

  3. Voltage dependence of Na translocation by the Na/K pump.

    Science.gov (United States)

    Nakao, M; Gadsby, D C

    During each complete reaction cycle, the Na/K pump transports three Na ions out across the cell membrane and two K ions in. The resulting net extrusion of positive charge generates outward membrane current but, until now, it was unclear how that net charge movement occurs. Reasonable possibilities included a single positive charge moving outwards during Na translocation; or a single negative charge moving inwards during K translocation; or either positive or negative charges moving during both translocation steps, but in unequal quantities. Any step that involves net charge movement through the membrane must have voltage-dependent transition rates. Here we report measurements of transient, voltage-dependent, displacement currents generated by the pump when its normal Na/K transport cycle has been interrupted by removal of external K and it is thus constrained to carry out Na/Na exchange. The quantity and voltage sensitivity of the charge moved during these transient currents suggests that Na translocation includes a voltage-dependent transition involving movement of one positive charge across the membrane. This single step can thus fully account for the electrogenic nature of Na/K exchange. The result provides important new insight into the molecular mechanism of active cation transport.

  4. Efeitos da cafeína na performance de exercícios de endurance

    Directory of Open Access Journals (Sweden)

    Giuliano Roberto da Silva

    2015-10-01

    Full Text Available Objetivo: verificar os efeitos da cafeína na performance de exercícios de endurance, através do teste de exaustão na bicicleta ergométrica. Método: participaram 50 indivíduos do sexo masculino, submetidos ao teste de exaustão em cicloergômetro após ingestão de 6mg/kg de cafeína (CAF (n=25; grupo cafeína, e 6mg/kg de placebo (PLA (n=25; grupo placebo, 40 minutos antes do teste. Os dados foram tratados estatisticamente, submetidos ao teste t de Student (p

  5. Metallic Na formation in NaCl crystals with irradiation of electron or vacuum ultraviolet photon

    Energy Technology Data Exchange (ETDEWEB)

    Owaki, Shigehiro [Osaka Prefecture Univ., Sakai, Osaka (Japan). Coll. of Integrated Arts and Sciences; Koyama, Shigeko; Takahashi, Masao; Kamada, Masao; Suzuki, Ryouichi

    1997-03-01

    Metallic Na was formed in NaCl single crystals with irradiation of a variety of radiation sources and analyzed the physical states with several methods. In the case of irradiation of 21 MeV electron pulses to the crystal blocks, the optical absorption and lifetime measurement of positron annihilation indicated appearance of Na clusters inside. Radiation effects of electron beam of 30 keV to the crystals in vacuum showed the appearance of not only metallic Na but atomic one during irradiation with Auger electron spectroscopy. Intense photon fluxes in vacuum ultraviolet region of synchrotron radiation were used as another source and an analyzing method of ultraviolet photoelectron spectroscopy. The results showed the metallic Na layered so thick that bulk plasmon can exist. (author)

  6. Summer sudden Na number density enhancements measured with the ALOMAR Weber Na Lidar

    Directory of Open Access Journals (Sweden)

    D. Heinrich

    2008-05-01

    Full Text Available We present summer Na-densities and atmospheric temperatures measured 80 to 110 km above the Arctic Lidar Observatory for Middle Atmosphere Research (ALOMAR. The Weber Na Lidar is part of ALOMAR, located at 69° N in Norway, 150 km north of the Arctic Circle. The sun does not set here during the summer months, and measurements require a narrowband Faraday Anomalous Dispersion Optical Filter (FADOF.

    We discuss an observed sudden enhancement in the Na number density around 22:00 UT on 1 to 2 June 2006. We compare this observation with previous summer measurements and find a frequent appearance of Na number density enhancements near local midnight. We describe the time of appearance, the altitude distribution, the duration and the strength of these enhancements and compare them to winter observations. We investigate possible formation mechanisms and, as others before, we find a strong link between these Na number density enhancements and sporadic E layers.

  7. Functional coupling of renal K+ and Na+ handling causes high blood pressure in Na+ replete mice.

    Science.gov (United States)

    Vitzthum, Helga; Seniuk, Anika; Schulte, Laura Helene; Müller, Maxie Luise; Hetz, Hannah; Ehmke, Heimo

    2014-03-01

    A network of kinases, including WNKs, SPAK and Sgk1, is critical for the independent regulation of K+ and Na+ transport in the distal nephron. Angiotensin II is thought to act as a key hormone in orchestrating these kinases to switch from K+ secretion during hyperkalaemia to Na+ reabsorption during intravascular volume depletion, thus keeping disturbances in electrolyte and blood pressure homeostasis at a minimum. It remains unclear, however, how K+ and Na+ transport are regulated during a high Na+ intake, which is associated with suppressed angiotensin II levels and a high distal tubular Na+ load. We therefore investigated the integrated blood pressure, renal, hormonal and gene and protein expression responses to large changes of K+ intake in Na+ replete mice. Both low and high K+ intake increased blood pressure and caused Na+ retention. Low K+ intake was accompanied by an upregulation of the sodium-chloride cotransporter (NCC) and its activating kinase SPAK, and inhibition of NCC normalized blood pressure. Renal responses were unaffected by angiotensin AT1 receptor antagonism, indicating that low K+ intake activates the distal nephron by an angiotensin-independent mode of action. High K+ intake was associated with elevated plasma aldosterone concentrations and an upregulation of the epithelial sodium channel (ENaC) and its activating kinase Sgk1. Surprisingly, high K+ intake increased blood pressure even during ENaC or mineralocorticoid receptor antagonism, suggesting the contribution of aldosterone-independent mechanisms. These findings show that in a Na+ replete state, changes in K+ intake induce specific molecular and functional adaptations in the distal nephron that cause a functional coupling of renal K+ and Na+ handling, resulting in Na+ retention and high blood pressure when K+ intake is either restricted or excessively increased.

  8. Changes in Intracellular Na+ following Enhancement of Late Na+ Current in Virtual Human Ventricular Myocytes

    Science.gov (United States)

    Giles, Wayne R.

    2016-01-01

    The slowly inactivating or late Na+ current, INa-L, can contribute to the initiation of both atrial and ventricular rhythm disturbances in the human heart. However, the cellular and molecular mechanisms that underlie these pro-arrhythmic influences are not fully understood. At present, the major working hypothesis is that the Na+ influx corresponding to INa-L significantly increases intracellular Na+, [Na+]i; and the resulting reduction in the electrochemical driving force for Na+ reduces and (may reverse) Na+/Ca2+ exchange. These changes increase intracellular Ca2+, [Ca2+]i; which may further enhance INa-L due to calmodulin-dependent phosphorylation of the Na+ channels. This paper is based on mathematical simulations using the O’Hara et al (2011) model of baseline or healthy human ventricular action potential waveforms(s) and its [Ca2+]i homeostasis mechanisms. Somewhat surprisingly, our results reveal only very small changes (≤ 1.5 mM) in [Na+]i even when INa-L is increased 5-fold and steady-state stimulation rate is approximately 2 times the normal human heart rate (i.e. 2 Hz). Previous work done using well-established models of the rabbit and human ventricular action potential in heart failure settings also reported little or no change in [Na+]i when INa-L was increased. Based on our simulations, the major short-term effect of markedly augmenting INa-L is a significant prolongation of the action potential and an associated increase in the likelihood of reactivation of the L-type Ca2+ current, ICa-L. Furthermore, this action potential prolongation does not contribute to [Na+]i increase. PMID:27875582

  9. Tecnologia simplificada na enfermagem materno infantil

    Directory of Open Access Journals (Sweden)

    Selma Campestrini

    1991-09-01

    Full Text Available A autora apresenta três modelos de tecnologia simplificada da enfermagem materno infantil: o equipamento didático SEIO COBAIA para treinar exercícios e massagens da mama e mamilo; a peça indumentária SUPRETRAUMA - sutiã preventivo de traumatismo mamilar - usado por gestantes; e, a técnica para reverter mamilo umbilicado durante o puerperio imediato. Além de corroborar na promoção do aleitamento materno e na prevenção de desmame precoce, demonstra a possibilidade da enfermagem relacionar o saber teórico-científico com o saber tecnico-prático, na saúde da mulher e da criança, com tecnologia adequada às necessidades, à compreensão e ao bem estar da população.

  10. Labirintos na cidade contemporânea

    Directory of Open Access Journals (Sweden)

    Edson Luiz André de Sousa

    Full Text Available Este artigo pretende tensionar pontos de conexão e diluição de fronteiras entre as categorias público/privado, conversando com a literatura de Baudelaire e W. Benjamin, Fredric Jamenson e Marc Augé. Através da imagem do labirinto, símbolo da cidade antiga que se quis extinguir na cidade moderna, busca-se refletir sobre alguns caminhos e caminhantes considerados excedentes na cidade contemporânea. O cenário propulsor dessa reflexão é a experiência do jornal Boca de Rua, elaborado por moradores de rua na cidade de Porto Alegre.

  11. Recent results from MoNA-LISA

    Science.gov (United States)

    Spyrou, Artemisia

    2012-03-01

    Studies of the nuclear properties of nuclei close and even beyond the limits of stability have revealed exotic modes of decay and new structural characteristics. The MoNA-LISA array is used at the National Superconducting Cyclotron Laboratory at Michigan State University to study nuclei along the neutron dripline. In a typical experiment, a radioactive beam is employed to produce the neutron-unbound state of interest. This state/resonance immediately decay into a neutron, which is detected by MoNA-LISA and a remaining charged nucleus detected by the sweeper magnet detector suite. In this talk, new exciting findings from recent MoNA-LISA experiments will be presented. These include the first observation of a dineutron decay from ^16Be, the exploration of the ``south shore'' of the Island of Inversion and the first evidence of the decay of the troubling nucleus ^26O.

  12. Rastreabilidade de componentes na cadeia de fornecimento

    OpenAIRE

    2005-01-01

    Como pouco se conhece sobre a aplicação e uso da tecnologia de RFID (Identificação por rádio frequência) na Identificação automática e recolha e dados de componentes na cadeia de fornecimento num contexto de rastreabilidade, o presente trabalho visa procurar conhecer melhor os fenómenos em estudo através de novas questões, novas explicações, tentando indagar as características e as alterações que esta tecnologia irá provocar na gestão da cadeia de fornecimento. A cadeia d...

  13. Knjige o kartografskim projekcijama na internetu

    Directory of Open Access Journals (Sweden)

    Nedjeljko Frančula

    2011-12-01

    Full Text Available U ovom prikazu skrećemo pozornost na neke knjige o kartografskim projekcijama koje su prvobitno objavljene u tisku, a potom digitalizirane i besplatno stavljene na mrežu. Neke od tih knjiga nude se na mreži kao Google e-knjige. Google godinama skuplja knjige kojima su istekla autorska prava i digitalizira ih. Fotografira se svaka stranica te zatim spaja u jednu veliku fotografiju iz koje se izvlači tekst softverom OCR. Google čuva originalnu digitalnu fotografiju u svom arhivu, a izvučeni tekst pretvara u formate HTML, PDF ili EPUB. Google danas nudi više od milijun besplatnih e-knjiga (http://www.google.com/books.

  14. UTJECAJ GMO NA EKOLOŠKU POLJOPRIVREDU

    OpenAIRE

    Fagan, John

    2008-01-01

    Gotovo svi znanstvenici se slažu da su danas uobičajene metode za ugradnju novog gena u genom biljke putem genetičkog inženjerstva (genetičke modifikacije): (1) neprecizne i slučajne, (2) pa je njihov utjecaj na biološke funkcije biljke nepredvidiv, (3) a neželjeni učinci GMO na zdravlje konzumenta i na okoliš mogući. Korištenje GMO u ekološkoj poljoprivredi je zabranjeno, stoga potrošač vjeruje da oznaka “ekološki” zakonski štiti od prisustva GMO u hrani. Međutim, povećano korištenje GMO u k...

  15. Eletrencefalograma na síndrome parkinsoniana

    Directory of Open Access Journals (Sweden)

    José Geraldo Camargo Lima

    1973-09-01

    Full Text Available Foram estudados os eletrencefalogramas de 50 pacientes parkinsonianos livres de qualquer antecedente convulsivo, sendo registrados traçados anormais em 40% dos casos. A incidência de traçados anormais foi maior na síndrome parkinsoniana bilateral do que na unilateral (52% e 25%, respectivamente. Entre as anormalidades assinaladas foram as paroxísticas as mais freqüentes (65% dos casos, caracterizando-se predominantemente por surtos de ondas teta. O registro de anormalidades paroxísticas do tipo irritativo encontrado em três casos é salientado. Alterações da atividade de base foram assinaladas em 35% dos pacientes. A idade dos pacientes não parece ter tido importante papel na gênese das anormalidades eletrencefalográficas.

  16. Recent results from NA61/SHINE

    CERN Document Server

    Kowalski, Seweryn

    2015-01-01

    The aim of the NA61/SHINE ion programme is to explore the QCD phase diagram within the range of thermodynamical variables accessible by the SPS. Moreover the experiment provides precision hadron production measurements to improve computation of neutrino fluxes in neutrino oscillation experiments and for improving air shower simulations of cosmic-ray experiments. The main physics goals of the NA61/SHINE ion programme are the study of the properties of the onset of deconfinement and the search for signatures of the critical point of strongly interacting matter. These goals are pursued by performing an energy (beam momentum 13A – 158 A GeV/c) and system size (p+p, p+Pb, Be+Be, Ar+Sc, Xe+La) scan. This paper reviews the status and results of the NA61/SHINE experiment.

  17. Na+ deposition in the fibrotic skin of systemic sclerosis patients detected by 23Na-magnetic resonance imaging.

    Science.gov (United States)

    Kopp, Christoph; Beyer, Christian; Linz, Peter; Dahlmann, Anke; Hammon, Matthias; Jantsch, Jonathan; Neubert, Patrick; Rosenhauer, Daniela; Müller, Dominik N; Cavallaro, Alexander; Eckardt, Kai-Uwe; Schett, Georg; Luft, Friedrich C; Uder, Michael; Distler, Jörg H W; Titze, Jens

    2017-04-01

    Skin fibrosis is the predominant feature of SSc and arises from excessive extracellular matrix deposition. Glycosaminoglycans are macromolecules of the extracellular matrix, which facilitate Na + accumulation in the skin. We used 23 Na-MRI to quantify Na + in skin. We hypothesized that skin Na + might accumulate in SSc and might be a biomarker for skin fibrosis. In this observational case-control study, skin Na + was determined by 23 Na-MRI using a Na + volume coil in 12 patients with diffuse cutaneous SSc and in 21 control subjects. We assessed skin fibrosis by the modified Rodnan skin score prior to 23 Na-MRI and on follow-up 12 months later. 23 Na-MRI demonstrated increased Na + in the fibrotic skin of SSc patients compared with skin from controls [mean ( s . d .): 27.2 (5.6) vs 21.4 (5.3) mmol/l, P skin [26.2 (4.8) vs 19.2 (3.4) mmol/l, P skin Na + amount was correlated with changes in follow-up modified Rodnan skin score (R 2 = 0.68). 23 Na-MRI detected increased Na + in the fibrotic SSc skin; high Na + content was associated with progressive skin disease. Our findings provide the first evidence that 23 Na-MRI might be a promising tool to assess skin Na + and thereby predict progression of skin fibrosis in SSc.

  18. Diffusion of propylene adsorbed in Na-Y and Na-ZSM5 zeolites: Neutron scattering and FTIR studies

    Indian Academy of Sciences (India)

    S Gautam; A K Tripathi; V S Kamble; S Mitra; R Mukhopadhyay

    2008-11-01

    Here we report the quasielastic neutron scattering and FTIR studies on the dynamics of propylene adsorbed in Na-Y and Na-ZSM5 zeolites. QENS data show that although the mechanism of translational motion of propylene is jump diffusion in both the cases of Na-Y and Na-ZSM5 zeolites, the diffusivity is affected by the host size and is hindered in the case of Na-ZSM5. FTIR studies showed that guest–host interaction in Na-ZSM5 is stronger than that in Na-Y zeolite corroborating the QENS results.

  19. Concentration dependence of Li+/Na+ diffusion in manganese hexacyanoferrates

    Science.gov (United States)

    Takachi, Masamitsu; Fukuzumi, Yuya; Moritomo, Yutaka

    2016-06-01

    Manganese hexacyanoferrates (Mn-HCFs) with a jungle-gym-type structure are promising cathode materials for Li+/Na+ secondary batteries (LIBs/SIBs). Here, we investigated the diffusion constants D Li/D Na of Li+/Na+ against the Li+/Na+ concentration x Na/x Li and temperature (T) of A 1.32Mn[Fe(CN)6]0.833.6H2O (A = Li and Na). We evaluated the activation energy E\\text{a}\\text{Li}/E\\text{a}\\text{Na} of D Li/D Na against x Na/x Li. We found that E\\text{a}\\text{Na} steeply increases with x Na from 0.41 eV at x Na = 0.69 to 0.7 eV at 1.1. The increase in E\\text{a}\\text{Na} is ascribed to the occupancy effect of the Na+ site. The increase in E\\text{a}\\text{Li} is suppressed, probably because the number of Li+ sites is three times that of Na+ sites.

  20. UPORABA TEHNOLOGIJE VOIP NA MOBILNIH NAPRAVAH SYMBIAN

    OpenAIRE

    Uršič, Tine

    2013-01-01

    V sklopu diplomskega dela smo razvili aplikacijo, katere cilj je nižanje stroškov klicev s pomočjo tehnologije VoIP. Ta za komunikacijo uporablja protokol IP in zaobide potrebo po navadnih in dražjih GSM klicih. V času načrtovanja aplikacije je bilo okolje Symbian najbolj razširjena mobilna platforma za dovolj zmogljive, t.i. »pametne telefone«, ki lahko poganjajo VoIP aplikacije. Izbrali smo skupek knjižnic, poimenovanih Qt, ki omogočajo enostavno prenosljivost na druge platforme. Podr...

  1. Recent results and prospects from NA62

    Directory of Open Access Journals (Sweden)

    Bizzeti Andrea

    2016-01-01

    K+ → π+ vv̄ is a theoretically very clean decay where indirect effects of new physics may be detectable. The NA62 apparatus has been significantly upgraded between 2008 and 2014 in order to measure the branching ratio of this decay with 10% precision. The NA62 experiment took data with the new setup in pilot runs in 2014 and 2015, reaching the design beam intensity. Results of first data quality studies in view of the 2016-2017 physics runs are presented.

  2. ARTE E TRANSGRESSÃO NA MODERNIDADE

    OpenAIRE

    Cascelli Farinasso, Gabriela

    2014-01-01

    O presente artigo busca explorar a arte como ferramenta para mudanças sociais na modernidade relacionando-a com os conceitos apresentados por Nicolas Bourriaud em seu livro Estética Relacional. A Street Art é apresentada como recorte dentre os movimentos artísticos, ressaltando-se sua importância e suas características do ponto de vista espacial e temporal e na criação de “lugares de pausa” no meio urbano, que levam o observador a refletir sobre a obra e o desviam do seu percurso. A transgres...

  3. Abordagem neurologica na sindrome do X fragil

    OpenAIRE

    Marilisa Mantovani Guerreiro

    1993-01-01

    Resumo: Com o propósito de realizar a abordagem neurológica na Síndrome do X Frágil (SXF), estudaram-se 11 pacientes com este diagnóstico citogenético. A idade variou de 8 a 19 anos. Nove pacientes eram do sexo masculino e dois do feminino. Todos os indivíduos apresentaram pavilhões auriculares grandes e faces alongadas. Observou-se fronte proeminente em 63% dos casos e macrorquidia em 33% dentre aqueles do sexo masculino. Atraso na aquisição da fala, fala repetitiva, perseverativa, impulsiva...

  4. O problema do conhecimento verdadeiro na epidemiologia

    Directory of Open Access Journals (Sweden)

    Ayres José Ricardo de Carvalho Mesquita

    1992-01-01

    Full Text Available São examinadas as bases filosóficas da validação do conhecimento científico, com o intuito de estabelecer uma visão crítica a respeito da adoção das proposições de Popper na epidemiologia. Ressalta-se o caráter conservador que resulta das limitações técnicas implicadas na sua adoção, não obstante o evidente aumento da racionalidade e da criatividade heurística que propicia.

  5. Status for 2017, CERN NA63

    CERN Document Server

    Uggerhoej, UI

    2017-01-01

    In the NA63 experiment of May-June 2017 the purpose was to look for the effect of classical radiation reaction as described in \\cite{DiPiazza20171} but for 50 GeV positrons aligned to the (110) plane of silicon crystals of varying thicknesses in the range 1-6 mm. The data which was taken during the run shows promising results, but the final verdict awaits accurate calculations of the theoretically expected spectra, and a final analysis. For the 2016 results on quantum radiation reaction obtained by CERN NA63, we have submitted a manuscript, which is presently under refereeing \\cite{Wist17}.

  6. Dificuldades de aprendizagem na leitura e na escrita: o contributo de jogos eletrónicos na motivação e na aprendizagem

    OpenAIRE

    Nogueira, Joana Maria Duarte

    2015-01-01

    Projeto de Intervenção apresentado à Escola Superior de Educação de Lisboa para obtenção do grau de Mestre em Educação Especial, Especialização em Problemas de Aprendizagem e Comportamento A dislexia carateriza-se por habilidades alteradas dos processos de leitura (fluência, compreensão e leitura correta de palavras). Além destas pode envolver ainda dificuldades no reconhecimento de palavras escritas, na descodificação, na adequação e habilidades ortográficas, podendo ainda manifestar-se n...

  7. Qualidade de vida sexual na menopausa

    OpenAIRE

    2011-01-01

    A Qualidade de Vida Sexual é um termo habitualmente usado, para abranger aspectos relacionados com a ausência ou presença de problemas sexuais, satisfação e bem-estar sexual, sendo esta bastante subjectiva. Neste sentido, é fundamental rememorar que a presença de problemas sexuais não é, de todo sinónimo de má qualidade de vida sexual. Na verdade, a sexualidade na menopausa inclui, igualmente, sexo, relaxamento, comunicação e intimidade partilhada entre o casal, como em qualquer outra etapa d...

  8. Wpływ procesów odlewniczych na poziom stężenia pyłów respirabilnych na stanowiskach pracy w odlewni żeliwa

    Directory of Open Access Journals (Sweden)

    K. Kowalski

    2012-12-01

    Full Text Available Jednym z głównych zagrożeń powstających w środowisku pracy w trakcie produkcji odlewów żeliwnych są pyły przemysłowea w szczególności pyły frakcji respirabilnej (pęcherzykowej. Pył całkowity to zbiór wszystkich cząstek otoczonych powietrzemw określonej objętości. Za frakcję respirabilną pyłu uważa się zbiór cząstek przechodzących przez selektor wstępny (metoda filtracyjnowagowao średniej wartości średnicy aerodynamicznej 3.5 0.3 m z odchyleniem standardowym 1.5 0.1 m. Pyły respirabilneprzyczyniają się w znaczącym stopniu do chorób płucnych a w szczególności pylicy płuc W warunkach procesów odlewniczych cząstkipyłu respirabilnego zawierają także inne szkodliwe substancje między innymi metale i ich związki. Pomiary narażenia zawodowego napyły na stanowiskach pracy w zakładach odlewniczych żeliwa wskazują, że szczególnie wysokie stężenia pyłów respirabilnych występująna stanowiskach pracy wybijacza odlewów, formierza, wytapiacza i wykańczacza odlewów.W kwietniu 2009 roku uruchomiono w Zakładzie Metalurgicznym ALSTOM Power w Elblągu produkcję wielkogabarytowych (do 60ton odlewów z żeliwa sferoidalnego. Już na etapie wstępnej oceny ryzyka, na podstawie danych literaturowych założono, że jednym zeznaczących zagrożeń na stanowiskach formowania odlewów będzie pył przemysłowy. Pomiary zapylenia wykonane na tych stanowiskachw latach 2009 – 2011 potwierdziły oceny wstępne. Pomimo nowoczesnej instalacji odpylania pieców indukcyjnych wyposażonej w ujęciepyłów znad tygla (system Tornado oraz ogólnej, wymuszonej wentylacji hali (wentylatory dachowe, w przypadku większości pomiarów stanowiskowych przeprowadzonych metodą dozymetrii indywidualnej stwierdzono przekroczenia NDS pyłu respirabilnego w odniesieniu do 8- godzinnego czasu pracy. W trakcie tych samych badań zauważono, że przekroczenia NDS pyłu całkowitego wystąpiły tylko w przypadku 2 pomiarów na

  9. Probing luminescence centers in Na rich feldspar

    DEFF Research Database (Denmark)

    Prasad, Amit Kumar; Lapp, Torben; Kook, Myung Ho;

    2016-01-01

    our understanding of the luminescence mechanisms and recombination sites, in a sample of Na rich plagioclase feldspar (oligoclase). Both the UV and violet–blue emissions show resonant excitations arising from a distribution of energy levels. We propose, contrary to the general understanding...

  10. Trapping of radioactive {sup 21}Na

    Energy Technology Data Exchange (ETDEWEB)

    Kruithof, Wilbert L.; Hoek, Duurt J. van der; Giri, Gouri S.; Hoekstra, Ronnie; Hoekstra, Steven; Jungmann, Klaus; Onderwater, Gerco; Santra, Bodhaditya; Shildling, Praveen D.; Sohani, Moslem; Versolato, Oscar O.; Willmann, Lorenz; Wilschut, Hans W. [Kernfysisch Versneller Instituut, University Groningen (Netherlands)

    2010-07-01

    Radioactive {sup 21}Na atoms in a magneto-optical trap (MOT) provide an excellent opportunity to search for non-Standard Model contributions in the weak interactions. In particular, correlations between the {beta}-particle and the neutrino are sensitive to time reversal symmetry violating effects. The Na isotope is produced at the TRI{mu}P facility of the KVI using intense {sup 20}Ne beams from the AGOR cyclotron on a cooled deuterium target. The isotopes are stopped and re-thermalized in a Thermal Ionizer. They are transported as a low energy ion beam to a MOT cell where they are neutralized and subsequently captured by laser light. The trapped Na atoms will be transferred to a second MOT which is placed inside a reaction microscope to measure the momentum distribution of the recoiling daughter nuclei after the {beta}-decay. The {beta}-particle will be detected in a scintillation detector. These two devices have been characterized. A pulsed UV laser was used to ionize trapped Na atoms in order to simulate the {beta}-decay in the reaction microscope. The momentum distribution of the recoil ions is measured. The setup of the whole experiment will be presented.

  11. Pijn tijdens of na de wortelkanaalbehandeling

    NARCIS (Netherlands)

    Wesselink, P.R.

    2012-01-01

    Een wortelkanaalbehandeling kan pijn veroorzaken tijdens en/of na de behandeling. Tijdens de behandeling moet dan onderscheid worden gemaakt tussen pijn bij een pulpitis en pijn bij een necrotische pulpa. In beide gevallen kan die pijn effectief worden bestreden, afhankelijk van de toestand waarin h

  12. NA48: Wiring up for Change

    CERN Multimedia

    2001-01-01

    The NA48 Collaboration is rebuilding its drift chambers ready for the experiment to start up again this coming July. An intricate task involving the soldering of over 24,000 wires! The future of the NA48 experiment is coming right down to the wire, that is, the wires which the Collaboration is installing in the clean room of Hall 887 on the Prévessin site. Six days a week, technicians are working in shifts to rebuild the experiment's drift chambers. The original chambers were damaged when a section of a vacuum tube imploded at the end of 1999. A year ago, CERN gave the green light for this essential part of the spectrometer to be rebuilt, so the NA48 experiment, which studies CP violation (see box), still has a bright future ahead of it. Three years of data-taking ahead The NA48 experiment aims to penetrate the secrets of CP (Charge Parity) violation. Charge and parity are two parameters which distinguish a particle from an antiparticle. In other words, an electron possesses a negative electric ...

  13. Habitus professoral na sala de aula virtual

    Directory of Open Access Journals (Sweden)

    Alexandre Marinho Pimenta

    2014-09-01

    Full Text Available Entendendo que a indiferença na ação pedagógica contribui para a reprodução das desigualdades no sistema de ensino, o presente artigo busca captar, a partir de entrevistas semiestruturadas, traços do habitus de professores supervisores de disciplinas do curso de Licenciatura em Pedagogia na modalidade a distância na Universidade de Brasília - UnB no âmbito do Sistema Universidade Aberta do Brasil - UAB. As orientações metodológicas de Bourdieu (2007 foram um dos elementos orientadores na análise das entrevistas, considerando ainda o uso heurístico do conceito de habitus. Conclui-se que o habitus professoral envolve esforços voluntários em busca de uma ação pedagógica diferenciada. No entanto, ele é ambíguo e condescendente frente aos limites do modelo de EaD no âmbito da UAB. Ao fim, os dados analisados permitem fornecer elementos para reorientação político-pedagógica que vise a um novo modelo de EaD nacional.

  14. Electronic Polarisability of NaNO2-NaNO3 and NaOH-NaNO3 Ionic Melts and Effective Ionic Radius of OH-

    Science.gov (United States)

    Iwadate, Yasuhiko; Ohnishi, Ryosuke; Ohkubo, Takahiro

    2017-01-01

    Molar volumes and refractive indexes of molten NaNO2-NaNO3 and NaOH-NaNO3 systems were measured by dilatometry and goniometry, respectively. The molar volumes of both systems increased with increasing temperature. Refractive indexes decreased with a rise of temperature or with increasing wavelength of the incident visible light. Assuming that the electronic polarisability is inherent in an ion, the electronic polarisability of a OH- ion in the melt was estimated from the Lorentz-Lorenz equation to be 1.26×10-30 m3, being comparable with that in the crystal. The effective ionic radius of a OH- ion was evaluated from the obtained electronic polarisability to be 1.34×10-10 m, using the correlation between the third power of the ionic radius and the electronic polarisability of an ion so far reported. The effective ionic radius obtained in this work was in good agreement with that assigned by Shannon.

  15. NA49: lead-lead collision

    CERN Multimedia

    1996-01-01

    This is an image of an actual lead ion collision taken from tracking detectors on the NA49 experiment, part of the heavy ion project at CERN. These collisions produce a very complicated array of hadrons as the heavy ions break up. It is hoped that one of these collisions will eventually create a new state of matter known as quark-gluon plasma.

  16. Categoria de gênero na enfermagem

    Directory of Open Access Journals (Sweden)

    Alcione Leite da Silva

    1999-03-01

    Full Text Available Este estudo teve por objetivo analisar as categorias de gênero, a partir de periódicos sobre estudo de gênero na enfermagem brasileira. Usando uma abordagem exploratória, analisamos os artigos na área, publicados em dez periódicos nacionais de enfermagem, no período de 1955 a 1997/1. Com base na análise dos discursos, as categorias centrais para as quais convergiram as atenções das/os autoras/es foram: gênero e determinantes históricos e sociais no desenvolvimento da profissão de enfermagem, gênero e trabalho, gênero e saúde, gênero e educação e gênero e feminismo. Outras perspectivas importantes, menos enfatizadas, mas emergentes na literatura de enfermagem foram: gênero e cuidado, gênero e família, gênero e violência.

  17. Concentratie gewasbeschermingsmiddelen na verhitting dompelbad bloembollen

    NARCIS (Netherlands)

    Bulle, A.A.E.; Lans, van der A.M.; Aanholt, van J.T.M.

    2014-01-01

    De meest gebruikte methode van ontsmetting van bloembollen en –knollen is een dompeling in een mix van fungiciden. In het proces van bolontsmetting worden partijen bollen na elkaar ontsmet in hetzelfde dompelbad. Met een partij bollen kan een dompelbad behoorlijk vervuild raken met bijvoorbeeld (ste

  18. Pijn tijdens of na de wortelkanaalbehandeling

    NARCIS (Netherlands)

    Wesselink, P.R.

    2012-01-01

    Een wortelkanaalbehandeling kan pijn veroorzaken tijdens en/of na de behandeling. Tijdens de behandeling moet dan onderscheid worden gemaakt tussen pijn bij een pulpitis en pijn bij een necrotische pulpa. In beide gevallen kan die pijn effectief worden bestreden, afhankelijk van de toestand waarin

  19. Recent results and prospects from NA62

    Science.gov (United States)

    Bizzeti, Andrea

    2016-11-01

    A large sample of charged kaon decays in 2007 has been collected by the NA62 experiment at CERN SPS using the experimental setup of the former NA48 experiment. Its intense kaon beam provides an abundant source of tagged neutral pions in vacuum. A measurement of the electromagnetic transition form factor slope of the neutral pion from 1:05 × 106 fully reconstructed π0 Dalitz decays is presented. The obtained preliminary value a = (3.70 ± 0.53stat ± 0.36syst) × 10-2 is the first 5.8σ observation of a non-zero slope in the time-like region of momentum transfer. K+ → π+ vv¯ is a theoretically very clean decay where indirect effects of new physics may be detectable. The NA62 apparatus has been significantly upgraded between 2008 and 2014 in order to measure the branching ratio of this decay with 10% precision. The NA62 experiment took data with the new setup in pilot runs in 2014 and 2015, reaching the design beam intensity. Results of first data quality studies in view of the 2016-2017 physics runs are presented.

  20. Water transport by the renal Na(+)-dicarboxylate cotransporter

    DEFF Research Database (Denmark)

    Meinild, A K; Loo, D D; Pajor, A M;

    2000-01-01

    This study investigated the ability of the renal Na(+)-dicarboxylate cotransporter, NaDC-1, to transport water. Rabbit NaDC-1 was expressed in Xenopus laevis oocytes, cotransporter activity was measured as the inward current generated by substrate (citrate or succinate), and water transport...... was monitored by the changes in oocyte volume. In the absence of substrates, oocytes expressing NaDC-1 showed an increase in osmotic water permeability, which was directly correlated with the expression level of NaDC-1. When NaDC-1 was transporting substrates, there was a concomitant increase in oocyte volume....... This solute-coupled influx of water took place in the absence of, and even against, osmotic gradients. There was a strict stoichiometric relationship between Na(+), substrate, and water transport of 3 Na(+), 1 dicarboxylate, and 176 water molecules/transport cycle. These results indicate that the renal Na...

  1. Water transport by the renal Na(+)-dicarboxylate cotransporter

    DEFF Research Database (Denmark)

    Meinild, A K; Loo, D D; Pajor, A M

    2000-01-01

    was monitored by the changes in oocyte volume. In the absence of substrates, oocytes expressing NaDC-1 showed an increase in osmotic water permeability, which was directly correlated with the expression level of NaDC-1. When NaDC-1 was transporting substrates, there was a concomitant increase in oocyte volume....... This solute-coupled influx of water took place in the absence of, and even against, osmotic gradients. There was a strict stoichiometric relationship between Na(+), substrate, and water transport of 3 Na(+), 1 dicarboxylate, and 176 water molecules/transport cycle. These results indicate that the renal Na......This study investigated the ability of the renal Na(+)-dicarboxylate cotransporter, NaDC-1, to transport water. Rabbit NaDC-1 was expressed in Xenopus laevis oocytes, cotransporter activity was measured as the inward current generated by substrate (citrate or succinate), and water transport...

  2. Presoja notranjih kontrol pri obračunu davka na dodano vrednost na primeru "Podjetja x"

    OpenAIRE

    Majcen, Borut

    2016-01-01

    Poslovanje podjetja si je ob odsotnosti notranjih kontrol nemogoče predstavljati. Podjetja so podvržena raznim tveganjem, še posebej v današnjih razmerah globalnega poslovanja, ko se podjetja soočajo z vedno novimi izzivi, kar prinaša tudi nova tveganja. Najučinkovitejši ukrep za obvladovanje tveganj predstavlja vzpostavitev sistema notranjih kontrol. Obvladovanje tveganj pa ne poteka samo na ravni podjetja kot celote, ampak je prisotno na vseh področjih delovanja podjetja, torej tudi na p...

  3. Biossegurança na odontologia

    Directory of Open Access Journals (Sweden)

    André Luiz Dantas Bezerra

    2014-04-01

    Full Text Available Introdução: As atividades laborais, de modo geral, expõem os trabalhadores a riscos ocupacionais dos mais variados. Esses riscos incluem agentes físicos, químicos, ergonômicos, de acidentes e biológicos. O contato rotineiro com esses últimos deve ser motivo de reflexão e intervenção. Objetivo: Descrever os aspectos da biossegurança na odontologia. Métodos: Foi realizada uma revisão do estado da arte, adotando-se critérios para análise dos trabalhos mais diretamente relacionados à prática odontológica. A partir dos descritores controlados (DeCS "biossegurança" e "odontologia", procederam-se a busca na Literatura Latino-Americana e do Caribe em Ciências da Saúde, na Scientific Electronic Library Online, na National Library of Medicine e na Biblioteca Cochrane. Resultados: Com a associação entre os DeCS, chegou-se a 66 artigos, porém, após refinamento foram incluídos nesta revisão 12 artigos. Nos resultados foi evidenciado que a produção científica sobre biossegurança é vasta, bem como é ampla na odontologia, contudo, quando da concentração de trabalhos contempladores da associação dos termos biossegurança e odontologia, a quantidade de estudos diminui consideravelmente. Não obstante, as pesquisas foram, em sua maioria, desenvolvidas por estudiosos nacionais, da região nordeste e evidenciaram que o conhecimento e a adoção de medidas de segurança biológica na área ainda são insuficientes para garantir a proteção da equipe e dos pacientes qualitativamente. Conclusão: Sugere-se que as normas de precaução padrão sejam seguidas rigidamente e que ações de educação sejam promovidas entre os profissionais.

  4. Effects of non-uniform root zone salinity on water use, Na+ recirculation, and Na+ and H+ flux in cotton.

    Science.gov (United States)

    Kong, Xiangqiang; Luo, Zhen; Dong, Hezhong; Eneji, A Egrinya; Li, Weijiang

    2012-03-01

    A new split-root system was established through grafting to study cotton response to non-uniform salinity. Each root half was treated with either uniform (100/100 mM) or non-uniform NaCl concentrations (0/200 and 50/150 mM). In contrast to uniform control, non-uniform salinity treatment improved plant growth and water use, with more water absorbed from the non- and low salinity side. Non-uniform treatments decreased Na(+) concentrations in leaves. The [Na(+)] in the '0' side roots of the 0/200 treatment was significantly higher than that in either side of the 0/0 control, but greatly decreased when the '0' side phloem was girdled, suggesting that the increased [Na(+)] in the '0' side roots was possibly due to transportation of foliar Na(+) to roots through phloem. Plants under non-uniform salinity extruded more Na(+) from the root than those under uniform salinity. Root Na(+) efflux in the low salinity side was greatly enhanced by the higher salinity side. NaCl-induced Na(+) efflux and H(+) influx were inhibited by amiloride and sodium orthovanadate, suggesting that root Na(+) extrusion was probably due to active Na(+)/H(+) antiport across the plasma membrane. Improved plant growth under non-uniform salinity was thus attributed to increased water use, reduced leaf Na(+) concentration, transport of excessive foliar Na(+) to the low salinity side, and enhanced Na(+) efflux from the low salinity root.

  5. Synthesis of Na-A and/or Na-X zeolite/porous carbon composites from carbonized rice husk

    Science.gov (United States)

    Katsuki, Hiroaki; Komarneni, Sridhar

    2009-07-01

    Na-A and/or Na-X zeolite/porous carbon composites were prepared under hydrothermal conditions by NaOH dissolution of silica first from carbonized rice husk followed by addition of NaAlO 2 and in situ crystallization of zeolites i.e., using a two-step process. When a one-step process was used, both Na-A and Na-X zeolites crystallized on the surface of carbon. Na-A or Na-X zeolite crystals were prepared on the porous carbonized rice husk at 90 °C for 2-6 h by changing the SiO 2/Al 2O 3, H 2O/Na 2O and Na 2O/SiO 2 molar ratios of precursors in the two-step process. The surface area and NH 4+-cation exchange capacity (CEC) of Na-A zeolite/porous carbon were found to be 171 m 2/g and 506 meq/100 g, respectively, while those of Na-X zeolite/porous carbon composites were 676 m 2/g and 317 meq/100 g, respectively. Na-A and Na-X zeolites are well-known microporous and hydrophilic materials while carbonized rice husk was found to be mesoporous (pores of ˜3.9 nm) and hydrophobic. These hybrid microporous-mesoporous and hydrophilic-hydrophobic composites are expected to be useful for decontamination of metal cations as well as organic contaminants simultaneously.

  6. Phase Equilibria of Quaternary SystemNaCl-NaBr-Na2B4O7-H2O at 348 K

    Institute of Scientific and Technical Information of China (English)

    LI Ting; SANG Shi-hua; CUI Rui-zhi; ZHANG Kai-jie

    2013-01-01

    The phase equilibria of quatemary system NaC1-NaBr-Na2B4O7-H2O at 348 K were studied by the isothermal equilibrium method.The solubilities and densities of the equilibrium solution were determined.According to the experimental data,the phase diagram,density-composition diagrams and water content diagram of the quaternary system at 348 K were plotted respectively.And the phase diagram consists of one univariant curve,two crystallization fields and without any invariant point of the quaternary system.The equilibrium solid phases of the two crystallization fields were Na(C1,Br) and Na2B4O7·SH2O.The experimental results show that the quaternary system contained solid solution.The densities of the solution decrease with increasing NaC1 concentration and increase with increasing NaBr concentration.

  7. Asphericity in the Fermi Surface and Fermi Energy of Na-K, Na-Rb and Na-Cs Binary Alloys

    Institute of Scientific and Technical Information of China (English)

    Minal H. Patel; A.M. Vora; P.N. Gajjar; A.R. Jani

    2002-01-01

    Detailed theoretical investigations into asphericity in the Fermi surface (FS) and Fermi energy (FE) ofNa1_xKx, Na1_xRbx, and Na1_xCsx binary solid solutions are carried out for the first time. The alloying behavior ofthe K, Rb, and Cs with the Na generates the Fermi surface distortion (FSD) of bce simple metals. The FS of Na-K,Na-Rb, and Na-Cs solid solution is a distorted sphere with the largest deviation along [110]. We have found that theimpact of local-field correction function on FSD is maximun at [100] point and minimum at [111] point. The exchangeand correlation effect is found to suppress the value of FE.

  8. $^{24}$Mg($p$, $\\alpha$)$^{21}$Na reaction study for spectroscopy of $^{21}$Na

    CERN Document Server

    Cha, S M; Kim, A; Lee, E J; Ahn, S; Bardayan, D W; Chipps, K A; Cizewski, J A; Howard, M E; Manning, B; O'Malley, P D; Ratkiewicz, A; Strauss, S; Kozub, R L; Matos, M; Pain, S D; Pittman, S T; Smith, M S; Peters, W A

    2015-01-01

    The $^{24}$Mg($p$, $\\alpha$)$^{21}$Na reaction was measured at the Holifield Radioactive Ion Beam Facility at Oak Ridge National Laboratory in order to better constrain spins and parities of energy levels in $^{21}$Na for the astrophysically important $^{17}$F($\\alpha, p$)$^{20}$Ne reaction rate calculation. 31 MeV proton beams from the 25-MV tandem accelerator and enriched $^{24}$Mg solid targets were used. Recoiling $^{4}$He particles from the $^{24}$Mg($p$, $\\alpha$)$^{21}$Na reaction were detected by a highly segmented silicon detector array which measured the yields of $^{4}$He particles over a range of angles simultaneously. A new level at 6661 $\\pm$ 5 keV was observed in the present work. The extracted angular distributions for the first four levels of $^{21}$Na and Distorted Wave Born Approximation (DWBA) calculations were compared to verify and extract angular momentum transfer.

  9. Decision Trees in the Analysis of the Intensity of Damage to Portal Frame Buildings in Mining Areas / Drzewa Decyzyjne W Analizie Intensywności Uszkodzeń Budynków Halowych Na Terenach Górniczych

    Science.gov (United States)

    Firek, Karol; Rusek, Janusz; Wodyński, Aleksander

    2015-09-01

    The article presents a preliminary database analysis regarding the technical condition of 94 portal frame buildings located in the mining area of Legnica-Głogów Copper District (LGOM), using the methodology of decision trees. The scope of the analysis was divided into two stages. The first one included creating a decision tree by a standard CART method, and determining the importance of individual damage indices in the values of the technical wear of buildings. The second one was based on verification of the created decision tree and the importance of these indices in the technical wear of buildings by means of a simulation of individual dendritic models using the method of random forest. The obtained results confirmed the usefulness of decision trees in the early stage of data analysis. This methodology allows to build the initial model to describe the interaction between variables and to infer about the importance of individual input variables. Celem prezentowanych w artykule badań było sprawdzenie możliwości pozyskiwania informacji na temat udziału uszkodzeń w zużyciu technicznym zabudowy terenu górniczego z wykorzystaniem metody drzew decyzyjnych. Badania przeprowadzono na podstawie utworzonej przez autorów bazy danych o stanie technicznym i uszkodzeniach 94 budynków typu halowego, usytuowanych na terenie górniczym Legnicko-Głogowskiego Okręgu Miedziowego (LGOM). Do analiz przyjęto metodę drzew decyzyjnych CART - Classification & Regression Tree, na bazie której utworzono model aproksymujący wartość zużycia technicznego budynków. W efekcie ustalono wpływ poszczególnych zmiennych na przebieg modelowanego procesu (Rys. 3 i 4). W drugim etapie, stosując metodę losowych lasów przeprowadzono weryfikację wyników uzyskanych dla modelu utworzonego metodą CART (Tab. 2). Przeprowadzone badania pozwoliły na ustalenie udziałów wyspecyfikowanych kategorii uszkodzeń elementów badanych budynków w ich stopniu zużycia technicznego. Najwi

  10. Regulation of cardiac myocyte contractility by phospholemman: Na+/Ca2+ exchange versus Na+ -K+ -ATPase.

    Science.gov (United States)

    Song, Jianliang; Zhang, Xue-Qian; Wang, JuFang; Cheskis, Ellina; Chan, Tung O; Feldman, Arthur M; Tucker, Amy L; Cheung, Joseph Y

    2008-10-01

    Phospholemman (PLM) regulates cardiac Na(+)/Ca(2+) exchanger (NCX1) and Na(+)-K(+)-ATPase in cardiac myocytes. PLM, when phosphorylated at Ser(68), disinhibits Na(+)-K(+)-ATPase but inhibits NCX1. PLM regulates cardiac contractility by modulating Na(+)-K(+)-ATPase and/or NCX1. In this study, we first demonstrated that adult mouse cardiac myocytes cultured for 48 h had normal surface membrane areas, t-tubules, and NCX1 and sarco(endo)plasmic reticulum Ca(2+)-ATPase levels, and retained near normal contractility, but alpha(1)-subunit of Na(+)-K(+)-ATPase was slightly decreased. Differences in contractility between myocytes isolated from wild-type (WT) and PLM knockout (KO) hearts were preserved after 48 h of culture. Infection with adenovirus expressing green fluorescent protein (GFP) did not affect contractility at 48 h. When WT PLM was overexpressed in PLM KO myocytes, contractility and cytosolic Ca(2+) concentration ([Ca(2+)](i)) transients reverted back to those observed in cultured WT myocytes. Both Na(+)-K(+)-ATPase current (I(pump)) and Na(+)/Ca(2+) exchange current (I(NaCa)) in PLM KO myocytes rescued with WT PLM were depressed compared with PLM KO myocytes. Overexpressing the PLMS68E mutant (phosphomimetic) in PLM KO myocytes resulted in the suppression of I(NaCa) but had no effect on I(pump). Contractility, [Ca(2+)](i) transient amplitudes, and sarcoplasmic reticulum Ca(2+) contents in PLM KO myocytes overexpressing the PLMS68E mutant were depressed compared with PLM KO myocytes overexpressing GFP. Overexpressing the PLMS68A mutant (mimicking unphosphorylated PLM) in PLM KO myocytes had no effect on I(NaCa) but decreased I(pump). Contractility, [Ca(2+)](i) transient amplitudes, and sarcoplasmic reticulum Ca(2+) contents in PLM KO myocytes overexpressing the S68A mutant were similar to PLM KO myocytes overexpressing GFP. We conclude that at the single-myocyte level, PLM affects cardiac contractility and [Ca(2+)](i) homeostasis primarily by its direct

  11. Hidroginástica na terceira idade

    Directory of Open Access Journals (Sweden)

    Karla Campos de Paula

    1998-02-01

    Full Text Available O processo de envelhecimento no indivíduo saudável está relacionado com inúmeras alterações psicológicas e físicas que interferem na área motora, concorrendo para a inatividade e contribuindo para o aparecimento e agravamento de determinadas doenças, além de influenciar negativamente a realização das atividades de vida diária. Portanto, a prática de atividade física é fundamental para o idoso, não só na prevenção de doenças como na reabilitação de suas habilidades motoras, promovendo um estilo de vida saudável que é fator preponderante para a melhoria da qualidade de vida. Contudo, algumas precauções devem ser adotadas na prescrição da atividade direcionada para o idoso, a fim de que esta seja segura e prazerosa. Dentre os exercícios mais adequados aos idosos estão a caminhada, o ciclismo, a natação e a hidroginástica. Devido a sua grande procura, a hidroginástica vem aumentando o número de adeptos na terceira idade. Ela propicia ao idoso o aumento de sua capacidade aeróbia, força muscular, flexibilidade articular e o treinamento de habilidades específicas como equilíbrio e coordenação motora. Soma-se ainda o fato de esta atividade oferecer ambiente de relaxamento e incentivo ao contato social, atuando no combate ao estresse, depressão, na melhoria da autopercepção corporal e da auto-estima. Devemos, então, estar atentos às particularidades da hidroginástica, a fim de aproveitar todas as vantagens que esta oferece para o programa de exercícios direcionado para a terceira idade.

  12. Transport of Na48 Drift Chambers to Dubna

    CERN Multimedia

    GOLOVATYUK, V

    2010-01-01

    On 22 July, in the occasion of the departure of the Na48 Drift Chambers from CERN, Mikhail Itkis (acting Director of the JIINR) and Rolf Heuer (CERN Director General) visited the NA62 experimental area.

  13. Mechanisms and regulation of Na(+) uptake by freshwater fish.

    Science.gov (United States)

    Kumai, Yusuke; Perry, Steve F

    2012-12-01

    Mechanisms of ion uptake by freshwater (FW) fish have received considerable attention over the past 80 years. Through an assortment of techniques incorporating whole animal physiology, electrophysiology and molecular biological approaches, three models have been proposed to account for Na(+) uptake. (1) Direct exchange of Na(+) and H(+) via one or more types of Na(+)/H(+) exchanger (slc9), (2) uptake of Na(+) through epithelial Na(+) channels energized by an electrical gradient created by H(+)-ATPase and (3) Na(+)/Cl(-) co-transport (slc12). While each mechanism is supported at least in part by theoretical or experimental data, there are several outstanding questions that have not yet been fully resolved. Furthermore, there are few details concerning how these Na(+) uptake mechanisms are fine tuned in response to the fluctuating FW environments. In this review, we summarize the current understanding of these three Na(+) uptake mechanisms and discuss their regulation by endocrine (cortisol and prolactin) and neurohumoral (catecholamines) factors.

  14. Fundamental symmetries in {sup 21}Na decay

    Energy Technology Data Exchange (ETDEWEB)

    Hoek, D.J. van der; Hoekstra, R.; Jungmann, K.; Kruithof, W.L.; Onderwater, C.J.G.; Sohani, M.; Willmann, L.; Wilschut, H.W. [KVI, University of Groningen, Groningen (Netherlands)

    2009-07-01

    The {beta}-{nu} correlations in {beta}-decay allows searching for contributions that go beyond the V-A description of the Standard Model for the electroweak interaction. We are developing an experimental setup to measure correlations in the {beta}-decay of {sup 21}Na. By trapping the radioactive atoms, the recoiling nucleus (kinetic energy <230 eV) can be measured in a reaction microscope in coincidence with the emitted {beta} particle. The first step is to study {beta}-{nu} correlations that allows to set limits on scalar and tensor contributions. By polarizing the parent nucleus it becomes possible to search for time reversal violation. The production and trapping of {sup 21}Na has been accomplished. Details of the setup with a two laser system and the status of this phase of the program are described.

  15. Kaizen: Uma Metodologia Inovadora na Siderurgia

    Directory of Open Access Journals (Sweden)

    Hericson Estanislau Prata

    2017-04-01

    Full Text Available A racionalização do processo produtivo industrial, por meio da redução dos desperdícios e da modernização do processo produtivo, com a adoção do Sistema Toyota de Produção (Produção Enxuta, tem sido adotada por uma parte importante das indústrias no mundo. O objetivo deste artigo é descrever essa metodologia empregada pelo grupo de melhoria de fase intensiva adotado na Vallourec Tubos do Brasil S.A. Como resultado, verificou-se que o processo utilizado para a implantação de mudanças em curto prazo foi a semana intensiva, também conhecida como evento Kaizen na indústria automotiva.

  16. NA62 experiment at CERN SPS

    Directory of Open Access Journals (Sweden)

    Kozhuharov Venelin

    2014-01-01

    Full Text Available The NA62 experiment at SPS is a continuation of the long standing CERN kaon physics program. The high statistics and the unprecedent precision allow to probe the Standard Model and test the description of the strong interactions at low energy. The final results on the the lepton universality test by measuring the ratio RK = Γ(K+ → e+ν/Γ(K+ → µ+ν and the study of the K± → π±γγ decay are presented. The major goal of the NA62 experiment is to perform a measurement of the Br(K+ → π+νν̄ with a precision of 10% in two years of data taking. The detector setup together with the analysis technique is described.

  17. Fotografia na rynku aukcyjnym w Polsce

    Directory of Open Access Journals (Sweden)

    Bednarek, Anna

    2012-09-01

    Full Text Available W artykule podjęta została analiza stanu aukcyjnego rynku fotografii w Polsce w oparciu o wyniki sprzedaży z okresu od pierwszej aukcji fotografii (1996 do końca 2011 roku. Dane te pozwalają czytelnikowi na zapoznanie się z rozmiarami tego rynku (obrót, liczba sprzedanych obiektów, charakterystyką nabywanych obiektów (rekordy cenowe, średnie ceny, popularni twórcy i okresy oraz z trudnościami, które można napotkać podczas badania tego zjawiska. W podsumowaniu znalazły się przewidywania dotyczące dalszego rozwoju rynku.

  18. Recent results from NA61/SHINE

    CERN Document Server

    Andronov, Evgeny

    2016-01-01

    The NA61/SHINE experiment aims to discover the critical point of strongly interacting matter and study the properties of the onset of deconfinement. For these goals a scan of the two dimensional phase diagram (T-$\\mu_B$) is being performed at the SPS by measurements of hadron production in proton-proton, proton-nucleus and nucleus-nucleus interactions as a function of collision energy and system size. In this contribution intriguing results on the energy dependence of hadron spectra and yields in inelastic p+p and centrality selected Be+Be collisions will be presented. In particular, the energy dependence of the signals of deconfinement, the 'horn', 'step' and 'kink', in p+p interactions will be presented and compared with the corresponding results from central Pb+Pb collisions from NA49.

  19. HUME E O EMPIRISMO NA MORAL

    Directory of Open Access Journals (Sweden)

    Adriano Naves de Brito

    2007-12-01

    Full Text Available O que pretendo defender neste texto é que uma posição empirista na moral é compatível com uma pretensão de validade intersubjetiva de juízos morais. Essa pretensão deve, nesse caso, estar calcada na naturalização dos fundamentos da moralidade, mas tem de conviver com limites acerca da justificação de enunciados de valor. Para defender esse ponto, sirvo-me da filosofia moral de Hume, como ele a expôs no seu texto Uma investigação sobre os princípios da moral. No que diz respeito à filosofia de Hume, o objetivo deste texto é explicitar o caráter empírico seja de seu método de investigação da moral, seja do princípio que para ela ele encontra.

  20. The NA60 experiment readout architecture

    CERN Document Server

    Floris, M; Usai, G L; David, A; Rosinsky, P; Ohnishi, H

    2004-01-01

    The NA60 experiment was designed to identify signatures of a new state of matter, the Quark Gluon Plasma, in heavy-ion collisions at the CERN Super Proton Synchroton. The apparatus is composed of four main detectors: a muon spectrometer (MS), a zero degree calorimeter (ZDC), a silicon vertex telescope (VT), and a silicon microstrip beam tracker (BT). The readout of the whole experiment is based on a PCI architecture. The basic unit is a general purpose PCI card, interfaced to the different subdetectors via custom mezzanine cards. This allowed us to successfully implement several completely different readout protocols (from the VME like protocol of the MS to the custom protocol of the pixel telescope). The system was fully tested with proton and ion beams, and several million events were collected in 2002 and 2003. This paper presents the readout architecture of NA60, with particular emphasis on the PCI layer common to all the subdetectors. (16 refs).

  1. O Personal Trainer na Perspectiva do Marketing

    Directory of Open Access Journals (Sweden)

    Cibele Biehl Bossle

    2011-03-01

    Full Text Available Esse estudo apresenta mapeamento das referências dedicadas à formação do personal trainer em bases de dados eletrônicas. Essa garimpagem revelou baixa produção científica sobre o assunto e mostrou que na literatura sobre personal trainer predominam livros com linguagem corrente no mundo dos negócios. Esses achados nos levaram a indagar sobre a força do discurso físico-empresarial, especialmente o marketing, na constituição desta ocupação profissional. Jeremy Rifkin, Zygmunt Bauman, Paula Sibilia e Denise Sant'Anna permitiram visualizar que o marketing dirigido ao personal trainer tem como tarefa reinventar, ressignificar e "repaginar" esta modalidade de serviço em nome da sobrevivência no disputado mercado da vida ativa.

  2. Luzes portuguesas na caverna do patriarcado brasileiro

    Directory of Open Access Journals (Sweden)

    Constância Lima Duarte

    2013-09-01

    Full Text Available Novas cartas portuguesas revelou literariamente as diversas formas de opressão a que as mulheres estavam submetidas através dos séculos, pela distorcida mística imposta pelo patriarcalismo – verdadeira caverna que cerceava o pensamento das mulheres e seu lugar na sociedade. A publicação do livro das três marias contribuiu para a formação de um senso crítico, ampliou a consciência feminista, e propiciou o surgimento de uma literatura engajada também entre nós. O texto pretende refletir sobre a repercussão da publicação da obra na mídia impressa e entre as feministas brasileiras.

  3. The two C-terminal tyrosines stabilize occluded Na/K pump conformations containing Na or K ions.

    Science.gov (United States)

    Vedovato, Natascia; Gadsby, David C

    2010-07-01

    Interactions of the three transported Na ions with the Na/K pump remain incompletely understood. Na/K pump crystal structures show that the extended C terminus of the Na,K-adenosine triphosphatase (ATPase) alpha subunit directly contacts transmembrane helices. Deletion of the last five residues (KETYY in almost all Na/K pumps) markedly lowered the apparent affinity for Na activation of pump phosphorylation from ATP, a reflection of cytoplasmic Na affinity for forming the occluded E1P(Na3) conformation. ATPase assays further suggested that C-terminal truncations also interfere with low affinity Na interactions, which are attributable to extracellular effects. Because extracellular Na ions traverse part of the membrane's electric field to reach their binding sites in the Na/K pump, their movements generate currents that can be monitored with high resolution. We report here electrical measurements to examine how Na/K pump interactions with extracellular Na ions are influenced by C-terminal truncations. We deleted the last two (YY) or five (KESYY) residues in Xenopus laevis alpha1 Na/K pumps made ouabain resistant by either of two kinds of point mutations and measured their currents as 10-mM ouabain-sensitive currents in Xenopus oocytes after silencing endogenous Xenopus Na/K pumps with 1 microM ouabain. We found the low affinity inhibitory influence of extracellular Na on outward Na/K pump current at negative voltages to be impaired in all of the C-terminally truncated pumps. Correspondingly, voltage jump-induced transient charge movements that reflect pump interactions with extracellular Na ions were strongly shifted to more negative potentials; this signals a several-fold reduction of the apparent affinity for extracellular Na in the truncated pumps. Parallel lowering of Na affinity on both sides of the membrane argues that the C-terminal contacts provide important stabilization of the occluded E1P(Na3) conformation, regardless of the route of Na ion entry into the

  4. The temperature dependence of the cross section for the energy pooling process Na(3P)+Na(3P) to Na(4D)+Na(3S)

    Science.gov (United States)

    Horvatic, V.; Movre, M.; Vadla, C.

    1999-10-01

    We report the measurements of the temperature dependence of the cross section σ4D for the energy pooling process Na(3P)+Na(3P) to Na(4D)+Na(3S). The latest two, as yet undisputed, results for σ4D obtained by different authors at T = 597 K and T = 483 K suggest that this cross section decreases with increasing T, which contradicts the theory and other experiments on similar processes. To resolve this controversy and to examine the temperature trend of the cross section, we have measured the σ4D in the temperature range 567-705 K, covering the high-temperature region that has not yet been investigated experimentally. To determine σ4D we have excited sodium atoms in the quasistatic wing of the D1 line using a cw dye laser and measured the fluorescence intensity for the 4D to 3P3/2 transition, relative to the intensity of the optically thin quasistatic wing of the D2 line. The spatial distribution of the number density of the sodium atoms in the 3P3/2 state and the sodium ground-state number density were measured too. The method used for the determination of the cross section is advantageous since it entirely circumvents the need to account for the radiation trapping of 3P level radiation, which was substantial under experimental conditions of the ground-state densities being 1014-1016 cm-3. The measurements of the cross section σ4D in the investigated temperature range have shown that it increases as ~exp(-Δ E/kT). From the experiment we obtained Δ E = (608±95) cm-1, which is in excellent agreement with the energy defect (613 cm-1) for the considered process, and in fair agreement with the values which follow from recent theoretical calculations.

  5. NA35: sulphur-gold collision

    CERN Multimedia

    1991-01-01

    In this image the real particles produced by the collision of a 6400 GeV sulphur ion with a gold target can be seen as they pass through a streamer chamber. Streamer chambers consist of a gas chamber through which a strong pulsed electric field is passed, creating sparks as a charged particle passes through it. The NA35 experiment, which was in operation in the 1980s, was part of CERN's ongoing heavy ion project.

  6. Acetylene diffusion in Na-Y zeolite

    Indian Academy of Sciences (India)

    S Mitra; S Sumitra; A M Umarji; R Mukhopadhyay; S Yashonath; S L Chaplot

    2004-08-01

    Study of diffusivity of acetylene adsorbed in Na-Y zeolite by quasi-elastic neutron scattering (QENS) measurements at temperatures of 300, 325 and 350 K is reported. A model in which the acetylene molecules undergo random-walk diffusion characterized by a Gaussian distribution of jump lengths inside zeolite cages describes the data consistently. The diffusion constant, residence time between jumps and root mean square jump length are determined.

  7. Prototype calorimeters for the NA3 experiment

    CERN Multimedia

    1975-01-01

    The NA3 Experiment was set-up on the North Area of the SPS by the CERN/ Ecole Polytechnique/College de France/ Orsay/Saclay Collaboration, to study high transverse momentum leptons and hadrons from hadron collisions. The calorimeters measured the energy of hadrons (prototype on the right) and leptons (prototype on the left). They used a new type of plastic scintillator (plexipop). (see CERN Courier of November 1975) energy (prototype on the right)

  8. Clubes carnavalescos negros na cidade de Pelotas

    Directory of Open Access Journals (Sweden)

    Loner, Beatriz Ana

    2009-01-01

    Full Text Available O artigo trata da organização negra na cidade de Pelotas, particularmente com relação aos seus clubes carnavalescos, que tiveram seu auge entre os anos de 1920 e 1950. Pretende-se descrever os principais clubes e sua evolução, analisando seu papel e sua importância para a comunidade negra pelotense

  9. SPLETNA TRGOVINA NA PRIMERU PORTALA EBAY

    OpenAIRE

    Babić, Aleksandra

    2012-01-01

    Prilagajanje spremembam v poslovnem okolju je temeljnega pomena za obstoj slehernega podjetja. Sodobno trženje postaja temeljna filozofija vseh sodobnih, tržno usmerjenih podjetij. Z elektronskim poslovanjem so podjetja s pomočjo računalnikov in informatizacije procesov posodobila del ali celotno poslovanje, kot na primer komunikacijo z dobavitelji in odjemalci, skladiščenje, distribucijo, trženje, prodajo in podobno. Vendar je elektronska trgovina le del elektronskega poslovanja podjetja. ...

  10. Posso ser eu mesmo na escola?

    Directory of Open Access Journals (Sweden)

    Wilton Orlando Trapp

    2012-04-01

    Full Text Available Este texto faz uma reflexão acerca da importância de se pensar a escola como um lugar da convivência humana e do respeito à cultura do brincar/jogar, trazendo contribuições à superação da influência mercadológica presente nas práticas de movimento e na forma de planejar o uso do espaço escolar.

  11. UPORABA KODE QR NA MOBILNIH NAPRAVAH

    OpenAIRE

    Taciga, Matej

    2013-01-01

    V diplomski nalogi je opisan je razvoj aplikacije za mobilno napravo na platformi Windows Phone, ki omogoča branje QR kode. Aplikacijo smo razvili v programskem jeziku C#. Zajete in opisane so možnosti uporabe QR kode. Opisano je testiranje obstoječih aplikacij s QR čitalci. Predstavljena sta tudi razvoj in struktura QR kode. S primerom je razloženo kako so podatki zakodirani v kodo.

  12. The NA62 experiment at CERN

    Science.gov (United States)

    Venditti, Stefano

    2016-12-01

    The goal of the NA62 experiment at CERN is to collect O(100) events of the ultrarare K+→ π +ν bar {ν } decay in two years. After a long R&D phase and a successful pilot run in 2014, the first data-taking phase took place in 2015. In this paper the importance of the experiment's physics goal, as well as the experimental solutions adopted in order to attain it, will be reviewed.

  13. Cultura Política na Antiguidade

    Directory of Open Access Journals (Sweden)

    José Petrúcio Farias Júnior

    2009-06-01

    Full Text Available

    Pretendemos discutir nesse artigo algumas implicações do termo cultura política na Antiguidade, especificamente, na sociedade romana imperial. Dessa forma, acreditamos que as considerações que apresentaremos a seguir contribuam para reflexão da utilização desse termo, produto das investigações contemporâneas, sobre os estudos das sociedades antigas. Para a historiadora Profa. Dra. Margarida Maria de Carvalho, tais reflexões representam ainda uma lacuna na historiografia concernente a essa temática. Isso posto, discorreremos, inicialmente, sobre o conceito de cultura e seus desdobramentos para, em seguida, refletirmos sobre o viés interpretativo que fundamenta estudos históricos que se desenvolvem sob o beneplácito da linha de pesquisa intitulada História e Cultura Política.

  14. Hadron production measurement from NA61/SHINE

    CERN Document Server

    Korzenev, A

    2013-01-01

    New results from the NA61/SHINE experiment on the determination of charged hadron yields in proton-carbon interactions are presented. They aim to improve predictions of the neutrino flux in the T2K experiment. The analysis is based on the main dataset collected by NA61/SHINE in the year 2009. The data were recorded using a secondary-proton beam of 31 GeV/$c$ momentum from CERN SPS which impinges on a graphite target. To determine the inclusive production cross section for charged pions, kaons and protons a thin target was exploited. Results of this measurement are used in the T2K beam simulation program to reweight hadron yields at the interaction vertex. At the same time, NA61/SHINE results obtained with the T2K replica target allow to constrain hadron yields at the surface of the target. This allows to constrain up to 90% of the neutrino flux, thus reducing significantly the model dependence of the neutrino beam prediction. All measured spectra are compared to predictions of hadron production models.

  15. Transplante pulmonar na infância

    Directory of Open Access Journals (Sweden)

    Camargo José J.

    2002-01-01

    Full Text Available Objetivos: este artigo faz uma revisão dos principais aspectos relacionados com o transplante pulmonar na população pediátrica, e traz a experiência da equipe pioneira na realização do procedimento na América Latina. Fontes de dados: foram utilizadas informações através de revisão bibliográfica, realizada por busca direta de artigos científicos e por pesquisa nas bases de dados Medline e Lilacs. Síntese dos dados: o artigo é estruturado em tópicos, nos quais procura identificar as semelhanças e as diferenças com o transplante pulmonar do adulto. Discute os problemas específicos da criança transplantada e enfatiza uma situação específica, a do transplante pulmonar com doadores vivos aparentados. Conclusões: os avanços observados no transplante pulmonar realizado em adultos, para tratamento de doenças pulmonares, parenquimatosas ou vasculares, têm sido transferidos, nos últimos anos, para a população pediátrica, com sucesso crescente.

  16. Imunossupressores na Dermatologia Immunosuppressive agents in Dermatology

    Directory of Open Access Journals (Sweden)

    Aline Lopes Bressan

    2010-02-01

    Full Text Available Os imunossupressores são drogas que agem na divisão celular e têm propriedades anti-inflamatórias. Sendo assim, são essencialmente prescritos na prevenção de rejeição de transplantes e no tratamento das doenças autoimunes e inflamatórias crônicas, que, na Dermatologia, têm a psoríase como maior representante. Nesta sessão serão descritas as principais drogas imunossupressoras, com orientações para seu manejo adequado.Immunosupressants are drugs that act in cell division and have anti-inflammatory effects. Therefore, they are essentially prescribed in the prevention of transplant rejection and in the treatment of autoimmune disorders and chronic inflammatory diseases, whose main example in Dermatology is psoriasis. In this work the most important immunosuppressive drugs and orientation to properly administer them are going to be described.

  17. Envolvimento do sistema nervoso central na cisticercose

    Directory of Open Access Journals (Sweden)

    Aristides Cheto de Queiroz

    1979-03-01

    Full Text Available No estudo do envolvimento do SNC na cisticercose, verificou-se uma freqüência de 0,3%, sempre como achado incidental no estudo de rotina de autópsias; apenas um caso mostrou boa correlação com a presença de manifestações neurológicas. Esta freqüência que é baixa em relação ao que é observado em outras regiões do Brasil, mostra que a neurocisticercose não representa um grande problema na região. As reações do hospedeiro ao embrião do cisticerco foram sempre do tipo inflamatório crônico e fibrosante. Neste estudo ficou demonstrada a importância do método de impregnação pela prata (Grocott na identificação do esqueleto do cisticerco no interior de lesões fibrosantes e/ou calcificadas.

  18. Resonances production from the NA60 experiment

    Directory of Open Access Journals (Sweden)

    De Falco A.

    2012-11-01

    Full Text Available The NA60 experiment at the CERN SPS has studied light vector meson production in In-In collisions at 158A GeV. The ϕ meson was detected via both the K+K− and the μ+μ− decay channels. The yields and inverse slope parameters of the mT spectra observed in the two channels are compatible within errors, different from the large discrepancies seen in Pb-Pb collisions between the hadronic (NA49 and dimuon (NA50 decay channels. In the invariant mass region 0.2 1 GeV, the excess is found to be prompt, with remarkable differences with respect to the Drell-Yan process. The Teff slope parameter, extracted from the transverse mass spectra, shows a rise with mass up to the ρ, followed by a sudden decline for higher masses. The former is consistent with radial flow of a hadronic source, while the latter suggests a dominantly partonic emission source.

  19. Report from the NA61/SHINE experiment

    CERN Document Server

    Aduszkiewicz, A

    2015-01-01

    This document reports on the status and plans of the NA61/SHINE experiment at the CERN SPS as of October 2015. First, an overview of the 2014 and 2015 data-taking period on p+Pb interactions at 158 GeV/c and Ar+Sc collisions at 13A GeV/c - 150A GeV/c is given. The latter data-taking with the first primary Ar beams at CERN was a major success. Second, the facility maintenance and upgrades are briefly presented. The VTX-1 magnet was damaged at the beginning of the 2015 proton period. The physics data-taking for p+p interactions at 400 GeV/c and for the Fermilab neutrino beams as well as the pilot data taking on Pb+Pb collisions at 30A GeV/c was replaced by detector tests and calibration runs. Third, the advance in the NA61/SHINE software and calibration procedures is briefly reported. Fourth, new physics results are presented. In particular, the very first results on Ar+Sc collisions are presented. Fifth, plans for data taking in 2016 - 2018 are outlined and ideas concerning the NA61/SHINE physics programme...

  20. Afasia adquirida na infância

    Directory of Open Access Journals (Sweden)

    Eliana C. Wanderley

    1969-06-01

    Full Text Available São relatados dois casos de afasia em menina de 10 anos e menino de 8 anos, conseqüentes a lesão cerebral por projétil de arma de fogo no primeiro caso e septicemia com tromboflebite no segundo. Nos dois casos a evolução foi bastante favorável e ambos os pacientes apresentaram percepção praticamente normal com distúrbios na expressão oral que assumia várias vezes o tipo de lapso amnéstico. A expressão gráfica nos dois casos foi mais atingida como sonseqüência de estar menos automatizada. O fenômeno da perseveração foi notado na fala no primeiro caso e, na escrita, no seguno. Foi discutida a justificativa do diagnóstico e lembrado o diagnóstico diferencial com outros distúrbios da fala em crianças.

  1. Regulation of paracellular Na+ and Cl(-) conductances by hydrostatic pressure.

    Science.gov (United States)

    Tokuda, Shinsaku; Niisato, Naomi; Nagai, Toshiki; Taruno, Akiyuki; Nakajima, Ken-Ichi; Miyazaki, Hiroaki; Yamada, Toshiki; Hosogi, Shigekuni; Ohta, Mariko; Nishio, Kyosuke; Iwasaki, Yoshinobu; Marunaka, Yoshinori

    2009-09-01

    The effect of hydrostatic pressure on the paracellular ion conductance (Gp) composed of the Na(+) conductance (G(Na)) and the Cl(-) conductance (G(Cl)) has been Investigated. Gp, G(Na) and G(Cl) were time-dependently increased after applying an osmotic gradient generated by NaCl with basolateral hypotonicity. Hydrostatic pressure (1-4cm H2O) applied from the basolateral side enhanced the osmotic gradient-induced increase in Gp, G(Na) and G(Cl) in a magnitude-dependent manner, while the hydrostatic pressure applied from the apical side diminished the osmotic gradient-induced increase in Gp, G(Na) and G(Cl). How the hydrostatic pressure influences Gp, G(Na) and G(Cl) under an isosmotic condition was also investigated. Gp, G(Na) and G(Cl) were stably constant under a condition with basolateral application of sucrose canceling the NaCl-generated osmotic gradient (an isotonic condition). Even under this stable condition, the basolaterally applied hydrostatic pressure drastically elevated Gp, G(Na) and G(Cl), while apically applied hydrostatic pressure had little effect on Gp, G(Na) or G(Cl). Taken together, these observations suggest that certain factors controlled by the basolateral osmolality and the basolaterally applied hydrostatic pressure mainly regulate the Gp, G(Na) and G(Cl).

  2. Spontaneous NA+ transients in individual mitochondria of intact astrocytes.

    Science.gov (United States)

    Azarias, Guillaume; Van de Ville, Dimitri; Unser, Michael; Chatton, Jean-Yves

    2008-02-01

    Mitochondria in intact cells maintain low Na(+) levels despite the large electrochemical gradient favoring cation influx into the matrix. In addition, they display individual spontaneous transient depolarizations. The authors report here that individual mitochondria in living astrocytes exhibit spontaneous increases in their Na(+) concentration (Na(mit)(+) spiking), as measured using the mitochondrial probe CoroNa Red. In a field of view with approximately 30 astrocytes, up to 1,400 transients per minute were typically detected under resting conditions. Na(mit)(+) spiking was also observed in neurons, but was scarce in two nonneural cell types tested. Astrocytic Na(mit)(+) spikes averaged 12.2 +/- 0.8 s in duration and 35.5 +/- 3.2 mM in amplitude and coincided with brief mitochondrial depolarizations; they were impaired by mitochondrial depolarization and ruthenium red pointing to the involvement of a cation uniporter. Na(mit)(+) spiking activity was significantly inhibited by mitochondrial Na(+)/H(+) exchanger inhibition and sensitive to cellular pH and Na(+) concentration. Ca(2+) played a permissive role on Na(mit)(+) spiking activity. Finally, the authors present evidence suggesting that Na(mit)(+) spiking frequency was correlated with cellular ATP levels. This study shows that, under physiological conditions, individual mitochondria in living astrocytes exhibit fast Na(+) exchange across their inner membrane, which reveals a new form of highly dynamic and localized functional regulation.

  3. Explosive phenomena in heavily irradiated NaCl

    NARCIS (Netherlands)

    denHartog, HW; Vainshtein, DI; Matthews, GE; Williams, RT

    1997-01-01

    In heavily irradiated NaCl crystals explosive phenomena can be initiated during irradiation or afterwards when samples are heated to temperatures between 100 and 250 degrees C. During irradiation of NaCl Na and Cl-2 precipitates and void structures are produced along with the accumulation of stored

  4. Stress of Cl- is Stronger than That of Na+ on Glycine max Seedlings Under NaCl Stress

    Institute of Scientific and Technical Information of China (English)

    LUO Qing-yun; YU Bing-jun; LIU You-liang

    2002-01-01

    Seedlings of six Glycine max cultivars were used to compare Cl- with Na+ in stress effects onsoybean seedlings under NaCl stress. Results showed that stress of NaCl on G. max seedlings was mainlycaused by Cl- and not by Na+. After treatment with isoosmotic solutions of Cl- (without Na+ ) and Na+ (with-out Cl-) respectively, fresh weight and height of G. max seedlings growing in solution of Cl- were much morestressed than those in solution of Na+. And the roots and leaves electrolyte leakage were much more increasedunder stress of Cl- than those under stress of Na+. Salt tolerance of G. max seedlings was mainly contributedto Cl- withheld in roots of seedlings to decrease its content in leaves.

  5. VISIBILIDADE GAY NA ESCOLA: ESTUDANTES QUEER

    Directory of Open Access Journals (Sweden)

    Aline Ferraz da Silva

    2008-03-01

    Full Text Available Nesse artigo apresento as considerações e análises presentes na pesquisa em processo, que realizo numa escola pública. Sua constituição deve seu primeiro movimento às manifestações de desconforto e homofobia com relação a um grupo específico de três estudantes gays na comunidade escolar na qual atuo como professora. Percebo que a presença desse grupo desacomoda o cotidiano escolar e desenvolvo minha argumentação com base no potencial desestabilizador desses sujeitos, na intenção de pensar o impensável no currículo escolar. Esse trabalho parte da visibilidade de uma identidade sexual que foge à norma heterossexual e desafia a tendência normalizadora e homogeneizadora da educação. A maneira como esse grupo gay se posiciona e constrói seus corpos cruza as fronteiras do masculino/feminino, desnaturalizando as identidades sexuais e de gênero que se baseiam em características biológicas e se apresentando como diferença que escapa às classificações binárias. Na construção da pesquisa utilizo como referência o pensamento de Michel Foucault, especialmente com relação à construção histórica e discursiva de conceitos como sexualidade, identidade, diferença e normalidade que têm servido para criação e manutenção de padrões de conduta. Ao levar a problematização desses conceitos para o contexto escolar, considero produtiva a teorização queer para pensar a possibilidade de uma educação não heteronormativa, produtora de diferenças, que desconstrua identidades ao invés de tentar cristalizá-las.

  6. Reflectivity of NaK Droplets

    Science.gov (United States)

    Wiedemann, C.; Oswald, M.; Stabroth, S.; Klinkrad, H.; Vörsmann, P.

    An important contribution to the space debris population near 900 km orbital altitude are the NaK droplets. Sixteen nuclear powered satellites of the type RORSAT launched between 1980 and 1988 activated a reactor core ejection system close to this altitude. The core ejection causes an opening of the primary coolant circuit. The liquid coolant has been released into space during these core ejections, forming droplets up to a diameter of 5.5 cm. These droplets consist of an alloy of two alkali metals, sodium and potassium (NaK). In this paper the monochromatic and the total reflectivity of NaK is calculated using theoretical models. The reflectivity depends on the alloy composition and temperature of a droplet. The alloy composition may change due to evaporation, resulting in an enrichment of sodium especially at the droplet surface. According to the literature, there is only a limited number of available measurement data concerning the optical properties of NaK alloys. Furthermore the published data for pure sodium and potassium are controversial. Thus it is necessary to investigate the optical properties of alkali metals and their alloys. Mainly two types of optical absorption, the intraband and the interband absorption, are considered. The intraband absorption is calculated using the Drude-model which uses electrical properties to derive the optical constants of pure metals or alloys. Drude assumes that the valence electrons can be treated as free electrons. The electrons behave like an ideal gas of uncharged particles. The theory of free electrons is a very simple model for the description of the valence electrons in metals. This assumption is sufficient for alkali metals, because they show a nearly free electron behavior. For the interband absorption the classical Butcher-model is used. Furthermore an absorption anomaly which has been observed in some alkali metals is discussed. Especially for potassium, some measurements revealed an unexpected absorption in the

  7. Route, mechanism, and implications of proton import during Na+/K+ exchange by native Na+/K+-ATPase pumps.

    Science.gov (United States)

    Vedovato, Natascia; Gadsby, David C

    2014-04-01

    A single Na(+)/K(+)-ATPase pumps three Na(+) outwards and two K(+) inwards by alternately exposing ion-binding sites to opposite sides of the membrane in a conformational sequence coupled to pump autophosphorylation from ATP and auto-dephosphorylation. The larger flow of Na(+) than K(+) generates outward current across the cell membrane. Less well understood is the ability of Na(+)/K(+) pumps to generate an inward current of protons. Originally noted in pumps deprived of external K(+) and Na(+) ions, as inward current at negative membrane potentials that becomes amplified when external pH is lowered, this proton current is generally viewed as an artifact of those unnatural conditions. We demonstrate here that this inward current also flows at physiological K(+) and Na(+) concentrations. We show that protons exploit ready reversibility of conformational changes associated with extracellular Na(+) release from phosphorylated Na(+)/K(+) pumps. Reversal of a subset of these transitions allows an extracellular proton to bind an acidic side chain and to be subsequently released to the cytoplasm. This back-step of phosphorylated Na(+)/K(+) pumps that enables proton import is not required for completion of the 3 Na(+)/2 K(+) transport cycle. However, the back-step occurs readily during Na(+)/K(+) transport when external K(+) ion binding and occlusion are delayed, and it occurs more frequently when lowered extracellular pH raises the probability of protonation of the externally accessible carboxylate side chain. The proton route passes through the Na(+)-selective binding site III and is distinct from the principal pathway traversed by the majority of transported Na(+) and K(+) ions that passes through binding site II. The inferred occurrence of Na(+)/K(+) exchange and H(+) import during the same conformational cycle of a single molecule identifies the Na(+)/K(+) pump as a hybrid transporter. Whether Na(+)/K(+) pump-mediated proton inflow may have any physiological or

  8. The relation between aging, aortic NaF avidity and coronary artery NaF avidity: A NaF PET CT study

    DEFF Research Database (Denmark)

    Blomberg, Björn; Thomassen, Anders; Hildebrandt, Malene;

    2013-01-01

    volunteers without traditional cardiovascular risk factors were prospectively assessed by Sodium 18-Fluoride (Na-18F) PET CT imaging. Global aortic uptake of Na-18F was determined by calculating the average aortic blood pool subtracted maximum standardized uptake value (cSUV) [maximum SUVaorta - mean...... SUVblood pool]. Global uptake of Na-18F in the coronary arteries was determined by calculating the average heart blood pool subtracted maximum SUV [maximum SUVheart - mean SUVblood pool]. Calculating regression and correlation coefficients summarized the data. Results: A strong linear relationship...... was observed between aortic and coronary artery Na-18F avidity (Pearson’s r = 0.83 [95% CI; 0.49, 0.95]; t statistic = 4.71; P = 0.0008). A quadratic relationship was observed between aging and aortic Na-18F avidity. Also, a quadratic relationship was observed between aging and coronary artery Na-18F uptake...

  9. Na+ channel function, regulation, structure, trafficking and sequestration

    Science.gov (United States)

    Chen-Izu, Ye; Shaw, Robin M; Pitt, Geoffrey S; Yarov-Yarovoy, Vladimir; Sack, Jon T; Abriel, Hugues; Aldrich, Richard W; Belardinelli, Luiz; Cannell, Mark B; Catterall, William A; Chazin, Walter J; Chiamvimonvat, Nipavan; Deschenes, Isabelle; Grandi, Eleonora; Hund, Thomas J; Izu, Leighton T; Maier, Lars S; Maltsev, Victor A; Marionneau, Celine; Mohler, Peter J; Rajamani, Sridharan; Rasmusson, Randall L; Sobie, Eric A; Clancy, Colleen E; Bers, Donald M

    2015-01-01

    This paper is the second of a series of three reviews published in this issue resulting from the University of California Davis Cardiovascular Symposium 2014: Systems approach to understanding cardiac excitation–contraction coupling and arrhythmias: Na+ channel and Na+ transport. The goal of the symposium was to bring together experts in the field to discuss points of consensus and controversy on the topic of sodium in the heart. The present review focuses on Na+ channel function and regulation, Na+ channel structure and function, and Na+ channel trafficking, sequestration and complexing. PMID:25772290

  10. Effect of Na+ on surface fractal dimension of compacted bentonite

    Science.gov (United States)

    Xiang, G. S.; Xu, Y. F.; Jiang, H.

    2015-05-01

    Compacted Tsukinuno bentonite was immersed into NaCl solutions of different concentrations in oedometers, and the surface fractal dimension of bentonite-saline association was measured by nitrogen adsorption isotherms. The application of the Frenkel-Halsey-Hill equation and the Neimark thermodynamic method to nitrogen adsorption isotherms indicated that the surface roughness was greater for the bentonite-saline association. The surface fractal dimension of bentonite increased in the NaCl solution with low Na+ concentration, but decreased at high Na+ concentration. This process was accompanied by the same tendency in specific surface area and microporosity with the presence of Na+ coating in the clay particles.

  11. VPLIV NADZORA ZAPOSLENIH NA NJIHOVO VEDENJE IN MOTIVACIJO PRI DELU

    OpenAIRE

    Marinšek, Teja

    2011-01-01

    Nadzor na delovnem mestu je sodoben problem, v katerem smo udeleženi vsi. Z vedno manjšim zaupanjem med nadrejenimi in podrejenimi se nadzor poostruje in s tem se tudi pritiski na delovnem mestu povečujejo. V diplomskem delu smo raziskovali predvsem vpliv nadzora na vedenje človeka. Zanimalo nas je, kako tak pritisk vpliva na človeka in njegove spremembe v obnašanju. Ali nanj to vpliva pozitivno in motivacijsko ali deluje na človeka negativno. Obravnavali smo tudi zakone, ki opredeljujejo...

  12. NA48 experiment : view along the NA48 beamline with the detector in the distance.

    CERN Multimedia

    Hans Taureg

    1996-01-01

    Photo 02: Side view of the NA48 experiment showing the LKR calorimeter cryostat No one is sure why the Universe wound up the way it has: all matter and no antimatter. According to prevailing theories, the early universe had equal amounts of matter and antimatter. To see what might be missing from the theories, physicists search for the rare cases in which matter and antimatter behave differently. One such imbalance, called direct CP violation, showed up in the NA 31 experiment at CERN. The results from this experiment, first presented in 1993, showed that when K mesons and their antimatter cousins decay, they show a slight preference for matter over antimatter. Later experiments with neutral K mesons, including NA48 at CERN and KTeV at Fermilab in the United States, showed direct CP violation is real.

  13. A coprecipitation technique to prepare NaNbO3 and NaTaO3

    Indian Academy of Sciences (India)

    V Samuel; A B Gaikwad; V Ravi

    2006-04-01

    A simple coprecipitation technique has been used successfully for the preparation of pure, ultrafine, single phases of NaNbO3 (NN) and NaTaO3 (NT). An alcoholic solution of ammonium carbonate and ammonium hydroxide was used to precipitate Na+ and Nb5+ (or Ta5+) cations under basic conditions as carbonate and hydroxide, respectively. On heating at 700°C, these precursors produce respective products. For comparison, both NN and NT powders were also prepared by the traditional solid state method. The phase purity and lattice parameters were studied by powder X-ray diffraction (XRD). The particle size and morphology were studied by scanning electron microscopy (SEM).

  14. Jahn–Teller Assisted Na Diffusion for High Performance Na Ion Batteries

    Energy Technology Data Exchange (ETDEWEB)

    Li, Xin [Harvard Univ., Cambridge, MA (United States). John A. Paulson School of Engineering and Applied Sciences; Wang, Yan [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Dept. of Materials Science and Engineering; Wu, Di [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Dept. of Mechanical Engineering; Liu, Lei [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Dept. of Materials Science and Engineering; Bo, Shou-Hang [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Dept. of Materials Science and Engineering; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Dept. of Materials Science and Engineering; Ceder, Gerbrand [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Dept. of Materials Science and Engineering; Univ. of California, Berkeley, CA (United States). Dept. of Materials Science and Engineering

    2016-08-30

    Na energy storage technology is strategically attractive for large scale applications such as grid energy storage. Here, we show in this paper that there is a clear relation between the Jahn$-$Teller activity of a transition metal ion at the end of charge and the mobility of Na in a cathode material. This is particularly important as mobility at the end of charge limits the capacity of current materials. Consequently, by using this classical piece of physics in the battery world, it is possible to create higher capacity Na-cathode materials. Even more exciting is that the ideal element to impart this effect on cathodes is Fe, which is the least expensive of the transition metal oxides and can therefore enable low cost cathode materials.

  15. Recent results from NA61/SHINE and comparison to NA49

    CERN Document Server

    Mackowiak-Pawlowska, Maja

    2013-01-01

    The NA61/SHINE experiment aims to discover the critical point of strongly interacting matter and study properties of the onset of deconfinement. It also performs precise hadron production measurements for the neutrino and cosmic rays experiments. These goals are being achieved by measurements of hadron production properties in nucleus-nucleus, proton-proton and proton/pion-nucleus interactions as a function of collision energy and size of the colliding nuclei. This contribution presents preliminary results from the NA61 ion program on single-particle spectra and identified particle multiplicity fluctuations in p+p interactions at the CERN SPS. Comparisons with results from p+p and Pb+Pb collisions obtained by the NA49 experiment are shown.

  16. Na,K-pump modulates intercellular communication in vascular wall

    DEFF Research Database (Denmark)

    Matchkov, Vladimir; Nilsson, Holger; Aalkjær, Christian

      Ouabain, a specific inhibitor of the Na,K-pump, has previously been shown to interfere with intercellular communication. Here we test the hypothesis that the communication between vascular smooth muscle cells (SMCs) is regulated through an interaction between the Na,K-pump and the Na,Ca-exchanger....... Immunohistochemical analysis suggested that a ouabain-sensitive α2 isoform of the Na,K-pump involved in this interaction. The experiments suggest that the Na,K-pump may affect gap junction conductivity via localized changes in intracellular calcium concentration through modulation of Na,Ca-exchanger activity....... were used as a model for electrical coupling of SMCs by measuring membrane capacitance (Cm). SMCs were uncoupled (evaluated by inhibition of vasomotion and desynchronization of calcium transients in vascular wall, or by reduction to half of Cm measured in paired A7r5 cells) when the Na,K-pump...

  17. Tecnologias na Web 2.0 : o empoderamento na educação aberta

    OpenAIRE

    Santarosa, Lucila Maria Costi; Conforto, Debora; Schneider, Fernanda Chagas

    2013-01-01

    Esse artigo problematiza a utilização de recursos educacionais abertos, na perspectiva da web 2.0, como tecnologias impulsionadoras de movimentos educativos formais e não formais. Por meio de experiências na formação de educadores em cursos de pós-graduação, discutimos o conceito de empoderamento e os princípios que estruturam a Educação Aberta, para referendar a importância de aproximar sujeitos em processo de formação de sistemas Web abertos instituindo e ampliando os tempos-espaços da apre...

  18. Dieta rica em proteína na redução do peso corporal

    OpenAIRE

    Pedrosa,Rogerio Graça; DONATO JUNIOR, Jose; Tirapegui, Julio

    2009-01-01

    A proporção ideal dos macronutrientes em dietas de emagrecimento é atualmente bastante discutida. Existem evidências de que dietas com maior proporção de proteína aumentam a perda de peso e de gordura corporal e diminuem a perda de massa corporal magra durante o emagrecimento. Todavia, os mecanismos responsáveis por estes efeitos não estão totalmente esclarecidos. Além disso, existem poucas conclusões a respeito dos possíveis efeitos colaterais dessas dietas na função renal e no estado nutric...

  19. Direct Reactions with MoNA-LISA

    Science.gov (United States)

    Kuchera, Anthony

    2016-03-01

    Nuclear reactions can be used to probe the structure of nuclei. Direct reactions, which take place on short time scales, are well-suited for experiments with beams of short-lived nuclei. One such reaction is nucleon knockout where a proton or neutron is removed from the incoming beam from the interaction with a target. Single nucleon knockout reactions have been used to study the single-particle nature of nuclear wave functions. A recent experiment at the National Superconducting Cyclotron Laboratory was performed to measure cross sections from single nucleon knockout reactions for several p-shell nuclei. Detection of the residual nucleus in coincidence with any gamma rays emitted from the target allowed cross sections to ground and excited states to be measured. Together with input from reaction theory, ab initio structure theories can be tested. Simultaneously the accuracy of knockout reaction models can be validated by detecting the knocked out neutron with the Modular Neutron Array and Large multi-Institutional Scintillator Array (MoNA-LISA). Preliminary results from this experiment will be shown. Knockout reactions can also be used to populate nuclei which are neutron unbound, thus emit neutrons nearly instantaneously. The structure of these nuclei, therefore, cannot be probed with gamma ray spectroscopy. However, with large neutron detectors like MoNA-LISA the properties of these short-lived nuclei are able to be measured. Recent results using MoNA-LISA to study the structure of neutron-rich nuclei will be presented. The author would like to acknowledge support from the NNSA and NSF.

  20. NaI(Tl) response functions

    Energy Technology Data Exchange (ETDEWEB)

    Vega C, H. R.; Ortiz R, J. M. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas, Zac. (Mexico); Benites R, J. L. [Centro Estatal de Cancerologia de Nayarit, Calz. de la Cruz 118 Sur, Tepic, Nayarit (Mexico); De Leon M, H. A., E-mail: fermineutron@yahoo.com.mx [Instituto Tecnologico de Aguascalientes, Av. Adolfo Lopez Mateos 1801 Ote., 20155 Aguascalientes, Ags. (Mexico)

    2015-09-15

    The response functions of a NaI(Tl) detector have been estimated using Monte Carlo methods. Response functions were calculated for monoenergetic photon sources (0.05 to 3 MeV). Responses were calculated for point-like sources and for sources distributed in Portland cement cylinders. The responses were used to calculate the efficiency functions in term of photon energy. Commonly, sources used for calibration are point-like, and eventually sources to be measured have different features. In order to use the calibrated sources corrections due to solid angle, self-absorption and scattering, must be carried out. However, some of these corrections are not easy to perform. In this work, the calculated responses were used to estimate the detector efficiency of point-like sources, and sources distributed in Portland type cement. Samples of Portland paste were prepared and were exposed to photoneutrons produced by a 15 MV linac. Some of the elements in the cement were activated producing γ-emitting radionuclides that were measured with a NaI(Tl) gamma-ray spectrometer, that was calibrated with point-like sources. In order to determine the specific activity in the induced radioisotopes calculated efficiencies were used to make corrections due to the differences between the solid angle, photon absorption and photon scattering in the point-like calibration sources and the sources distributed in cement. During the interaction between photoneutrons and the cement samples three radioisotopes were induced: {sup 56}Mn, {sup 24}Na, and {sup 28}Al. (Author)

  1. Linguagens na TV Languages on tv

    Directory of Open Access Journals (Sweden)

    Glaucia Guimarães

    2008-06-01

    Full Text Available Este artigo aborda questões relativas às estratégias discursivas utilizadas na produção dos textos televisivos. Com base na Análise Crítica de Discurso (ACD, nos termos em que é formulada por Norman Fairclough, o trabalho analisa os modos pelos quais as linguagens (incluindo materiais semióticos diversos são articuladas na/pela TV, sistematiza as relações entre a articulação de linguagens e a produção de efeitos de sentido, bem como os modos de sua inscrição nas tendências discursivas contemporâneas, a saber: democratização, tecnologização e comodificação. A partir das relações entre as práticas de linguagem e as tendências destacadas, o artigo tece considerações sobre as condições de produção de leituras críticas dos textos multimidiáticos, nas suas múltiplas dimensões: dos contextos e mecanismos da produção textual à pluralidade constitutiva de sua recepção.This paper deals with issues related to discursive strategies in the production of TV texts. Based on Critical Discourse Analysis (CDA, as formulated by Norman Fairclough, it analyzes the ways languages (including several semiotic materials are articulated in order to produce a range of wanted meaning effects, as well as the ways they are inscribed in the contemporary discursive trends discussed by the author, namely: democratization, technologization and commodification. Departing from the analysis of language practices and the discursive trends underlined, the paper aims at clarifying the multiple dimensions of multimedia conditions of production, focusing on both the context and the mechanisms and the diverse reception (reading possibilities.

  2. Reinterpretacija na krilatata zmija (drakon v hristijanskata tradicija: Po povod ukrasata na Divoševoto evangelie

    Directory of Open Access Journals (Sweden)

    Džurova Aksinija

    2009-01-01

    Full Text Available (bugarski V statijata se razgležda edin ot motivite v ukrasata na Divoševoto evangelie ot XIV v. - tozi na krilatija drakon (na mesta s kozja glava i podobnata na nego ukrasa v sr'bski, gr'cki i ruski r'kopisi, povlijani v svojata dekoracija ot romanskoto izkustvo, koeto ot svoja strana interpretira rannohristijanski motivi, vlezli v r'kopisnija repertoar na gr'ckite kodeksi ošče prez X-XI v. i otnovo pojavili se v k'snovizantijskata tradicija.

  3. VPLIV GLASOVNEGA ZAVEDANJA NA PISANJE IN BRANJE

    OpenAIRE

    Lahovnik, Janja

    2010-01-01

    Prvo triletje osnovne šole pokriva prvo fazo opismenjevanja, to je učenje branja in pisanja, ob tem pa razvijanje sposobnosti poslušanja in govorjenja. Prvi je proces dekodiranja besed oziroma vzpostavitev odnosa med črko in glasom. Najprej učenci spoznajo znake za črke in glasove, nato pa sledita branje in pisanje. Drugi proces zajema uporabo govornih sposobnosti, ki se kažejo na razumevanju prepoznanih besed. Obvladovanje abecednega zapisovanja zahteva sposobnosti zavedanja besed, zlogov in...

  4. As emoções na fala

    OpenAIRE

    Rodrigues, Américo Jorge Monteiro

    2007-01-01

    No presente trabalho analisamos algumas características acústicas (duração, frequência fundamental, F1 e F2) de um pequeno corpus de “voz emocional”, em Português Europeu, gravado por um actor. Procedemos também a testes de percepção desse corpus, a que se submeteu um grupo diversificado e o informante. Reflectimos também acerca do envolvimento emocional dos actores na construção de personagens, usando a voz. ABSTRACT: In the present work we analyse several acoustic charac...

  5. MICOTOXINAS DO FUSARIUM spp NA AVICULTURA COMERCIAL

    OpenAIRE

    Santin, Elizabeth; Maiorka,Alex; Zanella,Irineo; Magon,Leandro

    2001-01-01

    Micotoxinas são metabólitos tóxicos produzidos por fungos, de natureza heterogênea e com variados princípios farmacológicos, que podem atuar sobre o organismo animal prejudicando o seu desempenho e desenvolvendo alterações patológicas graves. Nos últimos anos, as micotoxicoses têm recebido especial atenção devido às enormes perdas que vem causando na avicultura mundial. Fungos do gênero Fusarium são descritos como produtores de diversos tipos de toxinas. Assim sendo, as intoxicações causadas ...

  6. Results on leptonic probes from NA50

    CERN Document Server

    Alessandro, B; Arnaldi, R; Atayan, M; Baglin, C; Baldit, A; Bedjidian, Marc; Beolè, S; Boldea, V; Bordalo, P; Borenstein, S R; Borges, G; Bussière, A; Capelli, L; Castanier, C; Castor, J I; Chaurand, B; Cheynis, B; Chiavassa, E; Cicalò, C; Claudino, T; Comets, M P; Constantinescu, S; Cortese, P; Cruz, J; De Falco, A; De Marco, N; Dellacasa, G; Devaux, A; Dita, S; Drapier, O; Espagnon, B; Fargeix, J; Force, P; Gallio, M; Gavrilov, Yu K; Gerschel, C; Giubellino, P; Golubeva, M B; Gonin, M; Grigorian, A A; Grigorian, S; Grossiord, J Y; Guber, F F; Guichard, A; Gulkanian, H R; Hakobyan, R S; Haroutunian, R; Idzik, M; Jouan, D; Karavitcheva, T L; Kluberg, L; Kurepin, A B; Le Bornec, Y; Lourenço, C; Macciotta, P; MacCormick, M; Marzari-Chiesa, A; Masera, M; Masoni, A; Monteno, M; Musso, A; Petiau, P; Piccotti, A; Pizzi, J R; Prado da Silva, W L; Prino, F; Puddu, G; Quintans, C; Ramello, L; Ramos, S; Rato-Mendes, P; Riccati, L; Romana, A; Santos, H; Saturnini, P; Scalas, E; Scomparin, E; Serci, S; Shahoyan, R; Sigaudo, F; Sitta, M; Sonderegger, P; Tarrago, X; Topilskaya, N S; Usai, G L; Vercellin, Ermanno; Villatte, L; Willis, N; Wu, T

    2003-01-01

    The NA50 Collaboration has performed a new measurement of the J/ psi yield in Pb-Pb collisions at 158 GeV/nucleon in improved experimental conditions. Our preliminary analysis of the year 2000 data sample, while confirming the onset of anomalous suppression and the non saturation of the J/ psi /Drell-Yan cross-section ratio, shows that peripheral Pb-Pb interactions follow the normal nuclear absorption pattern, which has in turn been established more precisely thanks to high statistics p-A data. (11 refs).

  7. DEPRESSÃO E ENVELHECIMENTO NA CONTEMPORANEIDADE

    Directory of Open Access Journals (Sweden)

    Delia Catullo Goldfarb

    2010-02-01

    Full Text Available RESUMO: O presente texto reproduz os trabalhos apresentados em mesa redonda sobre depressão e envelhecimento na contemporaneidade no III Congresso Ibero-americano de Psicogerontologia, realizado em novembro de 2010 em São Paulo. Estes trabalhos são resultado de reflexões precedentes em um grupo de estudos e de discussão de casos clínicos composto por psicanalistas. A depressão é uma figura psicopatológica de presença maciça nos dias de hoje. Na velhice o acúmulo de perdas e a aproximação da morte podem produzir um estado de tristeza, fundo depressivo que caracteriza um momento de recolhimento em que ocorrem os processos de luto. Em alguns sujeitos o que se verifica é a instalação de um episódio depressivo que indica a paralisação destes processos elaborativos e a progressão de um esvaziamento do sentido para a vida, restando, neste contexto, apenas a espera pela morte. Neste trabalho serão discutidos aspectos que concernem a vivência destas duas modalidades de enfrentamento da entrada na velhice, levando-se em conta as maneiras como a cultura pode favorecer a ocorrência destes percursos distintos do envelhecer, e como ela os aloja atualmente em um movimento de desconsideração da subjetividade: desanimo da velhice ou problema neuroquímico? Serão apresentadas hipóteses para a produção da depressão como psicopatologia no envelhecimento e reflexões sobre observações clínicas que derivam destes quadros clínicos, tais como: a crise da percepção da entrada na velhice, o corpo hipocondríaco, a paralisia do tempo, a vivência do desamparo. Palavras-chave: depressão, envelhecimento, cultura, corpo, tempo

  8. Da mulher na Bíblia

    Directory of Open Access Journals (Sweden)

    Jacó Guinsburg

    2013-03-01

    Full Text Available Este artigo discute a figura e a representação da mulher na Bíblia. Elas são multidão no relato bíblico. Desde Eva, a cada página surge um vulto de mulher. Virtuoso ou pecador, desalmado ou abnegado, terno ou tirânico, ele suscita, hoje como outrora, a impressão viva de um temperamento, de um gesto, de um sentimento. O jogo sutil da psicologia e das motivações femininas, das suas relações com o mundo masculino, continua palpitando nas heroínas das Escrituras.

  9. Laparoscopia na abordagem inicial de tumores anexiais

    OpenAIRE

    2014-01-01

    OBJETIVO: Avaliar o uso da laparoscopia como método diagnóstico e terapêutico na abordagem inicial de tumores anexiais em população de risco para malignidade, bem como fatores clínicos associados à falha do método e conversão para laparotomia, e comparar taxas de complicação com pacientes cuja abordagem inicial se deu por laparotomia. MÉTODOS: Estudo prospectivo com 210 mulheres com exames de imagem prévios constando tumor an...

  10. O satanismo na obra de Julio Perneta

    OpenAIRE

    Natalia Simões de Vicente

    2004-01-01

    Resumo: Este trabalho consiste, primeiramente, na compilação da obra de Júlio Perneta. Como conseqüência da compilação, passa-se a fazer a análise dos recursos literários utilizados, pelo poeta, para a construção de uma atmosfera satânica nos livros Bronzes e Malditos. inicialmente, para melhor situar o autor e sua obra, discutem-se o contexto histórico e cultural do Simbolismo no Brasil e em Curitiba, bem como se estuda o movimento anticlerical paranaense, do qual o poeta fez parte. A seg...

  11. Sindromi prenaprezanja na potkoljenici i stopalu

    OpenAIRE

    Smerdelj, Miroslav; Madjarević, Mladen; OREMUŠ, KREŠIMIR

    2002-01-01

    U radu autori opisuju i objašnjavaju nastanak bolnih sindroma u području potkoljenice i stopala, vezanih uz profesiju odnosno sportsku aktivnost. Iznose se zapažanja i iskustva iz svakodnevne liječničke prakse, a i podaci iz novije medicinske literature. Značenje se daje liječenju koje je obično konzervativno, a od kirurških metoda naglasak se daje na nove manje invazivne metode. U radu su opisani najčešći sindromi prenaprezanja u području potkoljenice kao što su trkačka potkoljenica, sindrom...

  12. Cerenkov counter for the experiment NA3

    CERN Multimedia

    1978-01-01

    The program of the NA3 experiment included the study of hadronic interactions with a large transverse momentum pT, thus the inclusion in the set-up of three gas threshold Cerenkov counters of large acceptance. The photo shows the downstream part of the second Cerenkov (located at the output of the magnet). The yellow membrane is a temporary protection for the optics (shown in photo 7810540X) to be taken away when fixing this part to the gas tank (entering the magnet and not shown). The photomultipliers all around are heavily shielded.

  13. DESENVOLVIMENTO MORAL E INDISCIPLINA NA ESCOLA

    Directory of Open Access Journals (Sweden)

    Rita Melissa Lepre

    2009-12-01

    Full Text Available O presente artigo configura-se como uma reflexão acerca da indisciplina e suas possíveis causas. Para debater sobre o assunto apresentamos a teoria do desenvolvimento moral de Jean Piaget e articulamos suas descobertas com a questão da indisciplina na escola. São feitas, ainda, reflexões sobre o ambiente em que nossas crianças encontram-se inseridas por, pelo menos, cinco horas diárias.

  14. Ensino de geometria descritiva: inovando na metodologia

    Directory of Open Access Journals (Sweden)

    Regina Coeli Moraes Kopke

    2001-03-01

    Full Text Available Com base na observação, durante anos de magistério superior, na área de desenho, dos alunos de Engenharia, Matemática, Arquitetura e Artes, quanto às dificuldades encontradas por eles no aprendizado de desenho, em especial da Geometria Descritiva, é que nos propusemos, em 1999, lecionar essa disciplina para os cursos de Arquitetura e Artes, adotando uma metodologia diferente da convencional, para despertar, no aluno, o gosto pela disciplina e o desenvolvimento de uma habilidade pouco trabalhada na escola: a visão espacial. Mostrar para os alunos que essa disciplina não é difícil, mas apenas diferente daquilo que estudaram até então, tornou-se nossa meta. A visão espacial é uma habilidade mental localizada no lado direito do cérebro e, assim, quanto mais lúdica for esta aprendizagem, será mais bem assimilada. A proposta é iniciada no sentido de se trabalhar primeiro com sólidos: neles estarão os pontos, retas e planos normalmente abordados na metodologia convencional, nessa ordem. Como conclusão, tem-se que o importante é ressaltar o grande avanço que a Geometria Descritiva traz para quem quer representar graficamente qualquer coisa. Onde há planejamento, projeto e representação gráfica, aí estará a Geometria Descritiva.During many years observing the teaching of design at the Engineering, Mathematics, Architeture and Arts courses, we can note the difficulties of the students to learn it, specially the descriptive geometry. Because of that, we decided to teach this discipline to the Architeture and Arts courses, using a new metodology to make the students motivated to study and to learn, and trying to develop their their spatial vision. We want to show to the students that this discipline is not so difficult as they think, but show them that is only different. The spatial vision is a mental skill found at the right side of the brain and the more soft the learning is, the more it is assimilated by the brain. The

  15. The NA62 Gigatracker pixel detector system

    Energy Technology Data Exchange (ETDEWEB)

    Mazza, G., E-mail: mazza@to.infn.i [INFN, sezione di Torino, 10125 Torino (Italy); Ceccucci, A. [CERN, CH-1211, Geneva 23 (Switzerland); Cortina, E. [UCL, Louvain la Neuve (Belgium); Cotta Ramusino, A. [INFN, sezione di Ferrara, 44100 Ferrara (Italy); Dellacasa, G. [INFN, sezione di Torino, 10125 Torino (Italy); Fiorini, M. [CERN, CH-1211, Geneva 23 (Switzerland); Garbolino, S. [INFN, sezione di Torino, 10125 Torino (Italy); Jarron, P.; Kaplon, J.; Kluge, A. [CERN, CH-1211, Geneva 23 (Switzerland); Marchetto, F. [INFN, sezione di Torino, 10125 Torino (Italy); Martin, E. [UCL, Louvain la Neuve (Belgium); Martoiu, S. [INFN, sezione di Torino, 10125 Torino (Italy); Noy, M. [CERN, CH-1211, Geneva 23 (Switzerland); Petrucci, F. [INFN, sezione di Ferrara, 44100 Ferrara (Italy); Riedler, P. [CERN, CH-1211, Geneva 23 (Switzerland); Rivetti, A. [INFN, sezione di Torino, 10125 Torino (Italy); Tiuraniemi, S. [CERN, CH-1211, Geneva 23 (Switzerland)

    2010-05-21

    The silicon tracker for the NA62 experiment has to provide both a time resolution of 150 ps rms and a space resolution of about 100{mu}mrms. These challenging specifications require the development of a new readout electronics in order to address the problem of measuring the tracks arrival time with such a high channel density. Moreover, the high particle density (up to 1.5MHz/mm{sup 2} in the center and 0.8-1 GHz in total) requires a high speed measurement and data transmission in order to keep the dead time below 1%.

  16. Bullying e peer status na escola

    OpenAIRE

    Sequeira, Paulo Jorge Ferreira Pinto

    2009-01-01

    O presente trabalho propõe-se realizar, na sequência da Suficiência Investigadora que se debruçou genericamente sobre o tema do bullying (acoso escolar), uma análise exaustiva da associação entre a estrutura sócio-afectiva (peer status) em sala de aula e a incidência de bullying (acoso moral), em alunos do 4.º ano de escolaridade. Sustentar-se-á essa análise no marco teórico validado em sede de defesa da suficiência, devidamente actualizado e direccionado para a reflexão autora...

  17. Erro humano na saúde

    OpenAIRE

    Seitz, Eva Maria

    2015-01-01

    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Produção, Florianópolis, 2015. O presente estudo foi desenvolvido com o objetivo propor diretrizes para impedir ocorrência do erro no preparo, administração e monitoramento de Medicamentos Potencialmente Perigosos (MPPs) por via intravenosa em um Serviço de Emergência Adulto num hospital escola, com ênfase na ergonomia, visando à segurança do paciente e trabalhadores. O...

  18. The NA62 experiment at CERN

    Science.gov (United States)

    Piccini, Mauro

    2016-11-01

    The rare decays K → πvv¯ are excellent processes to make tests of new physics at the highest scale complementary to LHC thanks to their theoretically cleanness. The NA62 experiment at CERN SPS aims to collect of the order of 100 events in two years of data taking for the decay K+ → π+vv¯, keeping the background at the level of 10%. Part of the experimental apparatus has been commissioned during a technical run in 2012. The diverse and innovative experimental techniques will be explained and some preliminary results obtained during the 2014 pilot run will be reviewed.

  19. The NA62 experiment at CERN

    Directory of Open Access Journals (Sweden)

    Piccini Mauro

    2016-01-01

    Full Text Available The rare decays K → πvv̄ are excellent processes to make tests of new physics at the highest scale complementary to LHC thanks to their theoretically cleanness. The NA62 experiment at CERN SPS aims to collect of the order of 100 events in two years of data taking for the decay K+ → π+vv̄, keeping the background at the level of 10%. Part of the experimental apparatus has been commissioned during a technical run in 2012. The diverse and innovative experimental techniques will be explained and some preliminary results obtained during the 2014 pilot run will be reviewed.

  20. Status of the NA62 Experiment

    Science.gov (United States)

    Palladino, Vito

    2016-04-01

    The rare decays {{{K}}^ + } to {π ^ + }{{ν bar ν }} are excellent processes to make tests of new physics at the highest scale complementary to LHC thanks to their theoretically cleaness. The NA62 experiment at CERN SPS aims to collect of the order of 100 events in two years of data taking, keeping the background at the level of 10%. Part of the experimental apparatus has been commissioned during a technical run in 2012. The physics prospects and the status of the experiment will be reviewed after the commissioning run of 2014 and the data taking in 2015.

  1. SMIČNA STABILNOST MOTORNIH ULJA

    OpenAIRE

    Cerny, Jaroslav; Vaclavickova, Ivana

    2006-01-01

    Sažetak U radu se sažimaju utjecaji na viskoznost motornoga ulja, poput smične stabilnosti modifikatora viskoznosti, udjela goriva i/ili čađe te degradacije ulja izazvane toplinskom oksidacijom. Značaj pojedinačnih vidova praćen je za nekoliko motornih ulja različitih gradacija viskoznosti cestovnim radom vozila s benzinskim motorom, kao i onih s dizelovim motorima. Trendovi promjene viskoznosti praćeni su i procjenjivani.

  2. Torcicolo adquirido na criança

    OpenAIRE

    Regala, Joana; Martins, Joana; Dias, Ana Isabel; Moreira, Ana; Neves, Manuel Cassiano

    2013-01-01

    O torcicolo adquirido na criança é uma manifestação clínica de múltiplas etiologias possíveis, que se podem agrupar em entidades musculoesqueléticas de origem traumática, infecciosa, inflamatória e tumoral, e entidades não musculo-esqueléticas de origem neurológica, oftalmológica, otorrinolaringológica,gastroenterológica e tumoral do sistema nervoso central. Assim existe um amplo espectro de gravidade,desde processos benignos e autolimitados tal como o torcicolo traumático até quadros graves ...

  3. A celulose na farmácia

    OpenAIRE

    Lima Neto, Severino Antonio de; Petrovick, Pedro Ros

    1997-01-01

    Derivados de celulose ocupam um lugar de destaque entre os adjuvantes farmacêuticos modernos. A ampla gama de aplicação da celulose e de seus derivados abrange das formas farmacêuticas sólidas, como aglutinantes, desintegrantes ou filmógenos, até formas farmacêuticas semi-sólidas, onde são empregados, especialmente como formadores de hidrogéis. Esta revisão apresenta alguns dos compostos de celulose mais empregados na prática farmacêutica como adjuvantes farmacêuticos, dando ênfase aos adjuva...

  4. Ajustamento emocional e coping na compulsividade sexual

    OpenAIRE

    2012-01-01

    Nos últimos anos a comunidade científica tem prestado especial atenção às características do comportamento sexual compulsivo, bem como da sua etiologia e conceptualização, existindo ainda alguma controvérsia relativamente a estes quesitos. O presente estudo teve como objectivos analisar o papel do ajustamento emocional/psicopatologia na compulsividade sexual em jovens/estudantes universitários de ambos os sexos, assim como avaliar se a resposta sexual (desejo e excitação sex...

  5. Interactions between Na+ channels and Na+-HCO3- cotransporters in the freshwater fish gill MR cell: a model for transepithelial Na+ uptake.

    Science.gov (United States)

    Parks, Scott K; Tresguerres, Martin; Goss, Greg G

    2007-02-01

    Isolated mitochondria-rich (MR) cells from the rainbow trout gill epithelium were subjected to intracellular pH (pH(i)) imaging with the pH-sensitive dye BCECF-AM. MR cells were categorized into two distinct functional subtypes based on their ability to recover pH(i) from an NH(4)Cl-induced acidification in the absence of Na(+). An apparent link between resting pH(i) and Na(+)-independent pH(i) recovery was made. We observed a unique pH(i) acidification event that was induced by extracellular Na(+) addition. This further classified the mixed MR cell population into two functional subtypes: the majority of cells (77%) demonstrated the Na(+)-induced pH(i) acidification, whereas the minority (23%) demonstrated an alkalinization of pH(i) under the same circumstances. The focus of this study was placed on the Na(+)-induced acidification and pharmacological analysis via the use of amiloride and phenamil, which revealed that Na(+) uptake was responsible for the intracellular acidification. Further experiments revealed that pH(i) acidification could be abolished when Na(+) was allowed entry into the cell, but the activity of an electrogenic Na(+)-HCO(3)(-) cotransporter (NBC) was inhibited by DIDS. The electrogenic NBC activity was supported by a DIDS-sensitive, Na(+)-induced membrane potential depolarization as observed via imaging of the voltage-sensitive dye bis-oxonol. We also demonstrated NBC immunoreactivity via Western blotting and immunohistochemistry in gill tissue. We propose a model for transepithelial Na(+) uptake occurring via an apical Na(+) channel linked to a basolateral, electrogenic NBC in one subpopulation of MR cells.

  6. Novel regulation of cell [Na(+)] in macula densa cells: apical Na(+) recycling by H-K-ATPase.

    Science.gov (United States)

    Peti-Peterdi, János; Bebok, Zsuzsa; Lapointe, Jean-Yves; Bell, P Darwin

    2002-02-01

    Na-K-ATPase is the nearly ubiquitous enzyme that maintains low-Na(+), high-K(+) concentrations in cells by actively extruding Na(+) in exchange for K(+). The prevailing paradigm in polarized absorbing epithelial cells, including renal nephron segments and intestine, has been that Na-K-ATPase is restricted to the basolateral membrane domain, where it plays a prominent role in Na(+) absorption. We have found, however, that macula densa (MD) cells lack functionally and immunologically detectable amounts of Na-K-ATPase protein. In fact, these cells appear to regulate their cytosolic [Na(+)] via another member of the P-type ATPase family, the colonic form of H-K-ATPase, which is located at the apical membrane in these cells. We now report that this constitutively expressed apical MD colonic H-K-ATPase can function as a Na(H)-K-ATPase and regulate cytosolic [Na(+)] in a novel manner. This apical Na(+)-recycling mechanism may be important as part of the sensor function of MD cells and represents a new paradigm in cell [Na(+)] regulation.

  7. [Effects of NaCl stress on the seedling growth and K(+)- and Na(+) -allocation of four leguminous tree species].

    Science.gov (United States)

    Mo, Hai-Bo; Yin, Yun-Long; Lu, Zhi-Guo; Wei, Xiu-Jun; Xu, Jian-Hua

    2011-05-01

    Taking the pot-cultured seedlings of four leguminous tree species (Albizia julibrissin, Robinia pseudoacacia, Sophora japonica, and Gleditsia sinensis) as test materials, this paper studied their growth indices, critical salt concentration (C50), and K+ and Na+ allocation under different levels of NaCl stress, aimed to understand the difference of test tree species in salt tolerance. NaCl stress inhibited the seedling growth of the tree species. Under NaCl stress, the dry matter accumulation decreased, while the root/shoot ratio increased, especially for A. julibrissin and G. sinensis. Quadratic regression analysis showed that the C50 of A. julibrissin, R. pseudoacacia, S. japonica, and G. sinensis was 3.0 per thousand, 5.0 per thousand, 4.5 per thousand, and 3.9 per thousand, respectively, i.e., the salt tolerance of the four tree species was in the order of R. pseudoacacia > S. japonica > G. sinensis > A. julibrissin. In the root, stem, and leaf of the four tree species seedlings, the Na+ content increased with the increase of NaCl stress, while the K+ content (except in the root of A. julibrissin) decreased after an initial increase, resulting in a larger difference in the K+/Na+ ratio in the organs. Under the same NaCl stress, the allocation of Na+ in different organs of the four tree species seedlings decreased in the order of root>stem>leaf, while that of K+ differed with tree species and NaCl stress, and leaf was the main storage organ for K+. The K+/Na+ ratio in different organs decreased in the sequence of leaf>stem>root. R. pseudoacacia under NaCl stress accumulated more K+ and less Na+ in stem and leaf, and had higher K+/Na+ ratio in all organs and higher dry mass, being assessed to be more salt-tolerant. In contrast, A. julibrissin under high NaCl stress accumulated more Na+ in stem and leaf, and had a lower K+/Na+ ratio in all organs and lower dry mass, being evaluated to be lesser salt-tolerant. The K+ accumulation in seedling stem and leaf and the Na

  8. Preparation and characterization of Na3BO3–Na2SO4 glass electrolytes with Na+ ion conductivity prepared by a mechanical milling technique

    Directory of Open Access Journals (Sweden)

    Kenji Suzuki

    2016-03-01

    Full Text Available The (100 − xNa3BO3·xNa2SO4 (0 ≤ x (mol% ≤ 50 glasses were prepared by mechanical milling. Halo patterns were observed in the compositions 0 ≤ x ≤ 50 by XRD measurements. The Raman spectra indicated that all the glasses were composed of BO33− anions, SO42− anions and Na+ cations. The (100 − xNa3BO3·xNa2SO4 glasses showed good deformation properties and a dense pellet was prepared by cold-press. The conductivities of the glasses increased with increasing Na2SO4 content, and the 50Na3BO3·50Na2SO4 glass showed the highest conductivity of 5.9 × 10−8 S cm−1 at 25 °C.

  9. NaSrMn2F7, NaCaFe2F7, and NaSrFe2F7: novel single crystal pyrochlore antiferromagnets

    Science.gov (United States)

    Sanders, M. B.; Krizan, J. W.; Plumb, K. W.; McQueen, T. M.; Cava, R. J.

    2017-02-01

    The crystal structures and magnetic properties of three previously unreported A2B2F7 pyrochlore materials, NaSrMn2F7, NaCaFe2F7, and NaSrFe2F7 are presented. In these compounds, either S  =  2Fe2+ or S  =  5/2Mn2+ is on the B site, while nonmagnetic Na and Ca (Na and Sr) are disordered on the A site. The materials, which were grown as crystals via the floating zone method, display high effective magnetic moments and large Curie-Weiss thetas. Despite these characteristics, no ordering transition is detected. However, freezing of the magnetic spins, characterized by peaks in the susceptibility or specific heat, is observed at very low temperatures. The empirical frustration index, f  =  -θ CW/T f, for the materials are 36 (NaSrMn2F7), 27 (NaSrFe2F7), and 19 (NaCaFe2F7). AC susceptibility, DC susceptibility, and heat capacity measurements are used to characterize the observed spin glass behavior. The results suggest that the compounds are frustrated pyrochlore antiferromagnets with weak bond disorder. The magnetic phenomena that these fluoride pyrochlores exhibit, in addition to their availability as relatively large single crystals, make them promising candidates for the study of geometric magnetic frustration.

  10. Hadron production measurement from NA61/SHINE

    CERN Document Server

    Korzenev, A

    2013-01-01

    New results of NA61/SHINE on determination of charged hadron yields in proton-carbon interactions are presented. They aim to improve predictions of the neutrino flux in the T2K experiment. The data were recorded using a secondary-proton beam of 31 GeV/$c$ momentum from CERN SPS which impinges on a graphite target. To determine the inclusive production cross section for charged pions, kaons and protons the thin ($0.04\\, \\lambda_I$) target was exploited. Results of this measurement are used in the T2K beam simulation program to reweight hadron yields in the interaction vertex. At the same time, NA61/SHINE results obtained with the T2K replica target ($1.9\\, \\lambda_I$) allow to constrain hadron yields at the surface of the target. It would correspond to the constraint up to 90% of the neutrino flux, thus reducing significantly a model dependence of the neutrino beam prediction. All measured spectra are compared to predictions of hadron production models. In addition a status of the analysis of data collected by...

  11. A biotecnologia na agropecuária

    Directory of Open Access Journals (Sweden)

    João Lúcio de Azevedo

    1986-11-01

    Full Text Available This review reports the use of biotechnology in agriculture and animal husbandry. The main techniques and the most important products both in experimental stage or in commercial use are reported. The work intends to give a global vision to the theme, chronologically and spacely, showing the main lines of research and what has been obtained in this area. The techniques and products that are related to genetics and breeding are emphasized. Revisão Bibliográfica do emprego da biotecnologia na agropecuária, mostrando um levantamento das técnicas mais promissoras e de seus principais produtos, tanto em fase experimental como em uso comercial. Pretende-se dar uma visão global do assunto, cronológica e espacialmente, não se prendendo à detalhes, mostrando, em Unhas gerais, o que foi feito e o que se faz, atualmente, em biotecnologia. As técnicas e produtos que influenciam a área de genética e melhoramento genético na agropecuária, são enfatizadas.

  12. Vinhos, Turismo e Pluriatividade na Agricultura

    Directory of Open Access Journals (Sweden)

    Hernanda Tonini

    2013-06-01

    Full Text Available A gastronomia, além de ter importante relação com a economia, é uma forma expressiva da cultura dos indivíduos, desde o tipo de alimentos cultivados até a maneira de seu preparo e consumo. O presente artigo propõe-se a analisar a relação entre o enoturismo – centralizado na existência do vinho enquanto elemento gastronômico – e o fenômeno da pluriatividade na agricultura familiar, vista nos últimos anos como alternativa positiva para sua reprodução econômica e social. O fluxo turístico em regiões vitivinícolas gera novas oportunidades de trabalho e faz com que agricultores e suas famílias dividam a mão de obra agrícola, até então direcionada ao cultivo da uva e outros alimentos para subsistência, com atividades não agrícolas – como o artesanato, o acolhimento de visitantes em pousadas, a atuação em restaurantes, entre outras – como chance de subsistência. Este panorama transforma as realidades do mundo rural, alterando a relação do agricultor com a produção de alimentos e a forma como o mesmo os utiliza, além de reestruturar o ambiente sociocultural no seu entorno.  

  13. Direito do poeta na literatura de cordel

    Directory of Open Access Journals (Sweden)

    Sale Mário Gaudêncio

    Full Text Available Este artigo apresenta uma análise situacional dos direitos autorais na literatura de cordel, especialmente no que se refere à proteção moral e patrimonial que é dada aos poetas populares. Justifica-se o estudo em função de não haver profundas nem atuais discussões teóricas sobre a preservação moral e patrimonial em torno das obras de cordel. Utiliza-se como metodologia a pesquisa bibliográfica relacionada a um corpusque analisa os folhetos impressos por poetas da literatura de cordel. O estudo mostra como resultados o estabelecimento de um modelo alternativo de prazos para os direitos autorais na poesia popular, além da necessidade de ruptura técnica, política e cultural. Conclui informando sobre a importância de se construir um banco de dados nacional para que se tenha conhecimento pleno do quê e como se está produzindo a literatura de cordel, além de saber quem verdadeiramente está sendo beneficiado com tais produções.

  14. Autonomia e vulnerabilidade na vida dos adolescentes

    Directory of Open Access Journals (Sweden)

    Renata R. de Oliveira

    2007-05-01

    Full Text Available Este trabalho foi realizado com a finalidade de estabelecer relações entre os princípios éticos da autonomia e vulnerabilidade e a vida de adolescentes, pessoas reconhecidamente passíveis de síndromes depressivas, uso abusivo de drogas ilícitas, alcoolismo e tabagismo. Famílias desestruturadas, pais ausentes, companhia de amigos que levam a diferentes vícios, facilidade de acesso a fontes desencontradas de informações e uma sociedade indiferente afetam o desenvolvimento normal dos jovens. Considera-se, ainda, o grande desafio apresentado a profissionais de saúde em agir na busca de reduzir a vulnerabilidade dos adolescentes e permitir que os mesmo usem de autonomia com responsabilidade na tomada de decisões em suas vidas pessoais. O cuidado com os mesmos deve ser mais integral e ativo e a sociedade ainda não reconheceu adequadamente a importância de cuidar do desenvolvimento saudável desse imenso contingente humano.

  15. Plantas indicadoras de clomazone na fase vapor

    Directory of Open Access Journals (Sweden)

    Fábio Schreiber

    2013-10-01

    Full Text Available A volatilização representa um processo importante no deslocamento de agrotóxicos para o ambiente. As características físico-químicas da molécula do clomazone indicam que este possui potencial de volatilização. Em vista do exposto, para a realização deste estudo, foram conduzidos dois experimentos com o objetivo de avaliar a suscetibilidade das espécies: pepino, melão, milho, sorgo e arroz a diferentes formulações do herbicida clomazone na fase vapor. Para isso, foram utilizadas caixas de vidro hermeticamente fechadas, com a presença de diferentes formulações de clomazone e as espécies vegetais. As formulações utilizadas foram Gamit 360 CS®, Gamit 500 EC® e Gamit Star®. Com os resultados obtidos, foi possível concluir que, dentre as espécies avaliadas, independente da formulação utilizada, a de menor tolerância ao herbicida clomazone na fase vapor foi o sorgo, seguido do milho e do arroz.

  16. Mercosul educativo na carreira de Enfermagem

    Directory of Open Access Journals (Sweden)

    Roseli Schmoeller

    2012-10-01

    Full Text Available O Mercosul, instituído com vistas à integração econômica, política, social e cultural entre os países membros, atualmente destaca-se pelas estratégias integrativas de âmbito educacional. Este artigo aborda os movimentos acerca da formação acadêmica dos cursos de Enfermagem e o trajeto histórico de integração educacional, apresentando o Sistema de Acreditação dos Cursos Universitários do Mercosul, o ARCU-SUL, além dos setores responsáveis por esse processo e as perspectivas para a Enfermagem nos países do Mercosul. Entendemos que para o desenvolvimento de profissionais críticos, reflexivos e com compromisso político-social, é fundamental investir na formação e na qualidade dos centros de ensino em Enfermagem.

  17. The NA62 GigaTracker

    CERN Document Server

    Perrin-Terrin, Mathieu

    2015-01-01

    The GigaTracker is an hybrid silicon pixel detector built for the NA62 experiment aiming at measuring the branching fraction of the ultra-rare kaon decay K + ! p + n ̄ n at the CERN SPS. The detector has to track particles in a beam with a flux reaching 1.3 MHz/mm 2 and provide single-hit timing with 200ps RMS resolution for a total material budget of less than 1.5 X 0 . The tracker comprises three 60.8mm 27mm stations installed in vacuum ( 10$^{-6}$ mbar) and cooled with liquid C 6 F 14 circulating through micro-channels etched inside few hundred of microns thick silicon plates. Each station is composed of a 200 m m thick silicon sensor readout by 2 x 5 cus- tom 100 m m thick ASIC, called TDCPix. Each chip contains 40 x 45 asynchronous pixels, each 300 m m x 300 m m and is instrumented with 100ps bin time-to-digital converters. In order to cope with the high rate, the TDCPix is equipped with four 3.2Gb/s serialisers sending out the data. We will describe the detector and the results from the 2014 NA62 ru...

  18. Hydrogen sulfide induced disruption of Na+ homeostasis in the cortex.

    Science.gov (United States)

    Chao, Dongman; He, Xiaozhou; Yang, Yilin; Balboni, Gianfranco; Salvadori, Severo; Kim, Dong H; Xia, Ying

    2012-07-01

    Maintenance of ionic balance is essential for neuronal functioning. Hydrogen sulfide (H(2)S), a known toxic environmental gaseous pollutant, has been recently recognized as a gasotransmitter involved in numerous biological processes and is believed to play an important role in the neural activities under both physiological and pathological conditions. However, it is unclear if it plays any role in maintenance of ionic homeostasis in the brain under physiological/pathophysiological conditions. Here, we report by directly measuring Na(+) activity using Na(+) selective electrodes in mouse cortical slices that H(2)S donor sodium hydrosulfide (NaHS) increased Na(+) influx in a concentration-dependent manner. This effect could be partially blocked by either Na(+) channel blocker or N-methyl-D-aspartate receptor (NMDAR) blocker alone or almost completely abolished by coapplication of both blockers but not by non-NMDAR blocker. These data suggest that increased H(2)S in pathophysiological conditions, e.g., hypoxia/ischemia, potentially causes a disruption of ionic homeostasis by massive Na(+) influx through Na(+) channels and NMDARs, thus injuring neural functions. Activation of delta-opioid receptors (DOR), which reduces Na(+) currents/influx in normoxia, had no effect on H(2)S-induced Na(+) influx, suggesting that H(2)S-induced disruption of Na(+) homeostasis is resistant to DOR regulation and may play a major role in neuronal injury in pathophysiological conditions, e.g., hypoxia/ischemia.

  19. NaCl处理对盐地碱蓬开花及Na+、K+含量的影响%Effects of NaCl Treatments on Flower Number, Na+and K+Contents of Suaeda salsa

    Institute of Scientific and Technical Information of China (English)

    郭建荣; 王宝山

    2014-01-01

    To investigate the role of salinity in lfowering of euhalophyte Suaeda salsa, lfower number of differ-ent branches and per plant, Na+, K+content and Na+/K+ratio of leaves, stems and lfowers of S. salsa were deter-mined under conditions of 1 (control), 200 and 400 mmol·L-1 NaCl treatment. Compared with the control, 200 mmol·L-1NaCl treatment signiifcantly increased the lfower number of branches and individual plant of S. salsa, the lfower number per plant increased by 69.90%, Na+content, Na+/K+ratio in the lfowers increased by 1.41 and 1.77 times respectively, Na+content, Na+/K+ratio in the leaves of the ifrst branches increased by 3.96 and 4.96 times respectively, and Na+content, Na+/K+ratio in the stems increased by 7.00 and 12.39 times respectively. Flower number per plant increased by 19.00%under 400 mmol·L-1 NaCl treatment, Na+content and Na+/K+ra-tio in lfowers increased by 2.09 and 3.21 times respectively, Na+content, Na+/K+ratio in the leaves of the ifrst branches increased by 4.28 and 6.50 times respectively, and Na+content, Na+/K+ratio in the stems increased by 7.65 and 15.40 times respectively. These results suggested that certain concentration of external NaCl promotes lfowering of euhalophytes S. salsa possibly via compartmentalization of Na+into leaves and stems and mobili-zation of K+in the leaves and stems into the lfowers to maintain a proper Na+/K+ratio in the lfowers.%为探讨盐地碱蓬(Suaeda salsa)开花与盐的关系,研究了1(对照)、200和400 mmol·L-1 NaCl处理对盐地碱蓬不同分枝和单株开花数目、叶片和茎及花器官中的Na+、K+含量及Na+/K+比的影响。结果表明:与对照相比,200 mmol·L-1 NaCl处理下盐地碱蓬分枝及单株开花数目增加最显著,单株开花数目增加了69.90%,花器官中的Na+含量、Na+/K+比分别增加了1.41倍和1.77倍,而一级叶片的Na+含量、Na+/K+比分别增加了3.96倍和4.96倍,茎中Na+含量、Na+/K+比分别增加了7.00倍和12.39倍。400 mmol

  20. Apical Na+ permeability of frog skin during serosal Cl- replacement.

    Science.gov (United States)

    Leibowich, S; DeLong, J; Civan, M M

    1988-05-01

    Gluconate substitution for serosal Cl- reduces the transepithelial short-circuit current (Isc) and depolarizes short-circuited frog skins. These effects could result either from inhibition of basolateral K+ conductance, or from two actions to inhibit both apical Na+ permeability (PapNa) and basolateral pump activity. We have addressed this question by studying whole-and split-thickness frog skins. Intracellular Na+ concentration (CcNa) and PapNa have been monitored by measuring the current-voltage relationship for apical Na+ entry. This analysis was conducted by applying trains of voltage pulses, with pulse durations of 16 to 32 msec. Estimates of PapNa and CcNa were not detectably dependent on pulse duration over the range 16 to 80 msec. Serosal Cl- replacement uniformly depolarized short-circuited tissues. The depolarization was associated with inhibition of Isc across each split skin, but only occasionally across the whole-thickness preparations. This difference may reflect the better ionic exchange between the bulk medium and the extracellular fluid in contact with the basolateral membranes, following removal of the underlying dermis in the split-skin preparations. PapNa was either unchanged or increased, and CcNa either unchanged or reduced after the anionic replacement. These data are incompatible with the concept that serosal Cl- replacement inhibits PapNa and Na,K-pump activity. Gluconate substitution likely reduces cell volume, triggering inhibition of the basolateral K+ channels, consistent with the data and conclusions of S.A. Lewis, A.G. Butt, M.J. Bowler, J.P. Leader and A.D.C. Macknight (J. Membrane Biol. 83:119-137, 1985) for toad bladder. The resulting depolarization reduces the electrical force favoring apical Na+ entry. The volume-conductance coupling serves to conserve volume by reducing K+ solute loss. Its molecular basis remains to be identified.

  1. Aspectos valorizados por porfissionais de enfermagem na higiene pessoal e na higiene corporal do paciente

    Directory of Open Access Journals (Sweden)

    Elóide André Oliveira

    2003-10-01

    Full Text Available Survey descritivo, com o qual se objetivou identificar que aspectos da higiene corporal são valorizados pelos componentes da equipe de enfermagem, na higiene corporal pessoal e na higiene corporal do paciente. A pesquisa foi desenvolvida em oito instituições públicas de saúde e a amostra foi composta por 126 profissionais de enfermagem, correspondendo a 12,8% do total de 986 componentes das equipes de enfermagem destas instituições. Na higiene corporal pessoal, chamou a atenção o fato de que os cuidados com as unhas e com os cabelos tenham suplantado, no número de citações dos profissionais de enfermagem, aspectos básicos como o cuidado com as mãos. Na higiene corporal do paciente, o banho foi o aspecto considerado mais importante pelas três categorias profissionais; a higiene oral, pelas(os enfermeiras(os e auxiliares de enfermagem; e as unhas, pelas(os enfermeiras(os e técnicas(os de enfermagem.

  2. Theoretical calculation of low-lying states of NaAr and NaXe

    Science.gov (United States)

    Laskowski, B. C.; Langhoff, S. R.; Stallcop, J. R.

    1981-01-01

    Potential curves as well as dipole moments and linking transition moments are calculated for the ground X 2 Sigma + and low lying excited A 2 Pi, B 2 Sigma +, C 2 Sigma +, (4) 2 Sigma +, (2) 2 Pi and (1) 2 Delta states of NaAr and NaXe. Calculations are performed using a self-consistent field plus configuration-interaction procedure with the core electrons replaced by an ab initio effective core potential. The potential curves obtained are found to be considerably less repulsive than the semiempirical curves of Pascale and Vandeplanque (1974) and to agree well with existing experimental data, although the binding energies of those states having potential minima due to van der Waals interactions are underestimated. Emission bands are also calculated for the X 2 Sigma + - C 2 Sigma + excimer transitions of NaAr and NaXe using the calculated transition moments and potential curves, and shown to agree well with experiment on the short-wavelength side of the maximum.

  3. Polarization and Velocity Dependence of Associative Ionization in Na(3p)+Na(3p) Collisions

    NARCIS (Netherlands)

    Meijer, H.A.J.; Meulen, H.P. van der; Morgenstern, R.

    1987-01-01

    We have excited Na atoms of two counterrunning thermal beams by means of linearly polarized laser light and have investigated associative ionization processes. To this end we measured the total ionization signal as a function of the angle θ between light polarization and the relative collision veloc

  4. Na+ overload during ischemia and reperfusion in rat hearts : Comparison of the Na+/H+ exchange blockers EIPA, cariporide and eniporide

    NARCIS (Netherlands)

    ten Hove, M; van Emous, JG; van Echteld, CJA

    2003-01-01

    Intracellular myocardial Na+ overload during ischemia is an important cause of reperfusion injury via reversed Na+/Ca2+ exchange. Prevention of this Na+ overload can be accomplished by blocking the different Na+ influx routes. In this study the effect of ischemic inhibition of the Na+/H+ exchanger (

  5. Efeito do plasma de oxigênio na dentina previamente exposta ao NaOCl

    Directory of Open Access Journals (Sweden)

    Maíra do PRADO

    Full Text Available Resumo Introdução O tratamento de plasma é uma tecnologia eficaz que pode manter as propriedades internas dos materiais inalteradas após o tratamento, modificando apenas a superfície. Objetivo Avaliar o efeito do plasma de oxigênio na dentina previamente exposta ao NaOCl 6%. Material e método Foram utilizados 60 incisivos bovinos. A coroa foi removida, a raiz foi dividida e as faces planificadas, totalizando 120 segmentos referentes ao terço cervical. As amostras foram divididas em dois grupos: controle (imersa em NaOCl 6%, lavada com água destilada, seca, imersa em EDTA 17%, lavada e seca e plasma de oxigênio (após tratamento descrito no grupo controle, plasma de oxigênio foi aplicado por 30 s. As amostras foram avaliadas qualitativamente em relação à topografia por microscopia eletrônica de varredura, utilizando-se microfotografias com ampliação de 1.000×. O goniômetro Ramé-hart foi utilizado para a mensuração do ângulo de contato entre as superfícies e as seguintes soluções foram utilizadas: água, etilenoglicol e di-iodometano. Em seguida, a energia de superfície, representada pelas componentes polar e dispersiva, foi calculada. Avaliou-se também o escoamento dos cimentos Pulp Canal Sealer EWT (PCS e Real Sal SE (RS na superfície dentinária. Os dados foram analisados estatisticamente utilizando os testes Kruskal-Wallis e Mann-Whitney U (p<0,05. Resultado O tratamento com plasma levou à formação de uma camada semelhante à smear layer na superfície dentinária. Este tratamento levou a um aumento da energia de superfície e da componente polar, favorecendo a hidrofilicidade da superfície. Entretanto, desfavoreceu o escoamento do cimento PCS e não influenciou no escoamento do cimento RS. Conclusão O plasma de oxigênio ocasionou mudanças topográficas na superfície dentinária, favorecendo a hidrofilicidade desta. Contudo, não favoreceu o escoamento dos cimentos endodônticos na dentina.

  6. Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels.

    Science.gov (United States)

    Aman, Teresa K; Grieco-Calub, Tina M; Chen, Chunling; Rusconi, Raffaella; Slat, Emily A; Isom, Lori L; Raman, Indira M

    2009-02-18

    The beta subunits of voltage-gated Na channels (Scnxb) regulate the gating of pore-forming alpha subunits, as well as their trafficking and localization. In heterologous expression systems, beta1, beta2, and beta3 subunits influence inactivation and persistent current in different ways. To test how the beta4 protein regulates Na channel gating, we transfected beta4 into HEK (human embryonic kidney) cells stably expressing Na(V)1.1. Unlike a free peptide with a sequence from the beta4 cytoplasmic domain, the full-length beta4 protein did not block open channels. Instead, beta4 expression favored open states by shifting activation curves negative, decreasing the slope of the inactivation curve, and increasing the percentage of noninactivating current. Consequently, persistent current tripled in amplitude. Expression of beta1 or chimeric subunits including the beta1 extracellular domain, however, favored inactivation. Coexpressing Na(V)1.1 and beta4 with beta1 produced tiny persistent currents, indicating that beta1 overcomes the effects of beta4 in heterotrimeric channels. In contrast, beta1(C121W), which contains an extracellular epilepsy-associated mutation, did not counteract the destabilization of inactivation by beta4 and also required unusually large depolarizations for channel opening. In cultured hippocampal neurons transfected with beta4, persistent current was slightly but significantly increased. Moreover, in beta4-expressing neurons from Scn1b and Scn1b/Scn2b null mice, entry into inactivated states was slowed. These data suggest that beta1 and beta4 have antagonistic roles, the former favoring inactivation, and the latter favoring activation. Because increased Na channel availability may facilitate action potential firing, these results suggest a mechanism for seizure susceptibility of both mice and humans with disrupted beta1 subunits.

  7. Study on phase equilibria in Na2 B4 O7 -NaBr-Na2 SO4 -H2O quaternary system at 348 K%Na2B4O7-NaBr-Na2SO4-H2O四元体系348K相平衡研究

    Institute of Scientific and Technical Information of China (English)

    宁慧逸; 桑世华; 王丹; 曾晓晓

    2012-01-01

    采用等温溶解平衡法研究Na2B4O7 -NaBr-Na2SO4-H2O四元体系在348 K的相平衡关系,测定了平衡液相的溶解度和密度.根据实验数据绘制相应相图.该四元体系相图中有1个共饱点E,3条单变量曲线E1E,E2E,E3E,3个结晶区的平衡固相分别为:NaBr,Na2SO4和Na2B4O7 · 5H2O.研究结果表明:该四元体系无复盐和固溶体生成,属于简单四元体系,NaBr对Na2B4O7·5H2O和Na2SO4有较强的盐析作用.并对NaBr和Na2B4O7在不同温度下含有的结晶水数进行了对比分析,简要讨论了密度变化规律.%The solubilities and densities of solution in Na2B4O7-NaBr- Na2SO4-H2O quaternary system at 348 K were determined by isothermal equilibrium method. Based on the experimental data, the equilibrium phase diagram was plotted, which consists of one invariant E, three univariant curves (E1E, E2E and E3E) , and three crystallization fields corresponding to NaBr, Na2SO4 and Na2B4O7 ? 5H2O. The experimental results indicate that the quaternary system is of simple eutectic type and no double salt and solid solution, and sodium bromide has the salting-out effect on Na2B4O7 ? 5H2O and Na2SO4. The densities transformation rules were discussed.

  8. Problematika rizikového chování u dětí na internetu

    OpenAIRE

    SKOŘEPOVÁ, Lucie

    2016-01-01

    This bachelor thesis deals with the problem of risky online behaviour of children and it focuses on cyberbullying. The theoretical part describes the risky online behaviour its definition, characterization and it also deals with prevention of the risky behaviour. The empirical part focuses on the introduction of the problem of cyberbullying in selected secondary schools in Jindřichův Hradec with which types of cyberbullying the students have already come across, what are the most common reaso...

  9. Coordinated regulation of cardiac Na(+)/Ca (2+) exchanger and Na (+)-K (+)-ATPase by phospholemman (FXYD1).

    Science.gov (United States)

    Cheung, Joseph Y; Zhang, Xue-Qian; Song, Jianliang; Gao, Erhe; Chan, Tung O; Rabinowitz, Joseph E; Koch, Walter J; Feldman, Arthur M; Wang, JuFang

    2013-01-01

    Phospholemman (PLM) is the founding member of the FXYD family of regulators of ion transport. PLM is a 72-amino acid protein consisting of the signature PFXYD motif in the extracellular N terminus, a single transmembrane (TM) domain, and a C-terminal cytoplasmic tail containing three phosphorylation sites. In the heart, PLM co-localizes and co-immunoprecipitates with Na(+)-K(+)-ATPase, Na(+)/Ca(2+) exchanger, and L-type Ca(2+) channel. The TM domain of PLM interacts with TM9 of the α-subunit of Na(+)-K(+)-ATPase, while its cytoplasmic tail interacts with two small regions (spanning residues 248-252 and 300-304) of the proximal intracellular loop of Na(+)/Ca(2+) exchanger. Under stress, catecholamine stimulation phosphorylates PLM at serine(68), resulting in relief of inhibition of Na(+)-K(+)-ATPase by decreasing K(m) for Na(+) and increasing V(max), and simultaneous inhibition of Na(+)/Ca(2+) exchanger. Enhanced Na(+)-K(+)-ATPase activity lowers intracellular Na(+), thereby minimizing Ca(2+) overload and risks of arrhythmias. Inhibition of Na(+)/Ca(2+) exchanger reduces Ca(2+) efflux, thereby preserving contractility. Thus, the coordinated actions of PLM during stress serve to minimize arrhythmogenesis and maintain inotropy. In acute cardiac ischemia and chronic heart failure, either expression or phosphorylation of PLM or both are altered. PLM regulates important ion transporters in the heart and offers a tempting target for development of drugs to treat heart failure.

  10. Renovation of Shaft Mining Building No. 2 in Kłodawa Salt Mine/ Renowacja Budynku Nadszybia Nr 2 Na Terenie Kopalni Soli "Kłodawa" S.A.

    Science.gov (United States)

    Błaszczyński, Tomasz; Wielentejczyk, Przemysław

    2015-06-01

    The paper presents the renovation process of the shaft mining building No. 2 situated in the Kłodawa Salt Mine. A technical state of the facility required immediate reinforcement of structural elements, which was confirmed by expertise carried out by the authors. A lack of repairs could be the cause of building damage. The progress of corrosion in some steel profiles of columns or floors was very advanced. The state of the building was rapidly worsening due to the very high salinity of the indoor environment, moisture (building not insulated) and vibrating engines of machinery operating on different floors felt throughout the facility. After carrying out the technical expertise, working plans and specifications, and relevant numerical analysis, the modernization process was realized by the reinforcement or rebuilding of structural elements. Referat przedstawia sposób remontu i naprawy konstrukcji nośnej i obudowy budynku nadszybia nr 2 na terenie Kopalni Soli "Kłodawa". Elementy konstrukcyjne budynku wymagały natychmiastowego wzmocnienia, co potwierdziła ekspertyza wykonana przez autorów. Zaniechanie prac remontowych groziło awarią budowlaną pomimo przeprowadzonej wcześniej w 2002 r. naprawy. Postęp korozji w niektórych profilach stalowych słupów czy stropów był bardzo zaawansowany. Stan obiektu pogarszał się szybko ze względu na bardzo duże zasolenie środowiska, wilgoć (budynek nieocieplony) oraz pracujące na poszczególnych poziomach maszyny wytwarzające duże drgania wyczuwalne w każdym miejscu obiektu. Wykonano ekspertyzę i projekt wykonawczy przed przystąpieniem do prac renowacyjnych. Przeprowadzono stosowną analizę numeryczną budynku uwzględniając w obliczeniach osłabione korozją elementy pomniejszając odpowiednio w modelu ich parametry wytrzymałościowe. Na tej podstawie zaproponowano stosowne wzmocnienia. Zastosowano technologie wzmocnień stosując wymianę profili stalowych, wspawywanie dodatkowych profili lub blach

  11. The paranodal cytoskeleton clusters Na(+) channels at nodes of Ranvier.

    Science.gov (United States)

    Amor, Veronique; Zhang, Chuansheng; Vainshtein, Anna; Zhang, Ao; Zollinger, Daniel R; Eshed-Eisenbach, Yael; Brophy, Peter J; Rasband, Matthew N; Peles, Elior

    2017-01-30

    A high density of Na(+) channels at nodes of Ranvier is necessary for rapid and efficient action potential propagation in myelinated axons. Na+ channel clustering is thought to depend on two axonal cell adhesion molecules that mediate interactions between the axon and myelinating glia at the nodal gap (i.e., NF186) and the paranodal junction (i.e., Caspr). Here we show that while Na(+) channels cluster at nodes in the absence of NF186, they fail to do so in double conditional knockout mice lacking both NF186 and the paranodal cell adhesion molecule Caspr, demonstrating that a paranodal junction-dependent mechanism can cluster Na(+) channels at nodes. Furthermore, we show that paranode-dependent clustering of nodal Na(+) channels requires axonal βII spectrin which is concentrated at paranodes. Our results reveal that the paranodal junction-dependent mechanism of Na(+)channel clustering is mediated by the spectrin-based paranodal axonal cytoskeleton.

  12. Good intentions and ICH-GCP: Trial conduct training needs to go beyond the ICH-GCP document and include the intention-to-treat principle.

    Science.gov (United States)

    Browne, Lois H; Graham, Peter H

    2014-12-01

    It is assumed investigators and statisticians fully understand the importance of avoiding missing outcomes and the intention-to-treat principle during design and analysis phases of a randomised controlled trial in order to obtain the most valuable and reliable results. However, many personnel undertaking day-to-day trial conduct and data collection commonly rely exclusively for guidance on the widely implemented, indeed regulated, International Conference on Harmonisation-Good Clinical Practice document as the guideline and standard for trial conduct. This article describes adverse consequences of omission of intention-to-treat principles from training for trial personnel and explores the need for training in addition to the International Conference on Harmonisation-Good Clinical Practice guideline document. Data from the Breast Boost Study were used to illustrate a comparison of actual results, where vigilant senior investigators re-enforced intention-to-treat requirements throughout all aspects of trial conduct with results that could easily have occurred if study personnel did not understand the importance of intention-to-treat principles. Experience as a co-ordinating centre for an international trial (Trans-Tasman Radiation Oncology Group 08.06 Breast STARS) acted as an audit of data-management culture regarding intention-to-treat in Australia and New Zealand. Despite the Breast Boost Study exceeding planned accrual, it was demonstrated that the study, which found a statistically significant result, could have reported a negative or inconclusive result under the scenario of trial conduct personnel having lack of understanding of the importance of avoiding losses to follow-up. Trans-Tasman Radiation Oncology 08.06 co-ordination experience verified that data-management culture in Australia and New Zealand does not adequately recognise intention-to-treat principles, and this is reflected in trial conduct. Trial data described are limited to two trials and in the Australian and New Zealand setting. To be both scientifically and ethically valid, guidelines for trial conduct should include and stress the importance of the intention-to-treat principle and in particular avoiding missing outcomes. Our discussion highlights the vitally important role played by personnel involved in day-to-day trial conduct. Inclusion of scientific principles in guideline documents and/or training which goes beyond International Conference on Harmonisation-Good Clinical Practice to include intention-to-treat is essential to achieve robust research results. Related aspects of randomised trial consent and ethics are discussed. © The Author(s) 2014.

  13. Sociologia na complexidade Sociology in complexity

    Directory of Open Access Journals (Sweden)

    Gilson Lima

    2006-06-01

    Full Text Available O artigo se propõe a fazer uma introdução didática e informativa e, ao mesmo tempo, aprofundada sobre as conseqüências da emergência do paradigma da complexidade para a Sociologia. No desenrolar da narrativa, faz comparações, o que permite ao leitor não familiarizado com a temática da ciência identificar as diferenças macroparadigmáticas pré-modernas, da modernidade simples e da emergência do paradigma da complexidade. Define e exemplifica, sempre que possível, os termos, afirmações e princípios significativos para uma melhor compreensão do tema. Faz, também, inúmeras indicações, no interior da narrativa, de autores e obras, para que aqueles que desejarem continuar, possam mergulhar mais intensamente nos caminhos da sociologia da complexidade. O artigo inicia com uma introdução que define, a partir de Thomas Kuhn, o conceito de paradigma. A seguir, desenvolve de modo comparado, os princípios mais importantes do paradigma da complexidade. E, por fim, chama a atenção para alguns desafios da Sociologia na complexidade, alertando para os riscos da paralisação da complexidade na difícil tarefa de religarmos os saberes diante da hiperespecialização presente na crise do paradigma da modernidade simples.The article is a simultaneously didactic and informative deep introduction on the emergence of the paradigm of complexity for sociology. Along the narrative, we make comparisons, which allows the reader who is not familiar with the themes of science to identify the macro-paradigmatic pre-modern differences from simple modernity and the emergence of the paradigm of complexity. Whenever it is possible, we define and exemplify the terms, assertions, and principles that are significant for an understanding of the theme. We have also made numerous indications of authors and works within the narrative, thus those willing might take a deeper dive in the pathways of sociology of complexity. The article starts with an

  14. Mazungumzo na Adam Shafi juu ya uandishi wake wa riwaya

    OpenAIRE

    Diegner, Lutz; Shafi, Adam

    2012-01-01

    Adam Shafi aliyezaliwa mwaka 1940 kisiwani Unguja ni mmojawapo wa waandishi mashuhuri wa riwaya ya Kiswahili. Hivi sasa mwandishi yumo mbioni kukamilisha muswada wa riwaya yake ya sita iitwayo Mtoto wa Mama. Mbali na uandishi, Adam Shafi aliwahi kufanya kazi mbalimbali za uandishi wa habari na kazi za ushirika wa kimataifa. Ni furaha yetu kubwa kuwa hatimaye tunaweza kutoa mazungumzo hayo baada ya kuyapitia na kuyahariri kidogo tu, kwa vile tunaamini utamu wa lugha inavyozungumzwa katika hali...

  15. Neutron diffraction studies of the Na-ion battery electrode materials NaCoCr2(PO4)3, NaNiCr2(PO4)3, and Na2Ni2Cr(PO4)3

    Science.gov (United States)

    Yahia, H. Ben; Essehli, R.; Avdeev, M.; Park, J.-B.; Sun, Y.-K.; Al-Maadeed, M. A.; Belharouak, I.

    2016-06-01

    The new compounds NaCoCr2(PO4)3, NaNiCr2(PO4)3, and Na2Ni2Cr(PO4)3 were synthesized by sol-gel method and their crystal structures were determined by using neutron powder diffraction data. These compounds were characterized by galvanometric cycling and cyclic voltammetry. NaCoCr2(PO4)3, NaNiCr2(PO4)3, and Na2Ni2Cr(PO4)3 crystallize with a stuffed α-CrPO4-type structure. The structure consists of a 3D-framework made of octahedra and tetrahedra that are sharing corners and/or edges generating channels along [100] and [010], in which the sodium atoms are located. Of significance, in the structures of NaNiCr2(PO4)3, and Na2Ni2Cr(PO4)3 a statistical disorder Ni2+/Cr3+ was observed on both the 8g and 4a atomic positions, whereas in NaCoCr2(PO4)3 the statistical disorder Co2+/Cr3+ was only observed on the 8g atomic position. When tested as negative electrode materials, NaCoCr2(PO4)3, NaNiCr2(PO4)3, and Na2Ni2Cr(PO4)3 delivered specific capacities of 352, 385, and 368 mA h g-1, respectively, which attests to the electrochemical activity of sodium in these compounds.

  16. Simulation of Na D emission near Europa during eclipse

    Science.gov (United States)

    Cassidy, T.A.; Johnson, R.E.; Geissler, P.E.; Leblanc, F.

    2008-01-01

    The Cassini imaging science subsystem observed Europa in eclipse during Cassini's Jupiter flyby. The disk-resolved observations revealed a spatially nonuniform emission in the wavelength range of 200-1050 nm (clear filters). By building on observations and simulations of Europa's Na atmosphere and torus we find that electron-excited Na in Europa's tenuous atmosphere can account for the observed emission if the Na is ejected preferentially from Europa's dark terrain. Copyright 2008 by the American Geophysical Union.

  17. 三元体系NaBr-Na2SO4-H2O 和 NaBr-KBr-H2O 373 K相平衡%Phase Equilibria of Two Ternary Systems NaBr-Na2SO4-H2O and NaBr-KBr-H2O at 373 K

    Institute of Scientific and Technical Information of China (English)

    桑世华; 崔瑞芝; 胡咏霞

    2014-01-01

    针对川西盆地富硼钾溴地下卤水组成,采用等温溶解平衡法研究了三元体系 NaBr-Na2SO4-H2O 和NaBr-KBr-H2O在373 K时的相平衡,测定了373 K条件下平衡溶液的溶解度和密度,根据实验数据绘制相应的相图和密度图。研究发现:两个三元体系在373 K条件下均属于简单共饱和型,无复盐及固溶体生成。相图中均有一个共饱和点,2个平衡固相结晶区和2条单变量曲线。在三元体系NaBr-Na2SO4-H2O中,平衡固相分别为:NaBr和Na2SO4,三元体系NaBr-KBr-H2O相应的平衡固相分别为:NaBr和KBr。并简单讨论了密度的变化规律。%Phase equilibria of two ternary systems NaBr-Na2SO4-H2O and NaBr-KBr-H2O at 373 K were studied by an isothermal solution saturation method. The solubility and density of these systems were determined experimentally and related phase diagrams were obtained. The results show that the two systems are both of simple type with no complex salts or solid solutions formed. Both of the phase diagrams show that they have one eutectic point, two univariant curves and two regions of crystallization. The solid phase in NaBr-Na2SO4-H2O is cpmposited of sodium bromide(NaBr) and sodium sulfate(Na2SO4), while sodium bromide(NaBr) and potassium bromide(KBr) are the components of the solid phase of NaBr-KBr-H2O. Density change of the two systems was discussed.

  18. Inseminación artificial na vaca

    OpenAIRE

    Becerra González, Juan J.

    2011-01-01

    A Obstetricia e Reprodución (131504) é unha materia que se imparte no quinto curso da licenciatura en Veterinaria. Non existen requisitos previos legais e calquera alumno matriculado na licenciatura en Veterinaria pode cursar esta materia. Porén, é conveniente que o alumnado teña coñecementos previos de anatomía e fisioloxía veterinaria, así como de patoloxía xeral e propedeútica clínica. Tamén sería aconsellable que os estudantes teñan coñecementos básicos de TICs, xa que serán de...

  19. The NA49 large acceptance hadron detector

    CERN Document Server

    Afanasiev, S V; Appelshäuser, H; Bächler, J; Barna, D; Barnby, L S; Bartke, Jerzy; Barton, R A; Betev, L; Bialkowska, H; Bieser, F; Billmeier, A; Blyth, C O; Böck, R K; Bormann, C; Bracinik, J; Brady, F P; Brockmann, R; Brun, R; Buncic, P; Caines, H L; Cebra, D; Cooper, G E; Cramer, J G; Csató, P; Cyprian, M; Dunn, J; Eckardt, V; Eckhardt, F; Empl, T; Eschke, J; Ferguson, M I; Fessler, H; Fischer, H G; Flierl, D; Fodor, Z; Frankenfeld, Ulrich; Foka, P Y; Freund, P; Friese, V; Ftácnik, J; Fuchs, M; Gabler, F; Gál, J; Ganz, R E; Gazdzicki, M; Gladysz-Dziadus, E; Grebieszkow, J; Günther, J; Harris, J W; Hegyi, S; Henkel, T; Hill, L A; Hlinka, V; Huang, I; Hümmler, H; Igo, G; Irmscher, D; Ivanov, M; Janik, R; Jacobs, P; Jones, P G; Kadija, K; Kolesnikov, V I; Kowalski, M; Lasiuk, B; Lévai, Peter; Liebicher, K; Lynen, U; Malakhov, A I; Margetis, S; Markert, C; Marks, C; Mayes, B W; Melkumov, G L; Mock, A; Molnár, J; Nelson, J M; Oldenburg, M; Odyniec, Grazyna Janina; Pálla, G; Panagiotou, A D; Pestov, Yu N; Petridis, A; Pikna, M; Pimpl, W; Pinsky, L; Piper, A; Porter, R J; Poskanzer, A M; Poziombka, S; Prindle, D J; Pühlhofer, F; Rauch, W; Reid, J G; Renfordt, R E; Retyk, W; Ritter, H G; Röhrich, D; Roland, C; Roland, G; Rudolph, H; Rybicki, A; Sammer, T; Sandoval, A; Sann, H; Schäfer, E; Schmidt, R; Schmischke, D; Schmitz, N; Schönfelder, S; Semenov, A Yu; Seyboth, J; Seyboth, P; Seyerlein, J; Siklér, F; Sitár, B; Skrzypczak, E; Squier, G T A; Stelzer, H; Stock, Reinhard; Strmen, P; Ströbele, H; Struck, C; Susa, T; Szarka, I; Szentpétery, I; Szymanski, P; Sziklai, J; Toy, M; Trainor, T A; Trentalange, S; Ullrich, T S; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wang, F; Weerasundara, D D; Wenig, S; Whitten, C; Wieman, H H; Wienold, T; Wood, L; Yates, T A; Zimányi, J; Zhu, X Z; Zybert, R

    1999-01-01

    The NA49 detector is a wide acceptance spectrometer for the study of hadron production in p+p, p+A, and A+A collisions at the CERN SPS. The main components are 4 large volume TPCs for tracking and particle identification via $dE/dx$. TOF scintillator arrays complement particle identification. Calorimeters for transverse energy determination and triggering, a detector for centrality selection in p+A collisions, and beam definition detectors complete the set-up. A description of all detector components is given with emphasis on new technical realizations. Performance and operational experience are discussed in particular with respect to the high track density environment of central Pb+Pb collisions.

  20. Natureza e economia na teoria freudiana

    OpenAIRE

    Furlan,Reinaldo

    2000-01-01

    O objetivo deste artigo é apontar, em primeiro lugar, para a importância das noções de "força" e de "natureza" na obra freudiana e suas implicações para a cultura e a moral. De modo geral, apontar para a importância da Biologia no processo civilizatório, tanto à respeito das prerrogativas da espécie quanto do indivíduo. Em segundo lugar, apontar para a mudança ocorrida nessas questões com a introdução do conceito de "Eros". Privilegiamos a apresentação de dois textos para nosso propósito: o "...

  1. Viva o Rock: vivenciando saberes na musicalidade

    OpenAIRE

    Mosca, Maristela de Oliveira

    2011-01-01

    Este trabalho parte da narrativa de um Projeto Musicalizador que tem como foco a construção de um espetáculo musical na Escola de Educação Básica. Neste recorte refletimos epistemologicamente sob as luzes dos Sete Saberes Necessários à Educação do Futuro, em uma interligação com os cenários dos Quatro Pilares da Educação – aprender a conhecer, aprender a fazer, aprender a viver juntos, aprender a ser, e as concepções pedagógicas do Orff-Schulwerk. A interlocução com os Pressupostos da Corpore...

  2. O operar de um coletivo na web

    Directory of Open Access Journals (Sweden)

    Karen Eidelwein

    Full Text Available Analisamos o operar de um grupo de discussão na WEB buscando identificar seu agenciamento enquanto coletivo autoprodutivo. Estabelecemos sete indicadores de operação e cinco categorias temáticas. A visualização de cada um dos indicadores de operação em cada uma das categorias temáticas possibilitou compreender o operar do grupo como decorrente das próprias relações que foram sendo estabelecidas, em um processo autoprodutivo, de causalidade recursiva. Foi possível argumentar que o grupo apresentou indícios de um modo de instituir-se capaz de apontar para outras formas de relação em torno da construção de objetos coletivos teóricos voltados para a ação fora do espaço digital.

  3. O operar de um coletivo na WEB

    Directory of Open Access Journals (Sweden)

    Karen Eidelwein

    Full Text Available Analisamos o operar de um grupo de discussão na WEB buscando identificar seu agenciamento enquanto coletivo autoprodutivo. Estabelecemos sete indicadores de operação e cinco categorias temáticas. A visualização de cada um dos indicadores de operação em cada uma das categorias temáticas possibilitou compreender o operar do grupo como decorrente das próprias relações que foram sendo estabelecidas, em um processo autoprodutivo, de causalidade recursiva. Foi possível argumentar que o grupo apresentou indícios de um modo de instituir-se capaz de apontar para outras formas de relação em torno da construção de objetos coletivos teóricos voltados para a ação fora do espaço digital.

  4. SORPCJA CHROMU (VI NA MODYFIKOWANYCH ZEOLITACH NATURALNYCH

    Directory of Open Access Journals (Sweden)

    Paulina SOBOLEWSKA

    Full Text Available Celem badań było wyznaczenie równowagi sorpcji jonów chromu (VI z roztworów wodnych na modyfikowanych zeolitach naturalnych pochodzących z Włoch i USA. Do syntezy organo-zeolitów zastosowano HDTMA-Br w ilości dwukrotnej pojemności kationowymiennej zeolitów (2,0 ECEC. Badania przeprowadzono w warunkach nieprzepływowych przy odczynie pH równym 3,0; 4,0 i 5,0 w temperaturze pokojowej. Największą efektywność sorpcji jonów Cr(VI uzyskano dla chabazytu przy pH=4 i uziarnienia poniżej 0,25 mm, kiedy w roztworze dominowały jony wodorochromianowe HCrO4-.

  5. UTJECAJ PROMJENJIVE POSLOVNE OKOLINE NA VRSTE RIZIKA

    OpenAIRE

    Jakaša, Tina; Bratić, Diana; Iliopoulos, Fivos

    2009-01-01

    Promjene u poslovnom okruženju uvele su novi tip rizika u poduzeća elektroprivrede. Zbog toga je za poduzeća elektroprivrede vrlo važno identificirati rizike i naći korelaciju među njima, te to činiti redovito kako bi se zaštitile i povećale vrijednost kompanije. U ovom se radu predlažu sljedeće tri hipoteze: H1 Postoje promjene u tipu rizika u poduzećima elektroprivrede tijekom zadnjih 10 godina. H2 Postoji korelacija između intenziteta tržišne konkurencije i utjecaja prisutnih/postojećih ti...

  6. Na-Zn liquid metal battery

    Science.gov (United States)

    Xu, Junli; Kjos, Ole Sigmund; Osen, Karen Sende; Martinez, Ana Maria; Kongstein, Ole Edvard; Haarberg, Geir Martin

    2016-11-01

    A new kind of membrane free liquid metal battery was developed. The battery employs liquid sodium and zinc as electrodes both in liquid state, and NaCl-CaCl2 molten salts as electrolyte. The discharge flat voltage is in the range of about 1.4 V-1.8 V, and the cycle efficiency achieved is about 90% at low discharge current densities (below 40 mA cm-2). Moreover, this battery can also be charged and discharged at high current density with good performance. The discharge flat voltage is above 1.1 V when it is discharged at 100 mA cm-2, while it is about 0.8 V with 100% cycle efficiency when it is discharged at 200 mA cm-2. Compared to other reported liquid metal battery, this battery has lower cost, which suggests broad application prospect in energy storage systems for power grid.

  7. Violência na Terceira Idade

    OpenAIRE

    Vale, Soraia Domingues

    2014-01-01

    Projecto de Graduação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Licenciada em Criminologia No presente projeto, cujo tema é violência sobre os idosos, irão ser definidos, no Capítulo I, conceitos como envelhecimento, violência, tipos de violência, as características das vítimas e dos agressores, fatores de risco e de prevenção e o “estado da arte” sobre o fenómeno da violência na terceira idade. No Capítulo II, são abordados os locais ...

  8. The NA49 large acceptance hadron detector

    Energy Technology Data Exchange (ETDEWEB)

    Afanasiev, S.; Alber, T.; Appelshaeuser, H.; Baechler, J.; Barna, D.; Barnby, L.S.; Bartke, J.; Barton, R.A.; Betev, L.; Bialkowska, H.; Bieser, F.; Billmeier, A.; Blyth, C.O.; Bock, R.; Bormann, C.; Bracinik, J.; Brady, F.P.; Brockmann, R.; Brun, R.; Buncic, P.; Caines, H.L.; Cebra, D.; Cooper, G.E.; Cramer, J.G.; Csato, P.; Cyprian, M.; Dunn, J.; Eckardt, V.; Eckhardt, F.; Empl, T.; Eschke, J.; Ferguson, M.I.; Fessler, H.; Fischer, H.G.; Flierl, D.; Fodor, Z.; Frankenfeld, U.; Foka, P.; Freund, P.; Friese, V.; Ftacnik, J.; Fuchs, M.; Gabler, F.; Gal, J.; Ganz, R.; Gazdzicki, M.; Gladysz, E.; Grebieszkow, J.; Guenther, J.; Harris, J.W.; Hegyi, S.; Henkel, T.; Hill, L.A.; Hlinka, V.; Huang, I.; Huemmler, H.; Igo, G.; Irmscher, D.; Ivanov, M.; Janik, R.; Jacobs, P.; Jones, P.G.; Kadija, K.; Kolesnikov, V.I.; Kowalski, M.; Lasiuk, B.; Levai, P.; Liebicher, K.; Lynen, U.; Malakhov, A.I.; Margetis, S.; Markert, C.; Marks, C.; Mayes, B.; Melkumov, G.L.; Mock, A.; Molnar, J.; Nelson, J.M.; Oldenburg, M.; Odyniec, G.; Palla, G.; Panagiotou, A.D.; Pestov, Y.; Petridis, A.; Pikna, M.; Pimpl, W.; Pinsky, L.; Piper, A.; Porter, R.J.; Poskanzer, A.M.; Poziombka, S.; Prindle, D.J.; Puehlhofer, F.; Rauch, W.; Reid, J.G.; Renfordt, R.; Retyk, W.; Ritter, H.G.; Roehrich, D.; Roland, C.; Roland, G.; Rudolph, H.; Rybicki, A.; Sammer, T.; Sandoval, A.; Sann, H.; Schaefer, E.; Schmidt, R.; Schmischke, D.; Schmitz, N.; Schoenfelder, S.; Semenov, A.Yu.; Seyboth, J.; Seyboth, P.; Seyerlein, J.; Sikler, F.; Sitar, B.; Skrzypczak, E.; Squier, G.T.A.; Stelzer, H.; Stock, R.; Strmen, P.; Stroebele, H.; Struck, C.; Susa, T.; Szarka, I.; Szentpetery, I.; Szymanski, P.; Sziklai, J.; Toy, M.; Trainor, T.A.; Trentalange, S.; Ullrich, T.; Vassiliou, M.; Veres, G.; Vesztergombi, G.; Vranic, D.; Wang, F.Q.; Weerasundara, D.D.; Wenig, S. E-mail: siegfried.wenig@cern.ch; Whitten, C.; Wieman, H.; Wienold, T.; Wood, L.; Yates, T.A.; Zimanyi, J.; Zhu, X.-Z.; Zybert, R

    1999-07-01

    The NA49 detector is a wide acceptance spectrometer for the study of hadron production in p+p, p+A, and A+A collisions at the CERN SPS. The main components are 4 large-volume TPCs for tracking and particle identification via dE/dx. TOF scintillator arrays complement particle identification. Calorimeters for transverse energy determination and triggering, a detector for centrality selection in p+A collisions, and beam definition detectors complete the set-up. A description of all detector components is given with emphasis on new technical realizations. Performance and operational experience are discussed in particular with respect to the high track density environment of central Pb+Pb collisions.

  9. LUZ, MELATONINA E ESTRESSE OXIDATIVO NA PISCICULTURA

    OpenAIRE

    2013-01-01

    Em peixes, como nos mamíferos, partes do sistema nervoso estão envolvidas em mecanismos para regulação dos sistemas corporais em sintonia com o meio. O fotoperíodo é traduzido em informações fisiológicas a partir da secreção de melatonina.Parece não haver barreiras morfofisiológicas para esta indolamina, isto é, a melatonina perfunde-se rapidamente em cada célula do organismo e em alguns casos interage com receptores e membrana situados na superfície celular, e parece estar ligada à ingestão ...

  10. O retorno do religioso na contemporaneidade

    Directory of Open Access Journals (Sweden)

    Tiago Ribeiro Nunes

    2008-12-01

    Full Text Available O presente trabalho pretende analisar os novos modos de relação, entre a civilização e o sagrado, que emergem no contexto da contemporaneidade. Partindo principalmente das formulações freudianas e lacanianas sobre o tema, nosso objetivo primordial ao longo deste artigo é estabelecer parâmetros para compreender a ocorrência do "retorno ao sagrado no exato momento em que a humanidade enfrenta crises cada vez mais profundas e permanentes. Tal empreendimento nos permitirá verificar até que ponto o fortalecimento dos movimentos religiosos pode ser considerado como uma das conseqüências da queda dos referenciais que se realiza na contemporaneidade.

  11. Bullying: ato esburacado na angústia

    Directory of Open Access Journals (Sweden)

    Maria de Lourdes Soares Ornellas

    2012-04-01

    Full Text Available A noção de afeto está no campo do (desprazer, resultante de uma experiência afetiva de satisfação ou insatisfação, e que se manifesta nas necessidades do sujeito. Pode-se dizer que o afeto envolve a ambivalência de sentimentos, do mais agradável ao mais insuportável, e desempenha um papel estruturante para que o sujeito reencontre sua estrutura psíquica, exercendo uma ação mediadora e decisiva sobre a constituição do sujeito do desejo, orientando o seu projeto de vida, sua profissão, sua opção sexual, etc. Essa ambivalência de afetos deve ser exercitada na educação familiar e escolar, na fala e na escuta que o afeto (desprazeroso tem relevância e parece ser silenciado. O desprazer pode ser escandido pelos sintomas medo, depressão, irritabilidade, ansiedade, humilhação. Assim posto o bullying é também conhecido como a síndrome da humilhação. O objetivo da humilhação é a tentativa de destruição do sujeito; a perda da identificação revela um fantasma, na medida em que própria vítima se sente culpada por sofrer ou por estar sofrendo um ato esburacado porque uma das peças não é encontrada e, em lugar do encaixe, o que se mostra é um buraco, o que provoca a angústia entre quem perde e aquele que ganha. ABSTRACT: The notion of affect is thus in the field of (dis pleasure, resulting from an affective experience of satisfaction or dissatisfaction, and that manifests itself on the needs of the subject. You could say that the affection involves the ambivalence of feelings, the more enjoyable the more unbearable, and plays a structural role for the subject to rediscover his psychic structure, exerting a mediator and decisive action on the constitution of the subject of desire, directing the its design life, your profession, your sexual orientation, etc.. This ambivalence of feelings should be exercised in family education and school, talking and listening that affect (dis pleasure is relevant and appears to be

  12. 蚕豆幼苗对NaCl和NaHCO3胁迫的生理响应%Physiological responses of Viciafaba L.seedlings under NaCl and NaHCO3 stress

    Institute of Scientific and Technical Information of China (English)

    乔枫; 罗桂花; 耿贵工

    2011-01-01

    Vicia faba L. Seedlings were treated with different concentrations of NaCl and NaHCO3 for 7 days,and the fresh weight, malondialdehyde (MDA) content, free proline content, and the activities of antioxidant enzymes were determined. The results were as follows. With the increase of NaCl and NaHCO3 concentrations, fresh weight of Vicia faba L. Seedlings first increased significantly and then declined, MDA and free proline contents increased significantly, and the increase extent under NaCl stress was lower than under NaHCO3. The activity of superoxide dismutase ( SOD) first increased significantly and then declined. The activity of peroxidase ( POD) increased significantly under NaCl stress, and first rose and then decreased significantly under NaHCO3 stress.The activity of catalase (CAT) increased significantly. In conclusion, Vicia faba L. Could resist salt and alkali stress to a certain degree. The responses of Vicia faba L. To alkali stress were more obvious than that to salt stress on average.%采用不同浓度的NaCl和NaHCO3处理蚕豆幼苗,处理7d后分别测定蚕豆幼苗鲜重、蚕豆叶片MDA和脯氨酸含量、蚕豆叶片抗氧化酶活性.结果显示,随NaCl和NaHCO3胁迫浓度的增加,蚕豆幼苗鲜重先显著增加后显著下降(P<0.05);叶中MDA和脯氨酸含量显著上升(P<0.05),NaCl低于NaHCO3的上升幅度;超氧化物歧化酶(SOD)活性先显著增加(P<0.05)然后下降;过氧化物酶(POD)活性在NaCl胁迫下显著升高(P<0.05),NaHCO3胁迫下先升高后显著降低(P<0.05);过氧化氢酶(CAT)活性显著增加(P<0.05).蚕豆具有一定程度的抗盐碱性,碱胁迫大于同浓度盐胁迫的伤害.

  13. NaCl胁迫对阿月浑子各器官Na+、K+吸收的影响%Effect of NaCl Stress on Na+ and K+ Uptakes by Different Organs of Pistachio

    Institute of Scientific and Technical Information of China (English)

    克热木·伊力; 袁琳; 马合木提·卡热

    2005-01-01

    在温室盆栽条件下,用NaCl处理新疆长果阿月浑子与美国品种Kerman,处理浓度为50、150、250和500 mmol·L-1,盐处理后5、10、20 d分别取叶、茎和根,测定各器官中Na+、K+含量及Na+/K+变化规律.研究结果表明,随着土壤盐浓度的增加,长果阿月浑子和Kerman的叶、茎和根中Na+离子含量在盐处理5、10、20 d后每个处理都表现出升高趋势;而两个品种的叶、根和茎中的K+含量在盐处理后其变化规律都不稳定.长果阿月浑子叶片、茎和根系中Na+/K+的比值在盐处理5 d和10 d都升高.Kerman的叶和根系中Na+/K+比值在处理5、10、20 d后升高;茎中Na+/K+处理10 d后升高,但20 d后没有明显变化.实验结果表明NaCl胁迫后,长果阿月浑子的叶片中Na+含量增加幅度均大于Kerman,Kerman根和茎中的Na+含量增加幅度大于长果阿月浑子;NaCl胁迫5 d和10 d后,长果阿月浑子叶片中的Na+/K+的比值高于Kerman,Kerman茎和根部中的Na+/K+的比值高于长果阿月浑子,表明了长果阿月浑子和Kerman都具有一定的耐盐性,但Kerman的耐盐性强于长果阿月浑子.由于叶片和根中Na+和Na+/K+比值的变化很稳定,可以确定为阿月浑子主要抗盐指标,茎中Na+/K+的变化规律较稳定,可以作为抗盐性参考指标.

  14. Analiza preiskovalnih metod na primeru igre Scotland Yard

    OpenAIRE

    BELEJ, NEŽA

    2015-01-01

    V diplomskem delu se seznanimo s področjem umetne inteligence, ki se ukvarja z raziskovanjem namiznih iger in iskanjem njihovih programskih rešitev. Preučimo algoritem drevesnega preiskovanja Monte-Carlo in ga poskušamo čim bolj spretno prenesti na znano namizno igro Scotland Yard, pri čemer upoštevamo nasvete Nijssena in Winandsa. Osredotočimo se predvsem na tretjo fazo algoritma, simulacijo, katero se odločimo implementirati na tri različne načine (od manj naprednih do bolj naprednih), te n...

  15. Kaolin-based geopolymers with various NaOH concentrations

    Science.gov (United States)

    Heah, C. Y.; Kamarudin, H.; Mustafa Al Bakri, A. M.; Bnhussain, M.; Luqman, M.; Khairul Nizar, I.; Ruzaidi, C. M.; Liew, Y. M.

    2013-03-01

    Kaolin geopolymers were produced by the alkali-activation of kaolin with an activator solution (a mixture of NaOH and sodium silicate solutions). The NaOH solution was prepared at a concentration of 6-14 mol/L and was mixed with the sodium silicate solution at a Na2SiO3/NaOH mass ratio of 0.24 to prepare an activator solution. The kaolin-to-activator solution mass ratio used was 0.80. This paper aimed to analyze the effect of NaOH concentration on the compressive strength of kaolin geopolymers at 80°C for 1, 2, and 3 d. Kaolin geopolymers were stable in water, and strength results showed that the kaolin binder had adequate compressive strength with 12 mol/L of NaOH concentration. When the NaOH concentration increased, the SiO2/Na2O decreased. The increased Na2O content enhanced the dissolution of kaolin as shown in X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) analyses. However, excess in this content was not beneficial for the strength development of kaolin geopolymers. In addition, there was the formation of more geopolymeric gel in 12 mol/L samples. The XRD pattern of the samples showed a higher amorphous content and a more geopolymer bonding existed as proved by FTIR analysis.

  16. Movimento fenomenologico: controversias e perspectivas na pesquisa psicologica

    National Research Council Canada - National Science Library

    Gomes de Castro, Thiago; Barbosa Gomes, William

    2011-01-01

    A repercussao do movimento fenomenologico na historia da psicologia pode ser notada pelas persistentes tentativas de transposicao do carater eidetico da fenomenologia para a analise sistematica de empiria...

  17. DISKRIMINACIJA PRI ZAPOSLOVANJU IN DELU NA PODLAGI SPOLNE USMERJENOSTI

    OpenAIRE

    Markovič, Polona

    2012-01-01

    Ustavno zagotovljena pravica do enakosti, brez kakršnegakoli razlikovanja na podlagi osebnih okoliščin, predstavlja eno izmed temeljnih človekovih pravic. Za zagotavljanje enakega obravnavanja posameznikov in različnih skupin oseb na vseh področjih družbenega življenja je neizogibno potrebna natančna zakonska opredelitev varstva pred diskriminacijo. Prepoved diskriminacije je pravno regulirana v določilih mnogih dokumentov, sprejetih na mednarodni in nacionalni ravni. Diskriminacijo lahko naj...

  18. Study of thermal neutron capture in /sup 23/Na

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Ming; Shi Zongren; Zeng Xiantang; Li Guohua; Ding Dazhao

    1987-11-01

    Energies and intensities of 117 gamma-rays produced by the capture of thermal neutron in /sup 23/Na are measured by using a single Ge(Li) detector and a pair spectrometer. 107 gamma-rays are placed in the decay scheme consisting of 35 levels. The neutron binding energy is found to be 6959.51 (21) keV. The parameters of /sup 24/Na energy level density are determined with the Back-Shift Fermi Gas Model. The /sup 23/Na(n, ..gamma..)/sup 24/Na reaction is mainly a statistical process from the resonance capture of 2.85 keV state.

  19. Study of thermal neutron capture in /sup 23/Na

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Ming; Shi Zongren; Zeng Xiantang; Li Guohua; Ding Dazhao

    1989-04-01

    Energies and intensities of 117 gamma-rays produced by the capture of thermal neutrons in /sup 23/Na are measured by using a single Ge(Li) detector and a pair spectrometer. 107 gamma-rays are placed in a decay scheme consisting of 35 levels. The neutron binding energy is found to be 6959.51 (21) keV. The parameters of /sup 24/Na energy-level density are determined with the Back-Shift Fermi Gas Model. The /sup 23/Na(/ital n/,..gamma..) /sup 24/Na reaction is mainly a statistical process from the resonance capture of the 2.85 keV state.

  20. Pragmatična lingvistika I kontrastivne študije

    Directory of Open Access Journals (Sweden)

    Josip Jernej

    1991-12-01

    Full Text Available Nakon teoretskog uvoda analiziraju se u članku pragmatična značenja nekih često upotrebljenih "čestica" kao što su samo, lijepo, već, inače, i to tragom temeljnje rasprave Pavla Tekavčića iz god. 1989. Dodani su i njemački prijevodi hrvatskim primjerima što su u spomenutoj raspravi prevedeni na talijanski. Članak završava napomenama koji se odnose na inače zapostavljenu kategoriju uzvika i njihova moguća pragmatična značenja.

  1. Transcriptional regulators of Na, K-ATPase subunits

    Directory of Open Access Journals (Sweden)

    Zhiqin eLi

    2015-10-01

    Full Text Available The Na,K-ATPase classically serves as an ion pump creating an electrochemical gradient across the plasma membrane that is essential for transepithelial transport, nutrient uptake and membrane potential. In addition, Na,K-ATPase also functions as a receptor, a signal transducer and a cell adhesion molecule. With such diverse roles, it is understandable that the Na,K-ATPase subunits, the catalytic alpha-subunit, the beta-subunit and the FXYD proteins, are controlled extensively during development and to accommodate physiological needs. The spatial and temporal expression of Na,K-ATPase is partially regulated at the transcriptional level. Numerous transcription factors, hormones, growth factors, lipids and extracellular stimuli modulate the transcription of the Na,K-ATPase subunits. Moreover, epigenetic mechanisms also contribute to the regulation of Na,K-ATPase expression. With the ever growing knowledge about diseases associated with the malfunction of Na,K-ATPase, this review aims at summarizing the best-characterized transcription regulators that modulate Na,K-ATPase subunit levels. As abnormal expression of Na,K-ATPase subunits have been observed in many carcinoma, we will also discuss transcription factors that are associated with epithelial-to-mesenchymal transition, a crucial step in the progression of many tumors to malignant disease.

  2. Mercury's Na Exosphere from MESSENGER Data

    Science.gov (United States)

    Killen, Rosemary M.; Burger, M. H.; Cassidy, T. A.; Sarantos, M.; Vervack, R. J.; McClintock, W. El; Merkel, A. W.; Sprague, A. L.; Solomon, S. C.

    2012-01-01

    MESSENGER entered orbit about Mercury on March 18, 2011. Since then, the Ultraviolet and Visible Spectrometer (UWS) channel of MESSENGER's Mercury Atmospheric and Surface Composition Spectrometer (MASCS) has been observing Mercury's exosphere nearly continuously. Daily measurements of Na brightness were fitted with non-uniform exospheric models. With Monte Carlo sampling we traced the trajectories of a representative number of test particles, generally one million per run per source process, until photoionization, escape from the gravitational well, or permanent sticking at the surface removed the atom from the simulation. Atoms were assumed to partially thermally accommodate on each encounter with the surface with accommodation coefficient 0.25. Runs for different assumed source processes are run separately, scaled and co-added. Once these model results were saved onto a 3D grid, we ran lines of sight from the MESSENGER spacecraft :0 infinity using the SPICE kernels and we computed brightness integrals. Note that only particles that contribute to the measurement can be constrained with our method. Atoms and molecules produced on the nightside must escape the shadow in order to scatter light if the excitation process is resonant-light scattering, as assumed here. The aggregate distribution of Na atoms fits a 1200 K gas, with a PSD distribution, along with a hotter component. Our models constrain the hot component, assumed to be impact vaporization, to be emitted with a 2500 K Maxwellian. Most orbits show a dawnside enhancement in the hot component broadly spread over the leading hemisphere. However, on some dates there is no dawn/dusk asymmetry. The portion of the hot/cold source appears to be highly variable.

  3. Mercury's Na Exosphere from MESSENGER Data

    Science.gov (United States)

    Killen, Rosemary M.; Burger, M. H.; Cassidy, T. A.; Sarantos, M.; Vervack, R. J.; McClintock, W. El; Merkel, A. W.; Sprague, A. L.; Solomon, S. C.

    2012-01-01

    MESSENGER entered orbit about Mercury on March 18, 2011. Since then, the Ultraviolet and Visible Spectrometer (UWS) channel of MESSENGER's Mercury Atmospheric and Surface Composition Spectrometer (MASCS) has been observing Mercury's exosphere nearly continuously. Daily measurements of Na brightness were fitted with non-uniform exospheric models. With Monte Carlo sampling we traced the trajectories of a representative number of test particles, generally one million per run per source process, until photoionization, escape from the gravitational well, or permanent sticking at the surface removed the atom from the simulation. Atoms were assumed to partially thermally accommodate on each encounter with the surface with accommodation coefficient 0.25. Runs for different assumed source processes are run separately, scaled and co-added. Once these model results were saved onto a 3D grid, we ran lines of sight from the MESSENGER spacecraft :0 infinity using the SPICE kernels and we computed brightness integrals. Note that only particles that contribute to the measurement can be constrained with our method. Atoms and molecules produced on the nightside must escape the shadow in order to scatter light if the excitation process is resonant-light scattering, as assumed here. The aggregate distribution of Na atoms fits a 1200 K gas, with a PSD distribution, along with a hotter component. Our models constrain the hot component, assumed to be impact vaporization, to be emitted with a 2500 K Maxwellian. Most orbits show a dawnside enhancement in the hot component broadly spread over the leading hemisphere. However, on some dates there is no dawn/dusk asymmetry. The portion of the hot/cold source appears to be highly variable.

  4. LUZ, MELATONINA E ESTRESSE OXIDATIVO NA PISCICULTURA

    Directory of Open Access Journals (Sweden)

    Claudio Alberto Gellis de Mattos Dias

    2013-12-01

    Full Text Available Em peixes, como nos mamíferos, partes do sistema nervoso estão envolvidas em mecanismos para regulação dos sistemas corporais em sintonia com o meio. O fotoperíodo é traduzido em informações fisiológicas a partir da secreção de melatonina.Parece não haver barreiras morfofisiológicas para esta indolamina, isto é, a melatonina perfunde-se rapidamente em cada célula do organismo e em alguns casos interage com receptores e membrana situados na superfície celular, e parece estar ligada à ingestão de alimentos, crescimento e atividade locomotora de peixes. São moléculas importantes metabolizando espécies reativas de oxigênio a produtos inativos e, portanto, reduzindo o dano oxidativo.Este trabalho tem por objetivo fazer um breve levantamento em artigos recentes sobre luminosidade, melatonina e o estresse oxidativo em peixes, e correlaciona-los com piscicultura. Concluímos que a luminosidade parece estar ligada a produção de melatonina, e esta molécula antioxidante, que favorece a redução do estresse oxidativo, parecem melhorar o desempenho na produção de peixes em criadouros. Palavras-chave: Melatonina, estresse oxidativo, piscicultura. DOI: http://dx.doi.org/10.18561/2179-5746/biotaamazonia.v3n3p169-176

  5. Scintillation Efficiency Measurement of Na Recoils in NaI(Tl) Below the DAMA/LIBRA Energy Threshold

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Jingke [Princeton U.; Shields, Emily [Princeton U.; Calaprice, Frank [Princeton U.; Westerdale, Shawn [Princeton U.; Froborg, Francis [Princeton U.; Suerfu, Burkhant [Princeton U.; Alexander, Thomas [Fermilab; Aprahamian, Ani [Notre Dame U.; Back, Henning O. [Princeton U.; Casarella, Clark [Notre Dame U.; Fang, Xiao [Notre Dame U.; Gupta, Yogesh K. [Notre Dame U.; Ianni, Aldo [Gran Sasso; Lamere, Edward [Notre Dame U.; Lippincott, W. Hugh [Fermilab; Liu, Qian [Notre Dame U.; Lyons, Stephanie [Notre Dame U.; Siegl, Kevin [Notre Dame U.; Smith, Mallory [Notre Dame U.; Tan, Wanpeng [Notre Dame U.; Kolk, Bryant Vande [Notre Dame U.

    2015-07-30

    The dark matter interpretation of the DAMA modulation signal depends on the NaI(Tl) scintillation efficiency of nuclear recoils. Previous measurements for Na recoils have large discrepancies, especially in the DAMA/LIBRA modulation energy region. We report a quenching effect measurement of Na recoils in NaI(Tl) from 3 to 52 keVnr, covering the whole DAMA/LIBRA energy region for dark matter-Na scattering interpretations. By using a low-energy, pulsed neutron beam, a double time-of-flight technique, and pulse-shape discrimination methods, we obtained the most accurate measurement of this kind for NaI(Tl) to date. The results differ significantly from the DAMA reported values at low energies but fall between the other previous measurements. We present the implications of the new quenching results for the dark matter interpretation of the DAMA modulation signal.

  6. Growth mechanism of NaClO3 and NaBrO3 crystals from aqueous solutions

    Indian Academy of Sciences (India)

    V Surender; N Arundhathi; K Kishan Rao

    2006-10-01

    A study of growth rates of NaClO3 and NaBrO3 has been carried out using a small growth cell by in situ observation. Normal growth rates of {100} faces of NaClO3 and {111} faces of NaBrO3 along $\\langle 110 \\rangle$ direction are measured under relatively high supersaturation ranging from 3–8%. In the initial stages of growth, {100}, {110} and {111} faces develop in NaClO3 and gradually all the faces are replaced by the {100} faces only. In the case of NaBrO3, mostly {111} faces develop with occasional occurrence of small {100} faces at the intersection of {111} faces. The growth mechanisms are investigated from growth rate vs supersaturation plots and from the observations of surface features. In the present supersaturation range, the growth mechanism appears to be due to two-dimensional growth mechanism.

  7. Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy

    Directory of Open Access Journals (Sweden)

    Cassiano Felippe Gonçalves-de-Albuquerque

    2017-04-01

    Full Text Available Lung cancer is a leading cause of global cancer deaths. Na/K-ATPase has been studied as a target for cancer treatment. Cardiotonic steroids (CS trigger intracellular signalling upon binding to Na/K-ATPase. Normal lung and tumour cells frequently express different pump isoforms. Thus, Na/K-ATPase is a powerful target for lung cancer treatment. Drugs targeting Na/K-ATPase may induce apoptosis and autophagy in transformed cells. We argue that Na/K-ATPase has a role as a potential target in chemotherapy in lung cancer treatment. We discuss the effects of Na/K-ATPase ligands and molecular pathways inducing deleterious effects on lung cancer cells, especially those leading to apoptosis and autophagy.

  8. Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy.

    Science.gov (United States)

    Felippe Gonçalves-de-Albuquerque, Cassiano; Ribeiro Silva, Adriana; Ignácio da Silva, Camila; Caire Castro-Faria-Neto, Hugo; Burth, Patrícia

    2017-04-21

    Lung cancer is a leading cause of global cancer deaths. Na/K-ATPase has been studied as a target for cancer treatment. Cardiotonic steroids (CS) trigger intracellular signalling upon binding to Na/K-ATPase. Normal lung and tumour cells frequently express different pump isoforms. Thus, Na/K-ATPase is a powerful target for lung cancer treatment. Drugs targeting Na/K-ATPase may induce apoptosis and autophagy in transformed cells. We argue that Na/K-ATPase has a role as a potential target in chemotherapy in lung cancer treatment. We discuss the effects of Na/K-ATPase ligands and molecular pathways inducing deleterious effects on lung cancer cells, especially those leading to apoptosis and autophagy.

  9. Didaktična računalniška igra na temo osnov matematične logike

    OpenAIRE

    Zupančič, Katja

    2015-01-01

    V magistrskem delu Didaktična računalniška igra na temo osnov matematične logike smo predstavili nekaj osnovnih opredelitev pojma igra ter teorijo računalniških iger in izobraževalnih računalniških iger. Pregledali smo učne načrte (splošni učni načrt za matematiko, učni načrt za izbirna predmeta logika in matematična delavnica) in učbenike za osnovno šolo, kjer se pojavljajo teme osnov matematične logike, ter glavne učne cilje tekmovanja iz logike, ki ga organizira Zveza za tehnično kulturo S...

  10. Orbital-free molecular dynamics simulations of melting in $Na_{8}$ and $Na_{20} melting in steps

    CERN Document Server

    Aguado, A; Alonso, J A; Stott, M J; Aguado, Andres; Lopez, Jose M.; Alonso, Julio A.; Stott, Malcolm J.

    1999-01-01

    The melting-like transitions of Na8 and Na20 are investigated by extensive ab initio constant energy molecular dynamics simulations, using a variant of the Car-Parrinello method which employs an explicit electronic kinetic energy functional of the density, thus avoiding the use of one-particle orbitals. Several melting indicators are evaluated in order to determine the nature of the different transitions, and comparison with other theoretical calculations is made. Both Na8 and Na20 melt over a wide range of temperature. For Na8, a first transition is observed at approx. 110 K, between a rigid phase and a phase involving isomerization between the different permutational isomers of the ground state structure. The ``liquid'' phase is completely established at approx. 220 K. For Na20, three successive transitions are observed: the first phase transition, at approx. 110 K, is associated with isomerization transitions between those permutational isomers of the ground state structure which are obtained by interchang...

  11. Decomposition reactions for NaAl H4 , Na3 Al H6 , and NaH: First-principles study

    Science.gov (United States)

    Ke, Xuezhi; Tanaka, Isao

    2005-01-01

    The electronic properties and lattice dynamics of the sodium alanate phases have been studied by the density functional calculations. The phases include NaAlH4 (space group, I41/a ), Na3AlH6 (space group, P21/n ), and NaH (space group, Fm-3m ). The electronic properties are discussed on the basis of the electronic band structures, the atomic charges, the bond overlap population analysis, and the Born effective charges. The phonon dispersion relations and phonon density of states (DOS) of the phases are calculated by a direct force-constant method. Within the quasiharmonic approximation, the calculated thermodynamic functions including the heat capacity, the vibrational enthalpy, and the vibrational entropy are in good agreement with experimental values. Three decomposition reactions are studied based on the thermodynamic functions. The reactions are (1) NaAlH4→(1)/(3)Na3AlH6+(2)/(3)Al+H2 , (2) (1)/(3)Na3AlH6→NaH+(1)/(3)Al+(1)/(2)H2 , and (3) NaH→Na+(1)/(2)H2 . The reactions (1), (2), and (3) are predicted to take place at 285, 390, and 726K , respectively, which are in good agreement with the experiment (353, 423, and 698K , respectively). The individual contributions to the reactions including the enthalpy and entropy are investigated. We found that the enthalpy for the reaction is almost constant, and the net entropy contribution ( TΔS ) to the reaction is approximately equal to the entropy contribution of the H2 gas molecule (produced in that reaction).

  12. An Inactivation Stabilizer of the Na+ Channel Acts as an Opportunistic Pore Blocker Modulated by External Na+

    OpenAIRE

    Yang, Ya-Chin; Kuo, Chung-Chin

    2005-01-01

    The Na+ channel is the primary target of anticonvulsants carbamazepine, phenytoin, and lamotrigine. These drugs modify Na+ channel gating as they have much higher binding affinity to the inactivated state than to the resting state of the channel. It has been proposed that these drugs bind to the Na+ channel pore with a common diphenyl structural motif. Diclofenac is a widely prescribed anti-inflammatory agent that has a similar diphenyl motif in its structure. In this study, we found that dic...

  13. Determinants of Substrate and Cation Transport in the Human Na+/Dicarboxylate Cotransporter NaDC3*

    OpenAIRE

    Schlessinger, A; Sun, NN; Colas, C; Pajor, AM

    2014-01-01

    Metabolic intermediates, such as succinate and citrate, regulate important processes ranging from energy metabolism to fatty acid synthesis. Cytosolic concentrations of these metabolites are controlled, in part, by members of the SLC13 gene family. The molecular mechanism underlying Na+-coupled di- and tricarboxylate transport by this family is understood poorly. The human Na+/dicarboxylate cotransporter NaDC3 (SLC13A3) is found in various tissues, including the kidney, liver, and brain. In a...

  14. Impacto da perda de peso nas adipocitocinas, na proteína C-reativa e na sensibilidade à insulina em mulheres hipertensas com obesidade central

    OpenAIRE

    2007-01-01

    OBJETIVO: Avaliar o impacto do tratamento da obesidade nas adipocitocinas, na proteína C-reativa (PCR) e na sensibilidade à insulina em pacientes hipertensas com obesidade central. MÉTODOS: O estudo foi realizado a partir do banco de dados e de amostras estocadas de soro de pacientes submetidas previamente a um estudo para tratamento de obesidade. Foram selecionadas 30 mulheres hipertensas, com idade entre 18 e 65 anos, índice de massa corpórea (IMC) > 27 kg/m², com distribuição central ...

  15. Duas fontes de proteína na dieta de cordeiros confinados

    OpenAIRE

    Gallo, Sarita Bonagurio; MERLIN,Fernanda de Almeida; MACEDO,Cássio Moreira de; Reis, Viviane Aparecida Amin

    2015-01-01

    Objetivou-se comparar dietas para cordeiros em confinamento com dois níveis de proteína e duas fontes proteicas. Foram confinados 30 cordeiros machos, não-castrados, meio sangue Dorper com Santa Inês, com idade aproximada de 2,5 meses e peso vivo inicial médio de 23kg, divididos aleatoriamente em três tratamentos: dieta controle (15% PB), dieta com alta concentração de proteína verdadeira (farelo de soja, com 19% PB) e dieta com alta concentração de nitrogênio não protéico (uréia, 19% PB). O ...

  16. Yoga como caminho de elevação na espiritualidade e na saúde

    OpenAIRE

    Lima, Vânia Cristina Lucena

    2010-01-01

    O presente estudo retrata uma pesquisa realizada em João Pessoa PB - durante o período de novembro de 2009 a outubro de 2010, sob a metodologia qualitativa da História Oral de Vida. Os objetivos foram analisar o significado do Yoga como um caminho para o desenvolvimento da espiritualidade e da saúde; delinear seu percurso histórico desde a Índia até a sua chegada na Paraíba; analisar os benefícios dessa prática na saúde física e mental das colaboradoras Ada Tavares Zenaide, Mércia Rios Ribe...

  17. Sliding wear behaviour of steel carburized using Na2CO3-NaCl

    Directory of Open Access Journals (Sweden)

    Liew Willey Y. H.

    2017-01-01

    Full Text Available Experiments have been carried out to investigate the effect of carburization process on the sliding wear resistance of mild steel. The carburization process was conducted in carbonate salts mixtures of Na2CO3-NaCl. Carburization followed by water quenching resulted in the formation of martensite with a hardness of 900 HV in the subsurface, up to the depth of 400 μm. This hardness value was substantially higher than the non-carburized steel which had a hardness of 520 HV. In the initial stage of sliding in air, abrasive wear and cluster of fine cavities due to adhesion were formed. This was followed by the formation of large-scale fracture at the cavities. The high hardness of the carburized steel reduced the severity of adhesive wear and thus the tendency of the worn surface to fracture.

  18. VPLIV SPLETNIH SOCIALNIH OMREŽIJ NA LOGISTIČNA PODJETJA

    OpenAIRE

    Zagoranski, Tamara

    2012-01-01

    Vedno več podjetij se odloča za prodajo prek spleta, saj omogoča novejši pristop do potrošnikov, kar posledično vpliva na večjo produktivnost in razpoznavnost podjetij oziroma oglaševalcev. Učinkovito orodje za znatno povečanje uspešnosti podjetij je zagotovo socialno omrežje Facebook. Uporabi portala so se pridružili tudi tržniki, saj jim tak način oglaševanja omogoča lažjo vzpostavitev novih stikov s potencialnimi partnerji, sodelovanje s potrošniki in jim zagotavlja odskočno desko v mednar...

  19. Impact of childhood stress on psychopathology Impacto de estresse na infância na psicopatologia

    Directory of Open Access Journals (Sweden)

    Elisa Brietzke

    2012-12-01

    Full Text Available OBJECTIVE: Advances in our knowledge of mental disorder (MD genetics have contributed to a better understanding of their pathophysiology. Nonetheless, several questions and doubts persist. Recent studies have focused on environmental influences in the development of MDs, and the advent of neuroscientific methodologies has provided new perspectives. Early life events, such as childhood stress, may affect neurodevelopment through mechanisms such as gene-environment interactions and epigenetic regulation, thus leading to diseases in adulthood. The aim of this paper is to review the evidence regarding the role of the environment, particularly childhood stress, in the pathophysiology of MD. METHODOLOGY: We reviewed articles that evaluated environmental influences, with a particular focus on childhood trauma, brain morphology, cognitive functions, and the development of psychopathology and MD. RESULTS AND CONCLUSION: MRI studies have shown that exposure to trauma at an early age can result in several neurostructural changes, such as the reduction of the hippocampus and corpus callosum. Cognitive performance and functioning are also altered in this population. Finally, childhood stress is related to an increased risk of developing MD such as depression, bipolar disorder, schizophrenia and substance abuse. We conclude that there is robust evidence of the role of the environment, specifically adverse childhood experiences, in various aspects of MD.OBJETIVO: Avanços no conhecimento da genética dos transtornos mentais (TM contribuíram para um melhor entendimento de suas bases fisiopatológicas. No entanto, dúvidas e questões ainda persistem. Estudos recentes têm se concentrado nas influências do ambiente no desenvolvimento de TM, e o advento de metodologias neurocientíficas oferece novas perspectivas. Eventos precoces de vida, como estresse na infância, podem ser capazes de alterar o neurodesenvolvimento através de mecanismos como intera

  20. Towards environmentally friendly Na-ion batteries: Moisture and water stability of Na2Ti3O7

    Science.gov (United States)

    Zarrabeitia, M.; Castillo-Martínez, E.; López Del Amo, J. M.; Eguía-Barrio, A.; Muñoz-Márquez, M. A.; Rojo, T.; Casas-Cabanas, M.

    2016-08-01

    We report here on the moisture and water stability of the promising Na-ion anode material Na2Ti3O7. Spontaneous Na+/H+ exchange is detected by PXRD after air exposure, forming solid solution compounds of the form Na2-xHxTi3O7 (0 techniques. Both mixed compositions crystallize in C2/m space group like H2Ti3O7, and therefore Na+/H+ exchange is found to involve a structural transition from AA stacking of [TiO6] layers to AB stacking sequence. The electrochemical behaviour of the mixed compositions vs. Na+/Na is studied as well as that of an electrode of pure Na2Ti3O7 prepared in water media. The water-processed electrode is shown to exhibit a superior cycling stability and therefore the results obtained highlight the potential of Na2Ti3O7 as a green, low cost anode material for NIBs.

  1. Microhardness studies on as-grown faces of NaClO3 and NaBrO3 crystals

    Indian Academy of Sciences (India)

    K Kishan Rao; V Surender; B Saritha Rani

    2002-12-01

    Single crystals of NaClO3 and NaBrO3 are grown from their aqueous solutions at a constant temperature of 35°C by slow evaporation by using good quality seed crystals. Systematic microhardness studies are made on as-grown faces of these crystals at various loads. Typical cracks are observed at the corners of the impressions in NaClO3 whereas in addition to the cracks at the corners microcracks also appeared in NaBrO3 crystals around the impressions. The impressions formed in NaBrO3 are not very clear as in NaClO3, a possible mechanism for it is discussed. The work hardening index number () for both these crystals is around 1.6 suggesting that these are moderately harder samples. The hardness studies point out that NaBrO3 is harder than NaClO3 ( ≈ 100 kg/mm2), this could be due to strong inter ionic forces acting between Na–Br in NaBrO3 crystals. Using Gilman’s empirical relation, hardness values are calculated from the values of elastic constants (44) and are found to be close to the experimental results.

  2. NMR and IR studies of hydroxyl groups in CaNa and MgNa forms of zeolites A

    Science.gov (United States)

    Pruski, M.; Ernst, H.; Pfeifer, H.; Staudte, B.

    1985-09-01

    By measurement of MAS proton magnetic resonance and near-infrared spectra, the existence of bridging hydroxyl groups in MgNaA and CaNaA zeolites is excluded. The MAS proton magnetic resonance lines observed at 2.5-3 ppm for CaNaA and at 3.5 ppm for MgNaA (apart from the small contributions of "terminal" OH groups) and the corresponding bands at 4576 and 4525 cm -1 in the near-infrared spectra are attributed to hydroxyl groups attached to the exchangeable cations.

  3. Central role of the Na(+)-translocating NADH:quinone oxidoreductase (Na(+)-NQR) in sodium bioenergetics of Vibrio cholerae.

    Science.gov (United States)

    Steuber, Julia; Halang, Petra; Vorburger, Thomas; Steffen, Wojtek; Vohl, Georg; Fritz, Günter

    2014-12-01

    Vibrio cholerae is a Gram-negative bacterium that lives in brackish or sea water environments. Strains of V. cholerae carrying the pathogenicity islands infect the human gut and cause the fatal disease cholera. Vibrio cholerae maintains a Na(+) gradient at its cytoplasmic membrane that drives substrate uptake, motility, and efflux of antibiotics. Here, we summarize the major Na(+)-dependent transport processes and describe the central role of the Na(+)-translocating NADH:quinone oxidoreductase (Na(+)-NQR), a primary Na(+) pump, in maintaining a Na(+)-motive force. The Na(+)-NQR is a membrane protein complex with a mass of about 220 kDa that couples the exergonic oxidation of NADH to the transport of Na(+) across the cytoplasmic membrane. We describe the molecular architecture of this respiratory complex and summarize the findings how electron transport might be coupled to Na(+)-translocation. Moreover, recent advances in the determination of the three-dimensional structure of this complex are reported.

  4. 43. Calmodulin regulating calcium sensitivity of Na channels

    Directory of Open Access Journals (Sweden)

    R. Vegiraju

    2016-07-01

    Full Text Available By extrapolating information from existing research and observing previous assumptions regarding the structure of the Na Channel, this experiment was conducted under the hypothesis that the Na Channel is in part regulated by the calmodulin protein, as a result proving calcium sensitivity of the Na Channel. Furthermore, we assume that there is a one to one stoichiometry between the Na Channel and the Calmodulin. There has been extensive research into the functionality and structure of sodium ion channels (Na channels, as several diseases are associated with the lack of regulation of sodium ions, that is caused by the disfunction of these Na channels. However, one highly controversial matter in the field is the importance of the protein calmodulin (CaM and calcium in Na channel function. Calmodulin is a protein that is well known for its role as a calcium binding messenger protein, and that association is believed to play an indirect role in regulating the Na channel through the Na channel’s supposed calcium sensitivity. While there are proponents for both sides, there has been relatively little research that provides strong evidence for either case. In this experiment, the effect of calmodulin on NaV 1.5 is tested by preparing a set of cardiac cells (of the human specie with the NaV 1.5 C-Termini and CaM protein, which were then to be placed in solutions with varying concentrations of calcium. We took special care to test multiple concentrations of calcium, as previous studies have tested very low concentrations, with Manu Ben-Johny’s team from the John Hopkins laboratory in particular testing up to a meager 50 micromolar, despite producing a well-respected paper (By comparison, the average Na channel can naturally sustain a concentration of almost 1-2 millimolar and on some occasions, reaching even higher concentrations. After using light scattering and observing the signals given off by the calcium interacting with these Nav1.5/Ca

  5. North America and South America (NA-SA) neuropathy project.

    Science.gov (United States)

    Pasnoor, Mamatha; Nascimento, Osvaldo J M; Trivedi, Jaya; Wolfe, Gil I; Nations, Sharon; Herbelin, Laura; de Freitas, M G; Quintanilha, Giseli; Khan, Saud; Dimachkie, Mazen; Barohn, Richard

    2013-08-01

    Peripheral neuropathy is a common neurological disorder. There may be important differences and similarities in the diagnosis of peripheral neuropathy between North America (NA) and South America (SA). Neuromuscular databases were searched for neuropathy diagnosis at two North American sites, University of Kansas Medical Center and University of Texas Southwestern Medical Center, and one South American site, Federal Fluminense University in Brazil. All patients were included into one of the six major categories: immune-mediated, diabetic, hereditary, infectious/inflammatory, systemic/metabolic/toxic (not diabetic) and cryptogenic. A comparison of the number of patients in each category was made between North America and South America databases. Total number of cases in North America was 1090 and in South America was 1034 [immune-mediated: NA 215 (19.7%), SA 191 (18%); diabetic: NA 148 (13.5%), SA 236 (23%); hereditary: NA 292 (26.7%), SA 103 (10%); infectious/inflammatory: NA 53 (4.8%), SA 141 (14%); systemic/metabolic/toxic: NA 71 (6.5%), SA 124 (12%); cryptogenic: NA 311 (28.5%), SA 239 (23%)]. Some specific neuropathy comparisons were hereditary neuropathies [Charcot-Marie-Tooth (CMT) cases] in NA 246/292 (84.2%) and SA 60/103 (58%); familial amyloid neuropathy in SA 31/103 (30%) and none in NA. Among infectious neuropathies, cases of human T-lymphotropic virus type 1 (HTLV-1) neuropathy in SA were 36/141(25%), Chagas disease in SA were 13/141(9%) and none for either in NA; cases of neuropathy due to leprosy in NA were 26/53 (49%) and in SA were 39/141(28%). South American tertiary care centers are more likely to see patients with infectious, diabetic and hereditary disorders such as familial amyloid neuropathies. North American tertiary centers are more likely to see patients with CMT. Immune neuropathies and cryptogenic neuropathies were seen equally in North America and South America.

  6. O Platonismo de Russell na metafísica e na matemática

    Directory of Open Access Journals (Sweden)

    Guido Imaguire

    2005-06-01

    Full Text Available Neste artigo, analiso o surgimento e a superação do Platonismo em B. Russell, tanto na sua filosofia da matemática como na sua metafísica. Começo por explicitar os argumentos que levaram Russell a aderir ao chamado "Platonismo Proposicional" - posição que será tecnicamente relevante na definição de números. Na seção seguinte, discutirei até que ponto a teoria das descrições definidas determina, necessariamente, uma adesão ao nominalismo, e as dificuldades que surgem para o logicismo conseqüentes do abandono do platonismo. Finalmente, mostrarei como a posição madura de Russell caracteriza-se mais como um reducionismo do que propriamente como um nominalismo, e como este é fundado no princípio do mínimo vocabulário.In this paper, I analyze the emergence and the overcoming of Platonism both in Russell's philosophy of mathematics and his metaphysics. I begin by examining the arguments which led Russell to endorse a position that I term "Propositional Platonism" - this position proves to be relevant for Russell's definition of numbers. In the following section, I address the question of the extent to which Russell's theory of descriptions implies the acceptance of nominalism. Moreover, I examine the difficulties which arise for logicism, if it no longer goes hand in hand with platonism. Finally, I argue argue that Russell's mature position is to be characterized as a form of reductionism rather than as a variant of nominalism

  7. Jornalismos culturais na rede: uma experiência de pesquisa compartilhada na web

    Directory of Open Access Journals (Sweden)

    Geane Alzamora

    2008-11-01

    Full Text Available O projeto Jornalismos Culturais na Rede (www.fca.pucminas.br/jnc investiga, desde 2002, paradigmas de circulação de informação cultural na rede, a partir de trabalhos acadêmicos e produtos editoriais disponí­veis na Internet. Os principais objetivos da pesquisa referem-se a: i discutir modos possí­veis de se produzir conhecimento pela Internet, tendo por fundamento a idéia de pesquisa colaborativa; ii criar categorias para referenciar informações culturais hipermidiáticas; iii identificar como se conformam os paradigmas de circulação de informação cultural na Internet: iv avaliar, junto com a comunidade virtual que delineia o projeto, as bases conceituais de um possí­vel webjornalismo cultural. Palavras-chave cultura, webjornalismo, informação, comunidade virtual Abstract Cultural Webjournalism (www.fca.pucminas.br/jnc is a project that, since 2002, has been investigating models of cultural information, by departing from academics works and editorial products available in the Internet. The main objectives in this research are: i to discuss how is it possible to produce knowledge through the Internet, founded in the idea of "research in collaboration"; ii to create categories to refer to hypermediatic cultural information; iii to identify how models of cultural information are constituted in the Internet; iv to evaluate, with the virtual community that marks this project, the conceptual bases of a possible cultural webjournalism. Key words culture, webjournalism, information, virtual community

  8. Paisagismo e modernidade na europa na década de 1920

    Directory of Open Access Journals (Sweden)

    Euler Sandeville Júnior

    2007-12-01

    Full Text Available Experiências formais realizadas a partir do final da Primeira Guerra deram novo impulso à reformulação das concepções então correntes para os jardins. Notamos algumas tendências contrastantes que coexistiam nessa época: uma, então dominante, representada por um ambiente profissional respondendo a uma demanda particular e do Estado, de caráter conservador e nacionalista, outras, de renovação, representadas por paisagistas e por arquitetos de alguma forma vinculados às vanguardas. O objetivo deste trabalho é destacar duas tendências modernizantes atuando na produção paisagística na Europa dos anos de 1920. Uma delas, desenvolvida por paisagistas e arquitetos, mostra forte influência do cubismo e do expressionismo, convergindo para o art déco, dotada de forte conotação decorativa. Gabriel Guevrekian e Robert Mallet-Stevens, são alguns dos representantes dessa tendência. Outra tendência modernizante deve-se à atuação de representantes do nascente movimento moderno em arquitetura, tanto em sua abordagem dos jardins como também nos conceitos que empregaram na criação de espaços externos. Entre a ampla gama de experiências nesse sentido, vêem-se as posturas bem diversas apresentadas por arquitetos como Le Corbusier e Erik Gunnar Asplund.

  9. Synthesis and Structure of 1D Na6 Cluster Chain with Short Na-Na Distance: Organic like Aromaticity in Inorganic Metal Cluster

    CERN Document Server

    Khatua, S; Chattaraj, P K; Roy, D R; Bhattacharjee*, Manish; Chattaraj*, Pratim K.; Khatua, Snehadrinarayan; Roy, Debesh R.

    2006-01-01

    A unique 1D chain of sodium cluster containing (Na6) rings stabilized by a molybdenum containing metalloligand has been synthesized and characterized. DFT calculations show striking resemblance in their aromatic behaviour with the corresponding hydrocarbon analogues

  10. Risbjerg: SF vandt valgkampen, NA og R tabte

    DEFF Research Database (Denmark)

    Thomsen, Søren Risbjerg

    2007-01-01

    ANALYSE: Endnu engang flyttede en valgkamp for alvor stemmer. SF gik undervejs 27 pct. frem, mens NA gik 34 pct. tilbage og R 26 pct. Udgivelsesdato: 25. november......ANALYSE: Endnu engang flyttede en valgkamp for alvor stemmer. SF gik undervejs 27 pct. frem, mens NA gik 34 pct. tilbage og R 26 pct. Udgivelsesdato: 25. november...

  11. A ideologia na obra de Antonio Carlos Pacheco e Silva

    Directory of Open Access Journals (Sweden)

    Francisco B. Assumpção Jr.

    Full Text Available O autor apresenta, através da obra de Antonio Carlos Pacheco e Silva, a questão ideológica na psiquiatria. Discute também sua importância naquele momento histórico brasileiro, bem como sua influência na psiquiatria brasileira até os dias de hoje.

  12. Infrared properties of doped and irradiated NaCl crystals

    Energy Technology Data Exchange (ETDEWEB)

    Izvekov, V.P.; Pungor, E. (Budapesti Mueszaki Egyetem (Hungary). Altalanos es Analitikai Tanszek); Gyoergyi, T.; Pungor, E. (Orszagos Frederic Joliot-Curie Sugarbiologiai es Sugaregeszseguegyi Kutato Intezet, Budapest (Hungary))

    1982-06-01

    Infrared spectra of X-ray irradiated NaCl crystals doped with Ca/sup 2 +/ and Sr/sup 2 +/ ions are presented. The localized modes of the hydrogen impurities in doped NaCl crystals and their changes induced by radiation have been studied.

  13. The early stages in the oxidation of Na

    Energy Technology Data Exchange (ETDEWEB)

    Shek, M.L. (25 Old Saddle Road, Ridge, New York 11961 (USA)); Hrbek, J. (Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973 (USA)); Sham, T.K. (Department of Chemistry, University of Western Ontario, Ontario, NA6 5B7, Canada (CA)); Xu, G. (Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973 (USA))

    1991-05-01

    We report soft x-ray photoemission results on the early stages of the oxidation of Na at {similar to}80 K. The first stage (up to {approx gt}0.5 L exposure) is characterized by a narrow O 2{ital p} level and a Na 2{ital p} surface core level shifted by {minus}0.55 eV with respect to the bulk core level. The Na 2{ital p} surface plasmon loss intensity shifts toward smaller energies, consistent with a decrease in surface conduction electron density. The second stage (starting from {similar to}1 L) is characterized by the emergence of di-oxygen'' valence levels and a Na 2{ital p} component shifted by {similar to}0.8 eV with respect to the bulk binding energy. The oxidation is strongly nonuniform, as suggested by the small oxygen doses needed for the onset of the second oxidation stage, and the continued presence of the bulk plasmon loss from metallic Na. The two new Na 2{ital p} binding energies are tentatively attributed to different final-state screening of metallic Na adjacent to dispersed oxygen atoms in the first stage, and of the Na atoms with mostly oxygen nearest neighbors in the second stage. Observations regarding large negative core level shifts upon large oxygen exposures are also summarized.

  14. Transmission channels through Na and Al atom wire

    DEFF Research Database (Denmark)

    Kobayashi, N.; Brandbyge, Mads; Tsukada, M.

    1999-01-01

    First-principles calculations of the transmission channels of single-atom-width Na and Al atom wires bridged between metallic jellium electrodes are presented. For the Na wire, a single channel contributes to the conduction with an almost full quantization value, 2e(2)/h. The conductance...

  15. Effect NaOH Concentration on Bagasse Ash Based Geopolymerization

    Directory of Open Access Journals (Sweden)

    Saloma

    2016-01-01

    Full Text Available Geopolymer is a natural adhesive material which can be developed as a substitute for cement. The natural ingredients which want to use should contain silica and alumina. This paper uses bagasse ash as a basic material of mortar geopolymer. As an adhesive, the bagasse ash should be mixed with water and another activator alkali such as sodium hydroxide (NaOH and sodium silicate (Na2SiO3. The NaOHs molarity variation are 8, 10, 12, 14 and 16 M with Na2SiO3/NaOH = 1,0 sand/bagasse ash = 2,75 and activator/bagasse ash = 0,42. This research use 50 × 50 × 50 mm cube sized specimen and conduct a compressive strength test with 3, 7, 14, 21 and 28 days. The fresh mortar test result showed that the use of NaOHs molarity variation influences the slump value and time setting. The bigger NaOH molarity variation that been used, the smaller slump value. But, the time setting is increased. While the result for density and compressive strength shown that the bigger NaOH molarity variation, the bigger density and the compressive strength. Maximum compressive strength resulted from the mixture of mortar geopolymer with 16 M concentration.

  16. Naïve Bayes classification in R

    OpenAIRE

    Zhang, Zhongheng

    2016-01-01

    Naïve Bayes classification is a kind of simple probabilistic classification methods based on Bayes’ theorem with the assumption of independence between features. The model is trained on training dataset to make predictions by predict() function. This article introduces two functions naiveBayes() and train() for the performance of Naïve Bayes classification.

  17. Opredeluvawe selen vo pomosni lekoviti sredstva so primena na AAS

    Directory of Open Access Journals (Sweden)

    Rumenka Petkovska

    2003-08-01

    Full Text Available Opredeluvanjeto selen vo pomosni lekoviti sredstva bese izvrseno so atomska apsorpciona spektrometrija so primena na grafitna pecka i hidriden sistem.Podgotovkata na primerocite bese napravena so mikrobranovo razoruvanje. Za grafitna tehnika e koristena smesa od modifikatori sto sodrzi rastvori na Pd(NO32 so masena koncentracija 1,5 g/l i Mg(NO32 so masena koncentracija 1g/l vo rastvor na HNO3 so koncentracija 2,3 mol/l. Za hidridniot sistem koristen e rastvor na NaBH4 so masen udel 1,5% vo rastvor od NaOH so masen udel 0,5%. Metodot be{e validiran preku opredeluvawe: linearnost (vo koncentraciono podracje od 15 do 75 µg/l za grafitna tehnika i 5 do 25 µg/l za hidriden sistem, tocnost, preciznost, limit na detekcija (4 µg/l za grafitna tehnika i 1 µg/l za hidriden sistem i kvantifikacija (13 µg/l za grafitna tehnika i 3 µg/l za hidriden sistem. Metodot bese primenet za opredeluvanje selen vo tri preparati vo koi selenot e vo kombinacija so: cink, bakar i vitaminite A, S i E. Dobienite rezultati pokazuvaat deka predlozenite metodi za opredeluvanje selen vo farmacevtski preparati se osetlivi, precizni, tocni i reproducibilni

  18. Experience with CsI(Na) crystals for calorimetry

    Energy Technology Data Exchange (ETDEWEB)

    Aulchenko, V.M. [Rossijskaya Akademiya Nauk, Novosibirsk (Russian Federation). Inst. Yadernoj Fiziki; Baibusinov, B.O. [Rossijskaya Akademiya Nauk, Novosibirsk (Russian Federation). Inst. Yadernoj Fiziki; Baldin, E.M. [Rossijskaya Akademiya Nauk, Novosibirsk (Russian Federation). Inst. Yadernoj Fiziki; Bondar, A.E. [Rossijskaya Akademiya Nauk, Novosibirsk (Russian Federation). Inst. Yadernoj Fiziki; Gaidarev, P.B. [Cornell Univ., Ithaca, NY (United States); Kuzmin, A.S. [Rossijskaya Akademiya Nauk, Novosibirsk (Russian Federation). Inst. Yadernoj Fiziki; Leontiev, L.A. [Rossijskaya Akademiya Nauk, Novosibirsk (Russian Federation). Inst. Yadernoj Fiziki; Oreshkin, S.B. [Rossijskaya Akademiya Nauk, Novosibirsk (Russian Federation). Inst. Yadernoj Fiziki; Ovechkin, R.P. [Rossijskaya Akademiya Nauk, Novosibirsk (Russian Federation). Inst. Yadernoj Fiziki; Shwartz, B.A. [Rossijskaya Akademiya Nauk, Novosibirsk (Russian Federation). Inst. Yadernoj Fiziki

    1996-09-21

    The performance of cesium iodide doped with sodium is studied. The design and parameters of a CsI(Na) endcap calorimeter for the KEDR detector are presented. Also reported are the results of the study of a calorimeter element consisting of a CsI(Na) crystal coupled to a vacuum phototriode. (orig.).

  19. The pea gene NA encodes ent-kaurenoic acid oxidase.

    Science.gov (United States)

    Davidson, Sandra E; Elliott, Robert C; Helliwell, Chris A; Poole, Andrew T; Reid, James B

    2003-01-01

    The gibberellin (GA)-deficient dwarf na mutant in pea (Pisum sativum) has severely reduced internode elongation, reduced root growth, and decreased leaflet size. However, the seeds develop normally. Two genes, PsKAO1 and PsKAO2, encoding cytochrome P450 monooxygenases of the subfamily CYP88A were isolated. Both PsKAO1 and PsKAO2 had ent-kaurenoic acid oxidase (KAO) activity, catalyzing the three steps of the GA biosynthetic pathway from ent-kaurenoic acid to GA(12) when expressed in yeast (Saccharomyces cerevisiae). In addition to the intermediates ent-7alpha-hydroxykaurenoic acid and GA(12)-aldehyde, some additional products of the pea KAO activity were detected, including ent-6alpha,7alpha-dihydroxykaurenoic acid and 7beta-hydroxykaurenolide. The NA gene encodes PsKAO1, because in two independent mutant alleles, na-1 and na-2, PsKAO1 had altered sequences and the five-base deletion in PsKAO1 associated with the na-1 allele cosegregated with the dwarf na phenotype. PsKAO1 was expressed in the stem, apical bud, leaf, pod, and root, organs in which GA levels have previously been shown to be reduced in na plants. PsKAO2 was expressed only in seeds and this may explain the normal seed development and normal GA biosynthesis in seeds of na plants.

  20. Cloning of neuraminidase (NA) gene and identification of its antiviral ...

    African Journals Online (AJOL)

    user

    2012-06-12

    Jun 12, 2012 ... African Journal of Biotechnology Vol. 11(47), pp. 10675-10681, 12 ... vector pGEX-NA was constructed to make NA polyclone antibody. Eukaryotic ... increasing the immune protection function (Cong and Liu,. 2008). In all, NA ...

  1. Transepithelial Na+ transport and the intracellular fluids: a computer study.

    Science.gov (United States)

    Civan, M M; Bookman, R J

    1982-01-01

    Computer simulations of tight epithelia under three experimental conditions have been carried out, using the rheogenic nonlinear model of Lew, Ferreira and Moura (Proc. Roy. Soc. London. B 206:53-83, 1979) based largely on the formulation of Koefoed-Johnsen and Ussing (Acta Physiol. Scand. 42: 298-308. 1958). First, analysis of the transition between the short-circuited and open-circuited states has indicated that (i) apical Cl- permeability is a critical parameter requiring experimental definition in order to analyze cell volume regulation, and (ii) contrary to certain experimental reports, intracellular Na+ concentration (ccNa) is expected to be a strong function of transepithelial clamping voltage. Second, analysis of the effects of lowering serosal K+ concentration (csK) indicates that the basic model cannot simulate several well-documented observations; these defects can be overcome, at least qualitatively, by modifying the model to take account of the negative feedback interaction likely to exist between the apical Na+ permeability and ccNa. Third, analysis of the strongly supports the concept that osmotically induced permeability changes in the apical intercellular junctions play a physiological role in conserving the body's stores of NaCl. The analyses also demonstrate that the importance of Na+ entry across the basolateral membrane is strongly dependent upon transepithelial potential, cmNa and csK; under certain conditions, net Na+ entry could be appreciably greater across the basolateral than across the apical membrane.

  2. Unidirectional Flux Balance of Monovalent Ions in Cells with Na/Na and Li/Na Exchange: Experimental and Computational Studies on Lymphoid U937 Cells.

    Directory of Open Access Journals (Sweden)

    Igor A Vereninov

    Full Text Available Monovalent ion traffic across the cell membrane occurs via various pathways. Evaluation of individual fluxes in whole cell is hampered by their strong interdependence. This difficulty can be overcome by computational analysis of the whole cell flux balance. However, the previous computational studies disregarded ion movement of the self-exchange type. We have taken this exchange into account. The developed software allows determination of unidirectional fluxes of all monovalent ions via the major pathways both under the balanced state and during transient processes. We show how the problem of finding the rate coefficients can be solved by measurement of monovalent ion concentrations and some of the fluxes. Interdependence of fluxes due to the mandatory conditions of electroneutrality and osmotic balance and due to specific effects can be discriminated, enabling one to identify specific changes in ion transfer machinery under varied conditions. To test the effectiveness of the developed approach we made use of the fact that Li/Na exchange is known to be an analogue of the coupled Na/Na exchange. Thus, we compared the predicted and experimental data obtained on U937 cells under varied Li+ concentrations and following inhibition of the sodium pump with ouabain. We found that the coupled Na/Na exchange in U937 cells comprises a significant portion of the entire Na+ turnover. The data showed that the loading of the sodium pump by Li/Na exchange involved in the secondary active Li+ transport at 1-10 mM external Li+ is small. This result may be extrapolated to similar Li+ and Na+ flux relationships in erythrocytes and other cells in patients treated with Li+ in therapeutic doses. The developed computational approach is applicable for studying various cells and can be useful in education for demonstrating the effects of individual transporters and channels on ion gradients, cell water content and membrane potential.

  3. Unidirectional Flux Balance of Monovalent Ions in Cells with Na/Na and Li/Na Exchange: Experimental and Computational Studies on Lymphoid U937 Cells.

    Science.gov (United States)

    Vereninov, Igor A; Yurinskaya, Valentina E; Model, Michael A; Vereninov, Alexey A

    2016-01-01

    Monovalent ion traffic across the cell membrane occurs via various pathways. Evaluation of individual fluxes in whole cell is hampered by their strong interdependence. This difficulty can be overcome by computational analysis of the whole cell flux balance. However, the previous computational studies disregarded ion movement of the self-exchange type. We have taken this exchange into account. The developed software allows determination of unidirectional fluxes of all monovalent ions via the major pathways both under the balanced state and during transient processes. We show how the problem of finding the rate coefficients can be solved by measurement of monovalent ion concentrations and some of the fluxes. Interdependence of fluxes due to the mandatory conditions of electroneutrality and osmotic balance and due to specific effects can be discriminated, enabling one to identify specific changes in ion transfer machinery under varied conditions. To test the effectiveness of the developed approach we made use of the fact that Li/Na exchange is known to be an analogue of the coupled Na/Na exchange. Thus, we compared the predicted and experimental data obtained on U937 cells under varied Li+ concentrations and following inhibition of the sodium pump with ouabain. We found that the coupled Na/Na exchange in U937 cells comprises a significant portion of the entire Na+ turnover. The data showed that the loading of the sodium pump by Li/Na exchange involved in the secondary active Li+ transport at 1-10 mM external Li+ is small. This result may be extrapolated to similar Li+ and Na+ flux relationships in erythrocytes and other cells in patients treated with Li+ in therapeutic doses. The developed computational approach is applicable for studying various cells and can be useful in education for demonstrating the effects of individual transporters and channels on ion gradients, cell water content and membrane potential.

  4. Sepsis does not alter red blood cell glucose metabolism or Na+ concentration: A 2H-, 23Na-NMR study

    Energy Technology Data Exchange (ETDEWEB)

    Hotchkiss, R.S.; Song, S.K.; Ling, C.S.; Ackerman, J.J.; Karl, I.E. (Washington Univ. School of Medicine, St. Louis (USA))

    1990-01-01

    The effects of sepsis on intracellular Na+ concentration ((Na+)i) and glucose metabolism were examined in rat red blood cells (RBCs) by using 23Na- and 2H-nuclear magnetic resonance (NMR) spectroscopy. Sepsis was induced in 15 halothane-anesthetized female Sprague-Dawley rats by using the cecal ligation and perforation technique; 14 control rats underwent cecal manipulation without ligation. The animals were fasted for 36 h, but allowed free access to water. At 36 h postsurgery, RBCs were examined by 23Na-NMR by using dysprosium tripolyphosphate as a chemical shift reagent. Human RBCs from 17 critically ill nonseptic patients and from 7 patients who were diagnosed as septic were also examined for (Na+)i. Five rat RBC specimens had (Na+)i determined by both 23Na-NMR and inductively coupled plasma-atomic emission spectroscopy (ICP-AES). For glucose metabolism studies, RBCs from septic and control rats were suspended in modified Krebs-Henseleit buffer containing (6,6-2H2)glucose and examined by 2H-NMR. No significant differences in (Na+)i or glucose utilization were found in RBCs from control or septic rats. There were no differences in (Na+)i in the two groups of patients. The (Na+)i determined by NMR spectroscopy agreed closely with measurements using ICP-AES and establish that 100% of the (Na+)i of the RBC is visible by NMR. Glucose measurements determined by 2H-NMR correlated closely (correlation coefficient = 0.93) with enzymatic analysis. These studies showed no evidence that sepsis disturbed RBC membrane function or metabolism.

  5. POGREŠKE I NESREĆE NA RADNOM MJESTU

    OpenAIRE

    Adhikari, Pralhad

    2015-01-01

    SAŽETAK: U radnom okruženju pogreške su neizbježne. Nesreće nastaju zbog ljudskih pogrešaka i grešaka u sustavu, a za posljedicu imaju neželjene štete i ozljede. Nesreće na radu uzrokuju goleme gubitke u životima i imovini. Razne teorije na različite načine objašnjavaju uzroke nesreća. Neke pripisuju nesreće ljudskim čimbenicima dok druge smatraju da se uzroci nesreća mogu naći u greškama sustava ili načinu upravljanja. Neki su ljudi skloniji pogreškama od drugih, izloženih istim čimbenicima ...

  6. The New Readout System of the NA62 LKr Calorimeter

    CERN Document Server

    Ceccucci, A; Farthouat, P; Lamanna, G; Rouet, J; Ryjov, V; Venditti, S

    2015-01-01

    The NA62 experiment [1] at CERN SPS (Super Proton Synchrotron) accelerator aims at studying Kaon decays with high precision. The high resolution Liquid Krypton (LKr) calorimeter, built for the NA48 [2] experiment, is a crucial part of the photon-veto system; to cope with the demanding NA62 re- quirements,itsback-endelectron icshadtobecompletelyrenewed. The new readout system is based on the Calorimeter REAdout Module (CREAM) [3], a 6U VME board whose design and pro- duction was sub-contracted to CAEN [4], with CERN NA62 group continuously supervising the de velopment and production phase. The first version of the board was delivered by the manufacturer in March 2013 and, as of June 2014, the full board production is ongoing. In addition to describing the CREAM board, all aspects of the new LKr readout system, including its integration within the NA62 TDAQ scheme, will be treated.

  7. Recent results from the NA62 experiment at CERN

    CERN Document Server

    Aliberti, Riccardo

    2016-01-01

    NA62 is a fixed target experiment located at the CERN SPS which aims to perform flavour physics studies in the charged kaon sector with an unprecedented precision. Due to the abundance of kaon decays with a po in the final state, NA62 is also a perfect environment to measure the neutral pion characteristics. NA62 collected a large sample of charged kaon decays with a highly efficient trigger for decays into electrons in 2007. We report about the measurement of the po electromagnetic transition form factor slope parameter in the time-like region. Between 2008 and 2014 the NA62 apparatus underwent an intense upgrade phase to improve the physics sensitivity of the experiment to precisely measure the Br (K+ !p+n ¯ n). NA62 took data in pilot runs in 2014 and 2015 reaching the final designed beam intensity. The quality of data acquired in view of the final measurement is presented.

  8. Consumo de cafeína e prematuridade

    OpenAIRE

    de Souza, Rita Adriana Gomes; Sichieri,Rosely

    2005-01-01

    A cafeína (1, 3, 7-trimetilxantina) é uma metilxantina que facilmente atravessa a barreira placentária, com quantidades substanciais passando para o líquido amniótico, sangue do cordão umbilical, plasma e urina dos neonatos. As maiores fontes de cafeína são café, chá, chocolate e refrigerantes do tipo cola. Além disso, cerca de mil drogas prescritas e 2 mil drogas não prescritas contêm cafeína, e 25 dessas drogas podem ser usadas na gravidez. Embora estudos em animais indiquem que a cafeína l...

  9. Status of the KIMS-NaI experiment

    CERN Document Server

    Kim, Kyungwon

    2015-01-01

    KIMS-NaI is a direct detection experiment searching for Weakly Interacting Massive Particles (WIMP) via their scattering off of nuclei in a NaI(Tl) crystal. The KIMS-NaI collaboration has carried out tests of six crystals in the Yangyang underground laboratory in order to develope low-background NaI(Tl) crystals. Studies of internal backgrounds crystals have been performed with the goal of reducing backgrounds levels to 1 dru at 2 keV. Pulse shape discrimination (PSD) capabilities were also investigated for distinguishing between WIMP nuclear recoil signals and electron recoil backgrounds. The PSD analysis was applied to underground data with one low background NaI(Tl) detector and the evaluation of WIMP mass limit is ongoing.

  10. Difference in Photosynthetic Response of Ryegrass Seedling to NaCI and NaHCO3 Stress%黑麦草幼苗对NaCl和NaHCO3胁迫的光合响应差异

    Institute of Scientific and Technical Information of China (English)

    刘建新; 王鑫; 贾海燕; 李东波

    2012-01-01

    为了探讨牧草光合功能对盐、碱胁迫的响应差异,采用营养液砂培方法,分别研究了不同浓度(0、50、100、150、200mmol·L^-1)NaCl和NaHCOs胁迫对黑麦草幼苗生长、叶片光合色素含量、气体交换和叶绿素荧光参数、叶绿体Hill反应活力和ATPase活性的影响。结果表明:①随着处理浓度的增加,黑麦草幼苗全株干重、叶片叶绿素和类胡萝h素含量、净光合速率(Pa)、气孔导度(Ga)和蒸腾速率(Tr)明显下降。当NaCl浓度小于100mmol·L^-1时,胞间CO2浓度(Ci)显著降低,气孔限制值(Ls)明显增加,随着NaCl浓度进一步增大,G显著增加,Ls显著减小;NaHCOs胁迫下Ci随着处理浓度增大而显著增加,Ls则显著减小。但NaHCO3胁迫下各指标下降或增加的幅度大于NaCl胁迫。②随着NaCl和NaHCOs胁迫强度的增大,黑麦草幼苗荧光参数PSII最大光化学效率(Fv/Fm)、实际光化学效率(ФPSⅡ)、光化学淬灭(qp)及叶绿体Hill反应和ATPase活性明显下降,非光化学淬灭(NPQ)显著提高,叶片吸收的光能中用于光化学反应的比例(P)显著减小,天线热耗散的比例(D)显著增大。在相同浓度下,NaHCOs胁迫的各荧光参数及Hill反应和ATPase活性的变幅大于NaCl胁迫,说明NaHCO。胁迫对幼苗的伤害程度大于NaCI胁迫。由此表明,黑麦草对碱的耐性低于盐,这可能与碱的高pH值更多引起光合色素含量下降和光合机构受到严重伤害有关。%To explore the differences of photosynthetic responses of forage to saline stress and alkaline stress, ryegrass seedlings were exposed to Hoagland's nutrient solution at five NaC1 or NaHCO3 levels (0, 50, 100, 150, 200 mmol. L^-1), and the effects of NaCl and NaHCO3 stress on plant growth, photosynthetic pigment content, gas exchange and chlorophyll fluorescence parameters, and the activities of Hill reaction and

  11. Sexualidade, Espiritualidade e Conjugalidades na Wicca Brasileira

    Directory of Open Access Journals (Sweden)

    Daniela Cordovil

    Full Text Available Resumo Este artigo propõe uma análise do papel da sexualidade nas práticas da Wicca, religião neopagã surgida na Inglaterra entre 1940 e 1950. Atualmente, a Wicca é um movimento mundial multifacetado, que segue inúmeras vertentes. Esta pesquisa investiga concepções e práticas ligadas à sexualidade presentes entre grupos que praticam a Wicca publicamente em diversas capitais do Brasil. Esses grupos estão organizados em tradições (grupos religiosos com viés iniciático que comandam associações civis com fins de resguardar direitos e promover eventos públicos para divulgação e troca de conhecimento entre praticantes da religião. Os resultados do estudo mostram que a Wicca postula uma relação intrínseca entre sexualidade, espiritualidade e liberdade, sendo suas práticas herdeiras de movimentos intelectuais diversos, como o esoterismo, a contracultura e a filosofia oriental.

  12. Absorto na ação

    Directory of Open Access Journals (Sweden)

    Michael Fried

    2010-07-01

    Full Text Available O filme Zidane, um retrato do século XXI, de Douglas Gordon e Philippe Parreno (2006 pertence à tradição de absorção que desempenhou um papel crucial na evolução da arte moderna. O autor explora a tensão entre absorção e teatralidade - central tanto para a pintura francesa do século XVIII como para a fotografia dos séculos XX e XXI - e tira conseqüências estéticas e filosóficas do filme que retrata, ao longo de todos os noventa minutos de uma partida de futebol, o meio-campista francês Zinedine Zidane.Zidane, a 21st Century Portrait, a film by Douglas Gordon and Philippe Perreno, belongs to the absorptive tradition that has played a central role in the evolution of modern art. The author explores the tension between absorption and theatricality - crucial to 18th century French art as well as to 20th and 21th century photography - and draws aesthetic and philosophical consequences of this film that depicts, throughout all the 90 minutes of a soccer match, the French midfielder Zinedine Zidane.

  13. Lugares dos mortos na cristandade ocidental

    Directory of Open Access Journals (Sweden)

    Cláudia Rodrigues

    2013-01-01

    Full Text Available Resumo. Este artigo busca refletir sobre a forte associação entre morte e cristandade no Ocidente, buscando identificar os lugares dos mortos nos diferentes sistemas de cristandade. Propõe-se aqui a viabilidade de se pensar numa certa vinculação entre determinadas atitudes e representações diante da morte e do morrer e o sistema de cristandade vigente em determinados contextos históricos, entre fins da Antiguidade tardia e o século XX, mais especificamente em países nos quais a Igreja romana exerceu hegemonia sobre a sociedade. Procura argumentar que, enquanto predominou a modalidade “constantiniana”, os mortos faziam parte do cotidiano e a morte e foram instrumentos do projeto cristianizador. Quando este modelo de Cristandade recuou, diante da emergência da chamada “Cristandade pós-constantiniana” – na qual a Igreja não mais era braço do aparelho estatal –, os mortos tinham sido afastados da cidade dos vivos e a morte, ou melhor, o medo da morte não mais representava instrumento de pressão sobre a consciência do cidadão

  14. A Avaliacäo na Narrativa

    Directory of Open Access Journals (Sweden)

    Solange de Azambuja Lira

    2008-04-01

    Full Text Available Neste trabalho pretendo analisar e discutir o papel da avaliação na narrativa de acordo com o modelo de Labov A avaliação segundo Labov e Waletzky (1967 e Labov (1972 a uma suspensão da ação básica da narrativa que tem por finalidade informar sobre a carga dramática ou o clima emocional da situação, eventos e protagonistas. E, segundo Labov, a razão de ser da narrativa, o meio que o narrador tem de indicar porque a estória e digna de ser narrada. Com a avaliação o narrador pode também enfatizar mais certos eventos do que outros e aumentar a sua influência no desenrolar dos eventos. A avaliação é um dos elementos estruturais da narrativa. Labov (1972:359-360 define a narrativa como "um metodo de recapitulação de experiências passadas Combinando uma sequência verbal de oracões a sequência de eventos que (segundo se infere ocorreram efetivamente." Os outros elementos estruturais da narrativa são: sínopse onde temos os eventos mais salientes da narrativa de uma forma resumida.

  15. Endurance testing with Li/Na electrolyte

    Energy Technology Data Exchange (ETDEWEB)

    Ong, E.T.; Remick, R.J.; Sishtla, C.I. [Institute of Gas Technology, Des Plaines, IL (United States)

    1996-12-31

    The Institute of Gas Technology (IGT), under subcontract to M-C Power Corporation under DOE funding, has been operating bench-scale fuel cells to investigate the performance and endurance issues of the Li/Na electrolyte because it offers higher ionic conductivity, higher exchange current densities, lower vapor pressures, and lower cathode dissolution rates than the Li/K electrolyte. These cells have continued to show higher performance and lower decay rates than the Li/K cells since the publication of our two previous papers in 1994. In this paper, test results of two long-term 100-cm{sup 2} bench scale cells are discussed. One cell operated continuously at 160 mA/cm{sup 2} for 17,000 hours with reference gases (60H{sub 2}/20CO{sub 2}/20H{sub 2}O fuel at 75% utilization and 30CO{sub 2}/70 air oxidant humidified at room temperature at 50% utilization). The other cell operated at 160 mA/cm{sup 2} for 6900 hours at 3 atm with system gases (64H{sub 2}/16CO{sub 2}/20H{sub 2}O at 75% utilization and an M-C Power system-defined oxidant at 40% utilization). Both cells have shown the highest performance and longest endurance among IGT cells operated to date.

  16. The NA48 LKr calorimeter readout electronics

    CERN Document Server

    Gianoli, A; Barr, C; Brodier-Yourstone, P; Buchholz, P; Ceccucci, Augusto; Cerri, C; Chlopik, A; Constantini, F; Fantechi, R; Formenti, F; Funk, W; Giudici, Sergio; Gorini, B; Guzik, J A; Hallgren, Björn I; Kozhevnikov, Yu; Iwansky, W; de La Taille, C; Lacourt, A; Laverrière, G C; Ljuslin, C; Mannelli, I; Martin-Chassard, G; Martini, M; Papi, A; Seguin-Moreau, N; Sozzi, M; Tarlé, J C; Velasco, M; Vossnack, O; Wahl, H; Ziolkowski, M

    2000-01-01

    The NA48 experiment at the CERN SPS accelerator is making a measurement of the direct CP violation parameter epsilon '/ epsilon by comparing the four rates of decay of K/sub S/ and K/sub L/ into 2 pi /sup 0/ and pi /sup +/ pi /sup -/. To reconstruct the decays into 2 pi /sup 0/ the information from the almost 13500 channels of a quasi-homogeneous liquid krypton electromagnetic calorimeter is used. The readout electronics of the calorimeter has been designed to provide a dynamic range from a few MeV to about 50 GeV energy deposition per cell, and to sustain a high rate of incident particles. The system is made by cold charge preamplifiers (working at 120 degrees K), low-noise fast shapers followed by digitizer electronics at 40 MHz sampling rate that employs a gain switching technique to expand the dynamic range, where the gain can be selected for each sample individually (i.e. every 25 ns). To reduce the amount of data collected the system contains a zero suppression circuit based on halo expansion. (12 refs)...

  17. Status for 2015, CERN NA63

    CERN Document Server

    Mikkelsen, RE; Wistisen, T

    2015-01-01

    We summarize the status for the CERN NA63 collaboration, where in 2015 we have had two runs at the CERN SPS, beamline H4: One with Ar ions at various energies around 75 GeV per nucleon, and one with electrons/positrons of 10-20 GeV. We previously refined and updated our theoretical analyses of bremsstrahlung and delta-electron emission from heavy, and medium-heavy, ultrarelativistic nuclei \\cite{Mikk15}. We thus concluded that - although not quite as interesting as for Pb projectiles - projectiles of Ar and/or Xe were suitable for the investigation, and for establishing the method to eventually measure the charge distribution of short-lived ($ct\\gtrsim3$m) fragments \\cite{Mikk14}. However, as the preliminary data analysis shows, the signal - which requires an intact projectile - is about three orders of magnitude lower than the background, stemming from photon emission (possibly originating from $\\pi^0$'s) in coincidence with projectiles that most likely are not intact after the collision. With the presently ...

  18. The NA62 GigaTracker

    CERN Document Server

    Aglieri Rinella, G; Arcidiacono, R; Biino, C; Bonacini, S; Ceccucci, A; Chiozzi, S; Cortina Gil, E; Cotta Ramusino, A; Degrange, J; Fiorini, M; Gamberini, E; Gianoli, A; Kaplon, J; Kluge, A; Mapelli, A; Marchetto, F; Minucci, E; Morel, M; Noël, J; Noy, M; Perktold, L; Perrin-Terrin, M; Petagna, P; Petrucci, F; Poltorak, K; Romagnoli, G; Ruggiero, G; Velghe, B; Wahl, H

    2016-01-01

    The GigaTracker is a hybrid silicon pixel detector built for the NA62 experiment aiming at measuring the branching fraction of the ultra-rare kaon decay K+→π+νν¯ at the CERN SPS. The detector has to track particles in a beam with a flux reaching 1.3 MHz/mm2 and provide single-hit timing with 200 ps RMS resolution for a total material budget of less than 0.5% X0 per station. The tracker comprises three 60.8 mm×27 mm stations installed in vacuum (∼10$^{−6}$mbar) and cooled with liquid C6F14 circulating through micro-channels etched inside a few hundred micron thick silicon plates. Each station is composed of a 200 μm thick silicon sensor read out by 2×5 custom 100 μm thick ASICs, called TDCPix. Each chip contains 40×45 asynchronous pixels, 300 μm×300 μm each and is instrumented with 100 ps bin time-to-digital converters. In order to cope with the high rate, the TDCPix is equipped with four 3.2 Gb/s serialisers sending out the data. We will describe the detector and the results from the 2014 an...

  19. Glutamate transporter activity promotes enhanced Na+/K+-ATPase-mediated extracellular K+ management during neuronal activity

    DEFF Research Database (Denmark)

    Larsen, Brian Roland; Holm, Rikke; Vilsen, Bente;

    2016-01-01

    , in addition, Na+/K+-ATPase-mediated K+ clearance could be governed by astrocytic [Na+]i. During most neuronal activity, glutamate is released in the synaptic cleft and is re-absorbed by astrocytic Na+-coupled glutamate transporters, thereby elevating [Na+]i. It thus remains unresolved whether the different Na...... constellations in Xenopus oocytes and determined their apparent Na+ affinity in intact oocytes and isolated membranes. The Na+/K+-ATPase was not fully saturated at basal astrocytic [Na+]i, irrespective of isoform constellation, although the β1 subunit conferred lower apparent Na+ affinity to the α1 and α2...

  20. "Penas especiais para homens especiais": as teorias biodeterministas na Criminologia Brasileira na década de 1940

    OpenAIRE

    2005-01-01

    Analisa os conceitos de periculosidade e de classificação dos criminosos na Revista de Direito Penal e Revista Brasileira de Criminologia na década de 1940. Exemplifica a continuidade, dentro do campo da Criminologia, das teorias que pregavam o determinismo biológico, no pós-guerra.