WorldWideScience

Sample records for na ehlektricheskie svojstva

  1. Utjecaj veličine čestica na svojstva tečenja granulata

    OpenAIRE

    Posavec, Jelena

    2017-01-01

    U farmaceutskoj industriji veliki udio sirovina je u obliku smjese prašaka različitih veličina i oblika te gustoće čestica. Ova svojstva prvenstveno utječu na pakiranje čestica, poroznost, homogenost, nasipnu gustoću i raslojavanje smjese prašaka te određuju reologiju praškastih smjesa. Reološka svojstva su ključna za većinu procesa u proizvodnji čvrstih ljekovitih oblika. Veličina čestica je svojstvo koje utječe na tečenje zbog pojave adhezivnosti/kohezivnosti, osim toga utječe na kemijska i...

  2. Utjecaj različitih vrsta soli na proizvodni kalo i fizikalno-kemijska svojstva Slavonske šunke

    OpenAIRE

    Kovačević, Dragan; Mastanjević, Krešimir; Kušurin, Iva

    2017-01-01

    Cilj rada je bio istražiti utjecaj različitih vrsta soli (sitne kamene i krupne morske) na proizvodni kalo i fizikalno-kemijska svojstva (masene udjele vode, masti, proteina, soli te pH vrijednost i aw) Slavonske šunke tijekom 238 dana proizvodnje. Tijekom tradicionalnog postupka proizvodnje, kontinuirano je svakih 7 dana praćen proizvodni kalo, dok su fizikalno-kemijska svojstva određena na početku proizvodnje (1. dan), na kraju procesa soljenja (28. dan) te na kraju proizvodnje (238. dan). ...

  3. Utjecaj visokog hidrostatskog tlaka, ultrazvuka i pulsirajućeg električnog polja na sastojke i svojstva mlijeka

    OpenAIRE

    Jeličić, Irena; Lisak, Katarina; Božanić, Rajka

    2012-01-01

    Visoki hidrostatski tlak, ultrazvuk i pulsirajuće električno polje pripadaju novim metodama procesiranja hrane čija primjena, najčešće u kombinaciji s toplinom ili međusobnoj kombinaciji, omogućava postizanje odgovarajuće mikrobiološke kvalitete uz minimalne gubitke prirodnih svojstava namirnica. Primjena sve tri metode je intenzivno proučavana na mlijeku kao mediju te je objavljen veliki broj radova sa obećavajućim rezultatima vezanim uz inaktivaciju mikroorganizama. Međutim, mnoštvo provede...

  4. Struktura i svojstva plazma sprej Aps - Nikal - Aluminid prevlake

    Directory of Open Access Journals (Sweden)

    Mihailo Rade Mrdak

    2013-06-01

    ženi povišenim i visokim temperaturama (Liu, White, 1985, pp.365-371, (Cahn, 1991, pp.18-25, (Chen, et al., 1993, pp.357-363, (Liu, Sikka, 1986, pp.13-16. Konkretno, ove prevlake imaju potencijalnu tražnju u avio-industriji i drugim industrijskim granama visokih performansi (Chen, et al., 1993, pp.357-363, (Liu, Sikka, 1986, pp.13-16. Ni20Al prevlaka tipično se koristi kao vezni sloj da poboljša adheziju naknadno deponovanog gornjeg sloja, kao srednji sloj za ublažavanje neusklađenosti materijala sa različitim koeficijentima termičkog širenja, kao oksidaciono otporan vezni sloj za radne temperature do 650°C, za zaštitu i revitalizaciju delova uzrokovanih habanjem, oksidacijom i vibracijama. Da bi se dobio funkcionalni sloj neophodno je pažljivo odabrati kombinaciju plazma sprej parametara. Jedan od bitnih atmosferski plazma sprej parametara je plazma sprej odstojanje koje znatno utiče na oksidaciju istopljenih čestica u toku deponovanja na podlogu i na veličinu i sadržaj pora. Prevlake deponovane sa optimalnim parametrima su guste sa metalurškom vezom na interfejsu sa osnovnim materijalom. Prah Ni20Al deponovan plazma sprej postupkom na atmosferskom pritisku proizvodi lamelarne prevlake, koje se sastoje od čvrstog rastvora  α-Ni u kojem se nalaze faze γ'-Ni3Al i u tragovima faza NiAl (Knotek, Lugscheider, 1976, pp.244-251, (Knotek, et al., 1980, pp. 282-286. Po dvojnom dijagramu Ni-Al, faza γ'-Ni3Al  se gradi sa  sadržajem aluminijuma od 12,5-14 tež.%Al, a faza NiAl sa  sadržajem aluminijuma preko 17 tež.%Al (ASM Handbook, 1992. Između lamela osnove na međugranicama se nalaze oksidi  NiO i γ -Al2O3 i pore. U ovom radu prikazani su rezultati eksperimentalnih istraživanja uticaja plazma sprej odstojanja (PS na mikrostrukturu i mehanička svojstva slojeva prevlake Ni20Al. Glavni cilj je bio da se prevlaka primeni na utvrđivaču  turbo- gasnog  motora GTD 2PV8 na radarskoj stanici. Urađene su tri grupe uzoraka sa tri različita plazma sprej

  5. Electrical properties of various aggregate states of matter / Электрические свойства разных агрегатных состояний вещества / Električna svojstva različitih agregatnih stanja materije

    Directory of Open Access Journals (Sweden)

    Leonid I. Gretchikhin

    2017-01-01

    Full Text Available Electrical properties of solids are caused by elastic polarization of clusters in case of metals while those of dielectrics result from the orientation polarization of induced and built-in electric dipoles. Orientation polarization stems from the interaction of free built-in electric dipoles with an external electric field. A physical model of the dielectric permittivity formation of metals, electrolytes, plasma, ferrites, and ferroelectrics has been developed. Theoretical calculations of the dielectric permittivity of a number of ferrites and barium titanate have been performed in particular. / Электрические свойства твердых тел обусловлены упругой поляризацией кластеров в металлах, а в диэлектриках - ориентационной поляризацией наведенных и встроенных электрических диполей. Ориентационная поляризация обусловлена взаимодействием свободных встроенных электрических диполей с внешним электрическим полем. Разработана физическая модель формирования диэлектрической проницаемости металлов, электролитов, плазмы, ферритов и сегнетоэлектриков. Конкретно выполнен теоретический расчет диэлектрической проницаемости ряда ферритов и титаната бария. / Električna svojstva čvrstih tela prouzrokovana su elastičnom polarizacijom klastera u slučaju metala, dok su dielektrična svojstva rezultat orijentacijske polarizacije indukovanih i ugrađenih električnih dipolova. Orijentacijska polarizacija proizlazi iz interakcije slobodnih ugrađenih električnih dipolova sa spolja

  6. Učinak mikrovalne dezinfekcije na polimernu bazu proteze, ljepilo i zube: osnovni pregled

    OpenAIRE

    Klironomos, Theodoros; Katsimpali, Aspasia; Polyzois, Gregory

    2015-01-01

    Svrha ovoga članka bila je sažeti trenutačno znanje o učincima mikrovalne dezinfekcije na svojstva materijala za izradu proteza. Kontrola križne infekcije u dentalnoj medicini itekako je važna u svakodnevnoj kliničkoj praksi jer su u porastu razne infektivne bolesti poput hepatitisa B i C te AIDS-a (side), a metode dezinfekcije su mnogobrojne. Najraširenija u svakodnevnoj praksi jest ona kemijska, premda istraživanja upućuju na to da se tako mijenjaju fizikalna i mehanička svojstva akrilatnih...

  7. Svojstva i struktura wolframkarbid-kobalt prevlake deponovane plazma-sprej postupkom

    Directory of Open Access Journals (Sweden)

    Mihailo Rade Mrdak

    2013-10-01

    radu predstavljeni su rezultati eksperimentalnih istraživanja uticaja protoka plazma gasa (He na mehanička svojstva i mikrostrukturu slojeva WC17Co. Glavni cilj je bio da se stara tehnologija cementacije  rukavaca vratila zameni deponovanjem WC17Co prevlake plazma-sprej tehnologijom. Analizirane su mehaničke karakteristike i mikrostrukture prevlaka da bi se odabrala prevlaka najboljih karakteristika. Prevlaka sa najboljim mehaničkim i strukturnim karakteristikama je testirana i homologovana na rukavcu vratila glavnog rotora helikoptera "gazela H42" letnim ispitivanjem u trajanju od 50 časova u VZ „Moma Stanojlović" u Batajnici. Materijali za ispitivanje i uzorci Za izradu prevlaka upotrebljen je prah firme „Sulzer Metco” sa oznakom Metco 73F-NS-1. Za izradu praha korišćena je tehnika suvo  raspršavanje/sinterovanje sa sadržajem od 83 tež.%WC i 17 tež.%Co. Prah koji se koristio u eksperimentu imao je raspon granulacije od 11 µm do 53 µm (Material Product Data Sheet, 2011. Čestice praha su porozne  i sfernog oblika. Osnove na koje su deponovane prevlake za procenu strukture i za ispitivanje mikrotvrdoće izrađene su od čelika Č.4171 (X15Cr13 EN10027 u termički neobrađenom stanju dimenzija 70x20x1,5mm . Osnove za ispitivanje čvrstoće spoja takođe su izrađene od čelika Č.4171(X15Cr13EN10027 u termički neobrađenom stanju dimenzija Ø25x50 mm (Turbojet engine-standard practices manuel TURBOMECA. Mehaničke karakterizacije prevlaka WC17Co urađene su prema standardu TURBOMECA (Turbojet engine-standard practices manuel TURBOMECA. Za merenje mikrotvrdoće i metalografska ispitivanja korišćeni su uzorci dimanzija 70 × 20 x 1,5 mm, dok su za ispitivanje zatezne čvrstoće korišćeni uzorci  Ø25 x 50 mm. Merenja mikrotvrdoća izvršena su korišćenjem Vikers dijamant piramide indenter i 300 grama opterećenje (HV0.3. Merenje je urađeno u pravcu duž lamela, u sredini i na krajevima uzorka. Na tri mesta sprovedeno je pet očitavanja, a

  8. Utjecaj infekcije virusom AEK na proizvodnju mlijeka francuske alpske koze u Hrvatskoj

    Directory of Open Access Journals (Sweden)

    Bruna Tariba

    2017-02-01

    Full Text Available Istraživan je utjecaj infekcije virusom artritis encefalitisa koza (AEK, kliničkog artritisa i subkliničkog mastitisa na trajanje laktacije, ukupno mlijeko i sastav mlijeka. Istraživanje je provedeno na uzorku od 808 koza pasmine francuska alpska koza s proizvodnih mliječnih farmi u Hrvatskoj. Uzeti su uzorci krvi za serološka testiranja i uzorci mlijeka za detekciju subkliničkog mastitisa. Prisutnost kliničkog artritisa dijagnosticirana je pregledom i palpacijom zglobova. Podaci o laktacijama i proizvodnji preuzeti su od Hrvatske poljoprivredne agencije (HPA. Zasebno su testirani utjecaji AEK infekcije i kliničkog artritisa na ukupno mlijeko, trajanje laktacije i sastav mlijeka (mast, protein, laktoza pomoću GLM procedure za modele koji su uključivali godinu mjerenja, broj laktacije i subklinički mastitis. Infekcija AEK virusom potvrđena je u 53,72 % koza od ukupnog broja koza. Od ukupnog uzorka 23,08 % inficirano je s AEK i imalo subklinički mastitis bakterijske etiologije. Nadalje 22,47 % od ukupnog broja imalo je klinički artritis. Od ukupnog broja 16,95 % bilo je AEK pozitivno i imalo klinički artritis. Utjecaj infekcije virusom AEK potvrđen je za sva analizirana svojstva u smislu smanjenja proizvodnih rezultata. Klinički artritis je pokazao značajan utjecaj na smanjenje većine proizvodnih vrijednosti osim na ukupno mlijeko, udio (% masti laktoze i ukupnu laktozu (kg. Subklinički mastitis nije značajno utjecao na trajanje laktacije, kao ni udio (% i udio masti, proteina i laktoze.

  9. Structure and properties of Ni22Cr10Al1Y coatings deposited by the vacuum plasma spray process / Структура и свойства покрытия Ni22Cr10Al1Y нанесенного методом вакуумного плазменного напыления / Struktura i svojstva prevlake Ni22Cr10Al1Y deponovane vakuum-plazma-sprej procesom

    Directory of Open Access Journals (Sweden)

    Mihailo R. Mrdak

    2017-04-01

    ценка качества покрытия. / Cilj rada jeste da se vakuum-plazma-sprej procesom deponuju slojevi prevlake Ni22Cr10Al1Y za zaštitu komponenti gasnih turbina od oksidacije i visokotemperaturne korozije. Prevlaka može znatno uticati na svojstva substrata, jer zajedno sa substratom formira kompozit. Vrsta procesa depozicije prevlake i režim termičke obrade prevlake sa substratom bitno utiču na njenu otpornost na visokotemperaturno puzanje. Deponovanje praha Ni22Cr10Al1Y urađeno je vakuum-plazma-sprej sistemom firme Plasma Technik - AG koji koristi komandni pult A-2000 i plazma pištoljem F4. Prevlaka deponovana na substratu od legure INCONEL X-750 termički je obrađena na 11000C u trajanju od 2 sata u zaštitnoj atmosferi argona. Morfologija čestica praha ispitana je metodom skening elektronske mikroskopije. Ispitivanja mikrotvrdoće slojeva rađena su metodom HV0.3 i čvrstoće spoja metodom ispitivanja na zatezanje, koja su bila u skladu sa standardom Pratt & Whitney. Mikrostruktura slojeva prevlake u deponovanom stanju ispitana je na svetlosnom mikroskopu. Nagrizanje prevlake rađeno je mešanjem azotne kiseline 2,5 ml HNO3 sa 7,5 ml fluorovodonične kiseline HF. Analiza mikrostrukture nagrizene prevlake pre i posle termičke obrade, kao i debljina difuzione zone, izvedena je na svetlosnom mikroskopu, na osnovu čega je ocenjen kvalitet prevlake.

  10. Ispitivanje mehanizma nukleofilnih supstitucionih reakcija kompleksa zlata(III)

    OpenAIRE

    Đeković, Ana

    2013-01-01

    Lekovi na bazi platine imaju važnu ulogu u lečenju tumora. Klinički uspeh platinskih jedinjenja izazvao je veliko interesovanje za ispitivanje drugih platinskih i neplatinskih lekova koji bi ispoljavali bolja citotoksična svojstva, dobre antitumorske karakteristike i povoljniji farmakološki profil. Različita jedinjenja jona metala (npr. rutenijuma, kalaja, paladijuma, titana, zlata, bakra) su intenzivno ispitivana tokom poslednje tri decenije kao potencijalni medikamenti u borbi protiv tum...

  11. A serendipidade na medicina e na anestesiologia

    OpenAIRE

    Vale, Nilton Bezerra do; Delfino, José; Vale, Lúcio Flávio Bezerra do

    2005-01-01

    JUSTIFICATIVA E OBJETIVOS: Neste trabalho foram examinados mais de uma centena dos mais felizes acoplamentos de uma mente brilhante com a sorte benfazeja (serendipidade), através da releitura das mais relevantes histórias sobre invenções e descobertas relacionadas à ciência (n = 46), à Medicina (n = 46) e à Anestesiologia (n = 16). CONTEÚDO: Conceito de serendipidade; exemplos célebres de serendipidade em Ciência e Tecnologia; serendipidade na pesquisa e prática médicas; serendipidade na Anes...

  12. NA60 Status Report

    CERN Document Server

    Usai, G

    2010-01-01

    This report shortly summarizes the main results obtained from the analysis of the NA60 data during 2010, perspectives for the analysis activity during 2011 and the requests to CERN following from them. In addition, renewed interest is expressed for a possible continuation of NA60, including future running at lower SPS energies.

  13. At NA2

    CERN Multimedia

    1977-01-01

    One of the NA2 calorimeter sections is moved in. The NA2 calorimeter was divided in two halves, to the left and the right of the beam, each half consisting of sheets of passive high Z material interleaved with blades of plastic scintillators. The photo shows on the right, the upstream 'electron' module with eleven lead plates for a total radiation length of 20.

  14. Polarization dependence of Na* + Na* associative ionization revisited

    NARCIS (Netherlands)

    Meijer, H.A.J.; Meulen, H.P. v.d.; Morgenstern, R.; Hertel, I.V.; Meyer, E.; Witte, R.

    1986-01-01

    The dependence of the associative ionization process Na 3 2P3/2 + Na 3 2P3/2 → Na2+ + e- on the polarization of the laser light used for Na excitation was independently investigated in Utrecht and Berlin. The purpose of this paper is to clarify discrepancies between two other earlier experimental

  15. Letramento na contemporaneidade

    OpenAIRE

    Kleiman, Angela B.

    2014-01-01

    Neste trabalho examino a relação entre letramento e contemporaneidade, tomando como base para a discussão o letramento no mundo escolar e sua relação com os letramentos de outras instituições do mundo contemporâneo, a fim de determinar as relações entre as finalidades contemporâneas da leitura e da escrita (em outras palavras, o que significa ser letrado na contemporaneidade) e as práticas mobilizadas e as atividades realizadas na escola para atingir essas finalidades. Através de diversos exe...

  16. Nietzsche na moda

    OpenAIRE

    José,João

    2016-01-01

    Resumo Ao resgatar o filósofo alemão do esquecimento, Stefan Zweig seria o principal responsável pela atual "voga Nietzsche". A edição brasileira de seu livro em 1931 e o artigo "L'actualité de Nietzsche", publicado anonimamente na França em 1933, atestariam o crescente interesse pelo autor de Zaratustra . A presença de Nietzsche na cena contemporânea, todavia, dever-se-ia não somente aos ensaios de outros estudiosos como Salomé (1893), Bertram (1918), Andler (1920) e Walz (1932), mas a um fe...

  17. Senzorska procjena svježeg mesa pakiranog u modificiranoj atmosferi

    OpenAIRE

    Pintarić, Toni

    2016-01-01

    Cilj ovog rada bio je odrediti na koji način se mijenjaju senzorska svojstva svježeg mesa pakiranog u modificiranoj atmosferi u kojoj je sastav plinova bio 70% O2 i 30% CO2, skladištenog kroz 8 dana. Uspoređivali su se uzorci pakirani u modificiranoj atmosferi sa onima pakiranima u atmosferi zraka, na način da se provela deskriptivna senzorska procjena na hedonističkoj skali od 0 do 9. Iz dobivenih rezultata može se zaključiti da su uzorci pakirani u modificiranoj atmosferi imali bolju sočn...

  18. Riso na epilepsia

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    Edymar Jardim

    1967-06-01

    Full Text Available São estudados três casos de síndrome convulsiva temporal, com manifestações concomitantes de riso na sua fase inicial. As características principais foram a imotivação e á incoercibilidade do riso. Esses sintomas desapareceram com o uso de anticonvulsivantes.

  19. Biotecnologia na agricultura

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    Helaine Carrer

    2010-01-01

    Full Text Available A expectativa de o crescimento populacional atingir 9 bilhões de habitantes em 2050 em adição às questões da sustentabilidade e do aquecimento global nos desafiam a aumentar a oferta de alimentos. Uma metodologia alternativa que contribua para a redução do impacto desse cenário envolve a biotecnologia, que, nas últimas décadas, trouxe marcantes oportunidades tecnológicas na agricultura, resultando em relevante desenvolvimento na obtenção de novas variedades de plantas, na melhoria da qualidade de diversos alimentos e atualmente também na bioenergia. As técnicas biotecnológicas envolvendo os marcadores moleculares, a genômica e a transformação genética estão transformando a agricultura e são discutidas neste artigo.The expected population growth to reach 9 billion by 2050 in addition to issues of sustainability and global warming challenges us to increase the supply of food. An alternative approach to help reducing the impact of this scenario involves biotechnology which in recent decades has brought remarkable technological opportunities in the agriculture that resulted in relevant development in obtaining new plant varieties, improved quality of different foods, and now also in bioenergy. The biotechnology techniques involving molecular markers, genomics and genetic transformation are transforming agriculture and will be discussed in this article.

  20. Hidroma subdural na fossa posterior

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    José Carlos Vasques

    1970-03-01

    Full Text Available Os autores relatam um caso de hidroma subdural na fossa craniana posterior conseqüente a traumatismo na região occipital. O paciente foi operado com pleno sucesso. A raridade da localização de hidroma na fossa posterior é salientada, sendo discutidos os possíveis mecanismos etio-patogênicos.

  1. A epilepsia na neurocisticercose

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    Luís Marques-Assis

    1972-12-01

    Full Text Available Foram estudados 131 casos de epilepsia com etiologia cisticercótica comprovada. A idade variou de 2 a 68 anos; 75 pacientes eram de sexo masculino e 56 de sexo feminino; 117 eram brancos, 10 pardos, três pretos e um amarelo. A idade de início da doença predominou na primeira década. O estudo foi feito em relação ao tipo de epilepsia, ao tempo decorrido após a primeira crise, à freqüência das crises e ao eletrencefalograma relativamente às epilepsias em geral. Investigação foi feita também em relação à cefaléia, aos achados neurológicos, liquóricos, radiológicos simples e contrastados e anátomo-patológicos. A análise dos resultados permitiu aos autores as seguintes conclusões: 1 No grupo de neurocisticercose o início da doença predominou na primeira e a partir da quarta década em relação às epilepsias em geral. 2 Dentre as manifestações clínicas predominaram as formas convulsivas da doença (61%, sendo as crises bravas-jacksonianas as menos freqüentes (4%; quando comparadas com as epilepsias em geral, verifica-se incidência menor das convulsões generalizadas na neurocisticercose. 3 Quanto ao tempo de doença, verifica-se predomínio das formas de duração mais curta (um ano ou menos na neurocisticercose. 4 A severidade da epilepsia, traduzida pela freqüência das crises, foi menor no grupo com neurocisticercose. 5 Excluídos os casos com anormalidades eletrencefalográficas contínuas, foram encontrados maiores índices percentuais de EEG normal na neurocisticercose que nas epilepsias em geral. 6 A cefaléia estava presente em 68% dos casos, assumindo caráter paroxístico na maior parte (78%; em 67% dos casos com cefaléia paroxística não havia concomitantemente sinais de hipertensão intracraniana; nos casos com cefaléia contínua, em apenas dois (13% esses sinais não estavam presentes. 7 Na maior parte dos casos (62% as manifestações epilépticas se apresentaram isoladamente, sem sinais neurol

  2. The CERES / NA45 experiment

    CERN Multimedia

    Laurent Guiraud

    2000-01-01

    Ceres is one of the second generation heavy ion experiments at CERN's SPS. It is dedicated to the study of electron-positron pairs in relativistic nuclear collisions. NA45 is one of the seven experiments (NA44, NA45, NA49, NA50, NA52, WA97/NA57 and WA98) involved in CERN's Heavy Ion programme which provided evidence for the existence of a new state of matter, the quark-gluon plasma. In this state, quarks, instead of being bound up into more complex particles such as protons and neutrons, are liberated and roam freely. Theory predicts that this state must have existed at about 10 microseconds after the Big Bang, before the formation of matter as we know it today.

  3. na Perua

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    Jorge Carvalho

    1989-01-01

    Full Text Available Antes de se caracterizar como tentativa de ensaio ou de análise a qualquer coisa, o presente artigo tem, antes de mais nada, a pretensão de se constituir uma provocação ao debate acerca da questão do esporte na escola. A provocação parte basicamente do relato da minha experiência pessoal como Secretário da Educação do Município de Aracaju, cargo que exerci no período de 1º de janeiro de 1986 a 27 de janeiro de 1987.

  4. Envolvimento pulmonar na polimiosite

    Directory of Open Access Journals (Sweden)

    Direndra Hasmucrai

    2010-07-01

    Full Text Available Resumo: Introdução: A polimiosite (PM e a dermatomiosite são classificadas como miopatias inflamatórias idiopáticas. O envolvimento pulmonar por PM é pouco frequente, estando descrito na literatura em cerca de 10% de casos.Os autores apresentam um caso de uma mulher de 75 anos, com queixas de febre, perda ponderal, artralgias, mialgias e diminuição simétrica e proximal da força muscular com impotência funcional dos membros superiores e inferiores, com início um mês antes do internamento. Apresentava infiltrados pulmonares na telerradiografia de tórax. Após estudo exaustivo estabeleceu-se o diagnóstico de envolvimento pulmonar na forma de pneumonia organizativa por PM. Efectuou-se corticoterapia e terapêutica com micofenolato com melhoria clínica, analítica e radiológica.Conclusão: Neste caso, foi a alteração na telerradiografia de tórax numa doente sem sintomatologia respiratória que levou ao estudo exaustivo até ao diagnóstico de PM, realçando mais uma vez a importância da telerradiografia no rastreio de patologias de outros foros.Rev Port Pneumol 2010; XVI (4: 671-677 Abstract: Introduction: Polymyositis and dermatomyositis are classified as idiopathic inflammatory myopathies. Interstitial lung disease is rare and is described in the literature in about 10% of cases.The authors describes a case of 75 year old woman presenting with one month evolution of fever, weight loss, arthralgia, myalgia and symmetric and proximal muscle weakness of upper and lower limbs. Nonspecific interstitial changes was found in chest X-ray. After exhaustive study, the diagnosis of pulmonary envolvement in the form of organizing pneumonia by polymyositis, was established. Glucocorticoids and mycophenolate were prescribed with good clinical, analytical and radiological outcome.Conclusion: In this case, it was the changes in the chest X-ray in a patient without respiratory sym ptomatology, that conducted to exhaustive study to polymyositis

  5. Envolvimento pulmonar na polimiosite

    Directory of Open Access Journals (Sweden)

    Direndra Hasmucrai

    2010-07-01

    Full Text Available Resumo: Introdução: A polimiosite (PM e a dermatomiosite são classificadas como miopatias inflamatórias idiopáticas. O envolvimento pulmonar por PM é pouco frequente, estando descrito na literatura em cerca de 10% de casos.Os autores apresentam um caso de uma mulher de 75 anos, com queixas de febre, perda ponderal, artralgias, mialgias e diminuição simétrica e proximal da força muscular com impotência funcional dos membros superiores e inferiores, com início um mês antes do internamento. Apresentava infiltrados pulmonares na telerradiografia de tórax. Após estudo exaustivo estabeleceu-se o diagnóstico de envolvimento pulmonar na forma de pneumonia organizativa por PM. Efectuou-se corticoterapia e terapêutica com micofenolato com melhoria clínica, analítica e radiológica. Conclusão: Neste caso, foi a alteração na telerradiografia de tórax numa doente sem sintomatologia respiratória que levou ao estudo exaustivo até ao diagnóstico de PM, realçando mais uma vez a importância da telerradiografia no rastreio de patologias de outros foros. Abstract: Introduction: Polymyositis and dermatomyositis are classified as idiopathic inflammatory myopathies. Interstitial lung disease is rare and is described in the literature in about 10% of cases.The authors describes a case of 75 year old woman presenting with one month evolution of fever, weight loss, arthralgia, myalgia and symmetric and proximal muscle weakness of upper and lower limbs. Nonspecific interstitial changes was found in chest X-ray. After exhaustive study, the diagnosis of pulmonary envolvement in the form of organizing pneumonia by polymyositis, was established. Glucocorticoids and mycophenolate were prescribed with good clinical, analytical and radiological outcome. Conclusion: In this case, it was the changes in the chest X-ray in a patient without respiratory symptomatology, that conducted to exhaustive study to polymyositis diagnosis, enhancing once again the

  6. Comprometimento pulmonar na leptospirose

    Directory of Open Access Journals (Sweden)

    Jorge Eduardo Manhães de Carvalho

    1992-03-01

    Full Text Available Em 23 pacientes com leptospirose apresentando comprometimento pulmonar, internados no Hospital Universitário Antônio Pedro da XJFF, Niterói, hemoptise e hemoptóicos foram observados em 21,7% e 30,4%, respectivajnente. Gasometria arterial revelou hipoxemia e hipocapnia na maioria dos casos. Radiografia de tórax em 15 pacientes mostrou comprometimento alveolar em 60%, comprometimento intersticial-reticular em 6%, padrão misto (alveolar e intersticial em20%e ausência de alterações radiológicas em 14%. A necrópsiade 13 pacientes mostrou edema, congestão e hemorragia nos pulmões em 100% dos casos. A hemorragia foi focal em 46% e difusa em 54% dos casos. Houve formação de membrana hialina em 30% e trombos de fibrina em 46% dos pulmões estudados, o que estabelece o diagnóstico da coagulação intravascular disseminada e a ocorrência da síndrome de angústia respiratória na leptospirose.

  7. ANALIZA POSLOVNE KULTURE NA JAPONSKEM

    OpenAIRE

    Ocvirk, Katja

    2012-01-01

    Poslovanje na mednarodnih trgih se z globalizacijo vedno bolj spreminja. V delu diplomskega seminarja sem opredelila kulturo in opisala njene pomembne sestavine ter značilnosti. Spoznala sem, da mora biti poslovnež, ki deluje na mednarodnem trgu, zelo dobro pripravljen in seznanjen s kulturnimi razlikami, da se izogne nepotrebnim napakam in spodrsljajem. Menim, da moramo pri poslovanju s poslovnimi partnerji, ki prihajajo iz drugih kultur, vedeti, kako deluje njihovo poslovno okolje. Na ...

  8. Dentalni amalgam

    OpenAIRE

    Galić, Nada; Šutalo, Jozo; Prpić-Mehičić, Goranka; Anić, Ivica

    1994-01-01

    Dentalni amalgam je bio materijal izbora za ispune na stražnjim zubima tijekom proteklih 150 godina. U radu je prikazan p o vijesni razvoj amalgama, njegov obvezni sastav, te podjela dentalnih amalgama prema količinskom udjelu bakra i prema obliku čestica. Navedena su svojstva amalgama s posebnim osvrtom na njegovu toksičnost. Poznato je da se posljednjih godina pojačao napad na amalgam i u znanstvenoj i u popularnoj literaturi, a u svezi s njegovim navodnim patološkim djelovanjem ...

  9. NA48 prototype calorimeter

    CERN Multimedia

    1990-01-01

    This is a calorimeter, a detector which measures the energy of particles. When in use, it is filled with liquid krypton at -152°C. Electrons and photons passing through interact with the krypton, creating a shower of charged particles which are collected on the copper ribbons. The ribbons are aligned to an accuracy of a tenth of a millimetre. The folding at each end allows them to be kept absolutely flat. Each shower of particles also creates a signal in scintillating material embedded in the support disks. These flashes of light are transmitted to electronics by the optical fibres along the side of the detector. They give the time at which the interaction occurred. The photo shows the calorimeter at NA48, a CERN experiment which is trying to understand the lack of anti-matter in the Universe today.

  10. Na Cauda do Cometa

    Science.gov (United States)

    Voelzke, M. R.

    2009-01-01

    Quando viam um cometa, os antigos gregos imaginavam uma estrela com uma vasta cabeleira. Não à toa, a palavra deriva do termo koma, que significa cabelo. Constituídos por fragmentos de gelo e gases, os cometas possuem um núcleo sólido, que pode ter vários quilômetros de diâmetro, e uma cauda que sempre aponta na direção contrária ao Sol, devido aos ventos solares. Graças à aparência de pontos luminosos em movimento (ao contrário de outros astros, que parecem estáticos), esses corpos celestes foram interpretados por diferentes povos com muito misticismo, inspirando mitos tanto de boas-novas como de maus presságios. Conheça algumas dessas histórias:

  11. A ENGENHARIA NA ESCOLA

    Directory of Open Access Journals (Sweden)

    Valéria Pelizzer Casara

    2015-04-01

    Full Text Available Este projeto teve por objetivo principal mostrar às jovens do ensino médio, como as áreas de exatas e de engenharia podem estar inseridas em situações rotineiras por elas vivenciadas e incentivá-las para ingressarem nessas áreas. O projeto foi executado na escola de ensino Médio Nelson Horostecki na cidade de Chapecó, Santa Catarina. Mostrou-se de forma simples que as áreas de exatas e de engenharia têm aplicações práticas nas nossas vidas. No desenvolvimento do projeto, realizaram-se oficinas na escola cujo tema principal abordado foi o processo de fabricação do chocolate, visto que o mesmo é um produto muito apreciado pelas adolescentes. Dentro dessa temática, foram trabalhadas as questões que envolvem conhecimentos das áreas de exatas e de engenharia, mais especificamente a Engenharia Ambiental. O projeto auxiliou na formação cidadã e também na escolha profissional das meninas. Muitas das alunas participantes nunca haviam tido contato direto com alunos graduandos de cursos na área das exatas. Mais ainda, este projeto oportunizou a aproximação da universidade com a comunidade externa. Palavras-chave: Extensão Universitária, Ciências Exatas e Engenharia, Chocolate, Oficinas.   Engineering in the school Abstract: The main objective of this project was to show high school female students how the exact sciences and engineering can be included in their routine situations encouraging them to entering in these areas. The project was carried out at the Nelson Horostecki High School in Chapecó, Santa Catarina State, Brazil. It was showed in a simple manner how exact sciences and engineering have practical applications in our lives. Workshops were conducted in the school during the execution of the project in which the main subject was the chocolate manufacturing process, since chocolate is a product greatly appreciated by the young female people. Within this matter, the activities were performed using the knowledge of

  12. Hodler à Iéna

    OpenAIRE

    2017-01-01

    A la mort de Hodler, on demanda que les planches qui recouvrait la fresque de Iéna, depuis la protestation contre le bombardement de Reims, soit enlevées. Les autorités de Iéna ont refusé énergiquement.

  13. Valores na escola

    Directory of Open Access Journals (Sweden)

    Menin Maria Suzana De Stefano

    2002-01-01

    Full Text Available Neste texto pretende-se discorrer sobre valores morais na escola e suas implicações para a formação de professores. Para tanto discutir-se-á, em primeiro lugar, e brevemente, o que são valores morais, ou éticos, e como a escola pode situar-se em relação a eles. Em seguida, serão relatadas algumas observações a respeito de valores de professores e práticas daí decorrentes. São comentados resultados de pesquisa que ilustram a transmissão de valores de forma doutrinal e a educação moral e cívica tal como realizada na ditadura militar, e, por outro lado, a posição relativista e/ou de laissez-faire que certas escolas podem adotar, metodologicamente, sobre a educação em valores. Finalmente, defender-se-á a idéia de que é necessária uma discussão sobre valores pelos diversos membros da escola e uma opção por uma metodologia para ensiná-los, seja os professores, em sua formação inicial e continuada, seja os alunos. A teoria de desenvolvimento moral de Jean Piaget será apresentada como uma referência possível para a educação em valores. Exemplos de situações escolares de conflito de valores entre direção, pais e alunos são discutidas para ilustrar como uma escola pode adotar um procedimento democrático de educação em valores, que se apresenta como um terceiro caminho possível de educação moral nas escolas, além das posições doutrinárias ou relativistas.

  14. A aposta na filosofia

    Directory of Open Access Journals (Sweden)

    Márcio Suzuki

    2011-12-01

    Full Text Available Para Hume, filosofar é uma atividade semelhante às demais ocupações humanas. A decisão que leva à atividade filosófica é menos resultado de uma argumentação teórica do que fruto de um cálculo prático, que é entendido como uma caça ou um jogo. O objetivo deste trabalho será o de mostrar que no jogo filosófico perde quem joga sério demais. A aposta na filosofia tem que passar pelo bom humor e pela diversão: uma resposta a Pascal?For Hume, philosophy is in itself neither more nor less important than other human activities. On the contrary, it can be explained from its resemblance with game and hunting. If one chooses to dedicate himself to philosophy, his decision is not the consequence of logical reasoning, but depends on practical evaluation, which has something to do with gambling. The following text tries to show that in philosophy, like in other games, the loser will be the one who plays too earnestly. The philosophical game requires good humour and some relaxation: Is this a good answer to Pascal's pari?

  15. A Arquitetura na Cidade

    Directory of Open Access Journals (Sweden)

    Euler Sandeville Junior

    2013-07-01

    Full Text Available Este artigo é uma reflexão sobre três casos em que a arquitetura define a configuração do espaço público, investigando seus significados e pressupostos. São levantadas questões que não comportam respostas definitivas, mas que induzem a alguns parâmetros para discutir a atuação do arquiteto no espaço público, nas áreas centrais de nossas cidades. Nosso título é, sem dúvida, devedor do célebre trabalho de Aldo Rossi, a Arquitetura da cidade (1966. Porém, nos ocupamos apenas da inserção da arquitetura na cidade e numa perspectiva teórica muito distinta, reconhecendo para o projeto do objeto arquitetônico uma dependência do espaço e do tempo e das relações sociais que assim se estabelecem. São analisados o Memorial da América Latina, a estação Barra Funda do Metrô e a Praça da Sé. São aqui entendidos como campos de projeto da paisagem e, como tal, problematizados.

  16. O SUBLIME NA MODERNIDADE

    Directory of Open Access Journals (Sweden)

    Martha de Almeida

    2009-03-01

    Full Text Available A obra Uma investigação filosófica sobre a origem de nossas idéias do sublime e dobelo, do sensualista inglês Edmund Burke (1757, data as origens do sublime na Modernidade. Nosublime ocorre é um prazer ligado à dor, um "horror delicioso" que sentimos quando acreditamosque estamos em perigo sem que isso esteja ocorrendo realmente. Em O mundo como Vontade erepresentação Schopenhauer assume as influências que sofreu de Kant no que diz respeito à suainterpretação sobre o belo e o sublime, porém difere dele quanto à natureza dessa impressão. ParaSchopenhauer a experiência estética pressupõe a dissolução da subjetividade num movimento decontemplação das idéias livre do querer imposto pela vontade individual. As idéias deSchopenhauer influenciaram a estética do Nietzsche de O nascimento da tragédia.

  17. SPOLNO NADLEGOVANJE NA DELOVNEM MESTU

    OpenAIRE

    Rubič, Gašper

    2016-01-01

    V diplomskem delu smo v uvodu predstavili problem spolnega nadlegovanja na delovnem mestu in predstavili podjetje TEKSTIL d.d. V nadaljevanju smo z anketo raziskali, ali problem spolnega nadlegovanja na delovnem mestu v obravnavanem podjetju obstaja in če, kako se nanj odziva okolje. V teoretičnem delu smo nadaljevali in predstavili definicijo spolnega nadlegovanja, ki je kakršna koli oblika nezaželenega verbalnega in neverbalnega ali fizičnega ravnanja spolne narave z učinkom ali nameno...

  18. Hemisferectomia na hemiplegia infantil

    Directory of Open Access Journals (Sweden)

    Rolando A. Tenuto

    1956-03-01

    Full Text Available Os autores relatam o caso de um paciente com 18 anos de idade, portador de paralisia cerebral instalada aos 4 anos de idade após moléstia febril prolongada (hemiplegia esquerda, crises convulsivas generalizadas, freqüentes e rebeldes à medicação, deficiência mental e alterações de conduta. O eletrencefalograma e o pneumencefalograma revelaram alterações graves do hemisfério direito; tendo o primeiro destes exames demonstrado a existência de perturbações propagadas ao outro hemisfério. Foi praticada a hemisferectomia direita. Durante o ato cirúrgico, por exigência técnica foram extirpados, além do hemisfério cerebral, os dois terços rostrais do núcleo caudado e o núcleo amigdalóide. No pós-operatório foi intercorrência de osteomielite e meningite, medicadas com antibióticos e seqüestrectomia. Apesar da complicação pós-operatória, instalou-se progressiva melhora em relação à conduta social; diminuiu também a espasticidade no membro inferior esquerdo e não mais se repetiram as crises convulsivas. Não foram observadas modificações quanto ao rendimento intelectual e quanto aos distúrbios sensitivos que existiam antes da intervenção cirúrgica. O exame neurocular mostrou hemianopsia homônima esquerda. Êstes resultados são concordantes com os assinalados na literatura sobre o assunto.

  19. Active transport of Na+ by reconstituted Na,K-ATPase

    International Nuclear Information System (INIS)

    Boldyrev, A.A.; Svinukhova, I.A.

    1987-01-01

    The ability of ATP, CTP, ITP, GTP, and UTP to support ouabain-sensitive accumulation of Na + by proteoliposomes with a reconstituted Na/K-pump was investigated. At a low [Na + ]/[K + ] ratio in the medium (20 mM/50 mM), a correlation is observed between the proton-accepting capacity of the nucleotide and its effectiveness as a substrate of active transport. To test the hypothesis of the importance of the presence of a negative charge in the 1-position of the purine (3-pyrimidine) base of the nucleotide for mutual transitions between the Na- and K-conformations of Na,K-ATPase they used two analogs of ATP: N 1 -hydroxy-ATP, possessing proton acceptor capacity, and N 1 -methoxy-ATP, in the molecule of which the negative charge is quenched by a methyl group. The first substrate supports active accumulation of Na + in proteoliposomes at the same rate as ATP, whereas the second substrate is relatively ineffective

  20. Risbjerg: Historisk stemmeskred med NA

    DEFF Research Database (Denmark)

    Thomsen, Søren Risbjerg

    2007-01-01

    ANALYSE: NA flytter 12,3 pct. af stemmerne i majs meningsmålinger - historisk mange vælgere på en måned, skriver professor Risbjerg. Udgivelsesdato: 3. juni 2007......ANALYSE: NA flytter 12,3 pct. af stemmerne i majs meningsmålinger - historisk mange vælgere på en måned, skriver professor Risbjerg. Udgivelsesdato: 3. juni 2007...

  1. Na via do Behemoth

    Directory of Open Access Journals (Sweden)

    Gérard Rabinovitch

    2008-06-01

    Full Text Available O momento nazista permanece um enigma impensado de que a cultura contemporânea continua cativa. O autor levanta a hipótese de que a persistência desse enigma e seus estragos duráveis se devem à insistência dos pensamentos político, sociológico e filosófico em construírem o nazismo à luz da metáfora hobbesiana do Leviatã. Propõe retomar a questão do nazismo sob a perspectiva do Behemoth, antônimo do Leviatã. Para tanto, sugere a necessidade de retornar a Freud e à psicanálise, balizas de um possível novo pensamento do político que escrutine a destrutividade nazista. Propõe ainda sondar as homologias entre nazismo, corjas e máfias, com base na figura da " heroicização da violência" que lhes seria comum. E avança um modelo " econômico" : a quimera, suscetível de capturar o caráter heterotópico e heterocrônico de sua construção criminosa.The paths of Behemoth. The Nazi moment remains as the thoughtless enigma of which contemporary culture is still captive. The author raises the hypothesis where the persistency of this enigma and its durable damages are due to the insistence of the political, social and philosophical thoughts in building the Nazism at the view of the Hobbesian metaphor of Leviathan. It is here proposed to resume the Nazism matter under Behemoth's perspective, antonym to Leviathan. For such, it is suggested a necessity to look back at Freud and the psychoanalysis, structured by a possible new political thought which scrutinizes the destructivity of the Nazism. It is also here proposed to gaze at the homologies between Nazism, mafias and gangs, with a base in the figure of " violence as a heroically act" that are their common ground. The author also advances an economical model: the chimera susceptible to capture the heterotopic and heterochronic character of its criminal construction.

  2. Estresse ocupacional na enfermagem atuante na unidade de terapia intensiva

    OpenAIRE

    Borges Teixeira, Larissa; Portela Veloso, Lorena Uchôa; Universidade Estadual do Piauí; Pereira Ribeiro, Ítalo Arão; Universidade Estadual do Piauí; Nunes de Oliveira, Tauane; Instituto de Ensino Superior Franciscano; Leal Cortez, Antônio Carlos; Universidade Estadual do Piauí

    2017-01-01

    Introdução: O estresse tem sido um dos problemas que mais tem acometido a equipe de enfermagem dentro da unidade de terapia intensiva (UTI), causando prejuízo funcional, bem como instabilidade na saúde desses profissionais. Objetivo: Descrever, através da revisão integrativa, o estresse no trabalho da enfermagem na UTI, bem como identificar fatores, sinais e sintomas associados ao estresse ocupacional. Método: Trata-se de uma pesquisa integrativa, utilizando como banco de dados a Biblioteca V...

  3. Corpo e sexualidade na gravidez

    Directory of Open Access Journals (Sweden)

    Natalúcia Matos Araújo

    2012-06-01

    Full Text Available Estudo etnográfico que teve como objetivo compreender como as gestantes vivenciam os processos fisiológicos do seu corpo durante a gestação e a sua repercussão na sexualidade. A pesquisa envolveu sete mulheres residentes em bairro popular de São Paulo. Na coleta de dados, utilizou-se observação participante e entrevista com questões norteadoras. Os dados foram apresentados na forma de narrativa e posteriormente organizados nas categorias: Percebendo as transformações corporais; Convivendo com as mudanças no corpo; Sentimentos e sensações na vida sexual durante a gestação e imaginando o corpo e a sexualidade após a gestação. As mulheres referiram-se às transformações do corpo como desconfortos e expressaram a preocupação de que fossem definitivas. Expressaram o desejo de que, após o parto, o corpo volte a ser como era e que volte a sentir desejo sexual. O reconhecimento destes fatos constitui-se numa ferramenta primordial na adequação das práticas profissionais.

  4. All new for NA62

    CERN Multimedia

    Antonella Del Rosso

    2012-01-01

    This week sees the start of the first run of the new NA62 experiment. This will be a unique opportunity for the collaboration to test its new beam, new detectors and new data acquisition system before the physics run in 2014. Speaking to the Bulletin, the NA62 technical coordinator Ferdinand Hahn shares the many challenges that the various teams faced to be on time for beam. Ready, steady, start!   A Large Angle Veto detector (white) in place in the NA62 decay volume (blue). With components from almost all the detectors in place downstream of the decay point of the mother particles – the kaons – and of the KTAG detector that tags the kaons before they decay, NA62 is ready for its first technical run. This unique run will test all the equipment as well as the trigger and the data acquisition systems. “This year, we will have about five weeks of beam from the SPS before the long shutdown of all the CERN machines,” says Ferdinand Hahn, NA62 Technical Co-...

  5. Kostel na Lesné

    OpenAIRE

    Pospíšil, Vojtěch

    2017-01-01

    Tato teoretická diplomová práce se zabývá prostorovou akustikou a s tím úzce spojenou problematikou doby dozvuku. Součástí práce je zpracování návrhu akustických úprav kostela na základě ručního výpočtu, který byl dále upravován ve specializovaném softwaru Odeon Room Acoustics Program. Pro okolní zástavbu kostela byla vytvořena hluková studie v programu Hluk+, aby bylo posouzeno, jaký bude mít tato novostavba hlukový dopad z kostelních zvonů dopad na své okolí. Na základě specializace, bylo v...

  6. gigapanorama of NA 62 cavern

    CERN Multimedia

    Brice, Maximilien

    2015-01-01

    The image shows the new rare Kaon decay experiment at CERN, called NA62. The NA62 experiment is 270 metres long and includes a 120-metre-long vacuum tank, shown here, housing several of the particle detectors. (Note: the experiment axis is a straight line, the curving of the tank is an optical effect of the photo.) Kaons are particles that decay into lighter elementary particles. The kaon decay processes are mostly well known, except for some very rare decay modes. For example, NA62 is investigating a rare decay predicted by the Standard Model in which a kaon decays into one pion and two neutrinos. This process occurs only once every 10 billion decays. The understanding of such ultra-rare decays are of great importance because they test the Standard Model in energy ranges not accessible by direct measurements. They are therefore complementary to the measurements at the LHC. ultra high definition on demand (photolab@cern.ch).

  7. OGLAŠEVANJE NA FACEBOOKU

    OpenAIRE

    Renko, Katica

    2013-01-01

    V magistrskem delu smo se seznanili z oglaševanjem na Facebooku. S pregledom gradiva, ki nam je ponujeno, smo preverili pogoje, načine, oblike … oglaševanja, ki pa smo jih s pregledom situacije v praksi preverili in dopolnili. Ob zaključku dela lahko rečemo, da je oglaševanje preko FB enostavnejše, cenejše, dostopnejše, omogoča nam ažurnost in samo komunikacijo z naslovniki, ki so potencialni kupci naših ponudb. Množični mediji nam omogočajo mnogotero obliko oglaševanja. Izbrana oblika ponuja...

  8. Properties of the coating deposited with the diffusion of Mo&O2 oxidized powder using the APS process / Свойства покрытия, нанесенного диффузионнымоксиднымпорошком Mo&O2методом APS / Svojstva prevlake deponovane difuziono oksidiranim prahom Mo&O2 primenom APS procesa

    Directory of Open Access Journals (Sweden)

    Mihailo R. Mrdak

    2017-07-01

    етодом световой микроскопии. Микроструктура покрытия состоит из ламелей Мо и тонких оксидных прослоек MoO2 и MoO3 вокруг ламелей Мо. Анализ полученных результатов доказал, что слои покрытия Mo&O2 с диффузионными оксидными частицами Мо обладают структурой и механическими характеристиками, позволяющими нанесение данного покрытия на поверхности рабочих участков в условиях износа и скольжения при бессмазочном трении. / Prah Mo&O2 ima značajnu ulogu u proizvodnji prevlaka sa povišenom otpornošću na klizanje u uslovima bez primene maziva. Prevlake Mo&O2 imaju mali koeficijent frikcije i dobre karakteristike na habanje pri mehaničkim naprezanjima. Radi proizvodnje prevlaka visoke tvrdoće, prah Mo&O2 je deponovan plazmom sa optimalnim parametrima. Karakterizacija oblika površine čestica oksidnog praha i površine preloma prevlake izvedena je metodom SEM, a mikrostruktura slojeva primenom svetlosne mikroskopije. Mikrostruktura prevlake sastoji se od lamela Mo i tankih filmova primarnih oksida MoO2 i MoO3 koje okružuju lamele Mo. Analiza dobijenih rezultata pokazala je da slojevi prevlake Mo&O2 sa difuziono oksidiranim česticama Mo imaju strukturu i mehaničke karakteristike koje omogućuju njenu primenu na površinama radnih delova u uslovima habanja i klizanja trenjem bez maziva.

  9. NA60 frees the quarks

    CERN Multimedia

    2003-01-01

    Fitted with new state-of-the-art silicon detectors, NA60 is prepared to study the phase transition from confined hadronic matter to a deconfined (free) quark-gluon plasma, a state of matter which probably existed an instant after the Big Bang.

  10. Hodler et Iéna

    OpenAIRE

    2017-01-01

    Suites de la protestation contre le bombardement de la cathédrale de Reims. Le recteur de l'Université de Jena propose d'enlever le tableau monumental de Hodler "Départ des étudiants d'Iéna pour la guerre de libération contre Napoléon en 1813".

  11. NA62: Hidden Sector Physics

    CERN Document Server

    Cesarotti, Carissa Joyce

    2016-01-01

    Modern experimental physics is often probing for new physics by either finding deviations from predictions on extremely precise measurements, or by looking for a new signal that cannot be explained with existing models. The NA62 experiment at CERN does the former by measuring the ultra-rare decay $K^+ \\rightarrow \\pi^+ \

  12. The system NaVO3-Na2WO4-Na2W2O7

    International Nuclear Information System (INIS)

    Kazanbekov, V.R.; Gasanaliev, A.M.; Kazanbekov, R.G.

    1994-01-01

    Phase diagrams of sodium metavanadate-sodium ditungstate, sodium metavanadate-sodium tungstate systems and surface of primary crystallization of sodium metavabadate-sodium tungstate-sodium ditungstate system were studied. The system sodium metavanadate-sodium ditungstate is eutectic one. Compound NaVO 3 x2Na 2 WO 4 is formed in solid state in sodium metavanadate-sodium tungstate system. Liquidus surface of sodium metavanadate-sodium tungstate-sodium ditungstate is presented by three crystallization fields of initial components. Composition and melting point of ternary eutectics are determined

  13. Europlanet NA2 Science Networking

    Science.gov (United States)

    Harri, Ari-Matti; Szego, Karoly; Genzer, Maria; Schmidt, Walter; Krupp, Norbert; Lammer, Helmut; Kallio, Esa; Haukka, Harri

    2013-04-01

    Europlanet RI / NA2 Science Networking [1] focused on determining the major goals of current and future European planetary science, relating them to the Research Infrastructure that the Europlanet RI project [2] developed, and placing them in a more global context. NA2 also enhanced the ability of European planetary scientists to participate on the global scene with their own agenda-setting projects and ideas. The Networking Activity NA2 included five working groups, aimed at identifying key science issues and producing reference books on major science themes that will bridge the gap between the results of present and past missions and the scientific preparation of the future ones. Within the Europlanet RI project (2009-2012) the NA2 and NA2-WGs organized thematic workshops, an expert exchange program and training groups to improve the scientific impact of this Infrastructure. The principal tasks addressed by NA2 were: • Science activities in support to the optimal use of data from past and present space missions, involving the broad planetary science community beyond the "space club" • Science activities in support to the preparation of future planetary missions: Earth-based preparatory observations, laboratory studies, R&D on advanced instrumentation and exploration technologies for the future, theory and modeling etc. • Develop scientific activities, joint publications, dedicated meetings, tools and services, education activities, engaging the public and industries • Update science themes and addressing the two main scientific objectives • Prepare and support workshops of the International Space Science Institute (ISSI) in Bern and • Support Trans National Activities (TNAs), Joined Research Activities (JRAs) and the Integrated and Distributed Information Service (IDIS) of the Europlanet project These tasks were achieved by WG workshops organized by the NA2 working groups, by ISSI workshops and by an Expert Exchange Program. There were 17 official WG

  14. UDIO POLICIKLIČKIH AROMATSKIH UGLJIKOVODIKA U UZORCIMA DIZELSKOG GORIVA HPLC METODOM

    OpenAIRE

    Tomić, Tatjana; Šegudović, Nikola

    2003-01-01

    Sažetak Primjenska svojstva dizelskog goriva ovise o odnosu sastava zasićenih i aromatskih ugljikovodika. Zakonska regulativa diktira da se smanjuje udio aromatskih, a posebno policikličkih ugljikovodika. Određivanje pojedinih komponenti iz grupe aromata je složen zadatak pa se analize svode na određivanje grupnog sastava aromata. Pod grupnim sastavom se podrazumijeva udio mono aromata, di aromata te tri i više aromata s tim da se zbroj di aromata i tri i više aromata naziva policiklički a...

  15. Na+-stimulated ATPase of alkaliphilic halotolerant cyanobacterium Aphanothece halophytica translocates Na+ into proteoliposomes via Na+ uniport mechanism

    Directory of Open Access Journals (Sweden)

    Soontharapirakkul Kanteera

    2010-08-01

    Full Text Available Abstract Background When cells are exposed to high salinity conditions, they develop a mechanism to extrude excess Na+ from cells to maintain the cytoplasmic Na+ concentration. Until now, the ATPase involved in Na+ transport in cyanobacteria has not been characterized. Here, the characterization of ATPase and its role in Na+ transport of alkaliphilic halotolerant Aphanothece halophytica were investigated to understand the survival mechanism of A. halophytica under high salinity conditions. Results The purified enzyme catalyzed the hydrolysis of ATP in the presence of Na+ but not K+, Li+ and Ca2+. The apparent Km values for Na+ and ATP were 2.0 and 1.2 mM, respectively. The enzyme is likely the F1F0-ATPase based on the usual subunit pattern and the protection against N,N'-dicyclohexylcarbodiimide inhibition of ATPase activity by Na+ in a pH-dependent manner. Proteoliposomes reconstituted with the purified enzyme could take up Na+ upon the addition of ATP. The apparent Km values for this uptake were 3.3 and 0.5 mM for Na+ and ATP, respectively. The mechanism of Na+ transport mediated by Na+-stimulated ATPase in A. halophytica was revealed. Using acridine orange as a probe, alkalization of the lumen of proteoliposomes reconstituted with Na+-stimulated ATPase was observed upon the addition of ATP with Na+ but not with K+, Li+ and Ca2+. The Na+- and ATP-dependent alkalization of the proteoliposome lumen was stimulated by carbonyl cyanide m - chlorophenylhydrazone (CCCP but was inhibited by a permeant anion nitrate. The proteoliposomes showed both ATPase activity and ATP-dependent Na+ uptake activity. The uptake of Na+ was enhanced by CCCP and nitrate. On the other hand, both CCCP and nitrate were shown to dissipate the preformed electric potential generated by Na+-stimulated ATPase of the proteoliposomes. Conclusion The data demonstrate that Na+-stimulated ATPase from A. halophytica, a likely member of F-type ATPase, functions as an electrogenic Na

  16. Photodesorption of Na atoms from rough Na surfaces

    DEFF Research Database (Denmark)

    Balzer, Frank; Gerlach, R.; Manson, J.R.

    1997-01-01

    We investigate the desorption of Na atoms from large Na clusters deposited on dielectric surfaces. High-resolution translational energy distributions of the desorbing atoms are determined by three independent methods, two-photon laser-induced fluorescence, as well as single-photon and resonance......-enhanced two-photon ionization techniques. Upon variation of surface temperature and for different substrates (mica vs lithium fluoride) clear non-Maxwellian time-of-flight distributions are observed with a cos θ angular dependence and most probable kinetic energies below that expected of atoms desorbing from...... atoms are scattered by surface vibrations. Recent experiments providing time constants for the decay of the optical excitations in the clusters support this model. The excellent agreement between experiment and theory indicates the importance of both absorption of the laser photons via direct excitation...

  17. Photodesorption of Na atoms from rough Na surfaces

    DEFF Research Database (Denmark)

    Balzer, Frank; Gerlach, R.; Manson, J.R.

    1997-01-01

    atoms are scattered by surface vibrations. Recent experiments providing time constants for the decay of the optical excitations in the clusters support this model. The excellent agreement between experiment and theory indicates the importance of both absorption of the laser photons via direct excitation......We investigate the desorption of Na atoms from large Na clusters deposited on dielectric surfaces. High-resolution translational energy distributions of the desorbing atoms are determined by three independent methods, two-photon laser-induced fluorescence, as well as single-photon and resonance......-enhanced two-photon ionization techniques. Upon variation of surface temperature and for different substrates (mica vs lithium fluoride) clear non-Maxwellian time-of-flight distributions are observed with a cos θ angular dependence and most probable kinetic energies below that expected of atoms desorbing from...

  18. Obiteljska i bračna psihoterapija

    OpenAIRE

    Štalekar, Vlasta

    2010-01-01

    U radu je ukratko prikazana povijest obiteljske terapije na temelju koje se prati razvoj novih koncepata i terapijskih modela. Prikazana je podjela obiteljskih i bračnih terapija na brojne pravce, a navedene u ovom radu su sistemska, dinamska, strukturalna, strateška, transgeneracijska, iskustvena (prvenstveno je didaktičkog karaktera jer se u praksi ovi modeli uvelike preklapaju i nadopunjuju). Svaki terapijski model na jedinstven način tumači disfunkcije obiteljskog sustava t...

  19. Novel aspects of Na+,K+-ATPase

    OpenAIRE

    Aizman, Oleg

    2002-01-01

    Na,K-ATPase, an integral membrane protein expressed in each eukaryotic cell, serves as the major determinant of intracellular ion composition. In the current study we investigated novel aspects of Na,K-ATPase function and regulation. It is well established that Na,K-ATPase activity is regulated by reversible phosphorylation. New findings in this study are: 1) the level of intracellular Ca 2. concentration determines the functional effects of PKA and PKC-mediated Na,K-ATP...

  20. Carne suína

    OpenAIRE

    Ortigara, Claudino

    2000-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. A carne suína é a fonte de proteína animal mais consumida no mundo. No entanto, em muitos países e em especial no Brasil o consumo per capita é muito baixo. Como conseqüência disso, limita-se o crescimento do segmento produtivo e uma série de benefícios socioeconômicos que são gerados pela atividade suinocultura.Com esse trabalho, buscamos uma explicação para entender a resistência da população ao consum...

  1. Economia na consulta de Endodontia

    OpenAIRE

    Pinto, Diogo Filipe Cardoso

    2016-01-01

    Introdução: Em Portugal a realidade actual, clínica e financeira do exercício da Medicina Dentária é bem distinta da do final do séc. XX devido à pletora de Médicos Dentistas e à baixa de honorários por acto Médico registada nos últimos anos. Objectivos: Este trabalho teve como objectivo perceber um pouco sobre os detalhes a ter em consideração aquando da abertura de uma clínica centrada na realização de tratamentos na área da Endodontia, e como publicitá-la de forma legal e apelativa. Pre...

  2. A Umbanda Portuguesa na Internet

    Directory of Open Access Journals (Sweden)

    Ismael Pordeus Júnior

    2004-01-01

    Full Text Available A partir de considerações sobre o processo de transculturação da Umbanda de Omolocô vou a propósito do grupo religioso do Terreiro de Umbanda Ogum Megê em Lisboa - Portugal discutir a textualização da memória. Como outras religiões que visam hoje o universal a Umbanda utiliza novas tecnologias disponíveis na Internet. Esse novo meio de comunicação favorece o processo de transculturação religiosa. Utilizando uma abordagem antropológica procuro realizar um estudo dos sites da Umbanda portuguesa na Internet, propondo uma visão ampla da utilização de novas tecnologias utilizadas para difusão da religião. Opto pelo estudo de caso, pois penso que permite uma melhor abordagem desse campo tecnológico.

  3. Otto Richard Gottlieb na UFRRJ

    OpenAIRE

    Raimundo Braz Filho; Universidade Estadual do Norte Fluminense Darcy Ribeiro; Mário Geraldo de Carvalho; Universidade Federal Rural do Rio de Janeiro

    2011-01-01

    Informações importantes da trajetória científica e produtiva do Prof. Otto Richard Gottlieb e sobre seu legado são revelados por dois de seus ex-alunos. Revelam sua perseverança na criação de grupos comprometidos com pesquisas em produtos naturais no Brasil. Inicialmente na Universidade de Brasília (UnB) e, em consequência de pressões políticas da década de sessenta, seu grupo deslocou-se para outras instituições recebendo apoio da Universidade Federal de Minas Gerais (UFMG), do Centro de Pes...

  4. Makosa Yanayofanywa na Wanafunzi Wanaojifunza Kiswahili kama ...

    African Journals Online (AJOL)

    Makala haya, yanashughulika na makosa ambayo hufanywa na wanafunzi wanaojifunza Kiswahili kama lugha ya pili katika shule za sekondari nchini Uganda. Mtafiti ameyaainisha makosa mbalimbali na kuyaeleza kiusahihi. Makala yanaeleza namna ambavyo makosa hayo hutokea. Yaani, kama ni makosa ...

  5. NA50 quark-gluon plasma experiment

    CERN Multimedia

    1997-01-01

    View of the NA50 detector, which studies quark-gluon plasma. The picture shows one of the six hodoscopes, made of 48 scintillator counters, used in the muon trigger of the NA50 spectrometer. The picture shows one of the six hodoscopes, made of 48 scintillator counters, used in the muon trigger of the NA50 spectrometer

  6. Pseudo-ternary phase diagram in the Na2O-Na2O2-NaOH system

    International Nuclear Information System (INIS)

    Saito, Jun-ichi; Tendo, Masayuki; Aoto, Kazumi

    1997-10-01

    Generally, the phase diagrams are always used to understand the present state of compounds at certain temperature. In order to understand the corrosion behavior of structural material for FBR by main sodium compounds (Na 2 O, Na 2 O 2 and NaOH), it is very important to comprehend the phase diagrams of their compounds. However, only Na 2 O-NaOH pseudo-binary phase diagram had been investigated previously in this system. There is no study of other pseudo-binary or ternary phase diagrams in the Na 2 O-Na 2 O 2 -NaOH system. In this study, in order to clarify the present states of their compounds at certain temperatures, the pseudo-binary and ternary phase diagrams in the Na 2 O-Na 2 O 2 -NaOH system were prepared. A series of thermal analyses with binary and ternary component system has been carried out using the differential scanning calorimetry (DSC). The liquidus temperature and ternary eutectic temperatures were confirmed by these measurements. The beneficial indications for constructing phase diagrams were obtained from these experiments. On the basis of these results, the interaction parameters between compounds which were utilized for the Thermo-Calc calculation were optimized. Thermo-Calc is one of thermodynamic calculation software. Consequently the accurate pseudo-binary and ternary phase diagrams were indicated using the optimized parameters. (author)

  7. Homocisteína Homocysteine

    Directory of Open Access Journals (Sweden)

    Lindalva Batista Neves

    2004-10-01

    Full Text Available A homocisteína, formada a partir da metionina hepática, é metabolizada nas vias de desmetilação e de transulfuração, sendo que seus valores plasmáticos e urinários refletem a síntese celular. Sua determinação, realizada em jejum e após sobrecarga de metionina, caracteriza as diferenças dessas vias metabólicas, principalmente quando de natureza genética. A hiper-homocisteinemia tem sido associada a maior risco de eventos aterotrombóticos, e a literatura sugere associação causal, independente de outros fatores de risco para doença arterial. Diminuição da homocisteína plasmática para valores normais é seguida de redução significante na incidência de doença aterotrombótica. A relação entre homocisteína e o fígado vem adquirindo importância nos dias atuais, uma vez que alterações das lipoproteínas e da depuração de metionina são comuns em pacientes com doença hepática crônica (hepatocelular e canalicular. O tratamento da hiper-homocisteinemia fundamenta-se na suplementação alimentar e medicamentosa de ácido fólico e vitaminas B6 e B12.Homocysteine, formed from hepatic methionine, is metabolized through the pathways of demethylation and transsulfuration. Its plasmatic and urinary values reflect the cell synthesis. Its determination after fasting and increased infusion of methionine shows the differences of these two metabolic pathways, mainly when it is related to genetic diseases. Hyperhomocysteinemia has been associated with a higher risk of vascular thrombotic events. Several authors suggest a causal relationship between these events independently of other risk factors for vascular diseases. Decrease in plasmatic homocysteine to normal levels is followed by a significant reduction on the incidence of vascular thrombotic events. The correlation between the liver and homocysteine is becoming more important because of the recent findings that alterations of lipoproteins and methionine clearance are

  8. Myocardial Na,K-ATPase: Clinical aspects

    OpenAIRE

    Kjeldsen, Keld

    2003-01-01

    The specific binding of digitalis glycosides to Na,K-ATPase is used as a tool for Na,K-ATPase quantification with high accuracy and precision. In myocardial biopsies from patients with heart failure, total Na,K-ATPase concentration is decreased by around 40%; a correlation exists between a decrease in heart function and a decrease in Na,K-ATPase concentration. During digitalization, around 30% of remaining pumps are occupied by digoxin. Myocardial Na,K-ATPase is also influenced by other drugs...

  9. Istraživanje uticaja nekih parametara na osetljivost eksplozivnih materija na toplotni impuls

    OpenAIRE

    Jeremić Radun

    2002-01-01

    Ispitivana je osetljivost nekoliko vrsta eksplozivnih materija na toplotni impuls merenjem vremena zadrške u zavisnosti od temperature. Na osnovu eksperimentalnih rezultata određene su vrednosti energije aktivacije i predeksponencijalni faktori u jednačini Semjonova. Istraživan je i uticaj mase ispitivanog uzorka, granulacije i veličine kristala eksploziva na osetljivost na toplotni impuls. Pokazano je da ovi parametri imaju značajan uticaj na osetljivost eksplozivnih materija, pa je neophodn...

  10. Silicene for Na-ion battery applications

    KAUST Repository

    Zhu, Jiajie

    2016-08-19

    Na-ion batteries are promising candidates to replace Li-ion batteries in large scale applications because of the advantages in natural abundance and cost of Na. Silicene has potential as the anode in Li-ion batteries but so far has not received attention with respect to Na-ion batteries. In this context, freestanding silicene, a graphene-silicene-graphene heterostructure, and a graphene-silicene superlattice are investigated for possible application in Na-ion batteries, using first-principles calculations. The calculated Na capacities of 954mAh/g for freestanding silicene and 730mAh/g for the graphenesilicene superlattice (10% biaxial tensile strain) are highly competitive and potentials of >0.3 V against the Na/Na potential exceed the corresponding value of graphite. In addition, the diffusion barriers are predicted to be <0.3 eV.

  11. Hali ya taaluma ya ukalimani Tanzania: jana, leo na kesho ...

    African Journals Online (AJOL)

    Umuhimu wa ukalimani katika mawasiliano umeongezeka kutokana na utandawazi. Utandawazi umerahisisha kukutanika na kuwasiliana kwa watu wazungumzao lugha tofauti kupitia wakalimani. Kutokana na ongezeko hilo la umuhimu wa ukalimani, kumekuwa na jitihada mbalimbali katika nchi mbalimbali kuhakikisha ...

  12. Docência na universidade: professores inovadores na USP

    Directory of Open Access Journals (Sweden)

    Chamlian Helena Coharik

    2003-01-01

    Full Text Available O artigo trata de pesquisa realizada com um grupo de professores inovadores da Universidade de São Paulo tendo como objetivo procurar subsídios para a formação do professor universitário. Esses docentes foram entrevistados, solicitando que detalhassem melhor suas experiências inovadoras; explicassem as razões pelas quais haviam introduzido modificações em sua forma de trabalho; explicitassem as relações entre sua atividade de docência e de pesquisa, expressassem o papel que atribuíam ao ensino na universidade, bem como a forma pela qual sua trajetória acadêmica havia se cumprido até então. A diversidade de experiências relatadas e, ao mesmo tempo, a convergência de visões a respeito de suas funções de ensino e de pesquisa na universidade permitem-nos afirmar que, mais do que uma formação pedagógica específica, a sensibilização para as dificuldades do ensino e a valorização institucional dessa atividade consistiriam em grande avanço para a formação do professor.

  13. Na alvorada de um sport

    OpenAIRE

    Sartori, Carina

    2013-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas, Programa de Pós-graduação em História, Florianópolis, 2013 Em Florianópolis, a primeira Sociedade de Regatas organizada, meados do século XIX, contaria com a participação dos Coronéis da Marinha e da Escola de Menores e Marinheiros da Canhoneira. Na virada do século, a fundação do Clube 29 de Abril permitiria que as atividades relacionadas ao Remo fossem oferecidas a todos que se associ...

  14. A Umbanda Portuguesa na Internet

    OpenAIRE

    Ismael Pordeus Júnior

    2004-01-01

    A partir de considerações sobre o processo de transculturação da Umbanda de Omolocô vou a propósito do grupo religioso do Terreiro de Umbanda Ogum Megê em Lisboa - Portugal discutir a textualização da memória. Como outras religiões que visam hoje o universal a Umbanda utiliza novas tecnologias disponíveis na Internet. Esse novo meio de comunicação favorece o processo de transculturação religiosa. Utilizando uma abordagem antropológica procuro realizar um estudo dos sites da Umbanda portuguesa...

  15. Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease

    DEFF Research Database (Denmark)

    Toustrup-Jensen, Mads Schak; Einholm, Anja P.; Schack, Vivien

    2014-01-01

    The neurological disorders familial hemiplegic migraine type 2 (FHM2), alternating hemiplegia of childhood (AHC), and rapid-onset dystonia parkinsonism (RDP) are caused by mutations of Na+,K+-ATPase α2- and α3-isoforms, expressed in glial and neuronal cells, respectively. Although these disorders......, addressing the question to what extent they cause a change of the intracellular Na+ and K+ concentrations ([Na+]i and [K+]i) in COS cells. C-terminal extension mutants generally showed dramatically reduced Na+ affinity without disturbance of K+ binding, as did other RDP mutants. No phosphorylation from ATP...... was observed for the +28 mutation of α2, despite a high expression level. A significant rise of [Na+]i and reduction of [K+]i was detected in cells expressing mutants with reduced Na+ affinity, and did not require a concomitant reduction of the maximal catalytic turnover rate or expression level. Moreover, two...

  16. O ATLETISMO NA PERSPECTIVA EDUCACIONAL

    Directory of Open Access Journals (Sweden)

    Leandro Araujo de Sousa

    2017-06-01

    Full Text Available A educação física escolar deve proporcionar experiências aos alunos para o seu desenvolvimento integral. As aulas muitas vezes são reduzidas ao ensino de esportes tradicionais, o que limita o repertório de movimentos dos alunos. Dessa forma o presente estudo de revisão objetiva problematizar o atletismo no ambiente escolar e propor possibilidades pedagógicas para seu ensino. Nesta pesquisa propomos tratar o ensino do atletismo na escola, caracterizando-o pelo seu repertório de movimentos que são naturais ao ser humano, como correr, saltar e lançar, o que possibilita maior praticidade em sua aplicação pedagógica, porém essas possibilidades não são consideradas no ambiente educacional. Diante dos dados encontrados, sugerimos que esse esporte seja abordado de forma multidimensional no ambiente escolar contextualizando-o à visão de algumas correntes teóricas. Nessa perspectiva do esporte educacional, o atletismo pode, assim como deve ser trabalhado nas aulas de educação física como instrumento pedagógico de ensino e auxiliar na formação do aluno de forma global.

  17. Identidades Homossexuais na Territorialidade Tradicionalista

    Directory of Open Access Journals (Sweden)

    Edipo Djavan dos Reis Göergen

    2015-12-01

    Full Text Available Este artigo apresenta o debate teórico que sustenta a pesquisa de mestrado desenvolvida pelo autor. Tendo por base suas vivências em contextos de tradicionalismo gaúcho, o autor deste trabalho tem percebido a grande quantidade de homossexuais, ou indivíduos que se auto-denominam não-heterossexuais, integrando as atividades artísticas do Movimento Tradicionalista Gaúcho, ou a territorialidade tradicionalista. Interessado em investigar tal fenômeno, o autor tem desenvolvido o projeto de pesquisa “Os Espaços Paradoxais de Relações Homoeróticas na Territorialidade Tradicionalista”, sob orientação do prof. Dr. Benhur Pinós da Costa, no Programa de Pós-Graduação em Geografia (UFSM. Para que essa pesquisa seja realizada, levam-se em conta as relações de gênero e de sexualidade que estão envolvidas no tema. Dessa forma, por ainda se tratarem de temáticas tidas como insignificantes na sociedade em geral e marginalizadas no campo científico, para que o presente trabalho fosse empreendido, buscou-se amparo teórico nas geografias feministas e queer, segmentos contemporâneos da ciência geográfica.

  18. Micotoxinas e Micotoxicoses na Avicultura

    Directory of Open Access Journals (Sweden)

    Santurio JM

    2000-01-01

    Full Text Available Esta revisão tem como objetivo principal mostrar, baseado em dezenas de pesquisas realizadas, os efeitos tóxicos das micotoxinas aflatoxinas, tricotecenos, zealenona e fumonisinas sobre o desempenho das aves. O descobrimento das propriedades hepatotóxicas e hepatocarcinogênicas de algumas linhagens de Aspergillus flavus e A. parasiticus em perus, na Inglaterra, no início da década de 1960, seguida pela elucidação da estrutura de seus metabólitos tóxicos, as aflatoxinas, deu novo enfoque e prioridade para a pesquisa sobre micotoxinas. Análises de aflatoxinas realizadas no Laboratório de Análises Micotoxicológicas (LAMIC da Universidade Fedaral de Santa Maria, entre os anos de 1986 e janeiro de 2000, em 15.600 amostras de alimentos destinados principalmente ao consumo animal, demonstram que no milho analisado, 41,9% das amostras estavam contaminadas por aflatoxinas. Em surtos de aflatoxicose no campo, uma das características mais marcantes é a má absorção que se manifesta como partículas de ração mal digeridas na excreta das aves. Também observa-se, em frangos e poedeiras que recebem AFL, extrema palidez das mucosas e pernas. Dietas deficientes em riboflavina ou colecalciferol (vit. D tornaram frangos sensíveis, nos índices de desenvolvimento corporal, a concentrações muito baixas de AFL. O efeito aflatoxina nos frangos é maior na fase inicial de crescimento, ou seja, quando as aves ingeriram aflatoxina nos primeiros 21 dias de vida, e quanto maior o nível de stress do lote, menor a quantidade de AFL para afetar negativamente seu desempenho, seja na produção de carne ou de ovos. As principais micotoxinas do grupo dos tricotecenos são: toxina T-2; deoxynivalenol (DON; diacetoxyscirpenol (DAS, todas produzidas através de diversas espécies de fungos do gênero Fusarium. Além dos tricotecenos, o fusarium também pode produzir zearalenona e fumonisinas. Dessas fusarium-toxinas, somente toxina T-2 gera patologias s

  19. Fotografia na Imprensa: conflitos na câmara escura

    Directory of Open Access Journals (Sweden)

    José Lúcio da Silva Menezes

    2014-07-01

    Full Text Available Este artigo recupera o teor ideológico do discurso que a Revista Veja elaborou sobre a classe trabalhadora que emergiu no cenário brasileiro, no final da década de 1970. O destaque dado aos trabalhadores como temática central resgatada, deve-se aos movimentos grevistas por eles encetados, após anos de ocultamento de sua resistência sob a repressão da ditadura civil-militar (1964-1985. Com a rebeldia operária, as matérias a respeito deste grupo, na Revista,foram se tornando mais constantes e visíveis, pois já não era mais possível, para a Revista Veja, ignorar a existência da classe operária que, com a força insurgente das greves, ocupava as ruas do Brasil.

  20. Vpliv toplotnih mostov na porabo energije za ogrevanje na primeru osnovne šole

    OpenAIRE

    Megušar, Primož

    2015-01-01

    Na primeru Osnovne šole Dobrova sem preveril, kakšen vpliv imajo dejanski toplotni mostovi na porabo energije za ogrevanje. Iz načrtov stavbe sem evidentiral vse toplotne mostove, kateri vplivajo na porabo energije. Tem toplotnim mostovom sem nato v standardu SIST EN ISO 14683 poiskal ustrezne približke. Nato sem s programom TOST izvedel tri simulacije. V prvem primeru toplotnih mostov nisem upošteval. V drugem primeru sem toplotne mostove upošteval na poenostavljen način, v zadnjem primeru p...

  1. Na and K dependence of the Na/K pump in cystic fibrosis fibroblasts.

    OpenAIRE

    Reznik, V M; Schneider, J A; Mendoza, S A

    1981-01-01

    The Na and K dependence of the Na/K pump was measured in skin fibroblasts from patients with cystic fibrosis and age/sex-matched controls. Under basal conditions, there was no difference between control and cystic fibrosis cells in protein per cell, intracellular Na and K content, or Na/K pump activity (measured as ouabain-sensitive 86Rb uptake). There was no difference in the Na dependence of the Na/K pump between cystic fibrosis cells and control cells. In cells from patients with cystic fi...

  2. Modification of single Na+ channels by batrachotoxin.

    Science.gov (United States)

    Quandt, F N; Narahashi, T

    1982-11-01

    The modifications in the properties of voltage-gated Na+ channels caused by batrachotoxin were studied by using the patch clamp method for measuring single channel currents from excised membranes of N1E-115 neuroblastoma cells. The toxin-modified open state of the Na+ channel has a decreased conductance in comparison to that of normal Na+ channels. The lifetime of the modified open state is drastically prolonged, and channels now continue to open during a maintained depolarization so that the probability of a channel being open becomes constant. Modified and normal open states of Na+ channels coexist in batrachotoxin-exposed membrane patches. Unlike the normal condition, Na+ channels exposed to batrachotoxin open spontaneously at large negative potentials. These spontaneous openings apparently cause the toxin-induced increase in Na+ permeability which, in turn, causes membrane depolarization.

  3. Low-spin states of 23Na

    International Nuclear Information System (INIS)

    Bakkum, E.L.

    1987-01-01

    A study of 23 Na via the 22 Ne(p,γ) 23 Na and 23 Na(γ,γ) 23 Na reactions is presented. Only a limited number of resonances has been studied, selected on the basis of strong excitation of the lowest levels of which the spin was unknown. As a result the spins are now known of all levels of 23 Na with excitation energies up to 7 MeV, except for a few high-spin states which are too weakly excited in the decay of the known 22 Ne(p,γ) resonances. The mean lifetimes of the 23 Na levels at 4.43 and 7.89 MeV were found to be 350±70 and 220±17 attoseconds (1 attosecond = 10 -18 seconds) respectively. 97 refs.; 22 figs.; 12 tabs

  4. Opticheskije, magnitnyje i dielektricheskie svojstva opalovych matric s zapolneniem mezhefericheskih nanopolostej kristallicheskimi mul´tiferroikami, p´ezoelektricheskimi i segnetoelektricheskimi materialami

    Czech Academy of Sciences Publication Activity Database

    Samoylovich, M.I.; Rinkevich, A.B.; Bovtun, Viktor; Belyanin, A.F.; Kempa, Martin; Nuzhnyy, Dmitry; Tsvetkov, M.Ju.; Klescheva, S.M.

    2012-01-01

    Roč. 56, 1-2 (2012), s. 11-25 R&D Projects: GA ČR GAP204/12/0232 Institutional research plan: CEZ:AV0Z10100520 Keywords : nanocomposite * opal matrices * effective dielectric properties * multiferroics Subject RIV: BM - Solid Matter Physics ; Magnetism

  5. Modification of single Na+ channels by batrachotoxin.

    OpenAIRE

    Quandt, F N; Narahashi, T

    1982-01-01

    The modifications in the properties of voltage-gated Na+ channels caused by batrachotoxin were studied by using the patch clamp method for measuring single channel currents from excised membranes of N1E-115 neuroblastoma cells. The toxin-modified open state of the Na+ channel has a decreased conductance in comparison to that of normal Na+ channels. The lifetime of the modified open state is drastically prolonged, and channels now continue to open during a maintained depolarization so that the...

  6. PRIMERJAVA GEODETSKIH METOD NA ZAHTEVNEM GRADBENEM OBJEKTU

    OpenAIRE

    Reberčnik, Matic

    2017-01-01

    V projektni nalogi smo v uvodnih poglavjih predstavili različne načine izvajanja geodetskih meritev, ki jih v gradbeništvu uporabljamo pri analizi pomikov in deformacij gradbenih konstrukcij ter terena, na katerem so le-te postavljene. V nadaljevanju opisujemo terestične in GNSS (globalni navigacijski satelitski sistem) metode, ki smo jih uporabljali pri izvajanju meritev na izbranem premostitvenem objektu avtocestnega odseka v Sloveniji (zaradi varovanja podatkov ga imenujemo Objekt 1). Pod...

  7. Ionic dependence of active Na-K transport: clamping of cellular Na+ with monensin

    International Nuclear Information System (INIS)

    Haber, R.S.; Pressley, T.A.; Loeb, J.N.; Ismail-Beigi, F.

    1987-01-01

    The Na + ionophore monensin was used to study the Na + - and K + -dependence of ouabain-inhibitable 86 Rb + uptake in ARL 15 cells, a rat liver cell line. Graded concentrations of monensin rapidly induced incremental elevations of cellular Na + that were stable for up to 2 h. In experiments in which cellular Na + was thus clamped at various levels, the activation curve for ouabain-inhibitable 86 Rb + uptake as a function of intracellular Na + was found to be steepest near basal Na + levels (Hill coefficient /congruent/ 2.4), indicating that these cells can respond to relatively large changes in passive Na + entry by increasing the rate of Na-K pump function with only minimal increases in cellular Na + . Exposure of cells to monensin also permitted examination of the extracellular-K + dependence of ouabain inhibitable 86 Rb + uptake in presence of saturating intracellular Na + and yielded a Hill coefficient of ∼ 1.5. The rate of ATP hydrolysis calculated from measurements of the maximal rate of ouabain-inhibitable 86 Rb + uptake in intact cells was similar to the enzymatic V/sub max/ of the Na + -K + -ATPase in cell lysates, suggesting that the Na + -K + -ATPase activity in these broken-cell preparations closely reflects the functional transport capacity of the Na-K pump

  8. Fabrication of implanted $^{22}$Na targets

    CERN Multimedia

    2002-01-01

    A knowledge of the $^{22}$Na(p,$\\gamma$)$^{23}$ Mg reaction rate is of significant astrophysical interest. In order to complete previous studies of this reaction, radioactive $^{22}$Na targets of high purity are required. We ask for support to fabricate these targets via the implantation technique at ISOLDE GPS (off—line mode) using $^{22}$Na nuclides in an Al matrix produced in Nov. 1990 at the PSI (Zürich). The $^{22}$Na nuclides are released and ionized in a surface ionisation source, mass-analyzed at ISOLDE GPS, and implanted in a Ni-Ta backing and a C—foil in a special implantation setup.

  9. OGLAŠEVANJE NA FACEBOOKU V SLOVENIJI

    OpenAIRE

    Dobnik, Monja

    2013-01-01

    Danes so zahvaljujoč napredni mobilni tehnologiji družbena omrežja z nami na vsakem koraku. Facebook (FB) se po priljubljenosti uvršča v sam vrh družbenih omrežij in glede na to, da ga uporablja že več kot milijarda zemljanov, ponuja tudi odlične trg za oglaševanje. To so ugotovili tudi slovenski podjetniki. V diplomski nalogi je predstavljeno, kako na FB oglašujejo nekatera slovenska podjetja, s pomočjo spletnega vprašalnika pa je ugotovljeno tudi, kaj o oglasih na FB menijo njegovi uporabni...

  10. Na+ Recirculation and Isosmotic Transport

    DEFF Research Database (Denmark)

    Larsen, Erik Hviid; Møbjerg, N

    2006-01-01

    of the absorbate. Mathematical modeling reproducing bioelectric and hydrosmotic properties of small intestine and proximal tubule, respectively, predicts a significant range of observations such as isosmotic transport, hyposmotic transport, solvent drag, anomalous solvent drag, the residual hydraulic permeability...... external baths. Hyperosmolarity of lis is governed by the hydraulic permeability of the apical plasma membrane and tight junction with 6-7 mOsm in small intestine and transport demands a Na(+) recirculation of 50-70% in small intestine but might be barely...... measurable in proximal tubule. The model fails to reproduce a certain type of observations: The reduced volume absorption at transepithelial osmotic equilibrium in AQP1 knockout mice, and the stimulated water absorption by gallbladder in diluted external solutions. Thus, it indicates cellular regulation...

  11. O consumo na vida digital

    Directory of Open Access Journals (Sweden)

    Iuri Yudi Furukita Baptista

    2016-02-01

    Full Text Available O modelo de consumo não possui as mesmas características sempre: suas relações, motivações, formatos, espaços, interesses e atividades são construções sociais que se modificam atreladas ao cenário econômico, político e tecnológico. O presente trabalho repassa o surgimento da sociedade do consumidor para então conjecturar sobre as propriedades distintivas do consumo na vida digital. O que se defende ao final é que o consumidor já não se restringe ao papel de consumir.

  12. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart

    Science.gov (United States)

    Shattock, Michael J; Ottolia, Michela; Bers, Donald M; Blaustein, Mordecai P; Boguslavskyi, Andrii; Bossuyt, Julie; Bridge, John H B; Chen-Izu, Ye; Clancy, Colleen E; Edwards, Andrew; Goldhaber, Joshua; Kaplan, Jack; Lingrel, Jerry B; Pavlovic, Davor; Philipson, Kenneth; Sipido, Karin R; Xie, Zi-Jian

    2015-01-01

    This paper is the third in a series of reviews published in this issue resulting from the University of California Davis Cardiovascular Symposium 2014: Systems approach to understanding cardiac excitation–contraction coupling and arrhythmias: Na+ channel and Na+ transport. The goal of the symposium was to bring together experts in the field to discuss points of consensus and controversy on the topic of sodium in the heart. The present review focuses on cardiac Na+/Ca2+ exchange (NCX) and Na+/K+-ATPase (NKA). While the relevance of Ca2+ homeostasis in cardiac function has been extensively investigated, the role of Na+ regulation in shaping heart function is often overlooked. Small changes in the cytoplasmic Na+ content have multiple effects on the heart by influencing intracellular Ca2+ and pH levels thereby modulating heart contractility. Therefore it is essential for heart cells to maintain Na+ homeostasis. Among the proteins that accomplish this task are the Na+/Ca2+ exchanger (NCX) and the Na+/K+ pump (NKA). By transporting three Na+ ions into the cytoplasm in exchange for one Ca2+ moved out, NCX is one of the main Na+ influx mechanisms in cardiomyocytes. Acting in the opposite direction, NKA moves Na+ ions from the cytoplasm to the extracellular space against their gradient by utilizing the energy released from ATP hydrolysis. A fine balance between these two processes controls the net amount of intracellular Na+ and aberrations in either of these two systems can have a large impact on cardiac contractility. Due to the relevant role of these two proteins in Na+ homeostasis, the emphasis of this review is on recent developments regarding the cardiac Na+/Ca2+ exchanger (NCX1) and Na+/K+ pump and the controversies that still persist in the field. PMID:25772291

  13. Analiza utjecaja stabilizatora na određivanje elemenata vanjske orijentacije kamere na bespilotnoj letjelici

    OpenAIRE

    Gašparović, Mateo; Gajski, Dubravko

    2016-01-01

    U radu su prikazani i interpretirani rezultati analize utjecaja stabilizatora kamere na određivanje elemenata vanjske orijentacije na bespilotnim letjelicama. Riječ je o 3-osnom stabilizatoru baziranom na elektromotorima bez četkica. Prikazan je i objašnjen koncept rada stabilizatora kamera na bespilotnim letjelicama. Za potrebe rada stabilizator je unaprijeđen upotrebom drugog inercijalnog mjernog uređaja (IMU). Provedena su dva testiranja stabilizatora upotrebom jednog i dva inercijalna mje...

  14. Na+,K+-ATPase Na+ affinity in rat skeletal muscle fiber types

    DEFF Research Database (Denmark)

    Kristensen, Michael; Juel, Carsten

    2010-01-01

    Previous studies in expression systems have found different ion activation of the Na(+)/K(+)-ATPase isozymes, which suggest that different muscles have different ion affinities. The rate of ATP hydrolysis was used to quantify Na(+),K(+)-ATPase activity, and the Na(+) affinity of Na(+),K(+)-ATPase......Previous studies in expression systems have found different ion activation of the Na(+)/K(+)-ATPase isozymes, which suggest that different muscles have different ion affinities. The rate of ATP hydrolysis was used to quantify Na(+),K(+)-ATPase activity, and the Na(+) affinity of Na......(+),K(+)-ATPase was studied in total membranes from rat muscle and purified membranes from muscle with different fiber types. The Na(+) affinity was higher (K(m) lower) in oxidative muscle compared with glycolytic muscle and in purified membranes from oxidative muscle compared with glycolytic muscle. Na......(+),K(+)-ATPase isoform analysis implied that heterodimers containing the beta(1) isoform have a higher Na(+) affinity than heterodimers containing the beta(2) isoform. Immunoprecipitation experiments demonstrated that dimers with alpha(1) are responsible for approximately 36% of the total Na,K-ATPase activity. Selective...

  15. Exploration of NaVOPO4 as a cathode for a Na-ion battery.

    Science.gov (United States)

    Song, Jie; Xu, Maowen; Wang, Long; Goodenough, John B

    2013-06-11

    Monoclinic NaVOPO4 is explored as a cathode material for a sodium ion battery. It exhibits electrochemical activity operating at an average potential of 3.6 V (vs. Na(+)/Na) and delivers a reversible capacity of 90 mA h g(-1) at 1/15 C.

  16. Study of the Na-C-O and Na-H-O ternary systems in the sodium rich corner

    International Nuclear Information System (INIS)

    Maupre, J.-P.

    1978-02-01

    The purpose of this study is to provide a contribution to the understanding of the sodium - carbon - oxygen and sodium - hydrogen - oxygen ternary systems in the sodium rich corner. In order to do this the Na-NaH-Na 2 O-NaOH phase diagram was completed and the Na-Na 2 O-Na 2 CO 3 -C phase diagram was outlined. This work is made up of two parts. The first is devoted to a critical literature survey essential to establish correct phase diagrams. The second is an experimental study followed by a discussion collating our finding to the literary data. The basic experimental technique used is differential thermal analysis (DTA) but it has been completed by quenching, X-ray and chemical analysis methods. The proposed phase diagrams imply that Na-NaH-Na 2 O-NaOH and Na-Na 2 O-Na 2 CO 3 -C systems are reciprocal ternary systems. Temperatures of stable pairs reversal are respectively 410 and 690 0 C. The stable pairs are Na-NaOH and Na-Na 2 CO 3 at elevated temperature, Na 2 O-NaH and Na 2 O-C at low temperature [fr

  17. OGLAŠEVANJE NA DRUŽBENIH OMREŽJIH NA PRIMERU FACEBOOKA

    OpenAIRE

    Novak, Martina

    2012-01-01

    V diplomskem delu obravnavamo družbene medije kot novo priložnost za promocijo in oglaševanje podjetij. Spoznali smo družbena omrežja na splošno in nekaj teh, ki jih uporabljamo tudi v Sloveniji na kratko predstavili. Podrobneje smo se osredotočili na družbeno omrežje Facebook, predvsem na samo spletno stran, njen izgled in storitve, ki jih ponuja uporabnikom. V nalogi je podrobneje opisan Facebook kot orodje za uporabo oglaševanja. Spoznali smo brezplačne in plačljive načine promocije in ogl...

  18. Extracellular Na+ levels regulate formation and activity of the NaX/alpha1-Na+/K+-ATPase complex in neuronal cells.

    Directory of Open Access Journals (Sweden)

    Emmanuelle eBerret

    2014-12-01

    Full Text Available MnPO neurons play a critical role in hydromineral homeostasis regulation by acting as sensors of extracellular sodium concentration ([Na+]out. The mechanism underlying Na+-sensing involves Na+-flow through the NaX channel, directly regulated by the Na+/K+-ATPase α1-isoform which controls Na+-influx by modulating channel permeability. Together, these two partners form a complex involved in the regulation of intracellular sodium ([Na+]in. Here we aim to determine whether environmental changes in Na+ could actively modulate the NaX/Na+/K+-ATPase complex activity.We investigated the complex activity using patch-clamp recordings from rat MnPO neurons and Neuro2a cells. When the rats were fed with a high-salt-diet, or the [Na+] in the culture medium was increased, the activity of the complex was up-regulated. In contrast, drop in environmental [Na+] decreased the activity of the complex. Interestingly under hypernatremic condition, the colocalization rate and protein level of both partners were up-regulated. Under hyponatremic condition, only NaX protein expression was increased and the level of NaX/Na+/K+-ATPase remained unaltered. This unbalance between NaX and Na+/K+-ATPase pump proportion would induce a bigger portion of Na+/K+-ATPase-control-free NaX channel. Thus we suggest that hypernatremic environment increases NaX/Na+/K+-ATPase α1-isoform activity by increasing the number of both partners and their colocalization rate, whereas hyponatremic environment down-regulates complex activity via a decrease in the relative number of NaX channels controlled by the pump.

  19. K+ congeners that do not compromise Na+ activation of the Na+,K+-ATPase

    DEFF Research Database (Denmark)

    Mahmmoud, Yasser A; Kopec, Wojciech; Khandelia, Himanshu

    2015-01-01

    to no antagonism to cytoplasmic Na(+) activation. Na(+),K(+)-ATPase structures revealed a previously undescribed rotamer transition of the hydroxymethyl side chain of the absolutely conserved Thr(772) of the α-subunit. The side chain contributes its hydroxyl to Na(+) in site I in the E1 form and rotates......The Na(+),K(+)-ATPase is essential for ionic homeostasis in animal cells. The dephosphoenzyme contains Na(+) selective inward facing sites, whereas the phosphoenzyme contains K(+) selective outward facing sites. Under normal physiological conditions, K(+) inhibits cytoplasmic Na(+) activation...... to contribute its methyl group toward K(+) in the E2 form. Molecular dynamics simulations to the E1·AlF4 (-)·ADP·3Na(+) structure indicated that 1) bound organic cations differentially distorted the ion binding sites, 2) the hydroxymethyl of Thr(772) rotates to stabilize bound Form(+) through water molecules...

  20. Crystal structure of Na+, K(+)-ATPase in the Na(+)-bound state.

    Science.gov (United States)

    Nyblom, Maria; Poulsen, Hanne; Gourdon, Pontus; Reinhard, Linda; Andersson, Magnus; Lindahl, Erik; Fedosova, Natalya; Nissen, Poul

    2013-10-04

    The Na(+), K(+)-adenosine triphosphatase (ATPase) maintains the electrochemical gradients of Na(+) and K(+) across the plasma membrane--a prerequisite for electrical excitability and secondary transport. Hitherto, structural information has been limited to K(+)-bound or ouabain-blocked forms. We present the crystal structure of a Na(+)-bound Na(+), K(+)-ATPase as determined at 4.3 Å resolution. Compared with the K(+)-bound form, large conformational changes are observed in the α subunit whereas the β and γ subunit structures are maintained. The locations of the three Na(+) sites are indicated with the unique site III at the recently suggested IIIb, as further supported by electrophysiological studies on leak currents. Extracellular release of the third Na(+) from IIIb through IIIa, followed by exchange of Na(+) for K(+) at sites I and II, is suggested.

  1. LEITURA E LEITURA NA UNIVERSIDADE

    Directory of Open Access Journals (Sweden)

    Profª Drª Márcia A. G. Molina

    2015-12-01

    Full Text Available O texto apresenta uma discussão acerca da leitura, traçando, primeiramente, um percurso histórico dessa questão, iniciando-se no XIX aqui no Brasil.. Na sequência, aponta-se para a importância daquele que trabalha com a leitura ter paixão por ela, para que possa formar sujeitos também apaixonados pelo ato de ler. Continua mostrando os tipos de leitura, de acordo com FREIRE (1989, KOCK e ELIAS (2006 e apontando as atuais orientações para os procedimentos de leitura de um texto, baseados em KLEIMAN (2002. Conclui-se que, para formar o bom leitor, entendido como aquele que lê o não-dito e caminha para além da paráfrase reprodutiva, deve-se: ter paixão pela leitura, orientar os estudantes para essa prática, estabelecendo-se objetivos de leitura e reconhecer as estratégias que compreendem essa atividade.

  2. Necessidades da vida na morte

    Directory of Open Access Journals (Sweden)

    Denise Stefanoni Combinato

    2017-04-01

    Full Text Available Em função do envelhecimento populacional e aumento de doenças crônicas não transmissíveis, a Estratégia Saúde da Família (ESF tem se deparado com as necessidades das pessoas em processo de morte. A partir da análise do trabalho de profissionais da saúde que cuidaram de pessoas em processo de morte, o objetivo deste artigo é discutir as necessidades de saúde nesse processo, a fim de subsidiar o trabalho com essa população, especialmente na Atenção Primária à Saúde. Participaram da entrevista, após serem selecionados por dois questionários, onze profissionais (enfermeiros e médicos da ESF de Campinas/SP. A análise de dados foi pautada no referencial teórico-metodológico da Psicologia histórico-cultural. Como resultado, tem-se que as necessidades dos pacientes e familiares não são restritas ao momento de vida (proximidade da morte, mas referem-se, também, às condições de vulnerabilidade social.

  3. Terapia de linguagem na afasia

    Directory of Open Access Journals (Sweden)

    Mauro Spinelli

    1977-12-01

    Full Text Available A terapia da linguagem na afasia foi estudada em 15 pacientes, 8 do sexo masculino e 7 do sexo feminino; a idade variou de menos de 10 anos a mais de 50 anos; em 11 casos a afasia era sequela de acidente vascular cerebral e, em 4, de traumatismo crânio-encefálico. Quanto ao tipo de afasia, 5 pacientes apresentavam déficits predominantemente de expressão e 10 apresentavam déficits receptivos e expressivos em graus equiparáveis. Em 6 casos a terapia foi iniciada dentro dos 3 primeiros meses de instalação do quadro; nos restantes foi iniciada mais tardiamente. Dos 15 pacientes, 11 apresentaram evolução satisfatória, a qual não depndeu do grau de afasia, do tipo de afasia, da idade do paciente, do tipo de patologia e do intervalo entre a instalação do quadro afásico e o início da terapia. A terapia da linguagem no paciente afásico é efetiva, o prognóstico não pode ser feito a priori. Somente a evolução do caso com sua retestagem criteriosa poderá dar dados realmente úteis para se falar em evolução.

  4. Liquido cefalorraquiano na cisticercose encefalica

    Directory of Open Access Journals (Sweden)

    João Baptista dos Reis

    1979-06-01

    Full Text Available Foi feito um estudo do comportamento do líquido cefalorraquiano (LCR na cisticercose encefálica, com base em 656 observações retiradas de um material constituído por 120.000 exames de pacientes neurológicos e psiquiátricos, reunidas em 35 anos de trabalho. Com base nos casos comprovados por necrópsia ou cirurgia foram descritas as alterações do LCR. O estudo consecutivo de amostras de LCR obtidas em anos sucessivos, durante o decurso da doença, mostrou a persistência das alterações em numerosos casos, mesmo depois de 4 a 18 anos de observação. A reação de fixação de complemento para cisticerco permaneceu positiva durante todos estes anos. Foram também apreciadas as modificações do LCR em casos de cisticercose sub-cutânea e do globo ocular e em casos com cisticercos calcificados no encéfalo.

  5. Barroco: A tempestade na Biblioteca

    Directory of Open Access Journals (Sweden)

    Diego Cervelin

    2008-10-01

    Full Text Available http://dx.doi.org/10.5007/1984-784x.2008v8n12p167 Desde que Heinrich Wölfflin, nos últimos vinte anos do século XIX, se interessou por trazer à tona as formas arquitetônicas do século XVII conferindo-lhes caráter autônomo de estilo histórico determinável, não é nenhuma novidade que os estudos sobre o barroco pudessem polarizar – quase sempre em um tom colérico – os pesquisadores da arte e da cultura. Em terras do Brasil, não chega a ser de todo descabido recordar a severíssima crítica operada por Sérgio Buarque de Holanda em Raízes do Brasil. O livro, que pretende detectar a avalanche de equívocos que teria povoado o passado nacional com as vistas voltadas para a concretização de um projeto de emancipação e progresso na linha da história brasileira, apresenta em seu quarto capítulo uma impugnação explícita ao passado colonial.

  6. Barroco: A tempestade na Biblioteca

    Directory of Open Access Journals (Sweden)

    Diego Cervelin

    2008-12-01

    Full Text Available Desde que Heinrich Wölfflin, nos últimos vinte anos do século XIX, se interessou por trazer à tona as formas arquitetônicas do século XVII conferindo-lhes caráter autônomo de estilo histórico determinável, não é nenhuma novidade que os estudos sobre o barroco pudessem polarizar – quase sempre em um tom colérico – os pesquisadores da arte e da cultura. Em terras do Brasil, não chega a ser de todo descabido recordar a severíssima crítica operada por Sérgio Buarque de Holanda em Raízes do Brasil. O livro, que pretende detectar a avalanche de equívocos que teria povoado o passado nacional com as vistas voltadas para a concretização de um projeto de emancipação e progresso na linha da história brasileira, apresenta em seu quarto capítulo uma impugnação explícita ao passado colonial.

  7. Gasotransmitters: Novel regulators of epithelial Na+ transport?

    Directory of Open Access Journals (Sweden)

    Mike eAlthaus

    2012-04-01

    Full Text Available The vectorial transport of Na+ across epithelia is crucial for the maintenance of Na+ and water homeostasis in organs such as the kidneys, lung or intestine. Dysregulated Na+ transport processes are associated with various human diseases such as hypertension, the salt-wasting syndrome pseudohypoaldosteronism type 1, pulmonary edema, cystic fibrosis or intestinal disorders, which indicate that a precise regulation of epithelial Na+ transport is essential. Novel regulatory signaling molecules are gasotransmitters. There are currently three known gasotransmitters: nitric oxide (NO, carbon monoxide (CO and hydrogen sulfide (H2S. These molecules are endogenously produced in mammalian cells by specific enzymes and have been shown to regulate various physiological processes. There is a growing body of evidence, which indicates that gasotransmitters may also regulate Na+ transport across epithelia. This review will summarize the available data concerning NO, CO and H2S dependent regulation of epithelial Na+ transport processes and will discuss whether or not these mediators can be considered as true physiological regulators of epithelial Na+ transport biology.

  8. NMR studies on Na+ transport in Synechococcus PCC 6311

    Science.gov (United States)

    Nitschmann, W. H.; Packer, L.

    1992-01-01

    The freshwater cyanobacterium Synechococcus PCC 6311 is able to adapt to grow after sudden exposure to salt (NaCl) stress. We have investigated the mechanism of Na+ transport in these cells during adaptation to high salinity. Na+ influx under dark aerobic conditions occurred independently of delta pH or delta psi across the cytoplasmic membrane, ATPase activity, and respiratory electron transport. These findings are consistent with the existence of Na+/monovalent anion cotransport or simultaneous Na+/H+ +anion/OH- exchange. Na+ influx was dependent on Cl-, Br-, NO3-, or NO2-. No Na+ uptake occurred after addition of NaI, NaHCO3, or Na2SO4. Na+ extrusion was absolutely dependent on delta pH and on an ATPase activity and/or on respiratory electron transport. This indicates that Na+ extrusion via Na+/H+ exchange is driven by primary H+ pumps in the cytoplasmic membrane. Cells grown for 4 days in 0.5 m NaCl medium, "salt-grown cells," differ from control cells by a lower maximum velocity of Na+ influx and by lower steady-state ratios of [Na+]in/[Na+]out. These results indicate that cells grown in high-salt medium increase their capacity to extrude Na+. During salt adaptation Na+ extrusion driven by respiratory electron transport increased from about 15 to 50%.

  9. Na/K pump inactivation, subsarcolemmal Na measurements, and cytoplasmic ion turnover kinetics contradict restricted Na spaces in murine cardiac myocytes

    OpenAIRE

    Lu, Fang-Min; Hilgemann, Donald W.

    2017-01-01

    The Na/K pump exports cytoplasmic Na ions while importing K ions, and its activity is thought to be affected by restricted intracellular Na diffusion in cardiac myocytes. Lu and Hilgemann find instead that the pump can enter an inactivated state and that inactivation can be relieved by cytoplasmic Na.

  10. Fotokromne tiskarske barve na osnovi resorufina

    OpenAIRE

    Drnovšek, Petra

    2017-01-01

    Pametni materiali pod vplivom zunanjega dejavnika na predvidljiv in navadno uporaben način spremenijo svoje lastnosti. Takšni materiali so fotokatalitsko aktivne tiskarske barve, pri katerih se pod vplivom ultravijoličnega sevanja (v nadaljevanju UV) in/ali vidne svetlobe sproži fotokataliza, čemur sledi sprememba barve. Ena izmed možnih aplikacij fotokatalitsko aktivnih tiskarskih barv je ta, da uporabnika s spremembo barve opozarjajo na količino izpostavljenosti potencialno škodljivemu UV s...

  11. Pretpostavke za valorizaciju zapisa na elektronskim medijima

    OpenAIRE

    Eržišnik, Davorin

    1999-01-01

    U napisu se raspravlja o razlozima za valorizaciju zapisa na elektronskim medijima. Oni su ujedno i pretpostavke za tu valorizaciju, jer da bi ona uoće provodila, moraju postojati i razlozi. Istraživanje se bazira na usporedbi izmedju tih zapisa s jedne strane te klasičnih dokumenata i mikrofilmskih zapisa, s druge. Zaključuje se da u odnosu na tu drugu stranu, elektronski zapisi moraju imati i neke dodatne prednosti i kvalitete. U protivnom, ni ta valorizacija ne bi imala smisla.

  12. Naša eko hrana

    OpenAIRE

    Kelnerić, Tatjana

    2013-01-01

    Zdrav način življenja trajna je zadaća održivog razvoja i može se reći da ne postoji dobna granica za početak takvog načina života. U tom kontekstu neizbježno je da cilj svakog odgojno-obrazovnog rada, bilo da je riječ o projektu ili svakodnevici jedne odgojno-obrazovne skupine u dječjem vrtiću, mora biti usmjeren na čisto i zdravo okruženje, neposredan kontakt djeteta s prirodom, pravilnu prehranu i kretanje.

  13. VPLIV TEHNOLOŠKIH SPREMEMB NA GLOBALIZACIJO

    OpenAIRE

    Mohar, Nives

    2015-01-01

    Magistrsko delo z naslovom »Vpliv tehnoloških dejavnikov na globalizacijo« zajema dve večji področji ekonomske teorije – tehnologijo in globalizacijo. Namen magistrskega dela je analizirati odnose med tehnološkimi spremembami, gospodarsko rastjo in globaliziranostjo držav. Teoretični del smo razdelili na obravnavo tehnologije in globalizacije. Najprej smo predstavili pojme, ki se navezujejo na tehnologijo, nato smo prikazali mesto tehnologije skozi zgodovino ekonomske teorije in predstavi...

  14. Na+,K+ pumpen vedbliver at overraske

    DEFF Research Database (Denmark)

    Vilsen, Bente

    2008-01-01

    This article provides an overview of news about the Na+,K+ pump, an indispensable enzyme whose protein structure has been described in a recent article in Nature, 50 years after its discovery. In combination with mutational analysis, the structure reveals the binding pocket for the K+ ions...... and the regulation of Na+ transport by a strategically located C-terminus of the protein. Focus is also on the pathophysiology of two neurological disorders, familial hemiplegic migraine and rapid-onset dystonia-parkinsonism, recently shown to be caused by mutations in the Na+,K+-ATPase. Udgivelsesdato: may 19...

  15. Myocardial Na,K-ATPase: Clinical aspects

    Science.gov (United States)

    Kjeldsen, Keld

    2003-01-01

    The specific binding of digitalis glycosides to Na,K-ATPase is used as a tool for Na,K-ATPase quantification with high accuracy and precision. In myocardial biopsies from patients with heart failure, total Na,K-ATPase concentration is decreased by around 40%; a correlation exists between a decrease in heart function and a decrease in Na,K-ATPase concentration. During digitalization, around 30% of remaining pumps are occupied by digoxin. Myocardial Na,K-ATPase is also influenced by other drugs used for the treatment of heart failure. Thus, potassium loss during diuretic therapy has been found to reduce myocardial Na,K-ATPase, whereas angiotensin-converting enzyme inhibitors may stimulate Na,K pump activity. Furthermore, hyperaldosteronism induced by heart failure has been found to decrease Na,K-ATPase activity. Accordingly, treatment with the aldosterone antagonist, spironolactone, may also influence Na,K-ATPase activity. The importance of Na,K pump modulation with heart disease, inhibition in digitalization and other effects of medication should be considered in the context of sodium, potassium and calcium regulation. It is recommended that digoxin be administered to heart failure patients who, after institution of mortality-reducing therapy, still have heart failure symptoms, and that the therapy be continued if symptoms are revealed or reduced. Digitalis glycosides are the only safe inotropic drugs for oral use that improve hemodynamics in heart failure. An important aspect of myocardial Na,K pump affection in heart disease is its influence on extracellular potassium (Ke) homeostasis. Two important aspects should be considered: potassium handling among myocytes, and effects of potassium entering the extracellular space of the heart via the bloodstream. It should be noted that both of these aspects of Ke homeostasis are affected by regulatory aspects, eg, regulation of the Na,K pump by physiological and pathophysiological conditions, as well as by medical

  16. Prepoznavanje spolnega nadlegovanja na delovnem mestu v zdravstvu

    OpenAIRE

    Lešnik, Tina

    2013-01-01

    Diplomsko delo predstavlja problem spolnega nadlegovanja na delovnem mestu na podlagi slovenske in tuje teorije ter se osredotoča na ugotavljanje pojava spolnega nadlegovanja na delovnem mestu v zdravstvu. Izhodišča: Dosedanje raziskave nasilja in spolnega nadlegovanja na delovnem mestu kažejo, da so zdravstveni delavci le temu izpostavljeni bolj kot delavci v drugih panogah. V okviru diplomskega dela smo raziskali prepoznavanje in pojavnost spolnega nadlegovanja na delovnem mestu med štu...

  17. Glutathionylation-Dependence of Na+-K+-Pump Currents Can Mimic Reduced Subsarcolemmal Na+ Diffusion

    Science.gov (United States)

    Garcia, Alvaro; Liu, Chia-Chi; Cornelius, Flemming; Clarke, Ronald J.; Rasmussen, Helge H.

    2016-01-01

    The existence of a subsarcolemmal space with restricted diffusion for Na+ in cardiac myocytes has been inferred from a transient peak electrogenic Na+-K+ pump current beyond steady state on reexposure of myocytes to K+ after a period of exposure to K+-free extracellular solution. The transient peak current is attributed to enhanced electrogenic pumping of Na+ that accumulated in the diffusion-restricted space during pump inhibition in K+-free extracellular solution. However, there are no known physical barriers that account for such restricted Na+ diffusion, and we examined if changes of activity of the Na+-K+ pump itself cause the transient peak current. Reexposure to K+ reproduced a transient current beyond steady state in voltage-clamped ventricular myocytes as reported by others. Persistence of it when the Na+ concentration in patch pipette solutions perfusing the intracellular compartment was high and elimination of it with K+-free pipette solution could not be reconciled with restricted subsarcolemmal Na+ diffusion. The pattern of the transient current early after pump activation was dependent on transmembrane Na+- and K+ concentration gradients suggesting the currents were related to the conformational poise imposed on the pump. We examined if the currents might be accounted for by changes in glutathionylation of the β1 Na+-K+ pump subunit, a reversible oxidative modification that inhibits the pump. Susceptibility of the β1 subunit to glutathionylation depends on the conformational poise of the Na+-K+ pump, and glutathionylation with the pump stabilized in conformations equivalent to those expected to be imposed on voltage-clamped myocytes supported this hypothesis. So did elimination of the transient K+-induced peak Na+-K+ pump current when we included glutaredoxin 1 in patch pipette solutions to reverse glutathionylation. We conclude that transient K+-induced peak Na+-K+ pump current reflects the effect of conformation-dependent β1 pump subunit

  18. Altered Na+ transport after an intracellular alpha-subunit deletion reveals strict external sequential release of Na+ from the Na/K pump.

    Science.gov (United States)

    Yaragatupalli, Siddhartha; Olivera, J Fernando; Gatto, Craig; Artigas, Pablo

    2009-09-08

    The Na/K pump actively exports 3 Na(+) in exchange for 2 K(+) across the plasmalemma of animal cells. As in other P-type ATPases, pump function is more effective when the relative affinity for transported ions is altered as the ion binding sites alternate between opposite sides of the membrane. Deletion of the five C-terminal residues from the alpha-subunit diminishes internal Na(+) (Na(i)(+)) affinity approximately 25-fold [Morth et al. (2007) Nature 450:1043-1049]. Because external Na(+) (Na(o)(+)) binding is voltage-dependent, we studied the reactions involving this process by using two-electrode and inside-out patch voltage clamp in normal and truncated (DeltaKESYY) Xenopus-alpha1 pumps expressed in oocytes. We observed that DeltaKESYY (i) decreased both Na(o)(+) and Na(i)(+) apparent affinities in the absence of K(o)(+), and (ii) did not affect apparent Na(o)(+) affinity at high K(o)(+). These results support a model of strict sequential external release of Na(+) ions, where the Na(+)-exclusive site releases Na(+) before the sites shared with K(+) and the DeltaKESYY deletion only reduces Na(o)(+) affinity at the shared sites. Moreover, at nonsaturating K(o)(+), DeltaKESYY induced an inward flow of Na(+) through Na/K pumps at negative potentials. Guanidinium(+) can also permeate truncated pumps, whereas N-methyl-D-glucamine cannot. Because guanidinium(o)(+) can also traverse normal Na/K pumps in the absence of both Na(o)(+) and K(o)(+) and can also inhibit Na/K pump currents in a Na(+)-like voltage-dependent manner, we conclude that the normal pathway transited by the first externally released Na(+) is large enough to accommodate guanidinium(+).

  19. Painful Na-channelopathies: an expanding universe.

    Science.gov (United States)

    Waxman, Stephen G

    2013-07-01

    The universe of painful Na-channelopathies--human disorders caused by mutations in voltage-gated sodium channels--has recently expanded in three dimensions. We now know that mutations of sodium channels cause not only rare genetic 'model disorders' such as inherited erythromelalgia and channelopathy-associated insensitivity to pain but also common painful neuropathies. We have learned that mutations of NaV1.8, as well as mutations of NaV1.7, can cause painful Na-channelopathies. Moreover, recent studies combining atomic level structural models and pharmacogenomics suggest that the goal of genomically guided pain therapy may not be unrealistic. Copyright © 2013 Elsevier Ltd. All rights reserved.

  20. Erythrocyte 22Na+ influx in hypertension

    International Nuclear Information System (INIS)

    Shalev, O.; Eaton, J.W.; Ben-Ishay, D.

    1984-01-01

    We assessed 22Na+ uptake by erythrocytes (RBC) from 38 individuals with essential hypertension and 37 healthy controls. All subjects were male, white, non-obese and with normal renal function, obviating sex, race, hormonal, ponderal and renal factors known to influence RBC Na+ handling. The mean +/- sem 22Na+ uptake of the patients was 284 +/- 16 mumole/liter RBC/hour while that of normal controls was 249 +/- 11 mumole/liter RBC/hour; although the difference reached borderline significance, individual values showed considerable overlap. Consequently, in our population, RBC 22Na+ uptake is not a reliable marker for essential hypertension. We believe that previous studies should be reassessed with regard to patients' characteristics and future studies employ rigorous criteria in selection of subjects

  1. Na+-H+ exchange and Na+-dependent transport systems in streptozotocin diabetic rat kidneys

    International Nuclear Information System (INIS)

    El-Seifi, S.; Freiberg, J.M.; Kinsella, F.J.; Cheng, L.; Sacktor, B.

    1987-01-01

    The streptozotocin-induced diabetic rat was used to test the hypothesis that Na + -H + exchange activity in the proximal tubule luminal membrane would be increased in association with renal hypertrophy, altered glomerular hemodynamics, enhanced filtered load and tubular reabsorption of 22 Na + , and stimulated 22 Na= pump activity in the basolateral membrane, previously reported characteristics of this experimental animal model. Amiloride-sensitive H + gradient-dependent Na + uptake and Na + gradient-dependent H + flux were increased in brush-border membrane vesicles from the streptozotocin-treated animals. Na + gradient-dependent uptakes of phosphate, D-glucose, L-proline, and myoinositol were decreased in the drug-induced diabetic animals. These membrane transport alterations were not found when the streptozotocin-diabetic animals were treated with insulin

  2. Perfil nutricional na artrite reumatoide

    Directory of Open Access Journals (Sweden)

    Rachel Simone Maccarini Zarpellon

    2014-01-01

    Full Text Available Objetivo: Estudar o perfil nutricional de pacientes com artrite reumatoide (AR. Métodos: Estudo transversal observacional de 102 pacientes com AR. Os pacientes foram estudados para dados clínicos, demográficos, sorológicos, atividade de doença e perfil nutricional. Neste último incluiu-se a medida do índice de massa corporal (IMC, relação quadril/cintura, pregas cutâneas bicipitais (PCB e sua adequação; prega cutânea tricipital (PCT e sua adequação e circunferência muscular do braço (CMB e sua adequação. Estudos de associação foram feitos usando os testes de Fisher e qui-quadrado para dados nominais e teste t não pareado e Mann Whitney para dados numéricos. Para cálculo de correlação usou-se o teste de Spearman. Resultado: Na amostra existiam 14/102 homens e 88/102 mulheres com idade média de 52,1 ± 11,5 anos e duração média de doença de 10,6 ± 7,4 anos. A relação cintura/quadril média era de 0,92 ± 0,07. De acordo com IMC, 30,3% tinham peso normal e 65,5% tinham peso acima do normal. De acordo com PCB, 74,5% eram normais e 25,5% tinham depleção; de acordo com a PCT, 83,3% eram normais e 16,7% tinham depleção. Associação de variáveis nutricionais com gênero, fator reumatoide, nódulos e atividade da doença não mostraram diferenças (p = NS exceto, por uma relação cintura/quadril menor em indivíduos com nódulos (p = 0,02 e uma correlação modesta da PCT com a duração de doença (p = 0,02; R = 0,22; 95% IC = 0,01-0,40. Conclusão: Existe uma alta prevalência de sobrepeso e obesidade em artrite reumatoide e uma pequena frequência de depleção muscular.

  3. Glutathionylation-Dependence of Na+-K+-Pump Currents Can Mimic Reduced Subsarcolemmal Na+ Diffusion

    OpenAIRE

    Garcia, Alvaro; Liu, Chia-Chi; Cornelius, Flemming; Clarke, Ronald?J.; Rasmussen, Helge?H.

    2016-01-01

    The existence of a subsarcolemmal space with restricted diffusion for Na+ in cardiac myocytes has been inferred from a transient peak electrogenic Na+-K+ pump current beyond steady state on reexposure of myocytes to K+ after a period of exposure to K+-free extracellular solution. The transient peak current is attributed to enhanced electrogenic pumping of Na+ that accumulated in the diffusion-restricted space during pump inhibition in K+-free extracellular solution. However, there are no know...

  4. Theoretical study of Na(4p2P)+Na(3s2S) and Cd(5p3P0)+Na(3s2S) collisions and their role in the energy transfer between Cd* and Na

    International Nuclear Information System (INIS)

    Magnier, S.; Pisa Univ.; Angeli, C.; Granucci, G.; Masnou-Seeuws, F.; Allegrini, M.; Pisa Univ.; Persico, M.

    1997-01-01

    We have computed the cross sections for the energy transfer process Cd(5p 3 P 0 ) + Na(3s 2 S) →Cd(5s 1 S) + Na(4p 2 P) and for the state changing collision Na(4p 2 P) + Na(3s 2 S)→Na(3d 2 D) + Na(3s 2 S), based on theoretical interaction potentials for the NaCd and Na 2 systems, respectively. Our calculations shed light on the interpretation of experiments with laser excited Na+Cd vapour mixtures. It turns out that Cd(5p 3 P 0 ), in rapid equilibrium with the doorway state Cd(5p 3 P 1 ), efficiently transfers energy to Na, populating the 4p 2 P state. The collisions with ground state Na cause a very fast conversion of the 4p 2 P to the 3d 2 D state, from which the strongest emission is observed. (orig.)

  5. Suppression of Na interstitials in Na-F codoped ZnO

    Science.gov (United States)

    Huo, Wenxing; Mei, Zengxia; Tang, Aihua; Liang, Huili; Du, Xiaolong

    2018-04-01

    Controlling the formation of interstitial Na (Nai) self-compensating defects has been a long-term physics problem for effective Na doping in ZnO. Herein, we present an experimental approach to the suppression of Nai defects in ZnO via Na and F codoping under an oxygen-rich condition during the molecular beam epitaxy growth process. It is found that the incorporation of such large numbers of Na and F dopants (˜1020 cm-3) does not cause an obvious influence on the lattice parameters. Hall-effect measurements demonstrate that F doping efficiently raises the Fermi level (EF) of ZnO films, which is expected to make the formation energy of Nai and NaZn increase and decrease, respectively. Most of the Na atoms occupy the substitutional Zn sites, and the formation of Nai is suppressed consequently. Secondary ion mass spectrometry measurements reveal that F and Na atoms are tightly bonded together due to their strong Coulomb interaction. The enhanced deep level emission (DLE) in ZnO:Na-F is ascribed to the considerable amount of isolated Zn vacancy (VZn) defects induced by the elevated EF and the formation of neutral (" separators="| FO + - Na Zn - ) 0 complexes. On the other hand, formation of (" separators="| FO + - VZn 2 - ) - complexes in ZnO:F exhausts most of the isolated Zn vacancies, leading to the disappearance of the DLE band.

  6. Absolute quantification of Na + bound fraction by double-quantum filtered 23Na NMR spectroscopy

    Science.gov (United States)

    Mouaddab, Mohamed; Foucat, Loïc; Donnat, Jean Pierre; Renou, Jean Pierre; Bonny, Jean Marie

    2007-11-01

    A method is described for the absolute quantification of double-quantum filtered spectra of spin-3/2 nuclei ( 23Na). The method was tested on a model system, a cationic exchange resin for which the number of Na + binding sites was quantitatively controlled. The theoretical and experimental approaches were validated on samples with different Na + concentrations. An excellent agreement between the results obtained by double-quantum and single-quantum acquisitions was found. This method paves the way for absolute quantification of both bound and free fractions of Na +, which are determining factors in the characterization of salted/brined/dried food products.

  7. Interaction between Na+/K+-pump and Na+/Ca2+-exchanger modulates intercellular communication.

    Science.gov (United States)

    Matchkov, Vladimir V; Gustafsson, Helena; Rahman, Awahan; Briggs Boedtkjer, Donna M; Gorintin, Sarah; Hansen, Anne Kirstine; Bouzinova, Elena V; Praetorius, Helle A; Aalkjaer, Christian; Nilsson, Holger

    2007-04-13

    Ouabain, a specific inhibitor of the Na(+)/K(+)-pump, has previously been shown to interfere with intercellular communication. Here we test the hypothesis that the communication between vascular smooth muscle cells is regulated through an interaction between the Na(+)/K(+)-pump and the Na(+)/Ca(2+)-exchanger leading to an increase in the intracellular calcium concentration ([Ca(2+)](i)) in discrete areas near the plasma membrane. [Ca(2+)](i) in smooth muscle cells was imaged in cultured rat aortic smooth muscle cell pairs (A7r5) and in rat mesenteric small artery segments simultaneously with force. In A7r5 coupling between cells was estimated by measuring membrane capacitance. Smooth muscle cells were uncoupled when the Na(+)/K(+)-pump was inhibited either by a low concentration of ouabain, which also caused a localized increase of [Ca(2+)](i) near the membrane, or by ATP depletion. Reduction of Na(+)/K(+)-pump activity by removal of extracellular potassium ([K(+)](o)) also uncoupled cells, but only after inhibition of K(ATP) channels. Inhibition of the Na(+)/Ca(2+)-exchange activity by SEA0400 or by a reduction of the equilibrium potential (making it more negative) also uncoupled the cells. Depletion of intracellular Na(+) and clamping of [Ca(2+)](i) at low concentrations prevented the uncoupling. The experiments suggest that the Na(+)/K(+)-pump may affect gap junction conductivity via localized changes in [Ca(2+)](i) through modulation of Na(+)/Ca(2+)-exchanger activity.

  8. HCO3(-)-coupled Na+ influx is a major determinant of Na+ turnover and Na+/K+ pump activity in rat hepatocytes

    International Nuclear Information System (INIS)

    Fitz, J.G.; Lidofsky, S.D.; Weisiger, R.A.; Xie, M.H.; Cochran, M.; Grotmol, T.; Scharschmidt, B.F.

    1991-01-01

    Recent studies in hepatocytes indicate that Na(+)-coupled HCO3- transport contributes importantly to regulation of intracellular pH and membrane HCO3- transport. However, the direction of net coupled Na+ and HCO3- movement and the effect of HCO3- on Na+ turnover and Na+/K+ pump activity are not known. In these studies, the effect of HCO3- on Na+ influx and turnover were measured in primary rat hepatocyte cultures with 22Na+, and [Na+]i was measured in single hepatocytes using the Na(+)-sensitive fluorochrome SBFI. Na+/K+ pump activity was measured in intact perfused rat liver and hepatocyte monolayers as Na(+)-dependent or ouabain-suppressible 86Rb uptake, and was measured in single hepatocytes as the effect of transient pump inhibition by removal of extracellular K+ on membrane potential difference (PD) and [Na+]i. In hepatocyte monolayers, HCO3- increased 22Na+ entry and turnover rates by 50-65%, without measurably altering 22Na+ pool size or cell volume, and HCO3- also increased Na+/K+ pump activity by 70%. In single cells, exposure to HCO3- produced an abrupt and sustained rise in [Na+]i from approximately 8 to 12 mM. Na+/K+ pump activity assessed in single cells by PD excursions during transient K+ removal increased congruent to 2.5-fold in the presence of HCO3-, and the rise in [Na+]i produced by inhibition of the Na+/K+ pump was similarly increased congruent to 2.5-fold in the presence of HCO3-. In intact perfused rat liver, HCO3- increased both Na+/K+ pump activity and O2 consumption. These findings indicate that, in hepatocytes, net coupled Na+ and HCO3- movement is inward and represents a major determinant of Na+ influx and Na+/K+ pump activity. About half of hepatic Na+/K+ pump activity appears dedicated to recycling Na+ entering in conjunction with HCO3- to maintain [Na+]i within the physiologic range

  9. Clues to NaCN formation

    Science.gov (United States)

    Quintana-Lacaci, G.; Cernicharo, J.; Velilla Prieto, L.; Agúndez, M.; Castro-Carrizo, A.; Fonfría, J. P.; Massalkhi, S.; Pardo, J. R.

    2017-11-01

    Context. ALMA is providing us essential information on where certain molecules form. Observing where these molecules emission arises from, the physical conditions of the gas, and how this relates with the presence of other species allows us to understand the formation of many species, and to significantly improve our knowledge of the chemistry that occurs in the space. Aims: We studied the molecular distribution of NaCN around IRC +10216, a molecule detected previously, but whose origin is not clear. High angular resolution maps allow us to model the abundance distribution of this molecule and check suggested formation paths. Methods: We modeled the emission of NaCN assuming local thermal equilibrium (LTE) conditions. These profiles were fitted to azimuthal averaged intensity profiles to obtain an abundance distribution of NaCN. Results: We found that the presence of NaCN seems compatible with the presence of CN, probably as a result of the photodissociation of HCN, in the inner layers of the ejecta of IRC +10216. However, similar as for CH3CN, current photochemical models fail to reproduce this CN reservoir. We also found that the abundance peak of NaCN appears at a radius of 3 × 1015 cm, approximately where the abundance of NaCl, suggested to be the parent species, starts to decay. However, the abundance ratio shows that the NaCl abundance is lower than that obtained for NaCN. We expect that the LTE assumption might result in NaCN abundances higher than the real ones. Updated photochemical models, collisional rates, and reaction rates are essential to determine the possible paths of the NaCN formation. Based on observations carried out with ALMA and the IRAM 30 m Telescope. ALMA is a partnership of ESO (representing its member states), NSF (USA) and NINS (Japan), together with NRC (Canada) and NSC and ASIAA (Taiwan), in cooperation with the Republic of Chile. The Joint ALMA Observatory is operated by ESO, AUI/NRAO and NAOJ. IRAM is supported by INSU/CNRS (France

  10. Quasi–solid state rechargeable Na-CO2 batteries with reduced graphene oxide Na anodes

    Science.gov (United States)

    Hu, Xiaofei; Li, Zifan; Zhao, Yaran; Sun, Jianchao; Zhao, Qing; Wang, Jianbin; Tao, Zhanliang; Chen, Jun

    2017-01-01

    Na-CO2 batteries using earth-abundant Na and greenhouse gas CO2 are promising tools for mobile and stationary energy storage, but they still pose safety risks from leakage of liquid electrolyte and instability of the Na metal anode. These issues result in extremely harsh operating conditions of Na-CO2 batteries and increase the difficulty of scaling up this technology. We report the development of quasi–solid state Na-CO2 batteries with high safety using composite polymer electrolyte (CPE) and reduced graphene oxide (rGO) Na anodes. The CPE of PVDF-HFP [poly(vinylidene fluoride-co-hexafluoropropylene)]–4% SiO2/NaClO4–TEGDME (tetraethylene glycol dimethyl ether) has high ion conductivity (1.0 mS cm−1), robust toughness, a nonflammable matrix, and strong electrolyte-locking ability. In addition, the rGO-Na anode presents fast and nondendritic Na+ plating/stripping (5.7 to 16.5 mA cm−2). The improved kinetics and safety enable the constructed rGO-Na/CPE/CO2 batteries to successfully cycle in wide CO2 partial pressure window (5 to 100%, simulated car exhaust) and especially to run for 400 cycles at 500 mA g−1 with a fixed capacity of 1000 mA·hour g−1 in pure CO2. Furthermore, we scaled up the reversible capacity to 1.1 A·hour in pouch-type batteries (20 × 20 cm, 10 g, 232 Wh kg−1). This study makes quasi–solid state Na-CO2 batteries an attractive prospect. PMID:28164158

  11. Kupokelewa Zaidi Kwa Simu Ya Mkononi Kuliko Kompyuta Na ...

    African Journals Online (AJOL)

    Mtandao wa tovuti ni nyenzo ya msingi katika maendeleo ya uwanja wa mawasiliano unaounganisha watu na jamii mbalimbali katika ulimwengu wa leo unaotandawaa. Katika “ulimwengu wa kwanza na wa pili”, yaani mabara ya Amerika, Uropa na Asia, maendeleo na mapinduzi makubwa katika uwanja wa teknolojia ya ...

  12. Effects of different NaCl Concentrations on germination and ...

    African Journals Online (AJOL)

    Growth was steadily stimulated in both species at lower NaCl levels with best growth stimulation at 50 mM NaCl but was adversely affected by higher NaCl concentration levels (75, 100 and 150 mM). Both species ... Key words: Germination, early seedling growth, NaCl, salinity, Amaranthus hybridus, Celosia argentea.

  13. Ujanibishaji wa Office 2003 na Windows XP kwa Kiswahili Sanifu ...

    African Journals Online (AJOL)

    Mradi wa ujanibishaji wa Office 2003 na Windows XP kwa Kiswahili sanifu ulitekelezwa katika kipindi 2004-2005. Malengo ya mradi yalikuwa: (1) kuandaa istilahi za kompyuta kwa Kiingereza-Kiswahili, na (2) kutafsiri programu nne za kawaida za Office (Outlook, Excel, Word na PowerPoint) na Windows XP. Makala hii ina ...

  14. Mabadiliko Ya Kifonolojia Na Kimofolojia Wakati Wa Utohozi Wa ...

    African Journals Online (AJOL)

    Mwingiliano wa lugha ya Kiswahili na Kiarabu una historia ndefu kidogo. Inasemekana Waarabu walianza muwasala na 'Waswahili' tangu karne ya kwanza (BK) (Polome 1967:9). Kutokana na muwasala huo wa muda mrefu, lugha hizi mbili (Kiarabu na Kiswahili) zimeathiriana sana. Lakini kuna maoni kwamba Kiarabu ...

  15. Utata kuhusu Dhana na Chimbuko la Wahadimu katika Kisiwa cha ...

    African Journals Online (AJOL)

    Data za makala haya zimepatikana kupitia usaili na majadiliano ya majopo ya wazungumzaji wa Kimakunduchi na Unguja na kujadili kwa muhtasari chimbuko la Wahadimu. Kwa muda mrefu dhana ya Wahadimu imekuwa ikijadiliwa kwa mitazamo tofautitofauti kama inavyobainishwa na wataalamu mbalimbali wakiwemo ...

  16. O Passeio Público do Rio de Janeiro na Literatura, na Pintura e na Fotografia do Século XIX

    Directory of Open Access Journals (Sweden)

    Solange de Aragão

    2012-06-01

    Full Text Available Este artigo tem como objetivo geral e mais amplo chamar a atenção dos pesquisadores para a importância da literatura, da pintura e da fotografia como fontes documentais para a construção da História do Paisagismo no Brasil por meio de um estudo de caso muito particular: o Passeio Público do Rio de Janeiro no século XIX. São objetivos específicos apresentar e analisar o modo como esse espaço livre público aparece na literatura, na pintura e na fotografia desse período, considerando suas transformações paisagísticas.

  17. Muziki wa Hip Hop na Haki Za Kijamii: Dhima, Changamoto na ...

    African Journals Online (AJOL)

    Ni dhahiri kuwa haki za kijamii zinaweza kuwasilishwa kwa jamii pana kupitia sanaa ya hip hop. Makala haya basi, yanabainisha dhima na mchango wa muziki wa hip hop katika masuala ya haki za kijamii, yanafafanua changamoto za muziki huu katika kuwasilisha haki za kijamii na kutoa mapendekezo kwa makundi ...

  18. Regeneration of plantlets under NaCl stress from NaN3 treated ...

    African Journals Online (AJOL)

    In this experiment, mutation induction in explants using NaN3 and subsequently, callus growth and plant regeneration under NaCl stressed conditions was assessed in some sugarcane (Saccharum officinarum L.) cultivars (Thatta-10, CPF-237 and SPHS-19). Immature bases of leaf tips were cultured on MS2n (MS salts, 3.0 ...

  19. Molecular dynamics investigation of Na+ in Na2Ni2TeO6

    International Nuclear Information System (INIS)

    Sau, Kartik; Kumar, P. Padma

    2014-01-01

    An inter-atomic potential for Na 2 Ni 2 TeO 6 in the Parrinello- Rahman-Vashishta (PRV) model is parameterized empirically. The potential reproduces variety of structural and transport properties of that material in good agreement with recent experimental results. The study provides fresh insights on the migration channels and mechanism of Na + in the system

  20. NaI(Tl) electron energy resolution

    CERN Document Server

    Mengesha, W

    2002-01-01

    NaI(Tl) electron energy resolution eta sub e was measured using the Modified Compton Coincidence Technique (MCCT). The MCCT allowed detection of nearly monoenergetic internal electrons resulting from the scattering of incident 662 keV gamma rays within a primary NaI(Tl) detector. Scattered gamma rays were detected using a secondary HPGe detector in a coincidence mode. Measurements were carried out for electron energies ranging from 16 to 438 keV, by varying the scattering angle. Measured HPGe coincidence spectra were deconvolved to determine the scattered energy spectra from the NaI(Tl) detector. Subsequently, the NaI(Tl) electron energy spectra were determined by subtracting the energy of scattered spectra from the incident source energy (662 keV). Using chi-squared minimization, iterative deconvolution of the internal electron energy spectra from the measured NaI(Tl) spectra was then used to determine eta sub e at the electron energy of interest. eta sub e values determined using this technique represent va...

  1. Na/K pump inactivation, subsarcolemmal Na measurements, and cytoplasmic ion turnover kinetics contradict restricted Na spaces in murine cardiac myocytes.

    Science.gov (United States)

    Lu, Fang-Min; Hilgemann, Donald W

    2017-07-03

    Decades ago, it was proposed that Na transport in cardiac myocytes is modulated by large changes in cytoplasmic Na concentration within restricted subsarcolemmal spaces. Here, we probe this hypothesis for Na/K pumps by generating constitutive transsarcolemmal Na flux with the Na channel opener veratridine in whole-cell patch-clamp recordings. Using 25 mM Na in the patch pipette, pump currents decay strongly during continuous activation by extracellular K (τ, ∼2 s). In contradiction to depletion hypotheses, the decay becomes stronger when pump currents are decreased by hyperpolarization. Na channel currents are nearly unchanged by pump activity in these conditions, and conversely, continuous Na currents up to 0.5 nA in magnitude have negligible effects on pump currents. These outcomes are even more pronounced using 50 mM Li as a cytoplasmic Na congener. Thus, the Na/K pump current decay reflects mostly an inactivation mechanism that immobilizes Na/K pump charge movements, not cytoplasmic Na depletion. When channel currents are increased beyond 1 nA, models with unrestricted subsarcolemmal diffusion accurately predict current decay (τ ∼15 s) and reversal potential shifts observed for Na, Li, and K currents through Na channels opened by veratridine, as well as for Na, K, Cs, Li, and Cl currents recorded in nystatin-permeabilized myocytes. Ion concentrations in the pipette tip (i.e., access conductance) track without appreciable delay the current changes caused by sarcolemmal ion flux. Importantly, cytoplasmic mixing volumes, calculated from current decay kinetics, increase and decrease as expected with osmolarity changes (τ >30 s). Na/K pump current run-down over 20 min reflects a failure of pumps to recover from inactivation. Simulations reveal that pump inactivation coupled with Na-activated recovery enhances the rapidity and effectivity of Na homeostasis in cardiac myocytes. In conclusion, an autoregulatory mechanism enhances cardiac Na/K pump activity when

  2. Anion-coupled Na efflux mediated by the human red blood cell Na/K pump

    International Nuclear Information System (INIS)

    Dissing, S.; Hoffman, J.F.

    1990-01-01

    The red cell Na/K pump is known to continue to extrude Na when both Na and K are removed from the external medium. Because this ouabain-sensitive flux occurs in the absence of an exchangeable cation, it is referred to as uncoupled Na efflux. This flux is also known to be inhibited by 5 mM Nao but to a lesser extent than that inhibitable by ouabain. Uncoupled Na efflux via the Na/K pump therefore can be divided into a Nao-sensitive and Nao-insensitive component. We used DIDS-treated, SO4-equilibrated human red blood cells suspended in HEPES-buffered (pHo 7.4) MgSO4 or (Tris)2SO4, in which we measured 22Na efflux, 35SO4 efflux, and changes in the membrane potential with the fluorescent dye, diS-C3 (5). A principal finding is that uncoupled Na efflux occurs electroneurally, in contrast to the pump's normal electrogenic operation when exchanging Nai for Ko. This electroneutral uncoupled efflux of Na was found to be balanced by an efflux of cellular anions. (We were unable to detect any ouabain-sensitive uptake of protons, measured in an unbuffered medium at pH 7.4 with a Radiometer pH-STAT.) The Nao-sensitive efflux of Nai was found to be 1.95 +/- 0.10 times the Nao-sensitive efflux of (SO4)i, indicating that the stoichiometry of this cotransport is two Na+ per SO4=, accounting for 60-80% of the electroneutral Na efflux. The remainder portion, that is, the ouabain-sensitive Nao-insensitive component, has been identified as PO4-coupled Na transport and is the subject of a separate paper. That uncoupled Na efflux occurs as a cotransport with anions is supported by the result, obtained with resealed ghosts, that when internal and external SO4 was substituted by the impermeant anion, tartrate i,o, the efflux of Na was inhibited 60-80%. This inhibition could be relieved by the inclusion, before DIDS treatment, of 5 mM Cli,o

  3. Metallic Na formation in NaCl crystals with irradiation of electron or vacuum ultraviolet photon

    Energy Technology Data Exchange (ETDEWEB)

    Owaki, Shigehiro [Osaka Prefecture Univ., Sakai, Osaka (Japan). Coll. of Integrated Arts and Sciences; Koyama, Shigeko; Takahashi, Masao; Kamada, Masao; Suzuki, Ryouichi

    1997-03-01

    Metallic Na was formed in NaCl single crystals with irradiation of a variety of radiation sources and analyzed the physical states with several methods. In the case of irradiation of 21 MeV electron pulses to the crystal blocks, the optical absorption and lifetime measurement of positron annihilation indicated appearance of Na clusters inside. Radiation effects of electron beam of 30 keV to the crystals in vacuum showed the appearance of not only metallic Na but atomic one during irradiation with Auger electron spectroscopy. Intense photon fluxes in vacuum ultraviolet region of synchrotron radiation were used as another source and an analyzing method of ultraviolet photoelectron spectroscopy. The results showed the metallic Na layered so thick that bulk plasmon can exist. (author)

  4. Hydrolysis of Rice Straw Pretreated by Na2SO3 Over Fe-resin/NaCl

    Directory of Open Access Journals (Sweden)

    YANG Hui

    2017-05-01

    Full Text Available To increase the conversion of rice straw(RS and the yield of products, we employed three methods, which were ultrasonic wave, steam explosion and Na2SO3 pretreatment to pretreat RS(the treated RS noted as CS-RS, ZQ-RS and Na2SO3-RS, respectively and found that Na2SO3 treatment was the best pretreatment method based on XRD, SEM, elemental analysis and content of cellulose, hemicellulose and lignin. The conversion of Na2SO3-RS and the yield of total reducing sugar(TRS and levulinic acid(LA were 97.3%, 29.6% and 13.5%, respectively by 10% Fe-resin in 3.3% NaCl solution under 200 ℃.

  5. Muscle K+, Na+, and Cl- disturbances and Na+-K+ pump inactivation: implications for fatigue

    DEFF Research Database (Denmark)

    McKenna, Michael J; Bangsbo, Jens; Renaud, Jean-Marc

    2008-01-01

    (+)-ATPase activity during exercise stabilizes Na(+) and K(+) concentration gradients and membrane excitability and thus protects against fatigue. However, during intense contraction some Na(+)-K(+) pumps are inactivated and together with further ionic disturbances, likely precipitate muscle fatigue.......Membrane excitability is a critical regulatory step in skeletal muscle contraction and is modulated by local ionic concentrations, conductances, ion transporter activities, temperature, and humoral factors. Intense fatiguing contractions induce cellular K(+) efflux and Na(+) and Cl(-) influx......, causing pronounced perturbations in extracellular (interstitial) and intracellular K(+) and Na(+) concentrations. Muscle interstitial K(+) concentration may increase 1- to 2-fold to 11-13 mM and intracellular K(+) concentration fall by 1.3- to 1.7-fold; interstitial Na(+) concentration may decline by 10 m...

  6. Osmotic and ionic effects of NaCl and Na2SO4 salinity on Phragmites australis

    DEFF Research Database (Denmark)

    Pagter, Majken; Bragato, Claudia; Malagoli, Mario

    2009-01-01

    and partly Cl ions from the leaves. Incomplete exclusion of Cl from the leaves may affect aboveground biomass production, which was significantly more reduced by NaCl than Na2SO4. Stomatal conductance was negatively influenced by decreasing water potentials caused by NaCl or Na2SO4, implying that a non...

  7. Structure-function relationships of Na+, K+, ATP, or Mg2+ binding and energy transduction in Na,K-ATPase

    DEFF Research Database (Denmark)

    Jorgensen, Peter L.; Pedersen, Per Amstrup

    2000-01-01

    Na,K-ATPase; Mutagenesis; Na+ binding; K+ binding; Tl+ binding; Mg2+ binding; ATP binding; Cation binding site; Energy transduction......Na,K-ATPase; Mutagenesis; Na+ binding; K+ binding; Tl+ binding; Mg2+ binding; ATP binding; Cation binding site; Energy transduction...

  8. Long-Range Effects of Na(+) Binding in Na,K-ATPase Reported by ATP.

    Science.gov (United States)

    Middleton, David A; Fedosova, Natalya U; Esmann, Mikael

    2015-12-01

    This paper addresses the question of long-range interactions between the intramembranous cation binding sites and the cytoplasmic nucleotide binding site of the ubiquitous ion-transporting Na,K-ATPase using (13)C cross-polarization magic-angle spinning (CP-MAS) solid-state nuclear magnetic resonance. High-affinity ATP binding is induced by the presence of Na(+) as well as of Na-like substances such as Tris(+), and these ions are equally efficient promoters of nucleotide binding. CP-MAS analysis of bound ATP with Na,K-ATPase purified from pig kidney membranes reveals subtle differences in the nucleotide interactions within the nucleotide site depending on whether Na(+) or Tris(+) is used to induce binding. Differences in chemical shifts for ATP atoms C1' and C5' observed in the presence of Na(+) or Tris(+) suggest alterations in the residues surrounding the bound nucleotide, hydrogen bonding, and/or conformation of the ribose ring. This is taken as evidence of a long-distance communication between the Na(+)-filled ion sites in the membrane interior and the nucleotide binding site in the cytoplasmic domain and reflects the first conformational change ultimately leading to phosphorylation of the enzyme. Stopped-flow fluorescence measurements with the nucleotide analogue eosin show that the dissociation rate constant for eosin is larger in Tris(+) than in Na(+), giving kinetic evidence of the difference in structural effects of Na(+) and Tris(+). According to the recent crystal structure of the E1·AlF4(-)·ADP·3Na(+) form, the coupling between the ion binding sites and the nucleotide side is mediated by, among others, the M5 helix.

  9. Eletrencefalograma na síndrome parkinsoniana

    Directory of Open Access Journals (Sweden)

    José Geraldo Camargo Lima

    1973-09-01

    Full Text Available Foram estudados os eletrencefalogramas de 50 pacientes parkinsonianos livres de qualquer antecedente convulsivo, sendo registrados traçados anormais em 40% dos casos. A incidência de traçados anormais foi maior na síndrome parkinsoniana bilateral do que na unilateral (52% e 25%, respectivamente. Entre as anormalidades assinaladas foram as paroxísticas as mais freqüentes (65% dos casos, caracterizando-se predominantemente por surtos de ondas teta. O registro de anormalidades paroxísticas do tipo irritativo encontrado em três casos é salientado. Alterações da atividade de base foram assinaladas em 35% dos pacientes. A idade dos pacientes não parece ter tido importante papel na gênese das anormalidades eletrencefalográficas.

  10. Knjige o kartografskim projekcijama na internetu

    Directory of Open Access Journals (Sweden)

    Nedjeljko Frančula

    2011-12-01

    Full Text Available U ovom prikazu skrećemo pozornost na neke knjige o kartografskim projekcijama koje su prvobitno objavljene u tisku, a potom digitalizirane i besplatno stavljene na mrežu. Neke od tih knjiga nude se na mreži kao Google e-knjige. Google godinama skuplja knjige kojima su istekla autorska prava i digitalizira ih. Fotografira se svaka stranica te zatim spaja u jednu veliku fotografiju iz koje se izvlači tekst softverom OCR. Google čuva originalnu digitalnu fotografiju u svom arhivu, a izvučeni tekst pretvara u formate HTML, PDF ili EPUB. Google danas nudi više od milijun besplatnih e-knjiga (http://www.google.com/books.

  11. Tecnologia simplificada na enfermagem materno infantil

    Directory of Open Access Journals (Sweden)

    Selma Campestrini

    1991-09-01

    Full Text Available A autora apresenta três modelos de tecnologia simplificada da enfermagem materno infantil: o equipamento didático SEIO COBAIA para treinar exercícios e massagens da mama e mamilo; a peça indumentária SUPRETRAUMA - sutiã preventivo de traumatismo mamilar - usado por gestantes; e, a técnica para reverter mamilo umbilicado durante o puerperio imediato. Além de corroborar na promoção do aleitamento materno e na prevenção de desmame precoce, demonstra a possibilidade da enfermagem relacionar o saber teórico-científico com o saber tecnico-prático, na saúde da mulher e da criança, com tecnologia adequada às necessidades, à compreensão e ao bem estar da população.

  12. Hidroginástica na terceira idade

    OpenAIRE

    Paula, Karla Campos de; Paula, Débora Campos de

    1998-01-01

    O processo de envelhecimento no indivíduo saudável está relacionado com inúmeras alterações psicológicas e físicas que interferem na área motora, concorrendo para a inatividade e contribuindo para o aparecimento e agravamento de determinadas doenças, além de influenciar negativamente a realização das atividades de vida diária. Portanto, a prática de atividade física é fundamental para o idoso, não só na prevenção de doenças como na reabilitação de suas habilidades motoras, promovendo um estil...

  13. Labirintos na cidade contemporânea

    Directory of Open Access Journals (Sweden)

    Edson Luiz André de Sousa

    Full Text Available Este artigo pretende tensionar pontos de conexão e diluição de fronteiras entre as categorias público/privado, conversando com a literatura de Baudelaire e W. Benjamin, Fredric Jamenson e Marc Augé. Através da imagem do labirinto, símbolo da cidade antiga que se quis extinguir na cidade moderna, busca-se refletir sobre alguns caminhos e caminhantes considerados excedentes na cidade contemporânea. O cenário propulsor dessa reflexão é a experiência do jornal Boca de Rua, elaborado por moradores de rua na cidade de Porto Alegre.

  14. Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state.

    Science.gov (United States)

    Kanai, Ryuta; Ogawa, Haruo; Vilsen, Bente; Cornelius, Flemming; Toyoshima, Chikashi

    2013-10-10

    Na(+),K(+)-ATPase pumps three Na(+) ions out of cells in exchange for two K(+) taken up from the extracellular medium per ATP molecule hydrolysed, thereby establishing Na(+) and K(+) gradients across the membrane in all animal cells. These ion gradients are used in many fundamental processes, notably excitation of nerve cells. Here we describe 2.8 Å-resolution crystal structures of this ATPase from pig kidney with bound Na(+), ADP and aluminium fluoride, a stable phosphate analogue, with and without oligomycin that promotes Na(+) occlusion. These crystal structures represent a transition state preceding the phosphorylated intermediate (E1P) in which three Na(+) ions are occluded. Details of the Na(+)-binding sites show how this ATPase functions as a Na(+)-specific pump, rejecting K(+) and Ca(2+), even though its affinity for Na(+) is low (millimolar dissociation constant). A mechanism for sequential, cooperative Na(+) binding can now be formulated in atomic detail.

  15. A perda de chance na responsabilidade civil

    OpenAIRE

    Silva, Rute Eunice Andrade Teixeira da

    2017-01-01

    Resumo: O presente trabalho tem como objecto de estudo a teoria da perda de chance. Tema ainda controverso tanto na doutrina como na jurisprudência, urge fazer-se uma análise do mesmo no âmbito do direito português. Para um melhor entendimento sobre a figura da perda de chance, é necessário ter presente alguns aspectos do instituto da responsabilidade civil. Será realizada uma análise geral dos pressupostos da responsabilidade civil, versando-nos principalmente sobre o dano e o ne...

  16. O trabalho na África subsariana

    OpenAIRE

    Carneiro, Emmanuel Moreira

    2008-01-01

    A natureza do trabalho e do mercado de emprego na África subsariana está intrinsecamente ligado ao tipo de produção material dominante, à natureza das relações de produção estabelecidas, bem como ao inerente sistema de formação e distribuição do rendimento. É ainda profundamente condicionada pela evolução do processo de estruturação mundial do capitalismo, o qual se traduz, na fase actual, pelo que se convencionou designar mundialização e globalização.

  17. A TEOLOGIA LATINO-AMERICANA NA ENCRUZILHADA

    Directory of Open Access Journals (Sweden)

    Victor Codina

    1999-01-01

    Full Text Available As mudanças ocorridas no mundo, no fim dos anos 80, não podem deixar de afetar a Teologia latino-americana e, muito concretamente, a Teologia da Libertação (TdL, teologia que nasceu na América Latina na década de 701. A TdL encontra-se hoje numa encruzilhada: retroceder e dar marcha a ré? Continuar repetindo o que até agora foi dito, como se nada tivesse acontecido?

  18. A Imagem como Ruína

    Directory of Open Access Journals (Sweden)

    Míriam Volpe

    2001-12-01

    Full Text Available O dialogismo ente o filme Citizen Kane, de Orson Welles, e o poema “Kubla Khan”, de S.T. Coleridgé, é analisado, sendo evidenciados não só o tema em comum – o mito do Paraíso perdido – como também a similariedade na organização do disurso na justaposição das images, como fragmentos da memória a serem preservados.

  19. Sexualidade na velhice e qualidade de vida

    OpenAIRE

    Viana, Helena Brandão; Madruga, Vera Aparecida

    2010-01-01

    O objetivo deste trabalho, realizado por meio de uma revisão de literatura, foi abordar uma revisão literária sobre a influência da sexualidade na qualidade de vida deidosos, temática pouco discutida nas diferentes áreas de pesquisas sobre envelhecimento. Diante da escassez de bibliografia na cultura brasileira, apresentou-se uma revisão de literatura sobre envelhecimento junto à temática da sexualidade, trazendo uma trajetória histórica sobre estudos de sexualidade ao longo do tempo, discuti...

  20. E-GRADIVA NA PRIMERU OBRAVNAVE GLAGOLA

    OpenAIRE

    Kajtna, Tjaša

    2013-01-01

    Sodobne tehnologije so korenito spremenile današnji način življenja. Tako je tudi z izobraževanjem. Vedno več učiteljev ob klasičnih metodah poučevanja uporablja tudi nove pristope, ki so povezani s sodobnimi tehnologijami. V diplomskem delu je opredeljeno e-izobraževanje, predstavljene so nove tehnologije, ki se pojavljajo v povezavi z le-tem. V nadaljevanju sledi teoretična obravnava e-gradiv, ki ob podpori informacijsko komunikacijskih tehnologij predstavljajo temelj e-izobraževanja. ...

  1. ANALIZA IZGUB NA OSLABLJENEM PRENAPETOSTNEM ODVODNIKU

    OpenAIRE

    Ajdnik, Miran

    2011-01-01

    Diplomska naloga obravnava problematiko izgub električne energije na oslabljenem prenapetostnem odvodniku na transformatorski postaji Kot-Makej (0,95/0,4 kV) in neozemljenem izvoru. Omenjena transformatorska postaja se napaja iz razdelilne transformatorske postaje Ravne (RTP RAVNE) preko 20 kV daljnovoda Mežica in transformatorske postaje Kot (20/0,95/0,4 kV). Rešitev je predstavljena s programskim orodjem MATLAB/Simulink iz knjižnice PowerSystem, s katerim je izvedena simulacija pri oslablje...

  2. Vpliv tripsinizacije na celice Caco-2.

    OpenAIRE

    Cuculić, Nika

    2018-01-01

    Caco-2 celična linija se uporablja v številnih predkliničnih raziskavah. Ena izmed najbolj izraženih lastnosti celične linije Caco-2 je njihova zmožnost spontane diferenciacije. Zaradi različnega rokovanja s celično linijo Caco-2 med laboratoriji, v kar spada tudi uporaba različnih koncentracij tripsina ter čas izpostavljenosti celic tripsinu, se rezultati raziskav med laboratoriji lahko zelo razlikujejo in niso primerljivi. Preverili smo vpliv različnih koncentracij tripsina na celično viabi...

  3. Izbor i prilagodba nadogradnje na implantatima

    OpenAIRE

    Belamarić, Sara

    2017-01-01

    Implantatne nadogradnje su spojni elementi između tijela implantata, kirurški postavljenog u kost, koji predstavlja zamjenu za prirodni korijen zuba i protetske suprastrukture kojom se nadoknađuje oblik, boja i funkcija zuba koji nedostaje. One predstavljaju središte funkcijskih i estetskih aspekata implantološke terapije. Imaju direktan utjecaj na dugoročnu prognozu i uspjeh ovog terapijskog postupka. Danas na tržištu postoji čitav niz dostupnih implantatnih nadogradnji. Najčešći materijali ...

  4. Recent results and prospects from NA62

    Directory of Open Access Journals (Sweden)

    Bizzeti Andrea

    2016-01-01

    K+ → π+ vv̄ is a theoretically very clean decay where indirect effects of new physics may be detectable. The NA62 apparatus has been significantly upgraded between 2008 and 2014 in order to measure the branching ratio of this decay with 10% precision. The NA62 experiment took data with the new setup in pilot runs in 2014 and 2015, reaching the design beam intensity. Results of first data quality studies in view of the 2016-2017 physics runs are presented.

  5. MEDGENERACIJSKI PRENOS ZNANJA NA DELOVNEM MESTU

    OpenAIRE

    Movern, Tina

    2015-01-01

    Prenos znanja med ljudmi igra ključno vlogo pri razvoju ter napredku človeštva. Nekaterih najbolj kompleksnih znanj kot so jeziki in kulturne norme, so lahko naučena oziroma priučena od drugih ljudi, ti pa so jih pridobili od prejšnjih generacij. Kot glavno gonilno silo razvoja neke organizacije bi prav lahko vzeli količino, kvaliteto in možnost upravljanja prenosa znanj v sami organizaciji, kar je tudi glavni predmet naše raziskave. Diplomska naloga je razdeljena na teoretični in empiri...

  6. Osteossarcoma parosteal: aspectos na radiologia convencional

    OpenAIRE

    Nanci Neto,Francisco; Marchiori,Edson; Vianna,Alberto Domingues; Aymoré,Ierecê Lins; Almeida,Ana Luiza Brito de; Irion,Klaus L.; Collares,Felipe Birchal

    2007-01-01

    OBJETIVO: Avaliar os achados clínicos mais importantes do osteossarcoma parosteal e descrever os seus aspectos mais comuns na radiologia convencional. MATERIAIS E MÉTODOS: Estudo retrospectivo com 26 pacientes com osteossarcoma parosteal, provenientes do arquivo do Clube do Osso, Rio de Janeiro, RJ, e análise dos principais achados clínicos e aspectos radiológicos. RESULTADOS: A doença predominou em pacientes do sexo feminino e teve idade média de acometimento na terceira década de vida. Os a...

  7. O problema do conhecimento verdadeiro na epidemiologia

    Directory of Open Access Journals (Sweden)

    Ayres José Ricardo de Carvalho Mesquita

    1992-01-01

    Full Text Available São examinadas as bases filosóficas da validação do conhecimento científico, com o intuito de estabelecer uma visão crítica a respeito da adoção das proposições de Popper na epidemiologia. Ressalta-se o caráter conservador que resulta das limitações técnicas implicadas na sua adoção, não obstante o evidente aumento da racionalidade e da criatividade heurística que propicia.

  8. Na+/K+-ATPase: Activity and inhibition

    Science.gov (United States)

    Čolović, M.; Krstić, D.; Krinulović, K.; Momić, T.; Savić, J.; Vujačić, A.; Vasić, V.

    2009-09-01

    The aim of the study was to give an overview of the mechanism of inhibition of Na+/K+-ATPase activity induced by some specific and non specific inhibitors. For this purpose, the effects of some ouabain like compounds (digoxin, gitoxin), noble metals complexes ([PtCl2DMSO2], [AuCl4]-, [PdCl4]2-, [PdCl(dien)]+, [PdCl(Me4dien)]+), transition metal ions (Cu2+, Zn2+, Fe2+, Co2+), and heavy metal ions (Hg2+, Pb2+, Cd2+) on the activity of Na+/K+-ATPase from rat synaptic plasma membranes (SPM), porcine cerebral cortex and human erythrocytes were discussed.

  9. Na, K-ATPase as signaling transducer

    OpenAIRE

    Li, Juan

    2007-01-01

    It is now generally agreed that Na,K-ATPase (NKA), in addition to its role in the maintenance of Na+ and K+ gradients across the cell membrane, is a signal transducer. Our group has identified a novel signaling pathway where NKA interact with IP3R to form a signaling microdomain. Ouabain, a specific ligand of NKA, activates this pathway, triggers slow Ca2+ oscillations and activates NF-κB. In current study, the molecular mechanisms and some important downstream effects of NK...

  10. Europlanet-2020 NA1 Exchange Program

    Science.gov (United States)

    Genzer, M.; Szego, K.; Haukka, H.; Harri, A.-M.

    2017-09-01

    The task of Exchange Program of NA1 is to support the activities of EPN2020 with experts and scientific exchange whenever it is needed. Short visits (up to 1 week) with the goal of improving infrastructure facilities and services offered to the scientific community are supported from this task. Since the start of the EPN2020 in September 2015 we have received and approved 14 applications for exchange program travel. More general and specifically targeted calls are planned for the future. The calls are announced on Europlanet-2020 NA1 web site.

  11. Abordagem neurologica na sindrome do X fragil

    OpenAIRE

    Marilisa Mantovani Guerreiro

    1993-01-01

    Resumo: Com o propósito de realizar a abordagem neurológica na Síndrome do X Frágil (SXF), estudaram-se 11 pacientes com este diagnóstico citogenético. A idade variou de 8 a 19 anos. Nove pacientes eram do sexo masculino e dois do feminino. Todos os indivíduos apresentaram pavilhões auriculares grandes e faces alongadas. Observou-se fronte proeminente em 63% dos casos e macrorquidia em 33% dentre aqueles do sexo masculino. Atraso na aquisição da fala, fala repetitiva, perseverativa, impulsiva...

  12. MANAGEMENT DOGODKOV NA PRIMERU NIKE KONVENCIJE

    OpenAIRE

    Kapić, Sara

    2010-01-01

    V diplomski nalogi je predstavljen potek ustvarjanja in izvedbe dogodka, ki zajema številne aktivnosti, in sicer na primeru Nike konvencije. Namen diplomske naloge je namreč podati kritično oceno izvajanja aktivnosti, z namenom ugotoviti, katere aktivnosti bi se v okviru upravljanja z dogodkom lahko izpeljale boljše in podati predloge za uspešnejšo zasnovo in organizacijo naslednje Nike konvencije. Na podlagi posnetka je ugotovljeno, da je pri organizaciji, vodenju, izvedbi in nadzoru prihaja...

  13. Alterações cognitivas na esquizofrenia

    OpenAIRE

    THEIL, Ruth Bonow

    2003-01-01

    Este estudo é uma revisão da literatura sobre o comprometimento cognitivo na esquizofrenia. Objetivou-se a análise da natureza e do padrão desse comprometimento, o estabelecimento de associações entre as variáveis clínicas e o desempenho neuropsicológico, e a determinação das correlações entre os déficits cognitivos na esquizofrenia e seus substratos neurais subjacentes. Foram inicialmente revistos os conceitos de esquizofrenia e sua evolução histórica, aspectos clínicos, cl...

  14. IDENTIDADE E CORPO NA MARCHA DAS VADIAS

    OpenAIRE

    Ribeiro Quintanilha de Souza, Aline

    2015-01-01

    O objetivo deste trabalho é analisar os temas de identidade de gênero e corporalidade na Marcha das Vadias. Esta é um movimento social que tem recebido visibilidade e experimentado um grande crescimento em adeptos e importância para as questões de gênero no Brasil. Este trabalho busca entender como práticas corporais são construídas para um objetivo político específico. Pretendo relacionar as principais reivindicações políticas desenvolvidas na manifestação com a construção da identidade "vad...

  15. Glutathionylation-Dependence of Na(+)-K(+)-Pump Currents Can Mimic Reduced Subsarcolemmal Na(+) Diffusion.

    Science.gov (United States)

    Garcia, Alvaro; Liu, Chia-Chi; Cornelius, Flemming; Clarke, Ronald J; Rasmussen, Helge H

    2016-03-08

    The existence of a subsarcolemmal space with restricted diffusion for Na(+) in cardiac myocytes has been inferred from a transient peak electrogenic Na(+)-K(+) pump current beyond steady state on reexposure of myocytes to K(+) after a period of exposure to K(+)-free extracellular solution. The transient peak current is attributed to enhanced electrogenic pumping of Na(+) that accumulated in the diffusion-restricted space during pump inhibition in K(+)-free extracellular solution. However, there are no known physical barriers that account for such restricted Na(+) diffusion, and we examined if changes of activity of the Na(+)-K(+) pump itself cause the transient peak current. Reexposure to K(+) reproduced a transient current beyond steady state in voltage-clamped ventricular myocytes as reported by others. Persistence of it when the Na(+) concentration in patch pipette solutions perfusing the intracellular compartment was high and elimination of it with K(+)-free pipette solution could not be reconciled with restricted subsarcolemmal Na(+) diffusion. The pattern of the transient current early after pump activation was dependent on transmembrane Na(+)- and K(+) concentration gradients suggesting the currents were related to the conformational poise imposed on the pump. We examined if the currents might be accounted for by changes in glutathionylation of the β1 Na(+)-K(+) pump subunit, a reversible oxidative modification that inhibits the pump. Susceptibility of the β1 subunit to glutathionylation depends on the conformational poise of the Na(+)-K(+) pump, and glutathionylation with the pump stabilized in conformations equivalent to those expected to be imposed on voltage-clamped myocytes supported this hypothesis. So did elimination of the transient K(+)-induced peak Na(+)-K(+) pump current when we included glutaredoxin 1 in patch pipette solutions to reverse glutathionylation. We conclude that transient K(+)-induced peak Na(+)-K(+) pump current reflects the effect

  16. In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition

    DEFF Research Database (Denmark)

    Zhang, Y; Norian, J M; Magyar, C E

    1999-01-01

    The aim of this study was to test the hypothesis that in vivo administration of parathyroid hormone (PTH) provokes diuresis/natriuresis through redistribution of proximal tubule apical sodium cotransporters (NHE3 and NaPi2) to internal stores and inhibition of basolateral Na-K-ATPase activity....../diuresis and NHE3 and NaPi2 internalization, and that Na-K-ATPase inhibition is not secondary to depressed apical Na+ transport....

  17. Water transport by the renal Na(+)-dicarboxylate cotransporter

    DEFF Research Database (Denmark)

    Meinild, A K; Loo, D D; Pajor, A M

    2000-01-01

    This study investigated the ability of the renal Na(+)-dicarboxylate cotransporter, NaDC-1, to transport water. Rabbit NaDC-1 was expressed in Xenopus laevis oocytes, cotransporter activity was measured as the inward current generated by substrate (citrate or succinate), and water transport...... was monitored by the changes in oocyte volume. In the absence of substrates, oocytes expressing NaDC-1 showed an increase in osmotic water permeability, which was directly correlated with the expression level of NaDC-1. When NaDC-1 was transporting substrates, there was a concomitant increase in oocyte volume....... This solute-coupled influx of water took place in the absence of, and even against, osmotic gradients. There was a strict stoichiometric relationship between Na(+), substrate, and water transport of 3 Na(+), 1 dicarboxylate, and 176 water molecules/transport cycle. These results indicate that the renal Na...

  18. Intracellular Na(+) and metabolic modulation of Na/K pump and excitability in the rat suprachiasmatic nucleus neurons.

    Science.gov (United States)

    Wang, Yi-Chi; Yang, Jyh-Jeen; Huang, Rong-Chi

    2012-10-01

    Na/K pump activity and metabolic rate are both higher during the day in the suprachiasmatic nucleus (SCN) that houses the circadian clock. Here we investigated the role of intracellular Na(+) and energy metabolism in regulating Na/K pump activity and neuronal excitability. Removal of extracellular K(+) to block the Na/K pump excited SCN neurons to fire at higher rates and return to normal K(+) to reactivate the pump produced rebound hyperpolarization to inhibit firing. In the presence of tetrodotoxin to block the action potentials, both zero K(+)-induced depolarization and rebound hyperpolarization were blocked by the cardiac glycoside strophanthidin. Ratiometric Na(+) imaging with a Na(+)-sensitive fluorescent dye indicated saturating accumulation of intracellular Na(+) in response to pump blockade with zero K(+). The Na(+) ionophore monensin also induced Na(+) loading and hyperpolarized the membrane potential, with the hyperpolarizing effect of monensin abolished in zero Na(+) or by pump blockade. Conversely, Na(+) depletion with Na(+)-free pipette solution depolarized membrane potential but retained residual Na/K pump activity. Cyanide inhibition of oxidative phosphorylation blocked the Na/K pump to depolarize resting potential and increase spontaneous firing in most cells, and to raise intracellular Na(+) levels in all cells. Nonetheless, the Na/K pump was incompletely blocked by cyanide but completely blocked by iodoacetate to inhibit glycolysis, indicating the involvement of both oxidative phosphorylation and glycolysis in fueling the Na/K pump. Together, the results indicate the importance of intracellular Na(+) and energy metabolism in regulating Na/K pump activity as well as neuronal excitability in the SCN neurons.

  19. Presoja notranjih kontrol pri obračunu davka na dodano vrednost na primeru "Podjetja x"

    OpenAIRE

    Majcen, Borut

    2016-01-01

    Poslovanje podjetja si je ob odsotnosti notranjih kontrol nemogoče predstavljati. Podjetja so podvržena raznim tveganjem, še posebej v današnjih razmerah globalnega poslovanja, ko se podjetja soočajo z vedno novimi izzivi, kar prinaša tudi nova tveganja. Najučinkovitejši ukrep za obvladovanje tveganj predstavlja vzpostavitev sistema notranjih kontrol. Obvladovanje tveganj pa ne poteka samo na ravni podjetja kot celote, ampak je prisotno na vseh področjih delovanja podjetja, torej tudi na p...

  20. (1) Na-Allah et al

    African Journals Online (AJOL)

    Adeyinka Odunsi

    Na-Allah, Y., Zamnao, A. *Garba, S. and Abdullahi, A. U.. Department of Animal Science, Faculty of Agriculture,. Usmanu Danfodiyo University, P. M. B. 2346, Sokoto-Nigeria. *Corresponding author: email; sanigarba2003@yahoo.com Phone no. +234(0)8067090255. Abstract. This study evaluated the pre-‐weaning growth ...

  1. Habitus professoral na sala de aula virtual

    Directory of Open Access Journals (Sweden)

    Alexandre Marinho Pimenta

    2014-09-01

    Full Text Available Entendendo que a indiferença na ação pedagógica contribui para a reprodução das desigualdades no sistema de ensino, o presente artigo busca captar, a partir de entrevistas semiestruturadas, traços do habitus de professores supervisores de disciplinas do curso de Licenciatura em Pedagogia na modalidade a distância na Universidade de Brasília - UnB no âmbito do Sistema Universidade Aberta do Brasil - UAB. As orientações metodológicas de Bourdieu (2007 foram um dos elementos orientadores na análise das entrevistas, considerando ainda o uso heurístico do conceito de habitus. Conclui-se que o habitus professoral envolve esforços voluntários em busca de uma ação pedagógica diferenciada. No entanto, ele é ambíguo e condescendente frente aos limites do modelo de EaD no âmbito da UAB. Ao fim, os dados analisados permitem fornecer elementos para reorientação político-pedagógica que vise a um novo modelo de EaD nacional.

  2. Le Hodler d'Iéna

    OpenAIRE

    2017-01-01

    Suites de la protestation contre le bombardement de la cathédrale de Reims. Nouvelle proposition de M. Gunsburger pour le rachat du tableau de Hodler "Départ des étudiants d'Iéna pour la guerre de libération contre Napoléon en 1813".

  3. Study of deconfinement in NA50

    Indian Academy of Sciences (India)

    Corrado Cicalo

    from the forward hadronic energy measured in the very forward hadronic calorimeter. 2. Experimental setup and data selection. The NA50 apparatus [6] mainly consists of a muon spectrometer, a segmented active target and three independent centrality detectors: an electromagnetic calorimeter which measures the neutral ...

  4. Pijn tijdens of na de wortelkanaalbehandeling

    NARCIS (Netherlands)

    Wesselink, P.R.

    2012-01-01

    Een wortelkanaalbehandeling kan pijn veroorzaken tijdens en/of na de behandeling. Tijdens de behandeling moet dan onderscheid worden gemaakt tussen pijn bij een pulpitis en pijn bij een necrotische pulpa. In beide gevallen kan die pijn effectief worden bestreden, afhankelijk van de toestand waarin

  5. Leitura na escola: um barco à deriva?

    Directory of Open Access Journals (Sweden)

    Teixeira, Marlene

    2008-01-01

    Full Text Available Este artigo busca, na teoria da enunciação de É. Benveniste, elementos para repensar o trabalho com a leitura na escola. Considera que, na discussão das noções gêmeas de forma e sentido, o autor formula uma concepção de significado que, de um lado, pode deter a interpretação à deriva, implicada na visão de leitura centrada no leitor, e, de outro lado, possibilita que se transcenda a idéia de que é pela decifração mdo código que se dá o processo de construção do significado. Conclui que, no processo de leitura, é sempre de um trabalho com a língua que se trata, trabalho que se renova a cada ato de aproximação do aluno com o texto, porque a língua é submetida ao ato de enunciação

  6. NA49: lead-lead collision

    CERN Multimedia

    1996-01-01

    This is an image of an actual lead ion collision taken from tracking detectors on the NA49 experiment, part of the heavy ion project at CERN. These collisions produce a very complicated array of hadrons as the heavy ions break up. It is hoped that one of these collisions will eventually create a new state of matter known as quark-gluon plasma.

  7. Nucleotide binding to Na+/K+-ATPase

    Czech Academy of Sciences Publication Activity Database

    Kubala, Martin; Lánský, Zdeněk; Ettrich, R.; Plášek, J.; Teisinger, Jan; Amler, Evžen

    2005-01-01

    Roč. 272, č. S1 (2005), s. 191-191 E-ISSN 1742-4658. [FEBS Congress /30./ and IUBMB Conference /9./. 02.07.2005-07.07.2005, Budapest] Keywords : Na+/K+- ATPase * ATP binding * TNP-ATP Subject RIV: BO - Biophysics

  8. Therapy of hyperthyroidism with Na131I

    International Nuclear Information System (INIS)

    Kakehi, Hirotake; Furukawa, Takashi; Fukakusa, Shunichi; Futonaka, Hiroshi; Takahashi, Yuji

    1984-01-01

    Forty one patients of hyperthyroidism were treated with Na 131 I. Men and women are in the ratio 1:3.1. The ages of patients are between twenties and sixties and the forties are the highest in number. The observation period of clinical courses is between 1 and 8 years. The number of patients observed over 5 years are 51% of them and over 2 years are 83%. The treatment frequency is as follows: On 37 cases each one was treated once with Na 131 I. 2 cases twice, 1 case at 4 times in 3 years and 1 case at 5 times in 6 years. The treatment doses are between 4,000-6,000 rad (40-60 Gray). In the cases treated with the irradiation dose of 6,000 rad, we often saw hypothyroidism. In cases aiming 4,000-5,000 rad, there is a tendency of leaving hyperthyroidism unrecovered. In conclusion, the patients should be treated giving 4,000-5,000 rad or with Na 131 I doses of 3-6mCi. If the effects of the treatment are insufficient, the patients should be further treated with anti-thyroid drug or treated again with Na 131 I. As the result, there are at present 25 cases (61.0%) in normal status of the thyroid gland, 12 cases (29.2%) in hyperthyroidism and 4 cases (9.8%) in hypothyroidism totaling 41 cases in all. (author)

  9. NA48: Wiring up for Change

    CERN Multimedia

    2001-01-01

    The NA48 Collaboration is rebuilding its drift chambers ready for the experiment to start up again this coming July. An intricate task involving the soldering of over 24,000 wires! The future of the NA48 experiment is coming right down to the wire, that is, the wires which the Collaboration is installing in the clean room of Hall 887 on the Prévessin site. Six days a week, technicians are working in shifts to rebuild the experiment's drift chambers. The original chambers were damaged when a section of a vacuum tube imploded at the end of 1999. A year ago, CERN gave the green light for this essential part of the spectrometer to be rebuilt, so the NA48 experiment, which studies CP violation (see box), still has a bright future ahead of it. Three years of data-taking ahead The NA48 experiment aims to penetrate the secrets of CP (Charge Parity) violation. Charge and parity are two parameters which distinguish a particle from an antiparticle. In other words, an electron possesses a negative electric ...

  10. Study of deconfinement in NA50

    Indian Academy of Sciences (India)

    Corrado Cicalo

    The anomalous J/ψ pattern suppression observed in NA50 experiment is a clear evidence of the transition to a deconfined state of matter. Acknowledgements. This work was partially supported by Fundaç˜ao para a Ciência e a Tecnologia, by INTAS grant 96-0231 and by the Russian Foundation for Fundamental Research, ...

  11. Zasvojenost z igrami na srečo : magistrsko delo

    OpenAIRE

    Rozman, Patricia

    2014-01-01

    Namen magistrske naloge je predstaviti eno izmed najbolj skritih oblik zasvojenosti, to je zasvojenost z igrami na srečo. Zanimalo me je, kako ta oblika zasvojenosti vpliva na posameznika, tako telesno kot duševno. Ali posameznikova zasvojenost vpliva na ljudi okoli njega, na njegovo družino, prijatelje, znance in službo, ter kako se zasvojenec s tem sooča. Predvsem me je zanimalo, ali zasvojenost z igrami na srečo vodi v kriminalna dejanja in kakšna so ta dejanja ter kako je to ureje...

  12. VPLIV BARVE EMBALAŽE NA ZAZNAVANJE OKUSA GOSTEGA SOKA

    OpenAIRE

    Prevolšek, Daša

    2016-01-01

    Z barvami se srečujemo na vsakem koraku. Mogoče se njihovega vpliva ne zavedamo povsem, vendar nam lahko že pogled na določeno barvo dvigne ali pokvari razpoloženje. Barve imajo zelo velik vpliv na človeka in v nas prebujajo različna čustva. Nekatere barve so pozitivne in nas osrečujejo, druge pa na nas delujejo negativno. Ravno zaradi tega je tudi za oblikovalce embalaže zelo pomembno, da vnaprej predvidijo, kako se bodo potencialni porabniki njihovega izdelka odzivali na njihovo embalažo. P...

  13. IZOBRAŽEVANJE NA DOMU - ŠTUDIJA PRIMERA

    OpenAIRE

    Križan, Urška

    2014-01-01

    V teoretičnem delu se skozi literaturo seznanjamo z zakoni, ki na območju Republike Slovenije urejajo izobraževanje na domu, pa tudi s smernicami, ki veljajo na področju organiziranosti takega pouka. Po enem tednu, ki smo ga preživeli na domačiji skupaj s tremi šoloobveznimi otroki, ki se šolajo na domu, ugotavljamo, da je izvajanje izobraževanja na domu zmeraj v skladu z zakoni in pogosto v skladu s smernicami.

  14. Effects of non-uniform root zone salinity on water use, Na+ recirculation, and Na+ and H+ flux in cotton.

    Science.gov (United States)

    Kong, Xiangqiang; Luo, Zhen; Dong, Hezhong; Eneji, A Egrinya; Li, Weijiang

    2012-03-01

    A new split-root system was established through grafting to study cotton response to non-uniform salinity. Each root half was treated with either uniform (100/100 mM) or non-uniform NaCl concentrations (0/200 and 50/150 mM). In contrast to uniform control, non-uniform salinity treatment improved plant growth and water use, with more water absorbed from the non- and low salinity side. Non-uniform treatments decreased Na(+) concentrations in leaves. The [Na(+)] in the '0' side roots of the 0/200 treatment was significantly higher than that in either side of the 0/0 control, but greatly decreased when the '0' side phloem was girdled, suggesting that the increased [Na(+)] in the '0' side roots was possibly due to transportation of foliar Na(+) to roots through phloem. Plants under non-uniform salinity extruded more Na(+) from the root than those under uniform salinity. Root Na(+) efflux in the low salinity side was greatly enhanced by the higher salinity side. NaCl-induced Na(+) efflux and H(+) influx were inhibited by amiloride and sodium orthovanadate, suggesting that root Na(+) extrusion was probably due to active Na(+)/H(+) antiport across the plasma membrane. Improved plant growth under non-uniform salinity was thus attributed to increased water use, reduced leaf Na(+) concentration, transport of excessive foliar Na(+) to the low salinity side, and enhanced Na(+) efflux from the low salinity root.

  15. Synthesis of Na-A and/or Na-X zeolite/porous carbon composites from carbonized rice husk

    Science.gov (United States)

    Katsuki, Hiroaki; Komarneni, Sridhar

    2009-07-01

    Na-A and/or Na-X zeolite/porous carbon composites were prepared under hydrothermal conditions by NaOH dissolution of silica first from carbonized rice husk followed by addition of NaAlO 2 and in situ crystallization of zeolites i.e., using a two-step process. When a one-step process was used, both Na-A and Na-X zeolites crystallized on the surface of carbon. Na-A or Na-X zeolite crystals were prepared on the porous carbonized rice husk at 90 °C for 2-6 h by changing the SiO 2/Al 2O 3, H 2O/Na 2O and Na 2O/SiO 2 molar ratios of precursors in the two-step process. The surface area and NH 4+-cation exchange capacity (CEC) of Na-A zeolite/porous carbon were found to be 171 m 2/g and 506 meq/100 g, respectively, while those of Na-X zeolite/porous carbon composites were 676 m 2/g and 317 meq/100 g, respectively. Na-A and Na-X zeolites are well-known microporous and hydrophilic materials while carbonized rice husk was found to be mesoporous (pores of ˜3.9 nm) and hydrophobic. These hybrid microporous-mesoporous and hydrophilic-hydrophobic composites are expected to be useful for decontamination of metal cations as well as organic contaminants simultaneously.

  16. Batrachotoxin-activated Na+ channels in planar lipid bilayers. Competition of tetrodotoxin block by Na+.

    Science.gov (United States)

    Moczydlowski, E; Garber, S S; Miller, C

    1984-11-01

    Single Na+ channels from rat skeletal muscle plasma membrane vesicles were inserted into planar lipid bilayers formed from neutral phospholipids and were observed in the presence of batrachotoxin. The batrachotoxin-modified channel activates in the voltage range -120 to -80 mV and remains open almost all the time at voltages positive to -60 mV. Low levels of tetrodotoxin (TTX) induce slow fluctuations of channel current, which represent the binding and dissociation of single TTX molecules to single channels. The rates of association and dissociation of TTX are both voltage dependent, and the association rate is competitively inhibited by Na+. This inhibition is observed only when Na+ is increased on the TTX binding side of the channel. The results suggest that the TTX receptor site is located at the channel's outer mouth, and that the Na+ competition site is not located deeply within the channel's conduction pathway.

  17. High-temperature phases of NaNbO3 and NaTaO3.

    Science.gov (United States)

    Darlington; Knight

    1999-02-01

    The high-temperature phases of the perovskites sodium niobate, NaNbO(3), and sodium tantalate, NaTaO(3), have been re-examined using the high-resolution powder diffractometer HRPD at the ISIS neutron spallation source; the two materials show the same sequence of phases with tilted octahedra. Diffraction patterns were measured every 5 K allowing structural changes with temperature within a single phase to be determined for the first time. Previous structure determinations within one phase had been performed at a single temperature only. The octahedra are tilted about pseudocubic directions and are also deformed; the magnitude of the deformation is shown to be proportional to the square of the angle of tilt as expected from a phenomenological theory applied to such transitions. The structures of NaNbO(3) between 753 and 793 K and of NaTaO(3) below 758 K are not as reported in the literature.

  18. Transmural gradients in Na/K pump activity and [Na+]I in canine ventricle.

    Science.gov (United States)

    Gao, J; Wang, W; Cohen, I S; Mathias, R T

    2005-09-01

    There are well-documented differences in ion channel activity and action potential shape between epicardial (EPI), midmyocardial (MID), and endocardial (ENDO) ventricular myocytes. The purpose of this study was to determine if differences exist in Na/K pump activity. The whole cell patch-clamp was used to measure Na/K pump current (I(P)) and inward background Na(+)-current (I(inb)) in cells isolated from canine left ventricle. All currents were normalized to membrane capacitance. I(P) was measured as the current blocked by a saturating concentration of dihydro-ouabain. [Na(+)](i) was measured using SBFI-AM. I(P)(ENDO) (0.34 +/- 0.04 pA/pF, n = 17) was smaller than I(P)(EPI) (0.68 +/- 0.09 pA/pF, n = 38); the ratio was 0.50 with I(P)(MID) being intermediate (0.53 +/- 0.13 pA/pF, n = 19). The dependence of I(P) on [Na(+)](i) or voltage was essentially identical in EPI and ENDO (half-maximal activation at 9-10 mM [Na(+)](i) or approximately -90 mV). Increasing [K(+)](o) from 5.4 to 15 mM caused both I(P)(ENDO) and I(P)(EPI) to increase, but the ratio remained approximately 0.5. I(inb) in EPI and ENDO were nearly identical ( approximately 0.6 pA/pF). Physiological [Na(+)](i) was lower in EPI (7 +/- 2 mM, n = 31) than ENDO (12 +/- 3 mM, n = 29), with MID being intermediate (9 +/- 3 mM, n = 22). When cells were paced at 2 Hz, [Na(+)](i) increased but the differences persisted (ENDO 14 +/- 3 mM, n = 10; EPI 9 +/- 2 mM, n = 10; and MID intermediate, 11 +/- 2 mM, n = 9). Based on these results, the larger I(P) in EPI appears to reflect a higher maximum turnover rate, which implies either a larger number of active pumps or a higher turnover rate per pump protein. The transmural gradient in [Na(+)](i) means physiological I(P) is approximately uniform across the ventricular wall, whereas transporters that utilize the transmembrane electrochemical gradient for Na(+), such as Na/Ca exchange, have a larger driving force in EPI than ENDO.

  19. Isotope separation of 22Na and 24Na with using light induced drift effect

    International Nuclear Information System (INIS)

    Hradecny, C.; Tethal, T.; Ermolaev, I.M.; Zemlyanoj, S.G.; Zuzaan, P.

    1993-01-01

    The LIDIS (Light Drift Isotope Separation) separator without a gas flow is discussed. It is shown, that atomization degree of the separated isotopes limited real separation coefficient. The better buffer gas purification allowed to increase the experimental separation factor of 22 Na and 24 Na isotopes up to 25. The new experimental set up allow to increase the separation efficiency up to 50%. 12 refs.; 5 figs

  20. Intracellular Na+ regulation of Na+ pump sites in cultured vascular smooth muscle cells

    International Nuclear Information System (INIS)

    Allen, J.C.; Navran, S.S.; Seidel, C.L.; Dennison, D.K.; Amann, J.M.; Jemelka, S.K.

    1989-01-01

    Enzymatically dispersed cells from canine saphenous vein and femoral artery were grown in fetal calf serum and studied at day 0 (freshly dispersed) through confluence in primary culture. Intracellular Na levels (Nai), but not intracellular K (Ki), were increased after 24 h in culture and then decreased to a steady state by 4 days. Na+ pump site number [( 3 H] ouabain binding) increased through day 3 and remained elevated. Nai was still elevated at 2 days when the Na+ pump site number began to increase. Total pump turnover (maximum ouabain-inhibited 86 Rb uptake) reflected the increase in Na+ pump site number. These key events precede the observed increases in both protein production and cellular proliferation. If the same cells are maintained in defined medium, without fetal calf serum, Nai, Ki, and the number of [ 3 H]ouabain binding sites do not change with time. These data are consistent with the suggestion that the initial mitogenic response of vascular smooth muscle cells to fetal calf serum involves an increased Na+ influx, and a Nai accumulation, caused by low Na+ pump density. The synthesis of new pump sites effects a decrease in the accumulated Nai, which may be related to cell proliferation

  1. Na+-NQR (Na+-translocating NADH:ubiquinone oxidoreductase) as a novel target for antibiotics.

    Science.gov (United States)

    Dibrov, Pavel; Dibrov, Elena; Pierce, Grant N

    2017-09-01

    The recent breakthrough in structural studies on Na+-translocating NADH:ubiquinone oxidoreductase (Na+-NQR) from the human pathogen Vibrio cholerae creates a perspective for the systematic design of inhibitors for this unique enzyme, which is the major Na+ pump in aerobic pathogens. Widespread distribution of Na+-NQR among pathogenic species, its key role in energy metabolism, its relation to virulence in different species as well as its absence in eukaryotic cells makes this enzyme especially attractive as a target for prospective antibiotics. In this review, the major biochemical, physiological and, especially, the pharmacological aspects of Na+-NQR are discussed to assess its 'target potential' for drug development. A comparison to other primary bacterial Na+ pumps supports the contention that NQR is a first rate prospective target for a new generation of antimicrobials. A new, narrowly targeted furanone inhibitor of NQR designed in our group is presented as a molecular platform for the development of anti-NQR remedies. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  2. Active transport of Na/sup +/ by reconstituted Na,K-ATPase

    Energy Technology Data Exchange (ETDEWEB)

    Boldyrev, A.A.; Svinukhova, I.A.

    1987-02-20

    The ability of ATP, CTP, ITP, GTP, and UTP to support ouabain-sensitive accumulation of Na/sup +/ by proteoliposomes with a reconstituted Na/K-pump was investigated. At a low (Na/sup +/)/(K/sup +/) ratio in the medium (20 mM/50 mM), a correlation is observed between the proton-accepting capacity of the nucleotide and its effectiveness as a substrate of active transport. To test the hypothesis of the importance of the presence of a negative charge in the 1-position of the purine (3-pyrimidine) base of the nucleotide for mutual transitions between the Na- and K-conformations of Na,K-ATPase they used two analogs of ATP: N/sub 1/-hydroxy-ATP, possessing proton acceptor capacity, and N/sub 1/-methoxy-ATP, in the molecule of which the negative charge is quenched by a methyl group. The first substrate supports active accumulation of Na/sup +/ in proteoliposomes at the same rate as ATP, whereas the second substrate is relatively ineffective.

  3. Hidroginástica na terceira idade

    Directory of Open Access Journals (Sweden)

    Karla Campos de Paula

    1998-02-01

    Full Text Available O processo de envelhecimento no indivíduo saudável está relacionado com inúmeras alterações psicológicas e físicas que interferem na área motora, concorrendo para a inatividade e contribuindo para o aparecimento e agravamento de determinadas doenças, além de influenciar negativamente a realização das atividades de vida diária. Portanto, a prática de atividade física é fundamental para o idoso, não só na prevenção de doenças como na reabilitação de suas habilidades motoras, promovendo um estilo de vida saudável que é fator preponderante para a melhoria da qualidade de vida. Contudo, algumas precauções devem ser adotadas na prescrição da atividade direcionada para o idoso, a fim de que esta seja segura e prazerosa. Dentre os exercícios mais adequados aos idosos estão a caminhada, o ciclismo, a natação e a hidroginástica. Devido a sua grande procura, a hidroginástica vem aumentando o número de adeptos na terceira idade. Ela propicia ao idoso o aumento de sua capacidade aeróbia, força muscular, flexibilidade articular e o treinamento de habilidades específicas como equilíbrio e coordenação motora. Soma-se ainda o fato de esta atividade oferecer ambiente de relaxamento e incentivo ao contato social, atuando no combate ao estresse, depressão, na melhoria da autopercepção corporal e da auto-estima. Devemos, então, estar atentos às particularidades da hidroginástica, a fim de aproveitar todas as vantagens que esta oferece para o programa de exercícios direcionado para a terceira idade.

  4. Agmag Igbo dka Ngwar n'kwalite Ezi Nchekwa na Nkwsiike haobodo

    African Journals Online (AJOL)

    Ka Najira nwerechara onwe ya n'af 1960, olileanya tt mamala ya b na ihe ga-adz mma. Mana ka oge na-aga, a chptara na ihe na-akawanye nj. Usoro chch d iche iche daptara. Nd am na nd nkt achala mana nd gara n'ihu na-akawanye nj. O bu ihe doro anya na chch ha b nke nchgbu na fnfju akpa. N'agbanyegh na ...

  5. Transport of Na48 Drift Chambers to Dubna

    CERN Multimedia

    GOLOVATYUK, V

    2010-01-01

    On 22 July, in the occasion of the departure of the Na48 Drift Chambers from CERN, Mikhail Itkis (acting Director of the JIINR) and Rolf Heuer (CERN Director General) visited the NA62 experimental area.

  6. Angiotensin II-induced hypertension increases plasma membrane Na pump activity by enhancing Na entry in rat thick ascending limbs.

    Science.gov (United States)

    Gonzalez-Vicente, Agustin; Garvin, Jeffrey L

    2013-11-01

    Thick ascending limbs (TAL) reabsorb 30% of the filtered NaCl load. Na enters the cells via apical Na-K-2Cl cotransporters and Na/H exchangers and exits via basolateral Na pumps. Chronic angiotensin II (ANG II) infusion increases net TAL Na transport and Na apical entry; however, little is known about its effects on the basolateral Na pump. We hypothesized that in rat TALs Na pump activity is enhanced by ANG II-infusion, a model of ANG II-induced hypertension. Rats were infused with 200 ng·kg(-1)·min(-1) ANG II or vehicle for 7 days, and TAL suspensions were obtained. We studied plasma membrane Na pump activity by measuring changes in 1) intracellular Na (Nai) induced by ouabain; and 2) ouabain-sensitive oxygen consumption (QO2). We found that the ouabain-sensitive rise in Nai in TALs from ANG II-infused rats was 12.8 ± 0.4 arbitrary fluorescent units (AFU)·mg(-1)·min(-1) compared with only 9.9 ± 1.1 AFU·mg(-1)·min(-1) in controls (P Na pump expression, the number of Na pumps in the plasma membrane, or the affinity for Na. When furosemide (1.1 mg·kg(-1)·day(-1)) was coinfused with ANG II, no increase in plasma membrane Na pump activity was observed. We concluded that in ANG II-induced hypertension Na pump activity is increased in the plasma membrane of TALs and that this increase is caused by the chronically enhanced Na entry occurring in this model.

  7. Rescue of Na+ affinity in aspartate 928 mutants of Na+,K+-ATPase by secondary mutation of glutamate 314.

    Science.gov (United States)

    Holm, Rikke; Einholm, Anja P; Andersen, Jens P; Vilsen, Bente

    2015-04-10

    The Na(+),K(+)-ATPase binds Na(+) at three transport sites denoted I, II, and III, of which site III is Na(+)-specific and suggested to be the first occupied in the cooperative binding process activating phosphorylation from ATP. Here we demonstrate that the asparagine substitution of the aspartate associated with site III found in patients with rapid-onset dystonia parkinsonism or alternating hemiplegia of childhood causes a dramatic reduction of Na(+) affinity in the α1-, α2-, and α3-isoforms of Na(+),K(+)-ATPase, whereas other substitutions of this aspartate are much less disruptive. This is likely due to interference by the amide function of the asparagine side chain with Na(+)-coordinating residues in site III. Remarkably, the Na(+) affinity of site III aspartate to asparagine and alanine mutants is rescued by second-site mutation of a glutamate in the extracellular part of the fourth transmembrane helix, distant to site III. This gain-of-function mutation works without recovery of the lost cooperativity and selectivity of Na(+) binding and does not affect the E1-E2 conformational equilibrium or the maximum phosphorylation rate. Hence, the rescue of Na(+) affinity is likely intrinsic to the Na(+) binding pocket, and the underlying mechanism could be a tightening of Na(+) binding at Na(+) site II, possibly via movement of transmembrane helix four. The second-site mutation also improves Na(+),K(+) pump function in intact cells. Rescue of Na(+) affinity and Na(+) and K(+) transport by second-site mutation is unique in the history of Na(+),K(+)-ATPase and points to new possibilities for treatment of neurological patients carrying Na(+),K(+)-ATPase mutations. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  8. Characterization of Na+-linked and Na+-independent Cl-/HCO3- exchange systems in Chinese hamster lung fibroblasts

    International Nuclear Information System (INIS)

    Cassel, D.; Scharf, O.; Rotman, M.; Cragoe, E.J. Jr.; Katz, M.

    1988-01-01

    The PS120 variant of Chinese hamster lung fibroblasts which lacks Na + /H + exchange activity was used to investigate bicarbonate transport systems and their role in intracellular pH (pH/sub i/) regulation. When pH/sub i/ was decreased by acid load, bicarbonate caused pH/sub i/ increase and stimulated 36 Cl - efflux from the cells, both in a Na + -dependent manner. These results together with previous findings that bicarbonate stimulates 22 Na + uptake in PS120 cells demonstrate the presence of a Na + -linked Cl - /HCO 3 - exchange system. In cells with normal initial pH/sub i/, bicarbonate caused Na + -independent pH/sub i/ increase in Cl - -free solutions and stimulated Na + -independent 36 Cl - efflux, indicating that a Na + -independent Cl - /HCO 3 - exchanger is also present in the cell. Na + -linked and Na + -independent Cl - /HCO 3- exchange is apparently mediated by two distinct systems, since a [(tetrahydrofluorene-7-yl)oxy]acetic acid derivative selectively inhibits the Na + -independent exchanger. An additional distinctive features is a 10-fold lower affinity for chloride of the Na + -linked exchanger. The Na + -linked and Na + -independent Cl - /HCO 3 - exchange systems are likely to protect the cell from acid and alkaline load, respectively

  9. The two C-terminal tyrosines stabilize occluded Na/K pump conformations containing Na or K ions.

    Science.gov (United States)

    Vedovato, Natascia; Gadsby, David C

    2010-07-01

    Interactions of the three transported Na ions with the Na/K pump remain incompletely understood. Na/K pump crystal structures show that the extended C terminus of the Na,K-adenosine triphosphatase (ATPase) alpha subunit directly contacts transmembrane helices. Deletion of the last five residues (KETYY in almost all Na/K pumps) markedly lowered the apparent affinity for Na activation of pump phosphorylation from ATP, a reflection of cytoplasmic Na affinity for forming the occluded E1P(Na3) conformation. ATPase assays further suggested that C-terminal truncations also interfere with low affinity Na interactions, which are attributable to extracellular effects. Because extracellular Na ions traverse part of the membrane's electric field to reach their binding sites in the Na/K pump, their movements generate currents that can be monitored with high resolution. We report here electrical measurements to examine how Na/K pump interactions with extracellular Na ions are influenced by C-terminal truncations. We deleted the last two (YY) or five (KESYY) residues in Xenopus laevis alpha1 Na/K pumps made ouabain resistant by either of two kinds of point mutations and measured their currents as 10-mM ouabain-sensitive currents in Xenopus oocytes after silencing endogenous Xenopus Na/K pumps with 1 microM ouabain. We found the low affinity inhibitory influence of extracellular Na on outward Na/K pump current at negative voltages to be impaired in all of the C-terminally truncated pumps. Correspondingly, voltage jump-induced transient charge movements that reflect pump interactions with extracellular Na ions were strongly shifted to more negative potentials; this signals a several-fold reduction of the apparent affinity for extracellular Na in the truncated pumps. Parallel lowering of Na affinity on both sides of the membrane argues that the C-terminal contacts provide important stabilization of the occluded E1P(Na3) conformation, regardless of the route of Na ion entry into the

  10. The rapid-onset dystonia parkinsonism mutation D923N of the Na+, K+-ATPase alpha3 isoform disrupts Na+ interaction at the third Na+ site.

    Science.gov (United States)

    Einholm, Anja Pernille; Toustrup-Jensen, Mads S; Holm, Rikke; Andersen, Jens Peter; Vilsen, Bente

    2010-08-20

    Rapid-onset dystonia parkinsonism (RDP), a rare neurological disorder, is caused by mutation of the neuron-specific alpha3-isoform of Na(+), K(+)-ATPase. Here, we present the functional consequences of RDP mutation D923N. Relative to the wild type, the mutant exhibits a remarkable approximately 200-fold reduction of Na(+) affinity for activation of phosphorylation from ATP, reflecting a defective interaction of the E(1) form with intracellular Na(+). This is the largest effect on Na(+) affinity reported so far for any Na(+), K(+)-ATPase mutant. D923N also affects the interaction with extracellular Na(+) normally driving the E(1)P to E(2)P conformational transition backward. However, no impairment of K(+) binding was observed for D923N, leading to the conclusion that Asp(923) is specifically associated with the third Na(+) site that is selective toward Na(+). The crystal structure of the Na(+), K(+)-ATPase in E(2) form shows that Asp(923) is located in the cytoplasmic half of transmembrane helix M8 inside a putative transport channel, which is lined by residues from the transmembrane helices M5, M7, M8, and M10 and capped by the C terminus, recently found involved in recognition of the third Na(+) ion. Structural modeling of the E(1) form of Na(+), K(+)-ATPase based on the Ca(2+)-ATPase crystal structure is consistent with the hypothesis that Asp(923) contributes to a site binding the third Na(+) ion. These results in conjunction with our previous findings with other RDP mutants suggest that a selective defect in the handling of Na(+) may be a general feature of the RDP disorder.

  11. Urgências reprodutivas na cadela

    OpenAIRE

    Costa, Teresa Isabel Rodrigues da

    2010-01-01

    Dissertação de Mestrado Integrado em Medicina Veterinária As urgências reprodutivas ocorrem com frequência na prática clínica, estando o seu desfecho favorável associado a um diagnóstico e intervenção céleres. Na cadela, consideram-se urgências reprodutivas a distócia, a piómetra, o prolapso uterino, a torção uterina, a tetania puerperal, a metrite e a mastite. Esta dissertação tem por base a análise dos dados referentes à casuística de urgências reprodutivas em cadelas veri...

  12. Jogos teatrais na escola pública

    Directory of Open Access Journals (Sweden)

    Ricardo Ottoni Vaz Japiassu

    1998-07-01

    Full Text Available O artigo apresenta os resultados parciais de pesquisa etnográfica que acompanha aspectos do desenvolvimento cultural de pré-adolescentes com a linguagem teatral em classe multisseriada, através do ensino regular de Teatro, em escola de ensino fundamental da rede pública estadual de São Paulo-SP. Os dados obtidos permitem afirmar que a linguagem cênica contribui na conscientização das novas possibilidades de significação da palavra na prática discursiva.The article shows partial results of ethnographic research in which kids are observed in their cultural development process with theater classes in public school education in São Paulo/Brazil. The data colected indicates that the use of theater games in school education helps students to be aware of a word’s new meaning possibilities in human comunication.

  13. HUME E O EMPIRISMO NA MORAL

    Directory of Open Access Journals (Sweden)

    Adriano Naves de Brito

    2007-12-01

    Full Text Available O que pretendo defender neste texto é que uma posição empirista na moral é compatível com uma pretensão de validade intersubjetiva de juízos morais. Essa pretensão deve, nesse caso, estar calcada na naturalização dos fundamentos da moralidade, mas tem de conviver com limites acerca da justificação de enunciados de valor. Para defender esse ponto, sirvo-me da filosofia moral de Hume, como ele a expôs no seu texto Uma investigação sobre os princípios da moral. No que diz respeito à filosofia de Hume, o objetivo deste texto é explicitar o caráter empírico seja de seu método de investigação da moral, seja do princípio que para ela ele encontra.

  14. News from the NA61/SHINE experiment

    Science.gov (United States)

    Šuša, Tatjana

    2018-02-01

    The main goals of the NA61/SHINE experiment at the CERN SPS are the search for the critical point of strongly interacting matter and the study of the properties of the onset of deconfinement. These aims are pursued by performing a two-dimensional scan of the phase diagram of strongly interacting matter by varying the momentum and size of the colliding nuclei. This contribution summarises the latest results from the NA61/SHINE experiment, in particular, new results on spectra and yields of ϕ meson in p+p interactions at 40, 80 and 158 GeV/c and K+ and K- production in central Be+Be collisions at mid-rapidity. In addition, results on system size dependence of particle yield ratios and fluctuations are presented.

  15. NA62 experiment at CERN SPS

    Directory of Open Access Journals (Sweden)

    Kozhuharov Venelin

    2014-01-01

    Full Text Available The NA62 experiment at SPS is a continuation of the long standing CERN kaon physics program. The high statistics and the unprecedent precision allow to probe the Standard Model and test the description of the strong interactions at low energy. The final results on the the lepton universality test by measuring the ratio RK = Γ(K+ → e+ν/Γ(K+ → µ+ν and the study of the K± → π±γγ decay are presented. The major goal of the NA62 experiment is to perform a measurement of the Br(K+ → π+νν̄ with a precision of 10% in two years of data taking. The detector setup together with the analysis technique is described.

  16. Luz e tempo na melancolia I

    Directory of Open Access Journals (Sweden)

    Cláudio Soares Braga Furtado

    2009-12-01

    Full Text Available A comparação entre as artes possibilita figurar o tempo como elemento comum entre a gravura renascentista de Dürer, a escultura romana de Laocoonte e o conto de Guimarães Rosa. A partir da leitura dessas artes distantes em forma, meios, época e lugar, descobrem-se mistérios aludidos em sutis sinais, que, se ainda não despertos na consciência criativa, estimulam interpretações. O papel da luz como unificadora das entidades tempo/espaço restabelece o princípio clássico da ut pictura poesis na leitura moderna.

  17. Kaizen: Uma Metodologia Inovadora na Siderurgia

    Directory of Open Access Journals (Sweden)

    Hericson Estanislau Prata

    2017-04-01

    Full Text Available A racionalização do processo produtivo industrial, por meio da redução dos desperdícios e da modernização do processo produtivo, com a adoção do Sistema Toyota de Produção (Produção Enxuta, tem sido adotada por uma parte importante das indústrias no mundo. O objetivo deste artigo é descrever essa metodologia empregada pelo grupo de melhoria de fase intensiva adotado na Vallourec Tubos do Brasil S.A. Como resultado, verificou-se que o processo utilizado para a implantação de mudanças em curto prazo foi a semana intensiva, também conhecida como evento Kaizen na indústria automotiva.

  18. O Personal Trainer na Perspectiva do Marketing

    Directory of Open Access Journals (Sweden)

    Cibele Biehl Bossle

    2011-03-01

    Full Text Available Esse estudo apresenta mapeamento das referências dedicadas à formação do personal trainer em bases de dados eletrônicas. Essa garimpagem revelou baixa produção científica sobre o assunto e mostrou que na literatura sobre personal trainer predominam livros com linguagem corrente no mundo dos negócios. Esses achados nos levaram a indagar sobre a força do discurso físico-empresarial, especialmente o marketing, na constituição desta ocupação profissional. Jeremy Rifkin, Zygmunt Bauman, Paula Sibilia e Denise Sant'Anna permitiram visualizar que o marketing dirigido ao personal trainer tem como tarefa reinventar, ressignificar e "repaginar" esta modalidade de serviço em nome da sobrevivência no disputado mercado da vida ativa.

  19. New NA22 results on correlations

    International Nuclear Information System (INIS)

    De Wolf, E.A.

    1993-01-01

    Recent NA22 results from π + p and K + p inelastic interactions at √s = 22 GeV on invariant-mass and Q 2 -dependence of two- and three-particle factorial cumulants are discussed in relation to earlier intermittency studies. The absence of Bose-Einstein type correlations among identical particles, and too large resonance production rates, are responsible for the strong disagreements of models with intermittency data. 6 figs., 17 refs

  20. NA35: sulphur-gold collision

    CERN Multimedia

    1991-01-01

    In this image the real particles produced by the collision of a 6400 GeV sulphur ion with a gold target can be seen as they pass through a streamer chamber. Streamer chambers consist of a gas chamber through which a strong pulsed electric field is passed, creating sparks as a charged particle passes through it. The NA35 experiment, which was in operation in the 1980s, was part of CERN's ongoing heavy ion project.

  1. Die Calvinistiese Sondagbeskouing met spesiale verwysing na ...

    African Journals Online (AJOL)

    omver te werp. Aan die ander kant het die orde en vrede in die kerk dit wel ook nodig gemaak om 'n dag vir gebruik van die diens van die Here af te sonder. Calvyn se insigte in verband met die oorgang van die Sabbat na die Sondag, is die insigte wat as die eg reformatoriese behoue gebly het. Haitjema (1961:249) sê in.

  2. Sources of Na for the Io atmosphere

    Science.gov (United States)

    Burnett, D. S.; Ellis, Susan B.; Rice, A.; Epstein, S.

    1993-01-01

    The physics and geology of Io have been extensively studied, but there has been little discussion of the chemistry. Relatively little is known about Io chemistry, but there are constraints. Further, it will be a long time before improvements will result from direct observation, given the severe difficulties with the Galileo mission. Via laboratory simulation experiments, plausible thermochemical and photochemical processes which determine the nature and amounts of surface constituents of Io are explored. The well-known density of Io shows that the planet overall is rocky. Because the orbit of Io is well within the magnetosphere of Jupiter and because Io only has a thin, transient SO2 atmosphere, the surface is continually sputtered with magnetospheric ions. Complex processes ionize and accelerate the Io surface atoms to keV and MeV energies. Remarkably, only S, O, and Na ions were found by Voyager. Sputtering also produces an atomic cloud of Na and S (O not observable) with a trace of K. Both gaseous and solid SO2 are known from spectroscopic studies. A trace of H2S and possibly CO2 are present. Geologic features are interpreted in terms of elemental S, but there is no direct evidence for this constituent. We thus have a rocky planet which does not have rocks on the surface. Our general goal is to understand the cycling of Na, S, and O through the crust and atmosphere on present-day Io and to understand how Io evolved to this state. A specific objective was to determine the phases on the surface which are the source of the Na in the atmosphere of Io.

  3. The NA48 liquid krypton calorimeter

    CERN Document Server

    Gorini, B

    1997-01-01

    The NA48 collaboration goal is to measure the CP violation parameter Re(ɛl/ɛ) at the level of 2 × 10−4. The neutral Kaon decays will be reconstructed by an electromagnetic liquid Krypton calorimeter with fine granularity and a volume almost totally sensible, to obtain excellent position and energy resolution, as well as time resolution. A description of the detector, results from tests of a prototype and the status of the final calorimeter are reported.

  4. Prototype calorimeters for the NA3 experiment

    CERN Multimedia

    1975-01-01

    The NA3 Experiment was set-up on the North Area of the SPS by the CERN/ Ecole Polytechnique/College de France/ Orsay/Saclay Collaboration, to study high transverse momentum leptons and hadrons from hadron collisions. The calorimeters measured the energy of hadrons (prototype on the right) and leptons (prototype on the left). They used a new type of plastic scintillator (plexipop). (see CERN Courier of November 1975) energy (prototype on the right)

  5. Maendeleo ya Fasihi ya Kiswahili ya Watoto nchini Tanzania na ...

    African Journals Online (AJOL)

    Fasihi ya Kiswahili ya watoto kama taaluma haina muda mrefu katika historia ya fasihi ya Kiswahili. Ikilinganishwa na fasihi ya watu wazima ambayo ilianza muda mrefu, na pia tafiti nyingi kufanyika katika mataifa mengi, fasihi ya watoto inaonekana kuwa imetelekezwa kwa muda mrefu kutokana na kutokupewa umuhimu ...

  6. Dhima za Mbinu Linganishi katika Kuhusisha Lugha na Lahaja ...

    African Journals Online (AJOL)

    Lengo la makala hii ni kujadili dhima za Mbinu Linganishi katika kuhusisha lugha na lahaja. Data za makala hii zilikusanywa kwa kutumia mbinu mbalimbali ambazo ni usaili, ushuhudiaji, hojaji na majadiliano katika majopo. Utafiti ulifanyika Tanzania Bara hususan Mkoani Mtwara na Tanzania Visiwani katika maeneo ya ...

  7. Glial Na(+) -dependent ion transporters in pathophysiological conditions.

    Science.gov (United States)

    Boscia, Francesca; Begum, Gulnaz; Pignataro, Giuseppe; Sirabella, Rossana; Cuomo, Ornella; Casamassa, Antonella; Sun, Dandan; Annunziato, Lucio

    2016-10-01

    Sodium dynamics are essential for regulating functional processes in glial cells. Indeed, glial Na(+) signaling influences and regulates important glial activities, and plays a role in neuron-glia interaction under physiological conditions or in response to injury of the central nervous system (CNS). Emerging studies indicate that Na(+) pumps and Na(+) -dependent ion transporters in astrocytes, microglia, and oligodendrocytes regulate Na(+) homeostasis and play a fundamental role in modulating glial activities in neurological diseases. In this review, we first briefly introduced the emerging roles of each glial cell type in the pathophysiology of cerebral ischemia, Alzheimer's disease, epilepsy, Parkinson's disease, Amyotrophic Lateral Sclerosis, and myelin diseases. Then, we discussed the current knowledge on the main roles played by the different glial Na(+) -dependent ion transporters, including Na(+) /K(+) ATPase, Na(+) /Ca(2+) exchangers, Na(+) /H(+) exchangers, Na(+) -K(+) -Cl(-) cotransporters, and Na(+) - HCO3- cotransporter in the pathophysiology of the diverse CNS diseases. We highlighted their contributions in cell survival, synaptic pathology, gliotransmission, pH homeostasis, and their role in glial activation, migration, gliosis, inflammation, and tissue repair processes. Therefore, this review summarizes the foundation work for targeting Na(+) -dependent ion transporters in glia as a novel strategy to control important glial activities associated with Na(+) dynamics in different neurological disorders. GLIA 2016;64:1677-1697. © 2016 Wiley Periodicals, Inc.

  8. Muundo wa Mashairi katika Diwani ya Mnyampala (1965) na Nafasi ...

    African Journals Online (AJOL)

    Makala hii pia inadadisi namna mbinu za kimuundo zilivyofanikisha usawiri na ubainishaji wa falsafa ya mtunzi kuhusu ushairi wa Kiswahili na nafasi ya ushairi katika jamii. Makala imeanza kwa kugusia usuli wa historia ya ushairi wa Kiswahili, historia fupi ya maisha ya Mathias Mnyampala na nadharia yake kuhusu ...

  9. Ujitokezaji wa Viambishi Njeo na Athari zake Kifonolojia katika ...

    African Journals Online (AJOL)

    Chanzo cha data za utafiti huu ni vitabu mbalimbali vinavyohusu lugha ya Shimalila, navyo vimeandikwa na watu mbalimbali wa jamii ya Shimalila ambao malengo yao ni kutafsiri Biblia kutoka katika lugha ya Kiswahili kwenda katika lugha ya Shimalila. Pia, data nyingine zimetokana na hojaji pamoja na usaili wa moja ...

  10. BAKITA NA LUGHA YA KUFUNDISHIA | BAKITA | Kioo cha Lugha

    African Journals Online (AJOL)

    BAKITA NA LUGHA YA KUFUNDISHIA. Baraza la Kiswahili la Taifa BAKITA. Abstract. Makala haya yanatoa maelezo mafupi ya matukio muhimu kuhusu suala la kutumia Kiswahili kama lugha ya kufundishia sekondari na vyuo katika kipindi baina ya mwaka 1967 mpaka 2000. Makala yanaeleza dhima na shughuli za ...

  11. Hadhi ya Kiswahili na watumiaji wake katika utandawazi ...

    African Journals Online (AJOL)

    Katika Taifa la Tanzania, mathalani, Kiswahili kimewakusanya na kuwajumuisha pamoja watu wa makabila zaidi ya 150 – kikitumika kama lugha ya mawasiliano inayoeleweka na watu wote. Hii si ajabu, ikizingatiwa kuwa, kwa silika yake, Kiswahili ni lugha unganishi, yaani yenye hulka ya kuunganisha, na siyo ya ...

  12. Hydrophilic C terminus of Salicornia europaea vacuolar Na/H ...

    Indian Academy of Sciences (India)

    Plant vacuolar Na+/H+ antiporters play important roles in cellular ion homeostasis,vacuolar pH regulation and sequestration of Na+ ions into the vacuole. Previous research showed that hydrophilic C-terminal region of Arabidopsis AtNHX1 negatively regulates the Na+/H+ transporting activity. In this study, we truncated the ...

  13. Fanfiction: uma escrita criativa na web

    Directory of Open Access Journals (Sweden)

    Daniele Alves Alencar

    Full Text Available RESUMO Estudo das fanfictions como uma prática de incentivo à leitura e produção de textos ficcionais na web. Por meio de pesquisa exploratória, bibliográfica e qualitativa foi desenvolvido o assunto para a área daCiência da Informação. Utiliza o site “Nyah! Fanfiction” como fonte de informação sobre as fanfictions e para aplicação de questionáriocomo auxílio na investigação do comportamento dos fanfiqueiros do site. O artigo mostra o que são as fanfictions, descreve a forma diferenciada que o ficwriterl ê o texto original para a produção da história, e apresenta o site “Nyah! Fanfiction” não apenas como depositário de fanfictions, mas também informa como essa prática pode se tornar mais que um passatempo, por explorar a imaginação, estimular a criação de textos, e assim intensificar a prática de leitura e escrita entre os jovens. O assunto estudado ainda é considerado novo na área de Biblioteconomia, portanto se faz necessário o desenvolvimento de mais pesquisas abordando o tema fanfiction.

  14. Cultura Política na Antiguidade

    Directory of Open Access Journals (Sweden)

    José Petrúcio Farias Júnior

    2009-06-01

    Full Text Available

    Pretendemos discutir nesse artigo algumas implicações do termo cultura política na Antiguidade, especificamente, na sociedade romana imperial. Dessa forma, acreditamos que as considerações que apresentaremos a seguir contribuam para reflexão da utilização desse termo, produto das investigações contemporâneas, sobre os estudos das sociedades antigas. Para a historiadora Profa. Dra. Margarida Maria de Carvalho, tais reflexões representam ainda uma lacuna na historiografia concernente a essa temática. Isso posto, discorreremos, inicialmente, sobre o conceito de cultura e seus desdobramentos para, em seguida, refletirmos sobre o viés interpretativo que fundamenta estudos históricos que se desenvolvem sob o beneplácito da linha de pesquisa intitulada História e Cultura Política.

  15. NaI(Tl) response functions

    International Nuclear Information System (INIS)

    Vega C, H. R.; Ortiz R, J. M.; Benites R, J. L.; De Leon M, H. A.

    2015-09-01

    The response functions of a NaI(Tl) detector have been estimated using Monte Carlo methods. Response functions were calculated for monoenergetic photon sources (0.05 to 3 MeV). Responses were calculated for point-like sources and for sources distributed in Portland cement cylinders. The responses were used to calculate the efficiency functions in term of photon energy. Commonly, sources used for calibration are point-like, and eventually sources to be measured have different features. In order to use the calibrated sources corrections due to solid angle, self-absorption and scattering, must be carried out. However, some of these corrections are not easy to perform. In this work, the calculated responses were used to estimate the detector efficiency of point-like sources, and sources distributed in Portland type cement. Samples of Portland paste were prepared and were exposed to photoneutrons produced by a 15 MV linac. Some of the elements in the cement were activated producing γ-emitting radionuclides that were measured with a NaI(Tl) gamma-ray spectrometer, that was calibrated with point-like sources. In order to determine the specific activity in the induced radioisotopes calculated efficiencies were used to make corrections due to the differences between the solid angle, photon absorption and photon scattering in the point-like calibration sources and the sources distributed in cement. During the interaction between photoneutrons and the cement samples three radioisotopes were induced: 56 Mn, 24 Na, and 28 Al. (Author)

  16. A CPL NA SOCIEDADE DO CONHECIMENTO

    Directory of Open Access Journals (Sweden)

    Patrisia Ciancio

    2009-07-01

    online tem sido pensada pela Comunidade dos Países de Língua Portuguesa (CPLP, que registra preocupação com sua entrada na sociedade do conhecimento nas atas das reuniões de chefes de Estado, e seus desdobramentos, ocorridas a cada dois anos. No entanto, faltam projetos concretos a esta proposta. O enquadramento teórico da pesquisa que se apresenta está no terreno flutuante da Lusofonia, que em sua descontinuidade territorial e fragmentação se projeta em alternativas “tecnoculturais”. As missões colonizadoras pontilharam um trajeto invisível. Esfera que, de algum modo, persiste e pode ser restaurada na criação de comunidades virtuais com uso de novas tecnologias para refazer este percurso, agora em concepção inversa, que privilegia o mosaico cultural dos povos. Um círculo virtual que pede por ser também virtuoso. O objetivo é delimitar bases para uma proposta prática de criação de novos canais de interação. Para alcançar tais constatações, a metodologia empregada foi uma análise documental que verifica os debates ao redor da comunicação ao longo de dez anos (1996 a 2006 na CPLP.

  17. NA64 Search for Dark Photons

    CERN Document Server

    Shiakas, Christos

    2017-01-01

    The NA64 experiment, known as P348 before official approval, was proposed to the CERN SPSC on January 2014 with main goal the search for the following decay modes A′ → invisible A′ → e−e+ (1) In March 2016 P348 was granted approval by the CERN Research Board and received the title NA64. Since having been promoted, the experiment has been conducting the searches the searches for the processes mentioned above at the CERN SPS. NA64 is a fixed target experiment which utilizes the active beam dump. The detection of rare processes is based on the missing energy techniques. Such techniques are used for particles whose interaction with the detector is very small, so that they escape the detection and carry away some energy. A significant missing energy in the experiment means that such particles are produced. The method of the search for the A′ → invisible decay is as follows. If the A′ exists it could be produced via the kinetic mixing with bremsstrahlung photons in the reaction of high-energy elec...

  18. Imunossupressores na Dermatologia Immunosuppressive agents in Dermatology

    Directory of Open Access Journals (Sweden)

    Aline Lopes Bressan

    2010-02-01

    Full Text Available Os imunossupressores são drogas que agem na divisão celular e têm propriedades anti-inflamatórias. Sendo assim, são essencialmente prescritos na prevenção de rejeição de transplantes e no tratamento das doenças autoimunes e inflamatórias crônicas, que, na Dermatologia, têm a psoríase como maior representante. Nesta sessão serão descritas as principais drogas imunossupressoras, com orientações para seu manejo adequado.Immunosupressants are drugs that act in cell division and have anti-inflammatory effects. Therefore, they are essentially prescribed in the prevention of transplant rejection and in the treatment of autoimmune disorders and chronic inflammatory diseases, whose main example in Dermatology is psoriasis. In this work the most important immunosuppressive drugs and orientation to properly administer them are going to be described.

  19. Resonances production from the NA60 experiment

    Directory of Open Access Journals (Sweden)

    De Falco A.

    2012-11-01

    Full Text Available The NA60 experiment at the CERN SPS has studied light vector meson production in In-In collisions at 158A GeV. The ϕ meson was detected via both the K+K− and the μ+μ− decay channels. The yields and inverse slope parameters of the mT spectra observed in the two channels are compatible within errors, different from the large discrepancies seen in Pb-Pb collisions between the hadronic (NA49 and dimuon (NA50 decay channels. In the invariant mass region 0.2 1 GeV, the excess is found to be prompt, with remarkable differences with respect to the Drell-Yan process. The Teff slope parameter, extracted from the transverse mass spectra, shows a rise with mass up to the ρ, followed by a sudden decline for higher masses. The former is consistent with radial flow of a hadronic source, while the latter suggests a dominantly partonic emission source.

  20. Envolvimento do sistema nervoso central na cisticercose

    Directory of Open Access Journals (Sweden)

    Aristides Cheto de Queiroz

    1979-03-01

    Full Text Available No estudo do envolvimento do SNC na cisticercose, verificou-se uma freqüência de 0,3%, sempre como achado incidental no estudo de rotina de autópsias; apenas um caso mostrou boa correlação com a presença de manifestações neurológicas. Esta freqüência que é baixa em relação ao que é observado em outras regiões do Brasil, mostra que a neurocisticercose não representa um grande problema na região. As reações do hospedeiro ao embrião do cisticerco foram sempre do tipo inflamatório crônico e fibrosante. Neste estudo ficou demonstrada a importância do método de impregnação pela prata (Grocott na identificação do esqueleto do cisticerco no interior de lesões fibrosantes e/ou calcificadas.

  1. Growth mechanism of NaClO 3 and NaBrO 3 crystals from aqueous ...

    Indian Academy of Sciences (India)

    A study of growth rates of NaClO3 and NaBrO3 has been carried out using a small growth cell by in situ observation. Normal growth rates of {100} faces of NaClO3 and {111} faces of NaBrO3 along ⟨ 110 ⟩ direction are measured under relatively high supersaturation ranging from 3–8%. In the initial stages of growth, {100}, ...

  2. Growth mechanism of NaClO3 and NaBrO3 crystals from aqueous ...

    Indian Academy of Sciences (India)

    A study of growth rates of NaClO3 and NaBrO3 has been carried out using a small growth cell by in situ observation. Normal growth rates of {100} faces of NaClO3 and {111} faces of NaBrO3 along ⟨ 110 ⟩ direction are measured under relatively high supersaturation ranging from 3–8%. In the initial stages of growth, {100}, ...

  3. Route, mechanism, and implications of proton import during Na+/K+ exchange by native Na+/K+-ATPase pumps.

    Science.gov (United States)

    Vedovato, Natascia; Gadsby, David C

    2014-04-01

    A single Na(+)/K(+)-ATPase pumps three Na(+) outwards and two K(+) inwards by alternately exposing ion-binding sites to opposite sides of the membrane in a conformational sequence coupled to pump autophosphorylation from ATP and auto-dephosphorylation. The larger flow of Na(+) than K(+) generates outward current across the cell membrane. Less well understood is the ability of Na(+)/K(+) pumps to generate an inward current of protons. Originally noted in pumps deprived of external K(+) and Na(+) ions, as inward current at negative membrane potentials that becomes amplified when external pH is lowered, this proton current is generally viewed as an artifact of those unnatural conditions. We demonstrate here that this inward current also flows at physiological K(+) and Na(+) concentrations. We show that protons exploit ready reversibility of conformational changes associated with extracellular Na(+) release from phosphorylated Na(+)/K(+) pumps. Reversal of a subset of these transitions allows an extracellular proton to bind an acidic side chain and to be subsequently released to the cytoplasm. This back-step of phosphorylated Na(+)/K(+) pumps that enables proton import is not required for completion of the 3 Na(+)/2 K(+) transport cycle. However, the back-step occurs readily during Na(+)/K(+) transport when external K(+) ion binding and occlusion are delayed, and it occurs more frequently when lowered extracellular pH raises the probability of protonation of the externally accessible carboxylate side chain. The proton route passes through the Na(+)-selective binding site III and is distinct from the principal pathway traversed by the majority of transported Na(+) and K(+) ions that passes through binding site II. The inferred occurrence of Na(+)/K(+) exchange and H(+) import during the same conformational cycle of a single molecule identifies the Na(+)/K(+) pump as a hybrid transporter. Whether Na(+)/K(+) pump-mediated proton inflow may have any physiological or

  4. Route, mechanism, and implications of proton import during Na+/K+ exchange by native Na+/K+-ATPase pumps

    Science.gov (United States)

    Vedovato, Natascia

    2014-01-01

    A single Na+/K+-ATPase pumps three Na+ outwards and two K+ inwards by alternately exposing ion-binding sites to opposite sides of the membrane in a conformational sequence coupled to pump autophosphorylation from ATP and auto-dephosphorylation. The larger flow of Na+ than K+ generates outward current across the cell membrane. Less well understood is the ability of Na+/K+ pumps to generate an inward current of protons. Originally noted in pumps deprived of external K+ and Na+ ions, as inward current at negative membrane potentials that becomes amplified when external pH is lowered, this proton current is generally viewed as an artifact of those unnatural conditions. We demonstrate here that this inward current also flows at physiological K+ and Na+ concentrations. We show that protons exploit ready reversibility of conformational changes associated with extracellular Na+ release from phosphorylated Na+/K+ pumps. Reversal of a subset of these transitions allows an extracellular proton to bind an acidic side chain and to be subsequently released to the cytoplasm. This back-step of phosphorylated Na+/K+ pumps that enables proton import is not required for completion of the 3 Na+/2 K+ transport cycle. However, the back-step occurs readily during Na+/K+ transport when external K+ ion binding and occlusion are delayed, and it occurs more frequently when lowered extracellular pH raises the probability of protonation of the externally accessible carboxylate side chain. The proton route passes through the Na+-selective binding site III and is distinct from the principal pathway traversed by the majority of transported Na+ and K+ ions that passes through binding site II. The inferred occurrence of Na+/K+ exchange and H+ import during the same conformational cycle of a single molecule identifies the Na+/K+ pump as a hybrid transporter. Whether Na+/K+ pump–mediated proton inflow may have any physiological or pathophysiological significance remains to be clarified. PMID

  5. VISIBILIDADE GAY NA ESCOLA: ESTUDANTES QUEER

    Directory of Open Access Journals (Sweden)

    Aline Ferraz da Silva

    2008-03-01

    Full Text Available Nesse artigo apresento as considerações e análises presentes na pesquisa em processo, que realizo numa escola pública. Sua constituição deve seu primeiro movimento às manifestações de desconforto e homofobia com relação a um grupo específico de três estudantes gays na comunidade escolar na qual atuo como professora. Percebo que a presença desse grupo desacomoda o cotidiano escolar e desenvolvo minha argumentação com base no potencial desestabilizador desses sujeitos, na intenção de pensar o impensável no currículo escolar. Esse trabalho parte da visibilidade de uma identidade sexual que foge à norma heterossexual e desafia a tendência normalizadora e homogeneizadora da educação. A maneira como esse grupo gay se posiciona e constrói seus corpos cruza as fronteiras do masculino/feminino, desnaturalizando as identidades sexuais e de gênero que se baseiam em características biológicas e se apresentando como diferença que escapa às classificações binárias. Na construção da pesquisa utilizo como referência o pensamento de Michel Foucault, especialmente com relação à construção histórica e discursiva de conceitos como sexualidade, identidade, diferença e normalidade que têm servido para criação e manutenção de padrões de conduta. Ao levar a problematização desses conceitos para o contexto escolar, considero produtiva a teorização queer para pensar a possibilidade de uma educação não heteronormativa, produtora de diferenças, que desconstrua identidades ao invés de tentar cristalizá-las.

  6. Response of saliva Na/K ratio to changing Na supply of lactating cows under tropical conditions

    NARCIS (Netherlands)

    Thiangtum, Wandee; Schonewille, J Thomas; Verstegen, Martin Wa; Arsawakulsudhi, Supot; Rukkwamsuk, Theera; Hendriks, Wouter H

    BACKGROUND: Factorial determination of the sodium (Na) requirement of heat-stressed lactating cows is hindered by accurate estimates of the Na losses through sweat. Direct studies, therefore, may be needed requiring information on the time course of healthy animals to become Na depleted and the

  7. Response of saliva Na/K ratio to changing Na supply of lactating cows under tropical conditions

    NARCIS (Netherlands)

    Thiangtum, Wandee; Schonewille, Thomas J.; Verstegen, Martin W.A.; Arsawakulsudhi, Supot; Rukkwamsuk, Theera; Hendriks, Wouter H.

    2017-01-01

    BACKGROUND: Factorial determination of the sodium (Na) requirement of heat-stressed lactating cows is hindered by accurate estimates of the Na losses through sweat. Direct studies, therefore, may be needed requiring information on the time course of healthy animals to become Na depleted and the

  8. Polarization and collision velocity dependence of associative ionization in cold Na (3p)-Na(3p) collisions

    NARCIS (Netherlands)

    Meijer, H.A.J.

    1990-01-01

    We studied the polarization dependence of the associative ionization (AI) process Na(3p) + Na(3p) → Na2+ at collision velocities between 100 and 700 m/s (5 and 200 K), using linearly and circularly polarized light for the excitation. We found that the polarization dependence varies strongly in the

  9. Irreversible block of cardiac mutant Na+ channels by batrachotoxin.

    Science.gov (United States)

    Wang, Sho-Ya; Tikhonov, Denis B; Mitchell, Jane; Zhorov, Boris S; Wang, Ging Kuo

    2007-01-01

    Batrachotoxin (BTX) not only keeps the voltage-gated Na(+) channel open persistently but also reduces its single-channel conductance. Although a BTX receptor has been delimited within the inner cavity of Na(+) channels, how Na(+) ions flow through the BTX-bound permeation pathway remains unclear. In this report we tested a hypothesis that Na(+) ions traverse a narrow gap between bound BTX and residue N927 at D2S6 of cardiac hNa(v)1.5 Na(+) channels. We found that BTX at 5 microM indeed elicited a strong block of hNa(v)1.5-N927K currents (approximately 70%) after 1000 repetitive pulses (+50 mV/20 ms at 2 Hz) without any effects on Na(+) channel gating. Once occurred, this unique use-dependent block of hNa(v)1.5-N927K Na(+) channels recovered little at holding potential (-140 mV), demonstrating that BTX block is irreversible under our experimental conditions. Such an irreversible effect likewise developed in fast inactivation-deficient hNa(v)1.5-N927K Na(+) channels albeit with a faster on-rate; approximately 90% of peak Na(+) currents were abolished by BTX after 200 repetitive pulses (+50 mV/20 ms). This use-dependent block of fast inactivation-deficient hNa(v)1.5-N927K Na(+) channels by BTX was duration dependent. The longer the pulse duration the larger the block developed. Among N927K/W/R/H/D/S/Q/G/E substitutions in fast inactivation-deficient hNa(v)1.5 Na(+) channels, only N927K/R Na(+) currents were highly sensitive to BTX block. We conclude that (a) BTX binds within the inner cavity and partly occludes the permeation pathway and (b) residue hNa(v)1.5-N927 is critical for ion permeation between bound BTX and D2S6, probably because the side-chain of N927 helps coordinate permeating Na(+) ions.

  10. MOBILNO POSLOVANJE NA PRIMERU UPORABE MICROSOFT DYNAMICS CRM

    OpenAIRE

    Duh, Tamara

    2016-01-01

    Hitro razvijajoči se svet nas spodbuja k hitremu reagiranju na novosti, ki se pojavljajo na trgu. Prav zaradi tega je danes zelo pomembno upravljati z mobilnimi napravami, da se lahko hitro in brez težav soočimo z morebitnimi težavami oz. zagatami. Prav iz tega razloga je mobilno poslovanje ena izmed inovativnih rešitev, ki ljudem omogoča seznanjenost z informacijami na vsakem koraku in omogoča hiter odziv na spremembe. Prav ta rešitev omogoča podjetjem, da so konkurenčna in hkrati lahko hitr...

  11. Na+ channel function, regulation, structure, trafficking and sequestration

    Science.gov (United States)

    Chen-Izu, Ye; Shaw, Robin M; Pitt, Geoffrey S; Yarov-Yarovoy, Vladimir; Sack, Jon T; Abriel, Hugues; Aldrich, Richard W; Belardinelli, Luiz; Cannell, Mark B; Catterall, William A; Chazin, Walter J; Chiamvimonvat, Nipavan; Deschenes, Isabelle; Grandi, Eleonora; Hund, Thomas J; Izu, Leighton T; Maier, Lars S; Maltsev, Victor A; Marionneau, Celine; Mohler, Peter J; Rajamani, Sridharan; Rasmusson, Randall L; Sobie, Eric A; Clancy, Colleen E; Bers, Donald M

    2015-01-01

    This paper is the second of a series of three reviews published in this issue resulting from the University of California Davis Cardiovascular Symposium 2014: Systems approach to understanding cardiac excitation–contraction coupling and arrhythmias: Na+ channel and Na+ transport. The goal of the symposium was to bring together experts in the field to discuss points of consensus and controversy on the topic of sodium in the heart. The present review focuses on Na+ channel function and regulation, Na+ channel structure and function, and Na+ channel trafficking, sequestration and complexing. PMID:25772290

  12. Usando a antimatéria na medicina moderna

    OpenAIRE

    Machado,A.C.B.; Pleitez,V.; Tijero,M.C.

    2006-01-01

    Neste artigo, fazemos uma breve exposição de como um dos conceitos fundamentais da física moderna, a existência de antimatéria, tem aplicação na medicina, na chamada tomografia por emissão de pósitrons (PET na sigla em inglês). Ela consiste na produção de imagens tomográficas digitais do organismo que são obtidas pela detecção da radiação produzida na aniquilação do pósitron com o elétron.

  13. Novel regulation of cardiac Na pump via phospholemman.

    Science.gov (United States)

    Pavlovic, Davor; Fuller, William; Shattock, Michael J

    2013-08-01

    As the only quantitatively significant Na efflux pathway from cardiac cells, the Na/K ATPase (Na pump) is the primary regulator of intracellular Na. The transmembrane Na gradient it establishes is essential for normal electrical excitability, numerous coupled-transport processes and, as the driving force for Na/Ca exchange, thus setting cardiac Ca load and contractility. As Na influx varies with electrical excitation, heart rate and pathology, the dynamic regulation of Na efflux is essential. It is now widely recognized that phospholemman, a 72 amino acid accessory protein which forms part of the Na pump complex, is the key nexus linking cellular signaling to pump regulation. Phospholemman is the target of a variety of post-translational modifications (including phosphorylation, palmitoylation and glutathionation) and these can dynamically alter the activity of the Na pump. This review summarizes our current understanding of the multiple regulatory mechanisms that converge on phospholemman and govern NA pump activity in the heart. The corrected Fig. 4 is reproduced below. The publisher would like to apologize for any inconvenience caused. [corrected]. Copyright © 2013. Published by Elsevier Ltd.

  14. Synthesis of Na-A and/or Na-X zeolite/porous carbon composites from carbonized rice husk

    International Nuclear Information System (INIS)

    Katsuki, Hiroaki; Komarneni, Sridhar

    2009-01-01

    Na-A and/or Na-X zeolite/porous carbon composites were prepared under hydrothermal conditions by NaOH dissolution of silica first from carbonized rice husk followed by addition of NaAlO 2 and in situ crystallization of zeolites i.e., using a two-step process. When a one-step process was used, both Na-A and Na-X zeolites crystallized on the surface of carbon. Na-A or Na-X zeolite crystals were prepared on the porous carbonized rice husk at 90 deg. C for 2-6 h by changing the SiO 2 /Al 2 O 3 , H 2 O/Na 2 O and Na 2 O/SiO 2 molar ratios of precursors in the two-step process. The surface area and NH 4 + -cation exchange capacity (CEC) of Na-A zeolite/porous carbon were found to be 171 m 2 /g and 506 meq/100 g, respectively, while those of Na-X zeolite/porous carbon composites were 676 m 2 /g and 317 meq/100 g, respectively. Na-A and Na-X zeolites are well-known microporous and hydrophilic materials while carbonized rice husk was found to be mesoporous (pores of ∼3.9 nm) and hydrophobic. These hybrid microporous-mesoporous and hydrophilic-hydrophobic composites are expected to be useful for decontamination of metal cations as well as organic contaminants simultaneously. - Graphical Abstract: Novel Na-X zeolite/porous carbon composite.

  15. Synthesis of zeolites Na-A and Na-X from tablet compressed and calcinated coal fly ash

    Science.gov (United States)

    Hu, Tao; Gao, Wenyan; Liu, Xin; Zhang, Yifu; Meng, Changgong

    2017-10-01

    Zeolites Na-A and Na-X are important synthetic zeolites widely used for separation and adsorption in industry. It is of great significance to develop energy-efficient routines that can synthesize zeolites Na-A and Na-X from low-cost raw materials. Coal fly ash (CFA) is the major residue from the combustion of coal and biomass containing more than 85% SiO2 and Al2O3, which can readily replace the conventionally used sodium silicate and aluminate for zeolite synthesis. We used Na2CO3 to replace the expensive NaOH used for the calcination of CFA and showed that tablet compression can enhance the contact with Na2CO3 for the activation of CFA through calcination for the synthesis of zeolites Na-A and Na-X under mild conditions. We optimized the control variables for zeolite synthesis and showed that phase-pure zeolite Na-A can be synthesized with CFA at reactant molar ratio, hydrothermal reaction temperature and reaction time of 1.3Na2O: 0.6Al2O3: 1SiO2: 38H2O at 80°C for 6 h, respectively, while phase-pure zeolite Na-X can be synthesized at 2.2Na2O: 0.2Al2O3: 1SiO2: 88H2O at 100°C for 8 h, respectively. The composition, morphology, specific surface area, vibration spectrum and thermogravimetry of synthesized Na-A and Na-X were further characterized.

  16. Identidade, nação e território na escrita dos intelectuais Mapuches

    Directory of Open Access Journals (Sweden)

    Claudia Zapata Silva

    2007-12-01

    Full Text Available Este artigo tem por objetivo dar conta de um novo sujeito indígena, surgido na segunda metade do século XX: o intelectual indígena contemporâneo, formado em instituições de educação superior e que constrói discursos e representações a partir de uma disciplina do conhecimento (História, Sociologia, Literatura, Antropologia, entre outras. Abordarse- á o caso particular dos intelectuais mapuches na década de noventa, a partir de uma perspectiva de análise que os considera como autores e como atores de contornos próprios no interior do que, na atualidade, se conhece como Movimento Mapuche.

  17. Erythrocyte Na+/K+ ATPase activity measured with sup 23 Na NMR

    Energy Technology Data Exchange (ETDEWEB)

    Ouwerkerk, R.; van Echteld, C.J.; Staal, G.E.; Rijksen, G. (University Hospital, Utrecht (Netherland))

    1989-11-01

    A {sup 23}Na NMR assay for measurement of erythrocyte Na+/K+ ATPase activity is presented. Using the nonpermeant shift reagent dysprosium tripolyphosphate the signals of intra- and extracellular sodium are separated, enabling measurement of sodium fluxes nondestructively, without the need to physically separate the cells from their environment. By increasing membrane permeability with nystatin we have shown that the assay allows the detection of differences in membrane permeability. With low doses of nystatin the ouabain-sensitive sodium flux increased more than twofold. With high doses of nystatin the Na+/K+ pump could not prevent an almost total equilibration of intra- and extracellular sodium. All sodium that entered the cells remained NMR visible, proving that sodium influx can be measured quantitatively. {sup 31}P NMR spectra taken before and after the assay revealed a slight acidification of the cells and no significant change in ATP concentration. No evidence of Dy3+ entering the cell was observed.

  18. Benefícios da cafeína na terapêutica

    OpenAIRE

    Ribeiro, Célia Pereira

    2013-01-01

    Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz A cafeína é uma substância amplamente consumida, principalmente pelas suas propriedades estimulantes. Mas é também utilizada a nível terapêutico, e são cada vez mais os estudos que procuram aprofundar e conhecer novas aplicações terapêuticas da cafeína. Existe uma extensa literatura acerca do citrato de cafeína para o tratamento da apneia de recém-nascidos prematuros, e os estudos indicam q...

  19. Mehanička svojstva i mikrostruktura vakuum plazma naprskane Cr3C2 - 25(Ni20Cr prevlake / Mechanical properties and microstructure of vacuum plasma sprayed Cr3C2 – 25(Ni20Cr coatings / Механические свойства и микроструктура покрытия Cr3C2 - 25(Ni20Cr нанесенного методом вакуумного плазменного напыления

    Directory of Open Access Journals (Sweden)

    Mihailo R. Mrdak

    2015-04-01

    Full Text Available U radu je analizirana vakuum plazma sprej prevlaka VPS – Cr3C2 - 25(Ni20Cr. Upotrebljen je komercijalni prah oznake Sulzer Metco Woka 7205. Prah je deponovan sa plazma pištoljem F4 na odstojanju substrata od 340 mm. Glavni cilj rada bio je da se na smanjenom pritisku inertnog gasa Ar eliminiše razgradnja primarnog karbida Cr3C2 u karbid Cr23C6 koji bitno umanjuje mikrotvrdoću i mehaničke karakteristike prevlake. Prevlaka je deponovana debljine od 100 do 120 µm na čeličnom substratu. Mikrotvrdoća prevlake ispitana je metodom HV0.3. Vrednosti mikrotvrdoće bile su u rasponu od 1248 do 1342 HV0.3. Čvrstoća spoja prevlake ispitana je metodom na zatezanje. Utvrđeno je da čvrstoća spoja između substrata i prevlake ima vrednost 89 MPa. Mikrostruktura prevlake ispitana je tehnikom svetlosne mikroskopije. Struktura prevlake sastoji se od osnove NiCr legure sa dominantnom primarnom karbidnom fazom Cr3C2. Pored Cr3C2 faze prisutna je i faza Cr7C3. Nagrizanje prevlake urađeno je reagensom 1HNO3: 4HCl: 4H2O koji prvenstveno rastvara Ni da bi se videla raspodela karbidne faze u prevlaci. Nagrizanjem prevlake reagensom utvrđeno je da je u slojevima prevlake u velikom udelu prisutna primarna nerazgrađena karbidna faza Cr3C2 koja prevlaci daje visoke vrednosti mikrotvrdoće. / This paper analyzes vacuum plasma spray VPS - Cr3C2 - 25(Ni20Cr coatings. Commercial powder marked Sulzer Metco Woka 7205 is used. The powder is deposited with a plasma gun F4 at a distance of 340 mm from the substrate. The main objective of the study was to eliminate, at the reduced pressure of inert gas Ar, the degradation of primary Cr3C2 carbide into Cr23C6 carbide which significantly reduces the microhardness and mechanical properties of the coating. The coating is deposited with a thickness of 100 - 120 µm on a steel substrate. The microhardness of the coating was tested by HV0.3. The microhardness values were in the range of 1248 - 1342 HV0.3. The bond strength

  20. Na+-K+ pump in chronic renal failure

    International Nuclear Information System (INIS)

    Deepak, K.; Kahn, T.

    1987-01-01

    This review summarizes the evidence for the defect in Na + -K + pump in chronic renal failure, considers the role of various factors in causing this defect, and discusses the clinical implications thereof. Intracellular Na is elevated in erythrocytes, leukocytes, and muscle cells from some patients with chronic renal failure (CRF). Recent evidence suggest that this elevation of cell Na may be, in large part, a consequence of decreased number of Na + -K + pump units per cell. Maintenance dialysis over a period of weeks ameliorates the defect in intracellular Na + , and this improvement is contemporaneous with an increase in the number of Na + -K + pump sites per cell. In erythrocytes with normal cell Na + , acute hemodialysis increases the rate of 22 Na + and 42 K + transport. Many factors such as the presence of retained toxic metabolite or circulating inhibitor in the uremic plasma, or biochemical changes produced by acute hemodialysis, may explain this finding. In cells with high cell Na + , the pump-mediated 42 K + transport is normalized at the expense of a raised cell Na + . The decreased muscle membrane potential in uremic subjects has been attributed to a decreased activity of Na + -K + pump. The authors discuss the role of hormonal abnormalities and circulating inhibitors, which may cause an acute inhibition of the pump and of other factors such as K + depletion, which may cause more chronic alterations. The implications of alteration of Na + and K + pump transport and raised cell Na + on other non-pump-mediated transport pathways are discussed. Raised cell Na + may be a marker for the adequacy of maintenance dialysis in patients with end-stage renal failure

  1. Study of π0 Dalitz decays in the NA62 and NA48/2 experiments

    Science.gov (United States)

    Maurice, E.; Ambrosino, F.; Antonelli, A.; Anzivino, G.; Arcidiacono, R.; Baldini, W.; Balev, S.; Bifani, S.; Biino, C.; Bizzeti, A.; Bloch-Devaux, B.; Bolotov, V.; Bucci, F.; Ceccucci, A.; Cenci, P.; Cerri, C.; Collazuol, G.; Costantini, F.; Cotta Ramusino, A.; Coward, D.; D'Agostini, G.; Dalpiaz, P.; Danielsson, H.; Dellacasa, G.; Di Filippo, D.; DiLella, L.; Doble, N.; Duk, V.; Engelfried, J.; Eppard, K.; Falaleev, V.; Fantechi, R.; Fiorini, M.; Frabetti, P. L.; Fucci, A.; Gallorini, S.; Gatignon, L.; Gersabeck, E.; Gianoli, A.; Giudici, S.; Goudzovski, E.; Goy Lopez, S.; Gushchin, E.; Hallgren, B.; Hita-Hochgesand, M.; Iacopini, E.; Imbergamo, E.; Kekelidze, V.; Kleinknecht, K.; Kozhuharov, V.; Kurshetsov, V.; Lamanna, G.; Lazzeroni, C.; Lenti, M.; Leonardi, E.; Litov, L.; Madigozhin, D.; Maier, A.; Mannelli, I.; Marchetto, F.; Massarotti, P.; Misheva, M.; Molokanova, N.; Moulson, M.; Movchan, S.; Napolitano, M.; Norton, A.; Numao, T.; Obraztsov, V.; Palladino, V.; Pepe, M.; Peters, A.; Petrucci, F.; Peyaud, B.; Piandani, R.; Piccini, M.; Pierazzini, G.; Popov, I.; Potrebenikov, Yu.; Raggi, M.; Renk, B.; Retière, F.; Riedler, P.; Romano, A.; Rubin, P.; Ruggiero, G.; Salamon, A.; Saracino, G.; Savrié, M.; Semenov, V.; Sergi, A.; Serra, M.; Shkarovskiy, S.; Sozzi, M.; Spadaro, T.; Valente, P.; Veltri, M.; Venditti, S.; Wahl, H.; Wanke, R.; Winhart, A.; Winston, R.; Yushchenko, O.; Zinchenko, A.; NA62 Collaboration; NA48/2 Collaboration

    2017-01-01

    The NA62 experiment at CERN collected a large sample of charged kaon decays with a highly efficient trigger for decays into electrons in 2007. The kaon beam represents a source of tagged neutral pion decays in vacuum. A measurement of the electromagnetic transition form factor slope of the neutral pion in the time-like region from ∼1 million fully reconstructed π0 Dalitz decay is presented. The limits on dark photon production in π0 decays from the earlier kaon experiment at CERN, NA48/2, are also reported.

  2. Fitoterápicos na odontologia: estudo etnobotânico na cidade de Manaus

    Directory of Open Access Journals (Sweden)

    S. S. Evangelista

    2013-01-01

    Full Text Available O reconhecimento oficial da fitoterapia na odontologia no Brasil veio acompanhado de diversas lacunas na pesquisa científica e na utilização de plantas medicinais, especificamente para espécies vegetais com aplicação nas doenças da cavidade oral. O estado do Amazonas, especificamente a cidade de Manaus, não possui um diagnóstico da aplicabilidade de plantas medicinais nos serviços de atenção Odontológica. Esse estudo propôs realizar um estudo do tipo quali-quantitativo, descritivo e exploratório visando o levantamento da comercialização de plantas medicinais e o estudo etnobotânico para identificação das principais plantas medicinais indicadas e utilizadas nas patologias orais nos atendimentos odontológicos ambulatoriais na cidade de Manaus. Foram entrevistados 197 usuários do serviço odontológico, 150 Cirurgiões-Dentistas, e 47 comerciantes credenciados na prefeitura Municipal de Manaus. A amostragem foi realizada por acessibilidade ou conveniência para os Cirurgiões-Dentistas, enquanto os usuários foram selecionados através de amostragem aleatória simples, e os comerciantes de plantas medicinais foram entrevistados em sua totalidade. Os resultados demonstraram a existência de comercialização de plantas medicinais para patologias orais, destacando-se as seguintes espécies: Pedra ume cãa (Aulomyrcia sphareocarpa, Crajiru (Arrabidae chica, além da planta, sem identificação botânica, conhecida popularmente como Sara tudo. Entre os Cirurgiões-Dentistas e entre os pacientes, apenas 8% e 7,61%, respectivamente, utilizaram plantas medicinais para alterações patológicas orais. Os autores concluíram que as plantas medicinais comercializadas na cidade de Manaus são utilizadas de maneira empírica e que, apesar da Política Nacional de Práticas Integrativas e Complementares (PNPIC, novas políticas públicas de saúde devem inserir plantas medicinais e fitoterápicos de uso oral na rede pública de saúde na

  3. OGLAŠEVANJE NA SOCIALNEM OMREŽJU FACEBOOK, NA PRIMERU SPLETICNA.SI

    OpenAIRE

    Reisman, Nina

    2011-01-01

    Internet je od svojega razvoja dolgo časa obstajal kot prostor za enostransko komunikacijo. Isto se je dogajalo na televiziji, radiu in časopisih, kjer je javnost sprejemala informacije, ki jih je nekdo pripravil. Tradicionalni mediji so hitro doumeli, da takšna vrsta komunikacije ni naravna in ne predstavlja najboljšega ohranjanja gledalcev in poslušalcev. Začela se je uporabljati dvosmerna komunikacija. Trenutno v svetu najbolje poznan primer dvosmerne komunikacije je socialno omrežje F...

  4. Načrtovanje izkoriščanja hidroenergije na primeru reke Mure

    OpenAIRE

    Madjar, Klaudija

    2016-01-01

    Reka Mura lahko kot neizkoriščen hidro potencial pripomore k zvišanju deleža energije iz obnovljivih virov. V diplomski nalogi je opisano izkoriščanje energije vode za pridobivanje električne energije, predstavljene pa so tudi obstoječe hidroelektrarne v Sloveniji. Nadalje so opisane hidrološke značilnosti reke Mure in ekosistemi ob njej. Načrtovane hidroelektrarne na reki Muri predstavljajo precejšen poseg v določeno območje, zato ga je pred realizacijo potrebno dobro proučiti. Izgradnja hid...

  5. Transtorno afetivo bipolar na infância e na adolescência

    OpenAIRE

    Fu-I,Lee

    2004-01-01

    Os conhecimentos sobre transtorno afetivo bipolar com início na infância e na adolescência têm avançado muito nos últimos 15 anos. Atualmente, os esforços estão dirigidos para investigar o quadro clínico, para o desenvolvimento de instrumentos que auxiliam diagnóstico precoce e investigações de melhores formas de tratamentos de crianças e adolescentes portadores do transtorno. O presente texto tem objetivo de apresentar as principais características clínicas do transtorno em crianças e adoles...

  6. NaI(Tl) response functions

    Energy Technology Data Exchange (ETDEWEB)

    Vega C, H. R.; Ortiz R, J. M. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas, Zac. (Mexico); Benites R, J. L. [Centro Estatal de Cancerologia de Nayarit, Calz. de la Cruz 118 Sur, Tepic, Nayarit (Mexico); De Leon M, H. A., E-mail: fermineutron@yahoo.com.mx [Instituto Tecnologico de Aguascalientes, Av. Adolfo Lopez Mateos 1801 Ote., 20155 Aguascalientes, Ags. (Mexico)

    2015-09-15

    The response functions of a NaI(Tl) detector have been estimated using Monte Carlo methods. Response functions were calculated for monoenergetic photon sources (0.05 to 3 MeV). Responses were calculated for point-like sources and for sources distributed in Portland cement cylinders. The responses were used to calculate the efficiency functions in term of photon energy. Commonly, sources used for calibration are point-like, and eventually sources to be measured have different features. In order to use the calibrated sources corrections due to solid angle, self-absorption and scattering, must be carried out. However, some of these corrections are not easy to perform. In this work, the calculated responses were used to estimate the detector efficiency of point-like sources, and sources distributed in Portland type cement. Samples of Portland paste were prepared and were exposed to photoneutrons produced by a 15 MV linac. Some of the elements in the cement were activated producing γ-emitting radionuclides that were measured with a NaI(Tl) gamma-ray spectrometer, that was calibrated with point-like sources. In order to determine the specific activity in the induced radioisotopes calculated efficiencies were used to make corrections due to the differences between the solid angle, photon absorption and photon scattering in the point-like calibration sources and the sources distributed in cement. During the interaction between photoneutrons and the cement samples three radioisotopes were induced: {sup 56}Mn, {sup 24}Na, and {sup 28}Al. (Author)

  7. Linguagens na TV Languages on tv

    Directory of Open Access Journals (Sweden)

    Glaucia Guimarães

    2008-06-01

    Full Text Available Este artigo aborda questões relativas às estratégias discursivas utilizadas na produção dos textos televisivos. Com base na Análise Crítica de Discurso (ACD, nos termos em que é formulada por Norman Fairclough, o trabalho analisa os modos pelos quais as linguagens (incluindo materiais semióticos diversos são articuladas na/pela TV, sistematiza as relações entre a articulação de linguagens e a produção de efeitos de sentido, bem como os modos de sua inscrição nas tendências discursivas contemporâneas, a saber: democratização, tecnologização e comodificação. A partir das relações entre as práticas de linguagem e as tendências destacadas, o artigo tece considerações sobre as condições de produção de leituras críticas dos textos multimidiáticos, nas suas múltiplas dimensões: dos contextos e mecanismos da produção textual à pluralidade constitutiva de sua recepção.This paper deals with issues related to discursive strategies in the production of TV texts. Based on Critical Discourse Analysis (CDA, as formulated by Norman Fairclough, it analyzes the ways languages (including several semiotic materials are articulated in order to produce a range of wanted meaning effects, as well as the ways they are inscribed in the contemporary discursive trends discussed by the author, namely: democratization, technologization and commodification. Departing from the analysis of language practices and the discursive trends underlined, the paper aims at clarifying the multiple dimensions of multimedia conditions of production, focusing on both the context and the mechanisms and the diverse reception (reading possibilities.

  8. Na(+),K (+)-ATPase as a docking station: protein-protein complexes of the Na(+),K (+)-ATPase.

    Science.gov (United States)

    Reinhard, Linda; Tidow, Henning; Clausen, Michael J; Nissen, Poul

    2013-01-01

    The Na(+),K(+)-ATPase, or sodium pump, is well known for its role in ion transport across the plasma membrane of animal cells. It carries out the transport of Na(+) ions out of the cell and of K(+) ions into the cell and thus maintains electrolyte and fluid balance. In addition to the fundamental ion-pumping function of the Na(+),K(+)-ATPase, recent work has suggested additional roles for Na(+),K(+)-ATPase in signal transduction and biomembrane structure. Several signaling pathways have been found to involve Na(+),K(+)-ATPase, which serves as a docking station for a fast-growing number of protein interaction partners. In this review, we focus on Na(+),K(+)-ATPase as a signal transducer, but also briefly discuss other Na(+),K(+)-ATPase protein-protein interactions, providing a comprehensive overview of the diverse signaling functions ascribed to this well-known enzyme.

  9. Importance of Residues Outside the Cation Binding Pocket for Na+ and K+ Binding to the Na+/K+-ATPase

    DEFF Research Database (Denmark)

    Christiansen, Line; Toustrup-Jensen, Mads Schak; Einholm, Anja P.

    Mutagenesis studies have identified several oxygen-containing residues in the transmembrane region which are important for the coordination of Na+ and/or K+. These were later confirmed by the high-resolution crystal structures of the Na+/K+-ATPase with bound Na+ or K+. However, more information...... is needed to reveal the translocation pathway through the Na+/K+-ATPase. Mutagenesis studies have shown that several other transmembrane residues located outside the cation binding pocket, including Phe785 and Phe788, affect the ion binding properties of the Na+/K+-ATPase (1,2). It is well...... not significantly affect the Na+ binding properties of the Na+/K+-ATPase. 1. Vilsen, B. (1999) Biochemistry 38, 11389 2. Rodacker, V. et al (2006) JBC 281, 18539 3. Laursen M et al. (2013) PNAS 110, 10958...

  10. Effect of growth in lithium on ouabain binding, Na-K-ATPase and Na and K transport in hela cells.

    Science.gov (United States)

    Boardman, L J; Hume, S P; Lamb, J F; Polson, J

    1975-01-01

    1. HeLa cells were grown for 24 hr in growth medium in which part of the Na was replaced with Li. Ion contents, cell volumes and numbers, Na-K-ATPase and specific ouabain binding were measured. In some experiments the Na efflux and net Na transport was also measured. 2. Growth in Li caused a rise in the specific ouabain binding and membrane Na-K-ATPase of these cells. The Li concentrations in the cells necessary to produce this effect ranged up to 50 mM. 3. It is suggested that Li, like Na, acts on the genetic material of the cells to cause the production of more Na pumps within the membrane. PMID:124350

  11. The NA48 liquid krypton prototype calorimeter

    Energy Technology Data Exchange (ETDEWEB)

    Barr, G.D.; Buchholz, P.; Carosi, R.; Coward, D.; Cundy, D.; Doble, N.; Gatignon, L.; Gonidec, A.; Hallgren, B.; Kesseler, G.; Lacourt, A.; Laverriere, G.; Linser, G.; Mast, M.; Schilly, P.; Schinzel, D.; Seidl, W.; Taureg, H.; Wahl, H.; Wicht, P. (CERN, Geneva (Switzerland)); Bertanza, L.; Bigi, A.; Calafiura, P.; Casali, R.; Cerri, C.; Fantechi, R.; Gennaro, G.; Gorini, B.; Mannelli, I.; Marzulli, V.; Pierazzini, G.; Schiuma, D.; Sergiampietri, F. (INFN, Pisa (Italy) Scuola Normale, Pisa (Italy) Univ. Pisa (Italy)); Bederede, D.; Debeer, M.; Debu, P.; Peyaud, B. (CE-Saclay-DAPNIA, 91 - Gif-sur-Yvette (France)); Kreutz, A. (Univ. Gesamthochschule Siegen (Germany)); Griesmayer, E.; Markytan, M.; Neuhofer, G.; Pernicka, M.; Taurok, A.; Viehhauser, G.; Wulz, C.E. (Oesterreichische Akademie der Wissenschaften, Inst. fuer Hochenergiephysik, Vienna (Austria)); Cagliari-Cambridge-CERN-Dubna-Edingburgh-Ferrara-Mainz-Perugia-Pisa-Saclay-Siegen-Torino-Vienna Collaboration

    1992-12-01

    The NA48 experiment for a precision measurement of the CP violation parameter element of'/element of in K[sup 0][yields]2[pi] decays will require a fast electromagnetic calorimeter with excellent energy and time resolution. A quasi homogeneous calorimeter using liquid krypton and a fast readout with 40 MHz FADCs is proposed. A prototype with 400 kg of liquid krypton was built and tested in an electron beam. Results for the energy, space and time resolution of this prototype are given. (orig.).

  12. Holistična obravnava motenj hranjenja

    OpenAIRE

    Arzenšek, Pia

    2017-01-01

    Izhodišča: Stres, nepravičnost, nespoštljivost, mediji, kot socialni, ter biološko-genetski, družinski in psihološki dejavniki tveganja v kombinacijah vplivajo na razvoj različnih motenj, bolezni, tudi motenj hranjenja (MH). Najpogostejše med njimi so anorexia nervosa, bulimija nervosa in kompulzivno prenajedanje, kot duševne motnje po mednarodni klasifikaciji. V novejšem času se pojavljajo nove oblike MH (ortoreksija, bigoreksija…). O MH govorimo kadar hrana postane osrednja tema posamezniko...

  13. O estresse na atividade gerencial do enfermeiro

    OpenAIRE

    Lautert Liana; Chaves Enaura H. B.; Moura Gisela M. S. S. de

    1999-01-01

    O trabalho do enfermeiro, principalmente no âmbito hospitalar, está, conforme diversos estudos, entre os que mais geram estresse em seus profissionais. Dessa forma, o objetivo desta investigação foi identificar as fontes geradoras de estresse na atividade gerencial do enfermeiro que trabalha no hospital e as principais alterações que o estresse pode acarretar sobre a saúde desse profissional. Trata-se de uma pesquisa quantitativa com uma amostra de 207 enfermeiros, realizada em 1996 em um hos...

  14. Results on leptonic probes from NA50

    CERN Document Server

    Alessandro, B; Arnaldi, R; Atayan, M; Baglin, C; Baldit, A; Bedjidian, Marc; Beolè, S; Boldea, V; Bordalo, P; Borenstein, S R; Borges, G; Bussière, A; Capelli, L; Castanier, C; Castor, J I; Chaurand, B; Cheynis, B; Chiavassa, E; Cicalò, C; Claudino, T; Comets, M P; Constantinescu, S; Cortese, P; Cruz, J; De Falco, A; De Marco, N; Dellacasa, G; Devaux, A; Dita, S; Drapier, O; Espagnon, B; Fargeix, J; Force, P; Gallio, M; Gavrilov, Yu K; Gerschel, C; Giubellino, P; Golubeva, M B; Gonin, M; Grigorian, A A; Grigorian, S; Grossiord, J Y; Guber, F F; Guichard, A; Gulkanian, H R; Hakobyan, R S; Haroutunian, R; Idzik, M; Jouan, D; Karavitcheva, T L; Kluberg, L; Kurepin, A B; Le Bornec, Y; Lourenço, C; Macciotta, P; MacCormick, M; Marzari-Chiesa, A; Masera, M; Masoni, A; Monteno, M; Musso, A; Petiau, P; Piccotti, A; Pizzi, J R; Prado da Silva, W L; Prino, F; Puddu, G; Quintans, C; Ramello, L; Ramos, S; Rato-Mendes, P; Riccati, L; Romana, A; Santos, H; Saturnini, P; Scalas, E; Scomparin, E; Serci, S; Shahoyan, R; Sigaudo, F; Sitta, M; Sonderegger, P; Tarrago, X; Topilskaya, N S; Usai, G L; Vercellin, Ermanno; Villatte, L; Willis, N; Wu, T

    2003-01-01

    The NA50 Collaboration has performed a new measurement of the J/ psi yield in Pb-Pb collisions at 158 GeV/nucleon in improved experimental conditions. Our preliminary analysis of the year 2000 data sample, while confirming the onset of anomalous suppression and the non saturation of the J/ psi /Drell-Yan cross-section ratio, shows that peripheral Pb-Pb interactions follow the normal nuclear absorption pattern, which has in turn been established more precisely thanks to high statistics p-A data. (11 refs).

  15. Processo de pintura na Preh Portugal

    OpenAIRE

    Pontes, José Luís Pereira

    2016-01-01

    Neste estágio trabalhei no departamento de Engenharia de Processo e Automatização. Os Engenheiros que trabalham nesse departamento têm diversas funções. Desde ser responsáveis por uma linha de montagem; responsável por todas as alterações de engenharia; responsável pela parte eletrónica; responsável pela parte de pintura; entre outras. Também auxiliei na criação e atualização de Standards dentro da organização. Inicialmente, estes Standards ou estavam em formato Excel com basta...

  16. Cerenkov counter for the experiment NA3

    CERN Multimedia

    1978-01-01

    The program of the NA3 experiment included the study of hadronic interactions with a large transverse momentum pT, thus the inclusion in the set-up of three gas threshold Cerenkov counters of large acceptance. The photo shows the downstream part of the second Cerenkov (located at the output of the magnet). The yellow membrane is a temporary protection for the optics (shown in photo 7810540X) to be taken away when fixing this part to the gas tank (entering the magnet and not shown). The photomultipliers all around are heavily shielded.

  17. Sexualidade, Espiritualidade e Conjugalidades na Wicca Brasileira

    OpenAIRE

    Cordovil, Daniela

    2017-01-01

    Resumo Este artigo propõe uma análise do papel da sexualidade nas práticas da Wicca, religião neopagã surgida na Inglaterra entre 1940 e 1950. Atualmente, a Wicca é um movimento mundial multifacetado, que segue inúmeras vertentes. Esta pesquisa investiga concepções e práticas ligadas à sexualidade presentes entre grupos que praticam a Wicca publicamente em diversas capitais do Brasil. Esses grupos estão organizados em tradições (grupos religiosos com viés iniciático) que comandam associações ...

  18. Qualidade de vida na epilepsia infantil

    OpenAIRE

    SOUZA ELISABETE ABIB PEDROSO DE

    1999-01-01

    A epilepsia é desordem crônica que ocorre principalmente na infância e adolescência. Tradicionalmente, o tratamento da epilepsia enfatiza aspectos neurológicos mais do que fatores psicológicos. A aten��ão voltada simplesmente para o controle das crises no contexto clínico pode não ser suficiente para entender a grande amplitude de problemas que afetam a qualidade de vida das crianças com epilepsia. Muitas das dificuldades psicossociais dos adultos com epilepsia desenvolvem-se a partir de comp...

  19. DEPRESSÃO E ENVELHECIMENTO NA CONTEMPORANEIDADE

    Directory of Open Access Journals (Sweden)

    Delia Catullo Goldfarb

    2010-02-01

    Full Text Available RESUMO: O presente texto reproduz os trabalhos apresentados em mesa redonda sobre depressão e envelhecimento na contemporaneidade no III Congresso Ibero-americano de Psicogerontologia, realizado em novembro de 2010 em São Paulo. Estes trabalhos são resultado de reflexões precedentes em um grupo de estudos e de discussão de casos clínicos composto por psicanalistas. A depressão é uma figura psicopatológica de presença maciça nos dias de hoje. Na velhice o acúmulo de perdas e a aproximação da morte podem produzir um estado de tristeza, fundo depressivo que caracteriza um momento de recolhimento em que ocorrem os processos de luto. Em alguns sujeitos o que se verifica é a instalação de um episódio depressivo que indica a paralisação destes processos elaborativos e a progressão de um esvaziamento do sentido para a vida, restando, neste contexto, apenas a espera pela morte. Neste trabalho serão discutidos aspectos que concernem a vivência destas duas modalidades de enfrentamento da entrada na velhice, levando-se em conta as maneiras como a cultura pode favorecer a ocorrência destes percursos distintos do envelhecer, e como ela os aloja atualmente em um movimento de desconsideração da subjetividade: desanimo da velhice ou problema neuroquímico? Serão apresentadas hipóteses para a produção da depressão como psicopatologia no envelhecimento e reflexões sobre observações clínicas que derivam destes quadros clínicos, tais como: a crise da percepção da entrada na velhice, o corpo hipocondríaco, a paralisia do tempo, a vivência do desamparo. Palavras-chave: depressão, envelhecimento, cultura, corpo, tempo

  20. O mito da autoestima na aprendizagem escolar

    OpenAIRE

    Franco, Adriana de Fátima

    2009-01-01

    Este artigo analisa, nos marcos da perspectiva sócio-histórica, a construção social da autoestima e suas relações com o fracasso escolar. Fundamentada nos pressupostos de Vigotski, nega a possibilidade da valoração que o sujeito faz de si estar atrelada a atributos naturalmente humanos e presentes desde o nascimento. A compreensão do ser humano é feita a partir de uma análise de homem enquanto ser concreto, social, histórico e cultural que constrói sua humanidade na interação com outros homen...

  1. O dano pessoal na sociedade de risco

    OpenAIRE

    Hofmeister, Maria Alice Costa

    2000-01-01

    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Jurídicas. Estudo do dano pessoal e sua indenização, sob a ótica do dano corporal. Equaciona-se a matéria a partir do homem na pós-modernidade. Conclui-se que urge repensar as normas à luz de uma interpretação constitucional para atender à função mais importante da responsabilidade hoje reconhecida: indenizar a vítima. A indenização deverá ser reorientada para priorizar as necessidades da vítima em concreto. ...

  2. O TRADICIONALISMO NA LINGUAGEM JURÍDICA

    OpenAIRE

    Eliane Simões Pereira Bulhões

    2009-01-01

    Este artigo tem como objetivo analisar alguns aspectos do discurso atual do Direito brasileiro. Apoiando-se em pressupostos teóricos do lingüista russo Mikhail Bakhtin (1895-1975), segundo os quais a linguagem é instância ideológica por excelência, presentes na obra Marxismo e filosofia da linguagem, procuramos avaliar a linguagem jurídica como expressão do componente ideológico. Para tanto utilizamos um modelo de petição jurídica colhido em um guia para advogados, o qual nos serve como corpu...

  3. O TRADICIONALISMO NA LINGUAGEM JURÍDICA

    Directory of Open Access Journals (Sweden)

    Eliane Simões Pereira Bulhões

    2009-02-01

    Full Text Available Este artigo tem como objetivo analisar alguns aspectos do discurso atual do Direito brasileiro. Apoiando-se em pressupostos teóricos do lingüista russo Mikhail Bakhtin (1895-1975, segundo os quais a linguagem é instância ideológica por excelência, presentes na obra Marxismo e filosofia da linguagem, procuramos avaliar a linguagem jurídica como expressão do componente ideológico. Para tanto utilizamos um modelo de petição jurídica colhido em um guia para advogados, o qual nos serve como corpus representativo da linguagem forense.

  4. [Effects of NaCl stress on the seedling growth and K(+)- and Na(+) -allocation of four leguminous tree species].

    Science.gov (United States)

    Mo, Hai-Bo; Yin, Yun-Long; Lu, Zhi-Guo; Wei, Xiu-Jun; Xu, Jian-Hua

    2011-05-01

    Taking the pot-cultured seedlings of four leguminous tree species (Albizia julibrissin, Robinia pseudoacacia, Sophora japonica, and Gleditsia sinensis) as test materials, this paper studied their growth indices, critical salt concentration (C50), and K+ and Na+ allocation under different levels of NaCl stress, aimed to understand the difference of test tree species in salt tolerance. NaCl stress inhibited the seedling growth of the tree species. Under NaCl stress, the dry matter accumulation decreased, while the root/shoot ratio increased, especially for A. julibrissin and G. sinensis. Quadratic regression analysis showed that the C50 of A. julibrissin, R. pseudoacacia, S. japonica, and G. sinensis was 3.0 per thousand, 5.0 per thousand, 4.5 per thousand, and 3.9 per thousand, respectively, i.e., the salt tolerance of the four tree species was in the order of R. pseudoacacia > S. japonica > G. sinensis > A. julibrissin. In the root, stem, and leaf of the four tree species seedlings, the Na+ content increased with the increase of NaCl stress, while the K+ content (except in the root of A. julibrissin) decreased after an initial increase, resulting in a larger difference in the K+/Na+ ratio in the organs. Under the same NaCl stress, the allocation of Na+ in different organs of the four tree species seedlings decreased in the order of root>stem>leaf, while that of K+ differed with tree species and NaCl stress, and leaf was the main storage organ for K+. The K+/Na+ ratio in different organs decreased in the sequence of leaf>stem>root. R. pseudoacacia under NaCl stress accumulated more K+ and less Na+ in stem and leaf, and had higher K+/Na+ ratio in all organs and higher dry mass, being assessed to be more salt-tolerant. In contrast, A. julibrissin under high NaCl stress accumulated more Na+ in stem and leaf, and had a lower K+/Na+ ratio in all organs and lower dry mass, being evaluated to be lesser salt-tolerant. The K+ accumulation in seedling stem and leaf and the Na

  5. Relationship between intracellular Na+ concentration and reduced Na+ affinity in Na+,K+-ATPase mutants causing neurological disease

    DEFF Research Database (Denmark)

    Toustrup-Jensen, Mads Schak; Einholm, Anja P.; Schack, Vivien

    was observed for the +28 mutation of α2 despite a high expression level. A significant rise of [Na+]i and reduction of [K+]i was detected in cells expressing mutants with reduced Na+ affinity and did not require a concomitant reduction of the maximal catalytic turnover rate or expression level. Moreover, two...

  6. Adsorbed or intercalated: Na on graphene/Ir(111)

    Science.gov (United States)

    Pervan, Petar; Lazić, Predrag

    2017-09-01

    Interaction of sodium with graphene (Gr) on Ir(111) was studied with the aim to resolve the issue of Na adsorption/intercalation kinetics. The system Na/Gr/Ir(111) was studied by means of angle-resolved photoemission spectroscopy, low-energy electron diffraction, and ab initio density functional theory (DFT) calculation. It has been found that at room temperature (RT) and low concentrations Na is dominantly adsorbed on graphene. At higher concentrations, an intercalation process sets in so that it is possible to observe the coexistence of these two states. Eventually, all Na atoms are found in the intercalated state as determined by exposure to oxygen. While adsorption of Na on graphene already intercalated by Na [Na/Gr/Na/Ir(111) system] at RT was not possible, we could observe Li adsorption through the increase of Dirac point binding energy. Li coadsorption strongly affects the binding energy of the iridium surface state as well. This finding was supported by DFT calculations of adsorption energy of Na and Li on bare and fully Na intercalated graphene.

  7. Advancement of technology towards developing Na-ion batteries

    Science.gov (United States)

    Jamesh, Mohammed Ibrahim; Prakash, A. S.

    2018-02-01

    The Na-ion-batteries are considered much attention for the next-generation power-sources due to the high abundance of Na resources that lower the cost and become the alternative for the state of the art Li-ion batteries in future. In this review, the recently reported potential cathode and anode candidates for Na-ion-batteries are identified in-light-of-their high-performance for the development of Na-ion-full-cells. Further, the recent-progress on the Na-ion full-cells including the strategies used to improve the high cycling-performance (stable even up-to 50000 cycles), operating voltage (even ≥ 3.7 V), capacity (>350 mAhg-1 even at 1000 mAg-1 (based-on-mass-of-the-anode)), and energy density (even up-to 400 Whkg-1) are reviewed. In addition, Na-ion-batteries with the electrodes containing reduced graphene oxide, and the recent developments on symmetric Na-ion-batteries are discussed. Further, this paper identifies the promising Na-ion-batteries including the strategies used to assemble full-cell using hard-carbon-anodes, Na3V2(PO4)3 cathodes, and other-electrode-materials. Then, comparison between aqueous and non-aqueous Na-ion-batteries in terms of voltage and energy density has been given. Later, various types of electrolytes used for Na-ion-batteries including aqueous, non-aqueous, ionic-liquids and solid-state electrolytes are discussed. Finally, commercial and technological-developments on Na-ion-batteries are provided. The scientific and engineering knowledge gained on Na-ion-batteries afford conceivable development for practical application in near future.

  8. Apical Na+ permeability of frog skin during serosal Cl- replacement.

    Science.gov (United States)

    Leibowich, S; DeLong, J; Civan, M M

    1988-05-01

    Gluconate substitution for serosal Cl- reduces the transepithelial short-circuit current (Isc) and depolarizes short-circuited frog skins. These effects could result either from inhibition of basolateral K+ conductance, or from two actions to inhibit both apical Na+ permeability (PapNa) and basolateral pump activity. We have addressed this question by studying whole-and split-thickness frog skins. Intracellular Na+ concentration (CcNa) and PapNa have been monitored by measuring the current-voltage relationship for apical Na+ entry. This analysis was conducted by applying trains of voltage pulses, with pulse durations of 16 to 32 msec. Estimates of PapNa and CcNa were not detectably dependent on pulse duration over the range 16 to 80 msec. Serosal Cl- replacement uniformly depolarized short-circuited tissues. The depolarization was associated with inhibition of Isc across each split skin, but only occasionally across the whole-thickness preparations. This difference may reflect the better ionic exchange between the bulk medium and the extracellular fluid in contact with the basolateral membranes, following removal of the underlying dermis in the split-skin preparations. PapNa was either unchanged or increased, and CcNa either unchanged or reduced after the anionic replacement. These data are incompatible with the concept that serosal Cl- replacement inhibits PapNa and Na,K-pump activity. Gluconate substitution likely reduces cell volume, triggering inhibition of the basolateral K+ channels, consistent with the data and conclusions of S.A. Lewis, A.G. Butt, M.J. Bowler, J.P. Leader and A.D.C. Macknight (J. Membrane Biol. 83:119-137, 1985) for toad bladder. The resulting depolarization reduces the electrical force favoring apical Na+ entry. The volume-conductance coupling serves to conserve volume by reducing K+ solute loss. Its molecular basis remains to be identified.

  9. Estudo comparativo entre ropivacaína a 0,5% e bupivacaína a 0,5% ambas hiperbáricas, na raquianestesia

    OpenAIRE

    Carvalho, Afonso Cláudio dos Reis e; Machado, Jean Abreu; Nociti, José Roberto

    2002-01-01

    JUSTIFICATIVA E OBJETIVOS - Estudos clínicos e experimentais já demonstraram a eficácia e a segurança da ropivacaína aplicada a estruturas nervosas por via subaracnóidea. Por outro lado, a potência da ropivacaína em raquianestesia é aproximadamente igual à metade da potência de bupivacaína, considerando-se soluções hiperbáricas. O objetivo deste estudo foi comparar as características do bloqueio subaracnóideo com ropivacaína ou bupivacaína hiperbáricas, em doses equipotentes. MÉTODO - Vinte p...

  10. Saturation effects in Na lidar temperature measurements

    International Nuclear Information System (INIS)

    von der Gathen, P.

    1991-01-01

    Na atoms residing in the 80-110 km altitude region can be used to probe the Doppler-broadened hyperfine structure (hfs) of their D 2 resonance by ground-bases lidar and hence to deduce atmospheric temperatures. In principle, two different methods may be employed: (1) wavelength scanning of the hfs with a narrow-band laser and signal detection with a broad-band receiver, and (2) use of a broad-band laser and wavelength scanning of the hfs with a narrow-band receiver. These two methods are affected in different ways by laser-induced saturation in the Na layer, the effect on the measurements of sodium densities and of atmospheric temperatures being quite different. Density measurements are affected by the absolute level of saturation. Temperature measurements, however, are affected by the difference in saturation at the scanned wavelengths. If, additionally, observed signal levels are taken into account, method 1 is more efficient than method 2 for both types of measurements at nighttime, whereas a modified method 2 surpasses method 1 for temperature measurements at daytime

  11. ESTUDO DO EMPODERAMENTO NA PERSPECTIVA DAS MULHERES

    Directory of Open Access Journals (Sweden)

    Karoline Brasil de Oliveira

    2015-12-01

    Full Text Available Este trabalho objetivou conhecer como as mulheres que ocupam cargos de liderança, utilizam o empoderamento no exercício profissional em uma instituição de ensino e tecnologia em Criciúma, Santa Catarina, Brasil. Na revisão da literatura foram contextualizados a mulher e sua inserção no mercado de trabalho, em busca de uma concepção de empoderamento e as dimensões do empoderamento da mulher no mercado de trabalho. A metodologia utilizada teve caráter descritivo e qualitativo. O instrumento de coleta de dados consistiu num roteiro com 16 questões que abordaram o bem-estar e sucesso profissional, o reconhecimento familiar, o processo de ascensão profissional e a participação das mulheres nos processos decisórios organizacionais. A pesquisa foi realizada com 10 mulheres que ocupavam cargos de chefia em diferentes setores da instituição em análise. Os resultados obtidos na pesquisa revelaram que as entrevistadas já demonstram expressões de empoderamento em seus cotidianos e a mulher se apresenta mais confiante e preparada para participar das tomadas de decisões em níveis hierárquicos maiores, além de interferir no próprio meio.

  12. Desafios na gestão escolar

    Directory of Open Access Journals (Sweden)

    Flávia Obino Corrêa Werle

    2015-09-01

    Full Text Available Este estudo discute a avaliação em larga escala da educação básica, os processos de regulação e debate processos de gestão realizados no interior da escola pública. Seu objetivo é compreender como a equipe diretiva de duas escolas da rede pública estadual de Porto Alegre, Brasil, se apropria dos resultados do Indíce de Desenvolvimento da Educação Básica (IDEB e como lida com eles na gestão escolar. A metodologia utilizada é de cunho qualitativo com coleta de dados através de um questionário estruturado. Apresenta os resultados do IDEB das duas escolas no período de 2009 e 2011. Na prática escolar a apropriação ocorre em três dimensões (pedagógica, administrativa e participativa e promove diálogos em diferentes níveis: com a hierarquia do sistema educacional, com a comunidade externa à escola e, internamente, com os professores e demais membros da comunidade escolar.

  13. Criptococose pulmonar: aspectos na tomografia computadorizada

    Directory of Open Access Journals (Sweden)

    Silva Ana Carina Gamboa da

    2003-01-01

    Full Text Available A criptococose pulmonar é uma doença causada pelo Criptococcus neoformans, um fungo unimórfico que possui distribuição mundial, existindo na mesma forma tanto no seu habitat natural quanto em animais e humanos. A doença possui apresentações clínica e patológica variáveis e pode manifestar-se tanto em pacientes com a imunidade normal como em imunocomprometidos, que representam a maioria dos casos. Neste trabalho são analisados os aspectos encontrados nas tomografias computadorizadas do tórax de 14 pacientes com criptococose pulmonar confirmada. Os achados mais freqüentes na tomografia do tórax foram as massas e os nódulos pulmonares. Outros aspectos observados foram as áreas de escavação, as consolidações, o espessamento do interstício peribroncovascular e o reticulado difuso. Massa pulmonar foi o achado isolado mais comum (64,2%, seguido dos nódulos isolados ou múltiplos (35,7%. Doença pulmonar difusa foi vista em apenas 14,2% dos casos. Os lobos superiores foram os mais comprometidos, sendo a doença mais comum nas regiões anteriores. A tomografia do tórax permitiu avaliar com precisão o grau de comprometimento do parênquima pulmonar.

  14. Vinhos, Turismo e Pluriatividade na Agricultura

    Directory of Open Access Journals (Sweden)

    Hernanda Tonini

    2013-06-01

    Full Text Available A gastronomia, além de ter importante relação com a economia, é uma forma expressiva da cultura dos indivíduos, desde o tipo de alimentos cultivados até a maneira de seu preparo e consumo. O presente artigo propõe-se a analisar a relação entre o enoturismo – centralizado na existência do vinho enquanto elemento gastronômico – e o fenômeno da pluriatividade na agricultura familiar, vista nos últimos anos como alternativa positiva para sua reprodução econômica e social. O fluxo turístico em regiões vitivinícolas gera novas oportunidades de trabalho e faz com que agricultores e suas famílias dividam a mão de obra agrícola, até então direcionada ao cultivo da uva e outros alimentos para subsistência, com atividades não agrícolas – como o artesanato, o acolhimento de visitantes em pousadas, a atuação em restaurantes, entre outras – como chance de subsistência. Este panorama transforma as realidades do mundo rural, alterando a relação do agricultor com a produção de alimentos e a forma como o mesmo os utiliza, além de reestruturar o ambiente sociocultural no seu entorno.  

  15. Brasileiros na fronteira com o Paraguai

    Directory of Open Access Journals (Sweden)

    Marcia Anita Sprandel

    2006-08-01

    Full Text Available O ARTIGO apresenta uma cartografia da situação social dos brasileiros e seus descendentes que vivem no Paraguai. Os distintos mapas (artigos, dissertações, teses e relatórios, com suas múltiplas perspectivas, permitem que se relativizem as narrativas midiáticas e a concepção da região como "lugar difícil". Ao discorrer sobre trabalhos de diversos autores, de distintas áreas acadêmicas, o artigo aponta para a mportância de cada um deles na construção de uma análise que traduza a pluralidade de pontos de vista coexistentes na região e que são, muitas vezes, inconciliáveis.THE ARTICLE presents a cartography of the social situation of the Brazilians and its descendants who live in Paraguay. The distinct maps (articles, these and reports deconstruct the media’s narratives and the conception of the region as a "difficult place". Works of diverse authors, of distinct academic areas, demonstrate the importance of each one of them in the construction of an analysis that translates the plurality of points of view.

  16. A biotecnologia na agropecuária

    Directory of Open Access Journals (Sweden)

    João Lúcio de Azevedo

    1986-11-01

    Full Text Available This review reports the use of biotechnology in agriculture and animal husbandry. The main techniques and the most important products both in experimental stage or in commercial use are reported. The work intends to give a global vision to the theme, chronologically and spacely, showing the main lines of research and what has been obtained in this area. The techniques and products that are related to genetics and breeding are emphasized. Revisão Bibliográfica do emprego da biotecnologia na agropecuária, mostrando um levantamento das técnicas mais promissoras e de seus principais produtos, tanto em fase experimental como em uso comercial. Pretende-se dar uma visão global do assunto, cronológica e espacialmente, não se prendendo à detalhes, mostrando, em Unhas gerais, o que foi feito e o que se faz, atualmente, em biotecnologia. As técnicas e produtos que influenciam a área de genética e melhoramento genético na agropecuária, são enfatizadas.

  17. The NA62 GigaTracker

    Science.gov (United States)

    Aglieri Rinella, G.; Alvarez Feito, D.; Arcidiacono, R.; Biino, C.; Bonacini, S.; Ceccucci, A.; Chiozzi, S.; Gil, E. Cortina; Ramusino, A. Cotta; Degrange, J.; Fiorini, M.; Gamberini, E.; Gianoli, A.; Kaplon, J.; Kluge, A.; Mapelli, A.; Marchetto, F.; Minucci, E.; Morel, M.; Noël, J.; Noy, M.; Perktold, L.; Perrin-Terrin, M.; Petagna, P.; Petrucci, F.; Poltorak, K.; Romagnoli, G.; Ruggiero, G.; Velghe, B.; Wahl, H.

    2017-02-01

    The GigaTracker is a hybrid silicon pixel detector built for the NA62 experiment aiming at measuring the branching fraction of the ultra-rare kaon decay K+ →π+ ν ν bar at the CERN SPS. The detector has to track particles in a beam with a flux reaching 1.3 MHz/mm2 and provide single-hit timing with 200 ps RMS resolution for a total material budget of less than 0.5% X0 per station. The tracker comprises three 60.8 mm×27 mm stations installed in vacuum (∼10-6 mbar) and cooled with liquid C6F14 circulating through micro-channels etched inside a few hundred micron thick silicon plates. Each station is composed of a 200 μm thick silicon sensor read out by 2×5 custom 100 μm thick ASICs, called TDCPix. Each chip contains 40×45 asynchronous pixels, 300 μm×300 μm each and is instrumented with 100 ps bin time-to-digital converters. In order to cope with the high rate, the TDCPix is equipped with four 3.2 Gb/s serialisers sending out the data. We will describe the detector and the results from the 2014 and 2015 NA62 runs.

  18. The NA62 GigaTracker

    CERN Document Server

    Perrin-Terrin, Mathieu

    2015-01-01

    The GigaTracker is an hybrid silicon pixel detector built for the NA62 experiment aiming at measuring the branching fraction of the ultra-rare kaon decay K + ! p + n ̄ n at the CERN SPS. The detector has to track particles in a beam with a flux reaching 1.3 MHz/mm 2 and provide single-hit timing with 200ps RMS resolution for a total material budget of less than 1.5 X 0 . The tracker comprises three 60.8mm 27mm stations installed in vacuum ( 10$^{-6}$ mbar) and cooled with liquid C 6 F 14 circulating through micro-channels etched inside few hundred of microns thick silicon plates. Each station is composed of a 200 m m thick silicon sensor readout by 2 x 5 cus- tom 100 m m thick ASIC, called TDCPix. Each chip contains 40 x 45 asynchronous pixels, each 300 m m x 300 m m and is instrumented with 100ps bin time-to-digital converters. In order to cope with the high rate, the TDCPix is equipped with four 3.2Gb/s serialisers sending out the data. We will describe the detector and the results from the 2014 NA62 ru...

  19. Mercosul educativo na carreira de Enfermagem

    Directory of Open Access Journals (Sweden)

    Roseli Schmoeller

    2012-10-01

    Full Text Available O Mercosul, instituído com vistas à integração econômica, política, social e cultural entre os países membros, atualmente destaca-se pelas estratégias integrativas de âmbito educacional. Este artigo aborda os movimentos acerca da formação acadêmica dos cursos de Enfermagem e o trajeto histórico de integração educacional, apresentando o Sistema de Acreditação dos Cursos Universitários do Mercosul, o ARCU-SUL, além dos setores responsáveis por esse processo e as perspectivas para a Enfermagem nos países do Mercosul. Entendemos que para o desenvolvimento de profissionais críticos, reflexivos e com compromisso político-social, é fundamental investir na formação e na qualidade dos centros de ensino em Enfermagem.

  20. NA-CORDEX: Overview and Sample Results

    Science.gov (United States)

    Bukovsky, Melissa; Mearns, Linda; Arritt, Raymond; Castro, Christopher; Chang, Hsin-I.; Christensen, Jens; Christensen, Ole; Frigon, Anne; Gutowski, William; Kjellström, Erik; Laprise, René; McGinnis, Seth; Nikulin, Grigory; Scinocca, John; Sushama, Laxmi; Winger, Katje

    2017-04-01

    The North American CORDEX program (NA-CORDEX) has produced a good number of projections of climate according to the first phase of the CORDEX program. These simulations are based on a wide range of regional and global climate models, and some matrices of combinations have resulted. The RCMs involved include: WRF, CanRCM4, CRCM5, RegCM4, RCA4, and HirHam5. Driving GCMs include: EC-EARTH, CanESM2, HadGEM2-ES, GFDL-ESM2M, MPI-ESM-LR. These GCMs nicely span the equilibrium climate sensitivity of the GCMs making up the CMIP5 suite of models. Simulations have been performed both at .44 and .22 spatial resolutions and often for both RCP8.5 and 4.5. We will present an update of the status of NA-CORDEX, an overview of the simulations, and some of the results for North America, focusing on the quality of the baseline climate simulations and the projections of precipitation and temperature.

  1. NA-CORDEX: Overview and New Results

    Science.gov (United States)

    Mearns, L.; Arritt, R. W.; Bukovsky, M. S.; Castro, C. L.; Chang, H. I.; Christensen, J. H.; Christensen, O. B.; Gutowski, W. J., Jr.; Kjellstrom, E.; Laprise, R.; McGinnis, S. A.; Nikulin, G.; Scinocca, J. F.; Sushama, L.; Frigon, A.; Winger, K.

    2017-12-01

    The North American CORDEX program (NA-CORDEX) has produced a good number of projections of climate according to the first phase of the CORDEX program. These simulations are based on a wide range of regional and global climate models, and some matrices of combinations have resulted. The RCMs involved include: WRF, CanRCM4, CRCM5, RegCM4, RCA4, and HirHam5. Driving GCMs include: EC-EARTH, CanESM2, HadGEM2-ES, GFDL-ESM2M, MPI-ESM-LR, and MPI-ESM-MR. These GCMs nicely span the equilibrium climate sensitivity of the GCMs making up the CMIP5 suite of models. Simulations have been performed both at .44 and .22 spatial resolutions and often for both RCP8.5 and 4.5. The time period for all simulations is 1950-2100. We will present an update of the results of NA-CORDEX, an overview of the simulations, and some detailed results for North America, focusing on the quality of the baseline climate simulations and the projections of precipitation and temperature. We will particularly focus on a 2 by 3 experiment with 2 RCMs driven by 3 GCMs. We also introduce a new metric for comparison of regional model results driven by GCMs of different climate sensitivities, which is regional model climate sensitivity.

  2. Autonomia e vulnerabilidade na vida dos adolescentes

    Directory of Open Access Journals (Sweden)

    Renata R. de Oliveira

    2007-05-01

    Full Text Available Este trabalho foi realizado com a finalidade de estabelecer relações entre os princípios éticos da autonomia e vulnerabilidade e a vida de adolescentes, pessoas reconhecidamente passíveis de síndromes depressivas, uso abusivo de drogas ilícitas, alcoolismo e tabagismo. Famílias desestruturadas, pais ausentes, companhia de amigos que levam a diferentes vícios, facilidade de acesso a fontes desencontradas de informações e uma sociedade indiferente afetam o desenvolvimento normal dos jovens. Considera-se, ainda, o grande desafio apresentado a profissionais de saúde em agir na busca de reduzir a vulnerabilidade dos adolescentes e permitir que os mesmo usem de autonomia com responsabilidade na tomada de decisões em suas vidas pessoais. O cuidado com os mesmos deve ser mais integral e ativo e a sociedade ainda não reconheceu adequadamente a importância de cuidar do desenvolvimento saudável desse imenso contingente humano.

  3. ESCOLA NA OU DA PRISÃO?

    Directory of Open Access Journals (Sweden)

    Elionaldo Fernandes Julião

    Full Text Available RESUMO: Embora algumas experiências estaduais de educação para jovens e adultos em situação de restrição e privação de liberdade remontem há algumas décadas, somente a partir de 2005 é que se iniciam no Brasil encaminhamentos para implementação de uma política propriamente nacional, quando os Ministérios da Educação e da Justiça iniciaram uma proposta de articulação para implementação de Programa Nacional de Educação para o Sistema Penitenciário, formulando as suas diretrizes. Fundamentado em uma concepção crítica sobre o papel do sistema penitenciário na sociedade contemporânea, analisando as suas perspectivas políticas e pedagógicas, principalmente articulando os conceitos de garantias de direitos, políticas públicas, incompletude institucional e socialização, este artigo se propõe a investir na discussão sobre o papel da educação no sistema penitenciário, mais precisamente sobre a escola localizada no espaço carcerário.

  4. Direito do poeta na literatura de cordel

    Directory of Open Access Journals (Sweden)

    Sale Mário Gaudêncio

    Full Text Available Este artigo apresenta uma análise situacional dos direitos autorais na literatura de cordel, especialmente no que se refere à proteção moral e patrimonial que é dada aos poetas populares. Justifica-se o estudo em função de não haver profundas nem atuais discussões teóricas sobre a preservação moral e patrimonial em torno das obras de cordel. Utiliza-se como metodologia a pesquisa bibliográfica relacionada a um corpusque analisa os folhetos impressos por poetas da literatura de cordel. O estudo mostra como resultados o estabelecimento de um modelo alternativo de prazos para os direitos autorais na poesia popular, além da necessidade de ruptura técnica, política e cultural. Conclui informando sobre a importância de se construir um banco de dados nacional para que se tenha conhecimento pleno do quê e como se está produzindo a literatura de cordel, além de saber quem verdadeiramente está sendo beneficiado com tais produções.

  5. Mechanochemical transformations in Li(Na)AlH4-Li(Na)NH2 systems

    International Nuclear Information System (INIS)

    Dolotko, Oleksandr; Zhang Haiqiao; Ugurlu, Ozan; Wiench, Jerzy W.; Pruski, Marek; Scott Chumbley, L.; Pecharsky, Vitalij

    2007-01-01

    Mechanochemical transformations of tetrahydroaluminates and amides of lithium and sodium have been investigated using gas volumetric analysis, X-ray powder diffraction, solid-state nuclear magnetic resonance (NMR) and transmission electron microscopy. In a transformation of LiAlH 4 and LiNH 2 taken in an 1:1 molar ratio, the amount of released hydrogen (6.6 wt.% after 30 min ball milling) was higher than in any known one pot mechanochemical process involving a hydrogen-containing solid. A total of 4.3 wt.% of hydrogen is released by the NaAlH 4 -NaNH 2 system after 60 min ball milling; and 5.2 wt.% H 2 is released when LiAlH 4 and NaNH 2 or NaAlH 4 and LiNH 2 are ball milled for 90 min and 120 min, respectively. All transformations proceed at room temperature. The mechanism of the overall transformation MAlH 4 (s) + MNH 2 (s) → 2MH(s) + AlN(s) + 2H 2 (g) was identified based on detailed spectroscopic analysis of the intermediate (M 3 AlH 6 ) and final products of the ball milling process

  6. Aspectos valorizados por porfissionais de enfermagem na higiene pessoal e na higiene corporal do paciente

    Directory of Open Access Journals (Sweden)

    Elóide André Oliveira

    2003-10-01

    Full Text Available Survey descritivo, com o qual se objetivou identificar que aspectos da higiene corporal são valorizados pelos componentes da equipe de enfermagem, na higiene corporal pessoal e na higiene corporal do paciente. A pesquisa foi desenvolvida em oito instituições públicas de saúde e a amostra foi composta por 126 profissionais de enfermagem, correspondendo a 12,8% do total de 986 componentes das equipes de enfermagem destas instituições. Na higiene corporal pessoal, chamou a atenção o fato de que os cuidados com as unhas e com os cabelos tenham suplantado, no número de citações dos profissionais de enfermagem, aspectos básicos como o cuidado com as mãos. Na higiene corporal do paciente, o banho foi o aspecto considerado mais importante pelas três categorias profissionais; a higiene oral, pelas(os enfermeiras(os e auxiliares de enfermagem; e as unhas, pelas(os enfermeiras(os e técnicas(os de enfermagem.

  7. A coprecipitation technique to prepare NaNbO3 and NaTaO3

    Indian Academy of Sciences (India)

    Unknown

    (V) oxide, tantalum(V) oxide, sodium hydroxide, ethyl alcohol, am- monium carbonate and standard ammonia solution were used and all the starting materials were of AR grade. (Loba chemie). A stoichiometric amount of NaOH was dissolved ...

  8. A capoeira na escola e na Educação Física

    Directory of Open Access Journals (Sweden)

    Vinicius Thiago Melo

    2012-05-01

    Full Text Available http://dx.doi.org/10.5007/2175-8042.2011v23n37p190 Este é um ensaio de revisão bibliográfica que aborda a temática da capoeira na Escola e na Educação Física. A análise de alguns documentos oficiais demonstra que a capoeira estabelece relações concretas com a questão da educação das relações étnico-raciais e com a disciplina Educação Física. No entanto, verifica-se que nem sempre esta modalidade é reconhecida pelas suas possibilidades de participação no processo educativo, mas sim, em uma perspectiva secundária de compensação das tensões da sala de aula e auxílio no controle do comportamento e disciplina dos alunos. Assim, procurou-se refletir e fazer alguns apontamentos sobre o modo pelo qual esta prática cultural tem sido tratada na escola e na Educação Física.

  9. High-temperature phases of NaNbO3 and NaTaO3

    International Nuclear Information System (INIS)

    Darlington, C.N.W.

    1999-01-01

    The high-temperature phases of the perovskites sodium niobate, NaNbO 3 , and sodium tantalate, NaTaO 3 , have been re-examined using the high-resolution powder diffractometer HRPD at the ISIS neutron spallation source; the two materials show the same sequence of phases with tilted octahedra. Diffraction patterns were measured every 5 K allowing structural changes with temperature within a single phase to be determined for the first time. Previous structure determinations within one phase had been performed at a single temperature only. The octahedra are tilted about pseudocubic left angle 100 right angle directions and are also deformed; the magnitude of the deformation is shown to be proportional to the square of the angle of tilt as expected from a phenomenological theory applied to such transitions. The structures of NaNbO 3 between 753 and 793 K and of NaTaO 3 below 758 K are not as reported in the literature. (orig.)

  10. Na-K-Interdiffusion in Alkali Feldspars

    Science.gov (United States)

    Schaeffer, A.-K.; Petrishcheva, E.; Rhede, D.; Abart, R.

    2012-04-01

    Exchange experiments between crystallographically oriented plates of gem-quality alkali feldspar (XOr 0.85) with NaCl/KCl melts have been conducted at 850° and 920° C. The melt composition was varied systematically between XKCl 0.6 and 1 to induce a shift of the feldspar composition towards more Na-rich as well as K-rich compositions (XOr 0.74 to 1). We applied 40-times molar excess of cations in the melt to ensure constant concentration boundary conditions for cation exchange. Depending on the direction of the composition shift diffusion profiles with different geometries develop. After a shift towards more K-rich compositions the diffusion profile shows two plateaus representing the unexchanged core and the exchanged rim in equilibrium with the melt, respectively. The exchange front between the two plateaus has an inflection point and propagates through the crystal with t1/2. Its width depends on the composition difference between the exchanged and unexchanged domains of the grain as well as crystallographic direction. The profiles that develop during a shift towards more Na-rich compositions lack an inflection point. If XOr is shifted by more than 10 mole-% crack systems begin to develop due to composition strain associated with the substitution of K+ by the smaller Na+ion. While the propagation rate of the fronts is roughly equal in all crystallographic directions, the profiles measured in the direction normal to (001) are always narrower than those normal to (010). This indicates a marked anisotropy in interdiffusion which appears fastest in the direction perpendicular to (001), i.e. c*. The observed geometry of the diffusion fronts can be explained by a composition dependence of the interdiffusion coefficient. This dependence was first described by Christoffersen et al. (1983) but these authors used a different experimental setup and only had reliable data for intermediate compositions. From our data we could extract the interdiffusion coefficient for high

  11. Efeito do plasma de oxigênio na dentina previamente exposta ao NaOCl

    Directory of Open Access Journals (Sweden)

    Maíra do PRADO

    Full Text Available Resumo Introdução O tratamento de plasma é uma tecnologia eficaz que pode manter as propriedades internas dos materiais inalteradas após o tratamento, modificando apenas a superfície. Objetivo Avaliar o efeito do plasma de oxigênio na dentina previamente exposta ao NaOCl 6%. Material e método Foram utilizados 60 incisivos bovinos. A coroa foi removida, a raiz foi dividida e as faces planificadas, totalizando 120 segmentos referentes ao terço cervical. As amostras foram divididas em dois grupos: controle (imersa em NaOCl 6%, lavada com água destilada, seca, imersa em EDTA 17%, lavada e seca e plasma de oxigênio (após tratamento descrito no grupo controle, plasma de oxigênio foi aplicado por 30 s. As amostras foram avaliadas qualitativamente em relação à topografia por microscopia eletrônica de varredura, utilizando-se microfotografias com ampliação de 1.000×. O goniômetro Ramé-hart foi utilizado para a mensuração do ângulo de contato entre as superfícies e as seguintes soluções foram utilizadas: água, etilenoglicol e di-iodometano. Em seguida, a energia de superfície, representada pelas componentes polar e dispersiva, foi calculada. Avaliou-se também o escoamento dos cimentos Pulp Canal Sealer EWT (PCS e Real Sal SE (RS na superfície dentinária. Os dados foram analisados estatisticamente utilizando os testes Kruskal-Wallis e Mann-Whitney U (p<0,05. Resultado O tratamento com plasma levou à formação de uma camada semelhante à smear layer na superfície dentinária. Este tratamento levou a um aumento da energia de superfície e da componente polar, favorecendo a hidrofilicidade da superfície. Entretanto, desfavoreceu o escoamento do cimento PCS e não influenciou no escoamento do cimento RS. Conclusão O plasma de oxigênio ocasionou mudanças topográficas na superfície dentinária, favorecendo a hidrofilicidade desta. Contudo, não favoreceu o escoamento dos cimentos endodônticos na dentina.

  12. Diffusion of Na+ AND Sr2+ tracers in compacted, saturated Na-bentonite: a predictive model

    International Nuclear Information System (INIS)

    Bourg, I.C.; Sposito, G.; Bourg, A.C.M.

    2005-01-01

    Full text of publication follows: A key characteristic of the porosity of compacted bentonite is that it is composed not only of macro- and meso-pores, but also of nanometer-thin interlayer pores. The interlayer pore water is in intimate contact with the negatively charged clay, and has a high cation concentration. Anions are strongly excluded from this region. The fluids present in interlayer pores and in the larger pores of compacted, saturated bentonite or montmorillonite have been described as distinct aqueous phases. This distinction has allowed successful explanations of, e.g., chemo-mechanical coupling in clays. However, it is not used in current models of the diffusion of tracers in compacted, saturated bentonite. We have developed a model of the diffusion of tracers in compacted, saturated Na-bentonite in which the interlayers and larger pores are described as parallel diffusion paths [1]. This model has allowed us to successfully describe the mean principal value of the apparent diffusivity tensor of water tracers in several one-dimensionally compacted, saturated Na-bentonites, in a broad range of partial montmorillonite dry density, using the direction-averaged tortuosity (τ = 1.9 ± 0.6) as a single fitted parameter [2]. We report on the application of the same model to the diffusion of Na + and Sr 2+ tracers in compacted, saturated Na-bentonite. Our model successfully predicts the ratio of the apparent diffusivities of cationic and water tracers, with no fitted parameters, as a function of both partial montmorillonite dry density and ionic strength. Furthermore, we show that a relation between the activation energy of diffusion of Na+ tracers and the partial montmorillonite dry density of Na-bentonite can be derived from our model, and can be fit to experimental data. [1] Diffusion of Water and Inorganic Ions in Compacted Saturated Bentonite, I.C. Bourg (2004), Ph.D. thesis, University of California, Berkeley; [2] Diffusion of Water Tracers in

  13. Stimulation of Na+/K+ ATPase activity and Na+ coupled glucose transport by β-catenin

    International Nuclear Information System (INIS)

    Sopjani, Mentor; Alesutan, Ioana; Wilmes, Jan; Dermaku-Sopjani, Miribane; Lam, Rebecca S.; Koutsouki, Evgenia; Jakupi, Muharrem; Foeller, Michael; Lang, Florian

    2010-01-01

    Research highlights: → The oncogenic transcription factor β-catenin stimulates the Na + /K + -ATPase. → β-Catenin stimulates SGLT1 dependent Na + , glucose cotransport. → The effects are independent of transcription. → β-Catenin sensitive transport may contribute to properties of proliferating cells. -- Abstract: β-Catenin is a multifunctional protein stimulating as oncogenic transcription factor several genes important for cell proliferation. β-Catenin-regulated genes include the serum- and glucocorticoid-inducible kinase SGK1, which is known to stimulate a variety of transport systems. The present study explored the possibility that β-catenin influences membrane transport. To this end, β-catenin was expressed in Xenopus oocytes with or without SGLT1 and electrogenic transport determined by dual electrode voltage clamp. As a result, expression of β-catenin significantly enhanced the ouabain-sensitive current of the endogeneous Na + /K + -ATPase. Inhibition of vesicle trafficking by brefeldin A revealed that the stimulatory effect of β-catenin on the endogenous Na + /K + -ATPase was not due to enhanced stability of the pump protein in the cell membrane. Expression of β-catenin further enhanced glucose-induced current (Ig) in SGLT1-expressing oocytes. In the absence of SGLT1 Ig was negligible irrespective of β-catenin expression. The stimulating effect of β-catenin on both Na + /K + ATPase and SGLT1 activity was observed even in the presence of actinomycin D, an inhibitor of transcription. The experiments disclose a completely novel function of β-catenin, i.e. the regulation of transport.

  14. Recent results and prospects for NA62 experiment

    Science.gov (United States)

    Martellotti, Silvia; Aglieri Rinella, G.; Aliberti, R.; Ambrosino, F.; Ammendola, R.; Angelucci, B.; Antonelli, A.; Anzivino, G.; Arcidiacono, R.; Azhinenko, I.; Balev, S.; Barbanera, M.; Bendotti, J.; Biagioni, A.; Bician, L.; Biino, C.; Bizzeti, A.; Blazek, T.; Blik, A.; Bloch-Devaux, B.; Bolotov, V.; Bonaiuto, V.; Boretto, M.; Bragadireanu, M.; Britton, D.; Britvich, G.; Brunetti, M. B.; Bryman, D.; Bucci, F.; Butin, F.; Capitolo, E.; Capoccia, C.; Capussela, T.; Cassese, A.; Catinaccio, A.; Cecchetti, A.; Ceccucci, A.; Cenci, P.; Cerny, V.; Cerri, C.; Checcucci, B.; Chikilev, O.; Chiozzi, S.; Ciaranfi, R.; Collazuol, G.; Conovaloff, A.; Cooke, P.; Cooper, P.; Corradi, G.; Cortina Gil, E.; Costantini, F.; Cotorobai, F.; Cotta Ramusino, A.; Coward, D.; D'Agostini, G.; Dainton, J.; Dalpiaz, P.; Danielsson, H.; Degrange, J.; De Simone, N.; Di Filippo, D.; Di Lella, L.; Di Lorenzo, S.; Dixon, N.; Doble, N.; Dobrich, B.; Duk, V.; Elsha, V.; Engelfried, J.; Enik, T.; Estrada, N.; Falaleev, V.; Fantechi, R.; Fascianelli, V.; Federici, L.; Fedotov, S.; Fiorini, M.; Fry, J.; Fu, J.; Fucci, A.; Fulton, L.; Gallorini, S.; Galeotti, S.; Gamberini, E.; Gatignon, L.; Georgiev, G.; Gianoli, A.; Giorgi, M.; Giudici, S.; Glonti, L.; Goncalves Martins, A.; Gonnella, F.; Goudzovski, E.; Guida, R.; Gushchin, E.; Hahn, F.; Hallgren, B.; Heath, H.; Herman, F.; Husek, T.; Hutanu, O.; Hutchcroft, D.; Iacobuzio, L.; Iacopini, E.; Imbergamo, E.; Jamet, O.; Jarron, P.; Jones, E.; Kampf, K.; Kaplon, J.; Kekelidze, V.; Kholodenko, S.; Khoriauli, G.; Khotyantsev, A.; Khudyakov, A.; Kiryushin, Yu.; Kleimenova, A.; Kleinknecht, K.; Kluge, A.; Koval, M.; Kozhuharov, V.; Krivda, M.; Kucerova, Z.; Kudenko, Y.; Kunze, J.; Lamanna, G.; Latino, G.; Lazzeroni, C.; Lehmann-Miotto, G.; Lenci, R.; Lenti, M.; Leonardi, E.; Lichard, P.; Lietava, R.; Litov, L.; Lollini, R.; Lomidze, D.; Lonardo, A.; Lupi, M.; Lurkin, N.; McCormick, K.; Madigozhin, D.; Maire, G.; Mandeiro, C.; Mannelli, I.; Mannocchi, G.; Mapelli, A.; Marchetto, F.; Marchevski, R.; Martellotti, S.; Massarotti, P.; Massri, K.; Matak, P.; Maurice, E.; Mefodev, A.; Menichetti, E.; Minucci, E.; Mirra, M.; Misheva, M.; Molokanova, N.; Morant, J.; Morel, M.; Moulson, M.; Movchan, S.; Munday, D.; Napolitano, M.; Neri, I.; Newson, F.; Norton, A.; Noy, M.; Nuessle, G.; Numao, T.; Obraztsov, V.; Ostankov, A.; Padolski, S.; Page, R.; Palladino, V.; Paoluzzi, G.; Parkinson, C.; Pedreschi, E.; Pepe, M.; Perez Gomez, F.; Perrin-Terrin, M.; Peruzzo, L.; Petrov, P.; Petrucci, F.; Piandani, R.; Piccini, M.; Pietreanu, D.; Pinzino, J.; Polenkevich, I.; Pontisso, L.; Potrebenikov, Yu.; Protopopescu, D.; Raffaelli, F.; Raggi, M.; Riedler, P.; Romano, A.; Rubin, P.; Ruggiero, G.; Russo, V.; Ryjov, V.; Salamon, A.; Salina, G.; Samsonov, V.; Santoni, C.; Saracino, G.; Sargeni, F.; Semenov, V.; Sergi, A.; Serra, M.; Shaikhiev, A.; Shkarovskiy, S.; Skillicorn, I.; Soldi, D.; Sotnikov, A.; Sougonyaev, V.; Sozzi, M.; Spadaro, T.; Spinella, F.; Staley, R.; Sturgess, A.; Sutcliffe, P.; Szilasi, N.; Tagnani, D.; Trilov, S.; Valdata-Nappi, M.; Valente, P.; Vasile, M.; Vassilieva, T.; Velghe, B.; Veltri, M.; Venditti, S.; Vicini, P.; Volpe, R.; Vormstein, M.; Wahl, H.; Wanke, R.; Wertelaers, P.; Winhart, A.; Winston, R.; Wrona, B.; Yushchenko, O.; Zamkovsky, M.; Zinchenko, A.; NA62 Collaboration

    2017-04-01

    The K+ →π+ ν ν ‾ decay is theoretically one of the cleanest meson decays and so a good place to look for indirect effects of new physics complementary to LHC searches. The NA62 experiment at CERN is designed to measure the branching ratio of this decay with 10% precision. NA62 was commissioned in October 2014, took data in pilot runs in 2014 and 2015. The NA62 experimental setup is illustrated and data quality is reported.

  15. RAZVOJ APLIKACIJE PRETOČNEGA VIDEA NA MOBILNEM TELEFONU

    OpenAIRE

    Horvat, Jernej

    2012-01-01

    Diplomsko delo obravnava prenos video signala iz mobilnega telefona na TV. Prenos poteka preko Wi-Fi omrežja. Na mobilnem telefonu je nameščena ustrezna Android aplikacija, ki omogoča direkten prenos video signala in nalaganje na TV sprejemnik. Pomemben dejavnik, ki prispeva, da je ta proces mogoč, je sistem IMS (IP multimedijski podsistem), ki predstavlja omrežja naslednje generacije.

  16. Transcriptional regulators of Na, K-ATPase subunits

    OpenAIRE

    Zhiqin eLi; Sigrid A Langhans

    2015-01-01

    The Na,K-ATPase classically serves as an ion pump creating an electrochemical gradient across the plasma membrane that is essential for transepithelial transport, nutrient uptake and membrane potential. In addition, Na,K-ATPase also functions as a receptor, a signal transducer and a cell adhesion molecule. With such diverse roles, it is understandable that the Na,K-ATPase subunits, the catalytic alpha-subunit, the beta-subunit and the FXYD proteins, are controlled extensively during developme...

  17. Sociologia na complexidade Sociology in complexity

    Directory of Open Access Journals (Sweden)

    Gilson Lima

    2006-06-01

    Full Text Available O artigo se propõe a fazer uma introdução didática e informativa e, ao mesmo tempo, aprofundada sobre as conseqüências da emergência do paradigma da complexidade para a Sociologia. No desenrolar da narrativa, faz comparações, o que permite ao leitor não familiarizado com a temática da ciência identificar as diferenças macroparadigmáticas pré-modernas, da modernidade simples e da emergência do paradigma da complexidade. Define e exemplifica, sempre que possível, os termos, afirmações e princípios significativos para uma melhor compreensão do tema. Faz, também, inúmeras indicações, no interior da narrativa, de autores e obras, para que aqueles que desejarem continuar, possam mergulhar mais intensamente nos caminhos da sociologia da complexidade. O artigo inicia com uma introdução que define, a partir de Thomas Kuhn, o conceito de paradigma. A seguir, desenvolve de modo comparado, os princípios mais importantes do paradigma da complexidade. E, por fim, chama a atenção para alguns desafios da Sociologia na complexidade, alertando para os riscos da paralisação da complexidade na difícil tarefa de religarmos os saberes diante da hiperespecialização presente na crise do paradigma da modernidade simples.The article is a simultaneously didactic and informative deep introduction on the emergence of the paradigm of complexity for sociology. Along the narrative, we make comparisons, which allows the reader who is not familiar with the themes of science to identify the macro-paradigmatic pre-modern differences from simple modernity and the emergence of the paradigm of complexity. Whenever it is possible, we define and exemplify the terms, assertions, and principles that are significant for an understanding of the theme. We have also made numerous indications of authors and works within the narrative, thus those willing might take a deeper dive in the pathways of sociology of complexity. The article starts with an

  18. RAHNER NA BERLINDA PÓS-CONCILIAR

    Directory of Open Access Journals (Sweden)

    Luciano Campos Lavall

    2004-01-01

    Full Text Available O artigo analisa algumas críticas negativas feitas ao pensamento teológico de Karl Rahner, após sua morte, que tentam desqualificar a sua importância para a ortodoxia católica e o seu distanciamento dos fundamentos do Concílio Vaticano II. Na discussão, enfocada sobretudo no ponto de vista da eclesiologia rahneriana, retoma importante entrevista do mesmo, no ano de sua morte, na qual aparece a sua preocupação com as chances futuras da Igreja, sobretudo na Europa Ocidental, a partir da qual abordam-se as relações entre Cristianismo e Igreja. As estratégias para a organização pastoral do mundo católico são a tônica desta reflexão. Para justificar suas posturas, o artigo termina com uma avaliação global de todo o conjunto teológico de Karl Rahner, redescobrindo nele os pilares mais fundamentais que justificam sua ortodoxia a serviço da fé cristã e católica, mas também a serviço da tomada de consciência de uma fé vivenciada e comprometida por parte da humanidade marcadamente secularizada. ABSTRACT: The article analyses negative criticisms against Rahner’s theological views after his death with the intention of discrediting him and his role in Catholic orthodoxy by distancing him from the fundamentals of Vatican Council II. In the discussion, primarily focused on Rahner’s ecclesiology, the article retakes a significant interview made the same year of Rahner’s death. In this interview his concern for the Church’s future chances, especially regarding Eastern Europe, embarking on relations between Christianity and Church. The strategies for world-wide organization of Catholic ministry predominate this reflection. Justifying its postures, the article concludes with a global evaluation of Rahner’s theology, rediscovering the fundamental pillars which justify his orthodoxy at the service of the Christian and Catholic faith, but also at the service of a conscientious living of a committed faith on behalf of a notably

  19. Characterization of ZnAl cast alloys with Na addition

    Energy Technology Data Exchange (ETDEWEB)

    Gancarz, Tomasz, E-mail: t.gancarz@imim.pl [Institute of Metallurgy and Materials Science, Polish Academy of Sciences, Krakow (Poland); Cempura, Grzegorz [AGH University of Science and Technology, International Centre of Electron Microscopy for Materials Science, Faculty of Metals Engineering and Industrial Computer Science, Krakow (Poland); Skuza, Wojciech [Institute of Metallurgy and Materials Science, Polish Academy of Sciences, Krakow (Poland)

    2016-01-15

    This study was aimed at evaluating the microstructural change and thermal, electrical and mechanical properties with the addition of Na to eutectic ZnAl alloys. Solders based on eutectic ZnAl containing 0.2 to 3.0 (wt.%) of Na were developed for high temperature solder. Differential scanning calorimetry (DSC) measurements were performed to determine the melting temperatures of the alloys. Thermal linear expansion and electrical resistivity measurements were performed over − 50 °C to 300 °C and 30 °C to 300 °C temperature ranges, respectively. The microstructure of the specimens was analyzed using scanning (SEM) and transmission electron microscopy (TEM) techniques. Chemical microanalysis was performed by energy-dispersive X-ray spectroscopy (EDS) on SEM and TEM. The precipitates of NaZn{sub 13} were confirmed by X-ray diffraction (XRD) measurements and selected area electron diffraction (SAED) techniques. The addition of Na to eutectic ZnAl alloy increased the electrical resistivity and reduced the coefficient of thermal expansion; however, the melting point did not change. The mechanical properties, strain and microhardness increased with Na content in alloys. - Highlights: • High temperature soldering materials of ZnAl with Na were designed and characterized. • Precipitates of NaZn{sub 13}were observed and confirmed using TEM and XRD. • Addition of Na to eutectic ZnAl cussed increased mechanical properties. • NaZn{sub 13} caused increased electrical resistivity and microhardness, and reduced the CTE.

  20. Dejavniki psihološkega nasilja na delovnem mestu

    OpenAIRE

    Ilc, Teja

    2011-01-01

    Raziskave na področju delovnih razmer kažejo, da je danes pereč problem ravno psihološko nasilje na delovnem mestu. Posebna oblika psihološkega nasilja na delovnem mestu je mobing, s katerim se v praksi srečujemo vsak dan, vendar se ga pogosto ne zavedamo. Namen magistrske naloge je pojasniti pojem in pomen mobinga v delovnih organizacijah, poiskati možne vzroke in posledice, ki vplivajo na ta pojav, ter predlagati rešitve. Poznavanje mehanizmov, ki povzročajo mobing, njegovih vzrokov in...

  1. VLOGA ETIKE PRI PREPREČEVANJU NADLEGOVANJA NA DELOVNEM MESTU

    OpenAIRE

    Sambolec, Katja

    2013-01-01

    V diplomskem seminarju smo obravnavali temo z naslovom Vpliv etike pri preprečevanju nadlegovanja na delovnem mestu. Tema o nadlegovanju na delovnem mestu, je aktualna že desetletja in glede na gospodarsko krizo, ki ji še ni videti konca, je aktualna še danes. Zaradi prenasičenosti trga s ponudniki iste branže, se posledično v posameznih podjetjih izvajajo pritiski na zaposlene, ki v različnih situacijah vodijo do nadlegovanja. Pri pisanju diplomskega seminarja smo se najprej osredotoči...

  2. Influenza virus neuraminidase (NA): a target for antivirals and vaccines.

    Science.gov (United States)

    Jagadesh, Anitha; Salam, Abdul Ajees Abdul; Mudgal, Piya Paul; Arunkumar, Govindakarnavar

    2016-08-01

    Influenza, the most common infectious disease, poses a great threat to human health because of its highly contagious nature and fast transmissibility, often leading to high morbidity and mortality. Effective vaccination strategies may aid in the prevention and control of recurring epidemics and pandemics associated with this infectious disease. However, antigenic shifts and drifts are major concerns with influenza virus, requiring effective global monitoring and updating of vaccines. Current vaccines are standardized primarily based on the amount of hemagglutinin, a major surface antigen, which chiefly constitutes these preparations along with the varying amounts of neuraminidase (NA). Anti-influenza drugs targeting the active site of NA have been in use for more than a decade now. However, NA has not been approved as an effective antigenic component of the influenza vaccine because of standardization issues. Although some studies have suggested that NA antibodies are able to reduce the severity of the disease and induce a long-term and cross-protective immunity, a few major scientific issues need to be addressed prior to launching NA-based vaccines. Interestingly, an increasing number of studies have shown NA to be a promising target for future influenza vaccines. This review is an attempt to consolidate studies that reflect the strength of NA as a suitable vaccine target. The studies discussed in this article highlight NA as a potential influenza vaccine candidate and support taking the process of developing NA vaccines to the next stage.

  3. O grotesco na imagem publicitária

    OpenAIRE

    Silva, Maria João Barros

    2013-01-01

    O significado da palavra grotesco teve um começo puramente artístico numa descoberta, de imagens de figuras humanas deformadas e alteradas. No entanto, este foi evoluindo e adotando novos significados mais amplos e concretos na atualidade. É possível encontrar vários exemplos do grotesco em várias plataformas, como no cinema, na televisão e na literatura. Neste sentido, para se poder proceder ao estudo desta temática é fundamental a conquista do conhecimento sobre o estatuto do grotesco na pu...

  4. DISKRIMINACIJA PRI ZAPOSLOVANJU IN DELU NA PODLAGI SPOLNE USMERJENOSTI

    OpenAIRE

    Markovič, Polona

    2012-01-01

    Ustavno zagotovljena pravica do enakosti, brez kakršnegakoli razlikovanja na podlagi osebnih okoliščin, predstavlja eno izmed temeljnih človekovih pravic. Za zagotavljanje enakega obravnavanja posameznikov in različnih skupin oseb na vseh področjih družbenega življenja je neizogibno potrebna natančna zakonska opredelitev varstva pred diskriminacijo. Prepoved diskriminacije je pravno regulirana v določilih mnogih dokumentov, sprejetih na mednarodni in nacionalni ravni. Diskriminacijo lahko naj...

  5. Cafeína e desempenho em atividade de endurance?

    OpenAIRE

    Souza Junior, Tácito Pessoa de; Capitani, Caroline Dario; Loturco Filho, Irineu; Viveiros, Luis; Aoki, Marcelo Saldanha

    2012-01-01

    A cafeína é frequentemente consumida por atletas, por causa dos seus possíveis efeitos ergogênicos. É preconizado que a cafeína maximize a performance por agir, independentemente, ou concomitamente, através de 3 mecanismos: 1) aumento da mobilização do cálcio intracelular, 2) aumento na oxidação de ácidos graxos livres e 3) antagonista do receptor de adenosina no sistema nervoso central. Estudos iniciais sugeriram que o efeito ergogênico da cafeína estava relacionado ao aumento da oxidaçã...

  6. Transcriptional regulators of Na, K-ATPase subunits

    Directory of Open Access Journals (Sweden)

    Zhiqin eLi

    2015-10-01

    Full Text Available The Na,K-ATPase classically serves as an ion pump creating an electrochemical gradient across the plasma membrane that is essential for transepithelial transport, nutrient uptake and membrane potential. In addition, Na,K-ATPase also functions as a receptor, a signal transducer and a cell adhesion molecule. With such diverse roles, it is understandable that the Na,K-ATPase subunits, the catalytic alpha-subunit, the beta-subunit and the FXYD proteins, are controlled extensively during development and to accommodate physiological needs. The spatial and temporal expression of Na,K-ATPase is partially regulated at the transcriptional level. Numerous transcription factors, hormones, growth factors, lipids and extracellular stimuli modulate the transcription of the Na,K-ATPase subunits. Moreover, epigenetic mechanisms also contribute to the regulation of Na,K-ATPase expression. With the ever growing knowledge about diseases associated with the malfunction of Na,K-ATPase, this review aims at summarizing the best-characterized transcription regulators that modulate Na,K-ATPase subunit levels. As abnormal expression of Na,K-ATPase subunits have been observed in many carcinoma, we will also discuss transcription factors that are associated with epithelial-to-mesenchymal transition, a crucial step in the progression of many tumors to malignant disease.

  7. Cathode Dependence of Liquid-Alloy Na-K Anodes.

    Science.gov (United States)

    Xue, Leigang; Gao, Hongcai; Li, Yutao; Goodenough, John B

    2018-03-07

    Alkali ions can be plated dendrite-free into a liquid alkali-metal anode. Commercialized Na-S battery technology operates above 300 °C. A low-cost Na-K alloy is liquid at 25 °C from 9.2 to 58.2 wt% of sodium; sodium and/or potassium can be plated dendrite-free in the liquid range at room temperature. The co-existence of two alkali metals in an anode raises a question: whether the liquid Na-K alloy acts as a Na or a K anode. Here we show the alkali-metal that is stripped from the liquid Na-K anode is dependent on the preference of the cathode host. It acts as the anode of a sodium rechargeable cell if the cathode host structure selectively accepts only Na + ions; as the anode of a potassium rechargeable cell if the cathode accepts K + ions in preference to Na + ions. This dual-anode behavior means the liquid Na-K alkali-alloy can be applied as a dendrite-free anode in Na-metal batteries as well as K-metal batteries.

  8. Scintillation efficiency measurement of Na recoils in NaI(Tl) below the DAMA/LIBRA energy threshold

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Jingke; Shields, Emily; Calaprice, Frank; Westerdale, Shawn; Froborg, Francis; Suerfu, Burkhant; Alexander, Thomas; Aprahamian, Ani; Back, Henning O.; Casarella, Clark; Fang, Xiao; Gupta, Yogesh K.; Ianni, Aldo; Lamere, Edward; Lippincott, W. Hugh; Liu, Qian; Lyons, Stephanie; Siegl, Kevin; Smith, Mallory; Tan, Wanpeng; Kolk, Bryant Vande

    2015-07-01

    The dark matter interpretation of the DAMA modulation signal depends on the NaI(Tl) scintillation efficiency of nuclear recoils. Previous measurements for Na recoils have large discrepancies, especially in the DAMA/LIBRA modulation energy region. We report a quenching effect measurement of Na recoils in NaI(Tl) from 3 to 52 keVnr, covering the whole DAMA/LIBRA energy region for dark matter-Na scattering interpretations. By using a low-energy, pulsed neutron beam, a double time-of-flight technique, and pulse-shape discrimination methods, we obtained the most accurate measurement of this kind for NaI(Tl) to date. The results differ significantly from the DAMA reported values at low energies but fall between the other previous measurements. We present the implications of the new quenching results for the dark matter interpretation of the DAMA modulation signal.

  9. Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy.

    Science.gov (United States)

    Felippe Gonçalves-de-Albuquerque, Cassiano; Ribeiro Silva, Adriana; Ignácio da Silva, Camila; Caire Castro-Faria-Neto, Hugo; Burth, Patrícia

    2017-04-21

    Lung cancer is a leading cause of global cancer deaths. Na/K-ATPase has been studied as a target for cancer treatment. Cardiotonic steroids (CS) trigger intracellular signalling upon binding to Na/K-ATPase. Normal lung and tumour cells frequently express different pump isoforms. Thus, Na/K-ATPase is a powerful target for lung cancer treatment. Drugs targeting Na/K-ATPase may induce apoptosis and autophagy in transformed cells. We argue that Na/K-ATPase has a role as a potential target in chemotherapy in lung cancer treatment. We discuss the effects of Na/K-ATPase ligands and molecular pathways inducing deleterious effects on lung cancer cells, especially those leading to apoptosis and autophagy.

  10. Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy

    Directory of Open Access Journals (Sweden)

    Cassiano Felippe Gonçalves-de-Albuquerque

    2017-04-01

    Full Text Available Lung cancer is a leading cause of global cancer deaths. Na/K-ATPase has been studied as a target for cancer treatment. Cardiotonic steroids (CS trigger intracellular signalling upon binding to Na/K-ATPase. Normal lung and tumour cells frequently express different pump isoforms. Thus, Na/K-ATPase is a powerful target for lung cancer treatment. Drugs targeting Na/K-ATPase may induce apoptosis and autophagy in transformed cells. We argue that Na/K-ATPase has a role as a potential target in chemotherapy in lung cancer treatment. We discuss the effects of Na/K-ATPase ligands and molecular pathways inducing deleterious effects on lung cancer cells, especially those leading to apoptosis and autophagy.

  11. The NA49 large acceptance hadron detector

    CERN Document Server

    Afanasiev, S V; Appelshäuser, H; Bächler, J; Barna, D; Barnby, L S; Bartke, Jerzy; Barton, R A; Betev, L; Bialkowska, H; Bieser, F; Billmeier, A; Blyth, C O; Böck, R K; Bormann, C; Bracinik, J; Brady, F P; Brockmann, R; Brun, R; Buncic, P; Caines, H L; Cebra, D; Cooper, G E; Cramer, J G; Csató, P; Cyprian, M; Dunn, J; Eckardt, V; Eckhardt, F; Empl, T; Eschke, J; Ferguson, M I; Fessler, H; Fischer, H G; Flierl, D; Fodor, Z; Frankenfeld, Ulrich; Foka, P Y; Freund, P; Friese, V; Ftácnik, J; Fuchs, M; Gabler, F; Gál, J; Ganz, R E; Gazdzicki, M; Gladysz-Dziadus, E; Grebieszkow, J; Günther, J; Harris, J W; Hegyi, S; Henkel, T; Hill, L A; Hlinka, V; Huang, I; Hümmler, H; Igo, G; Irmscher, D; Ivanov, M; Janik, R; Jacobs, P; Jones, P G; Kadija, K; Kolesnikov, V I; Kowalski, M; Lasiuk, B; Lévai, Peter; Liebicher, K; Lynen, U; Malakhov, A I; Margetis, S; Markert, C; Marks, C; Mayes, B W; Melkumov, G L; Mock, A; Molnár, J; Nelson, J M; Oldenburg, M; Odyniec, Grazyna Janina; Pálla, G; Panagiotou, A D; Pestov, Yu N; Petridis, A; Pikna, M; Pimpl, W; Pinsky, L; Piper, A; Porter, R J; Poskanzer, A M; Poziombka, S; Prindle, D J; Pühlhofer, F; Rauch, W; Reid, J G; Renfordt, R E; Retyk, W; Ritter, H G; Röhrich, D; Roland, C; Roland, G; Rudolph, H; Rybicki, A; Sammer, T; Sandoval, A; Sann, H; Schäfer, E; Schmidt, R; Schmischke, D; Schmitz, N; Schönfelder, S; Semenov, A Yu; Seyboth, J; Seyboth, P; Seyerlein, J; Siklér, F; Sitár, B; Skrzypczak, E; Squier, G T A; Stelzer, H; Stock, Reinhard; Strmen, P; Ströbele, H; Struck, C; Susa, T; Szarka, I; Szentpétery, I; Szymanski, P; Sziklai, J; Toy, M; Trainor, T A; Trentalange, S; Ullrich, T S; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wang, F; Weerasundara, D D; Wenig, S; Whitten, C; Wieman, H H; Wienold, T; Wood, L; Yates, T A; Zimányi, J; Zhu, X Z; Zybert, R

    1999-01-01

    The NA49 detector is a wide acceptance spectrometer for the study of hadron production in p+p, p+A, and A+A collisions at the CERN SPS. The main components are 4 large volume TPCs for tracking and particle identification via $dE/dx$. TOF scintillator arrays complement particle identification. Calorimeters for transverse energy determination and triggering, a detector for centrality selection in p+A collisions, and beam definition detectors complete the set-up. A description of all detector components is given with emphasis on new technical realizations. Performance and operational experience are discussed in particular with respect to the high track density environment of central Pb+Pb collisions.

  12. Sexo e sexualidade na terceira idade

    OpenAIRE

    Nery, Valeria Alves da Silva; UESB; Valença, Tatiane Dias Casimiro; UESB

    2014-01-01

    Muitos idosos ainda encaram o envelhecer como sinônimo de decadência e isolamento, doenças e peso social, sendo que a sociedade impõe aos idosos, tabus, privando-lhe de re-pensar a sexualidade, o corpo, o prazer, a prática do sexo, levando-os a enfrentar várias dificuldades de adaptação a esse estágio da vida. O objetivo geral deste estudo foi Analisar as percepções sobre sexo e sexualidade na terceira idade. Quanto aos objetivos específicos, busca-se: averiguar se os idosos continuam tendo v...

  13. Bullying: ato esburacado na angústia

    Directory of Open Access Journals (Sweden)

    Maria de Lourdes Soares Ornellas

    2012-04-01

    Full Text Available A noção de afeto está no campo do (desprazer, resultante de uma experiência afetiva de satisfação ou insatisfação, e que se manifesta nas necessidades do sujeito. Pode-se dizer que o afeto envolve a ambivalência de sentimentos, do mais agradável ao mais insuportável, e desempenha um papel estruturante para que o sujeito reencontre sua estrutura psíquica, exercendo uma ação mediadora e decisiva sobre a constituição do sujeito do desejo, orientando o seu projeto de vida, sua profissão, sua opção sexual, etc. Essa ambivalência de afetos deve ser exercitada na educação familiar e escolar, na fala e na escuta que o afeto (desprazeroso tem relevância e parece ser silenciado. O desprazer pode ser escandido pelos sintomas medo, depressão, irritabilidade, ansiedade, humilhação. Assim posto o bullying é também conhecido como a síndrome da humilhação. O objetivo da humilhação é a tentativa de destruição do sujeito; a perda da identificação revela um fantasma, na medida em que própria vítima se sente culpada por sofrer ou por estar sofrendo um ato esburacado porque uma das peças não é encontrada e, em lugar do encaixe, o que se mostra é um buraco, o que provoca a angústia entre quem perde e aquele que ganha. ABSTRACT: The notion of affect is thus in the field of (dis pleasure, resulting from an affective experience of satisfaction or dissatisfaction, and that manifests itself on the needs of the subject. You could say that the affection involves the ambivalence of feelings, the more enjoyable the more unbearable, and plays a structural role for the subject to rediscover his psychic structure, exerting a mediator and decisive action on the constitution of the subject of desire, directing the its design life, your profession, your sexual orientation, etc.. This ambivalence of feelings should be exercised in family education and school, talking and listening that affect (dis pleasure is relevant and appears to be

  14. Redes sociais na internet: Sociabilidades emergentes

    OpenAIRE

    Amaral, Inês

    2016-01-01

    Na actual era da cultura digital é imperativo identificar e compreender os tipos de sociabilidade que emergem das novas práticas e relações que ocorrem no ciberespaço, para que seja possível teorizar sobre realidades sociais que são desenhadas em torno da apropriação do conteúdo e materializadas em plataformas que se assumem como o termómetro de uma sociedade sem determinismo geográfico. A sociabilização em contexto digital reporta-se ao princípio de que um mundo de informação (conteúdos, ...

  15. O retorno do religioso na contemporaneidade

    Directory of Open Access Journals (Sweden)

    Tiago Ribeiro Nunes

    2008-12-01

    Full Text Available O presente trabalho pretende analisar os novos modos de relação, entre a civilização e o sagrado, que emergem no contexto da contemporaneidade. Partindo principalmente das formulações freudianas e lacanianas sobre o tema, nosso objetivo primordial ao longo deste artigo é estabelecer parâmetros para compreender a ocorrência do "retorno ao sagrado no exato momento em que a humanidade enfrenta crises cada vez mais profundas e permanentes. Tal empreendimento nos permitirá verificar até que ponto o fortalecimento dos movimentos religiosos pode ser considerado como uma das conseqüências da queda dos referenciais que se realiza na contemporaneidade.

  16. Topicos na classe dos grafos clique

    OpenAIRE

    Luis Arturo Perez Lozada

    1996-01-01

    Resumo: Uma dique de um grafo G é um conjunto de vértices que induz um subgrafo completo maximal de G. O grafo dique K(G) de um grafo G é o grafo interseção das diques de G. Indutivamente define-se o i-ésimo grafo dique iterado de G como Ki(G) = K(Ki-l(G)). Apresenta-se de maneira organizada uma compilação de pesquisas realizadas nos últimos anos a respeito de diversos tópicos na dasse dos grafos dique, entre eles: o estudo das propriedades dos grafos dique de conhecidas dasses de grafos; a c...

  17. A TATUAGEM: NO CORPO E NA ESCRITA

    OpenAIRE

    Coito, Roselene de Fátima

    2007-01-01

    Entendendo a narrativa como uma negociação de sentidos, faremos uma reflexão sobre identidade a partir de marcas. A identidade na construção discursiva, no conto A hora e a vez de Augusto Matraga, de Guimarães Rosa, vale-se de dois olhares nesta reflexão: da marca tatuada no corpo de Matraga e de Matraga como marca circular da narrativa, pois Matraga é a marca da brasa que queima com ferro o corpo e também a página em branco tatuada pela escrita, o que faz do corpo, a escrita e da escrita, o ...

  18. Solubility of NaNd(CO3)2.6H2O(c) in concentrated Na2CO3 and NaHCO3 solutions

    International Nuclear Information System (INIS)

    Rao, L.; Rai, D.; Felmy, A.R.; Fulton, R.W.; Novak, C.F.

    1996-01-01

    NaNd(CO 3 ) 2 x 6 H 2 O(c) was identified to be the final equilibrium solid phase in suspensions containing concentrated sodium carbonate (0.1 to 2.0 M) and sodium bicarbonate (0.1 to 1.0 M), with either NaNd(CO 3 ) 2 x 6 H 2 O(c) or Nd 2 (CO 3 ) 3 x xH 2 O(s) as initial solids. A thermodynamic model, based on Pitzer's specific into-interaction approach, was developed to interpret the solubility of NaNd(CO 3 ) 2 x 6 H 2 O(c) as functions of sodium carbonate and sodium bicarbonate concentrations. In this model, the solubility data of NaNd(CO 3 ) 2 x 6 H 2 O(c) were explained by assuming the formation of NdCO 3 + , Nd(CO 3 ) 2 - and Nd(CO 3 ) 3 3- species and invoking the specific ion interactions between Na + and Nd(CO 3 ) 3 3- . Ion interaction parameters for Na + -Nd(CO 3 ) 3 3- were developed to fit the solubility data. Based on the model calculations, Nd(CO 3 ) 3 3- was the predominant aqueous neodymium species in 0.1 to 2 M sodium carbonate and 0.1 to 1 M sodium bicarbonate solutions. The logarithm of the NaNd(CO 3 ) 2 x 6 H 2 O solubility product (NaNd(CO 3 ) 2 x 6 H 2 O(c)=Na + +Nd 3+ +2 CO 3 2- +6 H 2 O) was calculated to be -21.39. This model also provided satisfactory interpretation of the solubility data of the analogous Am(III) system in less concentrated carbonate and bicarbonate solutions. (orig.)

  19. Porta-enxertos utilizados na citricultura

    Directory of Open Access Journals (Sweden)

    Schäfer Gilmar

    2001-01-01

    Full Text Available A muda cítrica é o insumo mais importante na formação de um pomar. As características mais importantes da muda cítrica são a origem do enxerto e do porta-enxerto, a qualidade do sistema radicular e a sua sanidade. Os porta-enxertos são capazes de influenciar várias características horticulturais e sanitárias nas árvores e nos frutos cítricos, como: sólidos solúveis totais, tamanho da copa e do fruto, resistência a moléstias e ao frio, distribuição da raízes, etc. O principal porta-enxerto utilizado no Brasil (cerca de 80% é o limoeiro ?Cravo? (Citrus limonia Osbeck cv. Cravo. No Rio Grande do Sul, mais especificamente, destaca-se o Poncirus trifoliata (L. Raf em mais de 90% dos pomares. Isso torna a citricultura vulnerável ao surgimento de moléstias que afetem estes porta-enxertos, como ocorreu na década de 40 em todo o Brasil com a 'Tristeza' dos citros em plantas enxertadas sobre laranjeira azeda, e, mais recentemente, com o 'declínio'. Assim, o conhecimento das características dos diversos porta-enxertos e de algumas particularidades do uso destes é de grande importância para a diversificação e escolha do porta-enxerto a ser utilizado pelo citricultor.

  20. Videogames e o aprender na complexidade

    Directory of Open Access Journals (Sweden)

    Paula Cristina Turcatto

    2016-06-01

    Full Text Available Ao conceber-se esta pesquisa, levou-se em consideração que cada ser humano aprende do seu modo pessoal e único, portanto, a proposta é pensar os videogames na sua relação com o Paradigma da Complexidade. Esta pesquisa teve como objetivo proporcionar um ambiente de encontro com diversos jogos de videogame, buscando instaurar a experimentação do novo, a abertura para o conhecer, ao habitar espaços inventivos, que valorizam a plasticidade e flexibilidade. Trata-se de uma pesquisa qualitativa, pois se propôs a trabalhar com os aspectos subjetivos como uma dimensão inseparável do conhecer. Foram 8 sujeitos de pesquisa – adolescentes – com os quais foram realizados 15 encontros, nos quais os mesmos estiveram em contato com diversos jogos de videogame. Foram utilizados diários de bordo para o registro das vivências, ancorados na metodologia cartográfica para tratamento dos registros. Os videogames propiciaram espaços para a emergência de diferentes formas de vivenciar a narrativa. Apesar de os jogos serem pré-moldados, os percursos produzidos, assim como as produções simbólicas frente ao contexto do jogo foram individuais. Jogar videogame relacionou-se ao posicionamento criador, de escrever as circunstâncias sob as quais as ações do jogo refletiram nas experiências vivenciadas pelo jogador.

  1. Insulin regulation of (Na+, K+)-ATPase

    International Nuclear Information System (INIS)

    Lytton, J.

    1985-01-01

    This thesis describes an investigation into the mechanism of insulin stimulation of (Na + ,K + )=ATPase in rat adipocytes. Two molecular forms of the catalytic subunit of the enzyme were identified and denoted α and α(+), due to their similarity to those isozymes previously described from rat brain. Insulin specifically stimulated the α(+) form of the enzyme. The two forms of the enzyme had quite different affinities for intracellular sodium ion; insulin affected only the lower affinity of α(+), shifting it toward a higher value. However, the sodium affinity of (Na + ,K + )-ATPase activity in isolated membranes was equally high for both forms of the enzyme. This suggests that the difference in sodium affinity between the two forms observed in the cell is not inherent within the structure of the sodium pump, but must depend upon a selective interaction with another molecule which has been lost upon membrane isolation. Immunoprecipitation of both the catalytic subunits either from extracts of whole cells which had been labelled with [ 32 P] orthophosphate, or from membranes which had been labelled with γ-[ 32 P]ATP demonstrated that less than 1 in 100 molecules had a covalently bound phosphate insulin had no influence on this value. The amino terminal sequences of the first 4 amino acids of the catalytic subunits of both α (isolated from rat kidney) and α(+) (from rat brainstem axolemma) were determined. The result shows two highly homologous but clearly different molecules. It can thus be concluded that the insulin sensitive version of the enzyme is not derived from the common α form by a post-translational modification

  2. LUZ, MELATONINA E ESTRESSE OXIDATIVO NA PISCICULTURA

    Directory of Open Access Journals (Sweden)

    Claudio Alberto Gellis de Mattos Dias

    2013-12-01

    Full Text Available Em peixes, como nos mamíferos, partes do sistema nervoso estão envolvidas em mecanismos para regulação dos sistemas corporais em sintonia com o meio. O fotoperíodo é traduzido em informações fisiológicas a partir da secreção de melatonina.Parece não haver barreiras morfofisiológicas para esta indolamina, isto é, a melatonina perfunde-se rapidamente em cada célula do organismo e em alguns casos interage com receptores e membrana situados na superfície celular, e parece estar ligada à ingestão de alimentos, crescimento e atividade locomotora de peixes. São moléculas importantes metabolizando espécies reativas de oxigênio a produtos inativos e, portanto, reduzindo o dano oxidativo.Este trabalho tem por objetivo fazer um breve levantamento em artigos recentes sobre luminosidade, melatonina e o estresse oxidativo em peixes, e correlaciona-los com piscicultura. Concluímos que a luminosidade parece estar ligada a produção de melatonina, e esta molécula antioxidante, que favorece a redução do estresse oxidativo, parecem melhorar o desempenho na produção de peixes em criadouros. Palavras-chave: Melatonina, estresse oxidativo, piscicultura. DOI: http://dx.doi.org/10.18561/2179-5746/biotaamazonia.v3n3p169-176

  3. Vogais na amazônia paraense

    Directory of Open Access Journals (Sweden)

    Regina Cruz

    2012-01-01

    Full Text Available Este artigo trata essencialmente de uma apresentação das ações do projeto institucional Norte Vogais vinculado ao Diretório Nacional PROBRAVO. O artigo fornece uma ideia precisa de como a equipe da UFPA vinculada ao PROBRAVO está conduzindo suas investigações sobre a variedade do português falada no Pará. O projeto Norte Vogais conta com amostras de fala de trezentos e dezoito informantes nativos do Pará no seu banco de dados. As descrições sociolinguísticas empreendidas pela equipe da UFPA priorizaram a investigação de três aspectos fonéticos em particular: a a variação das vogais médias pretônicas; b a variação das vogais médias postônicas mediais e; c a nasalidade alofônica. Os resultados obtidos reforçam a hipótese de Silva Neto (1957 de que o Pará compreenderia uma ilha dialetal na classificação de Antenor Nascente entre os dialetos do Norte do Brasil. Com o objetivo de refinar as descrições sociolingüísticas, duas novas ações se impuseram: a o mapeamento da situação sociolinguística das áreas de contato interdialetal no Pará e; b a análise acústica do sistema vocálico do português falado na Amazônia Paraense.

  4. VOGAIS NA AMAZÔNIA PARAENSE

    Directory of Open Access Journals (Sweden)

    Regina Fernandes Cruz

    2012-12-01

    Full Text Available Este artigo trata essencialmente de uma apresentação das ações do projeto institucional Norte Vogais vinculado ao Diretório Nacional PROBRAVO. O artigo fornece uma ideia precisa de como a equipe da UFPA vinculada ao PROBRAVO está conduzindo suas investigações sobre a variedade do português falada no Pará. O projeto Norte Vogais conta com amostras de fala de trezentos e dezoito informantes nativos do Pará no seu banco de dados. As descrições sociolinguísticas empreendidas pela equipe da UFPA priorizaram a investigação de três aspectos fonéticos em particular: a a variação das vogais médias pretônicas; b a variação das vogais médias postônicas mediais e; c a nasalidade alofônica. Os resultados obtidos reforçam a hipótese de Silva Neto (1957 de que o Pará compreenderia uma ilha dialetal na classificação de Antenor Nascente entre os dialetos do Norte do Brasil. Com o objetivo de refinar as descrições sociolingüísticas, duas novas ações se impuseram: a o mapeamento da situação sociolinguística das áreas de contato interdialetal no Pará e; b a análise acústica do sistema vocálico do português falado na Amazônia Paraense.

  5. Mercury's Na Exosphere from MESSENGER Data

    Science.gov (United States)

    Killen, Rosemary M.; Burger, M. H.; Cassidy, T. A.; Sarantos, M.; Vervack, R. J.; McClintock, W. El; Merkel, A. W.; Sprague, A. L.; Solomon, S. C.

    2012-01-01

    MESSENGER entered orbit about Mercury on March 18, 2011. Since then, the Ultraviolet and Visible Spectrometer (UWS) channel of MESSENGER's Mercury Atmospheric and Surface Composition Spectrometer (MASCS) has been observing Mercury's exosphere nearly continuously. Daily measurements of Na brightness were fitted with non-uniform exospheric models. With Monte Carlo sampling we traced the trajectories of a representative number of test particles, generally one million per run per source process, until photoionization, escape from the gravitational well, or permanent sticking at the surface removed the atom from the simulation. Atoms were assumed to partially thermally accommodate on each encounter with the surface with accommodation coefficient 0.25. Runs for different assumed source processes are run separately, scaled and co-added. Once these model results were saved onto a 3D grid, we ran lines of sight from the MESSENGER spacecraft :0 infinity using the SPICE kernels and we computed brightness integrals. Note that only particles that contribute to the measurement can be constrained with our method. Atoms and molecules produced on the nightside must escape the shadow in order to scatter light if the excitation process is resonant-light scattering, as assumed here. The aggregate distribution of Na atoms fits a 1200 K gas, with a PSD distribution, along with a hotter component. Our models constrain the hot component, assumed to be impact vaporization, to be emitted with a 2500 K Maxwellian. Most orbits show a dawnside enhancement in the hot component broadly spread over the leading hemisphere. However, on some dates there is no dawn/dusk asymmetry. The portion of the hot/cold source appears to be highly variable.

  6. RNA adducts with Na 2SeO 4 and Na 2SeO 3 - Stability and structural features

    Science.gov (United States)

    Nafisi, Shohreh; Manouchehri, Firouzeh; Montazeri, Maryam

    2011-12-01

    Selenium compounds are widely available in dietary supplements and have been extensively studied for their antioxidant and anticancer properties. Low blood Se levels were found to be associated with an increased incidence and mortality from various types of cancers. Although many in vivo and clinical trials have been conducted using these compounds, their biochemical and chemical mechanisms of efficacy are the focus of much current research. This study was designed to examine the interaction of Na 2SeO 4 and Na 2SeO 3 with RNA in aqueous solution at physiological conditions, using a constant RNA concentration (6.25 mM) and various sodium selenate and sodium selenite/polynucleotide (phosphate) ratios of 1/80, 1/40, 1/20, 1/10, 1/5, 1/2 and 1/1. Fourier transform infrared, UV-Visible spectroscopic methods were used to determine the drug binding modes, the binding constants, and the stability of Na 2SeO 4 and Na 2SeO 3-RNA complexes in aqueous solution. Spectroscopic evidence showed that Na 2SeO 4 and Na 2SeO 3 bind to the major and minor grooves of RNA ( via G, A and U bases) with some degree of the Se-phosphate (PO 2) interaction for both compounds with overall binding constants of K(Na 2SeO 4-RNA) = 8.34 × 10 3 and K(Na 2SeO 3-RNA) = 4.57 × 10 3 M -1. The order of selenium salts-biopolymer stability was Na 2SeO 4-RNA > Na 2SeO 3-RNA. RNA aggregations occurred at higher selenium concentrations. No biopolymer conformational changes were observed upon Na 2SeO 4 and Na 2SeO 3 interactions, while RNA remains in the A-family structure.

  7. Growth mechanism of NaClO3 and NaBrO3 crystals from aqueous ...

    Indian Academy of Sciences (India)

    Unknown

    tamura (1978) developed a sophisticated apparatus for in situ observation and studied the growth of NaClO3 crys- tals. Tsukamoto and Sunagawa (1990) made a systematic study of the growth of KCl in the presence of Pb ions. Though we have reported studies on growth of NaClO3 and NaBrO3 crystals, they were largely ...

  8. Anisotropy and polarization in charge changing collisions of C4+ with Na(3s) and laser aligned Na(3p)

    NARCIS (Netherlands)

    Hoekstra, R; Morgenstern, R; Olson, RE

    1996-01-01

    Absolute cross sections for C3+(6-->5) emission at 465.7 nm after collisions of C4+ ions with ground state Na(3s) and laser excited aligned Na(Sp) atoms are measured over the collision energy range of 3-7 keV amu(-1). For Na(3s) polarizations are observed by measuring the linear polarization of the

  9. Crystal structure of polyphosphates NaCd(PO3)3 and NaMn(PO3)3

    International Nuclear Information System (INIS)

    Murashova, E.V.; Chudinova, N.N.

    1997-01-01

    Crystal structure of NaCd(PO 3 ) 3 (1) and NaMn(PO 3 ) 3 (2) isostructural polyphosphates was determined for twin samples. Rhombic lattice parameters of (1): a = 14.678, b = 14.669, c = 14.705 A, sp. gr. P2 1 2 1 2 1 , Z = 16. The structure of compounds is of frame type. Polyphosphate chain with repetition period of 24 PO 4 tetrahedrons contacts with NaO 6 and M 2 O 6 octahedrons by means of common oxygen vertices. Similarities and differences in structure of mentioned polyphosphates and earlier analyzed NaMg(PO 3 ) 3 polyphosphate are noted [ru

  10. 43. Calmodulin regulating calcium sensitivity of Na channels

    Directory of Open Access Journals (Sweden)

    R. Vegiraju

    2016-07-01

    Full Text Available By extrapolating information from existing research and observing previous assumptions regarding the structure of the Na Channel, this experiment was conducted under the hypothesis that the Na Channel is in part regulated by the calmodulin protein, as a result proving calcium sensitivity of the Na Channel. Furthermore, we assume that there is a one to one stoichiometry between the Na Channel and the Calmodulin. There has been extensive research into the functionality and structure of sodium ion channels (Na channels, as several diseases are associated with the lack of regulation of sodium ions, that is caused by the disfunction of these Na channels. However, one highly controversial matter in the field is the importance of the protein calmodulin (CaM and calcium in Na channel function. Calmodulin is a protein that is well known for its role as a calcium binding messenger protein, and that association is believed to play an indirect role in regulating the Na channel through the Na channel’s supposed calcium sensitivity. While there are proponents for both sides, there has been relatively little research that provides strong evidence for either case. In this experiment, the effect of calmodulin on NaV 1.5 is tested by preparing a set of cardiac cells (of the human specie with the NaV 1.5 C-Termini and CaM protein, which were then to be placed in solutions with varying concentrations of calcium. We took special care to test multiple concentrations of calcium, as previous studies have tested very low concentrations, with Manu Ben-Johny’s team from the John Hopkins laboratory in particular testing up to a meager 50 micromolar, despite producing a well-respected paper (By comparison, the average Na channel can naturally sustain a concentration of almost 1-2 millimolar and on some occasions, reaching even higher concentrations. After using light scattering and observing the signals given off by the calcium interacting with these Nav1.5/Ca

  11. Estratégias na Terapêutica Transfusional na Malária e Drepanocitose

    OpenAIRE

    Barra, A

    2017-01-01

    Um mesmo mundo, diferentes realidades Apesar dos casos de malária, no mundo, terem diminuído de aproximadamente 40 milhões entre 2000 e 2015, neste último ano o número estimado de mortes por malária ainda rondou os 438.000, sendo 88% destas na região africana.(1) Em 2011 os casos de morte por malária aconteceram maioritariamente em crianças com menos de 5 anos de idade na África subsaariana.(2) As grávidas, são um grupo, com um risco aumentado de morbilidade e mortalidade, que se es...

  12. Sliding wear behaviour of steel carburized using Na2CO3-NaCl

    Directory of Open Access Journals (Sweden)

    Liew Willey Y. H.

    2017-01-01

    Full Text Available Experiments have been carried out to investigate the effect of carburization process on the sliding wear resistance of mild steel. The carburization process was conducted in carbonate salts mixtures of Na2CO3-NaCl. Carburization followed by water quenching resulted in the formation of martensite with a hardness of 900 HV in the subsurface, up to the depth of 400 μm. This hardness value was substantially higher than the non-carburized steel which had a hardness of 520 HV. In the initial stage of sliding in air, abrasive wear and cluster of fine cavities due to adhesion were formed. This was followed by the formation of large-scale fracture at the cavities. The high hardness of the carburized steel reduced the severity of adhesive wear and thus the tendency of the worn surface to fracture.

  13. Impact of childhood stress on psychopathology Impacto de estresse na infância na psicopatologia

    Directory of Open Access Journals (Sweden)

    Elisa Brietzke

    2012-12-01

    Full Text Available OBJECTIVE: Advances in our knowledge of mental disorder (MD genetics have contributed to a better understanding of their pathophysiology. Nonetheless, several questions and doubts persist. Recent studies have focused on environmental influences in the development of MDs, and the advent of neuroscientific methodologies has provided new perspectives. Early life events, such as childhood stress, may affect neurodevelopment through mechanisms such as gene-environment interactions and epigenetic regulation, thus leading to diseases in adulthood. The aim of this paper is to review the evidence regarding the role of the environment, particularly childhood stress, in the pathophysiology of MD. METHODOLOGY: We reviewed articles that evaluated environmental influences, with a particular focus on childhood trauma, brain morphology, cognitive functions, and the development of psychopathology and MD. RESULTS AND CONCLUSION: MRI studies have shown that exposure to trauma at an early age can result in several neurostructural changes, such as the reduction of the hippocampus and corpus callosum. Cognitive performance and functioning are also altered in this population. Finally, childhood stress is related to an increased risk of developing MD such as depression, bipolar disorder, schizophrenia and substance abuse. We conclude that there is robust evidence of the role of the environment, specifically adverse childhood experiences, in various aspects of MD.OBJETIVO: Avanços no conhecimento da genética dos transtornos mentais (TM contribuíram para um melhor entendimento de suas bases fisiopatológicas. No entanto, dúvidas e questões ainda persistem. Estudos recentes têm se concentrado nas influências do ambiente no desenvolvimento de TM, e o advento de metodologias neurocientíficas oferece novas perspectivas. Eventos precoces de vida, como estresse na infância, podem ser capazes de alterar o neurodesenvolvimento através de mecanismos como intera

  14. Measurement of direct CP-violation with the experiments NA31 and NA48 at CERN

    International Nuclear Information System (INIS)

    Renk, B.

    1992-01-01

    The NA31 experiment has measured the CP violation parameter var-epsilon '/var-epsilon. The result of data collected in 1988 is Re(var-epsilon '/var-epsilon)=(1.7±1.0)x10 -3 . A preliminary result of data collected in 1989 is Re(var-epsilon '/var-epsilon)=(2.1±0.9)x10 -3 . Combining these two results with the original result from the 1986 data set we obtain Re(var-epsilon '/var-epsilon)=(2.3±0.7)x10 -3 , which is a more than three standard deviation evidence for direct CP violation. A new experiment NA48 is under construction which aims for a significant reduction of the statistical and the systematical errors in order to reach a combined error not exceeding 2x10 -4

  15. O Platonismo de Russell na metafísica e na matemática

    Directory of Open Access Journals (Sweden)

    Guido Imaguire

    2005-06-01

    Full Text Available Neste artigo, analiso o surgimento e a superação do Platonismo em B. Russell, tanto na sua filosofia da matemática como na sua metafísica. Começo por explicitar os argumentos que levaram Russell a aderir ao chamado "Platonismo Proposicional" - posição que será tecnicamente relevante na definição de números. Na seção seguinte, discutirei até que ponto a teoria das descrições definidas determina, necessariamente, uma adesão ao nominalismo, e as dificuldades que surgem para o logicismo conseqüentes do abandono do platonismo. Finalmente, mostrarei como a posição madura de Russell caracteriza-se mais como um reducionismo do que propriamente como um nominalismo, e como este é fundado no princípio do mínimo vocabulário.In this paper, I analyze the emergence and the overcoming of Platonism both in Russell's philosophy of mathematics and his metaphysics. I begin by examining the arguments which led Russell to endorse a position that I term "Propositional Platonism" - this position proves to be relevant for Russell's definition of numbers. In the following section, I address the question of the extent to which Russell's theory of descriptions implies the acceptance of nominalism. Moreover, I examine the difficulties which arise for logicism, if it no longer goes hand in hand with platonism. Finally, I argue argue that Russell's mature position is to be characterized as a form of reductionism rather than as a variant of nominalism

  16. A PALAVRA DE DEUS NA VIDA E NA MISSÃO DA IGREJA

    Directory of Open Access Journals (Sweden)

    Dom Eugênio Rixen

    2009-01-01

    Full Text Available Tive a oportunidade de participar do XII Sínodo dos Bispos em Roma, de 5 a 26 de outubro de 2008. Os sínodos foram realizados após o Concílio Vaticano II, para ajudar o Santo Padre na sua missão pastoral, e como testemunho fraterno entre os bispos do mundo inteiro em comunhão com o papa.

  17. CULTURA DOS ALUNOS NA PRÉ-ESCOLA E NA "ESCOLA PRIMÁRIA"

    Directory of Open Access Journals (Sweden)

    Ruth Bernardes de Sant'Ana

    2015-06-01

    Full Text Available O objetivo deste artigo é discutir a cultura dos alunos, com ênfase na pré-escola e nos primeiros anos do Ensino Fundamental ("escola primária". As escassas teorizações sobre o assunto mostram limitações, na medida em que recaem sobre os alunos das últimas séries do Ensino Fundamental ou sobre o Ensino Médio, ou seja, sobre os adolescentes como grupo etário. A partir de dados de pesquisa de campo e de estudos teóricos, identificamos que a cultura dos alunos é uma cultura intraescolar, que se concretiza na intersecção entre a cultura infantil e a cultura escolar, com diferentes níveis de proximidade e distanciamento entre elas. Ela envolve comportamentos estratégicos infantis de oposição e de resistência às tarefas e ao poder docente. Quando a escola recusa o acolhimento da cultura infantil, esta se produz nos interstícios das atividades escolares, por vezes de maneira conflituosa.

  18. Structural basis for Na(+) transport mechanism by a light-driven Na(+) pump.

    Science.gov (United States)

    Kato, Hideaki E; Inoue, Keiichi; Abe-Yoshizumi, Rei; Kato, Yoshitaka; Ono, Hikaru; Konno, Masae; Hososhima, Shoko; Ishizuka, Toru; Hoque, Mohammad Razuanul; Kunitomo, Hirofumi; Ito, Jumpei; Yoshizawa, Susumu; Yamashita, Keitaro; Takemoto, Mizuki; Nishizawa, Tomohiro; Taniguchi, Reiya; Kogure, Kazuhiro; Maturana, Andrés D; Iino, Yuichi; Yawo, Hiromu; Ishitani, Ryuichiro; Kandori, Hideki; Nureki, Osamu

    2015-05-07

    Krokinobacter eikastus rhodopsin 2 (KR2) is the first light-driven Na(+) pump discovered, and is viewed as a potential next-generation optogenetics tool. Since the positively charged Schiff base proton, located within the ion-conducting pathway of all light-driven ion pumps, was thought to prohibit the transport of a non-proton cation, the discovery of KR2 raised the question of how it achieves Na(+) transport. Here we present crystal structures of KR2 under neutral and acidic conditions, which represent the resting and M-like intermediate states, respectively. Structural and spectroscopic analyses revealed the gating mechanism, whereby the flipping of Asp116 sequesters the Schiff base proton from the conducting pathway to facilitate Na(+) transport. Together with the structure-based engineering of the first light-driven K(+) pumps, electrophysiological assays in mammalian neurons and behavioural assays in a nematode, our studies reveal the molecular basis for light-driven non-proton cation pumps and thus provide a framework that may advance the development of next-generation optogenetics.

  19. Paisagismo e modernidade na europa na década de 1920

    Directory of Open Access Journals (Sweden)

    Euler Sandeville Júnior

    2007-12-01

    Full Text Available Experiências formais realizadas a partir do final da Primeira Guerra deram novo impulso à reformulação das concepções então correntes para os jardins. Notamos algumas tendências contrastantes que coexistiam nessa época: uma, então dominante, representada por um ambiente profissional respondendo a uma demanda particular e do Estado, de caráter conservador e nacionalista, outras, de renovação, representadas por paisagistas e por arquitetos de alguma forma vinculados às vanguardas. O objetivo deste trabalho é destacar duas tendências modernizantes atuando na produção paisagística na Europa dos anos de 1920. Uma delas, desenvolvida por paisagistas e arquitetos, mostra forte influência do cubismo e do expressionismo, convergindo para o art déco, dotada de forte conotação decorativa. Gabriel Guevrekian e Robert Mallet-Stevens, são alguns dos representantes dessa tendência. Outra tendência modernizante deve-se à atuação de representantes do nascente movimento moderno em arquitetura, tanto em sua abordagem dos jardins como também nos conceitos que empregaram na criação de espaços externos. Entre a ampla gama de experiências nesse sentido, vêem-se as posturas bem diversas apresentadas por arquitetos como Le Corbusier e Erik Gunnar Asplund.

  20. SUPERANDO CONFLITOS NA CONSTRUÇÃO DE UMA PESQUISA COLABORATIVA NA ESCOLA

    Directory of Open Access Journals (Sweden)

    Patrícia de Oliveira Rosa-Silva

    Full Text Available Resumo: Este estudo enfoca a construção de uma parceria na formação continuada de uma professora de Ciências durante o desenvolvimento de uma pesquisa colaborativa. Analisa episódios de resistências e tensões, assim como ações e reações tanto da pesquisadora como da professora que foram capazes de ajustar e superar tais conflitos para consolidar a pesquisa. O processo de formação continuada envolveu uma estratégia de intervenção reflexiva, denominada autoscopia, simulando uma "sala de espelhos" (SCHÖN, 2000, que levou a professora a refletir sobre a sua prática educativa. Os resultados demonstram que a pesquisa colaborativa, centrada no diálogo e no companheirismo, foi mediadora na solução dos conflitos vivenciados no processo e favoreceu a tomada de decisões na consolidação de estratégias de formação continuada voltadas à professora.

  1. MCHANGO WA MWALIMU J.K. NYERERE KATIKA TAFSIRI NA ...

    African Journals Online (AJOL)

    Kwa kuzingatia tafsiri mbili za J.K. Nyerere, Julius Kaizer (1963) na Mabepari wa Venus (1969), makala inaeleza: (i) kwa nini Mwalimu Nyerere alitafsiri maandishi ya Shakespeare, (ii) ufanisi wa tafsiri zake, na (iii) mchango wa tafsiri hizo. Makala inaonyesha kuwa tafsiri hizo zinazingatia mbinu za kisemantiki zaidi kuliko ...

  2. Kuingiliana kwa Lugha ya Kiswahili na Kiingereza: Uswahilishaji wa ...

    African Journals Online (AJOL)

    Kuingiliana kwa lugha ni taaluma katika uwanja wa isimu inayohusu lugha zinazoingiliana na kuathiriana. Kuingiliana kwa lugha sio jambo jipya katika dunia. Watu ambao ndio watumiaji wa lugha wamesababisha lugha kuiingiliana waliposafiri au kuhama sehemu moja hadi nyingine kutokana na sababu za kiuchumi, ...

  3. Ufundishaji wa Kusoma na Kuandika Kiswahili: Uzoefu wa Idara ya ...

    African Journals Online (AJOL)

    Makala haya yanahusu shughuli za kufundisha Kiswahili kama lugha ya kigeni katika Chuo Kikuu cha Sebha nchini Libya. Kwanza inaeleza historia ya Kiswahili – yaani kilianza lini kufundishwa kwa madhumuni gani na nani walikuwa wanzilishi. Halikadhalika makala ya naeleza utaratibu uliowekwa na idara ili kuweza ...

  4. Risbjerg: SF vandt valgkampen, NA og R tabte

    DEFF Research Database (Denmark)

    Thomsen, Søren Risbjerg

    2007-01-01

    ANALYSE: Endnu engang flyttede en valgkamp for alvor stemmer. SF gik undervejs 27 pct. frem, mens NA gik 34 pct. tilbage og R 26 pct. Udgivelsesdato: 25. november......ANALYSE: Endnu engang flyttede en valgkamp for alvor stemmer. SF gik undervejs 27 pct. frem, mens NA gik 34 pct. tilbage og R 26 pct. Udgivelsesdato: 25. november...

  5. Transmission channels through Na and Al atom wire

    DEFF Research Database (Denmark)

    Kobayashi, N.; Brandbyge, Mads; Tsukada, M.

    1999-01-01

    First-principles calculations of the transmission channels of single-atom-width Na and Al atom wires bridged between metallic jellium electrodes are presented. For the Na wire, a single channel contributes to the conduction with an almost full quantization value, 2e(2)/h. The conductance...

  6. Juhudi za Vyombo vya Habari katika Kukuza na Kueneza Kiswahili ...

    African Journals Online (AJOL)

    Vyombo vya habari ni asasi muhimu sana katika kukuza na kueneza lugha yoyote ile, hasa katika enzi hii ya utandawazi. Vyombo hivyo ni kama vile idhaa za redio, televisheni na magazeti. Katika nchi ya Kenya kuna vyombo vya habari vinavyotoa huduma anuwai kwa ajili ya kutosheleza mahitaji ya wateja wao. Katika ...

  7. Substrate Specificity of Na+,Cl-(HCO3-)-ATPase.

    Science.gov (United States)

    Yurkiv, V A; Melikhov, V I; Shubin, V S

    2016-09-01

    We studied substrate specificity of Na + ,Cl - (HCO 3 - )-ATPase. In most cases, replacement of ATP for other phosphate-containing substances resulted in not only pronounced suppression of phosphohydrolase reactions, but also dramatic changes of their responsiveness to the stimulating effect of monovalent ions. The data showed that Na + ,Cl - (HCO 3 - )-ATPase is a highly specific enzyme for ATP.

  8. utandawazi na dhima ya kiswahili kama lugha ya afrika mashariki

    African Journals Online (AJOL)

    Kutokana na kusambaa huko katika matumizi inawezekana neno “utandawazi” likawa na maana zinazotofautiana kidogo kutoka uwanja hadi uwanja. Katika kutazama fasili mbalimbali za neno hilo, makala hii inabainisha kuwa tunaweza kujua ipi ni dhana ya msingi ambayo huzingatiwa hata kama pengine maelezo ya ...

  9. Effect NaOH Concentration on Bagasse Ash Based Geopolymerization

    Directory of Open Access Journals (Sweden)

    Saloma

    2016-01-01

    Full Text Available Geopolymer is a natural adhesive material which can be developed as a substitute for cement. The natural ingredients which want to use should contain silica and alumina. This paper uses bagasse ash as a basic material of mortar geopolymer. As an adhesive, the bagasse ash should be mixed with water and another activator alkali such as sodium hydroxide (NaOH and sodium silicate (Na2SiO3. The NaOHs molarity variation are 8, 10, 12, 14 and 16 M with Na2SiO3/NaOH = 1,0 sand/bagasse ash = 2,75 and activator/bagasse ash = 0,42. This research use 50 × 50 × 50 mm cube sized specimen and conduct a compressive strength test with 3, 7, 14, 21 and 28 days. The fresh mortar test result showed that the use of NaOHs molarity variation influences the slump value and time setting. The bigger NaOH molarity variation that been used, the smaller slump value. But, the time setting is increased. While the result for density and compressive strength shown that the bigger NaOH molarity variation, the bigger density and the compressive strength. Maximum compressive strength resulted from the mixture of mortar geopolymer with 16 M concentration.

  10. Mbinu na Mikakati ya Kutumia Fasihi ya Watoto kama Bibliotherapia ...

    African Journals Online (AJOL)

    Mbinu na Mikakati ya Kutumia Fasihi ya Watoto kama Bibliotherapia. Pamela M.Y. Ngugi. Abstract. Katika ulimwengu wa sasa, sanaa ya uchoraji, dansi, muziki na hata fasihi imechukuliwa kama aina moja ya tiba kwa wagonjwa wanaougua magonjwa mbalimbali. Wataalamu wa tiba-therapia wameanza kutumia fasihi ...

  11. Transepithelial Na+ transport and the intracellular fluids: a computer study.

    Science.gov (United States)

    Civan, M M; Bookman, R J

    1982-01-01

    Computer simulations of tight epithelia under three experimental conditions have been carried out, using the rheogenic nonlinear model of Lew, Ferreira and Moura (Proc. Roy. Soc. London. B 206:53-83, 1979) based largely on the formulation of Koefoed-Johnsen and Ussing (Acta Physiol. Scand. 42: 298-308. 1958). First, analysis of the transition between the short-circuited and open-circuited states has indicated that (i) apical Cl- permeability is a critical parameter requiring experimental definition in order to analyze cell volume regulation, and (ii) contrary to certain experimental reports, intracellular Na+ concentration (ccNa) is expected to be a strong function of transepithelial clamping voltage. Second, analysis of the effects of lowering serosal K+ concentration (csK) indicates that the basic model cannot simulate several well-documented observations; these defects can be overcome, at least qualitatively, by modifying the model to take account of the negative feedback interaction likely to exist between the apical Na+ permeability and ccNa. Third, analysis of the strongly supports the concept that osmotically induced permeability changes in the apical intercellular junctions play a physiological role in conserving the body's stores of NaCl. The analyses also demonstrate that the importance of Na+ entry across the basolateral membrane is strongly dependent upon transepithelial potential, cmNa and csK; under certain conditions, net Na+ entry could be appreciably greater across the basolateral than across the apical membrane.

  12. Isolation and preliminary function analysis of a Na + /H + antiporter ...

    African Journals Online (AJOL)

    A full-length cDNA Na+/H+ antiporter gene (MzNHX1) was isolated from Malus zumi according to the homologous Na+/H+ antiporter gene region in plants. Sequence analysis indicated that the cDNA was 2062 bp in length, including an open reading frame (ORF) of 1629 bp, which encoded a predicted polypeptide of 542 ...

  13. O surto rearmamentista na América do Sul

    OpenAIRE

    Eloi Martins Senhoras

    2010-01-01

    O presente artigo objetiva analisar o processo
    de crescente rearmamento presente na América do Sul
    tomando como referência uma visão internacionalista
    fenômeno que se desdobra na região.

  14. Rotational dynamics of propylene inside Na-Y zeolite cages

    Indian Academy of Sciences (India)

    molecules etc. Several such dependences have been under investigation [2]. We have in particular been investigating the diffusivities of hydrocarbons in Na-Y ze- olitic cages. In this context we had earlier reported the translational diffusivities of propane, acetylene and 1,3-butadiene in Na-Y zeolite [3–5]. The translational.

  15. Uhusiano wa Kimatengo na Kindendeule: Ushahidi wa Kiisimu ...

    African Journals Online (AJOL)

    Licha ya utengano huo, kuna madai ya muda mrefu kwamba Kimatengo na Kindendeule ni lugha zinazofanana. Makala haya yalitumia data ya uwandani ili kupata ushahidi wa kiisimu unaoweza kueleza kiwango cha kufanana au kutofautiana baina ya lugha hizo mbili. Mbinu za hojaji na majadiliano zilitumika kupata ...

  16. Numerična in eksperimentalna analiza delovanja Teslinega ventilatorja

    OpenAIRE

    Lukačič, Rajko

    2017-01-01

    Nikola Tesla je patentiral ventilator, ki deluje na principu trenja. V diplomskem delu je opisano delovanje Teslinega ventilatorja in teoretično ozadje njegovega delovanja z namenom zmanjševanja hrupa. V sami raziskavi smo s programom Ansys izdelali numerični model, ki temelji na turbulentnem modelu k-

  17. Sepsis does not alter red blood cell glucose metabolism or Na+ concentration: A 2H-, 23Na-NMR study

    International Nuclear Information System (INIS)

    Hotchkiss, R.S.; Song, S.K.; Ling, C.S.; Ackerman, J.J.; Karl, I.E.

    1990-01-01

    The effects of sepsis on intracellular Na+ concentration ([Na+]i) and glucose metabolism were examined in rat red blood cells (RBCs) by using 23Na- and 2H-nuclear magnetic resonance (NMR) spectroscopy. Sepsis was induced in 15 halothane-anesthetized female Sprague-Dawley rats by using the cecal ligation and perforation technique; 14 control rats underwent cecal manipulation without ligation. The animals were fasted for 36 h, but allowed free access to water. At 36 h postsurgery, RBCs were examined by 23Na-NMR by using dysprosium tripolyphosphate as a chemical shift reagent. Human RBCs from 17 critically ill nonseptic patients and from 7 patients who were diagnosed as septic were also examined for [Na+]i. Five rat RBC specimens had [Na+]i determined by both 23Na-NMR and inductively coupled plasma-atomic emission spectroscopy (ICP-AES). For glucose metabolism studies, RBCs from septic and control rats were suspended in modified Krebs-Henseleit buffer containing [6,6-2H2]glucose and examined by 2H-NMR. No significant differences in [Na+]i or glucose utilization were found in RBCs from control or septic rats. There were no differences in [Na+]i in the two groups of patients. The [Na+]i determined by NMR spectroscopy agreed closely with measurements using ICP-AES and establish that 100% of the [Na+]i of the RBC is visible by NMR. Glucose measurements determined by 2H-NMR correlated closely (correlation coefficient = 0.93) with enzymatic analysis. These studies showed no evidence that sepsis disturbed RBC membrane function or metabolism

  18. Experiments on cold trap regeneration by NaH decomposition

    International Nuclear Information System (INIS)

    McPheeters, C.C.; Skladzien, S.B.; Raue, D.J.

    1979-10-01

    Cold trap regeneration may be very important in future LMFBRs because of the expected high hydrogen source from the steam generators. This hydrogen precipitates as NaH in the cold trap and may fill the trap within one year of operation. Several methods of cold trap regeneration were considered, but the simplest and least expensive appears to be decomposition of NaH under vacuum at elevated temperatures. Experiments were done to assess the feasibility of this method for cold trap regeneration. Small-scale simulated cold traps (SCT) were located with NaH and NaH plus Na 2 O, and were heated both under vacuum and under a sweep gas at 100 kPa. The evolved hydrogen was converted to water by a CuO bed and collected in a weighting tube

  19. Binary phosphates NaLnP2O7

    International Nuclear Information System (INIS)

    Anisimova, N.Yu.; Trunov, V.K.; Chudinova, N.N.

    1988-01-01

    The results of synthesis and identification of compounds of the NaLnP 2 O 7 (Ln=La,...Lu) composition are presented. 14 compounds of the above composition referring to two structural types are prepared and characterized. The data on NaLnP 2 O 7 synthesis in the Na 2 O-Ln:2O 3 -P 2 O 5 system are given. Binary phosphates of the NaLnP 2 O 7 -type (Ln=La,...Lu) are separated and identified in the subsolidus part of the Na 2 O-Ln 2 O 3 -P 2 O 5 system. Their crystallochemical parameters are determined and the presence of two structural types in the La-Lu series is shown. Thermal stability of binary phosphates is studied

  20. The New Readout System of the NA62 LKr Calorimeter

    CERN Document Server

    Ceccucci, A; Farthouat, P; Lamanna, G; Rouet, J; Ryjov, V; Venditti, S

    2015-01-01

    The NA62 experiment [1] at CERN SPS (Super Proton Synchrotron) accelerator aims at studying Kaon decays with high precision. The high resolution Liquid Krypton (LKr) calorimeter, built for the NA48 [2] experiment, is a crucial part of the photon-veto system; to cope with the demanding NA62 re- quirements,itsback-endelectron icshadtobecompletelyrenewed. The new readout system is based on the Calorimeter REAdout Module (CREAM) [3], a 6U VME board whose design and pro- duction was sub-contracted to CAEN [4], with CERN NA62 group continuously supervising the de velopment and production phase. The first version of the board was delivered by the manufacturer in March 2013 and, as of June 2014, the full board production is ongoing. In addition to describing the CREAM board, all aspects of the new LKr readout system, including its integration within the NA62 TDAQ scheme, will be treated.

  1. Na,K-pump modulates intercellular communication in vascular wall

    DEFF Research Database (Denmark)

    Matchkov, Vladimir; Nilsson, Holger; Aalkjær, Christian

      Ouabain, a specific inhibitor of the Na,K-pump, has previously been shown to interfere with intercellular communication. Here we test the hypothesis that the communication between vascular smooth muscle cells (SMCs) is regulated through an interaction between the Na,K-pump and the Na...... were used as a model for electrical coupling of SMCs by measuring membrane capacitance (Cm). SMCs were uncoupled (evaluated by inhibition of vasomotion and desynchronization of calcium transients in vascular wall, or by reduction to half of Cm measured in paired A7r5 cells) when the Na,K-pump...... was inhibited either by a low concentration of ouabain or by ATP depletion. Uncoupling with ouabain was associated with a localized increase of intracellular calcium in discrete sites near the plasma membrane. Reduction of Na,K-pump activity by removal of extracellular potassium also uncoupled cells, but only...

  2. Homocisteína e nefropatia diabética

    OpenAIRE

    Rebelo, Ana Márcia Dias

    2001-01-01

    Resumo da tese: A homocisteína é um aminoácido sulfurado que resulta do metabolismo do aminoácido essencial metionina. Após a sua síntese, pode ser metabolizada por duas vias metabólicas: remetilação e transsulfuração. Na via da remetilação a homocisteína é novamente convertida em metionina, pela aquisição de um grupo metilo a partir do 5-metil-tetrahidrofolato (via dependente da vitamina B12 e do folato) ou da betaína (via que ocorre principalmente no fígado). Na via da transsulfuração a hom...

  3. Consumo de cafeína e prematuridade

    OpenAIRE

    Souza,Rita Adriana Gomes de; Sichieri,Rosely

    2005-01-01

    A cafeína (1, 3, 7-trimetilxantina) é uma metilxantina que facilmente atravessa a barreira placentária, com quantidades substanciais passando para o líquido amniótico, sangue do cordão umbilical, plasma e urina dos neonatos. As maiores fontes de cafeína são café, chá, chocolate e refrigerantes do tipo cola. Além disso, cerca de mil drogas prescritas e 2 mil drogas não prescritas contêm cafeína, e 25 dessas drogas podem ser usadas na gravidez. Embora estudos em animais indiquem que a cafeína l...

  4. Fanfictions: leitura e escrita na cibercultura

    Directory of Open Access Journals (Sweden)

    Monica do Amparo Silva

    2017-12-01

    Full Text Available A condição letrada é um fenômeno de natureza complexa e multifacetada. Organiza-se em torno de um conjunto de gestos e comportamentos diversificados, de competências e habilidades heterogêneas, de objetos histórica e socialmente diferenciados; é construída por meio de um conjunto de práticas e de uma rede de instituições, agentes e materiais; responsável por grandes divisões no interior da sociedade e um dos fatores que poderiam transformá-la. O ingresso na cultura escrita por sociedades ocidentais já foi considerado uma das principais evoluções da era moderna. Dominar a escrita era também a produzir. Contemporaneamente, uma sociedade civilizada chega a exigir de seus membros o domínio e utilização da leitura de variados suportes em variadas formas (pois cada suporte acaba por desenvolver um modo de leitura peculiar. Pode-se, pois, inferir que o ato de ler é um ato de esforço e concentração que também exige reflexão. Dessa forma, a leitura assume o papel de um processo de disciplina intelectual, exigindo uma posição crítica daquele que é o leitor. Os ciberjovens não só consomem a leitura e toda produção midiática. Eles interagem com essa produção e realizam uma recriação cultural com identidade e público próprios denominada fanfiction cuja escrita pode ser divulgada em diferentes plataformas do ciberespaço sob diversos gêneros textuais. Este artigo é resultado da reflexão baseada na observação de um app que permite a escrita/ leitura e a divulgação dessa produção.

  5. Persistent human cardiac Na+ currents in stably transfected mammalian cells

    Science.gov (United States)

    Wang, Ging Kuo; Russell, Gabriella; Wang, Sho-Ya

    2013-01-01

    Miniature persistent late Na+ currents in cardiomyocytes have been linked to arrhythmias and sudden death. The goals of this study are to establish a stable cell line expressing robust persistent cardiac Na+ currents and to test Class 1 antiarrhythmic drugs for selective action against resting and open states. After transient transfection of an inactivation-deficient human cardiac Na+ channel clone (hNav1.5-CW with L409C/A410W double mutations), transfected mammalian HEK293 cells were treated with 1 mg/ml G-418. Individual G-418-resistant colonies were isolated using glass cylinders. One colony with high expression of persistent Na+ currents was subjected to a second colony selection. Cells from this colony remained stable in expressing robust peak Na+ currents of 996 ± 173 pA/pF at +50 mV (n = 20). Persistent late Na+ currents in these cells were clearly visible during a 4-second depolarizing pulse albeit decayed slowly. This slow decay is likely due to slow inactivation of Na+ channels and could be largely eliminated by 5 μM batrachotoxin. Peak cardiac hNav1.5-CW Na+ currents were blocked by tetrodotoxin with an IC50 value of 2.27 ± 0.08 μM (n = 6). At clinic relevant concentrations, Class 1 antiarrhythmics are much more selective in blocking persistent late Na+ currents than their peak counterparts, with a selectivity ratio ranging from 80.6 (flecainide) to 3 (disopyramide). We conclude that (1) Class 1 antiarrhythmics differ widely in their resting- vs. open-channel selectivity, and (2) stably transfected HEK293 cells expressing large persistent hNav1.5-CW Na+ currents are suitable for studying as well as screening potent open-channel blockers. PMID:23695971

  6. Modification of cloned brain Na+ channels by batrachotoxin.

    Science.gov (United States)

    Wang, G K; Wang, S Y

    1994-06-01

    The effects of batrachotoxin (BTX) on cloned alpha-subunit Na+ channels were examined in CHO-K1 cells (a chinese hamster ovary cell line) transfected with rat brain NaIIA cDNA. Under whole-cell patch clamp conditions, BTX shifted the voltage dependence of the activation process by about 45 mV towards the hyperpolarizing direction and eliminated the inactivating phase of Na+ currents. Repetitive depolarizations greatly facilitated the binding of BTX with NaIIA channels while the membrane was held at -100 mV. In chloramine-T-pretreated cells, the association rate of BTX binding with the NaIIA channel was 6.5-fold faster than that in untreated cells. The estimated association rate constant for BTX binding with the open form of NaIIA channel was 1.11 x 10(6) mol-1.s-1 at room temperature. BTX-modified NaIIA channels were blocked by tetrodotoxin (TTX) in a complicated manner. First, the TTX binding to the closed state of BTX-modified NaIIA channels was not voltage dependent. The KD value of TTX was measured at 8.9 nM, which was similar to that of unmodified channels (KD = 14.2 nM). Second, the block of the open state of BTX-modified NaIIA channels by TTX was voltage dependent; depolarization reduced the potency of TTX block between -20 mV to +50 mV. Below -30 mV, the TTX affinity began to level off, probably because of the increased presence of the closed state. Unexpectedly, steady-state inactivation of BTX-modified NaIIA channels was minimal as measured by the two-pulse protocol, a phenomenon distinctly different from that found in GH3 cells.(ABSTRACT TRUNCATED AT 250 WORDS)

  7. Single Na+ channels activated by veratridine and batrachotoxin

    Science.gov (United States)

    1987-01-01

    Voltage-sensitive Na+ channels from rat skeletal muscle plasma membrane vesicles were inserted into planar lipid bilayers in the presence of either of the alkaloid toxins veratridine (VT) or batrachotoxin (BTX). Both of these toxins are known to cause persistent activation of Na+ channels. With BTX as the channel activator, single channels remain open nearly all the time. Channels activated with VT open and close on a time scale of 1-10 s. Increasing the VT concentration enhances the probability of channel opening, primarily by increasing the rate constant of opening. The kinetics and voltage dependence of channel block by 21-sulfo-11-alpha-hydroxysaxitoxin are identical for VT and BTX, as is the ionic selectivity sequence determined by bi-ionic reversal potential (Na+ approximately Li+ greater than K+ greater than Rb+ greater than Cs+). However, there are striking quantitative differences in open channel conduction for channels in the presence of the two activators. Under symmetrical solution conditions, the single channel conductance for Na+ is about twice as high with BTX as with VT. Furthermore, the symmetrical solution single channel conductances show a different selectivity for BTX (Na+ greater than Li+ greater than K+) than for VT (Na+ greater than K+ greater than Li+). Open channel current-voltage curves in symmetrical Na+ and Li+ are roughly linear, while those in symmetrical K+ are inwardly rectifying. Na+ currents are blocked asymmetrically by K+ with both BTX and VT, but the voltage dependence of K+ block is stronger with BTX than with VT. The results show that the alkaloid neurotoxins not only alter the gating process of the Na+ channel, but also affect the structure of the open channel. We further conclude that the rate-determining step for conduction by Na+ does not occur at the channel's "selectivity filter," where poorly permeating ions like K+ are excluded. PMID:2435846

  8. Baculovirus Surface Display Using Infuenza Neuraminidase (NA Transmembrane Anchor

    Directory of Open Access Journals (Sweden)

    Irisa Trianti

    2016-11-01

    Full Text Available Baculovirus surface display has been employed as an excellent tools for presentation of foreign peptides and proteins on virus surface with native conformation, functions and immunogenicity. A baculovirus major envelope protein, gp64, or a capsid protein, vp39 are generally used as fusion partners for displaying of polypeptides on the surface of virions. Alternatively, a membrane anchoring domain of vesicular stomatitis virus G protein (VSV-G can also be used. In this study, an influenza neuraminidase (NA was proposed as a new membrane anchor for the display of Angiotensin II (AngII, DRVYIHPFHL, peptides. The AngII peptides were inserted into NA by replacing NA amino acid number 60-67 with AngII, and then integrated into a baculovirus genome. A recombinant baculovirus expressing the NA fusion-AngII peptides was generated from infected insect cells. Those peptides were found to express and translocated on the membrane of the baculovirus infected insect cell (Sf9 cell as detected by immunocytochemistry using anti-AngII monoclonal antibody. Upon budding of the recombinant baculovirus progenies through the insect cells membrane, the recombinant NA-AngII peptides was acquired to envelopes of the new baculovirus progenies. The conformation of NA on baculovirus surface was not affected by the deletion, as the 55 kDa band of NA can be detected from Western Blotting analysis by specific anti-NA monoclonal antibody. In addition, the same protein was also found by anti-AngII antibody indicating that the AngII peptides had been successfully fused with the recombinant NA. Interestingly, electron microscopy analysis demonstrated that not only the recombinant baculovirus displaying AngII peptides were generated by infected insect cells, but also the NA virus-like-particle displaying AngII peptides.

  9. Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits

    NARCIS (Netherlands)

    Baartscheer, Antonius; Schumacher, Cees A.; Wüst, Rob C.I.; Fiolet, Jan W.T.; Stienen, Ger J.M.; Coronel, Ruben; Zuurbier, Coert J.

    2017-01-01

    Aims/hypothesis: Empagliflozin (EMPA), an inhibitor of the renal sodium–glucose cotransporter (SGLT) 2, reduces the risk of cardiovascular death in patients with type 2 diabetes. The underlying mechanism of this effect is unknown. Elevated cardiac cytoplasmic Na+ ([Na+]c) and Ca2+ ([Ca2+]c)

  10. Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits

    NARCIS (Netherlands)

    Baartscheer, Antonius; Schumacher, Cees A.; Wüst, Rob C. I.; Fiolet, Jan W. T.; Stienen, Ger J. M.; Coronel, Ruben; Zuurbier, Coert J.

    2017-01-01

    Empagliflozin (EMPA), an inhibitor of the renal sodium-glucose cotransporter (SGLT) 2, reduces the risk of cardiovascular death in patients with type 2 diabetes. The underlying mechanism of this effect is unknown. Elevated cardiac cytoplasmic Na+ ([Na+](c)) and Ca2+ ([Ca2+](c)) concentrations and

  11. Kusheh, na minem Fatu, en mi na koko farmer Hello, I am Fatu and I am a cocoa farmer

    NARCIS (Netherlands)

    Witteveen, L.M.; Goris, Margriet; Lie, R.; Ingram, V.J.

    2016-01-01

    This document reports on the development of a prototype Digital Farmer Field School (DFFS) called Kusheh, na minem Fatu, en mi na koko farmer (“Hello, I am Fatu and I am a cocoa farmer”). The DFFS provides an ICT-based alternative to traditional agricultural extension. More specifically, it offers a

  12. Rescue of Na+ and H+ binding in Na+,K+-ATPase M8 aspartate mutants by secondary mutation

    DEFF Research Database (Denmark)

    Holm, Rikke; Einholm, Anja P.; Andersen, Jens Peter

    A mutation replacing the aspartate in transmembrane segment M8 in the a3-isoform of Na,K-ATPase with asparagine has been found in patients with rapid-onset dystonia parkinsonism or alternating hemiplegia of childhood. This aspartate may be a critical Na+ coordinating residue, but the crystal......-isoforms of Na,K-ATPase, and much smaller effects were seen for other mutations to the M8 aspartate, which were less disruptive of Na+ binding than mutations to other residues related to Na+ site III. The D928 (rat a1 numbering) mutations strongly diminished the cooperativity of Na+ binding. Moreover the p......H optimum of Na,K-ATPase activity was left-shifted, again with D928N being most disruptive. The reduced affinity for activating Na+ and for inhibitory protons, caused by D928N and D928A mutations, could be rescued by introduction of an additional mutation of a glutamate located far away from D928....

  13. Thermodiffusive behaviour of NaCl and KCl aqueous solutions a model for the Na-K pump

    International Nuclear Information System (INIS)

    Gaeta, F.S.; Mita, D.G.; Perna, G.; Scala, G.

    1975-01-01

    In NaCl and KCl aqueous nonisothermal solutions K + inverts its sense of migration within the physiological concentration range; Na + behaves similarly at much lower concentrations. These findings are discussed in relation to solute induced modifications of water structure and of their influence on thermal diffusion. A possible evolutionary model of a thermodiffusive mechanism for the sodium potassium pump is also suggested

  14. ESR study of Na-Colloids in heavily irradiated NaCl : Size effects and inter-precipitate interactions

    NARCIS (Netherlands)

    Vainshtein, DJ; den Hartog, H.W.

    1996-01-01

    Compared with other materials, the radiolysis processes in alkali halides and in particular NaCl have been investigated extensively. From these investigations we have obtained a rather clear picture of the radiolysis processes in these model materials. During irradiation of NaCl crystals at 50-150

  15. Endurance testing with Li/Na electrolyte

    Energy Technology Data Exchange (ETDEWEB)

    Ong, E.T.; Remick, R.J.; Sishtla, C.I. [Institute of Gas Technology, Des Plaines, IL (United States)

    1996-12-31

    The Institute of Gas Technology (IGT), under subcontract to M-C Power Corporation under DOE funding, has been operating bench-scale fuel cells to investigate the performance and endurance issues of the Li/Na electrolyte because it offers higher ionic conductivity, higher exchange current densities, lower vapor pressures, and lower cathode dissolution rates than the Li/K electrolyte. These cells have continued to show higher performance and lower decay rates than the Li/K cells since the publication of our two previous papers in 1994. In this paper, test results of two long-term 100-cm{sup 2} bench scale cells are discussed. One cell operated continuously at 160 mA/cm{sup 2} for 17,000 hours with reference gases (60H{sub 2}/20CO{sub 2}/20H{sub 2}O fuel at 75% utilization and 30CO{sub 2}/70 air oxidant humidified at room temperature at 50% utilization). The other cell operated at 160 mA/cm{sup 2} for 6900 hours at 3 atm with system gases (64H{sub 2}/16CO{sub 2}/20H{sub 2}O at 75% utilization and an M-C Power system-defined oxidant at 40% utilization). Both cells have shown the highest performance and longest endurance among IGT cells operated to date.

  16. Absorto na ação

    Directory of Open Access Journals (Sweden)

    Michael Fried

    2010-07-01

    Full Text Available O filme Zidane, um retrato do século XXI, de Douglas Gordon e Philippe Parreno (2006 pertence à tradição de absorção que desempenhou um papel crucial na evolução da arte moderna. O autor explora a tensão entre absorção e teatralidade - central tanto para a pintura francesa do século XVIII como para a fotografia dos séculos XX e XXI - e tira conseqüências estéticas e filosóficas do filme que retrata, ao longo de todos os noventa minutos de uma partida de futebol, o meio-campista francês Zinedine Zidane.Zidane, a 21st Century Portrait, a film by Douglas Gordon and Philippe Perreno, belongs to the absorptive tradition that has played a central role in the evolution of modern art. The author explores the tension between absorption and theatricality - crucial to 18th century French art as well as to 20th and 21th century photography - and draws aesthetic and philosophical consequences of this film that depicts, throughout all the 90 minutes of a soccer match, the French midfielder Zinedine Zidane.

  17. Lugares dos mortos na cristandade ocidental

    Directory of Open Access Journals (Sweden)

    Cláudia Rodrigues

    2013-01-01

    Full Text Available Resumo. Este artigo busca refletir sobre a forte associação entre morte e cristandade no Ocidente, buscando identificar os lugares dos mortos nos diferentes sistemas de cristandade. Propõe-se aqui a viabilidade de se pensar numa certa vinculação entre determinadas atitudes e representações diante da morte e do morrer e o sistema de cristandade vigente em determinados contextos históricos, entre fins da Antiguidade tardia e o século XX, mais especificamente em países nos quais a Igreja romana exerceu hegemonia sobre a sociedade. Procura argumentar que, enquanto predominou a modalidade “constantiniana”, os mortos faziam parte do cotidiano e a morte e foram instrumentos do projeto cristianizador. Quando este modelo de Cristandade recuou, diante da emergência da chamada “Cristandade pós-constantiniana” – na qual a Igreja não mais era braço do aparelho estatal –, os mortos tinham sido afastados da cidade dos vivos e a morte, ou melhor, o medo da morte não mais representava instrumento de pressão sobre a consciência do cidadão

  18. The NA62 GigaTracker

    CERN Document Server

    Aglieri Rinella, G; Arcidiacono, R; Biino, C; Bonacini, S; Ceccucci, A; Chiozzi, S; Cortina Gil, E; Cotta Ramusino, A; Degrange, J; Fiorini, M; Gamberini, E; Gianoli, A; Kaplon, J; Kluge, A; Mapelli, A; Marchetto, F; Minucci, E; Morel, M; Noël, J; Noy, M; Perktold, L; Perrin-Terrin, M; Petagna, P; Petrucci, F; Poltorak, K; Romagnoli, G; Ruggiero, G; Velghe, B; Wahl, H

    2016-01-01

    The GigaTracker is a hybrid silicon pixel detector built for the NA62 experiment aiming at measuring the branching fraction of the ultra-rare kaon decay K+→π+νν¯ at the CERN SPS. The detector has to track particles in a beam with a flux reaching 1.3 MHz/mm2 and provide single-hit timing with 200 ps RMS resolution for a total material budget of less than 0.5% X0 per station. The tracker comprises three 60.8 mm×27 mm stations installed in vacuum (∼10$^{−6}$mbar) and cooled with liquid C6F14 circulating through micro-channels etched inside a few hundred micron thick silicon plates. Each station is composed of a 200 μm thick silicon sensor read out by 2×5 custom 100 μm thick ASICs, called TDCPix. Each chip contains 40×45 asynchronous pixels, 300 μm×300 μm each and is instrumented with 100 ps bin time-to-digital converters. In order to cope with the high rate, the TDCPix is equipped with four 3.2 Gb/s serialisers sending out the data. We will describe the detector and the results from the 2014 an...

  19. Sexualidade, Espiritualidade e Conjugalidades na Wicca Brasileira

    Directory of Open Access Journals (Sweden)

    Daniela Cordovil

    Full Text Available Resumo Este artigo propõe uma análise do papel da sexualidade nas práticas da Wicca, religião neopagã surgida na Inglaterra entre 1940 e 1950. Atualmente, a Wicca é um movimento mundial multifacetado, que segue inúmeras vertentes. Esta pesquisa investiga concepções e práticas ligadas à sexualidade presentes entre grupos que praticam a Wicca publicamente em diversas capitais do Brasil. Esses grupos estão organizados em tradições (grupos religiosos com viés iniciático que comandam associações civis com fins de resguardar direitos e promover eventos públicos para divulgação e troca de conhecimento entre praticantes da religião. Os resultados do estudo mostram que a Wicca postula uma relação intrínseca entre sexualidade, espiritualidade e liberdade, sendo suas práticas herdeiras de movimentos intelectuais diversos, como o esoterismo, a contracultura e a filosofia oriental.

  20. A biologia na violência

    Directory of Open Access Journals (Sweden)

    Flores Renato Zamora

    2002-01-01

    Full Text Available As contribuições da biologia, em especial da genética do comportamento e da psicologia evolucionista, para o entendimento da violência nas sociedades contemporâneas não têm sido bem entendidas por outras áreas do conhecimento que estudam o mesmo fenômeno em níveis de maior complexidade, como as ciências sociais. Estudos recentes mostram que, no nível teórico, o descaso em relação à importância de abordagens genéticas e darwinianas da violência deixam lacunas nos modelos causais utilizados. No exercício prático da resolução de problemas sociais, a exclusão dos aspectos biológicos, como a relevância de certos estados mentais nas condutas violentas, leva à ausência de recursos de saúde e assistência social, na sociedade, para auxiliar indivíduos predispostos a comportamentos violentos a lidarem com suas circunstâncias.

  1. A Música Tradicional Madeirense na Transitoriedade

    Directory of Open Access Journals (Sweden)

    Rodolfo Cró

    2011-09-01

    Full Text Available O presente artigo procura expor, de uma forma sucinta, um conjunto de temáticas pertinentes ao contexto da música tradicional madeirense no atual panorama. Tendo como pano de fundo todas as transformações nos campos sociais, económicos e culturais, a contemporaneidade musical equaciona uma nova atitude, ou seja, uma necessidade reflexiva e crítica, face a um conjunto de elementos pluridimensionais. Contudo, a discussão em torno da globalização 1, ou seja “[…] o mundo como «aldeia global» […]” (Appadurai, 1996: 45 e da regionalização 2, ou seja, os “[…] particularismos ou culturas locais […]” (Featherstone, 2001: 84, em termos musicais, terá dese revestir numa proporção de dois conceitos, em que uma cultura conservadora dará lugar a uma cultura híbrida, no sentidoda modernidade. Tendo em conta que a evolução em princípio só se faz com programas culturais de renovação, experimentação e crítica (Canclini, 1992, é neste contexto que surgem as novas tecnologias; em concreto o software musical na sala de aula. Neste sentido, este artigo vem propor uma reflexão e um debate à luz de uma perspetiva cultural.

  2. Synthesis of Ag or Pt Nanoparticles by Hydrolysis of Either Ag2Na or PtNa

    Directory of Open Access Journals (Sweden)

    Huabin Wang

    2008-01-01

    Full Text Available Ag and Pt nanoparticles have successfully been synthesized by hydrolysis of either Ag2Na or PtNa at room temperature. The oxidation of sodium in the Pt-Na pellets was much faster than that in the Ag-Na pellets since Pt is a catalyst for H2O formation reaction from hydrogen and oxygen at room temperature. The hydrolysis byproduct, NaOH, has a high solubility and easily is removed. This method offers a simple method of preparing transition metal nanoparticles. The Ag and Pt nanoparticles prepared by this method were crystalline in nature, and spherical in shape with a mean size of around 10 nm.

  3. Artesanato na terceira idade: um estudo na cidade de Sinop no ano de 2011

    Directory of Open Access Journals (Sweden)

    Rosane Marlene Weber

    2015-04-01

    Full Text Available Essa pesquisa tem como objetivo mostrar a importância do artesanato na Terceira Idade como atividade educacional e de autonomia para os idosos. Por existir uma preocupação com a qualidade de vida da Terceira Idade e sua autonomia, nesta fase que muitos acabam ficando dependentes dos membros da família, espera-se encontrar através da arte uma motivação e uma forma de demonstrar a autoria por meio do fazer, criar e recriar com o artesanato. Aprender e ensinar são um processo contínuo na vida do ser humano, independente da idade, para Paulo Freire precisamos ter consciência de que somos inacabados, e sendo conscientes de nossa inconclusão, devemos viver num permanente movimento de busca. Essa é uma das causas pelas quais será pesquisada a prática formativa/educacional por meio do artesanato na Terceira Idade. Os motivos que levaram a escolha desta pesquisa com o artesanato na Terceira Idade é o fato de ter vivido uma experiência de trabalho na ala geriátrica de um hospital. Já o artesanato é a arte que fascina, e acreditamos que sempre há tempo para recomeçar, para descobrir algo que possa trazer qualidade para nossa vida. Devido ao crescimento cada vez maior da expectativa de vida em nosso país, cria-se uma preocupação com a qualidade de vida das pessoas da Terceira Idade. Em relação aos aspectos educacionais e culturais, esta pesquisa deseja compreender como o artesanato pode trazer motivação para as pessoas da Terceira Idade como forma de autoria e autonomia, nesta fase da vida, na cidade de Sinop, e quais os motivos que os levam a realizar esse tipo de atividade. Para investigação teórica desta pesquisa do Artesanato na Terceira Idade: um estudo na cidade de Sinop em 2011 usaremos bibliografia de vários autores, mas em especial os que dedicam seus estudos a esta faixa etária, como a coleção de Vivaidade, que tem como organizadora principal Anita Liberalesso Neri. Os autores desta coleção nos trazem a reflex

  4. Characterization and antibacterial activity of silver exchanged regenerated NaY zeolite from surfactant-modified NaY zeolite

    Energy Technology Data Exchange (ETDEWEB)

    Salim, Mashitah Mad; Malek, Nik Ahmad Nizam Nik, E-mail: niknizam@fbb.utm.my

    2016-02-01

    The antibacterial activity of regenerated NaY zeolite (thermal treatment from cetyltrimethyl ammonium bromide (CTAB)-modified NaY zeolite and pretreatment with Na ions) loaded with silver ions were examined using the broth dilution minimum inhibitory concentration (MIC) method against Escherichia coli (E. coli ATCC 11229) and Staphylococcus aureus (S. aureus ATCC 6538). X-ray diffraction (XRD), attenuated total reflectance–Fourier transform infrared (ATR–FTIR) spectroscopy, field emission scanning electron microscopy (FESEM), energy dispersive X-ray (EDX) and chemical elemental analyses were used to characterize the regenerated NaY and AgY zeolites. The XRD patterns indicated that the calcination and addition of silver ions on regenerated NaY zeolite did not affect the structure of the regenerated NaY zeolite as the characteristic peaks of the NaY zeolite were retained, and no new peaks were observed. The regenerated AgY zeolite showed good antibacterial activity against both bacteria strains in distilled water, and the antibacterial activity of the samples increased with increasing Ag loaded on the regenerated AgY zeolite; the regenerated AgY zeolite was more effective against E. coli than S. aureus. However, the antibacterial activity of the regenerated AgY was not effective in saline solution for both bacteria. The study showed that CTAB-modified NaY zeolite materials could be regenerated to NaY zeolite using thermal treatment (550 °C, 5 h) and this material has excellent performance as an antibacterial agent after silver ions loading. - Highlights: • Thermal treatment was used to regenerate surfactant modified zeolite. • The regenerated NaY zeolite formed was added with different silver loadings. • Regenerated AgY zeolite was tested for antibacterial activity on E. coli and S. aureus. • The antibacterial activity increased with increased of the amount of silver loadings. • The zeolite structure did not change with thermal and modification

  5. Rigidification of the autolysis loop enhances Na(+) binding to thrombin.

    Science.gov (United States)

    Pozzi, Nicola; Chen, Raymond; Chen, Zhiwei; Bah, Alaji; Di Cera, Enrico

    2011-11-01

    Binding of Na(+) to thrombin ensures high activity toward physiological substrates and optimizes the procoagulant and prothrombotic roles of the enzyme in vivo. Under physiological conditions of pH and temperature, the binding affinity of Na(+) is weak due to large heat capacity and enthalpy changes associated with binding, and the K(d)=80 mM ensures only 64% saturation of the site at the concentration of Na(+) in the blood (140 mM). Residues controlling Na(+) binding and activation have been identified. Yet, attempts to improve the interaction of Na(+) with thrombin and possibly increase catalytic activity under physiological conditions have so far been unsuccessful. Here we report how replacement of the flexible autolysis loop of human thrombin with the homologous rigid domain of the murine enzyme results in a drastic (up to 10-fold) increase in Na(+) affinity and a significant improvement in the catalytic activity of the enzyme. Rigidification of the autolysis loop abolishes the heat capacity change associated with Na(+) binding observed in the wild-type and also increases the stability of thrombin. These findings have general relevance to protein engineering studies of clotting proteases and trypsin-like enzymes. Copyright © 2011 Elsevier B.V. All rights reserved.

  6. Rigidification of the autolysis loop enhances Na+ binding to thrombin

    Science.gov (United States)

    Pozzi, Nicola; Chen, Raymond; Chen, Zhiwei; Bah, Alaji; Di Cera, Enrico

    2011-01-01

    Binding of Na+ to thrombin ensures high activity toward physiological substrates and optimizes the procoagulant and prothrombotic roles of the enzyme in vivo. Under physiological conditions of pH and temperature, the binding affinity of Na+ is weak due to large heat capacity and enthalpy changes associated with binding, and the Kd=80 mM ensures only 64% saturation of the site at the concentration of Na+ in the blood (140 mM). Residues controlling Na+ binding and activation have been identified. Yet, attempts to improve the interaction of Na+ with thrombin and possibly increase catalytic activity under physiological conditions have so far been unsuccessful. Here we report how replacement of the flexible autolysis loop of human thrombin with the homologous rigid domain of the murine enzyme results in a drastic (up to 10-fold) increase in Na+ affinity and a significant improvement in the catalytic activity of the enzyme. Rigidification of the autolysis loop abolishes the heat capacity change associated with Na+ binding observed in the wild-type and also increases the stability of thrombin. These findings have general relevance to protein engineering studies of clotting proteases and trypsin-like enzymes. PMID:21536369

  7. NaIrO3-A pentavalent post-perovskite

    International Nuclear Information System (INIS)

    Bremholm, M.; Dutton, S.E.; Stephens, P.W.; Cava, R.J.

    2011-01-01

    Sodium iridium (V) oxide, NaIrO 3, was synthesized by a high pressure solid state method and recovered to ambient conditions. It is found to be isostructural with CaIrO 3 , the much-studied structural analog of the high-pressure post-perovskite phase of MgSiO 3 . Among the oxide post-perovskites, NaIrO 3 is the first example with a pentavalent cation. The structure consists of layers of corner- and edge-sharing IrO 6 octahedra separated by layers of NaO 8 bicapped trigonal prisms. NaIrO 3 shows no magnetic ordering and resistivity measurements show non-metallic behavior. The crystal structure, electrical and magnetic properties are discussed and compared to known post-perovskites and pentavalent perovskite metal oxides. -- Graphical abstract: Sodium iridium(V) oxide, NaIrO 3 , synthesized by a high pressure solid state method and recovered to ambient conditions is found to crystallize as the post-perovskite structure and is the first example of a pentavalent ABO 3 post-perovskite. Research highlights: → NaIrO 3 post-perovskite stabilized by pressure. → First example of a pentavalent oxide post-perovskite. → Non-metallic and non-magnetic behavior of NaIrO 3 .

  8. Influência do Marketing Social na Imagem Corporativa

    Directory of Open Access Journals (Sweden)

    Sonia Francisca Monken

    2015-12-01

    Full Text Available Hoje, as empresas se preocupam em demonstrar afinidade com consumidores interessados em causas sociais. Alguns estudos afirmam que houve aumento na responsabilidade social das empresas e que a atitude empresarial afeta a vontade de compra dos consumidores. Este artigo buscou analisar em que medida campanhas de marketing social influenciam na imagem corporativa, incluindo identificar os principais fatores que influenciam na imagem corporativa das empresas que investem em marketing social e verificar a correlação entre os diferentes fatores que influenciam na imagem corporativa. Trata-se de estudo exploratório, quantitativo, pelo método levantamento de campo, com a aplicação de questionário auto administrado e amostra de 220 universitários. Os dados foram analisados por meio de testes estatísticos de correlação de Spearman, Mann-Whitney e Wilcoxon W. Os resultados inferem correlação linear significativa entre campanhas de marketing social e fatores que influenciam na imagem corporativa, mas não apontam correlação linear significativa entre os fatores que influenciam na imagem corporativa, investimento em marketing social e a frequência de uso dos produtos. O estudo apontou que campanhas de marketing social é um fator de influência com baixa relevância na imagem corporativa, e que os fatores de influência mais importantes são qualidade e preço.

  9. Hormonal regulation of Na -K -ATPase in cultured epithelial cells

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, J.P.; Jones, D.; Wiesmann, W.P.

    1986-08-01

    Aldosterone and insulin stimulate Na transport through mechanisms involving protein synthesis. Na -K -ATPase has been implicated in the action of both hormones. The authors examined the effect of aldosterone and insulin on Na -K -ATPase in epithelial cells in culture derived from toad urinary bladder (TB6C) and toad kidney (A6). Aldosterone, but not insulin, increases short-circuit current (I/sub sc/) in TB6C cells. Aldosterone increases Na -K -(TSP)ATPase activity after 18 h of incubation, but no effect can be seen at 3 and 6 h. Amiloride, which inhibits aldosterone-induced increases in I/sub sc/, has no effect on either basal or aldosterone stimulated enzyme activity. Both aldosterone and insulin increase I/sub sc/ in A6 cells and when added together are synergistic. Aldosterone stimulates enzyme activity in A6 cells, but insulin alone has no effect. However, aldosterone and insulin together stimulate enzyme activity more than aldosterone alone. It appears that stimulation of Na -K -ATPase activity is involved in aldosterone action in both cell lines but does not appear to be due to increased Na entry, since enhanced enzyme activity is not inhibited by amiloride. In contrast, insulin alone has no direct effect on Na -K -ATPase, although the increased enzyme activity following both agents in combination may explain their synergism on I/sub sc/.

  10. DIDÁTICA INTERDISCIPLINAR NA EAD: UMA REFLEXÃO NA ATUAÇÃO DOCENTE

    Directory of Open Access Journals (Sweden)

    Dalve Oliveira Batista Santos

    2016-12-01

    Full Text Available O presente artigo busca refletir sobre a importância da interdisciplinaridade aplicada na didática do professor da EaD no processo de construção de conhecimento. Vislumbramos nos dias atuais, uma grande preocupação por parte dos profissionais que atuam nesta modalidade de ensino. Esta preocupação refere-se principalmente as técnicas, metodologias e utilização dos recursos disponibilizados no ambiente virtual, haja vista que na maioria das vezes os profissionais que atuam nesta área não se apropriam das ferramentas que são disponibilizadas, e por isso não as tornam instrumentos que proporcionam um saber de excelência e acima de tudo dinâmico. Desta forma, percebemos a importância de se refletir acerca da didática e das práticas de ensino na atuação efetiva do professor de EaD, pois, o processo de ensino e aprendizagem cada vez mais exige profissionais de múltiplas competências, ou seja, um profissional de saber interdisciplinar, e que aja didaticamente ao compartilhar conhecimentos. Assim, compreendemos que a EaD, por se tratar de uma modalidade que promove o ensino e a aprendizagem por meio da interatividade, depende de uma didática interdisciplinar adequada para a transposição de um saber científico, e acessível aos educandos que buscam nesta modalidade uma forma de alcançar o tão desejado Ensino Superior.

  11. Tratamento das pneumonias adquiridas na comunidade na criança

    OpenAIRE

    Rodrigues, Fernanda; Lemos, Luís

    2014-01-01

    ResumoObjectivos - Avaliar a efectividade da terapêutica com amoxicilina nas pneumonias adquiridas na comunidade (PAC), admitidas no nosso Serviço de Urgência (SU), no contexto de um país em que o S. pneumoniae apresenta níveis relativamente elevados de resistência à Penicilina. Análise do impacto de propostas de tratamento anteriormente efectuadas.Material e métodos – Durante 6 meses (Outubro de 2004 a Março de 2005) foram avaliadas prospectivamente todas as crianças com PAC admitidas no SU....

  12. A maternidade na adolescência num contexto de abuso sexual na família

    OpenAIRE

    Gil, Maria José; Lucas, Patrícia

    1998-01-01

    Este artigo procura abordar as questões inerentes ii vivência da gravidez e maternidade durante a adolescência, num contexto de abuso sexual na família. Focando a análise de um caso clínico, pretende-se discutir a problemática do abuso sexual no quadro glo-. bal da violência e no quadro específico da violência sexual, detalhando especificamente as questões psicológicas inerentes ao incesto, e seu enquandramento familiar e social ABSTRACT: This article attempts to ap...

  13. A cultura na (da) periferia e a periferia na (da) mídia

    OpenAIRE

    Freitas, Guaciara Barbosa de; Universidade do Vale do Rio dos Sinos - Unisinos

    2010-01-01

    RESUMO: O presente artigo analisa o desenvolvimento de projetos culturais, por parte de atores sociais da chamada periferia, em áreas tradicionalmente segregadas das grandes cidades, articulados com elementos da cultura de massa e da comunicação midiática para conquistar uma visibilidade positiva na mídia hegemônica e chancelar a marca “cultura de periferia”. Concentramo-nos principalmente em ações focadas nos moradores de áreas de favelas do Rio de Janeiro, como Vigário Geral, onde o investi...

  14. Search for dark photons in $\\pi^0$ decays at NA48 and NA62

    CERN Document Server

    Gonnella, Francesco

    2016-01-01

    The NA48/2 experiment at CERN collected, between 2003 and 2004, $1.69 \\times 10^{7}$ fully reconstructed $\\pi^{0} \\to \\gamma e^{+}e^{-}$ in the kinematic range $m_{ee}$ > 10 MeV/$c^{2}$, with a negligible background contamination. The sample is analysed to search for the presence of dark photons (${A}'$) via the decay chain $\\pi^{0} \\to \\gamma{A}', {A}' \\to e^{+}e^{-}$. No signal has been observed, and the exclusion limits on space of the dark photon mass $m_{{A}'}$ and the mixing parameter $e^{2}$ are reported.

  15. Marketing na Internet e comportamento do consumidor: investigando a dicotomia hedonismo vs. utilitarismo na WWW

    OpenAIRE

    Gertner, David; Diaz, Andrea Narholz

    1999-01-01

    O surpreendente crescimento do número de usuários da World Wide Web e do comércio eletrônico vem despertando o interesse pela Internet por parte de pesquisadores de marketing. O presente trabalho objetiva estudar o comportamento do consumidor em atividades de navegação na Web, baseando-se no modelo Processo de Procura de Varejo pelo Consumidor (CRSP), desenvolvido por Titus e Everett (1995). Mais especificamente, a presente investigação busca verificar se os benefícios derivados da navegação ...

  16. SUPERANDO CONFLITOS NA CONSTRUÇÃO DE UMA PESQUISA COLABORATIVA NA ESCOLA

    OpenAIRE

    Rosa-Silva, Patrícia de Oliveira; Lorencini Júnior, Alvaro

    2007-01-01

    Resumo: Este estudo enfoca a construção de uma parceria na formação continuada de uma professora de Ciências durante o desenvolvimento de uma pesquisa colaborativa. Analisa episódios de resistências e tensões, assim como ações e reações tanto da pesquisadora como da professora que foram capazes de ajustar e superar tais conflitos para consolidar a pesquisa. O processo de formação continuada envolveu uma estratégia de intervenção reflexiva, denominada autoscopia, simulando uma "sala de espelho...

  17. ANOREXIA E BULIMIA NA ADOLESCÊNCIA: EXPRESSÃO DO MAL-ESTAR NA CONTEMPORANEIDADE

    OpenAIRE

    Refosco, Lísia da Luz; Macedo, Mônica Medeiros Kother

    2011-01-01

    A partir de contribuições da Psicanálise apresenta-se uma leitura a respeito dos padecimentos alimentares - anorexia e bulimia - na adolescência como sendo patologias cuja dinâmica permite estabelecer ligações com características e questões dos tempos atuais. Considerando-se a adolescência como um período vital de fragilidade e de vulnerabilidade psíquica, o artigo explora alguns aspectos da sociedade contemporânea, como a cultura da performance, a imposição de ideais de perfeição e completu...

  18. O lugar dos sentimentos na Ciência do Comportamento e na Psicoterapia Comportamental

    OpenAIRE

    Carvalho, Sueli Galego de

    2009-01-01

    Este artigo mostra uma breve reflexão acerca da valorização dos sentimentos no contexto da terapia comportamental. Discute-se também algumas considerações gerais sobre as idéias de Skinner a respeito das explicações mentalistas do comportamento humano, procurando-se analisar teoricamente como os eventos “encobertos” têm sua parcela na determinação dos comportamentos expressos.Palavras-chave: sentimentos, comportamento encoberto, mentalismo, terapia comportamental cognitiva.

  19. ÁREA VERDE NA ESCOLA: UMA EXPLORAÇÃO NA CIDADE DE IMPERATRIZ

    OpenAIRE

    Santos, Gledson Weslley Pereira

    2016-01-01

    O meio ambiente é essencial à vida humana. E o homem, assim como outras espécies, faz parte do meio ambiente. Embora, por parte dos homens, essa relação tenha se mostrado de forma antropocêntrica traz na atualidade o exigente desafio da preservação e sustentabilidade socioambiental. Identifico a escola como uma instituição importante para contribuir no processo de mudar a forma utilitária e gerencial que o homem tem com o meio ambiente. Mas como as escolas estão caminhando para...

  20. Electron scattering in graphene with adsorbed NaCl nanoparticles

    International Nuclear Information System (INIS)

    Drabińska, Aneta; Kaźmierczak, Piotr; Bożek, Rafał; Karpierz, Ewelina; Wysmołek, Andrzej; Kamińska, Maria; Wołoś, Agnieszka; Pasternak, Iwona; Strupiński, Włodek; Krajewska, Aleksandra

    2015-01-01

    In this work, the results of contactless magnetoconductance and Raman spectroscopy measurements performed for a graphene sample after its immersion in NaCl solution were presented. The properties of the immersed sample were compared with those of a non-immersed reference sample. Atomic force microscopy and electron spin resonance experiments confirmed the deposition of NaCl nanoparticles on the graphene surface. A weak localization signal observed using contactless magnetoconductance showed the reduction of the coherence length after NaCl treatment of graphene. Temperature dependence of the coherence length indicated a change from ballistic to diffusive regime in electron transport after NaCl treatment. The main inelastic scattering process was of the electron-electron type but the major reason for the reduction of the coherence length at low temperatures was additional, temperature independent, inelastic scattering. We associate it with spin flip scattering, caused by NaCl nanoparticles present on the graphene surface. Raman spectroscopy showed an increase in the D and D′ bands intensities for graphene after its immersion in NaCl solution. An analysis of the D, D′, and G bands intensities proved that this additional scattering is related to the decoration of vacancies and grain boundaries with NaCl nanoparticles, as well as generation of new on-site defects as a result of the decoration of the graphene surface with NaCl nanoparticles. The observed energy shifts of 2D and G bands indicated that NaCl deposition on the graphene surface did not change carrier concentration, but reduced compressive biaxial strain in the graphene layer

  1. Electron scattering in graphene with adsorbed NaCl nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Drabińska, Aneta, E-mail: Aneta.Drabinska@fuw.edu.pl; Kaźmierczak, Piotr; Bożek, Rafał; Karpierz, Ewelina; Wysmołek, Andrzej; Kamińska, Maria [Faculty of Physics, University of Warsaw, Pasteura 5, 02-093 Warsaw (Poland); Wołoś, Agnieszka [Faculty of Physics, University of Warsaw, Pasteura 5, 02-093 Warsaw (Poland); Institute of Physics, Polish Academy of Sciences, Al. Lotników 32/46, 02-668 Warsaw (Poland); Pasternak, Iwona; Strupiński, Włodek [Institute of Electronic Materials Technology, Wólczyńska 133, 01-919 Warsaw (Poland); Krajewska, Aleksandra [Institute of Electronic Materials Technology, Wólczyńska 133, 01-919 Warsaw (Poland); Institute of Optoelectronics, Military University of Technology, Kaliskiego 2, 00-908 Warsaw (Poland)

    2015-01-07

    In this work, the results of contactless magnetoconductance and Raman spectroscopy measurements performed for a graphene sample after its immersion in NaCl solution were presented. The properties of the immersed sample were compared with those of a non-immersed reference sample. Atomic force microscopy and electron spin resonance experiments confirmed the deposition of NaCl nanoparticles on the graphene surface. A weak localization signal observed using contactless magnetoconductance showed the reduction of the coherence length after NaCl treatment of graphene. Temperature dependence of the coherence length indicated a change from ballistic to diffusive regime in electron transport after NaCl treatment. The main inelastic scattering process was of the electron-electron type but the major reason for the reduction of the coherence length at low temperatures was additional, temperature independent, inelastic scattering. We associate it with spin flip scattering, caused by NaCl nanoparticles present on the graphene surface. Raman spectroscopy showed an increase in the D and D′ bands intensities for graphene after its immersion in NaCl solution. An analysis of the D, D′, and G bands intensities proved that this additional scattering is related to the decoration of vacancies and grain boundaries with NaCl nanoparticles, as well as generation of new on-site defects as a result of the decoration of the graphene surface with NaCl nanoparticles. The observed energy shifts of 2D and G bands indicated that NaCl deposition on the graphene surface did not change carrier concentration, but reduced compressive biaxial strain in the graphene layer.

  2. Effect of chloride substitution on the order–disorder transition in NaBH4 and Na11BD4

    International Nuclear Information System (INIS)

    Olsen, Jørn Eirik; Karen, Pavel; Sørby, Magnus H.; Hauback, Bjørn C.

    2014-01-01

    Graphical abstract: Interactions that order the BD 4 - tetrahedra below the order–disorder transition became increasingly frustrated by the solute in the Na( 11 BD 4 ) 1−x Cl x solid solutions, and the order disappears at x = 0.158. Highlights: • The order–disorder transition temperature for Na(BH 4 ) 1−x Cl x and Na( 11 BD 4 ) 1−x Cl x is highly dependent on the Cl-content, x. • The transition is characterized by DSC for Na( 11 BD 4 ) 1−x Cl x for x = 0, 0.10 and 0.15. • No transition is observed for x ⩾ 0.20 on cooling to 8 K. • The crystal structures are reported for Na 11 BD 4 at room temperature and 8 K and Na( 11 BD 4 ) 1−x Cl x (x = 0.10, 0.15, 0.20 and 0.25) at 8 K from powder neutron diffraction. -- Abstract: Phase transition associated with anion disordering over two orientations in Na 11 BD 4 (NaBH 4 ) and its solid solutions with NaCl, Na( 11 BD 4 ) 1−x Cl x , is investigated with powder diffraction (neutron and synchrotron radiation), differential scanning calorimetry and Raman spectroscopy. Upon heating, the transition temperature extrapolated to zero rate of heating is 192.2 K for Na 11 BD 4 , ΔS = 4.41 J/mol K, hysteresis 1.7 K and the volume increase 0.43%. Thermal parameters of the transition in Na( 11 BD 4 ) 1−x Cl x follow a colligative-property model of an ideal solution, with x = 0.158(1) as the critical concentration at which the ordering interactions and the transition itself are eliminated. On approaching this limit, the tetragonal distortion of the ordered structure decreases somewhat towards the cubic average, and this is associated with a partial disorder of the tetrahedral anions seen by diffraction methods. In fact, a 3% disorder is already present in the pure solvent of the solid solution (Na 11 BD 4 ) at 8 K

  3. Istraživanje uticaja nekih parametara na osetljivost eksplozivnih materija na toplotni impuls / Investigation of the effects of some parameters explosives sensitivity to heat impulse

    OpenAIRE

    Radun Jeremić

    2002-01-01

    Ispitivana je osetljivost nekoliko vrsta eksplozivnih materija na toplotni impuls merenjem vremena zadrške u zavisnosti od temperature. Na osnovu eksperimentalnih rezultata određene su vrednosti energije aktivacije i predeksponencijalni faktori u jednačini Semjonova. Istraživan je i uticaj mase ispitivanog uzorka, granulacije i veličine kristala eksploziva na osetljivost na toplotni impuls. Pokazano je da ovi parametri imaju značajan uticaj na osetljivost eksplozivnih materija, pa je neophodn...

  4. O outro na relação

    Directory of Open Access Journals (Sweden)

    Reinoldo Marquezan

    2012-03-01

    Full Text Available O texto aborda as contribuições de Meirieu em relação ao outro que se estabelece na relação pedagógica e de Maturana que refere o outro como legítimo outro da convivência. Aponta ser necessário estabelecer o outro na relação como legítimo outro para a consecução do ato pedagógica.Palavras-chave: O Outro na Relação. Relação Pedagógica.

  5. As terapias alternativas na assistência de enfermagem

    Directory of Open Access Journals (Sweden)

    Jackçon L. Savi

    1995-12-01

    Full Text Available Na seqüência do acompanhamento da disciplina "Métodos Terapêuticos Alternativos" (MTA. implantada no Curso de Graduação em Enfermagem da UFSC em 1990. focalizou-se os egressos com o objetivo de verificar a utilização das terapias alternativas na assistência de enfermagem que prestam como enfermeiros. Nenhum dos entrevistados posicionou-se contrário e a maioria confirmou utilizar uma ou mais terapias na assistência que prestam aos usuários dos serviços onde atuam.

  6. Personalidades vocacionais e processos de carreira na vida adulta

    OpenAIRE

    Magalhães, Mauro de Oliveira; Gomes, William B.

    2007-01-01

    Esta pesquisa abordou a relação entre interesses vocacionais e os processos de comprometimento e entrincheiramento na carreira em diferentes fases da vida. Uma amostra de 733 profissionais (415 homens e 318 mulheres) respondeu a medidas de comprometimento e de entrincheiramento na carreira. Os sujeitos foram categorizados de acordo com o interesse vocacional predominante na tipologia de Holland. As análises revelaram interação entre estágio de vida e personalidade vocacional para os escores d...

  7. OMREŽNA VARNOST Z UPORABO IPSEC IN VPN

    OpenAIRE

    Jelušič, Miran

    2011-01-01

    Diplomska naloga podaja osnovno razumevanje IPsec VPN protokolov, ki nudijo varno povezavo prek interneta. Predstavi, kako se na Cisco usmerjevalnikih postavi IPsec povezava med vozliščema, za katero uporabimo Cisco IOS ukaze v konzolnem načinu. V nadaljevanju prikaže, kako s pomočjo Cisco programa Security Device Manager postavimo IPsec VPN povezavo med vozliščema in uporabimo »Easy VPN« strežnik. Cisco SDM deluje v grafičnem načinu in omogoča konfiguriranje s pomočjo čarovnika. Če je potreb...

  8. VPLIV VAN DER WAALSOVIH SIL NA TVORBO ASOCIIRANIH MOLEKUL

    OpenAIRE

    Kuster, Bernarda

    2014-01-01

    Namen diplomske naloge je preučiti vpliv van der Waalsovih sil na tvorbo asociiranih molekul. V ta namen smo izbrali površinsko aktivne snovi, ki imajo amfifilne lastnosti in vplivajo na povšinske in medfazne napetosti ter pri določeni koncentraciji, imenovani kritična micelna koncentracija (CMC), tvorijo molekulske skupke, ki jim pravimo micele. Kritično micelno koncentracijo smo določili trem površinsko aktivnim snovem: heksadeciltrimetilamonijevemu bromidu, tetradeciltrimetilamonijevemu b...

  9. A presença de Francis Bacon na Enciclopedia

    OpenAIRE

    Bruna Torlay Pires

    2008-01-01

    Resumo: Este trabalho procura assinalar traços da filosofia de Francis Bacon na Enciclopédia francesa do século XVIII. Estes traços se manifestam nas teses que defendem o intercurso entre avanço técnico e progresso do conhecimento, e o ideal de ciência como conquista indefinida que escapa ao gênio individual, e sobrevive como patrimônio comum da humanidade. Compreensivamente, mostra que o utilitarismo? de Francis Bacon e dos enciclopedistas na verdade se fundamenta na idéia capital de que a e...

  10. Fluorine-18 NaF PET imaging of child abuse

    Energy Technology Data Exchange (ETDEWEB)

    Drubach, Laura A. [Children' s Hospital Boston and Harvard Medical School, Department of Radiology, Division of Nuclear Medicine/PET, Boston, MA (United States); Sapp, Mark.V. [School of Osteopathic Medicine, Child Abuse Research Education and Services (CARES) Institute University of Medicine and Dentistry of New Jersey, New Jersey (United States); Laffin, Stephen [Children' s Hospital Boston, Department of Radiology, Division of Nuclear Medicine/PET, Boston, MA (United States); Kleinman, Paul K. [Children' s Hospital Boston and Harvard Medical School, Department of Radiology, Division of Musculoskeletal Imaging, Boston, MA (United States)

    2008-07-15

    We describe the use of {sup 18}F-NaF positron emission tomography (PET) whole-body imaging for the evaluation of skeletal trauma in a case of suspected child abuse. To our knowledge, 18F NaF PET has not been used in the past for the evaluation of child abuse. In our patient, this technique detected all sites of trauma shown by initial and follow-up skeletal surveys, including bilateral metaphyseal fractures of the proximal humeri. Fluorine-18 NaF PET has potential advantage over Tc-99m-labeled methylene diphosphonate (MDP) based upon superior image contrast and spatial resolution. (orig.)

  11. Os contos de fadas na alfabetização

    Directory of Open Access Journals (Sweden)

    Glória Radino

    2017-03-01

    Full Text Available Partindo de alguns trabalhos que utilizam os contos de fadas na alfabetização, o artigo discute as possibilidades do professor acolher a fantasia infantil como um importante aspecto do desenvolvimento. Mais do que a utilização dos contos de fadas na educação, trata-se de questionar a forma como a infância é percebida. A forma como os contos de fadas são utilizados na alfabetização está diretamente relacionada à concepção de infância que permeia o discurso pedagógico.

  12. Ensaio sobre desenvolvimento humano na pós-modernidade

    OpenAIRE

    Abib,José Antônio Damásio

    2008-01-01

    Neste ensaio, o conceito de desenvolvimento humano na pós-modernidade apóia-se em uma filosofia pós-moderna de direitos humanos, e na modernidade apóia-se em uma filosofia moderna de direitos humanos. O Estado moderno fracassou na realização da filosofia moderna dos direitos humanos. Uma filosofia pós-moderna de direitos humanos deixa para trás a filosofia moderna de direitos humanos. Isso significa abandonar o fundacionismo ético e as grandes narrativas emancipatórias de desenvolvimento huma...

  13. Polimorfismo na produção de medicamentos

    Directory of Open Access Journals (Sweden)

    Gabriel Lima Barros de Araujo

    2012-01-01

    Full Text Available O polimorfismo pode ocasionar desvios de qualidade durante o processo produtivo e influenciar o desempenho dos medicamentos. Por isso, o entendimento do fenômeno e suas implicações abre um campo amplo de possibilidades a serem exploradas na área farmacêutica, incluindo o surgimento de novos paradigmas e ferramentas na garantia da qualidade de medicamentos. Este trabalho apresenta uma introdução aos aspectos básicos do fenômeno do polimorfismo e suas implicações na produção e controle de medicamentos, com ênfase no polimorfismo dos fármacos.

  14. Fluorine-18 NaF PET imaging of child abuse

    International Nuclear Information System (INIS)

    Drubach, Laura A.; Sapp, Mark V.; Laffin, Stephen; Kleinman, Paul K.

    2008-01-01

    We describe the use of 18 F-NaF positron emission tomography (PET) whole-body imaging for the evaluation of skeletal trauma in a case of suspected child abuse. To our knowledge, 18F NaF PET has not been used in the past for the evaluation of child abuse. In our patient, this technique detected all sites of trauma shown by initial and follow-up skeletal surveys, including bilateral metaphyseal fractures of the proximal humeri. Fluorine-18 NaF PET has potential advantage over Tc-99m-labeled methylene diphosphonate (MDP) based upon superior image contrast and spatial resolution. (orig.)

  15. As terapias alternativas na assistência de enfermagem

    Directory of Open Access Journals (Sweden)

    Jackçon L. Savi

    Full Text Available Na seqüência do acompanhamento da disciplina "Métodos Terapêuticos Alternativos" (MTA. implantada no Curso de Graduação em Enfermagem da UFSC em 1990. focalizou-se os egressos com o objetivo de verificar a utilização das terapias alternativas na assistência de enfermagem que prestam como enfermeiros. Nenhum dos entrevistados posicionou-se contrário e a maioria confirmou utilizar uma ou mais terapias na assistência que prestam aos usuários dos serviços onde atuam.

  16. BIODISPONIBILIDADE DE FERRO NA MERENDA ESCOLAR

    Directory of Open Access Journals (Sweden)

    PATRíCIA DA SILVA GOLDSCHMIDT

    2009-06-01

    Full Text Available

    Uma alimentação inadequada durante o período escolar resulta em alterações do aprendizado, da atenção e em carências nutricionais. Portanto, este trabalho teve como objetivo estimar a biodisponibilidade do ferro ingerido durante o período escolar, no Instituto Estadual de Educação Ernesto Alves, da cidade de Rio Pardo-RS, em escolares de 7 a 14 anos, seguindo a determinação do Programa Nacional de Alimentação Escolar (PNAE, ou seja, 15% do Valor Energético Total (VET diário, por faixa etária, através da identificação das quantidades de cálcio (fator inibidor e vitamina C (fator facilitador, considerando que ambos interferem na biodisponibilidade do ferro no organismo humano, para tanto, seguiu-se a metodologia de Fausto15 e Coelho.11 Os resultados deste estudo mostram, em 59% dos dias, valores insuficientes de ferro total biodisponível, ingeridos durante o período escolar, devido as quantidades baixas de vitamina C (91% dos dias, e elevadas de Cálcio (32% dos dias.

  17. Epidemiologia da raiva humana na Guanabara

    Directory of Open Access Journals (Sweden)

    Alfredo R. Matta B. da Silva

    1971-08-01

    Full Text Available A raiva humana se mantém como problema de Saúde Pública, especialmente nas áreas urbanas, onde o cão atua como principal reservatório e fonte imediata de infecção. A deficiência de programas de controle de cães vadios, de imunização sistemática e de educação sanitária, contribui para a perpetuação da cadeia epidemiológioa. O presente estudo analisa todos os casos de raiva humana, observados em habitantes do Estado da Guanabara, no período 1965-1969, segundo as variáveis: idade, sexo, côr, variação estacional, período de incubação e de duração da fase clínica, fonte de infecção, local de mordedura e uso de vacina posterior à exposição. Os principais resultados foram: 1. A ravia na Guanabara, parece ser mais comum nos grupos etários mais jovens e nos homens. 2. Não se observou variação estacional. 3. O período de incubação mediano foi de 45 dias e de duração da fase clínica de 3 dias. 4. Ocorreu uma associação entre período de incubação menor e vacinação incompleta.

  18. Contratos na pintura: o caso de Volpi

    Directory of Open Access Journals (Sweden)

    Moema Martins Rebouças

    2008-11-01

    Full Text Available Tendo como fundamento a semiótica discursiva, discutiremos as estratégias de manipulação empregadas entre um enunciador e um enunciatário, que definem um contrato na pintura. A semiótica ao considerar a pintura como um texto, quando este trata da semelhança com o mundo natural, pressupõe a instalação de um contrato entre enunciador e enunciatário tendo como base um saber do enunciatário sobre o que este considera ser a "realidade" persuadido por um enunciador que o "faz-crer" do "parecido" da pintura com o mundo natural. Realizações deste tipo são chamadas de iconização, queé o "fazer parecer real" assumido pelo ní­vel figurativo de uma obra, não se restringindo, portanto, aos textos imagéticos, mas a todos os textos que produzem efeito de realidade.Abstract: Having as base the discursive semiotcs, we shall discuss the strategies of manipulation used between a pronouncer and a speaker that define an agreement in the painting. The semiotics considering the painting as a text when this one treats thelikeness with the natural world presuppose the installation of an agreement between a pronouncer and a speaker having as base a knowledge of the speaker about what this one deems to be the persuaded "reality" by a pronouncer that makes him "believe" inthe "likeness" of the painting with the natural world. These types of accomplishments are called iconization, that is to "make something look like real", assumed by the figurative level of a work not restricting, therefore to the texts with icons, but for allthe texts that produce a real effect at the painting the creation of effects with a real effect with a real sense.

  19. Borehole sealing with highly compactd Na bentonite

    International Nuclear Information System (INIS)

    Pusch, R.

    1981-12-01

    This report describes the use of highly compacted Na bentonite for borehole plugging. Bentonites have an extremely low permeability and a low diffusivity, and a swelling ability which produces a nonleaching boundary between clay and rock if the initial bulk density of the bentonite is sufficiently high. The suggested technique, which is applicable to long vertical, and inclined, as well as horizontal boreholes, is based on the use of perforated copper pipes to insert elements of compacted bentonite. Such pipe segments are connected at the rock surface and successively inserted in the hole. When the hole is equipped, the clay takes up water spontaneously and swells through the perforation, and ultimately forms an almost completely homogenous clay core. It embeds the pipe which is left in the hole. Several tests were conducted in the laboratory and one field test was run in Stripa. They all showed that a gel soon fills the slot between the pipe and the confinement which had the form of metal pipes in the laboratory investigations. Subsequently, more clay migrates through the perforation and produces a stiff clay filling in the slot. The redistribution of minerals, leading ultimately to a high degree of homogeneity, can be described as a diffusion process. The rate of redistribution depends on the joint geometry and water flow pattern in the rock. In the rock with an average joint frequence of one per meter or higher, very good homogeneity and sealing ability of the clay are expected within a few months after the application of the plug. (author)

  20. O Perfume ou o Ignorado na Cultura

    Directory of Open Access Journals (Sweden)

    Márcio Boaventura Jr.

    2011-05-01

    Full Text Available

    Resumo: A proposta do artigo é analisar o filme “Perfume, a história de um assassino” de Tom Tykwer sob o ponto de vista da psicanálise e da educação. Para tanto, buscamos debater o mal-estar na cultura, especialmente suas manifestações nas salas de aula, a partir dos diversos pontos do enredo em que podemos ilustrar o que Freud argumentou em sua tese sobre o tema.

     

    Resume: This article is intended to analyze Tom Tykwer's film Perfume: The Story of a Mur-derer (2006 under an educational and psychoanalytical perspective. Therefore we try to question cultural discontentment, mostly its manifestations in class, depicting the plot's many points of view to illustrate Freud thesis' arguing on the subject.

     

  1. A publicidade na perspectiva de Baudrillard

    Directory of Open Access Journals (Sweden)

    Maria Ogécia Drigo

    2009-09-01

    Full Text Available Resumo O propósito deste artigo é apresentar as idéias de Baudrillard sobre publicidade, tratadas na obra O sistema dos objetos. Assim, discutem-se os conceitos de arranjo e de ambiência que culminam no conceito de funcionalidade, os quais permitem apresentar as relações que se estabelecem entre os seres humanos, e entre eles e os objetos. Em seguida, aborda-se o papel da publicidade em meio a esses objetos/signos. Palavras-chave: Jean Baudrillard; comunicação; publicidade; funcionalidade; objetos/signos. Resumen El propósito de este artículo es presentar las ideas de Baudrillard sobre la publicidad, que constan en la obra El sistema de los objetos. Se discuten los conceptos de arreglo y de ambiencia que culminan en el concepto de funcionalidad, los cuales permiten presentar las relaciones que se establecen entre los seres humanos y entre ellos y los objetos. En seguida,se aborda el papel de la publicidad en medio de esos objetos/signos. Palabras-clave: Jean Baudrillard; comunicación; publicidad; funcionalidad; objetos/signos. Abstract This article intends to present Baudrillard’s ideas about advertising as considered in “Le système des objects”, his first book. The concepts of settlement, ambience and functionality are discussed. They make it possible to present the relations constructed among human beings and among humans and objects. We then discuss the role of advertising amongst these objects/signs. Keywords: Jean Baudrillard; communication; advertising; functionality; objects/signs.

  2. Educacão infantil na Noruega

    Directory of Open Access Journals (Sweden)

    Eulina da Rocha Lordelo

    Full Text Available Em comparação com os demais países nórdicos, a Noruega tem uma história mais recente de educação infantil. Um sistema disseminado e com forte financiamento público só se tornou disponível a partir dos anos 70. A descrição desse sistema de educação infantil contida neste artigo inclui um breve histórico, informações sobre financiamento, responsabilidades e custos, disposições legais sobre pessoal - formação necessária e condições de trabalho, bem como instalações, equipamentos e materiais. Todo o sistema é regulado por legislação nacional, preservando ampla liberdade de planejamento e ação para as próprias instituições e o pessoal envolvido. Os objetivos e metas, conteúdos e métodos, a pedagogia como idéias sustentadas e práticas assumidas constituem o foco central do artigo, especialmente a ênfase dedicada à brincadeira e ao trabalho criativo. Acompanhando o relato, o artigo propõe algumas comparações com a situação brasileira, enfatizando as diferenças legais, culturais e pedagógicas que podem ser observadas nos dois sistemas, buscando-se refletir sobre lições que podem ser extraídas e usadas na avaliação do sistema de educação infantil no Brasil.

  3. A Amazônia na Rio+20: as discussões sobre florestas na esfera internacional e seu papel na Rio+20

    Directory of Open Access Journals (Sweden)

    Joana Bezerra

    Full Text Available As florestas apresentam uma situação única e muitas vezes contraditória na esfera internacional. Tema transversal, inerente às principais discussões ambientais e sociais atuais, o regime de florestas não apresenta um documento internacional de leis vinculativas. A situação do tema na Rio+20 também foi contraditória, já que apesar de perpassar os temas discutidos, as florestas não fizeram parte da agenda oficial do evento. No entanto, o momento de mudanças vivido no Brasil contribuiu para que o tema, em particular a Amazônia, fosse exaustivamente discutido em eventos paralelos. Quatro questões dominaram o debate - a construção de Belo Monte, o desmatamento, as unidades de conservação e o código florestal - evidenciando o papel central da Amazônia não apenas no Brasil, mas também na esfera internacional. O objetivo deste artigo é apresentar uma análise dessa qualidade singular do tema florestas na agenda ambiental internacional e o papel da Amazônia no encontro das Nações Unidas.

  4. Active ion transport in the renal proximal tubule. II. Ionic dependence of the Na pump

    OpenAIRE

    1984-01-01

    The dependence of Na pump activity on intracellular and extracellular Na+ and K+ was investigated using a suspension of rabbit cortical tubules that contained mostly (86%) proximal tubules. The ouabain- sensitive rate of respiration (QO2) was used to measure the Na pump activity of intact tubules, and the Na,K-ATPase hydrolytic activity was measured using lysed proximal tubule membranes. The dependence (K0.5) of the Na pump on intracellular Na+ was affected by the relative intracellular conce...

  5. Magnetic and structural properties of NaLnMnWO6 and NaLnMgWO6 perovskites

    International Nuclear Information System (INIS)

    King, Graham; Wayman, Lora M.; Woodward, Patrick M.

    2009-01-01

    We have prepared 14 new AA'BB'O 6 perovskites which possess a rock salt ordering of the B-site cations and a layered ordering of the A-site cations. The compositions obtained are NaLnMnWO 6 (Ln=Ce, Pr, Sm, Gd, Dy, and Ho) and NaLnMgWO 6 (Ln=Ce, Pr, Sm, Eu, Gd, Tb, Dy, and Ho). The samples were structurally characterized by powder X-ray diffraction which has revealed metrically tetragonal lattice parameters for compositions with Ln=Ce, Pr and monoclinic symmetry for compositions with smaller lanthanides. Magnetic susceptibility vs. temperature measurements have found that all six NaLnMnWO 6 compounds undergo antiferromagnetic ordering at temperatures between 10 and 13 K. Several compounds show signs of a second magnetic phase transition. One sample, NaPrMnWO 6 , appears to pass through at least three magnetic phase transitions within a narrow temperature range. All eight NaLnMgWO 6 compounds remain paramagnetic down to 2 K revealing that the ordering of the Ln 3+ cations in the NaLnMnWO 6 compounds is induced by the ordering of the Mn 2+ sub-lattice. - Graphical abstract: Evidence for multiple magnetic phase transitions in the A and B-site ordered perovskite NaPrMnWO 6 .

  6. Encapsulation of Metallic Na in an Electrically Conductive Host with Porous Channels as a Highly Stable Na Metal Anode.

    Science.gov (United States)

    Luo, Wei; Zhang, Ying; Xu, Shaomao; Dai, Jiaqi; Hitz, Emily; Li, Yiju; Yang, Chunpeng; Chen, Chaoji; Liu, Boyang; Hu, Liangbing

    2017-06-14

    Room-temperature Na ion batteries (NIBs) have attracted great attention because of the widely available, abundant sodium resources and potentially low cost. Currently, the challenge of the NIB development is due primarily to the lack of a high-performance anode, while the Na metal anode holds great promise considering its highest specific capacity of 1165 mA h/g and lowest anodic potential. However, an uneven deposit, relatively infinite volume change, and dendritic growth upon plating/stripping cycles cause a low Coulombic efficiency, poor cycling performance, and severe safety concerns. Here, a stable Na carbonized wood (Na-wood) composite anode was fabricated via a rapid melt infusion (about 5 s) into channels of carbonized wood by capillary action. The channels function as a high-surface-area, conductive, mechanically stable skeleton, which lowers the effective current density, ensures a uniform Na nucleation, and restricts the volume change over cycles. As a result, the Na-wood composite anode exhibited flat plating/stripping profiles with smaller overpotentials and stable cycling performance over 500 h at 1.0 mA/cm 2 in a common carbonate electrolyte system. In sharp comparison, the planar Na metal electrode showed a much shorter cycle life of 100 h under the same test conditions.

  7. 23 Na and 17O NMR studies of hyperkagome Na4Ir3O8

    Science.gov (United States)

    Shockley, Abigail; Bert, Fabrice; Orain, Jean-Christophe; Okamoto, Yoshihiko; Mendels, Philippe

    2015-03-01

    Na4Ir3O8 is a unique case of a 3D corner sharing triangular lattice which can be decorated with quantum spins. It has spurred a lot of theoretical interest as a spin liquid candidate of a new kind where the Hamiltonian might not be thought in terms of a simple Heisenberg case because of spin orbit coupling on the Ir 5d element. We present a comprehensive set of NMR data taken on both the 23Na and 17O sites. We have found that magnetic freezing of all Ir sites sets in below Tf ~ 7.5K ~ 0 . 019 J with a clear hyperfine field transferred from Ir moments and a drastic decrease of 1 /T1 . Above Tf, physical properties are expected to be a landmark of frustration in this exotic geometry. We will discuss our shift and relaxation data in the temperature range of 300K to 7.5 K in the light of published thermodynamic measurements (Y. Okamotoa et al, PRL 99 137207, 2007 and Y. Singh et al, PRB 88 220413(R), 2013) and comment on their implications for the already existing large body of theoretical work.

  8. O direito natural na idade moderna e a filosofia do contrato social na obra de Rousseau

    Directory of Open Access Journals (Sweden)

    João Gabriel Laprovitera Rocha

    2012-06-01

    Full Text Available O estudo parte de uma análise do jusnaturalismo na Idade Moderna e de seu esforço no sentido de oferecer uma fundamentação racional (e não mais transcendental para a existência dos direitos naturais do homem. Em seguida, passa-se a uma reavaliação dos pilares da teoria contratualista que ressurgiu vigorosamente nas teses iluministas daquele período, notadamente no pensamento de Rousseau. Nesse sentido, revisitam-se os inovadores conceitos de soberania popular e vontade geral, para, ato contínuo, confrontá-los com a crítica impiedosa e sugerir o verdadeiro objetivo intentado pelo filósofo genebrês em seu texto. Ao final, conclui-se pela influência salutar da obra rousseauniana no florescer da Revolução Francesa, de 1789, e pela persistência e atualidade dos seus princípios que, se bem contextualizados, podem auxiliar no processo de aprimoramento do modelo de democracia representativa presente nas nações mais influentes do mundo contemporâneo.

  9. FATORES DE RISCO NA REPETIÇÃO DE GRAVIDEZ NA ADOLESCÊNCIA

    Directory of Open Access Journals (Sweden)

    Eulália Maria Chaves-Maia

    2009-01-01

    Full Text Available A fim de traçar o perfil biopsicossocial de adolescentes com repetição de gravidez e seus fatores associados, investigou-se questões socio-demográficas, variáveis biológicas e psicológicas de 50 adolescentes multigestas.Os dados analisados através de estatística descritiva apontam que a maioria das adolescentes não frequentava a escola e vivia em união estável, que 54% não fez uso de métodos contraceptivos na primeira relação sexual e 88% nunca participou dos programas de Planejamento Familiar. Assim, políticas públicas de educação sexual e reprodutiva devem identificar comportamentos sexuais de risco, atuar na construção de valores familiares e no planejamento das gestações.

  10. Distinct pH dependencies of Na+/K+ selectivity at the two faces of Na,K-ATPase.

    Science.gov (United States)

    Cornelius, Flemming; Tsunekawa, Naoki; Toyoshima, Chikashi

    2018-02-09

    The sodium pump (Na,K-ATPase) in animal cells is vital for actively maintaining ATP hydrolysis-powered Na + and K + electrochemical gradients across the cell membrane. These ion gradients drive co- and countertransport and are critical for establishing the membrane potential. It has been an enigma how Na,K-ATPase discriminates between Na + and K + , despite the pumped ion on each side being at a lower concentration than the other ion. Recent crystal structures of analogs of the intermediate conformations E2·Pi·2K + and Na + -bound E1∼P·ADP suggest that the dimensions of the respective binding sites in Na,K-ATPase are crucial in determining its selectivity. Here, we found that the selectivity at each membrane face is pH-dependent and that this dependence is unique for each face. Most notable was a strong increase in the specific affinity for K + at the extracellular face ( i.e. E2 conformation) as the pH is lowered from 7.5 to 5. We also observed a smaller increase in affinity for K + on the cytoplasmic side (E1 conformation), which reduced the selectivity for Na + Theoretical analysis of the p K a values of ion-coordinating acidic amino acid residues suggested that the face-specific pH dependences and Na + /K + selectivities may arise from the protonation or ionization of key residues. The increase in K + selectivity at low pH on the cytoplasmic face, for instance, appeared to be associated with Asp 808 protonation. We conclude that changes in the ionization state of coordinating residues in Na,K-ATPase could contribute to altering face-specific ion selectivity. © 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

  11. Down-Regulation of the Na+-Coupled Phosphate Transporter NaPi-IIa by AMP-Activated Protein Kinase

    Directory of Open Access Journals (Sweden)

    Miribane Dërmaku-Sopjani

    2013-11-01

    Full Text Available Background/Aims: The Na+-coupled phosphate transporter NaPi-IIa is the main carrier accomplishing renal tubular phosphate reabsorption. It is driven by the electrochemical Na+ gradient across the apical cell membrane, which is maintained by Na+ extrusion across the basolateral cell membrane through the Na+/K+ ATPase. The operation of NaPi-IIa thus requires energy in order to avoid cellular Na+ accumulation and K+ loss with eventual decrease of cell membrane potential, Cl- entry and cell swelling. Upon energy depletion, early inhibition of Na+-coupled transport processes may delay cell swelling and thus foster cell survival. Energy depletion is sensed by the AMP-activated protein kinase (AMPK, a serine/threonine kinase stimulating several cellular mechanisms increasing energy production and limiting energy utilization. The present study explored whether AMPK influences the activity of NAPi-IIa. Methods: cRNA encoding NAPi-IIa was injected into Xenopus oocytes with or without additional expression of wild-type AMPK (AMPKα1-HA+AMPKβ1-Flag+AMPKγ1-HA, of inactive AMPKαK45R (AMPKα1K45R+AMPKβ1-Flag+AMPKγ1-HA or of constitutively active AMPKγR70Q (AMPKα1-HA+AMPKβ1-Flag+AMPKγ1R70Q. NaPi-IIa activity was estimated from phosphate-induced current in dual electrode voltage clamp experiments. Results: In NaPi-IIa-expressing, but not in water-injected Xenopus oocytes, the addition of phosphate (1 mM to the extracellular bath solution generated a current (Ip, which was significantly decreased by coexpression of wild-type AMPK and of AMPKγR70Q but not of AMPKαK45R. The phosphate-induced current in NaPi-IIa- and AMPK-expressing Xenopus ooocytes was significantly increased by AMPK inhibitor Compound C (20 µM. Kinetic analysis revealed that AMPK significantly decreased the maximal transport rate. Conclusion: The AMP-activated protein kinase AMPK is a powerful regulator of NaPi-IIa and thus of renal tubular phosphate transport.

  12. O narcotráfico na Ásia Central

    OpenAIRE

    Nunes, Rui

    2003-01-01

    O Afeganistão é um dos maiores produtores de ópio do mundo, dando origem a cerca de 75% da heroína consumida à escala mundial. A maioria dos consumidores desta substância concentra-se nas imediações deste país – metade da produção é consumida no Paquistão, no Irão, na Rússia e em antigos países da CEI. A quase totalidade da heroína consumida na Europa (90%) tem origem afegã. No entanto têm sido implementadas medidas tendentes ao endurecimento do combate à droga no Irão, a grande “porta de saí...

  13. Vstop podjetja na slovenski trg s podružnico

    OpenAIRE

    Božič, Kim

    2017-01-01

    V današnjem poslovnem svetu je za podjetje zelo pomembno, če ne celo nujno, da se posvečajo globalnim trgom. Če podjetnik želi, da njegovo podjetje raste in se razvija, mora razmišljati o globalizaciji oziroma o širjenju poslovanja izven meja svoje države, za kar pa lahko uporabi enega od številnih možnih načinov vstopa na tuj trg. Ker se ti načini med seboj razlikujejo, mora poznati vse značilnosti, omejitve ter prednosti in slabosti posameznih načinov, saj se lahko le tako odloči, s katerim...

  14. Talinvesti hiigelkahju täna kohtus arutusel / Kristina Traks

    Index Scriptorium Estoniae

    Traks, Kristina, 1976-

    2001-01-01

    na tuleb Tallinna linnakohtus arutusele mullu pankrotistunud investeerimispanga Talinvest, nüüdse nimega TB Holding pankrotihalduri kaebus ettevõtte omanike ja juhtide vastu 81 miljoni kroonise kahju tekitamises

  15. Sobre a afetividade na odontologia para bebês

    Directory of Open Access Journals (Sweden)

    Ricardo Azevedo Barreto

    Full Text Available Este artigo é uma síntese da dissertação de mestrado “A afetividade na Odontologia para bebês: lugares e nuances”, defendida na Universidade de São Paulo. A partir da perspectiva teórica de Guirado (1986 e 1987, com a colaboração de três odontopediatras, investigou-se a afetividade na Odontologia para bebês por meio de análise de representações de verbalizações das dentistas em vinte sessões clínicas e entrevistas individualizadas. Depreenderam-se, deste estudo, temáticas específicas, como a indiferenciação profissional-paciente e as possibilidades de transformação nas relações na área pesquisada.

  16. Primena swot analize na sistem integralnog transporta Vojske Srbije

    OpenAIRE

    Dragan Pamučar

    2008-01-01

    U radu je prikazana primena SWOT analize na sistem integralnog transporta Vojske Srbije. Kao rezultat analize predstavljeni su ciljevi daljeg usavršavanja integralnog transporta, kao i mogući problemi generisani strateškim upravljanjem.

  17. Na2MoO2As2O7

    Directory of Open Access Journals (Sweden)

    Raja Jouini

    2012-12-01

    Full Text Available Disodium molybdenum dioxide diarsenate, Na2MoO2As2O7, has been synthesized by a solid-state reaction. The structure is built up from MoAs2O12 linear units sharing corners to form a three-dimensional framework containing tunnels running along the a-axis direction in which the Na+ cations are located. In this framework, the AsV atoms are tetrahedrally coordinated and form an As2O7 group. The MoVI atom is displaced from the center of an octahedron of O atoms. Two Na+ cations are disordered about inversion centres. Structural relationships between different compounds: A2MoO2As2O7 (A = K, Rb, AMOP2O7 (A = Na, K, Rb; M = Mo, Nb and MoP2O7 are discussed.

  18. Fiebre del oro blanco: la cocaína

    Directory of Open Access Journals (Sweden)

    Iván Marín Argüello

    1999-12-01

    Full Text Available La planta de coca, Erythroxylon coca es cultivada en la zona occidental de América del Sur exigiendo condiciones de suelo muy particulares. La mezcla de las hojas de cocaína con sustancias químicas origina un polvo cristalino blanco, conocido comúnmente como cocaína. Al producto obtenido del tratamiento de la cocaína con solventes se le denomina crack. El consumo de cocaína, las formas de administración más diversas y el estado fisiológico logrado por los usuarios, es denominado flash 0 high Los efectos neuro-fisiológicos son muy variados, provocando sobre todo un fuerte estímulo al Sistema Nervioso Central (SNC, producto de la liberación de dopamina en las terminaciones nerviosas.

  19. Lattice sites of Na dopants in ZnO

    CERN Document Server

    AUTHOR|(CDS)2069243; Martins Correia, Joao; Amorim, Lígia; Decoster, Stefan; Ribeiro da Silva, Manuel; Da Costa Pereira, Lino Miguel

    2016-01-01

    The angular distribution of beta− particles emitted by the radioactive isotope 24Na was monitored following implantation into ZnO single crystals at fluences above 5E12 cm−2 at CERN’s ISOLDE facility. We identified sodium on two distinct sites: on substitutional Zn sites and on interstitial sites that are close to the so-called octahedral site. The interstitial Na was to large extent converted to substitutional Na already for annealing at 200°C, from which an activation energy of 0.8−1.3 eV, most likely around 1.2 eV, is estimated for the migration of interstitial Na in ZnO.

  20. (IMobilidade na cidade de São Paulo

    Directory of Open Access Journals (Sweden)

    Raquel Rolnik

    2011-04-01

    Full Text Available O trabalho procura deslindar a crise da mobilidade que a metrópole paulistana tem vivido na última década. Para tanto, apresenta uma análise crítica acerca dos projetos de mobilidade que foram implantados historicamente na cidade de São Paulo, focalizando em particular os investimentos e as mudanças na gestão realizados pelos poderes públicos municipal e estadual em infraestrutura viária e transporte coletivo na última década.This paper seeks to understand the mobility crisis lived by São Paulo in the last decade. The study presents a historical and critical analysis of the mobility projects which has been implemented in the city, with particular focus on the investments and projects implemented by state and local governments in road infrastructure and public transportation in the last decade.

  1. 2018 NA62 Status Report to the CERN SPSC

    CERN Document Server

    NA62, Collaboration

    2018-01-01

    The status of the NA62 experiment is reported. The ongoing activities on detectors and hardware are summarised and the status of the data processing is reviewed. The result from the "K^{+}\\rightarrow\\pi^{+}\

  2. ondersoek na besmetlike aandoenings met stremmende invloed op ...

    African Journals Online (AJOL)

    Coronavirus. +++. IBR/IPV. ++. ++. +. Parainfluenza. +. +. Slenkdalkoors. ++. ++. Bloutong. +. +. Ondersoeke na besmetlike oorsake van neonatale vrektes by kalwers. A. Aantal bedrywe. I. Geslote kuddes. 33. 2. Vetmestingseenhede. 19. B. Aantal kalwers vir gedetailleerde ondersoeke verwerk. I. Hebdomadale periode. 93.

  3. Vpliv transmaščobnih kislin na zdravje

    OpenAIRE

    Pavlin, Teja

    2017-01-01

    Uvod: Maščobe so vsakodnevno prisotne v naši prehrani. Pomembno za nas je, da znamo pravilno uskladiti razmerje med maščobami, ki naše zdravje varujejo in tistimi, ki nam škodujejo. Med slednje spadajo transmaščobne kisline, ki imajo dokazano negativen učinek na zdravje. Namen: Namen diplomskega dela je predstaviti, kakšen je vpliv TMK na zdravje. Želimo predstaviti, kje v prehrani so transmaščobne kisline prisotne in katera so najpogostejša živila s transmaščobnimi kislinami. Namen dela je t...

  4. Phase transitions in Na2TeO4 ceramics

    Indian Academy of Sciences (India)

    low temperature (600°C). X-ray powder diffraction (XRD) technique was used to check the formation of single phase NaTeO4 compound with cell parameters a = 10·602(1) Å; ... nique in an air atmosphere with raw materials Na2Co3. (AR grade 99·9% M/s S.D. Fine Chem, India) and TeO2. (99% M/s Aldrich Chemical Co.

  5. Page 1 OMUMŲ OMENALA IGBO NA NGALABA GS NKE ...

    African Journals Online (AJOL)

    JONATHAN

    N' [kwado nke a, Fafunwa (197. Agbxrx qbxla n'agbanyghſ etu ha ha ibu nwere usoro ha si azxlite ma na akxziri xmxntak[r[ ha na nd[ ntorob[a ha ihe, izxlite xmxaka n'obibi ndx d[ ara ya anagh[ abx otu n'agbxrx niile. Nkowa Omenala: E nwere ike ikowa omenala n'uzo dį iche iche. Nke a bų ufodụ nkowa ndị mmadụ nyere.

  6. Stambene zgrade arhitekta Frane Gotovca na Spinutu u Splitu

    OpenAIRE

    Perković Jović, Vesna

    2010-01-01

    Članak analizira zgrade arhitekta Frane Gotovca podignute 1970.-1980. godine na sjevernom dijelu Spinuta. Tim je zgradama Gotovac učinio bitan otklon u oblikovanju zgrada kolektivnog stanovanja velikog volumena u odnosu na tadašnju uobičajenu projektantsku praksu. Gotovac je pridonio organizaciji i urbanističkom oblikovanju stambenih naselja visoke gustoće stanovanja u usporedbi s naseljima toga vremena.

  7. Pornografia infantil na Internet: violência sexual ou pornografia?

    Directory of Open Access Journals (Sweden)

    Tatiana Savoia Landini

    2000-01-01

    Full Text Available O artigo versa sobre a proliferação da pornografia infantil na internet. Argumento que uma possível explicação para o aumento dessa troca seja o não entendimento, por parte dos internautas, de que a pornografia infantil é uma forma de violência sexual contra a criança. Essa visão é engendrada pela especificidades da troca desse tipo de material na rede.

  8. IDENTIDADE SEXUAL NA FICÇÃO TELEVISIVA

    Directory of Open Access Journals (Sweden)

    Fernanda Castilho Santana

    2009-06-01

    Full Text Available objetivo com este artigo é definir alguns pontos de discussão relacionados à abordagem do tema "homossexualismo feminino" na ficção televisiva brasileira. A reflexão proporciona observações a respeito das tendências de mudança no tratamento do assunto na TV, nomeadamente nos últimos dez anos, no tocante às produções da Rede Globo.

  9. Metal Fluoride Complexes of Na,K-ATPase

    Science.gov (United States)

    Cornelius, Flemming; Mahmmoud, Yasser A.; Toyoshima, Chikashi

    2011-01-01

    The Na,K-ATPase belongs to the P-type ATPase family of primary active cation pumps. Metal fluorides like magnesium-, beryllium-, and aluminum fluoride act as phosphate analogues and inhibit P-type ATPases by interacting with the phosphorylation site, stabilizing conformations that are analogous to specific phosphoenzyme intermediates. Cardiotonic steroids like ouabain used in the treatment of congestive heart failure and arrhythmias specifically inhibit the Na,K-ATPase, and the detailed structure of the highly conserved binding site has recently been described by the crystal structure of the shark Na,K-ATPase in a state analogous to E2·2K+·Pi with ouabain bound with apparently low affinity (1). In the present work inhibition, and subsequent reactivation by high Na+, after treatment of shark Na,K-ATPase with various metal fluorides are characterized. Half-maximal inhibition of Na,K-ATPase activity by metal fluorides is in the micromolar range. The binding of cardiotonic steroids to the metal fluoride-stabilized enzyme forms was investigated using the fluorescent ouabain derivative 9-anthroyl ouabain and compared with binding to phosphorylated enzyme. The fastest binding was to the Be-fluoride stabilized enzyme suggesting a preformed ouabain binding cavity, in accord with results for Ca-ATPase where Be-fluoride stabilizes the E2-P ground state with an open luminal ion access pathway, which in Na,K-ATPase could be a passage for ouabain. The Be-fluoride stabilized enzyme conformation closely resembles the E2-P ground state according to proteinase K cleavage. Ouabain, but not its aglycone ouabagenin, prevented reactivation of this metal fluoride form by high Na+ demonstrating the pivotal role of the sugar moiety in closing the extracellular cation pathway. PMID:21708939

  10. UTJECAJ STUPNJA USVOJENOSTI MARKETING KONCEPCIJE NA PROFITABILNOST PODUZEĆA

    OpenAIRE

    Nefat, Ariana; Belullo, Alen

    2000-01-01

    Autori su u radu istražili utjecaj stupnja usvojenosti marketing koncepcije na profitabilnost poduzeća izraženog putem ROA, jer tržišna orijentacija kao primjena marketing koncepcije univerzalno je prihvatljiva filozofija za istraživana poduzeća u Hrvatskoj. Nalaz njihova istraživanja potvrđuje hipotezu ovog rada da primjena marketing koncepcije pridonosi profitabilnosti poduzeća.

  11. A NOVA ERA NA IGREJA CATÓLICA

    Directory of Open Access Journals (Sweden)

    João Lupi

    2012-09-01

    Full Text Available O presente artigo foi apresentado na Mesa Redonda “Religiões e Religiosidades: entre a norma e o vivido (tensões e conciliações”, integrando o III Encontro do GT Nacional de História das Religiões e Religiosidades – ANPUH, na Universidade Federal de Santa Catarina (UFSC de 20 a 22 de Outubro de 2010.

  12. Naši suvelaagris mõnitatakse Eesti presidenti

    Index Scriptorium Estoniae

    2008-01-01

    Loode-Venemaale Tveri oblastisse suvelaagrisse kogunenud noorteliikumise Naši liikmed kutsuvad seal elavat siga Toomas Hendrik Ilveseks. Info pärineb Matt Siegeli pikemast artiklist "Nashi Summer Camp Tries a New Message", mis ilmus ajalehes The Moscow Times 21. juulil 2008. Ilmunud ka: Virumaa Teataja 22. juuli 2008, lk. 4, pealk.: Eesti presidenti mõnitati Naši suvelaagris; Eesti Elu 25. juuli 2008, lk. 3

  13. COMPETÊNCIA COMUNICATIVA ESCRITA NA ESCOLA

    Directory of Open Access Journals (Sweden)

    Nelly Carvalho

    2016-01-01

    Full Text Available Neste artigo, temos como objetivo refletir sobre a competência comunicativa escrita na escola. Paraisso, tecemos considerações acerca de concepções como competência linguística, competência comunicativapara chegarmos à concepção de competência comunicativa escrita, pois entendemos que essesfenômenos linguísticos se inter-relacionam, embora cada um preserve sua identidade. Para essa discussão,trazemos pontos de vista de pesquisadores, como Koch e Fávero, Marcuschi, Kleiman, dentreoutros. A propósito dessa questão, discutimos também concepções de alfabetização e letramento, nosentido de evidenciar o alcance de cada fenômeno no meio educacional. Por fim, discutimos algumassituações reais de uso da escrita para mostrar contextos de práticas sociais de letramento e suas relaçõescom o contexto escolar. Diante disso, fica claro que a escola deve considerar o saber prévio da criança,que está inserida em situações de escrita, o que implica em considerar aquilo que ela já sabe, em funçãode seu conhecimento de mundo, que é fundamental para sua aprendizagem. Palavras-chave: Competência comunicativa; Escrita; Letramento. ABSTRACT In this article, we aim to reflect on the communicative competence in writing at school. For this, weweave considerations about conceptions such as linguistic competence, communicative competencein order to reach a conception of communicative competence in writing; although these linguisticphenomena each preserve their own identities, we understand that they are interrelated. For thisdiscussion, we draw on views of researchers such as Koch and Favero, Marcuschi, Kleiman, amongothers. With respect to this issue, we also discuss conceptions of literacy and of “lettering”, in orderto reveal the reach of these phenomenona in the educational environment. Finally, we discuss somereal situations of the use of writing to show contexts of social practices of “lettering” and its relationshipwith

  14. Utjecaj derivata imidazola na koroziju bakra

    Directory of Open Access Journals (Sweden)

    Otmačić, H.

    2006-06-01

    Full Text Available Inhibiting efficiency of non-toxic imidazole derivatives (presented on Figure 1, as copper corrosion inhibitors in w = 3 % NaCl solution, was studied in the present work. Electrochemical investigations performed by potentiodynamic polarization measurements have shown that all studied compounds decrease the rate of copper corrosion while their inhibiting efficiency increases with molecular mass (Table 1. Except the molecular mass, the nature of the supstituent significantly influences the inhibiting property. Compounds containing alkyl supstituent show lower inhibiting efficiency than aryl containing imidazoles, but their efficiency is temperature independent while the efficiencies of aryl supstitued imidazoles slightly decrease with the increase of temperature (Fig. 3. Furthermore, alkyl imidazoles influence more on cathodic corrosion reaction, while aryl imidazoles have more influence on anodic corrosion reaction. Additional electrochemical (EQCM and EIS and spectroscopic investigations have shown that, even between the two most efficient corrosion inhibitors, 1-phenyl-4-methylimidazole and 1-(p-tolyl-4-methylimidazole, exist important differences in the mechanism of retardation of the corrosion process. The inhibitor that contains the tolyl substituent decreases the corrosion rate of copper due to the formation of thin layer of adsorbate, while in the case of 1-phenyl-4-methylimidazole, formation of thick layer can be followed with time (Fig. 4. From EIS (Electrochemical Impedance Spectroscopy studies, it was observed that these inhibitors significantly increase absolute impedance of copper which shows that they efficiently protect copper from corrosion. In the case of 1-phenyl-4-methylimidazole absolute impedance increases in time (Fig. 5 and 6 which means that the protective layer is slowly forming on the metal surface. Studies performed in the presence of 1-(p-tolyl-4-methylimidazole showed that already after short immersion time (Fig. 5

  15. Ecografia na patologia torácica

    Directory of Open Access Journals (Sweden)

    António Bugalho

    2010-07-01

    Full Text Available Resumo: Nos últimos anos a ecografia torácica tem vindo a ser reconhecida como um instrumento de extrema importância para os pneumologistas. Actualmente, os equipamentos são práticos, portáteis, de fácil utilização e fidedignos, o que os torna apropriados para utilização no diagnóstico e orientação de procedimentos terapêuticos.Na avaliação de derrame pleural e condução de toracentese são necessárias competências técnicas básicas em ultra-sonografia. Procedimentos mais complexos devem ser realizados perante treino específico e incluem a colocação de dreno torácico e identificação com eventual biopsia de lesões torácicas.Os autores procuram abordar, de um ponto de vista prático, a técnica e os recentes avanços alcançados neste campo. São apresentados alguns casos clínicos no sentido de ilustrar e guiar aqueles que desejam iniciar a realização de ecografia do tórax.Rev Port Pneumol 2010; XVI (4: 589-606 Abstract: In the past few years transthoracic ultrasound has been recognized as an important tool for chest physicians. At present, ultrasound devices are practical, portable, easy to use and reliable, which makes them suited for diagnostic investigations as well as for therapeutic procedures guidance.Basic ultrasound technical expertise is required to assess pleural effusions and perform ultrasound-guided thoracentesis. More complex procedures can be done with specific training and include assistance to chest drain insertion and identification with potential biopsy of thoracic lesions.The authors aim to review, in a practical approach, the technique and recent developments in this field. Clinical cases are presented in order to illustrate and guide the beginner in chest ultrasound.Rev Port Pneumol 2010; XVI (4: 589-606 Palavras-chave: Ecografia, ultra-sonografia, tórax, pleura, doenças pulmonares, derrame pleural, cancro do pulmão, Key-words: Ultrasound, sonography, chest, thorax, pleura, lung diseases

  16. Ecografia na patologia torácica

    Directory of Open Access Journals (Sweden)

    António Bugalho

    2010-07-01

    Full Text Available Resumo: Nos últimos anos a ecografia torácica tem vindo a ser reconhecida como um instrumento de extrema importância para os pneumologistas. Actualmente, os equipamentos são práticos, portáteis, de fácil utilização e fidedignos, o que os torna apropriados para utilização no diagnóstico e orientação de procedimentos terapêuticos.Na avaliação de derrame pleural e condução de toracentese são necessárias competências técnicas básicas em ultra-sonografia. Procedimentos mais complexos devem ser realizados perante treino específico e incluem a colocação de dreno torácico e identificação com eventual biopsia de lesões torácicas.Os autores procuram abordar, de um ponto de vista prático, a técnica e os recentes avanços alcançados neste campo. São apresentados alguns casos clínicos no sentido de ilustrar e guiar aqueles que desejam iniciar a realização de ecografia do tórax. Abstract: In the past few years transthoracic ultrasound has been recognized as an important tool for chest physicians. At present, ultrasound devices are practical, portable, easy to use and reliable, which makes them suited for diagnostic investigations as well as for therapeutic procedures guidance.Basic ultrasound technical expertise is required to assess pleural effusions and perform ultrasound-guided thoracentesis. More complex procedures can be done with specific training and include assistance to chest drain insertion and identification with potential biopsy of thoracic lesions.The authors aim to review, in a practical approach, the technique and recent developments in this field. Clinical cases are presented in order to illustrate and guide the beginner in chest ultrasound. Palavras-chave: Ecografia, ultra-sonografia, tórax, pleura, doenças pulmonares, derrame pleural, cancro do pulmão, Key-words: Ultrasound, sonography, chest, thorax, pleura, lung diseases, pleural effusion, lung cancer

  17. QUANDO FOGEM DE MIM NA ESCOLA…

    Directory of Open Access Journals (Sweden)

    Cristina Madureira

    2016-07-01

    Full Text Available Introdução: A Displasia Craniofrontonasal (CFND é uma doença rara ligada ao X, caracterizada por malformações cra- niofaciais graves, paradoxalmente associada a fenótipos mais exuberantes no sexo feminino. Caso Clínico: sexo feminino, pais jovens não consanguí- neos e sem antecedentes familiares relevantes, orientada para a consulta de Pediatria por malformações craniofaciais. Apre- sentava craniossinostose coronal com assimetria craniofacial e braquiturricefalia, fronte alta, larga e proeminente, hipertelorismo acentuado, ponta nasal bífida e baixa implantação dos pavilhões auriculares. Evidência de clinodactilia do 5º dedo e háluces lar- gos. O estudo genético identificou uma mutação frameshift no gene EFBN1 no cromossoma X, confirmando o diagnóstico de CFND. O estudo genético dos pais foi normal (mutação de novo. Foi orientada para a consulta de Genética Médica e de Cirurgia Plástica (rinoplastia e várias cirurgias de correção de hipertelorismo. O desenvolvimento psicomotor foi adequado e após ingresso no 1º ciclo verificaram-se dificuldades na adaptação escolar e relação com os pares, com aproveitamento satisfató- rio. A avaliação psicológica revelou baixa autoestima, ansiedade face à exposição social e dificuldade em lidar com a frustração. Atualmente apresenta dismorfias faciais com correção parcial, escoliose ligeira e miopia/astigmatismo, mantendo seguimento multidisciplinar. Comentários: Os autores pretendem alertar para a existência desta síndrome genética, assim como realçar a necessida- de de uma abordagem multidisciplinar destes casos. A par do tratamento cirúrgico, é fundamental o aconselhamento genético e o acompanhamento psicológico destas doentes, pela baixa autoestima e pelo risco de exclusão social associados a esta síndrome.

  18. O Telemarketing Ativo na Perspectiva do Consumidor

    Directory of Open Access Journals (Sweden)

    Tiago Savi Mondo

    2010-03-01

    Full Text Available A importância dos call-centers como forma de comunicação de marketing e a sua expansão no mercado conduziram à necessidade de se investigar o telemarketing à luz da percepção dos consumidores. Sendo assim, o objetivo do presente estudo é identificar a percepção dos consumidores finais de Florianópolis quanto aos serviços de comunicação do telemarketing ativo. Utilizou-se como referencial teórico abordagens sobre o marketing direto e características e propriedades do telemarketing ativo. A pesquisa caracteriza-se por ser de natureza exploratória, quantitativa do tipo survey. A amostra foi de 400 pessoas residentes na cidade de Florianópolis e o instrumento utilizado foi o questionário. Utilizaram-se procedimentos de estatística descritiva e análise de conteúdo para inferência e análise dos dados.Os resultados demonstram que os respondentes não gostam desse tipo de abordagem. Os motivos alegados por eles para não gostarem da abordagem foram: não concordância em receber contatos com objetivos de divulgação, venda ou pesquisa; falta de necessidade do produto oferecido ou de interesse por ele; sentimento de invasão com esse tipo de abordagem; indisponibilidade para atender a telefonemas com tais intenções; falta de tempo para ocuparem-se desses assuntos; falta de confiança e credibilidade para efetuar compras de produtos e serviços pelo telefone, além da percepção de perigo nesse tipo de transação. Sugestões gerenciais são apresentadas nas conclusões do artigo. DOI: 10.5585/remark.v8i2.2135

  19. Activation of the Na+,K+-ATPase in Narcine brasiliensis

    International Nuclear Information System (INIS)

    Blum, H.; Nioka, Shoko; Johnson, R.G. Jr.

    1990-01-01

    The in vivo activation and turnover rates of the sodium pump (Na + ,K + -ATPase) were investigated in the electrocytes of the electric organ of the elasmobranch Narcine brasiliensis. The Narcine electric organ appears to be an excellent model for the study of sodium pump activation in an excitable tissue. The sodium transmembrane gradient and high-energy phosphagens were concurrently measured by 23 Na and 31 P NMR spectroscopy. The resting electric organ, which depends primarily on anaerobic metabolism displays a high concentration of phosphocreatin (PCr). It has an intracellular sodium concentration ([Na + ] i ) of 20±10 milliequivalents/liter as estimated by NMR. Electrical stimulation of the nerves innervating the electric organ results in an increase in [Na + ] i in the electrolyte and rapid depletion of PCr. Ouabain causes an 85% decrease in utilization of high-energy phosphagens, indicating that rapid PCr turnover in this tissue is mainly due to Na + ,K + -ATPase activity. From these data the authors can determine that the rate of sodium pump turnover increases by >3 orders of magnitude within several hundred milliseconds. The authors conclude that cholinergic stimulation of the electric organ causes a rapid and extremely large increase in sodium pump turnover, which is regulated predominantly by factors other than [Na + ] i

  20. Band gap engineering for graphene by using Na+ ions

    International Nuclear Information System (INIS)

    Sung, S. J.; Lee, P. R.; Kim, J. G.; Ryu, M. T.; Park, H. M.; Chung, J. W.

    2014-01-01

    Despite the noble electronic properties of graphene, its industrial application has been hindered mainly by the absence of a stable means of producing a band gap at the Dirac point (DP). We report a new route to open a band gap (E g ) at DP in a controlled way by depositing positively charged Na + ions on single layer graphene formed on 6H-SiC(0001) surface. The doping of low energy Na + ions is found to deplete the π* band of graphene above the DP, and simultaneously shift the DP downward away from Fermi energy indicating the opening of E g . The band gap increases with increasing Na + coverage with a maximum E g ≥0.70 eV. Our core-level data, C 1s, Na 2p, and Si 2p, consistently suggest that Na + ions do not intercalate through graphene, but produce a significant charge asymmetry among the carbon atoms of graphene to cause the opening of a band gap. We thus provide a reliable way of producing and tuning the band gap of graphene by using Na + ions, which may play a vital role in utilizing graphene in future nano-electronic devices.

  1. Interactions of local anesthetics with voltage-gated Na+ channels.

    Science.gov (United States)

    Nau, C; Wang, G K

    2004-09-01

    Voltage-gated Na+ channels are dynamic transmembrane proteins responsible for the rising phase of the action potential in excitable membranes. Local anesthetics (LAs) and structurally related antiarrhythmic and anticonvulsant compounds target specific sites in voltage-gated Na+ channels to block Na+ currents, thus reducing excitability in neuronal, cardiac, or central nervous tissue. A high-affinity LA block is produced by binding to open and inactivated states of Na+ channels rather than to resting states and suggests a binding site that converts from a low- to a high-affinity conformation during gating. Recent findings using site-directed mutagenesis suggest that multiple S6 segments together form an LA binding site within the Na+ channel. While the selectivity filter may form the more extracellular-located part of this binding site, the role of the fast inactivation gate in LA binding has not yet been resolved. The receptor of the neurotoxin batrachotoxin (BTX) is adjacent to or even overlaps with the LA binding site. The close proximity of the LA and BTX binding sites to residues critical for inactivation, together with gating transitions through S6 segments, might explain the strong impact of LAs and BTX on inactivation of voltage-gated Na+ channels and might help elucidate the mechanisms underlying voltage- and frequency-dependent LA block.

  2. Deliquescence of NaCl–NaNO3, KNO3–NaNO3, and NaCl–KNO3 salt mixtures from 90 to 120°C

    Directory of Open Access Journals (Sweden)

    Wolery Thomas J

    2005-04-01

    Full Text Available We conducted reversed deliquescence experiments in saturated NaCl–NaNO3–H2O, KNO3–NaNO3–H2O, and NaCl–KNO3–H2O systems from 90 to 120°C as a function of relative humidity and solution composition. NaCl, NaNO3, and KNO3 represent members of dust salt assemblages that are likely to deliquesce and form concentrated brines on high-level radioactive waste package surfaces in a repository environment at Yucca Mountain, NV. Discrepancy between model prediction and experiment can be as high as 8% for relative humidity and 50% for dissolved ion concentration. The discrepancy is attributed primarily to the use of 25°C models for Cl–NO3 and K–NO3 ion interactions in the current Yucca Mountain Project high-temperature Pitzer model to describe the nonideal behavior of these highly concentrated solutions.

  3. Na2SO4-based solid electrolytes for SOx sensors

    DEFF Research Database (Denmark)

    Rao, N.; Schoonman, J.; Toft Sørensen, O.

    1992-01-01

    Na2SO4-based solid electrolytes with compositions Na2SO4 + x mol% Y2 (SO4)3 (x = 0, 3,5,6,9,12,15) and Na2SO4 + y mol% La2(SO4)3 (y = 0, 2, 4, 6, 8) were synthesized by solid state reaction. The crystal struCture, phaseS, and, electrical conductivity of these solid electrolytes were studied by XRD......, SEM, EDX, DTA, TGA and impedance spectroscopy. Upon doping with La2 (SO4)3 or Y2(SO4)3 the high-temperature fast-ion conducting phase NaSO4-I can be stabilized down to room temperature. Doping increases the ionic conductivity as well. Of these solid electrolytes the Na2SO4 + 5 mol% Y2(SO4)3 and Na2SO......$ + 4 mol% La2(SO4)3 solid solutions exhibit the highest ionic conductivity values (at 400-degrees-C, 1.76 X 10(-2) S cm-1 and 2.95 X 10(-2) S cm-1, respectively) and lowest activation enthalpies (0.38 eV and 0.37 eV, respectively). When x greater-than-or-equal-to 12 or y greater-than-or-equal-to 8...

  4. Reverse energy pooling in a K-Na mixture

    International Nuclear Information System (INIS)

    De Filippo, G.; Guldberg-Kjaer, S.; Milosevic, S.; Pedersen, J.O.; Allegrini, M.

    1998-01-01

    We report experimental rate coefficients for the reverse heteronuclear energy-pooling collisions K(5D)+Na(3S)→K(4P)+Na(3P) and K(7S)+Na(3S)→K(4P)+Na(3P) at thermal energies. Both reactions are exothermic and very high rates were observed showing that reverse exothermic energy-pooling is an order of magnitude more efficient than the corresponding forward endothermic energy-pooling reactions. This is in accordance with the general behavior of the exothermic and endothermic energy-pooling rate coefficients in alkali-metal atoms. In the experiment the potassium atoms were excited in two steps to either the 5D or 7S state via the 4P level using two broadband cw dye lasers. A double-modulation technique has been used to select the fluorescence contributions at the Na(3P J ) exit channels due only to the above reactions. The ground-state sodium and potassium atom densities were measured by the absorption of lines from a K-Na hollow-cathode lamp. The measured densities and fluorescence intensities have been used to obtain absolute reverse energy-pooling rate coefficients. The contribution to the rate coefficients from other processes are discussed. copyright 1998 The American Physical Society

  5. Custo de oportunidade: oculto na contabilidade, nebuloso na mente dos contadores

    Directory of Open Access Journals (Sweden)

    André Moura Cintra Goulart

    2002-12-01

    Full Text Available Este trabalho tem como objetivo desenvolver uma reflexão sobre o custo de oportunidade, buscandose constituir uma base adequada para a identificação de possíveis deficiências de conhecimento do referido conceito por parte dos profissionais da área contábil. Considerando-se sua relevância e grande potencial de aplicação nas atividades empresariais, como na avaliação de resultados, entende-se como fundamental a existência de compreensão sobre o custo de oportunidade e suas aplicações. Pesquisa exploratória realizada indica a validade da hipótese estabelecida, de que os profissionais da área contábil detêm conhecimento insatisfatório sobre o conceito objeto deste estudo. Assim, evidencia-se a necessidade de que mais atenção seja dada ao custo de oportunidade no processo de formação dos profissionais da contabilidade. Espera-se que estes profissionais, com segurança conceitual, estejam em condições de colaborar ativamente com o aproveitamento do custo de oportunidade em suas diversas aplicações, seja na contabilidade societária ou na gerencial, com benefícios para os usuários das informações contábeis.The objective of this article is to develop a reflection about opportunity cost, seeking to establish an adequate basis for the identification of possible knowledge deficiencies in the accounting professionals. Considering its relevance and great potential for application in business activities, such as performance assessment, it is observed that understanding the opportunity cost concept and its applications is fundamental.The exploratory research realized indicates the validity of the hypothesis that guides the development of the work, namely, that the accounting professionals possess unsatisfactory knowledge about the concept that is the object of this study. Thus, the need is highlighted to give more attention to opportunity cost in the educational process of the professionals. It is expected that these

  6. Evaluation of NaX and NaY packed beds for chromium uptake from multicomponent solution

    Directory of Open Access Journals (Sweden)

    Maria Angélica Simões Dornellas de Barros

    2014-04-01

    Full Text Available In this paper the removal of chromium from Cr/Ca/Mg/K and Cr/Ca/Mg/K/Na solutions was investigated in NaX and NaY packed beds. The breakthrough curves presented some overshooting phenomena where chromium ions displaced the previous exchanged cations. Length of unused bed, overall mass transfer coefficient, operational ratio and dimensionless variance were obtained. According to such mass transfer parameters it was concluded that the chromium uptake is influenced by the competition and interaction of the entering ions. Such influences were verified through some differences in the dynamic selectivity obtained for each system. NaY seemed to have a higher affinity towards Cr3+ and its sites were more efficiently used in the ion exchange process.

  7. Imunidade na gestação normal e na paciente com lúpus eritematoso sistêmico (LES)

    OpenAIRE

    Pereira,Alessandra Cardoso; Jesús,Nilson Ramires de; Lage,Lais Verderame; Levy,Roger Abramino

    2005-01-01

    A gravidez é uma condição fisiológica na qual ocorrem várias mudanças imunoendócrinas com a finalidade de facilitar a imunossupressão e a tolerância aos antígenos paternos e fetais. Na gravidez humana normal existe uma relativa supressão de citocinas tipo Th1 na resposta dos linfócitos, levando a uma prevalência na resposta do tipo Th2. No LES, onde prevalece a resposta imune do tipo Th2, a gravidez pode estar relacionada com a ativação da doença. Este artigo é uma revisão dessas alterações r...

  8. Modification of NaK (Na and K) dissolution device at the L.E.C.I

    International Nuclear Information System (INIS)

    Mansard, Bernard; Ducas, Serge; Riviere, Michel

    1969-12-01

    As three NaK dissolution devices had been operated since 1965 and as irradiation assemblies with a greater capacity (2 to 3 times) are now to be used, the modification of these dissolution devices is addressed. This requires a better control of the dissolution reaction (the NaK + alcohol reaction is highly exothermic and results in an effervescence which requires a greater volume). The objectives are therefore to delay the dissolution, to trigger it, to stop it, to control it at will, and to release heat. The new device is then described with its vessel, its cap, its ball valve, and its two tight sleeves. The operation principle is described, as well as the NaK draining process, and the NaK dissolution. Safety, time saving and raw matter saving issues are finally outlined

  9. Conductivity, Thermal Measurements, and Phase Diagram of the Na2S2O7-NaHSO4 System

    DEFF Research Database (Denmark)

    Hatem, G.; Gaune-Escard, M.; Rasmussen, Søren Birk

    1999-01-01

    The conductivity of the Na2S2O7-NaHSO4 binary system has been measured for 15 different compositions in the full composition range, and in the temperature range 400-700 K.Phase transition temperatures were obtained, and the phase diagram constructed. It is of thesimple eutectic type, where......, as found earlier for theK2S2O7-KHSO4 system. For each composition measured of the Na2S2O7-NaHSO4 system inthe molten state, the conductivity has been expressed by equations of the form = A(X) +B(X)(T - Tm) + C(X)(T-Tm)^2, where Tm is the intermediate temperature of the measuredtemperature range....

  10. The rise of [Na(+)] (i) during ischemia and reperfusion in the rat heart-underlying mechanisms.

    Science.gov (United States)

    Williams, Iwan A; Xiao, Xiao-hui; Ju, Yue-kun; Allen, David G

    2007-09-01

    Intracellular Na(+) concentration ([Na(+)](i)) rises in the heart during ischemia, and on reperfusion, there is a transient rise followed by a return toward control. These changes in [Na(+)](i) contribute to ischemic and reperfusion damage through their effects on Ca(2+) overload. Part of the rise of [Na(+)](i) during ischemia may be caused by increased activity of the cardiac Na(+)/H(+) exchanger (NHE1), activated by the ischemic rise in [H(+)](i). In support of this view, NHE1 inhibitors reduce the [Na(+)](i) rise during ischemia. Another possibility is that the rise of [Na(+)](i) during ischemia is caused by Na(+) influx through channels. We have reexamined these issues by use of two different NHE1 inhibitors, amiloride, and zoniporide, in addition to tetrodotoxin (TTX), which blocks voltage-sensitive Na(+) channels. All three drugs produced cardioprotection after ischemia, but amiloride (100 microM) and TTX (300 nM) prevented the rise in [Na(+)](i) during ischemia, whereas zoniporide (100 nM) did not. Both amiloride and zoniporide prevented the rise of [Na(+)](i) on reperfusion, whereas TTX was without effect. In an attempt to explain these differences, we measured the ability of the three drugs to block Na(+) currents. At the concentrations used, TTX reduced the transient Na(+) current (I (Na)) by 11 +/- 2% while amiloride and zoniporide were without effect. In contrast, TTX largely eliminated the persistent Na(+) current (I (Na,P)) and amiloride was equally effective, whereas zoniporide had a substantially smaller effect reducing I (Na,P) to 41 +/- 8%. These results suggest that part of the effect of NHE1 inhibitors on the [Na(+)](i) during ischemia is by blockade of I (Na,P). The fact that a low concentration of TTX eliminated the rise of [Na(+)](i) during ischemia suggests that I (Na,P) is a major source of Na(+) influx in this model of ischemia.

  11. Thermoluminescence and F centers of manganese doped NaCl and NaCl-CKl crystals exposed to gamma radiation

    Energy Technology Data Exchange (ETDEWEB)

    Somera, L.; Cruz Z, E.; Roman L, J. [UNAM, Instituto de Ciencias Nucleares, Circuito Exterior, Ciudad Universitaria, 04510 Mexico D. F. (Mexico); Hernandez A, J. M.; Murrieta S, H., E-mail: ecruz@nucleares.unam.mx [UNAM, Instituto de Fisica, Circuito Exterior, Ciudad Universitaria, 04510 Mexico D. F. (Mexico)

    2015-10-15

    Alkali halides crystals doped with rare earths or transition metals have been widely studied due to the luminescence properties. In particular, NaCl and KCl single crystals present thermally stimulated luminescence (Tl) after gamma irradiation. The NaCl and the NaCl KCl mixed crystal doped with manganese (MnCl{sub 2}) impurity were grown by using the Czochralski method. The emission characteristic of Mn{sup 2+} was observed at 543 nm. The crystals were exposed between 0.02 and 10 kGy gamma dose from {sup 60}Co irradiator. Optical absorption at room temperature shows the peaked band at 452 nm corresponding to the manganese impurity. The F bands, was ascribed to the electron trapped in the anion vacancy in the lattice, were obtained at 452 nm and 455 nm belonging to NaCl:Mn and NaCl KCl:Mn, respectively. The F band increases as the doses increase and it was bleaching by the UV light at 470 nm. The glow curves of the samples show the first glow peak between 92-103 degrees C, while the second main peak was observed at 183 degrees C for the undoped NaCl and at 148 and 165 degrees C for the NaCl:Mn and NaCl-KCl:Mn, respectively. The main peak was slowly bleaching when the irradiated sample was illuminated with F (470 nm) light. Optical bleaching confirms that the F center has an important participation in the thermoluminescent response. The glow curves structure from the thermal bleaching suggests the participation of different kind of traps. Also, the kinetics parameters such as activation energy (E), frequency factor (s) and the kinetic order (b) were investigated. (Author)

  12. Thermoluminescence and F centers of manganese doped NaCl and NaCl-CKl crystals exposed to gamma radiation

    International Nuclear Information System (INIS)

    Somera, L.; Cruz Z, E.; Roman L, J.; Hernandez A, J. M.; Murrieta S, H.

    2015-10-01

    Alkali halides crystals doped with rare earths or transition metals have been widely studied due to the luminescence properties. In particular, NaCl and KCl single crystals present thermally stimulated luminescence (Tl) after gamma irradiation. The NaCl and the NaCl KCl mixed crystal doped with manganese (MnCl 2 ) impurity were grown by using the Czochralski method. The emission characteristic of Mn 2+ was observed at 543 nm. The crystals were exposed between 0.02 and 10 kGy gamma dose from 60 Co irradiator. Optical absorption at room temperature shows the peaked band at 452 nm corresponding to the manganese impurity. The F bands, was ascribed to the electron trapped in the anion vacancy in the lattice, were obtained at 452 nm and 455 nm belonging to NaCl:Mn and NaCl KCl:Mn, respectively. The F band increases as the doses increase and it was bleaching by the UV light at 470 nm. The glow curves of the samples show the first glow peak between 92-103 degrees C, while the second main peak was observed at 183 degrees C for the undoped NaCl and at 148 and 165 degrees C for the NaCl:Mn and NaCl-KCl:Mn, respectively. The main peak was slowly bleaching when the irradiated sample was illuminated with F (470 nm) light. Optical bleaching confirms that the F center has an important participation in the thermoluminescent response. The glow curves structure from the thermal bleaching suggests the participation of different kind of traps. Also, the kinetics parameters such as activation energy (E), frequency factor (s) and the kinetic order (b) were investigated. (Author)

  13. Mobilidade Social na Idade Média: um breve estudo sobre os ministeriales na Alemanha

    Directory of Open Access Journals (Sweden)

    José Henrique Rollo

    2013-10-01

    Full Text Available http://dx.doi.org/10.5007/2178-4582.2013v47n2p289 A imagem veiculada pelos manuais de história da sociedade europeia medieval como uma organização piramidal rígida usualmente negligencia alguns grupos sociais que experimentaram alguma forma de mobilidade social vertical. Um desses grupos foram os ministeriales ou dienstmänner, homens não-livres empregados pela Igreja e pela nobreza como burocratas e soldados. Embora tenham existido em diversos países, eles foram particularmente importantes na Alemanha dos séculos IX a XIII. Este artigo apresenta algumas de suas principais características como grupo social, analisa brevemente os padrões de mobilidade e expõe algumas das interpretações historiográficas a seu respeito.

  14. Aspectos da tomografia computadorizada craniana na neurocisticercose na infância

    Directory of Open Access Journals (Sweden)

    Marilisa M. Guerreiro

    1989-06-01

    Full Text Available Os autores relatam aspectos tomográficos da neurocisticercose na infância a propósito da análise de 27 exames em 18 pacientes, que foram distribuídos em três grupos segundo o quadru clínico e os achados tomográficos. O grupo 1 foi caracterizado basicamente por epilepsias e calcificações. O grupo 2 caracterizou-se por hipertensão intracraniana e diversos aspectos tomográficos: edema, cistos e nódulos em três pacientes; hidrocefalia e calcificações em dois pacientes e normal em um paciente. O grupo 3 consistiu clinicamente de epilepsia e cefaléia, com vários padrões tomográficos. Os resultados são discutidos à luz da literatura disponível.

  15. Cafeína e desempenho anaeróbio

    Directory of Open Access Journals (Sweden)

    Fabrizio Caputo

    2012-08-01

    Full Text Available DOI: http://dx.doi.org/10.5007/1980-0037.2012v14n5p602 O efeito ergogênico da cafeína em exercícios anaeróbios permanece controverso, parecendo ser dependente da duração do exercício, protocolo utilizado e do estado de treinamento dos sujeitos estudados. Assim, esta revisão surge na tentativa de analisar as pesquisas que investigaram o efeito da cafeína no desempenho de exercícios predominan­temente anaeróbios e principalmente, discutir a respeito dos diferentes métodos utilizados, objetivando verificar de que forma isto pode explicar os resultados controversos, além de apresentar os possíveis mecanismos de ação da cafeína. Em simples esforços anaeróbios com duração inferior a 30 segundos, a cafeína parece exercer influência no desempenho apenas em atletas, no entanto, mais estudos precisam ser feitos nesta população. Já em exercícios um pouco mais extensos (de 60 até 180 segundos, a cafeína parece melhorar o desempenho independentemente do estado de treinamento. O mecanismo de ação ainda não está claro, entretanto, existem evidências que a ação da cafeína é multifatorial, visto que esta substância altera características centrais e periféricas. Dentre as principais características, a cafeína atua como receptor antagônico de adenosina, aumentando a excitabilidade do sistema nervoso central e alterando a percepção de esforço e de dor, além disso, diminui a sensibilidade do retículo sarcoplasmático na liberação do cálcio. Novas pesquisas que investiguem o papel da cafeína em exercícios anaeróbios devem ser realizadas, utilizando amostras de indivíduos adaptados ao treinamento anaeróbio, bem como protocolos semelhantes ao de esportes cíclicos a fim de esclarecer os resultados contraditórios.

  16. Influence of hexavanadates on Na+/K+- ATPase activity

    Directory of Open Access Journals (Sweden)

    Zdravković Aleksandra

    2016-01-01

    Full Text Available Introduction: There is a great interest in use of polioximetalates in clinical medicine, primary as antibacterial, antiviral and antitumoral agents. Considering the key role of Na+/ K+- ATPase in normal functioning of most animal cells, as well as pivotal roles in cancer cell migration, the aim of this paper was to examine the influence of new synthesized hexavandates [V6-CH3][Na]2, [V6-NO2][TBA]2, [V6-C3][H]2, [V6-C5d][TBA]2 on Na+/K+- ATPase activity. Material and methods: The enzymatic activity of porcine cerebral cortex Na+/K+- ATPase was followed in both the absence and presence of increasing concentration of [V6-CH3] [Na]2, [V6-NO2][TBA]2, [V6-C3][H]2, [V6-C5d][TBA]2 (within the range 10-8 - 10-3 mol/L. The released Pi, liberated from the enzymatic hydrolysis of ATP, was determined by spectrophotometric method, using Perkin Elmer Lambda 35 UV-VIS spectrophotometer. Results: Investigated compounds inhibit the activity of Na+/K+ ATPase in dose-dependent manner within the investigated range. Obtained results indicate that all investigated compounds inhibit the Na+/K+ ATPase activity, but with different inhibiting power. [V6-NO2] [TBA]2 (IC50 = 1,87 × 10-5 mol/L was the most potent inhibitor of Na+/K+ ATPase, while [V6-C5d][TBA]2 showed the least potent inhibiting power (IC50 = 1,31 × 10-4 mol/L . The results are consistent with previously published concentration-dependent inhibitory effect of polyoxometalates (including polioxovandates on ATPase activity from different model syistems. Conclusion: Based on the results, we can conclude that the examined compounds inhibit Na+/K+- ATPase activity in a dose-dependent manner. Inhibiting power of tested hexavanadates are different, and weaker than inhibiting power of decavanadates (tested earlier on Na+/K+- ATPase activity, which is probably due to differences in charge, size and shape of these polioxometalates. Considering the role of this enzymes in the functioning of healthy cells and the

  17. Comparison of the Coordination of B12F122-, B12Cl122-, and B12H122- to Na+ in the Solid State: Crystal Structures and Thermal Behavior of Na2(B12F12), Na2(H2O)4(B12F12), Na2(B12Cl12), and Na2(H2O)6(B12Cl12).

    Science.gov (United States)

    Bukovsky, Eric V; Peryshkov, Dmitry V; Wu, Hui; Zhou, Wei; Tang, Wan Si; Jones, W Matthew; Stavila, Vitalie; Udovic, Terrence J; Strauss, Steven H

    2017-04-17

    The synthesis of high-purity Na 2 B 12 F 12 and the crystal structures of Na 2 (B 12 F 12 ) (5 K neutron powder diffraction (NPD)), Na 2 (H 2 O) 4 (B 12 F 12 ) (120 K single-crystal X-ray diffraction (SC-XRD)), Na 2 (B 12 Cl 12 ) (5 and 295 K NPD), and Na 2 (H 2 O) 6 (B 12 Cl 12 ) (100 K SC-XRD) are reported. The compound Na 2 (H 2 O) 4 (B 12 F 12 ) contains {[(Na(μ-H 2 O) 2 Na(μ-H 2 O) 2 )] 2+ } ∞ infinite chains; the compound Na 2 (H 2 O) 6 (B 12 Cl 12 ) contains discrete [(H 2 O) 2 Na(μ-H 2 O) 2 Na(H 2 O) 2 ] 2+ cations with OH···O hydrogen bonds linking the terminal H 2 O ligands. The structures of the two hydrates and the previously published structure of Na 2 (H 2 O) 4 (B 12 H 12 ) are analyzed with respect to the relative coordinating ability of B 12 F 12 2- , B 12 H 12 2- , and B 12 Cl 12 2- toward Na + ions in the solid state (i.e., the relative ability of these anions to satisfy the valence of Na + ). All three hydrated structures have distorted octahedral NaX 2 (H 2 O) 4 coordination spheres (X = F, H, Cl). The sums of the four Na-O bond valence contributions are 71, 75, and 89% of the total bond valences for the X = F, H, and Cl hydrated compounds, respectively, demonstrating that the relative coordinating ability by this criterion is B 12 Cl 12 2- ≪ B 12 H 12 2- X 12 ) compounds provide additional evidence that B 12 Cl 12 2- is more weakly coordinating than B 12 F 12 2- to Na + in the solid state. Taken together, the results suggest that the anhydrous, halogenated closo-borane compounds Na 2 (B 12 F 12 ) and Na 2 (B 12 Cl 12 ), in appropriately modified forms, may be viable component materials for fast-ion-conducting solid electrolytes in future energy-storage devices.

  18. A escolha amorosa e interação conjugal na heterossexualidade e na homossexualidade

    Directory of Open Access Journals (Sweden)

    Féres-Carneiro Terezinha

    1997-01-01

    Full Text Available Este estudo tem como objetivo investigar o processo de escolha amorosa em homens e mulheres hetero e homossexuais das camadas médias da população, de diferentes faixas etárias, em diversas situações amorosas - namoro, casamento (coabitação estável, separação e recasamento (segunda ou subsequente coabitação estável; as características das relações dos conflitos conjugais por eles estabelecidas; e o papel atribuído à terapia de casal na resolução dos conflitos conjugais. Foram estudados dois grupos: 240 heterossexuais (53 solteiros, 64 casados, 63 separados e 60 recasados e 116 homossexuais (49 solteiros, 36 casados, 19 separados e 12 recasados. Na avaliação da escolha amorosa foram utilizados 26 atributos dispostos em escalas de avaliação de 5 pontos, tal como proposto por Buss (1989, e entrevistas semi-estruturadas a partir de Féres-Carneiro (1987, contendo tópicos referentes a dimensões relevantes da interação conjugal. Os resultados mostraram algumas diferenças entre homens e mulheres de ambos os grupos e algumas semelhanças no processo de escolha amorosa dos sujeitos hetero e dos sujeitos homossexuais. Tais resultados são relevantes para a prática clínica da terapia de casal, possibilitando uma melhor compreensão das especificidades da relação amorosa em diferentes tipos de conjugalidade.

  19. Wpływ zlodzenia na rzece Wkrze na jej zasoby energetyczne

    Directory of Open Access Journals (Sweden)

    Sławomir Bajkowski

    2014-12-01

    Full Text Available Zasoby energii wodnej są zróżnicowane obszarowo oraz ulegają zmianom okresowym. Zależą one od naturalnych lub regulowanych przepływów i stanów oraz czynników powodujących ich okresowe zmiany, zarastania i zlodzenia koryta. Podstawowym problemem związanym z pracą elektrowni wodnych w okresie zimowym jest tworzenie się form lodowych ograniczających dopływ wody do wlotów ujęć. Początek okresu zlodzenia zależy od czynników meteorologicznych, temperatur powietrza, opadów śniegu, związanych z eksploatacją obiektów wodnych, temperatury zrzutów wody i stosowania pływających przegród w miejscach, gdzie woda ma najmniejszą prędkość. W artykule przedstawiono analizę podstawowych parametrów wykorzystywanych w ocenie zasobów energetycznych rzek. Do określania form i okresów występowania zjawisk lodowych wykorzystano historyczne dane hydrologiczne, a współczynniki redukcji zimowej ustalono, analizując stany i przepływy. Współczynnik redukcji zimowej obliczono na podstawie krzywych przepustowości koryta rzeki odnosząc przepływy dla okresu zimowego do uzyskanych z krzywej podstawowej. Analizy obejmują przekrój Cieksyn na rzece Wkrze, w którym wystąpiło zlodzenie powodujące zmiany głównych krzywych hydroenergetycznych.

  20. The effect of Na+ and K+ on the thermal denaturation of Na+ and + K+-dependent ATPase.

    Science.gov (United States)

    Fischer, T H

    1983-01-01

    To increase our understanding of the physical nature of the Na+ and K+ forms of the Na+ + K+-dependent ATPase, thermal-denaturation studies were conducted in different types of ionic media. Thermal-denaturation measurements were performed by measuring the regeneration of ATPase activity after slow pulse exposure to elevated temperatures. Two types of experiments were performed. First, the dependence of the thermal-denaturation rate on Na+ and K+ concentrations was examined. It was found that both cations stabilized the pump protein. Also, K+ was a more effective stabilizer of the native state than was Na+. Secondly, a set of thermodynamic parameters was obtained by measuring the temperature-dependence of the thermal-denaturation rate under three ionic conditions: 60 mM-K+, 150 mM-Na+ and no Na+ or K+. It was found that ion-mediated stabilization of the pump protein was accompanied by substantial increases in activation enthalpy and entropy, the net effect being a less-pronounced increase in activation free energy. PMID:6309139